LLukas22/scidocs huggingface dataset:
18F-FDG PET/CT to Predict Response to Neoadjuvant Chemotherapy and Prognosis in Inflammatory Breast Cancer.

UNLABELLED
The aim of this prospective study was to assess the predictive value of (18)F-FDG PET/CT imaging for pathologic response to neoadjuvant chemotherapy (NACT) and outcome in inflammatory breast cancer (IBC) patients.


METHODS
Twenty-three consecutive patients (51 y ± 12.7) with newly diagnosed IBC, assessed by PET/CT at baseline (PET1), after the third course of NACT (PET2), and before surgery (PET3), were included. The patients were divided into 2 groups according to pathologic response as assessed by the Sataloff classification: pathologic complete response for complete responders (stage TA and NA or NB) and non-pathologic complete response for noncomplete responders (not stage A for tumor or not stage NA or NB for lymph nodes). In addition to maximum standardized uptake value (SUVmax) measurements, a global breast metabolic tumor volume (MTV) was delineated using a semiautomatic segmentation method. Changes in SUVmax and MTV between PET1 and PET2 (ΔSUV1-2; ΔMTV1-2) and PET1 and PET3 (ΔSUV1-3; ΔMTV1-3) were measured.


RESULTS
Mean SUVmax on PET1, PET2, and PET3 did not statistically differ between the 2 pathologic response groups. On receiver-operating-characteristic analysis, a 72% cutoff for ΔSUV1-3 provided the best performance to predict residual disease, with sensitivity, specificity, and accuracy of 61%, 80%, and 65%, respectively. On univariate analysis, the 72% cutoff for ΔSUV1-3 was the best predictor of distant metastasis-free survival (P = 0.05). On multivariate analysis, the 72% cutoff for ΔSUV1-3 was an independent predictor of distant metastasis-free survival (P = 0.01).


CONCLUSION
Our results emphasize the good predictive value of change in SUVmax between baseline and before surgery to assess pathologic response and survival in IBC patients undergoing NACT.
Traffic Sensitive Active Queue Management

Delay sensitive applications, such as voice over IP and network games, often sacrifice throughput for lower delay to obtain better quality. Unfortunately, the Internet does not allow an application to choose the amount of delay or throughput it receives and instead packets from all applications receive the same best-effort service. This paper presents a new QoS mechanism called the traffic sensitive quality of service controller (TSQ) that provides better delay performance for delay sensitive applications and higher throughput for throughput sensitive applications. Also contributed are quality metrics for some typical Internet applications that can be used by an application to adapt its delay hints and evaluate QoS based on current Internet traffic conditions. Experiments suggest TSQ's benefits to performance along with retention of the current best-effort Internet environment without complicated traffic monitoring or policing.
Role of humanitarian culture of the innovator personality at split of responsibility and equity in innovation project company

Content of humanitarian culture of the personality in relation to representatives of engineering professions is revealed, its influence on results of split of responsibility and equity in innovative project company is shown.
Pilot study of losartan for pulmonary hypertension in chronic obstructive pulmonary disease

BACKGROUND
Morbidity in COPD results from a combination of factors including hypoxia-induced pulmonary hypertension, in part due to pulmonary vascular remodelling. Animal studies suggest a role of angiotensin II and acute studies in man concur. Whether chronic angiotensin-II blockade is beneficial is unknown. We studied the effects of an angiotensin-II antagonist losartan, on haemodynamic variables, exercise capacity and symptoms.


METHODS
This was a double-blind, randomized, parallel group, placebo- controlled study of 48 weeks duration. Forty patients with COPD and pulmonary hypertension (Tran tricuspid pressure gradient (TTPG) = 30 mmHg) were randomised to losartan 50 mg or placebo. Changes in TTPG were assessed at 3, 6 and 12 months.


RESULTS
There was a trend for TTPG to increase in the placebo group (baseline 43.4 versus 48.4 mmHg at endpoint) and stay constant in the losartan group (baseline 42.8 versus 43.6 mmHg). More patients in the losartan group (50%) than in the placebo group (22%) showed a clinically meaningful reduction in TTPG at any timepoint; these effects seemed more marked in patients with higher baseline TTPG. There were no clear improvements in exercise capacity or symptoms.


CONCLUSION
In this 12-month pilot study, losartan 50 mg had no statistically significant beneficial effect on TTPG, exercise capacity or symptoms in pulmonary hypertension secondary to obstructive disease. A sub-group of patients with higher TTPG may benefit.
The impact of knowledge management on organisational performance

Knowledge management is a process that transforms individual knowledge into organisational knowledge. The aim of this paper is to show that through creating, accumulating, organising and utilising knowledge, organisations can enhance organisational performance. The impact of knowledge management practices on performance was empirically tested through structural equation modelling. The sample included 329 companies both in Slovenia and Croatia with more than 50 employees. The results show that knowledge management practices measured through. information technology, organisation and knowledge positively affect organisational performance. keywords: knowledge management maturity, information technology, organisational performance, structural equation modelling, survey research.
Intravenous lacosamide as treatment option in post-stroke non convulsive status epilepticus in the elderly: A proof-of-concept, observational study

PURPOSE
To evaluate the efficacy and safety of intravenously administered lacosamide (iv LCM) in post-stroke non convulsive status epilepticus (NCSE) in elderly patients.


