LLukas22/scidocs huggingface dataset:
Brain-inspired computing exploiting carbon nanotube FETs and resistive RAM: Hyperdimensional computing case study

We demonstrate an end-to-end brain-inspired hyperdimensional (HD) computing nanosystem, effective for cognitive tasks such as language recognition, using heterogeneous integration of multiple emerging nanotechnologies. It uses monolithic 3D integration of carbon nanotube field-effect transistors (CNFETs, an emerging logic technology with significant energy-delay product (EDP) benefit vs. silicon CMOS [1]) and Resistive RAM (RRAM, an emerging memory that promises dense non-volatile and analog storage [2]). Due to their low fabrication temperature (<250°C), CNFETs and RRAM naturally enable monolithic 3D integration with fine-grained and dense vertical connections (exceeding various chip stacking and packaging approaches) between computation and storage layers using back-end-of-line inter-layer vias [3]. We exploit RRAM and CNFETs to create area-and energy-efficient circuits for HD computing: approximate accumulation circuits using gradual RRAM reset operation (in addition to RRAM single-bit storage) and random projection circuits that embrace inherent variations in RRAM and CNFETs. Our results demonstrate: 1. pairwise classification of 21 European languages with measured accuracy of up to 98% on >20,000 sentences (6.4 million characters) per language pair. 2. One-shot learning (i.e., learning from few examples) using one text sample (∼100,000 characters) per language. 3. Resilient operation (98% accuracy) despite 78% hardware errors (circuit outputs stuck at 0 or 1). Our HD nanosystem consists of 1,952 CNFETs integrated with 224 RRAM cells.
Airway sensory replacement combined with nicotine replacement for smoking cessation. A randomized, placebo-controlled trial using a citric acid inhaler.

STUDY OBJECTIVE
This study was conducted to determine if the combination of airway sensory replacement and nicotine replacement improves 10-week smoking abstinence rates over nicotine replacement alone.


DESIGN
Double-blind, randomized, placebo-controlled trial.


SETTING
Outpatient research clinic.


PARTICIPANTS
One hundred healthy volunteers who smoked at least one pack of cigarettes per day and desired to quit smoking.


INTERVENTIONS
Subjects received either citric acid (n = 41) or lactose placebo (n = 59) inhalers to cope with smoking urges for 10 weeks. All subjects received self-help materials and nicotine patches for 6 weeks. Return visits were at weeks 1, 4, 6, and 10. Abstinence was defined as zero cigarettes smoked since the quit date verified by exhaled carbon monoxide < or = 8 ppm at all return visits. Inhaler effects were measured by a standardized questionnaire.


MEASUREMENTS AND RESULTS
The primary outcome of continuous abstinence at the end of the 10-week treatment period was 19.5% (95% confidence interval [CI] = 7.4 to 31.6%) for the citric acid group vs 6.8% (95% CI = 0.4 to 13.2%) for the lactose group (p = 0.05). Relief from craving and short-term abstinence increased as airway sensations from the inhaler also increased. Abstinence at 10 weeks for subjects receiving strong airway sensations from the inhalers was 33.3% (95% CI = 14.5 to 52.1%). At 6 months, there was no difference in abstinence between the treatment groups (0% vs 5.1%, p = 0.20).


CONCLUSIONS
When combined with the nicotine patch, the citric acid inhaler improved 10-week smoking abstinence over lactose inhaler. The combination of airway sensory replacement and nicotine replacement may prove beneficial for smoking cessation.
An abductive event calculus planner

Abstract In 1969 Cordell presented his seminal description of planning as theorem proving with the situation calculus. The most pleasing feature of Green's account was the negligible gap between high-level logical specification and practical implementation. This paper attempts to reinstate the ideal of planning via theorem proving in a modern guise. In particular, the paper shows that if we adopt the event calculus as our logical formalism and employ abductive logic programming as our theorem proving technique, then the computation performed mirrors closely that of a hand-coded partial-order planning algorithm. Soundness and completeness results for this logic programming implementation are given. Finally the paper shows that, if we extend the event calculus in a natural way to accommodate compound actions, then using the same abductive theorem proving techniques we can obtain a hierarchical planner.
Lipoblastoma/lipoblastomatosis: a clinicopathologic study of 16 cases in Taiwan

