LLukas22/scidocs huggingface dataset:
An integrated service-device-technology roadmap for smart city development

Article history: Received 13 March 2012 Received in revised form 28 September 2012 Accepted 29 September 2012 Available online 13 November 2012 Firms and other organizations use Technology Roadmapping (TRM) extensively as a framework for supporting research and development of future technologies and products that could sustain a competitive advantage.While the importance of technology strategy has receivedmore attention in recent years, few research studies have examined how roadmapping processes are used to explore the potential convergence of products and services that may be developed in the future. The aim of this paper is to introduce an integrated roadmapping process for services, devices and technologies capable of implementing a smart city development R&D project in Korea. The paper applies a QFD (Quality Function Deployment) method to establish interconnections between services and devices, and between devices and technologies. The method is illustrated by a detailed case study, which shows how different types of roadmap can be coordinated with each other to produce a clear representation of the technological changes and uncertainties associated with the strategic planning of complex innovations. © 2012 Elsevier Inc. All rights reserved.
Abstraction Selection in Model-based Reinforcement Learning

ion Selection in Model-Based Reinforcement Learning Nan Jiang, Alex Kulesza, Satinder Singh {NANJIANG,KULESZA,BAVEJA}@UMICH.EDU Computer Science & Engineering, University of Michigan
Nursing practice environment, quality of care, and morale of hospital nurses in Japan.

The purpose of this study was to describe Japanese hospital nurses' perceptions of the nursing practice environment and examine its association with nurse-reported ability to provide quality nursing care, quality of patient care, and ward morale. A cross-sectional survey design was used including 223 nurses working in 12 acute inpatient wards in a large Japanese teaching hospital. Nurses rated their work environment favorably overall using the Japanese version of the Practice Environment Scale of the Nursing Work Index. Subscale scores indicated high perceptions of physician relations and quality of nursing management, but lower scores for staffing and resources. Ward nurse managers generally rated the practice environment more positively than staff nurses except for staffing and resources. Regression analyses found the practice environment was a significant predictor of quality of patient care and ward morale, whereas perceived ability to provide quality nursing care was most strongly associated with years of clinical experience. These findings support interventions to improve the nursing practice environment, particularly staffing and resource adequacy, to enhance quality of care and ward morale in Japan.
Towards task-independent person authentication using eye movement signals

We propose a person authentication system using eye movement signals. In security scenarios, eye-tracking has earlier been used for gaze-based password entry. A few authors have also used physical features of eye movement signals for authentication in a task-dependent scenario with matched training and test samples. We propose and implement a task-independent scenario whereby the training and test samples can be arbitrary. We use short-term eye gaze direction to construct feature vectors which are modeled using Gaussian mixtures. The results suggest that there are personspecific features in the eye movements that can be modeled in a task-independent manner. The range of possible applications extends beyond the security-type of authentication to proactive and user-convenience systems.
Flax Seed: A Potential Medicinal Food

Growing awareness about the role of diet and quest for human wellness has fuelled interest in ‘Functional foods’ and functional attributes of many traditional foods are being reinvented. Flax continues to surge forward in its recognition as a functional food and has recently gained attention in the area of cardiovascular disease primarily because it is the richest known source of alpha-linolenic acid, the phytoestrogen, lignans, as well as being a good source of soluble fiber. Lignans have diverse range of biological activities and flax seeds contain a lignin derivative, secoisolariciresinol diglucoside which get metabolized into the mammalian lignans. The flax lignans influence the early risk markers of mammary and colonic carcinogenesis in animal models. Regular consumption of flaxseed products can affect serum total and low-density lipoprotein cholesterol concentrations, reduce postprandial glucose absorption, decrease some markers of inflammation and raise serum levels of the omega-3 fatty acids, ALA and eicosapentaenoic acid. The flax seed has been shown to possess significant antioxidant and anti-inflammatory functions in experimental as well as human studies. The flax seed supplementation in diet revealed potential health benefits in situations like cardiovascular risk, certain types of cancers and other metabolic disorders. There are number of studies indicating the role of raw flaxseed and its baked products in health promotion and disease prevention. This review highlights the potential of ‘flax seed’ as a ‘neutraceutical’ and its role as a protective and therapeutic medicinal food.
Tuning of LTE main antenna using flexible tunable LC resonant circuitry

