LLukas22/scidocs huggingface dataset:
Renal function in pediatric liver transplantation: a long-term follow-up study.

BACKGROUND
Renal impairment is a frequent complication after orthotopic liver transplantation (OLT). However, most studies in children use inaccurate renal assessment based on serum creatinine, and long-term follow-up data are lacking. The purpose of this study was to determine incidence, determinants, and progression of long-term chronic renal insufficiency (CRI) in a single-center series of pediatric liver transplant recipients.


METHODS
The true glomerular filtration rate was measured by inulin clearance before and serially after OLT in 69 consecutive patients followed more than 2 years after transplantation. Cumulative incidence of CRI (glomerular filtration rate<60 mL/min/1.73 m2) was determined using a Kaplan-Meier method. A Cox proportional hazard model was performed to identify predictors of CRI.


RESULTS
The median age at OLT was 3.2 years. The median follow-up time after OLT was 9.3 years (interquartile range 6.3-11.9). At 10 years post-OLT, the cumulative incidence of CRI was 25%. In a multivariate Cox regression model, arterial hypertension during follow-up as time dependant variable (P=0.03), cyclosporine as primary immunosuppression (P=0.048), and liver diseases with potential renal involvement including inborn errors of metabolism, Alagille syndrome, and hepatic fibrosis (P=0.003) were associated with CRI.


CONCLUSIONS
Renal function is a major concern long after OLT in children. Renal dysfunction post-OLT may be reduced by optimal control of arterial hypertension, immunosuppression protocols adapted to primary liver disease, and calcineurin inhibitor sparing regimen.
Study protocol of a randomized controlled trial comparing Mindfulness-Based Stress Reduction with treatment as usual in reducing psychological distress in patients with lung cancer and their partners: the MILON study

Lung cancer is the leading cause of cancer death worldwide and characterized by a poor prognosis. It has a major impact on the psychological wellbeing of patients and their partners. Recently, it has been shown that Mindfulness-Based Stress Reduction (MBSR) is effective in reducing anxiety and depressive symptoms in cancer patients. The generalization of these results is limited since most participants were female patients with breast cancer. Moreover, only one study examined the effectiveness of MBSR in partners of cancer patients. Therefore, in the present trial we study the effectiveness of MBSR versus treatment as usual (TAU) in patients with lung cancer and their partners. A parallel group, randomized controlled trial is conducted to compare MBSR with TAU. Lung cancer patients who have received or are still under treatment, and their partners are recruited. Assessments will take place at baseline, post intervention and at three-month follow-up. The primary outcome is psychological distress (i.e. anxiety and depressive symptoms). Secondary outcomes are quality of life (only for patients), caregiver appraisal (only for partners), relationship quality and spirituality. In addition, cost-effectiveness ratio (only in patients) and several process variables are assessed. This trial will provide information about the clinical and cost-effectiveness of MBSR compared to TAU in patients with lung cancer and their partners. ClinicalTrials.gov NCT01494883 .
United Kingdom back pain exercise and manipulation (UK BEAM) randomised trial: cost effectiveness of physical treatments for back pain in primary care.

OBJECTIVE
To assess the cost effectiveness of adding spinal manipulation, exercise classes, or manipulation followed by exercise ("combined treatment") to "best care" in general practice for patients consulting with low back pain.


DESIGN
Stochastic cost utility analysis alongside pragmatic randomised trial with factorial design.


SETTING
181 general practices and 63 community settings for physical treatments around 14 centres across the United Kingdom.


PARTICIPANTS
1287 (96%) of 1334 trial participants.


MAIN OUTCOME MEASURES
Healthcare costs, quality adjusted life years (QALYs), and cost per QALY over 12 months.


