LLukas22/scidocs huggingface dataset:
Breast cancer screening practices and awareness in women admitted to a tertiary care hospital of Lahore, Pakistan.

OBJECTIVE
To assess the awareness and practices of women with regard to breast cancer and its different methods of screening.


METHODS
A descriptive cross-sectional study was carried out in the inpatient wards of Fatima Memorial Hospital, Lahore. By convenience sampling, 200 female inpatients were selected. An interviewer based pre-tested questionnaire was used to ask questions regarding knowledge and practices about breast self-examination, clinical breast examination, and mammography.


RESULTS
A total of 189 patients gave consent to be interviewed. One hundred and sixty one (84%) patients had heard of breast cancer, 35% were aware of one or two major risk factors while 65% knew at least one major sign or symptom of breast cancer. Eighty five percent of respondents believed that early detection of cancer improved survival. Of the 101 participants > 40 years of age, 36.9% practiced Breast Self Examination, 6.9% Clinical Breast Examination and only 4.9% had had a mammogram at some point in their life. Most patients did not practice breast cancer screening because they had either never heard of the screening tests, or did not feel the need to perform them.


CONCLUSIONS
The results of this study revealed lack of awareness regarding breast cancer and its screening practices. Most women did not practice breast cancer screening. Increased awareness should be made through health education and doctors' encouragement of BSE, CBE and Mammography practice.
RaptorX-Property: a web server for protein structure property prediction

RaptorX Property (http://raptorx2.uchicago.edu/StructurePropertyPred/predict/) is a web server predicting structure property of a protein sequence without using any templates. It outperforms other servers, especially for proteins without close homologs in PDB or with very sparse sequence profile (i.e. carries little evolutionary information). This server employs a powerful in-house deep learning model DeepCNF (Deep Convolutional Neural Fields) to predict secondary structure (SS), solvent accessibility (ACC) and disorder regions (DISO). DeepCNF not only models complex sequence-structure relationship by a deep hierarchical architecture, but also interdependency between adjacent property labels. Our experimental results show that, tested on CASP10, CASP11 and the other benchmarks, this server can obtain ∼84% Q3 accuracy for 3-state SS, ∼72% Q8 accuracy for 8-state SS, ∼66% Q3 accuracy for 3-state solvent accessibility, and ∼0.89 area under the ROC curve (AUC) for disorder prediction.
Mining spatio-temporal information on microblogging streams using a density-based online clustering method

0957-4174/$ see front matter 2012 Elsevier Ltd. A doi:10.1016/j.eswa.2012.02.136 E-mail address: leechung@mail.ee.kuas.edu.tw Social networks have been regarded as a timely and cost-effective source of spatio-temporal information for many fields of application. However, while some research groups have successfully developed topic detection methods from the text streams for a while, and even some popular microblogging services such as Twitter did provide information of top trending topics for selection, it is still unable to fully support users for picking up all of the real-time event topics with a comprehensive spatio-temporal viewpoint to satisfy their information needs. This paper aims to investigate how microblogging social networks (i.e. Twitter) can be used as a reliable information source of emerging events by extracting their spatio-temporal features from the messages to enhance event awareness. In this work, we applied a density-based online clustering method for mining microblogging text streams, in order to obtain temporal and geospatial features of real-world events. By analyzing the events detected by our system, the temporal and spatial impacts of the emerging events can be estimated, for achieving the goals of situational awareness and risk management. 2012 Elsevier Ltd. All rights reserved.
Sleep and neurodegenerative diseases.

Sleep disturbances are common in neurodegenerative diseases. Disturbed sleep can result in fatigue, irritability, morning headaches, impaired motor and cognitive skills, depression, and daytime somnolence. The major sleep complaints include insomnia, hypersomnia, parasomnia, excessive nocturnal motor activity, circadian sleep-wake rhythm disturbance, and respiratory dysrhythmia. The pathogenetic mechanisms of sleep disturbances may be secondary to direct structural alteration of the sleep-wake generating neurons or from several other indirect mechanisms. At the biochemical level, neurodegenerative diseases may be largely classified as tauopathies, alpha-synucleinopathies, and other diseases. Overnight polysomnography (PSG), Multiple Sleep Latency Test, Maintenance of Wakefulness Test, and actigraphy are some important diagnostic laboratory tests in the evaluation of sleep disturbances. Management of sleep disturbances is complex and is based primarily on the nature of the sleep disturbance. The clinical profiles, pathogenetic mechanisms, PSG findings, and management issues are discussed here with reference to some common neurodegenerative diseases.
Effects of milnacipran on the multidimensional aspects of fatigue and the relationship of fatigue to pain and function: pooled analysis of 3 fibromyalgia trials.

