LLukas22/scidocs huggingface dataset:
Effect of cervical spine immobilization technique on pediatric advanced airway management: a high-fidelity infant simulation model.

OBJECTIVE
Current guidelines recommend cervical spine immobilization during orotracheal intubation when traumatic injury is suspected in infants. We evaluated the effect of cervical spine immobilization techniques on orotracheal intubation performance with a high-fidelity infant simulator.


METHODS
A randomized control study with repeated measurement. Nonanesthesia pediatric practitioners certified for intubation performed 6 intubations with 3 different cervical spine immobilization techniques (no physical protection, manual in-line immobilization, and cervical collar: C-collar). Time to accomplish key actions, cervical extension angle, and observed intubation associated events such as mainstem intubation, esophageal intubation with or without immediate recognition were recorded.


RESULTS
Twenty-six practitioners performed 156 successful orotracheal intubation. Time to intubation from end of mask assist ventilation was 29.0 +/- 12.2 seconds in no physical protection, 33.0 +/- 17.4 seconds in C-collar, and 33.0 +/- 17.1 seconds in manual in-line immobilization (P = 0.39). Maximal cervical extension angle in no physical protection (2.39 +/- 2.56 degrees ) and C-collar (2.65 +/- 1.79 degrees ) were significantly greater compared with 0.85 +/- 1.05 degrees in manual in-line immobilization (P < 0.0001). The number of intubation attempts and intubation associated events were not different among 3 techniques. Laryngeal visualization measured by Cormack-LehaneScale was more difficult in C-collar compared with other 2 techniques (P< 0.001).


CONCLUSIONS
In this high-fidelity infant simulator model, cervical spine immobilization technique affected cervical extension angle and laryngeal visualization. Tracheal intubation associated events occurred in 33% of intubation attempts but were not different by technique. Time to achieve tracheal intubation, number of intubation attempts needed to succeed, and intubation-associated events were not affected by immobilization techniques. These results support Advanced Trauma Life Support recommendations to perform manual in-line immobilization in infants.
Mortality, sudden death and indication for cardioverter defibrillator implantation in a dialysis population.

BACKGROUND
The incidence of sudden death among dialysis patients is high, but end stage renal disease was an exclusion criterion in the trials that demonstrated the benefit of implantable cardioverter defibrillator (ICD) for sudden death prevention.


METHODS
Dialysis patients alive on January 2010 or starting dialysis between January 2010 and January 2013 were enrolled and retrospectively evaluated. Patients were divided into three groups: No-Indication, Indication-With ICD and Indication-Without ICD. Cox and Fine and Gray regression models were used to estimate the total and cause-specific (sudden or non-sudden) mortality hazard ratio (HR, HR(cpRisk)), respectively. Survival was defined as the time from start of dialysis to the time of death.


RESULTS
154/2072 patients (7.4%) had indication for ICD implantation and 52 (33.8%) of them received the device; 688 (33.2%) deaths were recorded. Mortality was different among groups [Indication-With ICD vs No-Indication: HR 1.59 (95% CI 1.06-2.38) and Indication-Without ICD vs No-Indication: HR 2.67 (95% CI 2.09-3.39, p < 0.001)]. 84/688 (12.2%) were sudden deaths. The cumulative incidence of sudden death was higher in patients with ICD indication [Indication-With ICD vs No-Indication HR(cpRisk) 3.21 (95% CI 1.38-7.40) and Indication-Without ICD vs No-Indication: HR(cpRisk) 4.19 (95% CI 2.38-7.39), p < 0.001], but also No-Indication patients showed a high rate of sudden death [8.5% (95% CI.6.5-10.9) at 8 years of follow-up].


CONCLUSIONS
Dialysis patients with ICD indication had a worse survival than No-Indication subjects and the prognosis was particularly poor for the Indication-Without ICD group. Sudden death incidence was much higher than in the general population, even among No-Indication subjects.
LICAVAL: combination therapy in acute and maintenance treatment of bipolar disorder

BACKGROUND
The challenge of Bipolar Disorder (BD) treatment is due to the complexity of the disease. Current guidelines represent an effort to help clinicians in their everyday practice but still have limitations, specially concerning to long term treatment. LICAVAL (efficacy and tolerability of the combination of LIthium and CArbamazepine compared to lithium and VALproic acid in the treatment of young bipolar patients) study aim to evaluate acute and maintenance phase of BD treatment with two combined drugs.


