LLukas22/scidocs huggingface dataset:
In Vivo quantitative imaging of angiogenesis-targeted PFOB nanoparticles in a hypercholesterol rabbit model using 19F-MRI with ultra-short echo time balanced SSFP

Background aνb3-integrin targeted nanoparticle (NP) emulsions have been shown to detect and quantify angiogenesis and anti-angiogenic therapy in small animal models of atherosclerosis. While these NP were visualized in high resolution preand post-injection H-MRI via a Gadolinium (Gd) chelate, we seek to image the perfluoro-octyl bromide (PFOB) core directly via F MR. Early in vivo successes of F MR molecular imaging exploited the single resonance peak of perfluoro-crown-ether. However, PFOB, which is the more clinically-relevant NP with a better-understood human safety profile, has a more complex spectrum with seven F resonance peaks and multiple relaxation conditions, leading to chemical shift artifact and intra-voxel destructive interference. We hypothesize that a new technique—simultaneous dualfrequency F/H ultra-short echo time (UTE) balanced steady state free precession (b-SSFP) sequence with 3D radial readout—will allow efficient, sensitive imaging of the complex PFOB signal without the need for Gd and in sufficient resolution to discern the anatomy even in the presence of cardiac and respiratory motion.
Enhancing learning systems by using virtual interactive classrooms and web-based collaborative work

There are many e-learning web sites and e-learning systems that are available with excellent content and design but they generally lack interactive response and face-to-face communication. Students cannot ask questions and get responses immediately. It is similar to one way communication for learning. However, learning is most effective when it actively constructs knowledge during group social interaction and collaboration. Therefore, this paper proposes to inspire creativity in e-learning called the virtual interactive classroom by using RTMP (RealTime Messaging Protocol) which is a sophisticated TCP-based real-time networking protocol which supports the efficient exchange of messages, synchronized data, audio, and video. Teachers and students can publish streaming audio, video and other data messages to present streaming media with interaction or navigation. Using this virtual classroom on the internet, students can immediately interact with teachers as though they were studying in a real classroom. In addition to the virtual interactive classroom, this article also proposes using web-based collaborative work as an add-on feature to the learning system. Both teacher and student can use web-based collaborative work for sharing resources and exchanging ideas after the class. The integration of the two concepts of the virtual interactive classroom and web-based collaborative work in order to enhance teaching and learning performance has been created.
Stepwise transition from the Eocene greenhouse to the Oligocene icehouse

Department of Earth and Environmental Science, Rensselaer Polytechnic Inst., Troy, New York 12180, USA Department of Earth and Planetary Sciences, Rutgers University, Piscataway, New Jersey 08854, USA Institute of Marine and Coastal Science, Rutgers University, 71 Dudley Road, New Brunswick, New Jersey 08901, USA Department of Geology and Geophysics, Texas A&M University, College Station, Texas 77840, USA Department of Geological Sciences, 1272 University of Oregon, Eugene, Oregon 97403-1272, USA *e-mail: katzm@rpi.edu
Autogynephilia : A Paraphilic Model of Gender Identity Disorder

Autogynephilia is defined as a male’s propensity to be sexually aroused by the thought or image of himself as female. Autogynephilia explains the desire for sex reassignment of some maleto-female (MtF) transsexuals. It can be conceptualized as both a paraphilia and a sexual orientation. The concept of autogynephilia provides an alternative to the traditional model of transsexualism that emphasizes gender identity. Autogynephilia helps explain mid-life MtF gender transition, progression from transvestism to transsexualism, the prevalence of other paraphilias among MtF transsexuals, and late development of sexual interest in male partners. Hormone therapy and sex reassignment surgery can be effective treatments in autogynephilic transsexualism. The concept of autogynephilia can help clinicians better understand MtF transsexual clients who recognize a strong sexual component to their gender dysphoria. (Journal of Gay & Lesbian Psychotherapy, 8(1/2), 2004, pp. 69-87.)
Force Estimation Based Compliance Control of Harmonically Driven Manipulators

