LLukas22/scidocs huggingface dataset:
Perfusion deficits detected by arterial spin-labeling in patients with TIA with negative diffusion and vascular imaging.

BACKGROUND AND PURPOSE
A substantial portion of clinically diagnosed TIA cases is imaging-negative. The purpose of the current study is to determine if arterial spin-labeling is helpful in detecting perfusion abnormalities in patients presenting clinically with TIA.


MATERIALS AND METHODS
Pseudocontinuous arterial spin-labeling with 3D background-suppressed gradient and spin-echo was acquired on 49 patients suspected of TIA within 24 hours of symptom onset. All patients were free of stroke history and had no lesion-specific findings on general MR, DWI, and MRA sequences. The calculated arterial spin-labeling CBF maps were scored from 1-3 on the basis of presence and severity of perfusion disturbance by 3 independent observers blinded to patient history. An age-matched cohort of 36 patients diagnosed with no cerebrovascular events was evaluated as a control. Interobserver agreement was assessed by use of the Kendall concordance test.


RESULTS
Scoring of perfusion abnormalities on arterial spin-labeling scans of the TIA cohort was highly concordant among the 3 observers (W = 0.812). The sensitivity and specificity of arterial spin-labeling in the diagnosis of perfusion abnormalities in TIA was 55.8% and 90.7%, respectively. In 93.3% (70/75) of the arterial spin-labeling CBF map readings with positive scores (≥2), the brain regions where perfusion abnormalities were identified by 3 observers matched with the neurologic deficits at TIA onset.


CONCLUSIONS
In this preliminary study, arterial spin-labeling showed promise in the detection of perfusion abnormalities that correlated with clinically diagnosed TIA in patients with otherwise normal neuroimaging results.
Intraoperative Assessment of Left Atrial Diverticulum and Remnant Stump after Left Atrial Appendage Epicardial Occlusion.

OBJECTIVES
Epicardial left atrial appendage (LAA) closure with use of occluder is an emerging technique. Absence of remnant LAA stump is major criterion of successful obliteration. The aim of study was to assess early success rate of epicardial LAA closure.


METHODS
Fifteen patients with persistent AF and coronary artery disease underwent off-pump coronary revascularization with concomitant ablation and LAA epicardial occlusion with use of two types of occluders. Before incision and after appendage closure, TEE was performed to assess the LAA anatomy, diameter of left atrial ridge, and remnant LAA stump after occlusion.


RESULTS
In 80% (12) of patients, formation of a left atrial diverticulum was observed with the left atrial ridge forming the superior boundary. In 5 patients (33%), a minimal remnant LAA stump was found, none exceeding 1 cm (average length: 1.5 ± 2.3 mm). In all patients, blood flow in LAA cavity distal to the occluder was absent. There was no significant difference in LAA type, average left atrial diameter, LAA orifice, LAA length, left atrial ridge, or size of occluder used between patients with and without a remnant LAA stump. Occurrence of a remnant LAA stump correlated significantly with unfavorable anatomy (LAA orifice < 20 mm and LA ridge > 5 mm; r = 0.5774, P = 0.02).


CONCLUSION
The early success of epicardial LAA occlusion is not dependent on LAA morphologic type or occluder used. A minimal remnant LAA stump not exceeding 1 cm in length without distal blood flow was observed in one-third of the cases.
Affective Factors That Influence Chemistry Achievement ( Attitude a nd Self Efficacy ) and The Power Of These Factors To Predict Chemistry Achievement -

In this research, our aim was to determine students’ level of attitude and self efficacy towards chemistry and to put forth effects of these variables on chemistry achievement for consideration (in other words, to determine how the chemistry achievement were predicted by these variables). In this point of view the research was conducted with 1000 students studying at the 1, 2 and the 3 grade of 10 high schools which are located in the city center of Mersin. Addressed to research problems, data was analyzed via descriptive, correlation, linear and multiple regression statistical analyses. As a result it is determined that 2 graders group of high schools has maximum attitude scores and the attitude towards chemistry course, on its own, is a significant predictor of chemistry achievement. it is also determined that 2 graders group of high schools has maximum self efficacy scores and the self efficacy towards chemistry course, on its own, is a significant predictor of chemistry achievement.
Longitudinal melanonychia.

