LLukas22/scidocs huggingface dataset:
The effect of a patient centred care bundle intervention on pressure ulcer incidence (INTACT): A cluster randomised trial.

BACKGROUND
Hospital-acquired pressure ulcers are a serious patient safety concern, associated with poor patient outcomes and high healthcare costs. They are also viewed as an indicator of nursing care quality.


OBJECTIVE
To evaluate the effectiveness of a pressure ulcer prevention care bundle in preventing hospital-acquired pressure ulcers among at risk patients.


DESIGN
Pragmatic cluster randomised trial.


SETTING
Eight tertiary referral hospitals with >200 beds each in three Australian states.


PARTICIPANTS
1600 patients (200/hospital) were recruited. Patients were eligible if they were: ≥18 years old; at risk of pressure ulcer because of limited mobility; expected to stay in hospital ≥48h and able to read English.


METHODS
Hospitals (clusters) were stratified in two groups by recent pressure ulcer rates and randomised within strata to either a pressure ulcer prevention care bundle or standard care. The care bundle was theoretically and empirically based on patient participation and clinical practice guidelines. It was multi-component, with three messages for patients' participation in pressure ulcer prevention care: keep moving; look after your skin; and eat a healthy diet. Training aids for patients included a DVD, brochure and poster. Nurses in intervention hospitals were trained in partnering with patients in their pressure ulcer prevention care. The statistician, recruiters, and outcome assessors were blinded to group allocation and interventionists blinded to the study hypotheses, tested at both the cluster and patient level. The primary outcome, incidence of hospital-acquired pressure ulcers, which applied to both the cluster and individual participant level, was measured by daily skin inspection.


RESULTS
Four clusters were randomised to each group and 799 patients per group analysed. The intraclass correlation coefficient was 0.035. After adjusting for clustering and pre-specified covariates (age, pressure ulcer present at baseline, body mass index, reason for admission, residence and number of comorbidities on admission), the hazard ratio for new pressure ulcers developed (pressure ulcer prevention care bundle relative to standard care) was 0.58 (95% CI: 0.25, 1.33; p=0.198). No adverse events or harms were reported.


CONCLUSIONS
Although the pressure ulcer prevention care bundle was associated with a large reduction in the hazard of ulceration, there was a high degree of uncertainty around this estimate and the difference was not statistically significant. Possible explanations for this non-significant finding include that the pressure ulcer prevention care bundle was effective but the sample size too small to detect this.
Seroprevalence and Risk Factors for Leptospira Seropositivity in Beef Cattle, Sheep and Deer Farmers in New Zealand.

Leptospirosis is a global zoonosis that in New Zealand affects primarily people occupationally exposed to livestock. The objective of this study was to estimate the seroprevalence of five Leptospira serovars in farmers working on cattle, sheep and deer farms that had the serological status of animals previously assessed and to identify risk factors for farmer seropositivity. A total of 178 farmers from 127 properties participated in the study. Blood samples were tested using the microscopic agglutination test (MAT) for the presence of antibodies to Leptospira. Samples with a MAT titre ≥48 were considered seropositive. Using Bayesian statistical analysis, the median seroprevalence of Leptospira, all serovars combined, was estimated to be 6.6% (95% probability interval (PI) 3.6-10.9%). Risk factors associated with seropositivity were assisting deer or cattle calving, farming deer, having ≥25% of flat terrain and high abundance of wild deer on farm, while high possum abundance on farm was negatively associated with seropositivity. No association was observed between farmer serostatus and previously recorded livestock serology. Leptospira seropositivity was associated with influenza-like illness of farmers (RR = 1.7; 95% PI 1.0-2.5). Assuming a causal relationship, this suggested an annual risk of 1.3% (95% PI 0.0-3.0%) of influenza-like illnesses due to Leptospira infection in the population of farmers. The association between seropositivity and disease can be used to estimate the public health burden of leptospirosis in New Zealand. Identifying and understanding risk factors for Leptospira seropositivity can inform preventive measures, hence contributing to the reduction of leptospirosis incidence in farmers.
Isolated anterior talofibular ligament Broström repair for chronic lateral ankle instability: 9-year follow-up.

BACKGROUND
Lateral ankle sprains may result in pain and disability in the short term, decreased sport activity and early retirement from sports in the mid term, and secondary injuries and development of early osteoarthritis to the ankle in the long term.


