LLukas22/scidocs huggingface dataset:
H89, an inhibitor of PKA and MSK, inhibits cyclic-AMP response element binding protein-mediated MAPK phosphatase-1 induction by lipopolysaccharide

Lipopolysaccharide (LPS) stimulates the production of inflammatory cytokines and the amplification of immune responses via MAPK pathways. MAPK phosphatases (MKPs) feedback-regulate the activities of MAPKs to prevent excessive immunological functions. H89 has been used as an inhibitor of the protein kinase A (PKA) and mitogen- and stress-activated protein kinase (MSK) pathways. In view of the potential roles of PKA and MSK for MKP-1 induction and the ability of H89 to inhibit these kinases, this study examined the effect of H89 on MKP-1 induction by LPS and the role of cyclic-AMP response element binding protein (CREB) in the MKP-1 induction. H89 treatment inhibited increases in MKP-1 protein and mRNA levels, and gene transcription by LPS in Raw264.7 cells. Immunoblot, gel-shift, and chromatin-immunoprecipitation assays showed the activation of CREB by LPS, and the ability of H89 to inhibit it, suggesting that H89’s inhibition of CREB may affect MKP-1 induction. In addition, H89 prevented the ability of LPS to induce other MKP genes (Dusp-2, 4, 8, and 16). Experiments using MAPK inhibitors showed that MAPKs are involved in CREB phosphorylation and MKP-1 induction, suggesting that CREB-mediated MKP-1 induction serves in part as a feedback-inhibitory loop of MAPKs. Our results demonstrate that H89 inhibits the activation of CREB and the CREB-mediated MKP-1 induction by LPS, which may result from its inhibition of PKA and MSK.
Real-time elderly activity monitoring system based on a tri-axial accelerometer.

PURPOSE
The purpose of this study is to develop an automatic human movement classification system for the elderly using single waist-mounted tri-axial accelerometer.


METHODS
Real-time movement classification algorithm was developed using a hierarchical binary tree, which can classify activities of daily living into four general states: (1) resting state such as sitting, lying, and standing; (2) locomotion state such as walking and running; (3) emergency state such as fall and (4) transition state such as sit to stand, stand to sit, stand to lie, lie to stand, sit to lie, and lie to sit. To evaluate the proposed algorithm, experiments were performed on five healthy young subjects with several activities, such as falls, walking, running, etc.


RESULTS
The results of experiment showed that successful detection rate of the system for all activities were about 96%. To evaluate long-term monitoring, 3 h experiment in home environment was performed on one healthy subject and 98% of the movement was successfully classified.


CONCLUSIONS
The results of experiment showed a possible use of this system which can monitor and classify the activities of daily living. For further improvement of the system, it is necessary to include more detailed classification algorithm to distinguish several daily activities.
Unsaturated soils: From constitutive modelling to numerical algorithms

This paper presents an overview of constitutive modelling of unsaturated soils and the numerical algorithms for solving the associated boundary value problems. It first discusses alternative stress and strain variables that can be used in constitutive models for unsaturated soils. The paper then discusses the key issues in unsaturated soil modelling and how these issues can be incorporated into an existing model for saturated soils. These key issues include (1) volumetric behaviour associated with saturation or suction changes; (2) strength behaviour associated with saturation and suction changes, and (3) hydraulic behaviour associated with saturation or suction changes. The paper also shows how hysteresis in soil–water characteristics can be incorporated into the elasto-plastic framework, leading to coupled hydro-mechanical models. Finally, the paper demonstrates the derivation of the incremental stress–strain relations for unsaturated soils and discusses briefly the new challenges in implementing these relations into the finite
Precise determination of the critical threshold and exponents in a three-dimensional continuum percolation model

We present a large-scale computer simulation of the prototypical three-dimensional continuum percolation model consisting of a distribution of overlapping (spatially uncorrelated) spheres. By using simulations of up to 10 5 particles and studying the finite-size scaling of various effective percolation thresholds, we obtain a value of pc = 0.2895±0.0005. This value is significantly smaller than the values obtained for simulations that have been carried out using smaller systems. Employing this value of pc and systems of size L = 160 (relative to a sphere of unit radius), we also obtain estimates of the critical exponents ν, β, andγ for the continuum system and show that the values are different than those obtained using previous values of pc.
Narco-Terrorism : The Merger of the War on Drugs and the War on Terror

