LLukas22/scidocs huggingface dataset:
Real-time lane markings recognition based on seed-fill algorithm

Road markings express the rules for the road while catching the upcoming road layout. These rules are applied to driving scenarios by real drivers who are known to Highway driving manuals. However, autonomous driving vehicles must read the roads in the same way that real drivers do. In this paper, the problem of automatically reading the road markings is addressed. A new approach for lane classification using the onboard camera is presented. As an initial step, the road boundaries are detected using the Hough transform model. The region of interest (ROI) is divided into two sub-regions. Hough Transform is applied to each of the sub-regions independently. The computational time required for lane detection is improved in this way. After that, adaptive smoothing and some processing steps are added to reduce the noise while still making the close edge's apart. Then, Seed fill algorithm is applied to the lanes location to identify the lane markings types. This method is able to recognize five types of lane markings such as: dashed, solid, double solid, dashed-solid and solid-dashed. The method is applied to a large set of video sequences with various situations and showed that the accuracy is over 95%.
Studies on Al 6061-SiC and Al 7075-Al 2 O 3 Metal Matrix Composites

The aluminum based composites are increasingly being used in the transport, aerospace, marine, automobile and mineral processing industries, owing to their improved strength, stiffness and wear resistance properties. The widely used reinforcing materials for these composites are silicon carbide, aluminum oxide and graphite in the form of particles or whiskers. The ceramic particles reinforced aluminum composites are termed as new generation material and these can be tailored and engineered with specific required properties for specific application requirements. Particle reinforced composites have a better plastic forming capability than that of the whisker or fiber reinforced ones, and thus they have emerged as most sought after material with cost advantage and they are also known for excellent heat and wear resistance applications. In this paper it is aimed to present the experimental results of the studies conducted regarding hardness, tensile strength and wear resistance properties of Al6061-SiC and Al7075-Al2O3 composites. The composites are prepared using the liquid metallurgy technique, in which 2-6 wt. %’age of particulates were dispersed in the base matrix in steps of 2. The obtained cast composites of Al6061-SiC and Al7075-Al2O3 and the castings of the base alloys were carefully machined to prepare the test specimens for density, hardness, mechanical, tribological tests and as well as for microstructural studies as per ASTM standards. The SiC and Al2O3 resulted in improving the hardness and density of their respective composites. Further, the increased %’age of these reinforcements contributed in increased hardness and density of the composites. The microphotographs of the composites studied revealed the uniform distribution of 44 G. B. Veeresh Kumar, C. S. P. Rao, N. Selvaraj, M. S. Bhagyashekar Vol.9, No.1 the particles in the matrix system. The experimental density values were agreed with that of the theoretical density values of the composites obtained using the rule of mixture for composites. The dispersed SiC in Al6061 alloy and Al2O3 in Al7075 alloy contributed in enhancing the tensile strength of the composites. The wear factor K obtained using computerized pin on disc wear tester with counter surface as EN31 steel disc (HRC60) and the composite pin as specimens, demonstrated the superior wear resistance property of the composites.
Diosmin Protects against Ethanol-Induced Gastric Injury in Rats: Novel Anti-Ulcer Actions

Alcohol consumption has been commonly associated with gastric mucosal lesions including gastric ulcer. Diosmin (DIO) is a natural citrus flavone with remarkable antioxidant and anti-inflammatory features that underlay its protection against cardiac, hepatic and renal injuries. However, its impact on gastric ulcer has not yet been elucidated. Thus, the current study aimed to investigate the potential protective effects of DIO against ethanol-induced gastric injury in rats. Pretreatment with DIO (100 mg/kg p.o.) attenuated the severity of ethanol gastric mucosal damage as evidenced by lowering of ulcer index (UI) scores, area of gastric lesions, histopathologic aberrations and leukocyte invasion. These actions were analogous to those exerted by the reference antiulcer sucralfate. DIO suppressed gastric inflammation by curbing of myeloperoxidase (MPO) and tumor necrosis factor-α (TNF-α) levels along with nuclear factor kappa B (NF-κB) p65 expression. It also augmented the anti-inflammatory interleukin-10 (IL-10) levels. Meanwhile, DIO halted gastric oxidative stress via inhibition of lipid peroxides with concomitant enhancement of glutathione (GSH), glutathione peroxidase (GPx) and the total antioxidant capacity (TAC). With respect to gastric mucosal apoptosis, DIO suppressed caspase-3 activity and cytochrome C (Cyt C) with enhancement of the anti-apoptotic B cell lymphoma-2 (Bcl-2) in favor of cell survival. These favorable actions were associated with upregulation of the gastric cytoprotective prostaglandin E2 (PGE2) and nitric oxide (NO). Together, these findings accentuate the gastroprotective actions of DIO in ethanol gastric injury which were mediated via concerted multi-pronged actions, including suppression of gastric inflammation, oxidative stress and apoptosis besides boosting of the antioxidant and the cytoprotective defenses.
The Role of Margin Status and Reexcision in Local Recurrence Following Breast Conservation Surgery

