LLukas22/scidocs huggingface dataset:
A Mobile GPRS-Sensors Array for Air Pollution Monitoring

An online GPRS-Sensors Array for air pollution monitoring has been designed, implemented, and tested. The proposed system consists of a Mobile Data-Acquisition Unit (Mobile-DAQ) and a fixed Internet-Enabled Pollution Monitoring Server (Pollution-Server). The Mobile-DAQ unit integrates a single-chip microcontroller, air pollution sensors array, a General Packet Radio Service Modem (GPRS-Modem), and a Global Positioning System Module (GPS-Module). The Pollution-Server is a high-end personal computer application server with Internet connectivity. The Mobile-DAQ unit gathers air pollutants levels (CO, NO2, and SO2), and packs them in a frame with the GPS physical location, time, and date. The frame is subsequently uploaded to the GPRS-Modem and transmitted to the Pollution-Server via the public mobile network. A database server is attached to the Pollution-Server for storing the pollutants level for further usage by various clients such as environment protection agencies, vehicles registration authorities, and tourist and insurance companies. The Pollution-Server is interfaced to Google Maps to display real-time pollutants levels and locations in large metropolitan areas. The system was successfully tested in the city of Sharjah, UAE. The system reports real-time pollutants level and their location on a 24-h/7-day basis.
Diagnostic accuracy of neurological problems in the emergency department.

BACKGROUND
Previous studies describe significant rates of misdiagnosis of stroke, seizure and other neurological problems, but there are few studies examining diagnostic accuracy of all emergency referrals to a neurology service. This information could be useful in focusing the neurological education of physicians who assess and refer patients with neurological complaints in emergency departments.


METHODS
All neurological consultations in the emergency department at a tertiary-care teaching hospital were recorded for six months. The initial diagnosis of the requesting physician was recorded for each patient. This was compared to the initial diagnosis of the consulting neurologist and to the final diagnosis, as determined by retrospective chart review.


RESULTS
Over a six-month period, 493 neurological consultations were requested. The initial diagnosis of the requesting physician agreed with the final diagnosis in 60.4% (298/493) of cases, and disagreed or was uncertain in 35.7% of cases (19.1% and 16.6% respectively). In 3.9% of cases, the initial diagnosis of both the referring physician and the neurologist disagreed with the final diagnosis. Common misdiagnoses included neurocardiogenic syncope, peripheral vertigo, primary headache and psychogenic syndromes. Often, these were initially diagnosed as stroke or seizure.


CONCLUSIONS
Our data indicate that misdiagnosis or diagnostic uncertainty occurred in over one-third of all neurological consultations in the emergency department setting. Benign neurological conditions, such as migraine, syncope and peripheral vertigo are frequently mislabeled as seizure or stroke. Educational strategies that emphasize emergent evaluation of these common conditions could improve diagnostic accuracy, and may result in better patient care.
Political Ideologies and Political Parties in America

1. Introduction: distilling their frenzy from some academic scribbler 2. The coalition merchants: ideologies, parties, and their interaction 3. Creative synthesis: why ideology? 4. The independent development of ideology 5. Ideology remakes the parties 6. Issue politics in ideological context 7. Polarized parties 8. Conclusion: toward the study of creative synthesis.
Understanding the differences between contrasting HIV epidemics in east and west Africa: results from a simulation model of the Four Cities Study.

OBJECTIVE
To determine if the differences in risk behaviours, the proportions of males circumcised and prevalences of sexually transmitted infections (STIs) observed in two African cities with low prevalence of HIV (Cotonou, Benin, and Yaoundé, Cameroon) and two cities with high prevalence (Kisumu, Kenya, and Ndola, Zambia) could explain the contrasting HIV epidemics in the four cities.


METHODS
An individual-based stochastic model, STDSIM, was fitted to the demographic, behavioural and epidemiological characteristics of the four urban study populations based on data from the Four Cities Study and other relevant sources. Model parameters pertaining to STI and HIV natural history and transmission were held constant across the four populations. The probabilities of HIV, syphilis and chancroid acquisition were assumed to be doubled among uncircumcised males. A priori plausible ranges for model inputs and outputs were defined and sexual behaviour characteristics, including those pertaining to commercial sex workers (CSWs) and their clients, which were allowed to vary across the sites, were identified based on comparisons of the empirical data from the four sites. The proportions of males circumcised in the model, 100% in Cotonou and Yaoundé, 25% in Kisumu and 10% in Ndola, were similar to those observed. A sensitivity analysis was conducted to assess how changes in critical parameters may affect the model fit.