There have been an increasing trend in using metallic housing for mobile phone. The metallic housing can comes in many different forms ranging from a metal frame/rim that goes around the side of the mobile phone; to metal frame/rim with slots cut on it; to a full metallic back cover covering the back and side of the mobile phone. These metallic housing improves the outlook appearance of the mobile, and adds mechanical strength for the mobile phone. However, from the antenna point of view, such metallic housing often posts a great challenge towards the flexibility in designing the antenna and reduces the antenna sensitivity performance. This paper presents approaches of overcoming the challenges by introducing Tunable Circuitry that can be applied on both Aperture Tuning and Impedance Matching of the antenna in mobile phone with metallic back cover.
Phytochemical, Antibacterial And Cytotoxic Evaluation Of Raphiostylis Beninensis [Hook F. Ex Planch] Stem Bark Extracts

Methanol and ethyl acetate (stem-bark) extracts of Raphiostylis beninensis were investigated for their phytochemical, antibacterial and cytotoxic properties. Phytochemical analysis of ethyl acetate extracts of R. beninensis revealed alkaloids (1.10 ± 0.20 mg/kg), flavonoids (6.10 ± 0.10 mg/kg), saponins (5.30 ±0.15 mg/kg) and tannins (2.10 ± 0.20 mg/kg). Methanol of extract R. beninensis contained alkaloids (1.50 ±0.10 mg/kg), flavonoids (6.24 ± 0.20 mg/kg), saponins (7.50 ±0.10 mg/kg) and tannins (1.32 ± 0.03 mg/kg). The stem bark methanol and ethyl acetate extracts of Raphiostylis beninensis inhibited all tested strains Escherichia coli, Bacillus subtilis, Salmonella typhii and Staphyllococcus aureus at 20 mg/ml and 50 mg/ml respectively. The brine shrimp lethality test on the methanol and ethyl acetate extracts of Raphiostylis beninensis revealed cytotoxic activities with LC50 of 3.20 and 2.50 μg/ml. LASISI, A. A. Department of Chemistry, University of Agriculture, Abeokuta, Ogun State, Nigeria.
Nuclear Receptor CAR Represses TNFα-Induced Cell Death by Interacting with the Anti-Apoptotic GADD45B

BACKGROUND
Phenobarbital (PB) is the most well-known among numerous non-genotoxic carcinogens that cause the development of hepatocellular carcinoma (HCC). PB activates nuclear xenobiotic receptor Constitutive Active/Androstane Receptor (CAR; NR1I3) and this activation is shown to determine PB promotion of HCC in mice. The molecular mechanism of CAR-mediated tumor promotion, however, remains elusive at the present time. Here we have identified Growth Arrest and DNA Damage-inducible 45beta (GADD45B) as a novel CAR target, through which CAR represses cell death.


METHODOLOGY/PRINCIPAL FINDINGS
PB activation of nuclear xenobiotic receptor CAR is found to induce the Gadd45b gene in mouse liver throughout the development of HCC as well as in liver tumors. Given the known function of GADD45B as a factor that represses Mitogen-activated protein Kinase Kinase 7 - c-Jun N-terminal Kinase (MKK7-JNK) pathway-mediated apoptosis, we have now demonstrated that CAR interacts with GADD45B to repress Tumor Necrosis Factor alpha ( TNFalpha)-induced JNK1 phosphorylation as well as cell death. Primary hepatocytes, prepared from Car(+/+), Car(-/-), Gadd45b(+/+) and Gadd45b(-/-) mice, were treated with TNFalpha and Actinomycin D to induce phosphorylation of JNK1 and cell death. Co-treatment with the CAR activating ligand TCPOBOP (1,4 bis[2-(3,5-dichloropyridyloxy)]benzene) has resulted in repression of both phosphorylation and cell death in the primary hepatocytes from Car(+/+) but not Car(-/-) mice. Repression by TCPOBOP was not observed in those prepared from Gadd45b(-/-) mice. In vitro protein-protein interaction and phosphorylation assays have revealed that CAR interacts with MKK7 and represses the MKK7-mediated phosphorylation of JNK1.


