LLukas22/scidocs huggingface dataset:
DeepSpace: An Online Deep Learning Framework for Mobile Big Data to Understand Human Mobility Patterns

Abstract—In the recent years, the rapid spread of mobile device has create the vast amount of mobile data. However, some shallow-structure models such as support vector machine (SVM) have difficulty dealing with high dimensional data with the development of mobile network. In this paper, we analyze mobile data to predict human trajectories in order to understand human mobility pattern via a deep-structure model called “DeepSpace”. To the best of out knowledge, it is the first time that the deep learning approach is applied to predicting human trajectories. Furthermore, we develop the vanilla convolutional neural network (CNN) to be an online learning system, which can deal with the continuous mobile data stream. In general, “DeepSpace” consists of two different prediction models corresponding to different scales in space (the coarse prediction model and fine prediction models). This two models constitute a hierarchical structure, which enable the whole architecture to be run in parallel. Finally, we test our model based on the data usage detail records (UDRs) from the mobile cellular network in a city of southeastern China, instead of the call detail records (CDRs) which are widely used by others as usual. The experiment results show that “DeepSpace” is promising in human trajectories prediction.
SVD-based image splicing detection

Digital image forgery is becoming easier to perform because of the rapid development of various manipulation tools. Image splicing is one of the most common image forgery techniques. To detect the spliced images several methods proposed utilizing the statistical features of the digital images. In this paper, a new image splicing detection approach proposed based on singular value decomposition (SVD) feature extraction method applied in steganalysis. SVD-based features are merged with discrete cosine transform (DCT) for image splicing detection. Support vector machine is used to distinguish between authentic and spliced images. The results show a detection accuracy of 78.82% is achieved for the proposed method with only 50 dimensional feature vector. Furthermore the performance of SVD-based features needs more improvement in image splicing detection area of work.
Deep Learning Neural Network with Semi supervised Segmentation for Predicting Retinal and Cancer Cell Diseased Images.

In medical field, diagnosis of diseases competently carried out by using the image processing. So that to retrieve the relevant data from the amalgamation of resulting image is too difficult. Here the segmentation done by semi supervised learning then the result is tuned by using Deep Learning Neural Network. Higher tuning of results will leads to efficient detection of disease. The experiment done by using retinal image data sets in order to predict any disease affected or not. The aim of this paper is to keenly predict diseased image or not by the efficient tuning of image. Keywords—segmentation; semi supervised learning; Neural network; Deep learning neural network.
Effect of Rapid Solidification on Short-Range Order: A Magnetic Study.

Abstract : In this study of the effects of rapid solidification on short-range order and magnetic properties, major progress and significant results were achieved in four specific areas. 1) Short-range order in Co80NbxB20-x amorphous alloys was found to be similar at low x and dissimilar at large x to that of the equilibrium crystal structure. This key observation led to a broader model of magnetic properties in amorphous alloys. 2) Devitrification of two different metallic glasses led to technically and scientifically important discoveries related to the fine microstructures produces. 3) Theoretical cluster calculations of electronic structure significantly advanced our understanding of bonding and magnetism in amorphous alloys. Finally, 4), We found that magnetization reversal could be very well described by the soliton-like solutions to a realistic non-linear wave equation. This approach correctly describes the coupling of the wall motion to its own local strain field, a technically important effect.
Oral 5-aminolevulinic acid induced Photodynamic Diagnostic Ureterorenoscopy--does the blood pressure require monitoring?

BACKGROUND
Photodynamic Diagnosis has been proven to improve detection of superficial bladder cancer and improve visualisation of resection margins. The use of 5-aminolevulinic acid as the photosensitising agent has been associated with side effects, specifically hypotension. We aimed to evaluate the effect of oral 5-ALA on the blood pressure in a group of patient who underwent Photodynamic Diagnostic Ureterorenoscopy.


METHODS
We carried out an observational study on all patients who underwent PDD-Ureterorenoscopy with oral 5-ALA between July 2009 and September 2011. Pre-administration, hourly post-administration and hourly post-operative blood pressures were noted. Mean arterial blood pressure and the threshold for cerebral ischaemia were calculated as well.