METHODS
LICAVAL is a single site, parallel group, randomized, outcome assessor blinded trial. BD I patients according to the DSM-IV-TR, in depressive, manic,/hypomanic or mixed episode, aged 18 to 35 years are eligible. After the diagnostic assessments, the patients are allocated for one of the groups of treatment (lithium + valproic acid or lithium + carbamazepine). Patients will be followed up for 8 weeks in phase I (acute treatment), 6 months in phase II (continuation treatment) and 12 months in phase III (maintenance treatment). Outcome assessors are blind to the treatment. The main outcome is the evaluation of changes in mean scores on CGI-BP-M between baseline and endpoint at the end of each phase of the study.


RESULTS
LICAVAL is currently in progress, with patients in phase I, II or III. It will extended until august 2012.


CONCLUSIONS
Trials comparing specific treatments efficacy in BD (head to head) can show relevant information in clinical practice. Long term treatment is an issue of great important and should be evaluated carefully in more studies as long as BD is a chronic disease.


TRIAL REGISTRATION
ClinicalTrials.gov Identifier: NCT00976794.
Small Square Monopole Antenna for UWB Applications With Variable Frequency Band-Notch Function

In this letter, a novel printed monopole antenna (PMA) for ultrawideband (UWB) applications with variable frequency band-notch characteristic is presented. The proposed antenna consists of a stepped square radiating patch with two U-shaped slots and a notched ground plane with a T-shaped sleeve that provides a wide usable fractional bandwidth of more than 140% (2.8516.73 GHz). By cutting two modified U-shaped slots with variable dimensions on the radiating patch, frequency band-stop performance is generated, and we can control its characteristics such as band-notch frequency and its bandwidth. The designed antenna has a small size of 12 times 19 mm2 while showing the band rejection performance in the frequency band of 5.02-5.97 GHz.
Micro-optics for liquid crystal displays applications

Micro-optics have become the key technology in liquid crystal display systems due to its capabilities of miniaturization and design flexibility. Design consideration and experimental results of microoptical components for enhancing the image quality, providing better functions, increasing light efficiency, and generating 3D images in liquid crystal display (LCD) applications are presented.
Calibrated Fairness in Bandits

We study fairness within the stochastic,multi-armed bandit (MAB) decision making framework. We adapt the fairness framework of “treating similar individuals similarly” [5] to this seing. Here, an ‘individual’ corresponds to an arm and two arms are ‘similar’ if they have a similar quality distribution. First, we adopt a smoothness constraint that if two arms have a similar quality distribution then the probability of selecting each arm should be similar. In addition, we dene the fairness regret, which corresponds to the degree to which an algorithm is not calibrated, where perfect calibration requires that the probability of selecting an arm is equal to the probability with which the arm has the best quality realization. We show that a variation on ompson sampling satises smooth fairness for total variation distance, and give an Õ((kT )2/3) bound on fairness regret. is complements prior work [12], which protects an on-average beer arm from being less favored. We also explain how to extend our algorithm to the dueling bandit seing. ACM Reference format: Yang Liu, Goran Radanovic, Christos Dimitrakakis, DebmalyaMandal, andDavid C. Parkes. 2017. Calibrated Fairness in Bandits. In Proceedings of FAT-ML, Calibrated Fairness in Bandits, September 2017 (FAT-ML17), 7 pages. DOI: 10.1145/nnnnnnn.nnnnnnn
Drinking motives in clinical and general populations.

AIMS
This paper had three aims: (1) to validate a Spanish adaptation of the Modified Drinking Motives Questionnaire-Revised (M DMQ-R), (2) to explore the relationship of each drinking motive with different patterns of alcohol use, and (3) to compare the drinking motives of moderate drinkers, heavy drinkers, and alcohol abusing/dependent individuals.


METHODS
Two studies were carried out. In Study 1, a sample of 488 participants completed the M DMQ-R and a self-report scale of alcohol consumption in order to study the factor structure and different indices of reliability and validity of the Spanish M DMQ-R. In Study 2, we compared the drinking motives of moderate and heavy drinkers from Study 1 and an additional sample of 59 clinical drinkers.


RESULTS
The M DMQ-R demonstrated sound reliability and validity indices. Coping-with-anxiety, social, and enhancement motives predicted higher alcohol use on weekends, but only coping-with-anxiety and social motives were related to consumption on weekdays. Furthermore, moderate drinkers had the lowest scores for all motives, whereas alcohol-dependent participants obtained the highest scores for negative reinforcement drinking motives.


