LLukas22/scidocs huggingface dataset:
Towards the Building Information Modeling-Based Capital Project Lifecycle Management in the Luxury Yacht Industry

It will be a new approach that BIM’s capital project lifecycle management (CPLM) applied to the yacht industry. This paper explored the feasibility of applying the principles and rationales of BIM for capital project lifecycle management in luxury yacht design, engineering, fabrication, construction and operation. The paper examined the premises and backbone technology of BIM. It then evaluated leading naval engineering and shipbuilding software applications and their development trends from the functional lens of BIM. To systematically investigate a BIM-based approach for capital project lifecycle management (CPLM) in the luxury yacht industry, the paper proposed and outlined an implementation framework. A case study and a student competition use case were discussed to delineate the core constituents and processes of the proposed framework. The case of BIM was reviewed. Through the domestic custom luxury yacht design and prototyping student competition, the application of this framework in educational research is demonstrated and the initial quantitative assessment of the framework is carried out. Conclusions: a BIM-based CPLM implementation framework can help the luxury yacht industry capitalize on the global transformation to an information-centric and data-driven new business paradigm in shipbuilding with integrated design, manufacturing
A randomized, double-blind, placebo-controlled trial of desvenlafaxine succinate in adult outpatients with major depressive disorder.

OBJECTIVE
This study evaluated the efficacy and tolerability of desvenlafaxine succinate (desvenlafaxine) in the treatment of major depressive disorder (MDD).


METHOD
In this 8-week, multicenter, randomized, double-blind, placebo-controlled trial, adult outpatients (aged 18-75 years) with a primary diagnosis of MDD (DSM-IV criteria) were randomly assigned to treatment with desvenlafaxine (100-200 mg/day) or placebo. The primary outcome measure was the 17-item Hamilton Rating Scale for Depression (HAM-D(17)) score at final on-therapy evaluation. The Clinical Global Impressions-Improvement scale (CGI-I) was the key secondary measure. Other secondary measures included the Montgomery-Asberg Depression Rating Scale (MADRS), Clinical Global Impressions-Severity of Illness scale, Visual Analog Scale-Pain Intensity (VAS-PI) overall and subcomponent scores, and HAM-D(17) response and remission rates. The study was conducted from June 2003 to May 2004.


RESULTS
Of the 247 patients randomly assigned to treatment, 234 comprised the intent-to-treat population. Following titration, mean daily desvenlafaxine doses ranged from 179 to 195 mg/day. At endpoint, there were no significant differences in scores between the desvenlafaxine (N = 120) and placebo (N = 114) groups on the HAM-D(17) or CGI-I. However, the desvenlafaxine group had significantly greater improvement in MADRS scores (p = .047) and in VAS-PI overall pain (p = .008), back pain (p = .006), and arm, leg, or joint pain (p < .001) scores than the placebo group. The most common treatment-emergent adverse events (at least 10% and twice the rate of placebo) were nausea, dry mouth, constipation, anorexia, somnolence, and nervousness.


CONCLUSION
Desvenlafaxine was generally safe and well tolerated. In this study, it did not show significantly greater efficacy than placebo on the primary or key secondary efficacy endpoints, but it did demonstrate efficacy on an alternate depression scale and pain measure associated with MDD.


CLINICAL TRIALS REGISTRATION
ClinicalTrials.gov identifier NCT00063206.
Encoding subcomponents in cooperative co-evolutionary recurrent neural networks

Cooperative coevolution employs evolutionary algorithms to solve a high-dimensional search problem by decomposing it into low-dimensional subcomponents. Efficient problem decomposition methods or encoding schemes group interacting variables into separate subcomponents in order to solve them separately where possible. It is important to find out which encoding schemes efficiently group separability. This paper introduces a novel encoding scheme in cooperative coevolution for training recurrent neural networks. The method is tested on grammatical inference problems. The results show that the proposed encoding scheme achieves better performance when compared to a previous encoding scheme. & 2011 Elsevier B.V. All rights reserved.
O(sqrt(log n)) approximation algorithms for min UnCut, min 2CNF deletion, and directed cut problems

We give O(√log n)-approximation algorithms for the MIN UNCUT, MIN 2CNF DELETION, DIRECTED BALANCED SEPERATOR, and DIRECTED SPARSEST CUT problems. The previously best known algorithms give an O(log n)-approximation for MIN UNCUT [9], DIRECTED BALANCED SEPERATOR [17], DIRECTED SPARSEST CUT [17], and an O(log n log log n)-approximation for MIN 2CNF DELETION [14].We also show that the integrality gap of an SDP relaxation of the MINIMUM MULTICUT problem is Ω(log n).
Differing effects of two synthetic phonics programmes on early reading development.

