LLukas22/scidocs huggingface dataset:
Annotation in the wild: benefits of linking paper to digital media

This work presents the design of ALT, a prototype system that supports learning activities on the move by enabling users to annotate and sketch on paper in collaboration with a remote peer. Initial observations of learners interacting with ALT during an informal learning event show that paper annotation combined with synchronous communication technology shifts learners to use annotation as a basis for discussion and more personal interpretation of the information available.
Repeatability of diagnostic features and scoring systems for hepatocellular carcinoma by using MR imaging.

PURPOSE
To determine for expert and novice radiologists repeatability of major diagnostic features and scoring systems (ie, Liver Imaging Reporting and Data System [LI-RADS], Organ Procurement and Transplantation Network [OPTN], and American Association for the Study of Liver Diseases [AASLD]) for hepatocellular carcinoma (HCC) by using magnetic resonance (MR) imaging.


MATERIALS AND METHODS
Institutional review board approval was obtained and patient consent was waived for this HIPAA-compliant, retrospective study. The LI-RADS discussed in this article refers to version 2013.1. Ten blinded readers reviewed 100 liver MR imaging studies that demonstrated observations preliminarily assigned LI-RADS scores of LR1-LR5. Diameter and major HCC features (arterial hyperenhancement, washout appearance, pseudocapsule) were recorded for each observation. LI-RADS, OPTN, and AASLD scores were assigned. Interreader agreement was assessed by using intraclass correlation coefficients and κ statistics. Scoring rates were compared by using McNemar test.


RESULTS
Overall interreader agreement was substantial for arterial hyperenhancement (0.67 [95% confidence interval {CI}: 0.65, 0.69]), moderate for washout appearance (0.48 [95%CI: 0.46, 0.50]), moderate for pseudocapsule (0.52 [95% CI: 050, 0.54]), fair for LI-RADS (0.35 [95% CI: 0.34, 0.37]), fair for AASLD (0.39 [95% CI: 0.37, 0.42]), and moderate for OPTN (0.53 [95% CI: 0.51, 0.56]). Agreement for measured diameter was almost perfect (range, 0.95-0.97). There was substantial agreement for most scores consistent with HCC. Experts agreed significantly more than did novices and were significantly more likely than were novices to assign a diagnosis of HCC (P < .001).


CONCLUSION
Two of three major features for HCC (washout appearance and pseudocapsule) have only moderate interreader agreement. Experts and novices who assigned scores consistent with HCC had substantial but not perfect agreement. Expert agreement is substantial for OPTN, but moderate for LI-RADS and AASLD. Novices were less consistent and less likely to diagnose HCC than were experts.
Twenty years experience with the gastroepiploic artery graft for CABG.

BACKGROUND
To improve the longterm outcome after CABG, several strategies have been used using arterial conduits. Our 20 years experience with the right gastroepiploic artery (GEA) graft was evaluated.


METHODS AND RESULTS
In 1352 patients having CABG with the GEA graft, (1092 men, mean 63 years, 99% multivessel disease, and mean EF 0.51), internal thoracic artery, saphenous vein, and radial artery grafts were concomitantly used in 1312 (97%), 783 (58%), and 128 (8%) patients, respectively. The mean number of distal anastomoses was 3.1, and 2.4 coronary arteries were bypassed with arterial grafts. The sites for GEA grafting were 70 anterior descending, 268 circumflex, and 1089 right coronary arteries. The operative mortality was 1.26%. In 1118 follow-up patients (82.6%), 5, 10, and 15 years survival rates were 91.7%, 81.4%, and 71.3%, and the cardiac death-free survival rates were 95.8%, 91.7%, and 88.6%, respectively. The cumulative patency rate of the GEA graft was 97.1% at 1 month, 92.3% at 1 year, 85.5% at 5 years, and 66.5% at 10 years, respectively. In 172 skeletonized GEA grafts with 233 distal anastomoses, the patency rate at immediate, 1, and 4 years after surgery was 97.6%, 92.9%, and 86.4%, respectively. In 124 patients with late (5 to 17 years) restudy, patency rate was 96% (114/119) in the left internal thoracic artery, 87% (108/124) in GEA, and 68% (67/98) in saphenous vein grafts. New stenosis was uncommon in GEA.


