LLukas22/scidocs huggingface dataset:
Quality of life and femoral neck fractures.

The worldwide increase in hip fractures is a major challenge to the health care system and society. The proper treatment of femoral neck fractures in the elderly is still controversial, and even more so from an international perspective. Optimising the treatment for improved outcomes and a reduced need for secondary surgery is mandatory for humanitarian and economical reasons. The importance of incorporating the patient's perspective of the outcome in clinical trials has been acknowledged and there are now numerous instruments for assessing the quality of life. We evaluated two quality of life instruments, the EQ-5D and the SF-36, in patients with femoral neck fractures and also measured the quality of life two years after different interventions. The EQ-5D was validated in two prospective studies and it appeared to be an appropriate quality of life instrument in elderly patients with femoral neck fractures. There was a good correlation between the quality of life (EQ-5Dindexscores) and other outcome measures such as pain, mobility and independence in activities of daily living (ADL). The results also showed high responsiveness, i.e., ability to capture clinically important changes, for both the EQ-5D and the SF-36. The questionnaire response rate for both instruments was high. The rated prefracture EQ-5Dindexscores showed good correspondence with the scores of an age-matched Swedish reference population. The quality of life in patients with femoral neck fractures treated with internal fixation (IF) decreased, particularly in patients with fracture healing complications. The fracture healing complications rate at two years in patients with displaced femoral neck fractures treated with IF was 36% compared with 7% in patients with undisplaced fractures. The quality of life of patients with uneventfully healed fractures at two year was lower in patients with primary displaced fractures than in patients with primary undisplaced fractures. In a prospective randomised trial, patients with displaced femoral neck fractures were randomised to IF or total hip replacement (THR). IF resulted in more complications than THR, 36% versus 4%, and necessitated more reoperations, 42% versus 4%. Hip function and quality of life (EQ-5D) were generally better in the THR group. In summary, THR yielded a better outcome than IF for an elderly, relatively healthy, lucid patient with a displaced femoral neck fracture. In a study of elderly women with femoral neck fractures, nearly half of the patients displayed signs of protein-energy malnutrition. Underweight was associated with muscle fatigue, cognitive dysfunction and a low quality of life (Nottingham Health Profile). In a prospective randomised trial, protein-rich liquid supplementation in combination with an anabolic steroid given for 6 months to lean elderly women after a femoral neck fracture was shown to positively affect lean body mass, ADL and quality of life (EQ-5D). Fracture healing complications had a negative impact on body weight, lean body mass and quality of life.
Evolution in the design and construction of stadiums

Stadiums have carried through time, from ancient to modem, a common identity in the design concept, reflected through similarities in shape, structural elements, materials and methods of construction. The earliest design models appeared with the Greeks starting the eighth century B.C. and were improved by the Romans during the first four centuries A.D. The Colosseum, Roman's most acclaimed amphitheater is regarded as the mother of all modem stadiums, setting the rule for innovative design and construction. It generated the first stadium designs of the modem era and guided the evolution of their successors to the level of beauty and sophistication they actually reflect. This thesis presents the Colosseum as a case study for the identification and analysis of the major aspects of ancient stadiums design and construction methods following the model of Roman Engineering. Moving on towards the last two centuries, the Colosseum will be a guide to trace the evolution in the structural types of stadiums urged by the emergence of new construction materials and techniques in the flow of technological development. Thesis Supervisor: Jerome J. Connor, Jr. Title: Professor of Civil and Environmental Engineering
Transcriptome Analysis Describing New Immunity and Defense Genes in Peripheral Blood Mononuclear Cells of Rheumatoid Arthritis Patients

BACKGROUND
Large-scale gene expression profiling of peripheral blood mononuclear cells from Rheumatoid Arthritis (RA) patients could provide a molecular description that reflects the contribution of diverse cellular responses associated with this disease. The aim of our study was to identify peripheral blood gene expression profiles for RA patients, using Illumina technology, to gain insights into RA molecular mechanisms.


