LLukas22/scidocs huggingface dataset:
Extended abdominoperineal resection with gluteus maximus flap reconstruction of the pelvic floor for rectal cancer.

BACKGROUND
Intraoperative tumour perforation, positive tumour margins, wound complications and local recurrence are frequent difficulties with conventional abdominoperineal resection (APR) for rectal cancer. An alternative technique is the extended posterior perineal approach with gluteus maximus flap reconstruction of the pelvic floor. The aim of this study was to report the technique and early experience of extended APR in a select cohort of patients.


METHODS
The principles of operation are that the mesorectum is not dissected off the levator muscles, the perineal dissection is done in the prone position and the levator muscles are resected en bloc with the anus and lower rectum. The perineal defect is reconstructed with a gluteus maximus flap. Between 2001 and 2005, 28 patients with low rectal cancer were treated accordingly at the Karolinska Hospital.


RESULTS
Two patients had ypT0 tumours, 20 ypT3 and six ypT4 tumours. Bowel perforation occurred in one, the circumferential resection margin (CRM) was positive in two, and four patients had local perineal wound complications. Two patients developed local recurrence after a median follow-up of 16 months.


CONCLUSION
The extended posterior perineal approach with gluteus maximus flap reconstruction in APR has a low risk of bowel perforation, CRM involvement and local perineal wound complications. The rate of local recurrence may be lower than with conventional APR.
Use of Pulsed Ultraviolet Light to Reduce the Allergenic Potency of Soybean Extracts

Pulsed ultraviolet light (PUV), a non-thermal food processing technology, is reported to be able to inactivate enzymes and reduce allergen levels from peanut extracts. The objective of this study was to determine if PUV would reduce the allergen levels and allergenic potency of soy extracts. Soy extracts were treated with PUV at various times (2, 4 and 6 min), centrifuged, and analyzed by SDS-PAGE and an indirect ELISA for IgE binding or allergenic potency. Results showed that PUV treatment led to an increase in sample temperature/weight loss but a decrease in the levels of soy allergens (i.e., glycinin and β-conglycinin) as shown in SDS-PAGE. Allergens were reduced probably through aggregation which increased with treatment time. IgE binding was reduced as well in the following order: 20%, 44% and 50% reductions in absorbance values at 2, 4, 6 min, respectively (the latter two were not significantly different (p< 0.05%) from each other). It was concluded that PUV was capable of reducing the allergenic potency of soy extracts, and that the optimal PUV treatment time was 4 min. Clinical data is still needed before PUV can find an application in the development of less allergenic soybean beverages and products.
"No thanks, it keeps me awake": the genetics of coffee-attributed sleep disturbance.

STUDY OBJECTIVES
Previous genetic investigations of sleep disturbance have shown various measures of sleep quality and sleep pattern to be heritable. But none of these studies have investigated the genetic predisposition to sleep disturbance attributed to caffeine. In this study, the heritability of coffee-attributed sleep disturbance and its relationship with other sleep measures were estimated, and chromosomal regions influencing this trait were identified.


DESIGN
A classical twin design was used to estimate the heritability of coffee-attributed sleep disturbance and its genetic covariance with other measures of sleep disturbance (e.g., due to anxiety, depression) and sleep quality (e.g., variability in sleep quality). To locate quantitative trait loci influencing coffee-attributed sleep disturbance, a genome-wide linkage screen of 1395 microsatellite markers was performed.


PARTICIPANTS
The study included 3808 Australian adult twin pairs (n = 1799 monozygous pairs; n = 2009 dizygous pairs). A subsample of 1989 individuals from 1175 families was used for the linkage analysis.


MEASUREMENTS AND RESULTS
The heritability of coffee-attributed sleep disturbance (measured by self report) was approximately 0.40, with three fourths of this genetic variance explained by genes unrelated to the general sleep disturbance factor. One region of significant linkage to coffee-attributed sleep disturbance was identified on chromosome 2q (LOD score of 2.9).


