LLukas22/scidocs huggingface dataset:
Antibiotic Resistance of Pseudomonas aeruginosa in Pneumonia at a Single University Hospital Center in Germany over a 10-Year Period

BACKGROUND
Pseudomonas aeruginosa is a common cause of community-acquired and nosocomial-acquired pneumonia. The development of resistance of P. aeruginosa to antibiotics is increasing globally due to the overuse of antibiotics. This article examines, retrospectively, the antibiotic resistance in patients with community-acquired versus nosocomial-acquired pneumonia caused by P. aeruginosa or multidrug-resistant (MDR) P. aeruginosa.


METHODS
Data from patients with community-acquired and nosocomial-acquired pneumonia caused by P. aeruginosa and MDR P. aeruginosa were collected from the hospital charts at the HELIOS Clinic, Witten/Herdecke University, Wuppertal, Germany, between January 2004 and August 2014. An antibiogram was created from all study patients with community-acquired and nosocomial-acquired pneumonia caused by P. aeruginosa or MDR P. aeruginosa.


RESULTS
A total of 168 patients with mean age 68.1 ± 12.8 (113 [67.3% males and 55 [32.7%] females) were identified; 91 (54.2%) had community-acquired and 77 (45.8%) had nosocomial-acquired pneumonia caused by P. aeruginosa. Patients with community-acquired versus nosocomial-acquired pneumonia had a mean age of 66.4 ± 13.8 vs. 70.1 ± 11.4 years [59 vs. 54 (64.8% vs. 70.1%) males and 32 vs. 23 (35.2% vs. 29.9%) females]. They included 41 (24.4%) patients with pneumonia due to MDR P. aeruginosa: 27 (65.9%) community-acquired and 14 (34.1%) nosocomial-acquired cases. P. aeruginosa and MDR P. aeruginosa showed a very high resistance to fosfomycin (community-acquired vs. nosocomial-acquired) (81.0% vs. 84.2%; 0 vs. 85.7%). A similar resistance pattern was seen with ciprofloxacin (35.2% vs. 24.0%; 70.4% vs. 61.5%), levofloxacin (34.6% vs. 24.5%; 66.7% vs. 64.3%), ceftazidime (15.9% vs. 30.9; 33.3% vs. 61.5%), piperacillin (24.2% vs. 29.9%; 44.4% vs. 57.1%), imipenem (28.6% vs. 27.3%; 55.6% vs. 50.0%), piperacillin and tazobactam (23.1% vs. 28.6%; 44.4% vs. 50.0%), tobramycin (28.0% vs. 17.2%; 52.0% vs. 27.3%), gentamicin (26.4% vs. 18.2%; 44.4% vs. 21.4%), and meropenem (20.2% vs. 20.3%; 42.3% vs. 50.0%). An elevated resistance of P. aeruginosa and MDR P. aeruginosa was found for cefepime (11.1% vs. 23.3%; 25.9% vs. 50.0%), and amikacin (10.2% vs. 9.1%; 27.3% vs. 9.1%). Neither pathogen was resistant to colistin (P = 0.574).


CONCLUSION
While P. aeruginosa and MDR P. aeruginosa were resistant to a variety of commonly used antibiotics, they were not resistant to colistin in the few isolates recovered from patients with pneumonia.
Do parental psychopathology and unfavorable family environment predict the persistence of social phobia?

Parental psychopathology and unfavorable family environment are established risk factors for onset of offspring social phobia (SP), but their associations with the further course, e.g., persistence of the disorder, remain understudied. A community cohort of 1395 adolescents and their parents was followed-up over almost 10 years using the DIA-X/M-CIDI. Parental diagnostic interviews were supplemented by family history data. Parental rearing was retrospectively assessed by the Questionnaire of Recalled Parental Rearing Behavior in offspring, and family functioning by the Family Assessment Device in parents. Persistence measures (proportion of years affected since onset) were derived from diagnostic interviews, using age of onset, age of recency, and course information. Lack of emotional warmth and dysfunctional family functioning characteristics were associated with higher SP persistence, particularly in interaction with parental psychopathology. Predictors for SP persistence differ from those predicting SP onset. Unfavorable family environment alone and in interaction with parental disorders predict higher SP persistence.
A LYAPUNOV ISS SMALL-GAIN THEOREM FOR STRONGLY CONNECTED NETWORKS

