LLukas22/scidocs huggingface dataset:
Current imaging of childhood urinary infections: prospective survey.

OBJECTIVES
To assess whether ultrasonography alone is adequate for routine screening of childhood urinary infection, whether clinical features determine the need for further investigations, and which investigations are most appropriate.


DESIGN
Prospective survey of children with proved urinary infection and a preinvestigation record of clinical features. Ultrasonography and intravenous urography were routine, with choice of further studies determined by ultrasonographic findings.


SETTING
A children's hospital and two district general hospitals in Mersey region.


MAIN OUTCOME MEASURES
Sensitivity and specificity of ultrasonography both generally and in relation to clinical features. Accuracy of intravenous urography compared with radioisotope examinations.


RESULTS
Specificity of ultrasonography was good (99% (95% confidence interval 96% to 100%)) but sensitivity modest (43% (32% to 55%)), principally with respect to detecting vesicoureteric reflux and renal scarring. Among older children (aged 2-10 years) with positive ultrasound results and fever or vomiting the sensitivity in detecting reflux (with and without renal scarring) was 78% (62% to 89%) and the specificity 69% (60% to 78%); in detecting renal scarring (with and without reflux) the sensitivity was 100% (80% to 100%) and specificity 65% (56% to 74%). Renal scarring and obstructive uropathies were better assessed by radioisotope examinations than by intravenous urography.


CONCLUSIONS
Ultrasonography alone is inadequate for routine screening of childhood urinary infection. Though further investigations remain advisable in infants, in older children they can be restricted to a minority who have positive ultrasound examinations or have had fever or vomiting. Radioisotope examinations largely eliminate the need for intravenous urography.
Credit Card Fraud Detection through Parenclitic Network Analysis

1Department of Computer Science, Faculty of Science and Technology, Universidade Nova de Lisboa, Lisboa, Portugal 2Center for Biomedical Technology, Universidad Politécnica de Madrid, 28223 Pozuelo de Alarcón, Madrid, Spain 3Data, Networks and Cybersecurity Research Institute, Univ. Rey Juan Carlos, 28028 Madrid, Spain 4Department of Applied Mathematics, Universidad Rey Juan Carlos, 28933 Móstoles, Madrid, Spain 5Center for Computational Simulation, 28223 Pozuelo de Alarcón, Madrid, Spain 6Cyber Security & Digital Trust, BBVA Group, 28050 Madrid, Spain
Professionalism and Test-Driven Development

Test-driven development is a discipline that helps professional software developers ship clean, flexible code that works, on time. In this article, the author discusses how test-driven development can help software developers achieve a higher degree of professionalism
Coordinated school health programs and academic achievement: a systematic review of the literature.

BACKGROUND
Few evaluations of school health programs measure academic outcomes. K-12 education needs evidence for academic achievement to implement school programs. This article presents a systematic review of the literature to examine evidence that school health programs aligned with the Coordinated School Health Program (CSHP) model improve academic success.


METHODS
A multidisciplinary panel of health researchers searched the literature related to academic achievement and elements of the CSHP model (health services, counseling/social services, nutrition services, health promotion for staff, parent/family/community involvement, healthy school environment, physical education, and health education) to identify scientifically rigorous studies of interventions. Study designs were classified according to the analytic framework provided in the Guide developed by the Community Preventive Services Task Force.


RESULTS
The strongest evidence from scientifically rigorous evaluations exists for a positive effect on some academic outcomes from school health programs for asthmatic children that incorporate health education and parental involvement. Strong evidence also exists for a lack of negative effects of physical education programs on academic outcomes. Limited evidence from scientifically rigorous evaluations support the effect of nutrition services, health services, and mental health programs, but no such evidence is found in the literature to support the effect of staff health promotion programs or school environment interventions on academic outcomes.


CONCLUSIONS
Scientifically rigorous evaluation of school health programs is challenging to conduct due to issues related to sample size, recruitment, random assignment to condition, implementation fidelity, costs, and adequate follow-up time. However, school health programs hold promise for improving academic outcomes for children.
Reliability of leg muscle electromyography in vertical jumping

