LLukas22/scidocs huggingface dataset:
Modeling crosstalk in statistical static timing analysis

Increasing process variation in the nanometer regime motivates the use of statistical static timing analysis tools for timing verification. As device dimensions get smaller, signal integrity effects such as crosstalk noise become more significant. Therefore, it is necessary to accurately model the impact of crosstalk noise on the circuit delay. Process variations cause variability in the crosstalk alignment which leads to the variability in the delay noise. However, most of the existing approaches model delay noise as a worst-case deterministic quantity. In this work, we capture the variability of delay noise by first deriving the closed-form expressions of mean and standard deviation of the delay noise distribution. Next, we obtain the correlation information of the delay noise and use it to represent the delay noise distribution in canonical form. Delay noise, in canonical form, can easily be integrated with existing SSTA tools. We show experimental results that verify the accuracy of our approach.
TMVA - Toolkit for multivariate data analysis

In high-energy physics, with the search for ever smaller signals in ever larger data sets, it has become essential to extract a maximum of the available information from the data. Multivariate classification methods based on machine learning techniques have become a fundamental ingredient to most analyses. Also the multivariate classifiers themselves have significantly evolved in recent years. Statisticians have found new ways to tune and to combine classifiers to further gain in performance. Integrated into the analysis framework ROOT, TMVA is a toolkit which hosts a large variety of multivariate classification algorithms. Training, testing, performance evaluation and application of all available classifiers is carried out simultaneously via user-friendly interfaces. With version 4, TMVA has been extended to multivariate regression of a real-valued target vector. Regression is invoked through the same user interfaces as classification. TMVA 4 also features more flexible data handling allowing one to arbitrarily form combined MVA methods. A generalised boosting method is the first realisation benefiting from the new framework.
CT angiography signs of lower extremity vascular trauma.

OBJECTIVE
Specific CT angiography (CTA) signs of vascular injury can be readily detected, and additional information regarding osseous and soft-tissue injuries can also be routinely obtained. In this article, we illustrate the important CTA signs of lower extremity vascular injury.


CONCLUSION
CTA is efficient and accurate in the evaluation of clinically significant lower extremity arterial injuries after trauma.
Fatigue behavior of Ilizarov frame versus tibial interlocking nail in a comminuted tibial fracture model: a biomechanical study

BACKGROUND
Treatment options for comminuted tibial shaft fractures include plating, intramedullary nailing, and external fixation. No biomechanical comparison between an interlocking tibia nail with external fixation by an Ilizarov frame has been reported to date. In the present study, we compared the fatigue behaviour of Ilizarov frames to interlocking intramedullary nails in a comminuted tibial fracture model under a combined loading of axial compression, bending and torsion. Our goal was to determine the biomechanical characteristics, stability and durability for each device over a clinically relevant three month testing period. The study hypothesis was that differences in the mechanical properties may account for differing clinical results and provide information applicable to clinical decision making for comminuted tibia shaft fractures.


METHODS
In this biomechanical study, 12 composite tibial bone models with a comminuted fracture and a 25 mm diaphyseal gap were investigated. Of these, six models were stabilized with a 180-mm four-ring Ilizarov frame, and six models were minimally reamed and stabilized with a 10 mm statically locked Russell-Taylor Delta tibial nail. After measuring the pre-fatigue axial compression bending and torsion stiffness, each model was loaded under a sinusoidal cyclic combined loading of axial compression (2.8/28 lbf; 12.46/124.6 N) and torque (1.7/17 lbf-in; 0.19/1.92 Nm) at a frequency of 3 Hz. The test was performed until failure (implant breakage or >or= 5 degrees angulations and/or 2 cm shortening) occurred or until 252,000 cycles were completed, which corresponds to approximately three months testing period.


RESULTS
In all 12 models, both the Ilizarov frame and the interlocking tibia nail were able to maintain fracture stability of the tibial defect and to complete the full 252,000 cycles during the entire study period of three months. A significantly higher stiffness to axial compression and torsion was demonstrated by the tibial interlocking nail model, while the Ilizarov frame provided a significantly increased range of axial micromotion.


