LLukas22/scidocs huggingface dataset:
The emergence and development of the professional consciousness of the future teacher

In the psychology of professional education there has been a noticeable shift of research interest away from the formulation of descriptive-normative models of the personality and activity of the specialist on the basis of which the requirements on the content of his professional training used to be formulated (the professiographic approach) and toward the study of the professional consciousness and self-awareness of the agent of the activity, his values, semantic formations, and reflection. It is becoming necessary to go beyond the limits of the narrowly technological interpretation of professional activity into the sphere of the psychology of consciousness [4], the development of which is viewed as the basic content of the process of professionalization [17]. A number of studies have pointed to the necessity of carrying out the kind of research on professional consciousness that will discover and substantiate ways by which it can be shaped in a goal-directed manner, because "professional consciousness n...
Triple-class virologic failure in HIV-infected patients undergoing antiretroviral therapy for up to 10 years.

BACKGROUND
Life expectancy of people with human immunodeficiency virus (HIV) is now estimated to approach that of the general population in some successfully treated subgroups. However, to attain these life expectancies, viral suppression must be maintained for decades.


METHODS
We studied the rate of triple-class virologic failure (TCVF) in patients within the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) who started antiretroviral therapy (ART) that included a nonnucleoside reverse-transcriptase inhibitor (NNRTI) or a ritonavir-boosted protease inhibitor (PI/r) from 1998 onwards. We also focused on TCVF in patients who started a PI/r-containing regimen after a first-line NNRTI-containing regimen failed.


RESULTS
Of 45 937 patients followed up for a median (interquartile range) of 3.0 (1.5-5.0) years, 980 developed TCVF (2.1%). By 5 and 9 years after starting ART, an estimated 3.4% (95% confidence interval [CI], 3.1%-3.6%) and 8.6% (95% CI, 7.5%-9.8%) of patients, respectively, had developed TCVF. The incidence of TCVF rose during the first 3 to 4 years on ART but plateaued thereafter. There was no significant difference in the risk of TCVF according to whether the initial regimen was NNRTI or PI/r based (P = .11). By 5 years after starting a PI/r regimen as second-line therapy, 46% of patients had developed TCVF.


CONCLUSIONS
The rate of virologic failure of the 3 original drug classes is low, but not negligible, and does not appear to diminish over time from starting ART. If this trend continues, many patients are likely to need newer drugs to maintain viral suppression. The rate of TCVF from the start of a PI/r regimen after NNRTI failure provides a comparator for studies of response to second-line regimens in resource-limited settings.
Two Distinct Pathways to Development of Squamous Cell Carcinoma of the Vulva

Squamous cell carcinoma (SCC) accounts for approximately 95% of the malignant tumors of the vaginal vulva and is mostly found in elderly women. The future numbers of patients with vulvar SCC is expected to rise, mainly because of the proportional increase in the average age of the general population. Two different pathways for vulvar SCC have been put forth. The first pathway is triggered by infection with a high-risk-type Human Papillomavirus (HPV). Integration of the HPV DNA into the host genome leads to the development of a typical vulvar intraepithelial neoplasia (VIN), accompanied with overexpression of p14(ARF) and p16(INK4A). This lesion subsequently forms a warty- or basaloid-type SCC. The HPV vaccine is a promising new tool for prevention of this HPV related SCC of the vulva. The second pathway is HPV-independent. Keratinizing SCC develops within a background of lichen sclerosus (LS) through a differentiated VIN. It has a different set of genetic alterations than those in the first pathway, including p53 mutations, allelic imbalances (AI), and microsatellite instability (MSI). Further clinical and basic research is still required to understand and prevent vulvar SCC. Capsule. Two pathway for pathogenesis of squamous cell carcinoma of the value are reviewed.
and later intelligence quotient Randomised trial of early diet in preterm babies