Lipoblastoma/lipoblastomatosis is an uncommon benign lipomatous tumor affecting mainly infants and children. It presents as a painless mass located frequently in upper and lower extremities. The present study was conducted to characterize the clinicopathologic features of lipoblastoma/lipoblastomatosis in a Chinese population. A retrospective survey of 16 cases of pathologically confirmed lipoblastoma/lipoblastomatosis from 1988 to 2002 was performed. The available clinical information and histological sections were reviewed. The study involved 10 males and 6 females ranging in age from 5 to 49 months (median, 11.5 months). The patients presented with mass involving neck (n=5), inguina (n=3), feet (n=2), arm (n=1), leg (n=1), thorax (n=1), mesentery (n=1), buttock (n=1), and presacral region(n=1). The lesions were removed surgically. Histologically, the majority (11/16) of primary tumors were of diffuse type. Follow-up ranging from 5 to 125 months was available in 13 patients. Four patients experienced a recurrence of tumors in the neck (n=2) and lower extremities (n=2) 11–84 months after operation. The most common site of involvement of lipoblastoma/lipoblastomatosis in our series was the neck. A follow-up period of more than 3 years is recommended for patients with this condition.
English phonology and morphology

1 Introduction The title of this chapter poses a daunting challenge, since the morphophonology of present-day English is one of the most intensively studied areas in the whole of morphology and phonology. Indeed, as key innovations in phonological and morphological theory have been introduced, they have frequently been illustrated by means of case-studies from English: this is true not only for classical rule-based generative phonology (Chomsky & Halle, 1968; henceforth SPE), but more recently for connectionist and dual-It follows that we must define our aims somewhat narrowly. First, then, this chapter focuses on interactions between phonology and morphology in present-day English and their implications for the shape of the morphology-phonology interface in natural language. Perforce, we disregard phonology-syntax interactions, although clearly some key facts and concepts in morphophonology have close phonosyntactic analogues. Our data are drawn from both British and American dialects, standard and vernacular, though obviously no variety is exhaustively described. We focus on facts that have figured prominently in the wider theoretical debate, but also pay some attention to phenomena that seem peculiar to English. Even the latter, however, underscore points of general relevance: as we shall see in section 3.5, for example, some of the idiosyncrasies of present-day English morphophonology are the product of historical contingencies; this illustrates how, when contending with the effects of diachrony, morphophonological theory routinely encounters historically conditioned facts that it can note but not explain. From a theoretical viewpoint, we concentrate on major conceptions of the morphology-phonology interface, abstracting away from other dimensions of variation between theories. Wherever possible, therefore, our presentation is neutral between rule-based and constraint-based systems, with 'rule' simply meaning 'symbolic generalization' unless otherwise stated or required by context. We accordingly ignore the differences between rule-based Lexical
Network Error Correction With Unequal Link Capacities

This paper studies the capacity of single-source single-sink noiseless networks under adversarial or arbitrary errors on no more than z edges. Unlike prior papers, which assume equal capacities on all links, arbitrary link capacities are considered. Results include new upper bounds, network error-correction coding strategies, and examples of network families where our bounds are tight. An example is provided of a network where the capacity is 50% greater than the best rate that can be achieved with linear coding. While coding at the source and sink suffices in networks with equal link capacities, in networks with unequal link capacities, it is shown that intermediate nodes may have to do coding, nonlinear error detection, or error correction in order to achieve the network error-correction capacity.
The Universe in the Logunov Metric

Exact solutions of the Lagrange equations in the Logunov metric are found in the context of classical gravitation theory.
Practical parallax occlusion mapping with approximate soft shadows for detailed surface rendering

(a) (b) Figure 1. Realistic city scene rendered using parallax occlusion mapping applied to the cobblestone sidewalk in (a) and using the normal mapping technique in (b).
Scaffolding in tissue engineering: general approaches and tissue-specific considerations

Scaffolds represent important components for tissue engineering. However, researchers often encounter an enormous variety of choices when selecting scaffolds for tissue engineering. This paper aims to review the functions of scaffolds and the major scaffolding approaches as important guidelines for selecting scaffolds and discuss the tissue-specific considerations for scaffolding, using intervertebral disc as an example.
From simple interrupted to complex spiral: a systematic review of various suture techniques for microvascular anastomoses.

