LLukas22/scidocs huggingface dataset:
Sex hormone-binding globulin concentrations before conception as a predictor for gestational diabetes in women with polycystic ovary syndrome.

BACKGROUND
Low plasma sex hormone-binding globulin (SHBG) concentrations during pregnancy have been associated with the risk of developing gestational diabetes mellitus (GDM). Women presenting with polycystic ovary syndrome (PCOS) often exhibit low plasma SHBG concentration and are at increased risk of developing GDM. In this study, we investigate whether SHBG levels before conception are predictive of GDM in women with PCOS.


METHODS
A total of 50 women with PCOS were enrolled and followed up during pregnancy. Initial endocrine, metabolic and physical features were assessed according to a standardized preconception screening program. At 24-26 weeks of gestational age a 100-g glucose tolerance test was performed to screen for GDM.


RESULTS
Of the 50 women, 21 (42%) were diagnosed with GDM by a 100-g glucose tolerance test. Waist circumference, BMI, blood pressure, plasma glucose, insulin, homeostasis model assessment-insulin resistance (HOMA-IR) and SHBG levels before conception were significantly different between women who did and did not develop GDM. Stepwise logistic regression analysis showed that SHBG was the most significant predictive parameter for GDM (odds ratio 0.92; 95% confidence interval 0.87-0.97), without significant contribution of waist circumference and HOMA-IR. Receiver operator characteristic (ROC) analysis indicated that plasma SHBG (area under the curve 0.86) had the highest predictive value for subsequent development of GDM, however, the limited group size did not allow for calculation of a threshold value of SHBG.


CONCLUSIONS
In women with PCOS, preconception SHBG levels are strongly associated with subsequent development of GDM. Regression and ROC analysis show that preconception SHBG levels may be a better predictor for GDM in PCOS women compared with waist circumference or HOMA-IR.


CLINICAL TRIAL REGISTRATION NUMBER
NCT00821379.
Corticosterone Administration Alters Small Intestinal Morphology and Function of Broiler Chickens

Two experiments were carried out to study the effects of corticosterone (CORT) administration on intestinal morphology and function of broilers. In both experiments, birds were randomly divided into two equal groups. One group was the control group (CTRL), and the birds were fed with a basal diet. The other was the experimental group (CORT), and the birds were fed with the basal diet plus 30 mg of CORT/kg diet. At 21 days of age, performance, morphological characteristics of intestine, D-xylose level in plasma, activities of digestive enzymes in digesta, digestibility of nutrients and 5-bromo-2-deoxyuridine (BrdUrd)-labeling index of intestinal epithelial cells were determined. CORT administration decreased feed intake, daily gain and feed conversion ratio (p<0.05). CORT also decreased duodenal and jejunal villus height (p<0.05) as well as crypt depth (p<0.05). The D-xylose level in plasma of CORT-treated broilers was lower than that of the control (p<0.05). CORT treatment caused a decrease in apparent digestibility of protein (p<0.05), whereas fat and starch apparent digestibilities were unaffected (p>0.05). CORT administration increased activities of trypsin and amylase (p<0.05), and decreased BrdUrd-labeling index of duodenal and jejunal epithelial cells (p<0.05). In conclusion, CORT administration impaired the normal morphology and absorptive capacity of the small intestine of broiler chickens. (
Approximate entropy (ApEn) as a complexity measure.

Approximate entropy (ApEn) is a recently developed statistic quantifying regularity and complexity, which appears to have potential application to a wide variety of relatively short (greater than 100 points) and noisy time-series data. The development of ApEn was motivated by data length constraints commonly encountered, e.g., in heart rate, EEG, and endocrine hormone secretion data sets. We describe ApEn implementation and interpretation, indicating its utility to distinguish correlated stochastic processes, and composite deterministic/ stochastic models. We discuss the key technical idea that motivates ApEn, that one need not fully reconstruct an attractor to discriminate in a statistically valid manner-marginal probability distributions often suffice for this purpose. Finally, we discuss why algorithms to compute, e.g., correlation dimension and the Kolmogorov-Sinai (KS) entropy, often work well for true dynamical systems, yet sometimes operationally confound for general models, with the aid of visual representations of reconstructed dynamics for two contrasting processes. (c) 1995 American Institute of Physics.
A 3 DOF Piezohydraulic Parallel Micromanipulator