HYPOTHESIS
This combined approach to chronic lateral instability and intra-articular lesions of the ankle is safe and in the long term maintains mechanical stability, functional ability, and a good level of sport activity.


STUDY DESIGN
Case series; Level of evidence, 4.


METHODS
We present the long-term outcomes of 42 athletes who underwent ankle arthroscopy and anterior talofibular Broström repair for management of chronic lateral ankle instability. We assessed in all patients preoperative and postoperative anterior drawer test and side-to-side differences, American Orthopaedic Foot and Ankle Society (AOFAS) score, and Kaikkonen grading scales. Patients were asked about return to sport and level of activity. Patients were also assessed for development of degenerative changes to the ankle, and preoperative versus postoperative findings were compared.


RESULTS
Thirty-eight patients were reviewed at an average of 8.7 years (range, 5-13 years) after surgery; 4 patients were lost to follow-up. At the last follow-up, patients were significantly improved for ankle laxity, AOFAS scores, and Kaikkonen scales. The mean AOFAS score improved from 51 (range, 32-71) to 90 (range, 67-100), and the mean Kaikkonen score improved from 45 (range, 30-70) to 90 (range, 65-100). According to outcome criteria set preoperatively, there were 8 failures by the AOFAS score and 9 by the Kaikkonen score. Twenty-two (58%) patients practiced sport at the preinjury level, 6 (16%) had changed to lower levels but were still active in less demanding sports (cycling and tennis), and 10 (26%) had abandoned active sport participation although they still were physically active. Six of these patients did not feel safe with their ankle because of the occurrence of new episodes of ankle instability. Of the 27 patients who had no evidence of degenerative changes preoperatively, 8 patients (30%) had radiographic signs of degenerative changes (5 grade I and 3 grade II) of the ankle; 4 of the 11 patients (11%) with preexisting grade I changes remained unchanged, and 7 patients (18%) had progressed to grade II. No correlation was found between osteoarthritis and status of sport activity (P = .72).


CONCLUSION
Combined Broström repair and ankle arthroscopy are safe and allow most patients to return to preinjury daily and sport activities.
Meta-knowledge in systems design: panacea ... or undelivered promise?

In this study we present a review of the emerging eld of meta-knowledge components as practised over the past decade among a variety of practitioners. We use the arti cially-de ned term `meta-knowledge' to encompass all those di erent but overlapping notions used by the Arti cial Intelligence and Software Engineering communities to represent reusable modelling frameworks: ontologies, problem-solving methods, experience factories and experience bases, patterns, to name a few. We then elaborate on how meta-knowledge is deployed in the context of system's design to improve its reliability by consistency checking, enhance its reuse potential, and manage its knowledge sharing. We speculate on its usefulness and explore technologies for supporting deployment of meta-knowledge. We argue that, despite the di erent approaches being followed in systems design by divergent communities, meta-knowledge is present in all cases, in a tacit or explicit form, and its utilisation depends on pragmatic aspects which we try to identify and critically review on criteria of e ectiveness. keywords: Ontologies, Problem-Solving Methods, Experienceware, Patterns, Design Types, Cost-E ective Analysis.
White rice, brown rice, and risk of type 2 diabetes in US men and women.

BACKGROUND
Because of differences in processing and nutrients, brown rice and white rice may have different effects on risk of type 2 diabetes mellitus. We examined white and brown rice consumption in relation to type 2 diabetes risk prospectively in the Health Professionals Follow-up Study and the Nurses' Health Study I and II.


METHODS
We prospectively ascertained and updated diet, lifestyle practices, and disease status among 39,765 men and 157,463 women in these cohorts.


RESULTS
After multivariate adjustment for age and other lifestyle and dietary risk factors, higher intake of white rice (> or =5 servings per week vs <1 per month) was associated with a higher risk of type 2 diabetes: pooled relative risk (95% confidence interval [CI]), 1.17 (1.02-1.36). In contrast, high brown rice intake (> or =2 servings per week vs <1 per month) was associated with a lower risk of type 2 diabetes: pooled relative risk, 0.89 (95% CI, 0.81-0.97). We estimated that replacing 50 g/d (cooked,equivalent to one-third serving per day) intake of white rice with the same amount of brown rice was associated with a 16% (95% CI, 9%-21%) lower risk of type 2 diabetes,whereas the same replacement with whole grains as a group was associated with a 36% (30%-42%) lower diabetes risk [corrected].


