LLukas22/scidocs huggingface dataset:
Incremental diagnostic value of preoperative 99mTc-MIBI SPECT in patients with a parathyroid adenoma.

UNLABELLED
The purpose of this prospective study was to evaluate the diagnostic value of early parathyroid SPECT combined with quantitative analysis as compared with planar imaging in patients undergoing minimally invasive radioguided surgery.


METHODS
A total of 52 consecutive patients with primary hyperparathyroidism underwent planar and SPECT parathyroid scintigraphy 2-5 d before surgery. Each patient had a single-tracer dual-phase technique using (99m)Tc-methoxyisobutylisonitrile ((99m)Tc-MIBI) and a double-tracer subtraction technique using a delayed (99m)Tc-pertechnetate scan. Immediately after the first (99m)Tc-MIBI planar image, a SPECT study was acquired. Before radioguided parathyroidectomy, each patient was reinjected with (99m)Tc-MIBI. Serum calcium levels were available for all patents before surgery and at 8 and 24 h after surgery. Serum parathyroid hormone (PTH) levels were also available for all patients. Quantitative analysis was performed using the average count ratio of parathyroid to left thyroid lobe, right thyroid lobe, and maximum thyroid activity. All patients had histopathologic examination of the removed glands.


RESULTS
The average time for radioguided surgery was 30 min (range, 20-40 min). Postsurgical calcium levels correlated significantly with the adenoma weight (r = 0.5; P = 0.016). Combined planar scintigraphy correctly identified 41 adenomas (79%). SPECT increased the sensitivity to 96%. SPECT was superior to planar imaging in 9 patients, mainly in patients with ectopic adenomas or with multinodular goiters. Gland size did not affect significantly the detectability of SPECT. (99m)Tc-MIBI retention was noted in only 31 adenomas (60%). The average uptake ratios of parathyroid counts to the left lobe, right lobe, and maximum thyroid activity were 1.20 +/- 0.42, 1.29 +/- 0.45, and 0.84 +/- 0.35, respectively. The latter ratio was significantly correlated with PTH levels before surgery (r = 0.408; P = 0.04).


CONCLUSION
Our data indicate that early preoperative SPECT in patients with primary hyperparathyroidism is essential for accurate localization of parathyroid adenomas and for the selection of patients who are candidates for minimally invasive radioguided surgery. Planar parathyroid imaging is less sensitive compared with SPECT, and washout kinetics of (99m)Tc-MIBI are unreliable in the dual-phase technique. Patients with higher presurgical PTH levels may especially benefit from radioguided surgery.
mHealth Technologies to Influence Physical Activity and Sedentary Behaviors: Behavior Change Techniques, Systematic Review and Meta-Analysis of Randomized Controlled Trials.

BACKGROUND
mHealth programs offer potential for practical and cost-effective delivery of interventions capable of reaching many individuals.


PURPOSE
To (1) compare the effectiveness of mHealth interventions to promote physical activity (PA) and reduce sedentary behavior (SB) in free-living young people and adults with a comparator exposed to usual care/minimal intervention; (2) determine whether, and to what extent, such interventions affect PA and SB levels and (3) use the taxonomy of behavior change techniques (BCTs) to describe intervention characteristics.


METHODS
A systematic review and meta-analysis following PRISMA guidelines was undertaken to identify randomized controlled trials (RCTs) comparing mHealth interventions with usual or minimal care among individuals free from conditions that could limit PA. Total PA, moderate-to-vigorous intensity physical activity (MVPA), walking and SB outcomes were extracted. Intervention content was independently coded following the 93-item taxonomy of BCTs.


RESULTS
Twenty-one RCTs (1701 participants-700 with objectively measured PA) met eligibility criteria. SB decreased more following mHealth interventions than after usual care (standardised mean difference (SMD) -0.26, 95 % confidence interval (CI) -0.53 to -0.00). Summary effects across studies were small to moderate and non-significant for total PA (SMD 0.14, 95 % CI -0.12 to 0.41); MVPA (SMD 0.37, 95 % CI -0.03 to 0.77); and walking (SMD 0.14, 95 % CI -0.01 to 0.29). BCTs were employed more frequently in intervention (mean = 6.9, range 2 to 12) than in comparator conditions (mean = 3.1, range 0 to 10). Of all BCTs, only 31 were employed in intervention conditions.