The problem of estimating external forces exerted on a robotic manipulator with harmonic drive gearing without a force-torque sensor is considered. Manipulator dynamics together with motor current feedback is used to estimate external joint torques, which are transformed into estimated external end effector forces using knowledge of the manipulator's kinematics. Adaptive control is used to tune the parameters of the robot's modeled dynamics, while adaptive radial basis function (RBF) "neural" networks are used to learn the friction model. Compliance control is implemented on a two degree of freedom manipulator based on the force estimates. Results are compared to compliance control using a six-axis force-torque sensor mounted on the manipulator
[Muscle retraining or aerobic endurance training? What will improve the aerobic capacity of patients with coronary disease in the only 4 weeks?].

OBJECTIVE
The aim of this study was to compare the effects of 4 weeks of CT and AT, which training impulse (total external workload and perceived exertion), are similar on power associated at VO2 peak (pVO2 peak) and cardiorespiratory responses of patient with CAD.


METHOD
Eighteen male with CAD (62 ± 7 years, 175 ± 2 cm, 84 ± 16 kg, fraction of ejection = 0.49 ± 0.16) performed 4 weeks of CT (n = 9) or AT (n = 9). pVO2 peak, maximal and first ventilatory threshold values of oxygen uptake (VO2 peak, VO2-vt) and heart rate (HRmax, HR-vt) were measured before and after training session. Total training impulse (exercise rehabilitation and other paramedical actions) were evaluated and harmonized between AT and CT according to Foster et al. formula (1996) RESULTS: No significant difference were found in training impulse between AT and CT (3650 ± 220 vs 3497 ± 190 U, P = NS). VO2 pic increased after AT (16.9 ± 4.4 vs 18.9 ± 4.9 mL O2/min/kg, P < 0.05) and remained unchanged after CT (17.7 ± 7.8 vs 17.8 ± 7.2, P = NS). Four weeks of training induced significant increase in pVO2 peak, VO2-vt and FC-vt, expressed in absolute or relative value (P < 0,05), without any difference between AT and CT modalities (P = NS).


CONCLUSIONS
Improving pVO2 pic following an exercise training does not necessarily preclude an improvement in coronary VO2 pic. pVO2 peak was not improved with the same cardiorespiratory adaptations between AT and CT. Thus, there seems important to measure gas exchanges of subject with CAD during the incremental test and identify the respective part of muscular and cardiorespiratory functions in exercise exhaustion.
FLUCTUATING JAUNDICE IN THE ADENOCARCINOMA OF THE AMPULLA OF VATER: a classic sign or an exception?

BACKGROUND
Some authors consider the fluctuating jaundice as a classic sign of the adenocarcinoma of the ampulla of Vater.


OBJECTIVE
Assessing the frequency of fluctuating jaundice in their forms of its depiction in the patients with adenocarcinoma of the ampulla of Vater.


METHODS
Observational and retrospective study, conducted through analyses of medical records from patients subjected to pancreatic cephalic resections between February 2008 and July 2013. The pathological examination of the surgical specimen was positive to adenocarcinoma of the ampulla of Vater. Concepts and differences on clinical and laboratory fluctuating jaundice were standardized. It was subdivided into type A and type B laboratory fluctuating jaundice.


RESULTS
Twenty patients were selected. One of them always remained anicteric, 11 patients developed progressive jaundice, 2 of them developed clinical and laboratory fluctuating jaundice, 5 presented only laboratory fluctuating jaundice and one did not present significant variations on total serum bilirubin levels. Among the seven patients with fluctuating jaundice, two were classified as type A, one as type B and four were not classified due to lack information. Finally, progressive jaundice was the prevailing presentation form in these patients (11 cases).


