LLukas22/scidocs huggingface dataset:
Tomato ABSCISIC ACID STRESS RIPENING (ASR) Gene Family Revisited

Tomato ABSCISIC ACID RIPENING 1 (ASR1) was the first cloned plant ASR gene. ASR orthologs were then cloned from a large number of monocot, dicot and gymnosperm plants, where they are mostly involved in response to abiotic (drought and salinity) stress and fruit ripening. The tomato genome encodes five ASR genes: ASR1, 2, 3 and 5 encode low-molecular-weight proteins (ca. 110 amino acid residues each), whereas ASR4 encodes a 297-residue polypeptide. Information on the expression of the tomato ASR gene family is scarce. We used quantitative RT-PCR to assay the expression of this gene family in plant development and in response to salt and osmotic stresses. ASR1 and ASR4 were the main expressed genes in all tested organs and conditions, whereas ASR2 and ASR3/5 expression was two to three orders of magnitude lower (with the exception of cotyledons). ASR1 is expressed in all plant tissues tested whereas ASR4 expression is limited to photosynthetic organs and stamens. Essentially, ASR1 accounted for most of ASR gene expression in roots, stems and fruits at all developmental stages, whereas ASR4 was the major gene expressed in cotyledons and young and fully developed leaves. Both ASR1 and ASR4 were expressed in flower organs, with ASR1 expression dominating in stamens and pistils, ASR4 in sepals and petals. Steady-state levels of ASR1 and ASR4 were upregulated in plant vegetative organs following exposure to salt stress, osmotic stress or the plant abiotic stress hormone abscisic acid (ABA). Tomato plants overexpressing ASR1 displayed enhanced survival rates under conditions of water stress, whereas ASR1-antisense plants displayed marginal hypersensitivity to water withholding.
Imatinib is effective in children with previously untreated chronic myelogenous leukemia in early chronic phase: results of the French national phase IV trial.

PURPOSE
Imatinib is the standard of care in adults with chronic myeloid leukemia (CML) in chronic phase (CP). Only a few studies to assess efficacy in children have been performed. We report on the results of the French prospective trial (ClinicalTrials.gov identifier NCT00845221) conducted in children and adolescents with newly diagnosed CML in CP.


PATIENTS AND METHODS
A total of 44 patients from age 10 months to 17 years with newly diagnosed CML in CP received daily imatinib 260 mg/m(2). Progression-free survival, responses, and tolerance were evaluated.


RESULTS
With a median follow-up times of 31 months (range, 11 to 64 months), the estimated progression-free survival rate at 36 months was 98% (95% CI, 85% to 100%). A complete hematologic response was achieved in 98% of the patients. The rates of complete cytogenetic response (CCyR) and major molecular response (MMR) were 61% and 31% at 12 months, respectively. During follow-up, CCyR and MMR were achieved in 36 children (77%) and 25 children (57%), respectively. Overall, 30% of the patients discontinued imatinib, mainly because of unsatisfactory response. The most common adverse events were neutropenia and musculoskeletal events.


CONCLUSION
Imatinib is effective in children with CML in CP with response rates similar to rates reported in adults. The adverse effects are acceptable, but longer follow-up studies are required to fully assess the long-term impact.
Development of Postural Adjustments During Reaching in Preterm Infants

Preterm infants often show postural abnormalities, such as hyperextension of neck and trunk, which can interfere with motor and cognitive development. Little is, however, known on the pathophysiology of postural development in preterm infants. Therefore, we longitudinally studied the development of postural adjustments during reaching movements in 12 preterm infants between the (corrected) ages of 4 and 18 mo. Five infants showed minor neurological dysfunctions at 18 mo, such as a mild diffuse hypotonia, a mild hypertonia of the legs, or a mild asymmetry in posture and motility, and seven infants were neurologically normal. Each assessment consisted of a simultaneous recording of video-data and surface electromyograms of arm, neck, trunk, and leg muscles during reaching in various lying and sitting positions. Comparable data on postural development in ten fullterm infants were available. The preterm infants showed an excessive amount of postural activity during reaching movements at all ages studied. Moreover, the postural adjustments were temporally disorganized and could not be modulated with respect to the velocity of the arm movement and the initial sitting position. We hypothesized that the preterms' disability to modulate their postural adjustments might be due to a reduced capacity to learn from prior experience. In our small group the postural dysfunction were not related to the presence of hyperextension at early ages, to the neurological outcome at 18 mo, or to the lesions found on the neonatal brain ultrasound scans.
Low-dose topiramate in alcohol dependence: a single-blind, placebo-controlled study.

INTRODUCTION
Topiramate (TOP) and anticonvulsants in general are considered safe and effective drugs for the treatment of alcohol dependence, even though TOP-induced adverse events are quite common, especially for high initial doses or if titration to 300 mg/d is too rapid. The aim of the present study was to assess the efficacy and tolerability profile of low-dose TOP for relapse prevention.