Accomplishing successful microvascular anastomoses is undoubtedly one of the most critical steps in performing free tissue transfer. However, the ideal technique has often been a subject of debate. Therefore, our objective was to review the current literature in an attempt to find objective evidence supporting the superiority of one particular technique. A PubMed and OVID on-line search was performed in November 2007 using the following keywords: microvascular anastomoses, microsurgical anastomosis, continuous suture, interrupted suture, mattress suture, and sleeve anastomosis. Our literature review found no difference in short- and/or long-term patency rates between the six main published techniques, which includes continuous suture, interrupted suture, locking continuous, continuous horizontal, horizontal interrupted with eversion, and sleeve anastomoses. These findings were consistent for each technique as long as the microsurgeon maintained standard microsurgical principles and practice, including suture line eversion, minimized tension, and direct intima-to-intima contact. Current literature supports no overall statistical difference in short- and/or long-term patency rates between any of the various techniques. The choice to perform one suture technique over another ultimately depends on the plastic surgeon's preference and microsurgical experience. To date, there are no human randomized, controlled clinical trials comparing the efficacy and clinical outcomes of each of the various suture techniques, and therefore one's comfort and familiarity should dictate his or her microsurgical technique. However, "exposure to many and mastery of one" simply provides the plastic surgery resident, fellow, or staff the technical flexibility needed for less-complicated surgical planning when performing free tissue transfer.
Diagnosis and treatment of patients with stroke in a mobile stroke unit versus in hospital: a randomised controlled trial

BACKGROUND
Only 2-5% of patients who have a stroke receive thrombolytic treatment, mainly because of delay in reaching the hospital. We aimed to assess the efficacy of a new approach of diagnosis and treatment starting at the emergency site, rather than after hospital arrival, in reducing delay in stroke therapy.


METHODS
We did a randomised single-centre controlled trial to compare the time from alarm (emergency call) to therapy decision between mobile stroke unit (MSU) and hospital intervention. For inclusion in our study patients needed to be aged 18-80 years and have one or more stroke symptoms that started within the previous 2·5 h. In accordance with our week-wise randomisation plan, patients received either prehospital stroke treatment in a specialised ambulance (equipped with a CT scanner, point-of-care laboratory, and telemedicine connection) or optimised conventional hospital-based stroke treatment (control group) with a 7 day follow-up. Allocation was not masked from patients and investigators. Our primary endpoint was time from alarm to therapy decision, which was analysed with the Mann-Whitney U test. Our secondary endpoints included times from alarm to end of CT and to end of laboratory analysis, number of patients receiving intravenous thrombolysis, time from alarm to intravenous thrombolysis, and neurological outcome. We also assessed safety endpoints. This study is registered with ClinicalTrials.gov, number NCT00153036.


FINDINGS
We stopped the trial after our planned interim analysis at 100 of 200 planned patients (53 in the prehospital stroke treatment group, 47 in the control group), because we had met our prespecified criteria for study termination. Prehospital stroke treatment reduced the median time from alarm to therapy decision substantially: 35 min (IQR 31-39) versus 76 min (63-94), p<0·0001; median difference 41 min (95% CI 36-48 min). We also detected similar gains regarding times from alarm to end of CT, and alarm to end of laboratory analysis, and to intravenous thrombolysis for eligible ischaemic stroke patients, although there was no substantial difference in number of patients who received intravenous thrombolysis or in neurological outcome. Safety endpoints seemed similar across the groups.


INTERPRETATION
For patients with suspected stroke, treatment by the MSU substantially reduced median time from alarm to therapy decision. The MSU strategy offers a potential solution to the medical problem of the arrival of most stroke patients at the hospital too late for treatment.


FUNDING
Ministry of Health of the Saarland, Germany, the Werner-Jackstädt Foundation, the Else-Kröner-Fresenius Foundation, and the Rettungsstiftung Saar.
Phase I study of bevacizumab added to fluorouracil- and hydroxyurea-based concomitant chemoradiotherapy for poor-prognosis head and neck cancer.