CONCLUSION
The Spanish M DMQ-R is a reliable and valid measure of drinking motives and has potential for assisting with treatment planning for problem drinkers.
Risk-taking propensity as a predictor of induction onto naltrexone treatment for opioid dependence.

OBJECTIVE
Heroin addiction is a chronic relapsing disorder that has devastating social, medical, and economic consequences. Naltrexone is an antagonist that blocks opioid effects and could be an effective medication for the treatment of opioid dependence. However, its clinical utility has been limited partly because of poor adherence and acceptability. Given the importance of compliance to naltrexone treatment for opioid dependence, the goal of the current study was to examine predictors involved in successful induction onto naltrexone treatment.


METHOD
Parametric and nonparametric statistical tests were performed on data from a sample of 64 individuals entering treatment who met DSM-IV criteria for opioid dependence. The relationship between naltrexone induction (ie, inducted vs not inducted onto naltrexone) and risk-taking propensity, as indexed by riskiness on the Balloon Analogue Risk Task (BART), was examined. Participants were recruited from local detoxification programs, inpatient drug treatment, and other Baltimore programs that provided services to opioid-dependent adults (eg, Baltimore Needle Exchange Program) during the period from August 2007 to September 2008.


RESULTS
Positive association was shown between risk-taking propensity and odds of naltrexone induction. Specifically, each 5-point increase in the total BART score was associated with a 25% decrease in odds of naltrexone induction (OR = 0.76; 95% CI, 0.58-0.99; P = .041). This association remained statistically significant, even after adjusting for potential confounds, including injection drug use and cocaine positive urine results (P = .05). After adjusting for the covariates, each 5-point increase in BART score was associated with 28% decrease in the odds of achieving the maintenance dose (adjusted OR = 0.73; 95% CI, 0.54-0.99; P = .046).


CONCLUSIONS
Risk-taking propensity was predictive of induction onto naltrexone treatment, above and beyond injection drug use and cocaine-positive urine samples.
Care of patients with a diagnosis of chronic obstructive pulmonary disease: a cluster randomised controlled trial.

OBJECTIVE
To evaluate a partnership model of care for patients with a diagnosis of chronic obstructive pulmonary disease (COPD).


DESIGN, SETTING AND PARTICIPANTS
Cluster randomised controlled trial with blinded outcome assessment of 44 general practices in south-western Sydney comprising 451 people with a diagnosis of COPD, conducted between 2006 and 2009.


INTERVENTION
Participants from intervention group practices were visited at their home by a registered nurse with specific training in COPD care who worked with the general practitioner, the patient and other health professionals to develop and implement an individualised care plan based on best-practice guidelines. Participants from control group practices received usual care.


MAIN OUTCOME MEASURES
The primary outcome was disease-related quality of life measured using the St George's Respiratory Questionnaire (SGRQ) at 12-month follow-up. Other outcomes were overall quality of life, lung function, smoking status, immunisation status, patient knowledge of COPD, and health service use.


RESULTS
Of the 451 participants, 257 (57.8%) were confirmed as having COPD on post-bronchodilator spirometry. Follow-up was completed for 330 patients (73.2%). At 12 months, there was no statistically significant difference in the mean SGRQ scores between intervention and control groups (38.7 v 37.6; difference, 1.1; 95% CI, - 1.53-3.74; P = 0.41) or in measures of quality of life, lung function and smoking status. Compared with the control group, in the intervention group, attendance at pulmonary rehabilitation was more frequent (31.1% v 9.6%; OR, 5.16; 95% CI, 2.40-11.10; P = 0.002) and the mean COPD knowledge score was higher (10.5 v 9.8; difference, 0.70; CI, 0.10-1.21; P = 0.02).


CONCLUSION
The nurse-GP partnership intervention did not have an impact on disease-related quality of life at 12-month follow-up. However, there was evidence of improved quality of care, in particular, in attendance at pulmonary rehabilitation and patient knowledge of COPD.