CONCLUSIONS/SIGNIFICANCE
CAR can form a protein complex with GADD45B, through which CAR represses MKK7-mediated phosphorylation of JNK1. In addition to activating the Gadd45b gene, CAR may repress death of mouse primary hepatocytes by forming a GADD45B complex and repressing MKK7-mediated phosphorylation of JNK1. The present finding that CAR can repress cell death via its interaction with GADD45B provides an insight for further investigations into the CAR-regulated molecular mechanism by which PB promotes development of HCC.
BOURDIEU AND EDUCATION: HOW USEFUL IS BOURDIEU'S THEORY FOR RESEARCHERS?

Bourdieu and Education: How Useful is Bourdieu's Theory for Researchers?
Artificial Neural Network Based Spectrum Sensing Method for Cognitive Radio

Spectrum sensing is a key technology of cognitive radio (CR). In CR systems, the main requirement of spectrum sensing is the ability of rapid and accurate detection of the presence of the primary user. In this paper, we propose a spectrum sensing method using artiﬁcial neural network (ANN). Detailed analysis shows that the proposed scheme is appropriate to detect the signals under considerably low signal-to-noise ratio (SNR) environment and has reliable performance. Simulations also illustrate that the discussed method outperforms over previous approaches in noisy environment when sensing the spectrum for CR systems.
Garlic powder, effect on plasma lipids, postprandial lipemia, low-density lipoprotein particle size, high-density lipoprotein subclass distribution and lipoprotein(a).

OBJECTIVES
To test the hypothesis that a garlic supplement alters plasma lipoproteins, postprandial lipemia, low-density lipoprotein (LDL) size and high-density lipoprotein (HDL) subclass distribution differently in 50 moderately hypercholesterolemic subjects classified as LDL subclass pattern A or B.


BACKGROUND
Garlic has been variably reported to reduce or not affect plasma cholesterol values. Low-density lipoprotein pattern B is a common inherited disorder of lipoprotein metabolism that has been shown to have a significantly greater response to several lipid lowering treatments including low fat diet when compared with LDL pattern A individuals.


METHODS
A double blind, randomized, placebo controlled trial in an outpatient lipid research clinic was performed and included fifty moderately hypercholesterolemic subjects (mean LDL cholesterol = 166 +/- 22 mg/dl) classified as LDL subclass pattern A (predominantly large LDL, n = 22) or B (predominantly small LDL, n = 28). Following a two-month stabilization period, subjects were randomly assigned to a placebo or 300 mg three times a day of a standardized garlic tablet for three months.


RESULTS
For all subjects, LDL pattern A and B subjects combined, garlic treatment for three months resulted in no significant change in total cholesterol, LDL cholesterol, HDL cholesterol, HDL subclass distribution, postprandial triglycerides, apolipoprotein B, lipoprotein (a) (Lp[a]), LDL peak particle diameter or LDL subclass distribution. There was no significant difference in response for the same parameters among subjects classified as LDL pattern A or B with the exception of significantly greater (p = 0.01) reduction in mean peak particle diameter in pattern A subjects treated with either garlic or placebo. There was no significant change in LDL subclass distribution.


CONCLUSIONS
This investigation confirms that garlic therapy has no effect on major plasma lipoproteins and further, that it has no impact on HDL subclasses, Lp(a), apolipoprotein B, postprandial triglycerides or LDL subclass distribution. Garlic may have a greater effect on LDL particle diameter in LDL pattern A compared with pattern B subjects. This difference was not reflected in other plasma lipid measurements.
Adverse Selection, Slow Moving Capital and Misallocation

