LLukas22/scidocs huggingface dataset:
Electrical Stimulation to Identify Neural Elements on the Heart: Their Role in Atrial Fibrillation

Experimental Studies: Anesthetized dogs were subjected to a right then left thoracotomy. Two modes of electrical stimulation were used to activate ganglionated plexi (GP) on the epicardium of the atria: (1) Near the base of each pulmonary vein (PV), trains of high frequency stimuli (HFS) were coupled to each atrial paced beat so as to fall within the refractory period to achieve nerve stimulation without atrial excitation; and (2) Continuous HFS was applied via plaque electrodes sutured to epicardial fat pads (containing a GP) near the right superior (RS) and left superior (LS) PVs. The chest was then closed. An ablation catheter, inserted percutaneously, was positioned fluoroscopically in the right atrium across from the epicardial plaque electrode near the RSPV. Transeptal puncture was used to place an ablation catheter at the LSPV-left atrial junction. HFS applied to each of the epicardial fat pads induced atrial fibrillation (AF) and also caused high grade AV block due to a strong parasympathetic effect on the AV node. Radiofrequency ablation from the right and left atrial endocardium abolished the vagal response to HFS delivered to the plaque electrodes on the fat pads close to the RSPV and LSPV, respectively. Clinical Studies: Sixty (60) patients with paroxysmal or persistent AF underwent PV antrum isolation (27 patients) or PV antrum isolation plus left atrial GP ablation (33 patients). Endocardial HFS at the border of the PV antra near the 4 GPs produced AF and high grade AV block (vagal response) during AF. RFA at these sites abolished the vagal response. Testing in a small number of patients with very short follow-up suggests that adding GP ablation to PV antrum isolation may increase ablation success (absence of AF recurrence) from 70% to 91%. Conclusions: These basic and clinical studies suggest that localized cardiac autonomic ganglia (GPs) may play a critical role in the initiation and maintenance of AF.
Mindfulness-based cognitive therapy for generalized anxiety disorder.

UNLABELLED
While cognitive behavior therapy has been found to be effective in the treatment of generalized anxiety disorder (GAD), a significant percentage of patients struggle with residual symptoms. There is some conceptual basis for suggesting that cultivation of mindfulness may be helpful for people with GAD. Mindfulness-based cognitive therapy (MBCT) is a group treatment derived from mindfulness-based stress reduction (MBSR) developed by Jon Kabat-Zinn and colleagues. MBSR uses training in mindfulness meditation as the core of the program. MBCT incorporates cognitive strategies and has been found effective in reducing relapse in patients with major depression (Teasdale, J. D., Segal, Z. V., Williams, J. M. G., Ridgeway, V., Soulsby, J., & Lau, M. (2000). Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy. Journal of Consulting and Clinical Psychology, 6, 615-623).


METHOD
Eligible subjects recruited to a major academic medical center participated in the group MBCT course and completed measures of anxiety, worry, depressive symptoms, mood states and mindful awareness in everyday life at baseline and end of treatment.


RESULTS
Eleven subjects (six female and five male) with a mean age of 49 (range=36-72) met criteria and completed the study. There were significant reductions in anxiety and depressive symptoms from baseline to end of treatment.


CONCLUSION
MBCT may be an acceptable and potentially effective treatment for reducing anxiety and mood symptoms and increasing awareness of everyday experiences in patients with GAD. Future directions include development of a randomized clinical trial of MBCT for GAD.
Library Guides: Civil Engineering & Construction Management: Articles

This guide will assist you in locating and effectively using print and electronic resources relating to Civil Engineering and Construction Management.
An Intelligent Tutoring System for Japanese Language Particles with User Assessment and Feedback

