LLukas22/scidocs huggingface dataset:
Early skin-to-skin contact for mothers and their healthy newborn infants.

BACKGROUND
Mother-infant separation postbirth is common in Western culture. Early skin-to-skin contact (SSC) begins ideally at birth and involves placing the naked baby, covered across the back with a warm blanket, prone on the mother's bare chest. According to mammalian neuroscience, the intimate contact inherent in this place (habitat) evokes neurobehaviors ensuring fulfillment of basic biological needs. This time may represent a psychophysiologically 'sensitive period' for programming future behavior.


OBJECTIVES
To assess the effects of early SSC on breastfeeding, behavior, and physiological adaptation in healthy mother-newborn dyads.


SEARCH STRATEGY
Cochrane Pregnancy and Childbirth Group's and Neonatal Group's Trials Registers (August 2006), Cochrane Central Register of Controlled Trials (The Cochrane Library 2006, Issue 2), MEDLINE (1976 to 2006).


SELECTION CRITERIA
Randomized and quasi-randomized clinical trials comparing early SSC with usual hospital care.


DATA COLLECTION AND ANALYSIS
We independently assessed trial quality and extracted data. Study authors were contacted for additional information.


MAIN RESULTS
Thirty studies involving 1925 participants (mother-infant dyads), were included. Data from more than two trials were available for only 8-of-64 outcome measures. We found statistically significant and positive effects of early SSC on breastfeeding at one to four months postbirth (10 trials; 552 participants) (odds ratio (OR) 1.82, 95% confidence interval (CI) 1.08 to 3.07), and breastfeeding duration (seven trials; 324 participants) (weighted mean difference (WMD) 42.55, 95% CI -1.69 to 86.79). Trends were found for improved summary scores for maternal affectionate love/touch during observed breastfeeding (four trials; 314 participants) (standardized mean difference (SMD) 0.52, 95% CI 0.07 to 0.98) and maternal attachment behavior (six trials; 396 participants) (SMD 0.52, 95% CI 0.31 to 0.72) with early SSC. SSC infants cried for a shorter length of time (one trial; 44 participants) (WMD -8.01, 95% CI -8.98 to -7.04). Late preterm infants had better cardio-respiratory stability with early SSC (one trial; 35 participants) (WMD 2.88, 95% CI 0.53 to 5.23). No adverse effects were found.


AUTHORS' CONCLUSIONS
Limitations included methodological quality, variations in intervention implementation, and outcome variability. The intervention may benefit breastfeeding outcomes, early mother-infant attachment, infant crying and cardio-respiratory stability, and has no apparent short or long-term negative effects. Further investigation is recommended. To facilitate meta-analysis, future research should be done using outcome measures consistent with those in the studies included here. Published reports should clearly indicate if the intervention was SSC and include means, standard deviations, exact probability values, and data to measure intervention dose.
Vaccination strategies against Zika virus.

The epidemic emergence of Zika virus (ZIKV) in 2015-2016 has been associated with congenital malformations and neurological sequela. Current efforts to develop a ZIKV vaccine build on technologies that successfully reduced infection or disease burden against closely related flaviviruses or other RNA viruses. Subunit-based (DNA plasmid and modified mRNA), viral vectored (adeno- and measles viruses) and inactivated viral vaccines are already advancing to clinical trials in humans after successful mouse and non-human primate studies. Among the greatest challenges for the rapid implementation of immunogenic and protective ZIKV vaccines will be addressing the potential for exacerbating Dengue virus infection or causing Guillain-Barré syndrome through production of cross-reactive immunity targeting related viral or host proteins. Here, we review vaccine strategies under development for ZIKV and the issues surrounding their usage.
Investigation of Flow Behavior in Minimum Quantity Lubrication Nozzle for End Milling Processes

Minimum quantity lubrication (MQL) is a sustainable manufacturing technique that has replaced conventional flooded lubrication methods and dry machining. In the MQL technique, the lubricant is sprayed onto the friction surfaces through nozzles through small pneumatically-operated pumps. This paper presents an investigation into the flow behavior of the lubricant and air mixture under certain pressures at the tip of a nozzle specially designed for MQL. The nozzle used is an MQL stainless steel nozzle, 6.35 mm in diameter. Computational fluid dynamics is used to determine the flow pattern at the tip of the nozzle where the lubricant and compressed air are mixed to form a mist. The lubricant volume flow is approximately 0.08 ml/cycle of the pump. A transient, pressure-based, threedimensional analysis is performed with a viscous, realizable k-ε model. The results are obtained in the form of vector plots and flow fields. The flow mixing at the tip of the nozzle is wholly shown through the flow fields and vector plots. This study provides an insight into the flow distribution at the tip of the nozzle for a certain pressure to aid modifications in the design of the nozzle for future MQL studies. It attainable aids to determine the correct pressure for the air jet at the nozzle tip.
Numerical solutions for micropolar transport phenomena over a nonlinear stretching sheet