We consider strongly connected networks of input-to-state stable (ISS) systems. Provided a small gain condition holds it is shown how to construct an ISS Lyapunov function using ISS Lyapunov functions of the subsystems. The construction relies on two steps: The construction of a strictly increasing path in a region defined on the positive orthant in R by the gain matrix and the combination of the given ISS Lyapunov functions of the subsystems to a ISS Lyapunov function for the composite system. Novelties are the explicit path construction and that all the involved Lyapunov functions are nonsmooth, i.e., they are only required to be locally Lipschitz continuous. The existence of a nonsmooth ISS Lyapunov function is qualitatively equivalent to ISS.
Human exploration of Mars, Design Reference Architecture 5.0

This paper provides a summary of the 2007 Mars Design Reference Architecture 5.0 (DRA 5.0) [1], which is the latest in a series of NASA Mars reference missions. It provides a vision of one potential approach to human Mars exploration, including how Constellation systems could be used. The strategy and example implementation concepts that are described here should not be viewed as constituting a formal plan for the human exploration of Mars, but rather provide a common framework for future planning of systems concepts, technology development, and operational testing as well as potential Mars robotic missions, research that is conducted on the International Space Station, and future potential lunar exploration missions. This summary of the Mars DRA 5.0 provides an overview of the overall mission approach, surface strategy and exploration goals, as well as the key systems and challenges for the first three concepts for human missions to Mars.1,2
The effect of dietary glutamate on fibromyalgia and irritable bowel symptoms.

OBJECTIVES
To examine the effects of a challenge with monosodium glutamate (MSG) as compared to placebo on the symptoms of fibromyalgia (FM), in participants who initially experienced >30% remission of symptoms on an excitotoxin elimination diet.


METHODS
Fifty-seven FM patients who also had irritable bowel syndrome (IBS) were placed on a 4-week diet that excluded dietary additive excitotoxins including MSG and aspartame. Thirty-seven people completed the diet and 84% of those reported that >30% of their symptoms resolved, thus making them eligible to proceed to challenges. Subjects who improved on the diet were then randomised to a 2-week double-blind placebo-controlled crossover challenge with MSG or placebo for 3 consecutive days each week. The primary outcome measure was total symptom score. Secondary outcome measures included visual analogue pain scales (VAS for FM and IBS), an IBS Quality of Life Questionnaire (IBS QOL) and the Fibromyalgia Impact Questionnaire-Revised (FIQR). Repeated measures ANOVA was used to analyse crossover challenge results.


RESULTS
The MSG challenge, as compared to placebo, resulted in a significant return of symptoms (total symptom score, p<0.02); a worsening of fibromyalgia severity as determined by the FIQR (p<0.03); decreased quality of life in regards to IBS symptoms (IBS QOL, p<0.05); and a non-significant trend toward worsening FM pain based on visual analogue scale (VAS, p<0.07).


CONCLUSIONS
These findings suggest that dietary glutamate may be contributing to FM symptoms in some patients. Future research on the role of dietary excitotoxins in FM is warranted.
Metacognition, achievement goals, study strategies and academic achievement: pathways to achievement

The purpose of this research was to develop and test a model of effective selfregulated learning. Based on effort expenditure we discerned effective self-regulators and less effective self-regulators. The model comprised achievement goals (mastery, performance-approach and -avoidance goals), metacognition (metacognitive knowledge, regulation and experience), study strategies (metacognitive, deep cognitive, surface cognitive and resource management strategies) and academic achievement. The relationships in the model were tested with controlling for intellectual ability, gender and age. The results showed that effective self-regulated learning involved two pathways: a metacognitive and a strategy pathway. The first pathway involved a positive relationship of mastery goals and a negative relationship of performance-avoidance goals with metacognition. Metacognition positively affected the use of the four study strategies. The strategy pathway involved positive effects of mastery and performance-approach goals on the use of metacognitive and deep cognitive strategies. Further, performance-approach goals positively affected the use of surface cognitive and resource management strategies. The use of metacognitive and resource management strategies had a positive and the use of surface cognitive strategies had a negative effect on exam scores.
Capability Maturity Model for Software

