LLukas22/scidocs huggingface dataset:
Effect of perinatal short-course zidovudine on the clinical and virological manifestations of HIV-1 subtype E infection in infants.

BACKGROUND
The perinatal short-course zidovudine (ZDV) chemoprophylaxis that can reduce HIV-1 vertical transmission by 51% has been widely practiced in developing countries such as Thailand because of its simpler and less cost.


OBJECTIVES
To investigate the effects of short-course regimen of oral ZDV for prophylaxis of HIV-1 subtype E vertical transmission among 'break-through' HIV-1 infected infants.


STUDY DESIGN
The study analyzed clinical and virological outcomes of 80 infants, whose mothers received ZDV prophylaxis starting at 36 weeks gestation (group Z) and 37 infants whose mothers never received anti-retroviral drugs (group C), at the ages of 1-2, 4-6, and 12 months.


RESULTS
Of the 12 HIV-1 infected infants, 5/7 (71.4%) from group Z and 1/5 (20%) from group C progressed to a symptomatic clinical stage by the age 4-6 months. The intersample nucleotide distance of HIV-1 pol reverse transcriptase (RT) sequences of isolates collected at age of 1-2 months from group Z was significantly higher than that from group C (3.34 and 2.92%, P=0.02). All twelve virus isolates from infected infants were non syncytium inducing (NSI) and macrophage tropic strains; and 5/6 (83.3%) viruses from symptomatic infants were also T-tropic viruses. The symptomatic infants also had significantly higher HIV-1 nucleic acid quantitation than asymptomatic infants.


CONCLUSION
Our results preliminary suggested that infected infants who were perinatally exposed to ZDV may have a more rapid early disease progression with unfavorable viral manifestations than those without exposure to antiretroviral drug.
FKRP (826C>A) frequently causes limb-girdle muscular dystrophy in German patients.

M C Walter, J A Petersen, R Stucka, D Fischer, R Schröder, M Vorgerd, A Schroers, H Schreiber, C O Hanemann, U Knirsch, A Rosenbohm, A Huebner, N Barisic, R Horvath, S Komoly, P Reilich, W Müller-Felber, D Pongratz, J S Müller, E A Auerswald, H Lochmüller . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Effect of short-term heat acclimation on endurance time and skin blood flow in trained athletes

BACKGROUND
To examine whether short-term, ie, five daily sessions, vigorous dynamic cycling exercise and heat exposure could achieve heat acclimation in trained athletes and the effect of heat acclimation on cutaneous blood flow in the active and nonactive limb.


METHODS
Fourteen male badminton and table tennis athletes (age = 19.6 ± 1.2 years) were randomized into a heat acclimation (EXP, n = 7) or nonheat acclimation (CON, n = 7) group. For 5 consecutive days, the EXP group was trained using an upright leg cycle ergometer in a hot environment (38.4°C ± 0.4°C), while the CON group trained in a thermoneutral environment (24.1°C ± 0.3°C). For both groups, the training intensity and duration increased from a work rate of 10% below ventilatory threshold (VT) and 25 minutes per session on day 1, to 10% above VT and 45 minutes per session on day 5. Subjects performed two incremental leg cycle exercise tests to exhaustion at baseline and post-training in both hot and thermoneutral conditions. Study outcome measurements include: maximum oxygen uptake (VO2max); exercise heart rate (HR); O2 pulse; exercise time to exhaustion (tmax); skin blood flow in the upper arm (SkBFa) and quadriceps (SkBFq); and mean skin (Tsk).


RESULTS
The significant heat-acclimated outcome measurements obtained during high-intensity leg cycling exercise in the high ambient environment are: (1) 56%-100% reduction in cutaneous blood flow to the active limbs during leg cycling exercise; (2) 28% drop in cutaneous blood flow in nonactive limbs at peak work rate; (3) 5%-10% reduction in heart rate (HR); (4) 10% increase in maximal O2 pulse; and (5) 6.6% increase in tmax.