CONCLUSION
The GEA graft is a safe and effective arterial conduit for CABG.
A network of deep neural networks for Distant Speech Recognition

Despite the remarkable progress recently made in distant speech recognition, state-of-the-art technology still suffers from a lack of robustness, especially when adverse acoustic conditions characterized by non-stationary noises and reverberation are met.
High dose atorvastatin decreases cellular markers of immune activation without affecting HIV-1 RNA levels: results of a double-blind randomized placebo controlled clinical trial.

BACKGROUND
3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitors (statins) exhibit antiviral activity against human immunodeficiency virus type 1 (HIV-1) in vitro and may modulate the immune response to HIV infection. Studies evaluating the antiviral activity of statins have yielded conflicting results.


METHODS
We conducted a randomized, double-blind, placebo-controlled crossover trial to investigate the effect of atorvastatin on HIV-1 RNA (primary objective) and cellular markers of immune activation (secondary objective). HIV-infected individuals not receiving antiretroviral therapy were randomized to receive either 8 weeks of atorvastatin (80 mg) or placebo daily. After a 4-6 week washout phase, participants switched treatment assignments. The study had 80% power to detect a 0.3 log(10) decrease in HIV-1 RNA level. Expression of CD38 and HLA-DR on CD4(+) and CD8(+) T cells was used to measure immune activation.


RESULTS
Of 24 randomized participants, 22 completed the study. Although HIV-1 RNA level was unaffected by the intervention (-0.13 log(10) copies/mL; P = .85), atorvastatin use resulted in reductions in circulating proportions of CD4(+) HLA-DR(+) (-2.5%; P = .02), CD8(+) HLA-DR(+) (-5%; P = .006), and CD8(+) HLA-DR(+) CD38(+) T cells (-3%; P = .03). Reductions in immune activation did not correlate with declines in serum levels of low-density lipoprotein cholesterol.


CONCLUSIONS
Short-term use of atorvastatin was associated with modest but statistically significant reductions in the proportion of activated T lymphocytes.
Performance of Different Mobile Payment Service Concepts Compared with a NFC-Based Solution

The paper compares the performance of different traditional mobile payment service concepts with a state of the art NFC-based mobile payment solution. The goal is to evaluate the different mobile payment concepts, not their software implementation, from a performance and end-to-end service duration time point of view. Overall, there have been five different mobile payment services developed, implemented and benchmarked for the concept comparison, namely: Interactive Voice Response, Short Message Service, Wireless Application Protocol, One Time Password Generator as well as a solution based on Near Field Communication.
Free-Variable Tableaux for Constant-Domain Quantified Modal Logics with Rigid and Non-rigid Designation

This paper presents a sound and complete free-variable tableau calculus for constant-domain quantified modal logics, with a propositional analytical basis, i.e. one of the systems K, D, T, K4, S4. The calculus is obtained by addition of the classical free-variable ?-rule and the "liberalized" ?+-rule [14] to a standard set of propositional rules. Thus, the proposed system characterizes proof-theoretically the constant-domain semantics, which cannot be captured by "standard" (non-prefixed, non-annotated) ground tableau calculi. The calculi are extended so as to deal also with non-rigid designation, by means of a simple numerical annotation on functional symbols, conveying some semantical information about the worlds where they are meant to be interpreted.
Learning styles and strategies preferences of Iranian medical students in gross anatomy courses and their correlations with gender

The learning approaches can help anatomy teachers design a suitable curriculum in harmony with their students' learning styles. The research objective is to evaluate gross anatomy learning styles and strategies preferences of Iranian medical students at Kashan University of Medical Sciences (KAUMS). This cross-sectional questionnaire-based study was carried out on 237 Iranian medical students. The students answered questions on approaches to learning anatomy and expressed opinions about learning anatomy in medical curriculum. The data were analyzed to disclose statistically significant differences between male and female students. Iranian male and female students were interested in learning anatomy using notes, plastic models, pictures and diagrams, clinical context, dissection and prosection of cadavers; however, they rarely used cross-sectional images and web-based resources. Both groups of medical students used region and system in learning anatomy. However, there existed some striking differences, particularly in having difficulty in studying anatomy using cadaveric specimens, using books alone, and learning it in small groups. Male students were less interested in learning with cadavers than female counterparts. However, female students were more interested in learning anatomy in small groups. This study suggests that instructors should design gross anatomy curriculum based on limitations of using dissection of cadaver in Iranian universities, emphasis on the applied anatomy, and learning of gross anatomy in small groups.
Current map-matching algorithms for transport applications : state-ofthe art and future research directions

