LLukas22/scidocs huggingface dataset:
Multi-Label Classification: An Overview

Multi-label classification methods are increasingly required by modern applications, such as protein function classification, music categorization, and semantic scene classification. This article introduces the task of multi-label classification, organizes the sparse related literature into a structured presentation and performs comparative experimental results of certain multi-label classification methods. It also contributes the definition of concepts for the quantification of the multi-label nature of a data set.
Adherence to the Mediterranean diet and risk of metabolic syndrome and its components.

BACKGROUND AND AIMS
The role of diet in the aetiology of metabolic syndrome (MetS) is not well understood. The aim of the present study was to evaluate the relationship between adherence to the Mediterranean diet (MedDiet) and MetS.


METHODS AND RESULTS
A cross-sectional study was conducted with 808 high cardiovascular risk participants of the Reus PREDIMED Centre. MetS was defined by the updated National Cholesterol and Education Program Adult Treatment Panel III criteria. An inverse association between quartiles of adherence to the MedDiet (14-point score) and the prevalence of MetS (P for trend<0.001) was observed. After adjusting for age, sex, total energy intake, smoking status and physical activity, participants with the highest score of adherence to the MedDiet (>/=9 points) had the lowest odds ratio of having MetS (OR [95% CI] of 0.44 [0.27-0.70]) compared to those in the lowest quartile. Participants with the highest MedDiet adherence had 47 and 54% lower odds of having low HDL-c and hypertriglyceridemia MetS criteria, respectively, than those in the lowest quartile. Some components of the MedDiet, such as olive oil, legumes and red wine were associated with lower prevalence of MetS.


CONCLUSION
Higher adherence to a Mediterranean diet is associated with a significantly lower odds ratio of having MetS in a population with a high risk of cardiovascular disease.
Cryopreserved mobilized autologous blood progenitors stored for more than 2 years successfully support blood count recovery after high-dose chemotherapy.

BACKGROUND AIMS
The ability of hematopoietic progenitor cells-apheresis (HPC-A) that have been stored for many years after cryopreservation to reconstitute hematopoiesis following high-dose chemo/radiotherapy has not been well-documented.


METHODS
In this retrospective study, eight Canadian centers contributed data from 53 autologous stem cell transplants (ASCT) performed using HPC-A that had undergone long-term storage (>2 years, range 2-7 years) and 120 ASCT using HPC-A stored for <6 months (short-term storage).


RESULTS
The doses of nucleated and CD34(+) cells per kilogram recipient weight were similar between the short- (mean ± SD, 4.7 ± 4.9 × 10(8) and 6.8 ± 4.3 × 10(6), respectively) and long- (4.0 ± 4.9 × 10(8) and 6.1 ± 3.4 × 10(6), respectively) term storage groups. The median days to neutrophils (absolute neutrophil count; ANC) >0.5 × 10(9)/L (median 11 days for both short- and long-term storage) and platelets >20 × 10(9)/L (median 12 and 11 for short- and long-term storage, respectively) post-ASCT were not significantly different between the two groups. When ASCT performed with <5 × 10(6)/kg CD34(+) cells was compared there was also no difference in ANC or platelet recovery (median 12 days for both after short-term storage, and 12 and 11 days, respectively, after long-term storage). Fourteen HPC-A products stored for >5 years also showed similar count recoveries as the entire long-term storage group (median 11 days for both ANC and platelets).


CONCLUSIONS
Cryopreserved HPC-A can be stored for at least 5 years with no apparent loss in their ability to support hematopoietic reconstitution after high-dose chemotherapy.
5.8 GHz ISM band energy harvester utilizing Dickson charge pump

This paper introduces a 5.725-5.850GHz ISM band energy harvester that utilizes a Dickson charge pump to harvest enough charge to light up an LED from 50cm away with less than 1W of transmitted power. The design utilizes two arrays of dual patch antennas with a staggered feed to enable a wider radiation gain pattern.
Bag-based rapid and safe seed-train expansion method for Trichoplusia ni suspension cells

