LLukas22/scidocs huggingface dataset:
Surface-enhanced copper bonding wire for LSI

There is growing interest in Cu wire bonding for LSI interconnection due to cost savings and better electrical and mechanical properties. Cu bonding wires, in general, are severely limited in their use compared to Au wires; such as wire oxidation, lower bondability, forming gas of N2+5%H2, and lower reliability. It is difficult for conventional bare Cu wires to achieve the target of LSI application. A surface-enhanced Cu wire (EX1) has been developed. It is a Pd-coated Cu wire and has many advantages compared to bare Cu wires. Stitch strength was much better under fresh conditions and maintained without any deterioration after being stored in air for a prolonged period of time. EX1 had a lifetime of over 90 days in air, although it was 7days for the bare Cu wire. Spherical balls were formed with pure N2 (hydrogen-free), whereas the bare Cu produced off-center balls. Cost-effective and secure gas, pure N2 was only available for EX1. The reliability for Cu wire bonding under conditions of high humidity was investigated in pressure cooker test (PCT). The lifetime for EX1 and the bare Cu was over 800h and 250h, respectively. Humidity reliability was significantly greater for EX1. Continuous cracking was formed at the bond interface for the bare Cu wire, although there was no cracking for EX1. Corrosion-induced deterioration would be the root cause of failure for bare Cu wires in PCT. EX1 improves the bond reliability by controlling diffusion at the bond interface. The excellent performance of Pd-coated Cu wire, EX1 is comparable with Au wires and suitable for LSI packaging.
Decoronation: An Alternative Treatment for Replacement Root Resorption

INTRODUCTION
Ankylosis and disrupted or altered root development are frequent complications associated with intrusive luxation and tooth avulsion lesions. Various forms of treatment have been described according to the severity of the trauma and root development. The literature shows that decoronation is an ideal treatment in cases where replacement resorption occurs.


METHODS
Two clinical cases are presented: involving intrusive luxation [15-year-old female patient with an affected maxillary left lateral incisor (2.2)] and a replanted avulsed tooth [8-year-old male patient with avulsion of the right maxillary central incisor (1.1)]; both cases presented advanced root resorption so that decoronation with a prosthetic tooth replacement was decided as the final treatment option.


RESULTS
In the short-term follow-up, patients were asymptomatic and had no functional problems. Radiographs showed that crestal bone height had been preserved.


CONCLUSIONS
Preserving the decoronated root in the alveolar process not only helps to maintain bone volume but also enables vertical bone growth and facilitates the future insertion of an implant.
The nondystrophic myotonias

The nondystrophic myotonias are a heterogeneous set of rare diseases that demonstrate clinical myotonia, electrical myotonia, or both. These disorders are distinguished from myotonic dystrophy type 1 (DM-1), the more recently described proximal myotonic myopathy/myotonic dystrophy type 2 (PROMM/DM-2), and proximal myotonic dystrophy (a variant of DM-2) by characteristic clinical features, lack of abnormal nucleotide repeat expansions in the DM-1 and DM-2 genes, lack of cataracts and endocrine disturbances, and absence of significant histopathology in the muscle biopsy. The present article reviews each of the nondystrophic myotonias by exploring the unique clinical features, electrodiagnostic findings, diagnostic criteria, gene mutations, and response to pharmacologic therapy. These diseases are divided into those with chloride channel dysfunction (the myotonia congenita disorders) and those with sodium channel dysfunction (paramyotonia congenita, potassium-aggravated myotonia, and hyperkalemic periodic paralysis with myotonia). The variants that occur in each of these conditions are commented on. The differentiating features of the nondystrophic myotonias are summarized, and their predominant clinical, electrodiagnostic, and genetic characteristics are tabulated. For a comprehensive review of pertinent research and studies with application to diagnosis and treatment of individuals with nondystrophic myotonic disorders, the present article is best read in the context of other articles in this issue, especially those on ion channel physiology (Cannon) and pharmacology (Conte-Camerino), and on hyperkalemic periodic paralysis (Lehmann-Horn).
Implementation of IoT system using block chain with authentication and data protection

