LLukas22/scidocs huggingface dataset:
Low-volume, high-intensity interval training in patients with CAD.

PURPOSE
Isocaloric interval exercise training programs have been shown to elicit improvements in numerous physiological indices in patients with CAD. Low-volume high-intensity interval exercise training (HIT) is effective in healthy populations; however, its effectiveness in cardiac rehabilitation has not been established. This study compared the effects of 12-wk of HIT and higher-volume moderate-intensity endurance exercise (END) on brachial artery flow-mediated dilation (FMD) and cardiorespiratory fitness (VO2 peak) in patients with CAD.


METHODS
Twenty-two patients with documented CAD were randomized into HIT (n = 11) or END (n = 11) based on pretraining FMD. Both groups attended two supervised sessions per week for 12 wk. END performed 30-50 min of continuous cycling at 58% peak power output (PPO), whereas HIT performed ten 1-min intervals at 89% PPO separated by 1-min intervals at 10% PPO per session.


RESULTS
Relative FMD was increased posttraining (END, 4.4% ± 2.6% vs 5.9% ± 3.6%; HIT, 4.6% ± 3.6% vs 6.1% ± 3.4%, P ≤ 0.001 pre- vs posttraining) with no differences between groups. A training effect was also observed for relative VO2 peak (END, 18.7 ± 5.7 vs 22.3 ± 6.1 mL · kg(-1) · min(-1); HIT, 19.8 ± 3.7 vs 24.5 ± 4.5 mL · kg(-1) · min(-1), P < 0.001 for pre- vs posttraining), with no group differences.


CONCLUSIONS
Low-volume HIT provides an alternative to the current, more time-intensive prescription for cardiac rehabilitation. HIT elicited similar improvements in fitness and FMD as END, despite differences in exercise duration and intensity.
Modeling and Rendering Escher-Like Impossible Scenes

Inspired by the drawings of “impossible” objects by artists such as M.C. Escher, we describe a mathematical theory which captures some of the underlying principles of their work. Using this theory, we show how impossible three-dimensional scenes may be modeled and rendered synthetically.
Deep-learning: investigating deep neural networks hyper-parameters and comparison of performance to shallow methods for modeling bioactivity data

BACKGROUND
In recent years, research in artificial neural networks has resurged, now under the deep-learning umbrella, and grown extremely popular. Recently reported success of DL techniques in crowd-sourced QSAR and predictive toxicology competitions has showcased these methods as powerful tools in drug-discovery and toxicology research. The aim of this work was dual, first large number of hyper-parameter configurations were explored to investigate how they affect the performance of DNNs and could act as starting points when tuning DNNs and second their performance was compared to popular methods widely employed in the field of cheminformatics namely Naïve Bayes, k-nearest neighbor, random forest and support vector machines. Moreover, robustness of machine learning methods to different levels of artificially introduced noise was assessed. The open-source Caffe deep-learning framework and modern NVidia GPU units were utilized to carry out this study, allowing large number of DNN configurations to be explored.


RESULTS
We show that feed-forward deep neural networks are capable of achieving strong classification performance and outperform shallow methods across diverse activity classes when optimized. Hyper-parameters that were found to play critical role are the activation function, dropout regularization, number hidden layers and number of neurons. When compared to the rest methods, tuned DNNs were found to statistically outperform, with p value <0.01 based on Wilcoxon statistical test. DNN achieved on average MCC units of 0.149 higher than NB, 0.092 than kNN, 0.052 than SVM with linear kernel, 0.021 than RF and finally 0.009 higher than SVM with radial basis function kernel. When exploring robustness to noise, non-linear methods were found to perform well when dealing with low levels of noise, lower than or equal to 20%, however when dealing with higher levels of noise, higher than 30%, the Naïve Bayes method was found to perform well and even outperform at the highest level of noise 50% more sophisticated methods across several datasets.
A case study in pervasive retail

In this paper we discuss the rationale for the development of MyGrocer, a second-generation pervasive retail system, as well as its implications for the fast moving consumer goods (FMCG) sector. We will only touch upon the technology infrastructure and the required technical developments since these have been discussed extensively elsewhere. The focus here is on the one hand, on the analysis of the business forces that dictate the development of pervasive retail and on the other, the implications and the opportunities for innovative business models offered by the dis-intermediation effect of pervasive retail on the supply chain of FMCG. The MyGrocer system has undergone two phases of field-testing and is expected to be fully operational by the end of this year. The development of the MyGrocer architecture is a collaborative effort between industry and academia within Europe.
Simulation of single phase SPWM ( Unipolar ) inverter

