LLukas22/scidocs huggingface dataset:
A prospective, double-blind, randomized controlled trial of the angiotensin-converting enzyme inhibitor Ramipril In Aortic Stenosis (RIAS trial)

AIMS
Angiotensin-converting enzyme (ACE) inhibitors improve left ventricular (LV) remodelling and outcome in heart failure and hypertensive heart disease. They may be similarly beneficial in patients with aortic stenosis (AS), but historical safety concerns have limited their use, and no prospective clinical trials exist.


METHODS AND RESULTS
We conducted a prospective, randomized, double-blind, placebo-controlled trial in 100 patients with moderate or severe asymptomatic AS to examine the physiological effects of ramipril, particularly LV mass (LVM) regression. Subjects were randomized to ramipril 10 mg daily (n = 50) or placebo (n = 50) for 1 year, and underwent cardiac magnetic resonance, echocardiography, and exercise testing at 0, 6, and 12 months, with follow-up data available in 77 patients. There was a modest but progressive reduction in LVM (the primary end point) in the ramipril group vs. the placebo group (mean change -3.9 vs. +4.5 g, respectively, P = 0.0057). There were also trends towards improvements in myocardial physiology: the ramipril group showed preserved tissue Doppler systolic velocity compared with placebo (+0.0 vs. -0.5 cm/s, P = 0.04), and a slower rate of progression of the AS (valve area 0.0 cm(2) in the ramipril group vs. -0.2 cm(2) in the placebo arm, P = 0.067). There were no significant differences in major adverse cardiac events.


CONCLUSION
ACE inhibition leads to a modest, but progressive reduction in LVM in asymptomatic patients with moderate-severe AS compared with placebo, with trends towards improvements in myocardial physiology and slower progression of valvular stenosis. A larger clinical outcome trial to confirm these findings and explore their clinical relevance is required.
Early tectonic zones in the baltic shield

Abstract A pattern of mainly NW-striking tectonic zones is described in the western part of the Northeastern European Platform.
Wear of human enamel opposing monolithic zirconia, glass ceramic, and composite resin: an in vitro study.

STATEMENT OF PROBLEM
Demand is increasing for ceramic and composite resin posterior restorations. However, ceramics are recognized for their high abrasiveness to opposing dental structure.


PURPOSE
The purpose of this study was to investigate the wear of enamel as opposed to dental ceramics and composite resin.


MATERIAL AND METHODS
Twenty-four test specimens (antagonists), 6 each of monolithic zirconia, glass ceramic, composite resin, and enamel, were prepared into cylindrical rods. Enamel specimens were prepared from 24 extracted human permanent molar teeth. Enamel specimens were abraded against each type of antagonist with a pin-on-disk wear tester under a constant load of 25 N at 20 rpm for 4800 cycles. The maximum depth of wear (Dmax), mean depth of wear (Da), and mean surface roughness (Ra) of the enamel specimens were measured with a profilometer. All data were statistically analyzed by 1-way ANOVA, followed by the Tukey test (α=.05). A paired t test was used to compare the Ra of enamel at baseline and after testing. The wear of both the enamel and antagonists was evaluated qualitatively with scanning electron microscopic images.


RESULTS
No significant differences were found in enamel wear depth (Dmax, Da) between monolithic zirconia (2.17 ±0.80, 1.83 ±0.75 μm) and composite resin (1.70 ±0.92, 1.37 ±0.81 μm) or between glass ceramic (8.54 ±2.31, 7.32 ±2.06 μm) and enamel (10.72 ±6.31, 8.81 ±5.16 μm). Significant differences were found when the enamel wear depth caused by monolithic zirconia and composite resin was compared with that of glass ceramic and enamel (P<.001). The Ra of enamel specimens increased significantly after wear tests with monolithic zirconia, glass ceramic, and enamel (P<.05); however, no difference was found among these materials.


CONCLUSIONS
Within the limitations of this in vitro study, monolithic zirconia and composite resin resulted in less wear depth to human enamel compared with glass ceramic and enamel. All test materials except composite resin similarly increased the enamel surface roughness after wear testing.
Melanocortin 4 receptor mutations in a large cohort of severely obese adults: prevalence, functional classification, genotype-phenotype relationship, and lack of association with binge eating.