The paper presents a new parallel micromanipulator that is composed of three piezohydraulic actuation systems. The basic elements of the actuation system are a piezoelectric actuator, a bellows and hydraulic oil. The use of the flexible bellows results in a new type of parallel structure, where the joints are integrated into actuator links. The joint-free tripod-like micromanipulator is controlled using a real-time control software that is based on a multi-level architecture. Control is organised in four levels for non-linearity compensation, position feedback control, supervision and tackling of automatic operations. The presented micromanipulator provides an exceptional combination of submicrometer resolution, large work space, miniature size and advanced control.
Belowground nitrogen partitioning in experimental grassland plant communities of varying species richness.

Partitioning of soil nitrogen (N) by niche separation among species may be an important mechanism explaining species coexistence and positive biodiversity-productivity relationships in terrestrial plant communities. However, there is little experimental evidence for such partitioning, in particular, as assessed across a gradient of species richness. In experimental communities of one, three, and six temperate grassland species in the field, we tested whether increasing species richness (1) decreases niche breadths of individual species, (2) decreases niche overlap among species, and (3) increases niche breadth of whole communities. Six N sources consisting of three different chemical forms of 15N-labeled N (15NO3(-), 15NH4+, 13C2-15N-glycine) injected at two soil depths (3 and 12 cm) were applied to each community. The chemical form and the soil depth of N characterize the niches for which niche breadth (Levins' B) and overlap (proportional similarity) were measured. After 48 hours, aboveground plant material was harvested to measure 15N enrichment. As expected, niche breadth of single species and niche overlap among species decreased with increased species richness, but community niche breadth did not increase. The decrease in niche breadth and niche overlap mostly occurred among subordinate species or pairs of subordinate and dominant species, rather than among dominant species. Species in the six-species mixtures mostly preferred NO3(-) from shallow soil. This may be partly explained by the presence of legumes in all six-species mixtures which allowed "N sparing" (i.e., increased availability of soil N since legumes rely more on atmospheric N2 than on soil N). Niche separation with respect to N uptake from different chemical forms and soil depths did not contribute much to facilitating the coexistence of dominant species, nor do our results suggest it as a major driver of positive diversity-ecosystem functioning relationships. However, partitioning of N may be important for the persistence of subordinate species.
Effects of Balloon Pulmonary Angioplasty on Oxygenation in Patients With Chronic Thromboembolic Pulmonary Hypertension　- Importance of Intrapulmonary Shunt.

BACKGROUND
Although balloon pulmonary angioplasty (BPA) improves the hemodynamics and prognosis of patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH), the mechanisms of improvement in oxygenation remain to be elucidated.


METHODSANDRESULTS
From August 2013 to May 2015, we performed a total of 113 BPA procedures in 24 patients with inoperable CTEPH (mean 4.7 procedures per patient). Median age was 70 [60, 74] years and 18 were female (75%). We examined hemodynamics, respiratory functions, and intrapulmonary shunt before and after the BPA procedure. Mean pulmonary arterial pressure (37 [28, 45] to 23[19, 27] mmHg, P<0.01), pulmonary vascular resistance (517 [389, 696] to 268 [239, 345] dyne/s/cm(5)) and 6-min walk distance (390 [286, 484] to 490 [411, 617] m, P<0.01) were significantly improved after BPA therapy. Furthermore, arterial oxygen partial pressure (PaO2, 54.8 [50.0, 60.8] to 65.2 [60.6, 73.2] %, P<0.01) and intrapulmonary shunt (23.4±6.0% to 19.3±5.0%, P<0.01) were also significantly ameliorated. In the multivariate analysis, decrease in intrapulmonary shunt after BPA was significantly correlated with improvement of both PaO2(r(2)=0.26, P<0.01) and SaO2(r(2)=0.49, P<0.01) after BPA.


