LLukas22/scidocs huggingface dataset:
The importance of being mobile: some social consequences of wearable augmented reality systems

What are the consequences of mobility for augmented reality? This brief paper explores some of the issues that I believe will be raised by the development and future commonplace adoption of mobile, wearable, augmented reality systems. These include: social influences on tracking accuracy, the importance of appearance and comfort, an increase in collaborative applications, integration with other devices, and implications for personal privacy.
Gemcitabine plus doxorubicin as first-line treatment in advanced or metastatic breast cancer (MBC), a phase II study.

INTRODUCTION
Doxorubicin and Gemcitabine have promising antineoplastic activity and manageable toxicity as a single agent in the treatment of patients (pts) with advanced breast cancer.


AIM OF THE STUDY
This study evaluated the efficacy and toxicity of the combination of gemcitabine plus doxorubicin as first-line treatment of advanced or MBC patients.


PATIENTS AND METHODS
Patients with advanced or MBC received gemcitabine 1250mg/m2 IV on days 1 and 8 plus doxorubicin 60mg/m2 IV on day 1 every 21 days for a maximum of 6 cycles.


RESULTS
Thirty-five patients were included, and all are evaluable for safety and efficacy. Median age was 47 years (range, 33 to 60 years). Fourteen patients (40%) were post-and 21 (60%) were premenopausal. Prior treatment included mastectomy (23pts); adjuvant nonanthracycline containing combination chemotherapy (18pts); adjuvant hormonal therapy (3pts) and 2 pts did not receive any adjuvant therapy. Twelve patients had metastatic disease at presentation. Seventeen pts were chemonaive. Hormonal receptors were positive in 6, negative in 21, and unknown in 8 pts. Site of metastasis included one site in 15 pts, two sites in 14, and three sites in 6 pts. Complete remission was observed in 6/35 (17.1%) and partial remission in 14/35 (40%) pts, for an overall response rate of 57.1%. Stable disease was observed in 8 (22.9%) and progressive disease in 7 (20%) pts. The median time to tumor progression was 7 months (range, 5-23 months; 95% CI, 6-8 months) and the median survival time was 16 months (range, 6-43 months; 95% CI, 13-19 months). The overall survival at 1 and 2 years was 74.2% and 34.2%; respectively; with 4/35 (11.4%) patients alive at 40 months. A total of 186 cycles of treatment were administered (range2-6 cycles, median 6 cycles). The doses of both doxorubicin and gemcitabine were modified after interim analysis of toxicity following the first 22 cycles administered to the first 10 patients [Mucositis grade 3-4 occurred in 6/10 (60%), grade 3-4 neutropenia in 3/10 (30%), and febrile neutropenia grade 3 in 2/10 (20%) patients] to doxorubicin 50mg/m2 on day 1 and gemcitabine to 1000 mg/m2 on days 1 and 8 in the remaining cycles. After doses reduction, the toxicity was generally tolerable.


CONCLUSION
The combination of gemcitabine plus doxorubicin after doses modification can be safely administered every 21 days with promising response as first-line therapy for MBC. The response rate, time to disease progression and overall survival rates of this regimen are comparable to other standard therapies for MBC, as well as other gemcitabine combinations.
Effects of Rikkunshito (TJ-43) on Esophageal Motor Function and Gastroesophageal Reflux

BACKGROUND/AIMS
Rikkunshito (TJ-43), an herbal medicine, has been demonstrated to relieve gastroesophageal reflux symptoms. However, the effects of TJ-43 on esophageal motor functions have not been fully determined. This double-blind crossover study was performed to investigate the effects of TJ-43 on esophageal motor functions and gastroesophageal reflux.


METHODS
The subjects were 10 normal male volunteers. Lower esophageal sphincter pressure and esophageal body peristaltic contractions with and without 1-week administration of TJ-43 were examined in a crossover fashion. Post-prandial gastroesophageal reflux was also determined using a multi-channel impedance pH dual monitor.


RESULTS
TJ-43 at a standard dose of 7.5 g/day did not significantly augment esophageal peristaltic contraction pressure measured in the proximal, middle and distal segments of the esophagus, whereas increment of resting lower esophageal sphincter pressure was observed in a supine position. In addition, TJ-43 administration did not decrease post-prandial gastroesophageal acid, non-acid reflux events or accelerate esophageal clearance time.


