LLukas22/scidocs huggingface dataset:
Excretion of methamphetamine and amphetamine in human sweat following controlled oral methamphetamine administration.

BACKGROUND
Understanding methamphetamine (MAMP) and amphetamine (AMP) excretion in sweat is important for interpreting sweat and hair testing results in judicial, workplace, and drug treatment settings.


METHODS
Participants (n = 8) received 4 10-mg (low) oral doses of sustained-release S-(+)-MAMP HCl (d-MAMP HCl) within 1 week in a double-blind, institutional review board-approved study. Five participants also received 4 20-mg (high) doses 3 weeks later. PharmChek sweat patches (n = 682) were worn for periods of 2 h to 1 week during and up to 3 weeks after dosing. The mass of MAMP and AMP in each patch was measured by GC-MS, with a limit of quantification of 2.5 ng/patch.


RESULTS
MAMP was measurable in sweat within 2 h of dosing. After low and high doses, 92.9% and 62.5% of weekly sweat patches were positive, with a median (range) MAMP of 63.0 (16.8-175) and 307 (199-607) ng MAMP/patch, respectively; AMP values were 15.5 (6.5-40.5) and 53.8 (34.0-83.4) ng AMP/patch. Patches applied 2 weeks after the drug administration week had no measurable MAMP following the low doses, and only 1 positive result following the high doses. Using criteria proposed by the Substance Abuse Mental Health Services Administration, 85.7% (low) and 62.5% (high) weekly sweat patches from the dosing week were positive for MAMP, and all patches applied after the dosing week were negative.


CONCLUSIONS
These data characterize the excretion of MAMP and AMP after controlled MAMP administration and provide a framework for interpretation of MAMP sweat test results in clinical and forensic settings.
Energy comparison of MPPT techniques for PV Systems

Many maximum power point tracking techniques for photovoltaic systems have been developed to maximize the produced energy and a lot of these are well established in the literature. These techniques vary in many aspects as: simplicity, convergence speed, digital or analogical implementation, sensors required, cost, range of effectiveness, and in other aspects. This paper presents a comparative study of ten widely-adopted MPPT algorithms; their performance is evaluated on the energy point of view, by using the simulation tool Simulink®, considering different solar irradiance variations. Key-Words: Maximum power point (MPP), maximum power point tracking (MPPT), photovoltaic (PV), comparative study, PV Converter.
The measure of face-lift patient satisfaction: the Owsley Facelift Satisfaction Survey with a long-term follow-up study.

BACKGROUND
Patient satisfaction is a major factor in determining success in aesthetic surgery. To the authors' knowledge, a long-term study measuring patient satisfaction with face-lift surgery has not been published. The authors' study was designed to measure patient satisfaction with the overall experience of a face lift and to assess the patient's level of satisfaction 10 to 15 years after surgery.


METHODS
Three hundred ninety-four consecutive patients were identified who had face lifts performed by the senior author (J.Q.O.) between January 1, 1994, and January 1, 1999. Contact was achieved with 146 patients (37 percent), and 131 patients (90 percent) agreed to participate by completing a four-page survey. Eighty-nine patients (68 percent) returned the survey.


RESULTS
One year after face-lift surgery, 87 patients (97.8 percent) described the improvement of their facial appearance as very good or beyond expectations. After an average follow-up of 12.6 years, 61 patients (68.5 percent) rated their current degree of improvement as very good or beyond expectations, and 61 patients (68.5 percent) felt 10 or more years had been added to their youthful appearance. Thirty-four patients (31 percent) indicated disappointment in some aspect of the face lift.


CONCLUSIONS
This work assesses the long-term satisfaction of face-lift patients who had a superficial musculoaponeurotic system-platysma face lift. The results suggest a high degree of satisfaction following face-lift surgery at short-term and long-term follow-up. The authors recognize that recall bias may be present when recalling the satisfaction at 1 year postoperatively. We present the survey questionnaire as a template for future research in face-lift patients.
Lennox-Gastaut Syndrome: A State of the Art Review.

