LLukas22/scidocs huggingface dataset:
Seasonal variability in clinical care of COPD outpatients: results from the Andalusian COPD audit

OBJECTIVES
Clinical practice in chronic obstructive pulmonary disease (COPD) can be influenced by weather variability throughout the year. To explore the hypothesis of seasonal variability in clinical practice, the present study analyzes the results of the 2013-2014 Andalusian COPD audit with regard to changes in clinical practice according to the different seasons.


METHODS
The Andalusian COPD audit was a pilot clinical project conducted from October 2013 to September 2014 in outpatient respiratory clinics of hospitals in Andalusia, Spain (8 provinces with more than 8 million inhabitants) with retrospective data gathering. For the present analysis, astronomical seasons in the Northern Hemisphere were used as reference. Bivariate associations between the different COPD guidelines and the clinical practice changes over the seasons were explored by using binomial multivariate logistic regression analysis with age, sex, Charlson comorbidity index, type of hospital, and COPD severity by forced expiratory volume in 1 second as covariates, and were expressed as odds ratio (OR) with 95% confidence intervals (CIs).


RESULTS
The Andalusian COPD audit included 621 clinical records from 9 hospitals. After adjusting for covariates, only inhaler device satisfaction evaluation was found to significantly differ according to the seasons with an increase in winter (OR, 3.460; 95% CI, 1.469-8.151), spring (OR, 4.215; 95% CI, 1.814-9.793), and summer (OR, 3.371; 95% CI, 1.391-8.169) compared to that in autumn. The rest of the observed differences were not significant after adjusting for covariates. However, compliance with evaluating inhaler satisfaction was low.


CONCLUSION
The various aspects of clinical practice for COPD care were found to be quite homogeneous throughout the year for the variables evaluated. Inhaler satisfaction evaluation, however, presented some significant variation during the year. Inhaler device satisfaction should be evaluated during all clinical visits throughout the year for improved COPD management.
Factors associated with prospective long-term treatment adherence among individuals with bipolar disorder.

OBJECTIVE
Clinical characteristics, adverse effects of medication, and treatment attitudes have been associated with adherence in bipolar populations in cross-sectional studies. The aim of this secondary analysis from a larger study was to identify the association between baseline variables and average treatment adherence over a subsequent three-year period.


METHODS
Veterans with bipolar disorder were evaluated on self-reported adherence status at baseline and every six months over a three-year period. The sample was dichotomized into two clinically relevant categories: those who were primarily adherent and those who were primarily nonadherent. Demographic and clinical variables were examined for the two groups of patients in relation to their average adherence over the three-year period.


RESULTS
The study recruited a sample of 306 persons with severe bipolar disorder. The sample was predominantly male (278 men, or 91%), with a mean+/-SD age of 46.6+/-10.1 years. A total of 240 individuals (78%) were largely adherent to treatment, and 37 individuals (12%) were largely nonadherent to treatment. Nonadherent individuals were less likely to be on intensive somatotherapy regimens (p=.001); experienced more barriers to care, including lack of telephone access (p<.05) and life obligations and commitments (p<.05); and had more prior suicide attempts (p=.003).


CONCLUSIONS
Nonadherent individuals with bipolar disorder received less intensive pharmacologic treatments, had more suicide attempts, and experienced more barriers to care than adherent individuals. Nonadherence may have system as well as patient components. Consideration of nonadherence as a function of both patient factors and system factors will enhance our ability to understand nonadherence and intervene more effectively.
Planetary Rover Developments Supporting Mars Exploration, Sample Return and Future Human-Robotic Colonization