The iedas and findigs in tiis document shouid not be construed as an official DoD position. It is published in the interest of scientific and technical information exchange. 'L-z , ay it-sademarks in this document is not intended in any way to infringe on the rights of the trademark holder.
Design and control of a lightweight magnetic climbing robot for vessel inspection

The inspection of marine vessels is currently performed manually. Inspectors use sensors (e.g. cameras, devices for non-destructive testing) to detect damaged areas, cracks, and corrosion in large cargo holds, tanks, and other parts of a ship. Due to the size and complex geometry of most ships, ship inspection is time-consuming and expensive. The EU-funded project MINOAS develops concepts for a Marine Inspection Robotic Assistant System to improve and to automate ship inspections. As one example of a physical system implementation, we introduce our magnetic wall-climbing robot. This remotely operated lightweight system is able to climb a vessels steel frame and is able to deliver visual inspection data on-line. For any type of surveying process, the raw and meta data are mandatory in order to compare inspection data over time. In this paper, we describe our approach of how the magnetic climbing robot is localized and controlled. Additionally, we describe the design of the robot as well as the localization device which is able to provide a real-time 3D pose of the inspection robot.
A Novel Parallel Sorting Algorithm for Contemporary Architectures

Modern scientic codes often combine numerical methods with combinatorial methods. Sorting, a widely studied problem in computer science, is an important primitive for combinatorial scientic computing. Increasingly, scientic codes target parallel computers. Scientic programming environments such as Matlab, Python, R, and Star-P provide sorting as a built-in function. We present a parallel sorting algorithm that is close to optimal in computation and communication, along with scaling results for shared and distributed memory architectures. One of the core motivations for developing this code was the lack of a quality scalable parallel sorting library. Our sorting library is available as open source and is written to be compatible with the C++ Standard Template Library. The code is available for download at http://gauss.cs.ucsb.edu/code/index.shtml
From popularity prediction to ranking online news

News articles are an engaging type of online content that captures the attention of a significant amount of Internet users. They are particularly enjoyed by mobile users and massively spread through online social platforms. As a result, there is an increased interest in discovering the articles that will become popular among users. This objective falls under the broad scope of content popularity prediction and has direct implications in the development of new services for online advertisement and content distribution. In this paper, we address the problem of predicting the popularity of news articles based on user comments. We formulate the prediction task as a ranking problem, where the goal is not to infer the precise attention that a content will receive but to accurately rank articles based on their predicted popularity. Using data obtained from two important news sites in France and Netherlands, we analyze the ranking effectiveness of two prediction models. Our results indicate that popularity prediction methods are adequate solutions for this ranking task and could be considered as a valuable alternative for automatic online news ranking.
Feminizing Genital Gender-Confirmation Surgery.

INTRODUCTION
For many patients with gender dysphoria, gender-confirmation surgery (GCS) helps align their physical characteristics with their gender identity and is a fundamental element of comprehensive treatment. This article is the 2nd in a 3-part series about the treatment of gender dysphoria. Non-operative management was covered in part 1. This section begins broadly by reviewing surgical eligibility criteria, benefits of GCS, and factors associated with regret for transgender men and women. Then, the scope narrows to focus on aspects of feminizing genital GCS, including a discussion of vaginoplasty techniques, complications, and sexual function outcomes. Part 3 features operative considerations for masculinizing genital GCS.


AIM
To summarize the World Professional Association for Transgender Health's (WPATH) surgical eligibility criteria and describe how patients with gender dysphoria benefit from GCS, provide an overview of genital and non-genital feminizing gender-confirmation procedures, and review vaginoplasty techniques, preoperative considerations, complications, and outcomes.