METHODOLOGY/PRINCIPAL FINDINGS
The Illumina Human-6v2 Expression BeadChips were used for a complete genome-wide transcript profiling of peripheral blood mononuclear cells (PBMCs) from 18 RA patients and 15 controls. Differential analysis per gene was performed with one-way analysis of variance (ANOVA) and P values were adjusted to control the False Discovery Rate (FDR<5%). Genes differentially expressed at significant level between patients and controls were analyzed using Gene Ontology (GO) in the PANTHER database to identify biological processes. A differentially expression of 339 Reference Sequence genes (238 down-regulated and 101 up-regulated) between the two groups was observed. We identified a remarkably elevated expression of a spectrum of genes involved in Immunity and Defense in PBMCs of RA patients compared to controls. This result is confirmed by GO analysis, suggesting that these genes could be activated systemically in RA. No significant down-regulated ontology groups were found. Microarray data were validated by real time PCR in a set of nine genes showing a high degree of correlation.


CONCLUSIONS/SIGNIFICANCE
Our study highlighted several new genes that could contribute in the identification of innovative clinical biomarkers for diagnostic procedures and therapeutic interventions.
CHNAGES IN GLOBAL ENVIRONMENT AND TASKS IN THE COASTAL ZONE

The activities of the Coastal Engineering Committee, JSCE, are introduced focusing on the global environment-related issues. A research sub-committee has been working to study the possible impacts of sea-level rise and climate change on the coastal zone since its establishment in 1992. After published a comprehensive report on the sea-level rise and climate chnage, it started the second stage of the study which aimes to identify the tasks and problems necessary for achieving the goals to create and preserve safety, atractive, and environmentally healthy coastal zones. Such goals are closely related to the sustainable development, which is also a basic concept fot the strategic responses to the global chnages in environment. KEY WORDS; coastal engineering, natural disaster prevention, utilization of coastal zone, preservation of natural environment, coastal zone management, global warming, sea-level rise, response strategy 1.海 岸工学委員会の取組み 沿岸域にもっとも関係の深い地球規模環境問題は温暖化であろ う.温 暖化によって海面上昇が加速す ると, 砂浜やサンゴ礁,マ ングローブなどの 自然環境 と沿岸都市や港湾,防 災施設をは じめ社会経済活動に様々な 影響が生 じると懸念 されている.さ らに,台 風や降雨パターンの変化が重なるとより深刻な問題に直面する 国や地域が現れると思われ る.地 球規模の環境問題 に関連 した海岸工学の課題は,こ れ らの現象の実態の把 握,影 響の予測 ・評価,そ して,対 応策の検討の3点 にまとめられよ う.80年 代末か ら90年代初めにかけて地 球規模の環境問題が一挙に注目を浴び,こ れ らの懸念が吹きだ したことか ら,海 岸工学委員会では組織だっ た研究を始めた. 1.1第1期 の活動 海岸工学委員会では,1991年4月 から 「地球規模環境問題研究小委員会」を組織 して,海 岸工学に関連 した 地球規模環境問題の研究に取 り組んだ.52名 のメンバーによる2年間の研究成果は 「地球温暖化の沿岸影響― 海面上昇 ・気候変動の実態 ・影響 ・対応戦略一」にまとめられ,1994年7月 に土木学会か ら出版 された(土 木 学会海岸工学委員会,1994). 1東 北 大 学 工 学 部 土 木 港 学 科D ept. of Civil Eng., Fac. of Eng., Tohoku Univ., 2茨 城 大 学 工 学 部 都 市 シ ス テ ム 工 学 科Dept. of Urban and Civil Eng., Fac. of Eng., Ibaraki Univ., 3大 阪 大 学 工 学 部 土 木 工 学 科Dept. of Civil Eng., Fac. of Eng., Osaka Univ., 4大 成 建 設(株)技 術 研 究 所Technology Research Center, Taisei Co., 5九 州 共 立 大 学 工 学 部 土 木 工 学 科Dept. of Civil Eng., Fac. of Eng., Kyushu Kyoritsu Univ.
Modeling user search behavior

Web usage mining is a main research area in Web mining focused on learning about Web users and their interactions with Web sites. Main challenges in Web usage mining are the application of data mining techniques to Web data in an efficient way and the discovery of non trivial user behaviour patterns. In this paper we focus the attention on search engines analyzing query log data and showing several models about how users search and how users use search engine results.
Prediction-Based Topology Control and Routing in Cognitive Radio Mobile Ad Hoc Networks

