LLukas22/scidocs huggingface dataset:
Differential response to antidepressants in women with premenstrual syndrome/premenstrual dysphoric disorder: a randomized controlled trial.

BACKGROUND
Studies show that selective serotonin reuptake inhibitors are effective for severe premenstrual syndrome and premenstrual dysphoric disorder. This study compares the efficacy of a selective serotonin reuptake inhibitor with that of a tricyclic antidepressant to determine whether efficacy for premenstrual syndrome/premenstrual dysphoric disorder is a general or more serotonergic effect of antidepressants.


METHODS
After 3 screening months, 189 subjects were randomized to sertraline hydrochloride, desipramine hydrochloride, or placebo for 3 months of double-blind treatment. The flexible dosage range was 50 to 150 mg/d. The outcome measures included the Penn Daily Symptom Report (DSR), the Hamilton Depression Rating Scale, the Clinical Global Impressions-Severity Scale, the Quality of Life Scale, and Patient Global Ratings of Functioning and Improvement. Analyses included all subjects with treatment data, with the last observation carried forward.


RESULTS
Sertraline was significantly more effective than placebo or desipramine; desipramine was not better than placebo (F2,163 = 12.47, P<.001). All DSR factors were more improved with sertraline compared with desipramine and placebo; the factors for mood (P<.001) and pain (P = .05) were significant, and the results of all outcome measures were consistent. A history of depression, postmenstrual symptom levels, and other diagnostic variables added individually as covariates did not alter the treatment results. At end point analysis, DSR symptoms had decreased by more than 50% in 40 subjects (65%) in the sertraline group, 18 subjects (36%) in the desipramine group, and 16 subjects (29%) in the placebo group (P<.001).


CONCLUSIONS
The comparison of 2 classes of antidepressants strongly favored the serotonergic drug, which effectively reduced symptoms and improved functioning and was well tolerated by women with severe premenstrual syndrome. A history of depression did not alter the treatment results.
Femtosecond x rays from laser-plasma accelerators

Relativistic interaction of short-pulse lasers with underdense plasmas has recently led to the emergence of a novel generation of femtosecond x-ray sources. Based on radiation from electrons accelerated in plasma, these sources have the common properties to be compact and to deliver collimated, incoherent and femtosecond radiation. In this article we review, within a unified formalism, the betatron radiation of trapped and accelerated electrons in the so-called bubble regime, the synchrotron radiation of laseraccelerated electrons in usual meter-scale undulators, the nonlinear Thomson scattering from relativistic electrons oscillating in an intense laser field, and the Thomson backscattered radiation of a laser beam by laser-accelerated electrons. The underlying physics is presented using ideal models, the relevant parameters are defined, and analytical expressions providing the features of the sources are given. Numerical simulations and a summary of recent experimental results on the different mechanisms are also presented. Each section ends with the foreseen development of each scheme. Finally, one of the most promising applications of laser-plasma accelerators is discussed: the realization of a compact free-electron laser in the x-ray range of the spectrum. In the conclusion, the relevant parameters characterizing each sources are summarized. Considering typical laser-plasma interaction parameters obtained with currently available lasers, examples of the source features are given. The sources are then compared to each other in order to define their field of applications.
Energy drinks and their component modulate attention, memory, and antioxidant defences in rats.

PURPOSE
This study aimed to evaluate the effects of the subchronic consumption of energy drinks and their constituents (caffeine and taurine) in male Wistar rats using behavioural and oxidative measures.


METHODS
Energy drinks (ED 5, 7.5, and 10 mL/kg) or their constituents, caffeine (3.2 mg/kg) and taurine (40 mg/kg), either separately or in combination, were administered orally to animals for 28 days. Attention was measured though the ox-maze apparatus and the object recognition memory test. Following behavioural analyses, markers of oxidative stress, including SOD, CAT, GPx, thiol content, and free radicals, were measured in the prefrontal cortex, hippocampus, and striatum.