CONCLUSIONS
Although no candidate genes known to be related to caffeine metabolism or sleep disorder were identified in the significant linkage region, 2 candidates were found under a smaller peak on chromosome 17q.
Protocol for SAMS (Support and Advice for Medication Study): A randomised controlled trial of an intervention to support patients with type 2 diabetes with adherence to medication

BACKGROUND
Although some interventions have been shown to improve adherence to medication for diabetes, results are not consistent. We have developed a theory-based intervention which we will evaluate in a well characterised population to test efficacy and guide future intervention development and trial design.


METHODS AND DESIGN
The SAMS (Supported Adherence to Medication Study) trial is a primary care based multi-centre randomised controlled trial among 200 patients with type 2 diabetes and an HbA1c of 7.5% or above. It is designed to evaluate the efficacy of a two-component motivational intervention based on the Theory of Planned Behaviour and volitional action planning to support medication adherence compared with standard care. The intervention is delivered by practice nurses. Nurses were trained using a workshop approach with role play and supervised using assessment of tape-recorded consultations. The trial has a two parallel groups design with an unbalanced three-to-two individual randomisation eight weeks after recruitment with twelve week follow-up. The primary outcome is medication adherence measured using an electronic medication monitor over 12 weeks and expressed as the difference between intervention and control in mean percentage of days on which the correct number of medication doses is taken. Subgroup analyses will explore impact of number of medications taken, age, HbA1c, and self-reported adherence at baseline on outcomes. The study also measures the effect of dispensing medication to trial participants packaged in the electronic medication-monitoring device compared with conventional medication packaging. This will be achieved through one-to-one randomisation at recruitment to these conditions with assessment of the difference between groups in self-report of medication adherence and change in mean HbA1c from baseline to eight weeks. Anonymised demographic data are collected on non-respondents. Central randomisation is carried out independently of trial co-ordination and practices using minimisation to adjust for selected confounders.


DISCUSSION
The SAMS intervention and trial design address weaknesses of previous research by recruitment from a well-characterised population, definition of a feasible theory based intervention to support medication taking and careful measurement to estimate and interpret efficacy. The results will inform practice and the design of a cost-effectiveness trial [ISRCTN30522359].
The effect of a 4-week comprehensive rehabilitation program on postural control and lower extremity function in individuals with chronic ankle instability.

STUDY DESIGN
Prospective, randomized controlled trial.


OBJECTIVE
To examine the effects of a 4-week rehabilitation program for chronic ankle instability (CAI) on postural control and lower extremity function.


BACKGROUND
CAI is associated with residual symptoms, performance deficits, and reinjury. Managing CAI is challenging and more evidence is needed to guide effective treatment.


METHODS AND MEASURES
Subjects with unilateral CAI were randomly assigned to the rehabilitation (CAI-rehab, n=16) or control (CAI-control, n=13) group. Subjects without CAI were assigned to a healthy group (n=19). Baseline testing included the (1) center of pressure velocity (COPV), (2) star excursion balance test (SEBT), and (3) Foot and Ankle Disability index (FADI) and FADI-Sports Subscale (FADI-Sport). The CAI-rehab group completed 4 weeks of rehabilitation that addressed range of motion, strength, neuromuscular control, and functional tasks. After 4 weeks, all subjects were retested. Nonparametric analyses for group differences and between-group comparisons were performed.


RESULTS
Subjects with CAI demonstrated deficits in postural control and SEBT reach tasks of the involved limb compared to the uninvolved limb and reported functional deficits of the involved limb compared to healthy subjects. Following rehabilitation, the CAI-rehab group had greater SEBT reach improvements on the involved limb than the other groups and greater improvements in FADi and FADI-Sport scores.


CONCLUSIONS
These results demonstrate postural control and functional limitations exist in individuals with CAl. In addition, rehabilitation appears to improve these functional limitations. Finally, there is evidence to suggest the SEBT may be a good functional measure to monitor change after rehabilitation for CAI.
SHAPE-INVARIANCE AND MANY-BODY PHYSICS

Recent developments in the study of shape-invariant Hamiltonians are briefly summarized. Relations between certain exactly solvable problems in many-body physics and shape-invariance are explored. Connection between Gaudin algebras and supersymmetric quantum mechanics is pointed out.
Self-* Storage: Brick-based Storage with Automated Administration (CMU-CS-03-178)