CONCLUSION
This is the first study, to our knowledge, which compares the biomechanical properties of an intramedullary nail to an external Ilizarov frame to cyclic axial loading and torsion in a comminuted tibia shaft fracture model. Prospective, randomized trials comparing Ilizarov frames and interlocked tibial nails are needed to clarify the clinical impact of these biomechanical findings.
Android application for stock market prediction by fuzzy logic

Presently, firms in financial services sector like banking and insurance make profits by investing their clients' money in stock markets, the strategies for which are heavily infrastructure dependent and unknown outside the organization. This paper discusses the development of an android application which can be made available directly to the common investors from unorganized sector. The application uses rule based fuzzy logic [1, 2, 3, 4] for analyzing the direction of stock market movement. We report emulation on BlueStacks App Player [5].
Long-term treatment of transsexuals with cross-sex hormones: extensive personal experience.

CONTEXT
Transsexuals receive cross-sex hormone treatment. Its short-term use appears reasonably safe. Little is known about its long-term use. This report offers some perspectives.


SETTING
The setting was a university hospital serving as the national referral center for The Netherlands (16 million people).


PATIENTS
From the start of the gender clinic in 1975 up to 2006, 2236 male-to-female and 876 female-to-male transsexuals have received cross-sex hormone treatment. In principle, subjects are followed up lifelong.


INTERVENTIONS
Male-to-female transsexuals receive treatment with the antiandrogen cyproterone acetate 100 mg/d plus estrogens (previously 100 microg ethinyl estradiol, now 2-4 mg oral estradiol valerate/d or 100 microg transdermal estradiol/d). Female-to-male transsexuals receive parenteral testosterone esters 250 mg/2 wk. After 18-36 months, surgical sex reassignment including gonadectomy follows, inducing a profound hypogonadal state.


MAIN OUTCOME MEASURES
Outcome measures included morbidity and mortality data and data assessing risks of osteoporosis and cardiovascular disease.


RESULTS
Mortality was not higher than in a comparison group. Regarding morbidity, with ethinyl estradiol, there was a 6-8% incidence of venous thrombosis, which is no longer the case with use of other types of estrogens. Continuous use of cross-sex hormones is required to prevent osteoporosis. Androgen deprivation plus an estrogen milieu in male-to-female transsexuals has a larger deleterious effect on cardiovascular risk factors than inducing an androgenic milieu in female-to-male transsexuals, but there is so far no elevated cardiovascular morbidity/mortality. Low numbers of endocrine-related cancers have been observed in male-to-female transsexuals.


CONCLUSIONS
Cross-sex hormone treatment of transsexuals seems acceptably safe over the short and medium term, but solid clinical data are lacking.
Artificial Neural Network based Web Application Firewall for SQL Injection

In recent years with the rapid development of Internet and the Web, more and more web applications have been deployed in many fields and organizations such as finance, military, and government. Together with that, hackers have found more subtle ways to attack web applications. According to international statistics, SQL Injection is one of the most popular vulnerabilities of web applications. The consequences of this type of attacks are quite dangerous, such as sensitive information could be stolen or authentication systems might be by-passed. To mitigate the situation, several techniques have been adopted. In this research, a security solution is proposed using Artificial Neural Network to protect web applications against this type of attacks. The solution has been experimented on sample datasets and has given promising result. The solution has also been developed in a prototypic web application firewall called ANNbWAF. Keywords—Artificial Neural Networks ANN, SQL Injection, Web Application Firewall WAF, Web Application Scanner WAS.
Perceptions of health status in multiple sclerosis patients and their doctors.

OBJECTIVE
To compare neurologist and patient perceptions of multiple sclerosis (MS)-related health status.


METHODS
MS patients (n=99) were recruited from six sites in Canada. Following a consultation with their neurologist, patients estimated their relapse frequency, rated their general health and quality of life (QoL), reviewed descriptions of eight health domains and selected the three most important, and completed a utility assessment using the standard gamble (SG). Concurrently, neurologists independently used the same instruments to rate their patients' health status. Assessments were compared on the basis of paired mean values of both groups and the degree of exact agreement quantified by intraclass coefficient (ICC) and kappa analyses, which yield values of 1.0 with 100% agreement.