CONTEXT
Heterozygous mutations in the melanocortin-4 receptor (MC4R) gene are the most common monogenic form of severe obesity in children. There are conflicting reports regarding the prevalence, nature, and pathogenic effects of MC4R mutations in adults with severe late-onset obesity.


OBJECTIVE
Our objective was to determine the prevalence of MC4R mutations in a cohort of severely obese adults and to determine the clinical phenotype and the phenotype-genotype relationship within adult MC4R mutation carriers.


DESIGN AND SETTING
We conducted an observational study at a referral center.


PATIENTS OR OTHER PARTICIPANTS
Participants included 769 adult patients with body mass index of at least 35 kg/m(2) and 444 nonobese control individuals.


INTERVENTIONS
There were no interventions.


MAIN OUTCOME MEASURES
We assessed the prevalence of pathogenic MC4R mutations, functional characteristics of the detected mutations, phenotype, and phenotype-genotype relationship within mutation carriers.


RESULTS
The global prevalence of obesity-specific MC4R mutations was 2.6%, and the 95% confidence interval (CI(95)) was 1.5-3.7. The prevalence of MC4R mutations was similar in patients developing obesity in childhood (2.83%; CI(95), 0.9-4.8) and in patients with a later onset of the disease (2.35%; CI(95), 0.9-3.8). Adult obese MC4R mutation carriers did not present with binge eating or with any specific clinical phenotype. The severity of the functional alterations of the mutated MC4Rs and in particular the intracellular retention of the receptor correlates both with the severity and the onset of the obesity in the mutation carriers.


CONCLUSIONS
Obese adult carriers of functionally relevant MC4R mutations do not specifically present with binge-eating disorder or a history of early-onset obesity. The onset and severity of the obesity in the carriers is related to the functional severity of the MC4R mutations.
Brown–Sequard syndrome produced by cervical disc herniation with complete neurologic recovery: report of three cases and review of the literature

Study design:Case report.Objective:To report three cases of Brown–Sequard syndrome (BSS) associated with cervical disc herniation.Method:We describe clinical and radiographic review of three patients who presented with BSS caused by cervical disc herniation. Three patients presented with ipsilateral motor weakness and diminished sensation to pain and temperature on the contralateral side. Magnetic resonance images of the cervical spine in all cases, showed a large paramedian disc herniation at C5–C6, with ipsilateral severe spinal cord compression. Microsurgical removal of the herniated disc via anterior foraminotomy was performed and complete decompression of the spinal cord was achieved.Results:Postoperatively, the neurological symptoms recovered rapidly with a complete remission of their symptoms.Conclusion:Although BSS is rarely associated with degenerative cervical spine disease, cervical disc herniation should be kept in mind and prompt evaluation is indicated. Anterior foraminotomy suffices for spinal cord decompression with improvement of the neurological function.
Governance and the Capacity to Manage Resilience in Regional Social-Ecological Systems

The sustainability of regional development can be usefully explored through several different lenses. In situations in which uncertainties and change are key features of the ecological landscape and social organization, critical factors for sustainability are resilience, the capacity to cope and adapt, and the conservation of sources of innovation and renewal. However, interventions in social-ecological systems with the aim of altering resilience immediately confront issues of governance. Who decides what should be made resilient to what? For whom is resilience to be managed, and for what purpose? In this paper we draw on the insights from a diverse set of case studies from around the world in which members of the Resilience Alliance have observed or engaged with sustainability problems at regional scales. Our central question is: How do certain attributes of governance function in society to enhance the capacity to manage resilience? Three specific propositions were explored: (1) participation builds trust, and deliberation leads to the shared understanding needed to mobilize and self-organize; (2) polycentric and multilayered institutions improve the fit between knowledge, action, and social-ecological contexts in ways that allow societies to respond more adaptively at appropriate levels; and (3) accountable authorities that also pursue just distributions of benefits and involuntary risks enhance the adaptive capacity of vulnerable groups and society as a whole. Some support was found for parts of all three propositions. In exploring the sustainability of regional social-ecological systems, we are usually faced with a set of ecosystem goods and services that interact with a collection of users with different technologies, interests, and levels of power. In this situation in our roles as analysts, facilitators, change agents, or stakeholders, we not only need to ask: The resilience of what, to what? We must also ask: For whom?
Investigating the contribution of short wavelengths in the alerting effect of bright light

INTRODUCTION
Short-wavelengths can have an acute impact on alertness, which is allegedly due to their action on intrinsically photosensitive retinal ganglion cells. Classical photoreceptors cannot, however, be excluded at this point in time as contributors to the alerting effect of light. The objective of this study was to compare the alerting effect at night of a white LED light source while wearing blue-blockers or not, in order to establish the contribution of short-wavelengths.