We overview our recent research on planetary mobility. Products of this effort include the Field Integrated Design & Operations rover (FIDO), Sample Return Rover (SRR), reconfigurable rover units that function as an All Terrain Explorer (ATE), and a multi-Robot Work Crew of closely cooperating rovers (RWC). FIDO rover is an advanced technology prototype; its design and field testing support NASA’s development of long range, in situ Mars surface science missions. Complementing this, SRR implements autonomous visual recognition, navigation, rendezvous, and manipulation functions enabling small object pick-up, handling, and precision terminal docking to a Mars ascent vehicle for future Mars Sample Return. ATE implements on-board reconfiguration of rover geometry and control for adaptive response to adverse and changing terrain, e.g., traversal of steep, sandy slopes. RWC implements coordinated control of two rovers under closed loop kinematics and force constraints, e.g., transport of large payloads, as would occur in robotic colonies at future Mars outposts. RWC is based in a new extensible architecture for decentralized control of, and collective state estimation by multiple heterogeneous robotic platforms—CAMPOUT; we overview the key architectural features. We have conducted experiments with all these new rover system concepts over variable natural terrain. For each of the above developments, we summarize our approach, some of our key experimental results to date, and our future directions of planned development.
Discriminatively boosted image clustering with fully convolutional auto-encoders

Traditional image clustering methods take a two-step approach, feature learning and clustering, sequentially. However, recent research results demonstrated that combining the separated phases in a unified framework and training them jointly can achieve a better performance. In this paper, we first introduce fully convolutional auto-encoders for image feature learning and then propose a unified clustering framework to learn image representations and cluster centers jointly based on a fully convolutional auto-encoder and soft k-means scores. At initial stages of the learning procedure, the representations extracted from the auto-encoder may not be very discriminative for latter clustering. We address this issue by adopting a boosted discriminative distribution, where high score assignments are highlighted and low score ones are de-emphasized. With the gradually boosted discrimination, clustering assignment scores are discriminated and cluster purities are enlarged. Experiments on several vision benchmark datasets show that our methods can achieve a state-of-the-art performance.
Effects of low-intensity laser therapy on the orthodontic movement velocity of human teeth: a preliminary study.

BACKGROUND AND OBJECTIVES
Low-intensity laser therapy (LILT) has been studied in many fields of dentistry, but to our knowledge, this is the first time that its effects on orthodontic movement velocity in humans are investigated.


STUDY DESIGN/PATIENTS AND METHODS
Eleven patients were recruited for this 2-month study. One half of the upper arcade was considered control group (CG) and received mechanical activation of the canine teeth every 30 days. The opposite half received the same mechanical activation and was also irradiated with a diode laser emitting light at 780 nm, during 10 seconds at 20 mW, 5 J/cm2, on 4 days of each month. Data of the biometrical progress of both groups were statistically compared.


RESULTS
All patients showed significant higher acceleration of the retraction of canines on the side treated with LILT when compared to the control.


CONCLUSIONS
Our findings suggest that LILT does accelerate human teeth movement and could therefore considerably shorten the whole treatment duration.
How does climate change influence Arctic mercury?

Recent studies have shown that climate change is already having significant impacts on many aspects of transport pathways, speciation and cycling of mercury within Arctic ecosystems. For example, the extensive loss of sea-ice in the Arctic Ocean and the concurrent shift from greater proportions of perennial to annual types have been shown to promote changes in primary productivity, shift foodweb structures, alter mercury methylation and demethylation rates, and influence mercury distribution and transport across the ocean-sea-ice-atmosphere interface (bottom-up processes). In addition, changes in animal social behavior associated with changing sea-ice regimes can affect dietary exposure to mercury (top-down processes). In this review, we address these and other possible ramifications of climate variability on mercury cycling, processes and exposure by applying recent literature to the following nine questions; 1) What impact has climate change had on Arctic physical characteristics and processes? 2) How do rising temperatures affect atmospheric mercury chemistry? 3) Will a decrease in sea-ice coverage have an impact on the amount of atmospheric mercury deposited to or emitted from the Arctic Ocean, and if so, how? 4) Does climate affect air-surface mercury flux, and riverine mercury fluxes, in Arctic freshwater and terrestrial systems, and if so, how? 5) How does climate change affect mercury methylation/demethylation in different compartments in the Arctic Ocean and freshwater systems? 6) How will climate change alter the structure and dynamics of freshwater food webs, and thereby affect the bioaccumulation of mercury? 7) How will climate change alter the structure and dynamics of marine food webs, and thereby affect the bioaccumulation of marine mercury? 8) What are the likely mercury emissions from melting glaciers and thawing permafrost under climate change scenarios? and 9) What can be learned from current mass balance inventories of mercury in the Arctic? The review finishes with several conclusions and recommendations.
Dysfunction of ventral striatal reward prediction in schizophrenia

