LLukas22/scidocs huggingface dataset:
T3b-T4 breast cancer: factors affecting results in combined modality treatments

Two hundred and seventy-seven consecutive patients with T3b-T4 breast cancer referred to the Milan Cancer Institute between 1973 and 1980 were treated with a combined modality approach. Chemotherapy (CT) consisted of AV, i.e. adriamycin (60–75 mg/m2 day 1) and vincristine (1·2 mg/m2 days 1 and 8) and was given for three to four cycles prior to local regional modality. Local-regional treatment consisted of either radiotherapy (RT) in 198 patients or surgery (S) in 79 women. Additional chemotherapy was then administered to a total of 205 patients. In the absence of distant metastases, frequency of good local control was significantly inferior in patients given CT + RT (63·9 per cent) compared to those treated with CT + RT + CT (75·4 per cent) and CT + S + CT (82·3 per cent, P=0·033). Also freedom from progression (FFP) and overall survival (SURV) were significantly superior in the groups receiving more prolonged chemotherapy treatment compared to patients treated with CT + RT (FFP: P·0001; SURV: P=0·002). None of the variables examined was able to affect the response rate, while axillary nodal status and tumor size played a major role in the duration of FFP and SURV. Our findings indicate that a more aggressive treatment is needed to improve current results in this stage of disease. To overcome the problem of local-regional recurrence, treatment should probably begin with cytoreductive surgery followed by postoperative radiotherapy in all patients with the exception of those having inflammatory carcinoma. Systemic treatment should then be delivered to control distant micrometastases.
Portomesenteric thrombosis following laparoscopic bariatric surgery: incidence, patterns of clinical presentation, and etiology in a bariatric patient population.

OBJECTIVE
To describe the incidence of, the patterns of clinical presentation of, and the reasons for portomesenteric vein thrombosis among patients who underwent laparoscopic bariatric surgery.


DESIGN
Retrospective, multicenter study.


SETTING
Six academic bariatric centers.


PATIENTS
Morbidly obese patients diagnosed with portomesenteric vein thrombosis following laparoscopic bariatric surgery between January 2007 and June 2012.


MAIN OUTCOME MEASURES
Clinical presentation, diagnostic measures used, treatments employed, outcome, and hematologic workup of patients.


RESULTS
Of 5706 patients who underwent laparoscopic bariatric surgery, 17 (0.3%) had portomesenteric vein thrombosis, 16 after sleeve gastrectomy and 1 following adjustable gastric banding. Seven patients were women, the mean age was 38 years, and the mean body mass index was 44.3. The median time to presentation was 10.1 days, and the median time to diagnosis was 11.7 days. New-onset epigastric pain was present in all patients, whereas other signs and symptoms were sporadically found. Computed tomography was performed and was diagnostic in 16 cases. Ultrasonography was used for 9 patients, and positive results were found for 8 of these patients. Patients were treated by anticoagulation with subcutaneous low-molecular-weight heparin (n = 15) or intravenous heparin (n = 2), followed by warfarin sodium. One patient underwent transhepatic portal infusion of streptokinase. Three patients required surgery: laparoscopic splenectomy due to infarct and abscess for 1 patient and laparotomy for 2 patients (with necrotic small-bowl resection for 1 of these patients). There were no deaths.


CONCLUSIONS
Portomesenteric vein thrombosis is rare after laparoscopic bariatric surgery. Familiarity with this dangerous entity is important. Prompt diagnosis and care, initiated by a high index of suspicion, is crucial.
University student counseling and mental health in the United States: Trends and challenges

This article reviews the status of the delivery of counseling and mental health services at colleges and universities in the United States. It provides an overview of historical and current trends of student mental health concerns and of the ways in which campus counseling services have responded to these challenges. Data from several sources are referenced to demonstrate both the increasing numbers of students seeking counseling services and the increasing severity of their concerns. Examples are provided for how these trends have influenced the delivery of counseling services and how they are changing college and university communities.
On median nature and enumerative properties of Fibonacci-like cubes

