LLukas22/scidocs huggingface dataset:
A Study on Weibull Distribution for Estimating the Parameters

The wind resource varies with of the day and the season of the year and even some extent from year to year. Wind energy has inherent variances and hence it has been expressed by distribution functions. In this paper, we present some methods for estimating Weibull parameters, namely, shape parameter ( k ) and scale parameter ( c ). The Weibul distribution is an important distribution especially for reliability and maintainability analysis. The suitable values for both shape parameter and scale parameters of Weibull distribution are important for selecting locations of installing wind turbine generators. The scale parameter of Weibull distribution also important to determine whether a wind farm is good or not. The presented method is the analytical methods and computational experiments on the presented methods are reported.
Growth and development of the mammary glands of livestock: a veritable barnyard of opportunities.

The mammary glands of all mammals are rich and diverse in their histomorphogenesis, developmental biology, genomics and metabolism. Domesticated livestock comprise a unique population for the analysis of mammary gland and lactation biology, where much of what has been learned about these topics originates from studies of these species. However, with the strong trend toward using rodents as flexible and attractive models for normal mammary biology and cancer, there is a growing void of new information related to biology of the mammary glands in these relevant and informative domestic livestock. In turn, this trend threatens to reduce opportunities to either capitalize on an abundance of pre-existing data or to apply this information to studies of lactation and cancer. Herein we review the unique and discerning features of mammary gland development in several domestic livestock species including cows, sheep and pigs and provide an overview of the factors regulating it. At the same time we discuss some of the key considerations for studying these species, their limitations, and the associated opportunities. From such an analysis it quickly becomes clear that much remains to be learned about the mammary glands of domestic livestock, particularly given their many similarities to the human breast, the unique biological mechanisms they employ, and the phenotypic variation they afford.
Penalized spline smoothing in multivariable survival models with varying coefficients

The paper discusses penalised spline (P -spline) smoothing for hazard regression of multivariable survival data. Non-proportional hazard functions are fitted in a numerically handy manner by employing Poisson regression which results from numerical integration of the cumulative hazard function. Multivariate smoothing parameters are selected by utilizing the connection between P -spline smoothing and Generalised Linear Mixed Models. A hybrid routine is suggested which combines the Mixed Model idea with a classical Akaike information criteria. The model is evaluated with simulations and applied to data on the success and failure of newly founded companies.
Cooperative biological effects between ionizing radiation and other physical and chemical agents.

Exposure to ionizing radiation (IR), at environmentally and therapeutically relevant doses or as a result of diagnostics or accidents, causes cyto- and genotoxic damage. However, exposure to IR alone is a rare event as it occurs in spatial and temporal combination with several physico-chemical agents. Some of these are of known noxiousness, as is the case with chemical compounds at high dose, hence additive/synergistic effects can be expected or have been demonstrated. Conversely, the cellular toxicity of other agents, such as non-ionizing electromagnetic fields (EMFs), is only presumed and their short- and long-term cooperation on IR-induced damage remains undetermined. In this review, we shall examine evidence in support of the interplay between spatially and/or temporally related environmentally relevant stressors. In vitro or animal-based studies as well as epidemiological surveys have generally examined the combined action of no more than a couple of known or potentially DNA-damaging agents. Moreover, most existing research mainly focused on short-term effects of combined exposures. Hence, it is important that quantitative research addresses the issue of the possible cooperation between chronic exposure to environmental trace contaminants and exposure to EMFs, examining not only the modulation of damage acutely induced by IR but also long-term genome stability.
Growing Interpretable Part Graphs on ConvNets via Multi-Shot Learning

This paper proposes a learning strategy that extracts objectpart concepts from a pre-trained convolutional neural network (CNN), in an attempt to 1) explore explicit semantics hidden in CNN units and 2) gradually grow a semantically interpretable graphical model on the pre-trained CNN for hierarchical object understanding. Given part annotations on very few (e.g. 3–12) objects, our method mines certain latent patterns from the pre-trained CNN and associates them with different semantic parts. We use a four-layer And-Or graph to organize the mined latent patterns, so as to clarify their internal semantic hierarchy. Our method is guided by a small number of part annotations, and it achieves superior performance (about 13%–107% improvement) in part center prediction on the PASCAL VOC and ImageNet datasets.
A Comparative Biomechanical Analysis of Stand Alone Versus Facet Screw and Pedicle Screw Augmented Lateral Interbody Arthrodesis: An In Vitro Human Cadaveric Model.

STUDY DESIGN
Cadaveric biomechanical study.


