LLukas22/scidocs huggingface dataset:
MIB1 expression in basal cell layer: a diagnostic tool to identify premalignancies of the vulva

Lichen sclerosus, high-grade usual vulvar intraepithelial neoplasia (VIN) and differentiated VIN have a different malignant potential. The objective of this study was to quantify the proliferative activity in the basal region of the epithelium of vulvar premalignancies. Furthermore, we investigated whether MIB1 expression in the basal region of vulvar epithelium can be helpful in diagnosing differentiated VIN, which may be hard to discern from normal epithelium. MIB1 was used to immunohistochemically visualise proliferating cells within formalin-fixed, paraffin-embedded, archival tissue sections of different vulvar premalignancies (N=48) and normal vulvar epithelium (N=16). Automatic digital image analysis software was developed to quantify the proliferating fraction in different parts of the epithelium (MIB1 positivity index). MIB1 expression differed among the various vulvar premalignancies; a MIB1-negative basal cell layer was a distinct feature of normal vulvar epithelium. No MIB1-negative basal cell layer was noted in differentiated VIN or other vulvar premalignancies. Owing to this negative cell layer, the MIB1 proliferation index in normal vulvar epithelium was significantly lower than in vulvar premalignancies. In conclusion, MIB1 expression can be a helpful tool in diagnosing a premalignancy and has additional value especially to distinguish differentiated VIN neoplasia from normal vulvar epithelium, but cannot explain the differences in malignant potential.
COMMUTATIVE MONADS AS A THEORY OF DISTRIBUTIONS

It is shown how the theory of commutative monads provides an axiomatic framework for several aspects of distribution theory in a broad sense, including proba- bility distributions, physical extensive quantities, and Schwartz distributions of compact support. Among the particular aspects considered here are the notions of convolution, density, expectation, and conditional probability.
Competitor Identification and Competitor Analysis : A Broad-Based Managerial Approach

Managerial myopia in identifying competitive threats is a well-recognized phenomenon (Levitt, 1960; Zajac and Bazerman, 1991). Identifying such threats is particularly problematic, since they may arise from substitutability on the supply side as well as on the demand side. Managers who focus only on the product market arena in scanning their competitive environment may fail to notice threats that are developing due to the resources and latent capabilities of indirect or potential competitors. This paper brings together insights from the fields of strategic management and marketing to develop a simple but powerful set of tools for helping managers overcome this common problem. We present a two-stage framework for competitor identification and analysis that brings into consideration a broad range of competitors, including potential competitors, substitutors, and indirect competitors. Specifically we draw from Peteraf and Bergen’s (2001) framework for competitor identification to develop a hierarchy of competitor awareness. That is used, in combination with resource equivalence, to generate hypotheses on competitive analysis. This framework not only extends the ken of managers, but also facilitates an assessment of the strategic opportunities and threats that various competitors represent and allows managers to assess their significance in relative terms. Copyright # 2002 John Wiley & Sons, Ltd.
Why do people play mobile social games? An examination of network externalities and of uses and gratifications

Purpose – The purpose of this paper is to identify the factors that influence people to play socially interactive games on mobile devices. Based on network externalities and theory of uses and gratifications (U&G), it seeks to provide direction for further academic research on this timely topic. Design/methodology/approach – Based on 237 valid responses collected from online questionnaires, structural equation modeling technology was employed to examine the research model. Findings – The results reveal that both network externalities and individual gratifications significantly influence the intention to play social games on mobile devices. Time flexibility, however, which is one of the mobile device features, appears to contribute relatively little to the intention to play mobile social games. Originality/value – This research successfully applies a combination of network externalities theory and U&G theory to investigate the antecedents of players’ intentions to play mobile social games. This study is able to provide a better understanding of how two dimensions – perceived number of users/peers and individual gratification – influence mobile game playing, an insight that has not been examined previously in the mobile apps literature.
Treatment of Knee Osteoarthritis in Relation to Hamstring and Quadriceps
Strength

