LLukas22/scidocs huggingface dataset:
Pharmacokinetics of abacavir and its anabolite carbovir triphosphate without and with darunavir/ritonavir or raltegravir in HIV-infected subjects.

BACKGROUND
Here, we aimed to investigate the pharmacokinetics of abacavir and carbovir triphosphate (CBV-TP) with darunavir/ritonavir 900/100 mg once daily or raltegravir 400 mg twice daily.


METHODS
HIV-infected subjects on abacavir (600 mg once daily) underwent steady-state pharmacokinetic assessments without and with darunavir/ritonavir or raltegravir. Within-subject changes in plasma and intracellular pharmacokinetic parameters were evaluated by geometric mean ratios (GMRs) and 90% CIs.


RESULTS
A total of 19 patients completed the study. With darunavir/ritonavir (versus abacavir alone), abacavir GMRs (90% CI) were 0.73 (0.66, 0.80), 0.62 (0.50, 0.77) and 0.78 (0.69, 0.87) for area under the curve (AUC), trough concentration (C(trough)) and maximum concentration (C(max)), respectively. With raltegravir, they were 1.03 (0.97, 1.10), 0.83 (0.62, 1.11) and 1.06 (0.95, 1.18), respectively. Intracellular CBV-TP GMRs (90% CI) were 0.88 (0.72, 1.07), 0.68 (0.48, 0.95) and 0.98 (0.79, 1.23) for AUC, C(trough) and C(max), respectively, with darunavir/ritonavir, and 0.96 (0.76, 1.20), 0.57 (0.33, 1.00) and 1.07 (0.85, 1.35), respectively, with raltegravir.


CONCLUSIONS
There was a 27% decrease in abacavir plasma exposure with darunavir/ritonavir and no changes with raltegravir. CBV-TP C(trough) was significantly decreased with darunavir/ritonavir (32%) and showed a high inter-individual variability with raltegravir.
Mobility Prediction in Wireless Ad Hoc Networks using Neural Networks

Mobility prediction allows estimating the stability of paths in a mobile wireless Ad Hoc networks. Identifying stable paths helps to improve routing by reducing the overhead and the number of connection interruptions. In this paper, we introduce a neural network based method for mobility prediction in Ad Hoc networks. This method consists of a multi-layer and recurrent neural network using back propagation through time algorithm for training.
Emotionally Expressive Avatars for Chatting, Learning and Therapeutic Intervention

We present our work on emotionally expressive avatars, animated virtual characters that can express emotions via facial expressions. Because these avatars are highly distinctive and easily recognizable, they may be used in a range of applications. In the first part of the paper we present their use in computer mediated communication where two or more people meet in virtual space, each represented by an avatar. Study results suggest that social interaction behavior from the real-world is readily transferred to the virtual world. Empathy is identified as a key component for creating a more enjoyable experience and greater harmony between users. In the second part of the paper we discuss the use of avatars as an assistive, educational and therapeutic technology for people with autism. Based on the results of a preliminary study, we provide pointers regarding how people with autism may overcome some of the limitations that characterize their condition.
Government by experiment? Global cities and the governing of climate change

In this paper, we argue for an approach which goes beyond an institutional reading of urban climate governance to engage with the ways in which government is accomplished through social and technical practices. Central to the exercise of government in this manner, we argue, are ‘climate change experiments’ – purposive interventions in urban socio-technical systems designed to respond to the imperatives of mitigating and adapting to climate change in the city. Drawing on three different concepts – of governance experiments, sociotechnical experiments, and strategic experiments – we first develop a framework for understanding the nature and dynamics of urban climate change experiments. We use this conceptual analysis to frame a scoping study of the global dimensions of urban climate change experimentation in a database of 627 urban climate change experiments in 100 global cities. The analysis charts when and where these experiments occur, the relationship between the social and technical aspects of experimentation and the governance of urban climate change experimentation, including the actors involved in their governing and the extent to which new political spaces for experimentation are emerging in the contemporary city. We find that experiments serve to create new forms of political space within the city, as public and private authority blur, and are primarily enacted through forms of technical intervention in infrastructure networks, drawing attention to the importance of such sites in urban climate politics. These findings point to an emerging research agenda on urban climate change experiments which needs to engage with the diversity of experimentation in
Effective educators are culturally competent communicators