BACKGROUND
Negative symptoms may be associated with dysfunction of the brain reward system in schizophrenia. We used functional magnetic resonance imaging (fMRI) to assess the BOLD response in the ventral striatum of unmedicated schizophrenics during presentation of reward-indicating and loss-indicating stimuli.


METHODS
A total of 10 schizophrenic men (7 never medicated, 3 unmedicated for at least 2 years) and 10 age-matched healthy male volunteers participated in an incentive monetary delay task, in which visual cues predicted that a rapid response to a subsequent target stimulus would result either in monetary gain or loss or would have no consequence.


RESULTS
Compared to healthy controls, unmedicated schizophrenics showed reduced ventral striatal activation during the presentation of reward-indicating cues. Decreased activation of the left ventral striatum was inversely correlated with the severity of negative (and trendwise positive) symptoms.


DISCUSSION
Reduced activation in one of the central areas of the brain reward system, the ventral striatum, was correlated with the severity of negative symptoms in medication-free schizophrenics. In unmedicated schizophrenic patients, a high striatal dopamine turnover may increase the "noise" in the reward system, thus interfering with the neuronal processing of reward-predicting cues by phasic dopamine release. This, in turn, may contribute to negative symptoms as such as anhedonia, apathy, and loss of drive and motivation.
Judiciaries in Comparative Perspective: Table of statutes

Part I: 1. Judicial independence and accountability: core values in liberal democracies Shimon Shetreet Part II: 2. Appointment, discipline and removal of judges in Australia H. P. Lee 3. Appointment, discipline and removal of judges in Canada Martin Friedland 4. Appointment, discipline and removal of judges in New Zealand Philip Joseph 5. Appointment, discipline and removal of judges in South Africa Hugh Corder 6. Appointment, discipline and removal of judges - fundamental reforms in the United Kingdom Kate Malleson 7. Judicial selection, removal and discipline in the United States Mark Tushnet Part III: 8. Judges' freedom of speech: Australia John Williams 9. Judges and free speech in Canada Kent Roach 10. Judges and free speech in New Zealand The Hon. Grant Hammond 11. The judiciary and freedom of speech in South Africa Iain Currie 12. Judges and free speech in the United Kingdom Keith Ewing 13. The criticism and speech of judges in the United States Charles Gardner Geyh Part IV: 14. Judges, bias and recusal in Australia Colin Campbell 15. Judges, bias and recusal in Canada Lorne Soissin 16. Judicial recusal in New Zealand Gerard McCoy 17. Judges, bias and recusal in South Africa The Hon. Kate O'Regan and The Hon. Edwin Cameron 18. Judges, bias and recusal in the United Kingdom Christopher Forsyth 19. Bias, the appearance of bias, and judicial disqualification in the United States W. W. Hodes Part V: 20. Judges and non-judicial functions in Australia Patrick Emerton and H. P. Lee 21. The impact of extra-judicial service on the Canadian judiciary: the need for reform Patrick Monahan and Byron Shaw 22. Judges and the non-judicial function in New Zealand Sir Geoffrey Palmer 23. Judges and non-judicial functions in South Africa Cora Hoexter 24. Judges and non-judicial functions in the United Kingdom Abimbola Olowofoyeku 25. Judges and non-judicial functions in the United States Jeffrey M. Shaman Part VI: 26. The judiciary - a comparative conspectus H. P. Lee.
Particle-size distributions and seasonal diversity of allergenic and pathogenic fungi in outdoor air

