LLukas22/scidocs huggingface dataset:
How general practitioners manage children with urinary tract infection: an audit in the former Northern Region.

BACKGROUND
Urinary tract infections (UTIs) in childhood are common and may be difficult to diagnose because of non-specific symptoms and technical problems with urine collection. Active management is important because UTIs may cause permanent renal scarring in young children.


AIM
To determine how general practitioners (GPs) manage children with suspected UTIs.


METHOD
A postal questionnaire to 494 GPs in the former Northern Region (a random selection of 26.2%) asking how they manage children with suspected UTI and their perception of their training needs.


RESULTS
A total of 333 (67.4%) GPs replied. On weekdays, up to 22.9% of GPs treated children who had symptoms suggestive of UTI without collecting a diagnostic urine sample, and up to 64.8% did so at weekends. Urine collection was satisfactory in 73.2% of boys and girls aged under one year, but in only 50.4% of older boys and 48.0% of older girls, caused in part by the use of unreliably 'cleaned' potties in the older group. On weekdays, up to 87.2% of GPs culture the urine, but up to 4.8% use dipsticks as the sole diagnostic test; at weekends, only up to 58.6% culture urines, and up to 19.1% rely on dipsticks alone. Up to 11.0% of GPs examine urine under a microscope for bacteria to test for UTI on weekdays and at weekends. Up to 23.8% of GPs who collect urines on weekdays wait for a positive culture result before starting antibiotics. At weekends, only 3.9% of GPs build in this delay to treatment, mainly because far fewer take urine samples at all. GPs refer younger children for diagnostic imaging more readily than older ones, and boys more readily than girls at all ages. Although virtually all GPs refer all children under five years, some still do so only after recurrent infections. Over half the GPs wanted more training in managing UTI in children.


CONCLUSION
There is a wide variation in clinical practice by GPs. Some always appropriately collect and test urine samples, treat without delay and refer for imaging after one proven UTI. Some never collect urines, treat blindly and refer only young infants with recurrent UTIs. Many vary their standards of practice from weekdays to weekends. The provision for GPs of clear, local, practical guidelines, drawn up between paediatricians and GPs and backed up with study days, might produce a consistent improvement in standards.
Farrowing induction induces transient alterations in prolactin concentrations and colostrum composition in primiparous sows.

Hormonal changes involved in the farrowing process partly control the initiation of lactation. Inducing farrowing by injection of PG may alter the normal prepartum hormonal cascade. The aim of the study was to investigate the consequences of farrowing induction on colostrum yield and composition, as well as newborn piglet growth. Gilts were treated with 2 mg of alfaprostol on d 113 of gestation (induced farrowing, IF, n = 9) or were injected with 1 mL of a saline solution (natural farrowing, NF, n = 11). Colostrum production was estimated during 24 h, starting at the onset of parturition, based on piglet BW gains. Colostrum samples were collected during the 36 h after the onset of parturition. Blood samples were collected from sows as of d 112 of pregnancy until d 2 postpartum (d 0 being the day of parturition). Piglet blood samples were obtained at birth, on d 1, and on d 21. Litter size and litter weight at birth did not differ between groups (P > 0.10). Farrowing induction did not influence (P > 0.10) colostrum yield (3.96 ± 0.20 kg) or piglet BW gain during d 1 postpartum (116 ± 8 g). At the onset of farrowing (T0), lactose content in colostrum was greater in IF sows than in NF sows (P < 0.05), whereas colostrum ash and protein contents were less (P < 0.05) in IF sows. Concentrations of IgG in colostrum were similar in both groups of sows, whereas concentrations of IgA at T0 were less in IF than in NF sows (P < 0.01). Overall, endocrine changes in blood from d -2 until d 2 (cortisol, prolactin, progesterone, and estradiol-17β) were not altered by farrowing induction (P > 0.10), but 1 h after the injection of alfaprostol, IF sows had greater circulating concentrations of prolactin (P < 0.01) and cortisol (P < 0.10) than NF sows. The greater concentration of lactose in colostrum from IF sows could be attributed to this transient increase in prolactin and cortisol. At birth, concentrations of white blood cells were less in piglets born from IF sows (P < 0.01). On d 1 and 21, piglets from IF sows had similar IgG concentrations in plasma to piglets from NF sows (P > 0.1). In conclusion, farrowing induction at 113 d of pregnancy induced transient hormonal changes in sows and alterations in colostrum composition, without significantly affecting colostrum yield. It also modified some hematological variables of piglets at birth.
Patients' perceptions of electronic monitoring devices affect medication adherence in hypertensive African Americans.

