LLukas22/scidocs huggingface dataset:
18.2 Highly-linear integrated magnetic-free circulator-receiver for full-duplex wireless

A fundamental challenge of full-duplex (FD) wireless [1] is the implementation of low-cost, small-form-factor, integrated shared-antenna (ANT) interfaces with low loss, low noise, high TX-RX isolation, and large TX power handling. Providing more TX-RX isolation in the ANT interface that is robust to environmental variations lowers the self-interference cancellation (SIC) and dynamic range required in the RF, analog baseband (BB), and digital domains. Reciprocal shared-ANT interfaces, such as electrical-balance duplexers [2], fundamentally feature at least 3dB loss (practically >4dB). A non-reciprocal active shared-ANT duplexing scheme was demonstrated in [3], but such active approaches are limited in their maximum supported TX power (−17.3dBm in [3] limited by RX compression) and noise performance. An integrated FD RX with a magnetic-free non-reciprocal passive circulator was demonstrated in [4]. Despite the circulator's low loss and relatively high linearity, the RX could only handle up to −7dBm TX power due to limited circulator isolation and RX LNA linearity. NF under cancellation was also as high as 10.9dB.
Iron chelation by cranberry juice and its impact on Escherichia coli growth.

The various health benefits of Vaccinium macrocarpon (cranberry) are well documented and have been attributed mainly to its antioxidant capacity and anti-adhesive activity. Several different mechanisms have been proposed to explain the possible role of cranberries, cranberry juice, and cranberry extracts in inhibiting bacterial growth. These mechanisms of action (i.e., inhibition of the microbial growth) have not been thoroughly studied. Here, we took advantage of current advances in microarray technology and used GeneChip® Escherichia coli genome 2.0 arrays to gain insight into the molecular mechanisms involved in the impact of cranberry juice on the properties of E. coli growth. The inclusion of cranberry juice in bacterial growth media was found to significantly impact the doubling time of E. coli. The gene expression results revealed altered expression of genes associated with iron transport and essential metabolic enzymes as well as with adenosine triphosphate (ATP) synthesis and fumarate hydratase in these cultures. The altered expression of genes associated with iron transport was consistent with the strong iron chelating capability of proanthocyanidins, a major constituent of cranberry juice. The iron depletion effect was confirmed by adding exogenous iron to the growth media. This addition partially reversed the inhibitory effect on bacterial growth observed in the presence of cranberry juice/extracts.
Factors affecting esophageal motility in gastroesophageal reflux disease.

BACKGROUND
There are conflicting data concerning the effect of gastroesophageal reflux disease (GERD) on esophageal motor function.


HYPOTHESIS
Duration of GERD might affect severity of symptoms, grade of esophageal mucosal injury, and esophageal motor behavior.


DESIGN
Retrospective study of a defined cohort.


SETTINGS
Two referral centers, one of them academic, for esophageal gastrointestinal motility disorders.


PATIENTS
One hundred forty-seven patients with documented GERD.


MAIN OUTCOME MEASURES
Symptoms, grade of mucosal injury on esophagoscopy, esophageal manometry, ambulatory esophageal pH monitoring, and esophagogram.


RESULTS
Patients with GERD had significantly decreased lower esophageal sphincter resting pressure (P =.02), lower amplitude of esophageal peristalsis at all levels of measurement (P<.001), and more delayed esophageal transit (P =.007) compared with control subjects. Patients with dysphagia, severe esophagitis, and Barrett esophagus presented with a longer history of the disease, significantly worse esophageal motor function (P<.01), and more prolonged esophageal transit than patients without the above features of the disease. Impairment of esophageal peristalsis and lower esophageal sphincter resting pressure were significantly inversely related to the duration of the disease (P<.001). Also, delay of esophageal transit was significantly related to the duration of the disease (P =.002) and inversely related to the amplitude of esophageal peristalsis (P<.001). Unlike the manometric variables, the extent of reflux, as assessed by ambulatory 24-hour esophageal pH monitoring, was not related to the duration of the disease.


