LLukas22/scidocs huggingface dataset:
Familial Pelger-Huet Anomaly.

Pelger-Huet anomaly is usually autosomal dominant, although it is likely that new mutations are common. This condition is characterized by granulocytes that are either bilobed or completely unsegmented. Here is a report of a 46 year old Indian lady who presented with fever to the hospital and on evaluation, her peripheral blood smear showed extreme hypolobation of granulocytes. Along with normal appearing neutrophils there were many neutrophils with bilobed and single monolobated nuclei which accounted for 82 % of the neutrophils. After identifying these neutrophilic abnormalities which were suggestive of Pelgeroid changes, the other family members were also screened and were found to be having similar morphologic abnormalities in granulocytes. As these changes were evident in granulocytic leucocytes of the patient as well as her mother, both her sisters and her son, with exception of her brother, the diagnosis of familial Pelger-Huet Anomaly was considered in this case.
Probiotics for prevention of necrotizing enterocolitis in preterm infants.

BACKGROUND
Necrotizing enterocolitis (NEC) and nosocomial sepsis are associated with increased morbidity and mortality in preterm infants. Through prevention of bacterial migration across the mucosa, competitive exclusion of pathogenic bacteria, and enhancing the immune responses of the host, prophylactic enteral probiotics (live microbial supplements) may play a role in reducing NEC and associated morbidity.


OBJECTIVES
To compare the efficacy and safety of prophylactic enteral probiotics administration versus placebo or no treatment in the prevention of severe NEC and/or sepsis in preterm infants.


SEARCH STRATEGY
For this update, searches were made of MEDLINE (1966 to October 2010), EMBASE (1980 to October 2010), the Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library, Issue 2, 2010), and abstracts of annual meetings of the Society for Pediatric Research (1995 to 2010).


SELECTION CRITERIA
Only randomized or quasi-randomized controlled trials that enrolled preterm infants < 37 weeks gestational age and/or < 2500 g birth weight were considered. Trials were included if they involved enteral administration of any live microbial supplement (probiotics) and measured at least one prespecified clinical outcome.


DATA COLLECTION AND ANALYSIS
Standard methods of the Cochrane Collaboration and its Neonatal Group were used to assess the methodologic quality of the trials, data collection and analysis.


MAIN RESULTS
Sixteen eligible trials randomizing 2842 infants were included. Included trials were highly variable with regard to enrollment criteria (i.e. birth weight and gestational age), baseline risk of NEC in the control groups, timing, dose, formulation of the probiotics, and feeding regimens. Data regarding extremely low birth weight infants (ELBW) could not be extrapolated. In a meta-analysis of trial data, enteral probiotics supplementation significantly reduced the incidence of severe NEC (stage II or more) (typical RR 0.35, 95% CI 0.24 to 0.52) and mortality (typical RR 0.40, 95% CI 0.27 to 0.60). There was no evidence of significant reduction of nosocomial sepsis (typical RR 0.90, 95% CI 0.76 to 1.07). The included trials reported no systemic infection with the probiotics supplemental organism. The statistical test of heterogeneity for NEC, mortality and sepsis was insignificant.


AUTHORS' CONCLUSIONS
Enteral supplementation of probiotics prevents severe NEC and all cause mortality in preterm infants. Our updated review of available evidence supports a change in practice. More studies are needed to assess efficacy in ELBW infants and assess the most effective formulation and dose to be utilized.
An Empirical Investigation of Net-Enabled Business Value