The aim of this article is to analyse the phenomena of narco-terrorism and the practical measures utilised to counter this threat. By adopting the model of the crime-terror continuum developed by Tamara Makarenko, the article will outline the similarities and dissimilarities of narcotics trafficking and terrorism in order to provide a more nuanced perspective on the concept of narco-terrorism. By doing so, the article will evaluate the kind of approach taken in combating the threat of narco-terrorism.
Ellipsoidal Toolbox (ET)

Ellipsoidal Toolbox is the first free MATLAB package that implements the operations of ellipsoidal calculus: geometric (Minkowski) sums and differences of ellipsoids, intersections of ellipsoids, and ellipsoids with hyperplanes and polyhedra. The toolbox uses ellipsoidal methods to compute forward and backward reach sets of continuous- and discrete-time piecewise affine systems. Forward and backward reach sets can be also computed for continuous-time piece-wise linear systems with disturbances
Psychological capital : internal and external validity of the Psychological Capital Questionnaire (PCQ-24) on a South African sample : original research

Occupational stress and burnout are serious problems in modern organisations. The cost of high stress and burnout levels to employers include higher staff turnover, lower morale, excessive sick leave and reduced productivity and efficiency (e.g. Cordes & Dougherty, 1993; Lee & Ashforth, 1996; Schaufeli & Enzmann, 1998; Wright & Bonett, 1997). Studies from the emerging field of positive organisational behaviour (POB) (Luthans, 2002) have shown that the construct of psychological capital (PsyCap) (i.e. a higher order constellation of positive psychological components that consists of hope, optimism, self-efficacy and resilience), may contribute to decreased stress (e.g. Avey, Luthans & Jensen, 2009) and increased work engagement (Avey, Wernsing & Luthans, 2008). Within the framework of Hobfoll’s (2002) psychological resources theory, Luthans, Youssef and Avolio (2007, p. 10) define PsyCap as ‘an individual’s positive psychological state of development, characterised by: (1) having confidence (self-efficacy) to take on and put in the necessary effort to succeed at challenging tasks; (2) making a positive attribution (optimism) about succeeding now and in the future; (3) persevering towards goals, and when necessary, redirecting paths to goals (hope) in order to succeed; and (4) when beset by problems and adversity, sustaining and bouncing back and even beyond (resiliency) to attain success’. In essence, PsyCap represents an individual’s, ‘positive appraisal of circumstances and probability for success based on motivated effort and perseverance’ (Luthans, Avolio, Avey & Norman, 2007, p. 550). PsyCap has been shown to impact a range of workplace outcomes like job performance (Luthans, Avolio, Avey & Norman, 2007; Luthans, Avolio, Walumbwa & Li, 2005), stress (e.g. Avey et al., 2009) and well-being (Culberson, Fullagar & Mills, 2010). Page 1 of 12
Effects of dance on movement control in Parkinson's disease: a comparison of Argentine tango and American ballroom.

OBJECTIVE
The basal ganglia may be selectively activated during rhythmic, metered movement such as tango dancing, which may improve motor control in individuals with Parkinson's disease. Other partner dances may be more suitable and preferable for those with Parkinson's disease. The purpose of this study was to compare the effects of tango, waltz/foxtrot and no intervention on functional motor control in individuals with Parkinson's disease.


DESIGN
This study employed a randomized, between- notsubject, prospective, repeated measures design.


SUBJECTS/PATIENTS
Fifty-eight people with mild-moderate Parkinson's disease participated.


METHODS
Participants were randomly assigned to tango, waltz/foxtrot or no intervention (control) groups. Those in the dance groups attended 1-h classes twice a week, completing 20 lessons in 13 weeks. Balance, functional mobility, forward and backward walking were evaluated before and after the intervention.


RESULTS
Both dance groups improved more than the control group, which did not improve. The tango and waltz/foxtrot groups improved significantly on the Berg Balance Scale, 6-minute walk distance, and backward stride length. The tango group improved as much or more than those in the waltz/foxtrot group on several measures.


