LLukas22/scidocs huggingface dataset:
Effects of low dose versus conventional dose thiazide diuretic on insulin action in essential hypertension.

OBJECTIVE
To see whether low dose thiazide diuretics given to patients with essential hypertension might avoid the adverse metabolic consequences seen with conventional doses.


DESIGN
Double blind randomised crossover study of two 12 week treatment periods with either low dose (1.25 mg) or conventional dose (5.0 mg) bendrofluazide given after a six week placebo run in period.


SETTING
Outpatient clinics serving the greater Belfast area.


SUBJECTS
16 white non-diabetic patients (9 male) under 65 with essential hypertension recruited from general practices within the greater Belfast area.


MAIN OUTCOME MEASURES
Systolic and diastolic blood pressure and peripheral and hepatic insulin action.


RESULTS
One man failed to complete the study. There were no differences between doses in their effects on systolic and diastolic blood pressure. Bendrofluazide 1.25 mg had substantially less effect on serum potassium concentration than the 5.0 mg dose. There were no intertreatment differences in fasting glucose, insulin, cholesterol, and triglyceride concentrations. Bendrofluazide 5.0 mg significantly increased postabsorptive endogenous glucose production compared with baseline (mean 10.9 (SD 1.2) v 10.0 (0.8) mumol/kg/min), whereas bendrofluazide 1.25 mg did not. Postabsorptive endogenous glucose production was significantly higher with bendrofluazide 5.0 mg compared with 1.25 mg (10.9 (1.2) v 9.9 (0.8) mumol/kg/min) but was suppressed to a similar extent after insulin (bendrofluazide 5.0 mg 2.8 (1.5) mumol/kg/min v bendrofluazide 1.25 mg 2.2 (1.5) mumol/kg/min). Exogenous glucose infusion rates required to maintain euglycaemia were not significantly different between doses and were similar to baseline.


CONCLUSIONS
Bendrofluazide 1.25 mg is as effective as conventional doses but has less adverse metabolic effect. In contrast with conventional doses, low dose bendrofluazide has no effect on hepatic insulin action. There is no difference between low and conventional doses of bendrofluazide in their effect on peripheral insulin sensitivity.
Smart gas cylinder: Leakage alert and automatic booking

Now a days, world is very fast and automate due to change in technologies. Internet of things is one of the important technologies which operate hardware resources remotely. This project deals with automatic booking of gas Cylinder and also detects leakage of gas. In our home, we observe whenever the LPG cylinder is get empty, we need to give request to the gas cylinder provider for new cylinder. However, many times it happens that because of the rush or due to the shortage of the cylinder, there is a delay in providing the gas cylinder. The main reason behind this is the delay in informing to the gas provider or we inform the gas provider at the last moment when the gas is empty. This project also detects the leakage of gas from LPG cylinder using gas sensor which is very sensitive to detect presence of LPG (composed of mostly butane and propane). To avoid all such situations, we have proposed solution through this paper.
Effect of increased warfarin use on warfarin-related cerebral hemorrhage: a longitudinal population-based study.

BACKGROUND AND PURPOSE
Warfarin use has rapidly increased with the aging of the population. We investigated the temporal trends in the incidence and outcome of warfarin-related intracerebral hemorrhages (ICHs) in a defined population.


METHODS
We identified all subjects with first-ever primary ICH during 1993 to 2008 among the population of Northern Ostrobothnia, Finland. The number of warfarin users was obtained from the national register of prescribed medicines kept by the Social Insurance Institution of Finland. We calculated the annual incidence of warfarin-related ICHs, 28-day case fatality, and deaths from the primary bleed.


RESULTS
The proportion of warfarin users among the population increased 3.6-fold from 0.68% in 1993 to 2.28% in 2008. Of a total of 982 patients with ICH, 182 (18.5%) had warfarin-related ICH. One-year survival rate after onset of stroke was 35.2% among warfarin users and 67.9% among nonusers. The annual incidence (P=0.062) and 28-day case fatality of warfarin-related ICHs (P=0.002) decreased during the observation period. Warfarin users were older (mean difference 6.6; 95% CI, 5.0 to 8.1; P<0.001) than nonusers. Admission international normalized ratio values above the therapeutic range (2.0 to 3.0) decreased through the observation period, suggesting improved control of anticoagulant therapy over time.