In this paper, a simulation of SPWM (Unipolar) strategy is presented for single phase full bridge inverter. The simulation of the single-phase unipolar voltage switching inverter device model is simulated in Matlab/Simulink. The modulation ratio change from 0.4 to 0.9 by varying amplitude of modulating signal. The outputs voltage and current %THD waveforms for variable AC voltages and modulation index are observed on scope, and also see the THD.SPWM techniques are characterized by constant amplitude pulses with different duty cycle for each period. The width of this pulses are modulated in order to obtain inverter output voltage control and to reduce its harmonic content. Sinusoidal pulse width modulation or SPWM is the most common method in motor control and inverter application. Conventionally, to generate the signal, triangle wave as a carrier signal is compared with the sinusoidal wave, whose frequency is the desired frequency. In next the hardware design for unipolar voltage switching for inverter for fixed modulation index and is tested for different resistive loads. Keywords-Sinusoidal pulse width modulation (SPWM), Bipolar, Total Harmonic distortion (THD). Pulse Width Modulation (PWM), UPS (uninterruptible power supplies).
Chondrogenic differentiation of rat MSCs on porous scaffolds of silk fibroin/chitosan blends.

Adult bone marrow derived mesenchymal stem cells are undifferentiated, multipotential cells and have the potential to differentiate into multiple lineages like bone, cartilage or fat. In this study, polyelectrolyte complex silk fibroin/chitosan blended porous scaffolds were fabricated and examined for its ability to support in vitro chondrogenesis of mesenchymal stem cells. Silk fibroin matrices provide suitable substrate for cell attachment and proliferation while chitosan are promising biomaterial for cartilage repair due to it's structurally resemblance with glycosaminoglycans. We compared the formation of cartilaginous tissue in the silk fibroin/chitosan blended scaffolds with rat mesenchymal stem cells and cultured in vitro for 3 weeks. Additionally, pure silk fibroin scaffolds of non-mulberry silkworm, Antheraea mylitta and mulberry silkworm, Bombyx mori were also utilized for comparative studies. The constructs were analyzed for cell attachment, proliferation, differentiation, histological and immunohistochemical evaluations. Silk fibroin/chitosan blended scaffolds supported the cell attachment and proliferation as indicated by SEM observation, Confocal microscopy and metabolic activities. Alcian Blue and Safranin O histochemistry and expression of collagen II indicated the maintenance of chondrogenic phenotype in the constructs after 3 weeks of culture. Glycosaminoglycans and collagen accumulated in all the scaffolds and was highest in silk fibroin/chitosan blended scaffolds and pure silk fibroin scaffolds of A. mylitta. Chondrogenic differentiation of MSCs in the silk fibroin/chitosan and pure silk fibroin scaffolds was evident by real-time PCR analysis for cartilage-specific ECM gene markers. The results represent silk fibroin/chitosan blended 3D scaffolds as suitable scaffold for mesenchymal stem cells-based cartilage repair.
vSked: evaluation of a system to support classroom activities for children with autism

Visual schedules--the use of symbols to represent a series of activities or steps--have been successfully used by caregivers to help children with autism to understand, structure, and predict activities in their daily lives. Building from in-depth fieldwork and participatory design sessions, we developed vSked, an interactive and collaborative visual scheduling system designed for elementary school classrooms. We evaluated vSked in situ in one autism-specific classroom over three weeks. In this paper, we present the design principles, technical solution, and results from this successful deployment. Use of vSked resulted in reductions in staff effort required to use visual supports. vSked also resulted in improvements in the perceived quality and quantity of communication and social interactions in the classroom.
A NOVEL WIDE-BAND MICROSTRIP YAGI-UDA ARRAY ANTENNA FOR WLAN APPLICATIONS