TRIAL REGISTRATION
Australian Clinical Trials Registry ACTRN012606000304538.
Chronic Constipation with Megacolon

A 61-year-old female with long-standing constipation presented with increasing abdominal distention, pain, nausea and weight loss. She had been previously treated with intermittent fiber supplements and osmotic laxatives for chronic constipation. She did not use medications known to cause delayed bowel transit. Examination revealed a distended abdomen, hard stool in the rectum, and audible heart sounds throughout the abdomen. A CT scan showed severe colonic distention from stool (Fig. 1). She had no mechanical, infectious, metabolic, or endocrine-related etiology for constipation. After failing conservative management including laxative suppositories, enemas, manual disimpaction, methylnaltrexone and neostigmine, the patient underwent a colectomy with Hartmann pouch and terminal ileostomy. The removed colon measured 25.5 cm in largest diameter and weighed over 15 kg (Fig. 2). The histopathological examination demonstrated no neuronal degeneration, apoptosis or agangliosis to suggest Hirschprung’s disease or another intrinsic neuro-muscular disorder. Idiopathic megacolon is a relatively uncommon condition usually associated with slow-transit constipation. Although medical therapy is frequently ineffective, rectal laxatives, gentle enemas, and manual disimpaction can be attempted. Oral osmotic or secretory laxatives as well as unprepped lower endoscopy are relative contraindications as they may precipitate a perforation. Surgical therapy is often required as most cases are refractory to medical therapy.
On Embedding a Microarchitectural Design Language within Haskell

Based on our experience with modelling and verifying microarchitectural designs within Haskell, this paper examines our use of Haskell as host for an embedded language. In particular, we highlight our use of Haskell's lazy lists, type classes, lazy state monad, and unsafe Perform I0, and point to several areas where Haskell could be improved in the future. We end with an example of a benefit gained by bringing the functional perspective to microarchitectural modelling.
The Effect of Insulin Infusion on the Metabolites in Cerebral Tissues Assessed With Proton Magnetic Resonance Spectroscopy in Young Healthy Subjects With High and Low Insulin Sensitivity

OBJECTIVE
Insulin may play important roles in brain metabolism. Proton magnetic resonance spectroscopy ((1)H-MRS) of the central nervous system gives information on neuronal viability, cellular energy, and membrane status. To elucidate the specific role of insulin action in the brain, we estimated neurometabolites with (1)H-MRS and assessed their regulation by insulin infusion and their relationship with insulin sensitivity.


RESEARCH DESIGN AND METHODS
We studied 16 healthy young men. (1)H-MRS was performed at baseline and after 240 min of euglycemic-hyperinsulinemic clamp. Voxels were positioned in the left frontal lobe, left temporal lobe, and left thalamus. The ratios of N-acetylaspartate (NAA), choline-containing compounds (Cho), myo-inositol, and glutamate/glutamine/γ-aminobutyric acid complex (Glx) to creatine (Cr) and nonsuppressed water signal were determined. The participants were divided into subgroups of high (high IS) and low (low IS) insulin sensitivity.


RESULTS
Baseline neurometabolic substrates were not different between the groups. Insulin infusion resulted in an increase in frontal NAA/Cr and NAA/H2O and frontal and temporal Glx/Cr and Glx/H2O and a decrease in frontal Cho/Cr and temporal Cho/H2O and myo-inositol/H2O (all P < 0.05, except temporal Glx/H2O, P = 0.054, NS) in the high-IS, but not in the low-IS, group. Insulin sensitivity correlated positively with frontal NAA/Cr and NAA/H2O and temporal Glx/H2O and negatively with temporal myo-inositol/Cr and myo-inositol/H2O assessed during the second (1)H-MRS (all P < 0.05).


CONCLUSIONS
Insulin might influence cerebral metabolites, and this action is impaired in subjects with low whole-body insulin sensitivity. Thus, our results provide a potential link between insulin resistance and altered metabolism of the central nervous system.
Fusion of perceptual cues for robust tracking of head pose and position

The paradigm of perceptual fusion provides robust solutions to computer vision problems. By combining the outputs of multiple vision modules, the assumptions and constraints of each module are factored out to result in a more robust system overall. The integration of di!erent modules can be regarded as a form of data fusion. To this end, we propose a framework for fusing di!erent information sources through estimation of covariance from observations. The framework is demonstrated in a face and 3D pose tracking system that fuses similarity-to-prototypesmeasures and skin colour to track head pose and face position. The use of data fusion through covariance introduces constraints that allow the tracker to robustly estimate head pose and track face position simultaneously. 2001 Pattern Recognition Society. Published by Elsevier Science Ltd. All rights reserved.
Assessing the performance of German Bundesliga football players: a non-parametric metafrontier approach