CONCLUSIONS
TJ-43 at a standard dose did not have a significant effect on esophageal motor activity or gastroesophageal reflux in healthy adults.
Ring Remote Phosphor Structure for Phosphor-Converted White LEDs

An efficient packaging configuration for high-power white light-emitting diodes (LEDs), consisting of an inverted cone lens encapsulant and a surrounding ring remote phosphor layer, is present. Ray-tracing simulations demonstrate that the package extraction efficiency of the ring remote phosphor structure exceeds 93%. With the implementation of the ring remote phosphor structure, the ring remote phosphor device has a maximum luminous efficacy of 145 lm/W at 20 mA and a maximum luminous flux of 132 lm at 400 mA. The enhancements are attributed to reduced absorption of the re-emitting yellow light by the LED chip, and the reduction of the trapping light inside the flat remote phosphor layer in normal remote phosphor structure.
Gaming in the clouds: QoE and the users' perspective

Cloud Gaming is a new kind of service, which combines the successful concepts of Cloud Computing and Online Gaming. It provides the entire game experience to the users remotely from a data center. The player is no longer dependent on a specific type or quality of gaming hardware, but is able to use common devices. The end device only needs a broadband internet connection and the ability to display High Definition (HD) video. While this may reduce hardware costs for users and increase the revenue for developers by leaving out the retail chain, it also raises new challenges for service quality in terms of bandwidth and latency for the underlying network. In this paper we present the results of a subjective user study we conducted into the user-perceived quality of experience (QoE) in Cloud Gaming. We design a measurement environment, that emulates this new type of service, define tests for users to assess the QoE, derive Key Influence Factors (KIF) and influences of content and perception from our results. © 2011 Elsevier Ltd. All rights reserved.
Oral tranexamic acid for the treatment of melasma.

BACKGROUND
Melasma poses a great challenge as its treatment is unsatisfactory and recurrence is high. Treatment of melasma using tranexamic acid (oral, topical or intralesional) is a novel concept.


OBJECTIVE
To compare the efficacy of oral tranexamic acid with routine topical therapies for the treatment of melasma.


METHODS
It is a prospective, interventional, randomized controlled trial conducted among 260 melasma patients. Patients were divided into two groups consisting of 130 patients each. First group (Group A) was given routine treatment measures and oral Tranexamic Acid while second group (Group B) was treated only with routine topical measures. Capsule Tranexamic Acid was prescribed at a dose of 250 mg twice a day for three months and cases were followed for three months. Response was evaluated on the basis of Melasma Assessment Severity Index (MASI). Mean scores between the two groups were then compared.


RESULTS
Statistically significant decrease in the mean Melasma Assessment Severity Index from baseline to 8 and 12 weeks was observed among group A patients (11.08±2.91 vs 8.95±2.08 at week 8 and vs. 7.84±2.44 at week 12; p<0.05 for both). While among group B patients the decrease in mean score was significant at 8 weeks and insignificant at 12 weeks follow up (11.60±3.40 vs 9.9±2.61 at 8 weeks and vs. 9.26±3 at 12 weeks; p<0.05 for former but p>0.05 for later).


CONCLUSION
Addition of oral tranexamic acid provides rapid and sustained improvement in the treatment of melasma.
Prediction Equations for Body-fat Percentage in Indian Infants and Young Children Using Skinfold Thickness and Mid-arm Circumference

The objective of the study was to develop prediction equations for fat-mass percentage in infants in India based on skinfold thickness, mid-arm circumference, and age. Skinfold thicknesses and mid-arm circumference of 46 apparently-healthy infants (27 girls and 19 boys), aged 6-24 months, from among the urban poor attending a well baby clinic of a hospital in Kolkata were measured. Their body-fat percentage was measured using the D2O dilution technique as the reference method. Equations for body-fat percentage were developed using a stepwise forward regression model using skinfold thicknesses, mid-arm circumference, and age as independent variables, and the body-fat percentage was derived by D2O dilution as the dependent variable. The new prediction equations are: body-fat percentage = -69.26+5.76xB-0.33xT2+5.40xM+0.01xA2 for girls and body-fat percentage = -8.75+3.73xB+2.57xS for boys, where B=biceps skinfold thickness, T=triceps skinfold thickness, and S=suprailiac skinfold thickness all in mm, M=mid-arm circumference in cm, and A=age in month. Using the D2O dilution technique, the means (SD) of the calculated body-fat percentage were 17.11 (7.25) for girls and 16.93 (6.62) for boys and, using the new prediction equations, these were 17.11 (6.25) for girls and 16.93 (6.02) for boys. The mean of the differences of paired values in body-fat percentage was zero. The mean (SD) of the differences of paired values for body-fat percentage derived by the D2O technique and the new equations, applied on an independent sample of 23 infants (11 girls and 12 boys) were -0.93 (6.56) for girls and 1.14 (2.43) for boys; the 95% confidence limits of the differences of paired values for body-fat percentage were -2.03 to +3.89 for girls and -0.26 to +2.54 for boys. Given that the trajectories of growth during infancy and childhood are a major risk factor for a group of diseases in adulthood, including coronary heart disease and diabetes, these predictive equations should be useful in field studies.
MeD-Lights: a usable metaphor for patient controlled access to electronic health records

