LLukas22/scidocs huggingface dataset:
Long-term outcome with dasatinib after imatinib failure in chronic-phase chronic myeloid leukemia: follow-up of a phase 3 study.

We present long-term follow-up of a dasatinib phase 3 study of patients with imatinib-resistant/-intolerant chronic myeloid leukemia (CML). In the CA180-034 study, 670 patients with imatinib-resistant/-intolerant CML in chronic phase (CML-CP) received dasatinib 100 mg once daily, 50 mg twice daily, 140 mg once daily, or 70 mg twice daily. At 6 years, 188 (28%) of 670 patients remained on study treatment. Estimated 6-year protocol-defined progression-free survival (PFS) rates were 49%, 51%, 40%, and 47%, respectively, and estimated 6-year overall survival (OS) rates were 71%, 74%, 77%, and 70%, respectively (intent-to-treat population, including protocol-defined progression or death after discontinuation). Estimated 6-year rates of survival without transformation on study treatment were 76%, 80%, 83%, and 74%, respectively. Major molecular response was achieved in 43% (100 mg once daily) and 40% (all other arms) of patients by 6 years. Molecular and cytogenetic responses at 3 and 6 months were highly predictive of PFS and OS. Notably, estimated 6-year PFS rates based on ≤1%, >1% to 10%, and >10% BCR-ABL transcripts at 3 months were 68%, 58%, and 26%, respectively. Most adverse events occurred by 2 years. Imatinib-resistant/-intolerant patients with CML-CP can experience long-term benefit with dasatinib therapy, particularly if achieving BCR-ABL ≤10% at 3 months. This study was registered at ClinicalTrials.gov: NCT00123474.
Foley catheter versus vaginal prostaglandin E2 gel for induction of labour at term (PROBAAT trial): an open-label, randomised controlled trial

BACKGROUND
Induction of labour is a common obstetric procedure. Both mechanical (eg, Foley catheters) and pharmacological methods (eg, prostaglandins) are used for induction of labour in women with an unfavourable cervix. We aimed to compare the effectiveness and safety of induction of labour with a Foley catheter with induction with vaginal prostaglandin E2 gel.


METHODS
We did an open-label, randomised controlled trial in 12 hospitals in the Netherlands between Feb 10, 2009, and May 17, 2010. We enrolled women with a term singleton pregnancy in cephalic presentation, intact membranes, an unfavourable cervix, an indication for induction of labour, and no prior caesarean section. Participants were randomly allocated by an online randomisation system to induction of labour with a 30 mL Foley catheter or vaginal prostaglandin E2 gel (1:1 ratio). Because of the nature of the intervention this study was not blinded. The primary outcome was caesarean section rate. Secondary outcomes were maternal and neonatal morbidity and time from intervention to birth. All analyses were done on an intention-to-treat basis. We also did a meta-analysis that included our trial. The trial was registered with the Dutch trial registry, number NTR 1646.


FINDINGS
824 women were allocated to induction of labour with a Foley catheter (n=412) or vaginal prostaglandin E2 gel (n=412). Caesarean section rates were much the same between the two groups (23%vs 20%, risk ratio [RR] 1·13, 95% CI 0·87-1·47). A meta-analysis including our trial data confirmed that a Foley catheter did not reduce caesarean section rates. We recorded two serious maternal adverse events, both in the prostaglandin group: one uterine perforation and one uterine rupture.


INTERPRETATION
In women with an unfavourable cervix at term, induction of labour with a Foley catheter is similar to induction of labour with prostaglandin E2 gel, with fewer maternal and neonatal side-effects.


