LLukas22/scidocs huggingface dataset:
Tandem dosing of samarium-153 ethylenediamine tetramethylene phosphoric acid with stem cell support for patients with high-risk osteosarcoma.

BACKGROUND
Samarium-153 ethylenediamine tetramethylene phosphoric acid (153Sm-EDTMP) is a radiopharmaceutical that has been used to treat osteosarcoma. The authors conducted a phase 2 study to test safety and response of high-risk osteosarcoma to tandem doses of 153Sm-EDTMP and to determine correlation between radiation delivered by low and high administered activities.


METHODS
Patients with recurrent, refractory osteosarcoma detectable on standard 99mTc bone scan received a low dose of 153Sm-EDTMP (37.0-51.8 MBq/kg), followed upon count recovery by a second, higher dose (222 MBq/kg). Fourteen days later, patients were rescued with autologous hematopoietic stem cells. The authors assessed response to therapy, performed dosimetry to determine the relationship between administered activity and tumor absorbed dose, and investigated whether changes in 2-(fluorine-18) fluoro-2-deoxy-d-glucose (18F-FDG) tumor uptake upon hematologic recovery reflected disease response.


RESULTS
Nine patients were given tandem doses of 153Sm-EDTMP; 2 received only the initial dose because of disease progression. Six patients experienced radiographic disease stabilization, but this was not considered a response, so the study was terminated early. There was a linear relationship between administered activity and tumor absorbed dose, but there was no correlation between change in 18F-FDG positron emission tomography tumor uptake and tumor absorbed dose or time to progression. The median time to progression for the entire group was 79 days.


CONCLUSIONS
Tandem doses of 153Sm-EDTMP were safe for this cohort of heavily pretreated patients with very high-risk disease. The strong correlation between absorbed dose and administered activity within each evaluable patient provides a methodology to individually tailor tandem doses of this agent.
Maritime Traffic Monitoring Based on Vessel Detection, Tracking, State Estimation, and Trajectory Prediction

Maneuvering vessel detection and tracking (VDT), incorporated with state estimation and trajectory prediction, are important tasks for vessel navigational systems (VNSs), as well as vessel traffic monitoring and information systems (VTMISs) to improve maritime safety and security in ocean navigation. Although conventional VNSs and VTMISs are equipped with maritime surveillance systems for the same purpose, intelligent capabilities for vessel detection, tracking, state estimation, and navigational trajectory prediction are underdeveloped. Therefore, the integration of intelligent features into VTMISs is proposed in this paper. The first part of this paper is focused on detecting and tracking of a multiple-vessel situation. An artificial neural network (ANN) is proposed as the mechanism for detecting and tracking multiple vessels. In the second part of this paper, vessel state estimation and navigational trajectory prediction of a single-vessel situation are considered. An extended Kalman filter (EKF) is proposed for the estimation of vessel states and further used for the prediction of vessel trajectories. Finally, the proposed VTMIS is simulated, and successful simulation results are presented in this paper.
A STUDY OF TRANSLATION ERROR RATE WITH TARGETED HUMAN ANNOTATION

We define a new, intuitive measure for evaluating machine translation output that avoids the knowledge intensiveness of more meaning-based approaches, and the labor-intensiveness of human judgments. Translation Error Rate (TER) measures the amount of editing that a human would have to perform to change a system output so it exactly matches a reference translation. We also compute a human-targeted TER (or HTER), where the minimum TER of the translation is computed against a human ‘targeted reference’ that preserves the meaning (provided by the reference translations) and is fluent, but is chosen to minimize the TER score for a particular system output. We show that: (1) The single-reference variant of TER correlates as well with human judgments of MT quality as the four-reference variant of BLEU; (2) The human-targeted HTER yields a 33% error-rate reduction and is shown to be very well correlated with human judgments; (3) The four-reference variant of TER and the single-reference variant of HTER yield higher correlations with human judgments than BLEU; (4) HTER yields higher correlations with human judgments than METEOR or its human-targeted variant (HMETEOR); and (5) The four-reference variant of TER correlates as well with a single human judgment as a second human judgment does, while HTER, HBLEU, and HMETEOR correlate significantly better with a human judgment than a second human judgment does. This work has been supported, in part, by BBNT contract number 9500006806. 1
A customized appliance for molar uprighting and space regaining.