This paper presents a design of Wide-Band Microstrip Yagi-Uda antenna with high gain and high front to back (F/B) ratio. Numerical and measured results of our design show more than 18 dB front to back ratio at 5.5 GHz and no backward radiation at 5.2GHz. An impedance bandwidth of 22.05% was achieved around 5.5GHz. The antenna gain (10–12.4 dBi) can be varied to be suitable for various applications. Measured return loss and radiation pattern of this antenna is presented to validate the results of simulations by two methods. The first method based on finite element method (FEM) and the second one based on finite integral technique (FIT) were used to analyze antenna structure, and subsequently the Genetic Algorithm (GA) was applied by using HFSS simulator to obtain the optimized parameters. In order to find the best design method for this antenna, the effect of distance between the parasitic elements of proposed antenna was studied. Finally two microstrip Yagi-Uda array antennas were combined to increase the gain of antenna. To demonstrate the major benefits, a comparison of our initial and final designs of Yagi-Uda antenna is provided.
From ACE to ZINC Examples on the use of SDTM Controlled Terminology for lab tests

The mapping of lab tests to the Laboratory Test Code controlled terminology in CDISC-SDTM § can be a challenge. One has to find candidates in the extensive controlled terminology list. Then there can be multiple lab tests that map to a single SDTM controlled term. This means additional variables must be used in order to produce a unique test definition (e.g. LBCAT, LBSPEC, LBMETHOD and/or LBELTM). Finally, it can occur that a controlled term is not available and a code needs to be defined in agreement with the rules for Lab tests. This paper describes my experience with the implementation of SDTM controlled terminology for lab tests during an SDTM conversion activity. In six clinical studies 124 lab tests were mapped to 101 SDTM controlled terms. The lab tests included routine lab parameters, coagulation parameters, hormones, glucose tolerance test and pregnancy test. INTRODUCTION This paper aims to give detailed examples of SDTM LB datasets that were created for six studies included in an FDA submission. Background information on the conversion project that formed the context of this work can be found in an earlier PhUSE contribution [1]. With the exception of part of the hormone data all laboratory data of these studies had been extracted from the Oracle Clinical TM NORMLAB2 system, which delivered complete and standardized lab data, i.e. standardized parameter (lab test) names, values, units and ranges. Subsequently, these NORMLAB2 extracts had been enriched with derived variables and records, following internal data standards and conventions, to form standardized analysis-ready datasets. These were the basis for conversion to SDTM LB datasets. The combined source datasets of the six studies held 124 distinct lab tests, which were mapped to 101 distinct lab controlled terms. Controlled terminology for lab tests is part of the SDTM terminology, which is published on the NCI EVS website [2]. New lab test terms have been released for public review through a series of packages [3], starting in 2007. Since version 3.1.2. of the SDTM Implementation Guide [4], the use of SDTM controlled terminology for lab tests is assumed for LBTESTCD and LBTEST (codelists C65047 and C67154). Table 1 provides an overview of the number of lab tests per study in the source data vs. the SDTM datasets (i.e. the number of LBTEST/LBTESTCD codes) and shows how these codes were distributed across different lab test categories. A set of 22 ‘routine safety parameters’ occurred in all four phase III studies (001-004), with 16 tests occurring in all six studies. § Clinical Data Interchange Standards Consortium Study Data Tabulation Model δ National Cancer Institute Enterprise Vocabulary Services
Decoding LoRa: Realizing a Modern LPWAN with SDR

LoRa is an emerging Low Power Wide Area Network (LPWAN), a type of wireless communication technology suitable for connecting low power embedded devices over long ranges. This paper details the modulation and encoding elements that comprise the LoRa PHY, the structure of which is the result of the author’s recent blind analysis of the protocol. It also introduces grlora, an open source software defined implementation of the PHY that will empower wireless developers and security researchers to investigate this nascent protocol.
Application of PLC for Elevator Control System

In this research paper an attempt has been made to integrate the programmable logic controller (PLC) with elevator for developing its control system. Thus, this paper describes the application of programmable logic controller for elevator control system. The PLC used for this project is GE FANUC with six inputs and four outputs. The programming language used is ladder diagram.
The at-risk registers in severe asthma (ARRISA) study: a cluster-randomised controlled trial examining effectiveness and costs in primary care.