In a block-chain IoT environment, when data or device authentication information is put on a block chain, personal information may be leaked through the proof-of-work process or address search. In this paper, we apply Zero-Knowledge proof to a smart meter system to prove that a prover without disclosing information such as public key, and we have studied how to enhance anonymity of block chain for privacy protection.
Learning DTW-Shapelets for Time-Series Classification

Shapelets are discriminative patterns in time series, that best predict the target variable when their distances to the respective time series are used as features for a classifier. Since the shapelet is simply any time series of some length less than or equal to the length of the shortest time series in our data set, there is an enormous amount of possible shapelets present in the data. Initially, shapelets were found by extracting numerous candidates and evaluating them for their prediction quality. Then, Grabocka et al. [2] proposed a novel approach of learning time series shapelets called LTS. A new mathematical formalization of the task via a classification objective function was proposed and a tailored stochastic gradient learning was applied. It enabled learning near-to-optimal shapelets without the overhead of trying out lots of candidates. The Euclidean distance measure was used as distance metric in the proposed approach. As a limitation, it is not able to learn a single shapelet, that can be representative of different subsequences of time series, which are just warped along time axis. To consider these cases, we propose to use Dynamic Time Warping (DTW) as a distance measure in the framework of LTS. The proposed approach was evaluated on 11 real world data sets from the UCR repository and a synthetic data set created by ourselves. The experimental results show that the proposed approach outperforms the existing methods on these data sets.
An HMM and structural entropy based detector for Android malware: An empirical study

Smartphones are becoming more and more popular and, as a consequence, malware writers are increasingly engaged to develop new threats and propagate them through official and third-party markets. In addition to the propagation vectors, malware is also evolving quickly the techniques adopted for infecting victims and hiding their malicious nature to antimalware scanning. From SMS Trojans to legitimate applications repacked with malicious payload, from AES encrypted root exploits to the dynamic loading of a payload retrieved from a remote server: malicious code is becoming more and more hard to detect. In this paper we experimentally evaluate two techniques for detecting Android malware: the first one is based on Hidden Markov Model, while the second one exploits structural entropy. These two techniques have been successfully applied to detect PCs viruses in previous works, and only one work in literature analyzes the application of HMM to the detection of Android malware. We demonstrate that these methods, which reveal effective for PCs virus, are also successful for detecting and classifying mobile malware. Our results are promising: we obtain a precision of 0.96 to discriminate a malware application, and a precision of 0.978 to identify the malware family. © 2016 Elsevier Ltd. All rights reserved.
Business and Social Networks in International Trade

Today . . . new transportation and communications technologies allow even the smallest firms to build partnerships with foreign producers to tap overseas expertise, cost-savings, and markets . . . The scarce resource in this new environment is the ability to locate foreign partners quickly and to manage complex business relationships across cultural and linguistic boundaries . . . [T]he Chinese and Indian entrepreneurs of Silicon Valley . . . are creating social structures that enable even the smallest producers to locate and maintain mutually beneficial collaborations across long distances. [AnnaLee Saxenian 1999, pp. 54–55]
A Review of the Relationship between Parental Involvement and Secondary School Students' Academic Achievement

This paper reviews the research literature on the relationship between parental involvement (PI) and academic achievement, with special focus on the secondary school (middle and high school) level. The results first present how individual PI variables correlate with academic achievement and then move to more complex analyses of multiple variables on the general construct described in the literature. Several PI variables with correlations to academic achievement show promise: (a) communication between children and parents about school activities and plans, (b) parents holding high expectations/aspirations for their children’s schooling, and (c) parents employing an authoritative parenting style. We end the results section by discussing the findings in light of the limitations of nonexperimental research and the different effects of children’s versus parents’ perspectives on academic achievement.
Insulin detemir improves glycaemic control without weight gain in insulin-naïve patients with type 2 diabetes: subgroup analysis from the PREDICTIVE study.

OBJECTIVE
Predictable Results and Experience in Diabetes through Intensification and Control to Target: an International Variability Evaluation (PREDICTIVE) is a multi-national, open-label, prospective, observational study assessing the safety and efficacy of insulin detemir in clinical practice. This post hoc subanalysis evaluates insulin-naïve patients on oral antidiabetic drugs (OADs) who were initiated on insulin detemir as basal therapy (+/- OADs).


