LLukas22/scidocs huggingface dataset:
Standard graft-versus-host disease prophylaxis with or without anti-T-cell globulin in haematopoietic cell transplantation from matched unrelated donors: a randomised, open-label, multicentre phase 3 trial.

BACKGROUND
Graft-versus-host disease (GVHD) is a major cause of morbidity and mortality after allogeneic haematopoietic cell transplantation from unrelated donors. Anti-T-cell globulins (ATGs) might lower the incidence of GVHD. We did a prospective, randomised, multicentre, open-label, phase 3 trial to compare standard GVHD prophylaxis with ciclosporin and methotrexate with or without anti-Jurkat ATG-Fresenius (ATG-F).


METHODS
Between May 26, 2003, and Feb 8, 2007, 202 patients with haematological malignancies were centrally randomly assigned using computer-generated centre-stratified block randomisation between treatment groups receiving ciclosporin and methotrexate with or without additional ATG-F. One patient in the ATG-F group did not undergo transplantation, thus 201 patients who underwent transplantation with peripheral blood (n=164; 82%) or bone marrow (n=37; 18%) grafts from unrelated donors after myeloablative conditioning were included in the full analysis set, and were analysed according to their randomly assigned treatment (ATG-F n=103, control n=98). The primary endpoint was severe acute GVHD (aGVHD) grade III-IV or death within 100 days of transplantation. The trial is registered with the numbers DRKS00000002 and NCT00655343.


FINDINGS
The number of patients in the ATG-F group who had severe aGVHD grade III-IV or who died within 100 days of transplantation was 12 and 10 (21.4%, 95% CI 13.4-29.3), respectively, compared with 24 and nine (33.7%, 24.3-43.0) patients, respectively, in the control group (adjusted odds ratio 0.59, 95% CI 0.30-1.17; p=0.13). The cumulative incidence of aGVHD grade III-IV was 11.7% (95% CI 6.8-19.8) in the ATG-F group versus 24.5% (17.3-34.7) in the control group (adjusted hazard ratio [HR] 0.50, 95% CI 0.25-1.01; p=0.054), and cumulative incidence of aGVHD grade II-IV was 33.0% (n=34; 95% CI 25.1-43.5) in the ATG-F group versus 51.0% (n=50; 95% CI 42.0-61.9) in the control group (adjusted HR 0.56, 0.36-0.87; p=0.011). The 2-year cumulative incidence of extensive chronic GVHD was 12.2% (n=11; 95% CI 7.0-21.3) versus 42.6% (n=34; 95% CI 33.0-55.0; adjusted HR 0.22, 0.11-0.43; p<0.0001). There were no differences between treatment groups with regard to relapse, non-relapse mortality, overall survival, and mortality from infectious causes.


INTERPRETATION
The addition of ATG-F to GVHD prophylaxis with ciclosporin and methotrexate resulted in decreased incidence of acute and chronic GVHD without an increase in relapse or non-relapse mortality, and without compromising overall survival. The use of ATG-F is safe for patients who are going to receive a haematopoietic cell transplantation from matched unrelated donors.


FUNDING
Fresenius Biotech GmbH.
Laboratory testing of the Pressio intracranial pressure monitor.

OBJECTIVE
The Sophysa Pressio (Sophysa Ltd., Orsay, France) is a new intracranial pressure monitoring system. This study aimed to evaluate its accuracy and compare it with the popular Codman intracranial pressure transducer (Codman/Johnson & Johnson, Raynham, MA) in vitro.


METHODS
A computerized rig was used to test the Pressio and Codman transducers simultaneously. Properties that were tested included drift over 7 days, the effect of temperature on drift, frequency response, the accuracy of measurement of static and pulsatile pressures, and connectivity of the system.


RESULTS
Long-term (7 d) relative zero drift was less than 0.05 mmHg. The temperature drift was low (0.3 mmHg/207C). Absolute static accuracy was better than 0.5 mmHg over the range of 0 to 100 mmHg. Pulse waveform accuracy, relative to the Codman transducer, was better than 0.2 mmHg over the range of 1 to 20 mmHg. The frequency bandwidth of the Pressio transducer was 22 Hz. The Pressio monitor can transmit data directly to an external computer without the use of a pressure bridge amplifier.


