LLukas22/scidocs huggingface dataset:
High frequency repetitive transcranial magnetic stimulation (rTMS) is effective in migraine prophylaxis: an open labeled study.

OBJECTIVE
To evaluate the effect of high rate repetitive transcranial magnetic stimulation (rTMS) in migraine prophylaxis in medically refractory patients.


METHODS
Migraine patients above 15 years of age, having more than 7 attacks/month and refractory to at least two prophylactic drugs were included. The patients were evaluated for migraine frequency, severity, functional disability, number of rescue medications and migraine index. Three sessions of alternate day 10 Hz rTMS comprising of 600 pulses in 10 trains were delivered to left frontal cortex. The response was evaluated at the end of session and weekly for 4 weeks.


RESULTS
Fifty-one patients aged 16-61 years and 45 females were treated. Fifty (98%) patients had more than 50% reduction of headache frequency at the end and 1 week after rTMS and the improvement persisted till the fourth week in 80.4% patients. The headache frequency, severity, functional disability, migraine index, and rescue medications significantly reduced at all time points, but the maximum benefit was observed in the first 2 weeks. There were no serious adverse events.


CONCLUSION
High rate rTMS in left frontal cortex is effective and well tolerated for migraine prophylaxis.
Significant differential effects of lower doses of hormone therapy or tibolone on markers of cardiovascular disease in post-menopausal women: a randomized, double-blind, crossover study.

AIMS
We have previously reported that lower doses of hormone therapy (L-HT) and tibolone have different effects on markers of cardiovascular disease when compared with conventional doses of HT. The objective was to compare the effects of L-HT and tibolone on lipid profile, vasodilation, and factors associated with inflammation and haemostasis.


METHODS AND RESULTS
Forty-one women received a combination of micronized progesterone 100 mg with conjugated equine estrogen 0.3 mg vs. tibolone 2.5 mg alone daily in random order during 2 months with 2 months washout period. When compared with L-HT, tibolone significantly reduced total cholesterol (P<0.001), triglyceride (P<0.001), HDL cholesterol (P<0.001) levels, and triglyceride/HDL cholesterol ratios (P=0.004) except total cholesterol/HDL cholesterol ratios. Tibolone improved flow-mediated response to hyperaemia from baseline values (P<0.001) by a similar magnitude to L-HT. L-HT and tibolone did not increase high-sensitivity C-reactive protein relative to baseline values. L-HT reduced antithrombin III from baseline values (P=0.037), compared with tibolone showing no changes. However, there was no difference between either. In contrast, tibolone increased pro-thrombin fragment 1+2 (F1+2) from baseline values (P=0.002), compared with L-HT showing no changes. Tibolone significantly reduced plasma plasminogen activator inhibitor type 1 (PAI-1) antigen levels from baseline values (P=0.004), compared with L-HT showing no changes. The effects of L-HT and tibolone on F1+2 and PAI-1 were significantly different (P=0.045 and P=0.008, respectively).


CONCLUSION
Both tibolone and L-HT improved flow-mediated response by a similar magnitude and did not significantly increase high-sensitivity C-reactive protein. However, tibolone significantly reduced PAI-1, but increased F1+2 more than L-HT.
Training practitioners to deliver opportunistic multiple behaviour change counselling in primary care: a cluster randomised trial

OBJECTIVES
To evaluate the effect of training primary care health professionals in behaviour change counselling on the proportion of patients self reporting change in four risk behaviours (smoking, alcohol use, exercise, and healthy eating).


DESIGN
Cluster randomised trial with general practices as the unit of randomisation.


SETTING
General practices in Wales.


PARTICIPANTS
53 general practitioners and practice nurses from 27 general practices (one each at all but one practice) recruited 1827 patients who screened positive for at least one risky behaviour.


INTERVENTION
Behaviour change counselling was developed from motivational interviewing to enable clinicians to enhance patients' motivation to change health related behaviour. Clinicians were trained using a blended learning programme called Talking Lifestyles.


