LLukas22/scidocs huggingface dataset:
L1 burst fracture with associated vertebral angioma.

Vertebral angioma is a common bone tumor. We report a case of L1 vertebral angioma revealed by type A3.2 traumatic pathological fracture of the same vertebra. Management comprised emergency percutaneous osteosynthesis and, after stabilization of the multiple trauma, arterial embolization and percutaneous kyphoplasty.
Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung Cancer.

BACKGROUND
Patients with advanced squamous-cell non-small-cell lung cancer (NSCLC) who have disease progression during or after first-line chemotherapy have limited treatment options. This randomized, open-label, international, phase 3 study evaluated the efficacy and safety of nivolumab, a fully human IgG4 programmed death 1 (PD-1) immune-checkpoint-inhibitor antibody, as compared with docetaxel in this patient population.


METHODS
We randomly assigned 272 patients to receive nivolumab, at a dose of 3 mg per kilogram of body weight every 2 weeks, or docetaxel, at a dose of 75 mg per square meter of body-surface area every 3 weeks. The primary end point was overall survival.


RESULTS
The median overall survival was 9.2 months (95% confidence interval [CI], 7.3 to 13.3) with nivolumab versus 6.0 months (95% CI, 5.1 to 7.3) with docetaxel. The risk of death was 41% lower with nivolumab than with docetaxel (hazard ratio, 0.59; 95% CI, 0.44 to 0.79; P<0.001). At 1 year, the overall survival rate was 42% (95% CI, 34 to 50) with nivolumab versus 24% (95% CI, 17 to 31) with docetaxel. The response rate was 20% with nivolumab versus 9% with docetaxel (P=0.008). The median progression-free survival was 3.5 months with nivolumab versus 2.8 months with docetaxel (hazard ratio for death or disease progression, 0.62; 95% CI, 0.47 to 0.81; P<0.001). The expression of the PD-1 ligand (PD-L1) was neither prognostic nor predictive of benefit. Treatment-related adverse events of grade 3 or 4 were reported in 7% of the patients in the nivolumab group as compared with 55% of those in the docetaxel group.


CONCLUSIONS
Among patients with advanced, previously treated squamous-cell NSCLC, overall survival, response rate, and progression-free survival were significantly better with nivolumab than with docetaxel, regardless of PD-L1 expression level. (Funded by Bristol-Myers Squibb; CheckMate 017 ClinicalTrials.gov number, NCT01642004.).
A Compromised-Time-Cost Scheduling Algorithm in SwinDeW-C for Instance-Intensive Cost-Constrained Workflows on a Cloud Computing Platform

The concept of cloud computing continues to spread widely, as it has been accepted recently. Cloud computing has many unique advantages which can be utilized to facilitate workflow execution. Instance-intensive cost-constrained cloud workflows are workflows with a large number of workflow instances (i.e. instance intensive) bounded by a certain budget for execution (i.e. cost constrained) on a cloud computing platform (i.e. cloud workflows). However, there are, so far, no dedicated scheduling algorithms for instance-intensive cost-constrained cloud workflows. This paper presents a novel compromised-time-cost scheduling algorithm which considers the characteristics of cloud computing to accommodate instance-intensive cost-constrained workflows by compromising execution time and cost with user input enabled on the fly. The simulation performed demonstrates that the algorithm can cut down the mean execution cost by over 15% whilst meeting the user-designated deadline or shorten the mean execution time by over 20% within the user-designated execution cost.
Where the action is: monitoring local trends in sexual behaviour.

OBJECTIVES
To assess the role in an overall monitoring strategy of the PLACE method of estimating local trends in sexual behaviour among individuals at social venues in areas at increased risk of HIV transmission.


METHODS
Public venues identified by community informants as places where people meet new sexual partners were visited and characterised in Karaganda, Kazakhstan, in 2002 and 2003, and in a township in South Africa in 2000 and 2003. At a subset of venues, a representative sample of individuals socialising at the venue were interviewed about their sexual behaviour. The age distribution and partnerships rates of those socialising at these venues were compared by year and with national data from Kazakhstan and South Africa obtained via household surveys.