Fig. 1 A. 25-year-old male patient with mesially tipped upper right second molar before treatment. B. After removal of lower left third molar. molar uprighting.6 Although early mechanics tended to cause molar extrusion or premolar intrusion, more recently developed springs can upright molars without these undesirable side effects.7,8 The need for simpler appliances to manage relatively limited adjunctive-orthodontic cases cannot be overemphasized. This article presents a quick and esthetic option for second-molar uprighting with a custom-designed space regainer. A orthodontic treatment is defined as tooth movement carried out to facilitate other dental procedures that may be required to control disease, restore function, or enhance appearance. As an example, an adult patient with a missing first molar is commonly treated by uprighting the adjacent second molar for eventual prosthetic replacement.1-5 Differential diagnosis, force selection, and appliance design are key factors in successful
Safety of sublingual-swallow immunotherapy in children aged 3 to 7 years.

BACKGROUND
The minimum age to start specific immunotherapy with inhalant allergens in children has not been clearly established, and position papers discourage its use in children younger than 5 years.


OBJECTIVE
To assess the safety of high-dose sublingual-swallow immunotherapy (SLIT) in a group of children younger than 5 years.


METHODS
Sixty-five children (51 boys and 14 girls; age range, 38-80 months; mean +/- SD age, 60 +/- 10 years; median age, 60 months) were included in this observational study. They were treated with SLIT with a build-up phase of 11 days, culminating in a top dose of 300 IR (index of reactivity) and a maintenance phase of 300 IR 3 times a week. The allergens used were house dust mites in 42 patients, grass pollen in 11 patients, olive pollen in 5 patients, Parietaria pollen in 4 patients, and cypress pollen in 3 patients. All adverse reactions and changes in the treatment schedule were compared in 2 subgroups: children 38 to 60 months old and children 61. to 80 months old.


RESULTS
The average cumulative dose of SLIT was 36,900 IR. Adverse reactions were observed in 11 children, none of them severe enough to require discontinuation of immunotherapy. Six reactions occurred in the 60 months or younger age group and 7 in the older than 60 months age group, with no differences between these 2 groups.


CONCLUSION
High-dose immunotherapy in children younger than 5 years does not cause more adverse reactions than in children aged 5 to 7 years. There is no reason to forbear studies on safety and efficacy of these preparations in young children.
HIGH MANEUVERING TARGET TRACKING USING A NOVEL HYBRID KALMAN FILTER-FUZZY LOGIC ARCHITECTURE

In this paper, a fast target maneuver detection technique and high accurate tracking scheme is proposed with the use of a new hybrid Kalman filter-fuzzy logic architecture. Due to the stressful environment of target tracking problem such as inaccurate detection and target maneuver, most of existing trackers do not represent desired performance in different situations. In practice, while the conventional Kalman filters (KF) perform well in tracking a target with constant velocity, their performance may be seriously degraded in the presence of maneuver. To reach an accurate target tracking system in such a stressful environment, fuzzy logic-based algorithms with intelligent adaptation capabilities have recently been issued. Although these methods yield reasonable performance in tracking maneuvering targets, their accuracy in non-maneuvering mode was not satisfactory. In this research, based on information about the target maneuver dynamics, a new hybrid tracker (HT) is introduced. The proposed algorithm combines two methodologies into one architecture synergistically. In other words, the KF is used when the target velocity is approximately constant, whereas fuzzy estimator is used when the target maneuvers. Simulation results show that the proposed method is superior to some conventional approaches in tracking accuracy.
Symbol Recognition: Current Advances and Perspectives

