LLukas22/scidocs huggingface dataset:
On the Computational Efficiency of Training Neural Networks

Neural Networks are formally hard to train. How can we circumvent hardness results? • Over specified networks: While over specification seems to speedup training , formally hardness results are valid in the improper model. • Changing the activation function: While changing the activation function from sigmoid to ReLu has lead to faster convergence of SGD methods, formally these networks are still hard.
Antimicrobial and Cytotoxic Assessment of Marine Cyanobacteria - Synechocystis and Synechococcus

Aqueous extracts and organic solvent extracts of isolated marine cyanobacteria strains were tested for antimicrobial activity against a fungus, Gram-positive and Gram-negative bacteria and for cytotoxic activity against primary rat hepatocytes and HL-60 cells. Antimicrobial activity was based on the agar diffusion assay. Cytotoxic activity was measured by apoptotic cell death scored by cell surface evaluation and nuclear morphology. A high percentage of apoptotic cells were observed for HL-60 cells when treated with cyanobacterial organic extracts. Slight apoptotic effects were observed in primary rat hepatocytes when exposed to aqueous cyanobacterial extracts. Nine cyanobacteria strains were found to have antibiotic activity against two Gram-positive bacteria, Clavibacter michiganensis subsp. insidiosum and Cellulomonas uda. No inhibitory effects were found against the fungus Candida albicans and Gram-negative bacteria. Marine Synechocystis and Synechococcus extracts induce apoptosis in eukaryotic cells and cause inhibition of Gram-positive bacteria. The different activity in different extracts suggests different compounds with different polarities.
Fuzzy optimization for supply chain planning under supply, demand and process uncertainties

In today’s global marketplace, individual firms do not compete as independent entities rather as an integral part of a supply chain. This paper proposes a fuzzy mathematical programming model for supply chain planning which considers supply, demand and process uncertainties. The model has been formulated as a fuzzy mixed-integer linear programming model where data are ill-known andmodelled by triangular fuzzy numbers. The fuzzy model provides the decision maker with alternative decision plans for different degrees of satisfaction. This proposal is tested by using data from a real automobile supply chain. © 2009 Elsevier B.V. All rights reserved.
High bandwidth fast steering mirror

A high bandwidth, gimbaled, fast steering mirror (FSM) assembly has been designed and tested at the Lockheed Martin Space Systems Company (LMSSC) Advanced Technology Center (ATC). The design requirements were to gimbal a 5 cm diameter mirror about its reflective surface, and provide 1 KHz tip/tilt/piston control while maintaining λ/900 flatness of the mirror. The simple, yet very compact and rugged device also has manual tip/tilt/piston alignment capability. The off-the-shelf Piezo translators (PZT) actuators enable reliable and repeatable closed loop control. The adopted solution achieves a good mass balance and gimbaled motion about the center of the mirror front surface. Special care was taken to insure the best positioning means with the mounted mirror assembly held kinematically in place. The manual adjusters have very good resolution, with the capability to be locked in place. All solutions were thoroughly modeled and analyzed. This paper covers the design, analysis, fabrication, assembly, and testing of this device. The FSM was designed for ground test only.
e-Monitoring of Asthma Therapy to Improve Compliance in children using a real-time medication monitoring system (RTMM): the e-MATIC study protocol

BACKGROUND
Many children with asthma do not have sufficient asthma control, which leads to increased healthcare costs and productivity loss of parents. One of the causative factors are adherence problems. Effective interventions improving medication adherence may therefore improve asthma control and reduce costs. A promising solution is sending real time text-messages via the mobile phone network, when a medicine is about to be forgotten. As the effect of real time text-messages in children with asthma is unknown, the primary aim of this study is to determine the effect of a Real Time Medication Monitoring system (RTMM) with text-messages on adherence to inhaled corticosteroids (ICS). The secondary objective is to study the effects of RTMM on asthma control, quality of life and cost-effectiveness of treatment.