Breast conservation surgery (BCS) results in survival equal to mastectomy for early-stage breast cancer. Ipsilateral breast tumor recurrence (IBTR) after BCS is thought to be related to margin status. At our institution, reexcision is performed only if tumor is at inked margin or with extensive disease close to multiple margins. The purpose of this study was to determine rates of reexcision and recurrences among BCS patients using this policy. We performed an institutional review board-approved retrospective analysis of BCS patients who underwent surgery between January 2001 and June 2005. We identified patients who had a second breast excision within 8 weeks of the first, and those patients with an IBTR. Clinical and pathologic features of patients’ tumors were reviewed. We identified 543 patients who underwent BCS, 84 patients (15.5 %) underwent reexcision for margin status. The crude IBTR rate was 3.4 %, and the 5-year local recurrence-free survival of the reexcised group was 90.6 % compared with 97.4 % in the non-reexcised group (p = 0.0097). Of the 64 reexcision patients, 6 (9.4 %) had an IBTR versus 12 (2.6 %) of the 459 non-reexcised patients (p = 0.0151). Our reexcision rate is low compared with other reports. This results from a policy that defines “no tumor on ink” as an adequate margin for BCS, and the use of selective irradiation boosts based on margins assessed by our pathologists. Our local recurrence rate compares favorably with those seen in other studies while minimizing the need for additional operations. A higher IBTR rate after reexcision likely reflects tumor biology.
Automated Theorem Proving in GeoGebra: Current Achievements

GeoGebra is an open-source educational mathematics software tool, with millions of users worldwide. It has a number of features (integration of computer algebra, dynamic geometry, spreadsheet, etc.), primarily focused on facilitating student experiments, and not on formal reasoning. Since including automated deduction tools in GeoGebra could bring a whole new range of teaching and learning scenarios, and since automated theorem proving and discovery in geometry has reached a rather mature stage, we embarked on a project of incorporating and testing a number of different automated provers for geometry in GeoGebra. In this paper, we present the current achievements and status of this project, and discuss various relevant challenges that this project raises in the educational, mathematical and software contexts. We will describe, first, the recent and forthcoming changes demanded by our project, regarding the implementation and the user interface of GeoGebra. Then we present our vision of the educational scenarios that could be supported by automated reasoning features, and how teachers and students could benefit from the present work. In fact, current performance of GeoGebra, extended with automated deduction tools, is already very promising—many complex theorems can be proved in less than 1 second. Thus, we believe that many new and exciting ways of using GeoGebra in the classroom are on their way.
Conditions potentially sensitive to a Personal Health Record (PHR) intervention, a systematic review

BACKGROUND
Personal Health Records (PHRs) are electronic health records controlled, shared or maintained by patients to support patient centered care. The potential for PHRs to transform health care is significant; however, PHRs do not always achieve their potential. One reason for this may be that not all health conditions are sensitive to the PHR as an intervention. The goal of this review was to discover which conditions were potentially sensitive to the PHR as an intervention, that is, what conditions have empirical evidence of benefit from PHR-enabled management.


METHODS
A systematic review of Medline and CINAHL was completed to find articles assessing PHR use and benefit from 2008 to 2014 in specific health conditions. Two researchers independently screened and coded articles. Health conditions with evidence of benefit from PHR use were identified from the included studies.