BACKGROUND
Synthetic phonics is the widely accepted approach for teaching reading in English: Children are taught to sound out the letters in a word then blend these sounds together.


AIMS
We compared the impact of two synthetic phonics programmes on early reading.


SAMPLE
Children received Letters and Sounds (L&S; 7 schools) which teaches multiple letter-sound mappings or Early Reading Research (ERR; 10 schools) which teaches only the most consistent mappings plus frequent words by sight.


METHOD
We measured phonological awareness (PA) and reading from school entry to the end of the second (all schools) or third school year (4 ERR, 3 L&S schools).


RESULTS
Phonological awareness was significantly related to all reading measures for the whole sample. However, there was a closer relationship between PA and exception word reading for children receiving the L&S programme. The programmes were equally effective overall, but their impact on reading significantly interacted with school-entry PA: Children with poor PA at school entry achieved higher reading attainments under ERR (significant group difference on exception word reading at the end of the first year), whereas children with good PA performed equally well under either programme.


CONCLUSIONS
The more intensive phonics programme (L&S) heightened the association between PA and exception word reading. Although the programmes were equally effective for most children, results indicate potential benefits of ERR for children with poor PA. We suggest that phonics programmes could be simplified to teach only the most consistent mappings plus frequent words by sight.
Myocardial proinflammatory cytokine expression and left ventricular remodeling in patients with chronic mitral regurgitation.

BACKGROUND
In an animal model, stretch was shown to induce myocardial tumor necrosis factor-alpha (TNF-alpha) expression. The purposes of this study were to determine whether the left ventricular (LV) volume overload that occurs in patients with chronic mitral regurgitation (MR) can induce myocardial and systemic TNF-alpha expression and whether there is a relationship between TNF-alpha expression and LV remodeling.


METHODS AND RESULTS
Plasma TNF-alpha and its receptors were measured before mitral valve (MV) repair surgery in 26 MR patients and 23+/-12 months after MV repair surgery in 9 MR patients. Myocardial mRNA copies of TNF-alpha were determined in 11 MR and 10 donor hearts using quantitative RT-PCR. Compared with 15 control subjects, pre-MV repair plasma TNF-alpha (3.59+/-1.81 versus 2.03+/-1.02 pg/mL, P<0.005) and its receptor levels were elevated in MR patients. Myocardial TNF-alpha mRNA copies (corrected for beta-actin mRNA expression) in MR patients and donor hearts were 38.96+/-42.74x10(6) and 0.88+/-0.75x10(6), respectively (P=0.01). After MV surgery, there was a decrease in the plasma levels of TNF-alpha (2.79+/-1.14 versus 3.51+/-1.34 pg/mL, P=0.02) and its receptors. There was a correlation between myocardial TNF-alpha expression and preoperative LV end-diastolic and end-systolic volumes. Moreover, there was an inverse correlation between myocardial TNF-alpha expression and regression in LV end-diastolic (r=-0.76, P=0.007) and end-systolic (r=-0.73, P=0.01) volumes after MV surgery.


CONCLUSIONS
TNF-alpha is expressed in the myocardium and plasma of MR patients. Correction of the LV volume overload with MV surgery results in reversal of TNF-alpha expression. There is a relationship between TNF-alpha expression and parameters of LV remodeling, suggesting that TNF-alpha may play a role in the pathogenesis of the LV remodeling that occurs in MR.
Psoriasis patients' willingness to accept side-effect risks for improved treatment efficacy.

BACKGROUND
Previous studies suggest that efficacy is more important than side-effect risks to psoriasis patients. However, those studies did not consider potentially fatal risks of biologic treatments.


