LLukas22/scidocs huggingface dataset:
Paricalcitol- or cinacalcet-centred therapy affects markers of bone mineral disease in patients with secondary hyperparathyroidism receiving haemodialysis: results of the IMPACT-SHPT study.

BACKGROUND
In this Phase 4 international study, efficacy and safety of paricalcitol-centred therapy were compared with that of cinacalcet-centred therapy for the treatment of chronic kidney disease (CKD)-associated secondary hyperparathyroidism (SHPT) in patients undergoing haemodialysis (ClinicalTrials.gov identifier NCT00977080).


METHODS
Patients ≥ 18 years of age with Stage 5 CKD and SHPT [intact parathyroid hormone (iPTH) level of 300-800 pg/mL, calcium level of 8.4-10.0 mg/dL and phosphate concentration of ≤ 6.5 mg/dL] who were undergoing haemodialysis were included. Patients were randomized by mode of paricalcitol administration [i.e. intravenous (IV) or oral strata] to receive paricalcitol- or cinacalcet-centred therapy for ≤ 28 weeks. Changes in metabolic markers [total alkaline phosphatase (AP), bone-specific AP and fibroblast growth factor-23 (FGF-23)] and the proportion of patients in each treatment group who achieved an iPTH level of 150-300 pg/mL during Weeks 8, 16 and 21-28 as a composite value were evaluated.


RESULTS
Compared with cinacalcet-centred therapy, levels of both bone turnover markers were significantly reduced from baseline with IV and oral paricalcitol-centred treatment (P < 0.05 for both dosing strata) at Weeks 8, 16 and 28. Levels of FGF-23 were increased with paricalcitol versus cinacalcet-centred treatment. A greater proportion of patients receiving paricalcitol-centred therapy achieved target iPTH levels (i.e. 150-300 pg/mL) throughout the study in the IV and oral dosing strata compared with patients receiving cinacalcet-centred treatment.


CONCLUSIONS
In patients with CKD and SHPT undergoing haemodialysis, paricalcitol-centred therapy reduced circulating bone turnover markers and iPTH levels and increased FGF-23 levels compared with cinacalcet-centred treatment.


TRIAL REGISTRATION
ClinicalTrials.gov identifier NCT00977080.
Do Functional Movement Screen (FMS) composite scores predict subsequent injury? A systematic review with meta-analysis.

AIM
This paper aims to systematically review studies investigating the strength of association between FMS composite scores and subsequent risk of injury, taking into account both methodological quality and clinical and methodological diversity.


DESIGN
Systematic review with meta-analysis.


DATA SOURCES
A systematic search of electronic databases was conducted for the period between their inception and 3 March 2016 using PubMed, Medline, Google Scholar, Scopus, Academic Search Complete, AMED (Allied and Complementary Medicine Database), CINAHL (Cumulative Index to Nursing and Allied Health Literature), Health Source and SPORTDiscus.


ELIGIBILITY CRITERIA FOR SELECTING STUDIES
Inclusion criteria: (1) English language, (2) observational prospective cohort design, (3) original and peer-reviewed data, (4) composite FMS score, used to define exposure and non-exposure groups and (5) musculoskeletal injury, reported as the outcome.


EXCLUSION CRITERIA
(1) data reported in conference abstracts or non-peer-reviewed literature, including theses, and (2) studies employing cross-sectional or retrospective study designs.


RESULTS
24 studies were appraised using the Quality of Cohort Studies assessment tool. In male military personnel, there was 'strong' evidence that the strength of association between FMS composite score (cut-point ≤14/21) and subsequent injury was 'small' (pooled risk ratio=1.47, 95% CI 1.22 to 1.77, p<0.0001, I2=57%). There was 'moderate' evidence to recommend against the use of FMS composite score as an injury prediction test in football (soccer). For other populations (including American football, college athletes, basketball, ice hockey, running, police and firefighters), the evidence was 'limited' or 'conflicting'.