Fibonacci cubes, extended Fibonacci cubes, and Lucas cubes are induced subgraphs of hypercubes 9 defined in terms of Fibonacci strings. It is shown that all these graphs are median. Several enumeration results on the number of their edges and squares are obtained. Some identities involving Fibonacci 11 and Lucas numbers are also presented. © 2005 Published by Elsevier B.V. 13
Prediction analysis of solid waste generation based on grey fuzzy dynamic modeling

Successful planning of a solid waste management system depends critically on the prediction accuracy of solid waste generation. But the prediction condition of generation trend in many developing countries is quite different from those in developed countries. The lack of sampling and analysis in many developing countries due to insufficient budget and unavailable management task force has resulted in a situation where the historical record of solid waste generation and composition can never be completed in the long term. To effectively handle these problems with only limited samples and fulfil the prediction analysis of solid waste generation with reasonable accuracy, a special analytical technique must be developed and applied before the subsequent system planning for urban solid waste management is carried out. This study presents a new theory — grey fuzzy dynamic modeling — for the prediction of solid waste generation in the urban area based on a set of limited samples. The practical implementation has been accessed by a case study in the city of Tainan in Taiwan. It shows that such a new forecasting technique may achieve better prediction accuracy than those of the conventional grey dynamic model, least-squares regression method, and the fuzzy goal regression technique. © 2000 Elsevier Science B.V. All rights reserved.
The role of dynamic geometry software in the process of learning: GeoGebra example about triangles

This study is about using GeoGebra and its effect on eight grade students’ achievements for the subjects of triangles. The study is conducted in the fall semester of 2009-2010 academic year. Two eighth grade classes from a primary school were selected as experiment and control groups. Before the classroom activities, a pre test which covered questions about seventh grade objectives was applied to the both groups to determine the students’ attainment level. A two weeks course was planned in accordance with the official course curriculum for the experiment group. The course contained GeoGebra activities and practices about the stated objectives. The planned and GeoGebra constructed activities which demand effective use of GeoGebra for this grade shared with the students during the learning and teaching process. Simultaneously, the control group continued their formal teaching and learning procedure. After the two weeks, a post test was applied to the both groups simultaneously. The post test contained questions about the stated objectives for the eighth grade. Furthermore, one month after the application a recall test was applied to both groups as well. Possible comparisons between the tests and the groups were performed. The results show that dynamic software (GeoGebra) has positive effects on students' learning and achievement. It has also been observed that it improves students’ motivation with positive impact.
Hip Muscle Strength Predicts Noncontact Anterior Cruciate Ligament Injury in Male and Female Athletes: A Prospective Study.

BACKGROUND
Prospective studies have reported that abnormal movement patterns at the trunk, hip, and knee are associated with noncontact anterior cruciate ligament (ACL) injuries. Impaired hip strength may underlie these abnormal movement patterns, suggesting that diminished hip strength may increase the risk of noncontact ACL injury.


PURPOSE
To determine whether baseline hip strength predicts future noncontact ACL injury in athletes.


STUDY DESIGN
Case-control study; Level of evidence, 3.


METHODS
Before the start of the competitive season, isometric hip strength (external rotation and abduction) was measured bilaterally by use of a handheld dynamometer in 501 competitive athletes (138 female and 363 male athletes) participating in various sports. During the sport season, ACL injury status was recorded, and injured athletes were further classified based on the mechanism of injury (noncontact vs contact). After the season, logistic regression was used to determine whether baseline hip strength predicted future noncontact ACL injury. Receiver operating characteristic (ROC) curves were constructed independently for each strength measure to determine the clinical cutoff value between a high-risk and low-risk outcome.