Objectives To determine whether perinatal nutrition influences cognitive function at 71⁄2-8 years in children born preterm. Design Randomised, blinded nutritional intervention trial. Blinded follow up at 71⁄2-8 years. Setting Intervention phase in two neonatal units; follow up in a clinic or school setting. Subjects 424 preterm infants who weighed under 1850 g at birth; 360 of those who survived were tested at 71⁄2-8 years. Interventions Standard infant formula versus nutrient enriched preterm formula randomly assigned as sole diet (trial A) or supplements to maternal milk (trial B) fed for a mean of 1 month. Main outcome measures Intelligence quotient (IQ) at 71⁄2-8 years with abbreviated Weschler intelligence scale for children (revised). Results There was a major sex difference in the impact of diet. At 71⁄2-8 years boys previously fed standard versus preterm formula as sole diet had a 12.2 point disadvantage (95% confidence interval 3.7 to 20.6; P < 0.01) in verbal IQ. In those with highest intakes of trial diets corresponding figures were 9.5 point disadvantage and 14.4 point disadvantage in overall IQ (1.2 to 17.7; P < 0.05) and verbal IQ (5.7 to 23.2; P < 0.01). Consequently, more infants fed term formula had low verbal IQ ( < 85): 31% versus 14% for both sexes (P = 0.02) and 47% versus 13% in boys P = 0.009). There was a higher incidence of cerebral palsy in those fed term formula; exclusion of such children did not alter the findings. Conclusions Preterm infants are vulnerable to suboptimal early nutrition in terms of their cognitive performance—notably, language based skills—at 71⁄2-8 years, when cognitive scores are highly predictive of adult ones. Our data on cerebral palsy generate a new hypothesis that suboptimal nutritional management during a critical or plastic early period of rapid brain growth could impair functional compensation in those sustaining an earlier brain insult. Cognitive function, notably in males, may be permanently impaired by suboptimal neonatal nutrition.
Organic Chemistry: Techniques and Transformations

This part should be filled in after the completion of the experiment and analysis of all data. When submitting the report, the abstract should appear at the beginning of the report.
The optimal dose of 5-aminosalicylic acid in active ulcerative colitis: a dose-finding study with newly developed mesalamine.

BACKGROUND AND AIMS
5-Aminosalicylate is the gold standard for inducing remission in patients with mildly to moderately active ulcerative colitis. The optimal dose is as yet not defined. Despite some recent developments, the ideal formulation for 5-aminosalicylic acid is still awaited. A new pellet preparation was designed combining slow and delayed release properties. Aims of the study were to find the optimal dose and to test efficacy and safety of a new 5-aminosalicylic acid formulation.


METHODS
Three hundred twenty-one patients were included in a double-blind multicenter trial. Inclusion criteria were active ulcerative colitis (Clinical Activity Index [CAI] and Endoscopic Index [EI] according to Rachmilewitz, CAI 6-12; EI >/=4). Three different doses of 5-aminosalicylic acid (0.5 g 3 times a day, 1.0 g 3 times a day, and 1.5 g 3 times a day) were studied for 8 weeks.


RESULTS
Clinical remission rate (CAI </=4) was highest in the 1.0 g 3 times a day group (66 %), 50% in the 0.5 g 3 times a day group, and 55% in the 1.5 g 3 times a day group. Hierarchical testing showed no significance, indicating a lack of dose response across the 3 mesalamine doses. In addition, times to first clinical response were similar: 26.5 days (1.0 g 3 times a day), 27.5 days (0.5 g 3 times a day), and 21.5 days (1.5 g 3 times a day). Endoscopic improvement was better with 1.0 g mesalamine 3 times a day than with 0.5 g 3 times a day, but overall endoscopic and histologic improvement was not different between treatment groups. Baseline activity, duration, and localization of ulcerative colitis did have some influence on the therapeutic activity, but there was no significant interaction with the dose of the study drug. Safety, with special focus on kidney function, was excellent in all 3 groups.