METHODS
A multicenter, randomized controlled trial involving 220 children (4-11 years) using ICS for asthma. All children receive an RTMM-device for one year, which registers time and date of ICS doses. Children in the intervention group also receive tailored text-messages, sent only when a dose is at risk of omission. Primary outcome measure is the proportion of ICS dosages taken within the individually predefined time-interval. Secondary outcome measures include asthma control (monthly Asthma Control Tests), asthma exacerbations, healthcare use (collected from hospital records, patient reports and pharmacy record data), and disease-specific quality of life (PAQLQ questionnaire). Parental and children's acceptance of RTMM is evaluated with online focus groups and patient questionnaires. An economic evaluation is performed adopting a societal perspective, including relevant healthcare costs and parental productivity loss. Furthermore, a decision-analytic model is developed in which different levels of adherence are associated with clinical and financial outcomes. Also, sensitivity analyses are carried out on different price levels for RTMM.


DISCUSSION
If RTMM with tailored text-message reminders proves to be effective, this technique can be used in daily practice, which would support children with suboptimal adherence in their asthma (self)management and in achieving better asthma control and better quality of life.


TRIAL REGISTRATION
Netherlands Trial Register NTR2583.
Surface plasmon resonance sensors for detection of chemical and biological species.

5.1. Detection Formats 475 5.2. Food Quality and Safety Analysis 477 5.2.1. Pathogens 477 5.2.2. Toxins 479 5.2.3. Veterinary Drugs 479 5.2.4. Vitamins 480 5.2.5. Hormones 480 5.2.6. Diagnostic Antibodies 480 5.2.7. Allergens 481 5.2.8. Proteins 481 5.2.9. Chemical Contaminants 481 5.3. Medical Diagnostics 481 5.3.1. Cancer Markers 481 5.3.2. Antibodies against Viral Pathogens 482 5.3.3. Drugs and Drug-Induced Antibodies 483 5.3.4. Hormones 483 5.3.5. Allergy Markers 483 5.3.6. Heart Attack Markers 484 5.3.7. Other Molecular Biomarkers 484 5.4. Environmental Monitoring 484 5.4.1. Pesticides 484 5.4.2. 2,4,6-Trinitrotoluene (TNT) 485 5.4.3. Aromatic Hydrocarbons 485 5.4.4. Heavy Metals 485 5.4.5. Phenols 485 5.4.6. Polychlorinated Biphenyls 487 5.4.7. Dioxins 487 5.5. Summary 488 6. Conclusions 489 7. Abbreviations 489 8. Acknowledgment 489 9. References 489
Little evidence of association between severity of trigonocephaly and cognitive development in infants with single-suture metopic synostosis.

OBJECTIVES
To measure severity of trigonocephaly among infants with single-suture metopic craniosynostosis by using a novel shape descriptor, the trigonocephaly severity index (TSI), and to evaluate whether degree of trigonocephaly correlates with their neurodevelopmental test scores.


METHODS
We conducted a multicenter cross-sectional and longitudinal study, identifying and recruiting 65 infants with metopic synostosis before their corrective surgery. We obtained computed tomography images for 49 infants and measured the presurgical TSI, a 3-dimensional outline-based cranial shape descriptor. We evaluated neurodevelopment by administering the Bayley Scales of Infant Development, Second Edition, and the Preschool Language Scale, Third Edition, before surgery and at 18 and 36 months of age. We fit linear regression models to estimate associations between test scores and TSI values adjusted for age at testing and race/ethnicity. We fit logistic regression models to estimate whether the odds of developmental delay were increased among children with more severe trigonocephaly.


RESULTS
We observed little adjusted association between neurodevelopmental test scores and TSI values, and no associations that persisted at 3 years. Trigonocephaly was less severe among children referred at older ages.