Effective formal education or schooling is not simply a matter of teaching and learning curriculum content. It is also about values, assumptions, feelings, perceptions and relationships. No education can take place without interpersonal communication. Effective teaching can thus be quali ed in terms of relating effectively in the classroom. Effective education thus also presupposes effective communication skills. Communication as the means and indeed the medium of education is therefore crucial to school success in culturally diverse education. Teachers should therefore be sensitive to the potentially problematic outcomes of intercultural communication in the culturally diverse class. Communication may be a useful source of intercultural knowledge and mutual enrichment between culturally diverse students if managed proactively by the teacher. Otherwise, it could be a source of frustration, misapprehensions, intercultural con ict and ultimately school failure. Effective and successful communication is dif cult to realise even in the most favourable circumstances. Intercultural factors, therefore, create the potential for numerous communication problems and intercultural con ict. Communication, both verbal as well as non-verbal, is critically important in cross-cultural competence. As language and culture are inextricably bound, cross-cultural communication is complex and potentially problematic. In this paper, it is argued that effective educators are effective communicators and thus culturally competent in cross-cultural encounters.
Patent claim decomposition for improved information extraction

In several application domains research in natural language processing and information extraction has spawned valuable tools that support humans in structuring, aggregating and managing large amounts of information available as text. Patent claims, although subject to a number of rigid constraints and therefore forced into foreseeable structures, are written in a language even good parsing algorithms tend to fail miserably at. This is primarily caused by long and complex sentences that are a concatenation of a multitude of descriptive elements. We present an approach to split patent claims into several parts in order to improve parsing performance for further automatic processing.
TEACHERS SENSE OF SELF-EFFICACY, ENGLISH PROFICIENCY, AND INSTRUCTIONAL STRATEGIES: A STUDY OF NONNATIVE EFL TEACHERS IN IRAN

This study examined the efficacy beliefs of nonnative English speaking (NNES) Iranian EFL teachers. EFL teachers' perceptions of their teaching efficacy in terms of personal capabilities to teach English as a Foreign Language (EFL) and their perceived English language proficiency level were examined. A modified version of the Teacher Sense of Efficacy Scale (Tschannen-Moran & Woolfolk Hoy, 2001) was used to assess efficacy for management, engagement, and instructional strategies. Based on Chacón's (2005) study, two other subscales (self-reported proficiency and pedagogical strategies) were also used. The results showed that the teachers' perceived efficacy was positively correlated with self-reported English proficiency. The findings also revealed that the more efficacious the teachers felt, the more inclined they were to use communicative-based strategies. The study has implications for the preparation of NNES teachers and the support they need to develop their language proficiency, which in turn is related to their perceived self-efficacy.
Widespread reductions in gray matter volume in depression☆

Abnormalities in functional limbic-anterior cingulate-prefrontal circuits associated with emotional reactivity, evaluation and regulation have been implicated in the pathophysiology of major depressive disorder (MDD). However, existing knowledge about structural alterations in depression is equivocal and based on cohorts of limited sample size. This study used voxel-based morphometry (VBM) and surface-based cortical thickness to investigate the structure of these circuits in a large and well-characterized patient cohort with MDD. Non-geriatric MDD outpatients (n = 102) and age- and gender-matched healthy control participants (n = 34) provided T1-weighted magnetic resonance imaging data during their baseline visit as part of the International Study to Predict Optimized Treatment for Depression. Whole-brain VBM volumetric and surface-based cortical thickness assessments were performed voxel-wise and compared (at p < 0.05 corrected for multiple comparisons) between the MDD and control groups. MDD participants had reduced gray matter volume in the anterior cingulate cortex, regions of the prefrontal circuits, including dorsolateral and dorsomedial prefrontal cortices, and lateral and medial orbitofrontal cortices, but not in limbic regions. Additional reductions were observed cortically in the posterior temporal and parieto-occipital cortices and, subcortically in the basal ganglia and cerebellum. Focal cortical thinning in the medial orbitofrontal cortex was also observed for the MDD group. These alterations in volume and cortical thickness were not associated with severity of depressive symptoms. The findings demonstrate that widespread gray matter structural abnormalities are present in a well-powered study of patients with depression. The patterns of gray matter loss correspond to the same brain functional network regions that were previously established to be abnormal in MDD, which may support an underlying structural abnormality for these circuits.
Addition of clopidogrel to aspirin in 45,852 patients with acute myocardial infarction: randomised placebo-controlled trial.