BACKGROUND
Ungual melanoma is the most serious disease affecting the nail. The majority start with a longitudinal brown streak in the nail.


OBJECTIVE
To outline the different nail pigmentations, their differential diagnoses, treatment, and prognosis.


METHOD
Clinical and histologic evaluation of dark nail pigmentations.


CONCLUSION
Brown to black nail pigmentation may be due to different coloring substances of exogenous and endogenous origin. Exogenous pigmentations usually are not streaky or do not present as a stripe of even width with regular borders. Bacterial pigmentation, most commonly due to Pseudomonas aeruginosa or Proteus spp., have a greenish or grayish hue and the discoloration is often confined to the lateral edge of the nail. Subungual hematoma may result from a single heavy trauma or repeated microtrauma which often escapes notice. The latter is usually found on the medial aspect of the great toe. Although oval in shape, it commonly does not form a neat streak. Melanin pigmentation in the form of a longitudinal streak in the nail is due to a pigment-producing focus of melanocytes in the matrix. Neither the color intensity nor the age of the patient are proof of benignity or malignancy although subungual melanomas are very rare in children and malignant longitudinal melanonychia is usually wider than 5 mm. Hutchinson's melanotic whitlow, nail dystrophy, and a bleeding mass strongly suggest malignancy. Treatment is as conservative as possible in order to keep the tip of the digit; once the melanoma is completely removed, amputations have not been shown to prolong the disease-free survival time.
Female Genital Mutilation/Cutting in the United States: Updated Estimates of Women and Girls at Risk, 2012.

OBJECTIVES
In 1996, the U.S. Congress passed legislation making female genital mutilation/cutting (FGM/C) illegal in the United States. CDC published the first estimates of the number of women and girls at risk for FGM/C in 1997. Since 2012, various constituencies have again raised concerns about the practice in the United States. We updated an earlier estimate of the number of women and girls in the United States who were at risk for FGM/C or its consequences.


METHODS
We estimated the number of women and girls who were at risk for undergoing FGM/C or its consequences in 2012 by applying country-specific prevalence of FGM/C to the estimated number of women and girls living in the United States who were born in that country or who lived with a parent born in that country.


RESULTS
Approximately 513,000 women and girls in the United States were at risk for FGM/C or its consequences in 2012, which was more than three times higher than the earlier estimate, based on 1990 data. The increase in the number of women and girls younger than 18 years of age at risk for FGM/C was more than four times that of previous estimates.


CONCLUSION
The estimated increase was wholly a result of rapid growth in the number of immigrants from FGM/C-practicing countries living in the United States and not from increases in FGM/C prevalence in those countries. Scientifically valid information regarding whether women or their daughters have actually undergone FGM/C and related information that can contribute to efforts to prevent the practice in the United States and provide needed health services to women who have undergone FGM/C are needed.
Soy food consumption does not lower LDL cholesterol in either equol or nonequol producers.

BACKGROUND
Health claims link soy protein (SP) consumption, through plasma cholesterol reduction, to a decreased risk of heart disease. Soy isoflavones (ISOs), particularly in individuals who produce equol, might also contribute to lipid lowering and thus reduce SP requirements.


OBJECTIVE
The objective was to examine the contributions of SP, ISOs, and equol to the hypocholesterolemic effects of soy foods.


DESIGN
Nonsoy consumers (33 men, 58 women) with a plasma total cholesterol (TChol) concentration >5.5 mmol/L participated in a double-blind, placebo-controlled, crossover intervention trial. The subjects consumed 3 diets for 6 wk each in random order, which consisted of foods providing a daily dose of 1) 24 g SP and 70-80 mg ISOs (diet S); 2) 12 g SP, 12 g dairy protein (DP), and 70-80 mg ISOs (diet SD); and 3) 24 g DP without ISOs (diet D). Fasting plasma TChol, LDL cholesterol, HDL cholesterol, and triglycerides (TGs) were measured after each diet.


