LLukas22/scidocs huggingface dataset:
Case Report of S1Q3T3 Electrocardiographic Abnormality in a Pregnant Asthmatic Patient During Acute Bronchospasm

BACKGROUND Asthma is the most common chronic pulmonary disease during pregnancy. Several previous reports have documented reversible electrocardiographic changes during severe acute asthma attacks, including tachycardia, P pulmonale, right bundle branch block, right axis deviation, and ST segment and T wave abnormalities. CASE REPORT We present the case of a pregnant patient with asthma exacerbation in which acute bronchospasm caused S1Q3T3 abnormality on an electrocardiogram (ECG). The complete workup of ECG findings of S1Q3T3 was negative and correlated with bronchospasm. The S1Q3T3 electrocardiographic abnormality can be seen in acute bronchospasm in pregnant women. The other causes like pulmonary embolism, pneumothorax, acute lung disease, cor pulmonale, and left posterior fascicular block were excluded. CONCLUSIONS Asthma exacerbations are of considerable concern during pregnancy due to their adverse effect on the fetus, and optimization of asthma treatment during pregnancy is vital for achieving good outcomes. Prompt recognition of electrocardiographic abnormality and early treatment can prevent adverse perinatal outcomes.
Inventory systems for deteriorating items with shortages and a linear trend in demand-taking account of time value

This paper derives an inventory model for deteriorating items with the demand of linear trend and shortages during the "nite planning horizon considering the time value of money. A simple solution algorithm using a line search is presented to determine the optimal interval which has positive inventories. Numerical examples are given to explain the solution algorithm. Sensitivity analysis is performed to study the e!ect of changes in the system parameters. 2001 Elsevier Science Ltd. All rights reserved.
Prostate-specific antigen and free prostate-specific antigen in the early detection of prostate cancer: do combination tests improve detection?

BACKGROUND
The combined use of free and total prostate-specific antigen (PSA) in early detection of prostate cancer has been controversial. This article systematically evaluates the discriminating capacity of a large number of combination tests.


METHODS
Free and total PSA were analyzed in stored serum samples taken prior to diagnosis in 429 cases and 1,640 controls from the Physicians' Health Study. We used a classification algorithm called logic regression to search for clinically useful tests combining total and percent free PSA and receiver operating characteristic analysis and compared these tests with those based on total and complexed PSA. Data were divided into training and test subsets. For robustness, we considered 35 test-train splits of the original data and computed receiver operating characteristic curves for each test data set.


RESULTS
The average area under the receiver operating characteristic curve across test data sets was 0.74 for total PSA and 0.76 for the combination tests. Combination tests with higher sensitivity and specificity than PSA > 4.0 ng/mL were identified 29 out of 35 times. All these tests extended the PSA reflex range to below 4.0 ng/mL. Receiver operating characteristic curve analysis indicated that the overall diagnostic performance as expressed by the area under the curve did not differ significantly for the different tests.


CONCLUSIONS
Tests combining total and percent free PSA show modest overall improvements over total PSA. However, utilization of percent free PSA below a PSA threshold of 4 ng/mL could translate into a practically important reduction in unnecessary biopsies without sacrificing cancers detected.
Optimal tuning of PI controller for speed control of DC motor drive using particle swarm optimization

This paper present a method to determine the optimal tuning of the PI controller parameter on Direct current (DC) motor drive system using particle swarm optimization (PSO) algorithm, Ziegler-Nichols (ZN) tuning and Modified Ziegler-Nichols (MZN) tuning method. The main objective of this paper is to minimize transient response specifications chosen as rise time, settling time and overshoot, for better speed response of DC motor drive. The speed control of DC motor is done using PI and PID controllers. Implementation of PID controller for DC motor speed control is done using ZN and MZN tuning method. For PSO algorithm technique, PI controller is used to improve the performance of DC motor speed control system. A comparison is made on the basis of objective function (rise time, settling time and overshoot) from output Step responses. The proposed approach had superior features, including easy implementation, stable convergence characteristic, and good computational efficiency. Fast tuning of optimum PI controller parameters yields high-quality solution. Compared with traditional ZN method and MZN method, the proposed method is found indeed more efficient and robust in improving the step response of DC motor drive system.
Sensory augmentation of stiffness using fingerpad skin stretch