CONCLUSIONS
The annual incidence and case fatality of warfarin-related ICHs decreased, although the proportion of warfarin users almost quadrupled in our population.
MCS Selection for Throughput Improvement in Downlink LTE Systems

In this paper, we investigate resource block (RB) assignment and modulation-and-coding scheme (MCS) selection to maximize downlink throughput of long-term evolution (LTE) systems, where all RB's assigned to the same user in any given transmission time interval (TTI) must use the same MCS. We develop several effective MCS selection schemes by using the effective packet-level SINR based on exponential effective SINR mapping (EESM), arithmetic mean, geometric mean, and harmonic mean. From both analysis and simulation results, we show that the system throughput of all the proposed schemes are better than that of the scheme in [7]. Furthermore, the MCS selection scheme using harmonic mean based effective packet-level SINR almost reaches the optimal performance and significantly outperforms the other proposed schemes.
The effectiveness of aerobic training, cognitive behavioural therapy, and energy conservation management in treating MS-related fatigue: the design of the TREFAMS-ACE programme

BACKGROUND
TREFAMS is an acronym for TReating FAtigue in Multiple Sclerosis, while ACE refers to the rehabilitation treatment methods under study, that is, Aerobic training, Cognitive behavioural therapy, and Energy conservation management. The TREFAMS-ACE research programme consists of four studies and has two main objectives: (1) to assess the effectiveness of three different rehabilitation treatment strategies in reducing fatigue and improving societal participation in patients with MS; and (2) to study the neurobiological mechanisms of action that underlie treatment effects and MS-related fatigue in general.


METHODS/DESIGN
Ambulatory patients (n = 270) suffering from MS-related fatigue will be recruited to three single-blinded randomised clinical trials (RCTs). In each RCT, 90 patients will be randomly allocated to the trial-specific intervention or to a low-intensity intervention that is the same for all RCTs. This low-intensity intervention consists of three individual consultations with a specialised MS-nurse. The trial-specific interventions are Aerobic Training, Cognitive Behavioural Therapy, and Energy Conservation Management. These interventions consist of 12 individual therapist-supervised sessions with additional intervention-specific home exercises. The therapy period lasts 16 weeks. All RCTs have the same design and the same primary outcome measures: fatigue - measured with the Checklist Individual Strength, and participation - measured with the Impact on Participation and Autonomy questionnaire. Outcomes will be assessed 1 week prior to, and at 0, 8, 16, 26 and 52 weeks after randomisation. The assessors will be blinded to allocation. Pro- and anti-inflammatory cytokines in serum, salivary cortisol, physical fitness, physical activity, coping, self-efficacy, illness cognitions and other determinants will be longitudinally measured in order to study the neurobiological mechanisms of action.


DISCUSSION
The TREFAMS-ACE programme is unique in its aim to assess the effectiveness of three rehabilitation treatments. The programme will provide important insights regarding the most effective treatment for MS-related fatigue and the mechanisms that underlie treatment response. A major strength of the programme is that the design involves three almost identical RCTs, enabling a close comparison of the treatment strategies and a strong overall meta-analysis. The results will also support clinical practice guidelines for the treatment of MS-related fatigue.


TRIAL REGISTRATIONS
Current Controlled Trials ISRCTN69520623, ISRCTN58583714, and ISRCTN82353628.
Aspirin versus low-molecular-weight heparin for extended venous thromboembolism prophylaxis after total hip arthroplasty: a randomized trial.

BACKGROUND
The role of aspirin in thromboprophylaxis after total hip arthroplasty (THA) is controversial.


OBJECTIVE
To compare extended prophylaxis with aspirin and dalteparin for prevention of symptomatic venous thromboembolism (VTE) after THA.


DESIGN
Multicenter randomized, controlled trial with a noninferiority design based on a minimal clinically important difference of 2.0%. Randomization was electronically generated; patients were assigned to a treatment group through a Web-based program. Patients, physicians, study coordinators, health care team members, outcome adjudicators, and data analysts were blinded to interventions. (Current Controlled Trials: ISRCTN11902170).


SETTING
12 tertiary care orthopedic referral centers in Canada.


PATIENTS
778 patients who had elective unilateral THA between 2007 and 2010.


INTERVENTION
After an initial 10 days of dalteparin prophylaxis after elective THA, patients were randomly assigned to 28 days of dalteparin (n = 400) or aspirin (n = 386).


MEASUREMENTS
Symptomatic VTE confirmed by objective testing (primary efficacy outcome) and bleeding.


RESULTS
Five of 398 patients (1.3%) randomly assigned to dalteparin and 1 of 380 (0.3%) randomly assigned to aspirin had VTE (absolute difference, 1.0 percentage point [95% CI, -0.5 to 2.5 percentage points]). Aspirin was noninferior (P < 0.001) but not superior (P = 0.22) to dalteparin. Clinically significant bleeding occurred in 5 patients (1.3%) receiving dalteparin and 2 (0.5%) receiving aspirin. The absolute between-group difference in a composite of all VTE and clinically significant bleeding events was 1.7 percentage points (CI, -0.3 to 3.8 percentage points; P = 0.091) in favor of aspirin.


LIMITATION
The study was halted prematurely because of difficulty with patient recruitment.