OBJECTIVE
To investigate the kinematic response of a stand-alone lateral lumbar interbody cage compared with supplemental posterior fixation with either facet or pedicle screws after lateral discectomy.


SUMMARY OF BACKGROUND DATA
Lateral interbody fusion is a promising minimally invasive fixation technique for lumbar interbody arthrodesis. The biomechanical stability of stand-alone cage placement compared with supplemental posterior fixation with either facet or bilateral pedicle screws remains unclear.


METHODS
A 6-degree of freedom spine simulator was used to test flexibility in 7 human cadaveric specimens. Flexion-extension, lateral-bending, and axial-rotation were tested in the intact condition, followed by destabilization through a lateral discectomy at L2-L3 and L4-L5. Specimens were then reconstructed at both operative segments in the following sequence: (1) lateral interbody cage placement; (2) either Discovery facet screws or the Viper F2 system using a transfacet-pedicular trajectory randomized to L2-L3 or L4-L5; and (3) removal of facet screw fixation followed by placement of bilateral pedicle screw instrumentation. Acute range of motion (ROM) was quantified and analyzed.


RESULTS
All 4 reconstruction groups, including stand-alone interbody cage placement, bilateral Discovery facet screws, the Viper F2 system, and bilateral pedicle screw-rod stabilization, resulted in a significant decrease in acute ROM in all loading modes tested (P<0.05). There were no significant differences observed between the 4 instrumentation groups (P>0.05). Although not statistically significant, the Viper F2 system resulted in greatest reduction of acute ROM in both flexion-extension and axial rotation versus all other treatments (P>0.05).


CONCLUSIONS
Stand-alone interbody cage placement results in a significant reduction in acute ROM at the operative segment in the absence of posterior supplemental fixation. If added fixation is desired, facet screw placement, including the Viper F2 facet screw system using an integrated compression washer and transfacet-pedicular trajectory, provides similar acute stability to the spinal segment compared with traditional bilateral pedicle screw fixation in the setting of lateral interbody cage deployment.
Ambulatory Care for Constipation in the United States, 1993–2004

OBJECTIVES:Chronic constipation is one of the most common disorders seen in primary care. In order to examine longitudinal changes in the ambulatory care that occur in constipation evaluation and management, we examined national trends in physician office visits associated with constipation between 1993 and 2004.METHODS:Data were derived from the National Ambulatory Medical Care Survey (NAMCS) and the National Hospital Ambulatory Care Survey (NHAMCS) for 1993–2004. Patient visits were classified as encounters for constipation-related care. Analyses were performed by combining 4 yr of data (1993–1996, 1997–2000, and 2001–2004).RESULTS:Ambulatory visits for constipation increased from 4 million (95% CI 3.3–4.7 million) ambulatory visits for constipation annually during 1993–1996 period to 7.95 million (95% CI 6.6–9.4 million) visits during the 2001–2004 period. The proportion of medical visits for constipation increased for pediatricians, but decreased for adult primary care providers from 1993 to 2004. During the observed time period, the proportion of medical visits for constipation did not change for gastroenterologists. The primary treatment for constipation shifted from bulking agents (fiber) to osmotic laxatives.CONCLUSION:There has been a significant increase in physician office visits for constipation between 1993 and 2004, with the highest rate of increase in the pediatric population. Longitudinal trends indicate an increase in constipation-related visits for pediatricians. The primary treatment for constipation among medical providers shifted from using bulking agents to osmotic laxatives for unknown reasons.
Clinical utility of dopamine transporter single photon emission CT (DaT-SPECT) with (123I) ioflupane in diagnosis of parkinsonian syndromes

The diagnosis of movement disorders including Parkinson's disease (PD) and essential tremor is determined through clinical assessment. The difficulty with diagnosis of early PD has been highlighted in several recent clinical trials. Studies have suggested relatively high clinical diagnostic error rates for PD and essential tremor. This review was undertaken to clarify the utility of DaT-SPECT imaging with ((123)I)ioflupane (DaTSCAN or DaTscan or ((123)I)FP-CIT) in assisting practitioners in their clinical decision making by visualising the dopamine transporter in parkinsonian cases. In some patients with suspected parkinsonian syndromes, SPECT imaging with ((123)I)ioflupane is useful to assist in the diagnosis and to help guide prognosis and treatment decisions, including avoiding medications that are unlikely to provide benefit. Clinicians ordering ((123)I)ioflupane SPECT should be aware of its limitations and pitfalls and should order scans when there is diagnostic uncertainty or when the scan will be helpful in clinical decision making.
Functional thumb orthosis for type I and II boutonniere deformity on the dominant hand in patients with rheumatoid arthritis: a randomized controlled study.

