LLukas22/scidocs huggingface dataset:
Effects of 35% Carbamide Peroxide Gel on Surface Roughness and Hardness of Composite Resins

OBJECTIVE
Bleaching agents may not be safe for dental materials. The purpose of this in-vitro study was to evaluate the effects of Opalescent Quick "in-office bleaching gel" containing 35% carbamide peroxide on the surface roughness and hardness of microfilled (Heliomolar) and hybride (Spectrum TPH) composite resins.


MATERIALS AND METHODS
Twenty specimens of Spectrum TPH composite resins and twenty Heliomolar composite resins were fabricated using a metallic ring (6.5 mm diameter and 2.5 mm thickness) and light cured, then their surfaces were polished. Specimens of each composite resin were divided into two equal groups. Ten specimens of each type of composite were stored in water at 37°C as the control groups and 35% carbamide peroxide gel (Opalescence Quick) as the other group for 30 minutes a week for 3 weeks. Then the specimens were subject to roughness and hardness tests.


RESULTS
This study revealed that using 35% carbamide peroxide bleaching gels had no significant effect on the surface roughness of Spectrum TPH "hybrid" and Heliomolar "microfilled" composite resins. The surface hardness of Spectrum TPH composite treated with the subject gel significantly increased compared to heliomolar, which had no significant change after treatment with this bleaching gel.


CONCLUSION
If tooth color matching of the composite had been satisfactory after office bleaching with 35% carbamide peroxide gel, this material would have been acceptable because it has no adverse effect on Heliomolar and Spectrum TPH composite resins.
Predicting and explaining the adoption of online trading: An empirical study in Taiwan

Article history: This study investigates hows Received 25 December 2007 Received in revised form 28 January 2009 Accepted 9 February 2009 Available online 21 February 2009
LoRaWAN — A low power WAN protocol for Internet of Things: A review and opportunities

The Internet of Things (IoT) vision requires increasingly more sensor nodes interconnected and a network solution that may accommodate these requirements accordingly. In wireless sensor networks, there are energy-limited devices; therefore techniques to save energy have become a significant research trend. Other issues such as latency, range coverage, and bandwidth are important aspects in IoT. It is considering the massive number of expected nodes connected to the Internet. The LoRaWAN (Low Power WAN Protocol for Internet of Things), a data-link layer with long range, low power, and low bit rate, appeared as a promising solution for IoT in which, end-devices use LoRa to communicate with gateways through a single hop. While proprietary LPWAN (Low Power Wide Area Network) technologies are already hitting a large market, this paper addresses the LoRa architecture and the LoRaWAN protocol that is expected to solve the connectivity problem of tens of billions of devices in the next decade. Use cases are considered to illustrate its application alongside with a discussion about open issues and research opportunities.
Communication breakdown in the outpatient referral process

OBJECTIVE: To evaluate primary care and specialist physicians’ satisfaction with interphysician communication and to identify the major problems in the current referral process. DESIGN: Surveys were mailed to providers to determine satisfaction with the referral process; then patient-specific surveys were e-mailed to this group to obtain real-time referral information. SETTING: Academic tertiary care medical center. PARTICIPANTS: Attending-level primary care physicians (PCPs) and specialists. MEASUREMENTS AND MAIN RESULTS: The response rate for mail surveys for PCPs was 57% and for specialists was 51%. In the mail survey, 63% of PCPs and 35% of specialists were dissatisfied with the current referral process. Respondents felt that major problems with the current referral system were lack of timeliness of information and inadequate referral letter content. Information considered important by recipient groups was often not included in letters that were sent. The response rate for the referral specific e-mail surveys was 56% for PCPs and 53% for specialists. In this e-mail survey, 68% of specialists reported that they received no information from the PCP prior to specific referral visits, and 38% of these said that this information would have been helpful. In addition, four weeks after specific referral visits, 25% of PCPs had still not received any information from specialists. CONCLUSIONS: Substantial problems were present in the referral process. The major issues were physician dissatisfaction, lack of timeliness, and inadequate content of interphysician communication. Information obtained from the general survey and referral-specific survey was congruent. Efforts to improve the referral system could improve both physician satisfaction and quality of patient care.
Mutations in WNT10B Are Identified in Individuals with Oligodontia.