MAIN OUTCOME MEASURES
Proportion of patients who reported making beneficial changes in at least one of the four risky behaviours at three months.


RESULTS
1308 patients from 13 intervention and 1496 from 14 control practices were approached: 76% and 72% respectively agreed to participate, with 831 (84%) and 996 (92%) respectively screening eligible for an intervention. There was no effect on the primary outcome (beneficial change in behaviour) at three months (362 (44%) v 404 (41%), odds ratio 1.12 (95% CI 0.90 to 1.39)) or on biochemical or biometric measures at 12 months. More patients who had consulted with trained clinicians recalled consultation discussion about a health behaviour (724/795 (91%) v 531/966 (55%), odds ratio 12.44 (5.85 to 26.46)) and intended to change (599/831 (72%) v 491/996 (49%), odds ratio 2.88 (2.05 to 4.05)). More intervention practice patients reported making an attempt to change (328 (39%) v 317 (32%), odds ratio 1.40 (1.15 to 1.70)), a sustained behaviour change at three months (288 (35%) v 280 (28%), odds ratio 1.36 (1.11 to 1.65)), and reported slightly greater improvements in healthy eating at three and 12 months, plus improved activity at 12 months. Training cost £1597 per practice.


DISCUSSION
Training primary care clinicians in behaviour change counselling using a brief blended learning programme did not increase patients reported beneficial behaviour change at three months or improve biometric and a biochemical measure at 12 months, but it did increase patients' recollection of discussing behaviour change with their clinicians, intentions to change, attempts to change, and perceptions of having made a lasting change at three months. Enduring behaviour change and improvements in biometric measures are unlikely after a single routine consultation with a clinician trained in behaviour change counselling without additional intervention.


TRIAL REGISTRATION
ISRCTN 22495456.
Why data citation is a computational problem

Using database views to define citable units is the key to specifying and generating citations to data.
Underestimation of cognitive impairment by Mini-Mental State Examination versus the Montreal Cognitive Assessment in patients with transient ischemic attack and stroke: a population-based study.

BACKGROUND AND PURPOSE
The Mini-Mental State Examination (MMSE) is insensitive to mild cognitive impairment and executive function. The more recently developed Montreal Cognitive Assessment (MoCA), an alternative, brief 30-point global cognitive screen, might pick up more cognitive abnormalities in patients with cerebrovascular disease.


METHODS
In a population-based study (Oxford Vascular Study) of transient ischemic attack and stroke, the MMSE and MoCA were administered to consecutive patients at 6-month or 5-year follow-up. Accepted cutoffs of MMSE <27 and MoCA <26 were taken to indicate cognitive impairment.


RESULTS
Of 493 patients, 413 (84%) were testable. Untestable patients were older (75.5 versus 69.9 years, P<0.001) and often had dysphasia (24%) or dementia (15%). Although MMSE and MoCA scores were highly correlated (r(2)=0.80, P<0.001), MMSE scores were skewed toward higher values, whereas MoCA scores were normally distributed: median and interquartile range 28 (26 to 29) and 23 (20 to 26), respectively. Two hundred ninety-one of 413 (70%) patients had MoCA <26 of whom 162 had MMSE > or =27, whereas only 5 patients had MoCA > or =26 and MMSE <27 (P<0.0001). In patients with MMSE > or =27, MoCA <26 was associated with higher Rankin scores (P=0.0003) and deficits in delayed recall, abstraction, visuospatial/executive function, and sustained attention.