We embed adverse selection into a dynamic, general equilibrium model with heterogeneous capital and study its implications for aggregate dynamics. The friction leads to delays in firms’ divestment decisions and thus slow recoveries from shocks, even when these shocks do not affect the economy’s potential output. The impediments to reallocation increase with the dispersion in productivity and decrease with the interest rate, the frequency of sectoral shocks, and households’ consumption smoothing motives. When households are risk averse, delaying reallocation serves as a hedge against future shocks, which can lead to persistent misallocation. Our model also provides a micro-foundation for convex adjustment costs and a link between the nature of these costs and the underlying economic environment. © 2016 Elsevier B.V. All rights reserved. ✩ We are grateful to Andy Atkeson, Marty Eichenbaum, Andrea Eisfeldt, Joao Gomes, Zhiguo He, Pierre-Olivier Gourinchas, Boyan Jovanovic, Arvind Krishnamurthy, Lars-Alexander Kuehn, Pablo Kurlat, Stavros Panageas, Adriano Rampini, Lukas Schmid, Amit Seru, Andrzej Skrzypacz, and Vish Vishwanathan for useful comments and feedback. We also thank conference participants at the Duke-University of North Carolina Asset Pricing Conference, European Summer Symposium in Financial Markets, Foundation for the Advancement of Research in Financial Economics, National Bureau of Economic Research, Texas Finance Festival, Society of Economic Dynamics, and Stanford Institute of Theoretical Economics. Finally, we thank seminar participants at University of California at Berkeley, University of Chicago, Duke University, Ecole Polytechnique Fédérale de Lausanne, MIT Sloan School of Management, Northwestern University, San Francisco Federal Reserve, Toulouse School of Economics, University of British Columbia, University of California at Los Angeles, and Washington University in St. Louis for useful conversations and comments. We are grateful to Andreas Neuhierl for excellent research assistance. William Fuchs acknowledges support from the National Science Foundation (Grant 1260890 ). ∗ Corresponding author. Tel.: +1 510 643 1421; fax: +1 510 643 1412. E-mail addresses: wfuchs@berkeley.edu (W. Fuchs), greenb@berkeley.edu (B. Green), d-papanikolaou@kellogg.northwestern.edu
A phase I / II trial of iodine-131 – tositumomab ( anti-CD 20 ) , etoposide , cyclophosphamide , and autologous stem cell transplantation for relapsed B-cell lymphomas

Relapsed B-cell lymphomas are incurable with conventional chemotherapy and radiation therapy, although a fraction of patients can be cured with high-dose chemoradiotherapy and autologous stemcell transplantation (ASCT). We conducted a phase I/II trial to estimate the maximum tolerated dose (MTD) of iodine 131 (131I)–tositumomab (anti-CD20 antibody) that could be combined with etoposide and cyclophosphamide followed by ASCT in patients with relapsed B-cell lymphomas. Fifty-two patients received a trace-labeled infusion of 1.7 mg/kg 131Itositumomab (185-370 MBq) followed by serial quantitative gamma-camera imaging and estimation of absorbed doses of radiation to tumor sites and normal organs. Ten days later, patients received a therapeutic infusion of 1.7 mg/kg tositumomab labeled with an amount of 131I calculated to deliver the target dose of radiation (20-27 Gy) to critical normal organs (liver, kidneys, and lungs). Patients were maintained in radiation isolation until their total-body radioactivity was less than 0.07 mSv/h at 1 m. They were then given etoposide and cyclophosphamide followed by ASCT. The MTD of 131Itositumomab that could be safely combined with 60 mg/kg etoposide and 100 mg/kg cyclophosphamide delivered 25 Gy to critical normal organs. The estimated overall survival (OS) and progressionfree survival (PFS) of all treated patients at 2 years was 83% and 68%, respectively. These findings compare favorably with those in a nonrandomized control group of patients who underwent transplantation, external-beam total-body irradiation, and etoposide and cyclophosphamide therapy during the same period (OS of 53% and PFS of 36% at 2 years), even after adjustment for confounding variables in a multivariable analysis. (Blood. 2000;96:2934-2942)
Using BNP to develop a risk score for heart failure in primary care.

AIMS
Chronic heart failure is a common condition with high mortality. Accurate diagnosis in primary care is difficult. Elevated B-type natriuretic peptide (BNP) is associated with left ventricular systolic dysfunction and increased mortality. Prognostic scoring systems using BNP may help to stratify risk in primary care patients. The aim of this research was to establish the independent variables which predict mortality in a primary care population-prescribed loop diuretics and to generate and validate a scoring system for heart failure in general practice.


METHODS AND RESULTS
Five hundred and thirty-two patients were followed up for a mean of 6.4 years after attending a research clinic for clinical assessment, electrocardiogram (ECG), echocardiography, and BNP. Multivariate analysis was used to establish independent prognostic variables and to generate a prognostic scoring system. The score generated was [0.50 x BNP+5 x age+50 x (CVA+sex+diabetes+ECG)]. The cut-off scores for risk groups were; 25th percentile, 411; 50th percentile, 475; 75th percentile, 524; Harrell's c=0.75.


CONCLUSION
Developing prognostic scoring systems provides a means of risk stratifying patients without relying on a single cut-off diagnostic value for BNP. Further validation of such scoring systems may improve future management of community heart failure patients.
Prescription Drugs Used in Insomnia.

