LLukas22/scidocs huggingface dataset:
A randomized trial of nortriptyline combined with transdermal nicotine for smoking cessation.

BACKGROUND
Smoking cessation rates with current therapy are suboptimal. Tricyclic antidepressants improve cessation rates. We hypothesized that addition of nortriptyline hydrochloride to transdermal nicotine would enhance cessation rates.


METHODS
We conducted a randomized, double-blind, placebo-controlled trial at a Department of Veterans Affairs medical center. Subjects were aged 18 to 65 years, smoked 10 or more cigarettes per day, and did not have current major depression. Nortriptyline hydrochloride or matched placebo was started at 25 mg 14 days before quit day, titrated to 75 mg/d as tolerated, and continued for 12 weeks after quit day. Transdermal nicotine (21 mg/d) was started on quit day and continued for 8 weeks. The behavioral intervention consisted of 12 brief, individual visits. Withdrawal symptoms were measured by means of a daily diary, and smoking cessation was defined as self-reported abstinence, expired carbon monoxide level of 9 ppm or less, and a 6-month urine cotinine level less than 50 ng/mL (284 nmol/L).


RESULTS
A total of 158 patients were randomized (79 to nortriptyline and 79 to placebo). There was no significant reduction in withdrawal symptoms. The cessation rates at 6 months were 23% (18/79) and 10% (8/79), respectively (absolute difference, 13%; 95% confidence interval, 1.3%-24.5%; P = .052). Nortriptyline caused frequent side effects, including dry mouth (38%) and sedation (20%).


CONCLUSIONS
Nortriptyline combined with transdermal nicotine resulted in an increased cessation rate with little effect on withdrawal symptoms. This combination may represent an option for smokers in whom standard therapy has failed.
The ten things you need to know about long-term outcomes following paediatric cardiac surgery

Due to improvements in care for patients with congenital heart disease (CHD) over the last 3 decades, early operative mortality for paediatric cardiac surgery is now very low: the raw 30-day mortality rate from registry data is 2–4%. This article provides ten things you need to know about long-term outcomes after paediatric cardiac surgery.
Implementation of the Six Core Strategies for Restraint Minimization in a Specialized Mental Health Organization.

Implementation of the Six Core Strategies to Reduce the Use of Seclusion and Restraint (Six Core Strategies) at a recovery-oriented, tertiary level mental health care facility and the resultant changes in mechanical restraint and seclusion incidents are described. Strategies included increased executive participation; enhanced staff knowledge, skills, and attitudes; development of restraint orders and decision support in the electronic medical record to enable informed debriefing and tracking of events; and implementation of initiatives to include service users and their families in the plan of care. Strategies were implemented in a staged manner across 3 years. The total number of mechanical restraint and seclusion incidents decreased by 19.7% from 2011/12 to 2013/14. Concurrently, the average length of a mechanical restraint or seclusion incident decreased 38.9% over the 36-month evaluation period. Implementation of the Six Core Strategies for restraint minimization effectively decreased the number and length of mechanical restraint and seclusion incidents in a specialized mental health care facility. [Journal of Psychosocial Nursing and Mental Health Services, 54(10), 32-39.].
Part-of-Speech Tagging for Twitter: Annotation, Features, and Experiments

We address the problem of part-of-speech tagging for English data from the popular microblogging service Twitter. We develop a tagset, annotate data, develop features, and report tagging results nearing 90% accuracy. The data and tools have been made available to the research community with the goal of enabling richer text analysis of Twitter and related social media data sets.
Nortriptyline and cognitive-behavioral therapy in the treatment of cigarette smoking.

BACKGROUND
A history of major depressive disorder (MDD) predicts failure to quit smoking. We determined the effect of nortriptyline hydrochloride and cognitive-behavioral therapy on smoking treatment outcome in smokers with a history of MDD. The study also addressed the effects of diagnosis and treatment condition on dysphoria after quitting smoking and the effects of dysphoria on abstinence.


METHODS
This was a 2 (nortriptyline vs placebo) x 2 (cognitive-behavioral therapy vs control) x 2 (history of MDD vs no history) randomized trial. The participants were 199 cigarette smokers. The outcome measures were biologically verified abstinence from cigarettes at weeks 12, 24, 38, and 64. Mood, withdrawal, and depression were measured at 3, 5, and 8 days after the smoking quit date.


RESULTS
Nortriptyline produced higher abstinence rates than placebo, independent of depression history. Cognitive-behavioral therapy was more effective for participants with a history of depression. Nortriptyline alleviated a negative affect occurring after smoking cessation. Increases in the level of negative affect from baseline to 3 days after the smoking quit date predicted abstinence at later assessments for MDD history-negative smokers. There was also a sex-by-depression history interaction; MDD history-positive women were less likely to be abstinent than MDD history-negative women, but depression history did not predict abstinence for men.