RESULTS
A total of 15 noncontact ACL injuries were confirmed (6 females, 9 males), for an overall annual incidence of 3.0% (2.5% for males, 4.3% for females). Baseline hip strength measures (external rotation and abduction) were significantly lower in injured athletes compared with noninjured athletes (P = .003 and P < .001, respectively). Separate logistic regression models indicated that impaired hip strength increased future injury risk (external rotation: odds ratio [OR] = 1.23 [95% CI, 1.08-1.39], P = .001; abduction: OR = 1.12 [95% CI, 1.05-1.20], P = .001). Clinical cutoffs to define high risk were established as external rotation strength ≤20.3% BW (percentage of body weight) or abduction strength ≤35.4% BW.


CONCLUSION
Measures of preseason isometric hip abduction and external rotation strength independently predicted future noncontact ACL injury status in competitive athletes. The study data suggest that screening procedures to assess ACL injury risk should include an assessment of isometric hip abduction and/or external rotation strength.
An experiment on an ontology-based support approach for process modeling

Context: Recent research discusses the use of ontologies, dictionaries and thesaurus as a means to improve activity labels of process models. However, the trade-off between quality improvement and extra effort is still an open question. It is suspected that ontology-based support could require additional effort for the modeler. Objective: In this paper, we investigate to which degree ontology-based support potentially increases the effort of modeling. We develop a theoretical perspective grounded in cognitive psychology, which leads us to the definition of three design principles for appropriate ontology-based support. The objective is to evaluate the design principles through empirical experimentation. Method: We tested the effect of presenting relevant content from the ontology to the modeler by means of a quantitative analysis. We performed controlled experiments using a prototype, which generates a simplified and context-aware visual representation of the ontology. It logs every action of the process modeler for analysis. The experiment refers to novice modelers and was performed as between-subject design with vs. without ontology-based support. It was carried out with two different samples. Results: Part of the effort-related variables we measured showed significant statistical difference between the group with and without ontology-based support. Overall, for the collected data, the ontology support achieved good results. Conclusion: We conclude that it is feasible to provide ontology-based support to the modeler in order to improve process modeling without strongly compromising time consumption and cognitive effort.
Serum N-Glycan Profiling Predicts Prognosis in Patients Undergoing Hemodialysis

BACKGROUND
The aim of this study is to evaluate the usefulness of serum N-glycan profiling for prognosis in hemodialysis patients.


METHODS
Serum N-glycan analysis was performed in 100 hemodialysis patients in June 2008 using the glycoblotting method, which allows high-throughput, comprehensive, and quantitative N-glycan analysis. All patients were longitudinally followed up for 5 years. To evaluate the independent predictors for prognosis, patients' background, blood biochemistry, and N-glycans intensity were analyzed using Cox regression multivariate analysis. Selected N-glycans and independent factors were evaluated using the log-rank test with the Kaplan-Meier method to identify the predictive indicators for prognosis. Each patient was categorized according to the number of risk factors to evaluate the predictive potential of the risk criteria for prognosis.


RESULTS
In total, 56 N-glycan types were identified in the hemodialysis patients. Cox regression multivariate analysis showed cardiovascular events, body mass index, maximum intima media thickness, and the serum N-glycan intensity of peak number 49 were predictive indicators for overall survival. Risk classification according to the number of independent risk factors revealed significantly poor survival by increasing the number of risk factors.


CONCLUSIONS
Serum N-glycan profiling may have a potential to predict prognosis in patients undergoing hemodialysis.
Atorvastatin Reduces the Incidence of Postoperative Atrial Fibrillation in Statin-Naive Patients Undergoing Isolated Heart Valve Surgery: A Double-Blind, Placebo-Controlled Randomized Trial.

BACKGROUND
Atorvastatin has been demonstrated to reduce the incidence of postoperative atrial fibrillation (POAF) in patients undergoing cardiac surgery, but its effect on isolated heart valve surgery is unknown.


METHODS
In a randomized, double-blinded, placebo-controlled trial, 58 patients who underwent isolated heart valve surgery supported by on-pump cardiopulmonary bypass were randomly assigned to receive either placebo (n = 29) or 40 mg of atorvastatin once daily starting 3 days preoperatively and continuing within 5 days postoperatively (n = 29). A continuous monitoring tool and an electrocardiographic Holter monitoring were used for detecting the POAF (Clinical Trial Registration: www.clinicaltrials.gov; Unique Identifier: NTC02084069).