In this study we aimed to determine the reliability of the surface electromyography (EMG) of leg muscles during vertical jumping between two test sessions, held 2 weeks apart. Fifteen females performed three maximal vertical jumps with countermovement. The displacement of the body centre of mass (BCM), duration of propulsion phase (time), range of motion (ROM) and angular velocity of the knee and surface EMG of four leg muscles (rectus femoris, vastus medialis, biceps femoris and gastrocnemius) were recorded during the jumps. All variables were analysed throughout the propulsion and mid-propulsion phases. Intraclass correlation coefficients (ICC) for the rectus femoris, vastus medialis, biceps femoris and gastrocnemius were calculated to be 0.88, 0.70, 0.24 and 0.01, respectively. BCM, ROM and time values all indicated ICC values greater than 0.90, and the mean knee angular velocity was slightly lower, at 0.75. ICCs between displacement of the BCM and integrated EMG (IEMG) of the muscles studied were less than 0.50. The angular velocity of the knee did not correlate well with muscle activity. Factors that may have affected reliability were variations in the position of electrode replacement, skin resistance, cross-talk between muscles and jump mechanics. The results of this study suggest that while kinematic variables are reproducible over successive vertical jumps, the degree of repeatability of an IEMG signal is dependent upon the muscle studied.
Visualizing Scholarly Publications and Citations to Enhance Author Profiles

With data on scholarly publications becoming more abundant and accessible, there exist new opportunities for using this information to provide rich author profiles to display and explore scholarly work. We present a pair of linked visualizations connected to the Microsoft Academic Graph that can be used to explore the publications and citations of individual authors. We provide an online application with which a user can manage collections of papers and generate these visualizations.
Continuous interferon-α2b infusion in combination with ribavirin for chronic hepatitis C in treatment-experienced patients.

BACKGROUND
Sustained virological response (SVR) rates in previous non-responders to pegylated interferon (PEG-IFN)-α and ribavirin for chronic HCV remain low (~10%). We hypothesize that continuous subcutaneous delivery of fully potent interferon (IFN)-α2b via an external pump will lead to stable blood concentrations and thereby prevent subtherapeutic trough levels associated with viral breakthrough. The aims of the study were to assess safety, tolerability and virological response in patients who were previous PEG-IFN-α/ribavirin non-responders.


METHODS
We randomized 30 HCV genotype 1 (n=24) and genotype 4 (n=6) patients to receive 6, 9 or 12 million units (MU) IFN-α2b daily by continuous subcutaneous administration using an insulin pump (MiniMed(®) 508; Medtronic Inc., Minneapolis, MN, USA) in combination with ribavirin (1,000-1,600 mg) for 48 weeks.


RESULTS
The magnitude of viral decline in the 12 MU group after 4 weeks of treatment was 2.67 log HCV RNA compared with 1.21 and 1.27 log HCV RNA in the 9 and 6 MU groups, respectively (P=0.001). In the intention-to-treat analysis, the SVR rate was 20% (6/30). The per-protocol SVR rate was 25% (6/24), of which four out of six patients in the high-dose arm achieved SVR. Adverse events appeared dose-dependent, were mostly mild-to-moderate and were typical of IFN therapy. Five patients developed irritation and/or abscesses at the injection site. Six serious adverse events were reported in five patients.


CONCLUSIONS
Continuous delivery of IFN-α2b can induce a strong dose-dependent viral suppression. This could be an effective approach in conjunction with, or as lead-in therapy prior to, treatment with a direct antiviral agent.
Study protocol for Young & Strong: a cluster randomized design to increase attention to unique issues faced by young women with newly diagnosed breast cancer

BACKGROUND
Each year, approximately 11% of women diagnosed with breast cancer in the United States are 45 years of age or younger. These women have concerns specific to or accentuated by their age, including fertility-related concerns, and have higher rates of psychosocial distress than women diagnosed at older ages. Current guidelines recommend that fertility risks be considered early in all treatment plans; however, the extant research indicates that attention to fertility by the healthcare team is limited. Importantly, attention to fertility may be a proxy for whether or not other important issues warranting attention in younger women with breast cancer are addressed, including genetic risks, psychosocial distress, sexual functioning, and body image concerns. The Young & Strong study tests the efficacy of an intervention designed for young women recently diagnosed with breast cancer and their oncologists with the intention to: 1) increase attention to fertility as an important surrogate for other issues facing young women, 2) educate and support young women and their providers, and 3) reduce psychosocial distress among young women with breast cancer.


METHODS/DESIGN
The study employs a cluster randomized design including 14 academic institutions and 40 community sites across the U.S. assigned to either the study intervention arm or contact-time comparison intervention arm. Academic institutions enroll up to 15 patients per site while community sites enroll up to 10 patients. Patient eligibility requirements include: an initial diagnosis of stage I-III invasive breast cancer within three months prior, without a known recurrence or metastatic breast cancer; 18-45 years of age at diagnosis; ability to read and write in English. The primary outcome is oncologists' attention to fertility concerns as determined by medical record review. Secondary outcomes include differences in patient satisfaction with care and psychosocial distress between the two study arms.


DISCUSSION
Study findings will provide valuable insight into how to increase attention to fertility and other issues specific to young women with breast cancer and how to improve doctor-patient communication around these issues, which may promote better quality of care for this population.