FUNDING
None.
Attack of the creationist reverberators! Or: the end of the world (as we know it)

This special issue of Popular Communication examines the impact of the global financial crisis and recession on differnt aspects of global and regional media and the cultural industries, changing practices of media production, as well as media consumption, and the interplay of economic challenges and technological change.
Teacher Learning in a Context of Educational Change: Informal Learning Versus Systematically Supported Learning

After certification, teachers do not often receive systematic support in their learning and hence mainly depend on informal learning opportunities at work. The present study addresses the question of if and how supervision makes a difference to teacher learning. In a longitudinal mixed-method study, the learning of one teacher is documented in a year in which she had no systematic support but had to adjust herself to an educational innovation. The authors also studied this teacher in a consecutive year in which she did receive individual supervision. During supervision, the teacher became aware of beliefs and patterns that had previously inhibited her from change. This awareness precipitated significant changes in her beliefs and classroom behavior as well as the way she learned. The findings suggest that professional learning will take place only if a teacher is supported in learning how to deal effectively with personal factors involved in the learning process.
Five-year outcomes following a randomized trial of femorofemoral and femoropopliteal bypass grafting with heparin-bonded or standard polytetrafluoroethylene grafts.

BACKGROUND
Cohort studies suggest superior long-term patency of luminal heparin-bonded polytetrafluoroethylene (Hb-PTFE) bypass grafts compared with standard PTFE grafts. The aim of this study was to compare the outcomes of Hb-PTFE grafts with those of standard PTFE grafts 5 years after a randomized trial.


METHODS
Patients with intermittent claudication or critical limb ischaemia requiring femorofemoral or femoropopliteal bypass grafting were randomized in a clinical trial of Hb-PTFE versus standard PTFE in 11 Scandinavian centres between 2005 and 2009. Patients were followed up for 5 years with clinical assessment and surveillance Duplex ultrasound imaging. The primary endpoint of this study was primary patency. Secondary endpoints included major amputation and mortality.


RESULTS
Overall, 569 patients were enrolled in the randomized trial. Some 552 had follow-up data available for analysis of the primary outcome. Use of Hb-PTFE significantly improved patency by 37 per cent at 2 years, but 5 years after randomization there was no difference in primary patency (adjusted hazard ratio (HR) 0·95, 95 per cent c.i. 0·71 to 1·28; P = 0·748). In patients with critical limb ischaemia the use of Hb-PTFE reduced the 5-year risk of loss of primary patency by 37 per cent (HR 0·63, 0·40 to 0·99; P = 0·049).


CONCLUSION
In this study there was no difference in primary graft patency between Hb-PTFE and standard PTFE grafts. Patients receiving Hb-PTFE grafts for critical limb ischaemia were more likely to have a patent graft at 5 years than those with standard PTFE grafts.
BizPro: Extracting and categorizing business intelligence factors from textual news articles

Company movements and market changes often are headlines of the news, providing managers with important business intelligence (BI). While existing corporate analyses are often based on numerical financial figures, relatively little work has been done to reveal from textual news articles factors that represent BI. In this research, we developed BizPro, an intelligent system for extracting and categorizing BI factors from news articles. BizPro consists of novel text mining procedures and BI factor modeling and categorization. Expert guidance and human knowledge (with high inter-rater reliability) were used to inform system development and profiling of BI factors. We conducted a case study of using the system to profile BI factors of four major IT companies based on 6859 sentences extracted from 231 news articles published in major news sources. The results show that the chosen techniques used in BizPro – Naïve Bayes (NB) and Logistic Regression (LR) – significantly outperformed a benchmark technique. NB was found to outperform LR in terms of precision, recall, F-measure, and area under ROC curve. This research contributes to developing a new system for profiling company BI factors from news articles, to providing new empirical findings to enhance understanding in BI factor extraction and categorization, and to addressing an important yet under-explored concern of BI analysis. © 2014 Elsevier Ltd. All rights reserved.
A Delphi study to identify indicators of poorly managed pain for pediatric postoperative and procedural pain.

BACKGROUND
Adverse health care events are injuries occurring as a result of patient care. Significant acute pain is often caused by medical and surgical procedures in children, and it has been argued that undermanaged pain should be considered to be an adverse event. Indicators are often used to identify other potential adverse events. There are currently no validated indicators for undertreated pediatric pain.