CONCLUSION
The new Pressio transducer proved to be accurate for measuring static and dynamic pressure during in vitro evaluation.
Relationship between care gaps and projected life expectancy after acute myocardial infarction.

BACKGROUND
Higher-risk patients may not receive evidence-based therapy because of limited life expectancy, which is a composite measure that encompasses many patient factors, including age, frailty, and comorbidities. In this study, we evaluated the extent to which treatment care gaps can be explained by a difference in projected life expectancy.


METHODS AND RESULTS
An observational cohort study was conducted on acute myocardial infarction patients hospitalized in Ontario, Canada. Projected life expectancy was estimated using actual survival data with extrapolation using proportional hazard models adjusting for important covariates. The relationship between projected life expectancy with statins and reperfusion therapy was examined using generalized linear models. Among the 7001 acute myocardial infarction patients, 84.3% were prescribed statins and 72.9% were treated with reperfusion therapy. When projected life expectancy was <10 years, the likelihood of receiving either treatment declined progressively with reduction in life expectancy (P<0.001). At the 25th percentile of projected life expectancies, the likelihood of receiving a statin decreased by 1.4% (95% confidence interval, 1.0-1.8%), and acute reperfusion therapy decreased by 2.6% (95% confidence interval, 1.8-3.3%) for each year decline in projected life expectancy.


CONCLUSIONS
Life expectancy of a patient strongly influences evidence-based treatment in acute myocardial infarction. It was seen not only among patients with limited life expectancies but also among those with many years to live. Treatment care gaps may reflect clinicians' synthesis about frailty and life-expectancy gains.
Expert Recommendation via Tensor Factorization with Regularizing Hierarchical Topical Relationships

Knowledge acquisition and exchange are generally crucial yet costly for both businesses and individuals, especially when the knowledge concerns various areas. Question Answering Communities offer an opportunity for sharing knowledge at a low cost, where communities users, many of whom are domain experts, can potentially provide high-quality solutions to a given problem. In this paper, we propose a framework for finding experts across multiple collaborative networks. We employ the recent techniques of tree-guided learning (via tensor decomposition), and matrix factorization to explore user expertise from past voted posts. Tensor decomposition enables to leverage the latent expertise of users, and the posts and related tags help identify the related areas. The final result is an expertise score for every user on every knowledge area. We experiment on Stack Exchange Networks, a set of question answering websites on different topics with a huge group of users and posts. Experiments show our proposed approach produces steady and premium outputs.
Space environment of Mercury at the time of the first MESSENGER flyby: Solar wind and interplanetary magnetic field modeling of upstream conditions: SPACE ENVIRONMENT OF MERCURY

[1] The first flyby of Mercury by the Mercury Surface, Space Environment, Geochemistry and Ranging (MESSENGER) spacecraft occurred on 14 January 2008. In order to provide contextual information about the solar wind (SW) properties and the interplanetary magnetic field near the planet, we have used an empirical modeling technique combined with a numerical physics-based SW model. The Wang-Sheeley-Arge (WSA) method uses solar photospheric magnetic field observations (from Earth-based instruments) in order to estimate inner heliospheric conditions out to 21.5 solar radii from the Sun. This information is then used as input to the global numerical magnetohydrodynamic model, ENLIL, which calculates SW velocity, density, temperature, and magnetic field strength and polarity throughout the inner heliosphere. The present paper shows WSA-ENLIL conditions computed for the several week period encompassing the first flyby. This information is used in conjunction with MESSENGER magnetometer data (and the only limited available MESSENGER SW plasma data) to help understand the Mercury flyby results. The in situ spacecraft data, in turn, can also be used iteratively to improve the model accuracy for inner heliospheric ‘‘space weather’’ purposes. Looking to the future, we discuss how with such modeling we can estimate relatively continuously the SW properties near Mercury and at the cruise location of MESSENGER now, for upcoming flybys, and toward the time of spacecraft orbit insertion in 2011.
Distance and similarity measures for hesitant fuzzy sets

