LLukas22/scidocs huggingface dataset:
Multicenter pilot treatment trial for psychogenic nonepileptic seizures: a randomized clinical trial.

IMPORTANCE
There is a paucity of controlled treatment trials for the treatment of conversion disorder, seizures type, also known as psychogenic nonepileptic seizures (PNES). Psychogenic nonepileptic seizures, the most common conversion disorder, are as disabling as epilepsy and are not adequately addressed or treated by mental health clinicians.


OBJECTIVE
To evaluate different PNES treatments compared with standard medical care (treatment as usual).


DESIGN, SETTING, AND PARTICIPANTS
Pilot randomized clinical trial at 3 academic medical centers with mental health clinicians trained to administer psychotherapy or psychopharmacology to outpatients with PNES. Thirty-eight participants were randomized in a blocked schedule among 3 sites to 1 of 4 treatment arms and were followed up for 16 weeks between September 2008 and February 2012; 34 were included in the analysis.


INTERVENTIONS
Medication (flexible-dose sertraline hydrochloride) only, cognitive behavioral therapy informed psychotherapy (CBT-ip) only, CBT-ip with medication (sertraline), or treatment as usual.


MAIN OUTCOMES AND MEASURES
Seizure frequency was the primary outcome; psychosocial and functioning measures, including psychiatric symptoms, social interactions, quality of life, and global functioning, were secondary outcomes. Data were collected prospectively, weekly, and with baseline, week 2, midpoint (week 8), and exit (week 16) batteries. Within-group analyses for each arm were performed on primary (seizure frequency) and secondary outcomes from treatment-blinded raters using an intention-to-treat analysis.


RESULTS
The psychotherapy (CBT-ip) arm showed a 51.4% seizure reduction (P = .01) and significant improvement from baseline in secondary measures including depression, anxiety, quality of life, and global functioning (P < .001). The combined arm (CBT-ip with sertraline) showed 59.3% seizure reduction (P = .008) and significant improvements in some secondary measures, including global functioning (P = .007). The sertraline-only arm did not show a reduction in seizures (P = .08). The treatment as usual group showed no significant seizure reduction or improvement in secondary outcome measures (P = .19).


CONCLUSIONS AND RELEVANCE
This pilot randomized clinical trial for PNES revealed significant seizure reduction and improved comorbid symptoms and global functioning with CBT-ip for PNES without and with sertraline. There were no improvements in the sertraline-only or treatment-as-usual arms. This study supports the use of manualized psychotherapy for PNES and successful training of mental health clinicians in the treatment. Future studies could assess larger-scale intervention dissemination.


TRIAL REGISTRATION
clinicaltrials.gov Identifier: NCT00835627.
Effect of Fruit Juice on Glucose Control and Insulin Sensitivity in Adults: A Meta-Analysis of 12 Randomized Controlled Trials

BACKGROUND
Diabetes mellitus has become a worldwide health problem. Whether fruit juice is beneficial in glycemic control is still inconclusive. This study aimed to synthesize evidence from randomized controlled trials on fruit juice in relationship to glucose control and insulin sensitivity.


METHODS
A strategic literature search of PubMed, EMBASE, and the Cochrane Library (updated to March, 2014) was performed to retrieve the randomized controlled trials that evaluated the effects of fruit juice on glucose control and insulin sensitivity. Study quality was assessed using the Jadad scale. Weighted mean differences were calculated for net changes in the levels of fasting glucose, fasting insulin, hemoglobin A1c (HbA1c), and homeostatic model assessment of insulin resistance (HOMA-IR) using fixed- or random-effects model. Prespecified subgroup and sensitivity analyses were performed to explore the potential heterogeneity.