OBJECTIVES
To develop a preliminary list of indicators of undermanaged pain in hospitalized pediatric patients.


METHODS
The Delphi technique was used to survey experts in pediatric pain management and quality improvement. The first round used an electronic questionnaire to ask: "In your opinion, what indicators would signify that acute pain in a child has not been adequately controlled?" Responses were grouped together in semantically similar themes, providing a list of possible adverse event indicators. Using this list, an electronic questionnaire was developed for round 2 asking respondents to indicate the importance of each potential indicator.


RESULTS
All but one indicator achieved a level of consensus ≥70%. Separate indicators emerged for postoperative and procedural pain. An additional distinction was made between indicators that could be identified by chart review and those requiring observation of practice and assessment from the child or parent.


DISCUSSION
The adverse care indicators developed in the present study require further refinement. There is a need to test their clinical usability and to determine whether these indicators actually identify undermanaged pain in clinical practice. The present study is an important first step in identifying undermanaged pain in hospital and treating it as an adverse event.


CONCLUSION
The adverse care indicators developed in the present study are the first step in conceptualizing mismanaged pain as an adverse event.
The association between periodontal disease and periosteal lesions in the St. Mary Graces cemetery, London, England A.D. 1350-1538.

Numerous studies have demonstrated significant associations between periodontal disease and many other diseases in living populations, and some studies have shown that individuals with periodontal disease are at elevated risks of mortality. Recent analysis of a medieval skeletal sample from London has also shown that periodontal disease was associated with increased risks of mortality in the past. This study examines whether periodontal disease is associated with periosteal lesions in a skeletal sample from the urban St. Mary Graces cemetery (n = 265) from medieval London. The results reveal a significant association between periodontal disease and periosteal lesions in the St. Mary Graces sample (i.e., individuals with periodontal disease were also likely to have periosteal lesions), and the association between the two is independent of age. The association between the two pathological conditions might reflect underlying reduced immune competence and thus heightened susceptibility to pathogens that cause periodontal disease or periosteal lesions, exposure to an environmental factor, or underlying heightened inflammatory responses.
Long short term memory neural network for keyboard gesture decoding

Gesture typing is an efficient input method for phones and tablets using continuous traces created by a pointed object (e.g., finger or stylus). Translating such continuous gestures into textual input is a challenging task as gesture inputs exhibit many features found in speech and handwriting such as high variability, co-articulation and elision. In this work, we address these challenges with a hybrid approach, combining a variant of recurrent networks, namely Long Short Term Memories [1] with conventional Finite State Transducer decoding [2]. Results using our approach show considerable improvement relative to a baseline shape-matching-based system, amounting to 4% and 22% absolute improvement respectively for small and large lexicon decoding on real datasets and 2% on a synthetic large scale dataset.
Colchicine to Reduce Atrial Fibrillation in the Postoperative Period
of Myocardial Revascularization

BACKGROUND
The high prevalence of atrial fibrillation (AF) in the postoperative period of myocardial revascularization surgery increases morbidity and mortality.


OBJECTIVE
To assess the efficacy of colchicine to prevent AF in the postoperative period of myocardial revascularization surgery, the impact of AF on hospital length of stay and death, and to identify its risk factors.


METHODS
Between May 2012 and November 2013, 140 patients submitted to myocardial revascularization surgery were randomized, 69 to the control group and 71 to the colchicine group. Colchicine was used at the dose of 1 mg orally, twice daily, preoperatively, and of 0.5 mg, twice daily, until hospital discharge. A single dose of 1 mg was administered to those admitted 12 hours or less before surgery.


RESULTS
The primary endpoint was AF rate in the postoperative period of myocardial revascularization surgery. Colchicine group patients showed no reduction in AF incidence as compared to control group patients (7.04% versus 13.04%, respectively; p = 0.271). There was no statistically significant difference between the groups regarding death from any cause rate (5.6% versus 10.1%; p = 0,363) and hospital length of stay (14.5 ± 11.5 versus 13.3 ± 9.4 days; p = 0.490). However, colchicine group patients had a higher infection rate (26.8% versus 8.7%; p = 0.007).