When interacting with everyday objects, we experience kinesthetic force feedback as well as various forms of cutaneous tactile feed-back. Skin stretch is part of the cutaneous tactile experience that is caused by friction between the skin and the grasped object. Interacting with stiffer objects causes larger force, and results in a larger amount of skin stretch. Therefore, we hypothesize that adding artificial fingerpad skin stretch to kinesthetic force feedback will increase users' perception of stiffness. A tactile display called the Skin Stretch Stylus was designed to augment kinesthetic force feedback with skin stretch feedback. The change in users' stiffness perception due to the addition of skin stretch feedback is quantified through a two-alternative forced-choice paradigm, method of constant stimuli experiment. In this experiment, subjects compared the stiffness of virtual springs with kinesthetic force feedback augmented with skin stretch feedback versus virtual springs with only kinesthetic force feedback. Results show that the addition of skin stretch causes a significant increase in the perception of stiffness, and this effect increases with higher amount of applied skin stretch. These results indicate that skin stretch feedback could be used to augment perceived stiffness in situations where it is not possible to increase force feedback gains. Such scenarios include teleoperation systems where force feedback gains must remain low to ensure stability, and haptic devices with limited actuator force.
Reasons and risk factors for culling of Holstein dairy cows in Morocco

This study was carried out in a commercial herd from 2008 to 2012 in order to determine the most prevalent reasons for culling Holstein cows and to assess the effects of risk factors. Overall, 519 (28.2%) cows were culled for involuntary (98.8%) and voluntary (1.2%) reasons. The involuntary causes of culling were diseases (38.7%), reproduction problems (36.0%), udder disorders (7.7%), lameness (3.7%) and death (12.7%). Mean age of cows at culling was 70.5±15.6 months and the time interval from last calving to culling averaged 263±196 days. Logistic binary regression was used to model the hazard of culling. The analysis of risk factors showed that parity, calving season, and age at first calving had significant effects on the hazard of culling (P < 0.05 to P <0.001). Thus, cows at parity 3 and 4 or greater had a 116.5% and 253.8% risk of culling, respectively than cows at parity 1 (reference class) (P < 0.001). Cows that calved from May to August and from September to December had a 19.7% and 45.5% risk of culling, respectively, higher than those that calved from January to April. The risk of culling increased with increasing age at first calving. Thus, cows having an age at first calving of 25-30 and 31-38 months had a 130.8% and 90.4% risk of culling, respectively, higher than cows having an age at first calving less or equal than 24 months. It was concluded that identifying reasons for culling can be helpful in determining management problems in dairy herds.
Correlations between Terasaki's HLA class I epitopes and HLAMatchmaker-defined eplets on HLA-A, -B and -C antigens.

Although the determination of human leukocyte antigen (HLA) antibody specificity has traditionally been directed toward HLA antigens, there is now increasing attention to structurally defined HLA epitopes. An understanding of the HLA epitope repertoire is important to acceptable mismatching for sensitized patients and to a new epitope-based matching algorithm aimed to reduce antibody-mediated rejection. There are two strategies to determine the HLA epitope repertoire. Terasaki's group has used an empirical method to analyze the reactivity of single allele Luminex panels with mouse monoclonal antibodies (mAbs) and absorbed/eluted alloantibodies with a computer program based on shared residues in the amino acid sequences of reactive alleles. HLAMatchmaker is a theoretical algorithm that predicts HLA epitopes on the HLA molecular surface from stereochemical modeling of epitope-paratope interfaces of antigen-antibody complexes. Our epitope repertoire is based on so-called 'eplets' representing 3-A patches of at least one polymorphic residue on the molecular surface. A comparative analysis has shown that 81/103 Terasaki's HLA class I epitopes are equivalent to individual eplets (n = 50) or pairs of eplets (n = 31) separated far enough to serve as potential contact sites for two complementarity-determining regions of antibody. An additional 12 Terasaki's epitopes (TerEps) correspond to eplets with permissible residue combinations that do not seem to affect epitope specificity. We could not identify corresponding eplets for the remaining 10 TerEps, including 8 that might be considered xeno-epitopes defined by mouse mAbs. Conversely, HLAMatchmaker has 38 additional eplets in well-exposed surface positions that do not have equivalent TerEps, and for many of them, we have found specific antibodies. These findings strengthen the concept that eplets are essential basic units of HLA epitopes and that they provide a better understanding of HLA immunogenicity (i.e. ability to induce an antibody response) and antigenicity (i.e. reactivity with specific antibody).
PReS-FINAL-2159: Tocilizumab (TCZ) dosing in juvenile idiopathic arthritis (JIA): optimising for different JIA type and body weight patients

