LLukas22/scidocs huggingface dataset:
Randomized trial of radiation-free central nervous system prophylaxis comparing intrathecal triple therapy with liposomal cytarabine in acute lymphoblastic leukemia.

Developing optimal radiation-free central nervous system prophylaxis is a desirable goal in acute lymphoblastic leukemia, to avoid the long-term toxicity associated with cranial irradiation. In a randomized, phase II trial enrolling 145 adult patients, we compared intrathecal liposomal cytarabine (50 mg: 6/8 injections in B-/T-cell subsets, respectively) with intrathecal triple therapy (methotrexate/cytarabine/prednisone: 12 injections). Systemic therapy included methotrexate plus cytarabine or L-asparaginase courses, with methotrexate augmented to 2.5 and 5 g/m(2) in Philadelphia-negative B- and T-cell disease, respectively. The primary study objective was the comparative assessment of the risk/benefit ratio, combining the analysis of feasibility, toxicity and efficacy. In the liposomal cytarabine arm 17/71 patients (24%) developed grade 3-4 neurotoxicity compared to 2/74 (3%) in the triple therapy arm (P=0.0002), the median number of episodes of neurotoxicity of any grade was one per patient compared to zero, respectively (P=0.0001), and even though no permanent disabilities or deaths were registered, four patients (6%) discontinued intrathecal prophylaxis on account of these toxic side effects (P=0.06). Neurotoxicity worsened with liposomal cytarabine every 14 days (T-cell disease), and was improved by the adjunct of intrathecal dexamethasone. Two patients in the liposomal cytarabine arm suffered from a meningeal relapse (none with T-cell disease, only one after high-dose chemotherapy) compared to four in the triple therapy arm (1 with T-cell disease). While intrathecal liposomal cytarabine could contribute to improved, radiation-free central nervous system prophylaxis, the toxicity reported in this trial does not support its use at 50 mg and prompts the investigation of a lower dosage. (clinicaltrials.gov identifier: NCT-00795756).
On Hard Adders and Carry Chains in FPGAs

Hardened adder and carry logic is widely used in commercial FPGAs to improve the efficiency of arithmetic functions. There are many design choices and complexities associated with such hardening, including circuit design, FPGA architectural choices, and the CAD flow. There has been very little study, however, on these choices and hence we explore a number of possibilities for hard adder design. We also highlight optimizations during front-end elaboration that help ameliorate the restrictions placed on logic synthesis by hardened arithmetic. We show that hard adders and carry chains, when used for simple adders, increase performance by a factor of four or more, but on larger benchmark designs that contain arithmetic, improve overall performance by roughly 15%. We measure an average area increase of 5% for architectures with carry chains but believe that better logic synthesis should reduce this penalty. Interestingly, we show that adding dedicated inter-logic-block carry links or fast carry look-ahead hardened adders result in only minor delay improvements for complete designs.
Deep space environments for human exploration.

Mission scenarios outside the Earth's protective magnetic shield are being studied. Included are high usage assets in the near-Earth environment for casual trips, for research, and for commercial/operational platforms, in which career exposures will be multi-mission determined over the astronaut's lifetime. The operational platforms will serve as launching points for deep space exploration missions, characterized by a single long-duration mission during the astronaut's career. The exploration beyond these operational platforms will include missions to planets, asteroids, and planetary satellites. The interplanetary environment is evaluated using convective diffusion theory. Local environments for each celestial body are modeled by using results from the most recent targeted spacecraft, and integrated into the design environments. Design scenarios are then evaluated for these missions. The underlying assumptions in arriving at the model environments and their impact on mission exposures within various shield materials will be discussed.
Cancellation of Surgeries: Integrative Review.

PURPOSE
To analyze cancellations of surgeries and identify evidence-based interventions to address this issue.


DESIGN
Integrative literature review.


METHODS
An integrative literature search was conducted in four databases: CINAHL, PubMed, Embase, and Cochrane and included literature sources dated January 2011 to January 2016. The complete list of search terms consisted of the following: ambulatory surgery, day surgery center, elective surgical procedure, elective operation, elective surgery, schedule, access to care, surgery cancellation, operation cancellation, and surgery delay.


