LLukas22/scidocs huggingface dataset:
Drug treatment or alleviating the negative consequences of imprisonment? A critical view of prison-based drug treatment in Denmark.

BACKGROUND
The availability of prison-based drug treatment has increased markedly throughout Europe over the last 15 years in terms of both volume and programme diversity. However, prison drug treatment faces problems and challenges because of the tension between ideologies of rehabilitation and punishment.


METHODS
This article reports on a study of four cannabis treatment programmes and four psychosocial drug treatment programmes in four Danish prisons during 2007. The data include the transcripts of 22 semi-structured qualitative interviews with counsellors and prison employees, prison statistics, and information about Danish laws and regulations.


RESULTS
These treatment programmes reflect the 'treatment guarantee' in Danish prisons. However, they are simultaneously embedded in a new policy of zero tolerance and intensified disciplinary sanctions. This ambivalence is reflected in the experiences of treatment counsellors: reluctantly, they feel associated with the prison institution in the eyes of the prisoners; they experience severe opposition from prison officers; and the official goals of the programmes, such as making clients drug free and preparing them for a life without crime, are replaced by more pragmatic aims such as alleviating the pain of imprisonment felt by programme clients.


CONCLUSION
The article concludes that at a time when prison-based drug treatment is growing, it is crucial that we thoroughly research and critically discuss its content and the restrictions facing such treatment programmes. One way of doing this is through research with counsellors involved in delivering drug treatment services. By so doing, the programmes can become more pragmatic and focused, and alternatives to prison-based drug treatment can be seriously considered.
Double circuit transmission line Fault Distance Location using Artificial Neural Network

Distance relays used for protection of transmission lines have problems of under-reach, over-reach and maloperation due to high impedance faults. Further the problem is compounded when the distance relays are used for protection of double circuit transmission lines due to effect of zero sequence mutual coupling. Different types of faults on a protected transmission line should be located correctly. This paper presents a single neural network for fault distance location for all the ten types of faults (3 LG, 3 LLG, 3 LL, 1 LLL) in both the circuits of a double circuit transmission line fed from sources at both the end. This technique uses only one end data and accurate fault distance location is achieved after one cycle from the inception of fault. The proposed Artificial Neural Network (ANN) based Fault Distance Locator uses fundamental components of three phase current signals of both the circuits & three phase voltage signals to learn the hidden relationship in the input patterns. An improved performance is obtained once the neural network is trained suitably, thus performing correctly when faced with different system parameters and conditions i.e. varying fault type, fault location, fault resistance, fault inception angle, presence of mutual coupling and remote source infeed.
Elevational shifts, biotic homogenization and time lags in vegetation change during 40 years of climate warming

changes (e.g. meters of elevational distribution shift) with expectations based on the magnitude of environmental change itself over the same time period (e.g. meters of elevational shift in isotherms) (Bertrand et al. 2011, Devictor et al. 2012, Feeley et al. 2013). Many studies have reported both substantial lags in response to climate warming, for example with observed changes  50 % of those expected (Davis 1986, Bertrand et al. 2011, Devictor et al. 2012), as well as a fairly close match between observed and expected ecological changes. For example, Beckage et al. (2008) suggested that the deciduous-boreal ecotone in mountains of northeastern North America had shifted upward in elevations more or less in concert with regional climate warming. It is unclear whether this apparent rapid ecological tracking of climate change applies more broadly to the full suite of plants in these systems. Studies in which long-term vegetation change has been attributed to climate warming have found both increases and decreases in local plant species richness (Damschen et al. 2010, Danby et al. 2011, Vellend et al. 2013a). With high elevations typically characterized by relatively low richness, increased richness is expected, although a priori expectations for lower elevations are more diffi cult to derive. Although many studies have explored changes in alpha diversity in Ecography 38: 546–555, 2015 doi: 10.1111/ecog.01131 © 2014 Th e Authors. Ecography © 2014 Nordic Society Oikos Subject Editor: Kenneth Feeley. Editor-in-Chief: Miguel Ara ú jo. Accepted 26 August 2014
Rationale and methodology for a multicentre randomised trial of fibrinolysis for pulmonary embolism that includes quality of life outcomes.