OBJECTIVE
To evaluate the effectiveness of a functional thumb orthosis on the dominant hand of patients with rheumatoid arthritis and boutonniere thumb.


METHODS
Forty patients with rheumatoid arthritis and boutonniere deformity of the thumb were randomly distributed into two groups. The intervention group used the orthosis daily and the control group used the orthosis only during the evaluation. Participants were evaluated at baseline as well as after 45 and 90 days. Assessments were preformed using the O'Connor Dexterity Test, Jamar dynamometer, pinch gauge, goniometry and the Health Assessment Questionnaire. A visual analogue scale was used to assess thumb pain in the metacarpophalangeal joint.


RESULTS
Patients in the intervention group experienced a statistically significant reduction in pain. The thumb orthosis did not disrupt grip and pinch strength, function, Health Assessment Questionnaire score or dexterity in either group.


CONCLUSION
The use of thumb orthosis for type I and type II boutonniere deformities was effective in relieving pain.
THREE PHASE INDUCTION MOTOR DRIVE USING IGBTs AND CONSTANT V/F METHOD

This paper presents design and analysis of a three phase induction motor drive using IGBT‟s at the inverter power stage with volts hertz control (V/F) in closed loop using dsPIC30F2010 as a controller. It is a 16 bit high-performance digital signal controller (DSC). DSC is a single chip embedded controller that integrates the controller attributes of a microcontroller with the computation and throughput capabilities of a DSP in a single core. A 1HP, 3-phase, 415V, 50Hz induction motor is used as load for the inverter. Digital Storage Oscilloscope Textronix TDS2024B is used to record and analyze the various waveforms. The experimental results for V/F control of 3Phase induction motor using dsPIC30F2010 chip clearly shows constant volts per hertz and stable inverter line to line output voltage. Keywords--DSC, constant volts per hertz, PWM inverter, ACIM.
The Health Anxiety Inventory: development and validation of scales for the measurement of health anxiety and hypochondriasis.

BACKGROUND
A self-rated measure of health anxiety should be sensitive across the full range of intensity (from mild concern to frank hypochondriasis) and should differentiate people suffering from health anxiety from those who have actual physical illness but who are not excessively concerned about their health. It should also encompass the full range of clinical symptoms characteristic of clinical hypochondriasis. The development and validation of such a scale is described.


METHOD
Three studies were conducted. First, the questionnaire was validated by comparing the responses of patients suffering from hypochondriasis with those suffering from hypochondriasis and panic disorder, panic disorder, social phobia and non-patient controls. Secondly, a state version of the questionnaire was administered to patients undergoing cognitive-behavioural treatment or wait-list in order to examine the measure's sensitivity to change. In the third study, a shortened version was developed and validated in similar types of sample, and in a range of samples of people seeking medical help for physical illness.


RESULTS
The scale was found to be reliable and to have a high internal consistency. Hypochondriacal patients scored significantly higher than anxiety disorder patients, including both social phobic patients and panic disorder patients as well as normal controls. In the second study, a 'state' version of the scale was found to be sensitive to treatment effects, and to correlate very highly with a clinician rating based on an interview of present clinical state. A development and refinement of the scale (intended to reflect more fully the range of symptoms of and reactions to hypochondriasis) was found to be reliable and valid. A very short (14 item) version of the scale was found to have comparable properties to the full length scale.


CONCLUSIONS
The HAI is a reliable and valid measure of health anxiety. It is likely to be useful as a brief screening instrument, as there is a short form which correlates highly with the longer version.
The effect of treatment with antipsychotic drugs on brain N-acetylaspartate measures in patients with schizophrenia.

BACKGROUND
The specific intracellular effects of antipsychotic drugs are largely unknown. Studies in animals have suggested that antipsychotics modify the expression of various intraneuronal proteins, but no analogous in vivo data in humans are available. The objective of the present study was to assess whether antipsychotics modify N-acetylaspartate (an intraneuronal marker of neuronal functional integrity) measures in brains of patients with schizophrenia.


METHODS
We used proton magnetic resonance spectroscopic imaging to study 23 patients with schizophrenia (DSM-IV diagnosis) using a within-subject design. Patients were studied twice: once while on a stable regimen of antipsychotic drug treatment (for at least 4 weeks) and once while off medication for at least 2 weeks. Several cortical and subcortical regions were assessed, including the dorsolateral prefrontal cortex and the hippocampal area.


RESULTS
Analysis of variance showed that, while on antipsychotics, patients had significantly higher N-acetylaspartate measures in the dorsolateral prefrontal cortex (p =.002). No other region showed any significant effect of treatment.