RESULTS
TChol was 3% lower with the S diet (-0.17 +/- 0.06 mmol/L; P < 0.05) than with the D diet, and TGs were 4% lower with both the S (-0.14 +/- 0.05 mmol/L; P < 0.05) and SD (-0.12 +/- 0.05 mmol/L; P < 0.05) diets. There were no significant effects on LDL cholesterol, HDL cholesterol, or the TChol:HDL cholesterol ratio. On the basis of urinary ISOs, 30 subjects were equol producers. Lipids were not affected significantly by equol production.


CONCLUSIONS
Regular consumption of foods providing 24 g SP/d from ISOs had no significant effect on plasma LDL cholesterol in mildly hypercholesterolemic subjects, regardless of equol-producing status.
MMP-2, TIMP-1, E-cadherin, and beta-catenin expression in endometrial serous carcinoma compared with low-grade endometrial endometrioid carcinoma and proliferative endometrium.

OBJECTIVE
To investigate the expression of MMP-2, TIMP-1, E-cadherin and beta-catenin in endometrial serous carcinoma (ESC), low-grade endometrial endometrioid carcinoma (EEC), and proliferative endometrium.


METHODS
We performed an immunohistochemical study on 14 cases of ESC, 15 cases of low-grade EEC, and 10 cases of proliferative endometrium.


RESULTS
Compared with low-grade EEC, ESC showed significantly increased MMP-2 and TIMP-1 expression, as well as decreased membranous beta-catenin staining. E-cadherin expression was significantly lower in ESC and EEC as compared with proliferative endometrium.


CONCLUSIONS
We suggest that MMP-2 and TIMP-1 expression and loss of beta-catenin have a role in the pathogenesis and progression of ESC. Decreased E-cadherin may have an important role in the development of both ESC and EEC. Furthermore, the dissimilarities in MMP-2, TIMP-1, E-cadherin and beta-catenin expressions in ESC compared with EEC may be responsible, along with other factors, for their different biological behavior.
A Fast Two-Dimensional Median Filtering Algorithm

Aktmcz-We present a fast algorithm for two-dimensional median fiitering. It is based on storing and updating the gray level histogram of the picture elements in the window. The algorithm is much faster than conventional sorting methods. For a window size of m X n, the computer time required is O(n).
A self-deployable origami structure with locking mechanism induced by buckling effect

One of the major problems in utilizing origami structures is ensuring variable stiffness; a deployable structure needs to become stiff or flexible according to the requirements of its use in an application. In this study, we present a self-deploying tubular origami mechanism that switches between two distinctive states: small and flexible at its normal state and rigid and stiffened at a locked state. By embedding compact torsional SMA actuators into the mechanism in a novel way through stitching, the process of deploying from the normal to the locked state proceeds in a simple and low-profile manner. With global heating, the torsional SMA wires activate a buckling effect that draws a radical change of folding line from one diagonal to another in every unit tile of the tube, creating axial stiffness. The activated structure, which weighs only 2.9 g, can endure a load of 2.7 kg or more. Additionally, since it does not require bulky actuators, this origami structure can be highly mobile and small in size. This novel origami mechanism is expected to be useful in a wide variety of applications, such as aerospace equipment, mobile architecture, and medical devices, especially those used in minimally invasive surgery (MIS).
Blechnum Orientale Linn - a fern with potential as antioxidant, anticancer and antibacterial agent

BACKGROUND
Blechnum orientale Linn. (Blechnaceae) is used ethnomedicinally for the treatment of various skin diseases, stomach pain, urinary bladder complaints and sterilization of women. The aim of the study was to evaluate antioxidant, anticancer and antibacterial activity of five solvent fractions obtained from the methanol extract of the leaves of Blechnum orientale Linn.


