LLukas22/scidocs huggingface dataset:
Eosinophilic colitis: epidemiology, clinical features, and current management.

Primary eosinophilic gastrointestinal disorders (EGIDs) represent a spectrum of inflammatory gastrointestinal disorders in which eosinophils infiltrate the gut in the absence of known causes for such tissue eosinophilia. EGIDs can be subgrouped as eosinophilic esophagitis (EE), eosinophilic gastroenteritis (EG), and eosinophilic colitis (EC). The least frequent manifestation of EGIDs is EC. EC is a heterogeneous entity with a bimodal age distribution, presenting with either an acute self-limited bloody diarrhea in otherwise healthy infants or as a more chronic relapsing colitis in young adults. The pathophysiology of primary EC appears related to altered hypersensitivity, principally as a food allergy in infants and T lymphocyte-mediated (i.e. non-IgE associated) in young adults. In adults, symptoms include diarrhea, abdominal pain, and weight loss. Endoscopic changes are generally modest, featuring edema and patchy granularity. Although standardized criteria are not yet established, the diagnosis of EC depends on histopathology that identifies an excess of eosinophils. Therapeutic approaches are based on case reports and small case series, as prospective randomized controlled trials are lacking. Eosinophilic colitis in infants is a rather benign, frequently food-related entity and dietary elimination of the aggressor often resolves the disorder within days. Adolescent or older patients require more aggressive medical management including: glucocorticoids, anti-histamines, leukotriene receptors antagonists as well as novel approaches employing biologics that target interleukin-5 (IL-5) and IgE. This review article summarizes the current knowledge of EC, its epidemiology, clinical manifestations, diagnosis, and treatment.
An enhancement to SePeCloud with improved security and efficient data management

Outsourcing data to a third-party controlled cloud computing services arises various security issues. High security schemes are required to protect data in the cloud platform. Division and Replication of Data in the Cloud for Optimal Performance and Security (DROPS) method addressed these issues by improving the security and performance of a cloud environment. An enhanced version of DROPS named SePeCloud was proposed that improved the security and performance hand-in-hand with Fog based Deduplication and Privacy Preserving Online Updating. This paper improves the security and data storage with Self-Destruction mechanism by handling the applications independently built on reinforcement learning strategy. Data chunk fingerprint index and sketch index are included to support independent and parallel data destruction among multiple applications. Additionally, SePeCloud is further extended to prevent impersonation attacks from illegitimate users by introducing Modified Shamir secrete sharing scheme to handle user revocation policies with limited storage space. The experimental results prove that the final version of the SePeCloud performed better than the previous versions in terms of Replication cost savings and Computation time by improving both security and performance of the cloud system.
The selective serotonin reuptake inhibitor paroxetine is effective in more generalized and in less generalized social anxiety disorder

Rationale: The DSM-IV includes the specifier "generalized" to refer to social anxiety disorder (social phobia) patients if the fears include "most social situations". The focus on interventions such as the selective serotonin reuptake inhibitors (SSRIs) for generalized social anxiety disorder arguably runs the risk that inadequate treatment will be provided to patients with the non-generalized or discrete subtypes. There are, however, few data to address whether more generalized and less generalized subgroups of social anxiety disorder differ in response to medication. Objective: To compare response of more generalized and less generalized social anxiety disorder to pharmacotherapy. Methods: Data from three randomized placebo-controlled double-blind multicenter trials of the SSRI paroxetine in social anxiety disorder were pooled. Response on the Clinical Global Impression Global Improvement item was analyzed using logistic regression, and change in total Liebowitz Social Anxiety Score was analyzed using analysis of variance, with both models incorporating treatment (paroxetine vs placebo), subgroup (more generalized vs less generalized), demographic, and clinical variables. Results: The prevalence of more generalized social anxiety disorder was higher in females than in males. However, there was no significant difference in terms of age or clinical characteristics (duration of condition, baseline pulse, mean arterial blood pressure). At treatment endpoint there were significant treatment effects (for paroxetine vs placebo), but no significant subgroup effects (for more generalized vs less generalized). Conclusions: Although the current database is limited insofar as few patients with discrete social anxiety disorder would have been included, it is helpful in addressing the value of medication for patients lying on the spectrum from generalized to non-generalized and discrete social anxiety disorder. Paroxetine was effective in both more generalized and in less generalized social anxiety disorder.
A randomised trial of a 5 week, manual based, self-management programme for hypertension delivered in a cardiac patient club in Shanghai

BACKGROUND
In Shanghai there are 1.2 million people with hypertension, many of whom have difficulty in affording medical treatment. Community based, anti-hypertensive clubs have been created to provide health education but education alone is often ineffective. Lifestyle change programmes have shown some potential for reducing blood pressure but in previous trials have required specialist staff and extensive contact. We have previously demonstrated that self-management programmes delivered by health professionals, such as a nurse who has had short training in self-management techniques can change health behaviour and reduce symptoms. This study was designed to evaluate the benefits of a simple, cognitive-behavioural, self-management programme for hypertension based around a hypertension manual and delivered in the setting of a community anti-hypertensive club in Shanghai.


