LLukas22/scidocs huggingface dataset:
NG2 expression predicts the metastasis formation in soft-tissue sarcoma patients.

Enhanced expression levels of NG2 proteoglycan in presurgical original lesions of soft-tissue sarcoma (STS) patients defines with 55% probability the immediate (i.e., within 12 months postsurgery) risk in these individuals to develop postsurgical secondary lesions, independently of any other clinical trait. It, therefore, provides a molecular factor that alone prospects a particularly unfavorable clinical outcome in such patients. Evaluation of the timing of metastasis formation in patients with high and low levels of NG2 in their primitive lesions further stratified the patients in subsets with diverse lag phases in the occurrence of metastatic disease. In our cohort of high-grade STS cases, transcription of NG2 also showed a 81-fold amplification in metastatic lesions, when compared to primitive ones, and this gene overexpression was accompanied by an abundant but nonuniform in situ expression of its product. In a similar manner as seen in primitive lesions, patients with higher levels of metastatic NG2 encountered a significantly more dismal clinical course. Multivariate analysis asserted that in these individuals upregulation of NG2 represented an absolute independent prognostic parameter. Therefore, minimally invasive assessment of the transcription levels of the NG2 gene represents a parameter capable of predicting the arising of metastatic disease within a definite postsurgery time interval, and affords in adjunct in the definition of life expectance in STS patients.
Small-dose ketamine improves the postoperative state of depressed patients.

UNLABELLED
We investigated whether ketamine is suitable for depressed patients who had undergone orthopedic surgery. We studied 70 patients with major depression and 25 patients as the control (Group C). The depressed patients were divided randomly into two groups; patients in Group A (n = 35) were induced with propofol, fentanyl, and ketamine and patients in Group B (n = 35) were induced with propofol and fentanyl, and all patients were maintained with 1.5%-2.0% isoflurane plus nitrous oxide. The mean Hamilton Depression Rating (HDR) score was 12.7 +/- 5.4 for Group A and 12.3 +/- 6.0 for Group B 2 days before surgery and 9.9 +/- 4.1 for Group A and 14.4 +/- 3.8 for Group B 1 day after surgery. The HDR score in Group A 1 day after surgery was significantly (P < 0.05) lower than that in Group B. The HDR score in Group C was 4.2 +/- 1.7 2 days before surgery and 4.8 +/- 1.6 1 day after surgery. Depressed mood, suicidal tendencies, somatic anxiety, and hypochondriasis significantly decreased in Group A as compared with Group B. Postoperative pain scores in Group A at 8 and 16 h after the end of anesthesia were 26.6 +/- 8.7 and 24.9 +/- 8.2, respectively, which were significantly (P < 0.05) lower than 34.3 +/- 12.0 and 31.1 +/- 8.8 in Group B. In conclusion, small-dose ketamine improved the postoperative depressive state and relieved postoperative pain in depressed patients.


IMPLICATIONS
NMDA receptor antagonists are reported to be effective for improving depression. It remains unclear whether ketamine, which is an NMDA receptor antagonist, postoperatively affects the psychological state in depressed patients. We investigated the effect of 1.0 mg/kg of ketamine on postoperative outcomes in depressed patients.
Integrating rural development and biodiversity conservation in Central Romania

Unlike most parts of the European Union (EU), Southern Transylvania (Central Romania) is characterized by an exceptionally high level of farmland biodiversity. This results from traditional small-scale farming methods that have maintained extensive areas of high nature value farmland. Following the post-socialist transition, Southern Transylvania faces serious challenges such as under-employment and rural population decline, which put traditional farming at risk. With Romania’s accession to the EU in 2007, Southern Transylvania became part of a complex multi-level governance system that in principle provides mechanisms to balance biodiversity conservation and rural development. To this end, the most important instruments are the ‘Natura 2000’ network of protected areas and EU rural development policy. Structured questionnaires and semi-structured interviews with town hall representatives from 30 villages in Southern Transylvania and local EU experts revealed that EU policies are often poorly aligned with local conditions. To date, the implementation of EU rural development policy is strongly focused on economic development, with biodiversity conservation being of little concern. Moreover, relevant EU funding opportunities are poorly communicated. Bridging organizations should be strengthened to foster the implementation of a rural development strategy that integrates local needs and biodiversity conservation.
Bitcoin, an SWOT analysis