Lennox-Gastaut syndrome (LGS) is a severe age-dependent epileptic encephalopathy usually with onset between 1 and 8 years of age. Functional neuroimaging studies recently introduced the concept of Lennox-Gastaut as "secondary network epilepsy" resulting from dysfunctions of a complex system involving both cortical and subcortical structures (default-mode network, corticoreticular connections, and thalamus). These dysfunctions are produced by different disorders including hypoxic-ischemic encephalopathies, meningoencephalitis, cortical malformations, neurocutaneous disorders, or tumors. The list of etiologies was expanded to pathogenic copy number variants at whole-genome array comparative genomic hybridization associated with late-onset cases or pathogenic mutations involving genes, such as GABRB3, ALG13, SCN8A, STXBP1, DNM1, FOXG1, or CHD2. Various clinical trials demonstrated the usefulness of different drugs (including rufinamide, clobazam, lamotrigine, topiramate, or felbamate), ketogenic diet, resective surgery, corpus callosotomy, and vagus nerve stimulation in the treatment of epileptic manifestations. The outcome of LGS often remains disappointing regarding seizure control or cognitive functioning. The realization of animal models, which are still lacking, and the full comprehension of molecular mechanisms involved in epileptogenesis and cognitive impairment would give a relevant support to further improvements in therapeutic strategies for LGS patients.
A new finite volume scheme for anisotropic diffusion problems on general grids: convergence analysis

We introduce here a new finite volume scheme which was develop ed for the discretization of anisotropic diffusion problems; the originality of this scheme lies in the fact that we are able to prove its convergence under very weak assumption s on the discretization mesh. c © 2007 Académie des sciences/ Éditions scientifiques et médicales Elsevier SAS Un nouveau sch́ema volumes finis pour les probl èmes de diffusion anisotrope : analyse de convergence Résum é. On introduit ici un nouveau schéma volumes finis, construit pour la discrétisation de problèmes de diffusion anisotrope sur des maillages gén ́ eraux ; l’originalité de ce travail réside dans sa preuve de convergence, qui ne nécessite que des hypothèses faibles sur le maillage. c © 2007 Académie des sciences/ Éditions scientifiques et médicales Elsevier SAS
IBD: Sequential rescue therapy in steroid-refractory ulcerative colitis

Treatment of patients with steroid-refractory ulcerative colitis is still a challenge for physicians. A recent study has evaluated the effectiveness and safety of sequential rescue therapies in this subgroup of patients.
Estimation and calibration algorithms for distributed sampling systems

Distributed Sampling Systems by Vijay Divi S.B., Massachusetts Institute of Technology (2002) S.B., Massachusetts Institute of Technology (2003) M.Eng., Massachusetts Institute of Technology (2004) Submitted to the Department of Electrical Engineering and Computer Science in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Electrical Engineering and Computer Science at the MASSACHUSETTS INSTITUTE OF TECHNOLOGY September 2008 c ©Massachusetts Institute of Technology, 2008. All rights reserved.
High-dose Chemotherapy with Stem Cell Rescue as Initial Therapy for Anaplastic Oligodendroglioma

Purpose: Anaplastic oligodendroglioma is a chemosensitive glial neoplasm. To improve disease control and postpone cranial radiotherapy, we designed a phase II study of intensive procarbazine, lomunstine and vincristine followed by high-dose thiotepa with autologous stem cell rescue for patients with newly diagnosed anaplastic or aggressive oligodendroglioma. Patients and methods: Sixty-nine patients with a median age of 42 (range: 18–67) and a median Karnofsky Performance Score of 90 (range: 70–100) were enrolled. Sixteen patients had a prior diagnosis of low-grade oligodendroglioma and 16 had mixed oligoastrocytoma pathology. Only patients with demonstrably chemosensitive enhancing tumors or those free of enhancing tumor after surgery and induction therapy were eligible to receive high-dose thiotepa. Results: Thirty-nine patients (57%) completed the transplant regimen; their estimated median progression-free survival is 69 months and median overall survival has not been reached. Twelve transplanted patients (31%) relapsed. Neither histology nor prior low-grade oligodendroglioma correlated with relapse; however, persistent non-enhancing tumor at transplant conferred an increased risk of relapse (p = 0.028). The transplant regimen was well-tolerated; median hospital stay was 20 days (range: 7–43) with a median time to ANC and platelet engraftment of 10 days. Thirty patients (43%) did not receive high-dose thiotepa because of stable or progressive disease (n = 21), excessive toxicity (n = 4), refusal of further therapy (n = 2), failure to obtain insurance coverage (n = 2), or other (n = 1). No treatment-related or long-term neurotoxicity was seen in the transplanted patients. Conclusions: High-dose chemotherapy with stem cell rescue as initial treatment for anaplastic oligodendroglioma is feasible and associated with prolonged tumor control in some patients.
The pediatric template of brain perfusion