CONCLUSIONS
Current mHealth interventions have small effects on PA/SB. Technological advancements will enable more comprehensive, interactive and responsive intervention delivery. Future mHealth PA studies should ensure that all the active ingredients of the intervention are reported in sufficient detail.
Plagiarism Detection Using the Levenshtein Distance and Smith-Waterman Algorithm

Plagiarism in texts is issues of increasing concern to the academic community. Now most common text plagiarism occurs by making a variety of minor alterations that include the insertion, deletion, or substitution of words. Such simple changes, however, require excessive string comparisons. In this paper, we present a hybrid plagiarism detection method. We investigate the use of a diagonal line, which is derived from Levenshtein distance, and simplified Smith-Waterman algorithm that is a classical tool in the identification and quantification of local similarities in biological sequences, with a view to the application in the plagiarism detection. Our approach avoids globally involved string comparisons and considers psychological factors, which can yield significant speed-up by experiment results. Based on the results, we indicate the practicality of such improvement using Levenshtein distance and Smith-Waterman algorithm and to illustrate the efficiency gains. In the future, it would be interesting to explore appropriate heuristics in the area of text comparison.
Vehicle routing with multiple deliverymen: Modeling and heuristic approaches for the VRPTW

0377-2217/$ see front matter 2011 Elsevier B.V. A doi:10.1016/j.ejor.2011.12.005 ⇑ Corresponding author. Fax: +55 16 33518240. E-mail addresses: vpureza@dep.ufscar.br (V. (R. Morabito), marc.reimann@uni-graz.at (M. Reiman In real life distribution of goods, relatively long service times may make it difficult to serve all requests during regular working hours. These difficulties are even greater if the beginning of the service in each demand site must occur within a time window and violations of routing time restrictions are particularly undesirable. We address this situation by considering a variant of the vehicle routing problem with time windows for which, besides routing and scheduling decisions, a number of extra deliverymen can be assigned to each route in order to reduce service times. This problem appears, for example, in the distribution of beverage and tobacco in highly dense Brazilian urban areas. We present a mathematical programming formulation for the problem, as well as a tabu search and an ant colony optimization heuristics for obtaining minimum cost routes. The performance of the model and the heuristic approaches are evaluated using instances generated from a set of classic examples from the literature. 2011 Elsevier B.V. All rights reserved.
Is sexual risk taking behaviour changing in rural south-west Uganda? Behaviour trends in a rural population cohort 1993–2006

OBJECTIVE
To describe sexual behaviour trends in a rural Ugandan cohort in the context of an evolving HIV epidemic, 1993-2006.


METHODS
Sexual behaviour data were collected annually from a population cohort in which HIV serological surveys were also conducted. Behaviour trends were determined using survival analysis and logistic regression. Trends are reported based on the years in which the respective indicators were collected.


RESULTS
Between 1993 and 2006, median age at first sex increased from 16.7 years to 18.2 years among 17-20-year-old girls and from 18.5 years to 19.9 years among boys. Both sexes reported a dip in age at sexual debut between 1998 and 2001. One or more casual partners in the past 12 months among men rose from 11.6% in 1997 to 12.7% in 2004 and then declined to 10.2% in 2006. Among women it increased from 1.4% in 1997 to 3.7% in 2004 and then reduced to 1.4% in 2006. The rise in casual partners between 1997 and 2004 was driven mainly by older age groups. Trends in condom use with casual partners varied by age, increasing among those aged 35+ years, declining in the middle age groups and presenting a dip and then a rise in the youngest aged group (13-19 years).


CONCLUSION
Among youth, risky behaviour declined but increased in the late 1990s/early 2000s. Among those aged 35+ years, condom use rose but casual partners also rose. Several indicators portrayed a temporary increase in risk taking behaviour from 1998 to 2002.
Structural and Functional Progression in the Early Manifest Glaucoma Trial.

PURPOSE
To elucidate the temporal relationship between detection of glaucomatous optic disc progression, as assessed by fundus photography, and visual field progression.


DESIGN
Prospective, randomized, longitudinal trial.


PARTICIPANTS
Three hundred six study eyes with manifest glaucoma with field loss and 192 fellow eyes without any field defect at the start of the trial, from a total of 249 subjects included in the Early Manifest Glaucoma Trial (EMGT), were assessed.