CONCLUSION
The strength of association between FMS composite scores and subsequent injury does not support its use as an injury prediction tool.


TRIAL REGISTRATION NUMBER
PROSPERO registration number CRD42015025575.
Thinking about the self influences thinking in general : cognitive consequences of salient self-concept

Two studies support our hypothesis that connected and interdependent self-focus evokes a generally context-dependent cognitive mode (focused on object–context relations) and provide some evidence that separate and independent self-focus evokes a generally context-independent cognitive mode (focused on objects, independent of contexts). Consistent with our predictions, experimental manipulation of interdependent self-focus influences cognitive speed/accuracy (Experiment 1) and memory (Experiment 2). When primed self-focus is congruent with the perceptual task at hand, perceptual speed increases (as shown by a significant task by prime interaction effect) and when primed, interdependent self-focus improves memory for incidentally encoded contextual information. Further research to link primed and chronic self-focus effects is called for. 2002 Elsevier Science (USA). All rights reserved.
Transport Layer Security (TLS) Extensions

Transport Layer Security (TLS) Extensions Status of this Memo This document specifies an Internet standards track protocol for the Internet community, and requests discussion and suggestions for improvements. Please refer to the current edition of the "Internet Official Protocol Standards" (STD 1) for the standardization state and status of this protocol. Distribution of this memo is unlimited. Abstract This document describes extensions that may be used to add functionality to Transport Layer Security (TLS). It provides both generic extension mechanisms for the TLS handshake client and server hellos, and specific extensions using these generic mechanisms. The extensions may be used by TLS clients and servers. The extensions are backwards compatible-communication is possible between TLS 1.0 clients that support the extensions and TLS 1.0 servers that do not support the extensions, and vice versa. Conventions used in this Document The key words "MUST", "MUST NOT", "REQUIRED", "SHALL", "SHALL NOT", "SHOULD", "SHOULD NOT", "RECOMMENDED", "MAY", and "OPTIONAL" in this document are to be interpreted as described in BCP 14, RFC 2119 [KEYWORDS].
Uniqueness, Continuity, and Existence of Implicit Functions in Constructive Analysis

We extract a quantitative variant of uniqueness from the usual hypotheses of the implicit functions theorem. This leads not only to an a priori proof of continuity, but also to an alternative, fully constructive existence proof.
The Power of Anonymization and Sensitive Knowledge Hiding Using Sanitization Approach

In recent day’s huge rapid growth of corporate industries professional are based on the online marketing. These markets are associated with millions of online transactions which contain the details of the items, number of items, price and additional information like working details, salary information and personal information. The customers associated with these transactions are concerned about privacy issues. This manuscript aims to concentrates more on the additional information about the customer apart from dealing with the items. More analysis helps in knowing the sensitive information about an individual. In this article two algorithms were used, out of which first algorithm has been used to hide the sensitive information about an individual and other proposed algorithm has been used to hide the sensitive transaction information. These algorithms are proposed based on k-Anonymity and association rule hiding techniques. A novel algorithm has been proposed for association rule hiding algorithm to reduce the side effects such as Sensitive item-set hiding failure, Non-sensitive misses, extra item-set generations and Database dissimilarities along with the reduction of running time and complexities through transaction deletion.
Penguin amplitudes: charming contributions

We briefly introduce the Wick-contraction parametrization of hadronic matrix elements and discuss some applications to B and K physics.
Effectiveness of low-Dye taping for the short-term treatment of plantar heel pain: a randomised trial

BACKGROUND
Plantar heel pain is one of the most common musculoskeletal disorders of the foot and ankle. Treatment of the condition is usually conservative, however the effectiveness of many treatments frequently used in clinical practice, including supportive taping of the foot, has not been established. We performed a participant-blinded randomised trial to assess the effectiveness of low-Dye taping, a commonly used short-term treatment for plantar heel pain.