CONCLUSION
Extended prophylaxis for 28 days with aspirin was noninferior to and as safe as dalteparin for the prevention of VTE after THA in patients who initially received dalteparin for 10 days. Given its low cost and greater convenience, aspirin may be considered a reasonable alternative for extended thromboprophylaxis after THA.


PRIMARY FUNDING SOURCE
Canadian Institutes of Health Research.
Treatment optimization and prediction of HCV clearance in patients with acute HCV infection.

BACKGROUND & AIMS
The lack of consensus on the optimal timing, regimen, and duration of treatment, in patients with acute HCV infection, stimulates the research on both favourable outcome predictors and individualized treatment regimens. This study aimed at investigating the impact of IL28B SNP rs12979860 alone or in combination with HLA class II alleles in both predicting spontaneous viral clearance and individualizing treatment strategies for patients with HCV persistence, after acute HCV exposure.


METHODS
178 patients with AHC, consecutively treated with interferon alone or in combination with ribavirin, starting within or after 48 weeks from the diagnosis of AHC, were tested for IL28B SNPs and HLA class II alleles.


RESULTS
Spontaneous viral clearance was achieved in 28% of 169 patients available for genetic testing. Factors associated with HCV elimination were jaundice (OR 2.75, 95% CI 1.31-5.77) and IL28B CC (OR 3.87, CI 1.71-8.51), but not HLA alleles. In CT/TT patients without jaundice, NPV for virus persistence was 98%. In patients with IL28B CT/TT, starting treatment 48 weeks after the onset was significantly associated with lower rates of response (28% vs. 100%, p=0.027). By contrast, no significant differences in the rate of SVR were observed for CC carriers who started treatment later (65% vs. 85%, p=1.0).


CONCLUSIONS
In patients with acute HCV hepatitis, lack of viral clearance may be predicted by absence of jaundice and IL28B CT/TT genotype; in patients with these characteristics, treatment needs to be started immediately.
An annotated catalog of fossil and subfossil Lepidoptera (Insecta: Holometabola) of the world

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Methods and conventions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 A catalog of lepidopteran fossils . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 Fossils securely placed in Lepidoptera . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 Lepidoptera incertae sedis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 84 Putative lepidopteran fossils . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 95 Fossils excluded from Lepidoptera . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 98 Acknowledgments . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 102 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 102 Taxon index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 117 Author index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 123
The PI3K/Akt/mTOR signaling pathway mediates insulin-like growth factor 1-induced E-cadherin down-regulation and cell proliferation in ovarian cancer cells.

Insulin-like growth factor 1 (IGF1) is produced by ovarian cancer cells and it has been suggested that it plays an important role in tumor progression. In this study, we report that IGF1 treatment down-regulated E-cadherin by up-regulating E-cadherin transcriptional repressors, Snail and Slug, in human ovarian cancer cells. The pharmacological inhibition of phosphatidylinositol-3-kinase (PI3K) and mammalian target of rapamycin (mTOR) suggests that PI3K/Akt/mTOR signaling is required for IGF1-induced E-cadherin down-regulation. Moreover, IGF1 up-regulated Snail and Slug expression via the PI3K/Akt/mTOR signaling pathway. Finally, IGF1-induced cell proliferation was abolished by inhibiting PI3K/Akt/mTOR signaling. This study demonstrates a novel mechanism in which IGF1 down-regulates E-cadherin expression through the activation of PI3K/Akt/mTOR signaling and the up-regulation of Snail and Slug in human ovarian cancer cells.
Computational modeling of deformation bands in granular media . I . Geological and mathematical framework

Failure of granular media under natural and laboratory loading conditions involves a variety of micromechanical processes producing several geometrically, kinematically, and texturally distinct types of structures. This paper provides a geological framework for failure processes as well as a mathematical model to analyze these processes. Of particular interest is the formation of tabular deformation bands in granular rocks, which could exhibit distinct localized deformation features including simple shearing, pure compaction/dilation, and various possible combinations thereof. The analysis is carried out using classical bifurcation theory combined with non-linear continuum mechanics and theoretical/computational plasticity. For granular media, yielding and plastic flow are known to be influenced by all three stress invariants, and thus we formulate a family of three-invariant plasticity models with a compression cap to capture the entire spectrum of yielding of geomaterials. We then utilize a return mapping algorithm in principal stress directions to integrate the stresses over discrete load increments, allowing the solution to find the critical bifurcation point for a given loading path. The formulation covers both the infinitesimal and finite deformation regimes, and comparisons are made of the localization criteria in the two regimes. In the accompanying paper, we demonstrate with numerical examples the role that the constitutive model and finite deformation effects play on the prediction of the onset of deformation bands in geomaterials. 2004 Elsevier B.V. All rights reserved.
Viewing Angle Classification of Cryo-Electron Microscopy Images Using Eigenvectors