Electronic health records (EHR) are poised to replace paper- based medical health records--EHRs show the promise of improving medical care by providing immediate access to a patient's records without having to worry about human-introduced delays. At the same time, mobile devices such as smartphones enable users to maintain their own medical information such as personal health records (PHR) as well as control the dissemination and sharing of their EHRs with medical personnel. Deciding what records to share with which medical personnel, however, is complicated by the many different types of records and users' varying privacy preferences. Thus, a usable model is needed to allow users to control the sharing of EHRs.
 In this paper we describe and evaluate MeD-Lights, a model that leverages the metaphor of traffic light colors (red, yellow, and green) to portray sensitivity levels of records, and how they should be shared with medical personnel. We implemented a MeD-Lights application on the Android platform and performed a user study using smartphones and show that the semantics of sharing we attach to these colors are indeed intuitive to users and users can use them effectively to manage access to their EHRs.
An Economic Analysis of Cell-Free DNA Non-Invasive Prenatal Testing in the US General Pregnancy Population

OBJECTIVE
Analyze the economic value of replacing conventional fetal aneuploidy screening approaches with non-invasive prenatal testing (NIPT) in the general pregnancy population.


METHODS
Using decision-analysis modeling, we compared conventional screening to NIPT with cell-free DNA (cfDNA) analysis in the annual US pregnancy population. Sensitivity and specificity for fetal aneuploidies, trisomy 21, trisomy 18, trisomy 13, and monosomy X, were estimated using published data and modeling of both first- and second trimester screening. Costs were assigned for each prenatal test component and for an affected birth. The overall cost to the healthcare system considered screening costs, the number of aneuploid cases detected, invasive procedures performed, procedure-related euploid losses, and affected pregnancies averted. Sensitivity analyses evaluated the effect of variation in parameters. Costs were reported in 2014 US Dollars.


RESULTS
Replacing conventional screening with NIPT would reduce healthcare costs if it can be provided for $744 or less in the general pregnancy population. The most influential variables were timing of screening entry, screening costs, and pregnancy termination rates. Of the 13,176 affected pregnancies undergoing screening, NIPT detected 96.5% (12,717/13,176) of cases, compared with 85.9% (11,314/13,176) by conventional approaches. NIPT reduced invasive procedures by 60.0%, with NIPT and conventional methods resulting in 24,596 and 61,430 invasive procedures, respectively. The number of procedure-related euploid fetal losses was reduced by 73.5% (194/264) in the general screening population.


CONCLUSION
Based on our analysis, universal application of NIPT would increase fetal aneuploidy detection rates and can be economically justified. Offering this testing to all pregnant women is associated with substantial prenatal healthcare benefits.
Corrosion fatigue behaviors of two biomedical Mg alloys - AZ91D and WE43 - In simulated body fluid.

Magnesium alloys have been recently developed as biodegradable implant materials, yet there has been no study concerning their corrosion fatigue properties under cyclic loading. In this study the die-cast AZ91D (A for aluminum 9%, Z for zinc 1% and D for a fourth phase) and extruded WE43 (W for yttrium 4%, E for rare earth mischmetal 3%) alloys were chosen to evaluate their fatigue and corrosion fatigue behaviors in simulated body fluid (SBF). The die-cast AZ91D alloy indicated a fatigue limit of 50MPa at 10⁷ cycles in air compared to 20MPa at 10⁶ cycles tested in SBF at 37°C. A fatigue limit of 110MPa at 10⁷ cycles in air was observed for extruded WE43 alloy compared to 40MPa at 10⁷ cycles tested in SBF at 37°C. The fatigue cracks initiated from the micropores when tested in air and from corrosion pits when tested in SBF, respectively. The overload zone of the extruded WE43 alloy exhibited a ductile fracture mode with deep dimples, in comparison to a brittle fracture mode for the die-cast AZ91D. The corrosion rate of the two experimental alloys increased under cyclic loading compared to that in the static immersion test.
Reconstruction for Gated Dynamic Cardiac PET Imaging Using a Tensor Product Spline Basis