METHODS
After detoxification, 52 patients were randomized into 2 groups as follows: 26 patients received 100 mg of TOP (oral, twice daily), titrated over 2 weeks, and 26 patients received placebo (PLA). Both groups underwent rehabilitation twice a week.


RESULTS
After 6 weeks of treatment, compared with the PLA group, patients receiving TOP showed the following: (1) fewer drinking days (P < 0.05); (2) less daily alcohol consumption (P < 0.05); (3) more days of treatment (P < 0.05); (4) reduced levels of craving (Obsessive-Compulsive Drinking Scale) and withdrawal symptoms (Clinical Institute Withdrawal Assessment for Alcohol-Revised); and (5) improvement of anxiety, depression, and obsessive-compulsive symptom severity (Symptom Check List 90 Revised).


CONCLUSIONS
Despite the small sample size and the short follow-up period, the present PLA-controlled study demonstrated the potential usefulness of TOP, even when administered at a dosage of 100 mg/d, for the treatment of detoxified alcohol-dependent subjects, confirming results from previous studies testing higher doses of TOP.
Soft-Switching DC–DC Converter for Distributed Energy Sources With High Step-Up Voltage Capability

This paper presents high step-up dc-to-dc converter for low voltage sources such as solar photovoltaics, fuel cells, and battery banks. To achieve high voltage gain without large duty cycle operation, combination of coupled inductor and switched capacitor voltage doubler cells are used. By incorporating active clamp circuit, voltage spike due to the leakage inductance of the coupled inductor is alleviated and zero-voltage switching turn on of the main and auxiliary switch is obtained. Due to the use of MOSFETs of low voltage rating and soft turn on of the switches, conduction loss and switching losses are reduced. This improves the efficiency and power density of the converter. The proposed converter can achieve high voltage gain with reduced voltage stress on MOSFET switches and output diodes. Design and analysis of the proposed converter is carried out, and finally, a 500-W experimental prototype is built to verify theoretical analysis.
Lean tools and methods to support efficient knowledge creation

Continuous innovation is a key ingredient in maintaining a competitive advantage in the current dynamic and demanding marketplace. It requires an organization to regularly update and create knowledge for the current generation, and reuse it later for the next generation of a product. In this regard, an integrated dynamic knowledge model is targeted to structurally define a practical knowledge creation process in the product development domain. This model primarily consists of three distinct elements; SECI (socialization–externalization–combination–internalization) modes, ‘ba’, and knowledge assets. The model involves tacit knowledge and explicit knowledge interplay in ‘ba’ to generate new knowledge during the four SECI modes and update the knowledge assets. It is believed that lean tools and methods can also promote learning and knowledge creation. Therefore, a set of ten lean tools and methods is proposed in order to support and improve the efficiency of the knowledge creation process. The approach first establishes a framework to create knowledge in the product development environment, and then systematically demonstrates how these ten lean tools and methods conceptually fit into and play a significant role in that process. Following this, each of them is analyzed and appropriately positioned in a SECI mode depending on best fit. The merits of each tool/method are discussed from the perspective of selecting the individual mode. The managerial implication is that correct and quick knowledge creation can result in faster development and improved quality of products. © 2014 Elsevier Ltd. All rights reserved.
Development and preliminary validation of the cancer family impact scale for colorectal cancer.

AIM
The aim of our study was to develop a measure of how a family history of colorectal cancer (CRC) affects families from the viewpoint of unaffected family members.


METHOD
Using data from 1,285 participants (637 families) in the Johns Hopkins Colon Cancer Genetic Testing study, we developed and validated The Cancer Family Impact Scale (CFIS), an instrument for use in studies investigating relationships among family factors and CRC prevention behaviors when family history is a risk factor.


RESULTS
Through exploratory factor analysis (EFA) using a 50% random sample of participants, we identified 5 latent constructs among 18 items: (1) NEGATIVE: negative effects of cancer on the family; (2) POSITIVE: positive effects of cancer on the family; (3) COMMUNICATE: how families communicate about cancer; (4) FLOW: how information about cancer is conveyed in families; and (5) NORM: how individuals react to family norms about cancer. Confirmatory factor analysis (CFA) on the same sample showed the CFIS to have a reasonably good fit (chi(2) = 389.97, degree of freedom (df ) = 122, root mean square error of approximation = 0.06 [0.05-0.07], comparative fit index = 0.90, Tucker-Lewis index = 0.88, goodness of fit index = 0.94), and findings were cross-validated on the remaining 50% of the participants. The reliability of the scale was alpha = 0.65.