RESULTS
Over one year, mean treatment costs relative to "best care" were 195 pounds sterling (360 dollars; 279 euros; 95% credibility interval 85 pounds sterling to 308 pounds sterling) for manipulation, 140 pounds sterling (3 pounds sterling to 278 pounds sterling) for exercise, and 125 pounds sterling (21 pounds sterling to 228 pounds sterling) for combined treatment. All three active treatments increased participants' average QALYs compared with best care alone. Each extra QALY that combined treatment yielded relative to best care cost 3800 pounds sterling; in economic terms it had an "incremental cost effectiveness ratio" of 3800 pounds sterling. Manipulation alone had a ratio of 8700 pounds sterling relative to combined treatment. If the NHS was prepared to pay at least 10,000 pounds sterling for each extra QALY (lower than previous recommendations in the United Kingdom), manipulation alone would probably be the best strategy. If manipulation was not available, exercise would have an incremental cost effectiveness ratio of 8300 pounds sterling relative to best care.


CONCLUSIONS
Spinal manipulation is a cost effective addition to "best care" for back pain in general practice. Manipulation alone probably gives better value for money than manipulation followed by exercise.
Ethics and responsibilities in a CDIO based software engineering process

The great impact that Software Engineering has had on society during the latest decades has put demands on that discipline to become a mature, as well as a trustworthy engineering discipline. Here, ...
A comparison of peer-to-peer architectures.

The large number of peer-to-peer file-sharing applications can be subdivided in three basic categories: having a mediated, pure or hybrid architecture. This paper details each of these and indicates their respective strengths and weaknesses. In addition to this theoretical study, a number of practical experiments were conducted, with special attention for three popular applications, representative of each of the three architectures. Although a number of measurement studies have been done in the past ([1], [3], etc.) these all investigate only a fraction of the available applications and architectures, with very little focus on the bigger picture and to the recent evolutions in peer-to-peer architectures.
Benefits of supervised group exercise programme for women being treated for early stage breast cancer: pragmatic randomised controlled trial.

OBJECTIVES
To determine functional and psychological benefits of a 12 week supervised group exercise programme during treatment for early stage breast cancer, with six month follow-up.


DESIGN
Pragmatic randomised controlled prospective open trial.


SETTING
Three National Health Service oncology clinics in Scotland and community exercise facilities.


PARTICIPANTS
203 women entered the study; 177 completed the six month follow-up.


INTERVENTIONS
Supervised 12 week group exercise programme in addition to usual care, compared with usual care.


MAIN OUTCOME MEASURES
Functional assessment of cancer therapy (FACT) questionnaire, Beck depression inventory, positive and negative affect scale, body mass index, seven day recall of physical activity, 12 minute walk test, and assessment of shoulder mobility.


RESULTS
Mixed effects models with adjustment for baseline values, study site, treatment at baseline, and age gave intervention effect estimates (intervention minus control) at 12 weeks of 129 (95% confidence interval 83 to 176) for metres walked in 12 minutes, 182 (75 to 289) for minutes of moderate intensity activity reported in a week, 2.6 (1.6 to 3.7) for shoulder mobility, 2.5 (1.0 to 3.9) for breast cancer specific subscale of quality of life, and 4.0 (1.8 to 6.3) for positive mood. No significant effect was seen for general quality of life (FACT-G), which was the primary outcome. At the six month follow-up, most of these effects were maintained and an intervention effect for breast cancer specific quality of life emerged. No adverse effects were noted.


CONCLUSION
Supervised group exercise provided functional and psychological benefit after a 12 week intervention and six months later. Clinicians should encourage activity for their patients. Policy makers should consider the inclusion of exercise opportunities in cancer rehabilitation services. Trial registration Current controlled trials ISRCTN12587864 [controlled-trials.com].
Fungal Culture and Sensitisation in Asthma, Cystic Fibrosis and Chronic Obstructive Pulmonary Disorder: What Does It Tell Us?