Introduction TCZ, an IL-6R inhibitor, is effective in systemic and polyarticular juvenile idiopathic arthritis (sjia, pjia). BWadjusted, intravenous dosing regimens (TCZ8 mg/kg Q2W for sjia and Q4W for pjia) were assessed in Japanese phase 3 trials. As shown in Results, BW adjustment led to lower TCZ exposure with lower BW; thus, higher doses were proposed for patients (pts) with BW<30 kg in the global TENDER (sjia) and CHERISH (pjia) trials.
Removable partial dentures vs overdentures in children with ectodermal dysplasia: two case reports.

BACKGROUND
Ectodermal dysplasia (ED) represents a disorder group characterised by abnormal development of the ectodermal derivatives. Removable partial dentures (RPD), complete dentures (CD) or overdentures (OD) are most often the treatment of choice for young affected patients. Prosthetic intervention is of utmost importance in the management of ED patients, as it resolves problems associated with functional, aesthetic, and psychological issues, and improves a patient's quality of life. However, few studies present the principles and guidelines that can assist in the decision-making process of the most appropriate removable prosthesis. The purpose of this study was to suggest a simple treatment decision-making algorithm for selecting an effective and individualised rehabilitative treatment plan, considering different parameters.


CASE REPORTS
The cases and treatment of two young ED patients are described and each one was treated with either RPDs or ODs.


FOLLOW-UP
Periodic recalls were employed to manage problems, and monitor the changes associated with occlusion and fit of the prostheses in relation to each patient's growth. Both patients were followed up for more than 2 years and reported significant improvement in their appearance, masticatory function, and social behaviour as a result of the prosthetic rehabilitation.


CONCLUSION
The main factors guiding the decision process towards the choice of an RPD or an OD are the presence of posterior natural teeth, facial aesthetics, lip support, number and size of existing natural teeth, and the occlusal vertical dimension.
Oral pantoprazole for erosive esophagitis: a placebo-controlled, randomized clinical trial

OBJECTIVES:The aim of this dose-response study was to compare the effectiveness of 10 mg, 20 mg, and 40 mg of pantoprazole with that of placebo tablets in the healing and symptom relief of gastroesophageal reflux disease associated with erosive esophagitis, and to determine the optimal dose.METHODS:A total of 603 patients with endoscopically confirmed (Hetzel-Dent scale) erosive esophagitis of grade 2 (64.5%) or grades 3 or 4 (35.3%) were enrolled in a double-blind, multicenter study and randomly assigned to receive pantoprazole (10 mg, 20 mg, or 40 mg) or placebo, administered once daily in the morning, for 4 or 8 wk depending on healing.RESULTS:The healing rates after 4 wk for placebo and pantoprazole 10 mg, 20 mg, and 40 mg/day were 14%, 42%, 55%, and 72%, respectively (p < 0.001 for all doses of pantoprazole vs placebo). Cumulative healing rates after 8 wk for placebo and pantoprazole 10 mg, 20 mg, and 40 mg/day were 33%, 59%, 78%, and 88%, respectively (p < 0.001 for all doses of pantoprazole vs placebo). The 40-mg pantoprazole dose produced greater rates of healing and earlier healing of esophagitis than either the 10- or 20-mg dose, regardless of severity. Pantoprazole, at any dose, was significantly more effective than placebo in relieving reflux symptoms. Patients on pantoprazole 40 mg experienced relief of symptoms on day 1 of treatment. No serious treatment-related adverse events occurred.CONCLUSIONS:Pantoprazole was safe and effective for healing erosive esophagitis and provided rapid symptomatic relief. These results indicate that pantoprazole offers a new option for treatment of erosive esophagitis. Among the three doses studied, the 40-mg dose was the most effective.
Realising evidence-based software engineering

This paper provides an introduction to the papers for the Workshop on Realising Evidence-Based Software Engineering.
Polymorphisms of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 and the blood and salivary ethanol and acetaldehyde concentrations of Japanese alcoholic men.