RESULTS
The latency time to find the first reward was lower in animals that received caffeine, taurine, or a combination of both (P = 0.003; ANOVA/Bonferroni). In addition, these animals took less time to complete the ox-maze task (P = 0.0001; ANOVA/Bonferroni), and had better short-term memory (P < 0.01, Kruskal-Wallis). The ED 10 group showed improvement in the attention task, but did not differ on other measures. In addition, there was an imbalance in enzymatic markers of oxidative stress in the prefrontal cortex, the hippocampus, and the striatum. In the group that received both caffeine and taurine, there was a significant increase in the production of free radicals in the prefrontal cortex and in the hippocampus (P < 0.0001; ANOVA/Bonferroni).


CONCLUSIONS
Exposure to a combination of caffeine and taurine improved memory and attention, and led to an imbalance in the antioxidant defence system. These results differed from those of the group that was exposed to the energy drink. This might be related to other components contained in the energy drink, such as vitamins and minerals, which may have altered the ability of caffeine and taurine to modulate memory and attention.
The Mental Activity and eXercise (MAX) trial: a randomized controlled trial to enhance cognitive function in older adults.

IMPORTANCE
The prevalence of cognitive impairment and dementia are projected to rise dramatically during the next 40 years, and strategies for maintaining cognitive function with age are critically needed. Physical or mental activity alone result in relatively small, domain-specific improvements in cognitive function in older adults; combined interventions may have more global effects.


OBJECTIVE
To examine the combined effects of physical plus mental activity on cognitive function in older adults.


DESIGN
Randomized controlled trial with a factorial design.


SETTING
San Francisco, California.


PARTICIPANTS
A total of 126 inactive, community-residing older adults with cognitive complaints.


INTERVENTIONS
All participants engaged in home-based mental activity (1 h/d, 3 d/wk) plus class-based physical activity (1 h/d, 3 d/wk) for 12 weeks and were randomized to either mental activity intervention (MA-I; intensive computer) or mental activity control (MA-C; educational DVDs) plus exercise intervention (EX-I; aerobic) or exercise control (EX-C; stretching and toning); a 2 × 2 factorial design was used so that there were 4 groups: MA-I/EX-I, MA-I/EX-C, MA-C/EX-1, and MA-C/EX-C.


MAIN OUTCOME MEASURES
Global cognitive change based on a comprehensive neuropsychological test battery.


RESULTS
Participants had a mean age of 73.4 years; 62.7% were women, and 34.9% were Hispanic or nonwhite. There were no significant differences between the groups at baseline. Global cognitive scores improved significantly over time (mean, 0.16 SD; P < .001) but did not differ between groups in the comparison between MA-I and MA-C (ignoring exercise, P = .17), the comparison between EX-I and EX-C (ignoring mental activity, P = .74), or across all 4 randomization groups (P = .26).


CONCLUSIONS AND RELEVANCE
In inactive older adults with cognitive complaints, 12 weeks of physical plus mental activity was associated with significant improvements in global cognitive function with no evidence of difference between intervention and active control groups. These findings may reflect practice effects or may suggest that the amount of activity is more important than the type in this subject population.


TRIAL REGISTRATION
clinicaltrials.gov Identifier: NCT00522899.
Assessing the Usefulness of a Cartographic Curiosity: The 1673 Map of a Sugar Island

Abstract During the colonial period, maps of the New World were important sources of information to Europeans, providing graphic depictions of the resources and inhabitants of new lands as well as of the progress being made by colonists. Today these historic maps are intriguing to scholars, yet they are rarely used to the fullest extent possible as sources of historical data. The 1673 map of the eastern Caribbean island of Montserrat is used to demonstrate how cartometry, documentary research, and field study can be used to reap valuable information from a supposed unreliable source. After I corrected the map for spatial distortion, I checked the data it contained against contemporary documents and the results of archaeological and geographical field research. My conclusion is the map is so accurate that it may serve as a freeze frame of seventeenth-century colonial agency.
N-Acetyltransferase 2 Genotype-Related Efficacy of Sulfasalazine in Patients with Rheumatoid Arthritis