RESULTS
Twelve trials comprising a total of 412 subjects were included in the current meta-analysis. The numbers of these studies that reported the data on fasting glucose, fasting insulin, HbA1c and HOMA-IR were 12, 5, 3 and 3, respectively. Fruit juice consumption did not show a significant effect on fasting glucose and insulin concentrations. The net change was 0.79 mg/dL (95% CI: -1.44, 3.02 mg/dL; P = 0.49) for fasting glucose concentrations and -0.74 µIU/ml (95% CI: -2.62, 1.14 µIU/ml; P = 0.44) for fasting insulin concentrations in the fixed-effects model. Subgroup analyses further suggested that the effect of fruit juice on fasting glucose concentrations was not influenced by population region, baseline glucose concentration, duration, type of fruit juice, glycemic index of fruit juice, fruit juice nutrient constitution, total polyphenols dose and Jadad score.


CONCLUSION
This meta-analysis showed that fruit juice may have no overall effect on fasting glucose and insulin concentrations. More RCTs are warranted to further clarify the association between fruit juice and glycemic control.
Evaluation of docetaxel plus estramustine in the treatment of patients with hormone-refractory prostate cancer.

OBJECTIVES
To investigate the feasibility and efficacy of docetaxel-based chemotherapy in patients with hormone-refractory prostate cancer (HRPC).


METHODS
Forty-six consecutive HRPC patients treated between January 2003 and March 2008 were included in this analysis. Docetaxel was given at a dose of 35 mg/m(2) twice every 3 weeks and oral estramustine concurrently for three consecutive days during weeks 1 and 2 of each cycle. During each treatment week, the dose of estramustine was 1260 mg on the first day, 980 mg on the second day and 840 mg on the third day. Patients were premedicated with 4 mg twice a day of oral dexamethasone for three consecutive days. Treatment was continued until evidence of disease progression or unacceptable toxicity. Prostate-specific antigen (PSA) levels were evaluated at least once every 4 weeks.


RESULTS
Patients received a median of three cycles of chemotherapy. Of the evaluable 46 patients, 25 (54%) had a >or=50% PSA decline and 12 (26%) had a >or=75% PSA decline. Median time to PSA progression and overall survival time were 10.1 and 27.0 months, respectively. Median follow-up was 15.0 months. Major severe toxicities were grade 3 or 4 leukopenia in five (11%) patients. Mild toxicities included grade 1 or 2 nausea in eight (17%) patients. Two patients could not continue the treatment because of interstitial pneumonitis and a gastric hemorrhage, respectively.


CONCLUSIONS
Docetaxel plus estramustine chemotherapy represents an active and well tolerated treatment for Japanese HRPC patients.
Conjugated equine estrogens and colorectal cancer incidence and survival: the Women's Health Initiative randomized clinical trial.

BACKGROUND
In separate Women's Health Initiative randomized trials, combined hormone therapy with estrogen plus progestin reduced colorectal cancer incidence but estrogen alone in women with hysterectomy did not. We now analyze features of the colorectal cancers that developed and examine the survival of women following colorectal cancer diagnosis in the latter trial.


PARTICIPANTS AND METHODS
10,739 postmenopausal women who were 50 to 79 years of age and had undergone hysterectomy were randomized to conjugated equine estrogens (0.625 mg/d) or matching placebo. Colorectal cancer incidence was a component of the monitoring global index of the study but was not a primary study endpoint. Colorectal cancers were verified by central medical record and pathology report review. Bowel exam frequency was not protocol defined, but information on their use was collected.


RESULTS
After a median 7.1 years, there were 58 invasive colorectal cancers in the hormone group and 53 in the placebo group [hazard ratio, 1.12; 95% confidence interval (95% CI), 0.77-1.63]. Tumor size, stage, and grade were comparable in the two randomization groups. Bowel exam frequency was also comparable in the two groups. The cumulative mortality following colorectal cancer diagnosis among women in the conjugated equine estrogen group was 34% compared with 30% in the placebo group (hazard ratio, 1.34; 95% CI, 0.58-3.19).