CONCLUSIONS
The CFIS could be used to clarify the role that family factors play in the association between CRC family history and CRC prevention behaviors, and also aid in the development and evaluation of family-based cancer prevention interventions.
Toward developing a systematic approach to generate benchmark datasets for intrusion detection

In network intrusion detection, anomaly-based approaches in particular suffer from accurate evaluation, comparison, and deployment which originates from the scarcity of adequate datasets. Many such datasets are internal and cannot be shared due to privacy issues, others are heavily anonymized and do not reflect current trends, or they lack certain statistical characteristics. These deficiencies are primarily the reasons why a perfect dataset is yet to exist. Thus, researchers must resort to datasets that are often suboptimal. As network behaviors and patterns change and intrusions evolve, it has very much become necessary to move away from static and one-time datasets toward more dynamically generated datasets which not only reflect the traffic compositions and intrusions of that time, but are also modifiable, extensible, and reproducible. In this paper, a systematic approach to generate the required datasets is introduced to address this need. The underlying notion is based on the concept of profiles which contain detailed descriptions of intrusions and abstract distribution models for applications, protocols, or lower level network entities. Real traces are analyzed to create profiles for agents that generate real traffic for HTTP, SMTP, SSH, IMAP, POP3, and FTP. In this regard, a set of guidelines is established to outline valid datasets, which set the basis for generating profiles. These guidelines are vital for the effectiveness of the dataset in terms of realism, evaluation capabilities, total capture, completeness, and malicious activity. The profiles are then employed in an experiment to generate the desirable dataset in a testbed environment. Various multi-stage attacks scenarios were subsequently carried out to supply the anomalous portion of the dataset. The intent for this dataset is to assist various researchers in acquiring datasets of this kind for testing, evaluation, and comparison purposes, through sharing the generated datasets and profiles. a 2011 Elsevier Ltd. All rights reserved.
Population-based tobacco treatment: study design of a randomized controlled trial

BACKGROUND
Most smokers do not receive comprehensive, evidence-based treatment for tobacco use that includes intensive behavioral counseling along with pharmacotherapy. Further, the use of proven, tobacco treatments is lower among minorities than among Whites. The primary objectives of this study are to: (1) Assess the effect of a proactive care intervention (PRO) on population-level smoking abstinence rates (i.e., abstinence among all smokers including those who use and do not utilize treatment) and on utilization of tobacco treatment compared to reactive/usual care (UC) among a diverse population of smokers, (2) Compare the effect of PRO on population-level smoking abstinence rates and utilization of tobacco treatments between African American and White smokers, and (3) Determine the cost-effectiveness of the proactive care intervention.


METHODS/DESIGN
This prospective randomized controlled trial identifies a population-based sample of current smokers from the Department of Veterans Affairs (VA) electronic medical record health factor dataset. The proactive care intervention combines: (1) proactive outreach and (2) offer of choice of smoking cessation services (telephone or face-to-face). Proactive outreach includes mailed invitation materials followed by an outreach call that encourages smokers to seek treatment with choice of services. Proactive care participants who choose telephone care receive VA telephone counseling and access to pharmacotherapy. Proactive care participants who choose face-to-face care are referred to their VA facility's smoking cessation clinic. Usual care participants have access to standard smoking cessation services from their VA facility (e.g., pharmacotherapy, smoking cessation clinic) and from their state telephone quitline. Baseline data is collected from VA administrative databases and participant surveys. Outcomes from both groups are collected 12 months post-randomization from participant surveys and from VA administrative databases. The primary outcome is self-reported smoking abstinence, which is assessed at the population-level (i.e., among those who utilize and those who do not utilize tobacco treatment). Primary analyses will follow intention-to-treat methodology.


DISCUSSION
This randomized trial is testing proactive outreach strategies offering choice of smoking cessation services, an innovation that if proven effective and cost-effective, will transform the way tobacco treatment is delivered. National dissemination of proactive treatment strategies could dramatically reduce tobacco-related morbidity, mortality, and health care costs.


CLINICAL TRIALS REGISTRATION
ClinicalTrials.gov: NCT00608426.
Endo-laparoscopic approach versus conventional open surgery in the treatment of obstructing left-sided colon cancer: long-term follow-up of a randomized trial.

INTRODUCTION
We previously conducted a randomized trial comparing the endo-laparoscopic approach (i.e. placing self-expanding metallic stents followed by laparoscopic resection) and conventional open surgery in the treatment of obstructing left-sided colon cancer. This study is a follow-up of the previous randomized trial and aims to report the long-term outcomes of the two groups.


METHODS
Forty-eight patients from the randomized trial were followed up in an outpatient clinic with regular monitoring. Patients were compared for clinicopathological variables, disease recurrence and survival rates.


RESULTS
Clinicopathological details were comparable between the two groups. During the median follow-up periods of 32 months for the open group and 65 months endo-laparoscopic group, no statistically significant difference was observed between the groups in disease recurrence rate, 5-year overall survival (27% vs 48%, P = 0.076) and 5-year disease-free survival rates (48% vs 52%, P = 0.63).