MATERIALS AND METHODS
20 participants stayed awake under dim light (< 5 lx) from 23:00 h to 04:00 h on two consecutive nights. On the second night, participants were randomly assigned to one light condition for 30 min starting at 3:00 h. Group A (5M/5F) was exposed to 500 μW/cm(2) of unfiltered LED light, while group B (4M/6F) was required to wear blue-blocking glasses, while exposed to 1500 μW/cm(2) from the same light device in order to achieve 500 μW/cm(2) at eye level (as measured behind the glasses). Subjective alertness, energy, mood and anxiety were assessed for both nights at 23:30 h, 01:30 h and 03:30 h using a visual analog scale (VAS). Subjective sleepiness was assessed with the Stanford Sleepiness Scale (SSS). Subjects also performed the Conners' Continuous Performance Test II (CPT-II) in order to assess objective alertness. Mixed model analysis was used to compare VAS, SSS and CPT-II parameters.


RESULTS
No difference between group A and group B was observed for subjective alertness, energy, mood, anxiety and sleepiness, as well as CPT-II parameters. Subjective alertness (p < 0.001), energy (p < 0.001) and sleepiness (p < 0.05) were, however improved after light exposure on the second night independently of the light condition.


CONCLUSIONS
The current study shows that when sleepiness is high, the alerting effect of light can still be triggered at night in the absence of short-wavelengths with a 30 minute light pulse of 500 μW/cm(2). This suggests that the underlying mechanism by which a brief polychromatic light exposure improves alertness is not solely due to short-wavelengths through intrinsically photosensitive retinal ganglion cells.
Adversarial Training for Relation Extraction

Adversarial training is a mean of regularizing classification algorithms by generating adversarial noise to the training data. We apply adversarial training in relation extraction within the multi-instance multi-label learning framework. We evaluate various neural network architectures on two different datasets. Experimental results demonstrate that adversarial training is generally effective for both CNN and RNN models and significantly improves the precision of pre-
Haptic Rendering: Introductory Concepts

In the last decade we have seen an enormous increase in interest in the science of haptics. The quest for better understanding and use of haptic abilities (both human and non-human) has manifested itself in heightened activity in disciplines broadly ranging from robotics and telerobotics, to computational geometry and computer graphics, to psychophysics, cognitive science and the neurosciences.
Endodontic or dental implant therapy: the factors affecting treatment planning.

BACKGROUND
Clinicians are confronted with difficult choices regarding whether a tooth with pulpal and/or periapical disease should be saved through endodontic treatment or be extracted and replaced with an implant.


METHODS
The authors examined publications (research, literature reviews and systematic reviews) related to the factors affecting decision making for patients who have oral diseases or traumatic injuries.


RESULTS
The factors to be considered included patient-related issues (systemic and oral health, as well as comfort and treatment perceptions), tooth- and periodontium-related factors (pulpal and periodontal conditions, color characteristics of the teeth, quantity and quality of bone, and soft-tissue anatomy) and treatment-related factors (the potential for procedural complications, required adjunctive procedures and treatment outcomes).


CONCLUSIONS
On the basis of survival rates, it appears that more than 95 percent of dental implants and teeth that have undergone endodontic treatment remain functional over time.


CLINICAL IMPLICATIONS
Clinicians need to consider carefully several factors before choosing whether to perform endodontic therapy or extract a tooth and place an implant. The result should be high levels of comfort, function, longevity and esthetics for patients.
Updates in lichen sclerosis: British Association of Dermatologists guidelines for the management of lichen sclerosus 2018.

s screened for eligibility according to protocol (n=894) References excluded by title (n=2086) References excluded by abstract (n=619) Papers included in quantitative review
Web-based instrument to assess skills in visual inspection of the cervix among healthcare providers.