BACKGROUND
Submassive pulmonary embolism (PE) has a low mortality rate but can degrade functional capacity.


OBJECTIVE
The present study aims to provide rationale, methodology, and initial findings of a multicentre, randomised trial of fibrinolysis for PE that used a composite end-point, including quality of life measures.


METHODS
This investigator-initiated study was funded by a contract between a corporate partner and the investigator's hospital (the prime site). The investigator was the Food and Drug Administration (FDA) sponsor. The prime site subcontracted, indemnified, and trained consortia members. Consenting, normotensive patients with PE and right ventricular strain (by echocardiography or biomarkers) received low-molecular-weight heparin and random assignment to a single bolus of tenecteplase or placebo in double-blinded fashion. The outcomes were: (i) in-hospital rate of intubation, vasopressor support, and major haemorrhage, or (ii) at 90 days, death, recurrent PE, or composite that defined poor quality of life (echocardiography, 6 min walk test and surveys). The planned sample size was n = 200.


RESULTS
Eight sites enrolled 87 patients over 5 years. The ratio of patients screened for each enrolled was 7.4 to 1, equating to 11 h screening time per patient enrolled. Primary barrier to enrolment was the cost of screening. Two patients died (2.5%, 95%CI [0-8%]), one developed shock, but 18 (22%, 95%CI: [13-30%]) had a poor quality of life.


CONCLUSIONS
An investigator-initiated, FDA-regulated, multicentre trial of fibrinolysis for submassive PE was conducted, but was limited by screening costs and a low mortality rate. Quality of life measurements might represent a more important patient-centred end-point.
Neurological development of 5-year-old children receiving a low-saturated fat, low-cholesterol diet since infancy: A randomized controlled trial.

CONTEXT
Early childhood introduction of nutritional habits aimed at atherosclerosis prevention is compatible with normal growth, but its effect on neurological development is unknown.


OBJECTIVE
To analyze how parental counseling aimed at keeping children's diets low in saturated fat and cholesterol influences neurodevelopment during the first 5 years of life.


DESIGN
Randomized controlled trial conducted between February 1990 and November 1996.


SETTING
Outpatient clinic of a university department in Turku, Finland.


PARTICIPANTS
A total of 1062 seven-month-old infants and their parents, recruited at well-baby clinics between 1990 and 1992. At age 5 years, 496 children still living in the city of Turku were available to participate in neurodevelopmental testing.


INTERVENTION
Participants were randomly assigned to receive individualized counseling aimed at limiting the child's fat intake to 30% to 35% of daily energy, with a saturated:monounsaturated:polyunsaturated fatty acid ratio of 1:1:1 and a cholesterol intake of less than 200 mg/d (n = 540) or usual health education (control group, n = 522).


MAIN OUTCOME MEASURES
Nutrient intake, serum lipid concentrations, and neurological development at 5 years, among children in the intervention vs control groups.


RESULTS
Absolute and relative intakes of fat, saturated fatty acids, and cholesterol among children in the intervention group were markedly less than the respective values of control children. Mean (SD) percentages of daily energy at age 5 years for the intervention vs control groups were as follows: for total fat, 30.6% (4.5%) vs 33.4% (4.4%) (P<. 001); and for saturated fat, 11.7% (2.3%) vs 14.5% (2.4%) (P<.001). Mean intakes of cholesterol were 164.2 mg (60.1 mg) and 192.5 mg (71. 9 mg) (P<.001) for the intervention and control groups, respectively. Serum cholesterol concentrations were continuously 3% to 5% lower in children in the intervention group than in children in the control group. At age 5 years, mean (SD) serum cholesterol concentration of the intervention group was 4.27 (0.63) mmol/L (165 [24] mg/dL) and of the control group, 4.41 (0.74) mmol/L (170 [29] mg/dL) (P =.04). Neurological development of children in the intervention group was at least as good as that of children in the control group. Relative risks for children in the intervention group to fail tests of speech and language skills, gross motor functioning plus perception, and visual motor skills were 0.95 (90% confidence interval [CI], 0.60-1.49), 0.95 (90% CI, 0.58-1.55), and 0.65 (90% CI, 0.39-1.08), respectively (P =.85,.86, and.16, respectively, vs control children).