CONCLUSIONS
Substitution of whole grains, including brown rice, for white rice may lower risk of type 2 diabetes. These data support the recommendation that most carbohydrate intake should come from whole grains rather than refined grains to help prevent type 2 diabetes.
Consistency of Online Random Forests

As a testament to their success, the theory of random forests has long been outpaced by their application in practice. In this paper, we take a step towards narrowing this gap by providing a consistency result for online random forests.
Testing the Home Literacy Model: Parent Involvement in Kindergarten Is Differentially Related to Grade 4 Reading Comprehension, Fluency, Spelling, and Reading for Pleasure.

This study examines the longitudinal relations among early literacy experiences at home and children’s kindergarten literacy skills, Grade 1 word reading and spelling skills, and Grade 4 reading comprehension, fluency, spelling, and reading for pleasure. Ninety French-speaking children were tested at the end of kindergarten and Grade 1, and 65 were followed until the end of Grade 4. Parents reported in kindergarten that storybook reading occurred frequently and that they sometimes taught their child to read words. The results of hierarchical regression analyses that controlled for parent education as well as concurrent and longitudinal relations among literacy behaviors reveal that parent teaching about literacy in kindergarten directly predicted kindergarten alphabet knowledge and Grade 4 reading fluency, whereas storybook exposure directly predicted kindergarten vocabulary and the frequency with which children reported reading for pleasure in Grade 4. Moreover, storybook exposure predicted Grade 4 reading comprehension indirectly. These findings extend the Home Literacy Model proposed by Sénéchal and LeFevre (2002).
SCOPE AND LIMITATION OF ELECTRONIC VOTING SYSTEM

Electronic Voting are now being performed using World Wide Web in many countries of the world due to this advancement a voter need not to visit the polling place. But has to just logging on the computer with an internet connection. Also, thi s voting requires an access code for the e-voting through the advance report of a voter. To reduce these disadvantages, we suggest a process in which a voter, who has the wireless certificate issued in advance, uses its own mobile phone for an e-voting without the unique r gistration for a vote. In this paper, a polling scheme by mean s of mobile technology is resented as most fundamental applicat ion of GSM based Personal Response System, which allows a vote r t cast his vote in simple and convenient way without the limit of time and location by integrating an electronic voting method with the GSM infrastructure. Key Terms: Voting; Mobile Terminal; Confidentiali ty; Anonymity Full Text: http://www.ijcsmc.com/docs/papers/May2013/V2I5201354.pdf
Insect exocrine glands.

Fig. 1. Noirot and Quennedey's original classification of insect exocrine glands, based on a rhinotermitid sternal gland. The asterisk indicates a subcuticular space. Abbreviations: C, cuticle; D, duct cells; G1, secretory cells class 1; G2, secretory cells class 2; G3, secretory cells class 3; S, campaniform sensilla (modified after Noirot and Quennedey, 1974). ‘Describe the differences between endocrine and exocrine glands’, it sounds a typical exam question from a general biology course during our time at high school. Because of their secretory products being released to the outside world, exocrine glands definitely add flavour to our lives. Everybody is familiar with their secretions, from the salty and perhaps unpleasantly smelling secretions from mammalian sweat glands to the sweet exudates of the honey glands used by some caterpillars to attract ants, from the most painful venoms of bullet ants and scorpions to the precious wax that honeybees use to make their nest combs. Besides these functions, exocrine glands are especially known for the elaboration of a broad spectrum of pheromonal substances, and can also be involved in the production of antibiotics, lubricants, and digestive enzymes. Modern research in insect exocrinology started with the classical works of Charles Janet, who introduced a histological approach to the insect world (Billen and Wilson, 2007). The French school of insect anatomy remained strong since then, and the commonly used classification of insect exocrine glands generally follows the pioneer paper of Charles Noirot and Andr e Quennedey (1974). These authors were leading termite researchers using their extraordinary knowledge on termite glands to understand related phenomena, such as foraging and reproductive behaviour. They distinguish between class 1 with secretory cells adjoining directly to the cuticle, and class 3 with bicellular units made up of a large secretory cell and its accompanying duct cell that carries the secretion to the exterior (Fig. 1). The original classification included also class 2 secretory cells, but these are very rare and are only found in sternal and tergal glands of a cockroach and many termites (and also in the novel nasus gland described in this issue!). This classification became universally used, with the rather strange consequence that the vast majority of insect glands is illogically made up of class 1 and class 3 cells. In a follow-up paper, the uncommon class 2 cells were re-considered as oenocyte homologues (Noirot and Quennedey, 1991). Irrespectively of these objections, their 1974 pioneer paper is a cornerstone of modern works dealing with insect exocrine glands, as is also obvious in the majority of the papers in this special issue. This paper already received 545 citations at Web of Science and 588 at Google Scholar (both on 24 Aug 2015), so one can easily say that all researchers working on insect glands consider this work truly fundamental. Exocrine glands are organs of cardinal importance in all insects. The more common ones include mandibular and labial
Alemtuzumab versus interferon beta-1a in early relapsing-remitting multiple sclerosis: post-hoc and subset analyses of clinical efficacy outcomes