In the year 2009, a new virtual currency called Bitcoin was introduced to the world. Bitcoin generation and transactions are based on hashes and asymmetric encryption algorithms. Bitcoin is the first attempt at creating a decentralized virtual currency with no central bank or financial entity controlling it and is very attractive to different demographies of users. A lot of misunderstanding and doubt surrounds Bitcoin. Based on studying the few years of Bitcoin's circulation and usage, we presented the strengths and weaknesses of Bitcoin and analyzed what opportunities and threats it faces in the current financial environment. We summarized the strengths, weaknesses, opportunities and threats for Bitcoin in an SWOT analysis. We concluded that the most important factors to influence the future of Bitcoin circulation and price are technological advances and people's openness to Bitcoin, the intervention of governments and financial powers by creating laws around cryptocurrencies and external events that are closely tied to the Bitcoin community.
The Effects of Seed Mass on Germination, Seedling Emergence, and Early Seedling Growth of Eastern White Pine (Pinus strobus L.)

Half-sib seed of several eastern white pine (Pinus strobus L.) families was used to examine seed mass effects on laboratory germination, and seedling emergence and growth under moderate and low light (47 and 13% full sunlight) in a greenhouse. Percent germination and speed of germination under laboratory conditions were not related to seed mass among half-sib families or multi-family seedlots bulked by seed mass. Percent seedling emergence in the greenhouse was not related to seed mass, but families with heavier seeds exhibited faster emergence. Both rate and percent emergence were significantly increased under low light. Family differences in leaf, stem, root, and total seedling dry mass, primary root length, and the number of first-order-lateral-roots were positively related to seed mass in both light environments. Low light diminished the absolute biomass increment per unit seed mass, but the proportional change in biomass with seed mass was similar between light environments. Rate of emergence also influenced seedling size within families, with earlier emergence increasing seedling dry mass from 7 to 58%, dependent on light environment. Biomass partitioning coefficients were influenced by light environment but largely independent of seed mass.
A Chatbot-based Interactive Question Answering System

Interactive question answering (QA) systems, where a dialogue interface enables followup and clarification questions, are a recent field of research. We report our experience on the design, implementation and evaluation of a chatbot-based dialogue interface for our open-domain QA system, showing that chatbots can be effective in supporting interactive QA.
Corporate Venture Capital, Value Creation, and Innovation

We analyze how corporate venture capital (CVC) differs from independent venture capital (IVC) in nurturing innovation in entrepreneurial firms. We find that CVC-backed firms are more innovative, as measured by their patenting outcome, although they are younger, riskier, and less profitable than IVC-backed firms. Our baseline results continue to hold in a propensity score matching analysis of IPO firms and a difference-in-differences analysis of the universe of VC-backed entrepreneurial firms. We present evidence consistent with two possible underlying mechanisms: CVC’s greater industry knowledge due to the technological fit between their parent firms and entrepreneurial firms and CVC’s greater tolerance for failure. (JEL G24, G23, O31)
Career optimism: The roles of contextual support and career decision-making self efficacy

Article history: Received 23 October 2014 Available online 8 February 2015 Drawing from the social cognitive theory (Bandura, 1986), we examined the role of parental support, teacher support, and career decision-making self-efficacy as sources of career optimism. We tested our proposed model using 235 computer science majors from a large university in the Philippines. Surveys were conducted over two measurement periods (1 year apart). Results revealed that Time 1 parental and teacher support were positively associated with Time 2 career optimism. Furthermore, we found that these direct relationships were fully mediated by Time 1 career decision-making self-efficacy. These results remained significant even after controlling for neuroticism and past performance. Theoretical and practical implications are discussed. © 2015 Elsevier Inc. All rights reserved.
A robust micro-vibration sensor for biomimetic fingertips