CONCLUSION
A long history of GERD is more commonly associated with presence of dysphagia, delayed esophageal transit, severe esophagitis, presence of Barrett esophagus, and impaired esophageal motility.
Comparison of calcium acetate with calcium carbonate as phosphate binder in patients on maintenance haemodialysis.

BACKGROUND
Hyperphosphatemia is common in end-stage renal disease patients. Objective of this study is to compare the hypercalcaemic effect and phosphate binding power of calcium acetate and calcium carbonate in end-stage renal disease patients on maintenance haemodialysis.


METHODS
This randomised control trial was conducted in four phases with calcium acetate or calcium carbonate. Sixty-four patients on haemodialysis were randomly divided into 2 groups. After a washout period of 2 weeks, each group was given calcium acetate or calcium carbonate for 2 months. After another washout period the patients were crossed over and again received these drugs for 2 months. Serum Calcium, phosphate, and albumin were analysed on Selectra E auto analyser at completion of each phase of study. Hypercalcaemic effect was defined as serum calcium > 2.54 mmol/l, and phosphate binding power as serum phosphate < 1.61 mmol/l.


RESULTS
Forty-one patients completed the study. Though lower dose of calcium acetate was used, it resulted in equally good control of hyperphosphatemia as compared with calcium carbonate therapy [1.37 mmol/l (SD 0.33) vs. 1.46 mmol/l (SD 0.34), p = 0.16]. Incidence of hypercalcaemia was higher with calcium carbonate therapy (2.73 +/- 0.67 mmol/l vs. 2.32 +/- 0.28 mmol/l, p < 0.01). Both drugs were well tolerated, but patients more frequently complained of muscle cramps while taking calcium acetate.


CONCLUSIONS
It is concluded that calcium acetate has similar effect on serum phosphate levels as compared to calcium carbonate in patients on maintenance haemodialysis. However, calcium acetate results in lesser frequency of hypercalcaemia as compared to calcium carbonate. Tolerance to both drugs was similar, though patients complained of more muscle cramps while taking calcium acetate.
The hyperuniverse program

The Hyperuniverse Program is a new approach to set-theoretic truth which is based on justifiable principles and leads to the resolution of many questions independent from ZFC. The purpose of this paper is to present this program, to illustrate its mathematical content and implications, and to discuss its philosophical assumptions.
Ridge collision and in situ greenstones in accretionary complexes: An example from the Late Cretaceous Ryukyu Islands and southwest Japan margin

Abstract Melange units containing greenstones are common throughout the Cretaceous-Miocene Shimanto Supergroup in the Ryukyu Is and southwest Japan. Most greenstones in the accretionary complex originated in oceanic spreading ridges and seamounts, and they formed far from the convergent margin. Some melange-like units in the supergroup, however, contain greenstones that were extruded upon and intruded into unconsolidated fine-grained terrigenous clastic sediments. It is inferred that eruption of the in situ greenstones resulted from igneous activity in the trench area. Geochemical signatures indicate that the greenstone protoliths were similar to mafic lavas generated at spreading ridges. Fossil ages of the strata containing in situ greenstones become younger over a distance of 1300 km eastward from Amami-Oshima (Cenomanian-Turonian) in the Ryukyu Is to central Japan (Late Maestrichtian-earliest Paleocene), implying that a site of igneous activity in the trench area migrated eastward along the Ryukyu Is and southwest Japan margin. Plate reconstructions of the northwest Pacific Ocean suggest the presence of the Kula-Pacific ridge near Late Cretaceous to early Paleogene Japan. In this context, it is suggested that the greenstones formed in response to Kula-Pacific ridge-forearc collision. 
 