CONCLUSION
Tango may target deficits associated with Parkinson's disease more than waltz/foxtrot, but both dances may benefit balance and locomotion.
Nursing Theory in Holistic Nursing Practice

Concept: An abstract idea or notion. Conceptual model: A group of interrelated concepts described to suggest relationships among them. Framework: A basic structure; the context in which theory is developed; the structure that permits theory to be understood. Grand theory: A theory that covers a broad area of the discipline’s concerns. Metaparadigm: Concepts that identify the domain of a discipline. Metatheory: Theory about theory development; theory about theory. Midrange theory: A focused theory for nursing that deals with a portion of nurses’ concerns or that is oriented to patient outcomes. Model: A representation of interactions between and among concepts. Nursing theory: A framework; a set of interrelated concepts that are testable; a way of Nursing Theory in Holistic Nursing Practice
Habermas and the Unfinished Project of Modernity: Critical Essays on the Philosophical Discourse of Modernity

Introduction, Maurizio Passerin d'Entreves - "Modernity Versus Postmodernity", J. Habermas. Part 1 Critical rejoinders: the discourse of modernity - Hegel, Nietzsche, Heidegger and Habermas, F. Dallmayr deconstruction, postmodernism and philosophy - Habermas on Derrida, C. Norris splitting the difference - Habermas's critique of Derrida, D. Hoy Habermas and Foucault, J. Schmidt intersubjectivity and the monadic core of the psyche - Habermas and Castoriadis on the unconscious, J. Whitebook. Part 2 Thematic reformulations: two versions of the linguistic turn - Habermas and poststructuralism, J. Bohman Habermas and the question of alterity, D. Coole the casuality of fate - modernity and modernism in Habermas, J.M. Bernstein the subject of justice in postmodern discourse - aesthetic judgment and political rationality, D. Ingram.
Progress in nonequilibrium quantum field theory III

We review recent developments and open questions for the description of nonequilibrium quantum fields, continuing hep-ph/0302210 and hep-ph/0410330 [J. Berges and J. Serreau in SEWM02, Ed. M.G. Schmidt, World Scientific, Singapore, 2003 [ arXiv:hep-ph/0302210 ]. SEWM04, Eds. K.J. Eskola, K. Kainulainen, K. Kajantie, K. Rummukainen, World Scientific, Singapore, 2005 [ arXiv:hep-ph/0410330 ]].
Arbitrary Analog/RF Spatial Filtering for Digital MIMO Receiver Arrays

Traditional digital multiple-input multiple-output (MIMO) receivers that feature element-level digitization face high instantaneous dynamic range challenges in the analog/RF domain due to the absence of analog/RF spatial filtering. Existing analog/RF spatial notch filtering techniques are limited in their noise, linearity, and spatial filtering bandwidth performance. More importantly, only single spatial notches have been demonstrated, providing insufficient filtering in practical scenarios. We propose a frequency-translational arbitrary spatial filtering technique that features not only arbitrary spatial filtering response generation at baseband for the protection of the following analog-to-digital converters, but modulated baseband input impedance that can be translated by passive mixers to achieve arbitrary spatial filtering at RF as well. This technique allows the synthesis and independent steering of an arbitrary number of spatial notches, and the independent adjustment of notch depths. Current-mode operation leads to superior linearity performance and ultra-wideband rejection. A four-element 65-nm CMOS 0.1–3.1 GHz prototype MIMO receiver array shows arbitrary spatial response formation, more than 50-dB spatial rejection across all measured directions, and an ultra-wide 320-MHz 20-dB rejection bandwidth for a single-notch setting at 500-MHz local oscillator (LO) frequency. Formation of a single spatial notch only moderately degrades the equivalent single-element double-sideband noise figure from 2.1–3.7 dB to 3.4–5.8 dB. In the notch direction, +34 dBV in-band output-referred IP3 is measured, an improvement of 33 dB compared with outside-notch directions. A wireless demonstration shows the receiver array demodulating a weak spatial signal in the presence of two strong in-band spatial signals, verifying the arbitrary spatial filtering functionality.
System structure for software fault tolerance

The paper presents, and discusses the rationale behind, a method for structuring complex computing systems by the use of what we term “recovery blocks”, “conversations” and “fault-tolerant interfaces”. The aim is to facilitate the provision of dependable error detection and recovery facilities which can cope with errors caused by residual design inadequacies, particularly in the system software, rather than merely the occasional malfunctioning of hardware components.
Exercise training enhances autonomic function after acute myocardial infarction: a randomized controlled study.