Controlling grip force in a prosthetic or robotic hand requires detailed sensory feedback information about microslips between the artificial fingertips and the object. In the biological hand this is accomplished with neural transducers capable of measuring micro-vibrations in the skin due to sliding friction. For prosthetic tactile sensors, emulating these biological transducers is a difficult challenge due to the fragility associated with highly sensitive devices. Incorporating a pressure sensor into a fluid-filled fingertip provides a novel solution to this problem by effectively creating a device similar to a hydrophone, capable of recording vibrations from lateral movements. The fluid conducts these acoustic signals well and with little attenuation, permitting the pressure sensing elements to be located in a protected region inside the core of the sensor and removing them from harmpsilas way. Preliminary studies demonstrate that high frequency vibrations (50-400 Hz) can be readily detected when such a fingertip slides across a ridged surface.
Mechanical properties and microstructure analysis of fly ash geopolymeric recycled concrete.

Six mixtures with different recycled aggregate (RA) replacement ratios of 0%, 50% and 100% were designed to manufacture recycled aggregate concrete (RAC) and alkali-activated fly ash geopolymeric recycled concrete (GRC). The physical and mechanical properties were investigated indicating different performances from each other. Optical microscopy under transmitted light and scanning electron microscopy (SEM) coupled with energy dispersive X-ray spectroscopy (EDX) were carried out in this study in order to identify the mechanism underlying the effects of the geopolymer and RA on concrete properties. The features of aggregates, paste and interfacial transition zone (ITZ) were compared and discussed. Experimental results indicate that using alkali-activated fly ash geopolymer as replacement of ordinary Portland cement (OPC) effectively improved the compressive strength. With increasing of RA contents in both RAC and GRC, the compressive strength decreased gradually. The microstructure analysis shows that, on one hand, the presence of RA weakens the strength of the aggregates and the structure of ITZs; on the other hand, due to the alkali-activated fly ash in geopolymer concrete, the contents of Portlandite (Ca(OH)(2)) and voids were reduced, as well as improved the matrix homogeneity. The microstructure of GRC was changed by different reaction products, such as aluminosilicate gel.
Prognostic impact of different regional referral practices for interventional investigation and coronary treatment after exercise testing: a population-based 5-year follow-up study.

OBJECTIVE
To examine the association among different centres' referral practices for coronary angiography (CAG) after exercise testing, with 1- and 5-year outcomes.


DESIGN
Observational population-based cohort study.


SETTING
All 10 hospitals and six private practising consultants in Aarhus and Ringkjoebing counties (900 000 inhabitants), Denmark.


SUBJECTS
All patients who in 1996 had an abnormal bicycle exercise test (n = 736).


MEASUREMENTS
Referral for CAG, coronary intervention, cardiovascular and all-cause mortality, and myocardial infarction (MI).


RESULTS
As an immediate consequence of the exercise test, 60.7% of subjects were referred for CAG. Based on the centres' fraction of patients referred for CAG, three categories of centres were defined: low (<33%), intermediate (33-66%) and high (>66%). A low compared with a high referral fraction was associated with a similar 5-year mortality and MI ratio [all-cause/cardiovascular mortality rate ratio (RR) = 1.33, 95% confidence interval (CI): 0.45-3.92/RR = 0.62, 95% CI: 0.25-1.57; and MI RR = 0.92, 95% CI: 0.45-1.86]. The same was found for an intermediate compared with a high fraction (all-cause/cardiovascular mortality RR = 0.92, 95% CI: 0.49-1.72/RR = 0.74, 95% CI: 0.42-1.33; and MI RR = 1.07, 95% CI: 0.68-1.70). Estimates were about the same after 1 year of follow-up with no major differences among centres in mortality or MI.