PURPOSE
We conducted a phase I dose escalation study to determine the maximum-tolerated dose (MTD) and dose-limiting toxicity (DLT) of bevacizumab, when added to the standard FHX (fluorouracil [FU], hydroxyurea [HU], radiation) chemoradiotherapy platform in poor-prognosis head and neck cancer (HNC) patients.


PATIENTS AND METHODS
Patients with recurrent, previously radiated or poor-prognosis, treatment-naive HNC were eligible. Treatment was repeated every 14 days for seven cycles: Bevacizumab was escalated 2.5 to 10 mg/kg, FU 600 to 800 mg/m(2) (120 hours continuous infusion), and hydroxyurea from 500 to 1,000 mg (twice daily for 5 days), starting day 1. At the MTD, the cohort was expanded.


RESULTS
Forty-three patients were treated. DLT was reached at level 3 (bevacizumab 5 mg/kg, FU 800 mg/m(2), HU 1,000 mg) with two grade 3 transaminase elevations and one grade 4 neutropenia, attributed to the combination of chemotherapy with bevacizumab. For level 4, chemotherapy doses were reduced (FU 600 mg/(2), HU 500 mg), and bevacizumab escalation continued to 10 mg/kg. Treatment of six assessable patients resulted in one venous thrombosis; this dose level was expanded to 26 patients. Late complications included five patients with fistula formation (11.6%) and four with ulceration/tissue necrosis (9.3%). Serious toxicities (hemorrhage/thrombosis/death) were comparable to prior reirradiation reports. Median overall survival for reirradiated patients with recurrent, nonmetastatic disease was 10.3 months [95% CI, 5.6 to 13.5]; 2-year cumulative incidence of death resulting from disease was 51.7% (95% CI, 31.7 to 68.5).


CONCLUSION
Bevacizumab can be integrated with FHX chemoradiotherapy at a dose of 10 mg/m(2) every 2 weeks with decreased chemotherapy doses because of neutropenia. The regimen shows antitumor activity. Observed fistula formation/tissue necrosis may be bevacizumab related, and further investigation should proceed with careful monitoring.
A Phase I Trial of the Anti-KIR Antibody IPH2101 and Lenalidomide in Patients with Relapsed/Refractory Multiple Myeloma.

PURPOSE
Natural killer (NK) cells may play an important role in the immune response to multiple myeloma; however, multiple myeloma cells express killer immunoglobulin-like receptor (KIR) ligands to prevent NK cell cytotoxicity. Lenalidomide can expand and activate NK cells in parallel with its direct effects against multiple myeloma; however, dexamethasone may impair these favorable immunomodulatory properties. IPH2101, a first-in-class antiinhibitory KIR antibody, has acceptable safety and tolerability in multiple myeloma as a single agent. The present work sought to characterize lenalidomide and IPH2101 as a novel, steroid-sparing, dual immune therapy for multiple myeloma.


EXPERIMENTAL DESIGN
A phase I trial enrolled 15 patients in three cohorts. Lenalidomide was administered per os at 10 mg on cohort 1 and 25 mg on cohorts 2 and 3 days 1 to 21 on a 28-day cycle with IPH2101 given intravenously on day 1 of each cycle at 0.2 mg/kg in cohort 1, 1 mg/kg in cohort 2, and 2 mg/kg in cohort 3. No corticosteroids were utilized. The primary endpoint was safety, and secondary endpoints included clinical activity, pharmacokinetics (PK), and pharmacodynamics (PD).


RESULTS
The biologic endpoint of full KIR occupancy was achieved across the IPH2101 dosing interval. PD and PK of IPH2101 with lenalidomide were similar to data from a prior single-agent IPH2101 trial. Five serious adverse events (SAE) were reported. Five objective responses occurred. No autoimmunity was seen.


CONCLUSIONS
These findings suggest that lenalidomide in combination with antiinhibitory KIR therapy warrants further investigation in multiple myeloma as a steroid-sparing, dual immune therapy. This trial was registered at www.clinicaltrials.gov (reference: NCT01217203).
Effects of occupational exposure in pesticide plant on workers' serum and erythrocyte cholinesterase activity.

OBJECTIVES
The determination of cholinesterase activity has been commonly applied in the biomonitoring of exposure to organophosphates and carbamates and in the diagnosis of poisoning with anticholinesterase compounds. One of the groups who are at risk of pesticide intoxication are the workers engaged in the production of these chemicals.