TRIAL REGISTRATION
NCT01647607. Registered July 19, 2012.
Review and analysis of augmented reality literature for construction industry

Research has identified various beneficial capabilities for augmented reality technologies in the AEC industry such as virtual site visits, comparing as-built and as-planned status of projects, pre-empting schedule disputes, enhancing collaboration opportunities, and planning/training for similar projects. This paper provides an expanded foundation for future research by presenting a statistical review of augmented reality technology in the AEC industry. The review is based on articles found within eight well-known journals in architecture, engineering, construction, and facility management (AEC/FM) until the end of the year 2012. The review further narrows the literature within these journals by considering only those 133 articles found through a key word search for “augmented reality.” The selected journal articles are classified within the following dimensions: improvement focus, industry sector, target audience, project phase, stage of technology maturity, application area, comparison role, and technology. The number of articles within these dimensions are used to identify maturing and emerging trends in the literature as well as to synthesize the current state-of-the-art of augmented reality research in the AEC industry. In summary, the AR literature has increasingly focused on the demonstration of visualization and simulation applications for comparison of as-planned versus as-built statuses of the project during the construction phase to monitor project progress and address issues faced by field workers. In addition, the future trend is toward using web-based mobile augmented systems for field construction monitoring.
Enteral levodopa/carbidopa infusion in advanced Parkinson disease: long-term exposure.

OBJECTIVES
In patients with advanced Parkinson disease, levodopa/carbidopa formulated as a gel suspension (Duodopa) permits continuous delivery into the small intestine using a portable pump, resulting in less variability in levodopa concentrations and fewer motor fluctuations and dyskinesias than with oral levodopa administration. This is a retrospective analysis of the long-term clinical experience with this agent.


METHODS
All but 1 of the patients who had received enteral levodopa infusion treatment between January 1, 1991, and June 30, 2002, consented to a review of their hospital charts.


RESULTS
Of the 65 patients with initial testing of the treatment, 86% opted for continued treatment via percutaneous endoscopic gastrostomy or gastrojejunostomy. Total exposure to levodopa infusion was 216 patient-years (mean, 3.7 years). Maximum treatment duration was 10.7 years. Fifty-two patients were treated for 1 year or longer. The adverse effect profile of levodopa/carbidopa infusion was similar to that observed with oral administration of levodopa. Seven deaths occurred, all considered unrelated to the treatment. Intestinal tube problems, including dislocation of the intestinal tube to the stomach, were the most common technical problem, occurring in 69% of the patients during the first year. The optimal daily dose of levodopa decreased by an average of 5% during follow-up.


CONCLUSIONS
The safety of enteral infusion of levodopa/carbidopa formulated as a gel suspension was found acceptable. For most patients, the technical challenges posed by the enteral infusion system were offset by the improvement in motor fluctuations and dyskinesias offered by this technique.
Uptake, outcomes, and costs of implementing non-invasive prenatal testing for Down’s syndrome into NHS maternity care: prospective cohort study in eight diverse maternity units

OBJECTIVE
 To investigate the benefits and costs of implementing non-invasive prenatal testing (NIPT) for Down's syndrome into the NHS maternity care pathway.


DESIGN
 Prospective cohort study.


SETTING
 Eight maternity units across the United Kingdom between 1 November 2013 and 28 February 2015.


PARTICIPANTS
 All pregnant women with a current Down's syndrome risk on screening of at least 1/1000.


MAIN OUTCOME MEASURES
 Outcomes were uptake of NIPT, number of cases of Down's syndrome detected, invasive tests performed, and miscarriages avoided. Pregnancy outcomes and costs associated with implementation of NIPT, compared with current screening, were determined using study data on NIPT uptake and invasive testing in combination with national datasets.


RESULTS
 NIPT was prospectively offered to 3175 pregnant women. In 934 women with a Down's syndrome risk greater than 1/150, 695 (74.4%) chose NIPT, 166 (17.8%) chose invasive testing, and 73 (7.8%) declined further testing. Of 2241 women with risks between 1/151 and 1/1000, 1799 (80.3%) chose NIPT. Of 71 pregnancies with a confirmed diagnosis of Down's syndrome, 13/42 (31%) with the diagnosis after NIPT and 2/29 (7%) after direct invasive testing continued, resulting in 12 live births. In an annual screening population of 698 500, offering NIPT as a contingent test to women with a Down's syndrome screening risk of at least 1/150 would increase detection by 195 (95% uncertainty interval -34 to 480) cases with 3368 (2279 to 4027) fewer invasive tests and 17 (7 to 30) fewer procedure related miscarriages, for a non-significant difference in total costs (£-46 000, £-1 802 000 to £2 661 000). The marginal cost of NIPT testing strategies versus current screening is very sensitive to NIPT costs; at a screening threshold of 1/150, NIPT would be cheaper than current screening if it cost less than £256. Lowering the risk threshold increases the number of Down's syndrome cases detected and overall costs, while maintaining the reduction in invasive tests and procedure related miscarriages.