Magnetic resonance imaging (MRI) captures the dynamics of brain development with multiple modalities that quantify both structure and function. These measurements may yield valuable insights into the neural patterns that mark healthy maturation or that identify early risk for psychiatric disorder. The Pediatric Template of Brain Perfusion (PTBP) is a free and public neuroimaging resource that will help accelerate the understanding of childhood brain development as seen through the lens of multiple modality neuroimaging and in relation to cognitive and environmental factors. The PTBP uses cross-sectional and longitudinal MRI to quantify cortex, white matter, resting state functional connectivity and brain perfusion, as measured by Arterial Spin Labeling (ASL), in 120 children 7-18 years of age. We describe the PTBP and show, as a demonstration of validity, that global summary measurements capture the trajectories that demarcate critical turning points in brain maturation. This novel resource will allow a more detailed understanding of the network-level, structural and functional landmarks that are obtained during normal adolescent brain development.
Feasibility and Timing of Prehospital Administration of Reteplase in Patients with Acute Myocardial Infarction

Background: In myocardial infarction patients undergoing thrombolysis, treatment delays negatively impact outcomes. This pilot study was conducted to determine the feasibility and timing of field administration of intravenous double bolus reteplase in patients with ST-elevation myocardial infarction. Methods: Sixty three patients with symptoms and EKG changes consistent with acute myocardial infarction of less than six hours duration received the first bolus of reteplase before arriving at the emergency department. A second bolus of reteplase was given in the emergency department. Subsequent resolution of ST-segment elevation was measured. Mean time from symptom onset to paramedic dispatch, and paramedic arrivals to first bolus of reteplase were measured. The mean time from the first bolus of reteplase to heparin bolus in an emergency department was also measured. All patients with evidence of ST-elevation and suspected acute myocardial infarction gave consent for the thrombolytic therapy. There were no refusals of therapy among those candidates eligible for thrombolysis. Results: The mean times from the first bolus of reteplase to heparin bolus in the emergency department was substantially longer than the in-field times. Resolution of ST-segment elevation was recorded in 52 of the 63 patients and the times of resolution ranged from five minutes after the first bolus dose to 190 minutes after the second bolus of reteplase. Resolution of ST-segment elevation and relief of pain occurred almost simultaneously. Conclusions: These results demonstrated that in-field administration of thrombolytic therapy is a viable option to reduce the delay from symptom onset to initiation of thrombolysis. They demonstrated that satisfactory resolution of ST-segment elevation can be recorded in the field. The reduction in mortality observed in this study is comparable to previously published studies on inpatients. Abbreviated Abstract. This open-label pilot study was conducted to determine the feasibility and timing of field administration of intravenous double-bolus reteplase and to measure subsequent resolution of ST elevation in 63 patients with symptoms and ECG changes consistent with acute myocardial infarction for less than 6 hours. These results demonstrated that in-field administration of thrombolytic therapy is a viable option to reduce the delay from symptom onset to initiation of thrombolytic therapy.
The effect of high plasma levels of angiotensin-converting enzyme (ACE) and plasminogen activator inhibitor (PAI-1) on the reperfusion after thrombolytic therapy in patients presented with acute myocardial infarction