METHODS
Ninety-two participants with plantar heel pain (mean age 50 +/- 14 years; mean body mass index 30 +/- 6; and median self-reported duration of symptoms 10 months, range of 2 to 240 months) were recruited from the general public between February and June 2005. Participants were randomly allocated to (i) low-Dye taping and sham ultrasound or (ii) sham ultrasound alone. The duration of follow-up for each participant was one week. No participants were lost to follow-up. Outcome measures included 'first-step' pain (measured on a 100 mm Visual Analogue Scale) and the Foot Health Status Questionnaire domains of foot pain, foot function and general foot health.


RESULTS
Participants treated with low-Dye taping reported a small improvement in 'first-step' pain after one week of treatment compared to those who did not receive taping. The estimate of effect on 'first-step' pain favoured the low-Dye tape (ANCOVA adjusted mean difference -12.3 mm; 95% CI -22.4 to -2.2; P = 0.017). There were no other statistically significant differences between groups. Thirteen participants in the taping group experienced an adverse event however most were mild to moderate and short-lived.


CONCLUSION
When used for the short-term treatment of plantar heel pain, low-Dye taping provides a small improvement in 'first-step' pain compared with a sham intervention after a one-week period.
Hard evidence on soft skills.

This paper summarizes recent evidence on what achievement tests measure; how achievement tests relate to other measures of "cognitive ability" like IQ and grades; the important skills that achievement tests miss or mismeasure, and how much these skills matter in life. Achievement tests miss, or perhaps more accurately, do not adequately capture, soft skills-personality traits, goals, motivations, and preferences that are valued in the labor market, in school, and in many other domains. The larger message of this paper is that soft skills predict success in life, that they causally produce that success, and that programs that enhance soft skills have an important place in an effective portfolio of public policies.
Optimal fuzzy pid controller design of an active magnetic bearing system based on adaptive genetic algorithms

This paper proposes an adaptive genetic algorithm (AGA) for the multi-objective optimization design of a fuzzy PID controller and applies it to the control of an active magnetic bearing (AMB) system. Different from PID controllers with fixed gains, the fuzzy PID controller is expressed in terms of fuzzy rules whose rule consequences employ analytical PID expressions. The PID gains are adaptive and the fuzzy PID controller has more flexibility and capability than the conventional ones. Moreover, it can be easily utilized to develop a precise and fast control algorithm in optimal design. An adaptive genetic algorithm is proposed to design the fuzzy PID controller. The centers of the triangular membership functions and the PID gains for all fuzzy control rules are selected as parameters to be determined. The dynamic model of AMB system for axial motion is also presented. The simulation results of this AMB system show that a fuzzy PID controller designed via the proposed AGA has good performance.
Representing and classifying arguments on the Semantic Web

Until recently, little work has been dedicated to the representation and interchange of informal, semistructured arguments of the type found in natural language prose and dialogue. To redress this, the research community recently initiated work towards an Argument Interchange Format (AIF). The AIF aims to facilitate the exchange of semi-structured arguments among different argument analysis and argumentation-support tools. In this paper, we present a Description Logic ontology for annotating arguments, based on a new reification of the AIF and founded in Walton’s theory of argumentation schemes. We demonstrate how this ontology enables a new kind of automated reasoning over argument structures, which complements classical reasoning about argument acceptability. In particular, Web Ontology Language reasoning enables significantly enhanced querying of arguments through automatic scheme classifications, instance classification, inference of indirect support in chained argument structures, and inference of critical questions. We present the implementation of a pilot Web-based system for authoring and querying argument structures using the proposed ontology.
Translation and linguistic validation of the FACT-EGFRI-18 quality of life instrument from English into Dutch.

PURPOSE
The Functional Assessment of Cancer Therapy-Epidermal Growth Factor Receptor Inhibitor 18 (FACT-EGFRI-18) is a patient-reported outcomes questionnaire developed to assess the effect of EGFRI on patients. The FACT-EGFR-18 was translated into Dutch and evaluated in order to document that the translation adequately captures the concepts of the original English-language version of the questionnaire and is readily understood by subjects in the target population.