METHODS
Evaluation of visual field progression and optic disc progression during an 8-year follow-up period. Three graders independently assessed optic disc progression in optic disc photographs. Visual field progression was assessed using glaucoma change probability maps and the EMGT progression criterion.


MAIN OUTCOME MEASURES
Time to detection of visual field progression and optic disc progression.


RESULTS
Among study eyes with manifest glaucoma, progression was detected in the visual field first in 163 eyes (52%) and in the optic disc first in 39 eyes (12%); in 1 eye (0%), it was found simultaneously with both methods. Among fellow eyes with normal fields, progression was detected in the visual field first in 28 eyes (15%) and in the optic disc first in 34 eyes (18%); in 1 eye (1%), it occurred simultaneously.


CONCLUSIONS
In eyes with manifest glaucoma, progression in the visual field was detected first more than 4 times as often as progression in the optic disc. Among fellow eyes without visual field loss at baseline, progression was detected first as frequently in the optic disc as in the visual field.
Robust control of speed and temperature in a power plant gas turbine.

In this paper, an H(∞) robust controller has been designed for an identified model of MONTAZER GHAEM power plant gas turbine (GE9001E). In design phase, a linear model (ARX model) which is obtained using real data has been applied. Since the turbine has been used in a combined cycle power plant, its speed and also the exhaust gas temperature should be adjusted simultaneously by controlling fuel signals and compressor inlet guide vane (IGV) position. Considering the limitations on the system inputs, the aim of the control is to maintain the turbine speed and the exhaust gas temperature within desired interval under uncertainties and load demand disturbances. Simulation results of applying the proposed robust controller on the nonlinear model of the system (NARX model), fairly fulfilled the predefined aims. Simulations also show the improvement in the performance compared to MPC and PID controllers for the same conditions.
Ethnicity and neighbourhood deprivation determines the response rate in sexual dysfunction surveys

Self-administered questionnaires provide a better alternative to disclose sensitive information in sexual health research. We describe the factors that determine the positive response (initial recruitment) to an initial invitation and subsequent completion of study to a postal questionnaire on sexual dysfunction. South Asians (SA) and Europids with and without diabetes (DM) were recruited from GP clinics in UK. Men who returned the properly filled consent form (‘recruited-group’) were sent the questionnaire and those who returned it were considered as the ‘completed-group’. Index of Multiple Deprivation Scores (IMDs) were generated using UK postcodes. We calculated the recruitment rate and completion rate of the recruited and the study-completed groups respectively. Total approached sample was 9100 [DM: 2914 (32 %), SA: 4563 (50.1 %)]. Recruitment rate was 8.8 % and was higher in Europids and in patients with DM. Mean IMDs for the recruited group was 20.9 ± 11.9, and it was higher among recruited SA compared to Europids (p < 0.001). Mean IMDs was higher in the recruited group compared to non-recruited (p < 0.01). All four recruited groups (SA/Europid and DM/non-DM) had lower IMDs compared to non-recruited. Completion rate was 71.5 % (n 544) (SA: 62.3 %, Europids: 77.4 %; p < 0.05). Recruitment for postal sexual health surveys is positively influenced by presence of investigated disease, older age, being from lesser deprived areas and Europid ethnicity. Furthermore, Europids were more likely to complete survey than South Asians irrespective of disease status.
Control of 3D limb dynamics in unconstrained overarm throws of different speeds performed by skilled baseball players.

This study investigated how the human CNS organizes complex three-dimensional (3D) ball-throwing movements that require both speed and accuracy. Skilled baseball players threw a baseball to a target at three different speeds. Kinematic analysis revealed that the fingertip speed at ball release was mainly produced by trunk leftward rotation, shoulder internal rotation, elbow extension, and wrist flexion in all speed conditions. The study participants adjusted the angular velocities of these four motions to throw the balls at three different speeds. We also analyzed the dynamics of the 3D multijoint movements using a recently developed method called "nonorthogonal torque decomposition" that can clarify how angular acceleration about a joint coordinate axis (e.g., shoulder internal rotation) is generated by the muscle, gravity, and interaction torques. We found that the study participants utilized the interaction torque to generate larger angular velocities of the shoulder internal rotation, elbow extension, and wrist flexion. To increase the interaction torque acting at these joints, the ball throwers increased muscle torque at the shoulder and trunk but not at the elbow and wrist. These results indicates that skilled ball throwers adopted a hierarchical control in which the proximal muscle torques created a dynamic foundation for the entire limb motion and beneficial interaction torques for distal joint rotations.
The effect of tocilizumab on bone mineral density in patients with methotrexate-resistant active rheumatoid arthritis.