BACKGROUND
Fatigue is a core symptom in fibromyalgia that can negatively affect a patient's quality of life.


OBJECTIVE
The objective of this study was to analyze fatigue-related data from 3 randomized, placebo-controlled trials of milnacipran (n = 3109) in fibromyalgia patients.


METHODS
Fatigue was assessed with the Multidimensional Fatigue Inventory (MFI). Treatment effects were evaluated by changes in MFI total scores and identifying patients with improvement of 30% or greater from baseline. Path analyses were conducted to evaluate direct and indirect effects of treatment on fatigue.


RESULTS
Patients had high levels of baseline fatigue; mean MFI total score was 68.1 (of 100). After 3 months of stable-dose treatment, patients receiving milnacipran 100 and/or 200 mg/d had significant improvement in MFI total and subscale scores (P < 0.05 vs placebo). The largest treatment effect was found in patients with equal to or greater than 20% to 40% fatigue improvement. Significantly more patients met the threshold of 30% or greater with milnacipran (100 mg/d, 17.6%; 200 mg/d, 15.2%) than with placebo (9.9%); odds ratios for this responder status were 1.93 and 1.63, respectively (P < 0.05 for both doses). Path analyses indicated that up to 28% of fatigue improvement may be attributed to direct milnacipran effects (ie, not indirectly through effects on pain or other symptoms).


CONCLUSIONS
Fibromyalgia patients in the milnacipran studies had high levels of baseline fatigue. Patients receiving milnacipran had statistically significant and clinically meaningful reductions in fatigue that were not completely attributable to indirect treatment effects through pain reduction. Evaluating and managing fatigue are an important clinical concern when treating patients with fibromyalgia.
Labour Market Flexibility and Employment Protection Regulation in the Baltic States

Labour Market Flexibility and Employment Protection Regulation in the Baltic States There is increasing pressure for the flexibility of labour markets both in current EU member states and candidate countries. The paper aims to estimate the strictness of employment protection regulation, one of the most relevant aspects of labour market flexibility, and the degree of its actual enforcement, for the Baltic States. For the studies on CEE labour markets the novelty in our approach is that we use information from the applicable legislation as well as on the coverage of labour legislation and the practice of law enforcement. The analysis shows that, though overall EPL strictness is close to the average of EU countries, individual and collective dismissals are relatively heavily and temporary forms of employment relatively weakly regulated. Still, the effective flexibility is increased by larger share of less protected workers and problems with law enforcement, which may be the reason why employers’ estimates on the flexibility differ somewhat from the flexibility of formal legislation. The employment protection legislation seems not to have influenced the level of unemployment in the sample of CEE countries. However, it is possible that labour markets of Baltic States will become more rigid if the law enforcement improves, with possible adverse effects on labour market performance. JEL Classification: J23, J32, J8, K31
Home-based telemonitored Nordic walking training is well accepted, safe, effective and has high adherence among heart failure patients, including those with cardiovascular implantable electronic devices: a randomised controlled study.

BACKGROUND
The benefits of rehabilitation in heart failure (HF) patients are well established. Little is known about Nordic walking (NW) training in HF patients especially in those with cardiovascular implantable electronic devices (CIEDs).


PURPOSE
The purpose of this study was to assess safety, effectiveness, adherence to and acceptance of home-based telemonitored NW in HF patients, including those with CIEDs (i.e. cardiac resynchronisation therapy, implantable cardioverter-defibrillator).


METHODS
The study design was a single-centre, prospective, parallel-group, randomised (2:1), controlled trial among 111 HF patients, New York Heart Association (NYHA) II-III; left ventricular ejection fraction (EF) ≤ 40%. The intervention was a home-based telemonitored eight-week NW (training group (TG) n = 77) five times weekly vs usual care alone (control group (CG) n = 34). Outcome measures included a primary end point of functional capacity assessed by peak oxygen consumption (VO2peak). Secondary end points included: workload duration (t) in cardiopulmonary exercise test (CPET), six-minute walking test (6-MWT) distance and quality of life (QoL), Medical Outcome Survey Short Form 36 (SF-36); safety; adherence to and acceptance of NW. Measurements were made before and after intervention.