RESULTS
The patients' median age was 49 years, and 67% were female. In all, 6 (21%) and 13 (45%) cases of POAF were observed in the atorvastatin and placebo groups, respectively (P = .050). The duration of AF before re-establishment of sinus rhythm was significantly lower in the atorvastatin group than in the placebo group (median of 70 vs 132 minutes, P = .026). The lengths of intensive care unit and hospital stay were comparable between the groups. The increase in postoperative white blood cell count was significantly lower in the atorvastatin group than in the placebo group (median of 1.5 vs 2.3 × 10(3)/µL, respectively, P = .019). After adjustment, the atorvastatin treatment was associated with a decrease in the risk of developing POAF (odds ratio 0.122, 95% confidence interval 0.027-0.548, P = .006).


CONCLUSION
Perioperative treatment with 40 mg of atorvastatin is useful to decrease the incidence of POAF in the statin-naive patients undergoing isolated heart valve surgery.
Improving Sentiment Analysis in Arabic Using Word Representation

The complexities of Arabic language in morphology, orthography and dialects makes sentiment analysis for Arabic more challenging. Also, text feature extraction from short messages like tweets, in order to gauge the sentiment, makes this task even more difficult. In recent years, deep neural networks were often employed and showed very good results in sentiment classification and natural language processing applications. Word embedding, or word distributing approach, is a current and powerful tool to capture together the closest words from a contextual text.In this paper, we describe how we construct Word2Vec models from a large Arabic corpus obtained from ten newspapers in different Arab countries. By applying different machine learning algorithms and convolutional neural networks with different text feature selections, we report improved accuracy of sentiment classification (91%-95%) on our publicly available Arabic language health sentiment dataset [1].
A Changing Landscape of Physician Quality Reporting: Analysis of Patients’ Online Ratings of Their Physicians Over a 5-Year Period

BACKGROUND
Americans increasingly post and consult online physician rankings, yet we know little about this new phenomenon of public physician quality reporting. Physicians worry these rankings will become an outlet for disgruntled patients.


OBJECTIVE
To describe trends in patients' online ratings over time, across specialties, to identify what physician characteristics influence online ratings, and to examine how the value of ratings reflects physician quality.


METHODS
We used data from RateMDs.com, which included over 386,000 national ratings from 2005 to 2010 and provided insight into the evolution of patients' online ratings. We obtained physician demographic data from the US Department of Health and Human Services' Area Resource File. Finally, we matched patients' ratings with physician-level data from the Virginia Medical Board and examined the probability of being rated and resultant rating levels.


RESULTS
We estimate that 1 in 6 practicing US physicians received an online review by January 2010. Obstetrician/gynecologists were twice as likely to be rated (P < .001) as other physicians. Online reviews were generally quite positive (mean 3.93 on a scale of 1 to 5). Based on the Virginia physician population, long-time graduates were more likely to be rated, while physicians who graduated in recent years received higher average ratings (P < .001). Patients gave slightly higher ratings to board-certified physicians (P = .04), those who graduated from highly rated medical schools (P = .002), and those without malpractice claims (P = .1).


CONCLUSION
Online physician rating is rapidly growing in popularity and becoming commonplace with no evidence that they are dominated by disgruntled patients. There exist statistically significant correlations between the value of ratings and physician experience, board certification, education, and malpractice claims, suggesting a positive correlation between online ratings and physician quality. However, the magnitude is small. The average number of ratings per physician is still low, and most rating variation reflects evaluations of punctuality and staff. Understanding whether they truly reflect better care and how they are used will be critically important.
Reversible fault-tolerant logic