CONCLUSIONS
Centres' different referral practices for interventional investigation and treatment were not associated significantly with short-term or long-term mortality or MI among patients with an abnormal exercise test.
RFID Based Exam Hall Maintenance System

Seating Arrangement of students during examinations is distributed. Students face difficulties as they have to scrounge for their examination hall numbers and seating arrangement while they are wits end. An innovation which could aid the students in finding their exam halls and seats would be welcoming and very rewarding. This paper “RFID BASED EXAM HALL MAINTENANCE SYSTEM”, presents a modernized method of examination hall management. It is possible for a student to identify the particular exam hall from any other hall, when they swipe RFID card in a card reader located there. This helps them to identify the floor or get directions to their respective halls without delays. The card reader is provided at the entrance of the building, if the students enters wrongly a buzzer alarm sets off, otherwise the room number is displayed on the LCD, connected to controller.
Towards a Human Task Management Reference Model

Business process engines and workflow engines (but also web applications and emails) provide information about human tasks to people. Although many of these systems support some kind of human task management, no extensive analysis of involved components has been undertaken. This paper discusses some of these systems exemplarily and defines a first human task reference model to stimulate debates on ways how to manage human tasks crossing system and organization boundaries.
Scalp hypothermia to prevent chemotherapy-induced alopecia is effective and safe: A pilot study of a new digitized scalp-cooling system used in 74 patients

 Goals. The aim of this study was to examine the efficacy and safety of a new digitized, controlled, scalp-cooling system to prevent chemotherapy-induced alopecia. Method. Seventy-four female cancer patients who received 13 varying chemotherapy regimens were included in a nonrandomized pilot study. The Digni 2–3 with Dignicap system consists of a refrigerator unit and a control unit integrated into a mobile cabinet and connected to a tight-fitting cooling cap. This system maintains a constant scalp temperature of +5°C for many hours. In this study, 60 patients were treated for ovarian cancer with either taxane or epirubicin combination chemotherapy. Eight patients with Hodgkin's lymphoma, three with breast cancer, two with endometrial cancer, and one with sarcoma were also included. Photo documentation and patient assessment of hair loss and discomfort were performed. Results. In anthracycline-treated patients, total prevention of hair loss was observed, whereas hair loss in paclitaxel/docetaxel-treated patients was minimal to none. The combination of anthracycline and taxane resulted in more hair loss, but only three of six patients used a wig. Scalp cooling was generally very well tolerated; only two of 74 patients discontinued use of the cold cap due to discomfort. No scalp metastases occurred over a median follow-up period of 15 months. Conclusions. The digitized, controlled, scalp-cooling system represents an effective and safe device that should be clinically evaluated in a randomized trial and in studies using other chemotherapy regimens to determine optimal temperatures and durations of cooling for maximal efficacy.
CA-125 can be part of the tumour evaluation criteria in ovarian cancer trials: experience of the GCIG CALYPSO trial

Background:CA-125 as a tumour progression criterion in relapsing ovarian cancer (ROC) trials remains controversial. CALYPSO is a large randomised trial incorporating CA-125 (GCIG criteria) and symptomatic deterioration in addition to Response Evaluation Criteria in Solid Tumours (RECIST) criteria (radiological) to determine progression.Methods:In all, 976 patients with platinum-sensitive ROC were randomised to carboplatin–paclitaxel (C-P) or carboplatin-pegylated liposomal doxorubicin (C-PLD). CT-scan and CA-125 were performed every 3 months until progression.Results:In all, 832 patients (85%) progressed, with 60% experiencing a first radiological progression, 10% symptomatic progression, and 28% CA-125 progression without evidence of radiological or symptomatic progression. The benefit of C-PLD vs C-P in progression-free survival was not influenced by type of first progression (hazard ratio 0.85 (95% confidence interval (CI): 0.66–1.10) and 0.84 (95% CI: 0.72–0.98) for CA-125 and RECIST, respectively). In patients with CA-125 first progression who subsequently progressed radiologically, a delay of 2.3 months was observed between the two progression types. After CA-125 first progression, median time to new treatment was 2.0 months. In all, 81%of the patients with CA-125 or radiological first progression and 60% with symptomatic first progression received subsequent treatment.Conclusion:CA-125 and radiological tests performed similarly in determining progression with C-PLD or C-P. Additional follow-up with CA-125 measurements was not associated with overtreatment.
Depression in Patients with Mastocytosis: Prevalence, Features and Effects of Masitinib Therapy