RESULTS
NW resulted in significant improvement in: VO2peak (16.1 ± 4.0 vs 18.4 ± 4.1(ml/kg/min), p = 0.0001), t (471 ± 141 vs 577 ± 158 (s), p = 0.0001), 6-MWT(428 ± 93 vs 480 ± 87 (m), p = 0.0001) and QoL (79.0 ± 31.3 vs 70.8 ± 30.3 (score), p = 0.0001). We did not observe favourable results in the CG. The differences between the TG and CG were significant in: ΔVO2peak (Δ2.0 ± 2.4 vs Δ-0.2 ± 2.1, p = 0.0004); Δt (Δ108 ± 108 vs Δ0.94 ± 109, p = 0.0031); Δ6-MWT (Δ53.8 ± 63.9 vs Δ22.0 ± 68.7, p = 0.0483). In neither group were there deaths nor necessity for hospitalisation. We did not observe any intervention from CIEDs during NW. All patients in the TG completed rehabilitation and accepted it well.


CONCLUSION
In HF patients, including those with CIEDs, home-based telemonitored NW is safe and effective. NW was well accepted by patients and adherence was high and promising.
Blockade of insulin sensitive steady-state R-type Ca<Superscript>2</Superscript> channel by PN 200-110 in heart and vascular smooth muscle

The effect of high K-concentration, insulin and the L-type Ca 2+ channel blocker PN 200-110 on cytosolic intracellular free calcium ([Ca2+]i) was studied in single ventricular myocytes of 10-day-old embryonic chick heart, 20-week-old human fetus and rabbit aorta (VSM) single cells using the Ca2+-sensitive fluorescent dye, Fura-2 microfluorometry and digital imaging technique. Depolarization of the cell membrane of both heart and VSM cells with continuous superfusion of 30 mM [K+]o induced a rapid transient increase of [Ca2+]j that was followed by a sustained component. The early transient increase of [Ca2+]i by high [K+]o was blocked by the L-type calcium channel antagonist nifedipine. However, the sustained component was found to be insensitive to this drug. PN 200-110 another L-type Ca 2+ blocker was found to decrease both the early transient and the sustained increase of [Ca2+]i induced by depolarization of the cell membrane with high [K+]o. Insulin at a concentration of 40 to 80 tzU/rnl only produced a sustained increase of [Ca2+]i that was blocked by PN 200-110 or by lowering the extracellular Ca 2+ concentration with EGTA. The sustained increase of [Ca2+]i induced by high [K+]o or insulin was insensitive to metabolic inhibitors such as KCN and ouabain as well to the fast Na + channel blocker, tetrodotoxin and to the increase of intracellular concentrations of cyclic nucleotides. Using the patch clamp technique, insulin did not affect the L-type Ca 2+ current and the delayed outward K + current. These results suggest that the early increase of [Ca2+]i during depolarization of the cell membrane of heart and VSM cells with high [K+]o is due to the opening and decay of an L-type Ca z+ channel. However, the sustained increase of [Ca2+]i during a sustained depolarization is due to the activation of a resting (R) Ca 2+ channel that is insensitive to lowering [ATP]i and sensitive to insulin. (Mol Cell Biochem 117: 93--106, 1992)
Verifying cloud Service Level Agreement

In this paper we study the important issue of verifying Service Level Agreement (SLA) in a semi-trusted (or untrusted) cloud. Cloud computing services promise elastic computing and storage resources in a pay-as-you-go way. A SLA between a cloud service provider (CSP) and a user is a contract which specifies the resources and performances that the cloud should offer. However, the CSP has the incentive to cheat on SLA, e.g., providing users with less CPU and memory resources than that specified in the SLA, which allows the CSP to support more users and make more profits. A malicious CSP can disrupt the existing SLA monitoring/verification techniques by interfering the monitoring/measurement process. Therefore, we present a SLA verification framework that leverages a third party auditor (TPA). Under the TPA framework, we propose an effective testing algorithm that can detect SLA violations of physical memory size in virtual machine (VM). Using real experiments, we show that the algorithm can detect cloud cheating on VM memory size (i.e., SLA violations). Furthermore, our algorithm can defend various attacks from a malicious CSP, which tries to hide a SLA violation.
Micrometer-sized ice particles for planetary-science experiments – I. Preparation, critical rolling friction force, and specific surface energy