METHODS
We enrolled 16 patients (7 M/9 F; 77 ± 7 years of age) with NCSE. iv LCM was used in all the patients as initial treatment (i.e. patients were directly started on LCM) at a loading dose of 400 mg over 30 min, followed by a mean maintenance dose of 400 mg per day. iv LCM was considered as effective in patients who experience no NCSE for 24 h following treatment, as evaluated by EEG recording and clinical observation.


RESULTS
LCM was effective in treating NCSE in eight of the sixteen patients in whom epileptic activity disappeared (7/8) or was significantly reduced (1/8) within 45-60 min after administration. None of these patients relapsed in the following 24 h. No adverse events were observed. A partial anterior circulation syndrome (PACS) was present in 10 patients while a total anterior circulation syndrome (TACS) in six.


CONCLUSIONS
This pilot study suggests that LCM exhibits safety and efficacy profiles which make it an optimal candidate as a first-choice drug against post-stroke NCSE in elderly patients. A prospective comparative trial is needed to confirm these preliminary data.
Tiotropium + olodaterol shows clinically meaningful improvements in quality of life.

BACKGROUND
Tiotropium + olodaterol improves lung function and symptoms compared to monotherapies in chronic obstructive pulmonary disease (COPD). The OTEMTO 1 and 2 studies investigated the effects of tiotropium + olodaterol on lung function and health-related quality of life compared to placebo in patients with moderate to severe COPD.


METHODS
In these two replicate, double-blind, parallel-group, placebo-controlled trials, patients were randomised to receive tiotropium + olodaterol 5/5 μg, 2.5/5 μg, tiotropium 5 μg or placebo for 12 weeks, via the Respimat(®) inhaler. Primary end points were St George's Respiratory Questionnaire (SGRQ) total score, forced expiratory volume in 1 s (FEV1) area under the curve from 0 to 3 h (AUC0-3) response and trough FEV1 response.


RESULTS
In OTEMTO 1 and 2, tiotropium + olodaterol 5/5 μg improved SGRQ total score by 4.89 (95% confidence interval [CI] -6.90, -2.88) and 4.56 (95% CI -6.50, -2.63) units versus placebo (both p < 0.0001), and 2.49 (95% CI -4.47, -0.51; p < 0.05) and 1.72 (95% CI -3.63, 0.19) units versus tiotropium 5 μg. Tiotropium + olodaterol 2.5/5 μg significantly improved SGRQ score compared to placebo. Both doses significantly improved FEV1 AUC0-3 response compared to placebo and tiotropium 5 μg. Tiotropium + olodaterol 5/5 and 2.5/5 μg also significantly improved trough FEV1 response compared to placebo (both studies) and separated from tiotropium 5 μg in OTEMTO 2. Adverse-event incidence was similar between treatment groups.


CONCLUSION
Tiotropium + olodaterol improved lung function and quality of life compared to placebo and tiotropium 5 μg.


TRIAL REGISTRATION
ClinicalTrials.gov: NCT01964352 and NCT02006732.
Factors associated with desistence and persistence of childhood gender dysphoria: a quantitative follow-up study.

OBJECTIVE
To examine the factors associated with the persistence of childhood gender dysphoria (GD), and to assess the feelings of GD, body image, and sexual orientation in adolescence.


METHOD
The sample consisted of 127 adolescents (79 boys, 48 girls), who were referred for GD in childhood (<12 years of age) and followed up in adolescence. We examined childhood differences among persisters and desisters in demographics, psychological functioning, quality of peer relations and childhood GD, and adolescent reports of GD, body image, and sexual orientation. We examined contributions of childhood factors on the probability of persistence of GD into adolescence.


RESULTS
We found a link between the intensity of GD in childhood and persistence of GD, as well as a higher probability of persistence among natal girls. Psychological functioning and the quality of peer relations did not predict the persistence of childhood GD. Formerly nonsignificant (age at childhood assessment) and unstudied factors (a cognitive and/or affective cross-gender identification and a social role transition) were associated with the persistence of childhood GD, and varied among natal boys and girls.