The cryo-electron microscopy (cryo-EM) reconstruction problem is to find the three-dimensional structure of a macromolecule given noisy versions of its two-dimensional projection images at unknown random directions. We introduce a new algorithm for identifying noisy cryo-EM images of nearby viewing angles. This identification is an important first step in three-dimensional structure determination of macromolecules from cryo-EM, because once identified, these images can be rotationally aligned and averaged to produce "class averages" of better quality. The main advantage of our algorithm is its extreme robustness to noise. The algorithm is also very efficient in terms of running time and memory requirements, because it is based on the computation of the top few eigenvectors of a specially designed sparse Hermitian matrix. These advantages are demonstrated in numerous numerical experiments.
Autonomous and autonomic systems: a paradigm for future space exploration missions

More and more, the National Aeronautics and Space Administration (NASA) will rely on concepts from autonomous systems not only in mission control centers on the ground, but also on spacecraft and on rovers and other space assets on extraterrestrial bodies. Autonomy facilitates not only reduced operations costs, but also adaptable goal-driven functionality of mission systems. Space missions lacking autonomy will be unable to achieve the full range of advanced mission objectives, given that human control under dynamic environmental conditions will not be feasible due, in part, to the unavoidably high signal propagation latency and constrained data rates of mission communications links. While autonomy supports cost-effective accomplishment of mission goals, autonomicity supports survivability of remote mission assets, especially when tending by humans is not feasible. In principle, the properties of autonomic systems may enable space missions of a higher order than any previously flown. Analysis of two NASA agent-based systems previously prototyped, and of a proposed future mission involving numerous cooperating spacecraft, illustrates how autonomous and autonomic system concepts may be brought to bear on future space missions
Three-dimensional structure of magnetic field in the mixed-/spl mu/ levitation system using bulk superconductors

A permanent-magnet type mixed-/spl mu/ levitation system, which only needs an iron, permanent magnets and bulk superconductors, can realize an advantageous levitation system-for example, for transportation over a relatively long distance because of its simple structure and stable levitation without active control. A three-dimensional numerical analysis of electromagnetic force characteristics in the mixed-/spl mu/ levitation system is carried out and the results of the analysis are compared with experiments. From these results, the authors have confirmed that the three-dimensional structure of the magnetic field and the electromagnetic performance of superconductors strongly influence the characteristics of the electromagnetic force acting on the iron, which become unstable in some cases.
Fast Marching farthest point sampling for point clouds and implicit surfaces

In a recent paper [13], the Fast Marching farthest point sampling strategy (FastFPS) for planar domains and curved manifolds was introduced. The version of FastFPS for curved manifolds discussed in the paper [13] deals with surface domains in triangulated form only. Due to a restriction of the underlying Fast Marching method, the algorithm further requires the splitting of any obtuse into acute triangles to ensure the consistency of the Fast Marching approximation. In this paper, we overcome these restrictions by using Mémoli and Sapiro’s [11, 12] extension of the Fast Marching method to the handling of implicit surfaces and point clouds. We find that the extended FastFPS algorithm can be applied to surfaces in implicit or point cloud form without the loss of the original algorithm’s computational optimality and without the need for any preprocessing.
Tax Evasion across Industries: Soft Credit Evidence from Greece

We begin with the new observation that banks lend to tax-evading individuals based on the bank's perception of true income. This insight leads to a novel approach to estimate tax evasion from privatesector adaptation to semiformality. We use household microdata from a large bank in Greece and replicate bank models of credit capacity, credit card limits, and mortgage payments to infer the bank’s estimate of individuals’ true income. We estimate a lower bound of 28 billion euros of unreported income for Greece. The foregone government revenues amount to 31 percent of the deficit for 2009. Primary taxevading occupations are doctors, engineers, private tutors, accountants, financial service agents, and lawyers. Testing the industry distribution against a number of redistribution and incentive theories, our evidence suggests that industries with low paper trail and industries supported by parliamentarians have more tax evasion. We conclude by commenting on the property right of informal income. *Corresponding Authors: Adair Morse; email: adair.morse@chicagobooth.edu. Margarita Tsoutsoura; email: tsoutsoura@chicagobooth.edu. We are grateful for helpful comments to Loukas Karabarbounis, Amit Seru, Annette VissingJorgensen, Luigi Zingales, and seminar participants at Chicago Booth, Berkeley Haas, INSEAD, Catholica Lisbon School of Business, London Business School, NOVA School of Business, UBC, NBER Public Economic meeting, Booth-Deutschebank Symposium and the Political Economy in the Chicago area conference. This research was funded in part by the Fama-Miller Center for Research in Finance, the Polsky Center for Entrepreneurship at the University of Chicago, Booth School of Business, and the Goult Faculty Research Endowment. Tsoutsoura gratefully acknowledges financial support from the PCL Faculty Research Fund at the University of Chicago, Booth School of Business