LLukas22/scidocs huggingface dataset:
Effect of simulated dawn on quality of sleep – a community-based trial

BACKGROUND
Morning light exposure administered as simulated dawn looks a promising method to treat Seasonal Affective Disorder, but it may moreover help with resetting the inaccurate organisation of body clock functions relative to sleep occurring in winter among people in general. Disturbances in sleep patterns are common and may compromise wellbeing even in the short term. Our hypothesis was that simulated dawn could improve the subjective quality of sleep during winter.


METHODS
A community-based trial with 100 volunteer subjects provided with dawn simulators. Study period lasted for eight weeks, and subjects used the dawn simulators for two weeks at a time, each subject acting as his own control (ABAB-design). Main outcome measure was subjective quality of sleep recorded each morning with Groningen Sleep Quality Scale.


RESULTS
77 subjects completed the trial. Quality of sleep improved while subjects were using dawn simulator-devices (p = 0.001). The treatment became beneficial after six days' use of dawn simulator, but the effect did not last after the use was ceased.


CONCLUSION
Dawn simulation may help to improve the subjective quality of sleep, but the benefits are modest. Further research is needed to verify these findings and to elucidate the mechanism by which dawn simulation acts on the sleep-wake pattern.
Zigbee-Based Smart Ordering System (S.O.S)

In the era of information technology, human tend to develop better and more convenient lifestyle. Nowadays, almost all the electronic devices are equipped with wireless technology. A wireless communication network has numerous advantages and becomes an important application. The enhancements provide by the wireless technology gives the ease of control to the users and not least the mobility of the devices within the network. It is use the Zigbee as the wireless modules. The Smart Ordering System introduced current and fast way to order food at a restaurant. The system uses a small keypad to place orders and the order made by inserting the code on the keypad menu. This code comes along with the menu. The signal will be delivered to the order by the Zigbee technology, and it will automatically be displayed on the screen in the kitchen. Keywords— smart, ordering, S.O.S, Zigbee.
Single administration of low dose cyclophosphamide augments the antitumor effect of dendritic cell vaccine

Single administration of low dose cyclophosphamide (CTX) was previously reported to enhance the antitumor efficacy of immunotherapies. To investigate the possible mechanisms for this effect, we examined whether a single administration of low dose CTX could augment the immunogenicity of dendritic cell (DC) vaccines. Fifty milligrams per kilogram body weight dose of CTX was administrated intraperitoneally to mice after B16 melanoma or C26 colon carcinoma tumor models were established, DC vaccine generated from mouse bone marrow and pulsed with B16 or C26 tumor cells lysates were vaccinated 4 days later. CTX treatment potentiated the antitumor effects of the DC vaccine, and increased the proportion of IFN-γ secreting lymphocytes in spleens. Furthermore, a significantly reduced proportion of CD4+CD25+FoxP3+ regulatory T (Treg) cells was detected by flow cytometry in spleen lymphocytes from tumor-bearing mice treated with CTX. Thus, a single administration of low dose CTX could augment antitumor immune responses of DC vaccine by reducing the proportion of CD4+CD25+FoxP3+ Treg cells in tumor-bearing mice. Our results suggested a possible mechanism of CTX-induced immunopotentiation and provided a strategy of immunotherapy combining a low dose CTX with DC vaccine.
Fuzzy group decision making for selection among computer integrated manufacturing systems

A decision to invest in new manufacturing enabling technologies supporting computer integrated manufacturing (CIM) must include non-quantifiable, intangible benefits to the organization in meeting its strategic goals. Therefore, use of tactical level, purely economic, evaluation methods normally result in the rejection of strategically vital automation proposals. This paper includes four different fuzzy multi-attribute group decision-making methods. The first one is a fuzzy model of group decision proposed by Blin. The second is fuzzy synthetic evaluation, the third is Yager’s weighted goals method, and the last one is fuzzy analytic hierarchy process. These methods are extended to select the best computer integrated manufacturing system by taking into account both intangible and tangible factors. A computer software for these approaches is developed and finally some numerical applications of these methods are given to compare the results of all methods. # 2003 Elsevier Science B.V. All rights reserved.
Effects of watermelon supplementation on aortic hemodynamic responses to the cold pressor test in obese hypertensive adults.