Tooth agenesis is one of the most common developmental anomalies in humans. Oligodontia, a severe form of tooth agenesis, is genetically and phenotypically a heterogeneous condition. Although significant efforts have been made, the genetic etiology of dental agenesis remains largely unknown. In the present study, we performed whole-exome sequencing to identify the causative mutations in Chinese families in whom oligodontia segregates with dominant inheritance. We detected a heterozygous missense mutation (c.632G>A [p.Arg211Gln]) in WNT10B in all affected family members. By Sanger sequencing a cohort of 145 unrelated individuals with non-syndromic oligodontia, we identified three additional mutations (c.569C>G [p.Pro190Arg], c.786G>A [p.Trp262(∗)], and c.851T>G [p.Phe284Cys]). Interestingly, analysis of genotype-phenotype correlations revealed that mutations in WNT10B affect the development of permanent dentition, particularly the lateral incisors. Furthermore, a functional assay demonstrated that each of these mutants could not normally enhance the canonical Wnt signaling in HEPG2 epithelial cells, in which activity of the TOPFlash luciferase reporter was measured. Notably, these mutant WNT10B ligands could not efficiently induce endothelial differentiation of dental pulp stem cells. Our findings provide the identification of autosomal-dominant WNT10B mutations in individuals with oligodontia, which increases the spectrum of congenital tooth agenesis and suggests attenuated Wnt signaling in endothelial differentiation of dental pulp stem cells.
Development and Psychometric Testing of the Turkish-Version Oral Chemotherapy Adherence Scale.

BACKGROUND
To ensure the quality of patient care, the bioavailability of drugs, and the success of the treatment, it is imperative that nurses evaluate the adherence of patients to pharmaceutical treatments using standard measurement tools that are integrated into the treatment process. No scale that uses psychometric analyses to evaluate this adherence in patients who are on oral chemotherapy is currently available.


PURPOSE
This study developed and tested the validity and reliability of a Turkish version of the standardized Oral Chemotherapy AdherenceScale (OCAS), a tool that may be used by healthcare personnel to better evaluate patient adherence to their therapies.


METHODS
We developed and examined the validity and reliability of the OCAS using a sample of 306 patients with cancer who were receiving oral chemotherapy. A literature review was conducted to generate the items. An expert panel evaluated content validity; preimplementation was used to evaluate face validity, factor analysis was used to evaluate construct validity, and criterion validity was evaluated using the Medication Adherence Self-Efficacy Scale.


RESULTS
The Cronbach's alpha calculated for OCAS (19 items) was .738. A highly significant and positive correlation was observed between the test-retest scores of the participants. A positive significant correlation was observed between the total scores of the participants obtained from OCAS and Medication Adherence Self-Efficacy Scale. As a result of the factor analysis performed for the construct validity of the scale, three factors were defined that accounted for approximately 43% of the total variance.


CONCLUSIONS/IMPLICATIONS FOR PRACTICE
The OCAS has acceptable psychometric properties and is appropriate for use in research and clinical practice settings to evaluate patient adherence to their therapies.
Vital Crises in Italian Cinema: Iconography, Stylistics, Politics

Preface 1. Introduction 2. Rossellini's Resistance 3. Visconti: The National Language, Dialect, and the Southern Question 4. De Sica's and Zavattini's Neopopulism 5. Between the Vital Crises 6. Annus Mirabilis 7. Antonioni's Psychoanalysis of the "Boom" 8. New Wave Neorealism: Pasolini, Olmi, Rosi 9. Conclusion Notes Index
Morphine delays and attenuates ticagrelor exposure and action in patients with myocardial infarction: the randomized, double-blind, placebo-controlled IMPRESSION trial

AIMS
The currently available data indicate a drug-drug interaction between morphine and oral P2Y12 receptor inhibitors, when administered together. The aim of this trial was to assess the influence of infused morphine on pharmacokinetics and pharmacodynamics of ticagrelor and its active metabolite (AR-C124910XX) in patients with acute myocardial infarction.


