LLukas22/scidocs huggingface dataset:
The Effects of Centralised and Specialised Intervention in the Early Course of Severe Unipolar Depressive Disorder: A Randomised Clinical Trial

BACKGROUND
Little is known on whether centralised and specialised combined pharmacological and psychological intervention in the early phase of severe unipolar depression improve prognosis. The aim of the present study was to assess the benefits and harms of centralised and specialised secondary care intervention in the early course of severe unipolar depression.


METHODS
A randomised multicentre trial with central randomisation and blinding in relation to the primary outcome comparing a centralised and specialised outpatient intervention program with standard decentralised psychiatric treatment. The interventions were offered at discharge from first, second, or third hospitalisation due to a single depressive episode or recurrent depressive disorder. The primary outcome was time to readmission to psychiatric hospital. The data on re-hospitalisation was obtained from the Danish Psychiatric Central Register. The secondary and tertiary outcomes were severity of depressive symptoms according to the Major Depression Inventory, adherence to medical treatment, and satisfaction with treatment according to the total score on the Verona Service Satisfaction Scale-Affective Disorder (VSSS-A). These outcomes were assessed using questionnaires one year after discharge from hospital.


RESULTS
A total of 268 patients with unipolar depression were included. There was no significant difference in the time to readmission (unadjusted hazard ratio 0.89, 95% confidence interval 0.60 to 1.32; log rank: χ(2) = 0.3, d.f. = 1, p = 0.6); severity of depressive symptoms (mood disorder clinic: median 21.6, quartiles 9.7-31.2 versus standard treatment: median 20.2, quartiles 10.0-29.8; p = 0.7); or the prevalence of patients in antidepressant treatment (73.9% versus 80.0%, p = 0.2). Centralised and specialised secondary care intervention resulted in significantly higher satisfaction with treatment (131 (SD 31.8) versus 107 (SD 25.6); p<0.001).


CONCLUSIONS
Centralised and specialised secondary care intervention in the early course of severe unipolar depression resulted in no significant effects on time to rehospitalisation, severity of symptoms, or use of antidepressants, but increased patient satisfaction.


TRIAL REGISTRATION
ClinicalTrials.gov NCT00253071.
Increasing risk of asthma without other atopic diseases in school children: A repeated cross-sectional study after 13 years

Some children develop asthma and other atopic diseases, others asthma without atopic diseases. To better understand secular trends, we estimated the relative increase in asthma in children with (atopy related asthma) and without (non-atopy related asthma) other atopic diseases (eczema or hay fever) in two samples of school children born, 1965–1975 (n = 1674) and 1978–1988 (n = 2188). By analysing the samples as historical cohorts, age-specific prevalence rates were estimated and incidence rates were calculated (number of new cases by 1000 personyears under risk). Cox regression was used to estimate the relative risk (RR) of asthma by year of birth. The point prevalence of asthma was 1.9% (95% CI: 1.4–2.4) in the 1965–1975 cohort and 4.6% (95% CI: 3.8–5.4) in the 1978–1988 cohort for three-year old children, and remained fairly constant throughout childhood. The age-specific prevalence of non-atopy related asthma increased relatively more from 1965–1975 to 1978–1988 compared to atopy related asthma. The age-specific incidence rates of asthma showed that the RRs comparing the two cohorts tended at all ages to be highest for non-atopy related asthma. The relative risks of non-atopy related asthma by gender and birth cohort, showed that the effect of cohort was higher for non-atopy related asthma, aRR: 4.0 (95% CI: 2.5–6.5), than for atopy-related asthma aRR: 2.0 (95% CI: 1.3–3.2). Children without other atopic diseases have a higher relative risk of being diagnosed with asthma than children with other atopic diseases across all ages comparing two samples of school children born 1965–1975 and 1978–1988.
"I need to try this"?: a statistical overview of pinterest

