LLukas22/scidocs huggingface dataset:
Development of an evidence-based framework of factors contributing to patient safety incidents in hospital settings: a systematic review

OBJECTIVE
The aim of this systematic review was to develop a 'contributory factors framework' from a synthesis of empirical work which summarises factors contributing to patient safety incidents in hospital settings.


DESIGN
A mixed-methods systematic review of the literature was conducted.


DATA SOURCES
Electronic databases (Medline, PsycInfo, ISI Web of knowledge, CINAHL and EMBASE), article reference lists, patient safety websites, registered study databases and author contacts.


ELIGIBILITY CRITERIA
Studies were included that reported data from primary research in secondary care aiming to identify the contributory factors to error or threats to patient safety.


RESULTS
1502 potential articles were identified. 95 papers (representing 83 studies) which met the inclusion criteria were included, and 1676 contributory factors extracted. Initial coding of contributory factors by two independent reviewers resulted in 20 domains (eg, team factors, supervision and leadership). Each contributory factor was then coded by two reviewers to one of these 20 domains. The majority of studies identified active failures (errors and violations) as factors contributing to patient safety incidents. Individual factors, communication, and equipment and supplies were the other most frequently reported factors within the existing evidence base.


CONCLUSIONS
This review has culminated in an empirically based framework of the factors contributing to patient safety incidents. This framework has the potential to be applied across hospital settings to improve the identification and prevention of factors that cause harm to patients.
FINITE FORMULATION OF THE ELECTROMAGNETIC FIELD

The objective of this paper is to present an approach to electromagnetic field simulation based on the systematic use of the global (i.e. integral) quantities. In this approach, the equations of electromagnetism are obtained directly in a finite form starting from experimental laws without resorting to the differential formulation. This finite formulation is the natural extension of the network theory to electromagnetic field and it is suitable for computational electromagnetics.
Early Clinical Outcomes After Transcatheter Aortic Valve Replacement Using a Novel Self-Expanding Bioprosthesis in Patients With Severe Aortic Stenosis Who Are Suboptimal for Surgery: Results of the Evolut R U.S. Study.

OBJECTIVES
This study sought to evaluate this transcatheter aortic valve (TAV) bioprosthesis in patients who are poorly suitable for surgical aortic valve (AV) replacement.


BACKGROUND
A novel self-expandable TAV bioprosthesis was designed to provide a low-profile delivery system, conformable annular sealing, and the ability to resheath and reposition during deployment.


METHODS
The Evolut R U.S. study included 241 patients with severe aortic stenosis who were deemed to be at least high risk for surgery treated at 23 clinical sites in the United States. Clinical outcomes at 30 days were evaluated using Valve Academic Research Consortium-2 criteria. An independent echocardiography laboratory was used to evaluate hemodynamic outcomes.


RESULTS
Patients were elderly (83.3 ± 7.2 years of age) and had high surgical risk (Society of Thoracic Surgeons predicted risk of mortality of 7.4 ± 3.4%). The majority of patients (89.5%) were treated by iliofemoral access. Resheathing or recapturing was performed in 22.6% of patients; more than 1 valve was required in 3 patients (1.3%). The 30-day outcomes included all-cause mortality (2.5%), disabling stroke (3.3%), major vascular complications (7.5%), life-threatening or disabling bleeding (7.1%), and new permanent pacemaker (16.4%). AV hemodynamics were markedly improved at 30 days: the mean AV gradient was reduced from 48.2 ± 13.0 mm Hg to 7.8 ± 3.1 mm Hg (p < 0.001) and AV area increased from 0.6 ± 0.2 cm2 to 1.9 ± 0.5 cm2 (p < 0.001). Moderate residual paravalvular leak was identified in 5.3% of patients.