RESULTS
Women and men socialising at venues were younger and had higher rates of new and concurrent partnerships than men and women interviewed in national household surveys. There was little apparent change in sexual behaviour between 2002 and 2003 in Karaganda. In the South African township, there was a reduction in sexual partnerships and an increase in condom use, possibly due to a local AIDS prevention programme.


CONCLUSION
Findings from the PLACE method supplement national data on sexual behaviours with data from key populations in high transmission areas, inform local targeting of interventions, and, when subsequent rounds of PLACE are implemented, can evaluate change in target populations.
One Generalization of Counters

In this paper we generalize the definition of a counter and investigate the resulting increase in power of deterministic counter automata in terms of language recognition.
Accurate Prediction of Ferrite Core Loss with Nonsinusoidal Waveforms Using Only Steinmetz Parameters

An improved calculation of ferrite core loss for nonsinusoidal waveforms separates a flux trajectory into major and minor loops via a new recursive algorithm. It is highly accurate and outperforms two previous methods for our measured data. The only characteristics of the material required are the standard Steinmetz-equation parameters.
Calcium channel blockers and mortality in elderly patients with myocardial infarction.

BACKGROUND
Although calcium channel blockers are a useful therapy in relieving angina, lowering blood pressure, and slowing conduction of atrial fibrillation, growing evidence has cast doubt on their safety in patients with coronary disease.


OBJECTIVE
To examine the association between calcium channel blocker therapy at hospital discharge and mortality in a population-based sample of elderly patients hospitalized with acute myocardial infarction.


DESIGN
Retrospective cohort study using data from medical charts and administrative files.


SETTING
All acute care hospitals in 46 states.


PATIENTS
All Medicare patients with a principal diagnosis of acute myocardial infarction consecutively discharged from the hospital alive during 8-month periods between 1994 and 1995 (N = 141,041).


MAIN OUTCOME MEASURE
Mortality at 30 days and 1 year.


RESULTS
Calcium channel blockers were widely prescribed at hospital discharge to elderly patients with myocardial infarction between 1994 and 1995 (n = 51,921), the most commonly prescribed being diltiazem (n = 21,175), nifedipine (n = 12,670), amlodipine (n = 11,683), and verapamil (n = 3639). After adjusting for illness severity and concomitant medication use, patients who were prescribed calcium channel blockers at hospital discharge did not have increased risk for 30-day or 1-year mortality, with the exception of the few (n = 116) treated with bepridil. Bepridil differs from other calcium channel blockers because of its tendency to prolong repolarization, and its association with proarrhythmic effects in elderly patients.


CONCLUSION
We did not identify a mortality risk in a large consecutive sample of elderly patients with myocardial infarction, which supports the need for additional prospective trials examining calcium channel blocker therapy for ischemic heart disease.
The chronic kidney disease outcomes and practice patterns study Brazil (CKDopps-Brazil): design, data and methodology.

INTRODUCTION
The chronic kidney disease outcomes and practice patterns study (CKDopps) is an international observational, prospective, cohort study involving patients with chronic kidney disease (CKD) stages 3-5 [estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73 m2, with a major focus upon care during the advanced CKD period (eGFR < 30 ml/min/1.73 m2)]. During a 1-year enrollment period, each one of the 22 selected clinics will enroll up to 60 advanced CKD patients (eGFR < 30 ml/min/1.73 m2 and not dialysis-dependent) and 20 earlier stage CKD patients (eGFR between 30-59 ml/min/1.73 m2).


EXCLUSION CRITERIA
age < 18 years old, patients on chronic dialysis or prior kidney transplant. The study timeline include up to one year for enrollment of patients at each clinic starting in the end of 2013, followed by up to 2-3 years of patient follow-up with collection of detailed longitudinal patient-level data, annual clinic practice-level surveys, and patient surveys. Analyses will apply regression models to evaluate the contribution of patient-level and clinic practice-level factors to study outcomes, and utilize instrumental variable-type techniques when appropriate.