Purpose. For the individual optimization of drug therapy with sulfasalazine (SASP), we studied the influence of the N-acetyltransferase 2 (NAT2) genotype on the pharmacokinetics, efficacy, and incidence of adverse reactions of SASP in patients. Methods. Ninety-six rheumatoid arthritis (RA) patients were treated or had been treated with 0.5 and/or 1.0 g/day of SASP. The wild-type allele (NAT2*4) and three variant alleles (NAT2*5B, *6A, and *7B) of NAT2 were determined by the polymerase chain reaction-restriction fragment length polymorphism method. Plasma concentrations of SASP and its two metabolites, sulfapyridine (SP) and N-acetylsulfapyridine (AcSP), were estimated by HPLC. Therapeutic efficacy and incidence of adverse reactions were also monitored as recommended by the American College of Rheumatology. Results. Patients were classified into three groups by NAT2 genotyping: Rapid Type (homozygote for NAT2*4), Intermediate Type (heterozygote for NAT2*4 and variant alleles), and Slow Type (homozygote for variant alleles). There was no clear difference in the genotype frequencies between RA patients and healthy subjects. NAT2 genotypes significantly affected both the plasma concentration ratios of SP to AcSP (SP/AcSP) and the efficacy of SASP (p < 0.05). Adverse reactions to SASP were found in 26 (27.1%) out of 96 patients, and there was no difference among the three genotype groups. Conclusions. NAT2 gene polymorphism is related to the plasma SP/AcSP ratio and the efficacy of SASP.
A Basic Extended Simple Type Theory

This paper presents an extended version of Church’s simple type theory called Basic Extended Simple Type Theory (bestt). By adding type variables and support for reasoning with tuples, lists, and sets to simple type theory, it is intended to be a practical logic for formalized mathematics.
Evaluation for airway obstruction in adult patients with stable ischemic heart disease

BACKGROUND
Ischemic heart disease (IHD) and chronic airway disease (COPD and Asthma) are major epidemics accounting for significant mortality and morbidity. The combination presents many diagnostic challenges. Clinical symptoms and signs frequently overlap. There is a need for airway evaluation in these patients to plan appropriate management.


METHODS
Consecutive stable IHD patients attending the cardiology OPD in a tertiary care centre were interviewed for collecting basic demographic information, brief medical, occupational, personal history and risk factors for coronary artery disease and airway disease, modified medical research centre (MMRC) grade for dyspnea, quality of life-St. George respiratory questionnaire (SGRQ), spirometry and six-min walk tests. Patients with chronic airway obstruction were treated as per guidelines and were followed up at 3rd month with spirometry, six-minute walk test and SGRQ.


RESULTS
One hundred fourteen consecutive patients with stable cardiac disease were included (Males-88, Females-26). Mean age was 58.89±12.24years, 53.50% were smokers, 31.56% were alcoholics, 40.35% diabetics, 47.36% hypertensive. Twenty five patients had airway obstruction on spirometry (COPD-13 and Asthma-12) and none were on treatment. Thirty-one patients had cough and 48 patients had dyspnea. Patients with abnormal spirometry had higher symptoms, lower exercise tolerance and quality of life. Treatment with appropriate respiratory medications resulted in increase in lung function, quality of life and exercise tolerance at 3rd month.


CONCLUSION
Chronic respiratory disease in patients with stable IHD is frequent but often missed due to overlap of symptoms. Spirometry is a simple tool to recognize the underlying pulmonary condition and patients respond favorably with appropriate treatment.
Polarized Tamm plasmon laser

Plasmonic Tamm states are interface modes formed at the boundary between a distributed Bragg mirror and a metallic layer. Their optical properties lie in between surface plasmons and microcavity photonic modes. In particular, the losses are reduced compared to a conventional plasmon. We will describe some features of semiconductor quantum wells coupled to extended Tamm modes, like strong coupling with the excitons and lasing. The main advantage of the Tamm modes lies in the easy confinement of the mode which can be obtained only by structuring the metallic part of the structure.
CannyLines: A parameter-free line segment detector