CONCLUSION
Our data indicate that repeated child-targeted dietary counseling of parents during the first 5 years of a child's life lessens age-associated increases in children's serum cholesterol and is compatible with normal neurological development. JAMA. 2000;284:993-1000
Associations between Vitamin D Status and Type 2 Diabetes Measures among Inuit in Greenland May Be Affected by Other Factors.

OBJECTIVE
Epidemiological studies have provided evidence of an association between vitamin D insufficiency and type 2 diabetes. Vitamin D levels have decreased among Inuit in Greenland, and type 2 diabetes is increasing. We hypothesized that the decline in vitamin D could have contributed to the increase in type 2 diabetes, and therefore investigated associations between serum 25(OH)D3 as a measure of vitamin D status and glucose homeostasis and glucose intolerance in an adult Inuit population.


METHODS
2877 Inuit (≥18 years) randomly selected for participation in the Inuit Health in Transition study were included. Fasting- and 2hour plasma glucose and insulin, C-peptide and HbA1c were measured, and associations with serum 25(OH)D3 were analysed using linear and logistic regression. A subsample of 330 individuals who also donated a blood sample in 1987, were furthermore included.


RESULTS
After adjustment, increasing serum 25(OH)D3 (per 10 nmol/L) was associated with higher fasting plasma glucose (0.02 mmol/L, p = 0.004), 2hour plasma glucose (0.05 nmol/L, p = 0.002) and HbA1c (0.39%, p<0.001), and with lower beta-cell function (-1.00 mmol/L, p<0.001). Serum 25(OH)D3 was positively associated with impaired fasting glycaemia (OR: 1.08, p = 0.001), but not with IGT or type 2 diabetes.


CONCLUSIONS
Our results did not support an association between low vitamin D levels and risk of type 2 diabetes. Instead, we found weak positive associations between vitamin D levels and fasting- and 2hour plasma glucose levels, HbA1c and impaired fasting glycaemia, and a negative association with beta-cell function, underlining the need for determination of the causal relationship.
A general two-phase debris flow model

[1] This paper presents a new, generalized two-phase debris flow model that includes many essential physical phenomena. The model employs the Mohr-Coulomb plasticity for the solid stress, and the fluid stress is modeled as a solid-volume-fraction-gradient-enhanced non-Newtonian viscous stress. The generalized interfacial momentum transfer includes viscous drag, buoyancy, and virtual mass. A new, generalized drag force is proposed that covers both solid-like and fluid-like contributions, and can be applied to drag ranging from linear to quadratic. Strong coupling between the solidand the fluid-momentum transfer leads to simultaneous deformation, mixing, and separation of the phases. Inclusion of the non-Newtonian viscous stresses is important in several aspects. The evolution, advection, and diffusion of the solid-volume fraction plays an important role. The model, which includes three innovative, fundamentally new, and dominant physical aspects (enhanced viscous stress, virtual mass, generalized drag) constitutes the most generalized two-phase flow model to date, and can reproduce results from most previous simple models that consider singleand two-phase avalanches and debris flows as special cases. Numerical results indicate that the model can adequately describe the complex dynamics of subaerial two-phase debris flows, particle-laden and dispersive flows, sediment transport, and submarine debris flows and associated phenomena.
Alley cropping on an Ultisol in subhumid Benin. Part 1: Long-term effect on maize, cassava and tree productivity