CONCLUSION
We observed little evidence of an association between the severity of trigonocephaly among metopic synostosis patients and their neurodevelopmental test scores. Detecting such a relationship with precision may require larger sample sizes or alternative phenotypic quantifiers. Until studies are conducted to explore these possibilities, it appears that although associated with the presence of metopic synostosis, the risk of developmental delays in young children is unrelated to further variation in trigonocephalic shape.
Low-Swing Differential Conditional Capturing Flip-Flop for LC Resonant Clock Distribution Networks

In this paper we introduce a new flip-flop for use in a low- swing LC resonant clocking scheme. The proposed low-swing differential conditional capturing flip-flop (LS-DCCFF) operates with a low-swing sinusoidal clock through the utilization of reduced swing inverters at the clock port. The functionality of the proposed flip-flop was verified at extreme corners through simulations with parasitics extracted from layout. The LS-DCCFF enables 6.5% reduction in power compared to the full- swing flip-flop with 19% area overhead. In addition, a frequency dependent delay associated with driving pulsed flip-flops with a low-swing sinusoidal clock has been characterized. The LS-DCCFF has 870 ps longer data to output delay as compared to the full-swing flip-flop at the same setup time for a 100 MHz sinusoidal clock. The functionality of the proposed flip-flop was tested and verified by using the LS-DCCFF in a dual-mode multiply and accumulate (MAC) unit fabricated in TSMC 90-nm CMOS technology. Low-swing resonant clocking achieved around 5.8% reduction in total power with 5.7% area overhead for the MAC.
Citizenship, nationality, and ethnicity : reconciling competing identities

Part I: The Conceptual Kit: The Search for Clarity: . 1. Introducing the Argument. 2. Rethinking Citizenship, Nationality and Ethnicity. 3. Avoiding Conflations and Subsumptions. 4. Race and Religion: Untenable Factors in Nation Formation. Part II: The Empirical Process: The Trajectory of Ethnification: . 5. Colonialism and European Expansion. 6. Proletarian Internationalism and the Socialist State. 7. The Nation--State and Project Homogenization. 8. Immigration and the Chauvinism of Prosperity. Part III: Towards a Rapproachment: Concepts and Reality: . 9. Reconceptualizing Nation and Nationality: The Cruciality of Territory and Language. 10. Class, Nation, Ethnie and Race: Interlinkages. 11. Reconciling Nationality and Ethnicity: The Role of Citizenship. Notes. References. Index.
The anti-inflammatory activity of licorice, a widely used Chinese herb.

CONTEXT
Increasing incidence and impact of inflammatory diseases have encouraged the search of new pharmacological strategies to face them. Licorice has been used to treat inflammatory diseases since ancient times in China.


OBJECTIVE
To summarize the current knowledge on anti-inflammatory properties and mechanisms of compounds isolated from licorice, to introduce the traditional use, modern clinical trials and officially approved drugs, to evaluate the safety and to obtain new insights for further research of licorice.


METHODS
PubMed, Web of Science, Science Direct and ResearchGate were information sources for the search terms 'licorice', 'licorice metabolites', 'anti-inflammatory', 'triterpenoids', 'flavonoids' and their combinations, mainly from year 2010 to 2016 without language restriction. Studies were selected from Science Citation Index journals, in vitro studies with Jadad score less than 2 points and in vivo and clinical studies with experimental flaws were excluded.


RESULTS
Two hundred and ninety-five papers were searched and 93 papers were reviewed. Licorice extract, 3 triterpenes and 13 flavonoids exhibit evident anti-inflammatory properties mainly by decreasing TNF, MMPs, PGE2 and free radicals, which also explained its traditional applications in stimulating digestive system functions, eliminating phlegm, relieving coughing, nourishing qi and alleviating pain in TCM. Five hundred and fifty-four drugs containing licorice have been approved by CFDA. The side effect may due to the cortical hormone like action.


CONCLUSION
Licorice and its natural compounds have demonstrated anti-inflammatory activities. More pharmacokinetic studies using different models with different dosages should be carried out, and the maximum tolerated dose is also critical for clinical use of licorice extract and purified compounds.
Single centre 20 year survey of antiepileptic drug-induced hypersensitivity reactions.

BACKGROUND
Epilepsy is a chronic neurological disease which affects about 1% of the human population. There are 50 million patients in the world suffering from this disease and 2 million new cases per year are observed. The necessary treatment with antiepileptic drugs (AEDs) increases the risk of adverse reactions. In case of 15% of people receiving AEDs, cutaneous reactions, like maculopapular or erythematous pruritic rash, may appear within four weeks of initiating therapy with AEDs.