CONCLUSION
Besides being a safe bridge to subsequent elective laparoscopic surgery, preoperative self-expanding metallic stents insertion does not adversely affect oncological outcomes and patient survival. Based on our data, the endo-laparoscopic approach is the treatment of choice for patients presenting with malignant left-sided colonic obstruction.
Performance Comparison of Distance Protection Schemes for Shunt-FACTS Compensated Transmission Lines

This paper presents a comparative study of the performance of distance relays for transmission lines compensated by shunt connected flexible ac transmission system (FACTS) controllers/devices. The objective of this study is to evaluate the performance of various distance protection schemes on transmission lines with shunt-FACTS devices applied for midpoint voltage control. The impact of two types of shunt FACTS devices, static var compensator (SVC) and static synchronous compensator (STATCOM) on the transmission line distance protection schemes is studied for different fault types, fault locations and system conditions. The power system elements and the shunt-FACTS devices with their associated controllers are modeled using RSCAD/RTDS software. The results are based on the performance of commercial distance relays using a real time digital simulator (RTDS).
Controlling aggregate interference under adjacent channel interference constraint in TV white space

TV White space, where secondary systems can be deployed inside the TV coverage area and utilize the geographically unoccupied TV channels, is considered as a promising solution to relieve the spectrum shortage. To utilize this spectrum, the secondary users must ensure the protection of TV reception from harmful interference on both co-channel and adjacent channels. In this paper, we propose an analytical approach to determining the permissible transmit power for short-range secondary users under aggregate adjacent channel interference constraint in TV white space. This approach employs statistical interference modeling which considers random deployment of secondary users, antenna gain pattern, shadow fading, and the cumulative effect of interference from multiple adjacent channels. Numerical results show that the proposed scheme permits significantly higher transmit power than the existing deterministic method does, while at the same time, it keeps the required level of TV protection. Therefore, considerable potential for the short-range secondary access to TV white space is expected with our approach.
Understanding Career Choices of Men in Elementary Education

Abstract This study was a component of a program of research designed to increase understanding of the career choices of men who select nontraditional careers, such as elementary education, by comparing what they find important in their careers, their sex role identity, and personality components with men in a traditional career and with women in elementary education. Participants completed the Important Components of a Career scale, Bem's Sex Role Inventory (short form), and Cattell's 16 Personality Factor measure. The questionnaire packets were mailed to 1,000 potential respondents in five groups, with a response rate of 46%. The men in elementary education and nursing valued relationship-oriented components of their careers significantly more than did the men in engineering, F(2, 233) = 35.39, p < .01, Men differed significantly from women in elementary education in their personality profiles, Hotelling's T = .37, F(15, 135) = 3.32, p < .01, specifically with respect to tough versus tender mindedness, ...
Layer-Wise Relevance Propagation for Neural Networks with Local Renormalization Layers

Layer-wise relevance propagation is a framework which allows to decompose the prediction of a deep neural network computed over a sample, e.g. an image, down to relevance scores for the single input dimensions of the sample such as subpixels of an image. While this approach can be applied directly to generalized linear mappings, product type non-linearities are not covered. This paper proposes an approach to extend layer-wise relevance propagation to neural networks with local renormalization layers, which is a very common product-type non-linearity in convolutional neural networks. We evaluate the proposed method for local renormalization layers on the CIFAR-10, Imagenet and MIT Places datasets.
The nature and frequency of bisphosphonate-associated osteonecrosis of the jaws in dental implant patients: a South Australian case series.

PURPOSE
To determine the number of bisphosphonate-associated cases of dental implant failure in South Australia.


MATERIALS AND METHODS
All general and specialist dentists who place dental implants in South Australia were contacted and asked to provide information on the total number of implants placed over the decade to December 2007. Cases of bisphosphonate-associated implant failure were identified.


RESULTS
All 46 practitioners involved in implant placement and the management of bisphosphonate-associated osteonecrosis of the jaws in South Australia were identified. Approximately 28,000 implants had been placed in 16,000 patients. We identified 7 cases of oral bisphosphonate-associated implant failure, with 3 cases of failure of osseointegration and 4 cases of successful implants losing integration after being placed on oral bisphosphonates. There were 5 women and 2 men, and the mean age was 65.7 years (range, 49-75 years). Only 1 was medically compromised, with steroids and diabetes. No cases of implant failure in intravenous bisphosphonate cases were identified. On the basis of the assumption that 5% of the patients were taking an oral bisphosphonate, 1 in 114 (0.89%) had implant failure.


CONCLUSION
In patients taking oral bisphosphonates, a failure to integrate or subsequent loss of integration may occur when oral bisphosphonates are started after successful implant placement. The rate of failure is low, at less than 1%.