Ancient ridge-forearc collisions are best recognized by the presence of mid-ocean ridge basalt (MORB) extruded on sediments inferred to have accumulated in the trench area. Diachronous occurrences of the strata associated with these MORB in an orogenic belt are useful for documenting the ridge collision through time.
Challenges of Agile Development and Implementation in a Developing Country: A Zambia Case Study

Corresponding author: Douglas Kunda Mulungushi University, School of Science, Engineering and Technology, Kabwe, Zambia Email: dkunda@mu.edu.zm Abstract: Agile development is a software development process that advocates adaptive planning, early delivery, evolutionary development and continuous betterment and supports rapid and flexible response to change. The purpose of Agile development is minimize project failure through customer interactions and responding to change. However, Agile development is vulnerable to failure because of a number of factors and these factors can be categorized under four dimensions, namely; organizational, people, process and technical. This paper reports the result of a study aimed at identifying factors that influence success and/or failure of Agile development in a developing country, Zambia. A multiple case study approach and grounded theory approach was used for this case study. The study shows that there are challenges that are unique to developing countries and therefore measures should be developed to address these unique problems when implementing Agile projects in developing countries.
Emotion processing and social participation following stroke: study protocol

BACKGROUND
The International Classification of Functioning, Disability and Health (ICF) defines participation as a person's performance in life situations, including the size of social networks, and satisfaction with social contacts. Stroke survivors are known to experience a reduction in the number of their social networks and contacts, which cannot be explained solely in terms of activity limitations caused by physical impairment. Problems of emotional processing, including impaired mood, emotion regulation and emotion perception, are known to occur following stroke and can detrimentally influence many aspects of social interaction and participation. The aim of this study is to investigate whether emotion processing impairments predict stroke survivors' restricted social participation, independent of problems with activity limitation.


METHODS/DESIGN
We aim to recruit 125 patients admitted to NHS Grampian with a confirmed diagnosis of stroke. All participants will be assessed on measures of emotion processing, social participation and activity limitation at approximately one month post stroke and again at approximately one year post stroke in order to assess change over time.


DISCUSSION
It is important to develop a greater understanding of the emotional factors which may underlie key social deficits in stroke recovery in an ageing population where stroke is one of the leading causes of severe, complex disability. This research may enable us to identify those who are risk of participation restriction and target them in the acute stroke phase of stroke so that adverse outcome is avoided and rehabilitation potential is fulfilled.
Development of all CD4 T lineages requires nuclear factor TOX

CD8(+) cytotoxic and CD4(+) helper/inducer T cells develop from common thymocyte precursors that express both CD4 and CD8 molecules. Upon T cell receptor signaling, these cells initiate a differentiation program that includes complex changes in CD4 and CD8 expression, allowing identification of transitional intermediates in this developmental pathway. Little is known about regulation of these early transitions or their specific importance to CD4 and CD8 T cell development. Here, we show a severe block at the CD4(lo)CD8(lo) transitional stage of positive selection caused by loss of the nuclear HMG box protein TOX. As a result, CD4 lineage T cells, including regulatory T and CD1d-dependent natural killer T cells, fail to develop. In contrast, functional CD8(+) T cells develop in TOX-deficient mice. Our data suggest that TOX-dependent transition to the CD4(+)CD8(lo) stage is required for continued development of class II major histocompatibility complex-specific T cells, regardless of ultimate lineage fate.
Effects of suvorexant, an orexin receptor antagonist, on breathing during sleep in patients with chronic obstructive pulmonary disease.

OBJECTIVES
There is a general concern that hypnotic medications in patients with respiratory disorders have the potential to decrease respiratory effort and blunt the arousal response to hypoxemia which may lead to sleep breathing disorders. We investigated whether suvorexant, an orexin receptor antagonist approved for treatment of insomnia at a maximum daily dose of 20 mg in the US, causes sleep breathing disorders in patients with chronic obstructive pulmonary disease (COPD).