BACKGROUND
Electronic monitoring devices (EMDs) are regarded as the gold standard for assessing medication adherence in clinical research. However, little is known about the effect of patients' acceptance of EMDs on medication adherence in African Americans with hypertension who are followed in primary care practices


OBJECTIVE
To assess patients' perceptions of EMDs, their acceptance of EMDs, and the relationship of these perceptions to medication adherence in African Americans with hypertension who are followed in community-based practices.


METHODS
Patients were recruited from a larger randomized controlled trial assessing the effect of motivational interviewing on medication adherence and blood pressure in hypertensive African American patients followed in 2 New York City primary care practices. Medication adherence was assessed with a Medication Event Monitoring System (MEMS) during a 12-month monitoring period. At the 12-month follow-up, patients' perceptions of the MEMS were assessed with a 17-item questionnaire. ANOVA was used to compare patients' responses (agree, neither, disagree) with the MEMS adherence over the monitoring period. Tukey's post hoc tests were used to determine whether there were significant differences among the 3 groups.


RESULTS
Participants were predominantly women, low-income, unemployed, had a high school education, and were a mean age of 53 years. Approximately two-thirds of the participants stated that the MEMS helped them remember to take their medications, 93% reported that the MEMS was easy to open, 85% did not find it stressful, and 75% liked the MEMS and used it everyday. One-third of patients preferred using a pillbox and 25% did not like traveling with the MEMS. Patients who stated that they used the MEMS every day, felt comfortable using it in front of others, and remembered to put refills in the MEMS had significantly better adherence over the study period than did those who disagreed (p </= 0.05).


CONCLUSIONS
African American patients treated for hypertension in community-based practices held positive perceptions about a MEMS. Perceptions about the practicality of a MEMS may yield important information about actual medication-taking behavior.
A high voltage pulse-generator based on DC-to-DC converters and capacitor-diode voltage multipliers for water treatment applications

Pulsed electric field (PEF) can be used effectively in water treatment applications by passing infected water through two electrodes excited from a high voltage pulsed power supply which guarantees killing the harmful germs. In this paper, a new high-voltage pulse-generator with closed loop control of its output voltage is presented for treating water via underwater pulsed streamer corona discharge. The proposed generator is fed from a low AC voltage source (utility mains 220 V, 50 Hz) which makes it suitable for domestic applications. The proposed topology provides transformer-less operation which reduces the system size and enhances the overall efficiency. The proposed topology is based on capacitor-diode voltage multiplier (CDVM) circuits in conjunction with DC-DC converters (Boost and Buck-Boost converters). The simulation and experimental results elucidate the proposed configuration.
Gate Oxide Reliability Issues of SiC MOSFETs Under Short-Circuit Operation