BACKGROUND
Cold-induced increases in aortic blood pressure (BP) may cause adverse cardiac events in hypertensives by increasing ventricular afterload. L-citrulline supplementation reduces BP at baseline and during the cold pressor test (CPT), but the effect on wave reflection (augmentation pressure (AP) and index (AIx)) is controversial. Our aim was to assess the effect of L-citrulline-rich watermelon supplementation on aortic hemodynamic responses to CPT in hypertensive adults.


METHODS
Brachial systolic BP (bSBP) and aortic systolic BP (aSBP), AP, AIx, AIx adjusted to 75 beats/min (AIx75), reflection time (Tr), first (P1) and second systolic peak (P2; wave reflection magnitude), heart rate (HR), and systolic time index (STI; myocardial oxygen demand) at baseline and during CPT and magnitude of the response from baseline to CPT were evaluated in 13 individuals (10 women; 57±1 year; bSBP 151±5 mm Hg). Participants were randomized to a 6-week watermelon or placebo supplementation in a crossover design.


RESULTS
Watermelon reduced (P < 0.05) bSBP, aSBP, P1, and P2 at baseline and CPT compared with placebo; thus, increases from baseline to CPT were unaffected. Watermelon did not affect AP, AIx, AIx75, and STI at baseline but decreased (P < 0.05) AP and STI during CPT and the increases in AP (~5mm Hg) and AIx75 (~7.3%) from baseline to CPT.


CONCLUSIONS
Watermelon supplementation reduced aortic BP and myocardial oxygen demand during CPT and the magnitude of the cold-induced increase in wave reflection in obese adults with hypertension. Watermelon may provide cardioprotection by attenuating cold-induced aortic hemodynamic responses.


CLINICAL TRIALS REGISTRATION
Clinicaltrial.gov register, NCT01185041.
Transmantle sign in focal cortical dysplasia: a unique radiological entity with excellent prognosis for seizure control.

OBJECT
Focal cortical dysplasia (FCD) represents a spectrum of developmental cortical abnormalities and is one of the most common causes of intractable epilepsy in children and young adults. Outcomes after surgery for FCD are highly variable, and prognosticators of seizure freedom are unclear. In a subset of FCDs, a transmantle sign is observed on imaging that focally spans the entire cerebral mantle from the ventricle to the cortical surface. The aim of this study was to characterize seizure control outcomes and prognostic significance of the transmantle sign in FCD epilepsy.


METHODS
Fourteen patients with the transmantle sign underwent epilepsy surgery for medically refractory epilepsy. Thirteen patients underwent resective surgery and 1 underwent multiple subpial transections with vagus nerve stimulator placement. Patient demographics, MRI, electroencephalography, intraoperative electrocorticography (ECoG), and pathology were reviewed. The results of this series were compared with those of 114 previously reported patients with FCD without the transmantle sign.


RESULTS
All patients were found to have childhood seizure onset and concordant MRI and ECoG findings. The primary MRI findings associated with transmantle sign included gray-white junction blurring, appearance of cortical thickening, T2 or FLAIR abnormality, and bottom-of-the-sulcus dysplasia. The transmantle sign was usually a focal finding, typically confined to 1 or several gyri with well-circumscribed epileptic tissue. Correlation of the transmantle sign with FCD histopathological subtypes was highly variable. Patients who underwent complete resection of MRI and ECoG abnormalities (12 of 13 patients) became seizure free. When compared with 114 FCD patients without the transmantle sign, patients with the transmantle sign showed significantly improved seizure-free outcomes after complete resections (p = 0.04).