Department of Mathematics, Indian Institute of Technology, Roorkee, I ndia Department of Engineering, Manchester Metropolitan University Manchester, M1 5GD, England, UK 3 Fire Safety Engineering Science Program Leeds College of Building, Leeds Metropolitan University North Street, Leeds, LS2 7QT, England obeg@lcb.ac.uk; docoabeg@hotmail.com Department of Civil Engineering, Indian Institute of Technology, Roor kee, India
Wireless software-defined networks (W-SDNs) and network function virtualization (NFV) for 5G cellular systems: An overview and qualitative evaluation

Cellular network technologies have evolved to support the ever-increasing wireless data traffic, which results from the rapidly-evolving Internet and widely-adopted cloud applications over wireless networks. However, hardware-based designs, which rely on closed and inflexible architectures of current cellular systems, make a typical 10-year cycle for a new generation of wireless networks to be standardized and deployed. To overcome this limitation, the concept of software-defined networking (SDN) has been proposed to efficiently create centralized network abstraction with the provisioning of programmability over the entire network. Moreover, the complementary concept of network function virtualization (NFV) has been further proposed to effectively separate the abstraction of functionalities from the hardware by decoupling the data forwarding plane from the control plane. These two concepts provide cellular networks with the needed flexibility to evolve and adapt according to the ever-changing network context and introduce wireless software-defined networks (W-SDNs) for 5G cellular systems. Thus, there is an urgent need to study the fundamental architectural principles underlying a new generation of software-defined cellular network as well as the enabling technologies that supports and manages such emerging architecture. In this paper, first, the state-of-the-art W-SDNs solutions along with their associated NFV techniques are surveyed. Then, the key differences among these W-SDN solutions as well as their limitations are highlighted. To counter those limitations, SoftAir, a new SDN architecture for 5G cellular systems, is introduced. © 2015 Elsevier B.V. All rights reserved. Full Article
Session-based adaptive overload control for secure dynamic Web applications

As dynamic Web content and security capabilities are becoming popular in current Web sites, the performance demand on application servers that host the sites is increasing, leading sometimes these servers to overload. As a result, response times may grow to unacceptable levels and the server may saturate or even crash. In this paper we present a session-based adaptive overload control mechanism based on SSL (secure socket layer) connections differentiation and admission control. The SSL connections differentiation is a key factor because the cost of establishing a new SSL connection is much greater than establishing a resumed SSL connection (it reuses an existing SSL session on server). Considering this big difference, we have implemented an admission control algorithm that prioritizes the resumed SSL connections to maximize performance on session-based environments and limits dynamically the number of new SSL connections accepted depending on the available resources and the current number of connections in the system to avoid server overload. In order to allow the differentiation of resumed SSL connections from new SSL connections we propose a possible extension of the Java Secure Sockets Extension (JSSE) API. Our evaluation on Tomcat server demonstrates the benefit of our proposal for preventing server overload.
Is Blood Eosinophil Count a Predictor of Response to Bronchodilators in Chronic Obstructive Pulmonary Disease? Results from Post Hoc Subgroup Analyses

BACKGROUND
Chronic obstructive pulmonary disease (COPD) patients with blood eosinophil (EOS) count ≥ 2% benefit from exacerbation reductions with inhaled corticosteroids (ICSs). We conducted post hoc analyses to determine if EOS count ≥ 2% is a marker for greater responsiveness to the bronchodilators umeclidinium (UMEC; long-acting muscarinic antagonist), vilanterol (VI; long-acting β2-agonist) or UMEC/VI combination.


METHODS
Effects of once-daily UMEC/VI 62.5/25, UMEC 62.5 and VI 25 µg versus placebo on trough forced expiratory volume in one second (FEV1), Transition Dyspnoea Index (TDI), St George's Respiratory Questionnaire (SGRQ) scores and adverse event (AE) incidences in four completed, 6-month studies were assessed by EOS subgroup. Trough FEV1 was also evaluated by ICS use and EOS subgroup. Analyses were performed using a repeated measures model.