CONCLUSIONS
We conclude that this novel self-expanding TAV bioprosthesis is safe and effective for the treatment of patients with severe aortic stenosis who are suboptimal for surgery. (Medtronic CoreValve Evolut R U.S. Clinical Study; NCT02207569).
User modeling with personas

User demographic and behavior data obtained from real user observation provide valuable information for designers. Yet, such information can be misinterpreted if presented as statistic figures. Personas are fictitious user representations created in order to embody behaviors and motivations that a group of real users might express, representing them during the project development process. This article describes the persona as being an effective tool to the users' descriptive model.
The vitamin E isoforms α-tocopherol and γ-tocopherol have opposite associations with spirometric parameters: the CARDIA study

BACKGROUND
Clinical studies of the associations of vitamin E with lung function have reported conflicting results. However, these reports primarily examine the α-tocopherol isoform of vitamin E and have not included the isoform γ-tocopherol which we recently demonstrated in vitro opposes the function of α-tocopherol. We previously demonstrated, in vitro and in animal studies, that the vitamin E isoform α-tocopherol protects, but the isoform γ-tocopherol promotes lung inflammation and airway hyperresponsiveness.


METHODS
To translate these findings to humans, we conducted analysis of 4526 adults in the Coronary Artery Risk Development in Young Adults (CARDIA) multi-center cohort with available spirometry and tocopherol data in blacks and whites. Spirometry was obtained at years 0, 5, 10, and 20 and serum tocopherol was from years 0, 7 and 15 of CARDIA.


RESULTS
In cross-sectional regression analysis at year 0, higher γ-tocopherol associated with lower FEV1 (p = 0.03 in blacks and p = 0.01 in all participants) and FVC (p = 0.01 in blacks, p = 0.05 in whites, and p = 0.005 in all participants), whereas higher α-tocopherol associated with higher FVC (p = 0.04 in blacks and whites and p = 0.01 in all participants). In the lowest quartile of α-tocopherol, higher γ-tocopherol associated with a lower FEV1 (p = 0.05 in blacks and p = 0.02 in all participants). In contrast, in the lowest quartile of γ-tocopherol, higher α-tocopherol associated with a higher FEV1 (p = 0.03) in blacks. Serum γ-tocopherol >10 μM was associated with a 175-545 ml lower FEV1 and FVC at ages 21-55 years.


CONCLUSION
Increasing serum concentrations of γ-tocopherol were associated with lower FEV1 or FVC, whereas increasing serum concentrations of α-tocopherol was associated with higher FEV1 or FVC. Based on the prevalence of serum γ-tocopherol >10 μM in adults in CARDIA and the adult U.S. population in the 2011 census, we expect that the lower FEV1 and FVC at these concentrations of serum γ-tocopherol occur in up to 4.5 million adults in the population.
Cognitive Strategies for the Visual Search of Hierarchical Computer Displays

This article investigates the cognitive strategies that people use to search computer displays. Several different visual layouts are examined: unlabeled layouts that contain multiple groups of items but no group headings, labeled layouts in which items are grouped and each group has a useful heading, and a target-only layout that contains just one item. A number of plausible strategies were proposed for each layout. Each strategy was programmed into the EPIC cognitive architecture, producing models that simulate the human visual-perceptual, oculomotor, and cognitive processing required for the task. The models generate search time predictions. For unlabeled layouts, the mean layout search times are predicted by a purely random search strategy, and the more detailed positional search times are predicted by a noisy systematic strategy. The labeled layout search times are predicted by a hierarchical strategy in which first the group labels are systematically searched, and then the contents of the target group. The target-only layout search times are predicted by a strategy in which the eyes move directly to the sudden appearance of the target. The models demonstrate that human visual search performance can be explained largely in terms of the cognitive strategy HUMAN–COMPUTER INTERACTION, 2004, Volume 19, pp. 183–223 Copyright © 2004, Lawrence Erlbaum Associates, Inc. Anthony Hornof is a computer scientist with interests in human–computer interaction, cognitive modeling, visual search, and eye tracking; he is an Assistant Professor in the Department of Computer and Information Science at the University of Oregon. that is used to coordinate the relevant perceptual and motor processes, a clear and useful visual hierarchy triggers a fundamentally different visual search strategy and effectively gives the user greater control over the visual navigation, and cognitive strategies will be an important component of a predictive visual search tool. The models provide insights pertaining to the visual-perceptual and oculomotor processes involved in visual search and contribute to the science base needed for predictive interface analysis. 184 HORNOF
Flavourings significantly affect inhalation toxicity of aerosol generated from electronic nicotine delivery systems (ENDS).