CONCLUSION
This series of cases suggested that clinical fluctuating jaundice is a uncommon signal in adenocarcinoma of the ampulla of Vater.
Proactive and Reactive Violence among Intimate Partner Violent Men Diagnosed with Antisocial and Borderline Personality Disorder

Personality disorder features have been an important basis of many batterer typologies (Babcock et al. J Fam Violence 15:391–409, 2000; Holtzworth-Munroe and Stuart Psychol Bull 116:476–497, 1994), most notably Antisocial and Borderline Personality Disorders. Aggression that partner violent men commit has also been found to be heterogeneous, motivated by the need to control (proactive) or enacted out of emotion (reactive). In the present study, men who were physically abusive towards their female partner (N = 124 couples) were administered the SCID-II diagnostic interview for Antisocial (ASPD) and Borderline Personality Disorder (BPD). It was hypothesized that partner violent men diagnosed with ASPD would show highest levels of proactive violence whereas men diagnosed with BPD (alone or comorbidly with ASPD) were expected to be reactively violent. Results suggest that violence perpetrated by men with different personality disorders differs in its function. Within the context of intimate relationships, BPD/comorbid men appear to use violence more reactively, while ASPD men tend to use violence both proactively and reactively. Implications for treatment are discussed.
Fake News Detection in Social Networks via Crowd Signals

Our work considers leveraging crowd signals for detecting fake news and is motivated by tools recently introduced by Facebook that enable users to flag fake news. By aggregating users’ flags, our goal is to select a small subset of news every day, send them to an expert (e.g., via a third-party fact-checking organization), and stop the spread of news identified as fake by an expert. The main objective of our work is to minimize the spread of misinformation by stopping the propagation of fake news in the network. It is especially challenging to achieve this objective as it requires detecting fake news with high-confidence as quickly as possible. We show that in order to leverage users’ flags efficiently, it is crucial to learn about users’ flagging accuracy. We develop a novel algorithm, Detective, that performs Bayesian inference for detecting fake news and jointly learns about users’ flagging accuracy over time. Our algorithm employs posterior sampling to actively trade off exploitation (selecting news that maximize the objective value at a given epoch) and exploration (selecting news that maximize the value of information towards learning about users’ flagging accuracy). We demonstrate the effectiveness of our approach via extensive experiments and show the power of leveraging community signals for fake news detection. ACM Reference Format: Sebastian Tschiatschek, Adish Singla, Manuel Gomez Rodriguez, Arpit Merchant, andAndreas Krause. 2018. FakeNewsDetection in Social Networks via Crowd Signals. In WWW ’18 Companion: The 2018 Web Conference Companion, April 23–27, 2018, Lyon, France. ACM, New York, NY, USA, 8 pages. https://doi.org/10.1145/3184558.3188722
Abstract 149: Identifying the Psychosocial Needs of New Stroke Patients: A Retrospective Chart Review of Stroke Patients with Previous Psychiatric Diagnosis

Introduction: The patient experience for a newly diagnosed stroke patient can be psychologically devastating. Limited research exists on stroke patients with pre-existing psychiatric conditions, including implications on quality of life, outcomes, readmissions, compliance and utilization of resources. The majority of the research focuses on depression post stroke diagnosis or discharge. Stroke patients are known to be vulnerable to psychological issues after a stroke diagnosis. However, we are limited in understanding how the hospital experience is for new stroke patients with preexisting psychiatric illness including: whether or not sufficient support is being provided during their hospital admission; is the underlying psychiatric illness preventing them from meeting functional milestones; and are they prepared for discharge? Methods: The study design is a retrospective chart review of newly diagnosed stroke patients with a previous psychiatric diagnosis admitted between January to June 2018. Data on soc...
International nursing students and what impacts their clinical learning: literature review.

This paper reviews the sparse literature about international nursing students' clinical learning experiences, and also draws on the literature about international higher education students' learning experiences across disciplines as well as nursing students' experiences when undertaking international clinical placements. The paper aims to identify factors that may impact international nursing students' clinical learning with a view to initiating further research into these students' attributes and how to work with these to enhance the students' clinical learning. Issues commonly cited as affecting international students are socialisation, communication, culture, relationships, and unmet expectations and aspirations. International student attributes tend to be included by implication rather than as part of the literature's focus. The review concludes that recognition and valuing of international nursing students' attributes in academic and clinical contexts are needed to facilitate effective strategies to support their clinical practice in new environments.
Evolving Neural Turing Machines for Reward-based Learning