In this paper, we propose a variety of distance measures for hesitant fuzzy sets, based on which the corresponding similarity measures can be obtained. We investigate the connections of the aforementioned distance measures and further develop a number of hesitant ordered weighted distance measures and hesitant ordered weighted similarity measures. They can alleviate the influence of unduly large (or small) deviations on the aggregation results by assigning them low (or high) weights. Several numerical examples are provided to illustrate these distance and similarity measures. 2011 Elsevier Inc. All rights reserved.
Formation of the Si/Ti interface

Abstract The formation of the Si/Ti interface during the deposition of silicon on titanium polycrystalline substrates has been studied at room temperature (RT) using X-ray photoelectron spectroscopy (XPS), angle-resolved XPS (ARXPS), ultraviolet photoelectron spectroscopy (UPS) and ion scattering spectroscopy (ISS). The experimental results are consistent with a two-stage mechanism for Si growth: a first stage characterized by the simultaneous formation of a uniform titanium silicide layer, that reaches a limiting thickness of ∼3 monolayer (ML), and pure silicon islands 1 ML thick that grow on top of this layer up to coalescence, followed by a second stage in which pure silicon islands, with an average thickness of 9 ML, grow on top of the uniform titanium silicide layer + pure silicon ML structure formed during the first stage. As a whole, pure silicon species grows according to a Stranski–Krastanov mechanism, where the first ML is formed during the first stage and the islands during the second stage. The comparison of Ti/Si and Si/Ti interfaces shows that the structure and composition of the interface do not depend substantially on the deposition sequence, suggesting that the bulk chemistry of the compound formed at the interface dominates over the surface kinetics and the bulk substrate chemistry in determining the composition and structure of the interface.
1 Rational Choice and Sociology

Rational-choice theorizing has a long tradition within sociology, but has always been controversial and contested. Yet it has influenced the theoretical vocabulary of the discipline at large and has made deep inroads into some important sociological areas such as social movements, social mobility, and religion. Most sociological rational-choice theories assume that actors act rationally in a broad sense, and focus on the aggregate outcomes that individual actors in interaction with one another are likely to bring about. This article reviews the most important contributions to the rational-choice tradition in sociology, and briefly discusses its historical past and its likely future.
Students' Perception to Psychological Counselling Services at Omdurman Islamic University in Khartoum State-Sudan

This study was conducted during (20122013) in Omdurman Islamic University, Khartoum State-Sudan. The study aimed to investigating the student perception toward psychological counseling services. Researchers used descriptive methods, by applied psychological counseling services questionnaire which designed by researchers. The community of this study consisted of (950) students. Sample was chosen randomly included (61) students included male (29) and female (32). The researchers used statistical package for social sciences program (SPSS). Also, the researcher used a number of statistical processes which are: T-test for one sample, T-test for independent sample, one way analysis of variance (ANOVA). Finally, the results are following: The level of psychological counseling services according to the view of Omdurman Islamic university student, is significant differences in view of students about psychological counseling services according to the gender, no significant differences in view of students about psychological counseling services according to the place of residence, no relationship between the view of students about psychological counseling services and age variable.
The psychology of being put on hold: An exploratory study of service quality

Customer satisfaction is one of the most important business objectives of the 1990s. One element identified as critical to satisfaction is quality. In the service sector, this objective is manifested in the form of service quality. Current research has concentrated on face-to-face interactions in their studies of service quality. However, many businesses conduct much of their business by phone. In addition, given the significant influence of time on consumers' daily lives, the telephone is becoming an increasingly important tool in their consumption habits. Telephone interactions represent a unique challenge to firms wishing to establish long-term relationships with their customers. This article explores the specific phenomenon of being placed on hold when calling a business and how this act affects the consumers' perceptions of service quality. © 1999 John Wiley & Sons, Inc.
The invisible addiction: Cell-phone activities and addiction among male and female college students

BACKGROUND AND AIMS
The primary objective of the present study was to investigate which cell-phone activities are associated with cell-phone addiction. No research to date has studied the full-range of cell-phone activities, and their relationship to cell-phone addiction, across male and female cell-phone users.