OBJECTIVE
To quantify the risks patients are willing to accept for improvements in psoriasis symptoms.


METHODS
Adults with a self-reported physician diagnosis of psoriasis were recruited through the National Psoriasis Foundation. Using a discrete-choice experiment, patients completed a series of nine choice questions, each including a pair of hypothetical treatments. Treatments were defined by severity of plaques, body surface area (BSA), and 10-year risks of tuberculosis, serious infection and lymphoma.


RESULTS
For complete clearance of 25% BSA with mild plaques, respondents (n = 1608) were willing to accept a 20% (95% confidence interval: 9-26%) risk of serious infection, 10% (5-15%) risk of tuberculosis and 2% (1-3%) risk of lymphoma. For complete clearance of 25% BSA with severe plaques, respondents were willing to accept a 54% (48-62%) risk of serious infection, 36% (28-49%) risk of tuberculosis and 8% (7-9%) risk of lymphoma.


LIMITATIONS
Respondents were asked to evaluate hypothetical scenarios. Actual treatment choices may differ.


CONCLUSION
Respondents were willing to accept risks above likely clinical exposures for improvements in psoriasis symptoms. Individual risk tolerances may vary.
Effectiveness of COL-1492, a nonoxynol-9 vaginal gel, on HIV-1 transmission in female sex workers: a randomised controlled trial

BACKGROUND
Nonoxynol-9 (rINN, nonoxinol-9) is an over-the-counter spermicide that has in-vitro anti-HIV-1 activity. Results of studies of its effectiveness in prevention of HIV-1 infection in women have been inconclusive. We aimed to assess effectiveness of this vaginal gel.


METHODS
We did a randomised, placebo-controlled, triple-blinded, phase 2/3 trial with COL-1492, a nonoxynol-9 vaginal gel, in 892 female sex workers in four countries: Benin, Côte d'Ivoire, South Africa, and Thailand. 449 women were randomly allocated nonoxynol-9 and 443 placebo. Primary endpoint was incident HIV-1 infection. Secondary endpoints included Neisseria gonorrhoeae and Chlamydia trachomatis infections. Analysis was by intention to treat.


FINDINGS
765 women were included in the primary analysis. HIV-1 frequency in nonoxynol-9 users was 59 (16%) of 376 compared with 45 (12%) [corrected] of 389 in placebo users (402.5 vs 435.0 woman-years; hazard ratio adjusted for centre 1.5; 95% CI 1.0-2.2; p=0.047). 239 (32%) women reported use of a mean of more than 3.5 applicators per working day, and in these women, risk of HIV-1 infection in nonoxynol-9 users was almost twice that in placebo users (hazard ratio 1.8; 95% CI 1.0-3.2). 516 (68%) women used the gel less frequently than 3.5 times a day, and in these, risk did not differ between the two treatments. No significant effect of nonoxynol-9 on N gonorrhoeae (1.2; 0.9-1.6) or C trachomatis (1.2; 0.8-1.6) infections was reported.


INTERPRETATION
This study did not show a protective effect of COL-1492 on HIV-1 transmission in high-risk women. Multiple use of nonoxynol-9 could cause toxic effects enhancing HIV-1 infection. This drug can no longer be deemed a potential HIV-1-prevention method. Assessment of other microbicides should continue.
Effects of relaxation therapy on psychologic distress and symptom status in older Chinese patients with heart failure.

BACKGROUND
Previous studies demonstrated the effects of progressive muscle relaxation training (PMRT) on improvements in the health outcomes of cardiac patients. This study examined the effects of PMRT on the psychologic status and symptoms of older Chinese patients with heart failure.


METHODS
In a longitudinal, randomized, and controlled study, 59 patients were allocated to receive a PMRT program and 62 were provided with the attention placebo. The PMRT program included two PMRT sessions, one revision workshop, twice-daily PMRT home practices, and a biweekly telephone follow-up call. The attention placebo included a regular telephone call at a schedule similar to that made by the interventionist of the PMRT program with the intervention group. Main outcome measures, including psychologic distress, dyspnea, and fatigue, were taken at baseline, the 8th week, and the 14th week.