METHODS
This study involved 300 epileptic patients in the period between September 1989 and September 2009. A cutaneous adverse reaction was defined as a diffuse rash, which had no other obvious reason than a drug effect, and resulted in contacting a physician.


RESULTS
Among 300 epileptic patients of Neurological Practice in Kielce (132 males and 168 females), a skin reaction to at least one AED was found in 30 patients. As much as 95% of the reactions occurred during therapies with carbamazepine, phenytoin, lamotrigine or oxcarbazepine. One of the patients developed Stevens-Johnson syndrome.


CONCLUSION
Some hypersensitivity problems of epileptic patients were obviously related to antiepileptic treatment. Among AEDs, gabapentin, topiramate, levetiracetam, vigabatrin, and phenobarbital were not associated with skin lesions, although the number of patients in the case of the latter was small.
Hamming Clustering: A New Approach to Rule Extraction

A new algorithm, called Hamming Clustering (HC), is proposed to extract a set of rules underlying a given classification problem. It is able to reconstruct the and-or expression associated with any Boolean function from a training set of
Modeling and simulation of the power transformer faults and related protective relay behavior

The modeling of power transformer faults and its application to performance evaluation of a commercial digital power transformer relay are the objective of this study. A new method to build an EMTP/ATP power transformer model is proposed in this paper. Detailed modeling of the transformer relay is also discussed. The transient waveforms generated by ATP under different operating conditions are utilized to evaluate the performance of the transformer relay. The computer simulation results presented in this paper are consistent with the laboratory test result obtained using an analog power system model.
Metric Learning

Similarity between objects plays an important role in both human cognitive processes and artificial systems for recognition and categorization. How to appropriately measure such similarities for a given task is crucial to the performance of many machine learning, pattern recognition and data mining methods. is book is devoted to metric learning, a set of techniques to automatically learn similarity and distance functions from data that has attracted a lot of interest in machine learning and related fields in the past ten years. In this book, we provide a thorough review of the metric learning literature that covers algorithms, theory and applications for both numerical and structured data. We first introduce relevant definitions and classic metric functions, as well as examples of their use in machine learning and data mining. We then review a wide range of metric learning algorithms, starting with the simple setting of linear distance and similarity learning. We show how one may scale-up these methods to very large amounts of training data. To go beyond the linear case, we discuss methods that learn nonlinear metrics or multiple linear metrics throughout the feature space, and review methods for more complex settings such as multi-task and semi-supervised learning. Although most of the existing work has focused on numerical data, we cover the literature on metric learning for structured data like strings, trees, graphs and time series. In the more technical part of the book, we present some recent statistical frameworks for analyzing the generalization performance in metric learning and derive results for some of the algorithms presented earlier. Finally, we illustrate the relevance of metric learning in real-world problems through a series of successful applications to computer vision, bioinformatics and information retrieval.
Transdiaphragmatic pressure and neural respiratory drive measured during inspiratory muscle training in stable patients with chronic obstructive pulmonary disease

PURPOSE
Inspiratory muscle training (IMT) is a rehabilitation therapy for stable patients with COPD. However, its therapeutic effect remains undefined due to the unclear nature of diaphragmatic mobilization during IMT. Diaphragmatic mobilization, represented by transdiaphragmatic pressure (Pdi), and neural respiratory drive, expressed as the corrected root mean square (RMS) of the diaphragmatic electromyogram (EMGdi), both provide vital information to select the proper IMT device and loads in COPD, therefore contributing to the curative effect of IMT. Pdi and RMS of EMGdi (RMSdi%) were measured and compared during inspiratory resistive training and threshold load training in stable patients with COPD.


PATIENTS AND METHODS
Pdi and neural respiratory drive were measured continuously during inspiratory resistive training and threshold load training in 12 stable patients with COPD (forced expiratory volume in 1 s ± SD was 26.1%±10.2% predicted).