Map-matching algorithms integrate positioning data with spatial road network data (roadway centrelines) to identify the correct link on which a vehicle is travelling and to determine the location of a vehicle on a link. A map-matching algorithm could be used as a key component to improve the performance of systems that support the navigation function of intelligent transport systems (ITS). The required horizontal positioning accuracy of such ITS applications is in the range of 1 m to 40 m (95%) with relatively stringent requirements placed on integrity (quality), continuity and system availability. A number of map-matching algorithms have been developed by researchers around the world using different techniques such as topological analysis of spatial road network data, probabilistic theory, Kalman filter, fuzzy logic, and belief theory. The performances of these algorithms have improved over the years due to the application of advanced techniques in the map matching processes and improvements in the quality of both positioning and spatial road network data. However, these algorithms are not always capable of supporting ITS applications with high required navigation performance, especially in difficult and complex environments such as dense urban areas. This suggests that research should be directed at identifying any constraints and limitations of existing map matching algorithms as a prerequisite for the formulation of algorithm improvements. The objectives of this paper are thus to uncover the constraints and limitations by an in-depth literature review and to recommend ideas to address them. This paper also highlights the potential impacts of the forthcoming European Galileo system and the European Geostationary Overlay Service (EGNOS) on the performance of map matching algorithms. Although not addressed in detail, the paper also presents some ideas for monitoring the integrity of mapmatching algorithms. The map-matching algorithms considered in this paper are generic and do not assume knowledge of ‘future’ information (i.e. based on either cost or time). Clearly, such data would result in relatively simple map-matching algorithms. 2007 Elsevier Ltd. All rights reserved.
Light-to-moderate drinking and incident heart failure--the Norwegian HUNT study.

BACKGROUND
We analyzed the association between light-to-moderate alcohol intake and the risk of heart failure (HF).


METHODS AND RESULTS
We studied 60,665 individuals free of HF who provided information on alcohol consumption in a population-based cohort study conducted in 1995-97 in Norway. Sociodemographic factors, cardiovascular risk factors and common chronic disorders were assessed by questionnaires and/or by a clinical examination. The cohort was followed for a first HF event for an average of 11.2 ± 3.0 years. Mean alcohol consumption was 2.95 ± 4.5 g/day; 1588 HF cases occurred during follow-up. The quantity of alcohol consumption was inversely associated with incident HF in this low-drinking population. The risk was lowest for consumption over three but less than six drinks/week; the multivariate hazard ratio when comparing this category to non-drinkers was 0.67 (95% CI: 0.50-0.92). Among problem drinkers based on CAGE questionnaires, total consumption showed no favorable association with HF, even when overall consumption was otherwise moderate. Excluding former drinkers and controlling for common chronic diseases had minimal effect on these associations. Frequent alcohol consumption, i.e. more than five times/month, was associated with the lowest HF risk; the adjusted hazard ratio comparing this group to alcohol intake less than once/month was 0.83 (95% CI: 0.68-1.03). We found no evidence for a differential effect according to beverage type, nor that the competing risks of death from other causes modified the association.


CONCLUSIONS
Frequent light-to-moderate alcohol consumption without problem drinking was associated with a lower HF risk in this population characterized by a low average alcohol intake.
Is a combination of varenicline and nicotine patch more effective in helping smokers quit than varenicline alone? A randomised controlled trial

BACKGROUND
Nicotine replacement therapy (NRT) and varenicline are both effective in helping smokers quit. There is growing interest in combining the two treatments to improve treatment outcomes, but no experimental data exist on whether this is efficacious. This double-blind randomised controlled trial was designed to evaluate whether adding nicotine patches to varenicline improves withdrawal relief and short-term abstinence rates.