RESULTS
A medium effect on psychologic distress in favor of the PMRT program was detected. Patients practicing PMRT however only demonstrated a nonsignificant trend of greater improvement in symptom status.


CONCLUSION
Progressive muscle relaxation training seems to be useful as an adjunctive nonpharmacologic treatment modality in the management of heart failure.
Consumer Credit Scoring: Do Situational Circumstances Matter?

Although credit history scoring offers benefits to lenders and borrowers, failure to consider situational circumstances raises important statistical issues that may affect the ability of scoring systems to accurately quantify an individual’s credit risk. Evidence from a national sample of credit reporting agency records suggests that failure to consider measures of local economic circumstances and individual trigger events when developing credit history scores can diminish the potential effectiveness of such models. There are practical difficulties, however, associated with developing scoring models that incorporate situational data, arising largely because of inherent limitations of the credit reporting agency databases used to build scoring models. . JEL Code: G2
The scientific works of Rainer Kemp (1949-2004)

This short note presents a summary of the scientific contributions of Rainer Kemp (1949-2004) in the area of discrete mathematics, combinatorial enumeration, and analysis of algorithms. A complete bibliography of Kemp's publications is included.
Accumulation of heavy metals in leaf vegetables from agricultural soils and associated potential health risks in the Pearl River Delta, South China

This study investigated the extent of heavy metal accumulation in leaf vegetables and associated potential health risks in agricultural areas of the Pearl River Delta (PRD), South China. Total concentrations of mercury (Hg), cadmium (Cd), lead (Pb), chromium (Cr) and arsenic (As) were determined in 92 pairs of soil and leaf vegetable (flowering Chinese cabbage, lettuce, pakchoi, Chinese cabbage, loose-leaf lettuce, and Chinese leaf mustard) samples collected from seven agricultural areas (cities). The bioconcentration factors (BCF) of heavy metals from soil to vegetables were estimated, and the potential health risks of heavy metal exposure to the PRD residents through consumption of local leaf vegetables were assessed. Results showed that among the six leaf vegetables, pakchoi had the lowest capacity for heavy metal enrichment, whereas among the five heavy metals, Cd had the highest capacity for transferring from soil into vegetables, with BCF values 30-fold those of Hg and 50-fold those of Cr, Pb and As. Sewage irrigation and fertilization were likely the main sources of heavy metals accumulated in leaf vegetables grown in agricultural areas of the PRD region. Different from previous findings, soil pH had no clear effect on metal accumulation in leaf vegetables. Despite a certain degree of metal enrichment from soil to leaf vegetables, the PRD residents were not exposed to significant health risks associated with consumption of local leaf vegetables. Nevertheless, more attention should be paid to children due to their sensitivity to metal pollutants.
The spectrum of giant cell arteritis and polymyalgia rheumatica: revisiting the concept of the disease.

GCA and PMR are conditions of older persons that frequently overlap. The traditional concept of GCA has focused on cranial symptoms such as headache and visual disturbance, but extra-cranial manifestations such as constitutional symptoms, polymyalgia and limb claudication have also long been recognized. These symptoms may coincide with cranial GCA, occur as an independent clinical subset [large-vessel (LV) GCA] or overlap with PMR. Imaging studies have demonstrated that up to one-third of patients with PMR have subclinical LV inflammation at disease outset. The implication of this finding for PMR management is unclear. Pathophysiological studies have emphasized the pivotal role of dendritic cells (DCs) and T cells in the pathogenesis of GCA, and the activation of certain pattern recognition receptors on DCs may determine the clinical subset of GCA. In patients with only PMR clinically, it is conceivable that transmural arterial inflammation has either not yet started or is prevented by unexplored regulatory pathways. This concept is supported by vasculitis of peri-adventitial small-vessels and activated DCs in the adventitia of temporal arteries, in the absence of media-infiltrating T cells. This review examines the clinical and pathophysiological spectrum of GCA and its subsets with PMR, the role of newer imaging techniques for GCA diagnosis and the management of these diseases.
Morphological and Syntactic Case in Statistical Dependency Parsing