BACKGROUND
The effects of genetic polymorphism of aldehyde dehydrogenase-2 (ALDH2) on alcohol metabolism are striking in nonalcoholics, and the effects of genetic polymorphism of alcohol dehydrogenase-1B (ADH1B) are modest at most, whereas genetic polymorphisms of both strongly affect the susceptibility to alcoholism and upper aerodigestive tract (UADT) cancer of drinkers.


METHODS
We evaluated associations between ADH1B/ADH1C/ALDH2 genotypes and the blood and salivary ethanol and acetaldehyde levels of 168 Japanese alcoholic men who came to our hospital for the first time in the morning and had been drinking until the day before.


RESULTS
The ethanol levels in their blood and saliva were similar, but the acetaldehyde levels in their saliva were much higher than in their blood, probably because of acetaldehyde production by oral bacteria. Blood and salivary ethanol and acetaldehyde levels were both significantly higher in the subjects with the less active ADH1B*1/*1 genotype than in the ADH1B*2 carriers, but none of the levels differed according to ALDH2 genotype. Significant linkage disequilibrium was detected between the ADH1B and ADH1C genotypes, but ADH1C genotype did not affect the blood or salivary ethanol or acetaldehyde levels. High blood acetaldehyde levels were found even in the active ALDH2*1/*1 alcoholics, which were comparable with the levels of the inactive heterozygous ALDH2*1/*2 alcoholics with less active ADH1B*1/*1. The slope of the increase in blood acetaldehyde level as the blood ethanol level increased was significantly steeper in alcoholics with inactive heterozygous ALDH2*1/*2 plus ADH1B*2 allele than with any other genotype combinations, but the slopes of the increase in salivary acetaldehyde level as the salivary ethanol level increased did not differ between the groups of subjects with any combinations of ALDH2 and ADH1B genotypes.


CONCLUSIONS
The ADH1B/ALDH2 genotype affected the blood and salivary ethanol and acetaldehyde levels of nonabstinent alcoholics in a different manner from nonalcoholics, and clear effects of ADH1B genotype and less clear effects of ALDH2 were observed in the alcoholics. Alterations in alcohol metabolism as a result of alcoholism may modify the gene effects, and these findings provide some clues in regard to associations between the genotypes and the risks of alcoholism and UADT cancer.
Visceral adiposity and the prevalence of hypertension in Japanese Americans.

BACKGROUND
Visceral adiposity is generally considered to play a key role in the metabolic syndrome, including hypertension. The purpose of this study was to evaluate cross-sectionally whether visceral adiposity is associated with prevalence of hypertension independent of other adipose depots and fasting plasma insulin.


METHODS AND RESULTS
Study subjects included 563 Japanese Americans with normal or impaired glucose tolerance or diabetes but not taking oral hypoglycemic medication or insulin at entry. Variables included plasma glucose and insulin measured after an overnight fast and during an oral glucose tolerance test, and abdominal, thoracic, and thigh fat areas by CT. Total fat area (TFA) was calculated as the sum of these fat areas. Hypertension was defined as having a systolic blood pressure > or =140 mm Hg, having a diastolic blood pressure > or =90 mm Hg, or taking antihypertensive medications. Intra-abdominal fat area (IAFA) was associated with a higher prevalence of hypertension. Adjusted odds ratio of hypertension by IAFA was 1.68 for a 1-SD increase (95% CI, 1.20 to 2.37) after adjusting for age, sex, fasting plasma insulin, a nonlinear transformation of 2-hour plasma glucose, and TFA. IAFA remained a significant predictor of prevalence of hypertension even after adjustment for total subcutaneous fat area, abdominal subcutaneous fat area, body mass index, or waist circumference, but no measure of regional or total adiposity was associated with the odds of prevalence of hypertension in models that contained IAFA.