METHOD
The method was a pragmatic randomised controlled trial with an intention-to-treat analysis. Adult patients with mild-to-moderate primary hypertension, waiting to join a neighbourhood anti-hypertension club, were randomised to the self-management programme or to an information only control procedure. They attended the group treatment sessions on 4 occasions over 5 weeks for education combined with goal setting for lifestyle change and an introduction to exercise. The main outcome measures were: changes in blood pressure; blood total cholesterol; diet; activity level and health related quality of life 1 month and 4 months after the end of treatment.


RESULTS
A total of 140 adults with mild-to-moderate primary hypertension took part. All of the main outcomes showed beneficial changes. Four months after the end of treatment the mean blood pressure differences between groups were systolic 10.15 mm Hg (P < 0.001, 95% CI 7.25-13.05), and diastolic 8.29 mmHg (P < 0.001, 95% CI 6.71-9.88). Patients in the intervention group also had significantly reduced weight, lowered blood total cholesterol, increased physical activity and improved quality of life.


CONCLUSION
Patients with mild-to-moderate primary hypertension attending a 5 week, group and manual based, cognitive-behavioural self-management programme, delivered through a voluntary club in Shanghai experienced a significant reduction in blood pressure.


TRIAL REGISTRATION
Current Controlled Trials ISRCTN73114566.
Twelve tips for giving feedback effectively in the clinical environment.

BACKGROUND
Feedback is an essential element of the educational process for clinical trainees. Performance-based feedback enables good habits to be reinforced and faulty ones to be corrected. Despite its importance, most trainees feel that they do not receive adequate feedback and if they do, the process is not effective.


AIMS AND METHODS
The authors reviewed the literature on feedback and present the following 12 tips for clinical teachers to provide effective feedback to undergraduate and graduate medical trainees. In most of the tips, the focus is the individual teacher in clinical settings, although some of the suggestions are best adopted at the institutional level.


RESULTS
Clinical educators will find the tips practical and easy to implement in their day-to-day interactions with learners. The techniques can be applied in settings whether the time for feedback is 5 minutes or 30 minutes.


CONCLUSIONS
Clinical teachers can improve their skills for giving feedback to learners by using the straightforward and practical tools described in the subsequent sections. Institutions should emphasise the importance of feedback to their clinical educators, provide staff development and implement a mechanism by which the quantity and quality of feedback is monitored.
Factored Translation Models

We present an extension of phrase-based statistical machine translation models that enables the straight-forward integration of additional annotation at the word-level — may it be linguistic markup or automatically generated word classes. In a number of experiments we show that factored translation models lead to better translation performance, both in terms of automatic scores, as well as more grammatical coherence.
Admittance spectroscopy of Cu 2 ZnSnS 4 based thin film solar cells

Related Articles Structural properties and quasiparticle band structures of Cu-based quaternary semiconductors for photovoltaic applications J. Appl. Phys. 111, 063709 (2012) Electron drift-mobility measurements in polycrystalline CuIn1−xGaxSe2 solar cells Appl. Phys. Lett. 100, 103901 (2012) Modeling metastabilities in chalcopyrite-based thin film solar cells J. Appl. Phys. 111, 043703 (2012) Crystal and electronic structures of CuxS solar cell absorbers Appl. Phys. Lett. 100, 061906 (2012) Electrical modeling of Cu(In,Ga)Se2 cells with ALD-Zn1−xMgxO buffer layers J. Appl. Phys. 111, 014509 (2012)
Dynamic Airline Pricing and Seat Availability

Airfares are determined by both intertemporal price discrimination and dynamic adjustment to stochastic demand given limited capacity. In this paper I estimate a model of dynamic airline pricing taking both forces into account. I use an original data set of daily fares and seat availabilities at the flight level. With model estimates, I disentangle key interactions between the arrival pattern of consumer types and remaining capacity under stochastic demand. I find dynamic adjustment to stochastic demand is particularly important as a means to secure seats for high-valuing consumers who arrive close to the departure date. It leads to substantial revenue gains compared to pricing policies which depend on date of purchase but not remaining capacity. In aggregate consumers benefit, despite facing higher fares on average, as a result of more efficient capacity allocation. Finally, I show that failing to account for stochastic demand leads to a systematic bias in estimating demand elasticities. JEL Classifications: L11, L12, L93
Ferroelectric Ceramics : History and Technology Gene