RESULTS
Population characteristics observed from the study that were replicated in the model included younger ages at sexual debut and marriage in east Africa compared with west Africa and higher numbers of casual partners in the past 12 months in Yaoundé than in the other three sites. The patterns in prevalence of STIs in females in the general population and CSWs were well fitted. HIV prevalence by age and sex and time trends in prevalence in the model were consistent with study data with the highest simulated prevalences in Kisumu and Ndola, intermediate in Yaoundé and lowest in Cotonou. The sensitivity analysis suggested that the effect of circumcision on the development of the HIV epidemics may have been mediated indirectly by its effect on ulcerative STI.


CONCLUSIONS
The contrasting HIV epidemics in east and west Africa could be replicated in our model by assuming that male circumcision reduced susceptibility to HIV, syphilis and chancroid. Varying rates of male circumcision may have played an important role in explaining the strikingly different HIV epidemics observed in different parts of sub-Saharan Africa.
Effect of atazanavir versus other protease inhibitor-containing antiretroviral therapy on endothelial function in HIV-infected persons: randomised controlled trial.

OBJECTIVE
Impaired endothelial function was demonstrated in HIV-infected persons on protease inhibitor (PI)-containing antiretroviral therapy, probably due to altered lipid metabolism. Atazanavir is a PI causing less atherogenic lipoprotein changes. This study determined whether endothelial function improves after switching from other PI to atazanavir.


DESIGN
Randomised, observer-blind, treatment-controlled trial.


SETTING
Three university-based outpatient clinics.


PATIENTS
39 HIV-infected persons with suppressed viral replication on PI-containing regimens and fasting low-density lipoprotein (LDL)-cholesterol greater than 3 mmol/l.


INTERVENTION
Patients were randomly assigned to continue the current PI or change to unboosted atazanavir.


MAIN OUTCOME MEASURES
Endpoints at week 24 were endothelial function assessed by flow-mediated dilation (FMD) of the brachial artery, lipid profiles and serum inflammation and oxidative stress parameters.


RESULTS
Baseline characteristics and mean FMD values of the two treatment groups were comparable (3.9% (SD 1.8) on atazanavir versus 4.0% (SD 1.5) in controls). After 24 weeks' treatment, FMD decreased to 3.3% (SD 1.4) and 3.4% (SD 1.7), respectively (all p = ns). Total cholesterol improved in both groups (p<0.0001 and p = 0.01, respectively) but changes were more pronounced on atazanavir (p = 0.05, changes between groups). High-density lipoprotein and triglyceride levels improved on atazanavir (p = 0.03 and p = 0.003, respectively) but not in controls. Serum inflammatory and oxidative stress parameters did not change; oxidised LDL improved significantly in the atazanavir group.


CONCLUSIONS
The switch from another PI to atazanavir in treatment-experienced patients did not result in improvement of endothelial function despite significantly improved serum lipids. Atherogenic lipid profiles and direct effects of antiretroviral drugs on the endothelium may affect vascular function.


TRIAL REGISTRATION NUMBER
NCT00447070.
Continuous speech recognition by statistical methods

Statistical methods useful in automatic recognition of continuous speech are described. They concern modeling of a speaker and of an acoustic processor, extraction of the models' statistical parameters and hypothesis search procedures and likelihood computations of linguistic decoding. Experimental results are presented that indicate the power of the methods.
Crustal melting in the Himalayan orogen : field, geochemical and geochronological studies in the Everest region, Nepal