CONCLUSION
The use of colchicine to prevent AF after myocardial revascularization surgery was not effective in the present study. Brazilian Registry of Clinical Trials number RBR-556dhr.
A prospective randomized study of clinical and economic consequences of using G-CSF following autologous peripheral blood progenitor cell (PBPC) transplantation in children

Summary:This prospective and randomized study was conducted to evaluate clinical and economic consequences of using granulocyte colony-stimulating factor (G-CSF) following autologous peripheral blood progenitor cell (PBPC) transplantation in children. Between January 1999 and December 2003, 117 patients underwent autologous PBPCT: 51 patients received G-CSF following PBPCT, while 66 patients did not receive G-CSF. Median time to absolute neutrophil count >0.5 × 109/l was 10 days in the treatment group and 11 days in the control group (P<0.009). The median time to platelets >20 × 109/l was 12 days in both groups (P=NS). The median time to platelets >50 × 109/l was 15 days in the G-CSF group and 14 days in the control group (P<0.005). In patients who received <5 × 106/kg CD34+ cells, the median time to platelets >20 × 109/l and >50 × 109/l was similar with or without G-CSF (12 and 15 days, respectively). Platelet transfusion requirements were lower in the control group (2 vs 3 U in G-CSF group). There was a trend towards higher total costs with G-CSF: 8146.82 euros and 7873.34 euros with and without G-CSF, respectively (P=0.1). Our data suggest that there is no indication of the standard application of G-CSF in children following PBPC transplantation. The only possible indication is the group of patients with a lower yield of CD34+ cells.
From the Internet of Computers to the Internet of Things

This paper1 discusses the vision, the challenges, possible usage scenarios and technological building blocks of the “Internet of Things”. In particular, we consider RFID and other important technological developments such as IP stacks and web servers for smart everyday objects. The paper concludes with a discussion of social and governance issues that are likely to arise as the vision of the Internet of Things becomes a reality.
Cytokines in the systemic inflammatory response syndrome: a review

INTRODUCTION
Patients subject to major surgery, suffering sepsis, major trauma, or following cardiopulmonary bypass exhibit a systemic inflammatory response. This inflammatory response involves a complex array of inflammatory polypeptide molecules known as cytokines. It is well accepted that the loss of local control of the release of these cytokines leads to systemic inflammation and potentially deleterious consequences including the Systemic Inflammatory Response Syndrome, Multi-Organ Dysfunction Syndrome, shock and death.


METHODS
The Medline database was searched for literature on mechanisms involved in the development of SIRS and potential targets for modifying the inflammatory response. We focus on the novel therapy of cytokine adsorption as a promising removal technology.


RESULTS
Accumulating data from human studies and experimental animal models suggests that both pro- and anti- inflammatory cytokines are released following a variety of initiating stimuli including endotoxin release, complement activation, ischaemia reperfusion injury and others.


DISCUSSION
Pro-and anti-inflammatory cytokines interact in a complex and unpredictable manner to influence the immune system and eventually cause multiple end organ effects. Cytokine adsorption therapy provides a potential solution to improving outcomes following Systemic Inflammatory Response Syndrome.
Prices & availability of common medicines at six sites in India using a standard methodology.

BACKGROUND & OBJECTIVE
The price and availability of medicines are key components in determining access to effective treatment. Data on prices and availability of common medicines in public and private sector in different States of India are scarce. Hence, surveys were undertaken in different States of India to evaluate these metrics.


METHODS
During October 2004 to January 2005, six surveys were undertaken simultaneously in five States of India to assess medicine prices and availability of essential medicines (n = 21-28) using the World Health Organization and Health Action International methodology. Surveys were conducted at Chennai, Haryana, Karnataka, West Bengal, and at two sites in Maharashtra. For each medicine, data were collected for the Innovator Brand (IB), Most Sold Generic (MSG), and Lowest Priced Generic (LPG) at randomly selected public and private facilities in each site surveyed. Prices were compared to an international reference benchmark (expressed as median price ratio - MPR).