BACKGROUND
Despite improvements in the emergency treatment of myocardial infarction (MI), early mortality and morbidity remain high. The antiplatelet agent clopidogrel adds to the benefit of aspirin in acute coronary syndromes without ST-segment elevation, but its effects in patients with ST-elevation MI were unclear.


METHODS
45,852 patients admitted to 1250 hospitals within 24 h of suspected acute MI onset were randomly allocated clopidogrel 75 mg daily (n=22,961) or matching placebo (n=22,891) in addition to aspirin 162 mg daily. 93% had ST-segment elevation or bundle branch block, and 7% had ST-segment depression. Treatment was to continue until discharge or up to 4 weeks in hospital (mean 15 days in survivors) and 93% of patients completed it. The two prespecified co-primary outcomes were: (1) the composite of death, reinfarction, or stroke; and (2) death from any cause during the scheduled treatment period. Comparisons were by intention to treat, and used the log-rank method. This trial is registered with ClinicalTrials.gov, number NCT00222573.


FINDINGS
Allocation to clopidogrel produced a highly significant 9% (95% CI 3-14) proportional reduction in death, reinfarction, or stroke (2121 [9.2%] clopidogrel vs 2310 [10.1%] placebo; p=0.002), corresponding to nine (SE 3) fewer events per 1000 patients treated for about 2 weeks. There was also a significant 7% (1-13) proportional reduction in any death (1726 [7.5%] vs 1845 [8.1%]; p=0.03). These effects on death, reinfarction, and stroke seemed consistent across a wide range of patients and independent of other treatments being used. Considering all fatal, transfused, or cerebral bleeds together, no significant excess risk was noted with clopidogrel, either overall (134 [0.58%] vs 125 [0.55%]; p=0.59), or in patients aged older than 70 years or in those given fibrinolytic therapy.


INTERPRETATION
In a wide range of patients with acute MI, adding clopidogrel 75 mg daily to aspirin and other standard treatments (such as fibrinolytic therapy) safely reduces mortality and major vascular events in hospital, and should be considered routinely.
A cohort study of incident myopia in Singaporean children.

PURPOSE
To determine the risk factors of incident myopia in a school-based cohort study in Singaporean children.


METHODS
A 3-year prospective cohort study was conducted in Singaporean school children aged 7 to 9 years in three schools at entry. Chinese children without myopia at baseline (n = 994) were included in the analysis. The main outcome was incident myopia, defined as spherical equivalent (SE) at least -0.75 D based on cycloplegic autorefraction. Other definitions of incident myopia, at least -0.5 D and at least -1.0 D, were also assessed.


RESULTS
After controlling for school, age, gender, income, reading in books per week and intelligence quotient (IQ) test scores, we found the relative risk (RR) of incident myopia defined as -0.75 D to be 1.55 (95% confidence interval [CI] 1.18-2.04) for two versus no myopic parents. The multivariate RR of myopia for IQ in the third versus first tertile was 1.50 (95% CI, 1.19-1.89). However, the RR of incident myopia was 1.01 (95% CI, 0.97-1.05) for every unit increase in books read per week. Similar results were obtained with definitions of -0.5 and -1.0 D for incident myopia.