METHODS AND RESULTS
In a single-centre, randomized, double-blind trial, patients were assigned in a 1:1 ratio to receive intravenously either morphine (5 mg) or placebo, followed by a 180 mg loading dose of ticagrelor. Pharmacokinetics was determined with liquid chromatography tandem mass spectrometry and ticagrelor antiplatelet effects were measured with up to three different platelet function tests: vasodilator-stimulated phosphoprotein phosphorylation assay, multiple electrode aggregometry and VerifyNow. The pharmacokinetic and pharmacodynamic assessment was performed in 70 patients (35 in each study group). Morphine lowered the total exposure to ticagrelor and its active metabolite by 36% (AUC(0-12): 6307 vs. 9791 ng h/mL; P = 0.003), and 37% (AUC(0-12): 1503 vs. 2388 ng h/mL; P = 0.008), respectively, with a concomitant delay in maximal plasma concentration of ticagrelor (4 vs. 2 h; P = 0.004). Multiple regression analysis showed that lower AUC(0-12) values for ticagrelor were independently associated with the administration of morphine (P = 0.004) and the presence of ST-segment elevation myocardial infarction (P = 0.014). All three methods of platelet reactivity assessment showed a stronger antiplatelet effect in the placebo group and a greater prevalence of high platelet reactivity in patients receiving morphine.


CONCLUSIONS
Morphine delays and attenuates ticagrelor exposure and action in patients with myocardial infarction. ClinicalTrials.gov Identifier: NCT02217878.
Nurses' practice environment and satisfaction with schedule flexibility is related to intention to leave due to dissatisfaction: A multi-country, multilevel study.

BACKGROUND
Nursing turnover is a major issue for health care managers, notably during the global nursing workforce shortage. Despite the often hierarchical structure of the data used in nursing studies, few studies have investigated the impact of the work environment on intention to leave using multilevel techniques. Also, differences between intentions to leave the current workplace or to leave the profession entirely have rarely been studied.


OBJECTIVE
The aim of the current study was to investigate how aspects of the nurse practice environment and satisfaction with work schedule flexibility measured at different organisational levels influenced the intention to leave the profession or the workplace due to dissatisfaction.


DESIGN
Multilevel models were fitted using survey data from the RN4CAST project, which has a multi-country, multilevel, cross-sectional design. The data analysed here are based on a sample of 23,076 registered nurses from 2020 units in 384 hospitals in 10 European countries (overall response rate: 59.4%). Four levels were available for analyses: country, hospital, unit, and individual registered nurse. Practice environment and satisfaction with schedule flexibility were aggregated and studied at the unit level. Gender, experience as registered nurse, full vs. part-time work, as well as individual deviance from unit mean in practice environment and satisfaction with work schedule flexibility, were included at the individual level. Both intention to leave the profession and the hospital due to dissatisfaction were studied.


RESULTS
Regarding intention to leave current workplace, there is variability at both country (6.9%) and unit (6.9%) level. However, for intention to leave the profession we found less variability at the country (4.6%) and unit level (3.9%). Intention to leave the workplace was strongly related to unit level variables. Additionally, individual characteristics and deviance from unit mean regarding practice environment and satisfaction with schedule flexibility were related to both outcomes. Major limitations of the study are its cross-sectional design and the fact that only turnover intention due to dissatisfaction was studied.


CONCLUSIONS
We conclude that measures aiming to improve the practice environment and schedule flexibility would be a promising approach towards increased retention of registered nurses in both their current workplaces and the nursing profession as a whole and thus a way to counteract the nursing shortage across European countries.
OIL: An Ontology Infrastructure for the Semantic Web