METHODS
The European cohort of the PREDICTIVE study currently includes 20,531 patients (12,981 with type 2 diabetes) who were prescribed insulin detemir and followed up for 12, 26 or 52 weeks. Here, we report data from a subgroup of 2377 OAD-treated, insulin-naïve type 2 diabetes patients for a mean follow-up of 14.4 weeks. Patients were prescribed insulin detemir as basal therapy (+/- OADs) by their physician, as part of routine clinical care. Results were reported in comparison with baseline observations.


RESULTS
One serious adverse drug reaction was reported, which was a major hypoglycaemic episode. Treatment with insulin detemir (+/- OADs) significantly reduced mean haemoglobin A(1c) (HbA(1c)) (-1.3%; p < 0.0001), fasting glucose (-3.7 mmol/l; p < 0.0001), and within-patient fasting glucose variability (-0.5 mmol/l; p < 0.0001). In the majority of patients (82%), these improvements in glycaemic control were achieved with once daily administration of insulin detemir. There was a small reduction in mean body weight (-0.7 kg; p < 0.0001), which was most apparent in patients with a higher body mass index (BMI) at baseline. A significant negative relationship between weight change and baseline BMI was observed (greater the BMI, greater the weight reduction). Multiple regression analysis showed that BMI and HbA(1c) at baseline, and change in HbA(1c), were all predictors for weight change (p < 0.0001 for all), with BMI being the strongest predictor.


CONCLUSIONS
Patients with type 2 diabetes naïve to insulin can be effectively treated with once-daily insulin detemir (+/- OADs) to achieve improved glycaemic control with no adverse effect on weight and a low risk of hypoglycaemia. These short-term results are consistent with the findings of clinical trials.
The effects of introducing Tabata interval training and stability exercises to school children as a school-based intervention program.

Background Physical activities during leisure time as well as school hours have changed over the past few years, with adolescents being less physically active and adopting a sedentary lifestyle. Objective The overall objective of this mixed-methods study was to evaluate the feasibility of introducing a 4-min Tabata interval training into a lower secondary school context. A further aim was to evaluate the possible effects on: coordination, balance, and strength. Methods The study was conducted as an intervention study with a mixed-method approach. Forty-three children, aged 7-9 years, participated in the intervention group. Additionally, 13 children were recruited as a control group. The intervention itself was delivered by the teachers and was performed for 4-min every day in a classroom setting. All participants performed physical tests before and after the intervention period to evaluate the Tabata training. After the completion of the 6-week Tabata interval training, the four teachers were interviewed. Results The push-ups (p = 0.004), kneeling push-ups (p = 0.03), and standing long jump (p = 0.01) improved in the intervention group after 6 weeks. No differences were observed between the genders. The teachers experienced that it worked well to integrate the Tabata interval training in the classroom setting. Conclusion After 6 weeks, a school-based Tabata intervention program improved physical performance. The teachers saw no obstacles in including the Tabata intervention program in a classroom setting and pointed out several positive aspects such as an increased energy level and development in the children's movement patterns.
Treatment of Nevus of Ota by Q-Switched Ruby Laser

The effectiveness of the Q-switched ruby laser was investigated in 38 patients with nevus of Ota at more than 10 months after the first irradiation. In 14 patients who were followed-up for a mean of 25.2 months after the first treatment, the effectiveness was evaluated as ``excellent'' in eight patients (57%), ``good'' in four patients (28%), and ``fair'' in two patients (14%). The mean number of irradiation treatments was 7.3 in the ``excellent'' group, 4.2 in the ``good'' group, and 3.0 in the ``fair'' group. In 24 patients who were followed-up for a mean of 13.6 months after the first treatment, the effectiveness was evaluated as ``excellent'' in eight patients (33%), ``good'' in 12 patients (50%), and ``fair'' in four patients (16%). The mean number of irradiation treatments was 5.7 in the ``excellent'' group, 5.2 in the ``good'' group, and 2.5 in the ``fair'' group. Even after repetitive irradiations, good results without scarring were noted in all cases except one where a slight inverted scar was developed. The effective rate tended to be higher in patients who underwent more irradiation treatments and were observed for a longer period of time. Satisfactory cosmetic results were achieved after Q-switched ruby laser therapy for nevus of Ota.
BEE2: a high-end reconfigurable computing system