CONCLUSIONS
The MoCA picked up substantially more cognitive abnormalities after transient ischemic attack and stroke than the MMSE, demonstrating deficits in executive function, attention, and delayed recall.
Slotted Microstrip Antennas for Circular Polarization with Compact Size

Circularly polarized diagonally symmetric slotted microstrip-patch antennas are proposed with compact size. The compact circularly polarized (CP) diagonally symmetric slotted microstrip-patch (DSSMP) antenna design rules are also summarized. Circularly polarized radiation can be achieved using any arbitrarily shaped slots in diagonal directions on the square microstrip-patch antenna. Different shapes for the slots are studied and compared, based on the fixed overall volume of the antenna for circularly polarized diagonally symmetric slotted microstrip-patch antennas. The cross-shaped-slot diagonally symmetric slotted microstrip-patch antenna is compact when compared with the circular-, square-, and circular-ring-shaped diagonally symmetric slotted microstrip-patch antennas. A measured 3 dB axial-ratio (AR) bandwidth of around 0.7% (6.0 MHz) with 2.0% (18.0 MHz) impedance bandwidth was achieved. The measured boresight gain was more than 3.3 dBic over the operating band, while the overall antenna size was 0.272λ0 × 0.272λ0 × 0.0138λ0 at 0.905 GHz.
Real-time three-dimensional guided ultrasound targeting system for microwave ablation of liver tumours: a human pilot study.

OBJECTIVES
This study aimed to evaluate a novel three-dimensional ultrasound (US) guidance system for use in hepatic microwave ablation (MWA).


METHODS
An in vitro assessment was performed in which users with different degrees of experience were evaluated for accuracy in targeting phantom lesions embedded in agar using US alone, or US in conjunction with the InVision™ System (IVS). An eight-patient pilot trial of the IVS was then performed in the setting of open hepatic MWA, in which lesions would otherwise have been targeted with conventional US.


RESULTS
In vitro studies demonstrated that the IVS significantly improved targeting accuracy at all levels of operator experience (novice, beginner and expert). In the human trial, a total of 31 tumours were targeted and all lesions were hit in one pass, as assessed by independent US image observations. There were no adverse operative events; however, there was minor line-of-sight interference with the infra-red tracking mechanism when some lesions high on the dome of the liver were targeted.


CONCLUSIONS
The IVS significantly increased the accuracy of complex targeting procedures of phantom lesions and enhanced targeting in an eight-patient clinical pilot study. During the accrual phase of this pilot study, the development of improved non-optical tracking hardware obviated the requirement to maintain a direct line of sight. The trial was then halted prematurely in order to focus on the application of the IVS utilizing this non-optical modality.
Electro-tactile feedback system to enhance virtual reality experience

Virtual Reality (VR) has been proven to be capable of enabling its users to experience immersive virtual environments and interact with the computer. Most VR applications utilize stereo visual perception, however, stereo visual perception alone is not enough to fully immerse users in VR environments. Haptic feedback technology when applied to VR applications can offer improved immersion and interactivity and can extend the range of sensations experienced by the user. For example, tactile feedback can enable the user to feel an object they touch with their virtual hand or body. To provide tactile feedback in VR applications most researchers construct cumbersome mechanical actuators and linkages for applying feedback forces or vibrations to the user's real hand or body. Having to wear cumbersome feedback hardware can have the negative effect of making the user more aware of their physical body which can reduce the sense of being immersed in the VR world. To overcome this drawback we propose an alternative feedback system which is comprised of a hand gesture interface, a stereo visual head-set and an electro-tactile feedback system. Our electro-tactile feedback system is compact, simple, inexpensive and capable of delivering a variety of feedback sensations to the user. Experimental results are provided which demonstrate how the electro-tactile feedback system can enhance both the sense of immersion and interactivity for VR users.
5W GaN MMIC for Millimeter-Wave Applications

Power amplifier MMICs were designed and fabricated using micro-strip topology on 3-mil thinned semi-insulating SiC substrates with through vias. A two-stage 50-ohm matched Ka-band MMIC with an output-stage composed of a 1.2-mm-wide device operated with Psat of 5 Watts at 26.5 GHz, corresponding to a power density of 3.1 W/mm, with an associated gain of 9dB and a PAE of 20%. The MMIC produced 13 plusmn1dB of linear gain from 25GHz to 30GHz with an associated P3dB of > 3 watts across the band. These results are the best combination of output power and power density reported from a Ka-band GaN MMIC to date
Impact of postdilatation on performance of bioresorbable vascular scaffolds in patients with acute coronary syndrome compared with everolimus-eluting stents: A propensity score-matched analysis from a multicenter "real-world" registry.