CONCLUSIONS
The presence of the transmantle sign in patients with medically refractory partial epilepsy is associated with highly favorable seizure control outcomes after surgical treatment.
An Architecture for Modular Data Centers

Large numbers of low-cost, low-reliability commodity components are rapidly replacing high-quality, mainframe-class systems in data centers. These commodity clusters are far less expensive than the systems they replace, but they can bring new administrative costs in addition to heat and power-density challenges. This proposal introduces a data center architecture based upon macro-modules of standard shipping containers that optimizes how server systems are acquired, administered, and later recycled.
An angiographic analysis of atherosclerosis progression in below-the-knee arteries after femoropopliteal angioplasty in claudicants.

PURPOSE
To report an angiographic investigation of midterm atherosclerotic disease progression in below-the-knee (BTK) arteries of claudicants.


METHODS
Angiograms were performed in 58 consecutive claudicants (35 men; mean age 68.3+/-8.7 years) with endovascular treatment of femoropopliteal arteries in 58 limbs after a mean follow-up of 3.6+/-1.2 years. Angiograms were reviewed in consensus by 2 experienced readers blinded to clinical data. Progression of atherosclerosis in 4 BTK arterial segments (tibioperoneal trunk, anterior and posterior tibial arteries, and peroneal artery) was assessed according to the Bollinger score. The composite per calf Bollinger score represented the average of the 4 BTK arterial segment scores. The association of the Bollinger score with cardiovascular risk factors and gender was scrutinized.


RESULTS
A statistically significant increase in atherosclerotic burden was observed for the mean composite per calf Bollinger score (5.7+/-8.3 increase, 95% CI 3.5 to 7.9, p<0.0001), as well as for each single arterial segment analyzed. In multivariate linear regression analysis, diabetes mellitus was associated with a more pronounced progression of atherosclerotic burden in crural arteries (beta: 5.6, p = 0.035, 95% CI 0.398 to 10.806).


CONCLUSION
Progression of infrapopliteal atherosclerotic lesions is common in claudicants during midterm follow-up. Presence of diabetes mellitus was confirmed as a major risk factor for more pronounced atherosclerotic BTK disease progression.
The tourist loyalty index : A new indicator for measuring tourist destination loyalty ?

The measurement of loyalty is a topic of great interest for the marketing academic literature. The relation that loyalty has with the results of organizations has been tested by numerous studies and the search to retain profitable customers has become a maxim in firm management. Tourist destinations have not remained oblivious to this trend. However, the difficulty involved in measuring the loyalty of a tourist destination is a brake on its adoption by those in charge of destination management. The usefulness of measuring loyalty lies in being able to apply strategies which enable improving it, but that also impact on the enhancement of the organization’s results. The study of tourists’ loyalty to a destination is considered relevant for the literature and from the point of view of the management of the multiple actors involved in the tourist activity. Based on these considerations, this work proposes a synthetic indictor that allows the simple measurement of the tourist’s loyalty. To do so, we used as a starting point Best’s (2007) customer loyalty index adapted to the case of tourist destinations. We also employed a variable of results – the tourist’s overnight stays in the destination – to create a typology of customers according to their levels of loyalty and the number of their overnight stays. The data were obtained from a survey carried out with 2373 tourists of the city of Seville. In accordance with the results attained, the proposal of the synthetic indicator to measure tourist loyalty is viable, as it is a question of a simple index constructed from easily obtainable data. Furthermore, four groups of tourists have been identified, according to their degree of loyalty and profitability, using the number of overnight stays of the tourists in their visit to the destination. The study’s main contribution stems from the possibility of simply measuring loyalty and from establishing four profiles of tourists for which marketing strategies of differentiated relations can be put into practice and that contribute to the improvement of the destination’s results. © 2018 Journal of Innovation & Knowledge. Published by Elsevier España, S.L.U. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/
Virtual Embodiment: A Scalable Long-Term Strategy for Artificial Intelligence Research