In southern Benin, West Africa, two alley cropping systems were studied from 1986 to 1992. Yield development was followed in a maize and cassava crop rotation vs. intercropping system, with alleys of Leucaena leucocephala (Lam.) de Wit and Cajanus cajan (L.) Millsp. vs. a no-tree control, with and without NPK fertiliser. Without alleys, NPK fertilisation maintained high yield levels of 2–3 t maize dry grain plus 4–6 t ha−1 cassava root DM in intercropping, 3–4 t ha−1 maize and 6–10 t ha−1 cassava in solercropping. Without NPK, final yields seemed to stabilise at about 1 t maize plus 2 t cassava in intercropping and twice as much in each solecrop. Alley cropping induced significant yield increases by about 50% with both tree species in unfertilised, intercropped maize, and with Cajanus in fertilised, solecropped cassava. In monetary terms, the NPK-fertiliser response of stabilised yields was significant for all treatments except the solecropped Leucaena alleys. It is concluded that on Ultisols with low nutrient status in the upper rooting zone, alley cropping with low-competitive tree species may improve food crop yields but the greatest monetary output is achieved by intercropping with mineral fertiliser independent of the presence or absence of an agroforestry component.
Effect of exercise on blood pressure in older persons: a randomized controlled trial.

BACKGROUND
Because of age-related differences in the cause of hypertension, it is uncertain whether current exercise guidelines for reducing blood pressure (BP) are applicable to older persons. Few exercise studies in older persons have evaluated BP changes in relation to changes in body composition or fitness.


METHODS
This was a 6-month randomized controlled trial of combined aerobic and resistance training; controls followed usual care physical activity and diet advice. Participants (aged 55-75 years) had untreated systolic BP (SBP) of 130 to 159 mm Hg or diastolic BP (DBP) of 85 to 99 mm Hg.


RESULTS
Fifty-one exercisers and 53 controls completed the trial. Exercisers significantly improved aerobic and strength fitness, increased lean mass, and reduced general and abdominal obesity. Mean decreases in SBP and DBP, respectively, were 5.3 and 3.7 mm Hg among exercisers and 4.5 and 1.5 mm Hg among controls (P < .001 for all). There were no significant group differences in mean SBP change from baseline (-0.8 mm Hg; P=.67). The mean DBP reduction was greater among exercisers (-2.2 mm Hg; P=.02). Aortic stiffness, indexed by aortofemoral pulse-wave velocity, was unchanged in both groups. Body composition improvements explained 8% of the SBP reduction (P = .006) and 17% of the DBP reduction (P<.001).


CONCLUSIONS
A 6-month program of aerobic and resistance training lowered DBP but not SBP in older adults with mild hypertension more than in controls. The concomitant lack of improvement in aortic stiffness in exercisers suggests that older persons may be resistant to exercise-induced reductions in SBP. Body composition improvements were associated with BP reductions and may be a pathway by which exercise training improves cardiovascular health in older men and women.
Ultrasonographic features in symptomatic osteoarthritis of the knee and relation with pain.

OBJECTIVE
Radiographic knee OA is moderately associated with pain. As OA is a disease of the entire joint, ultrasonography visualizing cartilage and soft tissue structures might provide more insight into the complex process of pain in knee OA. The objective of this study was to investigate the cross-sectional association between US findings and pain in knee OA.


METHODS
In this observational study, 180 patients fulfilling the ACR clinical criteria for knee OA underwent US examination of the most symptomatic knee. The US protocol comprised assessment of synovial hypertrophy, joint effusion, infrapatellar bursitis and Baker's cyst, medial meniscus protrusion and cartilage thickness. To evaluate the association between US features and pain (Numerated Rating Scale from 0 to 10 and the Knee Injury and Osteoarthritis Outcome Score pain subscale), regression analysis was performed.


RESULTS
In regression analysis, no association between US or clinical or demographic features and the level of knee pain was found.