Over the past decade, social network sites have become ubiquitous places for people to maintain relationships, as well as loci of intense research interest. Recently, a new site has exploded into prominence: Pinterest became the fastest social network to reach 10M users, growing 4000% in 2011 alone. While many Pinterest articles have appeared in the popular press, there has been little scholarly work so far. In this paper, we use a quantitative approach to study three research questions about the site. What drives activity on Pinterest? What role does gender play in the site's social connections? And finally, what distinguishes Pinterest from existing networks, in particular Twitter? In short, we find that being female means more repins, but fewer followers, and that four verbs set Pinterest apart from Twitter: use, look, want and need. This work serves as an early snapshot of Pinterest that later work can leverage.
Navigation Strategies for Exploring Indoor Environments

In this paper, we investigate safe and efficient map-building strategies for a mobile robot with imperfect control and sensing. In the implementation, a robot equipped with a range sensor builds a polygonal map (layout) of a previously unknown indoor environment. The robot explores the environment and builds the map concurrently by patching together the local models acquired by the sensor into a global map. A well-studied and related problem is the simultaneous localization and mapping (SLAM) problem, where the goal is to integrate the information collected during navigation into the most accurate map possible. However, SLAM does not address the sensorplacement portion of the map-building task. That is, given the map built so far, where should the robot go next? This is the main question addressed in this paper. Concretely, an algorithm is proposed to guide the robot through a series of “good” positions, where “good” refers to the expected amount and quality of the information that will be revealed at each new location. This is similar to the nextbest-view (NBV) problem studied in computer vision and graphics. However, in mobile robotics the problem is complicated by several issues, two of which are particularly crucial. One is to achieve safe navigation despite an incomplete knowledge of the environment and sensor limitations (e.g., in range and incidence). The other issue is the need to ensure sufficient overlap between each new local model and the current map, in order to allow registration of successive views under positioning uncertainties inherent to mobile robots. To address both issues in a coherent framework, in this paper we introduce the concept of a safe region, defined as the largest region that is guaranteed to be free of obstacles given the sensor readings made so far. The construction of a safe region takes sensor limitations into account. In this paper we also describe an NBV algorithm that uses the safe-region concept to select the next robot position at each step. The International Journal of Robotics Research Vol. 21, No. 10–11, October-November 2002, pp. 829-848, ©2002 Sage Publications The new position is chosen within the safe region in order to maximize the expected gain of information under the constraint that the local model at this new position must have a minimal overlap with the current global map. In the future, NBV and SLAM algorithms should reinforce each other. While a SLAM algorithm builds a map by making the best use of the available sensory data, an NBV algorithm, such as that proposed here, guides the navigation of the robot through positions selected to provide the best sensory inputs. KEY WORDS—next-best view, safe region, online exploration, incidence constraints, map building
Symbolic olfactory display

This thesis explores the problems and possibilities of computer-controlled scent output. I begin with a thorough literature review of how we smell and how scents are categorized. I look at applications of aroma through the ages, with particular emphasis on the role of scent in information display in a variety of media. I then present and discuss several projects I have built to explore the use of computer-controlled olfactory display, and some pilot studies of issues related to such display. I quantify human physical limitations on olfactory input, and conclude that olfactory display must rely on differences between smells, and not differences in intensity of the same smell. I propose a theoretical framework for scent in human-computer interactions, and develop concepts of olfactory icons and ‘smicons’. I further conclude that scent is better suited for display slowly changing, continuous information than discrete events. I conclude with my predictions for the prospects of symbolic, computer-controlled, olfactory display. Thesis Supervisor: Michael J. Hawley Assistant Professor of Media Arts & Sciences Funding provided by the sponsors of the Counter Intelligence Special Interest Group.
Maximum-likelihood estimation of circle parameters via convolution