In recent years, an increasing number of Ateneo students have been taking an interest in the Japanese language. For Ateneo students beginning their study of the language however, Japanese particles are difficult concepts because they cannot be translated to equivalent words in English. For a beginner learner, it is inevitable to view a second language with the lens of a first language as shown by the concept of transfer in second language acquisition. As a result, learners tend to misconstrue Japanese particles by attempting to understand them with respect to non-existent equivalents in English. In this research, we develop an intelligent tutoring system for Ateneo students taking introductory Japanese (FLC 1JSP) to aid them better understand Japanese particles. The system would assess the learner’s understanding of Japanese particles by practice and depending on which particle where most mistakes are made, the system would give instructional feedback. Feedback to be implemented in the system use visual prototypes that represent the meaning of the particle. We hope to see if visual representations can also teach Japanese particles to students as an alternative to text-detailed explanations such as those commonly found in textbooks.
Instructed Second Language Acquisition A Literature Review

Opinions expressed in this report are those of the authors and do not necessarily coincide with those of the Ministry of Education Research reports are also available on the Ministry's website: www.minedu.govt.nz under the Research heading. Reports from Auckland UniServices Limited should only be used for the purposes for which they were commissioned. If it is proposed to use a report prepared by Auckland UniServices Limited for a different purpose or in a different context from that intended at the time of commissioning the work, then UniServices should be consulted to verify whether the report is being correctly interpreted. In particular it is requested that, where quoted, conclusions given in UniServices reports should be stated in full.
Composite hydrogel scaffolds incorporating decellularized adipose tissue for soft tissue engineering with adipose-derived stem cells.

An injectable tissue-engineered adipose substitute that could be used to deliver adipose-derived stem cells (ASCs), filling irregular defects and stimulating natural soft tissue regeneration, would have significant value in plastic and reconstructive surgery. With this focus, the primary aim of the current study was to characterize the response of human ASCs encapsulated within three-dimensional bioscaffolds incorporating decellularized adipose tissue (DAT) as a bioactive matrix within photo-cross-linkable methacrylated glycol chitosan (MGC) or methacrylated chondroitin sulphate (MCS) delivery vehicles. Stable MGC- and MCS-based composite scaffolds were fabricated containing up to 5 wt% cryomilled DAT through initiation with long-wavelength ultraviolet light. The encapsulation strategy allows for tuning of the 3-D microenvironment and provides an effective method of cell delivery with high seeding efficiency and uniformity, which could be adapted as a minimally-invasive in situ approach. Through in vitro cell culture studies, human ASCs were assessed over 14 days in terms of viability, glycerol-3-phosphate dehydrogenase (GPDH) enzyme activity, adipogenic gene expression and intracellular lipid accumulation. In all of the composites, the DAT functioned as a cell-supportive matrix that enhanced ASC viability, retention and adipogenesis within the gels. The choice of hydrogel also influenced the cell response, with significantly higher viability and adipogenic differentiation observed in the MCS composites containing 5 wt% DAT. In vivo analysis in a subcutaneous Wistar rat model at 1, 4 and 12 weeks showed superior implant integration and adipogenesis in the MCS-based composites, with allogenic ASCs promoting cell infiltration, angiogenesis and ultimately, fat formation.
The spectrum of Merkel cell polyomavirus expression in Merkel cell carcinoma, in a variety of cutaneous neoplasms, and in neuroendocrine carcinomas from different anatomical sites.