Trichoplusia ni suspension cells (High FiveTM) used in conjunction with the baculovirus vector expression system (BEVS) are regarded as potential product system of new, recombinant virus-like particle (VLP) vaccines. In order to push vaccine development and production, biomanufacturers use single-use technology whenand wherever possible. This applies to upstream processing and in particular seed-train expansion ranging from cryopreserved vials via t-flasks, spinners (respectively shake flasks) to stirred stainless steel bioreactors. The stainless steel bioreactors deliver inoculum for seed bioreactors and have been increasingly replaced by wave-mixed single-use bag bioreactors during the last 5 years [1]. The approach presented for seed-train cell expansion of High Five suspension cells is based on the Biostat CultiBag RM50 optical (Sartorius Stedim Biotech). It was used for the production of cells for long-term storage and for the expansion of cells for subsequent production experiments. For long-term storage the cells were frozen at high cell concentrations (20 40 x 10 cells x mL) in 60 mL Cryobags and stored in nitrogen at -196 °C in vapour phase. Initial experiments were aimed at the growth characterization of High Five suspension cells from a vial working cell bank (WCB). The High Five cells were grown in batch mode and in 250 mL single-use shake flasks (Corning and Sartorius Stedim Biotech) on a Certomat CT Plus shaker (Sartorius Stedim Biotech) during six days (triplicates, 27 °C, 100 rpm, 25 mm shaking diameter). Afterwards a procedure was developed in which thawed cells from a Cryobag were directly transferred into and expanded in a Biostat CultiBag RM. Under optimal process conditions (500 mL starting volume, a starting cell density of 1 x 10 cells x mL, 27 °C, rocking angle of 6 °, 20 30 rpm, 0.2 vvm, DO set point 50%) growth rate (0.039 0.042 h), doubling time (18 20 h) and maximal cell density (7.8 8.9 x 10 cells x mL) showed good correlation with results arising from CultiBags which were inoculated with cells from shake flasks. This bag-based seed-train expansion allows time saving of about one week and reduces cross-contamination, both advantages being due to omitted intermediate cultivation steps in shake flasks.
Climate of scepticism : US newspaper coverage of the science of climate change

This two-part study integrates a quantitative review of one year of US newspaper coverage of climate science with a qualitative, comparative analysis of media-created themes and frames using a social constructivist approach. In addition to an examination of newspaper articles, this paper includes a reflexive comparison with attendant wire stories and scientific texts. Special attention is given to articles constructed with and framed by rhetoric emphasising uncertainty, controversy, and climate scepticism. r 2005 Elsevier Ltd. All rights reserved.
Plasma Levels of Plasminogen Activator Inhibitor Type 1 and Vitronectin in Children With Cancer.

BACKGROUND
The plasminogen activator system controls intravascular fibrin deposition; besides, it also participates in a wide variety of physiologic and pathologic processes, including cancer.


PROCEDURE
In this study, we examined the levels of plasminogen activator inhibitor 1 (PAI-1) and vitronectin in 32 newly diagnosed pediatric patients with malignancies, determined by enzyme-linked immunosorbent assay between January 2009 and January 2010 and compared them to 35 age-matched healthy children, using SPSS 16.0 software.


RESULTS
The mean level of PAI-1 was 23.02 ± 15 (8.2-71.19) ng/mL and vitronectin was 83.10% ± 23.77% (12%-126%) in the tumor group. Thirty-five healthy children in the same age range were enrolled in the control group. The levels of PAI-1 and vitronectin were 23.63 ± 10.44 (11.67-58.85) ng/mL and 85% ± 20.85% (39%-126%), respectively. No significant difference was found between the 2 groups by independent sample t-test (P = .86 and P = .69).


CONCLUSIONS
This is a preliminary study done in children with malignancies, investigating PAI-1 and vitronectin. Further study is needed, including larger trials and tumor tissue with histopathological examination as in adults.
Modeling, Analysis, and Suppression of the Impact of Full-Scale Wind-Power Converters on Subsynchronous Damping

This paper presents modeling, analysis, and suppression of the impact of a voltage-source converter (VSC)-based full-scale wind turbine (FSWT) on subsynchronous damping in power systems. First, a detailed output impedance model of the grid-interfacing VSC is presented and analyzed under different converter operating modes, control functions, and variations in operating point. Second, the output impedance model is used to analyze the impact of the grid-interfacing VSC on the electrical damping characteristics in the subsynchronous frequency range and interactions with an electrically nearby synchronous generator. The IEEE first benchmark for subsynchronous resonance studies is used for theoretical analysis and simulation results. It is found that the grid-interfacing VSC of the FSWT can have a negative impact on overall electrical damping and there is a risk of subsynchronous torsional oscillation especially at lower frequency modes. Third, to mitigate such interactions, an active damping controller is developed to reshape the output impedance of the interfacing VSC and yield positive electrical damping at torsional modes. Time-domain simulation results are presented to validate the theoretical analysis and show the effectiveness of the proposed active damping controller.
Ханс Фрайер. Концепция «Революции справа»