METHODS
College undergraduates (N = 164) participated in an online survey. Participants completed the questionnaire as part of their class requirements. The questionnaire took 10 and 15 minutes to complete and contained a measure of cell-phone addiction and questions that asked how much time participants spent daily on 24 cell-phone activities.


RESULTS
Findings revealed cell-phone activities that are associated significantly with cell-phone addiction (e.g., Instagram, Pinterest), as well as activities that one might logically assume would be associated with this form of addiction but are not (e.g., Internet use and Gaming). Cell-phone activities that drive cell-phone addiction (CPA) were found to vary considerably across male and female cell-phone users. Although a strong social component drove CPA for both males and females, the specific activities associated with CPA differed markedly.


CONCLUSIONS
CPA amongst the total sample is largely driven by a desire to connect socially. The activities found to be associated with CPA, however, differed across the sexes. As the functionality of cell-phones continues to expand, addiction to this seemingly indispensable piece of technology becomes an increasingly realistic possibility. Future research must identify the activities that push cell-phone use beyond its “tipping point” where it crosses the line from a helpful tool to one that undermines our personal well-being and that of others.
Terahertz Tomographic Imaging of Transdermal Drug Delivery

In vivo imaging methods to trace topical drugs within the skin are in high demand with recent advances in transdermal drug delivery technology. With imaging and chemical identification capabilities, terahertz (THz) spectroscopy can be a good modality for visualizing and quantifying transdermal drug delivery. In this study, we evaluated the feasibility of THz reflection tomographic imaging for visualizing the distribution and penetration of a topical agent, ketoprofen dissolved in DMSO, using ex vivo and in vivo mouse skins. THz reflection imaging of ex vivo and in vivo skins demonstrated greater contrast between the drug-applied sites and unapplied skin than that of visual images. The reflectance signal of drug-applied sites was determined by mixed THz response of skin tissue, diffused ketoprofen, and DMSO content. Interestingly, serial B-scan images revealed that a new dark layer appeared at the drug-applied sites 1 h after drug application, which might be related with permeated ketoprofen. This study demonstrates that THz imaging technique can be utilized for imaging the distribution of topically applied drugs.
Anytime/anyplace computing and the future of knowledge work

Considering the implications and consequences of the always-connected lifestyle.
Modelling and computing (Rn, Sn) policies for inventory systems with non-stationary stochastic demand

This paper addresses the single-item, non-stationary stochastic demand inventory control problem under the nonstationary (R,S) policy. In non-stationary (R,S) policies two sets of control parameters—the review intervals, which are not necessarily equal, and the order-up-to-levels for replenishment periods—are fixed at the beginning of the planning horizon to minimize the expected total cost. It is assumed that the total cost is comprised of fixed ordering costs and proportional direct item, inventory holding and shortage costs. With the common assumption that the actual demand per period is a normally distributed random variable about some forecast value, a certainty equivalent mixed integer linear programming model is developed for computing policy parameters. The model is obtained by means of a piecewise linear approximation to the non-linear terms in the cost function. Numerical examples are provided. 2005 Elsevier B.V. All rights reserved.
Kappa Opioid Receptors on Dopaminergic Neurons Are Necessary for Kappa-Mediated Place Aversion

Kappa-opioid receptor (KOR) agonists have dysphoric properties in humans and are aversive in rodents. This has been attributed to the activation of KORs within the mesolimbic dopamine (DA) system. However, the role of DA in KOR-mediated aversion and stress remains divisive as recent studies have suggested that activation of KORs on serotonergic neurons may be sufficient to mediate aversive behaviors. To address this question, we used conditional knock-out (KO) mice with KORs deleted on DA neurons (DATCre/wt/KORloxp/loxp, or DATCre-KOR KO). In agreement with previous findings, control mice (DATCre/wt/KORwt/wt or WT) showed conditioned place aversion (CPA) to the systemically administered KOR agonist U69,593. In contrast, DATCre-KOR KO mice did not exhibit CPA with this same agonist. In addition, in vivo microdialysis showed that systemic U69,593 decreased overflow of DA in the nucleus accumbens (NAc) in WT mice, but had no effect in DATCre-KOR KO mice. Intra- ventral tegmental area (VTA) delivery of KORs using an adeno-associated viral gene construct, resulted in phenotypic rescue of the KOR-mediated NAc DA response and aversive behavior in DATCre-KOR KO animals. These results provide evidence that KORs on VTA DA neurons are necessary to mediate KOR-mediated aversive behavior. Therefore, our data, along with recent findings, suggest that the neuronal mechanisms of KOR-mediated aversive behavior may include both dopaminergic and serotonergic components.
cial Effects of Probiotics , Prebiotics , Synbiotics , and Psychobiotics in In fl ammatory Bowel Disease