CONCLUSIONS
There is no significant dose response between mesalamine 1.5 g/day, 3.0 g/day, and 4.5 g/day. The optimal dose to induce remission of ulcerative colitis is 0.5 g 5-aminosalicylic acid 3 times a day. Patients failing with this dose may benefit from an increase of the dose up to 1.0 g 3 times a day, but should also be considered for alternative treatment. A newly developed pellet formulation of 5-aminosalicylic acid has promising efficacy and excellent safety.
Data Curation with Deep Learning [Vision]: Towards Self Driving Data Curation

Past. Data curation – the process of discovering, integrating, and cleaning data – is one of the oldest data management problems. Unfortunately, it is still the most time consuming and least enjoyable work of data scientists. So far, successful data curation stories are mainly ad-hoc solutions that are either domain-specific (for example, ETL rules) or task-specific (for example, entity resolution). Present. In the era of big data, data curation plays the critical role of taking the value of big data to a new level. However, the power of current data curation solutions are not keeping up with the ever changing data ecosystem in terms of volume, velocity, variety and veracity, mainly due to the high human cost, instead of machine cost, needed for providing the ad-hoc solutions mentioned above. Meanwhile, deep learning is making strides in achieving remarkable successes in areas such as image recognition, natural language processing, and speech recognition. This is largely due to its ability of (automatically) understanding data (features) that are neither domain-specific nor task-specific. Future. Data curation solutions need to keep the pace with the fast-changing data ecosystem, where the main hope is to devise domain-agnostic and task-agnostic solutions. To this end, we start a new, five-year research project, called AutoDC, to unleash the potential of deep learning towards self-driving data curation. We will discuss how different deep learning concepts (for example, distributed representations, model pre-training, transfer learning, and neural program synthesis) can be adapted and extended to solve various data curation problems. We will also showcase some low-hanging fruits about the early encounters between deep learning and data curation happening in AutoDC. We believe that the directions pointed out by this work will not only drive AutoDC towards democratizing data curation, but also serve as a cornerstone for researchers and practitioners to move to a new realm of data curation solutions. PVLDB Reference Format: Saravanan Thirumuruganathan, Nan Tang & Mourad Ouzzani. Data Curation with Deep Learning. PVLDB, 11 (5): xxxx-yyyy, 2018. DOI: https://doi.org/TBD
Explaining the variability improvements in gait quality as a result of single event multi-level surgery in cerebral palsy.

PURPOSE
This is a study of all children with spastic diplegic cerebral palsy (Gross Motor Classification System levels II and III) who had single event multi-level surgery (SEMLS) at a single tertiary referral hospital between 1995 and 2008 to identify factors predicting improvement in gait quality as quantified by the gait profile score (GPS). 9 factors (5 dichotomous and 4 continuous, including preoperative GPS) that might be expected to predict outcomes were identified and univariate and multivariable analysis used to explore how these affected outcomes.


SCOPE
Data from 121 children were included. The mean improvement in GPS of 4.3° was 2.7 times the minimal clinically important difference. Univariate analysis suggested that preoperative GPS is a very strong predictor of improvement in GPS (p<10(-5)) and when this is considered as a covariate only GMFCS level (p=10(-5)) and having had previous surgery (p=0.026) were found to be statistically significant predictors of GPS improvement (p<0.05). Children of GMFCS level II improved on average by 2° more than those of level III once differences in preoperative GPS had been accounted for.


CONCLUSION
Children with the most abnormal gait patterns preoperatively, and hence those with the most potential to improve are those that improve the most and surgery has clearly been beneficial. Over a quarter of children show changes in GPS which were less than the MCID. The majority of these were those with the least abnormal gait patterns preoperatively and further research is required to establish whether and how such children benefit from SEMLS.
Evidence for the protracted construction of slow-spread oceanic crust by small magmatic injections