A maximum likelihood reconstruction algorithm for gated dynamic cardiac PET studies was developed and evaluated. A two dimensional tensor product spline basis spanning the time and gate domain is proposed. The activity variations introduced by the biochemical kinetics and cardiac motion are modeled as conic combinations of the B-spline basis functions. The basis explicitly takes the cyclic nature of the heart motion into account. We make use of the expectation-maximization (EM) algorithm to derive a closed form iteration scheme for the reconstruction. The proposed algorithm is validated through computer simulations of the dynamic NCAT beating heart phantom and the kinetics of 13N-ammonia uptake. We used the Monte Carlo simulator GATE to simulate a typical PET scanner. We qualitatively found that a reconstruction using cubic splines resulted in smoother images while better delineating the myocardial wall. Fourth order spline modeling reduced the mean squared error (MSE) of binned reconstruction by 56% whereas conventional Gaussian filtering reduced the MSE by 38%. Spline modeling in the gate domain reduced the MSE by 72% compared to a reduction of 47% obtained with filtering. Quantitative evaluation of the reconstructed motion information suggested that the number of basis functions in the gate domain could be reduced from 16 in a framed approach to 5 for reconstructions using a higher order spline interpolation
Efficacy and safety of pamidronate in Modic type 1 changes: study protocol for a prospective randomized controlled clinical trial

BACKGROUND
Erosive degenerative disc disease, also known as Modic type 1 changes, is usually characterized by low back pain with an inflammatory pain pattern, as seen in spondyloarthropathies. Intravenous pamidronate has proven to be effective in patients with ankylosing spondylitis who are refractory to nonsteroidal antiinflammatory drugs, and in painful bone diseases in general, such as Paget's disease, fibrous dysplasia or vertebral fractures. We therefore hypothesize that pamidronate would be effective in treating low back pain associated with Modic type 1 changes.


METHODS/DESIGN
This study, called PEPTIDE (short for the French title "Etude Prospective sur l'Efficacité et la tolérance du PamidronaTe dans les dIscopathies Degeneratives Erosives"), will be a double-blind, randomized, placebo-controlled, parallel group, phase two clinical trial. A total of 48 patients will be recruited. These patients will be randomly assigned to one of the two groups, with 24 patients in each group: one group will be given pamidronate and the other a placebo. Pamidronate will be administered at a dose of 90 mg per day for two days consecutively, and every patient, irrespective of treatment group, will be given paracetamol to maintain blinding by preventing drug-induced fever. The primary outcome measure is a between-group difference of 30 points on a 100 mm Visual Analogue Scale (VAS) at three months. Secondary outcome measures are improvement in functional status and the drug's safety. Primary and secondary outcome measures will be assessed at each visit (inclusion, at six weeks, three months, and six months). If the primary goal is not attained, the patient will be offered a rigid or semi-rigid back brace, irrespective of the treatment group.


DISCUSSION
To date, only local treatments, for example intradiscal corticosteroid therapy, lumbar arthrodesis or back braces have been studied in randomized, controlled trials, with controversial results. This trial is currently ongoing and, if conclusive, should provide physicians with an acceptable alternative to those treatments. The results should be publicly available in spring 2015.


TRIAL REGISTRATION
ClinicalTrials.gov number, NCT01799616.
A Comparison of the Cell Phone Driver and the Drunk Driver

OBJECTIVE
The objective of this research was to determine the relative impairment associated with conversing on a cellular telephone while driving.


BACKGROUND
Epidemiological evidence suggests that the relative risk of being in a traffic accident while using a cell phone is similar to the hazard associated with driving with a blood alcohol level at the legal limit. The purpose of this research was to provide a direct comparison of the driving performance of a cell phone driver and a drunk driver in a controlled laboratory setting.


METHOD
We used a high-fidelity driving simulator to compare the performance of cell phone drivers with drivers who were intoxicated from ethanol (i.e., blood alcohol concentration at 0.08% weight/volume).