The resistance to thrombolytic agents and delays in reperfusion occur in more than 30% after acute myocardial infarction. This may play an important role in the unsuccessful recanalization after thrombolytic therapy. The aim of this study is to assess the clinical and biochemical markers of reperfusion after different types of thrombolytic therapy and to find out the relationship between PAI-1 and ACE serum levels and the short-term outcome. Pretreatment ACE and PAI-1 plasma levels of 184 patients with acute myocardial infarction, treated with thrombolytic therapy were determined. Failure of thrombolysis was considered when reperfusion was delayed as assessed by noninvasive reperfusion criteria, reinfarction, and impaired left ventricular function. High plasma level of ACE (> 50 U/L), PAI-1 (> 43 ng/ml) and both was found in 57, 108 and 32 patients respectively. Subjects with high ACE plasma levels were characterized by impaired LV systolic function (79.0% vs. 75.0%), new Q-wave (88.4% vs. 74.2%), less reperfusion arrhythmia (19.3% vs. 22.8%) and prolonged hospitalization (70% vs. 66%) but no statistical significance was observed. High enzymes levels of PAI-1 were observed with higher incidence of anterior myocardial infarction (50.0% vs. 41.0%), lesser ST segment resolution (65.6% vs. 58.8%), reinfarction (6.3% vs. 5.9%), and impaired LV systolic function (90.6% vs. 76.0%), and prolonged hospitalization (70.4% vs. 63.4). There was a statistically significant difference between thrombolytic agents in the presence of high ACE regarding hospital overstay (p = 0.02). While the presence of high PAI-1 was significantly affect the degree of ST-segment resolution (p = 0.03). Conclusion: High plasma ACE and/or PAI-1 plays a considerable role in the higher incidence of unsuccessful reperfusion and impaired left ventricular function after thrombolytic therapy. A rapid diagnostic tool that enables physician of detecting those enzymes before giving thrombolytic therapy may change the strategy of treatment to offer another effective revascularization method.
Loss of Pace Capture on the Ablation Line During Pulmonary Vein Isolation versus "Dormant Conduction": Is Adenosine Expendable?

INTRODUCTION
Permanent pulmonary vein isolation (PVI) remains an essential goal of ablation therapy in patients with atrial fibrillation. Aim of this study was the intraindividual comparison of unexcitability to pacing along the ablation line versus dormant conduction (DC) as additional procedural endpoints.


METHODS
A total of 58 patients with paroxysmal atrial fibrillation (PAF) underwent PVI by circumferential ablation of ipsilateral pulmonary veins (PVs), followed by testing for DC by adenosine administration. Irrespective of the presence of DC, pacing along the ablation line for left atrium capture was performed and additional radio frequency energy applied if necessary. PVs with initial DC were retested after achieving unexcitability.


RESULTS
PVI was achieved in 224 of 224 PVs. In 33 of 224 PVs (15%) DC was revealed. At 92 of 112 ablation lines (82%) sites of excitability were found. Three (9%) of the initial 33 PVs with DC showed further DC after achieving unexcitability at repeated testing. Thirty-two of 33 assumed areas of unmasked PV-LA reconduction as revealed by DC-testing showed a corresponding site of excitability on the ablation line. After a follow-up of 11.6 ± 3.4 months 79% of patients were free of arrhythmia.


CONCLUSIONS
Pacing for unexcitability can safely identify potential sites of DC and even sites that would have not been detected by testing for DC. Unexcitability, therefore, serves as a suitable and safe procedural endpoint not only for patients with contraindications to adenosine administration. Our data suggest that adenosine may be expendable when achieving unexcitability along the ablation line.
Is Money Supply the Cause of Inflation in India? An Alternative Postulate to Understand Inflation

Abstract ‘Inflation is always a monetary phenomenon’ say some economists and policymakers and attempt to arrest rising inflation with policies aimed at reducing the money supply in the economy. The theory is true in countries which have reached the full employment level, but in developing and underdeveloped countries this may not always be true. Advanced countries facing severe recession try to bring about inflation by raising money supply, and other advanced countries with high inflation pressure are able to successfully curtail inflation by reducing money supply. However, the entire inflation dynamics playing out in developing economies are different and it's necessary to re-visit and re-examine the relevance of the belief that inflation is always a monetary phenomenon, especially with respect to developing economies. The present research paper attempts to test the validity of the quantity theory of money in Indian situation and provide an alternative postulate.
Social media affects the timing, location, and severity of school shootings

Javier Garcia-Bernardo, ∗ Hong Qi, James M. Shultz, Alyssa M. Cohen, Neil F. Johnson, † and Peter Sheridan Dodds ‡ Department of Computer Science, University of Vermont, Burlington VT 05405, USA§ Department of Physics, University of Miami, Coral Gables, FL 33124, USA Center for Disaster & Extreme Event Preparedness (DEEP Center), University of Miami, Miller School of Medicine, FL 33124, USA 10858 Limeberry Drive, Cooper City, FL 33026, USA Department of Mathematics & Statistics, Vermont Complex Systems Center, Computational Story Lab, & the Vermont Advanced Computing Core, The University of Vermont, Burlington, VT 05401, USA§ (Dated: June 23, 2015)
Copula bivariate probit models: with an application to medical expenditures.