Ferroelectric ceramics were born in the early 1940s with the discovery of the phenomenon of ferroelectricity as the source of the unusually high dielectric constant in ceramic barium titanate capacitors. Since that time, they have been the heart and soul of several multibillion dollar industries, ranging from high-dielectric-constant capacitors to later developments in piezoelectric transducers, positive temperature coefficient devices, and electrooptic light valves. Materials based on two compositional systems, barium titanate and lead zirconate titanate, have dominated the field throughout their history. The more recent developments in the field of ferroelectric ceramics, such as medical ultrasonic composites, high-displacement piezoelectric actuators (Moonies, RAINBOWS), photostrictors, and thin and thick films for piezoelectric and integrated-circuit applications have served to keep the industry young amidst its growing maturity. Various ceramic formulations, their form (bulk, films), fabrication, function (properties), and future are described in relation to their ferroelectric nature and specific areas of application.
Design of Absorptive/Transmissive Frequency-Selective Surface Based on Parallel Resonance

This communication presents a novel frequency-selective surface (FSS) with high in-band transmission at high frequency and wideband absorption at low frequency. It consists of a resistive sheet and a metallic bandpass FSS separated by a foam spacer. The resistive element is realized by inserting a strip-type parallel  $LC$  (PLC) structure into the center of a lumped-resistor-loaded metallic dipole. The PLC resonates at the passband of the bandpass FSS and exhibits an infinite impedance, which splits the resistive dipole into two short sections per the surface current; this setup allows for high in-band transmission at high frequency. Below the resonance frequency, the PLC becomes finite inductive and the entire FSS performs as an absorber with the metallic FSS as a ground plane. The surface current distribution on the resistive element can be controlled at various frequencies via the PLC structure. The wideband absorption and high in-band transmission of the proposed design are verified by both numerical simulation and experimental measurements. The potential extension to polarization-insensitive designs is also discussed.
Enhanced ethanol formation by Clostridium thermocellum via pyruvate decarboxylase

BACKGROUND
Pyruvate decarboxylase (PDC) is a well-known pathway for ethanol production, but has not been demonstrated for high titer ethanol production at temperatures above 50 °C.


RESULT
Here we examined the thermostability of eight PDCs. The purified bacterial enzymes retained 20% of activity after incubation for 30 min at 55 °C. Expression of these PDC genes, except the one from Zymomonas mobilis, improved ethanol production by Clostridium thermocellum. Ethanol production was further improved by expression of the heterologous alcohol dehydrogenase gene adhA from Thermoanaerobacterium saccharolyticum.


CONCLUSION
The best PDC enzyme was from Acetobactor pasteurianus. A strain of C. thermocellum expressing the pdc gene from A. pasteurianus and the adhA gene from T. saccharolyticum was able to produce 21.3 g/L ethanol from 60 g/L cellulose, which is 70% of the theoretical maximum yield.
A soft wearable robot for tremor assessment and suppression

Tremor constitutes the most common motor disorder, and poses a functional problem to a large number of patients. Despite of the considerable experience in tremor management, current treatment based on drugs or surgery does not attain an effective attenuation in 25 % of patients, motivating the need for research in new therapeutic alternatives. In this context, this paper presents the concept design, development, and preliminary validation of a soft wearable robot for tremor assessment and suppression. The TREMOR neurorobot comprises a Brain Neural Computer Interface that monitors the whole neuromusculoskeletal system, aiming at characterizing both voluntary movement and tremor, and a Functional Electrical Stimulation system that compensates for tremulous movements without impeding the user perform functional tasks. First results demonstrate the performance of the TREMOR neurorobot as a novel means of assessing and attenuating pathological tremors.
Magnetic-field perception

What is the evidence that animals perceive magnetic fields? The evidence for magnetoreception is mainly behavioural. The most common approach has been to alter the magnetic field around animals and watch for corresponding changes in orientation or navigation behaviour. Usually this has been done in the lab, where carefully calibrated magnetic fields can be produced. But experiments have also been done in the field on unrestrained animals that are migrating or homing. For example, standard bar magnets produce much stronger magnetic fields than Earth’s naturally occurring field, and placing these on homing pigeons and sea turtles disrupts navigation under some conditions. Neurobiological techniques have also provided evidence; in several cases, electrophysiological recordings and activity-dependent gene expression have revealed neurons, nerves and brain areas that show altered electrical activity in response to changes in the ambient field.
Transformational leadership , job satisfaction , and team performance : A multilevel mediation model of trust ☆

Article history: Received 2 December 2011 Received in revised 31 October 2012 Accepted 12 November 2012 Available online 11 December 2012 In spite of calls for deliberate differentiation between individual and team levels of analysis, leadership research based on well-grounded theory referring to multiple levels is scarce. We seek to fill this gap by analyzing the relations between transformational leadership, trust in supervisor and team, job satisfaction, and team performance via multilevel analysis. Results are based on a sample of 360 employees from 39 academic teams. Transformational leadership was positively related to followers' job satisfaction at individual as well as team levels of analysis and to objective team performance. The relation between individual perceptions of supervisors' transformational leadership and job satisfaction was mediated by trust in the supervisor as well as trust in the team. Yet, trust in the team did not mediate the relationship between team perceptions of supervisors' transformational leadership and team performance. Implications for theory and research of leadership at multiple levels as well as for practice are discussed. © 2012 Elsevier Inc. All rights reserved.
Relevance of gender in patients with acute myocardial infarction undergoing coronary interventions.