The recognition of symbols in graphic documents is an intensive research activity in the community of pattern recognition and document analysis. A key issue in the interpretation of maps, engineering drawings, diagrams, etc. is the recognition of domain dependent symbols according to a symbol database. In this work we first review the most outstanding symbol recognition methods from two different points of view: application domains and pattern recognition methods. In the second part of the paper, open and unaddressed problems involved in symbol recognition are described, analyzing their current state of art and discussing future research challenges. Thus, issues such as symbol representation, matching, segmentation, learning, scalability of recognition methods and performance evaluation are addressed in this work. Finally, we discuss the perspectives of symbol recognition concerning to new paradigms such as user interfaces in handheld computers or document database and WWW indexing by graphical content.
DDoS defense system for web services in a cloud environment

Recently, a new kind of vulnerability has surfaced: application layer Denial-of-Service (DoS) attacks targeting web services. These attacks aim at consuming resources by sending Simple Object Access Protocol (SOAP) requests that contain malicious XML content. These requests cannot be detected on the network or transportation (TCP/IP) layer, as they appear as legitimate packets. Until now, there is no web service security specification that addresses this problem. Moreover, the current WS-Security standard induces crucial additional vulnerabilities threatening the availability of certain web service implementations. First, this paper introduces an attack-generating tool to test and confirm previously reported vulnerabilities. The results indicate that the attacks have a devastating impact on theweb service availability, even whilst utilizing an absolute minimum of attack resources. Since these highly effective attacks can be mounted with relative ease, it is clear that defending against them is essential, looking at the growth of cloud andweb services. Second, this paper proposes an intelligent, fast and adaptive system for detecting against XML and HTTP application layer attacks. The intelligent system works by extracting several features and using them to construct a model for typical requests. Finally, outlier detection can be used to detect malicious requests. Furthermore, the intelligent defense system is capable of detecting spoofing and regular flooding attacks. The system is designed to be inserted in a cloud environmentwhere it can transparently protect the cloud broker and even cloud providers. For testing its effectiveness, the defense systemwas deployed to protect web services running onWSO2 with Axis2: the defacto standard for open source web service deployment. The proposed defense system demonstrates its capability to effectively filter out the malicious requests, whilst generating a minimal amount of overhead for the total response time. © 2014 Elsevier B.V. All rights reserved.
Comprehension Using Memory Networks

In this work, we will investigate the task of building a Question Answering system using deep neural networks augmented with a memory component. Our goal is to implement the MemNN and its extensions described in [10] and [8] and apply it on the bAbI QA tasks introduced in [9]. Unlike simulated datasets like bAbI, the vanilla MemNN system is not sufficient to achieve satisfactory performance on real-world QA datasets like Wiki QA [6] and MCTest [5]. We will explore extensions to the proposed MemNN systems to make it work on these complex datasets.
Reversibility of Fenofibrate Therapy–Induced Renal Function Impairment in ACCORD Type 2 Diabetic Participants

OBJECTIVE
To assess the reversibility of the elevation of serum creatinine levels in patients with diabetes after 5 years of continuous on-trial fenofibrate therapy.


RESEARCH DESIGN AND METHODS
An on-drug/off-drug ancillary study to the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Lipid Trial to investigate posttrial changes in serum creatinine and cystatin C. Eligible participants were recruited into a prospective, nested, three-group study based on retrospective on-trial serum creatinine levels: fenofibrate case subjects (n = 321, ≥ 20% increase after 3 months of therapy); fenofibrate control subjects (n = 175, ≤ 2% increase); and placebo control subjects (n = 565). Serum creatinine and cystatin C were measured at trial end and 6-8 weeks after discontinuation of trial therapy. RESULTS At trial end, case subjects had the highest adjusted serum creatinine (± SE) mg/dL (1.11 ± 0.02) and the lowest adjusted estimated glomerular filtration rate (eGFR) (± SE) mL/min/1.73 m(2) (68.4 ± 1.0) versus control subjects (1.01 ± 0.02; 74.8 ± 1.3) and placebo subjects (0.98 ± 0.01; 77.8 ± 0.7). After 51 days off-drug, serum creatinine in case subjects was still higher (0.97 ± 0.02) and eGFR still lower (77.8 ± 1.0) than control subjects (0.90 ± 0.02; 81.8 ± 1.3) but not different from placebo subjects (0.99 ± 0.01; 76.6 ± 0.7). Changes in serum cystatin C recapitulated the serum creatinine changes.