Abstract Gabbroic cumulates drilled south of the Kane Transform Fault on the slow-spread Mid-Atlantic Ridge preserve up to three discrete magnetization components. Here we use absolute age constraints derived from the paleomagnetic data to develop a model for the magmatic construction of this section of the lower oceanic crust. By comparing the paleomagnetic data with mineral compositions, and based on thermal models of local reheating, we infer that magmas that began crystallizing in the upper mantle intruded into the lower oceanic crust and formed meter-scale sills. Some of these magmas were crystal-laden and the subsequent expulsion of interstitial liquid from them produced ‘cumulus’ sills. These small-scale magmatic injections took place over at least 210 000 years and at distances of ∼3 km from the ridge axis and may have formed much of the lower crust. This model explains many of the complexities described in this area and can be used to help understand the general formation of oceanic crust at slow-spread ridges.
Effect of percutaneous thrombectomy on echocardiographic measures of myocardial microcirculation in elderly patients with acute myocardial infarction.

OBJECTIVES
To study the efficacy of percutaneous thrombectomy (PT) in improving myocardial microcirculation in elderly acute myocardial infarction (AMI) patients.


METHODS
A total of 104 patients (> or = 65 years) with AMI and coronary thrombus shown by angiography were randomly divided into a group of percutaneous coronary intervention (PCI) (n=52) and a group of PCI plus PT (n=52). At 24 h and 1 week after PCI, real-time myocardial contrast echocardiography was performed by contrast pulse sequencing technology. Contrast score index, contrast defect length/left ventricle length [CDL/LVL (%)], wall motion score index and wall motion abnormal length/LVL (%) were calculated.


RESULTS
At each time point, in patients treated with PCI plus PT, contrast score index, CDL/LVL (%), wall motion score index and wall motion abnormal length/LVL (%) were significantly lower than that in the PCI group.


CONCLUSION
Thrombectomy reduces the noreflow and the extent of microvascular obstruction, thus it was a feasible therapy in elderly patients with AMI.
Association of subclinical hypercortisolism with type 2 diabetes mellitus: a case-control study in hospitalized patients.

OBJECTIVE
Subclinical hypercortisolism (SH) may play a role in several metabolic disorders, including diabetes. No data are available on the relative prevalence of SH in type 2 diabetes (T2D). In order to compare the prevalence of SH in T2D and matched non-diabetic control individuals, we performed a case-controlled, multicenter, 12-month study, enrolling 294 consecutive T2D inpatients (1.7% dropped out the study) with no evidence of clinical hypercortisolism and 189 consecutive age- and body mass index-matched non-diabetic inpatients (none of whom dropped out).


DESIGN AND METHODS
Ascertained SH (ASH) was diagnosed in individuals (i) with plasma cortisol after 1 mg overnight dexamethasone suppression >1.8 microg/dl (50 nmol/l), (ii) with more than one of the following: (a) urinary free cortisol >60.0 microg/24 h (165.6 nmol/24 h), (b) plasma ACTH <10.0 pg/ml (2.2 pmol/l) or (c) plasma cortisol >7.5 microg/dl (207 nmol/l) at 24:00 h or >1.4 microg/dl (38.6 nmol/l) after dexamethasone-CRH (serum cortisol after corticotrophin-releasing hormone stimulus during dexamethasone administration) test, and (iii) in whom the source of glucocorticoid excess was suggested by imaging and by additional biochemical tests (for ACTH-dependent ASH).


RESULTS
Prevalence of ASH was higher in diabetic individuals than in controls (9.4 versus 2.1%; adjusted odds ratio, 4.8; 95% confidence interval, 1.6-14.1; P = 0.004). In our population the proportion of T2D which is statistically attributable to ASH was approx. 7%. Among diabetic patients, the presence of severe diabetes (as defined by the coexistence of hypertension, dyslipidaemia and insulin treatment) was significantly associated with SH (adjusted odds ratio, 3.8; 95% confidence interval, 1.4-10.2; P = 0.017).