The accurate fitting of a circle to noisy measurements of circumferential points is a much studied problem in the literature. In this paper, we present an interpretation of the maximum-likelihood estimator (MLE) and the Delogne-Kasa estimator (DKE) for circle-center and radius estimation in terms of convolution on an image which is ideal in a certain sense. We use our convolution-based MLE approach to find good estimates for the parameters of a circle in digital images. In digital images, it is then possible to treat these estimates as preliminary estimates into various other numerical techniques which further refine them to achieve subpixel accuracy. We also investigate the relationship between the convolution of an ideal image with a "phase-coded kernel" (PCK) and the MLE. This is related to the "phase-coded annulus" which was introduced by Atherton and Kerbyson who proposed it as one of a number of new convolution kernels for estimating circle center and radius. We show that the PCK is an approximate MLE (AMLE). We compare our AMLE method to the MLE and the DKE as well as the Crame/spl acute/r-Rao Lower Bound in ideal images and in both real and synthetic digital images.
Marketing metrics ' usage : Its predictors and implications for customer relationship management

a r t i c l e i n f o Keywords: Marketing metrics Customer relationship management Value-based organizational culture and processes Cross-functional conflict Innovative value proposition This research aims to determine the conditions that foster use of marketing metrics in customer relationship management (CRM) and identify the organizational factors that strengthen/weaken the impact of usage of marketing metrics on CRM performance. Based on the customer value-based theory of the firm and the contingency perspective, a research framework was developed to shed light on the predictor roles of customer value-based organizational culture and processes in determining usage of marketing metrics, and foster an understanding of the moderating roles of marketing-supply chain conflict, and innovative value proposition on the marketing metric-performance relationships. Empirical evidence from a sample of 209 business firms confirmed the main effect that customer value-based organizational culture and processes support a firm's use of marketing metrics that in turn enhance its CRM performance. Notable moderating effects were also identified. Although marketing-supply chain conflict weakens the impact of marketing metrics usage in achieving superior CRM performance, innovative value proposition strengthens the conversion of marketing-metric-related knowledge into superior CRM performance. Marketing metrics have received substantial attention from both managers and scholars in recent years. From a managerial perspective , top management increasingly calls for " marketing accountability " pressuring marketers to produce metrics that document marketing's ROI. From an academic perspective, the growing interest in marketing metrics can be attributable to five theoretical angles (Ambler, 2003). First, in line with control theory which suggests the need for ex-post information on marketing programs as an essential part of the cycle of analysis, planning, implementation and control (Jaworski, 1988; Kotler, 2003), marketing metrics are used to evaluate past performance to improve future strategy and execution. Second, in keeping with agency theory that focuses on contract between a principle and an agent and the need for ex-post data on the extent to which the principal's objectives have been met (Jensen & Meckling, 1976), marketing metrics could be used to document enforcement of the contract between corporate and functional (e.g. marketing) management (Ambler, Barwise, & Higson, 2001). Third, reinforcing the wider quest for a balanced scorecard of performance (Kaplan & Norton, 1996) which puts emphasis on such intangible assets as brand equity that account for a large and increasing proportion of shareholder value, marketing metrics are used to measure its various dimensions. Fourth, consistent …
Existing capacity to manage pharmaceuticals and related commodities in East Africa: an assessment with specific reference to antiretroviral therapy

BACKGROUND
East African countries have in the recent past experienced a tremendous increase in the volume of antiretroviral drugs. Capacity to manage these medicines in the region remains limited. Makerere University, with technical assistance from the USAID supported Rational Pharmaceutical Management Plus (RPM Plus) Program of Management Sciences for Health (MSH) established a network of academic institutions to build capacity for pharmaceutical management in the East African region. The initiative includes institutions from Uganda, Tanzania, Kenya and Rwanda and aims to improve access to safe, effective and quality-assured medicines for the treatment of HIV/AIDS, TB and Malaria through spearheading in-country capacity. The initiative conducted a regional assessment to determine the existing capacity for the management of antiretroviral drugs and related commodities.