RESULTS
The study includes thirty-eight procedures which involved twenty-four patients with a mean age of 74 (SD±16.95). Hypotension was defined as <80% of the systolic or diastolic baseline blood pressure. Twenty patients were hypotensive pre-operatively after the ingestion of 5-ALA while 21 patients were hypotensive post-operatively. Three patients crossed their MAP threshold pre-operatively and were symptomatic. Fast infusion of intravenous fluids improved their symptoms.


CONCLUSION
Hypotension is a common occurrence after the ingestion of 5-ALA. Patients undergoing PDD Ureterorenoscopy should have their blood pressure monitored closely after the ingestion of 5-ALA.
Randomized phase 2 study of obinutuzumab monotherapy in symptomatic, previously untreated chronic lymphocytic leukemia.

Obinutuzumab is a glycoengineered, type 2 anti-CD20 humanized antibody with single-agent activity in relapsed chronic lymphocytic leukemia (CLL). With other CD20 antibodies, a dose-response relationship has been shown. We therefore performed a randomized phase 2 study in symptomatic, untreated CLL patients to evaluate if an obinutuzumab dose response exists. Obinutuzumab was given at a dose of 1000 mg (100 mg IV day 1, 900 mg day 2, 1000 mg day 8 and day 15 of cycle 1; 1000 mg day 1 of cycles 2-8) or 2000 mg (100 mg IV day 1, 900 mg day 2, 1000 mg day 3, 2000 mg day 8 and day 15 of cycle 1; 2000 mg day 1 of cycles 2-8). The primary end point was overall response rate (ORR). Eighty patients were enrolled with similar demographics: median age 67 years, 41% high-risk Rai disease, and 10% del(17p)(13.1). ORR (67% vs 49%, P = .08) and complete response (CR) or CR with incomplete cytopenia response (20% vs 5%) favored 2000 mg obinutuzumab. Overall, therapy was well tolerated, and infusion events were manageable. This study demonstrates significant efficacy of obinutuzumab monotherapy, for 1000 mg as well as for 2000 mg, in untreated CLL patients with acceptable toxicity. Although exploratory, a dose-response relationship may exist, but its relevance to improving progression-free survival is uncertain and will require further follow-up. This trial was registered at www.clinicaltrials.gov as #NCT01414205.
Finding shell company accounts using anomaly detection

Money laundering refers to activities pertaining to hiding the true income, evading taxes, or converting illegally earned money for normal use. These activities are often performed through shell companies that masquerade as real companies but where actual the purpose is to launder money. Shell companies are used in all the three phases of money laundering, namely, placement, layering, and integration, often simultaneously. In this paper, we aim to identify shell companies. We propose to use only bank transactions since that is easily available. In particular, we look at all incoming and outgoing transactions from a particular bank account along with its various attributes, and use anomaly detection techniques to identify the accounts that pertain to shell companies. Our aim is to create an initial list of potential shell company candidates which can be investigated by financial experts later. Due to lack of real data, we propose a banking transactions simulator (BTS) to simulate both honest as well as shell company transactions by studying a host of actual real-world fraud cases. We apply anomaly detection algorithms to detect candidate shell companies. Results indicate that we are able to identify the shell companies with a high degree of precision and recall.1
Self-Tracking, Social Media and Personal Health Records for Patient Empowered Self-Care. Contribution of the IMIA Social Media Working Group.

OBJECTIVES
This paper explores the range of self-tracking devices and social media platforms used by the self-tracking community, and examines the implications of widespread adoption of these tools for scientific progress in health informatics.


METHODS
A literature review was performed to investigate the use of social media and self-tracking technologies in the health sector. An environmental scan identified a range of products and services which were used to exemplify three levels of self-tracking: self-experimentation, social sharing of data and patient controlled electronic health records.


RESULTS
There appears to be an increase in the use of self-tracking tools, particularly in the health and fitness sector, but also used in the management of chronic diseases. Evidence of efficacy and effectiveness is limited to date, primarily due to the health and fitness focus of current solutions as opposed to their use in disease management.