RESULTS
There were significant differences (p<0.001) between patient and neurologist ratings for relapses in the last year (0.86 vs. 0.4, respectively), QoL (61.2 vs. 69.7 (maximum score = 100) and utility (0.864 vs. 0.971); ICC analysis revealed moderate to poor levels of agreement (0.56 for QoL to 0.03 for SG). There was little concordance in identification of important health domain and the only significant associations were in bodily pain and social functioning (kappa statistic = 0.24, p = 0.026 for both). Neurologists identified physical functioning domains as important, while patients placed more emphasis on mental health domains.


CONCLUSIONS
Discrepancies between neurologist and patient perceptions of MS were observed. The study identifies a need to educate neurologists on the recognition of MS health domains that are important in the definition of patient QoL.
Increases in plasma carotenoid concentrations in response to a major dietary change in the women's healthy eating and living study.

BACKGROUND
Cohort studies suggest that higher circulating carotenoid concentrations through food sources may reduce breast cancer events. Other intervention studies have not achieved the level of change in circulating carotenoids required to properly test this hypothesis.


METHODS
In a randomized trial of 2,922 breast cancer survivors, we examined blood and self-reported diet at baseline and 1 year. Intensive telephone counseling encouraged a plant-based diet in the intervention group. Diet was measured via 24-hour recalls, and a panel of plasma carotenoid concentrations was assessed at both time points.


RESULTS
The study intervention was associated with a 51% increase in total carotenoid concentration, from 2.272 +/- 1.294 to 3.440 +/- 2.320 micromol/L, achieved mainly by marked increases in targeted carotenoids: alpha-carotene, beta-carotene, and lutein. For each of these targeted carotenoids, the proportion of the intervention sample remaining below the cutpoint for the lowest baseline quartile decreased by one third to one half. After 1 year of study, half of the intervention group was in the highest baseline quartile. No change in distribution was observed in comparison group. Intervention participants achieved this change by both dietary pattern and vegetable juice consumption. Participants who chose to change dietary pattern without consuming significant quantities of vegetable juice achieved 75% of the level of change observed in other intervention participants.


CONCLUSIONS
Innovative telephone counseling intervention and dietary targets in the Women's Healthy Eating and Living study were associated with the level of change in circulating carotenoid concentration necessary to test the diet and breast cancer hypothesis suggested by cohort studies.
Boosting with Subtype C CN54rgp140 Protein Adjuvanted with Glucopyranosyl Lipid Adjuvant after Priming with HIV-DNA and HIV-MVA Is Safe and Enhances Immune Responses: A Phase I Trial.

BACKGROUND
A vaccine against HIV is widely considered the most effective and sustainable way of reducing new infections. We evaluated the safety and impact of boosting with subtype C CN54rgp140 envelope protein adjuvanted in glucopyranosyl lipid adjuvant (GLA-AF) in Tanzanian volunteers previously given three immunizations with HIV-DNA followed by two immunizations with recombinant modified vaccinia virus Ankara (HIV-MVA).


METHODS
Forty volunteers (35 vaccinees and five placebo recipients) were given two CN54rgp140/GLA-AF immunizations 30-71 weeks after the last HIV-MVA vaccination. These immunizations were delivered intramuscularly four weeks apart.


RESULTS
The vaccine was safe and well tolerated except for one episode of asymptomatic hypoglycaemia that was classified as severe adverse event. Two weeks after the second HIV-MVA vaccination 34 (97%) of the 35 previously vaccinated developed Env-specific binding antibodies, and 79% and 84% displayed IFN-γ ELISpot responses to Gag and Env, respectively. Binding antibodies to subtype C Env (included in HIV-DNA and protein boost), subtype B Env (included only in HIV-DNA) and CRF01_AE Env (included only in HIV-MVA) were significantly boosted by the CN54rgp140/GLA-AF immunizations. Functional antibodies detected using an infectious molecular clone virus/peripheral blood mononuclear cell neutralization assay, a pseudovirus/TZM-bl neutralization assay or by assays for antibody-dependent cellular cytotoxicity (ADCC) were not significantly boosted. In contrast, T-cell proliferative responses to subtype B MN antigen and IFN-γ ELISpot responses to Env peptides were significantly enhanced. Four volunteers not primed with HIV-DNA and HIV-MVA before the CN54rgp140/GLA-AF immunizations mounted an antibody response, while cell-mediated responses were rare. After the two Env subtype C protein immunizations, a trend towards higher median subtype C Env binding antibody titers was found in vaccinees who had received HIV-DNA and HIV-MVA prior to the two Env protein immunizations as compared to unprimed vaccinees (p = 0.07).