METHODS
Heads and implementing workers of fifty HIV/AIDS programs and institutions accredited to offer antiretroviral services in Uganda, Kenya, Tanzania and Rwanda were key informants in face-to-face interviews guided by structured questionnaires. The assessment explored categories of health workers involved in the management of ARVs, their knowledge and practices in selection, quantification, distribution and use of ARVs, nature of existing training programs, training preferences and resources for capacity building.


RESULTS
Inadequate human resource capacity including, inability to select, quantify and distribute ARVs and related commodities, and irrational prescribing and dispensing were some of the problems identified. A competence gap existed in all the four countries with a variety of healthcare professionals involved in the supply and distribution of ARVs. Training opportunities and resources for capacity development were limited particularly for workers in remote facilities. On-the-job training and short courses were the preferred modes of training.


CONCLUSION
There is inadequate capacity for managing medicines and related commodities in East Africa. There is an urgent need for training in aspects of pharmaceutical management to different categories of health workers. Skills building activities that do not take healthcare workers from their places of work are preferred.
Longitudinal study of symptoms and cognitive function in chronic schizophrenia

There is conflicting evidence of a relationship between changes in symptoms and cognitive functioning in schizophrenia. This study investigated longitudinal changes in psychopathology and cognitive functioning in chronic schizophrenia utilising three different dimensional models of symptomatology. Sixty-two patients diagnosed with DSM-IV schizophrenia or schizoaffective disorder were examined on two occasions over a period of 6 months for symptom improvement, measured by Positive and Negative Syndrome Scale (PANSS) [Kay et al., Schizophr. Bull. 13 (1987) 261]. Participants also completed a comprehensive battery of neuropsychological tasks designed to assess attention, verbal and non-verbal memory, psychomotor processing and executive/frontal functioning on both occasions. Twenty-five control subjects were assessed for comparison purposes. Severity of negative symptoms predicted poor neuropsychological performance on IQ, verbal fluency and memory measures at occasion one. However, using regression analyses, significant improvements in symptom ratings over time using two-, three- or five-dimensional models did not predict improvements in any aspect of cognitive functioning measured, except motor speed. The results do not suggest a causal relationship between the course of symptoms and neuropsychological functioning in chronic schizophrenia.
Flux-weakening control strategy of separately excited DC machine utilizing voltage regulation for modifying field current

This paper proposes a new approach flux-weakening control strategy of the separately excited DC machine. The proposed method is based on the closed-loop speed control in which the field current is independently controlled to adjust the flux-linkage in the flux-weakening operation. In order to achieve the maximum torque in the constant-torque region, the maximum field current is employed, while it is gradually modified in the constant-power region, following the increased speed, by the voltage regulation part. The modification current is determined based on the utilization of the difference voltages between command and voltage limit of DC-DC converter. The proposed method exhibits advantages such as high torque at low speed, wider operating speed range, robustness against machine parameters, and high efficiency in the constant-power region rather than without flux-weakening control. The effectiveness of the proposed method is verified by simulation results.
Les Sud‐américains de Paris: Latin American Artists and Cultural Resistance in Robho Magazine

Abstract Edited in Paris between 1967 and 1971 by the art critic Jean Clay and the visual poet Julien Blaine, Robho magazine introduced an international view of art. The magazine aimed to shed light on institutional critique and cultural resistance to American‐style capitalist expansion. To this end Robho included a significant number of Latin American artists. With graphic design by Carlos Cruz‐Diez, many of the magazine’s central articles were devoted to Madi art, Jesus Rafael Soto, Julio Le Parc, Lygia Clark and the Argentine collective experience Tucuman Arde. If the aforementioned artists were neither political exiles nor guerrilla fighters it may be thought, though, that being Latin American carried particular connotations within the context of the crisis of French modernisation in the 1960s, related to the imaginary of the Third World. This article aims to analyse Robho magazine’s selection and interpretation of the work of Latin American artists during this period dominated by the events of May 19...
Comparison of 2 Orthotic Approaches in Children With Cerebral Palsy.