CONCLUSIONS
Several key technologies are converging to produce a trend of increased personal health surveillance and monitoring, social connectedness and sharing, and integration of regional and national health information systems. These trends are enabling new applications of scientific techniques, from personal experimentation to e-epidemiology, as data gathered by individuals are aggregated and shared across increasingly connected healthcare networks. These trends also raise significant new ethical and scientific issues that will need to be addressed, both by health informatics researchers and the communities of self-trackers themselves.
Diagnostic utility of endocervical curettage in women undergoing colposcopy for equivocal or low-grade cytologic abnormalities.

OBJECTIVE
To estimate the diagnostic yield of endocervical curettage (ECC) when performed as part of a colposcopic procedure in the multicenter ASCUS-LSIL Triage Study (ALTS), a randomized trial of management strategies for women with equivocal or mildly abnormal cytology.


METHODS
A total of 1,119 women in ALTS had colposcopic examinations that included an ECC performed at the discretion of the colposcopist. We compared the results of ECC and concurrent cervical colposcopic evaluation, with or without biopsy, in prediction of final histopathologic diagnosis. This was defined as the worst histopathologic result from that colposcopy or any subsequent procedure during 2 years of follow-up.


RESULTS
Overall, 3.7% of ECCs yielded a diagnostic abnormality of cervical intraepithelial neoplasia (CIN) 2+ compared with 21.7% of colposcopically directed biopsies. In women ultimately found to have CIN 2+ in the trial, the overall sensitivity of colposcopically directed biopsy was 72.5%, compared with 12.2% for ECC. In women under 40, the marginal contribution of ECC, independently of biopsy, was only 2.2%. By contrast, among women 40 and older, the sensitivity of biopsy dropped while the sensitivity of ECC improved, resulting in 13.0% increased detection with ECC, independently of biopsy. However, in women 40 and older, the combined sensitivity of ECC and biopsy was only 47.8% for a single colposcopy procedure.


CONCLUSION
As an ancillary diagnostic technique to colposcopically directed biopsy, ECC is of questionable value in younger women. However, in women aged 40 and older, the sensitivity of colposcopic biopsy decreased and the sensitivity of ECC increased. Thus, ECC may be useful in older women undergoing colposcopy for equivocal or mildly abnormal cytology.
Anatomical correlates of ocular motor deficits in cerebellar lesions.

Humans are able to stabilize the images of moving targets on the retina by means of smooth pursuit eye movements. After the pontine level, all smooth pursuit pathways pass through the cerebellum. Previous animal studies gave evidence that two specific lesion sites within the cerebellum cause smooth pursuit disorders: those of the flocculus/paraflocculus and the vermis including lobule VI, VII, the uvula and the deep cerebellar nuclei. To date, there have been only a few lesion studies in patients with smooth pursuit disorders that do not allow direct comparison with a control group. In the present study, new lesion mapping techniques determined which cerebellar structures were involved in patients with deficits of smooth pursuit eye movements, slow phase of optokinetic nystagmus (OKN) and fixation suppression of vestibulo-ocular reflex, i.e. in eye movements that are considered to belong to the smooth pursuit system. The aim was to elucidate whether there is an anatomical and clinical link between these different eye movement disorders. Seventeen patients with acute, mainly unilateral cerebellar infarctions and an intact gain of the smooth pursuit system were compared with 11 patients with cerebellar lesions and deficient gain of sinusoidal smooth pursuit eye movements by means of lesion-mapping imaging. In addition, lesion analyses were conducted in subgroups with impaired fixation suppression of vestibulo-ocular reflex and deficient gain of the slow phase of the OKN. The uvula and partly the vermal pyramid were found to be the structures commonly damaged in patients with deficient gain of the horizontal sinusoidal smooth pursuit eye movement, of the slow phase of the OKN and impaired fixation suppression of vestibulo-ocular reflex; and were less involved in patients with intact smooth pursuit system. The present data give evidence for an anatomical link between sinusoidal smooth pursuit eye movements, fixation suppression of vestibulo-ocular reflex and the slow phases of OKN implying that the uvula and the vermal pyramid are important structures for generating slow phases within the smooth pursuit network in humans.
Improving Mechanical Characteristics of Inverter-induction Motor Drive System