An unsolved problem in neuroevolution (NE) is to evolve artificial neural networks (ANN) that can store and use information to change their behavior online. While plastic neural networks have shown promise in this context, they have difficulties retaining information over longer periods of time and integrating new information without losing previously acquired skills. Here we build on recent work by Graves et al. [5] who extended the capabilities of an ANN by combining it with an external memory bank trained through gradient descent. In this paper, we introduce an evolvable version of their Neural Turing Machine (NTM) and show that such an approach greatly simplifies the neural model, generalizes better, and does not require accessing the entire memory content at each time-step. The Evolvable Neural Turing Machine (ENTM) is able to solve a simple copy tasks and for the first time, the continuous version of the double T-Maze, a complex reinforcement-like learning problem. In the T-Maze learning task the agent uses the memory bank to display adaptive behavior that normally requires a plastic ANN, thereby suggesting a complementary and effective mechanism for adaptive behavior in NE.
A phase I study of bi-weekly docetaxel for recurrent or advanced gastric cancer patients whose disease progressed by prior chemotherapy.

OBJECTIVE
Although docetaxel is active against gastric cancer, Grade 3 or 4 neutropenia occurs in the majority of patients in Japan when administered at 60 mg/m(2) every 3 weeks. To determine a more convenient and tolerable schedule than the tri-weekly schedule, we conducted a dose-escalation study of bi-weekly docetaxel. In this study, we investigated the maximum-tolerated dose and recommended dose.


METHODS
Patients with advanced gastric cancer who had received prior chemotherapy were enrolled between April 2004 and March 2007. This study was designed to evaluate the escalated dose of docetaxel starting at 35 mg/m(2) (Level 1) given every 2 weeks. The dose was escalated in a stepwise fashion to 40 mg/m(2) (Level 2), 45 mg/m(2) (Level 3) and 50 mg/m(2) (Level 4).


RESULTS
Fifteen patients completed at least two cycles of the therapy. Three episodes of Grade 3 neutropenia occurred in all patients and Grade 4 neutropenia was observed at Level 4 in six patients. Grade 3 or 4 thrombocytopenia and anemia were not observed. Grade 3 aspartate aminotransferase/alanine aminotransferase elevation (n= 1) and Grade 3 stomatitis (n = 1) were noted at Level 4. There was no other Grade 3 or 4 non-hematologic toxicity. The definition of dose-limiting toxicities of this docetaxel schedule at Level 4 are Grade 4 neutropenia, Grade 3 aspartate aminotransferase/alanine aminotransferase elevation and Grade 3 stomatitis.


CONCLUSIONS
The maximum-tolerated dose of docetaxel when administrated following the bi-weekly schedule was 50 mg/m(2) and the recommended dose was 45 mg/m(2). Bi-weekly administration of docetaxel may provide a better tolerated and efficacious use in gastric cancer.
Augmentation Scheme for Fault-Tolerant Control Using Integral Sliding Modes

In this brief paper, a novel fault-tolerant control allocation scheme is proposed that has the capability to maintain closed-loop nominal performance in the case of faults/failures by effectively managing the actuator redundancy, and without reconfiguring the underlying control law. The proposed scheme relies on an a posteri approach, building on an existing state feedback controller designed using only the primary actuators. An ISM scheme is integrated with the existing controller to introduce fault tolerance. The proposed scheme uses the measured or estimated actuator effectiveness levels in order to redistribute the control signals to the healthy ones, which allows a certain class of total actuator failures to be mitigated. The effectiveness of the proposed scheme is tested in simulation using a high-fidelity nonlinear model of a large transport aircraft model.
Acute Intermittent Porphyria in Argentina: An Update