[Purpose] To assess the effect of hamstring and quadriceps strengthening exercises on pain intensity, gait velocity, maximum isometric strength, and activities of daily living of patients with knee osteoarthritis (OA). [Subjects and Methods] A total of 20 patients with knee OA, 50 to 65 years of age (57.65 ± 4.78 years), received hot packs, strengthening exercises for the quadriceps and the hamstring muscles and stretching exercises for hamstring muscles. Outcome measures included: the Western Ontario and McMaster Universities OA index questionnaire (WOMAC) scores for assessing health status and health outcomes of knee OA; self-reported pain intensity scores, measured using a visual analogue scale; the 50 ft walk test (a measure of gait velocity and function); and handheld dynamometry (a tool used to measure maximum isometric strength of knee extension and flexion). [Results] There was a significant difference between pre- and post-intervention measures of pain intensity, 50 ft walk times, hamstring strength, and quadriceps strength. Significant differences in WOMAC measures were also observed in the subscales of pain, stiffness and physical function, as well as WOMAC total scores. [Conclusion] Strengthening the hamstring muscles in addition to strengthening the quadriceps muscles proved to be beneficial for perceived knee pain, range of motion, and decreasing the limitation of functional performance of patients with knee OA.
A Note on Boolos' Proof of the Incompleteness Theorem

We give a proof of Godel's first incompleteness theorem based on Berry's paradox, and from it we also derive the second incompleteness theorem model-theoretically. 
 
 
 
Mathematics Subject Classification: 03F30.
Memristor-based devices for sensing

In this paper we propose CMOS-compatible Memristive-Biosensors as label-free, highly sensitive sensors for in-air detection of Vascular Endothelial Growth Factor (VEGF) molecules. The memristive behavior of the fabricated devices is strongly affected by molecules in proximity of the wire surface. In this paper, we demonstrate the reproducibility of the measurement based on the memristive voltage gap. We also show the successful sensing of femto-molar amounts of VEGF. Specifically, we demonstrate a correlation between the decreasing behavior of the voltage gap and the increasing concentrations of VEGF. The voltage gap dependence on the pH of the initial solution is also shown as a further proof of the ionic interactions occurring at the SiNW surface. All measurements are performed in air, under controlled humidity; this makes our approach more sensitive thanks to the lowered Debye screening effect of counterions.
Does the Market Respond to an Endorsement of Social Responsibility? The Role of Institutions, Information, and Legitimacy

A consensus has emerged in the burgeoning literature on corporate social responsibility (CSR) that “virtuous” firms are often rewarded by the marketplace. Unfortunately, the mechanisms through which those rewards materialize are not well understood. Furthermore, it is difficult for managers and investors to know whether a company is actually engaged in responsible behavior. Thus, many stakeholders rely on institutional assessments of a firm’s social practices to inform their own judgments about that company’s CSR reputation. In this article, we draw on institutional theory and research on reputation and legitimacy to investigate the relationship between institutional endorsements (and repudiation) of CSR and firm financial performance. Our empirical results indicate that institutional intermediaries influence market assessments of a firm’s social responsibility and highlight the importance of the legitimacy-conferring function of expert bodies in understanding the relationship between social and financial performance. Our findings also illustrate the delicate interplay among different social performance assessments, reputation, and measures of financial and operating performance such that operating
A practical guide to Basic Statistical Techniques for Data Analysis in Cosmology

This is the summary of 4 Lectures given at the XIX Canary islands winter school of Astrophysics ''The Cosmic Microwave Background, from Quantum Fluctuations to the present Universe''. Lectures were intended for master/beginning PhD students in cosmology.
Effect of coronary dominance on 2-year outcomes after percutaneous coronary intervention in patients with acute coronary syndrome.