RESULTS
At baseline, 2437 of 4647 (52%) patients had EOS count ≥ 2%. Overall, ≈ 50% of patients used ICSs. At day 169, no notable variations were observed in trough FEV1 least squares mean differences between EOS subgroups versus placebo for UMEC/VI, UMEC and VI; results according to ICS use were similar. No differences were reported between EOS subgroups in TDI and SGRQ scores on day 168, or for incidences of AEs, serious AEs and AEs leading to withdrawal.


CONCLUSIONS
Response to UMEC/VI, UMEC and VI in terms of trough FEV1, dyspnoea and health-related quality of life was similar for COPD patients with baseline EOS counts ≥ 2 or <2%. EOS count did not appear to predict bronchodilator response in either ICS users or non-users.
Pre-hospital electrocardiogram triage with tele-cardiology support is associated with shorter time-to-balloon and higher rates of timely reperfusion even in rural areas: data from the Bari- Barletta/Andria/Trani public emergency medical service 118 registry on primary angioplasty in ST-elevation myo

BACKGROUND
We report the preliminary data from a regional registry on ST-elevation myocardial infarction (STEMI) patients treated with primary angioplasty in Apulia, Italy; the region is covered by a single public health-care service, a single public emergency medical service (EMS), and a single tele-medicine service provider.


METHODS
Two hundred and ninety-seven consecutive patients with STEMI transferred by regional free public EMS 1-1-8 for primary-PCI were enrolled in the study; 123 underwent pre-hospital electrocardiograms (ECGs) triage by tele-cardiology support and directly referred for primary-PCI, those remaining were just transferred by 1-1-8 ambulances for primary percutaneous coronary intervention (PCI) (diagnosis not based on tele-medicine ECG; already hospitalised patients, emergency-room without tele-medicine support). Time from first ECG diagnostic for STEMI to balloon was recorded; a time-to-balloon <1 h was considered as optimal and patients as timely treated.


RESULTS
Mean time-to-balloon with pre-hospital triage and tele-cardiology ECG was significantly shorter (0:41 ± 0:17 vs 1:34 ± 1:11 h, p<0.001, -0:53 h, -56%) and rates of patients timely treated higher (85% vs 35%, p<0.001, +141%), both in patients from the 'inner' zone closer to PCI catheterisation laboratories (0:34 ± 0:13 vs 0:54 ± 0:30 h, p<0.001; 96% vs 77%, p<0.01, +30%) and in the 'outer' zone (0:52 ± 0:17 vs 1:41 ± 1:14 h, p<0.001; 69% vs 29%, p<0.001, +138%). Results remained significant even after multivariable analysis (odds ratio for time-to-balloon 0.71, 95% confidence interval (CI) 0.63-0.80, p<0.001; 1.39, 95% CI 1.25-1.55, p<0.001, for timely primary-PCI).


CONCLUSIONS
Pre-hospital triage with tele-cardiology ECG in an EMS registry from an area with more than one and a half million inhabitants was associated with shorter time-to-balloon and higher rates of timely treated patients, even in 'rural' areas.
Acquisition of the constraints on wanna contraction by advanced second language learners : Universal Grammar and imperfect knowledge

Contraction of want to to wanna is subject to constraints which have been related to the operation of Universal Grammar. Contraction appears to be blocked when the trace of an extracted wh-word intervenes. Evidence for knowledge of these constraints by young English-speaking children in as been taken to show the operation of Universal Grammar in early child language acquisition. The present study investigates the knowledge these constraints in adults, both English native speakers and advanced Korean learners of English. The results of three experiments, using elicited production, oral repair, and grammaticality judgements, confirmed native speaker knowledge of the constraints. A second process of phonological elision may also operate to produce wanna. Learners also showed some differentiation of contexts, but much less clearly than native speakers. We speculate that non-natives may be using rules of complement selection, rather than the constraints of UG, to control contraction. Introduction: wanna contraction and language learnability In English, want to can be contracted to wanna, but not invariably. As first observed by Lakoff (1970) in examples such as (1), in which the object of the infinitival complement of want has been extracted by wh-movement, contraction is possible, but not in (2), in which the subject of the infinitival complement is extracted from the position between want and to. We shall call examples like (1) "subject extraction questions" (SEQ) and examples like (2) "object extraction questions" (OEQ).
Dose and polymorphic genes xrcc1, xrcc3, gst play a role in the risk of articledeveloping erythema in breast cancer patients following single shot partial breast irradiation after conservative surgery