Recent research activities on cognitive radio (CR) have mainly focussed on opportunistic spectrum access and spectrum utilization. However, CR technology will have a significant impact on upper layer performance in wireless networks, particularly in mobile ad hoc networks (MANETs). In this paper, we study topology control and routing issues in CR-MANETs and propose a distributed prediction-based cognitive topology control (PCTC) scheme to provision cognition capability to routing in CR-MANETs. PCTC is a middleware-like cross-layer module residing between CR module and routing. It uses cognitive link availability prediction, which is aware of the interference to primary users and user mobility, to predict the available duration of links. Based on the link prediction, PCTC captures the dynamic changes of the topology and constructs an efficient and reliable topology, which is aimed at mitigating rerouting frequency and improving end-to-end network performance such as throughput and delay. Simulation results are presented to show the effectiveness of the proposed scheme.
Spontaneous Rupture of the Imperforate Hymen in an Adolescent  Girl with Hematocolpometra

Background. Imperforate hymen is usually treated with hymenotomy, and the management after its spontaneous rupture is not very well known. Case. In this paper, we present spontaneous rupture of the imperforate hymen in a 13-year-old adolescent girl with hematocolpometra just before a planned hymenotomy operation. The patient was managed conservatively with a satisfactory outcome. Conclusion. Hymenotomy may not be needed in cases with spontaneous rupture of the imperforate hymen if adequate opening for menstrual discharge is warranted.
Systematic differences between BNP immunoassays: comparison of methods using standard protocols and quality control materials.

BACKGROUND
Recent studies suggested that there are marked systematic differences among BNP immunoassays. In this study we compared the BNP data and clinical results obtained with different immunoassays, including a new method (ST-AIA-PACK, TOSOH Corporation).


METHODS
BNP was measured on plasma-EDTA samples of healthy subjects (HS, n=126) and patients with heart failure (HF, n=31 NYHA I, II; n=46 NYHA III, IV) using the ST-AIA-PACK and the Triage Biosite (Beckman Coulter) methods. Control samples distributed in the CardioOrmoCheck external quality assessment were also measured with TOSOH and the most used BNP immunoassays in Italy.


RESULTS
TOSOH method showed a good correlation (R=0.976; n=327) but a mean bias (-46.9%) compared to Triage Biosite. On the base of the results obtained in 10 samples of the CardioOrmoCheck study, TOSOH method showed a strict agreement with ADVIA Centaur, while it underestimated BNP in comparison with Triage (-52.5%) and ARCHITECT methods (-39.4%). The agreement of ST-AIA-PACK and Triage Biosite methods for classification of HF patients was tested using 100 ng/L of BNP; the positive agreement between methods was 65%, overall agreement was 73%.


CONCLUSIONS
Our results confirm that there are marked differences in measured values among commercial methods for BNP assay.
Acute treatment of generalized pustular psoriasis of von Zumbusch with single-dose infliximab.

REFERENCES 1. Fern andez-Guarino M, Aldanondo I, Gonz alez-Garc ıa C, Garrido P, Marquet A, P erez-Garc ıa B, et al. Dermatosis perforante por gefinitib. Actas Dermosifiliogr 2006;97:208-11. 2. Gilaberte Y, Coscojuela C, V azquez C, Rosell o R, Vera J. Perforating folliculitis associated with tumor necrosis factor alpha inhibitors administered for rheumatoid arthritis. Br J Dermatol 2007;156:368-71. 3. Vano-Galvan S, Moreno C, Medina J, P erez-Garc ıa B, Garc ıaL opez JL, Jaen P. Perforating dermatosis in a patient receiving bevacizumab. J Eur Acad Dermatol 2009;23:972-4. 4. Minami-Hori M, Ishida-Yamamoto A, Komatsu S, Iiduka H. Transient perforating folliculitis induced by sorafenib. J Dermatol 2010;37:833-4. 5. Wolber C, Udvardi A, Tatzreiter G, Schneeberger A, Volc-Platzer B. Perforating folliculitis, angioedema, hand-foot syndrome e multiple cutaneous side effects in a patient treated with sorafenib. J Dtsch Dermatol Ges 2009;7:449-52.
Extended-release niacin alters the metabolism of plasma apolipoprotein (Apo) A-I and ApoB-containing lipoproteins.

OBJECTIVE
Extended-release niacin effectively lowers plasma TG levels and raises plasma high-density lipoprotein (HDL) cholesterol levels, but the mechanisms responsible for these effects are unclear.