RESULTS
23 papers were included. Seven papers were RCTs. Ten health conditions were identified, seven of which had documented benefit associated with PHR use: asthma, diabetes, fertility, glaucoma, HIV, hyperlipidemia, and hypertension. Reported benefits were seen in terms of care quality, access, and productivity, although many benefits were measured by self-report through quasi-experimental studies. No study examined morbidity/mortality. No study reported harm from the PHR.


CONCLUSION
There is a small body of condition specific evidence that has been published. Conditions with evidence of benefit when using PHRs tended to be chronic conditions with a feedback loop between monitoring in the PHR and direct behaviours that could be self-managed. These findings can point to other potentially PHR sensitive health conditions and guide PHR designers, implementers, and researchers. More research is needed to link PHR design, features, adoption and health outcomes to better understand how and if PHRs are making a difference to health outcomes.
Impact of Stepping Stones on incidence of HIV and HSV-2 and sexual behaviour in rural South Africa: cluster randomised controlled trial

OBJECTIVE
To assess the impact of Stepping Stones, a HIV prevention programme, on incidence of HIV and herpes simplex type 2 (HSV-2) and sexual behaviour.


DESIGN
Cluster randomised controlled trial.


SETTING
70 villages (clusters) in the Eastern Cape province of South Africa.


PARTICIPANTS
1360 men and 1416 women aged 15-26 years, who were mostly attending schools.


INTERVENTION
Stepping Stones, a 50 hour programme, aims to improve sexual health by using participatory learning approaches to build knowledge, risk awareness, and communication skills and to stimulate critical reflection. Villages were randomised to receive either this or a three hour intervention on HIV and safer sex. Interviewers administered questionnaires at baseline and 12 and 24 months and blood was tested for HIV and HSV-2.


MAIN OUTCOME MEASURES



PRIMARY OUTCOME MEASURE
incidence of HIV. Other outcomes: incidence of HSV-2, unwanted pregnancy, reported sexual practices, depression, and substance misuse.


RESULTS
There was no evidence that Stepping Stones lowered the incidence of HIV (adjusted incidence rate ratio 0.95, 95% confidence interval 0.67 to 1.35). The programme was associated with a reduction of about 33% in the incidence of HSV-2 (0.67, 0.46 to 0.97; P=0.036)-that is, Stepping Stones reduced the number of new HSV-2 infections over a two year period by 34.9 (1.6 to 68.2) per 1000 people exposed. Stepping Stones significantly improved a number of reported risk behaviours in men, with a lower proportion of men reporting perpetration of intimate partner violence across two years of follow-up and less transactional sex and problem drinking at 12 months. In women desired behaviour changes were not reported and those in the Stepping Stones programme reported more transactional sex at 12 months.


CONCLUSION
Stepping Stones did not reduce incidence of HIV but had an impact on several risk factors for HIV-notably, HSV-2 and perpetration of intimate partner violence.


TRIAL REGISTRATION
Clinical Trials NCT00332878.
Cortical Firing and Sleep Homeostasis

The need to sleep grows with the duration of wakefulness and dissipates with time spent asleep, a process called sleep homeostasis. What are the consequences of staying awake on brain cells, and why is sleep needed? Surprisingly, we do not know whether the firing of cortical neurons is affected by how long an animal has been awake or asleep. Here, we found that after sustained wakefulness cortical neurons fire at higher frequencies in all behavioral states. During early NREM sleep after sustained wakefulness, periods of population activity (ON) are short, frequent, and associated with synchronous firing, while periods of neuronal silence are long and frequent. After sustained sleep, firing rates and synchrony decrease, while the duration of ON periods increases. Changes in firing patterns in NREM sleep correlate with changes in slow-wave activity, a marker of sleep homeostasis. Thus, the systematic increase of firing during wakefulness is counterbalanced by staying asleep.
Contextual Injection of Quality Measures into Software Engineering Processes