The bivariate probit model is frequently used for estimating the effect of an endogenous binary regressor (the 'treatment') on a binary health outcome variable. This paper discusses simple modifications that maintain the probit assumption for the marginal distributions while introducing non-normal dependence using copulas. In an application of the copula bivariate probit model to the effect of insurance status on the absence of ambulatory health care expenditure, a model based on the Frank copula outperforms the standard bivariate probit model.
Interacting with human physiology

We propose a novel system that incorporates physiological monitoring as part of the human–computer interface. The sensing element is a thermal camera that is employed as a computer peripheral. Through bioheat modeling of facial imagery almost the full range of vital signs can be extracted, including localize blood flow, cardiac pulse, and breath rate. This physiological information can then be used to draw inferences about a variety of health symptoms and psychological states. Our research aims to realize the notion of desktop health monitoring and create truly collaborative interactions in which humans and machines are both observing and responding. 2007 Elsevier Inc. All rights reserved.
Safety and Immunogenicity of DNA and MVA HIV-1 Subtype C Vaccine Prime-Boost Regimens: A Phase I Randomised Trial in HIV-Uninfected Indian Volunteers

STUDY DESIGN
A randomized, double-blind, placebo controlled phase I trial.


METHODS
The trial was conducted in 32 HIV-uninfected healthy volunteers to assess the safety and immunogenicity of prime-boost vaccination regimens with either 2 doses of ADVAX, a DNA vaccine containing Chinese HIV-1 subtype C env gp160, gag, pol and nef/tat genes, as a prime and 2 doses of TBC-M4, a recombinant MVA encoding Indian HIV-1 subtype C env gp160, gag, RT, rev, tat, and nef genes, as a boost in Group A or 3 doses of TBC-M4 alone in Group B participants. Out of 16 participants in each group, 12 received vaccine candidates and 4 received placebos.


RESULTS
Both vaccine regimens were found to be generally safe and well tolerated. The breadth of anti-HIV binding antibodies and the titres of anti-HIV neutralizing antibodies were significantly higher (p<0.05) in Group B volunteers at 14 days post last vaccination. Neutralizing antibodies were detected mainly against Tier-1 subtype B and C viruses. HIV-specific IFN-γ ELISPOT responses were directed mostly to Env and Gag proteins. Although the IFN-γ ELISPOT responses were infrequent after ADVAX vaccinations, the response rate was significantly higher in group A after 1(st) and 2(nd) MVA doses as compared to the responses in group B volunteers. However, the priming effect was short lasting leading to no difference in the frequency, breadth and magnitude of IFN-γELISPOT responses between the groups at 3, 6 and 9 months post-last vaccination.


CONCLUSIONS
Although DNA priming resulted in enhancement of immune responses after 1(st) MVA boosting, the overall DNA prime MVA boost was not found to be immunologically superior to homologous MVA boosting.


TRIAL REGISTRATION
Clinical Trial Registry CTRI/2009/091/000051.
Adsorption behaviour of copper and gold glycinates in alkaline media onto activated carbon. Part 1: Isotherms

Abstract The kinetics for the competitive adsorption of gold and copper onto activated carbon from synthetic alkaline glycine solutions was studied. The adsorption rate for both gold and copper at the initial stage was modelled using the Fleming k,n adsorption kinetic model. The coefficient of variation (R 2 ) of the model were close to unity for both gold and copper adsorption data. The effects of pH, free glycine, ionic strength, initial gold and copper concentrations and carbon concentration were assessed on the adsorption kinetics of these two metals. The results showed that >98% of gold was adsorbed onto activated carbon in 6 h or less under all studied conditions. According to the adsorption tests results, carbon concentration is the only parameter that significantly affected the initial gold adsorption rate. For all other studied parameters, the initial adsorption rate is quite robust, with a few variations in process conditions only affecting it slightly. Activated carbon was found to be very selective for gold glycinate complexes over copper glycinates, with over 99.0% gold adsorbed in 24 h and
Syntactic Clustering of the Web

We have developed an efficient way to determine the syntactic similarity of files and have applied it to every document on the World Wide Web. Using this mechanism, we built a clustering of all the documents that are syntactically similar. Possible applications include a “Lost and Found” service, filtering the results of Web searches, updating widely distributed web-pages, and identifying violations of intellectual property rights.