CONCLUSION
Heat acclimation can be achieved with five sessions of high-intensity cycling exercise in the heat in trained athletes, and redistribution of cutaneous blood flow in the skin and exercising muscle, and enhanced cardiovascular adaptations provide the heat-acclimated athletes with the capability to increase their endurance time in the hot environment.
The time problem

The notion of time in Ada is necessary since the language is intended for use in programming embedded real-time systems. In this chapter, we examine time related issues in Ada and their relation to our approach to benchmarking. There are two aspects of the time problem area that must be considered in performance evaluation. The first is a need for benchmark programs to evaluate the timing related features of the language. Secondly, the existence of timing support provides the basis for developing a method within the language for measuring benchmark execution times. In order to develop an accurate and reliable method for timing measurement, the support for timing provided by the language must be calibrated using benchmark programs. We discuss these two inter-related areas of the time problem in the paragraphs below, after first reviewing the notion of time present in Ada.
Problem behavior and urban, low-income youth: a randomized controlled trial of positive action in Chicago.

BACKGROUND
Youth problem behaviors remain a public health issue. Youth in low-income, urban areas are particularly at risk for engaging in aggressive, violent, and disruptive behaviors.


PURPOSE
To evaluate the effects of a school-based social-emotional learning and health promotion program on problem behaviors and related attitudes among low-income, urban youth.


DESIGN
A matched-pair, cluster RCT.


SETTING/PARTICIPANTS
Participants were drawn from 14 Chicago Public Schools over a 6-year period of program delivery with outcomes assessed for a cohort of youth followed from Grades 3 to 8. Data were collected from Fall 2004 to Spring 2010, and analyzed in Spring 2012.


INTERVENTION
The Positive Action program includes a scoped and sequenced K-12 classroom curriculum with six components: self-concept, social and emotional positive actions for managing oneself responsibly, and positive actions directed toward physical and mental health, honesty, getting along with others, and continually improving oneself. The program also includes teacher, counselor, family, and community training as well as activities directed toward schoolwide climate development.


MAIN OUTCOME MEASURES
Youth reported on their normative beliefs in support of aggression and on their bullying, disruptive, and violent behaviors; parents rated youths' bullying behaviors and conduct problems; schoolwide data on disciplinary referrals and suspensions were obtained from school records.


RESULTS
Multilevel growth-curve modeling analyses conducted on completion of the trial indicated that Positive Action mitigated increases over time in (1) youth reports of normative beliefs supporting aggressive behaviors and of engaging in disruptive behavior and bullying (girls only) and (2) parent reports of youth bullying behaviors (boys only). At study end-point, students in Positive Action schools also reported a lower rate of violence-related behavior than students in control schools. Schoolwide findings indicated positive program effects on both disciplinary referrals and suspensions. Program effect sizes ranged from -0.26 to -0.68.


CONCLUSIONS
These results extend evidence of the effectiveness of the Positive Action program to low-income, minority, urban school settings, and to middle school-aged youth.
The immune contexture in human tumours: impact on clinical outcome

Tumours grow within an intricate network of epithelial cells, vascular and lymphatic vessels, cytokines and chemokines, and infiltrating immune cells. Different types of infiltrating immune cells have different effects on tumour progression, which can vary according to cancer type. In this Opinion article we discuss how the context-specific nature of infiltrating immune cells can affect the prognosis of patients.
Medication adherence and racial differences in A1C control.

OBJECTIVE
The purpose of this study was to examine medication adherence and other self-management practices as potential determinants of higher glycemic risk among black relative to white patients.


RESEARCH DESIGN AND METHODS
We used a retrospective, longitudinal repeated-measures design to model the contribution of medication adherence to black-white differences in A1C among type 2 diabetic patients at a large multispecialty group practice. We identified 1,806 adult (aged >/=18 at diagnosis) patients (467 black and 1,339 white) with newly initiated oral hypoglycemic therapy between 1 December 1994 and 31 December 2000. Race was identified using an electronic medical record and patient self-report. Baseline was defined as the 13 months preceding and included the month of therapy initiation. All patients were required to have at least 12 months of follow-up.