CONCLUSION
We report excellent tolerability, enhanced binding antibody responses and Env-specific cell-mediated immune responses but no ADCC antibody increase after two immunizations with a subtype C rgp140 protein adjuvanted in GLA-AF in healthy volunteers previously immunized with HIV-DNA and HIV-MVA.


TRIAL REGISTRATION
International Clinical Trials Registry PACTR2010050002122368.
Injury and Treatment Characteristics of Sport-Specific Injuries Sustained in Interscholastic Athletics

BACKGROUND
The inclusion of clinical practice factors, beyond epidemiologic data, may help guide medical coverage and care decisions.


HYPOTHESIS
Trends in injury and treatment characteristics of sport-specific injuries sustained by secondary school athletes will differ based on sport.


STUDY DESIGN
Retrospective analysis of electronic patient records.


LEVEL OF EVIDENCE
Level 4.


METHODS
Participants consisted of 3302 boys and 2293 girls who were diagnosed with a sport-related injury or condition during the study years. Injury (sport, body part, diagnosis via ICD-9 codes) and treatment (type, amount, and duration of care) characteristics were grouped by sport and reported using summary statistics.


RESULTS
Most injuries and treatments occurred in football, girls' soccer, basketball, volleyball, and track and field. Sprain or strain of the ankle, knee, and thigh/hip/groin and concussion were the most commonly documented injuries across sports. The injury pattern for boys' wrestling differed from other sports and included sprain or strain of the elbow and neck and general medical skin conditions. The most frequently reported service was athletic training evaluation/reevaluation treatment, followed by hot/cold pack, therapeutic exercise, manual therapy techniques, electrical stimulation, and strapping of lower extremity joints. Most sports required 4 to 5 services per injury. With the exception of boys' soccer and girls' softball, duration of care ranged from 10 to 14 days. Girls' soccer and girls' and boys' track and field reported the longest durations of care.


CONCLUSION
Injury and treatment characteristics are generally comparable across sports, suggesting that secondary school athletic trainers may diagnose and treat similar injuries regardless of sport.


CLINICAL RELEVANCE
Subtle sport trends, including skin conditions associated with boys' wrestling and longer duration of care for girls' soccer, are important to note when discussing appropriate medical coverage and care.
Epidemiology of extrapulmonary tuberculosis in the United States, 1993-2006.

BACKGROUND
Almost one-fifth of United States tuberculosis cases are extrapulmonary; unexplained slower annual case count decreases have occurred in extrapulmonary tuberculosis (EPTB), compared with annual case count decreases in pulmonary tuberculosis (PTB) cases. We describe the epidemiology of EPTB by means of US national tuberculosis surveillance data.


METHODS
US tuberculosis cases reported from 1993 to 2006 were classified as either EPTB or PTB. EPTB encompassed lymphatic, pleural, bone and/or joint, genitourinary, meningeal, peritoneal, and unclassified EPTB cases. We excluded cases with concurrent extrapulmonary-pulmonary tuberculosis and cases of disseminated (miliary) tuberculosis. Demographic characteristics, drug susceptibility test results, and risk factors, including human immunodeficiency virus (HIV) status, were compared for EPTB and PTB cases.


RESULTS
Among 253,299 cases, 73.6% were PTB and 18.7% were EPTB, including lymphatic (40.4%), pleural (19.8%), bone and/or joint (11.3%), genitourinary (6.5%), meningeal (5.4%), peritoneal (4.9%), and unclassified EPTB (11.8%) cases. Compared with PTB, EPTB was associated with female sex (odds ratio [OR], 1.7; 95% confidence interval [CI], 1.7-1.8) and foreign birth (OR, 1.5; CI, 1.5-1.6), almost equally associated with HIV status (OR, 1.1; CI, 1.1-1.1), and negatively associated with multidrug resistance (OR, 0.6; CI, 0.5-0.6) and several tuberculosis risk factors, especially homelessness (OR, 0.3; CI, 0.3-0.3) and excess alcohol use (OR, 0.3; CI, 0.3-0.3). Slower annual decreases in EPTB case counts, compared with annual decreases in PTB case counts, from 1993 through 2006 have caused EPTB to increase from 15.7% of tuberculosis cases in 1993 to 21.0% in 2006.