A combination of field studies and geochemical techniques were used to investigate the timing and processes involved in leucogranite generation in the Everest region of the Himalayan orogen. Geochemical investigations focused on samples from three outcrops at different structural levels in the Himalayan metamorphic core where in situ crustal melting and multiple generations of leucogranite intrusions were observed. Accessory phase thermochronological and U-Pb geochronological studies were combined to determine the timing of anatexis in a migmatite at the structurally lowest outcrop. Quantitative measurement of REE and Y in monazites and xenotimes, that were later dissolved and dated by U-Pb IDTIMS, revealed monazite growth at temperatures appropriate for crustal melting (>650*C) between 25.4 and 24.8 Ma, suggesting that anatexis was ongoing at that time. Further constraints were placed on the timing of crustal melting, granite crystallization and cooling with a detailed U-Pb IDTIMS and 40Ar/39Ar study of leucogranite dikes, sills, and the metamorphic rocks they intrude. Backscattered electron imaging of accessory minerals provided important insights into the petrogenesis of monazite, xenotime and zircon, and guided efforts to isolate accessory phase growth domains. In two granitic sills, extensive accessory phase crystallization between ca. 26 and ca. 23 Ma was interpreted to be the result of episodic to semi-continuous melt generation and crystallization at least between those times. These melt products were later entrained in melts that crystallized as syntectonic sills at 21-22 Ma. Younger crosscutting dikes crystallized between 17.5 and 18.3 Ma. The range in accessory phase dates from these dikes and sills that represent magmatic crystallization ages spans from 26.2 to 17.5 Ma, providing evidence for melt generation in one region over roughly 9 million years. Neodymium isotopic signatures of the same monazite and xenotime grains dated by U-Pb IDTIMS were used to investigate melting processes and granite source-rock characteristics. The dominant control of monazite on the Nd isotopic composition of its host rock was clearly demonstrated. Some Nd isotopic heterogeneities recorded in monazite and in xenotime support a model for melt generation where accessory phases grow from locally derived sources in an isotopically heterogeneous melt. Thesis Supervisor: Kip V. Hodges Title: Professor of Geology
Probiotic treatment of vancomycin-resistant enterococci: a randomised controlled trial. Comment.

OBJECTIVE: To determine whether eating Lactobacillus rhamnosus GG (LGG) in the form of commercially available yoghurt improves clearance of vancomycin-resistant enterococci (VRE). DESIGN: Double-blind, randomised, placebo-controlled trial. SETTING: Renal ward of Austin Health, a tertiary hospital, Feb-Oct 2005. PARTICIPANTS: 27 VRE-positive patients, 14 receiving active treatment and 13 controls. INTERVENTIONS: Subjects were randomly assigned to either a treatment group (receiving 100 g daily of yoghurt containing LGG for 4 weeks) or a control group (receiving standard pasteurised yoghurt). Faecal samples were obtained three times at about weekly intervals. Treated patients were tested for VRE again at 8 weeks. Patients in the control group who had failed to clear VRE after 4 weeks were then given LGG-containing yoghurt for 4 weeks, as an open continuation. MAIN OUTCOME MEASURE: Number of faecal specimens clear of VRE. RESULTS: Of the 27 patients enrolled, 23 completed the study. Two patients were lost to follow-up, one died and one withdrew. All 11 patients in the treatment group who completed the study cleared VRE. Three subjects reverted to VRE positivity after using antibiotics to which LGG is sensitive, while all others remained negative for at least 4 weeks after trial completion. Twelve control subjects completed the study, of whom one cleared VRE and 11 remained VREpositive. Eight of these 11 patients were subsequently crossed over to receive LGG yoghurt, and all cleared VRE within 4 weeks. CONCLUSION: To our knowledge, this is the first description of a probiotic therapy to successfully treat gastrointestinal carriage of VRE in renal patients. Further investigation of the use of LGG in VRE-positive patients is warranted.
Biosimilars: controversies as illustrated by rhGH.

UNLABELLED
Abstract Background and scope: Similar biological medicinal products, also called 'biosimilars', are copies of biopharmaceutical products whose patent has expired. Whether biosimilars are truly comparable and interchangeable with their reference biopharmaceutical products in terms of quality, efficacy and tolerability, is still a matter of debate. This review discusses the controversies related to the criteria for regulatory approval of biosimilars. These concerns are illustrated using recombinant human growth hormone (rhGH) biosimilars as an example.