It is now widely accepted that the CMOS technology implementing irreversible logic may hit a scaling limit beyond 2016, and that the increased power dissipation is a major limiting factor. Reversible computing can potentially require arbitrarily small amounts of energy. Recently several nano-scale devices which have the potential to scale, and which naturally perform reversible logic, have emerged. This paper addresses several fundamental issues that need to be addressed before any nano-scale reversible computing systems can be realized, including reliability and performance trade-offs and architecture optimization. Many nano-scale devices are limited to only near neighbor interactions, requiring careful optimization of circuits. We provide efficient fault-tolerant (FT) circuits when restricted to both 2D and 1D. Finally, we compute bounds on the entropy (and hence, heat) generated by our FT circuits and provide quantitative estimates on how large can we make our circuits before we lose any advantage over irreversible computing.
Myths of the English

1. Gilbert & Sullivan:. The Making and Un-making of a British 'Tradition': David Cannadine. 2. Speaking with Double Tongue:. Mother Goose and the Old Wives' Tale: Marina Warner. 3. The Fifth of November Remembered: David Cressy. 4. The Tramp: M. A. Crowther. 5. The English Bobby: . An Indulgent Tradition: Clive Emsley. 6. Name upon Name:. The Great War and Remembrance: Robert Bushaway. 7. Discretion, Sobriety and Wisdom:. The Teacher in Children's Books: Margaret Kinnell. 8. Authority in the University:. Balliol and Newnham in Loco Parentis: Reba Soffer. 9. The Gentleman and the Hero:. Wellington and Napoleon in the 19th Century: Iain Pears. 10. Britishness and Portraiture: Trudi Prescott Nuding. Notes on Contributors. Index.
Initial and long-term evaluation of patients with Alzheimer’s after hospitalization in cognitive and behavioural units: the EVITAL study design

BACKGROUND
Alzheimer's disease and related disorders are characterized by cognitive impairment associated with behavioral and psychological symptoms of dementia. These symptoms have significant consequences for both the patient and his family environment. While risk factors for behavioral disorders have been identified in several studies, few studies have focused on the evolution of these disorders. Moreover, it is important to identify factors linked to the long-term evolution of behavioral disorders, as well as patients' and caregivers' quality of life. Our purpose is to present the methodology of the EVITAL study, which primary objective is to determine the factors associated with the evolution of behavioral disorders among patients with Alzheimer's disease and related disorders during the year following their hospitalization in cognitive and behavioral units. Secondary objectives were 1) to assess the factors related to the evolution of behavioral disorders during hospitalization in cognitive and behavioral units; 2) to identify the factors linked to patients' and caregivers' quality of life, as well as caregivers' burden; 3) to assess the factors associated with rehospitalization of the patients for behavioral disorders in the year following their hospitalization in cognitive and behavioral units.


METHOD/DESIGN
A multicenter, prospective cohort of patients with Alzheimer's disease and related disorders as well as behavioral disorders who are hospitalized in cognitive and behavioral units. The patients will be included in the study for a period of 24 months and followed-up for 12 months. Socio-demographic and environmental data, behavioral disorders, medications, patients and caregivers quality of life as well as caregivers burden will be assessed throughout hospitalization in cognitive and behavioral units. Follow-up will be performed at months 3, 6 and 12 after hospitalization. Socio-demographic and environmental data, behavioral disorders, medications, patients and caregivers quality of life, unplanned rehospitalization as well as caregivers burden will also be assessed at each follow-up interview.


DISCUSSION
The present study should help better identify the factors associated with reduction or stabilization of the behavioral and psychological symptoms of dementia in patients with Alzheimer's disease. It could therefore help clinicians to better manage these symptoms.


TRIAL REGISTRATION
Clinical Trials NCT01901263. Registered July 9, 2013.
Skill Discovery in Continuous Reinforcement Learning Domains using Skill Chaining

We introduce a skill discovery method for reinforcement learning in continuous domains that constructs chains of skills leading to an end-of-task reward. We demonstrate experimentally that it creates appropriate skills and achieves performance benefits in a challenging continuous domain.