CONCLUSIONS
In contrast to the preponderance of observational studies, conjugated equine estrogens in a randomized clinical trial did not reduce colorectal cancer incidence nor improve survival after diagnosis.
History of anthropogenically mediated eutrophication of Lake Peipsi as revealed by the stratigraphy of fossil pigments and molecular size fractions of pore-water dissolved organic matter

We investigated stratigraphic changes in fossil pigments and the molecular structure of the UV-absorbing fraction of pore-water dissolved organic matter in a sedimentary record from Lake Peipsi (Estonia/Russia) temporally covering the 20th century. The aims of the study were to define the onset of eutrophication in the lake and to track its course. An attempt was also made to reconstruct lake conditions before the intensive nutrient loading began. Fossil pigment analysis indicated that the eutrophication of the lake started in the 1960s and accelerated in the 1970s. Sedimentary pigments also indicate a continuing tendency of the lake ecosystem towards eutrophy in the 1980s and 1990s. However, changes in the molecular size structure of pore-water dissolved organic matter indicated that the contribution of autochthonous matter to the organic pool of the lake ecosystem had already started to increase around the end of the 1930s. We conclude that this rise was generated by a coincidence of several anthropogenic and natural factors. The pore-water data also show that a slight relative reduction in the autochthonous organic matter took place in the 1990s. A discordance in the paleodata obtained for the beginning of the 20th century complicates clear conclusions about earlier conditions in the lake. On the one hand, the qualitative characteristics of pore-water dissolved organic matter and the low concentration of chlorophyll a indicate that the phytoplankton biomass was low in Lake Peipsi during that period. On the other hand, the concentrations of marker pigments of specific phytoplankton groups are high, comparable with the values in the recent sediments. Possible reasons for the high levels of these pigments in the early 1900s sediments, such as a shift in the preservation conditions of organic substances and their transport from the lake’s catchment, are discussed.
Hot-carrier reliability in submicrometer 40V LDMOS transistors with thick gate oxide

The hot-carrier reliability in thick gate oxide LDMOS transistors is presented for the first time and two distinct behaviors are found. First, higher V/sub gs/ stressing results in a greater degradation because of the Kirk effect. Second, AC lifetime is much longer than DC lifetime because of the recovery in degradation.
Magnetics for neutral current compensation in three-phase four-wire distribution system

In this paper, a number of methods for neutral current compensation using magnetics are proposed and these are compared with reported techniques. The proposed neutral current mitigation techniques include a Scott-transformer, T-connected transformer, star-hexagon transformer and starpolygon transformer designed for mmf (magneto motive force) balance. These transformer configurations along with the conventional transformer configurations such as a star-delta transformer and a zig-zag transformer are analysed, designed, simulated and verified by developing prototypes. The transformers provide a path to the zero sequence fundamental as well as harmonics currents. Two single phase transformers are required for the proposed Scott-connection and T-connection where as three single phase transformers are required in other methods. The neutral current compensation schemes using transformers are modeled and simulated using MATLAB with its Simpower systems (SPS) toolboxes and compared to demonstrate the effectiveness of the proposed transformers. Laboratory prototypes of the transformers are developed and their test results are presented to validate the design of transformers for neutral current compensation.
Music score alignment and computer accompaniment

By relating musical sound to musical notation, these systems generate tireless, expressive musical accompaniment to follow and sometimes learn from a live human performance.
From past to future: Temporal self-continuity across the life span.