Fungi are ubiquitous in outdoor air, and their concentration, aerodynamic diameters and taxonomic composition have potentially important implications for human health. Although exposure to fungal allergens is considered a strong risk factor for asthma prevalence and severity, limitations in tracking fungal diversity in air have thus far prevented a clear understanding of their human pathogenic properties. This study used a cascade impactor for sampling, and quantitative real-time PCR plus 454 pyrosequencing for analysis to investigate seasonal, size-resolved fungal communities in outdoor air in an urban setting in the northeastern United States. From the 20 libraries produced with an average of ∼800 internal transcribed spacer (ITS) sequences (total 15 326 reads), 12 864 and 11 280 sequences were determined to the genus and species levels, respectively, and 558 different genera and 1172 different species were identified, including allergens and infectious pathogens. These analyses revealed strong relationships between fungal aerodynamic diameters and features of taxonomic compositions. The relative abundance of airborne allergenic fungi ranged from 2.8% to 10.7% of total airborne fungal taxa, peaked in the fall, and increased with increasing aerodynamic diameter. Fungi that can cause invasive fungal infections peaked in the spring, comprised 0.1–1.6% of fungal taxa and typically increased in relative abundance with decreasing aerodynamic diameter. Atmospheric fungal ecology is a strong function of aerodynamic diameter, whereby through physical processes, the size influences the diversity of airborne fungi that deposit in human airways and the efficiencies with which specific groups of fungi partition from outdoor air to indoor environments.
Solar Atmospheric Neutrinos: A New Neutrino Floor for Dark Matter Searches

Kenny C. Y. Ng, 2, 3, ∗ John F. Beacom, 3, 4, † Annika H. G. Peter, 3, 4, ‡ and Carsten Rott § Department of Particle Physics and Astrophysics, Weizmann Institute of Science, Rehovot, Israel Center for Cosmology and AstroParticle Physics (CCAPP), Ohio State University, Columbus, OH 43210 Department of Physics, Ohio State University, Columbus, OH 43210 Department of Astronomy, Ohio State University, Columbus, OH 43210 Department of Physics, Sungkyunkwan University, Suwon 440-746, Korea (Dated: 30 March 2017)
Ulnar-sided wrist pain. II. Clinical imaging and treatment

Pain at the ulnar aspect of the wrist is a diagnostic challenge for hand surgeons and radiologists due to the small and complex anatomical structures involved. In this article, imaging modalities including radiography, arthrography, ultrasound (US), computed tomography (CT), CT arthrography, magnetic resonance (MR) imaging, and MR arthrography are compared with regard to differential diagnosis. Clinical imaging findings are reviewed for a more comprehensive understanding of this disorder. Treatments for the common diseases that cause the ulnar-sided wrist pain including extensor carpi ulnaris (ECU) tendonitis, flexor carpi ulnaris (FCU) tendonitis, pisotriquetral arthritis, triangular fibrocartilage complex (TFCC) lesions, ulnar impaction, lunotriquetral (LT) instability, and distal radioulnar joint (DRUJ) instability are reviewed.
Hemispatial neglect and rehabilitation in acute stroke.

OBJECTIVES
To compare 2 methods for determining neglect in patients within 2 days of stroke, and to investigate whether early neglect was related to rehabilitation practice, and whether this relationship was affected by an early, intensive mobilization intervention.


DESIGN
Data were collected from patients participating in a phase II randomized controlled trial of early rehabilitation after stroke.


SETTING
Acute hospital stroke unit.


PARTICIPANTS
Stroke patients (N=71).


INTERVENTION
The 2 arms of the trial were very early mobilization (VEM) and standard care (SC).


MAIN OUTCOME MEASURES
Neglect was assessed using the Star Cancellation Test and the National Institutes of Health Stroke Scale (NIHSS) inattention item within 48 hours of stroke onset, and therapy details were recorded during the hospital stay.


RESULTS
Assessing neglect so acutely after stroke was difficult: 29 of the 71 patients were unable to complete the Star Cancellation Test, and agreement between this test and the NIHSS measure was only .42. Presence of neglect did not preclude early mobilization. SC group patients with neglect had longer hospital stays (median, 11d) than those without neglect (median, 4d); there was no difference in length of stay between patients with and without neglect in the VEM group (median, 6d in both).