This white paper describes a new project exploring the design and implementation of “self-* storage systems:” selforganizing, self-configuring, self-tuning, self-healing, self-managing systems of storage bricks. Borrowing organizational ideas from corporate structure and automation technologies from AI and control systems, we hope to dramatically reduce the administrative burden currently faced by data center administrators. Further, compositions of lower cost components can be utilized, with available resources collectively used to achieve high levels of reliability, availability, and performance. We thank the members and companies of the PDL Consortium (including EMC, Hewlett-Packard, Hitachi, IBM, Intel, Microsoft, Network Appliance, Oracle, Panasas, Seagate, Sun, and Veritas) for their interest, insights, feedback, and support. Aspects of the self-* storage project are funded by DARPA, AFOSR, NSF, and the PDL Consortium. Report Documentation Page Form Approved OMB No. 0704-0188 Public reporting burden for the collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden, to Washington Headquarters Services, Directorate for Information Operations and Reports, 1215 Jefferson Davis Highway, Suite 1204, Arlington VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to a penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. 1. REPORT DATE AUG 2003 2. REPORT TYPE 3. DATES COVERED 00-00-2003 to 00-00-2003 4. TITLE AND SUBTITLE Self-*Storage: Brick-based storage with automated administration 5a. CONTRACT NUMBER
Evaluation of Antibacterial Activity of Flower Extracts of Cassia auriculata L.

Since plants are used as therapeutic agents, the present study was conducted to evaluate the phytochemical profile and antibacterial activities of flower extracts of Cassia auriculata. Studies on the antibacterial activity of ethanol, methanol and aqueous extracts of dry flower and ethanol, methanol and acetone extracts of fresh flower of Cassia auriculata was conducted using agar disc diffusion method. The microorganisms used include Staphylococcus aureus, Enterococcus faecalis, Bacillus subtilis, Salmonella typhi, Salmonella paratyphi A, Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa, Klebsiella pneumoniae, Vibrio cholerae and Shigella dysentrae. The maximum activity was observed against all organisms except Pseudomonas aeruginosa and Klebsiella pneumoniae. The minimum inhibitory concentration ranged between 12.5mg/mL and 75mg/mL depending on microorganism and various extract. Presence of phytochemicals such as terpenoids, tannins, flavonoids, saponin, cardiac glycosides and steroids were observed. Cassia auriculata was observed to have antibacterial activity and can be used for medicinal purposes.
Text Mining for Causal Relations

Given a semantic relation, the automatic extraction of linguistic patterns that express that relation is a rather difficult problem. This paper presents a semi-automatic method of discovering generally applicable lexico-syntactic patterns that refer to the causal relation. The patterns are found automatically, but their validation is done semi-automatically.
From early virtual garment simulation to interactive fashion design

Virtual garment design and simulation involves a combination of a large range of techniques, involving mechanical simulation, collision detection, and user interface techniques for creating garments. Here, we perform an extensive review of the evolution of these techniques made in the last decade to bring virtual garments to the reach of computer applications not only aimed at graphics, but also at CAD techniques for the garment industry. As a result of the advances in the developments of virtual garment simulation technologies, we then detail a framework which fits the needs of the garment industry of virtual garment design and prototyping, concentrating on interactive design, simulation and visualization features. The framework integrates innovative tools aimed towards efficiency and quality in the process of garment design and prototyping, taking advantage of state-of-the-art algorithms from the field of mechanical simulation, animation and rendering.
Canine substitution of a missing maxillary lateral incisor in an orthodontic retreatment case : long term follow up Case report