CONCLUSIONS
These results indicate that antipsychotic drugs increase N-acetylaspartate measures selectively in the dorsolateral prefrontal cortices of patients with schizophrenia, suggesting that these drugs modify in a regionally specific manner the function of a population of cortical neurons. N-Acetylaspartate measures may provide a useful tool to further investigate the effects of antipsychotics at the intracellular level.
Socio-technical systems: From design methods to systems engineering

It is widely acknowledged that adopting a socio-technical approach to system development leads to systems that are more acceptable to end users and deliver better value to stakeholders. Despite this, such approaches are not widely practised. We analyse the reasons for this, highlighting some of the problems with the better known socio-technical design methods. Based on this analysis we propose a new pragmatic framework for socio-technical systems engineering (STSE) which builds on the (largely independent) research of groups investigating work design, information systems, computersupported cooperative work, and cognitive systems engineering. STSE bridges the traditional gap between organisational change and system development using two main types of activity: sensitisation and awareness; and constructive engagement. From the framework, we identify an initial set of interdisciplinary research problems that address how to apply socio-technical approaches in a cost-effective way, and how to facilitate the integration of STSE with existing systems and software engineering approaches.
The Intensity Distribution of Electric Field Radiating from the High Power Pulsed Electromagnetic Wave Generator with Water Gap Switch and Water Capacitor

Nanosecond and sub-nanosecond high voltage pulses can provide new applications. A cancer treatment by an ultra-short pulse high electric field is one of them. High power pulsed electromagnetic wave has been proposed to apply the high electric field for that treatment. This work focuses on the design of a compact high power pulsed electromagnetic wave generator using a nanosecond pulse power generator for the cancer treatment. We employed a L-C inversion circuit for the pulsed power generator to obtain a voltage waveform with a single frequency for applying an antenna. A water gap switch and a water capacitor were used for L-C inversion circuit to obtain the frequency of hundreds MHz, because the water gap switch has a low inductance property and the loop inductance of the circuit can be made small using the same medium for the capacitor and the switch. By using the water gap switch and the water capacitor for the L-C inversion circuit, the pulsed voltage had the frequency element of 250 MHz. The electromagnetic wave was radiated underwater by the loop antenna in this experiment. A focusing bowl was equipped on the radiating antenna to obtain higher electric field. The intensity distribution of electric field focusing by the focusing bowl was measured at 6.6 kV of applying voltage to the radiating antenna. The peak electric field intensity is 11.3 kV/cm at a focal point. The area of the electric field intensity over 10.
March Madness and the Office Pool

March brings March Madness, the annual conclusion to the U.S. men’s college basketball season with two single elimination basketball tournaments showcasing the best college teams in the country. Almost as mad is the plethora of office pools across the country where the object is to pick a priori as many game winners as possible in the tournament. More generally, the object in an office pool is to maximize total pool points, where different points are awarded for different correct winning predictions. We consider the structure of single elimination tournaments, and show how to efficiently calculate the mean and the variance of the number of correctly predicted wins (or more generally the total points earned in an office pool) for a given slate of predicted winners. We apply these results to both random and Markov tournaments. We then show how to determine optimal office pool predictions that maximize the expected number of points earned in the pool. Considering various Markov probability models for predicting game winners based on regular season performance, professional sports rankings, and Las Vegas betting odds, we compare our predictions with what actually happened in past NCAA and NIT tournaments. These models perform similarly, achieving overall prediction accuracies of about 58%, but do not surpass the simple strategy of picking the seeds when the goal is to pick as many game winners as possible. For a more sophisticated point structure, however, our models do outperform the strategy of picking the seeds. (March Madness; Office Pools; Probability Modeling; Statistical Estimation; Markov Models; Dynamic Programming )
A knowledge-based simulation environment for hierarchical flexible manufacturing

This article presents an approach to embedding expert systems within an object oriented simulation environment. The basic idea is to create classes of expert system models that can be interfaced with other model classes. An expert system shell is developed within a knowledge-based design and simulation environment which combines artificial intelligence and systems modeling concepts. In the given framework, interruptible and distributed expert systems can be defined as components of simulations models. This facilitates simulation modeling of knowledge-based controls for flexible manufacturing and many other autonomous intelligent systems. Moreover, the structure of a system can be specified using a recursive system entity structure (SES) and unfolded to generate a family of hierarchical structures using an extension of SES pruning called recursive pruning. This recursive generation of hierarchical structures is especially appropriate for design of multilevel flexible factories. The article illustrates the utility of the proposed framework within the flexible manufacturing context.