BACKGROUND
E-cigarettes or electronic nicotine delivery systems (ENDS) are designed to deliver nicotine-containing aerosol via inhalation. Little is known about the health effects of flavoured ENDS aerosol when inhaled.


METHODS
Aerosol from ENDS was generated using a smoking machine. Various types of ENDS devices or a tank system prefilled with liquids of different flavours, nicotine carrier, variable nicotine concentrations and with modified battery output voltage were tested. A convenience sample of commercial fluids with flavour names of tobacco, piña colada, menthol, coffee and strawberry were used. Flavouring chemicals were identified using gas chromatography/mass spectrometry. H292 human bronchial epithelial cells were directly exposed to 55 puffs of freshly generated ENDS aerosol, tobacco smoke or air (controls) using an air-liquid interface system and the Health Canada intense smoking protocol. The following in vitro toxicological effects were assessed: (1) cell viability, (2) metabolic activity and (3) release of inflammatory mediators (cytokines).


RESULTS
Exposure to ENDS aerosol resulted in decreased metabolic activity and cell viability and increased release of interleukin (IL)-1β, IL-6, IL-10, CXCL1, CXCL2 and CXCL10 compared to air controls. Cell viability and metabolic activity were more adversely affected by conventional cigarettes than most tested ENDS products. Product type, battery output voltage and flavours significantly affected toxicity of ENDS aerosol, with a strawberry-flavoured product being the most cytotoxic.


CONCLUSIONS
Our data suggest that characteristics of ENDS products, including flavours, may induce inhalation toxicity. Therefore, ENDS users should use the products with caution until more comprehensive studies are performed.
A Woman in the World of Engineering

This paper discusses the career of one woman in the world of engineering as a way of pointing out the problems that women encounter in engineering. The problems include hiring, salaries, promotion, management, travel, and attitudes of coworkers. The paper includes suggestions for engineering professors to help prepare women students for engineering.
Outcomes With Edoxaban Versus Warfarin in Patients With Previous Cerebrovascular Events: Findings From ENGAGE AF-TIMI 48 (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48).

BACKGROUND AND PURPOSE
Patients with atrial fibrillation and previous ischemic stroke (IS)/transient ischemic attack (TIA) are at high risk of recurrent cerebrovascular events despite anticoagulation. In this prespecified subgroup analysis, we compared warfarin with edoxaban in patients with versus without previous IS/TIA.


METHODS
ENGAGE AF-TIMI 48 (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48) was a double-blind trial of 21 105 patients with atrial fibrillation randomized to warfarin (international normalized ratio, 2.0-3.0; median time-in-therapeutic range, 68.4%) versus once-daily edoxaban (higher-dose edoxaban regimen [HDER], 60/30 mg; lower-dose edoxaban regimen, 30/15 mg) with 2.8-year median follow-up. Primary end points included all stroke/systemic embolic events (efficacy) and major bleeding (safety). Because only HDER is approved, we focused on the comparison of HDER versus warfarin.


RESULTS
Of 5973 (28.3%) patients with previous IS/TIA, 67% had CHADS2 (congestive heart failure, hypertension, age, diabetes, prior stroke/transient ischemic attack) >3 and 36% were ≥75 years. Compared with 15 132 without previous IS/TIA, patients with previous IS/TIA were at higher risk of both thromboembolism and bleeding (stroke/systemic embolic events 2.83% versus 1.42% per year; P<0.001; major bleeding 3.03% versus 2.64% per year; P<0.001; intracranial hemorrhage, 0.70% versus 0.40% per year; P<0.001). Among patients with previous IS/TIA, annualized intracranial hemorrhage rates were lower with HDER than with warfarin (0.62% versus 1.09%; absolute risk difference, 47 [8-85] per 10 000 patient-years; hazard ratio, 0.57; 95% confidence interval, 0.36-0.92; P=0.02). No treatment subgroup interactions were found for primary efficacy (P=0.86) or for intracranial hemorrhage (P=0.28).