CONCLUSIONS
Nortriptyline is a promising adjunct for smoking cessation. Smokers with a history of depression are aided by more intensive psychosocial treatments. Mood and diagnosis interact to predict relapse. Increases in negative affect after quitting smoking are attenuated by nortriptyline.
An Integrative Contingency Model of Software Project Risk Management

Drawing both from the IS literature on software project risk management and the contingency research in Organization Theory literature, the present study develops an integrative contingency model of software project risk management. Adopting a profile deviation perspective of fit, the outcome of a software development project (Performance) is hypothesized to be influenced by the fit between the project's risk (Risk Exposure) and how project risk is managed (Risk Management Profile). The research model was tested with longitudinal data obtained from project leaders and key users of 75 software projects. The results support the contingency model proposed and suggest that in order to increase project performance a project's risk management profile needs to vary according to the project's risk exposure. Specifically, high-risk projects were found to call for high information processing capacity approaches in their management. However, the most appropriate management approach was found to depend on the perfonnance criterion used. When meeting project budgets was the performance criterion, successful high-risk projects had high levels of intemal integration, as well as high levels of formal planning. When system Journal of Manageintni tnformalioH Syslemi/Spring 2Q0l.Vo\. 17, No. 4, pp. 37-69. ©2001 M.E. Shufpc, Inr 0742-1222 / 2001 S9.50 -t0.00. 38 BARKl.RIVARD.ANDTALBOT quality was the performance criterion, successful high-risk projects had high levels of user participation.
Poly(amidoamine)-based dendrimer/siRNA complexation studied by computer simulations: effects of pH and generation on dendrimer structure and siRNA binding.

In this work we report, compare and discuss the results obtained from fully atomistic molecular dynamics simulations of generations 4, 5, and 6 of PAMAM-based dendrimers having NH(3) and triethanolamine as cores, forming complexes with a short interfering RNA (siRNA) at different pH values and at physiological ionic strength. By employing a detailed analysis we demonstrate how features such as molecular size, structural details, and protonation level of this category of dendrimers affect the dendrimer/siRNA complexation. Properties like the conformational flexibility of the dendrimer, the effective charge distribution of the assembly, and the level of intra- and intermolecular hydrogen bonding between the two molecular entities are all found to play a significant role in the mutual interactions between the nucleic acid and the hyperbranched molecules. All these features are of key importance in the multifaceted mechanism of dendrimer/gene complexation, and their understanding can provide valuable insight toward the design of more efficient nucleic acid nanocarriers.
Advanced brain computer interface for communication and control

The brain computer interface (BCI) technology allows a direct connection between brain and computer without any muscular activity required, and thus it offers a unique opportunity to enhance and/or to restore communication and actions into external word in people with severe motor disability.
 Here, we present the framework of the current research progresses regarding noninvasive EEG-based BCI applications specifically devoted to interact with the environment and other software. The P300 potentials recorded from the scalp represent a suitable BCI signal control for applications like environmental control. Here we present a set of findings that confirm the feasibility of a real domotic environmental control operated via P300-based BCI and a novelty interface approach to evoke the P300 signal.
Nup153 Unlocks the Nuclear Pore Complex for HIV-1 Nuclear Translocation in Nondividing Cells.

Human immunodeficiency virus type 1 (HIV-1) displays the unique ability to infect nondividing cells. The capsid of HIV-1 is the viral determinant for viral nuclear import. To understand the cellular factors involved in the ability of HIV-1 to infect nondividing cells, we sought to find capsid mutations that allow the virus to infect dividing but not nondividing cells. Because the interaction of capsid with the nucleoporin protein 153 (Nup153) is important for nuclear import of HIV-1, we solved new crystal structures of hexameric HIV-1 capsid in complex with a Nup153-derived peptide containing a phenylalanine-glycine repeat (FG repeat), which we used to guide structure-based mutagenesis of the capsid-binding interface. HIV-1 viruses with mutations in these capsid residues were tested for their ability to infect dividing and nondividing cells. HIV-1 viruses with capsid N57 substitutions infected dividing but not nondividing cells. Interestingly, HIV-1 viruses with N57 mutations underwent reverse transcription but not nuclear translocation. The mutant capsids also lost the ability to interact with Nup153 and CPSF6. The use of small molecules PF74 and BI-2 prevented the interaction of FG-containing nucleoporins (Nups), such as Nup153, with the HIV-1 core. Analysis of integration sites in HIV-1 viruses with N57 mutations revealed diminished integration into transcriptionally active genes in a manner resembling that of HIV-1 in CPSF6 knockout cells or that of HIV-1-N74D. The integration pattern of the N57 mutant HIV-1 can be explained by loss of capsid interaction with CPSF6, whereas capsid interaction with Nup153 is required for HIV-1 to infect nondividing cells. Additionally, the observed viral integration profiles suggested that integration site selection is a multiparameter process that depends upon nuclear factors and the state of the cellular chromatin.IMPORTANCE One of the key advantages that distinguish lentiviruses, such as HIV-1, from all other retroviruses is its ability to infect nondividing cells. Interaction of the HIV-1 capsid with Nup153 and CPSF6 is important for nuclear entry and integration; however, the contribution of each of these proteins to nuclear import and integration is not clear. Using genetics, we demonstrated that these proteins contribute to different processes: Nup153 is essential for the HIV-1 nuclear import in nondividing cells, and CPSF6 is important for HIV-1 integration. In addition, nuclear factors such as CPSF6 and the state of the chromatin are known to be important for integration site selection; nevertheless, the preferential determinant influencing integration site selection is not known. This work demonstrates that integration site selection is a multiparameter process that depends upon nuclear factors and the state of the cellular chromatin.
The Singaporean English and Chinese versions of the EQ-5D achieved measurement equivalence in cancer patients.