The article presents an analysis of political ideas of a German conservative Hans Freyer. The author examines his concept of “revolution from the right”, its causes and differenсes from “left-wing revolutions” as well as expands on the notions of “revolution”, “people” and “state” used by the German philosopher.
A hybrid particle swarm optimization – backpropagation algorithm for feedforward neural network training

The particle swarm optimization algorithm was showed to converge rapidly during the initial stages of a global search, but around global optimum, the search process will become very slow. On the contrary, the gradient descending method can achieve faster convergent speed around global optimum, and at the same time, the convergent accuracy can be higher. So in this paper, a hybrid algorithm combining particle swarm optimization (PSO) algorithm with back-propagation (BP) algorithm, also referred to as PSO–BP algorithm, is proposed to train the weights of feedforward neural network (FNN), the hybrid algorithm can make use of not only strong global searching ability of the PSOA, but also strong local searching ability of the BP algorithm. In this paper, a novel selection strategy of the inertial weight is introduced to the PSO algorithm. In the proposed PSO–BP algorithm, we adopt a heuristic way to give a transition from particle swarm search to gradient descending search. In this paper, we also give three kind of encoding strategy of particles, and give the different problem area in which every encoding strategy is used. The experimental results show that the proposed hybrid PSO–BP algorithm is better than the Adaptive Particle swarm optimization algorithm (APSOA) and BP algorithm in convergent speed and convergent accuracy. 2006 Elsevier Inc. All rights reserved.
A New Bound on the Cyclic Chromatic Number

In 1969, Ore and Plummer defined an angular coloring as a natural extension of the Four Color Problem: a face coloring of a plane graph where faces meeting even at a vertex must have distinct colors. A natural lower bound is the maximum degree 2 of the graph. Some graphs require w2 2x colors in an angular coloring. Ore and Plummer gave an upper bound of 22, which was improved to w 5 2x by the authors with Borodin. This article gives a new upper bound of W 9 2X on the angular chromatic number. The cyclic chromatic number is the equivalent dual vertex coloring problem. 2001 Academic Press
The SIMC method for smooth PID controller tuning

The SIMC method for PID controller tuning (Skogestad 2003) has already found widespread industrial usage in Norway. This chapter gives an updated overview of the method, mainly from a user’s point of view. The basis for the SIMC method is a first-order plus time delay model, and we present a new effective method to obtain the model from a simple closed-loop experiment. An important advantage of the SIMC rule is that there is a single tuning parameter (τc) that gives a good balance between the PID parameters (Kc,τI ,τD), and which can be adjusted to get a desired trade-off between performance (“tight” control) and robustness (“smooth” control). Compared to the original paper of Skogestad (2003), the choice of the tuning parameter τc is discussed in more detail, and lower and upper limits are presented for tight and smooth tuning, respectively. Finally, the optimality of the SIMC PI rules is studied by comparing the performance (IAE) versus robustness (Ms) trade-off with the Pareto-optimal curve. The difference is small which leads to the conclusion that the SIMC rules are close to optimal. The only exception is for pure time delay processes, so we introduce the “improved” SIMC rule to improve the performance for this case. Chapter for PID book (planned: Springer, 2011, Editor: R. Vilanova) This version: September 7, 2011 Sigurd Skogestad Department of Chemical Engineering, Norwegian University of Science and Technology (NTNU), Trondheim, e-mail: skoge@ntnu.no Chriss Grimholt Department of Chemical Engineering, Norwegian University of Science and Technology (NTNU), Trondheim
Design of a Modelling Language for Information System Security Risk Management

Nowadays, security has become one of the most demanded characteristics of information systems. However, the ways to address information systems security still lack consensus and integration. On the one hand, researchers have extended various modelling languages and methods with security-oriented constructs in order to take security concerns into account throughout the development lifecycle. On the other hand, practitioners have developed risk management methods to help estimate the relative importance of security risks and the costeffectiveness of solutions to tackle them. They are mainly driven by security standards that help practitioners assess and improve the security level of their organisations. Obviously, those two families of approaches should be unified so as to maximise the return on investment of implementing security requirements, and thereby align business and information technology concerns related to security. This is the challenge that our research aims to address. This paper presents a research agenda and describes the first steps that were undertaken to achieve it: an alignment of the terminology in the risk management literature and the elaboration of a conceptual model of the risk management domain. Those results will then be inputs for the next phases, which aim to integrate security and risk management concepts in information system development methods.
Effect of Helicobacter pylori eradication on treatment of gastro-oesophageal reflux disease: a double blind, placebo controlled, randomised trial.