CONCLUSIONS
Participants with significant initial on-trial increases in serum creatinine (≥ 20%) returned to the same level of renal function as participants receiving placebo while participants who had ≤ 2% increase in serum creatinine had net preservation of renal function compared with the same unselected placebo reference group. The fenofibrate-associated on-trial increases in serum creatinine were reversible, and the reversal was complete after 51 days off-drug. The similarity of the cystatin C results suggests that the mechanism of this change is not specific for serum creatinine.
The unitary-model-operator approach to nuclear many-body problems

Microscopic nuclear structure calculations have been performed within the framework of the unitary-model-operator approach. Ground-state and single-particle energies are calculated for nuclei around 14C, 16O and 40Ca with modern nucleon–nucleon interactions.
Web Video Popularity Prediction using Sentiment and Content Visual Features

Hundreds of hours of videos are uploaded every minute on YouTube and other video sharing sites: some will be viewed by millions of people and other will go unnoticed by all but the uploader. In this paper we propose to use visual sentiment and content features to predict the popularity of web videos. The proposed approach outperforms current state-of-the-art methods on two publicly available datasets.
Modified two-stage procedures for the treatment of gingival recession.

BACKGROUND
Unfavorable conditions at the soft tissues adjacent to a recession defect may preclude performing pedicle flaps (advanced or rotational) both as a root coverage procedure, and as a covering flap for a connective tissue graft. Free gingival grafts may not be recommended because of the low root coverage predictability and the poor esthetic outcome. The goal of the present case report is to suggest modifications of the two-stage surgical technique aimed at improving root coverage and esthetic outcomes, and reducing patient morbidity.


METHOD
In the first case report, a Miller class II gingival recession, associated with a deep buccal probing depth, affecting a lower central incisor was treated. In the first step of the surgery an epithelized graft with an apical-coronal dimension equal to the keratinized tissue height of the adjacent teeth was sutured apical to the bone dehiscence. Four months later, a coronally advanced flap was performed to cover the root exposure. In the second case report, a Miller class III gingival recession, complicated with a deep buccal probing depth affecting the mesial root of the first lower molar was treated. In the first step of the surgery, a free gingival graft was positioned mesially to the root exposure to create keratinized tissue lateral to the recession defect. This was adequate to perform the laterally moved, coronally advanced flap that was used as a second-step root coverage surgical procedure.


RESULTS
In the first case report complete root coverage, an increase (4 mm) in keratinized tissue height and realignment of the mucogingival line were achieved 1 year after the surgery. The reduced dimension of the graft permitted to minimize patient's discomfort and to obtain good esthetics of mucogingival tissues. These successful outcomes were well maintained for 5 years. In the second case report successful root coverage, increase (3 mm) in keratinized tissue height and good harmony of mucogingival tissues were achieved 1 year after the surgery. These outcomes were well maintained 5 years after the surgery.


CONCLUSIONS
The present study suggested that modifications of the two-stage procedure by minimizing the dimension of the graft and by standardizing the surgical techniques allowed successful results to be achieved in the treatment of gingival recessions characterized by local conditions that otherwise preclude the use of one-step root coverage surgical techniques.
Exquisite Sensitivity of TP53 Mutant and Basal Breast Cancers to a Dose-Dense Epirubicin−Cyclophosphamide Regimen

BACKGROUND
In breast cancers, only a minority of patients fully benefit from the different chemotherapy regimens currently in use. Identification of markers that could predict the response to a particular regimen would thus be critically important for patient care. In cell lines or animal models, tumor protein p53 (TP53) plays a critical role in modulating the response to genotoxic drugs. TP53 is activated in response to DNA damage and triggers either apoptosis or cell-cycle arrest, which have opposite effects on cell fate. Yet, studies linking TP53 status and chemotherapy response have so far failed to unambiguously establish this paradigm in patients. Breast cancers with a TP53 mutation were repeatedly shown to have a poor outcome, but whether this reflects poor response to treatment or greater intrinsic aggressiveness of the tumor is unknown.