Porphyrias are a group of metabolic diseases that arise from deficiencies in the heme biosynthetic pathway. A partial deficiency in hydroxymethylbilane synthase (HMBS) produces a hepatic disorder named Acute Intermittent Porphyria (AIP); the acute porphyria is more frequent in Argentina. In this paper we review the results obtained for 101 Argentinean AIP families and 6 AIP families from foreign neighbour countries studied at molecular level at Centro de Investigaciones sobre Porfirinas y Porfirias (CIPYP). Thirty-five different mutations were found, of which 14 were described for the first time in our population. The most prevalent type of mutations was the missense mutations (43%) followed by splice defects (26%) and small deletions (20%). An odd case of a double heterozygous presentation of AIP in a foreign family from Paraguay is discussed. Moreover, it can be noted that 38 new families were found carrying the most frequent mutation in Argentina (p.G111R), increasing to 55.66% the prevalence of this genetic change in our population and adding further support to our previous hypothesis of a founder effect for this mutation in Argentina. Identification of patients with an overt AIP is important because treatment depends on an accurate diagnosis, but more critical is the identification of asymptomatic relatives to avoid acute attacks which may progress to death.
Rotterdam computed tomography score as a prognosticator in head-injured patients undergoing decompressive craniectomy.

BACKGROUND
The Rotterdam computed tomography (CT) score was developed for prognostic purposes in traumatic brain injury (TBI).


OBJECTIVE
To examine the prognostic discrimination and prediction of the Rotterdam CT score in the case of patients undergoing decompressive craniectomy (DC) for TBI.


METHODS
The CT scans with the worst findings before DC were scored according to the Rotterdam CT classification. Mortality and Glasgow Outcome Scale score at the end of follow-up were used as outcome measures. Unfavorable and favorable outcomes were defined by a Glasgow Outcome Scale score of 1 to 3 and 4 to 5, respectively. We used binary logistic and proportional odds regression for prognostic analyses.


RESULTS
The relationship between the Rotterdam CT score and prognosis was quantified, and higher scores indicated worse patient outcomes. Univariate analysis showed that the Rotterdam CT score was significantly associated with mortality (odds ratio: 3.117, 95% confidence interval: 1.867-5.386; P < .001) and unfavorable outcomes (odds ratio: 2.612, 95% confidence interval: 1.733-3.939; P < .001). After adjustment for published outcome predictors of TBI in multivariate regression, the Rotterdam CT score remained an independent predictor of unfavorable outcomes (odds ratio: 1.830, 95% confidence interval: 1.043-3.212; P = .035).


CONCLUSION
For head-injured patients undergoing DC, the Rotterdam CT score provides great prognostic discrimination and is an independent predictor of unfavorable outcomes. We suggest that the Rotterdam CT score be included as a prognosticator in the overall assessment of clinical condition of TBI patients before DC.
Understanding barriers to optimal medication management for those requiring long-term dialysis: rationale and design for an observational study, and a quantitative description of study variables and data

BACKGROUND
Rates of medication non-adherence in dialysis patients are high, and improving adherence is likely to improve outcomes. Few data are available regarding factors associated with medication adherence in dialysis patients, and these data are needed to inform effective intervention strategies.


METHODS/DESIGN
This is an observational cross-sectional study of a multi-ethnic dialysis cohort from New Zealand, with the main data collection tool being an interviewer-assisted survey. A total of 100 participants were randomly sampled from a single centre, with selection stratified by ethnicity and dialysis modality (facility versus home). The main outcome measure is self-reported medication adherence using the Morisky 8-Item Medication Adherence Scale (MMAS-8). Study data include demographic, clinical, social and psychometric characteristics, the latter being constructs of health literacy, medication knowledge, beliefs about medications, and illness perceptions. Psychometric constructs were assessed through the following survey instruments; health literacy screening questions, the Medication Knowledge Evaluation Tool (Okuyan et al.), the Beliefs about Medication Questionnaire (Horne et al.), the Brief Illness Perception Questionnaire (Broadbent et al.). Using the study data, reliability analysis for internal consistency is satisfactory for the scales evaluating health literacy, medication knowledge, and beliefs about medications, with Chronbach's α > 0.7 for all. Reliability analysis indicated poor internal consistency for scales relating to illness perceptions. MMAS-8 and all psychometric scores are normally distributed in the study data.


DISCUSSION
This study will provide important information on the factors involved in medication non-adherence in New Zealand dialysis patients. The resulting knowledge will inform long-term initiatives to reduce medication non-adherence in dialysis patients, and help ensure that they are addressing appropriate and evidence based targets for intervention.