Most Merkel cell carcinomas display pure neuroendocrine differentiation (pure Merkel cell carcinoma), whereas a minority show combined neuroendocrine and nonneuroendocrine elements (combined Merkel cell carcinoma). Recent identification of Merkel cell polyomavirus DNA and Merkel cell polyomavirus large T antigen expression in a proportion of Merkel cell carcinomas has suggested viral-induced oncogenesis. To date, Merkel cell polyomavirus immunohistochemistry has shown an absence of viral large T antigen expression in combined Merkel cell carcinoma as well as select non-Merkel cell carcinoma cutaneous lesions and visceral neuroendocrine tumors. In our series, we aimed to further characterize the frequency and pattern of Merkel cell polyomavirus large T antigen expression by CM2B4 immunohistochemistry in primary and metastatic Merkel cell carcinoma (pure Merkel cell carcinoma and combined Merkel cell carcinoma) and various non-Merkel cell carcinoma lesions from patients with Merkel cell carcinoma, patients without Merkel cell carcinoma, and individuals with altered immune function. Merkel cell polyomavirus large T antigen was detected in 17 (63%) of 27 pure Merkel cell carcinomas and absent in all 15 (0%) combined Merkel cell carcinomas. Furthermore, complete concordance (100%) of Merkel cell polyomavirus large T antigen expression was observed in 10 cases of primary Merkel cell carcinoma and subsequent tumor metastases. We also evaluated 70 non-Merkel cell carcinoma lesions including 15 cases each of pulmonary and gastrointestinal neuroendocrine tumors. All 70 non-Merkel cell carcinoma lesions were negative for Merkel cell polyomavirus by CM2B4 immunohistochemistry, irrespective of any known Merkel cell carcinoma diagnosis and immune status. In summary, our identification of Merkel cell polyomavirus large T antigen expression in a subset of Merkel cell carcinoma and lack of findings in combined Merkel cell carcinomas and non-Merkel cell carcinoma lesions concur with earlier findings and implicate Merkel cell polyomavirus-independent pathogenesis in these cases. Overall, CM2B4 immunohistochemistry appears to be a specific method for Merkel cell polyomavirus detection and has the potential to play an important role in the diagnosis and classification of Merkel cell carcinoma in the future.
Gravitational waves and fundamental physics

I give an overview of the motivations for gravitational-wave research, concentrating on the aspects related to ``fundamental'' physics.
Does democracy preempt civil wars ?

This paper proposes that the appropriate measure for capturing the political aspects that matter for social conflict is the level of inclusiveness of the political system. I analyze, theoretically and empirically, the relationship between inclusiveness of the political system and its stability. According to the model, high inclusive systems, such as the proportional representation system, are more stable than low inclusive systems that favor political exclusion, such as the majoritarian system. Empirically, it seems that democracy is not enough to deter social conflicts. The level of inclusiveness of the political system is important in explaining the probability of civil wars. D 2004 Elsevier B.V. All rights reserved. JEL classification: H11; O11
Sorafenib in combination with intensive chemotherapy in elderly patients with acute myeloid leukemia: results from a randomized, placebo-controlled trial.

PURPOSE
The prognosis of elderly patients with acute myeloid leukemia (AML) is still dismal even with intensive chemotherapy. In this trial, we compared the antileukemic activity of standard induction and consolidation therapy with or without the addition of the kinase inhibitor sorafenib in elderly patients with AML.


PATIENTS AND METHODS
All patients received standard cytarabine and daunorubicin induction (7+3 regimen) and up to two cycles of intermediate-dose cytarabine consolidation. Two hundred one patients were equally randomly assigned to receive either sorafenib or placebo between the chemotherapy cycles and subsequently for up to 1 year after the beginning of therapy. The primary objective was to test for an improvement in event-free survival (EFS). Overall survival (OS), complete remission (CR) rate, tolerability, and several predefined subgroup analyses were among the secondary objectives.


RESULTS
Age, sex, CR and early death (ED) probability, and prognostic factors were balanced between both study arms. Treatment in the sorafenib arm did not result in significant improvement in EFS or OS. This was also true for subgroup analyses, including the subgroup positive for FLT3 internal tandem duplications. Results of induction therapy were worse in the sorafenib arm, with higher treatment-related mortality and lower CR rates. More adverse effects occurred during induction therapy in the sorafenib arm, and patients in this arm received less consolidation chemotherapy as a result of higher induction toxicity.


CONCLUSION
In conclusion, combination of standard induction and consolidation therapy with sorafenib in the schedule investigated in our trial is not beneficial for elderly patients with AML.
Space-time Evolution of J/psi Production in High Energy Nuclear Collisions

The space-time evolution of J/psi production in central Au+Au collisions at RHIC energy is investigated in a transport model. Both gluon dissociation and continuous regeneration of J/psis inside deconfined state are considered.
Adaptive Estimation of the State of Charge for Lithium-Ion Batteries: Nonlinear Geometric Observer Approach