OBJECTIVE
To validate a web-based instrument for assessing healthcare providers' skills in visual inspection with acetic acid or Lugol iodine (VIA/VILI) for the diagnosis and management of cervical intraepithelial neoplasia.


METHODS
An observational cross-sectional study enrolled healthcare providers in a web-based assessment of VIA/VILI skills between August and November 2014. Participants participated in a four-module training course, followed by a multiple-choice test with 70 questions based on cervical photographs of HPV-positive women participating in cervical screening. Logistic regression was used to identify relationships between independent variables and success on the test.


RESULTS
Overall, 255 participants completed the test and 99 (38.8%) passed. No correlation was found between age or sex and test performance. Compared with other healthcare workers, physicians (odds ratio [OR] 1.91, 95% confidence interval [CI] 1.01-3.63; P=0.048), and participants with more colposcopy experience (OR 3.62, 95% CI 1.91-6.85; P<0.001) and postgraduate VIA/VILI training (OR 1.95, 95% CI 1.16-3.29; P=0.012) were more likely to pass the test. Participants who repeated the test (31/255 [12.2%]) were five times more likely to succeed on their second repeat (OR 5.89, 95% CI 1.46-23.73; P=0.013).


CONCLUSION
Web-based training for VIA/VILI is feasible and can identify healthcare workers who are proficient in this technique.
Technical and economical considerations in the application of variable speed drives with electric motor systems

In the European Union (EU), Variable Speed Drives (VSDs) was identified as the motor systems technology having the most significant electricity savings potential. In the EU, the identified economic electricity savings potential with the application of VSDs, by 2015, in industrial and tertiary sectors are 39 TWh/year and 8 TWh/year, respectively. However, only a small percentage of this potential is being used. In this paper the characterization of current market of the VSDs is presented, including the average prices, the installation costs, and the total sales in each EU country, per power range. Selected VSD applications are presented. The key barriers to a wider application of VSDs are identified. In particular, the power quality and reliability problems associated with the use of VSDs are presented and possible technical solutions are discussed.
Introduction to the CoNLL-2002 Shared Task: Language-Independent Named Entity Recognition

We describe the CoNLL-2002 shared task: language-independent named entity recognition. We give background information on the data sets and the evaluation method, present a general overview of the systems that have taken part in the task and discuss their performance.
Light absorber with an ultra-broad flat band based on multi-sized slow-wave hyperbolic metamaterial thin-films

Here we realize a broadband absorber by using a hyperbolic metamaterial composed of alternating aluminum-alumina thin films based on superposition of multiple slow-wave modes. Our super absorber ensures broadband and polarization-insensitive light absorption over almost the entire solar spectrum, near-infrared and short-wavelength infrared regime (500–2500 nm) with a simulated absorption of over 90%. The designed structure is fabricated and the measured results are given. This absorber yields an average measured absorption of 85% in the spectrum ranging from 500 nm to 2300 nm. The proposed absorbers open an avenue towards realizing thermal emission and energyharvesting materials.
Working with UML: A software Design Process Based on Inspections for the Unified Modeling Language

This text describes a simple and effective object oriented software design process template having UML as the modeling language and extensively using inspections to support the construction and maintenance of software products. This software design process uses a sequential organization, based on the waterfall approach, for two reasons: to simplify the explanation of design activities in the context of All rights of reproduction in any form reserved. {Jobs}0774ap/makeup/774ch2.3d this text and to make available a standard process that can be continuously improved by developers. The component phases of this design process are described in a way that gives developers the freedom to reorganize the overall process based on their own needs and environment. In addition, a survey is provided of specific literature regarding important aspects of UML and the object oriented paradigm.
A decade of GPS in Southeast Asia: Resolving Sundaland motion and boundaries