Meaning has been called the “holy grail” of a variety of scientific disciplines, ranging from linguistics to philosophy, psychology and the neurosciences [1]. The field of Artifical Intelligence (AI) is very much a part of that list: the development of sophisticated natural language semantics is a sine qua non for achieving a level of intelligence comparable to humans. Embodiment theories in cognitive science hold that human semantic representation depends on sensori-motor experience [2]; the abundant evidence that human meaning representation is grounded in the perception of physical reality leads to the conclusion that meaning must depend on a fusion of multiple (perceptual) modalities [3]. Despite this, AI research in general, and its subdisciplines such as computational linguistics and computer vision in particular, have focused primarily on tasks that involve a single modality. Here, we propose virtual embodiment as an alternative, long-term strategy for AI research that is multi-modal in nature and that allows for the kind of scalability required to develop the field coherently and incrementally, in an ethically responsible fashion.
Perioperative complications and reoperations after incontinence and prolapse surgeries using prosthetic implants.

OBJECTIVE
To estimate the perioperative complication and reoperation rates associated with slings and prolapse repairs using mesh and biologic grafts.


METHODS
Analysis of all female members of Kaiser Permanente Southern and Northern California and Hawaii who underwent sling procedures or pelvic organ prolapse surgeries using implanted grafts or mesh between September 1, 2008, and May 31, 2010. Physicians' Current Procedural Terminology Coding System, 4th edition, International Classification of Diseases, 9th Revision, and surgical implant logs were used to identify the procedures performed, implants used, perioperative complications, and readmissions and reoperations within 12 months of the index surgery.


RESULTS
During the 21-month period, 4,142 women (mean age 57 years [standard deviation 12.2], median parity 3 [interquartile range 1-4], median body mass index 28 [interquartile range 25-32]) underwent 3,747 (71%) slings and 1,508 (29%) prolapse repair procedures using implanted prostheses. Trocar-related bladder perforations (51 of 3,747 [1.4%]) occurred more commonly than urethral perforations (2 of 3,747 [0.05%]) in sling procedures (P<.001). There were no trocar-related injuries for prolapse repair kit procedures. Mesh-related reoperations after sling procedures were performed for voiding dysfunction or urinary retention (49 of 3,747 [1.3%]), vaginal mesh erosion (30 of 3,747 [0.8%]), and urethral erosion (3 of 3,747 [0.08%]). Reoperations after prolapse procedures were performed more often for vaginal mesh erosion (29 of 858 [3%]) than for biologic graft infection (2 of 650 [0.3%]; P=.01) and were performed more commonly after anterior (19 of 307 [6%]) compared with apical (9 of 487 [2%]) or posterior vaginal mesh repairs (1 of 64 [2%]; P=.018).


CONCLUSION
Reoperations for mesh-related complications occurred most often after transvaginal mesh placement in the anterior vagina.
Volume of ambulatory care visits and patterns of care for patients diagnosed with plantar fasciitis: a national study of medical doctors.

BACKGROUND
Plantar fasciitis is a relatively common disorder of the foot, yet little is known about its prevalence, what types of physicians see patients with the disorder, or how, on a national scale, patients are typically managed. The purpose of this study was to generate national estimates of the volume of patient visits and characteristics of care given to patients diagnosed with plantar fasciitis by medical doctors.


METHODS
Data from the National Ambulatory Medical Care Survey (NAMCS) and the National Hospital Ambulatory Medical Care Survey (NHAMCS) for the years 1995-2000 were studied. These are multistage probability sample surveys of visits to office-based physicians (NAMCS) and visits to nonfederal, short-stay, and general hospitals (NHAMCS) to consult doctors of medicine and doctors of osteopathy. Sample data have been weighted to produce national estimates. Data describing the number of patient visits for plantar fasciitis and the characteristics of the care given during those visits were summarized using univariate analyses. Data were combined for the 6-year period to increase the reliability of the estimates, and figures are presented as annual averages.


RESULTS
Approximately 1 million patient visits per year were made to office-based physicians and hospital outpatient departments for the diagnosis and treatment of plantar fasciitis during 1995-2000. Approximately 62% of all visits were made to primary care practitioners, and 31% were made to orthopaedic surgeons. Patient visits for plantar fasciitis accounted for approximately 1% of all patient visits to orthopedic surgeons. Pain medication, including nonsteroidal anti-inflammatory drugs (NSAIDs), was the most frequently used intervention (47% of visits). Exercise counseling was cited at 26% of visits, and physical therapy was ordered or provided at 19% of visits.