This paper considers the state of charge (SoC) and parameter estimation of lithium-ion batteries. Different from various prior arts, where estimation is based on local linearization of a nonlinear battery model, nonlinear geometric observer approach is followed to design adaptive observers for the SoC and parameter estimation based on nonlinear battery models. A major advantage of the proposed approach is the possibility to establish the exponential stability of the resultant error dynamics of state and parameter estimation. The proposed adaptive observers are shown to be robust with respect to unmodeled process uncertainties. Analysis also shows the design tradeoff between the convergence rate and the robustness of the estimation error dynamics with respect to the measurement noise. Simulation and experimental results validate the effectiveness and main advantages of the proposed approach. Error analysis is presented and explains the experimental results.
A 2-transistor/1-resistor artificial synapse capable of communication and stochastic learning in neuromorphic systems

Resistive (or memristive) switching devices based on metal oxides find applications in memory, logic and neuromorphic computing systems. Their small area, low power operation, and high functionality meet the challenges of brain-inspired computing aiming at achieving a huge density of active connections (synapses) with low operation power. This work presents a new artificial synapse scheme, consisting of a memristive switch connected to 2 transistors responsible for gating the communication and learning operations. Spike timing dependent plasticity (STDP) is achieved through appropriate shaping of the pre-synaptic and the post synaptic spikes. Experiments with integrated artificial synapses demonstrate STDP with stochastic behavior due to (i) the natural variability of set/reset processes in the nanoscale switch, and (ii) the different response of the switch to a given stimulus depending on the initial state. Experimental results are confirmed by model-based simulations of the memristive switching. Finally, system-level simulations of a 2-layer neural network and a simplified STDP model show random learning and recognition of patterns.
Sudden Hearing Loss in Patients with Chronic Hepatitis C Treated with Pegylated Interferon/Ribavirin

BACKGROUND:Sudden hearing loss has been reported on standard interferon (IFN)-α2 therapy. This is the first report on the occurrence of sudden hearing loss in six cases of chronic hepatitis C in temporal relation to treatment with pegylated (PEG)-IFN alfa2a or b/ribavirin combination therapy. Three patients were treated in an ongoing randomized placebo–controlled trial comparing the addition of 200 mg amantadine or placebo to the combination of 180 μg PEG-IFN α2a (PEGASYS®, Roche, Basel, CH)/wk and 1–1.2 g ribavirin/d (COPEGUS®, Roche, Nutley, USA) in de novo patients infected with HCV genotype 1. Sudden hearing loss and tinnitus developed on day 1 and after 4, 23, 25, 36, and 40 wk of treatment, respectively.CONCLUSIONS:Sudden hearing loss may occur in about 1% of patients on PEG-IFN/ribavirin combination therapy. This rate was not different to that observed in an untreated population. Possible mechanisms involved include direct ototoxicity of IFN, autoimmunity, and hematological changes. In contrast to published cases on auditory disability due to standard IFN, hearing loss did not fully resolve after discontinuation of therapy with PEG-IFN. On the other hand, symptoms did not worsen on continued treatment. Therefore, the decision whether to continue or to stop the treatment when signs of ototoxicity appear is based on the clinical judgment of the treating physician.
Partial directed coherence: a new concept in neural structure determination

 This paper introduces a new frequency-domain approach to describe the relationships (direction of information flow) between multivariate time series based on the decomposition of multivariate partial coherences computed from multivariate autoregressive models. We discuss its application and compare its performance to other approaches to the problem of determining neural structure relations from the simultaneous measurement of neural electrophysiological signals. The new concept is shown to reflect a frequency-domain representation of the concept of Granger causality.
Visualization of vapor formation regimes during capillary-fed boiling in sintered-powder heat pipe wicks