RESULTS
Pdi was significantly higher during high-intensity threshold load training (91.46±17.24 cmH2O) than during inspiratory resistive training (27.24±6.13 cmH2O) in stable patients with COPD, with P<0.01 for each. Significant difference was also found in RMSdi% between high-intensity threshold load training and inspiratory resistive training (69.98%±16.78% vs 17.26%±14.65%, P<0.01).


CONCLUSION
We concluded that threshold load training shows greater mobilization of Pdi and neural respiratory drive than inspiratory resistive training in stable patients with COPD.
Patterns and correlates of physical activity: a cross-sectional study in urban Chinese women

BACKGROUND
Inactivity is a modifiable risk factor for many diseases. Rapid economic development in China has been associated with changes in lifestyle, including physical activity. The purpose of this study was to investigate the patterns and correlates of physical activity in middle-aged and elderly women from urban Shanghai.


METHODS
Study population consisted of 74,942 Chinese women, 40-70 years of age, participating in the baseline survey of the Shanghai Women's Health Study (1997-2000), an ongoing population-based cohort study. A validated, interviewer-administered physical activity questionnaire was used to collect information about several physical activity domains (exercise/sports, walking and cycling for transportation, housework). Correlations between physical activity domains were evaluated by Spearman rank-correlation coefficients. Associations between physical activity and socio-demographic and lifestyle factors were evaluated by odds ratios derived from logistic regression.


RESULTS
While more than a third of study participants engaged in regular exercise, this form of activity contributed only about 10% to daily non-occupational energy expenditure. About two-thirds of women met current recommendations for lifestyle activity. Age was positively associated with participation in exercise/sports and housework. Dietary energy intake was positively associated with all physical activity domains. High socioeconomic status, unemployment (including retirement), history of chronic disease, small household, non-smoking status, alcohol and tea consumption, and ginseng intake were all positively associated with exercise participation. High socioeconomic status and small household were inversely associated with non-exercise activities.


CONCLUSION
This study demonstrates that physical activity domains other than sports and exercise are important contributors to total energy expenditure in women. Correlates of physical activity are domain-specific. These findings provide important information for research on the health benefits of physical activity and have public health implications for designing interventions to promote participation in physical activity.
Understanding Search-Engine Optimization

Because users rarely click on links beyond the first search results page, boosting search-engine ranking has become essential to business success. With a deeper knowledge of search-engine optimization best practices, organizations can avoid unethical practices and effectively monitor strategies approved by popular search engines.
Health Facility Utilisation Changes during the Introduction of Community Case Management of Malaria in South Western Uganda: An Interrupted Time Series Approach

BACKGROUND
Malaria endemic countries have scaled-up community health worker (CHW) interventions, to diagnose and treat malaria in communities with limited access to public health systems. The evaluations of these programmes have centred on CHW's compliance to guidelines, but the broader changes at public health centres including utilisation and diagnoses made, has received limited attention.


METHODS
This analysis was conducted during a CHW-intervention for malaria in Rukungiri District, Western Uganda. Outpatient department (OPD) visit data were collected for children under-5 attending three health centres one year before the CHW-intervention started (pre-intervention period) and for 20 months during the intervention (intervention-period). An interrupted time series analysis with segmented regression models was used to compare the trends in malaria, non-malaria and overall OPD visits during the pre-intervention and intervention-period.


RESULTS
The introduction of a CHW-intervention suggested the frequency of diagnoses of diarrhoeal diseases, pneumonia and helminths increased, whilst the frequency of malaria diagnoses declined at health centres. In May 2010 when the intervention began, overall health centre utilisation decreased by 63% compared to the pre-intervention period and the health centres saw 32 fewer overall visits per month compared to the pre-intervention period (p<0.001). Malaria visits also declined shortly after the intervention began and there were 27 fewer visits per month during the intervention-period compared with the pre-intervention period (p<0.05). The declines in overall and malaria visits were sustained for the entire intervention-period. In contrast, there were no observable changes in trends of non-malarial visits between the pre-intervention and intervention-period.


CONCLUSIONS
This analysis suggests introducing a CHW-intervention can reduce the number of child malaria visits and change the profile of cases presenting at health centres. The reduction in workload of health workers may allow them to spend more time with patients or undertake additional curative or preventative roles.