Introduction: This case report describes the orthodontic re-treatment of a case with a severely compromised maxillary lateral incisor requiring removal and canine substitution. The treatment included creative asymmetric treatment mechanics and a careful management of anchorage. Case Presentation: Pre-treatment, post treatment and 5 years follow-up records are shown. The treatment outcomes proved to be stable at the follow-up with acceptable aesthetic and functional results. Conclusion: Through careful management of anchorage it was possible to successfully use asymmetric treatment mechanics to achieve a good functional occlusion. Submitted: October 16, 2016; Revised: January 29, 2017; Published: April 14, 2017 Lupini D, Lempert S, Cozzani M. Canine substitution of a missing maxillary lateral incisor in an orthodontic re-treatment case: long term follow up. South Eur J Orthod Dentofac Res. 2017;(4)1:14-19. South Eur J Orthod Dentofac Res Lupini D. et al. Missing maxillary lateral incisor 15 The clinical presentation of a patient missing one or both maxillary lateral incisors can vary and through careful planning and ingenuity the orthodontist can develop a plan that takes into account the patient’s unique findings. With multiple treatment options available it is best to have the patient’s pre-treatment expectations aligned with the doctor’s treatment goals to provide the best opportunity for patient satisfaction. The following case report shows the creative management of a severely compromised maxillary lateral incisor that had been subject to failed prior treatment attempts. Literature reports many cases of canine substitution of missing lateral incisor, but very few reports are associated with severe root resorption conditions. 8,9 Ultimately, this tooth required removal and canine substitution. Through asymmetric treatment mechanics it was possible to achieve a pleasing, functional smile and a satisfied patient.
Improved walking ability and reduced therapeutic stress with an electromechanical gait device.

OBJECTIVE
To evaluate the effectiveness of repetitive locomotor training using a newly developed electromechanical gait device compared with treadmill training/gait training with respect to patient's ambulatory motor outcome, necessary personnel resources, and discomfort experienced by therapists and patients.


METHODS
Randomized, controlled, cross-over trial. Sixteen non-ambulatory patients after stroke, severe brain or spinal cord injury sequentially received 2 kinds of gait training. Study intervention A: 20 treatments of locomotor training with an electromechanical gait device; control intervention B: 20 treatments of locomotor training with treadmill or task-oriented gait training. The primary variable was walking ability (Functional Ambulation Category). Secondary variables included gait velocity, Motricity-Index, Rivermead-Mobility-Index, number of therapists needed, and discomfort and effort of patients and therapists during training.


RESULTS
Gait ability and the other motor outcome related parameters improved for all patients, but without significant difference between intervention types. However, during intervention A, significantly fewer therapists were needed, and they reported less discomfort and a lower level of effort during training sessions.


CONCLUSION
Locomotor training with or without an electromechanical gait trainer leads to improved gait ability; however, using the electromechanical gait trainer requires less therapeutic assistance, and therapist discomfort is reduced.
Who benefits from additional drug counseling among prescription opioid-dependent patients receiving buprenorphine-naloxone and standard medical management?

BACKGROUND
In the multi-site Prescription Opioid Addiction Treatment Study (POATS), conducted within the National Drug Abuse Clinical Trials Network, participants randomly assigned to receive individual drug counseling in addition to buprenorphine-naloxone and medical management did not have superior opioid use outcomes. However, research with other substance-dependent populations shows that subgroups of participants may benefit from a treatment although the entire population does not.


METHOD
We conducted a secondary analysis of POATS data to determine whether a subgroup of participants benefited from drug counseling in addition to buprenorphine-naloxone and medical management, either due to greater problem severity or more exposure to counseling as a result of greater treatment adherence. Problem severity was measured by a history of heroin use, higher Addiction Severity Index drug composite score, and chronic pain. Adequate treatment adherence was defined a priori as attending at least 60% of all offered sessions.


RESULTS
Patients who had ever used heroin and received drug counseling were more likely to be successful (i.e., abstinent or nearly abstinent from opioids) than heroin users who received medical management alone, but only if they were adherent to treatment and thus received adequate exposure to counseling (OR=3.7, 95% CI=1.1-11.8, p=0.03). The association between severity and outcome did not vary by treatment condition for chronic pain or ASI drug severity score.


CONCLUSIONS
These findings emphasize the importance of treatment adherence, and suggest that patients with prescription opioid dependence are a heterogeneous group, with different optimal treatment strategies for different subgroups.
The Rapid Growth of Cybercrimes Affecting Information Systems in the Global : Is this a Myth or Reality in Tanzania ?