The Berkeley Emulation Engine 2 (BEE2) project is developing a reusable, modular, and scalable framework for designing high-end reconfigurable computers, including a processing-module building block and several programming models. Using these elements, BEE2 can provide over 10 times more computing throughput than a DSP-based system with similar power consumption and cost and over 100 times that of a microprocessor-based system.
Combination chemotherapy with gemcitabine and ifosfamide as second-line treatment in metastatic urothelial cancer. A phase II trial conducted by the Hellenic Cooperative Oncology Group.

PURPOSE
The aim of the study was to evaluate the efficacy and safety of the combination of gemcitabine and ifosfamide as a second-line treatment for advanced urothelial cancer.


PATIENTS AND METHODS
Thirty-four patients with metastatic urothelial cancer previously treated with cisplatin (CDDP)/ carboplatin (CBDCA) and/or taxanes-based chemotherapy were studied. Gemcitabine was administered at a dose of 800 mg/m2 on days 1 and 8 and ifosfamide at a dose of 2 g/m2 on days 1 and 8 with adequate amount of Mesna. every three weeks. Hematopoietic growth factors were given between days 3 to 5 and 12 to 16 to maintain the treatment schedule.


RESULTS
On an intent to treat basis, there was one complete response (CR) (3%) (95% confidence interval (95% CI): 0% to 10%) and six partial responses (PR) (18%) (95% CI: 7% to 34%). inducing an objective response rate (RR) of 21% (95% CI: 9% to 38%); 12 (35%) patients achieved a stable disease (SD) and 15 (44%) a progressive disease (PD). The median time to tumor progression (TTP) was four months (range, 0.52 to 21.6 months) and the median survival nine months (range 0.52 to 28 months). This regimen also provided the opportunity for symptomatic improvement of pain, dysuria, haematuria and leg oedema. Grade 3-4 neutropenia was experienced by 9 (27%) patients, grade 3 4 anemia by 6 (18%) and grade 3-4 thrombocytopenia by 4 (12%). Six patients were hospitalized due to febrile neutropenia. Despite the prophylactic use of hematopoietic growth factors, 8 (23.5%) patients required dose reduction due to myelosuppression. Grade 3 alopecia occurred in 14 (41%) patients, grade 3-4 nausea in 1 (3%), grade 2 fever in 3 (9%), grade 2-3 diarrhea in 2 ( 6%) and grade 2 allergic reaction in 1 (3%).


CONCLUSION
We conclude that the combination of gemcitabine and ifosfamide is an active salvage regimen for the treatment of urothelial cancer and that the treatment also has a tolerable toxicity profile; it warrants further investigation in combination with CDDP in chemotherapy-naïve patients.
Structure-properties relationship study in niobium oxide containing GaO3/2-LaO3/2-KO1/2 gallate glasses

Abstract The investigation has been devoted to the effect of the KNbO 3 in a gallate based glasses of composition (100-x) (69GaO 3/2 -11LaO 3/2 -20KO 1/2 ) – x KNbO 3 with x varying from 0 to 20 mol.% allowing the use of standard melt technique. The thermal and optical properties were characterized and the local structure has been investigated by Raman spectroscopy. The gallium ions are mostly found in tetrahedra thanks to charge balancing of potassium and lanthanum ions. The continuous increase of the KNbO 3 concentration gives rise to the progressive formation of a niobate subnetwork composed of corner shared NbO 6 octahedra which does not depolymerize the gallate glass network. This addition has a limited impact on the multiphonon edge in the infrared while it causes a significant increase of the refractive index. For KNbO 3 concentrations above 14 mol.% a phase separation occurs due to the absence of formation of a mixed gallo-niobate glass skeleton.
Online testable concept maps: benefits for learning about the pathogenesis of disease.