This article presents a novel model for evaluating the performance of field players in football. Based upon Data Envelopment Analysis (DEA), we employ a nonconcave metafrontier approach that permits estimation of players’ efficiency scores under consideration of their playing positions. The model is applied to a data set of Germany’s premier league football players covering the playing seasons 2002/03 to 2008/09. The results reveal a clear positive relationship between a team’s average player efficiency score and its rank in the league table at the end of the season. In addition, the metafrontier approach is used to identify a footballer’s optimal playing position in the team and to quantify the performance increase from moving to that position.
Osteopathic manual therapy versus conventional conservative therapy in the treatment of temporomandibular disorders: a randomized controlled trial.

OBJECTIVE
Temporomandibular disorders (TMD) is a term reflecting chronic, painful, craniofacial conditions usually of unclear etiology with impaired jaw function. The effect of osteopathic manual therapy (OMT) in patients with TMD is largely unknown, and its use in such patients is controversial. Nevertheless, empiric evidence suggests that OMT might be effective in alleviating symptoms. A randomized controlled clinical trial of efficacy was performed to test this hypothesis.


METHODS
We performed a randomized, controlled trial that involved adult patients who had TMD. Patients were randomly divided into two groups: an OMT group (25 patients, 12 males and 13 females, age 40.6+/-11.03) and a conventional conservative therapy (CCT) group (25 patients, 10 males and 15 females, age 38.4+/-15.33). At the first visit (T0), at the end of treatment (after six months, T1) and two months after the end of treatment (T2), all patients were subjected to clinical evaluation. Assessments were performed by subjective pain intensity (visual analogue pain scale, VAS), clinical evaluation (Temporomandibular index) and measurements of the range of maximal mouth opening and lateral movement of the head around its axis.


RESULTS
Patients in both groups improved during the six months. The OMT group required significantly less medication (non-steroidal medication and muscle relaxants) (P<0.001).


CONCLUSIONS
The two therapeutic modalities had similar clinical results in patients with TMD, even if the use of medication was greater in CCT group. Our findings suggest that OMT is a valid option for the treatment of TMD.
Improved motion-based localized super resolution technique using discrete wavelet transform for low resolution video enhancement

Super resolution is used for resolution enhancement of images or video sequences. Instead of super resolving frames globally, using localized motion based super resolution increases the quality of the enhanced frames. In this paper, we propose to use the super resolution on different subbands of localized moving regions extracted from discrete wavelet transform (DWT) and composing the super resolved subbands using inverse DWT (IDWT) to generate the respective enhanced high resolution frame. The results based on PSNR values, in comparison with the global super resolution method, show improvement in quality. The improvement is achieved by isolating different frequencies in different subbands extracted from DWT and super resolving them separately.
Highly purified hMG versus recombinant FSH in ovarian hyperstimulation with GnRH antagonists--a randomized study.

BACKGROUND
Highly purified hMG (hp-hMG) has recently shown better cycle outcome than the recombinant FSH (rFSH) when compared in GnRH agonist long protocol cycles. However, they have not yet been compared in GnRH antagonist cycles.


METHODS
A RCT comparing the ongoing pregnancy rate (primary end-point) in 280 patients undergoing IVF/ICSI after stimulation with hp-hMG or rFSH controlled with a GnRH antagonist.


RESULTS
No significant differences were observed between hp-hMG and rFSH in terms of the ongoing pregnancy rate per started cycle (35.0 versus 32.1%, respectively; P = 0.61); relative risk: 1.09 (95% confidence interval: 0.78-1.51; risk difference: 2.9%). No differences were observed for implantation, clinical pregnancy and pregnancy loss rates. More oocytes were obtained from patients receiving rFSH then hMG (14.4 +/- 8.1 versus 11.3 +/- 6.0, respectively; P = 0.001). Estradiol was higher at the end of stimulation in the hp-hMG group (P = 0.02), whereas progesterone was higher in patients stimulated with rFSH (P < 0.001).


CONCLUSIONS
A similar outcome was observed for hp-hMG and rFSH when used for stimulation in GnRH antagonist cycles. However, some differences were found in ovarian response in terms of oocyte yield and hormonal profile. Clinical Trials.gov


TRIAL REGISTRATION NUMBER
NCT00669786.