INTRODUCTION
Heart rate recovery, defined as the fall in heart rate during the first minute after exercise, is an indicator of autonomic function, and has been found to be an independent predictor of mortality after acute myocardial infarction. Exercise training has several well-known benefits in terms of cardiorespiratory fitness, modifiable cardiovascular risk factors and prognosis after acute coronary events. However, there are no randomized controlled studies in the literature evaluating the effects of exercise training per se, controlling for changes in medication and diet, on heart rate recovery. Thus, this study aims to assess the effects of exercise training on autonomic function in coronary artery disease patients recovering from acute myocardial infarction.


METHODS
Thirty-eight patients following a first acute myocardial infarction participated in this prospective randomized clinical trial. Patients were randomized into two groups: exercise training or control. The exercise group participated in an 8-week aerobic exercise program, while the control received standard medical care and follow-up. Changes in hemodynamics at rest and at peak exercise (heart rate, systolic and diastolic blood pressure, and rate pressure product), dietary intake, cardiorespiratory fitness, and heart rate recovery were assessed.


RESULTS
Medication and diet remained unchanged in both groups during the study period. The exercise-training group improved resting hemodynamics, particularly resting heart rate (from 68.0 ± 9.2 to 62.6 ± 8.7 bpm, p=0.030) and systolic blood pressure (from 135 ± 7.1 to 125.6 ± 11.3 mm Hg, p=0.012), cardiorespiratory fitness (from 30.8 ± 7.8 to 33.9 ± 8.3 ml/min/kg, p=0.016), and heart rate recovery (from 20 ± 6 to 24 ± 5 bpm, p=0.007). No significant changes were observed in the control group.


CONCLUSIONS
Exercise training improved autonomic function, assessed by heart rate recovery, resting heart rate and systolic blood pressure, in the absence of changes in diet or medication.
Patient priorities in osteoarthritis and comorbid conditions: a secondary analysis of qualitative data.

OBJECTIVE
A lack of agreement between clinician and patient priorities can impact the clinician-patient relationship, treatment concordance, and potential health outcomes. Studies have suggested that patients with osteoarthritis (OA) may prioritize comorbidities over their OA, but as yet no explicit systematic exploration of OA patients' priorities in relation to comorbidities exists. This study aims to explore how patients prioritize their OA among their conditions, which factors underlie this prioritization, and whether and why these priorities change over time.


METHODS
A secondary analysis of qualitative data was conducted utilizing 4 existing data sets collated from the 3 research centers involved. Purposive sampling provided a sample of 30 participants who all had OA and comorbidities. The research team collectively coded and analyzed the data thematically.


RESULTS
Three groups of patients emerged from the analysis. The 2 smaller groups had stable priorities (where OA was or was not prioritized) and illustrated the importance of factors, such as personal social context and the specific nature of the comorbid conditions. The third and largest group reported priorities that shifted over time. Shifting appeared to be influenced by the participants' perceptions of control and/or interactions with clinical professionals, and could have important consequences for self-management behavior.


CONCLUSION
The various factors underlying patients' priorities among their conditions, and the fluctuating nature of these priorities, highlight the importance of regular assessments during clinician-patient consultations to allow better communication and treatment planning, and ultimately optimize patient outcomes.
Marshall-Olkin generalized exponential distribution