CONCLUSIONS
These data provide new prospective evidence of essential links between parental myopia, IQ scores and subsequent myopia development. However, reading in books per week was not associated with incident myopia.
Effect of processing on the crystalline orientation, morphology, and mechanical properties of polypropylene cast films and microporous membrane formation

Cast films of a high molecular weight linear polypropylene (L-PP) were prepared by extrusion followed by stretching using a chill roll. An air knife was employed to supply air to the film surface right at the exit of the die. The effects of air cooling conditions, chill roll temperature, and draw ratio on the crystalline orientation, morphology, mechanical and tear properties of the PP cast films were investigated. The crystallinity and crystal size distribution of the films were studied using differential scanning calorimetry (DSC). It was found that air blowing on the films contributed significantly to the uniformity of the lamellar structure. The orientation of crystalline and amorphous phases was measured using wide angle X-ray diffraction (WAXD) and Fourier transform infrared (FTIR). The amount of lamellae formation and long period spacing were obtained via small angle X-ray scattering (SAXS). The results showed that air cooling and the cast roll temperature have a crucial role on the orientation and amount of lamellae formation of the cast films, which was also confirmed from scanning electron microscopy (SEM) images of the films. Tensile properties and tear resistance of the cast films in machine and transverse directions (MD and TD, respectively) were evaluated. Significant increases of the Young modulus, yield stress, tensile strength, and tensile toughness along MD and drastic decreases of elongation at break along TD were observed for films subjected to air blowing. Morphological pictograms are proposed to represent the molecular structure of the films obtained without and upon applying air cooling for different chill roll temperatures. Finally, microporous membranes were prepared from annealed and stretched films to illustrate the effect of the PP cast film microstructure on the morphology and permeability of membranes. The observations of SEM surface images and water vapor transmission rate of the membranes showed higher pore density, uniform pore size, and superior permeability for the ones obtained from the precursor films prepared under controlled air cooling. 2009 Published by Elsevier Ltd.
NHE 1 Regulates the Stratum Corneum Permeability Barrier Homeostasis MICROENVIRONMENT ACIDIFICATION ASSESSED WITH FLUORESCENCE LIFETIME IMAGING *

From the ‡Dermatology Service, Veterans Affairs Medical Center and Department of Dermatology, University of California, San Francisco, California 94121, the ¶Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, University of Cincinnati, Cincinnati, Ohio 45267, and the **Laboratory for Fluorescence Dynamics, Department of Physics, University of Illinois, Urbana-Champaign, Illinois 61801
The Cape Dutch Reformed Church Mission in Malawi: A Preliminary Historical Examination Of Its Educational Philosophy and Application, 1889-1931

The (D.R.C.) Mission. . . . made its greatest contribution at the village level. Its aim has always been to establish a local church which would be self supporting, self governing... For this reason it exerted itself to teach the people to make better use of the natural resources at their very doors. ... At the heart of the story of the D.R.C.M. lies its aim: (the production of) a Bible-loving, industrious and prosperous peasantry.'
A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission.

BACKGROUND
A short battery of physical performance tests was used to assess lower extremity function in more than 5,000 persons age 71 years and older in three communities.


METHODS
Balance, gait, strength, and endurance were evaluated by examining ability to stand with the feet together in the side-by-side, semi-tandem, and tandem positions, time to walk 8 feet, and time to rise from a chair and return to the seated position 5 times.


RESULTS
A wide distribution of performance was observed for each test. Each test and a summary performance scale, created by summing categorical rankings of performance on each test, were strongly associated with self-report of disability. Both self-report items and performance tests were independent predictors of short-term mortality and nursing home admission in multivariate analyses. However, evidence is presented that the performance tests provide information not available from self-report items. Of particular importance is the finding that in those at the high end of the functional spectrum, who reported almost no disability, the performance test scores distinguished a gradient of risk for mortality and nursing home admission. Additionally, within subgroups with identical self-report profiles, there were systematic differences in physical performance related to age and sex.


CONCLUSION
This study provides evidence that performance measures can validly characterize older persons across a broad spectrum of lower extremity function. Performance and self-report measures may complement each other in providing useful information about functional status.
A preliminary study on the efficacy and influencing factors of interferon for the treatment of genotype 1 chronic hepatitis C with different dosage forms.