AIMS
The aim of this study was to assess the effect of pesticides on erythrocyte and serum cholinesterase activity in workers occupationally exposed to these chemicals.


METHODS
The subjects were 63 workers at a pesticide plant. Blood samples were collected before they were employed (phase I) and after 3 months of working in the plant (phase II). Cholinesterase level in erythrocytes (EChE) was determined using the modified Ellman method, and serum cholinesterase (SChE) by butyrylthiocholine substrate assay.


RESULTS
The mean EChE levels were 48+/-11 IU/g Hb in phase I and 37+/-17 IU/g Hb in phase II (paired t-test, mean=-29; 95% CI=-43-14), p<0.001). The mean SChE level was 9569+/-2496 IU/l in phase I, and 7970+/-2067 IU/l in phase II (paired t-test, mean=1599; 95% CI=1140-2058, p<0.001). There was a significant increase in ALT level (p < 0.001) and a decrease in serum albumin level (p<0.001).


CONCLUSION
In view of the significant decrease in EChE and SChE levels among pesticide workers, it seems that routine assessment of cholinesterase level in workers employed in such occupations and people handling pesticides should be made obligatory.
A review of data mining applications in crime

Crime continues to remain a severe threat to all communities and nations across the globe alongside the sophistication in technology and processes that are being exploited to enable highly complex criminal activities. Data mining, the process of uncovering hidden information from Big Data, is now an important tool for investigating, curbing and preventing crime and is exploited by both private and government institutions around the world. The primary aim of this paper is to provide a concise review of the data mining applications in crime. To this end, the paper reviews over 100 applications of data mining in crime, covering a substantial quantity of research to date, presented in chronological order with an overview table of many important data mining applications in the crime domain as a reference directory. The data mining techniques themselves are briefly introduced to the reader and these include entity extraction, clustering, association rule mining, decision trees, support vector machines, naive Bayes rule, neural networks and social network analysis amongst others. © 2016 Wiley Periodicals, Inc. Statistical Analysis and Data Mining: The ASA Data Science Journal 9: 139–154, 2016
Effect of astaxanthin supplementation on muscle damage and oxidative stress markers in elite young soccer players.

AIM
The purpose of the current study was to examine the effect of Astaxanthin (Asx) supplementation on muscle enzymes as indirect markers of muscle damage, oxidative stress markers and antioxidant response in elite young soccer players.


METHODS
Thirty-two male elite soccer players were randomly assigned in a double-blind fashion to Asx and placebo (P) group. After the 90 days of supplementation, the athletes performed a 2 hour acute exercise bout. Blood samples were obtained before and after 90 days of supplementation and after the exercise at the end of observational period for analysis of thiobarbituric acid-reacting substances (TBARS), advanced oxidation protein products (AOPP), superoxide anion (O2•¯), total antioxidative status (TAS), sulphydril groups (SH), superoxide-dismutase (SOD), serum creatine kinase (CK) and aspartate aminotransferase (AST).


RESULTS
TBARS and AOPP levels did not change throughout the study. Regular training significantly increased O2•¯ levels (main training effect, P<0.01). O2•¯ concentrations increased after the soccer exercise (main exercise effect, P<0.01), but these changes reached statistical significance only in the P group (exercise x supplementation effect, P<0.05). TAS levels decreased significantly post- exercise only in P group (P<0.01). Both Asx and P groups experienced increase in total SH groups content (by 21% and 9%, respectively) and supplementation effect was marginally significant (P=0.08). Basal SOD activity significantly decreased both in P and in Asx group by the end of the study (main training effect, P<0.01). All participants showed a significant decrease in basal CK and AST activities after 90 days (main training effect, P<0.01 and P<0.001, respectively). CK and AST activities in serum significantly increased as result of soccer exercise (main exercise effect, P<0.001 and P<0.01, respectively). Postexercise CK and AST levels were significantly lower in Asx group compared to P group (P<0.05)


CONCLUSION
The results of the present study suggest that soccer training and soccer exercise are associated with excessive production of free radicals and oxidative stress, which might diminish antioxidant system efficiency. Supplementation with Asx could prevent exercise induced free radical production and depletion of non-enzymatic antioxidant defense in young soccer players.