acknowledges support by the National Science Foundation CAREER award under contract number IIS-9875746. The authors are grateful to the senior editor, associate editor and three anonymous reviewers for constructive critique and suggestions for improvements. Austin. His publications have appeared in several top tier journals such as American Economic Review, ABSTRACT Many traditional organizations have undertaken major initiatives to leverage the Internet to transform how they coordinate value activities with customers, suppliers and other business partners with the objective of improving firm performance. This paper addresses processes through which business value is created through such Internet-enabled value chain activities. Relying on the resource-based view (RBV) of the firm, we propose a model positing that a firm's abilities to coordinate and exploit firm resources – processes, IT and readiness of customers and suppliers – create online informational capabilities – a higher order resource – which then leads to improved operational and financial performance. The outcome of a firm's online informational capabilities is reflected in superior operational performance through customer and supplier-side digitization efforts, which reflect the extent to which transactions and external interactions occur electronically. We also hypothesize that increased customer and supplier-side digitization leads to better financial performance. The model is tested with data from over 1000 firms in manufacturing, retail and wholesale sectors. The analysis suggests that while most firms are lagging in their supplier-side initiatives relative to the customer-side, supplier-side digitization has a strong positive impact on customer-side digitization, which, in turn, leads to better financial performance. Further, both customer and supplier readiness to engage in digital interactions are shown to be as important as a firm's internal digitization initiatives, implying that a firm's transformation-related decisions should include its customers' and suppliers' resources and incentives.
Factors associated with discussion of sexual activity and contraception in women with HIV.

OBJECTIVES
Contraceptive use is important for reproductive-aged women living with HIV to plan and optimise safety of pregnancies. Clinicians play a vital role in counselling patients about contraception and safe sexual activity. This study aimed to determine the frequency and predictors of discussions regarding sexual activity and contraceptive use.


METHODS
Retrospective clinical study of all reproductive-aged women (n=128) treated for HIV between 2010 and 2012 at two metropolitan hospitals. Evidence of discussion between treating doctors and patients regarding sexual activity and contraception and variables including patient age, gender of doctor, time since HIV diagnosis, previous pregnancy, country of birth and antiretroviral regimen were obtained from medical records.


RESULTS
Sexual activity status was documented for 54% of the women and discussion regarding contraception was recorded for less than one-third of the study participants. Contraceptive use was not recorded in 63% of the medical records. In the study cohort 27% of the women used contraception, 10% did not use contraception, and when a discussion regarding sexual activity was documented, contraception was 3.7 times more likely to also be discussed (p=0.04). Excluding women who were pregnant, women who were documented as using contraception were 1.8 times as likely to have had a discussion about contraception documented (p=0.05). After adjustment for other factors, previous pregnancy, gender of doctor and age of patient were not associated with discussions regarding sexual activity or contraception.


CONCLUSIONS
Discussions regarding sexual activity and contraception between HIV-infected women of reproductive age and their clinicians were inconsistent and suboptimal. Mechanisms to facilitate regular discussion about sexual activity and contraception between clinicians and women with HIV warrant further investigation.
Paleomagnetism of the Late Cretaceous ignimbrite from the Okhotsk-Chukotka Volcanic Belt, Kolyma-Omolon Composite Terrane: Tectonic implications

Abstract New Late Cretaceous paleomagnetic results from the Okhotsk-Chukotka Volcanic Belt in the Kolyma-Omolon Composite Terrane yield stable and consistent remanent directions. The Late Cretaceous (86–81 Ma) ignimbrites from the Kholchan and Ola suites were sampled at 19 sites in the Magadan area (60.4° N, 151.0° E). We isolated the characteristic paleomagnetic directions from 16 sampled sites using an alternating field demagnetization procedure. The primary nature of these directions is ascertained by dual polarities and positive fold tests. A tilt-corrected mean direction ( D  = 42.8°, I  = 84.7°, k  = 46.0, α 95  = 10.0°) yields a paleomagnetic pole of 66.7° N, 168.5° E ( A 95  = 18.8°) which appears almost identical to the 90–67 Ma pole reported from the Lake El’gygytgyn area of the Okhotsk-Chukotka Volcanic Belt (Chukotka Terrane). This consistency suggests that the Kolyma-Omolon Composite Terrane and Chukotka Terrane has acted as a single tectonic unit since 80 Ma without any significant internal deformation. Accordingly, we calculate a combined 80 Ma characteristic paleomagnetic pole (Long. = 164.7° E, Lat. = 68.0°, A 95  = 10.9°, N  = 12) for the Kolyma-Omolon-Chukotka Block which falls 16.5–17.5° south of the same age poles from Europe and East Asia. We ascribe this discrepancy in pole positions to tectonic activity in the area and infer a southward displacement of 1640 ± 1380 km for the Kolyma-Omolon-Chukotka Block with respect to the North American and Eurasian blocks since 80 Ma; more than 260 km of it is attributed to tectonic displacement in the Arctic Ocean due to the opening of the Canadian Basin.
Garlic powder and plasma lipids and lipoproteins: a multicenter, randomized, placebo-controlled trial.