An inverter-three-phase squirrel-cage induction mot or drive system with improved mechanical characteristics is presented. The propos ed system provides mechanical characteristics with constant maximum torque or increased maximum torque and reduced slip speed at frequencies below the nominal frequency. The control algorithm is bas ed on the constant volts per hertz principle using two improvement techniques: keeping maximum torque constant or keeping magnetic flux constant. Performance analysis of the system under different operation conditions was provided. For this purpose, a standard state-space model of three-phas e squirrel-cage induction motor, with respect to a synchronously rotating d-q reference frame was deri ved. The correctness and validity of the derived model of induction motor was verified. The inverter was considered as a static linear element and modeled through its input-output equation based on the modulation index. Three types of controllers were modeled, simulated and experimentally tested. The results show that both suggested control methods improve the system performance. The slip sp eed has been decreased and the starting torque and maximum torque have been increased. Controller with constant maximum torque can be used in drive systems working with constant load, while con tr ller with constant flux can be used in drive systems working with constant power.
A pilot randomized controlled trial comparing CABG surgery performed with total arterial grafts or without

OBJECTIVE
To date only a few randomized controlled studies have compared grafting strategies in patients with multi-vessel coronary disease. This study represents a pilot RCT designed to test the feasibility of a trial comparing conventional CABG performed with a LIMA-LAD plus saphenous vein grafts (LIMA+SVG) and CABG performed with total arterial grafting (TAG).


METHODS
Consenting patients undergoing non-redo isolated CABG surgery at a single institution were randomized to TAG or LIMA+SVG groups. Exclusion criteria included prior CABG, emergent procedure, concomitant procedure, varicose veins and renal dysfunction. The primary endpoints were: enrolment >20% and completion of CT coronary angiography at 6 months >80%. Statistical investigation was performed on an intention to treat analysis.


RESULTS
Of 421 eligible patients, 60 were enrolled and 2 withdrew (n = 30 in TAG, n = 28 LIMA+SVG) for 14% enrolment rate. Patient characteristics were similar in each group. No patients died in hospital and adverse events such as MI, stroke and deep sternal wound infection were not significantly different between groups. Clinical follow-up was complete in 100% of patients, with 44/58 (76%) undergoing CT coronary angio at 6 months. Graft occlusion occurred in 2 patients in each group for patency rates of 89% (TAG) and 91% (LIMA+SVG).


CONCLUSIONS
We provide evidence that an RCT comparing grafting strategy is possible but also show that achieving recruitment or follow-up CT may be difficult. Given the excellent patency results and little difference between groups, our findings suggest that the sample size required may make it infeasible to compare graft patency at 6 months as a study end-point.


TRIAL REGISTRATION
Randomized Controlled Trial number: ISRCTN80270323 . Few RCT's exist comparing conventional CABG performed with a LIMA-LAD plus saphenous vein grafts (LIMA+SVG) compared to CABG performed with total arterial grafting (TAG). This study is a pilot RCT designed to test the feasibility of such a trial and identify pitfalls.
Depression and Internet addiction in adolescents.

BACKGROUND
The aim of the study was to evaluate the relationship between depression and Internet addiction among adolescents.


SAMPLING AND METHOD
A total of 452 Korean adolescents were studied. First, they were evaluated for their severity of Internet addiction with consideration of their behavioral characteristics and their primary purpose for computer use. Second, we investigated correlations between Internet addiction and depression, alcohol dependence and obsessive-compulsive symptoms. Third, the relationship between Internet addiction and biogenetic temperament as assessed by the Temperament and Character Inventory was evaluated.


RESULTS
Internet addiction was significantly associated with depressive symptoms and obsessive-compulsive symptoms. Regarding biogenetic temperament and character patterns, high harm avoidance, low self-directedness, low cooperativeness and high self-transcendence were correlated with Internet addiction. In multivariate analysis, among clinical symptoms depression was most closely related to Internet addiction, even after controlling for differences in biogenetic temperament.