CONCLUSION
Launching in 2013, CKDopps Brazil will study advanced CKD care in a random selection of nephrology clinics across Brazil to gain understanding of variation in care across the country, and as part of a multinational study to identify optimal treatment practices to slow kidney disease progression and improve outcomes during the transition period to end-stage kidney disease.
Gene Sequence Based Clustering Assists in Dereplication of Pseudoalteromonas luteoviolacea Strains with Identical Inhibitory Activity and Antibiotic Production 

Some microbial species are chemically homogenous, and the same secondary metabolites are found in all strains. In contrast, we previously found that five strains of P. luteoviolacea were closely related by 16S rRNA gene sequence but produced two different antibiotic profiles. The purpose of the present study was to determine whether such bioactivity differences could be linked to genotypes allowing methods from phylogenetic analysis to aid in selection of strains for biodiscovery. Thirteen P. luteoviolacea strains divided into three chemotypes based on production of known antibiotics and four antibacterial profiles based on inhibition assays against Vibrio anguillarum and Staphylococcus aureus. To determine whether chemotype and inhibition profile are reflected by phylogenetic clustering we sequenced 16S rRNA, gyrB and recA genes. Clustering based on 16S rRNA gene sequences alone showed little correlation to chemotypes and inhibition profiles, while clustering based on concatenated 16S rRNA, gyrB, and recA gene sequences resulted in three clusters, two of which uniformly consisted of strains of identical chemotype and inhibition profile. A major time sink in natural products discovery is the effort spent rediscovering known compounds, and this study indicates that phylogeny clustering of bioactive species has the potential to be a useful dereplication tool in biodiscovery efforts.
Bortezomib-containing regimens are effective in multiple myeloma--results of a non-interventional phase IV study.

BACKGROUND/AIMS
The incorporation of bortezomib into the chemotherapeutic regimens for non-transplant patients with multiple myeloma resulted in improved outcomes in controlled studies. This prospective, non-interventional study assessed the effectiveness and safety of bortezomib-containing regimens in daily practice.


METHODS
Patients with untreated or relapsed multiple myeloma not eligible for high-dose chemotherapy followed by autologous stem cell transplantation and who were scheduled for bortezomib mono- or combination therapy or melphalan-prednisone (MP) alone were included in this study. Dosage and treatment decisions were at the discretion of the physicians.


RESULTS
353 patients received bortezomib-containing therapies and 37 patients MP alone. Overall response rates at treatment end were 65.9% for bortezomib-containing therapies and 50.0% for MP. Partial or complete remissions considered best responses were achieved in 82.6% (first line) and 63.8% (second or later line) of the bortezomib-treated patients. The median duration of response to bortezomib-containing therapies was 18.2 months in 109 first-line and 11.3 months in 110 second- or later-line patients. Adverse drug reactions of any grade were reported during the treatment phase in 79.6% (bortezomib) and 70.3% (MP) of treated patients.


CONCLUSION
Bortezomib-containing therapies were effective in patients with multiple myeloma in a real-life setting. The increasingly individualized treatment regimens of multiple myeloma require standardized assessments of response in daily practice.
A new feather mite species of the genus Picalgoides Černý, 1974 (Astigmata: Psoroptoididae) from a passerine host in Costa Rica

A new feather mite species, Picalgoides giganteus n. sp. (Psoroptoididae: Pandalurinae), is described from the tawny-throated leaftosser Sclerurus mexicanus Sclater (Passeriformes: Furnariidae) in Costa Rica. Among the 10 species of Picalgoides Černý, 1974, including the new one, this is the third recorded from a passerine host; the remaining seven nominal species are associated with hosts of the order Piciformes. Brief data on the host-parasite associations of Picalgoides spp. are provided. Megninia megalixus Trouessart, 1885 from the short-tailed green magpie Cissa thalassina (Temminck) is transferred to Picalgoides as P. megalixus (Trouessart, 1885) n. comb.
Management System For Telecommunications Engineer Training

This paper introduces an example of engineer training conducted in a factory where telecommunication systems and related products are developed and manufactured. About 1,400 engineers are being trained There are seven specialty categories according to the types of duties of the engineers. Guidelines are prepared for these engineering specialty categories to promote well-planned training of engineers. The guidelines are posted on the factory’s intranet to invite trainees and to accept their applications.
THE EFA PROJECT: INDOOR AIR QUALITY IN EUROPEAN SCHOOLS