Collectively asthma, chronic obstructive pulmonary disorder (COPD) and cystic fibrosis (CF) are very common, important causes of disease and ill health. Filamentous fungal colonisation of the airways can occur in all three disease groups, although the clinical relevance is unclear. Allergic bronchopulmonary aspergillosis (ABPA) is a well-recognised severe complication of airway colonisation associated primarily with Aspergillus fumigatus. Fungal colonisation may have a deleterious effect without fulfilling all the diagnostic criteria of ABPA; however, a lack of standardisation in processing respiratory samples hampers comparisons. Whilst mycology laboratory accreditation programs are common, most countries have no national standard guidelines for processing respiratory samples. Fungal recovery from sputum in CF, asthma and COPD can be around 40, 54 and 49 %, respectively. Isolation of fungi from sputum has been associated with reduced lung function in asthma and CF, although no such associations have been found in COPD. It is unclear whether fungal colonisation contributes to lower lung function or is a marker of more severe lung disease and aggressive therapy. Fungal sensitisation may contribute to the persistence of active respiratory symptoms; however, the exact prevalence is unclear. Sensitisation to A. fumigatus has been associated with reduced lung function in asthma, COPD and CF. It has suggested that both skin prick tests and specific IgE measurement by the ImmunoCAP system should be used in diagnoses of allergy, due to discordance in test results; however, there is currently no widely adopted consensus as to which fungi to test for.
Diet quality of overweight and obese mothers and their preschool children.

BACKGROUND
Children of obese parents are more likely to become obese than children of normal-weight parents. However, there is little information regarding the diet intakes of children of obese parents.


OBJECTIVE
Our objective was to determine the diet quality of preschoolers and their overweight/obese mothers, whether maternal and child diet quality were correlated, and predictors of child's diet quality.


DESIGN
Results are from baseline measurements from a randomized controlled behavioral intervention.


PARTICIPANTS
Participants were English-literate, postpartum mothers and their preschoolers (n=177 mother-child dyads) in North Carolina. Visits took place in the Triangle and Triad regions of North Carolina between September 2007 and November 2009.


MAIN OUTCOME MEASURES
We measured diet quality of mothers and preschoolers using the Healthy Eating Index-2005.


STATISTICAL ANALYSES PERFORMED
Descriptive statistics, χ(2), analysis of variance, Pearson correlations, and stepwise regression models were used.


RESULTS
Only 11% of children and 7% of mothers had Healthy Eating Index-2005 scores ≥80. Most children did not meet recommendations for fruits, vegetables, whole grains, meat and beans, sodium, saturated fat, and energy from solid fat and added sugars. Child diet quality was correlated with maternal diet quality (r=0.44; P<0.001). However, children and mothers differed in the proportion that met food-group recommendations: children vs mothers: total fruit (50% vs 14%), whole fruit (46% vs 28%), total vegetables (6% vs 18%), dark green and orange vegetables and legumes (7% vs 19%), total grains (57% vs 71%), milk (63% vs 22%), and meat and beans (33% vs 60%). Maternal diet quality and household income were positively correlated with child diet quality.


CONCLUSIONS
The diets of children of overweight/obese mothers need improvement in several areas. Mother's diet quality and household income are important contributors to child's diet quality and should be considered in efforts to improve the diets of these children.
Impact of the phlebotomy training based on CLSI/NCCLS H03-A6 - procedures for the collection of diagnostic blood specimens by venipuncture.

INTRODUCTION
The activities involving phlebotomy, a critical task for obtaining diagnostic blood samples, are poorly studied as regards the major sources of errors and the procedures related to laboratory quality control. The aim of this study was to verify the compliance with CLSI documents of clinical laboratories from South America and to assess whether teaching phlebotomists to follow the exact procedure for blood collection by venipuncture from CLSI/NCCLS H03-A6 - Procedures for the Collection of Diagnostic Blood Specimens by Venipuncture might improve the quality of the process.


MATERIALS AND METHODS
A survey was sent by mail to 3674 laboratories from South America to verify the use of CLSI documents. Thirty skilled phlebotomists were trained with the CLSI H03-A6 document to perform venipuncture procedures for a period of 20 consecutive working days. The overall performances of the phlebotomists were further compared before and after the training program.


RESULTS
2622 from 2781 laboratories that did answer our survey used CLSI documents to standardize their procedures and process. The phlebotomists' training for 20 days before our evaluation completely eliminated non-conformity procedures for: i) incorrect friction of the forearm, during the cleaning of the venipuncture site to ease vein location; ii) incorrect sequence of vacuum tubes collection; and iii) inadequate mixing of the blood in primary vacuum tubes containing anticoagulants or clot activators. Unfortunately the CLSI H03-A6 document does not caution against both unsuitable tourniquet application time (i.e., for more than one minute) and inappropriate request to clench the fist repeatedly. These inadequate procedures were observed for all phlebotomists.