OBJECTIVES
This retrospective, single-center, observational analysis from prospectively collected database evaluated whether left dominance affected the long-term outcomes of acute coronary syndrome patients undergoing percutaneous coronary intervention, and whether the effect was independent of SYNTAX score.


BACKGROUND
Left dominance is believed to be associated with worse prognoses. The anatomical SYNTAX score is a scoring system based on the complexity and severity of coronary lesions and is thought to be a prognostic tool to predict short- and long-term outcomes. There are few studies about whether the effect of left dominance is independent of SYNTAX score.


METHODS
Between January 2013 and December 2013, 6255 consecutive acute coronary syndrome patients who were admitted to Fuwai hospital and underwent percutaneous coronary intervention (PCI) were enrolled in this study. Based on coronary dominance and the calculation methods of the SYNTAX score, patients were divided into a left-dominant group (LD group; 390 patients) and a right-dominant or co-dominant group (RD + Co group, 5865 patients).


RESULT
The 2-year mortality rate was significantly higher in the LD group than in the RD + Co group (2.58% vs. 1.23%, P = 0.024). In multivariate Cox analysis, the independent predictors of mortality were coronary dominance, IABP support, age, baseline SYNTAX score, and ejection fraction.


CONCLUSIONS
LD was an independent predictor of long-term mortality in ACS patients undergoing PCI. The effect of LD still existed after adjustment for several important variables and was independent of SYNTAX score. © 2017 Wiley Periodicals, Inc.
DSP-based speed adaptive flux observer of induction motor

A method of estimating the speed of an induction motor is presented. This method is based on the adaptive control theory. Experimental results of a direct field oriented induction motor control without speed sensors are presented.<<ETX>>
Compactions in Apache Cassandra : Performance Analysis of Compaction Strategies in Apache Cassandra

Context. The global communication system is in a tremendous growth, leading to wide range of data generation. The Telecom operators in various Telecom Industries, that generate large amount of data has a need to manage these data efficiently. As the technology involved in the database management systems is increasing, there is a remarkable growth of NoSQL databases in the 20 century. Apache Cassandra is an advanced NoSQL database system, which is popular for handling semi-structured and unstructured format of Big Data. Cassandra has an effective way of compressing data by using different compaction strategies. This research is focused on analyzing the performances of different compaction strategies in different use cases for default Cassandra stress model. The analysis can suggest better usage of compaction strategies in Cassandra, for a write heavy workload. Objectives. In this study, we investigate the appropriate performance metrics to evaluate the performance of compaction strategies. We provide the detailed analysis of Size Tiered Compaction Strategy, Date Tiered Compaction Strategy, and Leveled Compaction Strategy for a write heavy (90/10) work load, using default cassandra stress tool. Methods. A detailed literature research has been conducted to study the NoSQL databases, and the working of different compaction strategies in Apache Cassandra. The performances metrics are considered by the understanding of the literature research conducted, and considering the opinions of supervisors and Ericsson’s Apache Cassandra team. Two different tools were developed for collecting the performances of the considered metrics. The first tool was developed using Jython scripting language to collect the cassandra metrics, and the second tool was developed using python scripting language to collect the Operating System metrics. The graphs have been generated in Microsoft Excel, using the values obtained from the scripts. Results. Date Tiered Compaction Strategy and Size Tiered Compaction strategy showed more or less similar behaviour during the stress tests conducted. Level Tiered Compaction strategy has showed some remarkable results that effected the system performance, as compared to date tiered compaction and size tiered compaction strategies. Date tiered compaction strategy does not perform well for default cassandra stress model. Size tiered compaction can be preferred for default cassandra stress model, but not considerable for big data. Conclusions. With a detailed analysis and logical comparison of metrics, we finally conclude that Level Tiered Compaction Strategy performs better for a write heavy (90/10) workload while using default cassandra stress model, as compared to size tiered compaction and date tiered compaction strategies.
Solid state amorphization of metastable Al0.5TiZrPdCuNi high entropy alloy investigated by high voltage electron microscopy