RESULTS
At initiation of therapy, black patients had higher average A1C values compared with whites (9.8 vs. 8.9, a difference of 0.88; P < 0.0001). Blacks had lower average medication adherence during the first year of therapy (72 vs. 78%; P < 0.0001). Although more frequent medication refills were associated with lower average A1C values, adjustment for adherence did not eliminate the black-white gap.


CONCLUSIONS
We found persistent racial differences in A1C that were not explained by differences in medication adherence. Our findings suggest that targeting medication adherence alone is unlikely to reduce disparities in glycemic control in this setting. Further research is needed to explore possible genetic and environmental determinants of higher A1C among blacks at diagnosis, which may represent a critical period for more intensive intervention.
Tactics of Adversarial Attack on Deep Reinforcement Learning Agents

We introduce two tactics to attack agents trained by deep reinforcement learning algorithms using adversarial examples, namely the strategicallytimed attack and the enchanting attack. In the strategically-timed attack, the adversary aims at minimizing the agent’s reward by only attacking the agent at a small subset of time steps in an episode. Limiting the attack activity to this subset helps prevent detection of the attack by the agent. We propose a novel method to determine when an adversarial example should be crafted and applied. In the enchanting attack, the adversary aims at luring the agent to a designated target state. This is achieved by combining a generative model and a planning algorithm: while the generative model predicts the future states, the planning algorithm generates a preferred sequence of actions for luring the agent. A sequence of adversarial examples is then crafted to lure the agent to take the preferred sequence of actions. We apply the two tactics to the agents trained by the state-of-the-art deep reinforcement learning algorithm including DQN and A3C. In 5 Atari games, our strategically-timed attack reduces as much reward as the uniform attack (i.e., attacking at every time step) does by attacking the agent 4 times less often. Our enchanting attack lures the agent toward designated target states with a more than 70% success rate. Videos are available at http: //yclin.me/adversarial_attack_RL/.
Bronchodilator response as a hallmark of uncontrolled asthma: a randomised clinical trial.

INTRODUCTION
The goal of this study is to determine whether bronchodilator (BD) response can be used as a reliable measure of asthma control by analyzing the effects of a short course of oral corticosteroids (OC) or placebo (P) on spirometry, sputum cytology and BD response in controlled asthma patients scoring less than 1.5 on the ACQ5.


METHODS
Seventy patients with moderate to severe asthma who were undergoing combination therapy and were considered to be controlled based on ACQ5 scores, but who exhibited persistent positive BD response, were randomly assigned to two groups, one receiving OC and the other P. Patients were evaluated before and after 2 weeks of treatment. Intervention response (comparison of FEV(1) before and after OC or P treatment) was used as a measure of intervention efficacy, with values equal to or greater than 200 mL considered positive.


RESULTS
Patients who received OC showed significant improvement in FEV(1), and no longer exhibited a positive BD response. Those in the P group showed no change. In addition, sputum eosinophil counts significantly decreased in the OC group.


CONCLUSIONS
BD response can be used as a reliable measure of asthma control. This study suggests that ACQ5 scores alone are not sufficient to fully assess asthma control, and that BD response should be included as an essential measurement in any algorithm of asthma control evaluation.
Abnormal Early Cleavage Events Predict Early Embryo Demise: Sperm Oxidative Stress and Early Abnormal Cleavage