METHODS
Publications on the regulatory approval of biosimilars in general and rhGH biosimilars in particular were searched in MEDLINE by exploding and combining the medical subject heading terms 'human growth hormone', 'efficacy' or 'safety' and the free-text words 'biosimilar', 'biopharmaceutical', 'similar biological medicinal product', 'follow-up biologic' or 'biogeneric'. Searches were limited to full-text English-language articles. The websites from the European Medicines Agency (EMA) and from the American Food and Drug Administration were also consulted. Regulatory status: To obtain regulatory approval of a biosimilar product by EMA, demonstration of comparability with an approved reference biopharmaceutical product in terms of quality, efficacy and tolerability is needed. Thus, comparative quality studies, non-clinical and clinical efficacy and tolerability studies are required. However, in contrast to the reference product, comparative non-clinical pharmacokinetics, safety pharmacology, reproduction toxicology, mutagenicity and carcinogenicity studies are not mandatory to obtain approval of a biosimilar. In addition, comparable efficacy and tolerability only needs to be established by one study in a single population during a limited time interval (12 months) and often allows extrapolation to all other approved indications of the reference product. Consequently, for the currently approved rhGH biosimilars, long-term efficacy and tolerability in all indications has not been proven to the same degree as for the reference products.


CONCLUSIONS
The validity of the current criteria for comparability and interchangeability of biosimilars and their reference products remains controversial. The authors conclude that long-term clinical investigations and systematic monitoring of the efficacy and tolerability of rhGH biosimilars in all indications are needed. In addition, the medico-economical environment should allow physicians to take a free and informed decision about the type of rhGH to be prescribed.
A Focused Backpropagation Algorithm for Temporal Pattern Recognition

Time is at th e heart of many pat tern recognition t asks, e.g., speech recognit ion . However, connectionis t learning algorithms to date are not well suited for dealing with tim e-varying input patterns. This paper introduces a specialized connectionist architecture and corre sponding specialization of the backpropagation learnin g algori thm th at opera tes efficiently on temporal sequences . The key feature of t he archit ecture is a layer of self-connecte d hidden units that integrate their curre nt value with th e new input at each time ste p to construct a static represent ation of the temporal input sequence . Thi s architecture avoids two deficiencies found in other models of sequence recognition: first , i t reduces the difficulty of temporal credit assignm ent by focusing th e backpropagated err or signal; second, it eliminates the need for a buffer to hold th e input sequence and/or intermediat e activity levels. The lat ter prop erty is due to the fact th at during th e forward (activation) phase, incremental activity tra ces can be locally compute d that hold all information necessar y for backpropagation in time . It is argued tha t thi s architecture should scale better t han conventional recurrent architectures wit h respect to sequenc e length . The architecture has been used to implement a temporal version of Rumelhart and McClelland's verb past-tense model [1]. The hidden units learn to beh ave something like Rumelhart and McClelland 's "Wickelphones," a rich and flexibl e representation of temporal information.
Hepatic Fibrosis Progression in HIV-Hepatitis C Virus Co-Infection – The Effect of Sex on Risk of Significant Fibrosis Measured by Aspartate-to-Platelet Ratio Index

BACKGROUND
In Hepatitis C virus (HCV) mono-infection, male sex is associated with faster liver fibrosis progression but the effects of sex have not been well studied in HIV-HCV co-infected patients. We examined the influence of sex on progression to significant liver fibrosis in HIV-HCV co-infected adults receiving antiretroviral therapy (ART) using the aspartate aminotransferase-to-platelet ratio index (APRI) as a surrogate biomarker of liver fibrosis.


METHODS
We evaluated 308 HIV infected, HCV RNA positive participants of a Canadian multicentre prospective cohort receiving antiretrovirals and without significant liver fibrosis or end-stage liver disease at baseline. We used multivariate discrete-time proportional hazards models to assess the effect of sex on time to significant fibrosis (APRI≥1.5) adjusting for baseline age, alcohol use, cigarette smoking, HCV duration, and APRI and time-updated CD4 count and HIV RNA.