CONCLUSION
Early mobilization of patients with neglect was feasible and may contribute to a shorter acute hospital stay.
Molecular targets of non-steroidal anti-inflammatory drugs in neurodegenerative diseases

During the last decade, interest has grown in the beneficial effects of non-steroidal anti-inflammatory drugs (NSAIDs) in neurodegeneration, particularly in pathologies such as Alzheimer’s (AD) and Parkinson’s (PD) disease. Evidence from epidemiological studies has indicated a decreased risk for AD and PD in patients with a history of chronic NSAID use. However, clinical trials with NSAIDs in AD patients have yielded conflicting results, suggesting that these drugs may be beneficial only when used as preventive therapy or in early stages of the disease. NSAIDs may also have salutary effects in other neurodegenerative diseases with an inflammatory component, such as multiple sclerosis and amyotrophic lateral sclerosis. In this review we analyze the molecular (cyclooxygenases, secretases, NF-κB, PPAR, or Rho-GTPasas) and cellular (neurons, microglia, astrocytes or endothelial cells) targets of NSAIDs that may mediate the therapeutic function of these drugs in neurodegeneration.
Peptide and protein transdermal drug delivery.

Peptides and proteins are gaining increasing importance as therapeutic agents. Oral delivery of these molecules is not feasible due to gastrointestinal degradation. Parenteral delivery leads to poor patient compliance especially because the short half-life of peptides necessitates repeated administration. Passive transdermal delivery is not feasible but active transdermal delivery of peptides and proteins is a promising alternative route of administration which can bypass gastrointestinal degradation and offer patient compliance. This review discusses active transdermal technologies for delivery of peptides and proteins.
A controlled study of community-based exercise training in patients with moderate COPD

BACKGROUND
The effectiveness of clinic-based pulmonary rehabilitation in advanced COPD is well established, but few data exist for less severe patients treated in alternative settings. The purpose of this study was to investigate whether a novel, community-based exercise program (CBE) was feasible and effective for patients with moderate COPD.


METHODS
Nineteen patients with moderate COPD (mean FEV1 62%) and self-reported exercise impairment were randomized to 12-weeks of progressive endurance and strength training at a local health club under the guidance of a certified personal trainer, or to continuation of unsupervised habitual physical activity. Outcomes assessed at baseline and 12 weeks included session compliance, intensity adherence, treadmill endurance time, muscle strength, dyspnea, and health status.


RESULTS
Compliance was 94% and adherence was 83%. Comparisons between CBE and control groups yielded the following mean (SEM) differences in favor of CBE: endurance time 134 (74) seconds versus -59 (49) seconds (P=0.041) and TDI 5.1 (0.8) versus -0.2 (0.5) (P<0.001). The CBE group increased muscle strength (weight lifted) by 11.8 kilograms per subject per week of training (P<0.001). SGRQ was not significantly changed.


CONCLUSIONS
We demonstrated the feasibility and effectiveness of a novel community-based exercise program involving health clubs and personal trainers for patients with moderate COPD.


TRIAL REGISTRATION
ClinicalTrials.gov Identifier NCT01985529.
Essays on obligation

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Linguistics and Philosophy, 2007.
A Gedanken Experiment For Gravitomagnetism

A gedanken experiment implies the existence of gravitomagnetism and raises a question about what we know about the weak-field limit of the gravitomagnetic field of General Relativity.
Evaluation of Haar Cascade Classifiers Designed for Face Detection

In the past years a lot of effort has been made in the field of face detection. The human face contains important features that can be used by vision-based automated systems in order to identify and recognize individuals. Face location, the primary step of the vision-based automated systems, finds the face area in the input image. An accurate location of the face is still a challenging task. Viola-Jones framework has been widely used by researchers in order to detect the location of faces and objects in a given image. Face detection classifiers are shared by public communities, such as OpenCV. An evaluation of these classifiers will help researchers to choose the best classifier for their particular need. This work focuses of the evaluation of face detection classifiers minding facial landmarks. Keywords—Face datasets, face detection, facial landmarking, haar wavelets, Viola-Jones detectors.