Coagulation models assume a higher sticking threshold for micrometer-sized ice particles than for micrometer-sized silicate particles. However, in contrast to silicates, laboratory investigations of the collision properties of micrometer-sized ice particles (in particular, of the most abundant water ice) have not been conducted yet. Thus, we used two different experimental methods to produce micrometer-sized water ice particles, i. e. by spraying water droplets into liquid nitrogen and by spraying water droplets into a cold nitrogen atmosphere. The mean particle radii of the ice particles produced with these experimental methods are (1.49 ± 0.79) μm and (1.45 ± 0.65) μm. Ice aggregates composed of the micrometer-sized ice particles are highly porous (volume filling factor: φ = 0.11 ± 0.01) or rather compact (volume filling factor: φ = 0.72 ± 0.04), depending on the method of production. Furthermore, the critical rolling friction force of FRoll,ice = (114.8 ± 23.8) × 10−10 N was measured for micrometer-sized ice particles, which exceeds the critical rolling friction force of micrometer-sized SiO2 particles (FRoll,S iO2 = (12.1±3.6)×10−10 N). This result implies that the adhesive bonding between micrometer-sized ice particles is stronger than the bonding strength between SiO2 particles. An estimation of the specific surface energy of micrometer-sized ice particles, derived from the measured critical rolling friction forces and the surface energy of micrometer-sized SiO2 particles, results in γice = 0.190 J m−2.
The structure and ore deposits of the Carboniferous Limestone of the Eyam district, Derbyshire

Summary The area described consists of Carboniferous Limestone almost surrounded by Edale Shales and an account of the stratigraphy is given. The uppermost group of limestones, belonging to the "reef", is shown to lie unconformably on the normal-bedded D 1 -D 2 limestones. Descriptions are given of the principal exposed sections through the limestones. Structure-contours based on the Orwnastraea placenta horizon high in the D 2 limestones demonstrate the tectonic movements of the mid-Carboniferous. The distribution of the main lead-ore veins is shown to be nearly related to the structures of the limestones.
Concomitant Socioeconomic, Behavioral, and Biological Factors Associated with the Disproportionate HIV Infection Burden among Black Men Who Have Sex with Men in 6 U.S. Cities

BACKGROUND
American Black men who have sex with men (MSM) are disproportionately affected by HIV, but the factors associated with this concentrated epidemic are not fully understood.


METHODS
Black MSM were enrolled in 6 US cities to evaluate a multi-component prevention intervention, with the current analysis focusing on the correlates of being newly diagnosed with HIV compared to being HIV-uninfected or previously diagnosed with HIV.


RESULTS
HPTN 061 enrolled 1553 Black MSM whose median age was 40; 30% self-identified exclusively as gay or homosexual, 29% exclusively as bisexual, and 3% as transgender. About 1/6(th) (16.2%) were previously diagnosed with HIV (PD); of 1263 participants without a prior HIV diagnosis 7.6% were newly diagnosed (ND). Compared to PD, ND Black MSM were younger (p<0.001); less likely to be living with a primary partner (p<0.001); more likely to be diagnosed with syphilis (p<0.001), rectal gonorrhea (p = 0.011) or chlamydia (p = 0.020). Compared to HIV-uninfected Black MSM, ND were more likely to report unprotected receptive anal intercourse (URAI) with a male partner in the last 6 months (p<0.001); and to be diagnosed with syphilis (p<0.001), rectal gonorrhea (p = 0.004), and urethral (p = 0.025) or rectal chlamydia (p<0.001). They were less likely to report female (p = 0.002) or transgender partners (p = 0.018). Multivariate logistic regression analyses found that ND Black MSM were significantly more likely than HIV-uninfected peers to be unemployed; have STIs, and engage in URAI. Almost half the men in each group were poor, had depressive symptoms, and expressed internalized homophobia.