FINDINGS
Twenty-three literature sources were identified. Evidence included one randomized controlled trial and multiple studies. Causes of cancellations were classified into three categories: hospital-related reasons, patient-related reasons, and surgeon-related reasons. Evidence confirmed most cancellations were avoidable.


CONCLUSIONS
Cancellation of scheduled surgeries has a significant impact on patients' health, resources, cost, and quality of care. It is difficult to devise a solution without understanding the cause of cancellations.
Electrochemistry of carbon dioxide corrosion mitigation using tall oil diethylenetriamine imidazoline as corrosion inhibitor for mild steel

The inhibition effect of tall oil diethylenetriamine imidazoline (TOFA/DETA imidazoline) on corrosion of mild steel in CO2-saturated 3wt% NaCl solution was investigated by electrochemical impedance spectroscopy (EIS), potentiodynamic sweep (PDS), cyclic voltammetry (CV), quartz crystal microbalance measurements (QCM), and scanning electron microscopy (SEM). TOFA/DETA imidazoline is a mixed-type corrosion inhibitor with the predominant anodic effect. The results of CV measurements indicate inhibited electrode processes in the presence of TOFA/DETA imidazoline and the absence of the rapid degradation of TOFA/DETA imidazoline in the range of mild steel corrosion potential. The corrosion rate of mild steel significantly decreased in the presence of TOFA/DETA imidazoline, while the inhibition efficiency increased up to 92%. It was found that the adsorption of studied imidazoline compound on steel surface followed both Langmuir and Temkin adsorption isotherms. The value of molecular interaction constant calculated from Temkin adsorption isotherm implied the existence of lateral repulsion between adsorbed inhibitor molecules.
Relation and object in Plato's approach to knowledge

THE aim of this paper is to explain a paradox in Plato's philosophy. On the one hand, Plato reduces virtue to knowledge; on the other, he rejects the possibility of knowledge or at least has serious doubts that it exists. I shall propose in this paper that the definition of virtue as knowledge is a logical outcome of Plato's denial of the particular aspect of knowledge as cognitive relation. This paper may also be considered as an attempt to resolve the Hintikka-Santas polemic about whether there is a difference in Plato's philosophy between the function of knowledge and its object. ([3], [6] pp. 1–71). 
 
The first part of this paper consists in a critical exposition of Plato's rejection of cognitive relation as a function of knowledge. The second part is devoted to an account of Plato's assumptions in this regard. In the third section of the paper I shall show how, on the basis of these assumptions, Plato reduces virtue to knowledge. And finally, in the last section of the essay, I shall compare my interpretation of this issue with other modern interpretations, especially those of Gerasimos Santas and Jaakko Hintikka.
Broadband Wireless Delivery Using an Inside-Out TV White Space Network Architecture

In this paper we investigate the feasibility of wireless broadband delivery using an "inside-out" community network architecture, where residential broadband customers share a portion of their home access point bandwidth for outdoor public use. We use system simulation studies performed for real-life BT FON service scenarios in the UK to investigate the feasibility of a blanket wireless broadband coverage provision in various residential environments using this architecture. It is found that due to interference effects it is in principle not possible to achieve blanket coverage using WiFi access points operating in the 2.4 GHz band, even when there is 100% penetration of access point. Switching to the 5.GHz mitigates interference but does not achieve blanket coverage due to range limitation of this spectral band. Using realistic estimates of TVWS availability in the UK obtained using a geolocation database; we show that by enabling community access point to operate in TV White Spaces, ubiquitous coverage could be achieved in urban environments with less than 20% penetration of access points. Our finding indicates that, at least for data traffic, community networks operating in TV White Space spectrum are a viable and significantly less expensive alternative to the cellular operators' next generation network. Our study also points out to a greater need for interference management techniques in TVWS networks than WiFi networks due to increased RF coverage in TV bands.
Program Algorithm Research of T2 Spectrum in NMR and MATLAB Realization

A multi-exponential T2 inversion method for NMR relaxation signals is presented and tested, which is based on the thought of algorithm for singular value decomposition (SVD). This method is realized in MATLAB. The concrete implementation process for SVD is discussed in detail, and some SVD inversion modeling and practical data collected from the NMR analyst instrument are calculated. The paper give the multi-exponential T2 inversion results in different SNR, and the method to echo train processing is introduced, the algorithm is a valuable reference for NMR inversion software development. Keywords-NMR; multi-exponential inversion relaxation; SVD; MATLAB
Resistance to insulin therapy among patients and providers: results of the cross-national Diabetes Attitudes, Wishes, and Needs (DAWN) study.