CONCLUSIONS
This study reveals a significant association between Internet addiction and depressive symptoms in adolescents. This association is supported by temperament profiles of the Internet addiction group. The data suggest the necessity of the evaluation of the potential underlying depression in the treatment of Internet-addicted adolescents.
OR FORUM - Little's Law as Viewed on Its 50th Anniversary

Fifty years ago, the author published a paper in Operations Research with the title, “A proof for the queuing formula: L = W ” [Little, J. D. C. 1961. A proof for the queuing formula: L = W . Oper. Res. 9(3) 383–387]. Over the years, L = W has become widely known as “Little’s Law.” Basically, it is a theorem in queuing theory. It has become well known because of its theoretical and practical importance. We report key developments in both areas with the emphasis on practice. In the latter, we collect new material and search for insights on the use of Little’s Law within the fields of operations management and computer architecture.
Class II malocclusion treated with miniscrew anchorage: comparison with traditional orthodontic mechanics outcomes.

INTRODUCTION
Anchorage control in patients with severe skeletal Class II malocclusion is a difficult problem in orthodontic treatment. In adults, treatment often requires premolar extractions and maximum anchorage. Recently, incisor retraction with miniscrew anchorage has become a new strategy for treating skeletal Class II patients.


METHODS
In this study, we compared treatment outcomes of patients with severe skeletal Class II malocclusion treated using miniscrew anchorage (n = 11) or traditional orthodontic mechanics of headgear and transpalatal arch (n = 11). Pretreatment and posttreatment lateral cephalograms were analyzed.


RESULTS
Both treatment methods, miniscrew anchorage or headgear, achieved acceptable results as indicated by the reduction of overjet and the improvement of facial profile. However, incisor retraction with miniscrew anchorage did not require patient cooperation to reinforce the anchorage and provided more significant improvement of the facial profile than traditional anchorage mechanics (headgear combined with transpalatal arch).


CONCLUSIONS
Orthodontic treatment with miniscrew anchorage is simpler and more useful than that with traditional anchorage mechanics for patients with Class II malocclusion.
An evaluation of state switching methods for indirect touch systems

Indirect touch systems combine a horizontal touch input surface with a vertical display for output. While this division is ergonomically superior to simple direct-touch displays for many tasks, users are no longer looking at their hands when touching. This requires the system to support an intermediate \'1ctracking\'1d state that lets users aim at objects without triggering a selection, similar to the hover state in mouse-based UIs. We present an empirical analysis of several interaction techniques for indirect touch systems to switch to this intermediate state, and derive design recommendations for incorporating it into such systems.
Cognitive Results of CANTAB Tests and Their Change Due to the First Dose of Donepezil May Predict Treatment Efficacy in Alzheimer Disease

BACKGROUND Ability to predict the efficacy of treatment in Alzheimer disease (AD) may be very useful in clinical practice. Cognitive predictors should be investigated alongside with the demographic, genetic, and other predictors of treatment efficacy. The aim of this study was to establish whether the baseline measures of CANTAB tests and their changes due to the first donepezil dose are able to predict the efficacy of treatment after 4 months of therapy. We also compared the predictive value of cognitive, clinical, and demographic predictors of treatment efficacy in AD. MATERIAL AND METHODS Seventy-two AD patients (62 treatment-naïve and 10 donepezil-treated) and 30 controls were enrolled in this prospective, randomized, rater-blinded, follow-up study. Treatment-naïve AD patients were randomized to 2 groups to take the first donepezil dose after the first or second CANTAB testing, separated by 4 hours. Follow-up Test 3 was performed 4 months after the initial assessment. RESULTS The groups were similar in age, education, gender, Hachinski index, and depression. General Regression Models (GRM) have shown that cognitive changes after the first dose of donepezil in PAL (t-values for regression coefficients from 3.43 to 6.44), PRMd (t=4.33), SWM (t=5.85) test scores, and baseline results of PAL (t=2.57-2.86), PRM (t=3.08), and CRT (t=3.42) tests were significant predictors of long-term donepezil efficacy in AD (p<0.05). CONCLUSIONS The cognitive changes produced by the first donepezil dose in CANTAB PAL, PRM, and SWM test measures are able to predict the long-term efficacy of donepezil in AD. Baseline PAL, PRM, and CRT test results were significant predictors.