BACKGROUND
Safety and efficacy of bioresorbable vascular scaffolds (BRS) and the role of postdilatation on outcome in acute coronary syndrome (ACS) patients compared with those of everolimus-eluting stents (EES) remain unknown. The aim of the study is to compare the safety and efficacy of BRS with EES in ACS and to investigate the role of BRS postdilatation.


METHODS
Consecutive ACS patients undergoing BRS implantation in 8 centers were com-pared with those with EES before and after propensity score matching. Major adverse cardiac event (MACE), myocardial infarction, and target lesion revascularization (TLR) were the primary endpoint. Sensitivity analysis was performed according to postdilatation after BRS implantation. We enrolled 303 BRS and 748 EES patients; 215 from each group were com-pared after matching, and 117 (55.2%) BRS patients were treated with postdilatation.


RESULTS
After a median follow-up of 24.0 months, MACE rates were higher in BRS patients than in EES patients (9.3% vs. 4.7%, p < 0.001), mainly driven by TLR (6.1% vs. 1.9%, p < 0.001). Stent thrombosis increased in the BRS group (2.8% vs. 0.9%, p = 0.01). How-ever, after sensitivity analysis, MACE rates in BRS patients with postdilatation were signifi-cantly lower than in those without, comparable to EES patients (6.0% vs. 12.6% vs. 4.7%, p < 0.001). The same trend was observed for TLR (3.4% vs. 8.4% vs. 1.9%, p < 0.001). Stent thrombosis rates were higher in both the BRS groups than in EES patients (2.6% vs. 3.2% vs. 0.9%, p = 0.045).


CONCLUSIONS
Postdilatation appears effective when using BRS in ACS patients. MACE rates are comparable to those of EES, although scaffold thrombosis is not negligible. Randomized prospective studies are required for further investigation.
Parsing Clothes in Unrestricted Images

Parsing for clothes in images and videos is a critical step towards understanding the human appearance. In this work, we propose a method to segment clothes in settings where there is no restriction on number and type of clothes, pose of the person, viewing angle, occlusion and number of people. This is a challenging task as clothes, even of the same category, have large variations in color and texture. The presence of human joints is the best indicator for cloth types as most of the clothes are consistently worn around the joints. We incorporate the human joint prior by estimating the body joint distributions using the detectors and learning the cloth-joint co-occurrences of different cloth types with respect to body joints. The cloth-joint and cloth-cloth co-occurrences are used as a part of the conditional random field framework to segment the image into different clothing. Our results indicate that we have outperformed the recent attempt [16] on H3D [3], a fairly complex dataset.
Pilot Study to Evaluate Feasibility of Image-Guided Breast-Conserving Therapy in the Advanced Multimodal Image-Guided Operating (AMIGO) Suite

The rate of reexcision in breast-conserving surgery remains high, leading to delay in initiation of adjuvant therapy, increased cost, increased complications, and negative psychological impact to the patient.1 – 3 We initiated a phase 1 clinical trial to determine the feasibility of the use of intraoperative magnetic resonance imaging (MRI) to assess margins in the advanced multimodal image-guided operating (AMIGO) suite. All patients received contrast-enhanced three-dimensional MRI while under general anesthesia in the supine position, followed by standard BCT with or without wire guidance and sentinel node biopsy. Additional margin reexcision was performed of suspicious margins and correlated to final pathology (Fig. 1). Feasibility was assessed via two components: demonstration of safety and sterility and acceptable duration of the operation and imaging; and adequacy of intraoperative MRI imaging for interpretation and its comparison to final pathology. Fig. 1 Schema of AMIGO trial Eight patients (mean age 48.5 years), 4 with stage I breast cancer and 4 with stage II breast cancer, were recruited. All patients underwent successful BCT in the AMIGO suite with no AMIGO-specific complications or break in sterility during surgery. The mean operative time was 113 min (range 93–146 min). Our experience with AMIGO suggests that it is feasible to use intraoperative MRI imaging to evaluate margin assessment in real time. Further research is required to identify modalities that will lead to a reduction in reexcision in breast cancer therapy.
Forecasting Dengue Haemorrhagic Fever Cases in Southern Thailand using ARIMA Models