BACKGROUND
Garlic powder tablets have been reported to lower serum cholesterol levels. There is widespread belief among the general public that garlic powder tablets aid in controlling cholesterol levels. However, much of the prior data demonstrating the cholesterol-lowering effect of garlic tablets involved studies that were inadequately controlled.


OBJECTIVE
To determine the lipid-lowering effect of garlic powder tablets in patients with hypercholesterolemia.


METHODS
This was a randomized, double-blind, placebo-controlled, 12-week, parallel treatment study carried out in 2 outpatient lipid clinics. Entry into the study after 8 weeks of diet stabilization required a mean low-density lipoprotein cholesterol level on 2 visits of 4.1 mmol/L (160 mg/dL) or lower and a triglyceride level of 4.0 mmol/L (350 mg/dL) or lower. The active treatment arm received tablets containing 300 mg of garlic powder (Kwai) 3 times per day, given with meals (total, 900 mg/d). This is equivalent to approximately 2.7 g or approximately 1 clove of fresh garlic per day. The placebo arm received an identical-looking tablet, also given 3 times per day with meals. The main outcome measures included levels of total cholesterol, triglycerides, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol after 12 weeks of treatment.


RESULTS
Twenty-eight patients (43% male; mean +/- SD age, 58 +/- 14 years) received garlic powder treatment and 22 (68% male; mean +/- SD age, 57 +/- 13 years) received placebo treatment. There were no significant lipid or lipoprotein changes in either the placebo- or garlic-treated groups and no significant difference between changes in the placebo-treated group compared with changes in the garlic-treated patients.


CONCLUSION
Garlic powder (900 mg/d) treatment for 12 weeks was ineffective in lowering cholesterol levels in patients with hypercholesterolemia.
Application of automatically constructed concept map of learning to conceptual diagnosis of e-learning

The concept map proposed by Novak is a good tool to portray knowledge structure and to diagnose students’ misconception in education. However, most of the learning concept maps have to be constructed through the suggestions of experts or scholars in related realm. It is really a complicated and time-consuming knowledge acquisition process. The study proposed to apply the algorithm of Apriori for Concept Map to develop an intelligent concept diagnostic system (ICDS). It provides teachers with constructed concept maps of learners rapidly, and enables teachers to diagnose the learning barriers and misconception of learners instantly. The best Remedial-Instruction Path (RIP) can be reached through the algorithm of RIP suggested in this study. Furthermore, RIP can be designed to provide remedial learning to learners. Moreover, by using statistical method, the study analyzed 245 students’ data to investigate whether the learning performance of learners can be significantly enhanced after they have been guided by the RIP. 2007 Elsevier Ltd. All rights reserved.
Educational level and the quality of life of heart failure patients: a longitudinal study.

BACKGROUND
Lower education in heart failure (HF) patients is associated with high levels of anxiety, limited physical functioning, and an increased risk of hospitalization. We examined whether educational level is related to longitudinal differences in quality of life (QoL) in HF patients.


METHODS AND RESULTS
This research is a substudy of the Coordinating study evaluating Outcomes of Advising and Counselling in Heart failure (COACH). QoL of 553 HF patients (mean age 69, 38% female, mean left ventricular ejection fraction 33%) was assessed during their hospitalization and at 4 follow-up measurements after discharge. In total 32% of the patients had very low, 24% low, 32% medium, and 12% high education. Patients with low educational levels reported the worst QoL. Significant differences between educational groups (P < .05) were only reported in physical functioning, social functioning, energy/fatigue, pain, and limitations in role functioning related to emotional problems. Longitudinal results show that a significantly higher proportion of high-educated patients improved in functional limitations related to emotional problems over time compared with lower-educated patients (P < .05).