CONCLUSION
We showed that strict observance of the CLSI H03-A6 document can remarkably improve quality, although the various steps for collecting diagnostic blood specimens are not a gold standard, since they may still permit errors. Tourniquet application time and forearm clench should be verified by all quality laboratory managers in the services. Moreover, the procedure for collecting blood specimens should be revised to eliminate this source of laboratory variability and safeguard the quality.
Synchronous papillary carcinoma in thyroglossal duct cyst and thyroid gland: case report and review of literature.

BACKGROUND
We report a rare case of synchronous occurrence of thyroglossal duct cyst carcinoma and thyroid carcinoma and discuss its management in detail.


METHODS
A 59-year-old woman was clinically diagnosed to have a thyroglossal duct cyst and a solitary nodule. Fine-needle aspiration cytology revealed a papillary carcinoma in the thyroglossal duct cyst and a colloid in the thyroid nodule. Sistrunk's procedure along with a total thyroidectomy was performed followed by postoperative radioiodine ablation.


RESULTS
Histopathologic examination revealed thyroglossal duct cyst carcinoma and bilateral foci of papillary carcinoma in the thyroid gland. She has remained free of disease on follow-up.


CONCLUSION
Most cancers arising in thyroglossal duct cysts are of low risk, and Sistrunk's procedure is an adequate treatment for such cancers. However, for synchronously occurring cancers of the thyroglossal duct cyst and thyroid gland, or high-risk thyroglossal duct cyst cancers, more aggressive treatment comprising total thyroidectomy, Sistrunk's procedure, and radioiodine therapy is indicated.
Critical Omissions and New Directions for Sustainable Tourism: A Situated Macro–Micro Approach

This paper traces the history and evolution of sustainable tourism and identifies some critical issues and omissions in this and related approaches such as responsible tourism, ecotourism and pro-poor tourism. The academic, institutional and practical intersections of sustainable tourism and responsible tourism are examined. It reveals that important theoretical and practical considerations around well-being, inclusion, and sustainability have been omitted. A critical look at ecotourism reveals additional concerns, such as a cornucopia of guidelines and principles, without clear ethical justifications to support them. At the same time, academics in this domain have been slow to consider the modernist and neoliberal influences shaping ecotourism and sustainable tourism development, such as through the discourse of ecological modernization. We identify some key omissions, such as the missing ̳body‘ in sustainable tourism discourse, lack of critical analysis of postcolonial and dependency issues, and propose re-situating  ̳sustainable tourism‘ within a micro–macro, local-global systems approach informed by a clear framework of justice and ethics.
Radical Analyses of Imperialism, the Third World, and the Transition to Socialism: A Survey Article

THIS PAPER IS A SURVEY of Marxist and other radical interpretations of interactions among the three "worlds" of advanced capitalism, socialism, and the less developed countries (LDCs). It includes, first, analyses of the causes, aims, and methods of capitalist imperialism. The survey next examines the impact of world capitalism on LDCs, including theories of dependency and unequal exchange and the role of international agencies in the development process of LDCs. The third general topic is that of domestic policies of the LDCs, such as policies of import substitution and export promotion, as well as other social programs aiming for development. The survey, finally, extends to the efforts of some less-advanced countries to achieve socialist societies-that is, to issues of the transition process from precapitalist or immature capitalist economies to socialist ones. Wherever possible, we appraise or raise questions about the radical literature, for the purposes of guiding readers who are unfamiliar with the terrain and of stimulating radicals to improve their efforts in these areas. By radical literature we mean that which is highly critical of capitalism, favors socialism, and often employs Marxian analysis. Marxian analysis contains an economic interpretation of historical changes, which employs the categories of the productive forces, the relations of production, and the superstructure; the view of the primacy of the production process in establishing class structures, other social relations, and noneconomic institutions and
The consumption of Internet child pornography and violent and sex offending

BACKGROUND
There is an ongoing debate on whether consumers of child pornography pose a risk for hands-on sex offenses. Up until now, there have been very few studies which have analyzed the association between the consumption of child pornography and the subsequent perpetration of hands-on sex offenses. The aim of this study was to examine the recidivism rates for hands-on and hands-off sex offenses in a sample of child pornography users using a 6 year follow-up design.