The scope of this article is to review the effects on sleep of prescription drugs that are commonly prescribed for chronic insomnia in adults. The following groups are discussed: benzodiazepines and its receptor agonists, the dual orexin receptor antagonist suvorexant, melatonin and its receptor agonists, sedating antidepressants, and antipsychotics. Together with the neurobiologic and pharmacologic properties of these drugs, clinical effects are described, including subjective and objective effects on sleep duration, continuity, and architecture. Medical prescription information is given when available. Recently published American and European guidelines for the treatment of insomnia serve as reference frame.
On-Line Mobile Robot Model Identification Using Integrated Perturbative Dynamics

We present an approach to the problem of real-time identification of vehicle motion models based on fitting, on a continuous basis, parametrized slip models to observed behavior. Our approach is unique in that we generate parametric models capturing the dynamics of systematic error (i.e. slip) and then predict trajectories for arbitrary inputs on arbitrary terrain. The integrated error dynamics are linearized with respect to the unknown parameters to produce an observer relating errors in predicted slip to errors in the parameters. An Extended Kalman filter is used to identify this model on-line. The filter forms innovations based on residual differences between the motion originally predicted using the present model and the motion ultimately experienced by the vehicle. Our results show that the models converge in a few seconds and they reduce prediction error for even benign maneuvers where errors might be expected to be small already. Results are presented for both a skid-steered and an Ackerman steer vehicle.
Exploring Optimizations to Paragraph Vectors

This paper replicates the results of Dai, Olah, and Le’s paper ”Document Embedding with Paragraph Vectors” and compares the performance of three unsupervised document modeling algorithms [1]. We built and compared the results of Paragraph Vector, Latent Dirichlet Allocation, and traditional Word2Vec models on Wikipedia browsing. We then built three extensions to the original Paragraph Vector model, finding that combinations of paragraph structures assist in optimizing Paragraph Vector training.
Contribution of sedative-hypnotic agents to delirium via modulation of the sleep pathway

PURPOSE
To review the mechanisms of sedative-hypnotic action with respect to the risk of delirium imparted by drugs that act on γ-amino-butyric-acid type A receptors or α(2) adrenoceptors.


SOURCE
MEDLINE was searched for relevant articles.


PRINCIPAL FINDINGS
Development of the acute confusional state of delirium is associated with longer intensive care unit (ICU) and hospital lengths of stay, significantly higher risk of functional decline, and increased mortality. Disruption of sleep is a modifiable risk factor that may contribute to delirium and cognitive dysfunction in ICU patients. Among the functions of sleep are repair of defective processes and restoration of the brain to a state in which it is ready to acquire new knowledge. It is logical that disruption of these processes may produce acute confusion. Delirium develops through a complex interaction between the patient's baseline vulnerability (patient's predisposing risk factors before hospitalization) and precipitating factors or insults (modifiable events that occur during hospitalization). The latter factors include both sleep disruption and sedation. We present a hypothesis that these two factors are causally linked through effects on memory. Our hypothesis explains why patients randomized to receive an α(2) adrenoceptor agonist are less likely to develop delirium (and the attendant cognitive dysfunction) than those randomized to receive benzodiazepines.


CONCLUSION
Herein we present our hypothesis that alternate mechanisms of hypnotic action may differentiate the deleriogenic properties of the two classes of sedatives. Future studies should focus on whether a causal relationship can be established between sedative administration, sleep disruption, and delirium.
Occupational Stress and Professional Burnout in Teachers of Primary and Secondary Education: The Role of Coping Strategies

This research investigates the levels of occupational stress and professional burnout of teachers of primary and secondary education. It also aims to investigate the coping strategies that they adopt, and the relationship between them. The survey involved 388 teachers who teach in public schools in Attica. Three instruments were administrated to teachers: “Teachers’ Occupational Stress” (Antoniou, Polychroni, & Vlachakis, 2006), the Maslach Burnout Inventory (Maslach & Jackson, 1986) and the “Stress Coping Strategies Scale” (Cooper, Sloan, & Williams, 1988). The findings showed that teachers of Primary Education experience higher levels of stress compared to the teachers of Secondary Education. Female teachers experience more stress and lower personal accomplishment than men. Rational coping behaviors are a resource which help teachers overcome work-related stressors and burnout and achieve their valued outcomes with students, while avoidance coping predicted high level of stress and burnout.