CONCLUSION
Intensity of early GD appears to be an important predictor of persistence of GD. Clinical recommendations for the support of children with GD may need to be developed independently for natal boys and for girls, as the presentation of boys and girls with GD is different, and different factors are predictive for the persistence of GD.
Cloud Computing Reference Architecture and Its Forensic Implications: A Preliminary Analysis

In this paper, researchers provide a preliminary analysis on the forensic implications of cloud computing reference architecture, on the segregation of duties of cloud actors in cloud investigations, forensic artifacts on all layers of cloud system stack, cloud actors interaction scenarios in cloud investigations, and forensic implications of all cloud deployment models. The analysis serves as feedback and input for integrating forensic considerations into cloud standardization processes from early stage, and specifies requirements and directions for further standardization efforts.
INTERNATIONAL DIVERSIFICATION , SUBSIDIARY PERFORMANCE , AND THE MOBILITY OF KNOWLEDGE RESOURCES

INTERNATIONAL DIVERSIFICATION, SUBSIDIARY PERFORMANCE, AND THE MOBILITY OF KNOWLEDGE RESOURCES YULIN FANG, MICHAEL WADE,* ANDREW DELIOS and PAUL W. BEAMISH 1 Faculty of Business, City University of Hong Kong, Hong Kong, China 2 Schulich School of Business, York University, Toronto, Ontario, Canada 3 Department of Business Policy, National University of Singapore, Singapore 4 Ivey Business School, University of Western Ontario, London, Ontario, Canada
R-FFT: Function Split at IFFT/FFT in Unified LTE CRAN and Cable Access Network

The remote-PHY (R-PHY) modular cable network for data over cable service interface specification (DOCSIS) service conducts the physical layer processing for the transmissions over the broadcast cable in a remote node. In contrast, the cloud radio access network (CRAN) for long-term evolution (LTE) cellular wireless services conducts all baseband physical layer processing in a central baseband unit and the remaining physical layer processing steps toward radio frequency (RF) transmission in remote nodes. Both DOCSIS and LTE are based on orthogonal frequency division multiplexing physical layer processing. We propose to unify cable and wireless cellular access networks by utilizing the hybrid fiber-coax (HFC) cable network infrastructure as fiber fronthaul network for cellular wireless services. For efficient operation of such a unified access network, we propose a novel remote-fast-Fourier transform (R-FFT) node that conducts the physical layer processing from the FFT module toward the RF transmission, whereby DOCSIS and LTE share a common FFT module. The frequency domain in-phase and quadrature (I/Q) symbols for both DOCSIS and LTE are transmitted over the fiber between remote node and cable headend, where the remaining physical layer processing is conducted. We further propose to cache repetitive quadrature amplitude modulation (QAM) symbols in the R-FFT node to reduce the fronthaul bitrate requirements and enable statistical multiplexing. We evaluate the fronthaul bitrate reductions achieved by R-FFT node caching, the fronthaul transmission bitrates arising from the unified DOCSIS and LTE service, and illustrate the delay implications of moving part of the cable R-PHY remote node physical layer processing to the headend. Overall, our evaluations indicate that the proposed R-FFT node can effectively support unified DOCSIS and LTE services over the HFC cable plant while substantially reducing the fronthaul bitrate requirements of the existing CRAN structures.
An ALU-based universal architecture for FIR filters

Traditionally, each time a new Finite Impulse Response (FIR) filter is required to design, a new algorithm have to be developed specially for the FIR filter. Furthermore, corresponding hardware architecture must be designed specially to meet the requirement of the FIR specifications. An Arithmetic Logic Unit (ALU) based universal FIR filter suitable for implementation in Field Programmable Gate Arrays (FPGA) is proposed in this paper. Rather than multiplier-accumulator based architecture used in conventional FIR, the proposed ALU architecture implements FIR functions by using accumulators and shift-registers controlled by the instructions of ROM. Furthermore, TDMA (Time Division Multiplexing Access) technique is employed to reduce chip size. In a case study, a 64-tap FIR filter is designed by the proposed architecture.
Robotic Grasping of Novel Objects using Vision

We consider the problem of grasping novel objects, specifically ones that are being seen for the first time through vision. Grasping a previously unknown object, one for which a 3-d model is not available, is a challenging problem. Further, even if given a model, one still has to decide where to grasp the object. We present a learning algorithm that neither requires, nor tries to build, a 3-d model of the object. Given two (or more) images of an object, our algorithm attempts to identify a few points in each image corresponding to good locations at which to grasp the object. This sparse set of points is then triangulated to obtain a 3-d location at which to attempt a grasp. This is in contrast to standard dense stereo, which tries to triangulate every single point in an image (and often fails to return a good 3-d model). Our algorithm for identifying grasp locations from an image is trained via supervised learning, using synthetic images for the training set. We demonstrate this approach on two robotic manipulation platforms. Our algorithm successfully grasps a wide variety of objects, such as plates, tape-rolls, jugs, cellphones, keys, screwdrivers, staplers, a thick coil of wire, a strangely shaped power horn, and others, none of which were seen in the training set. We also apply our method to the task of unloading items from dishwashers. 1
The von Willebrand inhibitor ARC1779 reduces cerebral embolization after carotid endarterectomy: a randomized trial.