have investigated them. More recently, the notion of an ontology is becoming widespread in fields such as intelligent information integration, cooperative information systems, information retrieval, electronic commerce, and knowledge management. Ontologies are becoming popular largely because of what they promise: a shared and common understanding that reaches across people and application systems. Currently, ontologies applied to the World Wide Web are creating the Semantic Web.1 Originally, the Web grew mainly around HTML, which provides a standard for structuring documents that browsers can translate in a canonical way to render those documents. On the one hand, HTML’s simplicity helped spur the Web’s fast growth; on the other, its simplicity seriously hampered more advanced Web applications in many domains and for many tasks. This led to XML (see Figure 1), which lets developers define arbitrary domainand task-specific extensions (even HTML appears as an XML application— XHTML). XML is basically a defined way to provide a serialized syntax for tree structures—it is an important first step toward building a Semantic Web, where application programs have direct access to data semantics. The resource description framework2 has taken an important additional step by defining a syntactical convention and a simple data model for representing machine-processable data semantics. RDF is a standard for the Web metadata the World Wide Web Consortium (www.w3c.org/rdf) develops, and it defines a data model based on triples: object, property, and value. The RDF Schema3 takes a step further into a richer representation formalism and introduces basic ontological modeling primitives into the Web. With RDFS, we can talk about classes, subclasses, subproperties, domain and range restrictions of properties, and so forth in a Web-based context. We took RDFS as a starting point and enriched it into a full-fledged Web-based ontology language called OIL.4 We included these aspects:
Liveness Detection for Embedded Face Recognition System

To increase reliability of face recognition system, the system must be able to distinguish real face from a copy of face such as a photograph. In this paper, we propose a fast and memory efficient method of live face detection for embedded face recognition system, based on the analysis of the movement of the eyes. We detect eyes in sequential input images and calculate variation of each eye region to determine whether the input face is a real face or not. Experimental results show that the proposed approach is competitive and promising for live face detection. Keywords—Liveness Detection, Eye detection, SQI.
A Randomized, Open-Label, Multicenter Trial for the Safety and Efficacy of Adult Mesenchymal Stem Cells after Acute Myocardial Infarction

Recent studies suggest that the intracoronary administration of bone marrow (BM)-derived mesenchymal stem cells (MSCs) may improve left ventricular function in patients with acute myocardial infarction (AMI). However, there is still argumentative for the safety and efficacy of MSCs in the AMI setting. We thus performed a randomized pilot study to investigate the safety and efficacy of MSCs in patients with AMI. Eighty patients with AMI after successful reperfusion therapy were randomly assigned and received an intracoronary administration of autologous BM-derived MSCs into the infarct related artery at 1 month. During follow-up period, 58 patients completed the trial. The primary endpoint was changes in left ventricular ejection fraction (LVEF) by single-photon emission computed tomography (SPECT) at 6 month. We also evaluated treatment-related adverse events. The absolute improvement in the LVEF by SPECT at 6 month was greater in the BM-derived MSCs group than in the control group (5.9% ± 8.5% vs 1.6% ± 7.0%; P=0.037). There was no treatment-related toxicity during intracoronary administration of MSCs. No significant adverse cardiovascular events occurred during follow-up. In conclusion, the intracoronary infusion of human BM-derived MSCs at 1 month is tolerable and safe with modest improvement in LVEF at 6-month follow-up by SPECT. (ClinicalTrials.gov registration number: NCT01392105).
Prevalence and Correlates of Physical Inactivity in Community-Dwelling Older Adults in Ireland

The public health challenges associated with rapid population ageing are likely to be exacerbated by poor physical activity levels. The purpose of this study was to identify correlates of physical inactivity in a population-representative sample of older adults in Ireland. This paper reports a secondary analysis of data from 4892 adults aged 60+ from the Irish Longitudinal Study on Ageing (TILDA). TILDA includes an assessment of the mental and physical health, and social and financial circumstances of participants assessed in a home interview and self-completion questionnaire. Chi squared statistics and forced entry logistic regression were used to identify factors associated with physical inactivity. Females were over twice as likely to be inactive as their male counterparts (Odds Ratio 2.2). Increasing old age was associated with inactivity among males and females. Those who reported above secondary level education, no reported falls in the last year and no fear of falling were less likely to be physically inactive. While older adults who noted poor/fair self-reported health, that they did not look after grandchildren, did not own a car or did not attend a course were also more likely to be inactive than those who reported positively for these items. Gender displayed a strong but often contrasting influence on factors that affect physical activity among older adults. Among females, living alone or in a rural area, retirement, fair/poor emotional health and activity being limited by illness were all significantly associated with inactivity. While cohabiting, being employed and residing in an urban area were related to low levels of activity in males. Our findings identify specific groups of the older Irish population who may be at particular risk of physical inactivity and thereby the associated physiological and psychological hazards. These results can support the development of tailored interventions to promote healthy ageing.
The toxicology of mercury--current exposures and clinical manifestations.