CONCLUSIONS
Greater visceral adiposity increases the odds of hypertension in Japanese Americans independent of other adipose depots and fasting plasma insulin.
Numerical modeling and simulation of pile in liquefiable soil

Presented in this paper is numerical methodology to model an d simulate behavior of piles in liquefiable soils. Modeling relies on use of valid te elasto-plastic material model for soil skeleton, verified fully coupled porous media (soil skeleton) – pore fluid (water) dynamic finite element formulation, and detailed lo ad staging of FEM models. A bounding surface elastic–plastic sand model that account s for fabric change is used to model soil skeleton, while a fully coupled, dynamic, inel astic formulation (u-p-U) is used to model soil and water displacement and pore water pres sures. Much attention is paid to accurate staged loading of the models, which start from a zero state of stress and strain for a soil without a pile, followed by applicationf self weight, then by excavation and pile installation with application of pile s lf-weighting. Finally, seismic loading is applied followed by time to dissipate excess p ore pressures that have developed. A total of six cases were modeled and simulated va rying slope inclination, presence of pile–column and boundary condition for pile–co lumn system. Presented are interesting and useful results that are used to deepen ou r understanding of behavior of soil–pile–column systems during liquefaction (late r l deformations, pile pinning effect, ground settlement). Moreover, detailed description o f m deling is used to emphasize the availability and use of high fidelity modeling to ols for simulating effects of liquefied soil on soil–structure systems.
French multicenter experience with the GORE TIGRIS Vascular Stent in superficial femoral and popliteal arteries.

BACKGROUND
Preliminary results in small single-center studies after stenting with the GORE TIGRIS Vascular Stent (W. L. Gore & Associates, Flagstaff, Ariz) show promising short-term primary patency rates, but larger, multicenter studies are needed. This study therefore investigated the performance of the GORE TIGRIS Vascular Stent at three different centers in France in patients with symptomatic peripheral artery disease.


METHODS
This retrospective, single-arm, multicenter cohort study included 215 patients with peripheral artery disease (Rutherford-Becker category 2-6) who were treated with the GORE TIGRIS Vascular Stent, a dual-component stent consisting of a nitinol wire frame combined with a fluoropolymer-interconnecting structure. The efficacy end point was primary patency defined by freedom from binary restenosis as derived by duplex ultrasound imaging until 2 years after the intervention. Primary, secondary, and primary assisted patency rates at 3, 6, 12, 18, and 24 months were estimated by Kaplan-Meier analysis.


RESULTS
The GORE TIGRIS Vascular Stent was used to successfully treat 239 lesions, of which 141 lesions were located in the superficial femoral artery and 98 in the popliteal artery. Patients were a mean age of 74 ± 12 years. Mean lesion length was 86.8 ± 44.7 mm. After 12 and 24 months, the overall primary patency rates were 81.5% and 67.2%, respectively, and primary assisted patency was 94.9% and 84.8%. Secondary patency was achieved in 99.1% at 24 months.


CONCLUSIONS
Our multicenter experience with the GORE TIGRIS Vascular Stent demonstrates continued good results at 2 years for endovascular treatment of challenging obstructive superficial femoral artery and popliteal artery disease.
Reliability, validity and factor structure of the GDS-15 in Iranian elderly.

OBJECTIVES
Depressive disorders are a public health problem even in developing countries. Access to valid and reliable screening instruments is needed for conducting community surveys. The main objective of this study is to provide the Iranian version of the Geriatric Depression Scale-15 (GDS).


METHODS
The GDS-15 Farsi version was developed by translation and back translation. Two hundred and four subjects aged 59 years or older, who were chosen randomly from residents of the Ekbatan district of Tehran, the capital city of Iran, completed the GDS-15. The Composite International Diagnostic Interview (CIDI) was used to establish a gold standard diagnosis of major depressive disorders.


RESULTS
The GDS was found to be an internally consistent measure. Alpha, split-half coefficients and test-retest reliability were 0.9, 0.89 and 0.58 respectively. Two factors were extracted by using factor analysis and the principle component analysis (varimax rotation): 'depression' and 'psychosocial activity'. The Depression factor (omitting items 2, 9, 10, 13), which could be considered as a short form of the scale (alpha = 0.92), has significant correlation with the main scale (r = 0.58). Using receiver operating curve (ROC) analysis, the optimum cutoff score for GDS-15 is 7/8, yielding a sensitivity of 0.9 and a specificity of 0.84. The optimum cutoff score for GDS-11 is 6, yielding a sensitivity of 0.9 and a specificity of 0.83.


CONCLUSION
The long and short forms of the GDS have excellent properties as screening instruments for major depression in older dwellers in Iran, particularly in urban areas, as presented in our findings.