METHODS AND RESULTS
We examined the effects of extended-release niacin (2 g/d) and extended-release niacin (2 g/d) plus lovastatin (40 mg/d), relative to placebo, on the kinetics of apolipoprotein (apo) A-I and apoA-II in HDL, apoB-100 in TG-rich lipoproteins (TRL), intermediate-density lipoproteins (IDL) and low-density lipoproteins (LDL), and apoB-48 in TRL in 5 men with combined hyperlipidemia. Niacin significantly increased HDL cholesterol and apoA-I concentrations, associated with a significant increase in apoA-I production rate (PR) and no change in fractional catabolic rate (FCR). Plasma TRL apoB-100 levels were significantly lowered by niacin, accompanied by a trend toward an increase in FCR and no change in PR. Niacin treatment significantly increased TRL apoB-48 FCR but had no effect on apoB-48 PR. No effects of niacin on concentrations or kinetic parameters of IDL and LDL apoB-100 and HDL apoA-II were noted. The addition of lovastatin to niacin promoted a lowering in LDL apoB-100 attributable to increased LDL apoB-100 FCR.


CONCLUSIONS
Niacin treatment was associated with significant increases in HDL apoA-I concentrations and production, as well as enhanced clearance of TRL apoB-100 and apoB-48.
Melbourne desktop drawing

"The work investigates the visual interpretation of history. It contrasts history experienced by the individual as a subjective accumulation of events with other allegorical pictorial traditions linked to master narratives. Research motifs are the place of the subject and the role of witnessing. The work examines the reformulation of vertical pictorial space into a horizontal narrative ground. It examines how the art object integrates into the viewer's experience and considers how site and time construct public and private memory. The exhibition, Greg Creek: The Allegorical Imperative, placed in context and dialogue a range of painting and drawing works which illustrate his ongoing research into relations between political and personal histories, satire, narrative structure and visual languages. The project situates the artefacts of drawing process in an installation context that uses spatial extension and duration to engage the viewer's sense of private incidence in a public space. The work is related to the drawing installation projects of Raymond Pettibon (Contemporary Fine Arts, Berlin, 2008) and Kerry James Marshall (Documenta, kassell, 2007) where drawing styles from the cartoon, through incident to the finished render are employed. Commissioned by ACCA, Kay Campbell, Executive Director, said, '.. the second of our major commissions for the large hall.. the Melbourne Desktop drawing.. Greg's drawing joins Susan Norrie's Undertow as a major achievement made possible by ACCA under the artistic direction of Juliana Engberg.' The accompanying catalogue includes an interpretative essay by Juliana Engberg (2003), 'History, Heresey, Hearsay: Greg Creek's Melbourne Desktop Drawing, The Allegorical Imperative: Greg Creek's Slow Homecoming, ACCA, Melb. ISBN 0947220978. Published reviews include; Melbourne Herald-Sun 17/9/2003, Melbourne Herald-Sun 8/9/2003, Melbourne Age 20/8/2003, ABC Radio National 31/8/2003; Melbourne Age 23/8/2003, Financial Review 2/8/2003."
A New Version of Grain-128 with Authentication

A new version of the stream cipher Grain-128 is proposed. The new version, Grain-128a, is strengthened against all known attacks and observations on the original Grain-128, and has built-in support for authentication. The changes are modest, keeping the basic structure of Grain-128. This gives a high confidence in Grain-128a and allows for easy updating of existing implementations.
Threat evaluation of enemy air fighters via neural network-based Markov chain modeling

Threat evaluation (TE) is a process used to assess the threat values (TVs) of air-breathing threats (ABTs), such as air fighters, that are approaching defended assets (DAs). This study proposes an automatic method for conducting TE using radar information when ABTs infiltrate into territory where DAs are located. The method consists of target asset (TA) prediction and TE. We divide a friendly territory into discrete cells based on the effective range of anti-aircraft missiles. The TA prediction identifies the TA of each ABT by predicting the ABT’s movement through cells in the territory via a Markov chain, and the cell transition is modeled by neural networks. We calculate the TVs of the ABTs based on the TA prediction results. A simulation-based experiment revealed that the proposed method outperformed TE based on the closest point of approach or the radial speed vector methods. © 2016 Elsevier B.V. All rights reserved.
Memoirs of a Software Pioneer: Part I