BACKGROUND
Alemtuzumab is a humanised monoclonal antibody that depletes lymphocytes, causing long-term immunomodulation. In a 3-year, rater-blinded phase 2 study (the CAMMS223 study) in patients with relapsing-remitting multiple sclerosis (RRMS), alemtuzumab reduced relapse rate and the risk of sustained accumulation of disability compared with subcutaneous interferon beta-1a, and the mean expanded disability status scale (EDSS) score of the alemtuzumab cohort improved compared with baseline. Adverse events included infusion-associated reactions, predominantly mild to moderate infections, thyroid disorders, and immune thrombocytopenia. In this study, we further analysed the CAMMS223 data with the aim of determining whether demographic and baseline disease-related characteristics affect the beneficial effects of alemtuzumab. Additionally, we aimed to describe a new outcome measure in multiple sclerosis research: sustained reduction in disability.


METHODS
334 treatment-naive patients with active, early RRMS were randomly assigned in a 1:1:1 ratio to receive interferon beta-1a (44 μg subcutaneously three times per week), or 24 mg per day or 12 mg per day alemtuzumab intravenously for 2 or 3 annual cycles. We analysed freedom from clinical disease activity (CDA; defined as no relapses and no sustained accumulation of disability) and occurrence of sustained reduction in disability (SRD; a ≥1 point decrease on the EDSS sustained for 6 consecutive months for patients with a baseline EDSS ≥2), and analysed efficacy outcomes for subgroups based on age, sex, geographic region, MRI-T1 brain volume, MRI-T2 lesion volume, disease duration, number of previous relapses within 2 years, and EDSS.


FINDINGS
322 patients were analysed. 161 of 215 patients treated with alemtuzumab were free of CDA at 36 months (Kaplan-Meier estimate 71·8%, 95% CI 63·1-78·8%) compared with 52 of 107 patients treated with interferon beta-1a (42·6%, 32·4-52·4%; hazard ratio [HR]=0·31, 0·20-0·46; p<0·0001). For the 199 patients with a baseline EDSS score greater than or equal to 2, SRD was more likely (HR=2·61, 1·54-4·43; p=0·0004) among patients treated with alemtuzumab (66 of 133 patients, Kaplan-Meier estimate 51·6%, 95% CI 43·2-60·7%) than patients treated with interferon beta-1a (15 of 66 patients, 27·2%, 17·2-41·4%). All disability and relapse outcomes showed evidence of beneficial effects of alemtuzumab compared with interferon beta-1a across all analysed patient subsets, and no subgroup of patients consistently responded better than others to alemtuzumab.


INTERPRETATION
Alemtuzumab reduced disease activity compared with interferon beta-1a in most of the analysed subgroups. Significantly greater numbers of patients experienced sustained improvement in disability after treatment with alemtuzumab than interferon beta-1a. The efficacy offered by alemtuzumab is a substantial advance in the treatment of multiple sclerosis.