Human embryos resulting from abnormal early cleavage can result in aneuploidy and failure to develop normally to the blastocyst stage. The nature of paternal influence on early embryo development has not been directly demonstrated although many studies have suggested effects from spermatozoal chromatin packaging, DNA damage, centriolar and mitotic spindle integrity, and plasma membrane integrity. The goal of this study was to determine whether early developmental events were affected by oxidative damage to the fertilizing sperm. Survival analysis was used to compare patterns of blastocyst formation based on P2 duration. Kaplan-Meier survival curves demonstrate that relatively few embryos with short (<1 hr) P2 times reached blastocysts, and the two curves diverged beginning on day 4, with nearly all of the embryos with longer P2 times reaching blastocysts by day 6 (p < .01). We determined that duration of the 2nd to 3rd mitoses were sensitive periods in the presence of spermatozoal oxidative stress. Embryos that displayed either too long or too short cytokineses demonstrated an increased failure to reach blastocyst stage and therefore survive for further development. Although paternal-derived gene expression occurs later in development, this study suggests a specific role in early mitosis that is highly influenced by paternal factors.
Soil clay content and fire frequency affect clustering in trees in South African savannas

In this paper, we investigate which factors determine tree clustering in Southern African savannas. This was tested by measuring clustering of trees using the T-squared sampling method in plots of the Kruger National Park experimental burning programme in South Africa. Fire return interval is the main treatment in these plots, but also several auxiliary determining parameters like clay content in the soil, diameter of tree canopies, understorey composition, tree species diversity and average annual rainfall were measured while sampling. In the Kruger National Park 48 plots distributed over four different landscape types and with three different burning treatments (never, once every 3 y and annually) were sampled. First, we related the clustering of trees to these environmental variables. When looking at the most abundant species in each plot, the analysis revealed that clustering is mainly correlated with clay content in the soil. This analysis also showed that fire frequency had a positive effect on the clustering of tree species that are not very abundant. We suggest that less abundant species might be less resistant to fire and therefore adopt a mechanism of clustering to exclude grass fires under their canopy. Finally, we tested the effect of clustering on the impact of fire on trees by analysing the relationship between the distance of a tree to its nearest neighbour and its canopy diameter. We found that clustering reduces the damaging effect of fire on trees. Our study contributes to understanding of savanna functioning by showing which processes are relevant in the distribution of savanna trees.
Stakeholder welfare and firm value

Using data from the independent social choice investment advisory firm Kinder, Lydenberg, Domini (KLD), we construct a stakeholder welfare score measuring the extent to which firms meet the expectation of their non-shareholder stakeholders (such as employees, customers, communities, and environment), and find it to be associated with positive valuation effects: an increase of 1 in the stakeholder welfare score leads to an increase of 0.587 in Tobin’s Q. Furthermore, the valuation effects vary across stakeholders and the aforementioned positive effects are driven by firms’ performance on employee relations and environmental issues. These results suggest that stakeholder welfare (in particular, employee welfare and environmental performance) represents intangibles (such as reputation or human capital) crucial for shareholder value creation rather than private benefits managers pursue for their own social or economic needs. 2010 Elsevier B.V. All rights reserved.
Contrasting Opposing Views of News Articles on Contentious Issues

We present disputant relation-based method for classifying news articles on contentious issues. We observe that the disputants of a contention are an important feature for understanding the discourse. It performs unsupervised classification on news articles based on disputant relations, and helps readers intuitively view the articles through the opponent-based frame. The readers can attain balanced understanding on the contention, free from a specific biased view. We applied a modified version of HITS algorithm and an SVM classifier trained with pseudo-relevant data for article analysis.
Specifying Constraints for Detecting Inconsistencies in A Conceptual Graph Knowledge Base

This﻿ paper﻿ proposes﻿ a﻿ strategy﻿ for﻿ representing﻿ constraints﻿ in﻿ a﻿ conceptual﻿ graph﻿ knowledge﻿base.﻿We﻿describe﻿a﻿set﻿of﻿techniques﻿for﻿using﻿these﻿constraints﻿to﻿detect﻿ inconsistencies﻿in﻿a﻿knowledge﻿base﻿by﻿finding﻿sets﻿of﻿nodes﻿that﻿are﻿inconsistent﻿with﻿ these﻿constraints.﻿The﻿detection﻿method﻿is﻿designed﻿to﻿be﻿efficient.﻿An﻿algorithm﻿was﻿ developed﻿and﻿analyzed﻿and﻿its﻿computational﻿complexity﻿was﻿found﻿to﻿be﻿polynomial﻿ with﻿respect﻿to﻿knowledge﻿base﻿size﻿and﻿number﻿of﻿child﻿nodes﻿for﻿each﻿constraint﻿node. KeywoRDS Conceptual Graph, Graph Constraints, Inconsistency Detection, Knowledge Base
5-HTTLPR genotype and anxiety-related personality traits: a meta-analysis and new data.