OBJECTIVE
The aim of this study was to analyse the effects of therapy with tocilizumab (TCZ), an anti-IL-6 receptor antibody, on BMD of the lumbar spine and femoral neck in patients with RA.


METHODS
Eighty-six patients with active RA (indicated by a 28-joint DAS ESR >3.2) despite treatment with MTX 12 mg/week were included in this open-label prospective study and started on TCZ (8 mg/kg every 4 weeks). All patients used a stable dosage of MTX and were not allowed to use steroids or bisphosphonates during the study period. BMD of the lumbar spine and femoral neck was measured by dual-energy X-ray absorptiometry at baseline and 52 weeks after initiating TCZ.


RESULTS
Seventy-eight patients completed this study. BMD of the lumbar spine and femoral neck remained stable after 1 year of TCZ treatment. In 33 patients who had osteopenia at baseline, there was a significant increase in BMD of the lumbar spine [mean 0.022 (s.d.) 0.042, P < 0.05] and femoral neck [0.024 (0.0245), P < 0.05].


CONCLUSION
TCZ affects BMD in patients who had active RA despite treatment with MTX. BMD of the lumbar spine and femoral neck in patients with normal BMD at baseline was stable. TCZ increased the BMD of patients who had osteopenia at baseline.
Atrial Fibrillation Complexity Parameters Derived From Surface ECGs Predict Procedural Outcome and Long-Term Follow-Up of Stepwise Catheter Ablation for Atrial Fibrillation.

BACKGROUND
The success rate of catheter ablation for persistent atrial fibrillation (AF) is still far from satisfactory. Identification of patients who will benefit from ablation is highly desirable. We investigated the predictive value of noninvasive AF complexity parameters derived from standard 12-lead ECGs for AF termination and long-term success of catheter ablation and compared them with clinical predictors.


METHODS AND RESULTS
The study included a training (93 patients) and a validation set (81 patients) of patients with persistent AF undergoing stepwise radiofrequency ablation. In the training set AF terminated in 81% during catheter ablation, 77% were in sinus rhythm after 6 years and multiple ablations. ECG-derived complexity parameters were determined from a baseline 10-s 12-lead ECG. Prediction of AF termination was similar using only ECG (cross-validated mean area under the curve [AUC], 0.76±0.15) or only clinical parameters (mean AUC, 0.75±0.16). The combination improved prediction to a mean AUC of 0.79±0.13. Using a combined model of ECG and clinical parameters, sinus rhythm at long-term follow-up could be predicted with a mean AUC of 0.71±0.12. In the validation set AF terminated in 57%, 61% were in sinus rhythm after 4.6 years. The combined models predicted termination with an AUC of 0.70 and sinus rhythm at long-term follow-up with an AUC of 0.61. Overall, fibrillation-wave amplitude provided the best rhythm prediction.


CONCLUSIONS
The predictive performance of ECG-derived AF complexity parameters for AF termination and long-term success of catheter ablation in patients with persistent AF is at least as good as known clinical predictive parameters, with fibrillation-wave amplitude as the best predictor.
Improving Entity Linking by Modeling Latent Relations between Mentions

• In-domain: 91% F1 on the dev set, 5 we reduced the learning rate from 10−4 to 10−5. We then stopped the training when F1 was not improved after 20 epochs. We did the same for ment-norm except that the learning rate was changed at 91.5% F1. Note that all the hyper-parameters except K and the turning point for early stopping were set to the values used by Ganea and Hofmann (2017). Systematic tuning is expensive though may have further ncreased the result of our models.
Asset Pricing with Liquidity Risk ∗ Viral