METHOD
Translation of the FACT-EGFRI-18 from English to Dutch was accomplished by employing the Functional Assessment of Chronic Illness Therapy (FACIT) multilingual translation methodology. Ten native-speaking residents of the target country who reported EGFRI associated dermatological adverse events (dAEs) were asked to review the translation of the harmonized FACT-EGFRI-18.


RESULTS
Participants generally found the Dutch FACT-EGFRI-18 easy to understand and complete. In addition, the translation retained the original meaning of the FACT-EGFRI-18 items and instructions. Based on the results of the cognitive debriefing interviews, no changes to improve clarity and comprehension of translations were identified.


CONCLUSIONS
The Dutch FACT-EGFRI-18 demonstrates content validity and linguistic validity, and was found conceptually equivalent to its English source, thus confirming linguistic validation. The results suggest that the Dutch FACT-EGFRI-18 can be applied to measure dAE related health related quality of life in Dutch-speaking patients undergoing EGFRI therapy. Formal validation of the Dutch FACT-EGFRI-18 is ongoing.
Independent neural coding of reward and movement by pedunculopontine tegmental nucleus neurons in freely navigating rats.

Phasic firing of dopamine (DA) neurons in the ventral tegmental area (VTA) and substantia nigra (SN) is likely to be crucial for reward processing that guides learning. One of the key structures implicated in the regulation of this DA burst firing is the pedunculopontine tegmental nucleus (PPTg), which projects to both the VTA and SN. Different literatures suggest that the PPTg serves as a sensory-gating area for DA cells or it regulates voluntary movement. This study recorded PPTg single-unit activity as rats perform a spatial navigation task to examine the potential for both reward and movement contributions. PPTg cells showed significant changes in firing relative to reward acquisition, the velocity of movement across the maze and turning behaviors of the rats. Reward, but not movement, correlates were impacted by changes in context, and neither correlate type was affected by reward manipulations (e.g. changing the expected location of a reward). This suggests that the PPTg conjunctively codes both reward and behavioral information, and that the reward information is processed in a context-dependent manner. The distinct anatomical distribution of reward and movement cells emphasizes different models of synaptic control by PPTg of DA burst firing in the VTA and SN. Relevant to both VTA and SN learning systems, however, PPTg appears to serve as a sensory gating mechanism to facilitate reinforcement learning, while at the same time provides reinforcement-based guidance of ongoing goal-directed behaviors.
Impact of Frequent Interruption on Nurses' Patient-Controlled Analgesia Programming Performance

OBJECTIVE
The purpose was to add to the body of knowledge regarding the impact of interruption on acute care nurses' cognitive workload, total task completion times, nurse frustration, and medication administration error while programming a patient-controlled analgesia (PCA) pump.


BACKGROUND
Data support that the severity of medication administration error increases with the number of interruptions, which is especially critical during the administration of high-risk medications. Bar code technology, interruption-free zones, and medication safety vests have been shown to decrease administration-related errors. However, there are few published data regarding the impact of number of interruptions on nurses' clinical performance during PCA programming.


METHOD
Nine acute care nurses completed three PCA pump programming tasks in a simulation laboratory. Programming tasks were completed under three conditions where the number of interruptions varied between two, four, and six. Outcome measures included cognitive workload (six NASA Task Load Index [NASA-TLX] subscales), total task completion time (seconds), nurse frustration (NASA-TLX Subscale 6), and PCA medication administration error (incorrect final programming).


RESULTS
Increases in the number of interruptions were associated with significant increases in total task completion time ( p = .003). We also found increases in nurses' cognitive workload, nurse frustration, and PCA pump programming errors, but these increases were not statistically significant.