CONCLUSIONS
These results indicated that BPA improved not only pulmonary hemodynamics but also oxygenation with a resultant decrease in intrapulmonary shunt. (Circ J 2016; 80: 2227-2234).
Deep Structured Output Learning for Unconstrained Text Recognition

We develop a representation suitable for the unconstrained recognition of words in natural images, where unconstrained means that there is no fixed lexicon and words have unknown length. To this end we propose a convolutional neural network (CNN) based architecture which incorporates a Conditional Random Field (CRF) graphical model, taking the whole word image as a single input. The unaries of the CRF are provided by a CNN that predicts characters at each position of the output, while higher order terms are provided by another CNN that detects the presence of N-grams. We show that this entire model (CRF, character predictor, N-gram predictor) can be jointly optimised by back-propagating the structured output loss, essentially requiring the system to perform multi-task learning, and training requires only synthetically generated data. The resulting model is a more accurate system on standard real-world text recognition benchmarks than character prediction alone, setting a benchmark for systems that have not been trained on a particular lexicon. In addition, our model achieves state-of-the-art accuracy in lexicon-constrained scenarios, without being specifically modelled for constrained recognition. To test the generalisation of our model, we also perform experiments with random alpha-numeric strings to evaluate the method when no visual language model is applicable.
Self-determination theory and work motivation

Cognitive evaluation theory, which explains the effects of extrinsic motivators on intrinsic motivation, received some initial attention in the organizational literature. However, the simple dichotomy between intrinsic and extrinsic motivation made the theory difficult to apply to work settings. Differentiating extrinsic motivation into types that differ in their degree of autonomy led to self-determination theory, which has received widespread attention in the education, health care, and sport domains. This article describes self-determination theory as a theory of work motivation and shows its relevance to theories of organizational behavior. Copyright # 2005 John Wiley & Sons, Ltd.
On the Stability of the Passive Dynamics of Quadrupedal Running with a Bounding Gait

This paper examines the passive dynamics of quadrupedal bounding. First, an unexpected difference between local and global behavior of the forward speed versus touchdown angle in the selfstabilized Spring Loaded Inverted Pendulum (SLIP) model is exposed and discussed. Next, the stability properties of a simplified sagittal plane model of our Scout II quadrupedal robot are investigated. Despite its simplicity, this model captures the targeted steady state behavior of Scout II without dependence on the fine details of the robot structure. Two variations of the bounding gait, which are observed experimentally in Scout II, are considered. Surprisingly, numerical return map studies reveal that passive generation of a large variety of cyclic bounding motion is possible. Most strikingly, local stability analysis shows that the dynamics of the open loop passive system alone can confer stability to the motion! These results can be used in developing a general control methodology for legged robots, resulting from the synthesis of feedforward and feedback models that take advantage of the mechanical sysPortions of this paper have previously appeared in conference publications Poulakakis, Papadopoulos, and Buehler (2003) and Poulakakis, Smith, and Buehler (2005b). The first and third authors were with the Centre for Intelligent Machines at McGill University when this work was performed. Address all correspondence related to this paper to the first author. The International Journal of Robotics Research Vol. 25, No. 7, July 2006, pp. 669-687 DOI: 10.1177/0278364906066768 ©2006 SAGE Publications Figures appear in color online: http://ijr.sagepub.com tem, and might explain the success of simple, open loop bounding controllers on our experimental robot. KEY WORDS—passive dynamics, bounding gait, dynamic running, quadrupedal robot
Operationalizing frailty among older residents of assisted living facilities

BACKGROUND
Frailty in later life is viewed as a state of heightened vulnerability to poor outcomes. The utility of frailty as a measure of vulnerability in the assisted living (AL) population remains unexplored. We examined the feasibility and predictive accuracy of two different interpretations of the Cardiovascular Health Study (CHS) frailty criteria in a population-based sample of AL residents.


METHODS
CHS frailty criteria were operationalized using two different approaches in 928 AL residents from the Alberta Continuing Care Epidemiological Studies (ACCES). Risks of one-year mortality and hospitalization were estimated for those categorized as frail or pre-frail (compared with non-frail). The prognostic significance of individual criteria was explored, and the area under the ROC curve (AUC) was calculated for select models to assess the utility of frailty in predicting one-year outcomes.