CONCLUSIONS
Patients with atrial fibrillation with previous IS/TIA are at high risk of recurrent thromboembolism and bleeding. HDER is at least as effective and is safer than warfarin, regardless of the presence or the absence of previous IS or TIA.


CLINICAL TRIAL REGISTRATION
URL: http://www.clinicaltrials.gov. Unique identifier: NCT00781391.
Media-portrayed idealized images, body shame, and appearance anxiety.

OBJECTIVE
This study was designed to determine the effects of media-portrayed idealized images on young women's body shame and appearance anxiety, and to establish whether the effects depend on advertisement type and on participant self-objectification.


METHOD
Participants were 39 female university students. Twenty-four magazine advertisements comprised 12 body-related and 12 non-body-related products, one half of each with, and the other one half without, idealized images. Preexposure and post exposure body shame and appearance anxiety measures were recorded.


RESULTS
Appearance anxiety increased after viewing advertisements featuring idealized images. There was also a significant interaction between self-objectification level and idealized body (presence vs. absence). No differences emerged for body-related compared with non-body-related product advertisements. The only result for body shame was a main effect for time. Participants' body shame increased after exposure to idealized images, irrespective of advertisement type.


DISCUSSION
Although our findings reveal that media-portrayed idealized images detrimentally affect the body image of young women, they highlight the individual differences in vulnerability and the different effects for different components of body image. These results are discussed in terms of their implications for the prevention and early intervention of body image and dieting-related disorders. (
Hyporesponsiveness to PegIFNα2B plus ribavirin in patients with hepatitis C-related advanced fibrosis.

BACKGROUND & AIMS
The success of pegylated-interferon (PegIFN)/ribavirin (Rbv) therapy of chronic hepatitis C is compromised by liver fibrosis. Whether fibrosis equally affects the two PegIFNα-based therapies is unknown. To assess the response to the two PegIFN regimens in patients with different degree of liver fibrosis.


METHODS
A sub-analysis of the MIST study: 431 consecutive naïve patients randomly assigned, based on HCV genotype, to receive either (A) PegIFNα2a 180 μg/wk plus daily Rbv 800-1200 mg or (B) PegIFNα2b 1.5 μg/kg/week plus daily Rbv 800-1200 mg, were stratified according to Ishak staging (S) into mild (S0-S2) or moderate (S3, S4) fibrosis and cirrhosis (S5, S6).


RESULTS
In A the sustained virological response (SVR) rates were not significantly influenced by fibrosis stage (71% in S0-S2, 66% in S3, S4, 53% in S5, S6, p=0.12), compared to B where the SVR rates differed according to fibrosis stage (65%, 46%, and 38%, p=0.004, respectively). This was even more so in HCV-1/4 patients treated with PegIFNα2b where the SVR rates were twice as many in S0-S2 vs. S≥3 (44% vs. 22%, p=0.02), while in A the SVR rates were similar between the two fibrosis subgroups (S0-S2: 47% vs. S≥3: 48%, p=0.8). By logistic regression analysis genotype 1/4 and lack of rapid virological response were independent predictors of treatment failure in both treatment groups, while S≥3 fibrosis was associated to PegIFNα2b treatment failure, only (OR 2.83, 95% CI 1.4-5.68, p=0.004).


CONCLUSIONS
Liver fibrosis was an independent moderator of treatment outcome in patients receiving PegIFNα2b, not in those receiving PegIFNα2a.
Graphical presentation of diagnostic information

BACKGROUND
Graphical displays of results allow researchers to summarise and communicate the key findings of their study. Diagnostic information should be presented in an easily interpretable way, which conveys both test characteristics (diagnostic accuracy) and the potential for use in clinical practice (predictive value).


METHODS
We discuss the types of graphical display commonly encountered in primary diagnostic accuracy studies and systematic reviews of such studies, and systematically review the use of graphical displays in recent diagnostic primary studies and systematic reviews.


RESULTS
We identified 57 primary studies and 49 systematic reviews. Fifty-six percent of primary studies and 53% of systematic reviews used graphical displays to present results. Dot-plot or box-and- whisker plots were the most commonly used graph in primary studies and were included in 22 (39%) studies. ROC plots were the most common type of plot included in systematic reviews and were included in 22 (45%) reviews. One primary study and five systematic reviews included a probability-modifying plot.