RESULTS
When drivers were conversing on either a handheld or hands-free cell phone, their braking reactions were delayed and they were involved in more traffic accidents than when they were not conversing on a cell phone. By contrast, when drivers were intoxicated from ethanol they exhibited a more aggressive driving style, following closer to the vehicle immediately in front of them and applying more force while braking.


CONCLUSION
When driving conditions and time on task were controlled for, the impairments associated with using a cell phone while driving can be as profound as those associated with driving while drunk.


APPLICATION
This research may help to provide guidance for regulation addressing driver distraction caused by cell phone conversations.
Routing, ship size, and sailing frequency decision-making for a maritime hub-and-spoke container network

This study formulates a two-objective model to determine the optimal liner routing, ship size, and sailing frequency for container carriers by minimizing shipping costs and inventory costs. First, shipping and inventory cost functions are formulated using an analytical method. Then, based on a trade-off between shipping costs and inventory costs, Pareto optimal solutions of the twoobjective model are determined. Not only can the optimal ship size and sailing frequency be determined for any route, but also the routing decision on whether to route containers through a hub or directly to their destination can be made in objective value space. Finally, the theoretical findings are applied to a case study, with highly reasonable results. The results show that the optimal routing, ship size, and sailing frequency with respect to each level of inventory costs and shipping costs can be determined using the proposed model. The optimal routing decision tends to be shipping the cargo through a hub as the hub charge is decreased or its efficiency improved. In addition, the proposed model not only provides a tool to analyze the trade-off between shipping costs and inventory costs, but it also provides flexibility on the decision-making for container carriers. c © 2006 Elsevier Ltd. All rights reserved.
Models of management : work, authority, and organization in a comparative perspective

Figures and Tables Preface and Acknowledgments 1: The Comparative Study of Organizational Paradigms 2: The United States: Economic Transformations, Labor Problems, and Organizational Innovations 3: Germany: Modernism, Traditionalism, and Bureaucracy 4: Spain: Eclecticism, Human Relations, and Managerial Authoritarianism in a Less-Developed Country 5: Great Britain: Industrial Retardation, Religious-Humanist Ideals, and the Rise of Social Science 6: Comparing Patterns of Adoption 7: A Historical and Comparative Perspective on Homo Hierarchicus Appendix A: Content Analysis of Journal Articles Appendix B: Comparative Statistics Appendix C: The Adoption of Scientific Management and Human Relations Techniques in the United States Appendix D: A Systematic Comparison of Conditions and Outcomes of Adoption Bibliography Index
Risk assessment and clinical impact of liquid-based cytology, oncogenic human papillomavirus (HPV) DNA and mRNA testing in primary cervical cancer screening (the FASE study).

OBJECTIVE
New commercial HPV RNA assays require further validation studies in population-based cervical cancer screening settings. To assess the performance of (FDA-approved) APTIMA® HPV Assay (AHPV), Hybrid Capture 2 (HC2), in-house PCR genotyping, and ThinPrep LBC in population-based screening, stratified by three histological gold standards.


STUDY DESIGN
A multi-center trial in 5006 women undergoing routine screening in France was designed to compare the absolute and relative risks of diagnosing CIN3+ and CIN2+ lesions by different diagnostic tests.


RESULTS
Reproducibility between the primary and second pathology reading was excellent for CIN3+ and CIN2+ endpoints (Cohen's kappa 0.948 and 0.854). Absolute risks (PPV) of different tests (AHPV, HC2, PCR genotyping, LBC) in diagnosing CIN2+ (15-20%) and CIN3+ (4-6%) were similar for the first, second, and consensus pathology readings. The relative risks of diagnosing these lesions by the four tests were also similar when the first, second or third pathology readings were employed. AHPV had the highest absolute risk of both histological endpoints, and detects 5% to 15% more CIN3+ and CIN2+ lesions, respectively, than LBC. Compared with HC2 assay, the relative risk of AHPV is 24% to 29% higher, with a significant difference in CIN2+ detection. With LBC as reference, AHPV had the best sensitivity/specificity balance measured by AUC (area under ROC curve) comparison test (significant for CIN2+), and the colposcopy referral rate (9.2%) comparable to that of LBC (8.7%).


CONCLUSIONS
These data corroborate the suitability of AHPV for the primary cervical cancer screening.