METHODS
Five solvent fractions were obtained from the methanol extract of B. orientale through successive partitioning with petroleum ether, chloroform, ethyl acetate, butanol and water. Total phenolic content was assessed using Folin-Ciocalteu's method. The antioxidant activity was determined by measuring the scavenging activity of DPPH radicals. Cytotoxic activity was tested against four cancer cell lines and a non-malignant cell using MTT assay. Antibacterial activity was assessed using the disc diffusion and broth microdilution assays. Standard phytochemical screening tests for saponins, tannins, terpenoids, flavonoids and alkaloids were also conducted.


RESULTS
The ethyl acetate, butanol and water fractions possessed strong radical scavenging activity (IC50 8.6-13.0 microg/ml) and cytotoxic activity towards human colon cancer cell HT-29 (IC50 27.5-42.8 microg/ml). The three extracts were also effective against all Gram-positive bacteria tested: Bacillus cereus, Micrococcus luteus, methicillin-susceptible Staphylococcus aureus (MSSA), methicillin-resistant Staphylococcus aureus (MRSA) and Stapylococcus epidermidis(minimum inhibitory concentration MIC 15.6-250 mug/ml; minimum bactericidal concentration MBC 15.6-250 microg/ml). Phytochemical analysis revealed the presence of flavonoids, terpenoids and tannins. Ethyl acetate and butanol fractions showed highest total phenolic content (675-804 mg gallic acid equivalent/g).


CONCLUSIONS
The results indicate that this fern is a potential candidate to be used as an antioxidant agent, for colon cancer therapy and for treatment of MRSA infections and other MSSA/Gram-positive bacterial infectious diseases.
Genome-wide association study of toxic metals and trace elements reveals novel associations

The accumulation of toxic metals in the human body is influenced by exposure and mechanisms involved in metabolism, some of which may be under genetic control. This is the first genome-wide association study to investigate variants associated with whole blood levels of a range of toxic metals. Eleven toxic metals and trace elements (aluminium, cadmium, cobalt, copper, chromium, mercury, manganese, molybdenum, nickel, lead and zinc) were assayed in a cohort of 949 individuals using mass spectrometry. DNA samples were genotyped on the Infinium Omni Express bead microarray and imputed up to reference panels from the 1000 Genomes Project. Analyses revealed two regions associated with manganese level at genome-wide significance, mapping to 4q24 and 1q41. The lead single nucleotide polymorphism (SNP) in the 4q24 locus was rs13107325 (P-value = 5.1 × 10(-11), β = -0.77), located in an exon of SLC39A8, which encodes a protein involved in manganese and zinc transport. The lead SNP in the 1q41 locus is rs1776029 (P-value = 2.2 × 10(-14), β = -0.46). The SNP lies within the intronic region of SLC30A10, another transporter protein. Among other metals, the loci 6q14.1 and 3q26.32 were associated with cadmium and mercury levels (P = 1.4 × 10(-10), β = -1.2 and P = 1.8 × 10(-9), β = -1.8, respectively). Whole blood measurements of toxic metals are associated with genetic variants in metal transporter genes and others. This is relevant in inferring metabolic pathways of metals and identifying subsets of individuals who may be more susceptible to metal toxicity.
A comparison of microbial growth in alfaxalone, propofol and thiopental.

OBJECTIVES
To compare the growth of Staphylococcus aureus and Escherichia coli in alfaxalone with that in propofol and thiopental and to evaluate contaminant microbial growth in these agents under two different conditions of storage and handling.


METHODS
Known quanta of S aureus and E coli were inoculated into separate 5 ml samples of propofol, thiopental and alfaxalone. Quantitative bacterial analysis was performed at intervals over a 14 day period. Commercial preparations of propofol, thiopental and alfaxalone were stored and handled using "dirty" or "clean" techniques. Microbial quantification and identification was performed over a 14 day period.


RESULTS
S aureus and E coli grew rapidly in propofol after six hours. Both bacteria were killed by thiopental. S aureus numbers slowly declined in alfaxalone; E coli growth was rapid after 24 hours. In "dirty" and "clean" groups of intravenous anaesthetics, 9.3 and 7.4 per cent of samples, respectively, were positive for microbial growth; none were considered to represent colonisation of bottles.