To evaluate the association between polymorphisms involved in DNA repair and oxidative stress genes and mean dose to whole breast on acute skin reactions (erythema) in breast cancer (BC) patients following single shot partial breast irradiation (SSPBI) after breast conservative surgery. Acute toxicity was assessed using vers.3 criteria. single nucleotides polymorphisms(SNPs) in genes: XRCC1(Arg399Gln/Arg194Trp), XRCC3 (A4541G-5'UTR/Thr241Met), GSTP1(Ile105Val), GSTA1 and RAD51(untranslated region). SNPs were determined in 57 BC patients by the Pyrosequencing analysis. Univariate(ORs and 95% CI) and logistic multivariate analyses (MVA) were performed to correlate polymorphic genes with the risk of developing acute skin reactions to radiotherapy. After SSPBI on the tumour bed following conservative surgery, grade 1 or 2 acute erythema was observed in 19 pts(33%). Univariate analysis indicated a higher significant risk of developing erythema in patients with polymorphic variant wt XRCC1Arg194Trp, mut/het XRCC3Thr241Met, wt/het XRCC3A4541G-5'UTR. Similarly a higher erythema rate was also found in the presence of mut/het of XRCC1Arg194Trp or wt of GSTA1. Whereas, a lower erythema rate was observed in patients with mut/het of XRCC1Arg194Trp or wt of XRCC1Arg399Gln. The mean dose to whole breast(p = 0.002), the presence of either mut/het XRCC1Arg194Trp or wt XRCC3Thr241Met (p = 0.006) and the presence of either mut/het XRCC1Arg194Trp or wt GSTA1(p = 0.031) were confirmed as predictors of radiotherapy-induced erythema by MVA. The Whole breast mean dose together with the presence of some polymorphic genes involved in DNA repair or oxidative stress could explain the erythema observed after SSPBI, but further studies are needed to confirm these results in a larger cohort. ClinicalTrials.gov Identifier: NCT01316328
Linking Business Intelligence into Your Business

IT departments are under pressure to serve their enterprises by professionalizing their business intelligence (BI) operation. Companies can only be effective when their systematic and structured approach to BI is linked into the business itself.
Purification and properties of an enantioselective and thermoactive amidase from the thermophilic actinomycete Pseudonocardia thermophila

A constitutively expressed thermoactive amidase from the thermophilic actinomycete Pseudonocardia thermophila was purified to homogeneity by applying hydrophobic interaction, anion exchange and gel filtration chromatography, giving a yield of 26% and a specific activity of 19.5 units mg−1. The purified enzyme has an estimated molecular mass of 108 kDa and an isoelectric point of 4.2. The amidase is active at a broad pH range (pH 4–9) and temperature range (40–80°C) and has a half-life of 1.2 h at 70°C. Inhibition of enzyme activity was observed in the presence of metal ions, such as Co2+, Hg2+, Cu2+, Ni2+, and thiol reagents. The amidase has a broad substrate spectrum, including aliphatic, aromatic and amino acid amides. The presence of a double bond or a methyl group near the carboxamide group of aliphatic and amino acid amides enhances the enzymatic activity. Among aromatic amides with substitutions at the o-, m-, or p-position, the p-substituted amides are the preferred substrates. The highest acyl transferase activity was detected with hexanoamide, isobutyramide and propionamide. The K m values for propionamide, methacrylamide, benzamide and 2-phenylpropionamide are 7.4, 9.2, 4.9 and 0.9 mM, respectively. The amidase is highly S-stereoselective for 2-phenylpropionamide; and the racemic amide was converted to the corresponding S-acid with an enantiomeric excess of >95% at 50% conversion of the substrate. In contrast, the d,l-tryptophanamide and d,l-methioninamide were converted to the corresponding d,l-acids at the same rate. This thermostable enzyme represents the first reported amidase from a thermophilic actinomycete.
Endotoxin contamination in the dental surgery.