BACKGROUND
Patients at risk of severe exacerbations contribute disproportionally to asthma mortality, morbidity and costs. We evaluated the effectiveness and costs of using 'asthma risk registers' for these patients in primary care.


METHODS
In a cluster-randomised trial, 29 primary care practices identified 911 at-risk asthma patients using British asthma guideline criteria (severe asthma plus adverse psychosocial characteristics). Intervention practices added electronic alerts to identified patients' records to flag their at-risk status and received practice-based training about using the alerts to improve patient access and opportunistic management. Control practices continued routine care. Numbers of patients experiencing the primary outcome of a moderate-severe exacerbation (resulting in death, hospitalisation, accident and emergency attendance, out-of-hours contact, or a course/boost in oral prednisolone for asthma), other healthcare and medication usage, and costs over 1 year were derived from practice-based records.


RESULTS
There was no significant effect on exacerbations (control: 46.5%; intervention: 53.6%, OR, 95% CI 1.30, 0.93 to 1.80). However, this composite outcome masked relative reductions in intervention patients experiencing hospitalisations (OR 0.50, 95% CI 0.26 to 0.94), accident and emergency (OR 0.74, 95% CI 0.42 to 1.31) and out-of-hours contacts (OR 0.79, 95% CI 0.45 to 1.37); and a relative increase in prednisolone prescription for exacerbations (OR 1.31, 95% CI 0.92 to 1.85). Furthermore, prescription of nebulised short-acting β-agonists reduced and long-acting β-agonists increased for intervention relative to control patients. The adjusted mean per patient healthcare cost was £138.21 lower (p=0.837) among intervention practices.


CONCLUSION
Using asthma risk registers in primary care did not reduce treated exacerbations, but reduced hospitalisations and increased prescriptions of recommended preventative therapies without increasing costs.
[Temporal evolution of treatment of patients with atrial fibrillation in a urban health care area].

BACKGROUND AND OBJECTIVE
To evaluate the adequacy of atrial fibrillation (AF) management 6 years after the establishment of a coordinated AF Unit.


PATIENTS AND METHODS
Patients with AF attended during 14 consecutive days in the Emergency Room, Internal Medicine, Neurology and Arrhythmia departments of a tertiary hospital, and 3 primary health care centers of the same urban health care area were included. Treatment for AF and its adequacy to current clinical guidelines, tests performed and knowledge about the arrhythmia were evaluated. Results were compared with a population of 239 patients treated 6 years earlier.


RESULTS
One hundred and sixty-eight patients were included. Knowledge of the arrhythmia improved. The adequacy of treatment (rate control, rhythm control and antithrombotic prophylaxis) remained at the same level as in the previous period in all areas. The adequacy of thromboprophylaxis was negatively associated with advanced age (P < .001) and positively associated with knowledge of arrhythmia (P = .026).


CONCLUSION
Treatment of AF in a coordinated health area remains appropriate 6 years after the establishment of a coordinated AF unit. Elderly patients are still poorly anticoagulated. Health education may improve this deficit.
What Does a Chief Digital Officer Do? Managerial Tasks and Roles of a New C-Level Position in the Context of Digital Transformation

Integrating "digital" into the DNA of their business models is an essential part of business success for companies across industries today. The digital transformation has become a critical management issue and requires new ways of managerial thinking. In this context, we address one of the fastest-growing phenomena at top management level: the establishment of Chief Digital Officers (CDOs). We adopt a phenomenon-based research methodology and describe the managerial tasks and roles of CDOs by conducting case studies across different industries. As a result, we present a first conceptualization of the CDO position, suggesting that CDOs primarily focus on the strategic and communicational aspects of the digital transformation and closely collaborate with their CIOs if both positions exist in a company.
Comparison of a vitamin E-rich diet and supplemental vitamin E on measures of vitamin E status and lipoprotein profile