FUNDING
Genzyme and Bayer Schering Pharma.
Software fault prediction: A literature review and current trends

0957-4174/$ see front matter 2010 Elsevier Ltd. A doi:10.1016/j.eswa.2010.10.024 E-mail addresses: cagatay.catal@bte.mam.gov.tr, ca Software engineering discipline contains several prediction approaches such as test effort prediction, correction cost prediction, fault prediction, reusability prediction, security prediction, effort prediction, and quality prediction. However, most of these prediction approaches are still in preliminary phase and more research should be conducted to reach robust models. Software fault prediction is the most popular research area in these prediction approaches and recently several research centers started new projects on this area. In this study, we investigated 90 software fault prediction papers published between year 1990 and year 2009 and then we categorized these papers according to the publication year. This paper surveys the software engineering literature on software fault prediction and both machine learning based and statistical based approaches are included in this survey. Papers explained in this article reflect the outline of what was published so far, but naturally this is not a complete review of all the papers published so far. This paper will help researchers to investigate the previous studies from metrics, methods, datasets, performance evaluation metrics, and experimental results perspectives in an easy and effective manner. Furthermore, current trends are introduced and discussed. 2010 Elsevier Ltd. All rights reserved.
Identification and prospective validation of clinically relevant chronic obstructive pulmonary disease (COPD) subtypes.

BACKGROUND
Chronic obstructive pulmonary disease (COPD) is increasingly considered a heterogeneous condition. It was hypothesised that COPD, as currently defined, includes different clinically relevant subtypes.


METHODS
To identify and validate COPD subtypes, 342 subjects hospitalised for the first time because of a COPD exacerbation were recruited. Three months after discharge, when clinically stable, symptoms and quality of life, lung function, exercise capacity, nutritional status, biomarkers of systemic and bronchial inflammation, sputum microbiology, CT of the thorax and echocardiography were assessed. COPD groups were identified by partitioning cluster analysis and validated prospectively against cause-specific hospitalisations and all-cause mortality during a 4 year follow-up.


RESULTS
Three COPD groups were identified: group 1 (n=126, 67 years) was characterised by severe airflow limitation (postbronchodilator forced expiratory volume in 1 s (FEV(1)) 38% predicted) and worse performance in most of the respiratory domains of the disease; group 2 (n=125, 69 years) showed milder airflow limitation (FEV(1) 63% predicted); and group 3 (n=91, 67 years) combined a similarly milder airflow limitation (FEV(1) 58% predicted) with a high proportion of obesity, cardiovascular disorders, diabetes and systemic inflammation. During follow-up, group 1 had more frequent hospitalisations due to COPD (HR 3.28, p<0.001) and higher all-cause mortality (HR 2.36, p=0.018) than the other two groups, whereas group 3 had more admissions due to cardiovascular disease (HR 2.87, p=0.014).


CONCLUSIONS
In patients with COPD recruited at their first hospitalisation, three different COPD subtypes were identified and prospectively validated: 'severe respiratory COPD', 'moderate respiratory COPD', and 'systemic COPD'.
Computed tomography (CT) of the chest at less than 1 mSv: an ongoing prospective clinical trial of chest CT at submillisievert radiation doses with iterative model image reconstruction and iDose4 technique.

PURPOSE
To assess lesion detection and diagnostic confidence of computed tomography (CT) of the chest performed at less than 1 mSv with 2 iterative reconstruction (IR) techniques.


MATERIALS AND METHODS
Ten patients gave written informed consent for the acquisitions of images at submillisievert dose (0.9 mSv), in addition to clinical standard-dose (SD) chest CT (2.9 mSv). Submillisievert images were reconstructed with iDose and iterative model reconstruction (IMR). Two radiologists assessed lesion detection, margins, diagnostic confidence, and visibility of small structures. Objective noise and noise spectral density were measured.


RESULTS
Lesion detection was identical for standard-dose filtered back projection (FBP), submSv iDose, and submSv IMR. Lesion margins were better seen for 30% of detected lung lesions with submSv IMR compared to standard-dose FBP and submSv iDose (P < 0.05). Visibility of abdominal structures, and diagnostic confidence with submSv iDose and submSv IMR were similar to standard-dose FBP. There was 21% to 64% noise reduction with submSv IMR and 1% to 15% higher noise with iDose compared to standard-dose FBP (P < 0.0001).


CONCLUSIONS
Submillisievert IMR improves delineation of lesion margins compared to standard-dose FBP and submSv iDose.