This paper studies equilibrium asset pricing with liquidity risk — the risk arising from unpredictable changes in liquidity over time. It is shown that a security’s required return depends on its expected illiquidity and on the covariances of its own return and illiquidity with market return and market illiquidity. This gives rise to a liquidityadjusted capital asset pricing model. Further, if a security’s liquidity is persistent, a shock to its illiquidity results in low contemporaneous returns and high predicted future returns. Empirical evidence based on cross-sectional tests is consistent with liquidity risk being priced. We are grateful for conversations with Andrew Ang, Joseph Chen, Sergei Davydenko, Francisco Gomes, Joel Hasbrouck, Andrew Jackson, Tim Johnson, Martin Lettau, Anthony Lynch, Stefan Nagel, Dimitri Vayanos, Luis Viceira, Jeff Wurgler, and seminar participants at London Business School, New York University, the National Bureau of Economic Research (NBER) Summer Institute 2002, and the Five Star Conference 2002. We are especially indebted to Yakov Amihud for being generous with his time in guiding us through the empirical tests. All errors remain our own. Acharya is at London Business School and is a Research Affiliate of the Centre for Economic Policy Research (CEPR). Address: London Business School, Regent’s Park, London NW1 4SA, UK. Phone: +44 (0)20 7262 5050 x 3535. Fax: +44 (0)20 7724 3317. Email: vacharya@london.edu. Web: http://www.london.edu/faculty/vacharya Pedersen is at the Stern School of Business, New York University, 44 West Fourth Street, Suite 9-190, New York, NY 10012-1126. Phone: (212) 998-0359. Fax: (212) 995-4233. Email: lpederse@stern.nyu.edu. Web: http://www.stern.nyu.edu/∼lpederse/
Suicide attempts and nonsuicidal self-injury in the treatment of resistant depression in adolescents: findings from the TORDIA study.

OBJECTIVE
To evaluate the clinical and prognostic significance of suicide attempts (SAs) and nonsuicidal self-injury (NSSI) in adolescents with treatment-resistant depression.


METHOD
Depressed adolescents who did not improve with an adequate SSRI trial (N = 334) were randomized to a medication switch (SSRI or venlafaxine), with or without cognitive-behavioral therapy. NSSI and SAs were assessed at baseline and throughout the 24-week treatment period.


RESULTS
Of the youths, 47.4% reported a history of self-injurious behavior at baseline: 23.9% NSSI alone, 14% NSSI+SAs, and 9.5% SAs alone. The 24-week incidence rates of SAs and NSSI were 7% and 11%, respectively; these rates were highest among youths with NSSI+SAs at baseline. NSSI history predicted both incident SAs (hazard ratio [HR]= 5.28, 95% confidence interval [CI] = 1.80-15.47, z = 3.04, p = .002) and incident NSSI (HR = 7.31, z = 4.19, 95% CI = 2.88-18.54, p < .001) through week 24, and was a stronger predictor of future attempts than a history of SAs (HR = 1.92, 95% CI = 0.81-4.52, z = 2.29, p = .13). In the most parsimonious model predicting time to incident SAs, baseline NSSI history and hopelessness were significant predictors, adjusting for treatment effects. Parallel analyses predicting time to incident NSSI through week 24 identified baseline NSSI history and physical and/or sexual abuse history as significant predictors.


CONCLUSIONS
NSSI is a common problem among youths with treatment-resistant depression and is a significant predictor of future SAs and NSSI, underscoring the critical need for strategies that target the prevention of both NSSI and suicidal behavior.


CLINICAL TRIAL REGISTRATION INFORMATION
Treatment of SSRI-Resistant Depression in Adolescents (TORDIA). URL: http://www.clinicaltrials.gov. Unique Identifier: NCT00018902.
From kids and horses: equine facilitated psychotherapy for children

Equine facilitated psychotherapy is a developing form of animal assisted therapy, which primarily incorporates human interaction with horses as guides. The behavior of a sensitive horse, provides a vehicle by which the therapist can use to teach the patient coping skills. This theoretical study is present to reader our opinion, about the main considerations of equine facilitated psychotherapy for children. In this scenario, the horse could be included as a cotherapist in a team composed of psychologist, occupational therapists, veterinary doctors and horsemen. Horses, by their large, gentle presence, put children therapeutically in touch with their own vitality. Children who ordinarily shun physical and emotional closeness often can accept from a horse. Beneficial results of a child-horse relationship include care translation, socialization and conversation, self-esteem promotion, companionship and affection stimulation. We conclude that equine facilitated psychotherapy provides well being and improvement in quality of children with mental health problems.