AIMS
To evaluate whether gender differences in terms of up to 4-year outcome still persist within patients with acute myocardial infarction (AMI) who uniformly underwent coronary revascularization, we performed a gender comparison in a large contemporary multicentre percutaneous intervention (PCI) registry.


MATERIALS AND METHODS
We retrospectively analyzed data from 18,351 patients with AMI, who underwent percutaneous coronary interventions (5093 women and 13,258 men) in the Emilia Romagna region of Italy between July 2002 and December 2007. Median follow-up was 1174 days.


RESULTS
After propensity score adjustment, differences in gender-related mortality were not temporarily homogeneous: 30-day adjusted mortality was higher in women than in men [hazard ratio (HR): 1.40, P < 0.0001], whereas thereafter female gender showed a significantly lower mortality risk (HR: 0.84, P = 0.01). Notably, younger women (<50 years old) both in the acute and postacute period had more than 3.6 higher risk of mortality when compared with men, whereas older women, particularly after the first 30-day post AMI, had similar (50-80 years old) or even better (≥ 80 years old) survival compared with men. Finally 1-month adjusted risk of heart failure and post PCI vascular complications requiring surgical treatment was higher in women while there was no detectable difference in terms of early and late AMI/unstable angina, stroke and angiographic stent thrombosis.


CONCLUSION
In a contemporary large real-world AMI population treated with PCI, we found gender-related temporal and age-dependent adjusted differences in mortality. Our data suggest the hypothesis that biological gender-related differences could, in part, explain these findings.
Need of Biomedical Waste Management System in Hospitals - An Emerging issue - A Review

Medical care is vital for our life and health, but the waste generated from medical activities represents a real problem of living nature and human world. Improper management of waste generated in health care facilities causes a direct health impact on the community, the health care workers and on the environment Every day, relatively large amount of potentially infectious and hazardous waste are generated in the health care hospitals and facilities around the world. Indiscriminate disposal of BMW or hospital waste and exposure to such waste possess serious threat to environment and to human health that requires specific treatment and management prior to its final disposal. The present review article deals with the basic issues as definition, categories, problems relating to biomedical waste and procedure of handling and disposal method of Biomedical Waste Management. It also intends to create awareness amongst the personnel involved in health care unit.
Cod liver oil and tuberculosis.

The Royal Brompton Hospital is well known for studies evaluating the use of streptomycin and other chemotherapy for tuberculosis (TB) in the 1940s to 1960s, but it is less widely known that the physicians at the hospital were already investigating treatments for TB 100 years earlier. This is a report of a study conducted in 1848. • Objective: to investigate the use of cod liver oil in the treatment of consumption (also known as phthisis, and now called tuberculosis or TB) in 19th century London
Atypical presentations and specific genotypes are associated with a delay in diagnosis in females with Rett syndrome.

There is often delay between onset of Rett syndrome symptoms and its diagnosis, possibly related to symptom presentation or socio-demographic factors. We hypothesized that girls with an atypical presentation or whose family had a lower socio-economic status would receive a later diagnosis. Female subjects with a confirmed diagnosis of Rett syndrome were sourced from the Australian Rett Syndrome and InterRett Databases. Variables analyzed included timing and development of symptoms; MECP2 mutation type; parental occupation and education; maternal age and birth order. Residential location and socio-economic status were also analyzed for the Australian cases. Linear regression was used to determine relationships between these factors and age at diagnosis. A total of 909 cases were included. An older age of diagnosis was associated with later loss of hand function and speech, later onset of hand stereotypies and the presence of the p.R133C or p.R294X MECP2 mutation. Socio-economic factors did not predict age of diagnosis for Australian families. For families participating in the InterRett database, a younger age of diagnosis was associated with higher levels of parental education or occupation. A clinical picture consistent with the classic presentation of Rett syndrome is associated with an earlier diagnosis. Clinicians need to be alerted to the variable presentation of Rett syndrome including the milder phenotypes of cases with the p.R133C or p.R294X mutation. Educational resources to assist this understanding including guidance on when to request genetic testing could be useful to streamline the process of diagnosis in Rett syndrome.