Although perceived continuity with one's future self has attracted increasing research interest, age differences in this phenomenon remain poorly understood. The present study is the first to simultaneously examine past and future self-continuity across multiple temporal distances using both explicit and implicit measures and controlling for a range of theoretically implicated covariates in an adult life span sample (N = 91, aged 18-92, M = 50.15, SD = 19.20, 56% female). Perceived similarity to one's self across 6 past and 6 future time points (1 month to 10 years) was assessed with an explicit self-report measure and an implicit me/not me trait rating task. In multilevel analyses, age was significantly associated with greater implicit and explicit self-continuity, especially for more distant intervals. Further, reaction times (RTs) in the implicit task remained stable with temporal distance for older adults but decreased with temporal distance for younger adults, especially for future ratings. This points toward age differences in the underlying mechanisms of self-continuity. Multilevel models examined the role of various covariates including personality, cognition, future horizons, and subjective health and found that none of them could fully account for the observed age effects. Taken together, our findings suggest that chronological age is associated with greater self-continuity although specific mechanisms and correlates may vary by age. (PsycINFO Database Record
The behaviour of the LSPMSM in asynchronous operation

The paper proposes a study of synchronization capability of line-start permanent magnet synchronous motor with small saliency ratio and very high cage resistance. The exemplified method is for a motor with the rated power of 3.5 kW, the synchronous speed of 3000 rpm, and the saliency ratio of 1.08.
Elements of Climate Evolution in yhe Area Between Prut and Dniester Rivers. Landscape and Pedogenetic Implications

Component part of the Carpathian-Danubian-Pontic space, the interfluve area between Prut and Dniester is subject to the regional process of climate evolution and change. In what regards the concept of human-influenced pedogenesis, the role of the biological factor is significantly reduced. As a consequence the direction and intensity of the elementary landscape and pedogenetic processes are determined by the relations between climate and the geomorphological factor. In the conditions of a relative stability of the geomorphological factor, the determining role is held by climate. To this is added soil vulnerability to the implications of climate changes, determined by the degree of soil physical degradation but also by a series of intrinsic and external (drainage) factors. This implies the idea of the control and management of the landscape and pedogenetic implications of climate changes by improving soil physical characteristics. Introduction In diverse forms and with different intensity, climate changes are felt by all world countries. Their impact represents combinations of slow changes (temperature or ecosystem changes) and sudden manifestations (extreme rainfall quantities, floods). In the socio-economical area, climate changes are manifested in the intensification of the stress states, cataclysms and the considerable increase of expenses to cover material losses and repairing infrastructure. In the Carpathian-Danubian-Pontic area climate changes imply: changes in the temperature regime (extreme temperatures in the warm period); changes in the State University of Moldova 2 Prof. PhD. “Alexandru Ioan Cuza” University of Iaşi, Romania Gheorghe Jigău, Liviu Apostol, Ana Barsan, Elena Tofan 112 precipitation regime (increases of the extreme quantities); an increase in the frequency and intensity of drought periods; intensification of desertification effect. In what follows we present a first evaluation of the implications of climate changes on the direction and intensity of elementary landscape and pedogenetic processes.
Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex.

OBJECTIVE
Studies of the neurobiological processes underlying drug addiction primarily have focused on limbic subcortical structures. Here the authors evaluated the role of frontal cortical structures in drug addiction.


METHOD
An integrated model of drug addiction that encompasses intoxication, bingeing, withdrawal, and craving is proposed. This model and findings from neuroimaging studies on the behavioral, cognitive, and emotional processes that are at the core of drug addiction were used to analyze the involvement of frontal structures in drug addiction.


RESULTS
The orbitofrontal cortex and the anterior cingulate gyrus, which are regions neuroanatomically connected with limbic structures, are the frontal cortical areas most frequently implicated in drug addiction. They are activated in addicted subjects during intoxication, craving, and bingeing, and they are deactivated during withdrawal. These regions are also involved in higher-order cognitive and motivational functions, such as the ability to track, update, and modulate the salience of a reinforcer as a function of context and expectation and the ability to control and inhibit prepotent responses.