OBJECTIVE
To assess measurement equivalence of the Singaporean English and Chinese versions of the EuroQol Group's 5-domain questionnaire (EQ-5D) in cancer patients.


STUDY DESIGN AND SETTING
Seven hundred and seventy-one ethnic Chinese patients in Singapore were recruited, and they answered either an English or a Chinese version of the EQ-5D. Seven days later, a similar questionnaire in the same language was mailed to the patients. Regression analysis was used to assess equivalence of the mean values obtained by using the two language versions. The validity, responsiveness to change, and reliability of the two versions of the EQ-5D were assessed and compared.


RESULTS
Based on the prespecified equivalence margin of +/-10% for binary outcome, +/-0.05 for utility index, and +/-5 points in the visual analog scale, the two language versions of the EQ-5D gave equivalent mean values at item and scale levels. They also showed similar characteristics in validity, responsiveness, and reliability. For example, the test-retest reliability values for the EQ-5D utility index in the two language samples were identical in two significant digits: 0.79.


CONCLUSION
The Singaporean English and Chinese versions of the EQ-5D were validated in cancer patients and were shown to achieve measurement equivalence.
Overexpression of a trehalose-6-phosphate synthase/phosphatase fusion gene enhances tolerance and photosynthesis during drought and salt stress without growth aberrations in tomato

Trehalose is a non-reducing disaccharide of glucose that confers tolerance against abiotic stresses in many diverse organisms, including higher plants. It was previously reported that overexpression of the yeast trehalose-6-phosphate synthase gene in tomato results in improved tolerance against abiotic stresses. However, these transgenic tomato plants had stunted growth and pleiotropic changes in appearance. In this study, transgenic tomato plants were generated by the introduction of a gene encoding a bifunctional fusion of trehalose-6-phosphate synthase and trehalose-6-phosphate phosphatase genes from Escherichia coli under the control of the CaMV35S promoter. Transgenic plants accumulated higher levels of trehalose in their leaves and exhibited enhanced drought and salt tolerance and photosynthetic rates under salt stress conditions than wild-type plants. All of the transgenic plants had normal growth patterns and appearances. Therefore, the system described in this study can be used for practical application of the gene in crop improvement.
Adolescents' development of skills for agency in youth programs: learning to think strategically.

This research examines how youth in arts and leadership programs develop skills for organizing actions over time to achieve goals. Ethnically diverse youth (ages 13-21) in 11 high-quality urban and rural programs were interviewed as they carried out projects. Qualitative analyses of 712 interviews with 108 youth yielded preliminary grounded theory about youth's development of strategic thinking, defined as use of dynamic systems reasoning to anticipate real-word scenarios and plan work. Strategic thinking appeared to develop through youth's creative engagement with tactical challenges in the work and feedback from the work's outcomes. Program advisors supported this development by giving youth control and by providing nondirective assistance when needed.
Efficient Densest Subgraph Computation in Evolving Graphs

Densest subgraph computation has emerged as an important primitive in a wide range of data analysis tasks such as community and event detection. Social media such as Facebook and Twitter are highly dynamic with new friendship links and tweets being generated incessantly, calling for efficient algorithms that can handle very large and highly dynamic input data. While either scalable or dynamic algorithms for finding densest subgraphs have been proposed, a viable and satisfactory solution for addressing both the dynamic aspect of the input data and its large size is still missing. We study the densest subgraph problem in the the dynamic graph model, for which we present the first scalable algorithm with provable guarantees. In our model, edges are added adversarially while they are removed uniformly at random from the current graph. We show that at any point in time we are able to maintain a 2(1+ε)-approximation of a current densest subgraph, while requiring O(polylog(n+r)) amortized cost per update (with high probability), where r is the total number of update operations executed and n is the maximum number of nodes in the graph. In contrast, a naive algorithm that recomputes a dense subgraph every time the graph changes requires Omega(m) work per update, where m is the number of edges in the current graph. Our theoretical analysis is complemented with an extensive experimental evaluation on large real-world graphs showing that (approximate) densest subgraphs can be maintained efficiently within hundred of microseconds per update.
Proof Planning: A Fresh Start?