METHODS AND FINDINGS
In this study we analyzed 80 noninflammatory breast cancers treated by frontline (neoadjuvant) chemotherapy. Tumor diagnoses were performed on pretreatment biopsies, and the patients then received six cycles of a dose-dense regimen of 75 mg/m(2) epirubicin and 1,200 mg/m(2) cyclophosphamide, given every 14 days. After completion of chemotherapy, all patients underwent mastectomies, thus allowing for a reliable assessment of chemotherapy response. The pretreatment biopsy samples were used to determine the TP53 status through a highly efficient yeast functional assay and to perform RNA profiling. All 15 complete responses occurred among the 28 TP53-mutant tumors. Furthermore, among the TP53-mutant tumors, nine out of ten of the highly aggressive basal subtypes (defined by basal cytokeratin [KRT] immunohistochemical staining) experienced complete pathological responses, and only TP53 status and basal subtype were independent predictors of a complete response. Expression analysis identified many mutant TP53-associated genes, including CDC20, TTK, CDKN2A, and the stem cell gene PROM1, but failed to identify a transcriptional profile associated with complete responses among TP53 mutant tumors. In patients with unresponsive tumors, mutant TP53 status predicted significantly shorter overall survival. The 15 patients with responsive TP53-mutant tumors, however, had a favorable outcome, suggesting that this chemotherapy regimen can overcome the poor prognosis generally associated with mutant TP53 status.


CONCLUSIONS
This study demonstrates that, in noninflammatory breast cancers, TP53 status is a key predictive factor for response to this dose-dense epirubicin-cyclophosphamide regimen and further suggests that the basal subtype is exquisitely sensitive to this association. Given the well-established predictive value of complete responses for long-term survival and the poor prognosis of basal and TP53-mutant tumors treated with other regimens, this chemotherapy could be particularly suited for breast cancer patients with a mutant TP53, particularly those with basal features.
Adjustable speed generators for wind turbines based on doubly-fed induction machines and 4-quadrant IGBT converters linked to the rotor

Wind turbines are being built at power levels above 1.5 MW. Higher power levels are being anticipated for off-shore applications. To limit mechanical stresses and power surges in these high power systems speed control is necessary. The doubly-fed induction generator (DFIG) system is investigated as a viable alternative to adjust speed over a wide range while keeping cost of the power converters minimal. A four-quadrant IGBT ac-to-ac converter is used to feed power bi-directionally to the rotor circuit. Decoupled control of active and reactive power can be realized using the dynamic model of the DFIG. Simulations and measurements confirm the validity of the model and the viability of the DFIG wind turbine.
Evaluation of the Shear Strength of Dapped Ended Beam

Dapped end beams are precast members of concrete structures which are widely used in buildings and bridges. The re-entrant corner is the weakest portion of the beam, where stress concentration develops, such regions are known as disturbed regions. These regions cannot be analyzed with ordinary flexural analysis theory rather than another method named Strut and Tie Model (STM) is used. The same approach has been used in this research. In this research four reinforced concrete dapped end beams divided into two groups G-1 and G-2 having depths of 18” (457 mm) and 12” (305 mm) respectively were designed for the assumed external load. The beams were later tested under monotonic loads to study the shear strength of the dapped ends and compared with the assumed external designed loads. In case of G-1, failure loads were observed much higher than the design loads, which show that STM gives very conservative solution for the design of dapped ended beams of greater depth. Actual values of strut forces have been observed as quite closer to the values proposed by ACI 318-08 for both diagonal bottled shaped struts and horizontal prismatic struts. The experimental values of strength reduction factor for struts βs are also close to the values specified in ACI code. Whereas, in case of beams of G-2, failure loads were observed lower than the design loads, which shows that STM gives non realistic solution for the design of dapped end beams of lower depth. Actual values of strut forces and strength reduction factor βs are also very smaller as compared to the values proposed by ACI code. [Ahmad S, Elahi A, Hafeez J. Evaluation of the Shear Strength of Dapped Ended Beam. Life Sci J 2013;10(3):1038-1044] (ISSN:1097-8135). http://www.lifesciencesite.com. 151