Abstract The phase stability of high entropy alloy (HEA), Al 0.5 TiZrPdCuNi, under fast electron irradiation was studied by in-situ high voltage electron microscopy (HVEM). The initial phase of this alloy quenched from the melt was dependent on cooling rate. At high cooling rates an amorphous phase was obtained, whereas a body-centered cubic ( b.c.c. ) phase were obtained at low cooling rates. By thermal crystallization of the amorphous phase b.c.c. phase nano-crystals were formed. Upon fast electron irradiation solid state amorphization (SSA) was observed in b.c.c. phase regardless of the initial microstructure (i.e., “coarse crystalline structure” or “nano-crystalline structure with grain boundaries as a sink for point defects”). SSA behavior in the Al 0.5 TiZrPdCuNi HEAs was investigated by in-situ transmission electron microscopy observations. Because the amorphization is very rarely achieved in a solid solution phase under fast electron irradiation in common metallic materials, this result suggests that the Al 0.5 TiZrPdCuNi HEA from other common alloys and the other HEAs. The differences in phase stability against the irradiation between the Al 0.5 TiZrPdCuNi HEA and the other HEAs were discussed. This is the first experimental evidence of SSA in HEAs stimulated by fast electron irradiation.
Docetaxel in combination with mitoxantrone and granulocyte colony-stimulating factor as front-line chemotherapy in metastatic breast cancer: a multicenter phase II study.

PURPOSE
To evaluate the activity and tolerance of docetaxel in combination with mitoxantrone and granulocyte colony-stimulating factor (G-CSF) as front-line treatment in patients with metastatic breast cancer (MBC).


PATIENTS AND METHODS
Fifty-four previously untreated patients with MBC who had bidimensionally measurable disease were enrolled onto the study. Forty-eight (89%) patients had visceral metastases and nineteen (36%) had relapsed within twelve months following adjuvant chemotherapy. Docetaxel (100 mg/m2) was given on day 1 after appropriate premedication and mitoxantrone (20 mg/m2) on day 8. G-CSF (150 mcg/m2/d s.c.) was administered from day 2 to day 6 and from day 9 to day 15. The regimen was repeated every three weeks, on an outpatient basis.


RESULTS
In an intention-to-treat analysis, 9 (17%) CRs, 24 (44%) PRs, (overall response rate 61%; 95% confidence interval (CI): 48.1%-74.1%), 12 (22%) SD and 9 (17%) PD were observed. The median duration of response and the median time to tumor progression was 12.5 and 14 months, respectively. The overall median survival was 16.5 months, whilst the probability for one- and three-year survival was 61% and 35%, respectively. Grade 3-4 neutropenia occurred in 37 (69%) patients, and febrile neutropenia in 16 (30%); there was one death due to sepsis. Grade 3-4 thrombocytopenia occurred in four (8%) patients. Grade 2-3 neurosensory toxicity was observed in 8 (15%) patients and grade 2-3 asthenia in 24 (45%).


CONCLUSIONS
Docetaxel in combination with mitoxantrone and G-CSF support is an intensified and active front-line regimen for patients with MBC; despite its hematological toxicity, this regimen merits further comparison with other standard anthracycline- and/or taxane-based combinations.
The New Revolution in Economics

In this section, Capital & Class carries contributions which address contemporary themes of concern to the left. It is our intention that contributions provoke controversy, challenge taken-for-granted assumptions and raise themes and issues of concern to readers of Capital & Class in an unusual manner.
A pipeline architecture for computing the Euler number of a binary image