We investigated the strength of evidence for association of the 5-HTTLPR polymorphism and the personality trait of Harm Avoidance. We used new primary data from a large sample of adults drawn from the Finnish population. We also applied meta-analytic techniques to synthesize existing published data. The large number of studies of the 5-HTTLPR polymorphism allowed us to apply a formal test of publication bias, as well as formally investigate the impact of potential moderating factors such as measurement instrument. Univariate ANOVA of primary data (n = 3,872), with 5-HTTLPR genotype as a between-groups factor, indicated no evidence of association with Harm Avoidance (P = 0.99). Meta-analysis indicated no evidence of significant association of 5-HTTLPR with Harm Avoidance (d = 0.02, P = 0.37), or EPQ Neuroticism (d = 0.01, P = 0.71), although there was evidence of association with NEO Neuroticism (d = 0.18, P < 0.001). Our analyses indicate that the 5-HTTLPR variant is not associated with Harm Avoidance. Together with our previous analyses of a large sample of participants with extreme Neuroticism scores (defined by the EPQ), we have data that excludes a meaningful genetic effect of the 5-HTTLPR on two measures of anxiety-related personality traits. There remains the possibility that the variant influences the NEO personality questionnaire measure of Neuroticism. However, a large, well-powered primary study is required to test this hypothesis directly and adequately.
Auricular acupuncture with seed or pellet attachments for primary insomnia: a systematic review and meta-analysis

BACKGROUND
Primary insomnia is a common health issue in the modern world. We conducted a systematic review of the auricular therapy, aiming to evaluate whether there are advantages of auricular acupuncture with seed or pellet attachments for the treatment of primary insomnia.


METHODS
A search of relevant literatures was performed on major medical databases, including Medline, Embase, CENTRAL, CBM, CNKI, VIP, Wanfang Data and so on. Risk of bias evaluation, meta-analysis, sensitivity analysis and evidence rating of all extracted information were conducted also.


RESULTS
A total of 1381 records were identified, with 15 studies deemed eligible for the present review. Meta-analyses were conducted in two comparisons separately: participants received auricular acupuncture were more likely to make an improvement in clinical effective rate (RR = 1.40, 95% CI 1.07 to 1.83), sleep duration (MD = 56.46, 95% CI 45.61 to 67.31), sleep efficiency(MD = 12.86, 95% CI 9.67 to 16.06), global score on PSQI (MD = -3.41, 95% CI -3.93 to -2.89), number of awakenings( MD = -3.27, 95% CI -6.30 to -0.25) and sleep onset latency(MD = -10.35, 95% CI -14.37 to -6.33) when compared to sham auricular acupuncture or placebo; while in auricular acupuncture VS medications comparison, a better effective rate (RR = 1.24, 95% CI 1.15 to 1.34), better sleep efficiency(MD = 21.44, 95% CI 16.30 to 26.58), lower PSQI score (MD = -3.62, 95% CI -4.59 to -2.65) and less adverse effect (RR = 0.11, 95% CI 0.04 to 0.26) can be seen also in auricular acupuncture group. Although these results suggested benefits of auricular acupuncture, the overall quality of evidence rated by the GRADE system was low.


CONCLUSION
Statistical analyses of the outcomes revealed a positive effect of auricular acupuncture for primary insomnia. Nonetheless, considering the poor methodological quality, insufficient sample size and possible publication bias, current evidence is not yet adequate to provide a strong support for the use of auricular acupuncture in the treatment of primary insomnia. More strictly designed clinical studies will be needed to obtain a more explicit conclusion.