PURPOSE
To compare dynamic ankle-foot orthoses (DAFOs) and adjustable dynamic response (ADR) ankle-foot orthoses (AFOs) in children with cerebral palsy.


METHODS
A total of 10 children with cerebral palsy (4-12 years; 6 at Gross Motor Function Classification System level I, 4 at Gross Motor Function Classification System level III) and crouch and/or equinus gait wore DAFOs and ADR-AFOs, each for 4 weeks, in randomized order. Laboratory-based gait analysis, walking activity monitor, and parent-reported questionnaire outcomes were compared among braces and barefoot conditions.


RESULTS
Children demonstrated better stride length (11-12 cm), hip extension (2°-4°), and swing-phase dorsiflexion (9°-17°) in both braces versus barefoot. Push-off power (0.3 W/kg) and knee extension (5°) were better in ADR-AFOs than in DAFOs. Parent satisfaction and walking activity (742 steps per day, 43 minutes per day) were higher for DAFOs.


CONCLUSIONS
ADR-AFOs produce better knee extension and push-off power; DAFOs produce more normal ankle motion, greater parent satisfaction, and walking activity. Both braces provide improvements over barefoot.
Ultradeep sequencing study of chronic hepatitis C virus genotype 1 infection in patients treated with daclatasvir, peginterferon, and ribavirin.

Direct-acting antivirals (DAAs) are either part of the current standard of care or are in advanced clinical development for the treatment of patients chronically infected with hepatitis C virus (HCV) genotype 1, but concern exists with respect to the patients who fail these regimens with emergent drug-resistant variants. In the present study, ultradeep sequencing was performed to analyze resistance to daclatasvir (DCV), which is a highly selective nonstructural protein 5A (NS5A) inhibitor. Eight patients with HCV genotype 1b, who were either treatment naive or prior nonresponders to pegylated interferon plus ribavirin (Rebetol; Schering-Plough) (PEG-IFN/RBV) therapy, were treated with DCV combined with PEG-IFN alpha-2b (Pegintron; Schering-Plough, Kenilworth, NJ) and RBV. To identify the cause of viral breakthrough, the preexistence and emergence of DCV-resistant variants at NS5A amino acids were analyzed by ultradeep sequencing. Sustained virological response (SVR) was achieved in 6 of 8 patients (75%), with viral breakthrough occurring in the other 2 patients (25%). DCV-resistant variant Y93H preexisted as a minor population at higher frequencies (0.1% to 0.5%) in patients who achieved SVR. In patients with viral breakthrough, DCV-resistant variant mixtures emerged at NS5A-31 over time that persisted posttreatment with Y93H. Although enrichment of DCV-resistant variants was detected, the preexistence of a minor population of the variant did not appear to be associated with virologic response in patients treated with DCV/PEG-IFN/RBV. Ultradeep sequencing results shed light on the complexity of DCV-resistant quasispecies emerging over time, suggesting that multiple resistance pathways are possible within a patient who does not rapidly respond to a DCV-containing regimen. (This study has been registered at ClinicalTrials.gov under registration no. NCT01016912.).
Understanding success and failure in customer relationship management

Customer Relationship Management (CRM) systems can help organizations manage customer interactions more effectively. Like many new technologies, CRM has been accompanied by vendor hype and stories of implementation failure. Work on critical success factors (CSFs) should encourage more appropriate implementation practice; however many CSF studies conclude with a list of factors but provide little further guidance. In particular, there is a need for stronger theoretical models of the entire CRM innovation process which can be used by managers to understand better the underlying causes of success and failure. This paper adopts a novel approach to this problem by firstly developing a conceptual model of CRM innovation and then converting this model into a dynamic simulation model. Some early simulation results illustrating changes in CRM benefits and organizational support over time are presented together with a discussion of the underlying causes and suggestions for how managers can counteract potential innovation failure. © 2007 Elsevier Inc. All rights reserved.