Marshall and Olkin (1997, “A new method for adding a parameter to a family of distributions with applications to the exponential and Weibull families”, Biometrika, 641 652) introduced a new way of incorporating a parameter to expand a family of distributions. In this paper we adopt the Marshall-Olkin approach to introduce an extra shape parameter to the two-parameter generalized exponential distribution. It is observed that the new three-parameter distribution is very flexible. The probability density functions can be either a decreasing or an unimodal function. The hazard function of the proposed model, can have all the four major shapes, namely increasing, decreasing, bathtub or inverted bathtub types. Different properties of the proposed distribution have been established. The new family of distributions is analytically quite tractable, and it can be used quite effectively, to analyze censored data also. Maximum likelihood method is used to compute the estimators of the unknown parameters. Two data sets have been analyzed, and the results are quite satisfactory.
Fast and Robust Archetypal Analysis for Representation Learning

We revisit a pioneer unsupervised learning technique called archetypal analysis, [5] which is related to successful data analysis methods such as sparse coding [18] and non-negative matrix factorization [19]. Since it was proposed, archetypal analysis did not gain a lot of popularity even though it produces more interpretable models than other alternatives. Because no efficient implementation has ever been made publicly available, its application to important scientific problems may have been severely limited. Our goal is to bring back into favour archetypal analysis. We propose a fast optimization scheme using an active-set strategy, and provide an efficient open-source implementation interfaced with Matlab, R, and Python. Then, we demonstrate the usefulness of archetypal analysis for computer vision tasks, such as codebook learning, signal classification, and large image collection visualization.
The effect of cupric ion on the reaction inactivation of ascorbic acid oxidase.

Abstract 1. 1. The reaction inactivation of functioning ascorbic acid oxidase has been found to be greatly increased in the presence of free cupric ion, whereas the incubation of nonfunctioning enzyme with Cu ++ results in no apparent inactivation. 2. 2. Other bivalent metal ions (Fe ++ , Co ++ , Ni ++ , Zn ++ ) have been found to produce no significant retardation of the enzyme's action. 3. 3. It has been demonstrated that the increased enzyme inactivation in the presence of Cu ++ cannot be attributed to the formation of H 2 O 2 resulting from cupric ion catalysis of the aerobic oxidation of ascorbic acid. 4. 4. The significance of the Cu ++ effect in respect to the possible role of —SH group participation in the enzyme's function is briefly discussed.
Electroacupuncture for control of myeloablative chemotherapy-induced emesis: A randomized controlled trial.

CONTEXT
High-dose chemotherapy poses considerable challenges to emesis management. Although prior studies suggest that acupuncture may reduce nausea and emesis, it is unclear whether such benefit comes from the nonspecific effects of attention and clinician-patient interaction.


OBJECTIVE
To compare the effectiveness of electroacupuncture vs minimal needling and mock electrical stimulation or antiemetic medications alone in controlling emesis among patients undergoing a highly emetogenic chemotherapy regimen.


DESIGN
Three-arm, parallel-group, randomized controlled trial conducted from March 1996 to December 1997, with a 5-day study period and a 9-day follow-up.


SETTING
Oncology center at a university medical center.


PATIENTS
One hundred four women (mean age, 46 years) with high-risk breast cancer.


INTERVENTIONS
Patients were randomly assigned to receive low-frequency electroacupuncture at classic antiemetic acupuncture points once daily for 5 days (n = 37); minimal needling at control points with mock electrostimulation on the same schedule (n = 33); or no adjunct needling (n = 34). All patients received concurrent triple antiemetic pharmacotherapy and high-dose chemotherapy (cyclophosphamide, cisplatin, and carmustine).


MAIN OUTCOME MEASURES
Total number of emesis episodes occurring during the 5-day study period and the proportion of emesis-free days, compared among the 3 groups.


RESULTS
The number of emesis episodes occurring during the 5 days was lower for patients receiving electroacupuncture compared with those receiving minimal needling or pharmacotherapy alone (median number of episodes, 5, 10, and 15, respectively; P<.001). The electroacupuncture group had fewer episodes of emesis than the minimal needling group (P<.001), whereas the minimal needling group had fewer episodes of emesis than the antiemetic pharmacotherapy alone group (P =.01). The differences among groups were not significant during the 9-day follow-up period (P =.18).


CONCLUSIONS
In this study of patients with breast cancer receiving high-dose chemotherapy, adjunct electroacupuncture was more effective in controlling emesis than minimal needling or antiemetic pharmacotherapy alone, although the observed effect had limited duration. JAMA. 2000;284:2755-2761.