The objectives of the EFA project ‘Indoor Air Pollution in Schools’ were to collect information on indoor air quality (IAQ) in European schools, to review the related policies and preventive programs and to formulate recommendations aimed at providing a healthy school environment. IAQ in schools should be recognized as a priority topic for public health. School buildings are used by a large number of people for a long time but its IAQ has been much less studied than in other buildings. Schools frequently have serious indoor problems because of poor building construction, maintenance, cleaning and ventilation; high levels of VOCs and allergens are reported. The IAQ in schools can cause various shortand long-term negative health effects and discomfort, particularly in subjects with allergy. Nowadays only a very few European countries have guidelines aimed at improving IAQ. A multidisciplinary European program aimed at improving the IAQ in schools is needed. INDEX TERMS Schools, air pollutants, allergies and asthma, policy. INTRODUCTION The European Federation of Asthma and Allergy Associations (EFA) is a patients’ network representing 250,000 individuals who are members of 33 associations in 17 European countries. The aim of this Federation is to improve the health conditions and quality of life of people with asthma and allergy throughout Europe. In 1995 an EFA study clearly illustrated the need for investigations about the impact of environmental factors on the health conditions of people with asthma and allergy (EFA, 1997). It was in this light that EFA received a grant from the European Commission, DG SANCO, for the project ‘Indoor Air Pollution in Schools’. This project focussed on indoor air quality (IAQ) and its health effects (primarily asthma and allergy) in nursery, primary, and secondary schools in Europe. The objectives of this project were: to collect information on IAQ in European schools; to review policies and preventive programs of European countries in this field; to formulate recommendations aimed at providing a healthy school environment. METHODS Information on IAQ, ventilation, and building-related health problems in schools was collected, and critically reviewed and analyzed. Scientific publications were identified through computer searches of bibliographic databases. The keywords used were: air conditioning, air pollution, air pollutants, airway infections, allergens, allergy, asthma, children, environmental exposure, environmental health, exposure assessment, heating, hyperreactivity, indoor air quality, microclimate, nurseries, respiratory health, risk assessment, school building, school children, schools, ventilation, young adults. Only papers published since 1990 have been considered. The Proceedings of the most important IAQ congresses (the * Contact author email: paolo.carrer1@unimi.it Proceedings: Indoor Air 2002
Visualizing Musical Structure and Rhythm via Self-Similarity

This paper presents a novel approach to visualizing the time structure of musical waveforms. The acoustic similarity between any two instants of an audio recording is displayed in a static 2D representation, which makes structural and rhythmic characteristics visible. Unlike practically all prior work, this method characterizes self-similarity rather than specific audio attributes such as pitch or spectral features. Examples are presented for classical and popular music.
A Haefliger style description of the embedding calculus tower

Let M and N be smooth manifolds. The calculus of embeddings produces, for every k ?1, a best degree 6k polynomial approximation to the cofunctor taking an open V ! M to the space of embeddings from V to N. In this paper, a description of these polynomial approximations in terms of equivariant mapping spaces is given, for k ?2. The description is new only for k ?3. In the case k =2 we recover Hae! iger’s approximation and the known result that it is the best degree 62 approximation. ? 2002 Published by Elsevier Science Ltd. MSC: Primary 57R40; 57R52; Secondary 57S17; 58A03
Elevated serum levels of advanced glycation end products and their monocyte receptors in patients with type 2 diabetes.

BACKGROUND AND AIMS
Animal experiments showed that interaction between advanced glycation end products (AGE) and their receptors (RAGE) play an important role in the pathogenesis of diabetic complications. Soluble RAGE (sRAGE) can function as a decoy for RAGE ligands. The present study aimed to examine the levels of AGEs, RAGE and sRAGE in patients with type 2 diabetes (T2D).


METHODS
RAGE gene expression was determined by real-time PCR in 50 patients with T2D (27 men, mean age 52 ± 7.7 years) and 50 age-matched controls without T2D. Serum AGEs and sRAGEs were assayed by enzyme-linked immunosorbent assay (ELISA).