METHODS
A review of relevant literature through April 2017 was performed using PubMed.


MAIN OUTCOME MEASURES
Review of literature related to surgical eligibility criteria for GCS, benefits of GCS, and surgical considerations for feminizing genitoplasty.


RESULTS
Most transgender men and women who satisfy WPATH eligibility criteria experience improved quality of life, overall happiness, and sexual function after GCS; regret is rare. Penile inversion vaginoplasty is the preferred technique for feminizing genital GCS according to most surgeons, including the authors whose surgical technique is described. Intestinal vaginoplasty is reserved for certain scenarios. After vaginoplasty most patients report overall high satisfaction with their sexual function even when complications occur, because most are minor and easily treatable.


CONCLUSION
GCS alleviates gender dysphoria for appropriately selected transgender men and women. Preoperative, intraoperative, and postoperative considerations of feminizing genital gender-confirmation procedures were reviewed. Hadj-Moussa M, Ohl DA, Kuzon WM. Feminizing Genital Gender-Confirmation Surgery. Sex Med Rev 2018;6:457-468.
The velocity structure of the Cariaco sedimentary basin, northeastern Venezuela, from refraction seismic data and possible relationship to earthquake hazard

Abstract The main damage from the July 9, 1997, Cariaco earthquake (Ms=6.8) was concentrated in the town of Cariaco and surrounding villages, which are located in the western part of the Cariaco sedimentary basin, close to the Gulf of Cariaco. Casanay, located at the eastern end of the sedimentary basin, suffered considerably less damage. The El Pilar fault, a right-lateral strike-slip fault that generated the earthquake, runs parallel to the southern border of the valley and crosses both towns. The determination of the velocity structure of the basin is the main objective of this study. Seismic refraction data were recorded along three lines, one of them along-strike and two perpendicular to the valley axis in the northern and southern bedrocks. Beneath Cariaco, approximately 1 km thick Quaternary sediments with seismic velocities of 1.9–2.1 km/s and bedrock velocities of more than 4 km/s were observed. The thickness of the Quaternary sediments varies within the basin, and Pleistocene sediments outcrop beneath Casanay. The increased thickness of the unconsolidated, water-saturated Quaternary sediments, together with the difference in the quality of buildings prior to the earthquake, probably is responsible for the damage pattern of the Cariaco earthquake.
The Relationship of Personality Characteristics, Life Stress, and Coping Resources to Athletic Injury

In 1988, Andersen and Williams proposed a model to explain the stressinjury relationship. The present study tested portions of this framework by investigating frequency and severity of injury occurrence in track and field athletes from four NCAA Division I and I1 universities. Personality characteristics (locus of control and sport competition trait anxiety), history of stressors (life stress, daily hassles, and past injury), and moderating variables (coping resources and social support) were assessed before the season began. Discriminant analyses indicated that four variables (coping resources, negative life stress, social support, and competitive anxiety) differentiated the severity groups. For injury frequency, coping resources and positive life stress differentiated the groups.
Exploring the Geographical Relations Between Social Media and Flood Phenomena to Improve Situational Awareness - A Study About the River Elbe Flood in June 2013

Recent research has shown that social media platforms like twitter can provide relevant information to improve situation awareness during emergencies. Previous work is mostly concentrated on the classification and analysis of tweets utilizing crowdsourcing or machine learning techniques. However, managing the high volume and velocity of social media messages still remains challenging. In order to enhance information extraction from social media, this chapter presents a new approach that relies upon the geographical relations between twitter data and flood phenomena. Our approach uses specific geographical features like hydrological data and digital elevation models to prioritize crisis-relevant twitter messages. We apply this approach to examine the River Elbe Flood in Germany in June 2013. The results show that our approach based on geographical relations can enhance information extraction fromvolunteered geographic information, thus being valuable for both crisis response and preventive flood monitoring.
Expression of claudin-2 in the multistage process of gastric carcinogenesis.