RESULTS
The procurement price of medicines in the public sector was 0.27 to 0.48 times the international reference price. However, these medicines were inadequately available and the median availability in the public sector ranged from 0 to 30 per cent. The median prices of medicines in the private sector were less than twice the IRP, although a few innovator brands were more expensive. No difference was observed between the prices of the most sold generic (MSG) and the lowest priced generic (LPG) available at the facilities. Interestingly, price variation was observed among different generic equivalents of ciprofloxacin in each region. The price of LPG diazepam in the private sector was thirty three times its procurement price in the public sector.


INTERPRETATION & CONCLUSION
The survey revealed low procurement prices and poor availability in the public sector. Thus, the majority of the population purchased medicines from private pharmacies, where generics were usually available although prices of certain medicines were high. Various policy measures could increase the availability and accessibility of medicines for the population.
Surgical treatment of Peyronie's disease: choosing the best approach to improve patient satisfaction.

AIM
To discuss important points on medical history, preoperative evaluation, real expectations, and selection of the appropriate surgical procedure to improve patient satisfaction after surgical procedures for Peyronie's disease.


METHODS
Recent advances in approaches to Peyronie's disease are discussed based on the literature and personal experiences. Issues concerning surgical indication, patient selection, surgical techniques, and grafting are discussed. Lengthening procedures on the convex side of the penile curvature by means of grafting offer the best possible gain from a reconstruction standpoint. Penile rectification and rigidity are required to achieve a completely functional penis. Most patients experience associated erectile dysfunction (ED), and penile straightening alone may not be enough to restore complete function. Twenty-five patients were submitted to total penile reconstruction on length and girth with concomitant penile prosthesis implant. The maximum length restoration was possible and limited by the length of the dissected neurovascular bundle. The mean age was 55.4 years (32-69 years) and the mean angle of curvature 74.2+/-22.4 degree (0-100 degree). Pericardial grafting was used to cover the defect. The mean follow-up time was 11.2 +/- 5.9 months (3-22 months).


RESULTS
Mean functional penile length gain was 3.40+/-0.73 cm (2-5 cm). Penile prosthesis maintained the penis straight. No infections occurred. Sexual intercourse was restored in all patients and all reported recovered self-esteem.


CONCLUSION
Improving patient satisfaction with the surgical treatment includes proper preoperative evaluation on stable disease, penile shortening, vascular and erectile status, patient decision and selection as well as extensive discussion on surgical technique for restoring functional penis (length and rigidity). Length and girth restoration is very important for self-esteem and patient satisfaction.
ADAPTATION MODEL IN A CONTROLLED CLINICAL TRIAL INVOLVING FAMILY CAREGIVERS OF CHRONIC PATIENTS Leidy

Objective: to elaborate the conceptual and theoretical-empirical structure, based on the application of Roy’s Adaptation model, to guide the development of a controlled clinical trial aimed at assessing the effectiveness of a nursing intervention program to promote the adaptation of family caregivers with caregiver role strain. Method: theoretical study. The conceptual structure was developed in three phases: development of a comprehensive understanding of the conceptual model, literature review and construction of the conceptual and theoretical-empirical structure itself. Results: the application process demonstrated its consistency in the design of an intervention program for family caregivers of chronic patients, to be tested in a controlled clinical trial. The indicators of adaptation were the reduced score on the caregiver tension scale and the increased perception of wellbeing and quality of life. Conclusion: Roy’s model serves as an important guide for nursing research intended to test nursing interventions that favor the wellbeing of family caregivers. DESCRIPTORS: Caregivers. Nursing. Nursing theory. Chronic disease. MODELO DE ADAPTAÇÃO EM UM ENSAIO CLÍNICO CONTROLADO COM CUIDADORES FAMILIARES DE PESSOAS COM DOENÇAS CRÔNICAS