Dental waterlines contain large numbers of Gram-negative bacteria. Endotoxin, a component of such organisms, has significant health implications. Paired samples of dental unit water and the aerosols generated during dental procedures were collected, and assayed for bacteria and endotoxin levels, using heterotrophic plate counts and the Limulus amoebocyte lysate test. Consistent with published studies, the extent of bacterial contamination in the dental waters sampled for this investigation surpassed the levels associated with potable water, with counts in excess of 2.0x10(6) c.f.u. ml(-1) in some samples. Correspondingly high concentrations of endotoxin [up to 15 000 endotoxin units (EU) ml(-1)] were present in the water. A statistically significant Spearman correlation coefficient of rho=0.94 between endotoxin (EU ml(-1)) and bacterial load (c.f.u. ml(-1)) was demonstrated. All of the aerosol samples contained detectable endotoxin. Further studies of the consequences of dental endotoxin exposure, and evaluation of means to prevent exposure, are warranted.
Treatment of lymphangiomas with OK-432 (Picibanil) sclerotherapy: a prospective multi-institutional trial.

OBJECTIVE
To describe and to determine the robustness of our study evaluating the efficacy of OK-432 (Picibanil) as a therapeutic modality for lymphangiomas.


DESIGN AND SETTING
Prospective, randomized trial and parallel-case series at 13 US tertiary care referral centers.


SUBJECTS
Thirty patients diagnosed as having lymphangioma. Ages in 25 ranged from 6 months to 18 years. Twenty-nine had lesions located in the head-and-neck area.


INTERVENTION
Every patient received a 4-dose injection series of OK-432 scheduled 6 to 8 weeks apart unless a contraindication existed or a complete response was observed before completion of all injections. A control group was observed for 6 months.


OUTCOME MEASURES
Successful outcome of therapy was defined as a complete or a substantial (>60%) reduction in lymphangioma size as determined by calculated lesion volumes on computed tomographic or magnetic resonance imaging scans.


RESULTS
Overall, 19 (86%) of the 22 patients with predominantly macrocystic lymphangiomas had a successful outcome.


CONCLUSIONS
OK-432 should be efficacious in the treatment of lymphangiomas. Our study design is well structured to clearly define the role of this treatment agent.
CUSTOMER LIFETIME VALUE: MARKETING MODELS AND APPLICATIONS

the topic (a) has been dedicated to extolling its use as a decisionmaking criterion; (b) has presented isolated numerical examples of its calculation/determination; and (c) has considered it as part of the general discussions of profitability and discussed its role in customer acquisition decisions and customer acquisition/retention trade-offs. There has been a dearth of general modeling of the topic. This paper presents a series of mathematical models for determination of customer lifetime value. The choice of the models is based on a systematic theoretical taxonomy and on assumptions grounded in customer behavior. In NADA I. NASR is a doctoral student in Marketing at the School addition, selected managerial applications of these general models of of Management, Boston University. customer lifetime value are offered. 1998 John Wiley & Sons, Inc. and Direct Marketing Educational Foundation, Inc. CCC 1094-9968/98/010017-14
Incidence of metabolic syndrome among night-shift healthcare workers.

OBJECTIVE
Night-shift work is associated with ischaemic cardiovascular disorders. It is not currently known whether it may be causally linked to metabolic syndrome (MS), a risk condition for ischaemic cardiovascular disorders. The syndrome presents with visceral obesity associated with mild alterations in glucidic and lipidic homeostasis, and in blood pressure. The aim of this study was to assess whether a causal relationship exists between night-shift work and the development of MS.


METHODS
Male and female nurses performing night shifts, free from any component of MS at baseline, were evaluated annually for the development of the disorder during a 4-year follow-up. Male and female nurses performing daytime work only, visited during the same time period, represented the control group.


RESULTS
The cumulative incidence of MS was 9.0% (36/402) among night-shift workers, and 1.8% (6/336) among daytime workers (relative risk (RR) 5.0, 95% CI -2.1 to 14.6). The annual rate of incidence of MS was 2.9% in night-shift workers and 0.5% in daytime workers. Kaplan-Meier survival curves of the two groups were significantly different (log-rank test; p<0.001). Multiple Cox regression analysis (forward selection method based on likelihood ratio) showed that among selected variables (age, gender, smoking, alcohol intake, familiar history, physical activity, and work schedule) the only predictors of occurrence of MS were sedentariness (hazard ratio (HR) 2.92; 95% CI 1.64 to 5.18; p = 0.017), and night-shift work (HR 5.10; 95% CI 2.15 to 12.11; p<0.001).


CONCLUSIONS
The risk of developing MS is strongly associated with night-shift work in nurses. Medical counselling should be promptly instituted in night-shift workers with the syndrome, and in case of persistence or progression, a change in work schedule should be considered.