A univariate time-series analysis method has been used to model and forecast the monthly number of dengue haemorrhagic fever (DHF) cases in southern Thailand. We developed autoregressive integrated moving average (ARIMA) models on the data collected between 1994–2005 and then validated the models using the data collected between January–August 2006. The results showed that the regressive forecast curves were consistent with the pattern of actual values. The ARIMA (1,0,1) model fitting was adequate for the data with the Q-statistic (Q=4.446). This indicated that the autocorrelation function was not significantly different for zero.
A Bayesian analysis of the multinomial probit model using marginal data augmentation

We introduce a set of new Markov chain Monte Carlo algorithms for Bayesian analysis of the multinomial probit model. Our Bayesian representation of the model places a new, and possibly improper, prior distribution directly on the identi0able parameters and thus is relatively easy to interpret and use. Our algorithms, which are based on the method of marginal data augmentation, involve only draws from standard distributions and dominate other available Bayesian methods in that they are as quick to converge as the fastest methods but with a more attractive prior speci0cation. C-code along with an R interface for our algorithms is publicly available. c © 2004 Elsevier B.V. All rights reserved. JEL classi$cation: C11; C25; C35
CHAPTER 14 Security and Fraud Detection in Mobile and Wireless Networks

The fusion of computer and telecommunication technologies has heralded the age of information superhighway over wireline and wireless networks. Mobile cellular communication systems and wireless networking technologies are growing at an ever-faster rate, and this is likely to continue in the foreseeable future. Wireless technology is presently being used to link portable computer equipment to corporate distributed computing and other sources of necessary information. Wide-area cellular systems and wireless LANs promise to make integrated networks a reality and provide fully distributed and ubiquitous mobile communications, thus bringing an end to the tyranny of geography. Higher reliability, better coverage and services, higher capacity, mobility management, power and complexity for channel acquisition, handover decisions, security management, and wireless multimedia are all parts of the potpourri. Further increases in network security are necessary before the promise of mobile telecommunication can be fulfilled. Safety and security management against fraud, intrusions, and cloned mobile phones, just to mention a few, will be one of the major issues in the next wireless and mobile generations. A “safe” system provides protection against errors of trusted users, whereas a “secure” system protects against errors introduced by impostors and untrusted users [1]. Therefore, rather than ignoring the security concerns of potential users, merchants, and telecommunication companies need to acknowledge these concerns and deal with them in a straightforward manner. Indeed, in order to convince the public to use mobile and wireless technology in the next and future generations of wireless systems, telecom companies and all organizations will need to explain how they have addressed the security of their mobile/wireless systems. Manufacturers, M-business, service providers, and entrepreneurs who can visualize this monumental change and effectively leverage their experiences on both wireless and Internet will stand to benefit from it. Concerns about network security in general (mobile and wired) are growing, and so is research to match these growing concerns. Indeed, since the seminal work by D. Denning [9] in 1981, many intrusion-detection prototypes, for instance, have been created. Intrusion-detection systems aim at detecting attacks against computer systems and wired net-
Diffraction at edges in planar impedance surfaces: revisited exact solutions at skew incidence

In this paper, the revisited exact solutions are presented for the electromagnetic problems of a half plane with surface impedance faces and a surface impedance edge discontinuity on a plane, when they are illuminated at skew incidence. They are obtained by introducing a suitable new set of combined spectra that exhibit all the desired properties. As a consequence, the final expressions of the spectra satisfy all the Malyuzhinets method conditions, the edge conditions, explicitly satisfy reciprocity and nicely reduce to the original Malyuzhinets solution for normal incidence. The importance of the achieved symmetry with respect to incidence and observation aspects, is further emphasized in extending the solutions to dipole source illuminations.