CONCLUSIONS
These results imply that addiction connotes cortically regulated cognitive and emotional processes, which result in the overvaluing of drug reinforcers, the undervaluing of alternative reinforcers, and deficits in inhibitory control for drug responses. These changes in addiction, which the authors call I-RISA (impaired response inhibition and salience attribution), expand the traditional concepts of drug dependence that emphasize limbic-regulated responses to pleasure and reward.
Measuring male-female relationships during the mating season in wild Japanese macaques (Macaca fuscata yakui)

Heterosexual relationships during one mating season were examined in a wild troop of Japanese macaques (Macaca fuscata yakui) on Yakushima Island, Japan. Validation tests of putative mate choice behaviors demonstrated that female initiation and maintenance of proximity, female lookback at the male, and sexual presents to the male, were associated with increased mating. Male grooming the female was also associated with increased mating. Ten dyadic social behaviors were subject to principal components analysis to empirically define behavioral dimensions of male-female relationships. The analysis yielded four relationship dimensions: ‘Mutual Choice and Male Coercion,’ ‘Female Choice’ (two types), and ‘Mutual Choice’ Dyads tended to be characterized by more than one dimension. The results suggested that females sought matings with multiple males of various dominance ranks. Female relationships with high ranking males contained elements of male coercion and mate guarding, however, because these males attempted to inhibit females from mating with lower ranking males. The correlation between each relationship dimension and mating success depended, in part, on the dominance rank of males. Relationships involving high ranking males, which were most likely to contain elements of male coercion and mate guarding, were associated with mating success. Relationships involving low ranking males, which usually lacked such coercive elements. were less strongly correlated with mating success. These results, obtained from a wild troop, are compared to those previously obtained in captive and provisioned groups of Japanese macaques.
The vestibular system: a spatial reference for bodily self-consciousness

Self-consciousness is the remarkable human experience of being a subject: the "I". Self-consciousness is typically bound to a body, and particularly to the spatial dimensions of the body, as well as to its location and displacement in the gravitational field. Because the vestibular system encodes head position and movement in three-dimensional space, vestibular cortical processing likely contributes to spatial aspects of bodily self-consciousness. We review here recent data showing vestibular effects on first-person perspective (the feeling from where "I" experience the world) and self-location (the feeling where "I" am located in space). We compare these findings to data showing vestibular effects on mental spatial transformation, self-motion perception, and body representation showing vestibular contributions to various spatial representations of the body with respect to the external world. Finally, we discuss the role for four posterior brain regions that process vestibular and other multisensory signals to encode spatial aspects of bodily self-consciousness: temporoparietal junction, parietoinsular vestibular cortex, ventral intraparietal region, and medial superior temporal region. We propose that vestibular processing in these cortical regions is critical in linking multisensory signals from the body (personal and peripersonal space) with external (extrapersonal) space. Therefore, the vestibular system plays a critical role for neural representations of spatial aspects of bodily self-consciousness.
Emotion recognition using a hierarchical binary decision tree approach

Automated emotion state tracking is a crucial element in the computational study of human communication behaviors. It is important to design robust and reliable emotion recognition systems that are suitable for real-world applications both to enhance analytical abilities to support human decision making and to design human–machine interfaces that facilitate efficient communication. We introduce a hierarchical computational structure to recognize emotions. The proposed structure maps an input speech utterance into one of the multiple emotion classes through subsequent layers of binary classifications. The key idea is that the levels in the tree are designed to solve the easiest classification tasks first, allowing us to mitigate error propagation. We evaluated the classification framework on two different emotional databases using acoustic features, the AIBO database and the USC IEMOCAP database. In the case of the AIBO database, we obtain a balanced recall on each of the individual emotion classes using this hierarchical structure. The performance measure of the average unweighted recall on the evaluation data set improves by 3.37% absolute (8.82% relative) over a Support Vector Machine baseline model. In the USC IEMOCAP database, we obtain an absolute improvement of 7.44% (14.58%) over a baseline Support Vector Machine modeling. The results demonstrate that the presented hierarchical approach is effective for classifying emotional utterances in multiple database contexts. 2011 Elsevier B.V. All rights reserved.