The main objective of this study was to determine w hether the rapid growth of cybercrimes affecting in formation systems in the global: is a myth or reality in Tanz ia. The study was undertaken using a mixed resear ch methods. The research findings reveal that 12.8 % of users are victims of cybercrimes due to visiting unhealthy websites in cyberspace, more than 90.89% of users have been denied access to torrents /p2p applications (with malicious codes); and more than 63.29% of e-mails received by users are spam. It has been noted that Internet users has risen to 5.63 million users in 2012 out of 46.9 million of population in Tanzania; and is increasing at the ra t of 416.98% per year thus expectation of 7.34 mil lion users of Internet by December 2015. The increase in the number of Intern e users has direct implication to the increase in cybercrimes affecting information systems. The Government of Tanzania has declared that “about 320 people were apprehended b etween July and December 2011of which over 1bn/, Euro 8,897 and U SD 551,777 reported to have been stolen through cyb er”. The study concluded that there is a need for a holistic appro ach in addressing cybercrimes in a developing count ry like Tanzania. Key words-. Cybercrime; information systems; cyberspace; cyber security.
Ecological Monitoring and Its Development in China

Ecological monitoring is a novel concept to traditional environmental monitoring, which is a technical guarantee and supporting system for the construction of environmental ecology. In this article, the basic concept and principle, the objectives, tasks as well as characteristics of ecological monitoring, establishment of conceptual model of ecosystem and classification of ecological monitoring indicators are introduced, some suggestions and prospect for ecological monitoring are also proposed.
Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients.

BACKGROUND
Sodium-glucose cotransporter 2 (SGLT2) inhibitors lower glycemia by enhancing urinary glucose excretion. The physiologic response to pharmacologically induced acute or chronic glycosuria has not been investigated in human diabetes.


METHODS
We evaluated 66 patients with type 2 diabetes (62 ± 7 years, BMI = 31.6 ± 4.6 kg/m(2), HbA1c = 55 ± 8 mmol/mol, mean ± SD) at baseline, after a single dose, and following 4-week treatment with empagliflozin (25 mg). At each time point, patients received a mixed meal coupled with dual-tracer glucose administration and indirect calorimetry.


RESULTS
Both single-dose and chronic empagliflozin treatment caused glycosuria during fasting (median, 7.8 [interquartile range {IQR}, 4.4] g/3 hours and 9.2 [IQR, 5.2] g/3 hours) and after meal ingestion (median, 29.0 [IQR, 12.5] g/5 hours and 28.2 [IQR, 15.4] g/5 hours). After 3 hours of fasting, endogenous glucose production (EGP) was increased 25%, while glycemia was 0.9 ± 0.7 mmol/l lower (P < 0.0001 vs. baseline). After meal ingestion, glucose and insulin AUC decreased, whereas the glucagon response increased (all P < 0.001). While oral glucose appearance was unchanged, EGP was increased (median, 40 [IQR, 14] g and 37 [IQR, 11] g vs. 34 [IQR, 11] g, both P < 0.01). Tissue glucose disposal was reduced (median, 75 [IQR, 16] g and 70 [IQR, 21] g vs. 93 [IQR, 18] g, P < 0.0001), due to a decrease in both glucose oxidation and nonoxidative glucose disposal, with a concomitant rise in lipid oxidation after chronic administration (all P < 0.01). β Cell glucose sensitivity increased (median, 55 [IQR, 35] pmol • min(-1) • m(-2) • mM(-1) and 55 [IQR, 39] pmol • min(-1) • m(-2) • mM(-1) vs. 44 [IQR, 32] pmol • min(-1) • m(-2) • mM(-1), P < 0.0001), and insulin sensitivity was improved. Resting energy expenditure rates and those after meal ingestion were unchanged.


CONCLUSIONS
In patients with type 2 diabetes, empagliflozin-induced glycosuria improved β cell function and insulin sensitivity, despite the fall in insulin secretion and tissue glucose disposal and the rise in EGP after one dose, thereby lowering fasting and postprandial glycemia. Chronic dosing shifted substrate utilization from carbohydrate to lipid. Trial registration. ClinicalTrials.Gov NCT01248364 (EudraCT no. 2010-018708-99). Funding. This study was funded by Boehringer Ingelheim.