Depression in patients with mastocytosis is often reported but its prevalence and characteristics are not precisely described. In addition, the impact of therapies targeting mast cells proliferation, differentiation and degranulation on psychic symptoms of depression have never been investigated. Our objective was to determine the prevalence and to describe features of depression in a large cohort of mastocytosis patients (n = 288) and to investigate the therapeutic impact of the protein kinase inhibitor masitinib in depression symptoms. The description of depression was based on the analysis of a database with Hamilton scores using Principal Component Analysis (PCA). Efficacy of masitinib therapy was evaluated using non parametric Wilcoxon test for paired data within a three months period (n = 35). Our results show that patients with indolent mastocytosis present an elevated prevalence of depression (64%). Depression was moderate in 56% but severe in 8% of cases. Core symptoms (such as psychic anxiety, depressed mood, work and interests) characterized depression in mastocytosis patients. Masitinib therapy was associated with significant improvement (67% of the cases) of overall depression, with 75% of recovery cases. Global Quality of Life slightly improved after masitinib therapy and did not predicted depression improvement. In conclusion, depression is very frequent in mastocytosis patients and masitinib therapy is associated with the reduction its psychic experiences. We conclude that depression in mastocytosis may originate from processes related to mast cells activation. Masitinib could therefore be a useful treatment for mastocytosis patients with depression and anxiety symptoms.
Qualify: a randomized head-to-head study of aripiprazole once-monthly and paliperidone palmitate in the treatment of schizophrenia

OBJECTIVE
To directly compare aripiprazole once-monthly 400mg (AOM 400) and paliperidone palmitate once-monthly (PP) on the Heinrichs-Carpenter Quality-of-Life Scale (QLS), a validated health-related quality of life and functioning measure in schizophrenia.


METHOD
This 28-week, randomized, non-inferiority, open-label, rater-blinded, head-to-head study (QUALIFY) of AOM 400 and PP in adult patients (18-60 years) comprised oral conversion, initiation of AOM 400 or PP treatment, and continuation with intramuscular injections every 4weeks. The primary endpoint assessed non-inferiority and superiority on QLS total score analyzed using a mixed model for repeated measurements.


RESULTS
Of 295 randomized patients, 100/148 (67.6%) of AOM 400 and 83/147 (56.5%) of PP patients completed 28weeks of treatment. A statistically significant least squares mean difference in change from baseline to week 28 on QLS total score (4.67 [95%CI: 0.32;9.02], p=0.036) confirmed non-inferiority and established superiority of AOM 400 vs PP. There were also significant improvements in Clinical Global Impression - Severity scale and the Investigator's Assessment Questionnaire for AOM 400 vs PP, and pre-defined sub-group analyses revealed a consistent pattern of significance favoring AOM 400 in patients ≤35years. Common treatment-emergent adverse events in the treatment continuation phase were more frequent with PP vs AOM 400, and adverse events were the most frequent reason for discontinuation (27/137 [19.7%] for PP and 16/144 [11.1%] for AOM 400). All-cause discontinuation was numerically lower with AOM 400.


CONCLUSION
Superior improvements on clinician-rated health-related quality of life and a favorable tolerability profile suggest greater overall effectiveness for aripiprazole once-monthly vs paliperidone palmitate. ClinicalTrials.gov identifier:NCT01795547.