[1] A unique GPS velocity field that spans the entire Southeast Asia region is presented. It is based on 10 years (1994–2004) of GPS data at more than 100 sites in Indonesia, Malaysia, Thailand, Myanmar, the Philippines, and Vietnam. The majority of the horizontal velocity vectors have a demonstrated global accuracy of 1 mm/yr (at 95% confidence level). The results have been used to (better) characterize the Sundaland block boundaries and to derive a new geokinematic model for the region. The rotation pole of the undeformed core of the Sundaland block is located at 49.0 N–94.2 E, with a clockwise rotation rate of 0.34 /Myr. With respect to both geodetically and geophysically defined Eurasia plate models, Sundaland moves eastward at a velocity of 6 ± 1 to 10 ± 1 mm/yr from south to north, respectively. Contrary to previous studies, Sundaland is shown to move independently with respect to South China, the eastern part of Java, the island of Sulawesi, and the northern tip of Borneo. The Red River fault in South China and Vietnam is still active and accommodates a strike-slip motion of 2 mm/yr. Although Sundaland internal deformation is general very small (less than 7 nanostrain/yr), important accumulation of elastic deformation occurs along its boundaries with fast-moving neighboring plates. In particular in northern Sumatra and Malaysia, inland-pointing trench-perpendicular residual velocities were detected prior to the megathrust earthquake of 26 December 2004. Earlier studies in Sumatra already showed this but underestimated the extent of the deformation zone, which reaches more than 600 km away from the trench. This study shows that only a regional Southeast Asia network spanning thousands of kilometers can provide a reference frame solid enough to analyze intraplate and interplate deformation in detail.
Face Identification with Bilinear CNNs

The recent explosive growth in convolutional neural network (CNN) research has produced a variety of new architectures for deep learning. One intriguing new architecture is the bilinear CNN (BCNN), which has shown dramatic performance gains on certain fine-grained recognition problems [13]. We apply this new CNN to the challenging new face recognition benchmark, the IARPA Janus Benchmark A (IJB-A) [10]. This is the first widely available public benchmark designed specifically to test face identification in real-world images. It features faces from a large number of identities in challenging real-world conditions. Because the face images were not identified automatically using a computer face detection system, it does not have the bias inherent in such a database. As a result, it includes variations in pose that are more challenging than many other popular benchmarks. In our experiments, we demonstrate the performance of the model trained only on ImageNet, then fine-tuned on the training set of IJB-A, and finally use a moderate-sized external database, FaceScrub [15]. Another feature of this benchmark is that that the testing data consists of collections of samples of a particular identity. We consider two techniques for pooling samples from these collections to improve performance over using only a single image, and we report results for both methods. Our application of this new CNN to the IJB-A results in gains over the published baselines of this new database.
NIHSS-time score easily predicts outcomes in rt-PA patients: The SAMURAI rt-PA registry

BACKGROUND
We aimed to devise a scale comprising a simple multiplication of initial National Institutes of Health Stroke Scale (NIHSS) score and onset-to-treatment time (OTT) as a scale for predicting outcomes after recombinant tissue plasminogen activator (rt-PA) therapy.


METHODS
Data from rt-PA patients in 10 stroke centers in Japan were investigated. NIHSS-time score was calculated as initial NIHSS score×OTT.


RESULTS
Subjects comprised 526 patients. Median NIHSS score was 12 (7-18), and median OTT was 2.42 h (2.00-2.75 h). Median NIHSS-time score was 27.7 (16.9-41.7). Good (modified Rankin Scale [mRS] 0-1) and poor (mRS 4-6) outcome rates at 3months for patients with NIHSS-time scores ≤ 10 were 71.1% and 7.8%, compared to 54.7% and 16.5% for scores >10 and ≤ 20, 38.9% and 31.9% for scores >20 and ≤ 30, 25.0% and 44.6% for scores >30 and ≤ 40, and 17.4% and 61.8% for scores >40, respectively. Cut-off NIHSS-time scores to predict good and poor outcomes with 50% probability were defined as 20 and 40, respectively. Multivariate logistic regression analysis revealed NIHSS-time score as an independent predictor of good (odds ratio [OR], 0.587; 95% confidence interval [CI], 0.422-0.818, p=0.002) and poor (OR, 1.756; 95%CI, 1.227-2.514, p=0.002) outcomes after adjusting for age, sex, NIHSS score, OTT, Alberta Stroke Program Early CT Score, internal carotid artery occlusion, and glucose level.


CONCLUSIONS
NIHSS-time score predicts clinical outcomes in rt-PA patients.