Silicon-Carbide (SiC) MOSFETs, due to material properties, are designed with smaller thickness in the gate oxide and a higher electric field compared to Si MOSFETs. Consequently, the SiC MOSFETs have a worse reliability which causes higher leakage currents during instantaneous abnormal operating conditions. This paper investigates the reliability issues of the SiC MOSFET gate oxide under standard short-circuit test conditions. In this paper, 1200-V SiC MOSFETs are newly modeled, and also their short-circuit sustainability (tolerance) have been studied at different drain-source and gate-source voltages. A hardware tester circuit was designed and developed to test the devices under such extreme circuit conditions. Then, the gate reliability of SiC MOSFET devices have been compared to that of Si power devices of similar ratings. The results reveal a higher reduction in the instantaneous gate-source voltage of SiC MOSFETs compared to that of Si devices under the same operating conditions. The gate-voltage reduction phenomenon results from the higher leakage currents through the gate. Furthermore, it was found that the gate-source voltage reduction during the test depends on the gate structures. The gate voltage reduction of SiC MOSFETs with planar gate is higher than that of MOSFETs with shield planar gate. As the pulse duration increases in short-circuit tests, the leakage current in the gate-source of SiC devices increases. The results show that even though the SiC MOSFETs are very capable of processing long pulses and high power in the drain-source, the gate-source side is highly degraded by these pulses in the test. Moreover, whenever a small number of the short-circuit tests are applied, the gate structure of SiC MOSFETs becomes broken while the drain-source is still able to block the dc-link voltage. The paper concludes that the short-circuit reliability of the gate was found to be worse compared with commercial Si devices with similar rating.
Quality of Life Philosophy I. Quality of Life, Happiness, and Meaning in Life

In the Danish Quality of Life Survey, we asked 10,000 people about their quality of life with the validated SEQOL questionnaire with more than 300 questions on their quality of life. How did they feel? How content were they with their lives? How happy were they? Did they feel their needs were fulfilled? And many more questions. We asked the questions we believed to be important for their quality of life (QOL). The results were quite surprising and forced us to recontemplate the following philosophical questions: What is quality of life, happiness, and meaning in life? What is a human being? Do we need a new biology? Is the brain the seat of consciousness? How do we seize the meaning of life and by doing so, will we become well again? What are the key concepts of quality of life? The meaning of life is connectedness and development. It is about realizing every opportunity and potential in one"s existence. The opportunities must be found and acknowledged. What do you find when you find yourself deep down? You find your real self and your purpose in life. You realize that you are already a part of a larger totality. Antonovsky called it "coherence". Maslow called it "transcendence". Frankl called it "meaning of life". We call it simply "being". To test if these philosophical questions are actually relevant for medicine, we looked at the consequences for patients being taught the quality of life philosophy. Quite surprisingly we learned from our pilot studies with "quality of life as medicine" that just by assimilating the basic concepts of the quality of life philosophy presented in this series of papers, patients felt better and saw their lives as more meaningful. The improvement of the patient"s personal philosophy of life seems to be the essence of holistic medicine, helping the patient to assume more responsibility for his or her own existence.
Analysis of titanium dioxide and zinc oxide nanoparticles in cosmetics.

There have been rapid increases in consumer products containing nanomaterials, raising concerns over the impact of nanoparticles (NPs) to humankind and the environment, but little information has been published about mineral filters in commercial sunscreens. It is urgent to develop methods to characterize the nanomaterials in products. Titanium dioxide (TiO2) and zinc oxide (ZnO) NPs in unmodified commercial sunscreens were characterized by laser scanning confocal microscopy, atomic force microscopy, X-ray diffraction (XRD), and transmission electron microscopy (TEM). The results showed that laser scanning confocal microscopy evaluated primary particle aggregates and dispersions but could not size NPs because of the diffraction limited resolution of optical microscopy (200 nm). Atomic force microscopy measurements required a pretreatment of the sunscreens or further calibration in phase analysis, but could not provide their elemental composition of commercial sunscreens. While XRD gave particle size and crystal information without a pretreatment of sunscreen, TEM analysis required dilution and dispersion of the commercial sunscreens before imaging. When coupled with energy-dispersive X-ray spectroscopy, TEM afforded particle size information and compositional analysis. XRD characterization of six commercial sunscreens labeled as nanoparticles revealed that three samples contained TiO2 NPs, among which two listed ZnO and TiO2, and displayed average particle sizes of 15 nm, 21 nm, and 78 nm. However, no nanosized ZnO particles were found in any of the samples by XRD. In general, TEM can resolve nanomaterials that exhibit one or more dimensions between 1 nm and 100 nm, allowing the identification of ZnO and TiO2 NPs in all six sunscreens and ZnO/TiO2 mixtures in two of the samples. Overall, the combination of XRD and TEM was suitable for analyzing ZnO and TiO2 NPs in commercial sunscreens.
Making Machines Understand Us in Reverberant Rooms: Robustness Against Reverberation for Automatic Speech Recognition