RESULTS
Overall, 55 (18%) participants developed an APRI ≥ 1.5 over 544 person-years of at-risk follow-up time; 18 (21%) women (incidence rate (IR)=14.0/100 PY; 7.5-20.4) and 37 (17%) men (IR=8.9/100 PY; 6.0-11.8). Women had more favourable profiles with respect to traditional risk factors for liver disease progression (younger, shorter duration of HCV infection and less alcohol use). Despite this, female sex was associated with a greater than two-fold increased risk of fibrosis progression (adjusted hazard rate (HR) =2.23; 1.22-4.08).


CONCLUSIONS
HIV-HCV co-infected women receiving antiretroviral therapy were at significantly greater risk of progressing to liver fibrosis as measured by APRI compared with men. Enhanced efforts to engage and treat co-infected women for HCV are needed.
First-generation students' academic engagement and retention

This study investigates differences in academic engagement and retention between first-generation and non-first-generation undergraduate students. Utilizing the Student Experience in the Research University survey of 1864 first-year students at a large, public research university located in the United States, this study finds that first-generation students have lower academic engagement (as measured by the frequency with which students interacted with faculty, contributed to class discussions, brought up ideas from different courses during class discussions, and asked insightful questions in class) and lower retention as compared to non-first-generation students. Recommendations that higher education faculty can follow to promote the academic engagement and retention of first-generation students are addressed.
A Comparative Study of Synchronous Current Control Schemes Based on FCS-MPC and PI-PWM for a Two-Motor Three-Phase Drive

A two-motor drive, supplied by a five-leg inverter, is considered in this paper. The independent control of machines with full dc-bus voltage utilization is typically achieved using an existing pulsewidth modulation (PWM) technique in conjunction with field-oriented control, based on PI current control. However, model predictive control (MPC), based on a finite number of control inputs [finite-control-set MPC (FCS-MPC)], does not utilize a pulsewidth modulator. This paper introduces three FCS-MPC schemes for synchronous current control in this drive system. The first scheme uses all of the available switching states. The second and third schemes are aimed at reducing the computational burden and utilize a reduced set of voltage vectors and a duty ratio partitioning principle, respectively. Steady-state and transient performances are analyzed and compared both against each other and with respect to the field-oriented control based on PI controllers and PWM. All analyses are experimental and use the same experimental rig and test conditions. Comparison of the predictive schemes leads to the conclusion that the first two schemes have the fastest transient response. The third scheme has a much smaller current ripple while achieving perfect control decoupling between the machines and is of low computational complexity. Nevertheless, at approximately the same switching loss, the PI-PWM control yields the lowest current ripple but with slower electrical transient response.
Loss of ‘Small-World’ Networks in Alzheimer's Disease: Graph Analysis of fMRI Resting-State Functional Connectivity

BACKGROUND
Local network connectivity disruptions in Alzheimer's disease patients have been found using graph analysis in BOLD fMRI. Other studies using MEG and cortical thickness measures, however, show more global long distance connectivity changes, both in functional and structural imaging data. The form and role of functional connectivity changes thus remains ambiguous. The current study shows more conclusive data on connectivity changes in early AD using graph analysis on resting-state condition fMRI data.


METHODOLOGY/PRINCIPAL FINDINGS
18 mild AD patients and 21 healthy age-matched control subjects without memory complaints were investigated in resting-state condition with MRI at 1.5 Tesla. Functional coupling between brain regions was calculated on the basis of pair-wise synchronizations between regional time-series. Local (cluster coefficient) and global (path length) network measures were quantitatively defined. Compared to controls, the characteristic path length of AD functional networks is closer to the theoretical values of random networks, while no significant differences were found in cluster coefficient. The whole-brain average synchronization does not differ between Alzheimer and healthy control groups. Post-hoc analysis of the regional synchronization reveals increased AD synchronization involving the frontal cortices and generalized decreases located at the parietal and occipital regions. This effectively translates in a global reduction of functional long-distance links between frontal and caudal brain regions.


CONCLUSIONS/SIGNIFICANCE
We present evidence of AD-induced changes in global brain functional connectivity specifically affecting long-distance connectivity. This finding is highly relevant for it supports the anterior-posterior disconnection theory and its role in AD. Our results can be interpreted as reflecting the randomization of the brain functional networks in AD, further suggesting a loss of global information integration in disease.