DESIGN
This was a randomized, double-blind, placebo-controlled, 2-period, cross-over, study performed in 9 sleep laboratories/clinical research units in the United States. The participants were 25 COPD patients aged 39-72 y with mild-to-moderate airflow limitation based on GOLD spirometry criteria. In each period, patients received suvorexant (40 mg in <65 y-olds; 30 mg in ≥65 y-olds) or placebo for four consecutive nights. Respiratory function during sleep was measured by oxygen saturation using pulse oximetry (SpO2, primary endpoint) and Apnea Hypopnea Index (AHI, secondary endpoint). The study was powered to rule out a difference between treatments of -2 percentage points in SpO2 on Day 4.


RESULTS
There was no treatment effect following single and multiple doses of suvorexant on mean SpO2 during total sleep time (Day 1: suvorexant = 93.14%, placebo = 93.24%, difference = -0.10 [90% CI: -0.50, 0.31]; Day 4: suvorexant = 93.38%, placebo = 92.99%, difference = 0.39 [90% CI: -0.12, 0.91]). There was no clinically meaningful increase in mean AHI by suvorexant compared with placebo on Day 1 (difference = 0.72 [90% CI: -0.60, 2.04]) or Day 4 (difference = 2.05 [90% CI: 0.33, 3.77]).


CONCLUSIONS
These data do not suggest an overt respiratory depressant effect with 30-40 mg daily doses of suvorexant, up to twice the maximum recommended dose for treating insomnia in the US, in patients with mild-to-moderate COPD. Trial registration Clinicaltrials.gov identifier: NCT01293006.
Correcting for contact geometry in Seebeck coefficient measurements of thin film devices

Driven by promising recent results, there has been a revived interest in the thermoelectric properties of organic (semi)conductors. Concomitantly, there is a need to probe the Seebeck coefficient S of modestly conducting materials in thin film geometry. Here we show that geometries that seem desirable from a signal-to-noise perspective may induce systematic errors in the measured value of S, Sm, by a factor 3 or more. The enhancement of Sm by the device geometry is related to competing conduction paths outside the region between the electrodes. We derive a universal scaling curve that allows correcting for this and show that structuring the semiconductor is not needed for the optimal electrode configuration, being a set of narrow, parallel strips. 2014 Elsevier B.V. All rights reserved.
IL-17 mRNA in sputum of asthmatic patients: linking T cell driven inflammation and granulocytic influx?

BACKGROUND
The role of Th2 cells (producing interleukin (IL-)4, IL-5 and IL-13) in allergic asthma is well-defined. A distinct proinflammatory T cell lineage has recently been identified, called Th17 cells, producing IL-17A, a cytokine that induces CXCL8 (IL-8) and recruits neutrophils. Neutrophilic infiltration in the airways is prominent in severe asthma exacerbations and may contribute to airway gland hypersecretion, bronchial hyper-reactivity and airway wall remodelling in asthma.


AIM
to study the production of IL-17 in asthmatic airways at the mRNA level, and to correlate this with IL-8 mRNA, neutrophilic inflammation and asthma severity.


METHODS
We obtained airway cells by sputum induction from healthy individuals (n = 15) and from asthmatic patients (n = 39). Neutrophils were counted on cytospins and IL-17A and IL-8 mRNA expression was quantified by real-time RT-PCR (n = 11 controls and 33 asthmatics).


RESULTS
Sputum IL-17A and IL-8 mRNA levels are significantly elevated in asthma patients compared to healthy controls. IL-17 mRNA levels are significantly correlated with CD3gamma mRNA levels in asthmatic patients and mRNA levels of IL-17A and IL-8 correlated with each other and with sputum neutrophil counts. High sputum IL-8 and IL-17A mRNA levels were also found in moderate-to-severe (persistent) asthmatics on inhaled steroid treatment.


CONCLUSION
The data suggest that Th17 cell infiltration in asthmatic airways links T cell activity with neutrophilic inflammation in asthma.
Big-data applications in the government sector

In the same way businesses use big data to pursue profits, governments use it to promote the public good.
Chinese immigrant parents’ vaccination decision making for children: a qualitative analysis

BACKGROUND
While immunization coverage rates for childhood routine vaccines in Hong Kong are almost 100%, the uptake rates of optional vaccines remain suboptimal. Understanding parental decision-making for children's vaccination is important, particularly among minority groups who are most vulnerable and underserved. This study explored how a subsample of new immigrant mothers from mainland China, a rapidly-growing subpopulation in Hong Kong, made decisions on various childhood and adolescent vaccines for their offspring, and identified key influences affecting their decision making.