Speech recognition technology has left the research laboratory and is increasingly coming into practical use, enabling a wide spectrum of innovative and exciting voice-driven applications that are radically changing our way of accessing digital services and information. Most of today's applications still require a microphone located near the talker. However, almost all of these applications would benefit from distant-talking speech capturing, where talkers are able to speak at some distance from the microphones without the encumbrance of handheld or body-worn equipment [1]. For example, applications such as meeting speech recognition, automatic annotation of consumer-generated videos, speech-to-speech translation in teleconferencing, and hands-free interfaces for controlling consumer-products, like interactive TV, will greatly benefit from distant-talking operation. Furthermore, for a number of unexplored but important applications, distant microphones are a prerequisite. This means that distant talking speech recognition technology is essential for extending the availability of speech recognizers as well as enhancing the convenience of existing speech recognition applications.
The Effect of a Combined Visual Efficiency and Perceptual-Motor Training Programme on the Handwriting Performance of Children with Handwriting Difficulties : A Pilot Study

Background: The purpose of this study was to investigate the effect of a combined visual efficiency and perceptual-motor training programme on the handwriting performance of Chinese children aged 6 to 9 years with handwriting difficulties (HWD). Methods: Twenty-six children with HWD were assigned randomly and equally into two groups. The training programme was provided over eight consecutive weeks with one session per week. The perceptual-motor group received training only on perceptual-motor functions, including visual spatial relationship, visual sequential memory, visual constancy, visual closure, graphomotor control and grip control. The combined training group received additional training components on visual efficiency, including accommodation, ocular motility, and binocular fusion. Visual efficiency, visual perceptual skills, and Chinese handwriting performance were assessed before and after the training programme. Results: The results showed statistically significant improvement in handwriting speed after the training in both groups. However, the combined training gave no additional benefit on improving handwriting speed (ANCOVA: F=0.43, p=0.52). In terms of visual efficiency, participants in the combined training group showed greater improvement in amplitude of accommodation measured with right eye (F=4.34, p<0.05), left eye (F=5.77, p<0.05) and both eyes (F=11.08, p<0.01). Conclusions: Although the additional visual efficiency training did not provide further improvement in the handwriting speed of children with HWD, children showed improvement in their accommodation amplitude. As accommodative function is important for providing sustainable and clear near vision in the process of reading and word recognition for writing, the effect of the combined training on handwriting performance should be further investigated.
Mapping the brain's metaphor circuitry: metaphorical thought in everyday reason

An overview of the basics of metaphorical thought and language from the perspective of Neurocognition, the integrated interdisciplinary study of how conceptual thought and language work in the brain. The paper outlines a theory of metaphor circuitry and discusses how everyday reason makes use of embodied metaphor circuitry.
An overview of interpretive phenomenology as a research methodology.

AIM
To provide an overview of interpretive phenomenology.


BACKGROUND
Phenomenology is a philosophy and a research approach. As a research approach, it is used extensively in nursing and 'interpretive' phenomenology is becoming increasingly popular.


DATA SOURCES
Online and manual searches of relevant books and electronic databases were undertaken.


REVIEW METHODS
Literature review on papers on phenomenology, research and nursing (written in English) was undertaken.