CONCLUSIONS
Patients with low educational levels reported the worst physical and functional condition. High-educated patients improved more than the other patients in functional limitations related to emotional problems over time. Low-educated patients may require different levels of intervention to improve their physical and functional condition.
The effect of pre-weaning housing on the play and agonistic behaviour of domestic pigs

The effect of the pre-weaning housing system on play behaviour before weaning and agonistic behaviour after weaning and during the fattening period was investigated in 32 litters of domestic pigs. Three preweaning housing systems were compared: poor crate (standard farrowing crate without straw), enriched crate (crate with straw, 20% larger), and, as a control, a farrowing pen (pen with straw, 60% larger than the poor crate). At the age of 1, 2 and 4 weeks, play behaviour (locomotor and social play) was recorded for 3 h. Four weeks post-partum, piglets were weaned and two litters from the same housing system were mixed in a new pen, with the stocking density corresponding to density in the pre-weaning poor crate. During mixing, the frequency of agonistic behaviour and the proportion of abnormally ended fights (chasing and biting to the hindquarters of the opponent) were recorded for 3 h, and after 6 h, the number of wounds was counted. Four focal pigs from each litter were chosen (two female and two male) and their agonistic interactions were measured during a food competition test at the age of 3 and 6 months. The pre-weaning housing system tended to have an effect on the frequency of locomotor (GLMM, p < 0.1) and social play (GLMM, p < 0.1) with piglets from the more enriched environments playing more frequently. The pre-weaning housing system did not affect the frequency of agonistic behaviour (GLMM, ns), the number of wounds after mixing (GLMM, ns) or the proportion of abnormally ended fights (GLMM, ns). During the food competition tests at 3 and 6 months pigs reared in the enriched pens were much less aggressive than the pigs reared in both types of crates (GLMM, p < 0.01). Our results suggest that the enrichment of the pre-weaning environment through straw and enlarged space probably stimulate pre-weaning play behaviour and substantially reduces the tendency of pigs to behave aggressively during food competition later in life. However, aggression during post-weaning mixing of piglets does not seem to be affected by pre-weaning enrichment. # 2006 Elsevier B.V. All rights reserved.
A synthetic integral feedback controller for robust tunable regulation in bacteria

We report on the first engineered integral feedback control system in a living cell. The controller is based on the recently published antithetic integral feedback motif [1] which has been analytically shown to have favorable regulation properties. It is implemented along with test circuitry in Escherichia coli using seven genes and three small-molecule inducers. The closed-loop system is highly tunable, allowing a regulated protein of interest to be driven to a desired level and maintained there with precision. Realized using a sigma/anti-sigma protein pair, the integral controller ensures that regulation is maintained in the face of perturbations that lead to the regulated protein’s degradation, thus serving as a proof-of-concept prototype of integral feedback implementation in living cells. When suitably optimized, this integral controller may be utilized as a general-purpose robust regulator for genetic circuits with unknown or partially-known topologies and parameters.
A comparison of the efficacy of an appearance-focused skin cancer intervention within indoor tanner subgroups identified by latent profile analysis

The reduction of intentional exposure to ultraviolet (UV) radiation is an important area of skin cancer prevention. Hillhouse et al. (Cancer 113:3257–3266, 2008) have developed an appearance-focused intervention with evidence of efficacy in lowering indoor tanning UV exposure in young women. In the current study, a subgroup approach was used to determine moderators of intervention efficacy. Undergraduate females in two regions of the United States (n = 362) were randomized into an intervention or control condition. Latent profile analysis was used to identify subgroups of indoor tanners based on patterns of indoor tanning motives. Intervention efficacy was examined within each subgroup. We found evidence for 4 subgroups of tanners: knowledgeable-appearance tanners, low-knowledge tanners, low-knowledge, relaxation tanners, and knowledgeable, low-appearance and low-relaxation tanners. The intervention significantly reduced indoor tanning for the low-knowledge subgroup (34% of the sample). The utility of the subgroup approach in developing targeted behavioral skin cancer interventions is discussed.
Subcutaneous golimumab maintains clinical response in patients with moderate-to-severe ulcerative colitis.