Objective: To determine whether dietary modification rather than use of supplements can raise indices of vitamin E status to potentially cardioprotective levels.Design: Eight week randomised controlled trial with parallel treatments to compare increased use of vitamin E-rich foods, supplementation with 200 IU of vitamin E, and a placebo.Setting: Dunedin, New Zealand.Subjects: Ninety subjects were recruited, of whom 82 non-smoking, free-living individuals aged 22–72 y with plasma cholesterol <7.5 mmol/l completed the trial.Main outcome measures: Dietary intakes, plasma alpha tocopherol, plasma alpha tocopherol/cholesterol ratio and lipoprotein cholesterol.Results: Consumption of an additional 12 mg of vitamin E (alpha tocopherol equivalents) from dietary sources was primarily achieved through the replacement of saturated fat-rich foods with unsaturated fats rich in vitamin E, nuts and vegetables. This resulted in a 3.4 μmol/l increase in plasma alpha tocopherol at week 6 (95% CI 1.6–5.3), and 0.9 μmol/mmol in plasma alpha tocopherol/cholesterol at weeks 4 and 6 (95% CI 0.3–1.4 and 0.4–1.4, respectively) when compared with the placebo group. In the supplement group, plasma alpha tocopherol and plasma alpha tocopherol/cholesterol were significantly increased within 2 weeks and remained so throughout the 8 week intervention.Conclusion: Increasing dietary vitamin E intake can increase plasma alpha tocopherol levels, although factors other than dietary intake are also important determinants. The extent of dietary modification required to achieve potentially cardioprotective levels of plasma alpha tocopherol is difficult in practice.Sponsorship: The study was supported through the Otago Medical Research Foundation Laurenson Award.European Journal of Clinical Nutrition (2001) 55, 555–561
A Review of the Effects of Seismic Surveys on Marine Mammals

rine mammals and noise by Richardson and colleagues (Richardson et al., 1995) summarized most of the relevant work up to that date. Since then a number of reviews have focused on air gun noise and marine mammals, including Evans and Nice (1996), Richardson and Würsig (1997), and Gausland (2000). Harwood and Wilson (2001) consider the issue in a risk assessment framework, while an expert panel have provided recommendations on levels of exposure and mitigation procedures likely to minimize risk to marine mammals (HESS, 1997). A series of reports by the National Academy of Sciences have reviewed and summarized information relating underwater noise and marine mammals and made recommendations for future research (e.g., M I N T R O D U C T I O N arine seismic surveys produce some of the most intense manmade noises in the oceans and these surveys often operate over extensive areas for extended periods of time. The juxtaposition of intense sound sources and acoustically sensitive marine mammals must give rise to concerns about possible adverse impacts. Powerful sounds can potentially have a number of effects on marine mammals. In this review, we divide possible effects into four categories: physical (including physiological) effects, perceptual effects, behavioral effects, and indirect effects. Possible physical and physiological effects include damage to body tissues, gross damage to ears, permanent threshold shift (PTS. i.e. permanent reduc-
Is mitral E/E' ratio a reliable predictor of left ventricular diastolic pressures in patients without heart failure?

UNLABELLED
Aim Conflicting evidence exists as to whether the mitral E/E' ratio can be a reliable predictor of the left ventricular end-diastolic pressure (LVEDP). Our aim was to assess the value of the mitral E/E' ratio for the estimation of left ventricular diastolic pressures (LVDP) in patients without heart failure (HF).


METHODS AND RESULTS
Echo-Doppler examination and left heart catheterization were carried out in 100 consecutive patients to assess the correlation between echo-Doppler parameters and the LVDP. The E/A ratio showed the best correlation with the pre-a LVDP and the LVEDP, whereas septal and mean E/E' ratios were significantly correlated with pre-a LVDP but not with the LVEDP. No difference in the echo-Doppler parameters was found between patients with normal and elevated LVEDP. Mitral E/E' ratio was significantly higher in patients with an ejection fraction (EF) <50% compared with those with the EF ≥ 50% and in patients with a dilated left ventricular (LV) compared with those with a normal LV. No significant difference in mean LVEDP was found among the three groups with E/E' ratios of <8, 8-15, and >15. The best cut-off values identified by receiver operating characteristic curve analysis for septal, lateral, and mean E/E' had sensitivities of 53, 68, and 54% and specificities of 66, 51, and 69% for identifying a >15 mmHg LVEDP.


CONCLUSION
In patients without HF mitral E/E' ratio is influenced by EF and LV volumes and is better correlated with the pre-a LVDP than with the LVEDP. The suboptimal sensitivity and specificity of E/E' for predicting increased LVDP suggest that the mitral E/E' ratio is of limited clinical value in patients without HF.