METHODS
117 participants seeking help to stop smoking were randomly allocated to varenicline plus placebo patch or varenicline plus nicotine patch (15 mg/16 hour). Varenicline use commenced one week prior to the target quit date (TQD), patch use started on the TQD. Ratings of urges to smoke and cigarette withdrawal symptoms were collected weekly over 4 weeks post-TQD. Medication use and smoking status were established at 1, 4 and 12 weeks. Participants lost to follow-up were included as continuing smokers.


RESULTS
92% of participants used both medications during the first week after the TQD. The combination treatment generated no increase in nausea or other adverse effects. It had no overall effect on urges to smoke or on other withdrawal symptoms. The combination treatment did not improve biochemically validated abstinence rates at 1 week and 4 weeks post-TQD (69% vs 59%, p=0.28 and 60% vs 59%, p=0.91, in the nicotine patch and placebo patch arm, respectively), or self reported abstinence rates at 12 weeks (36% vs. 29%, p=0.39, NS).


CONCLUSIONS
The efficacy of varenicline was not enhanced by the addition of nicotine patches, although further trials would be useful to exclude the possibility of type II error.


TRIAL REGISTRATION
Clinicaltrials.gov


REGISTRATION NUMBER
NCT01184664.
The Semantic Interpretation of Nominal Compounds

This paper briefly introduces an approach to the problem of building semantic interpretations of nominal ComDounds, i.e. sequences of two or more nouns related through modification. Examples of the kinds of nominal compounds dealt with are: "engine repairs", "aircraft flight arrival", ~aluminum water pump", and "noun noun modification".
Analysis and design of a parallel-connected single active bridge DC-DC converter for high-power wind farm applications

This paper presents a parallel-connected Single Active Bridge (SAB) dc-dc converter for high-power applications. Paralleling lower-power converters can lower the current rating of each modular converter and interleaving the outputs can significantly reduce the magnitudes of input and output current ripples without increasing switching losses or device stresses. Analysis of both the input and output current characteristics and design aspects of the transformer, the filter inductor, and the input and output filter capacitors will be presented. Considering the high maintenance cost and fault tolerant requirements, this modular converter concept is expected to be highly beneficial especially for the offshore wind farm application.
The effect of sildenafil on human vascular function, platelet activation, and myocardial ischemia.

OBJECTIVE
We studied the effects of sildenafil, a phosphodiesterase 5 inhibitor, on coronary and peripheral vascular function, platelet activation, and myocardial ischemia.


BACKGROUND
Nitric oxide vasodilates and inhibits platelet activation by generating cyclic guanosine 5'-monophosphate, which is metabolized by phosphodiesterase type 5.


METHODS
The effect of oral sildenafil on resting coronary vascular tone, endothelium-dependent and -independent function and platelet activation was measured in 24 patients. An additional 24 patients with coronary artery disease (CAD) and ischemia during exercise, and 12 control subjects received either 100 mg of sildenafil, 10 mg of isosorbide dinitrate (ISDN) or placebo during exercise on three separate days in a randomized, double-blind manner. Flow-mediated dilation of the brachial artery was measured, and CAD patients underwent treadmill exercise testing.


RESULTS
Sildenafil (100 mg) vasodilated epicardial coronary arteries (+6.9 +/- 1.3%, p < 0.0001). Coronary epicardial and microvascular responses with acetylcholine and cold-pressor testing improved, with a greater enhancement in patients with CAD and endothelial dysfunction. Verapamil responses were unchanged. Both resting and adenosine diphosphate-stimulated platelet IIb/IIIa receptor activation was inhibited by sildenafil (p < 0.05). Brachial arteries dilated in response to sildenafil in controls. Peak flow-mediated dilation was similar, but the duration of hyperemia was prolonged after sildenafil administration (p < 0.001). Compared with placebo, ISDN improved myocardial ischemia during exercise (p < 0.05), whereas the effect of sildenafil was intermediate between the two.


CONCLUSIONS
Sildenafil dilates epicardial coronary arteries, improves endothelial dysfunction and inhibits platelet activation in patients with CAD. It has an intermediate effect on myocardial ischemia compared with ISDN and placebo.
Central Coherence, Visuoconstruction and Visual Memory in Patients with Eating Disorders as Measured by Different Scoring Methods of the Rey Complex Figure Test.