BACKGROUND & AIMS
Subcutaneous golimumab, a fully human monoclonal antibody to tumor necrosis factor-α (TNFα), was evaluated as maintenance therapy in TNFα antagonist-naive adults with moderate-to-severe active ulcerative colitis, despite conventional therapy, who responded to golimumab induction therapy.


METHODS
We performed a phase 3, double-blind trial of patients who completed golimumab induction trials (Program of Ulcerative Colitis Research Studies Utilizing an Investigational Treatment, eg, PURSUIT). Patients who responded to induction therapy with golimumab (n = 464) were assigned randomly to groups given placebo or injections of 50 or 100 mg golimumab every 4 weeks through week 52. Patients who responded to placebo in the induction study continued to receive placebo. Nonresponders in the induction study received 100 mg golimumab. The primary end point was clinical response maintained through week 54; secondary end points included clinical remission and mucosal healing at both weeks 30 and 54.


RESULTS
Clinical response was maintained through week 54 in 47.0% of patients receiving 50 mg golimumab, 49.7% of patients receiving 100 mg golimumab, and 31.2% of patients receiving placebo (P = .010 and P < .001, respectively). At weeks 30 and 54, a higher percentage of patients who received 100 mg golimumab were in clinical remission and had mucosal healing (27.8% and 42.4%) than patients given placebo (15.6% and 26.6%; P = .004 and P = .002, respectively) or 50 mg golimumab (23.2% and 41.7%, respectively). Percentages of serious adverse events were 7.7%, 8.4%, and 14.3% among patients given placebo, 50 mg, or 100 mg golimumab, respectively; percentages of serious infections were 1.9%, 3.2%, and 3.2%, respectively. Among all patients given golimumab in the study, 3 died (from sepsis, tuberculosis, and cardiac failure, all in patients who received 100 mg golimumab) and 4 developed active tuberculosis.


CONCLUSIONS
Golimumab (50 mg or 100 mg) maintained clinical response through week 54 in patients who responded to induction therapy with golimumab and had moderate-to-severe active ulcerative colitis; patients who received 100 mg golimumab had clinical remission and mucosal healing at weeks 30 and 54. Safety was consistent with that reported for other TNFα antagonists and golimumab in other approved indications. ClinicalTrials.gov number: NCT00488631.
BIM ( Building Information Modeling ) and Pedagogical Challenges

BIM is a new building design and documentation methodology that makes the construction process easier and faster for everyone involved. It allows all of the graphical and non-graphical building information for a construction project to be readily available by the use of relational databases. With the emerging concept of BIM, AEC (Architecture, Engineering, and Construction) professionals face new opportunities for enhancing efficiency and refining the practice of building construction. AEC professionals admit that the basic concept of BIM is sound and is the direction in which the AEC industry needs to move.
Literature Review of Cross Language Information Retrieval

Classical Information Retrieval (IR) is the sifting out of the documents most relevant to a user’s information requirement (expressed as a “query”), from a large electronic store of documents. A search engine performs IR by retrieving relevant web pages from the internet. Rather than regarding foreign-language documents simply as unwanted “noise”, Cross Language Information Retrieval allows the user to state their query in one language, and retrieve documents in another. Some CLIR systems use language resources such as bilingual dictionaries to translate the user’s original query, while other systems use machine translation to translate the foreign-language documents beforehand, enabling them to be retrieved by the original query. Problems arise due to ambiguity in language, the use of synonyms to express a single idea, and the lack of context available in translating a short query. This paper will discuss previous work in CLIR, current problems in CLIR, and make recommendations for future work. Keywords-Cross Language Information Retrieval, Lexical Semantics, Disambiguation, Translation.
SET-NORM EXHAUSTIVE SET MULTIFUNCTIONS

In this paper we present some properties of set-norm exhaustive set multifunctions and also of atoms and pseudo-atoms of set multifunctions taking values in the family of non-empty subsets of a commutative semigroup with unity.