OBJECTIVE
To examine the correlates of patient and provider attitudes toward insulin therapy.


RESEARCH DESIGN AND METHODS
Data are from surveys of patients with type 2 diabetes not taking insulin (n = 2,061) and diabetes care providers (nurses = 1,109; physicians = 2,681) in 13 countries in Asia, Australia, Europe, and North America. Multiple regression analysis is used to identify correlates of attitudes toward insulin therapy among patients, physicians, and nurses.


RESULTS
Patient and provider attitudes differ significantly across countries, controlling for individual characteristics. Patients rate the clinical efficacy of insulin as low and would blame themselves if they had to start insulin therapy. Self-blame is significantly lower among those who have better diet and exercise adherence and less diabetes-related distress. Patients who are not managing their diabetes well (poor perceived control, more complications, and diabetes-related distress) are significantly more likely to see insulin therapy as potentially beneficial. Most nurses and general practitioners (50-55%) delay insulin therapy until absolutely necessary, but specialists and opinion leaders are less likely to do so. Delay of insulin therapy is significantly less likely when physicians and nurses see their patients as more adherent to medication or appointment regimens, view insulin as more efficacious, and when they are less likely to delay oral diabetes medications.


CONCLUSIONS
Patient and provider resistance to insulin therapy is substantial, and for providers it is part of a larger pattern of reluctance to prescribe blood glucose-lowering medication. Interventions to facilitate timely initiation of insulin therapy will need to address factors associated with this resistance.
Chronomodulated irinotecan, oxaliplatin, and leucovorin-modulated 5-Fluorouracil as ambulatory salvage therapy in patients with irinotecan- and oxaliplatin-resistant metastatic colorectal cancer.

PURPOSE
To evaluate the activity and tolerability of salvage chronomodulated chemotherapy combining irinotecan (I), 5-fluorouracil/leucovorin (5-FU/LV), and oxaliplatin (O) (chronoIFLO) in patients with metastatic colorectal cancer (MCRC) and prior progression on four drugs.


PATIENTS AND METHODS
Seventy-seven nonhospitalized MCRC patients received chronoIFLO every 3 weeks, with day 1: I (180 mg/m2 over 6 hours, with peak infusion rate at 05:00) and days 2-5: 5-FU/LV (700/300 mg/m2 per day over 12 hours, with peak flow rate at 04:00), and O (20 mg/m2 per day over 12 hours, with peak flow rate at 16:00). Toxicity and response were assessed every 3 weeks and every 2 months, respectively. RESULTS. Three or more prior chemotherapy lines were given to 75% of the patients. Two or more organs had metastatic disease in 65% of the patients. A median number of six courses of chronoIFLO was given. The main grade 3-4 toxicities were diarrhea (39% of the patients, 9% of the courses) and neutropenia (30% of the patients and 7% of the courses). Grade 3 peripheral sensory neuropathy occurred in 14% of the patients. Two patients achieved a partial response and 61 had stable disease, resulting in disease control for 82% of the patients. The median time to progression (TTP) was 5.5 months (95% confidence interval, 3.7-6.0). The median overall survival time was 14.2 months (9.8-17.3). Baseline performance status, serum carcinoembryonic antigen (CEA) level, and CEA doubling time were independent prognostic factors of TTP.