CONCLUSIONS
This research suggests that plantar fasciitis is a relatively common disorder that is seen by several physician specialties. The disorder is not managed in a consistent way. Rather, there appears to be a large amount of variation in the way that these patients are managed. These findings support the argument that additional research is needed to identify effective interventions for plantar fasciitis and to determine if physician specialty influences treatment outcome.
Localization of the bronchodilator effect induced by type A natriuretic peptide in asthmatic subjects

Type A natriuretic peptide (CDD/ANP99-126) in its circulating form was analyzed with respect to the localization of its bronchodilating effects in asthmatic subjects in vivo. The intravenous infusion of 5.7, 11.4, and 17.1 pmol kg−1 min− CDD/ANP-99-126 caused a significant bronchodilation of both central and peripheral airways. While the localization of the bronchodilating effects was similar to β2-agonists, an improvement in lung function parameters comparable to these substances was not observed. But other members of the natriuretic peptide family may reveal a stronger bronchodilating potency.
Influence in Ratings-Based Recommender Systems: An Algorithm-Independent Approach

Recommender systems have been shown to help users find items of interest from among a large pool of potentially interesting items. Influence is a measure of the effect of a user on the recommendations from a recommender system. Influence is a powerful tool for understanding the workings of a recommender system. Experiments show that users have widely varying degrees of influence in ratings-based recommender systems. Proposed influence measures have been algorithm-specific, which limits their generality and comparability. We propose an algorithm-independent definition of influence that can be applied to any ratings-based recommender system. We show experimentally that influence may be effectively estimated using simple, inexpensive metrics.
Application of Neural Networks in Financial Data Mining

This paper deals with the application of a well-known neural network technique, multi-layer back-propagation (BP) neural network, in financial data mining. A modified neural network forecasting model is presented, and an intelligent mining system is developed. The system can forecast the buying and selling signs according to the prediction of future trends to stock market, and provide decision-making for stock investors. The simulation result of seven years to Shanghai Composite Index shows that the return achieved by this mining sys-tem is about three times as large as that achieved by the buy and hold strategy, so it is advantageous to apply neural networks to forecast financial time series, the different investors could benefit from it. Keywords—data mining, neural network, stock forecasting.
Impact of live interactive teledermatology on diagnosis, disease management, and clinical outcomes.

OBJECTIVE
To assess the impact of live interactive teledermatology consultations on changes in diagnosis, disease management, and clinical outcomes.


DESIGN
We conducted a retrospective analysis of 1500 patients evaluated via live interactive teledermatology between 2003 and 2005 at the University of California, Davis. We compared diagnoses and treatment plans between the referring physicians and the teledermatologists. Patients with 2 or more teledermatology visits within a 1-year period were assessed for changes in clinical outcomes.


SETTING
Academic medical center with an established teledermatology program since 1996.


PARTICIPANTS
Medical records were evaluated for 1500 patients who underwent live interactive teledermatology consultation. Patients seen for more than 1 teledermatology visit were included in the clinical outcome assessment.


INTERVENTION
Live interactive teledermatology consultation.


MAIN OUTCOME MEASURES
Changes in diagnosis, disease management, and clinical outcome.


RESULTS
Compared with diagnoses and treatment plans from referring physicians, the 1500 live interactive teledermatology consultations resulted in changes in diagnosis in 69.9% of patients and changes in disease management in 97.7% of patients. Among 313 patients with at least 2 teledermatology visits within 1 year, clinical improvement was observed in 68.7% of patients. Multivariate analysis showed that changes in diagnosis (P = .01), changes in disease management (P < .001), and the number of teledermatology visits (P < .001) were significantly associated with improved clinical outcomes.


CONCLUSIONS
Live interactive teledermatology consultations result in changes in diagnosis and disease management in most consultations. The numbers of live interactive teledermatology visits and changes in diagnosis and disease management are significantly associated with improved clinical outcomes.