RESULTS
Regarding feasibility, complete CHS criteria could not be assessed for 40% of the initial 1,067 residents. Consideration of supplementary items for select criteria reduced this to 12%. Using absolute (CHS-specified) cut-points, 48% of residents were categorized as frail and were at greater risk for death (adjusted risk ratio [RR] 1.75, 95% CI 1.08-2.83) and hospitalization (adjusted RR 1.54, 95% CI 1.20-1.96). Pre-frail residents defined by absolute cut-points (48.6%) showed no increased risk for mortality or hospitalization compared with non-frail residents. Using relative cut-points (derived from AL sample), 19% were defined as frail and 55% as pre-frail and the associated risks for mortality and hospitalization varied by sex. Frail (but not pre-frail) women were more likely to die (RR 1.58 95% CI 1.02-2.44) and be hospitalized (RR 1.53 95% CI 1.25-1.87). Frail and pre-frail men showed an increased mortality risk (RR 3.21 95% CI 1.71-6.00 and RR 2.61 95% CI 1.40-4.85, respectively) while only pre-frail men had an increased risk of hospitalization (RR 1.58 95% CI 1.15-2.17). Although incorporating either frailty measure improved the performance of predictive models, the best AUCs were 0.702 for mortality and 0.633 for hospitalization.


CONCLUSIONS
Application of the CHS criteria for frailty was problematic and only marginally improved the prediction of select adverse outcomes in AL residents. Development and validation of alternative approaches for detecting frailty in this population, including consideration of female/male differences, is warranted.
Long-term clinical and angiographic follow-up after coronary stent placement in native coronary arteries.

BACKGROUND
Although coronary stents have been proved effective in reducing clinical cardiac events for up to 3 to 5 years, longer term clinical and angiographic outcomes have not yet been fully clarified.


METHODS AND RESULTS
To evaluate longer term (7 to 11 years) outcome, clinical and angiographic follow-up information was analyzed in 405 patients with successful stenting in native coronary arteries. Primary or secondary stabilization, which was defined as freedom from death, coronary artery bypass grafting, and target lesion-percutaneous coronary intervention (TL-PCI) during the 14 months after the initial procedure or after the last TL-PCI, was achieved in 373 patients (92%) overall. Only 7 patients (1.7%) underwent TL-PCI more than twice. After the initial 14-month period, freedom from TL-PCI reached a plateau at 84.9% to 80.7% over 1 to 8 years. However, quantitative angiographic analysis in 179 lesions revealed a triphasic luminal response characterized by an early restenosis phase until 6 months, an intermediate-term regression phase from 6 months to 3 years, and a late renarrowing phase beyond 4 years. Minimal luminal diameter in 131 patients with complete serial data were 2.62+/-0.4 mm immediately after stenting, 2.0+/-0.49 mm at 6 months, 2.19+/-0.49 mm at 3 years, and 1.85+/-0.56 mm beyond 4 years (P<0.0001).


CONCLUSIONS
The efficacy and safety of coronary stenting seemed to be clinically sustained at 7 to 11 years of follow-up. However, late luminal renarrowing beyond 4 years was common, which demonstrates the need for further follow-up.
Study protocol of effectiveness of a biopsychosocial multidisciplinary intervention in the evolution of non-speficic sub-acute low back pain in the working population: cluster randomised trial

BACKGROUND
Non-specific low back pain is a common cause for consultation with the general practitioner, generating increased health and social costs. This study will analyse the effectiveness of a multidisciplinary intervention to reduce disability, severity of pain, anxiety and depression, to improve quality of life and to reduce the incidence of chronic low back pain in the working population with non-specific low back pain, compared to usual clinical care.