BACKGROUND
The role of Helicobacter pylori eradication in the management of gastro-oesophageal reflux disease (GORD) is controversial. We hypothesised that H pylori eradication leads to worsened control of reflux disease.


METHODS
Consecutive patients with weekly reflux symptoms were prospectively recruited for endoscopy and symptom evaluation. Patients were enrolled if they had H pylori infection and required long term acid suppressants. Eligible patients were randomly assigned to omeprazole triple therapy (HpE group) or omeprazole with placebo antibiotics (Hp+ group) for one week. Omeprazole 20 mg daily was given for eight weeks for healing of oesophagitis and symptom relief. This was followed by a maintenance dose of 10 mg daily for up to 12 months. The primary study end point was the probability of treatment failure within 12 months, which was defined as either incomplete resolution of symptoms or oesophagitis at the initial treatment phase, or relapse of symptoms and oesophagitis during the maintenance phase. Predictors of treatment failure were determined by Cox's proportional hazards model.


RESULTS
A total of 236 GORD patients were screened and 113 (47.9%) were positive for H pylori; 104 (92%) patients were included in the intention to treat analysis (53 in the HpE group and 51 in the Hp+ group). Thirty one patients (30%) had erosive oesophagitis at baseline. H pylori was eradicated in 98% of the HpE group and in 3.9% of the Hp+ group. Overall, 15 patients (28.3%) in the HpE group and eight patients (15.7%) in the Hp+ group had treatment failure. The 12 month probability of treatment failure was 43.2% (95% confidence interval (CI) 29.9-56.5%) in the HpE group and 21.1% (95% CI 9.9-32.3%) in the Hp+ group (log rank test, p = 0.043). In the Cox proportional hazards model, after adjustment for the covariates age, sex, erosive oesophagitis, hiatus hernia, degree of gastritis, and severity of symptoms at baseline, H pylori eradication was the only predictor of treatment failure (adjusted hazard ratio 2.47 (95% CI 1.05-5.85)).


CONCLUSION
H pylori eradication leads to more resilient GORD.
A multicenter prospective trial evaluating the ability of preoperative computed tomography scan and serum CA-125 to predict suboptimal cytoreduction at primary debulking surgery for advanced ovarian, fallopian tube, and peritoneal cancer.

OBJECTIVE
To assess the ability of preoperative computed tomography (CT) scan of the abdomen/pelvis and serum CA-125 to predict suboptimal (>1cm residual disease) primary cytoreduction in advanced ovarian, fallopian tube, and peritoneal cancer.


METHODS
This was a prospective, non-randomized, multicenter trial of patients who underwent primary cytoreduction for stage III-IV ovarian, fallopian tube, and peritoneal cancer. A CT scan of the abdomen/pelvis and serum CA-125 were obtained within 35 and 14 days before surgery, respectively. Four clinical and 20 radiologic criteria were assessed.


RESULTS
From 7/2001 to 12/2012, 669 patients were enrolled; 350 met eligibility criteria. The optimal debulking rate was 75%. On multivariate analysis, three clinical and six radiologic criteria were significantly associated with suboptimal debulking: age ≥ 60 years (p=0.01); CA-125 ≥ 500 U/mL (p<0.001); ASA 3-4 (p<0.001); suprarenal retroperitoneal lymph nodes >1cm (p<0.001); diffuse small bowel adhesions/thickening (p<0.001); and lesions >1cm in the small bowel mesentery (p=0.03), root of the superior mesenteric artery (p=0.003), perisplenic area (p<0.001), and lesser sac (p<0.001). A 'predictive value score' was assigned for each criterion, and the suboptimal debulking rates of patients who had a total score of 0, 1-2, 3-4, 5-6, 7-8, and ≥ 9 were 5%, 10%, 17%, 34%, 52%, and 74%, respectively. A prognostic model combining these nine factors had a predictive accuracy of 0.758.