Inflammatory bowel disease (IBD) is a group of diseases characterized by inflammation of the small and large intestine and primarily includes ulcerative colitis and Crohn’s disease. Although the etiology of IBD is not fully understood, it is believed to result from the interaction of genetic, immunological, and environmental factors, including gut microbiota. Recent studies have shown a correlation between changes in the composition of the intestinal microbiota and IBD. Moreover, it has been suggested that probiotics and prebiotics influence the balance of beneficial and detrimental bacterial species, and thereby determine homeostasis versus inflammatory conditions. In this review, we focus on recent advances in the understanding of the role of prebiotics, probiotics, and synbiotics in functions of the gastrointestinal tract and the induction and maintenance of IBD remission. We also discuss the role of psychobiotics, which constitute a novel class of psychotropic agents that affect the central nervous system by influencing gut microbiota. (Inflamm Bowel Dis 2015;21:1674–1682)
Replay-based strategy prediction and build order adaptation for StarCraft AI bots

StarCraft is a real-time strategy (RTS) game and the choice of strategy has big impact on the final results of the game. For human players, the most important thing in the game is to select the strategy in the early stage of the game. Also, it is important to recognize the opponent's strategy as quickly as possible. Because of the “fog-of-war” in the game, the player should send a scouting unit to opponent's hidden territory and the player predicts the types of strategy from the partially observed information. Usually, expert players are familiar with the relationships between two build orders and they can change the current build order if his choice is not strong to the opponent's strategy. However, players in AI competitions show quite different behaviors compared to the human leagues. For example, they usually have a pre-selected build order and rarely change their order during the game. In fact, the computer players have little interest in recognizing opponent's strategy and scouting units are used in a limited manner. The reason is that the implementation of scouting behavior and the change of build order from the scouting vision is not a trivial problem. In this paper, we propose to use replays to predict the strategy of players and make decision on the change of build orders. Experimental results on the public replay files show that the proposed method predicts opponent's strategy accurately and increases the chance of winning in the game.
Cultural Relativism and the Savage: The Alleged Inconsistency of William Graham Sumner

Judged by his political and economic writings, the 19th-century thinker William Graham Sumner (1840-1910) is a conservative, a Social Darwinist, and something of a libertarian, who looked down on members of less developed cultures. However, as a sociologist, he is remembered for formulating the distinction between ethnocentrism and cultural relativism, and is considered an early contributor to multiculturalism theory. Is it simply the case that Sumner was inconsistent, or have his works perhaps been misunderstood? Copyright 2004 American Journal of Economics and Sociology, Inc..
Financial institutions and social transformations : international studies of a sector

Acknowledgements - Notes on the Contributors - An Industry in Transition: Regulation, Restructuring and Renewal D.Knights - The Dialectic of the Value Form: The Social Evolution of Capital Markets in the US T.Tinker - Suburban Subjects: Financial Services and the New Rights C.Grey - The Acrobat of Desire: Consumer Credit and its Linkages to Modern Consumerism M.Shaoul - Bringing the Consumer in: Sales Networks in Retail Banking in New Zealand T.Austrin - Financial Services in Transition: An Examination of Market and Regulatory Forces in Denmark and the UK J.Sundbo - Stability or Transformation of Employment Relations in German Banking M.Muller - Marketing the Soul: From the Ideology of Consumption to Consumer Subjectivity D.Knights and A.Sturdy - The Japanese Main Bank Relationship: Governance or Competitive Strategy? M.J.Scher - Index