CONCLUSIONS
ND HIV-infected Black MSM were more likely to be unemployed, have bacterial STIs and engage in URAI than other Black MSM. Culturally-tailored programs that address economic disenfranchisement, increase engagement in care, screen for STIs, in conjunction with safer sex prevention interventions, may help to decrease further transmission in this heavily affected community.
The Nobel Memorial Prize for Robert F. Engle

I review and interpret two of Robert Engle's most important contributions: the theory and application of cointegration, and the theory and application of dynamic volatility models. I treat the latter much more extensively, de-emphasizing technical aspects and focusing instead on the intuition, nuances and importance of the work.
Kawasaki disease.

PURPOSE OF REVIEW
Kawasaki disease is still a dilemma for pediatricians, especially its atypical or incomplete presentation. The current diagnostic criteria appear inadequate, and the early diagnosis frequently remains challenging with high risk of coronary damage. This review focuses on recent data concerning Kawasaki disease etiology and pathogenesis, and emphasizes the proposal of including altered laboratory values in revised diagnostic criteria aimed at identifying patients with incomplete disease.


RECENT FINDINGS
Despite a timely treatment, approximately 15% of children have persistent or recurrent fever, thus requiring additional intravenous immunoglobulin, corticosteroids, immunosuppressant, and eventually biologic drugs. Recent cardiologic tests strongly suggest that endothelial damage may lead to coronary stenosis and myocardial ischemia over time, even in children apparently normal at initial cardiac evaluation. New noninvasive tools are suggested to monitor coronary artery aneurysm outcome. Giant coronary artery aneurysms still represent a severe life-threatening complication. There is as yet no agreement regarding the prevention of thrombosis and stenosis in children with giant aneurysms.


SUMMARY
Due to earlier recognition, aggressive medical treatment, and surgical procedures, the quality of life in patients with Kawasaki disease is significantly improved. The identification of children at high risk for coronary artery aneurysms is crucial in order to reduce the occurrence of sudden death in adolescence and early adulthood. High parameters of inflammation, anemia, and low sodium and albumin levels, along with persistent unexplained fever, should alert clinicians to suspect the disease even though all clinical symptoms are lacking.
LEO Satellite Constellation for Internet of Things

Internet of Things (IoT) is one of the evolutionary directions of the Internet. This paper focuses on the low earth orbit (LEO) satellite constellation-based IoT services for their irreplaceable functions. In many cases, IoT devices are distributed in remote areas (e.g., desert, ocean, and forest) in some special applications, they are placed in some extreme topography, where are unable to have direct terrestrial network accesses and can only be covered by satellite. Comparing with the traditional geostationary earth orbit (GEO) systems, LEO satellite constellation has the advantages of low propagation delay, small propagation loss and global coverage. Furthermore, revision of existing IoT protocol are necessary to enhance the compatibility of the LEO satellite constellation-based IoT with terrestrial IoT systems. In this paper, we provide an overview of the architecture of the LEO satellite constellation-based IoT including the following topics: LEO satellite constellation structure, efficient spectrum allocation, heterogeneous networks compatibility, and access and routing protocols.
Staff attitudes toward patients with borderline personality disorder.

OBJECTIVE
Our aims were (1) to develop 2 inventories for the measurement of cognitive and emotional attitudes toward borderline personality disorder (BPD) patients and their treatment and (2) to use these tools to understand and compare attitudes of psychiatrists, psychologists, and nurses toward BPD patients.


METHOD
Two lists of items referring to cognitive (47 items) and emotional attitudes (20 items) toward BPD patients were formulated. Fifty-seven clinicians (25 nurses, 13 psychologists, and 19 psychiatrists), who had been working in public psychiatric institutions for more than 1 year, rated their level of agreement with each item. The list of cognitive attitudes yielded 3 factors (required treatment, suicidal tendencies, and antagonistic judgment). The list of emotional attitudes yielded 3 other factors (negative emotions, experienced difficulties in treatment, and empathy).


RESULTS
Psychologists scored lower than psychiatrists and nurses on antagonistic judgments, whereas nurses scored lower than psychiatrists and psychologists on empathy. Regression stepwise analyses conducted on the 3 emotional attitudes separately showed that suicidal tendencies of BPD patients mainly explained the negative emotions and the difficulties in treating these patients. All groups were interested in learning more about the treatment of these patients.


CONCLUSIONS
Suicidal tendencies of BPD patients provoke antagonistic judgments among the 3 professions. Nevertheless, psychiatrists, psychologists, and nurses hold distinctive cognitive and emotional attitudes toward these patients. Mapping these differences can improve the education and training in the management of BPD patients.