METHODS/DESIGN
A Cluster randomised clinical trial will be conducted in 38 Primary Health Care Centres located in Barcelona, Spain and its surrounding areas. The centres are randomly allocated to the multidisciplinary intervention or to usual clinical care. Patients between 18 and 65 years old (n = 932; 466 per arm) and with a diagnostic of a non-specific sub-acute low back pain are included. Patients in the intervention group are receiving the recommendations of clinical practice guidelines, in addition to a biopsychosocial multidisciplinary intervention consisting of group educational sessions lasting a total of 10 hours. The main outcome is change in the score in the Roland Morris disability questionnaire at three months after onset of pain. Other outcomes are severity of pain, quality of life, duration of current non-specific low back pain episode, work sick leave and duration, Fear Avoidance Beliefs and Goldberg Questionnaires. Outcomes will be assessed at baseline, 3, 6 and 12 months. Analysis will be by intention to treat. The intervention effect will be assessed through the standard error of measurement and the effect-size. Responsiveness of each scale will be evaluated by standardised response mean and receiver-operating characteristic method. Recovery according to the patient will be used as an external criterion. A multilevel regression will be performed on repeated measures. The time until the current episode of low back pain takes to subside will be analysed by Cox regression.


DISCUSSION
We hope to provide evidence of the effectiveness of the proposed biopsychosocial multidisciplinary intervention in avoiding the chronification of low back pain, and to reduce the duration of non-specific low back pain episodes. If the intervention is effective, it could be applied to Primary Health Care Centres.


TRIAL REGISTRATION
ISRCTN21392091.
Surgical technique: development of an anatomic medial knee reconstruction.

BACKGROUND
The main static stabilizers of the medial knee are the superficial medial collateral and posterior oblique ligaments. A number of reconstructive techniques have been advocated including one we describe here. However, whether these reconstructions restore function and stability is unclear.


DESCRIPTION OF TECHNIQUE
This anatomic reconstruction technique consisted of reconstruction of the proximal and distal divisions of the superficial medial collateral and the posterior oblique ligament using two separate grafts.


PATIENTS AND METHODS
We prospectively followed all 28 patients (19 male, nine females) who had this new reconstruction between 2007 and 2009. The average age was 32.4 years (range, 16-56 years). There were eight acute and 20 chronic injuries. All patients presented with side-to-side instability with activities of daily living and other higher level activities. Minimum followup was 6 months (average, 1.5 years; range, 0.5-3 years). No patients were lost to followup.


RESULTS
Preoperative International Knee Documentation Committee subjective outcome scores averaged 43.5 (range, 14-66) and final postoperative values averaged 76.2 (range, 54-88). Preoperative valgus stress radiographs averaged 6.2 mm of medial compartment gapping compared with the contralateral normal knee, whereas postoperative stress radiographs averaged 1.3 mm.


CONCLUSIONS
Early observations suggest this anatomic reconstruction technique improves overall patient function and restores valgus instability.
Facial expression recognition from video sequences: temporal and static modeling

The most expressive way humans display emotions is through facial expressions. In this work we report on several advances we have made in building a system for classification of facial expressions from continuous video input. We introduce and test different Bayesian network classifiers for classifying expressions from video, focusing on changes in distribution assumptions, and feature dependency structures. In particular we use Naive–Bayes classifiers and change the distribution from Gaussian to Cauchy, and use Gaussian Tree-Augmented Naive Bayes (TAN) classifiers to learn the dependencies among different facial motion features. We also introduce a facial expression recognition from live video input using temporal cues. We exploit the existing methods and propose a new architecture of hidden Markov models (HMMs) for automatically segmenting and recognizing human facial expression from video sequences. The architecture performs both segmentation and recognition of the facial expressions automatically using a multi-level architecture composed of an HMM layer and a Markov model layer. We explore both person-dependent and person-independent recognition of expressions and compare the different methods. 2003 Elsevier Inc. All rights reserved. * Corresponding author. E-mail addresses: iracohen@ifp.uiuc.edu (I. Cohen), nicu@science.uva.nl (N. Sebe), ashutosh@ us.ibm.com (A. Garg), lawrence.chen@kodak.com (L. Chen), huang@ifp.uiuc.edu (T.S. Huang). 1077-3142/$ see front matter 2003 Elsevier Inc. All rights reserved. doi:10.1016/S1077-3142(03)00081-X I. Cohen et al. / Computer Vision and Image Understanding 91 (2003) 160–187 161