Euler number of a binary image is a fundamental topological feature that remains invariant under translation, rotation, scaling, and rubber-sheet transformation of the image. In this work, a run-based method for computing Euler number is formulated and a new hardware implementation is described. Analysis of time complexity and performance measure is provided to demonstrate the efficiency of the method. The sequential version of the proposed algorithm requires significantly fewer number of pixel accesses compared to the existing methods and tools based on bit-quad counting or quad-tree, both for the worst case and the average case. A pipelined architecture is designed with a single adder tree to implement the algorithm on-chip by exploiting its inherent parallelism. The architecture uses O(N) 2-input gates and requires O(N logN) time to compute the Euler number of an N · N image. The same hardware, with minor modification, can be used to handle arbitrarily large pixel matrices. A standard cell based VLSI implementation of the architecture is also reported. As Euler number is a widely used parameter, the proposed design can be readily used to save computation time in many image processing applications. 2005 Elsevier B.V. All rights reserved.
A Review on the Impact of Smartphones on Academic Performance of Students in Higher Learning Institutions in Tanzania

Smartphones act as mobile entertainment units where a user can: watch videos, listen to music, update blogs, as well as audio and video blogging. The aim of this study was to review the impact of smartphones on academic performance of students in higher learning institutions. Intensive literature review was done finding out the disadvantages and advantages brought by smartphones in academic arena. In the future, research will be conducted at Ruaha Catholic University to find out whether students are benefiting from using smartphones in their daily studies and whether do they affect their GPA at the end of the year. Keywords— Smartphones, Academic performance, higher learning students, Addictions, GPA, RUCU.
Pilot study: Investigating the effects of Kinesio Taping® on functional activities in children with cerebral palsy.

OBJECTIVE
To investigate the immediate effects of Kinesio Taping® (KT) on sit-to-stand (STS) movement, balance and dynamic postural control in children with cerebral palsy (CP).


METHODS
Four children diagnosed with left hemiplegic CP level I by the Gross Motor Function Classification System were evaluated under conditions without taping as control condition (CC); and with KT as kinesio condition. A motion analysis system was used to measure total duration of STS movement and angular movements of each joint. Clinical instruments such as Pediatric Balance Scale (PBS) and Timed up and Go (TUG) were also applied.


RESULTS
Compared to CC, decreased total duration of STS, lower peak ankle flexion, higher knee extension at the end of STS, and decreased total time in TUG; but no differences were obtained on PBS score in KT.


CONCLUSION
Neuromuscular taping seems to be beneficial on dynamic activities, but not have the same performance in predominantly static activities studied.
A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease

A BSTRACT Background There is evidence that medications or vitamins that increase the levels of brain catecholamines and protect against oxidative damage may reduce the neuronal damage and slow the progression of Alzheimer’s disease. Methods We conducted a double-blind, placebocontrolled, randomized, multicenter trial in patients with Alzheimer’s disease of moderate severity. A total of 341 patients received the selective monoamine oxidase inhibitor selegiline (10 mg a day), alphatocopherol (vitamin E, 2000 IU a day), both selegiline and alpha-tocopherol, or placebo for two years. The primary outcome was the time to the occurrence of any of the following: death, institutionalization, loss of the ability to perform basic activities of daily living, or severe dementia (defined as a Clinical Dementia Rating of 3). Results Despite random assignment, the baseline score on the Mini–Mental State Examination was higher in the placebo group than in the other three groups, and this variable was highly predictive of the primary outcome (P 0.001). In the unadjusted analyses, there was no statistically significant difference in the outcomes among the four groups. In analyses that included the base-line score on the Mini–Mental State Examination as a covariate, there were significant delays in the time to the primary outcome for the patients treated with selegiline (median time, 655 days; P 0.012), alpha-tocopherol (670 days, P 0.001), or combination therapy (585 days, P 0.049), as compared with the placebo group (440 days). Conclusions In patients with moderately severe impairment from Alzheimer’s disease, treatment with selegiline or alpha-tocopherol slows the progression of disease. (N Engl J Med 1997;336:1216-22.)
Facts come first with work injuries.

Review the necessary actions for a prompt and thorough investigation of claimed work accidents.