METHODS
Semi-structured in-depth interviews were conducted with 23 Chinese new immigrant mothers recruited by purposive sampling. All interviews were audio-taped, transcribed and analyzed using a Grounded Theory approach.


RESULTS
Participants' conversation revealed five underlying themes which influenced parents' vaccination decision-making: (1) Institutional factors, (2) Insufficient vaccination knowledge and advice, (3) Affective impacts on motivation, (4) Vaccination barriers, and (5) Social influences. The role of social norms appeared overwhelmingly salient influencing parents' vaccination decision making. Institutional factors shaped parent's perceptions of vaccination necessity. Fear of vaccine-targeted diseases was a key motivating factor for parents adopting vaccination. Insufficient knowledge about vaccines and targeted diseases, lack of advice from health professionals and, if provided, suspicions regarding the motivations for such advice were common issues. Vaccination cost was a major barrier for many new immigrant parents.


CONCLUSIONS
Social norms play a key role influencing parental vaccination decision-making. Insight gained from this study will help inform healthcare providers in vaccination communication and policymakers in future vaccination programme.
Automating acceptance tests for sensor- and actuator-based systems on the example of autonomous vehicles

vii
Increased infiltration of activated tumor-infiltrating lymphocytes after high intensity focused ultrasound ablation of human breast cancer.

BACKGROUND
Previous studies have shown that high intensity focused ultrasound (HIFU) ablation can induce a distinct inflammatory reaction with marked infiltration of lymphocytes after direct tumor destruction. In this study, we investigated the status of tumor-infiltrating lymphocytes (TILs) after HIFU ablation of human breast cancer and explored mechanisms that may be involved in HIFU-triggered, antitumor immune response.


METHODS
A total of 48 female patients with biopsy-proven breast cancer were divided randomly into 1 of 2 groups: control group (n = 25), in which only modified radical mastectomy was performed, or HIFU group (n = 23), in which HIFU ablation of the primary breast cancer was performed prior to modified radical mastectomy. Using semiquantitative immunohistochemical analysis, tumor-infiltrating T lymphocytes and subsets, B lymphocytes, and natural killer (NK) cells were assessed in all patients. Expression of Fas ligand (FasL), granzyme, and perforin on TILs was also studied in both groups.


RESULTS
TILs infiltrated along the margins of the ablated region in all HIFU-treated neoplasms, and the numbers of tumor-infiltrating CD3, CD4, CD8, CD4/CD8, B lymphocytes, and NK cells was increased significantly in the HIFU group. The number of FasL(+), granzyme(+), and perforin(+) TILs was significantly greater in the HIFU group than in the control group.


CONCLUSION
HIFU ablation induced marked infiltration of CD3, CD4, CD8, B lymphocytes, and NK cells in the treated breast lesions. The number of FasL(+), granzyme(+), and perforin(+) TILs was significantly increased after HIFU treatment.
Transmuted modified Weibull distribution: a generalization of the modified Weibull probability distribution

This paper introduces a transmuted modified Weibull distribution as an important competitive model which contains eleven life time distributions as special cases. We generalized the three parameter modified Weibull distribution using the quadratic rank transmutation map studied by Shaw et al. [12] to develop a transmuted modified Weibull distribution. The properties of the transmuted modified Weibull distribution are discussed. Least square estimation is used to evaluate the parameters. Explicit expressions are derived for the quantiles. We derive the moments and examine the order statistics. We propose the method of maximum likelihood for estimating the model parameters and obtain the observed information matrix. This model is capable of modeling of various shapes of aging and failure criteria. 2010 Mathematics Subject Classifications: 90B25; 62N05