CONCLUSIONS
ChronoIFLO safely and durably halted tumor progression in most extensively pretreated MCRC patients.
A Bayesian encourages dropout

Dropout is one of the key techniques to prevent the learning from overfitting. It is explained that dropout works as a kind of modified L2 regularization. Here, we shed light on the dropout from Bayesian standpoint. Bayesian interpretation enables us to optimize the dropout rate, which is beneficial for learning of weight parameters and prediction after learning. The experiment result also encourages the optimization of the dropout.
Photoablation using the turbo-booster and excimer laser for in-stent restenosis treatment: twelve-month results from the PATENT study.

PURPOSE
To evaluate the performance of the Turbo Elite laser catheter in combination with the Turbo-Booster guiding catheter for the treatment of femoropopliteal in-stent restenosis (ISR).


METHODS
The PATENT study (Photoablation Using the Turbo-Booster and Excimer Laser for In-Stent Restenosis Treatment) was a multicenter prospective industry-sponsored registry involving 5 European centers. Patients with symptomatic femoropopliteal ISR (Rutherford categories 2-5) and an ankle-brachial index ≤0.8 were treated with excimer laser atherectomy (ELA). Ninety patients (65 men; mean age 69.5±9.3 years) were enrolled. The majority of patients were Rutherford category 3 (63, 71.6%), and 32 (35.6%) patients had previous treatment for ISR. The average lesion length was 123±95.9 mm, and 30 (34.1%) lesions were total occlusions. The main efficacy outcome was primary patency at 12 months as measured by duplex ultrasonography. The primary safety outcome was freedom from major adverse events (MAE) during hospitalization and at 30-day follow-up to include all death, unplanned major amputation, or target lesion revascularization (TLR).


RESULTS
The Turbo Elite laser catheter created a pilot channel in 87 (96.7%) of 90 lesions, with a mean of 1.5 passes, followed by the Turbo Booster with a mean of 5.7 passes. Adjunctive balloon dilation was performed in 79 (87.8%) lesions. Procedure success (<30% residual stenosis without stenting) was 96.7%. The mean percentage stenosis improved from a baseline of 87.0% to 32.3% after laser atherectomy and to 7.4% after final treatment. The MAE rate through 30 days was 2.2%. Nine (10.0%) patients experienced distal embolization. Estimates of freedom from TLR at 6 and 12 months were 87.8% and 64.4%, respectively. Primary patency at 6 and 12 months was 64.1% and 37.8%, respectively. Only a history of prior intervention for ISR (p<0.01) was a predictor of TLR at 12 months.


CONCLUSION
The PATENT study has established excimer laser atherectomy as safe for the treatment of femoropopliteal ISR, achieving high procedure success. Recurrence of restenosis indicates that removing hyperproliferative tissue alone does not solve the problem of ISR. New concepts, such as the combination of ELA with drug-eluting balloons, may prove beneficial.
Diagnosis and management of fibromuscular dysplasia: an expert consensus.

Alexandre Persu, Emmanuel Touzé, Elie Mousseaux, Xavier Barral, Francis Joffre and Pierre-François Plouin Division of Cardiology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium, Department of Neurology, Université Paris Descartes, INSERM UMR S894, Pôle neuroscience, Hôpital Sainte-Anne, Paris, France, Department of Radiology, Université Paris Descartes, Hôpital Européen Georges Pompidou, Paris, France, Department of Vascular Surgery, CHU Hôpital Nord, Saint-Etienne, France, Department of Radiology, Rangueil University Hospital, Toulouse, France, Université Paris-Descartes; Assistance Publique-Hôpitaux de Paris; Hôpital Européen Georges Pompidou, Hypertension Unit, Paris, France
Perceived usefulness, personal experiences, risk perception and trust as determinants of adoption of e-government services in The Netherlands