BACKGROUND AND OBJECTIVE
Nowadays, interferon alfa-2b is still in widespread use for the treatment of chronic hepatitis C in China. In this study, peginterferon alfa-2a plus ribavirin was compared with interferon alfa-2b plus ribavirin for the initial treatment of genotype 1 chronic hepatitis C.


MATERIALS AND METHODS
Overall, 168 patients with genotype 1 chronic hepatitis C were assigned peginterferon alfa-2a (135-180 µg subcutaneously/week) plus ribavirin (800-1200 mg/day orally) or interferon alfa-2b (300-500 million units, once every other day) plus ribavirin (800-1200 mg/day). According to HCV RNA levels at weeks 4 and 12, patients were reallocated to receive different interferon dosage forms or different courses of treatment. The primary endpoint was a sustained virological response (SVR).


RESULTS
A total of 160 patients completed the entire study and eight cases were lost to follow-up. The SVR rates in patients treated with peginterferon alfa-2a plus ribavirin for 24 and 48 weeks were 67.9% (53/78) and 73.6% (14/19), respectively, whereas in patients treated with interferon alfa-2b plus ribavirin for 24 and 48 weeks the SVR rates were 52.4% (43/82) and 40% (8/20), respectively. The SVR rates in the groups with a rapid virological response (RVR) and without RVR were 68.8 and 16.9%, respectively. The SVR rates in the groups with an early virological response (EVR) and in the groups without EVR were 88.1 and 10.5%, respectively.


CONCLUSION
Peginterferon alfa-2a plus ribavirin was more effective than interferon alfa-2b plus ribavirin, with similar safety. RVR can predict a greater chance of SVR. The duration of treatment should be shortened for patients with RVR. Treatment for patients without EVR should be discontinued.
Update on the Preventive Antibiotics in Stroke Study (PASS): a randomised controlled phase 3 clinical trial

BACKGROUND
Stroke is a leading cause of death worldwide. Infections after stroke occur in 30% of stroke patients and are strongly associated with unfavourable outcome. Preventive antibiotic therapy lowers infection rate in patients after stroke, however, the effect of preventive antibiotic treatment on functional outcome after stroke has not yet been investigated.The Preventive Antibiotics in Stroke Study (PASS) is an ongoing, multicentre, prospective, randomised, open-label, blinded end point trial of preventive antibiotic therapy in acute stroke. Patients are randomly assigned to either ceftriaxone at a dose of 2 g, given every 24 hours intravenously for four-days, in addition to stroke-unit care, or standard stroke-unit care without preventive antibiotic therapy. Aim of the study is to assess whether preventive antibiotic treatment improves functional outcome at three months by preventing infections.


RESULTS
To date, 2,470 patients have been included in PASS. Median stroke severity of the first 2,133 patients (second interim analysis) is 5 (IQR 3 to 9) on the National Institutes of Health Stroke Scale (NIHSS). Due to the PROBE design, no outcome data are available yet. In the initial trial protocol we proposed a dichotomisation of the mRS as primary analysis of outcome and ordinal regression analysis as secondary analysis of primary outcome, requiring a sample size of 3,200 patients. However, ordinal analysis of outcome data is becoming increasingly more common in acute stroke trials, as it increases statistical power. For PASS, funding is insufficient for inclusion of 3,200 patients with the overall inclusion rate of 15 patients per week. Therefore we change the analysis of our primary outcome from dichotomisation to ordinal regression analysis on the mRS. Power analysis showed that with similar assumptions 2,550 patients are needed using ordinal regression analysis. We expect to complete follow-up in June 2014. A full statistical analysis plan will be submitted for publication before treatment allocation will be unblinded.


CONCLUSION
The data from PASS will establish whether preventive antibiotic therapy in acute stroke improves functional outcome by preventing infection. In this update, we changed our primary outcome analysis from dichotomisation to ordinal regression analysis.


TRIAL REGISTRATION
Current controlled trials; ISRCTN66140176. Date of registration: 6 April 2010.