METHODS
The current study population consisted of 231 men, who were subsequently charged with consumption of illegal pornographic material after being detected by a special operation against Internet child pornography, conducted by the Swiss police in 2002. Criminal history, as well as recidivism, was assessed using the criminal records from 2008.


RESULTS
4.8% (n = 11) of the study sample had a prior conviction for a sexual and/or violent offense, 1% (n = 2) for a hands-on sex offense, involving child sexual abuse, 3.3% (n = 8) for a hands-off sex offense and one for a nonsexual violent offense. When applying a broad definition of recidivism, which included ongoing investigations, charges and convictions, 3% (n = 7) of the study sample recidivated with a violent and/or sex offense, 3.9% (n = 9) with a hands-off sex offense and 0.8% (n = 2) with a hands-on sex offense.


CONCLUSION
Consuming child pornography alone is not a risk factor for committing hands-on sex offenses - at least not for those subjects who had never committed a hands-on sex offense. The majority of the investigated consumers had no previous convictions for hands-on sex offenses. For those offenders, the prognosis for hands-on sex offenses, as well as for recidivism with child pornography, is favorable.
Comprison of canny and sobel edge detection in MRI images

Feature extraction approach in medical magnetic resonance imaging (MRI) is very important in order to perform diagnostic image analysis [1]. Edge detection is one of the way to extract more information from magnetic resonance images. Edge detection reduces the amount of data and filters out useless information, while protecting the important structural properties in an image [2]. In this paper, we compare Sobel and Canny edge detection method. In order to compare between them, one slice of MRI image tested with both method. Both method of the edge detection operators are implemented with convolution masks. Sobel method with 3x3 masks while canny used adjustable mask. Those masks will determine the quality of the edge. Edges areas represent a strong intensity contrast which is darker or brighter. Keyword: MRI, Edge detection, Canny method
Mobile Web 2.0 with multi-display buttons

Introduction
 User-Generated Content (UGC) IS A BURGEONING social phenomenon being watched in today's world with keen interest. UGC is an online new-media content created by users rather than by conventional media such as broadcasters. A typical example would be Flickr, an online photo-sharing site with 37 million images, to which its 1.2 million members add up to 200,000 images daily. UGC is shifting the paradigm of Internet use away from the one-way propagation of media content by companies towards the creation and sharing of media content by and among ordinary users.
 The mobile phone is an especially important means of promoting user generation and exchange of media content. Many mobile phones now have built-in digital cameras and inherent network connectivity. These features have greatly facilitated the creation and sharing of media content. For instance, users can immediately upload photos on Flickr with their mobile phones as well as access Flickr and browse other people's media content.
 However, the constraints of a typical mobile phone---its small display and limited number of buttons---make use of mobile UGC services challenging. Only a few studies have investigated hardware or software alternatives to address these problems. This article presents a new user interface (UI) for mobile phones, one that makes use of UGC services easier and more efficient.
 The new interface has two key characteristics: one pertaining to content structure, and another to content visualization. More specifically, the new UI employs two major mobile Web 2.0 technologies, the tag and the tag cloud, and multi-display buttons increase the display size and flexibility of individual buttons. The interface is dedicated specifically towards supporting exploratory browsing within mobile UGC services, because users of such services are likely to focus on exploratory browsing and serendipitous discovery and be more inclined toward entertainment rather than utility. Here, we describe the new interface and investigate whether it aids in enhancing exploratory browsing within mobile UGC services.
Aiding Pronoun Translation with Co-Reference Resolution

We propose a method to improve the translation of pronouns by resolving their coreference to prior mentions. We report results using two different co-reference resolution methods and point to remaining challenges.