Despite improvements in software engineering processes and tools, concrete preventative and analytical software quality assurance activities are still typically manually triggered and determined, resulting in missed or untimely quality opportunities and increased project overhead. Quality goals, when defined, lack holistic environmental support for automated performance measurement and governance that is tightly integrated in the low-level operational software engineering processes. This results in higher quality risks and cost risks. Based on adaptive process management, an approach is presented that injects situationally-determined quality measure proposals into the concrete workflows of software engineers, using contextual semantic knowledge and multi-agent quality goal tracking and decision-making. Our evaluation shows the feasibility of the approach for automatically providing timely quality measure guidance to software engineers without disrupting their current activities. This supports process governance while reducing quality risks and costs during software development
Distributed Reinforcement Learning via Gossip

We consider the classical TD(0) algorithm implemented on a network of agents wherein the agents also incorporate updates received from neighboring agents using a gossip-like mechanism. The combined scheme is shown to converge for both discounted and average cost problems.
On topological groups with a first-countable remainder , II

Article history: Received 22 December 2013 Received in revised form 15 July 2014 Available online 26 September 2015 Dedicated to the Memory of Mary Ellen Rudin, a Great Person and a Great Mathematician MSC: 54H11 54A25 54B05
Ketamine as a neuroprotective and anti-inflammatory agent in children undergoing surgery on cardiopulmonary bypass: a pilot randomized, double-blind, placebo-controlled trial.

OBJECTIVE
Infants are potentially more susceptible to cell death mediated via glutamate excitotoxicity attributed to cardiopulmonary bypass. We hypothesized that ketamine, via N-methyl D-aspartate receptor blockade and anti-inflammatory effects, would reduce central nervous system injury during cardiopulmonary bypass.


METHODS
We randomized 24 infants, without chromosomal abnormalities, to receive ketamine (2 mg/kg, n = 13) or placebo (saline, n = 11) before cardiopulmonary bypass for repair of ventricular septal defects. Plasma markers of inflammation and central nervous system injury were compared at the end of surgery, and 6, 24, and 48 hrs after surgery. Magnetic resonance imaging and spectroscopy before cardiopulmonary bypass and at the time of hospital discharge were performed in a subset of cases and controls (n = 5 in each group). Cerebral hemodynamics were monitored postoperatively using near-infrared spectroscopy, and neurodevelopmental outcomes were assessed using Bayley Scales of Infant Development-II before and 2-3 wks after surgery.


RESULTS
Statistically significant differences were noted in preoperative inspired oxygen levels, intraoperative cooling and postoperative temperature, respiratory rate, platelet count, and bicarbonate levels. The peak concentration of C-reactive protein was lower in cases compared to controls at 24 hrs (p = .048) and 48 hrs (p = .001). No significant differences were noted in the expression of various cytokines, chemokines, S100, and neuron-specific enolase between the cases and controls. Magnetic resonance imaging with spectroscopy studies showed that ketamine administration led to a significant decrease in choline and glutamate plus glutamine/creatine in frontal white matter. No statistically significant differences occurred between pre- and postoperative Bayley Scales of Infant Development-II scores.


CONCLUSIONS
We did not find any evidence for neuroprotection or neurotoxicity in our pilot study. A large, adequately powered randomized control trial is needed to discern the central nervous system effect of ketamine on the developing brain. brain.


TRIAL REGISTRATION
The trial is registered at www.ClinicalTrials.gov, NCT00556361.
Aerobic interval training improves oxygen uptake efficiency by enhancing cerebral and muscular hemodynamics in patients with heart failure.

BACKGROUND
Abnormal ventilatory/hemodynamic responses to exercise contribute to functional impairment in patients with heart failure (HF). This study investigates how interval and continuous exercise regimens influence functional capacity by modulating ventilatory efficiency and hemodynamic function in HF patients.


METHODS
Forty-five HF patients were randomized to perform either aerobic interval training (AIT; 3-minute intervals at 40% and 80% VO(2peak)) or moderate continuous training (MCT; sustained 60% VO()for 30 min/day, 3 days/week for 12 weeks, or to a control group that received general healthcare (GHC). A noninvasive bio-reactance device was adopted to measure cardiac hemodynamics, whereas a near-infrared spectroscopy was employed to assess perfusion/O2 extraction in frontal cerebral lobe (∆[THb]FC/∆[HHb]FC) and vastus lateralis (∆[THb]VL/∆[HHb]VL), respectively.