In this paper, we present a robust line segment detection algorithm to efficiently detect the line segments from an input image. Firstly a parameter-free Canny operator, named as CannyPF, is proposed to robustly extract the edge map from an input image by adaptively setting the low and high thresholds for the traditional Canny operator. Secondly, both efficient edge linking and splitting techniques are proposed to collect collinear point clusters directly from the edge map, which are used to fit the initial line segments based on the least-square fitting method. Thirdly, longer and more complete line segments are produced via efficient extending and merging. Finally, all the detected line segments are validated due to the Helmholtz principle [1, 2] in which both the gradient orientation and magnitude information are considered. Experimental results on a set of representative images illustrate that our proposed line segment detector, named as CannyLines, can extract more meaningful line segments than two popularly used line segment detectors, LSD [3] and ED-Lines [4], especially on the man-made scenes.
Social entrepreneurship : Creating new business models to serve the poor

0007-6813/$ see front matter D 200 doi:10.1016/j.bushor.2004.11.006 * Corresponding author. E-mail addresses: cseelos@sscg.org jmair@iese.edu (J. Mair).
Research of STATCOM Impact on Wind Farm LVRT and Protection

Because of the wind turbine which possesses low voltage ride through (LVRT) capability can keep on working during the system fault, greatly reduce the adverse effects of power grid and ensure the relay protection reliability. However, the asynchronous wind turbine which widely used in home and abroad doesn’t have enough LVRT capability. So this paper proposes a method to enhance the LVRT capability of fixed speed induction generator (FSIG) based on wind farm using static synchronous compensator (STATCOM). And this paper establishes the simulation model of asynchronous wind generator wind farm and STATCOM in Matlab/Simulink software; the research results show that the STATCOM device can improve asynchronous wind farm LVRT capability. Then analysis the asynchronous wind generator which possess LVRT ability characteristics and the time of the action protection relations.According to the current wind farm system protection configuration, studying the asynchronous wind farm which with STATCOM device effect on protection configuration of system and the existing problems. At last, putting forward some reasonable measures of improving LVRT cooperate with relay protection characteristics and minimizing probability of wind power units take off the grid.
Identifying the semantic orientation of terms using S-HAL for sentiment analysis

0950-7051/$ see front matter 2012 Elsevier B.V. A http://dx.doi.org/10.1016/j.knosys.2012.04.011 ⇑ Corresponding author at: MOE Key Laboratory Network Security, Xi’an Jiaotong University, Xi’an 71 82667964. E-mail addresses: txu@mail.xjtu.edu.cn (T. Xu (Q. Peng). Sentiment analysis continues to be a most important research problem due to its abundant applications. Identifying the semantic orientation of subjective terms (words or phrases) is a fundamental task for sentiment analysis. In this paper, we propose a new method for identifying the semantic orientation of subjective terms to perform sentiment analysis. The method takes a classification approach that is based on a novel semantic orientation representation model called S-HAL (Sentiment Hyperspace Analogue to Language). S-HAL basically produces a set of weighted features based on surrounding words, and characterizes the semantic orientation information of words via a specific feature space. Because the method incorporates the idea underlying HAL and the hypothesis verified by the method of semantic orientation inference from pointwise mutual information (SO-PMI), it can quickly and accurately identify the semantic orientation of terms without the use of an Internet search engine. The results of an empirical evaluation show that our method outperforms other known methods. 2012 Elsevier B.V. All rights reserved.
A wireless sensor network for structural health monitoring: performance and experience

While sensor network research has made significant strides in the past few years, the literature has relatively few examples of papers that have evaluated and validated a complete experimental system. In this paper, we discuss our deployment experiences and evaluate the performance of a multi-hop wireless data acquisition system (called Wisden) for structural health monitoring (SHM) on a large seismic test structure used by civil engineers. Our experiments indicate that, with the latest sensor network hardware, Wisden can reliably deliver time-synchronized tri-axial structural vibration data reliably across multiple hops with low latencies for sampling rates up to 200 Hz. This performance was achieved by iteratively refining the system design using a series of test deployments. Our experiences suggested the need for careful onset detection in order to preserve the fidelity of the structure's frequency response. Furthermore, the high damping characteristics of large structures motivated an exploration of the processing, sampling, and communication limits of current platforms.
Effects of ionized waterfall aerosol on pediatric allergic asthma.