APPLICATIONS
Complex technology use permeates the acute care nursing practice environment. These results add new knowledge on nurses' clinical performance during PCA pump programming and high-risk medication administration.
The promise of wearable activity sensors to define patient recovery

The recent emergence of mobile health--the use of mobile telecommunication and wireless devices to improve health outcomes, services, and research--has inspired a patient-centric approach to monitor health metrics. Sensors embedded in wearable devices are utilized to acquire greater self-knowledge by tracking basic parameters such as blood pressure, heart rate, and body temperature as well as data related to exercise, diet, and psychological state. To that end, recent studies on utilizing wireless fitness activity trackers to monitor and promote functional recovery in patients suggest that collecting up-to-date performance data could help patients regain functional independence and help hospitals determine the appropriate length of stay for a patient. This manuscript examines existing functional assessment scales, discusses the use of activity tracking sensors in evaluating functional independence, and explores the growing application of wireless technology in measuring and promoting functional recovery.
Customer relationship management : Finding value drivers

Despite significant interest from both academicians and practitioners, customer relationship management (CRM) remains a huge investment with little measured payback. Intuition suggests that increased management of customer relationships should improve business performance, but this intuition has only inconsistent empirical or real world support. To remedy this situation, this study identifies a core group of expected CRM benefits and examines their ability to increase a firm's value equity, brand equity and relationship equity which are components of customer equity. Ten propositions explore the anticipated effects of these drivers and form an agenda for future research. These propositions establish a framework for measuring CRM and supporting the link between CRM and performance. © 2006 Elsevier B.V. All rights reserved.
Health interventions for people who are homeless

Homelessness has serious implications for the health of individuals and populations. Primary health-care programmes specifically tailored to homeless individuals might be more effective than standard primary health care. Standard case management, assertive community treatment, and critical time intervention are effective models of mental health-care delivery. Housing First, with immediate provision of housing in independent units with support, improves outcomes for individuals with serious mental illnesses. Many different types of interventions, including case management, are effective in the reduction of substance misuse. Interventions that provide case management and supportive housing have the greatest effect when they target individuals who are the most intensive users of services. Medical respite programmes are an effective intervention for homeless patients leaving the hospital. Although the scientific literature provides guidance on interventions to improve the health of homeless individuals, health-care providers should also seek to address social policies and structural factors that result in homelessness.
The secondary structure of ribonuclease P RNA, the catalytic element of a ribonucleoprotein enzyme

Secondary structure models for the ribonuclease (RNAase) P RNAs of Bacillus subtilis and E. coli were derived by a phylogenetic comparative analysis of published sequences as well as four novel ones. The RNAase P RNA genes from Bacillus megaterium, Bacillus brevis, Bacillus stearothermophilus, and Pseudomonas fluorescens were cloned, sequenced, and compared with the other available sequences. Regions of pairing were identified by the occurrence of homologous complementary sequences that vary among the compared molecules. A common core of primary and secondary structure can be identified in all these RNAase P RNAs. The previously noted striking differences between the Bacillus and the enteric RNAase P RNAs arise not only from point mutations, but from the addition or deletion of structural domains. The primary and secondary structural features that are common to all of the RNAase P RNAs are likely to be the elements involved in the binding and cleavage of tRNA precursors, and in the interaction with the RNAase P protein.
Autonomous Coupling System for Goods Rail Traffic a robotic solution for marshalling yards handling hook-and-chain couplings

As globalization demands more and more flexible cargo logistics, freight trains play a big role in moving goods between production sites. Estimations show that goods rail traffic will increase and new solutions to handle wagons will be needed. Today cargo freight trains in Europe are still manually coupled via the hook-and-chain-coupling, a technology older than 100 years. A solution to allow a faster, safer and automated way is a coupling robot installed below the cargo trains at marshalling yards. This solution can be implemented gradually and with no change on rolling stock giving time to implement the long-term solution of an automatic coupling allowing ETCS Level 3 in the future.