OBJECTIVE
The aims of this study were to examine the performance of eating disorder (ED) patients on the Rey Complex Figure Test and to investigate the validity of the Q-score as a new method for measuring central coherence (CC).


METHOD
Forty-one patients with anorexia nervosa, 40 patients with bulimia nervosa and 40 healthy controls completed the Rey Complex Figure Test, which was scored both quantitatively and qualitatively.


RESULTS
Both ED groups scored lower than the healthy controls on copy, recall and the Q-score. For the anorexia nervosa group, performance on the Central Coherence Index was associated with the nadir body mass index. Performance on the recall measures was independently associated with the nadir body mass index and depressive symptoms for the bulimia nervosa group. There was a strong correlation between the Q-score and the Central Coherence Index (r = 0.77).


DISCUSSION
The study reveals different levels of CC and suggests that the Q-score might be an applicable method for measuring CC in ED patients.
A simpler and faster 1.5-approximation algorithm for sorting by transpositions

An important problem in genome rearrangements is sorting permutations by transpositions. The complexity of the problem is still open, and two rather complicated 1.5-approximation algorithms for sorting linear permutations are known (Bafna and Pevzner, 98 and Christie, 99). The fastest known algorithm is the quadratic algorithm of Bafna and Pevzner. In this paper, we observe that the problem of sorting circular permutations by transpositions is equivalent to the problem of sorting linear permutations by transpositions. Hence, all algorithms for sorting linear permutations by transpositions can be used to sort circular permutations. Our main result is a new O(n3/2 √ log n) 1.5-approximation algorithm, which is considerably simpler than the previous ones, and whose analysis is significantly less involved. © 2005 Elsevier Inc. All rights reserved.
Radiofrequency ablation of atrial fibrillation: is the persistence of all intraprocedural targets necessary for long-term maintenance of sinus rhythm?

BACKGROUND
Several approaches have been developed for radiofrequency catheter ablation of atrial fibrillation, but the correct intraprocedural end point is still under debate, and few data exist about the destiny of ablation lesions over time. The aim of the present study was to evaluate the long-term maintenance of intraprocedural end points of ablation procedures.


METHODS AND RESULTS
Inclusion criteria were (1) a previous ablation procedure of pulmonary vein (PV) encircling performed for drug-refractory persistent atrial fibrillation; (2) a "complete" intraprocedural end point, which consisted of voltage abatement inside the lesions, PV disconnection, and exit-block pacing from inside the lesions, attained in all PVs; and (3) stable sinus rhythm documented during a minimum follow-up of 2.5 years after the procedure. Twenty volunteers were selected (12 males, mean age 59+/-7 years) and underwent a repeat electrophysiological study. After a follow-up of 36.4+/-4.7 months, complete voltage abatement was maintained around 32 PVs (40.0%), PV disconnection persisted in 12 (37.5%) of the previously isolated PVs, and exit block was present in 39 PVs (48.7%). Ten patients who underwent a redo ablation procedure because of recurrences of atrial fibrillation were used as the control group. Differences in intraprocedural end-point maintenance between the 2 groups were not statistically significant.


CONCLUSIONS
Common intraprocedural end points such as voltage abatement, PV disconnection, and exit block persist only in a limited number of patients, even when the outcome is favorable during follow-up. Further investigation will be required to determine whether such data will have implications for ablation strategies.
Performance Evaluation of Transaction Processing Systems

Performance and price/performance are important attributes to consider when evaluating a transaction processing system. Two major approaches to performance evaluation are measurement and modeling. TPC Benchmark A is an industry standard benchmark for measuring a transaction processing system’s performance and price/performance. Digital has implemented TPC Benchmark A in a distributed transaction processing environment. Benchmark measurements were performed on the VAX 9000 Model 210 and the VAX 4000 Model 300 systems. Further, a comprehensive analytical model was developed and customized to model the performance behavior of TPC Benchmark A on Digital’s transaction processing platforms. This model was validated using measurement results and has proven to be an accurate performance prediction tool.