RESULTS
Serum level of AGEs was increased in patients with T2D (10.35 ± 2.27 μg/mL vs.7.69 ± 0.56 μg/mL, p <0.05). sRAGE was decreased in patients with T2D (573.6 ± 172.5 pg/mL vs. 603.4 ± 120.8 pg/mL p <0.01). RAGE gene expression was higher in T2D than in controls (p <0.01). There was an association between monocyte RAGE and serum levels of AGEs in both T2D patients (r = 0.29, p = 0.03) and controls (r = 0.31, p = 0.02). Serum AGEs correlated with homeostasis model assessment of insulin resistance (HOMA-IR) in both patients with T2D (r = 0.322, p = 0.004) and controls (r = 0.281, p = 0.003).


CONCLUSIONS
Serum AGEs and monocyte RAGE expression are increased in patients with T2D, whereas serum sRAGE is decreased. Pharmacological intervention on serum AGEs and sRAGE may be a potential therapy for diabetes.
Pattern recognition - statistical, structural and neural approaches

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Prospective validation of Baveno V definitions and criteria for failure to control bleeding in portal hypertension.

UNLABELLED
New definitions and criteria were released at the Baveno V consensus meeting. The purposes of this study were to verify Baveno V definitions and criteria for failure to control bleeding and to determine the usefulness of the combined use of the Adjusted Blood Requirement Index [ABRI: (number of blood units)/(final hematocrit-initial hematocrit)+0.01] with Baveno V criteria. In all, 246 consecutive liver cirrhosis patients with acute bleeding associated with portal hypertension were enrolled prospectively between January 2010 and October 2012. The treatment outcome on day 5 was assessed by endoscopy. For the ABRI calculation, two hematocrit levels were used as the initial hematocrit: the first level measured upon patient arrival (ABRI-A) and the lowest level measured before transfusion (ABRI-B). Treatment failures were identified in 53 patients, of whom 24 died. Based on repeated endoscopic findings, 29 patients were identified as treatment failures, while according to Baveno V criteria, 47 patients were regarded as treatment failures. The area under the receiver operating characteristic curve (AUROC) of Baveno V criteria was 0.906, and the sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio, and negative likelihood ratio were 83.0%, 98.4%, 93.6%, 95.5%, 53.41, and 0.17, respectively. The AUROC of Baveno V criteria was significantly greater than those of Baveno IV (P=0.0001) and Baveno II/III (P<0.0001) criteria. Adding ABRI-A or -B to Baveno V criteria resulted in a significant reduction of the AUROC (P<0.05).


CONCLUSION
The Baveno V criteria are good predictors of treatment failure of early-stage acute gastrointestinal bleeding in patients with portal hypertension, while the addition of ARBI does not improve the prediction accuracy of the outcome of bleeding.
Supervised prediction of drug–target interactions using bipartite local models

MOTIVATION
In silico prediction of drug-target interactions from heterogeneous biological data is critical in the search for drugs for known diseases. This problem is currently being attacked from many different points of view, a strong indication of its current importance. Precisely, being able to predict new drug-target interactions with both high precision and accuracy is the holy grail, a fundamental requirement for in silico methods to be useful in a biological setting. This, however, remains extremely challenging due to, amongst other things, the rarity of known drug-target interactions.


RESULTS
We propose a novel supervised inference method to predict unknown drug-target interactions, represented as a bipartite graph. We use this method, known as bipartite local models to first predict target proteins of a given drug, then to predict drugs targeting a given protein. This gives two independent predictions for each putative drug-target interaction, which we show can be combined to give a definitive prediction for each interaction. We demonstrate the excellent performance of the proposed method in the prediction of four classes of drug-target interaction networks involving enzymes, ion channels, G protein-coupled receptors (GPCRs) and nuclear receptors in human. This enables us to suggest a number of new potential drug-target interactions.


AVAILABILITY
An implementation of the proposed algorithm is available upon request from the authors. Datasets and all prediction results are available at http://cbio.ensmp.fr/~yyamanishi/bipartitelocal/.