RESULTS
Following the 12-week intervention, the AIT group exhibited higher oxygen uptake efficiency slope (OUES) and lower VE-VCO2 slope than the MCT and GHC groups. Furthermore, AIT, but not MCT, boosted cardiac output (CO) and increased ∆[THb]FC, ∆[THb]VL, and ∆[HHb]VL during exercise. In multivariate analyses, CO was the dominant predictor of VO(2peak). ∆[THb]FC and ∆[THb]VL, which modulated the correlation between CO and OUES, were significantly correlated with OUES. Simultaneously, ∆[THb]VL was the only factor significantly associated with VE-VCO2 slope. Additionally, AIT reduced plasma brain natriuretic peptide, myeloperoxidase, and interleukin-6 levels and increased the Short Form-36 physical/mental component scores and decreased the Minnesota Living with Heart Failure questionnaire score.


CONCLUSIONS
AIT effectively improves oxygen uptake efficiency by enhancing cerebral/muscular hemodynamics and suppresses oxidative stress/inflammation associated with cardiac dysfunction, and also promotes generic/disease-specific qualities of life in patients with HF.
Stapled transanal rectal resection to treat obstructed defecation caused by rectal intussusception and rectocele

Obstructed defecation syndrome (ODS) represents a widespread clinical problem. The patients, who are most commonly female and are often middle-aged, can spend several hours a day on the toilet [1]. Although in the last decade our understanding of defecation function and dysfunction has improved significantly, the determination of the underlying pathophysiology of ODS is still a challenge today for medical science. New evidence, showing that defecation is an integrated process involving the colon, rectum, anal sphincters, and pelvic floor muscles, suggests the complexity of the pathophysiology of ODS [2]. Thus, different mechanisms, either functional or anatomical, could lead to ODS. The aim of most of the present surgical procedures is at the treatment of the most frequent anatomical alteration: the rectocele (RE). Although various surgical techniques have been described, results are variable with different patterns of complications. Recently, a new surgical technique, stapled transanal rectal resection (STARR), has been reported as a low-morbidity and effective treatment of RE and/or rectal-intussusception (RI) causing ODS [3, 4]. This study was designed to determine the safety and efficacy of a modified STARR in patients with ODS caused by RI and/or RE.
Pretreatment plasma renin activity levels correlate with the blood pressure response to telmisartan in essential hypertension.

BACKGROUND
Although the therapeutic response to angiotensin II receptor blockers (ARBs) is assumed impaired in patients with low-renin hypertension, data are scarce about the association between levels of plasma renin activity (PRA) before treatment and response of ambulatory blood pressure (ABP) to ARBs in essential hypertension.


METHODS
We prospectively studied 11 untreated Japanese patients with essential hypertension (3 women and 8 men, mean age: 50 +/- 9 (mean +/- SD) years). After a 4-week drug-free period, telmisartan 20-40 mg was administered orally once daily for 8 weeks. PRA levels were measured before treatment. The first ABP measurement was performed at the end of the drug-free period and the second measurement at the end of the treatment period with telmisartan.


RESULTS
Telmisartan significantly decreased the 24-h ABP by 12 +/- 11 mm Hg systolic (P < 0.01) and 9 +/- 8 mm Hg diastolic (P < 0.01). Reductions in the 24-h systolic and diastolic ABPs were significantly greater in five patients with higher renin levels (> or =0.65 ng/ml/h) than in six patients with lower renin levels (<0.65 ng/ml/h) by 18 mm Hg systolic (P < 0.001) and 11 mm Hg diastolic (P < 0.05). Changes in the 24-h systolic and diastolic ABPs significantly correlated with log PRA before treatment.


CONCLUSIONS
The ABP lowering effects of telmisartan were dependent on PRA levels before treatment in patients with essential hypertension. Measurement of PRA levels before treatment is thought to be useful for prediction of the ABP lowering effects of telmisartan.