OBJECTIVE
Claudin-2 is an important component of the tight junction (TJ) of epithelial cells, and its protein expression between many tumours is significantly different. It is unclear if Claudin-2 overexpression is a trigger or a consequence during carcinogenesis. The multistage tissues of gastric carcinogenesis provides us a valuable model for determining tumourigenicity.


METHODS
This paper investigated, for the first time, claudin-2 expression in the pathological paraffin tissues of sinus ventriculi from gastroscopic biopsy. To determine claudin-2 expression in gastric carcinogenesis by immunochemical ABC technique.


RESULTS
Altogether, 108 chronic superficial gastritis, 55 chronic atrophic gastritis, 109 intestinal-type metaplasia, 93 dysplasia and 52 gastric intestinal-type adenocarcinoma samples were analyzed. Results indicated that the percentage of claudin-2-positive cases was 0% for chronic superficial gastritis (0/108), 0% for chronic atrophic gastritis (0/55), 0% for intestinal-type metaplasia (0/109), 35.87% for dysplasia (33/92), and 73.47% for gastric intestinal-type adenocarcinoma (36/49) respectively, primarily in the cell membrane, and gradually increased in the multistage process of gastric carcinogenesis (P<0.001).


CONCLUSIONS
This suggests that claudin-2 protein overexpression may be closely correlated to gastric carcinogenesis.
Surveillance for dental caries, dental sealants, tooth retention, edentulism, and enamel fluorosis--United States, 1988-1994 and 1999-2002.

PROBLEM/CONDITION
Dental caries is a common chronic disease that causes pain and disability across all age groups. If left untreated, dental caries can lead to pain and infection, tooth loss, and edentulism (total tooth loss). Dental sealants are effective in preventing dental caries in the occlusal (chewing) and other pitted and fissured surfaces of the teeth. Enamel fluorosis is a hypomineralization of enamel related to fluoride exposure during tooth formation (first 6 years for most permanent teeth). Exposure to fluoride throughout life is effective in preventing dental caries. This is the first CDC Surveillance Summary that addresses these conditions and practices.


REPORTING PERIOD
1988-1994 and 1999-2002.


SYSTEM DESCRIPTION
The National Health and Nutrition Examination Survey (NHANES) is an ongoing survey of representative samples of the civilian, noninstitutionalized U.S. population aged >/=2 months in NHANES 1988-1994 and all ages during 1999-2002. The dental component gathered information on persons aged >/=2 years.


RESULTS
During 1999-2002, among children aged 2-11 years, 41% had dental caries in their primary teeth. Forty-two percent of children and adolescents aged 6-19 years and approximately 90% of adults had dental caries in their permanent teeth. Among children aged 6-19 years, 32% had received dental sealants. Adults aged >/=20 years retained a mean of 24 of 28 natural teeth and 8% were edentulous. Among persons aged 6-39 years, 23% had very mild or greater enamel fluorosis. Disparities were noticed across all age groups, among racial/ethnic groups, persons with lower education and income, and by smoking status. From 1988-1994 to 1999-2002, four trends were observed: 1) no change in the prevalence of dental caries in primary teeth among children aged 2-11 years, 2) a reduction in prevalence of caries in permanent teeth of up to 10 percentage points among persons aged 6-19 years and up to six percentage points among dentate adults aged >/=20 years, 3) an increase of 13 percentage points in dental sealants among persons aged 6-19 years, and 4) a six percentage point reduction in total tooth loss (edentulism) among persons aged >/=60 years.


INTERPRETATION
The findings of this report indicate that the dental caries status of permanent teeth has improved since the 1988-1994 survey. Despite the decrease in caries prevalence and severity in the permanent dentition and the increase in the proportion of children and adolescents who benefit from dental sealants, disparities remain.


PUBLIC HEALTH ACTION
These data provide information for public health professionals in designing interventions to improve oral health and to reduce disparities in oral health, for researchers in assessing factors associated with disparities and dental caries in primary teeth, and in designing timely surveillance tools to monitor total fluoride exposure.