In the first of this two-part series, these memoirs trace the software industry's beginnings back to the early struggles by software firms such as Applied Data Research as they tried to compete against IBM, the computer industry's Goliath. The author identifies the questions raised, from the antitrust suits and related issues, that led to IBM's unbundling in 1970.
Advanced learning algorithms for cross-language patent retrieval and classification

We study several machine learning algorithms for cross-lan7guage patent retrieval and classification. In comparison with most of other studies involving machine learning for cross-language information retrieval, which basically used learning techniques for monolingual sub-tasks, our learning algorithms exploit the bilingual training documents and learn a semantic representation from them. We study Japanese–English cross-language patent retrieval using Kernel Canonical Correlation Analysis (KCCA), a method of correlating linear relationships between two variables in kernel defined feature spaces. The results are quite encouraging and are significantly better than those obtained by other state of the art methods. We also investigate learning algorithms for cross-language document classification. The learning algorithm are based on KCCA and Support Vector Machines (SVM). In particular, we study two ways of combining the KCCA and SVM and found that one particular combination called SVM_2k achieved better results than other learning algorithms for either bilingual or monolingual test documents. 2006 Elsevier Ltd. All rights reserved.
Scanning electron microscopy of Antarctophthirus microchir (Phthiraptera: Anoplura: Echinophthiriidae): studying morphological adaptations to aquatic life.

The members of the Family Echinophthiriidae (Phthiraptera: Anoplura) are unique among insects because they infest hosts with an amphibious lifestyle. During their evolution they developed morphological traits that are reflected in unique features. The SEM is a helpful tool to analyze them. Knowing in detail the external structure of these lice is the first step to understand the whole process that derived from the co-adaptation of lice and pinnipeds to the marine environment. For the first time, we studied the external structure of all stages of an echinophthiriid louse. The results are discussed in the light of their evolutionary, functional, and ecological implications.
PHILOSOPHICAL SPECIALIZATION AND GENERAL PHILOSOPHY

La philosophie specialisee (analytique ou post-analytique) est compatible avec la philosophie generale et contribue a son developpement.
Imaging cerebral atrophy: normal ageing to Alzheimer's disease

CONTEXT
With ageing populations, the prevalence of dementia, especially Alzheimer's disease, is set to soar. Alzheimer's disease is associated with progressive cerebral atrophy, which can be seen on MRI with high resolution. Longitudinal MRI could track disease progression and detect neurodegenerative diseases earlier to allow prompt and specific treatment. Such use of MRI requires accurate understanding of how brain changes in normal ageing differ from those in dementia.


STARTING POINT
Recently, Henry Rusinek and colleagues, in a 6-year longitudinal MRI study of initially healthy elderly subjects, showed that an increased rate of atrophy in the medial temporal lobe predicted future cognitive decline with a specificity of 91% and sensitivity of 89% (Radiology 2003; 229: 691-96). WHERE NEXT? As understanding of neurodegenerative diseases increases, specific disease-modifying treatments might become available. Serial MRI could help to determine the efficacy of such treatments, which would be expected to slow the rate of atrophy towards that of normal ageing, and might also detect the onset of neurodegeneration. The amount and pattern of excess atrophy might help to predict the underlying pathological process, allowing specific therapies to be started. As the precision of imaging improves, the ability to distinguish healthy ageing from degenerative dementia should improve.
Student Segregation and Achievement Tracking in Year-Round Schools

Twenty-five percent of California’s elementary schoolchildren attend schools operating on nontraditional, staggered, overlapping attendance calendars collectively referred to as multitrack year-round education (MT-YRE). This case study reveals substantial differences in the characteristics of students and teachers across the four attendance tracks of eight MT-YRE schools in one large California school district. Analyses of Stanford Achievement Test data, controlling for student and teacher characteristics, reveal strong association of achievement with student demographic, programmatic, and teacher segregation within these MT-YRE schools. These findings suggest that MT-YRE readily (re)segregates students within schools and thereby inhibits access to equal educational opportunity relative to traditional and nontraditional single-track school calendars.
Parallel graph analytics

Data-centric abstractions and execution strategies are needed to exploit parallelism in large-scale graph analytics.