CONCLUSIONS
We identified nine criteria associated with suboptimal cytoreduction, and developed a predictive model in which the suboptimal rate was directly proportional to a predictive value score. These results may be helpful in pretreatment patient assessment.
Miniature built-in multiband antennas for mobile handsets

In this paper, we propose a new design for built-in handset antennas in that metal strips as additional resonators are directly connected with a feed strip. With the new design scheme, a quad-band antenna for covering GSM900, DCS1800, PCS1900, and UMTS2000 bands and a five-band antenna for covering GSM900, DCS1800, PCS1900, UMTS2000, and ISM2450 bands for use in mobile built-in handsets are experimentally carried out. Compared with the parasitic form with a shorted strip placed away from the main radiator in the open literature, the size of the proposed antennas can be reduced by an order of 10/spl sim/20%, which is desirable since the size of mobile phones is becoming smaller according to consumer preferences. Moreover, the impedance matching for each band of the new antennas becomes easy. The new quad-band and five-band built-in handset antennas are developed within the limits of a 36/spl times/16/spl times/8 mm/sup 3/ volume. The antennas are also analyzed using the finite-difference time-domain technique. A good agreement is achieved between measurement and simulation.
Dolutegravir versus placebo in subjects harbouring HIV-1 with integrase inhibitor resistance associated substitutions: 48-week results from VIKING-4, a randomized study.

BACKGROUND
The Phase III VIKING-3 study demonstrated that dolutegravir (DTG) 50 mg twice daily was efficacious in antiretroviral therapy (ART)-experienced subjects harbouring raltegravir- and/or elvitegravir-resistant HIV-1. VIKING-4 (ING116529) included a placebo-controlled 7-day monotherapy phase to demonstrate that short-term antiviral activity was attributable to DTG.


METHODS
VIKING-4 is a Phase III randomized, double-blind study in therapy-experienced adults with integrase inhibitor (INI)-resistant virus randomized to DTG 50 mg twice daily or placebo while continuing their failing regimen (without raltegravir or elvitegravir) for 7 days (clinicaltrials.gov identifier NCT01568892). At day 8, all subjects switched to open-label DTG 50 mg twice daily and optimized background therapy including ≥1 fully active drug. The primary end point was change from baseline in plasma HIV-1 RNA at day 8.


RESULTS
The study population (n=30) was highly ART-experienced with advanced HIV disease. Patients had extensive baseline resistance to all approved antiretroviral classes. Adjusted mean change in HIV-1 RNA at day 8 was  -1.06 log10 copies/ml for the DTG arm and 0.10 log10 copies/ml for the placebo arm (treatment difference -1.16 log10 copies/ml [-1.52, -0.80]; P<0.001). Overall, 47% and 57% of subjects had plasma HIV-1 RNA <50 and <400 copies/ml at week 24, and 40% and 53% at week 48, respectively. No discontinuations due to drug-related adverse events occurred in the study.


CONCLUSIONS
The observed day 8 antiviral activity in this highly treatment-experienced population with INI-resistant HIV-1 was attributable to DTG. Longer-term efficacy (after considering baseline ART resistance) and safety during the open-label phase were in-line with the results of the larger VIKING-3 study.
Statistical Class Separation Using sEMG Features Towards Automated Muscle Fatigue Detection and Prediction

Surface Electromyography (sEMG) activity of the biceps muscle was recorded from ten subjects. Data was recorded while subjects performed isometric contraction until fatigue. The signals were segmented into three parts (Non-Fatigue, Transition-to-Fatigue and Fatigue), assisted by a fuzzy classifier using arm angle and arm oscillation as inputs. Nine features were extracted from each of the three classes to quantify the potential performance of each feature, that could aid in differentiating the three classes of muscle fatigue within the sEMG signal. Percent change was calculated between Non-Fatigue and Transition-to-Fatigue and also between Transition-toFatigue and Fatigue classes. Estimation of relative class overlap using Partition Index approach was used showing features that can best distinguish between the three classes and quantifying class separability. Results shows that the selected dominant frequency best discriminate between the classes, giving the highest average percent change of 159.37% and 64.75%. Partition Index showed small values confirming the percent change calculations.