CONCLUSIONS
EPTB epidemiology and risk factors differ from those of PTB, and the proportion of EPTB has increased from 1993 through 2006. Further study is needed to identify causes of the proportional increase in EPTB.
Apollonian circle packings : number theory

Apollonian circle packings arise by repeatedly filling the interstices between mutually tangent circles with further tangent circles. It is possible for every circle in such a packing to have integer radius of curvature, and we call such a packing an integral Apollonian circle packing. This paper studies number-theoretic properties of the set of integer curvatures appearing in such packings. Each Descartes quadruple of four tangent circles in the packing gives an integer solution to the Descartes equation, which relates the radii of curvature of four mutually tangent circles: x þ y þ z þ w 1⁄4 1 2 ðx þ y þ z þ wÞ: Each integral Apollonian circle packing is classified by a certain root quadruple of integers that satisfies the Descartes equation, and that corresponds to a particular quadruple of circles appearing in the packing. We express the number of root quadruples with fixed minimal element n as a class number, and give an exact formula for it. We study which integers occur in a given integer packing, and determine congruence restrictions which sometimes apply. We present evidence suggesting that the set of integer radii of curvatures that appear in an integral Apollonian circle packing has positive density, and in fact represents all sufficiently large integers not excluded by Corresponding author. E-mail addresses: graham@ucsd.edu (R.L. Graham), jcl@research.att.com (J.C. Lagarias), colinm@ research.avayalabs.com (C.L. Mallows), allan@research.att.com (A.R. Wilks), catherine.yan@math. tamu.edu (C.H. Yan). 1 Current address: Department of Computer Science, University of California at San Diego, La Jolla, CA 92093, USA. 2 Work partly done during a visit to the Institute for Advanced Study. 3 Current address: Avaya Labs, Basking Ridge, NJ 07920, USA. 0022-314X/03/$ see front matter r 2003 Elsevier Science (USA). All rights reserved. doi:10.1016/S0022-314X(03)00015-5 congruence conditions. Finally, we discuss asymptotic properties of the set of curvatures obtained as the packing is recursively constructed from a root quadruple. r 2003 Elsevier Science (USA). All rights reserved.
A Static Friction Model for Elastic-Plastic Contacting Rough Surfaces

A model that predicts the static friction for elastic-plastic contact of rough surface presented. The model incorporates the results of accurate finite element analyses elastic-plastic contact, adhesion and sliding inception of a single asperity in a statis representation of surface roughness. The model shows strong effect of the externa and nominal contact area on the static friction coefficient in contrast to the classical of friction. It also shows that the main dimensionless parameters affecting the s friction coefficient are the plasticity index and adhesion parameter. The effect of adh on the static friction is discussed and found to be negligible at plasticity index va larger than 2. It is shown that the classical laws of friction are a limiting case of present more general solution and are adequate only for high plasticity index and n gible adhesion. Some potential limitations of the present model are also discussed ing to possible improvements. A comparison of the present results with those obt from an approximate CEB friction model shows substantial differences, with the l severely underestimating the static friction coefficient. @DOI: 10.1115/1.1609488 #
Management and outcome of vein of Galen malformation.

OBJECTIVE
To describe our experience of treating children with vein of Galen aneurysmal malformation (VGM) in a single UK centre between 2003 and 2008.


METHOD
Retrospective review of case notes and neuroimaging.


RESULTS
33 children were seen (26 neonates, seven infants), of whom 28 underwent endovascular treatment. Four were not offered treatment as they had evidence of severe diffuse brain injury at presentation; treatment was deferred in another who subsequently died. Seven children died (two of whom had endovascular treatment). Of the survivors (all treated), 13 (39%) are neurodevelopmentally intact, seven (21%) have mild neurodevelopmental impairment and the remaining six (18%) have significant neurological impairment. The authors were not able to identify clinical or radiological parameters which strongly predicted outcome. Of note, two children with initially low Bicêtre scores were neurologically intact after successful embolisation.


CONCLUSION
The outlook for children with VGM is significantly better since the advent of endovascular treatment. Decisions about the appropriateness and timing of treatment should be taken by an experienced multidisciplinary team.