CONTEXT
Concept maps have been used to promote meaningful learning and critical thinking. Although these are crucially important in all disciplines, evidence for the benefits of concept mapping for learning in medicine is limited.


METHODS
We performed a randomised crossover study to assess the benefits of online testable concept maps for learning in pathology by volunteer junior medical students. Participants (n = 65) were randomly allocated to either of two groups with equivalent mean prior academic performance, in which they were given access to either online maps or existing online resources for a 2-week block on renal disease. Groups then crossed over for a 2-week block on hepatic disease. Outcomes were assessed using timed online quizzes, which included questions unrelated to topics in the pathogenesis maps as an internal control. Questionnaires were administered to evaluate students' acceptance of the maps.


RESULTS
In both blocks, the group with access to pathogenesis maps achieved significantly higher average scores than the control group on quiz questions related to topics covered by the maps (Block 1: p < 0.001, Cohen's d = 0.9; Block 2: p = 0.008, Cohen's d = 0.7). However, mean scores on unrelated questions did not differ significantly between the groups. In a third block on pancreatic disease, both groups received pathogenesis maps and collectively performed significantly better on quiz topics related to the maps than on unrelated topics (p < 0.01, Cohen's d = 0.5). Regression analysis revealed that access to pathogenesis maps was the dominant contributor to variance in performance on map-related quiz questions. Responses to questionnaire items on pathogenesis maps were overwhelmingly positive in both groups.


CONCLUSIONS
These results indicate that online testable pathogenesis maps are well accepted and can improve learning of concepts in pathology by medical students.
Efficient Probabilistic Reverse Nearest Neighbor Query Processing on Uncertain Data

Given a query object q, a reverse nearest neighbor (RNN) query in a common certain database returns the objects having q as their nearest neighbor. A new challenge for databases is dealing with uncertain objects. In this paper we consider probabilistic reverse nearest neighbor (PRNN) queries, which return the uncertain objects having the query object as nearest neighbor with a sufficiently high probability. We propose an algorithm for efficiently answering PRNN queries using new pruning mechanisms taking distance dependencies into account. We compare our algorithm to state-ofthe-art approaches recently proposed. Our experimental evaluation shows that our approach is able to significantly outperform previous approaches. In addition, we show how our approach can easily be extended to PRkNN (where k > 1) query processing for which there is currently no efficient solution.
Modification by Influenza on Health Effects of Air Pollution in Hong Kong

BACKGROUND
Both influenza viruses and air pollutants have been well documented as major hazards to human health, but few epidemiologic studies have assessed effect modification of influenza on health effects of ambient air pollutants.


OBJECTIVES
We aimed to assess modifying effects of influenza on health effects of ambient air pollutants.


METHODS
We applied Poisson regression to daily numbers of hospitalizations and mortality to develop core models after adjustment for potential time-varying confounding variables. We assessed modification of influenza by adding variables for concentrations of single ambient air pollutants and proportions of influenza-positive specimens (influenza intensity) and their cross-product terms.


RESULTS
We found significant effect modification of influenza (p < 0.05) for effects of ozone. When influenza intensity is assumed to increase from 0% to 10%, the excess risks per 10-microg/m(3) increase in concentration of O(3) increased 0.24% and 0.40% for hospitalization of respiratory disease in the all-ages group and >or= 65 year age group, respectively; 0.46% for hospitalization of acute respiratory disease in the all-ages group; and 0.40% for hospitalization of chronic obstructive pulmonary disease in the >or= 65 group. The estimated increases in the excess risks for mortality of respiratory disease and chronic obstructive pulmonary disease in the all-ages group were 0.59% and 1.05%, respectively. We found no significant modification of influenza on effects of other pollutants in most disease outcomes under study.


CONCLUSIONS
Influenza activity could be an effect modifier for the health effects of air pollutants particularly for O(3) and should be considered in the studies for short-term effects of air pollutants on health.
Finding and counting given length cycles

We present an assortment of methods for finding and counting simple cycles of a given length in directed and undirected graphs. Most of the bounds obtained depend solely on the number of edges in the graph in question, and not on the number of vertices. The bounds obtained improve upon various previously known results.