CLINICAL SIGNIFICANCE
Alfaxalone supports growth of some microorganisms but less readily than propofol. Bacterial colonisation of intravenous anaesthetic bottles is uncommon, but contamination as syringes are prepared for injection occurs regardless of storage and handling technique.
Visual cue training to improve walking and turning after stroke: a study protocol for a multi-centre, single blind randomised pilot trial

BACKGROUND
Visual information comprises one of the most salient sources of information used to control walking and the dependence on vision to maintain dynamic stability increases following a stroke. We hypothesize, therefore, that rehabilitation efforts incorporating visual cues may be effective in triggering recovery and adaptability of gait following stroke. This feasibility trial aims to estimate probable recruitment rate, effect size, treatment adherence and response to gait training with visual cues in contrast to conventional overground walking practice following stroke.


METHODS/DESIGN
A 3-arm, parallel group, multi-centre, single blind, randomised control feasibility trial will compare overground visual cue training (O-VCT), treadmill visual cue training (T-VCT), and usual care (UC). Participants (n = 60) will be randomly assigned to one of three treatments by a central randomisation centre using computer generated tables to allocate treatment groups. The research assessor will remain blind to allocation. Treatment, delivered by physiotherapists, will be twice weekly for 8 weeks at participating outpatient hospital sites for the O-VCT or UC and in a University setting for T-VCT participants.Individuals with gait impairment due to stroke, with restricted community ambulation (gait speed <0.8m/s), residual lower limb paresis and who are able to take part in repetitive walking practice involving visual cues (i.e., no severe visual impairments, able to walk with minimal assistance and no comorbid medical contraindications for walking practice) will be included.The primary outcomes concerning participant enrolment, recruitment, retention, and health and social care resource use data will be recorded over a recruitment period of 18 months. Secondary outcome measures will be undertaken before randomisation (baseline), after the eight-week intervention (outcome), and at three months (follow-up). Outcome measures will include gait speed and step length symmetry; time and steps taken to complete a 180° turn; assessment of gait adaptability (success rate in target stepping); timed up and go; Fugl-Meyer lower limb motor assessment; Berg balance scale; falls efficacy scale; SF-12; and functional ambulation category.


DISCUSSION
Participation and compliance measured by treatment logs, accrual rate, attrition, and response variation will determine sample sizes for an early phase randomised controlled trial and indicate whether a definitive late phase efficacy trial is justified.


TRIAL REGISTRATION
Clinicaltrials.gov, NCT01600391.
Credit Card Default Predictive Modeling

Background: Predicting credit card payment default is critical for the successful business model of a credit card company. An accurate predictive model can help the company identify customers who might default their payment in the future so that the company can get involved earlier to manage risk and reduce loss. It is even better if a model can assist the company on credit card application approval to minimize the risk at upfront. However, credit card default prediction is never an easy task. It is dynamic. A customer who paid his/her payment on time in the last few months may suddenly default his/her next payment. It is also unbalanced given the fact that default payment is rare compared to non-default payments. Unbalanced dataset will easily fail using most machine learning techniques if the dataset is not treated properly.
Circuit analysis and optimization driven by worst-case distances

AbsbW-In this paper, a new methodology for integrated circuit design considering the inevitable manufacturing and operating tolerances is presented. It is based on a new concept for specification analysis that provides exact worst-case transistor model parameters and exact worst-case operating conditions. Corresponding worst-case distances provide a key measure for the performance, the yield, and the robustness of a circuit. A new deterministic method for parametric circuit design that is based on worst-case distances is presented: It comprises nominal design, worst-case analysis, yield optimization, and design centering. In contrast to current approaches, it uses standard circuit simulators and at the same time considers deterministic design parameters of integrated circuits at reasonable computational costs. The most serious disadvantage of geometric approaches to design centering is eliminated, as the method's complexity increases only linearly with the number of design variables.