CONCLUSIONS
 Implementation of NIPT as a contingent test within a public sector Down's syndrome screening programme can improve quality of care, choices for women, and overall performance within the current budget. As some women use NIPT for information only, the Down's syndrome live birth rate may not change significantly. Future research should consider NIPT uptake and informed decision making outside of a research setting.
Protection of major groundwater resources : a computer based management tool for Swedish conditions

Protection of major groundwater resources : a computer based management tool for Swedish conditions
Introducing categories to the practicing physicist

We argue that category theory should become a part of the daily practice of the physicist, and more specific, the quantum physicist and/or informatician. The reason for this is not that category theory is a better way of doing mathematics, but that monoidal categories constitute the actual algebra of practicing physics. We will not provide rigorous definitions or anything resembling a coherent mathematical theory, but we will take the reader for a journey introducing concepts which are part of category theory in a manner that the physicist will recognize them. 1 Why? Why would a physicist care about category theory, why would he want to know about it, why would he want to show off with it? There could be many reasons. For example, you might find John Baez’s webside one of the coolest in the world. Or you might be fascinated by Chris Isham’s and Lee Smolin’s ideas on the use of topos theory in Quantum Gravity. Also the connections between knot theory, braided categories, and sophisticated mathematical physics such as quantum groups and topological quantum field theory might lure you. Or, if you are also into pure mathematics, you might just appreciate category theory due to its incredible unifying power of mathematical structures and constructions. But there is a far more on-the-nose reason which is never mentioned. Namely, a category is the exact mathematical structure of practicing physics! What do I mean here by a practicing physics? Consider a physical system of type A (e.g. a qubit, or two qubits, or an electron, or classical measurement data) and perform an operation f on it (e.g. perform a measurement on it) which results in a system possibly of a different type B (e.g. the system together with classical data which encodes the measurement outcome, or, just classical data in the case that the measurement destroyed the system). So typically we have
Optimal Pulsewidth Modulation for Common-Mode Voltage Elimination Scheme of Medium-Voltage Modular Multilevel Converter-Fed Open-End Stator Winding Induction Motor Drives

Multilevel converter topologies for open-end stator winding medium-voltage (MV) induction motor drives have been researched from the last two decades. In this paper, a dual n-level modular multilevel converter (MMC) topology has been proposed for open-end stator winding MV induction motor drives. The control requirements of the proposed system are low device switching frequency, minimal harmonic distortion of machine stator currents, elimination of common-mode voltages in machine stator windings, and maintaining floating capacitor voltages around their nominal value. Based on these requirements, an emerging modulation technique for MV induction motor drives known as synchronous optimal pulsewidth modulation has been developed for the proposed dual nL-MMC topology. The laboratory measurements from a dual three-level MMC fed 1.5-kW open-end stator winding induction motor drive demonstrate the performance of proposed technique.
Assessment of Right Ventricular Afterload in COPD.

BACKGROUND
We aimed to study whether pulmonary hypertension (PH) and elevated pulmonary vascular resistance (PVR) could be predicted by conventional echo Doppler and novel tissue Doppler imaging (TDI) in a population of chronic obstructive pulmonary disease (COPD) free of LV disease and co-morbidities.


METHODS
Echocardiography and right heart catheterization was performed in 100 outpatients with COPD. By echocardiography the time-integral of the TDI index, right ventricular systolic velocity (RVSmVTI) and pulmonary acceleration-time (PAAcT) were measured and adjusted for heart rate. The COPD patients were randomly divided in a derivation (n = 50) and a validation cohort (n = 50).


RESULTS
PH (mean pulmonary artery pressure (mPAP) ≥ 25mmHg) and elevated PVR ≥ 2Wood unit (WU) were predicted by satisfactory area under the curve for RVSmVTI of 0.93 and 0.93 and for PAAcT of 0.96 and 0.96, respectively. Both echo indices were 100% feasible, contrasting 84% feasibility for parameters relying on contrast enhanced tricuspid-regurgitation. RVSmVTI and PAAcT showed best correlations to invasive measured mPAP, but less so to PVR. PAAcT was accurate in 90- and 78% and RVSmVTI in 90- and 84% in the calculation of mPAP and PVR, respectively.


CONCLUSIONS
Heart rate adjusted-PAAcT and RVSmVTI are simple and reproducible methods that correlate well with pulmonary artery pressure and PVR and showed high accuracy in detecting PH and increased PVR in patients with COPD. Taken into account the high feasibility of these two echo indices, they should be considered in the echocardiographic assessment of COPD patients.