Proof Planning is a technique for automated (and interactive) theorem proving that searches for proof plans at the level of abstract methods. Proof methods consist of a chunk of mathematically motivated, recurring patterns of calculus level inferences with additional preand post-conditions that model their applicability conditions. Despite its partial success, proof planning has various shortcomings. In this paper we discuss some shortcomings of proof planning in the mega system. They result mainly from the strong coupling of the search for a proof plan at the method level with the underlying logic-calculus level. We present some ideas to overcome these shortcomings by separating the plan level and the calculus level completely.
Regional development in Britain

From the combination of knowledge and actions, someone can improve their skill and ability. It will lead them to live and work much better. This is why, the students, workers, or even employers should have reading habit for books. Any book will give certain knowledge to take all benefits. This is what this regional development in britain tells you. It will add more knowledge of you to life and work better. Try it and prove it.
Stroke motor recovery: active neuromuscular stimulation and repetitive practice schedules.

OBJECTIVE
To investigate progress toward motor recovery in patients with chronic hemiparesis (mean time since stroke 3.2 years), comparing different types of practice schedules.


DESIGN
To increase voluntary control of the upper extremity, active neuromuscular stimulation was administered during blocked and random practice schedules as patients performed three specific movements: wrist/finger extension, elbow joint extension, and shoulder joint abduction.


METHODS
34 stroke subjects volunteered to participate and were randomly assigned to one of three treatment groups: blocked practice (the same movement was repetitively performed on successive trials) combined with active neuromuscular stimulation; random practice (different movements on successive trials) along with active stimulation; or no active stimulation assistance control group. Subjects completed two days of 90 minute training for each of two weeks with at least 24 hours of rest between sessions. A session was three sets of 30 successful active neuromuscular stimulation trials with the three movements executed 10 times/set.


RESULTS
Mixed design analyses on three categories of behavioural measures indicated motor improvements for the blocked and random practice/stimulation groups in comparison with the control group during the post-test period, with a larger number of blocks moved, faster premotor and motor reaction times, and less variability in the sustained muscular contraction task.


CONCLUSIONS
Upper extremity rehabilitation intervention of active stimulation and blocked practice performed as well as stimulation/random practice. Moreover, these purposeful voluntary movement findings support and extend sensorimotor integration theory to both practice schedules.
Liquidity, Stock Return and Trading Volume: Measuring Causality at Multiple Horizons

The relationships between trading volume, stock return and illiquidity have long been measured separately. To offer a comprehensive study in Chinese stock market, we examine these causal relationships empirically and apply the measure of strength of causality for different horizons and directions on one of the most representative index of the market -- the SSE 50 index from it launching day 2004 till now. Since the asymptotic distribution of causality is hard to calculate, we sue a simulation-based method to estimate the confidence interval. Therefore, we notice the following causal relationships: (i) Causality is stronger at short horizons, and gradually drops down as the horizon increases; (ii) Causalities run from return and volume to illiquidity rather than the opposite direction. The former is much stronger than the latter at the beginning horizons and overwhelms at almost all following horizons; (iii) Causality trends on multi-horizons running from trade volume and return to illiquidity resemble each other, and indicate the same causal pattern mentioned in (i); (iv) Stock return and trade volume have mutual causal relationships, but the return have a stronger effect on trade volume.
Panoramic Image Mosaics

This paper presents some techniques for constructing panoramic image mosaics from sequences of images. Our mosaic representation associates a transformation matrix with each input image, rather than explicitly projecting all of the images onto a common surface (e.g., a cylinder). In particular, to construct a full view panorama, we introduce a rotational mosaic representation that associates a rotation matrix (and optionally a focal length) with each input image. A patch-based alignment algorithm is developed to quickly align two images given motion models. Techniques for estimating and refining camera focal lengths are also presented. In order to reduce accumulated registration errors, we apply global alignment (block adjustment) to the whole sequence of images, which results in an optimally registered image mosaic. To compensate for small amounts of motion parallax introduced by translations of the camera and other unmodeled distortions, we develop a local alignment (deghosting) technique which warps each image based on the results of pairwise local image registrations. By combining both global and local alignment, we significantly improve the quality of our image mosaics, thereby enabling the creation of full view panoramic mosaics with hand-held cameras. We also present an inverse texture mapping algorithm for efficiently extracting environment maps from our panoramic image mosaics. By mapping the mosaic onto an arbitrary texture-mapped polyhedron surrounding the origin, we can explore the virtual environment using standard 3D graphics viewers and hardware without requiring special-purpose players.