OBJECTIVE
Ionized water aerosols have been suggested to exert beneficial health effects on pediatric allergic asthma. Their effect was evaluated in a randomized controlled clinical trial as part of a summer asthma camp.


METHODS
Asthmatic allergic children (n = 54) spent 3 weeks in an alpine asthma camp; half of the group was exposed to water aerosol of an alpine waterfall for 1 hour per day, whereas the other half spent the same time at a "control site". Immunological analysis, lung function testing, and fractional exhaled nitric oxide (FeNO) testing were performed during the stay, and sustaining effects were evaluated 2 months later. Symptom score testing was done over a period of 140 days.


RESULTS
The water aerosol group showed a significant improvement in all lung function parameters, whereas only the peak expiratory flow improved in the control group. All patients showed a significant improvement in symptom score and a significant decrease in FeNO after the camp. Only the water aerosol group exhibited a long-lasting effect on asthma symptoms, lung function, and inflammation in the follow-up examination. Induction of interleukin (IL)-10 and regulatory T (Treg) cells was measured in both groups, with a pronounced increase in the water aerosol group. IL-13 was significantly decreased in both groups, whereas IL-5 and eosinophil cationic protein were decreased only in the water aerosol group.


CONCLUSIONS
Our findings confirm the induction of Treg cells and reduction in inflammation by climate therapy. They indicate a synergistic effect of water aerosols resulting in a long-lasting beneficial effect on asthma symptoms, lung function, and airway inflammation.
The relationship between coping strategies, quality of life, and mood in patients with incurable cancer.

BACKGROUND
Patients with incurable cancer face many physical and emotional stressors, yet little is known about their coping strategies or the relationship between their coping strategies, quality of life (QOL), and mood.


METHODS
As part of a randomized trial of palliative care, this study assessed baseline QOL (Functional Assessment of Cancer Therapy-General), mood (Hospital Anxiety and Depression Scale), and coping (Brief COPE) in patients within 8 weeks of a diagnosis of incurable lung or gastrointestinal cancer and before randomization. To examine associations between coping strategies, QOL, and mood, we used linear regression, adjusting for patients' age, sex, marital status, and cancer type.


RESULTS
There were 350 participants (mean age, 64.9 years), and the majority were male (54.0%), were married (70.0%), and had lung cancer (54.6%). Most reported high utilization of emotional support coping (77.0%), whereas fewer reported high utilization of acceptance (44.8%), self-blame (37.9%), and denial (28.2%). Emotional support (QOL: β = 2.65, P < .01; depression: β = -0.56, P = .02) and acceptance (QOL: β = 1.55, P < .01; depression: β = -0.37, P = .01; anxiety: β = -0.34, P = .02) correlated with better QOL and mood. Denial (QOL: β = -1.97, P < .01; depression: β = 0.36, P = .01; anxiety: β = 0.61, P < .01) and self-blame (QOL: β = -2.31, P < .01; depression: β = 0.58, P < .01; anxiety: β = 0.66, P < .01) correlated with worse QOL and mood.


CONCLUSIONS
Patients with newly diagnosed, incurable cancer use a variety of coping strategies. The use of emotional support and acceptance coping strategies correlated with better QOL and mood, whereas the use of denial and self-blame negatively correlated with these outcomes. Interventions to improve patients' QOL and mood should seek to cultivate the use of adaptive coping strategies. Cancer 2016;122:2110-6. © 2016 American Cancer Society.
Survey and evaluation of food recommendation systems and techniques

Recommending proper food is of paramount importance for person's sound health. It is also useful in revenue generation in restaurants by recommending varied choices of food or recommending restaurants depending on the type of food to customers. In this paper, we survey the existing food recommendation engines and compare the different recommendation algorithms - Content based filtering, collaborative filtering, hybrid techniques etc. Further, we would see the challenges and limitations of each technique.