CONCLUSION
In this cohort, no association between US features and the degree of knee pain was found. Despite the attractiveness of US (easy accessible, inexpensive and no radiation involvement) and the fact that previous research suggested otherwise, it remains uncertain which part of pain in knee OA is explained by pathology in soft tissue structures and whether US of the knee is the imaging tool of choice to visualize this pathology.
TV-Broadcasting Competition and Advertising

We analyse the rivalry between two TV-channels competing both on the market for audience and the market for advertising. We identify the nature of TV-programs emerging from this competition, and the quantity of advertising that TV-viewers will have to attend at equilibrium. Finally, we examine how a government's regulation of this quantity will affect programs' selection by the channels.
Heterogeneous Task Allocation and Sequencing via Decentralized Large Neighborhood Search

This paper focuses on decentralized task allocation and sequencing for multiple heterogeneous robots. Each task is defined as visiting a point in a subset of the robot configuration space — this de...
Prognostic Value of Baseline Neutrophil-Lymphocyte and Platelet-Lymphocyte Ratios in Local and Advanced Gastric Cancer Patients.

BACKGROUND
We aimed to investigate the prognostic value of baseline neutrophil, lymphocyte, and platelet counts along with the neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) in local and advanced gastric cancer patients.


MATERIALS AND METHODS
In this retrospective cross-sectional study, a total of 103 patients with gastric cancer were included. For all, patient characteristics and overall survival (OS) times were evaluated. Data from a complete blood count test including neutrophil, lymphocyte, monocyte, white blood cell (WBC) and platelet (Plt) count, hemoglobin level (Hb) were recorded, and the NLR and PLR were obtained for every patient prior to pathological diagnosis before any treatment was applied.


RESULTS
Of the patients, 53 had local disease, underwent surgery and were administered adjuvant chemoradiotherapy where indicated. The remaining 50 had advanced disease and only received chemotherapy. OS time was 71.6±6 months in local gastric cancer patients group and 15±2 months in the advanced gastric cancer group. Univariate analysis demonstrated that only high platelet count (p=0.013) was associated with better OS in the local gastric cancer patients. In contrast, both low NLR (p=0.029) and low PLR (p=0.012) were associated with better OS in advanced gastric cancer patients.


CONCLUSIONS
This study demonstrated that NLR and PLR had no effect on prognosis in patients with local gastric cancer who underwent surgery and received adjuvant chemoradiotherapy. In advanced gastric cancer patients, both NLR and PLR had significant effects on prognosis, so they may find application as easily measured prognostic factors for such patients.
Insights into the interpretation of light transmission aggregometry for evaluation of platelet aggregation inhibition by clopidogrel.

INTRODUCTION
When studying the efficacy of clopidogrel to inhibit platelet aggregation by light transmission aggregometry, technical decisions must be taken prior to assessment or during analysis, including, but not limited to, concentration of agonist to use and timing of the evaluation of the response on the aggregation curve obtained (peak ADP-stimulated platelet aggregation vs. late aggregation). We investigated how some of these technical modalities affected the results of platelet aggregation obtained after clopidogrel administration.


MATERIALS AND METHODS
One hundred and twenty stable coronary artery disease patients requiring a diagnostic angiography were recruited prior to pre-treatment with clopidogrel. Blood samples were tested before clopidogrel initiation and immediately preceding coronary angiography using light transmission aggregometry with either 5 or 20 microM of ADP. Aggregation was measured at maximal amplitude (peak), and 5 minutes after agonist addition (late).


RESULTS
While measurements of platelet aggregation as either peak or late aggregation were strongly correlated, peak platelet aggregation was significantly higher than late aggregation, by 10.8% and by 10.3% with ADP 5 and 20 microM, respectively. Moreover, the use of ADP 20 microM resulted in less spontaneous disaggregation than 5 microM in the absence of clopidogrel (11.8% and 4.8% with ADP 5 microM and 20 microM, respectively).


CONCLUSIONS
When assessing platelet aggregation following clopidogrel, measurement of late aggregation after addition of ADP 20 microM should be preferred. Large clinical trials should be conducted to assess which parameter between residual aggregation or inhibition of platelet aggregation by clopidogrel best predicts clinical efficacy of the drug.