CONCLUSIONS
In hospitalized patients, SH is associated with T2D.
Management of an academic HPC cluster: The UL experience

The intensive growth of processing power, data storage and transmission capabilities has revolutionized many aspects of science. These resources are essential to achieve high-quality results in many application areas. In this context, the University of Luxembourg (UL) operates since 2007 an High Performance Computing (HPC) facility and the related storage by a very small team. The aspect of bridging computing and storage is a requirement of UL service - the reasons are both legal (certain data may not move) and performance related. Nowadays, people from the three faculties and/or the two Interdisciplinary centers within the UL, are users of this facility. More specifically, key research priorities such as Systems Bio-medicine (by LCSB) and Security, Reliability & Trust (by SnT) require access to such HPC facilities in order to function in an adequate environment. The management of HPC solutions is a complex enterprise and a constant area for discussion and improvement. The UL HPC facility and the derived deployed services is a complex computing system to manage by its scale: at the moment of writing, it consists of 150 servers, 368 nodes (3880 computing cores) and 1996 TB of shared storage which are all configured, monitored and operated by only three persons using advanced IT automation solutions based on Puppet [1], FAI [2] and Capistrano [3]. This paper covers all the aspects in relation to the management of such a complex infrastructure, whether technical or administrative. Most design choices or implemented approaches have been motivated by several years of experience in addressing research needs, mainly in the HPC area but also in complementary services (typically Web-based). In this context, we tried to answer in a flexible and convenient way many technological issues. This experience report may be of interest for other research centers and universities belonging either to the public or the private sector looking for good if not best practices in cluster architecture and management.
A controlled crossover study of the selective serotonin reuptake inhibitor citalopram in irritable bowel syndrome.

INTRODUCTION
Selective serotonin reuptake inhibitors (SSRIs) are frequently used in the treatment of irritable bowel syndrome (IBS) although evidence of their efficacy is scarce.


AIM
Twenty three non-depressed IBS patients were recruited from a tertiary care centre and included in a crossover trial comparing six weeks of treatment with the SSRI citalopram (20 mg for three weeks, 40 mg for three weeks) with placebo. IBS symptom severity was the primary outcome measure, and depression and anxiety scores were also measured. The effect of acute administration of citalopram on colonic sensitivity and on colonic response to feeding was investigated as a putative predictor of symptomatic response to the drug.


RESULTS
After three and six weeks of treatment, citalopram significantly improved abdominal pain, bloating, impact of symptoms on daily life, and overall well being compared with placebo. There was only a modest effect on stool pattern. Changes in depression or anxiety scores were not related to symptom improvement. The effect of acute administration of citalopram during a colonic barostat study did not predict clinical outcome. Analysis of the first treatment period as a double blind parallel arm study confirmed the benefit of citalopram over placebo.


CONCLUSIONS
The SSRI citalopram significantly improves IBS symptoms, including abdominal pain, compared with placebo. The therapeutic effect is independent of effects on anxiety, depression, and colonic sensorimotor function.
ESTIMATION OF INBUILT AGE IN RADIOCARBON AGES OF SOIL CHARCOAL FOR FIRE HISTORY STUDIES

Radiocarbon age determinations of wood charcoal are commonly used to date past forest fire events, even though such ages should be greater than the fire event due to the age of the wood at the time of burning. The difference in the 14C-derived age of charcoal and the time-since-fire (the “inbuilt age”) may be considerable in some vegetation types and thus must be estimated before interpreting fire dates. Two methods were used to estimate the potential range of inbuilt age of soil charcoal dated to determine ages of forest fires on the west coast of Vancouver Island (Canada). First, 26 14C ages on charcoal in surficial soil were compared directly with ages of forest fire determined by tree-ring counts, suggesting inbuilt ages of 0– 670 years. Second, a simulation model that uses estimated fuel loads, fuel consumption, charcoal production, and the ages of charred wood (time since wood formation), suggests that the combination of slow growth rates and slow decay rates of certain species can account for inbuilt ages of more than 400 years in this forest type. This level of inbuilt age is large enough such that the actual age of a fire may not occur within the 2σ confidence interval of a calibrated charcoal 14C age determination, and thus significantly affect the interpretation of fire dates. A method is presented to combine the error of a calibrated 14C age determination with the error due to inbuilt age such that the larger adjusted error encompasses the actual age of the fire.