DISCUSSION
A brief outline of the origins of the concept, and the influence of 'descriptive' phenomenology on the development of interpretive phenomenology is provided. Its aim, origins and philosophical basis, including the core concepts of dasein, fore-structure/pre-understanding, world view existential themes and the hermeneutic circle, are described and the influence of these concepts in phenomenological nursing research is illustrated.


CONCLUSION
This paper will assist readers when deciding whether interpretive phenomenology is appropriate for their research projects.


IMPLICATIONS FOR RESEARCH/PRACTICE
This paper adds to the discussion on interpretive phenomenology and helps inform readers of its use as a research methodology.
22.5 A 93%-power-efficiency photovoltaic energy harvester with irradiance-aware auto-reconfigurable MPPT scheme achieving >95% MPPT efficiency across 650µW to 1W and 2.9ms FOCV MPPT transient time

With more and more functions in modern battery-powered mobile devices, enabling light-harvesting in the power management system can extend battery usage time [1]. For both indoor and outdoor operations of mobile devices, the output power range of the solar panel with the size of a touchscreen can vary from 100s of µW to a Watt due to the irradiance-level variation. An energy harvester is thus essential to achieve high maximum power-point tracking efficiency (ηT) over this wide power range. However, state-of-the-art energy harvesters only use one maximum power-point tracking (MPPT) method under different irradiance levels as shown in Fig. 22.5.1 [2–5]. Those energy harvesters with power-computation-based MPPT schemes for portable [2,3] and standalone [4] systems suffer from low ηT under low input power due to the limited input dynamic range of the MPPT circuitry. Other low-power energy harvesters with the fractional open-cell voltage (FOCV) MPPT scheme are confined by the fractional-constant accuracy to only offer high ηT across a narrow power range [5]. Additionally, the conventional FOCV MPPT scheme requires long transient time of 250ms to identify MPP [5], thereby significantly reducing energy capture from the solar panel. To address the above issues, this paper presents an energy harvester with an irradiance-aware hybrid algorithm (IAHA) to automatically switch between an auto-zeroed pulse-integration based MPPT (AZ PI-MPPT) and a slew-rate-enhanced FOCV (SRE-FOCV) MPPT scheme for maximizing ηT under different irradiance levels. The SRE-FOCV MPPT scheme also enables the energy harvester to shorten the MPPT transient time to 2.9ms in low irradiance levels.
A Multicenter Retrospective Review of Prone Position Ventilation (PPV) in Treatment of Severe Human H7N9 Avian Flu

BACKGROUND
Patients with H7N9 avian flu concurrent with severe acute respiratory distress syndrome (ARDS) usually have a poor clinical outcome. Prone position ventilation (PPV) has been shown to improve the prognosis of patients with severe ARDS. This study explored the effects of PPV on the respiratory and circulatory mechanics of H7N9-infected patients with severe ARDS.


METHODS
Individuals admitted to four hospitals designated for H7N9 patients in Guangdong province were treated with PPV, and their clinical data were recorded before and after receiving PPV.


RESULTS
Six of 20 critically ill patients in the ICU received PPV. After treatment with 35 PPV sessions, the oxygenation index (OI) values of the six patients when measured post-PPV and post-supine position ventilation (SPV) were significantly higher than those measured pre-PPV (P < 0.05).The six patients showed no significant differences in their values for respiratory rate (RR), peak inspiratory pressure (PIP), tidal volume (TV) or arterial partial pressure of carbon dioxide (PaCO2) when compared pre-PPV, post-PPV, and post-SPV. Additionally, there were no significant differences in the mean values for arterial pressure (MAP), cardiac index (CI), central venous pressure (CVP), heart rate (HR), lactic acid (LAC) levels or the doses of norepinephrine (NE) administered when compared pre-PPV, post-PPV, and post-SPV.


CONCLUSION
PPV provided improved oxygenation that was sustained after returning to a supine position, and resulted in decreased carbon dioxide retention. PPV can thus serve as an alternative lung protective ventilation strategy for use in patients with H7N9 avian flu concurrent with severe ARDS.