The current study investigates capillary-fed boiling of water from porous sintered powder wicks used in emerging high-effective-conductivity vapor chamber heat spreaders intended for management of hot spots with heat fluxes exceeding 500 W cm . Characterization of 1 mm thick wicks composed of 100 lm sintered copper particles is performed in a test facility which replicates the capillary feeding conditions that occur in such devices. Boiling curves are obtained for a 5 mm 5 mmheated input area, along with high-speed in-situ visualization of the evaporation/boiling processes. Understanding the vapor formation regimes is essential to predictive modeling of the observed characteristics. Schematic representations of such regimes along the boiling curves are presented for homogeneous and modified wick structures. In general, incipience of boiling in sintered-powder wicks reduces the effective thermal resistance and, for small heat input areas, does not cause liquid starvation due to a capillary limitation. The thermal performance enhancement provided by two different augmentation methods is quantified and explained in terms of the observed vapor formation characteristics. Patterns fabricated within the sintered powder create multi-scale wicks with regions of different pore size. These patterns reduce thermal resistance throughout the boiling regime by increasing the permeability to vapor exiting thewick, as confirmed by visualization of the preferential vapor venting from the surface. At the highest heat fluxes investigated prior to dryout, a thin liquid film is observed to form in the recessed patterned areas at the base of thewick. Integration of copper-coated carbon nanotubes on to the sintered powder reduces the required superheat for boiling incipience, thus reducing the overall thermal resistance at low heat fluxes. Evaporation and boiling regime heat transfer predictions from several available correlations are compared to the current results, and are shown to corroborate the conclusions regarding vapor permeability. 2012 Elsevier Ltd. All rights reserved.
Present but sick : a three-wave study on job demands , presenteeism and burnout

Purpose – The opposite of absenteeism, presenteeism, is the phenomenon of employees staying at work when they should be off sick. Presenteeism is an important problem for organizations, because employees who turn up for work, when sick, cause a reduction in productivity levels. The central aim of the present study is to examine the longitudinal relationships between job demands, burnout (exhaustion and depersonalization), and presenteeism. We hypothesized that job demands and exhaustion (but not depersonalization) would lead to presenteeism, and that presenteeism would lead to both exhaustion and depersonalization over time. Design/methodology/approach – The hypotheses were tested in a sample of 258 staff nurses who filled out questionnaires at three measurement points with 1.5 years in-between the waves. Findings – Results were generally in line with predictions. Job demands caused more presenteeism, while depersonalization was an outcome of presenteeism over time. Exhaustion and presenteeism were found to be reciprocal, suggesting that when employees experience exhaustion, they mobilize compensation strategies, which ultimately increases their exhaustion. Research limitations/implications – These findings suggest that presenteeism can be seen as a risk-taking organizational behavior and shows substantial longitudinal relationships with job demands and burnout. Practical implications – The study suggests that presenteeism should be prevented at the
A brief behavioural treatment of chronic post-traumatic stress disorder in earthquake survivors: results from an open clinical trial.

BACKGROUND
Natural disasters such as earthquakes affect large numbers of people. Given the extent of the mental health problem following earthquakes, brief, effective and cost-effective treatment interventions are urgently needed. The present study examined whether cognitive-behavioural treatment could be shortened to a minimum number of sessions without undermining its effectiveness in post-traumatic stress disorder (PTSD).


METHOD
The study participants (N=231) were consecutive referrals to five project sites in the earthquake region in Turkey a mean of 13 months after the disaster. A modified behavioural treatment (BT) was used, which involved self-exposure instructions based on an enhancement of 'sense of control' rather than a habituation rationale and minimal cognitive interventions. The duration of treatment was variable, involving as many sessions as required for clinical improvement. Survival analysis was used to explore the minimum number of sessions required for clinical improvement, and multiple regression analysis to examine the predictors of outcome.


RESULTS
The survivors received a mean of 4-3 sessions. Significant treatment effects and clinically meaningful effect sizes were noted on all measures. The treatment improved all PTSD and depression symptoms. The cumulative proportion of improved cases was 76% after one session and 88% after two sessions. No baseline variable predicted treatment outcome.


CONCLUSIONS
The modified BT appears to be promising as an effective one- or two-session intervention for earthquake survivors. It may be particularly useful in large-scale disasters as a cost-effective treatment that can be relatively easily disseminated to mass populations. Further research is needed to clarify the possible role of a treatment focus on sense of control in rapid recovery from traumatic stress.
Gaze- vs. hand-based pointing in virtual environments

This paper contributes to the nascent body of literature on pointing performance in Virtual Environments (VEs), comparing gaze- and hand-based pointing. Contrary to previous findings, preliminary results indicate that gaze-based pointing is slower than hand-based pointing for distant objects.