CONCLUSION
Graphical displays are currently underused in primary diagnostic accuracy studies and systematic reviews of such studies. Diagnostic accuracy studies need to include multiple types of graphic in order to provide both a detailed overview of the results (diagnostic accuracy) and to communicate information that can be used to inform clinical practice (predictive value). Work is required to improve graphical displays, to better communicate the utility of a test in clinical practice and the implications of test results for individual patients.
Weak units and homotopy 3-types

We show that every braided monoidal category arises as End(I) for a weak unit I in an otherwise completely strict monoidal 2-category. This implies a version of Simpson’s weak-unit conjecture in dimension 3, namely that one-object 3-groupoids that are strict in all respects, except that the object has only weak identity arrows, can model all connected, simply connected homotopy 3-types. The proof has a clear intuitive content and relies on a geometrical argument with string diagrams and configuration spaces. 0. Introduction The subtleties and challenges of higher category theory start with the observation (in fact, not a trivial result) that not every weak 3-category is equivalent to a strict 3-category. The topological counterpart of this is that not every homotopy 3type can be realised by a strict 3-groupoid. The discrepancy between the strict and weak worlds can be pinpointed down to the case of connected, simply-connected 3-types, where it can be observed rather explicitly: such 3-types correspond to braided monoidal categories (in fact braided categorical groups), while connected, simply-connected strict 3-categories are essentially commutative monoidal categories — the braiding is forced to collapse, as a consequence of the Eckmann-Hilton argument. In precise terms, strict n-groupoids can realise only homotopy n-types with trivial Whitehead brackets. This collapse can be circumvented by weakening the structures. The notion of tricategory of Gordon, Power, and Street [1] is meant to be the weakest possible definition of 3-category. They show that a tricategory with only one object is equivalent to a Gray monoid, and in particular, a tricategory with one object and one arrow is equivalent to a braided monoidal category. Furthermore, every braided monoidal category arises in this way. The most general result relating higher categories to homotopy types is Tamsamani’s theorem [9], that weak n-groupoids (in 1991 Mathematics Subject Classification. 18D05; 18D10; 55P99.
An up to 16-year prospective study of 304 porcelain veneers.

PURPOSE
This study aimed to prospectively analyze the outcomes of 304 feldspathic porcelain veneers prepared by the same operator, in 100 patients, that were in situ for up to 16 years.


MATERIALS AND METHODS
A total of 304 porcelain veneers on incisors, canines, and premolars in 100 patients completed by one prosthodontist between 1988 and 2003 were sequentially included. Preparations were designed with chamfer margins, incisal reduction, and palatal overlap. At least 80% of each preparation was in enamel. Feldspathic porcelain veneers from refractory dies were etched (hydrofluoric acid), silanated, and cemented (Vision 2, Mirage Dental Systems). Outcomes were expressed as percentages (success, survival, unknown, dead, repair, failure). The results were statistically analyzed using the chi-square test and Kaplan-Meier survival estimation. Statistical significance was set at P < .05.


RESULTS
The cumulative survival for veneers was 96% +/- 1% at 5 to 6 years, 93% +/- 2% at 10 to 11 years, 91% +/- 3% at 12 to 13 years, and 73% +/- 16% at 15 to 16 years. The marked drop in survival between 13 and 16 years was the result of the death of 1 patient and the low number of veneers in that period. The cumulative survival was greater when different statistical methods were employed. Sixteen veneers in 14 patients failed. Failed veneers were associated with esthetics (31%), mechanical complications (31%), periodontal support (12.5%), loss of retention >2 (12.5%), caries (6%), and tooth fracture (6%). Statistically significantly fewer veneers survived as the time in situ increased.


CONCLUSIONS
Feldspathic porcelain veneers, when bonded to enamel substrate, offer a predictable long-term restoration with a low failure rate. The statistical methods used to calculate the cumulative survival can markedly affect the apparent outcome and thus should be clearly defined in outcome studies.