Recently Dutch government, as well as many other governments around the world, has digitized a major portion of its public services. With this development electronic services finally arrive at the transaction level. The risks of electronic services on the transactional level are more profound than at the informational level. The public needs to trust the integrity and ‘information management capacities’ of the government or other involved organizations, as well as trust the infrastructure and those managing the infrastructure. In this process, the individual citizen will have to decide to adopt the new electronic government services by weighing its benefits and risks. In this paper, we present a study which aims to identify the role of risk perception and trust in the intention to adopt government e-services. In January 2003, a sample of 238 persons completed a questionnaire. The questionnaire tapped people’s intention to adopt e-government electronic services. Based on previous research and theories on technology acceptance, the questionnaire measured perceived usefulness of e-services, risk perception, worry, perceived behavioural control, subjective norm, trust and experience with e-services. Structural equation modelling was used to further analyze the data (Amos) and to design a theoretical model predicting the individual’s intention to adopt e-services. This analysis showed that the perceived usefulness of electronic services in general is the main determinant of the intention to use e-government services. Risk perception, personal experience, perceived behavioural control and subjective norm were found to significantly predict the perceived usefulness of electronic services in general, while trust in e-government was the main determinant of the perceived usefulness of e-government services. 2006 Elsevier Ltd. All rights reserved. 0747-5632/$ see front matter 2006 Elsevier Ltd. All rights reserved. doi:10.1016/j.chb.2005.11.003 * Corresponding author. E-mail addresses: Margot.Kuttschreuter@utwente.nl (M. Kuttschreuter), J.M.Gutteling@utwente.nl (J.M. Gutteling). M. Horst et al. / Computers in Human Behavior 23 (2007) 1838–1852 1839
The SLICK hair locus derived from Senepol cattle confers thermotolerance to intensively managed lactating Holstein cows.

The SLICK haplotype (http://omia.angis.org.au/OMIA001372/9913/) in cattle confers animals with a short and sleek hair coat. Originally identified in Senepol cattle, the gene has been introduced into Holsteins. The objectives of the current study were to determine (1) whether lactating Holsteins with the slick hair phenotype have superior ability for thermoregulation compared with wild-type cows or relatives not inheriting the SLICK haplotype, and (2) whether seasonal depression in milk yield would be reduced in SLICK cows. In experiment 1, diurnal variation in vaginal temperature in the summer was monitored for cows housed in a freestall barn with fans and sprinklers. Vaginal temperatures were lower in slick-haired cows than in relatives and wild-type cows. In experiment 2, acute responses to heat stress were monitored after cows were moved to a dry lot in which the only heat abatement was shade cloth. The increases in rectal temperature and respiration rate caused by heat stress during the day were lower for slick cows than for relatives or wild-type cows. Moreover, sweating rate was higher for slick cows than for cows of the other 2 types. In experiment 3, effects of season of calving (summer vs. winter) on milk yield and composition were determined. Compared with milk yield of cows calving in winter, milk yield during the first 90 d in milk was lower for cows calving in the summer. However, this reduction was less pronounced for slick cows than for wild-type cows. In conclusion, Holsteins with slick hair have superior thermoregulatory ability compared with non-slick animals and experience a less drastic depression in milk yield during the summer.
Using the Saint George's Respiratory Questionnaire to evaluate quality of life in patients with chronic obstructive pulmonary disease: validating a new version for use in Brazil.

OBJECTIVE
The objective of this study was to evaluate the applicability of a modified version of the Saint George's Respiratory Questionnaire. The version evaluated elicits "agree" and "do not agree", rather than "yes" and "no", responses. The intention is to facilitate the comprehension of double-negative questions and to promote better recollection of symptoms by patients by shortening their symptom histories from 12 months to 3 months.


METHODS
A total of 30 clinically stable patients with chronic obstructive pulmonary disease were evaluated. The Saint George's Respiratory Questionnaire and the modified version of the same were administered 15 days apart.


RESULTS
All of the patients presented health-related alterations in their quality of life. Comparing mean scores between the two questionnaires, the greatest difference was seen in the Symptoms domain. No significant differences were found in any of the remaining domains or in the total scores. In a subsequent analysis, significant correlations between the two questionnaires were found in all domains: Symptoms (r = 0.71; p < 0.001); Activity (r = 0.75; p < 0.001); Impact (r = 0.73; p < 0.001) and Total (r = 0.86; p < 0.001).


CONCLUSION
The modified version of the Saint George's Respiratory Questionnaire is as effective as the original in gauging quality of life. However, various symptoms recollection time frames should be investigated in order to determine which would be the best time frame to employ in the analysis.