Most morphologically rich languages with free word order use case systems to mark the grammatical function of nominal elements, especially for the core argument functions of a verb. The standard pipeline approach in syntactic dependency parsing assumes a complete disambiguation of morphological (case) information prior to automatic syntactic analysis. Parsing experiments on Czech, German, and Hungarian show that this approach is susceptible to propagating morphological annotation errors when parsing languages displaying syncretism in their morphological case paradigms. We develop a different architecture where we use case as a possibly underspecified filtering device restricting the options for syntactic analysis. Carefully designed morpho-syntactic constraints can delimit the search space of a statistical dependency parser and exclude solutions that would violate the restrictions overtly marked in the morphology of the words in a given sentence. The constrained system outperforms a state-of-the-art data-driven pipeline architecture, as we show experimentally, and, in addition, the parser output comes with guarantees about local and global morpho-syntactic wellformedness, which can be useful for downstream applications.
Effects of solvent type on phenolics and flavonoids content and antioxidant activities in two varieties of young ginger (Zingiber officinale Roscoe) extracts

The extractive capability of phenolic components from herb material is considerably depended on the type of solvent. In our research three kinds of solvents (methanol, acetone and chloroform) extracts from different parts (leaves, stems and rhizomes) of two Malaysian young ginger varieties (Halia Bara and Halia Bentong) were used to examine the effects of extraction solvent on total phenolics (TP), total flavonoids (TF), quercetin, catechin and rutin content and antioxidant activity [1,1-diphenyl-2-picrylhydrazyl (DPPH) assay]. Results showed that extraction solvent had significant effects on TP, TF, quercetin, catechin and rutin content and antioxidant activity. The highest content of TP, TF and DPPH scavenging activities were found in methanol extracts. Additionally, High performance liqouid chromatography results shown that methanol had the highest extraction capacity for quercetin, rutin and catechin. Between varieties Halia Bara had high content of TP, TF and antioxidant activities to compare with Halia Bentong. Accumulation and partitioning of TP and TF in both varieties were: leaves > rhizomes > stems in all the three solvent extracts. However, according to the results extraction yield of phenolic compounds is greatly depending on the solvent polarity. With increased in solvent polarity from chloroform to methanol, amount of phenolic compounds and antioxidant activities increased in both varieties. Thus, for routine screening of young ginger varieties with higher antioxidant activity, methanol was recommended to extract phenolic compounds from young ginger.
Effect of cigarette smoking on intraocular pressure.

postoperative corneal sensitivity; however, no signifi­ cant changes were detected in the intergroup compar­ isons. (4) Group B had an 8.2% reduction in ECC, significantly higher than in the rest of the groups (Group A1: 4.8%; Group A2: 5.0%). (5) Endothelial cell loss showed linear correlation with CDE (Group B: r Z 0.47; Group A2: r Z 0.81; both P ! .01) (Figure 1). (6) Group A2 patients had significantly worse scores on the subjective discomfort index. The clinical significance of our study is that in energy-demanding cataracts, the combination of dispersive and cohesive OVDs seems to protect the endothelial cells more efficiently than the cohesiveonly OVD (Visthesia). That is, for the same CDE, more endothelial cells were lost in the cohesive-only OVD patients. Moreover, the endothelial loss pattern in these patients was more random than the in the dispersive–cohesive OVD (Duovisc) patients. How­ ever, although statistically significant, the increased endothelial loss in the cohesive-only OVD patients did not interfere with postoperative visual acuity or corneal thickness. On the other hand, the subjective discomfort feeling was significantly more pronounced in the dispersive–cohesive OVD patients; therefore additional intracameral anesthesia is considered to be necessary. The intracameral anesthesia we used in our study provided anesthesia comparable to that of the cohesive-only OVD, with no evident impact on endothelial cells. In summary, we consider that Visthesia and Duovisc offer comparable surgical outcomes in stage 3 cataract extraction surgery using torsional intelligent phaco technology. Despite the fact that the international liter­ ature provides conflicting comparative outcomes regarding the efficacy of the several commercially available OVDs, our results suggest that Duovisc provides an additional significant protective effect on endothelial cells that should be taken into consider­ ation, especially in cases with a low preoperative ECC. REFERENCES