BACKGROUND AND PURPOSE
Inhibition of von Willebrand factor offers a novel approach to prevention of stroke and myocardial ischemia but has not yet been demonstrated to show efficacy on clinically relevant end points. ARC1779 is an aptamer that inhibits the prothrombotic function of von Willebrand factor by binding to the A1 domain of von Willebrand factor and thereby blocking its interaction with glycoprotein. Phase 1 studies suggest it inhibits platelet aggregation with less increase in bleeding than conventional antiplatelet agents. The effect of ARC 1779 on cerebral emboli immediately after carotid endarterectomy was investigated in a randomized clinical trial.


METHODS
Patients undergoing carotid endarterectomy were randomized double-blind to ARC1779 or placebo administered intravenously. Transcranial Doppler recording, to detect cerebral embolic signals, was performed in the first 3 hours postoperatively. The primary end point was time to first embolic signals.


RESULTS
Thirty-six patients were recruited, 18 in each arm. The Kaplan-Meier median time to first embolic signals was 83.6 minutes for ARC1779 compared with 5.5 minutes for placebo. Using Cox proportional hazards embolic signals occurred statistically significantly later on ARC1779 (P=0.007). Reduced embolic signals counts were correlated with inhibition of von Willebrand factor activity (P=0.03). Increased perioperative bleeding and anemia were seen with ARC1779.


CONCLUSIONS
von Willebrand factor inhibition reduces thromboembolism in humans. It may play a role in treatment of stroke and myocardial ischemia. The extent to which bleeding complications occur in nonoperated patients needs to be assessed in further studies. Clinical Trial Registration- URL: http://clinicaltrials.gov. Unique identifier: NCT00742612.
Observational Skill-based Clinical Assessment tool for Resuscitation (OSCAR): Development and validation☆

AIM
The aim of the study reported here was to address the need to assess and train teamwork and non-technical skills in the context of Resuscitation. Specifically, we sought to develop a tool that is feasible to use and psychometrically sound to assess team behaviours during cardiac arrest resuscitation attempts.


METHODS
To ensure validity, reliability, and feasibility, the Observational Skill based Clinical Assessment tool for Resuscitation (OSCAR) was developed in 3 phases. A review of the literature leading to initial tool development was followed by an assessment of face and content validity, and finally a thorough reliability assessment, using Cronbach's α to assess internal consistency and intraclass correlation to assess inter-rater reliability.


RESULTS
OSCAR was developed methodically, and tested for face and content validity. Cronbach's α results ranged from 0.736 to 0.965 demonstrating high internal consistency, and intraclass correlation results ranged from 0.652 to 0.911, all of which are strongly significant and indicate good inter-rater reliability.


CONCLUSION
On the basis of our results, we conclude that OSCAR is psychometrically robust, scientifically sound, and clinically relevant. We have developed the Observational Skill-based Clinical Assessment tool for Resuscitation (OSCAR) for the assessment of non-technical skills in Resuscitation teams. We propose the use of this tool in simulation and real Cardiac Arrest Resuscitation attempts to assess, guide and train non-technical skills to team members, to improve patient safety and maximise the chances of successful resuscitation.
Web Content Categorization Using Link Information

Document categorization is one of the foundational problems in (web) information retrieval. Even though web documents are hyperlinked, most proposed classification techniques take little advantage of the link structure and rely primarily on text features, as it is not immediately clear how to make link information intelligible to supervised machine learning algorithms. This paper introduces a link-based approach to classification, which can be used in isolation or in conjunction with text-based classification. Various large-scale experimental results indicate that link-based classification is on par with text-based classification, and the combination of the two offers the best of both worlds.
Quantum physics: Observations turn up the heat

The idea that observers can influence what they observe has a history that stretches back beyond quantum physics. That we can affect how a system heats up and cools down simply by probing it is a new twist.
Volatility puzzles: a simple framework for gauging return-volatility regressions

This paper provides a simple theoretical framework for assessing the empirical linkages between returns and realized and implied volatilities. First, we show that whereas the volatility feedback effect as measured by the sign of the correlation between contemporaneous return and realized volatility depends importantly on the underlying structural model parameters, the correlation between return and implied volatility is unambiguously positive for all reasonable parameter configurations. Second, the asymmetric response of current volatility to lagged negative and positive returns, typically referred to as the leverage effect, is always stronger for implied than realized volatility. Third, implied volatilities generally provide downward biased forecasts of subsequent realized volatilities. Our results help explain previous findings reported in the extant empirical literature, and is further corroborated by new estimation results for a sample of monthly returns and implied and realized volatilities for the S&P500 aggregate market index. JEL Classification: G12, C51, C22.