s since January 1975, a full-text search capacity, and a personal archive for saving articles and search results of interest. All articles can be printed in a format that is virtually identical to that of the typeset pages. Beginning six months after publication, the full text of all Original Articles and Special Articles is available free to nonsubscribers who have completed a brief registration. Copyright © 2003 Massachusetts Medical Society. All rights reserved. Downloaded from www.nejm.org at UNIV OF CINCINNATI SERIALS DEPT on August 8, 2007 .
Comparison of darbepoetin alfa dosed weekly (QW) vs. extended dosing schedule (EDS) in the treatment of anemia in patients receiving multicycle chemotherapy in a randomized, phase 2, open-label trial

Chemotherapy-induced anemia (CIA) is responsive to treatment with erythropoiesis-stimulating agents (ESAs) such as darbepoetin alfa. Administration of ESAs on a synchronous schedule with chemotherapy administration could benefit patients by reducing clinic visits and potentially enhancing on-time chemotherapy delivery. This phase 2, 25-week, open-label study evaluated the noninferiority of darbepoetin alfa administered weekly vs. as an extended dosing schedule (every 2 or 3 weeks) in patients with CIA. Patients were randomized 1:1 to an extended dosing schedule (EDS: darbepoetin alfa 300 μg Q2W if chemotherapy was QW, Q2W, or Q4W or darbepoetin alfa 500 μg Q3W if chemotherapy was Q3W) or weekly (150 μg QW regardless of chemotherapy schedule). Stratification factors included chemotherapy cycle length, screening hemoglobin (<10 g/dL vs. ≥10 g/dL), and tumor type (lung/gynecological vs. other nonmyeloid malignancies). The primary endpoint was change in hemoglobin from baseline to Week 13. Seven hundred fifty-two patients (374 QW patients; 378 EDS patients) received ≥1 dose of darbepoetin alfa and were included in the analysis. Demographics and disease state were similar between groups. Seventy-one percent of patients in the EDS group and 76% in the QW group achieved the target hemoglobin of ≥11.0 g/dL. There was a minimal difference in the primary endpoint of mean change in hemoglobin (baseline to Week 13) between the QW and the EDS groups (-0.04 g/dL; 95% confidence interval: -0.26, 0.17 g/dL). The upper limit of the 95% confidence interval was less than the prespecified limit of <0.75 g/dL, supporting noninferiority of the EDS dosing schedule. Reported adverse events were similar between groups. A slight increase in transfusions was reported in the QW group. Darbepoetin alfa, when administered synchronously with chemotherapy, on an EDS appears to be similarly efficacious to darbepoetin alfa weekly dosing with no unexpected adverse events. This study provides prospective data on how multiple dosing regimens available with darbepoetin alfa can be synchronized with chemotherapy administered across a range of dosing schedules. ClinicalTrials.gov Identifier NCT00144131.
Weighted association based methods for the combination of heterogeneous partitions

0167-8655/$ see front matter 2011 Elsevier B.V. A doi:10.1016/j.patrec.2011.05.006 ⇑ Corresponding author. Tel.: +537 271 4787; fax: + E-mail addresses: svega@cenatav.co.cu (S. Vega-P cu (J. Ruiz-Shulcloper), aguerra@cenatav.co.cu (A. Gue Co-association matrix has been a useful tool in many clustering ensemble techniques as a similarity measure between objects. In this paper, we introduce the weighted-association matrix, which is more expressive than the traditional co-association as a similarity measure, in the sense that it integrates information from the set of partitions in the clustering ensemble as well as from the original data of object representations. The weighted-association matrix is the core of the two main contributions of this paper: a natural extension of the well-known evidence accumulation cluster ensemble method by using the weightedassociation matrix and a kernel based clustering ensemble method that uses a new data representation. These methods are compared with simple clustering algorithms as well as with other clustering ensemble algorithms on several datasets. The obtained results ratify the accuracy of the proposed algorithms. 2011 Elsevier B.V. All rights reserved.