LLukas22/scidocs huggingface dataset:
Citalopram therapy for depression: a review of 10 years of European experience and data from U.S. clinical trials.

BACKGROUND
This review summarizes and evaluates clinical experience with citalopram, the latest selective serotonin reuptake inhibitor (SSRI) to be approved for the treatment of depression in the United States.


DATA SOURCES
Published reports of randomized, double-blind, controlled clinical studies of citalopram were retrieved using a MEDLINE literature search. Search terms included citalopram, SSRI, TCA (tricylic antidepressant), depression, and clinical. For each study, data on antidepressant efficacy and adverse events were evaluated. Pharmacokinetic studies and case reports were reviewed to supplement the evaluation of citalopram's safety and tolerability. Data presented at major medical conferences and published in abstract form also were reviewed.


STUDY FINDINGS
Thirty randomized, double-blind, controlled studies of the antidepressant efficacy of citalopram were located and reviewed. In 11 studies, citalopram was compared with placebo (1 of these studies also included comparison with another SSRI). In 4 additional studies, the efficacy of citalopram in preventing depression relapse or recurrence was investigated. In another 11 studies (including 1 meta-analysis of published and unpublished trials), citalopram was compared with tricyclic and tetracyclic antidepressants. Finally, results are available from 4 studies in which citalopram was compared with other SSRIs. A placebo-controlled study of citalopram for the treatment of panic disorder was reviewed for data on long-term adverse events.


CONCLUSION
Data published over the last decade suggest that citalopram is (1) superior to placebo in the treatment of depression, (2) has efficacy similar to that of the tricyclic and tetracyclic antidepressants and to other SSRIs, and (3) is safe and well tolerated in the therapeutic dose range of 20 to 60 mg/day. Distinct from some other agents in its class, citalopram exhibits linear pharmacokinetics and minimal drug interaction potential. These features make citalopram an attractive agent for the treatment of depression, especially among the elderly and patients with comorbid illness.
Ketogenic diet does not affect strength performance in elite artistic gymnasts

BACKGROUND
Despite the increasing use of very low carbohydrate ketogenic diets (VLCKD) in weight control and management of the metabolic syndrome there is a paucity of research about effects of VLCKD on sport performance. Ketogenic diets may be useful in sports that include weight class divisions and the aim of our study was to investigate the influence of VLCKD on explosive strength performance.


METHODS
8 athletes, elite artistic gymnasts (age 20.9 ± 5.5 yrs) were recruited. We analyzed body composition and various performance aspects (hanging straight leg raise, ground push up, parallel bar dips, pull up, squat jump, countermovement jump, 30 sec continuous jumps) before and after 30 days of a modified ketogenic diet. The diet was based on green vegetables, olive oil, fish and meat plus dishes composed of high quality protein and virtually zero carbohydrates, but which mimicked their taste, with the addition of some herbal extracts. During the VLCKD the athletes performed the normal training program. After three months the same protocol, tests were performed before and after 30 days of the athletes' usual diet (a typically western diet, WD). A one-way Anova for repeated measurements was used.


RESULTS
No significant differences were detected between VLCKD and WD in all strength tests. Significant differences were found in body weight and body composition: after VLCKD there was a decrease in body weight (from 69.6 ± 7.3 Kg to 68.0 ± 7.5 Kg) and fat mass (from 5.3 ± 1.3 Kg to 3.4 ± 0.8 Kg p < 0.001) with a non-significant increase in muscle mass.


CONCLUSIONS
Despite concerns of coaches and doctors about the possible detrimental effects of low carbohydrate diets on athletic performance and the well known importance of carbohydrates there are no data about VLCKD and strength performance. The undeniable and sudden effect of VLCKD on fat loss may be useful for those athletes who compete in sports based on weight class. We have demonstrated that using VLCKD for a relatively short time period (i.e. 30 days) can decrease body weight and body fat without negative effects on strength performance in high level athletes.
Footprint of uncertainty for type-2 fuzzy sets

In the paper, a new and comprehensible definition is proposed for type-2 fuzzy sets (T2 FSs), and the primary and secondary memberships function are defined respectively by using multi valued mapping. A new definition and formula for the footprint of uncertainty (FOU) is presented, and based on the new definitions, the relation between FOU and the original definition of T2 FS is discussed. Finally, the partition method of FOU is provided to represent the primary membership grade, the FOU and the interval type-2 fuzzy sets (IT2 FS) when the upper and lower membership functions (UMF, LMF) of FOU are given. 2014 Elsevier Inc. All rights reserved.
A Micro-Spatial Analysis of the Demographic and Criminogenic Environment of Drug Markets in Philadelphia

THE AUSTRALIAN AND NEW ZEALAND JOURNAL OF CRIMINOLOGY VOLUME 40 NUMBER 1 2007 PP. 43–63 Address for correspondence: Jerry H. Ratcliffe, Associate Professor, Department of Criminal Justice, Gladfelter Hall, Temple University, 1115 W Berks Street, Philadelphia PA 19122, United States of America. E-mail: jhr@temple.edu A Micro-Spatial Analysis of the Demographic and Criminogenic Environment of Drug Markets in Philadelphia
A Discriminative Graph-Based Parser for the Abstract Meaning Representation

Abstract Meaning Representation (AMR) is a semantic formalism for which a growing set of annotated examples is available. We introduce the first approach to parse sentences into this representation, providing a strong baseline for future improvement. The method is based on a novel algorithm for finding a maximum spanning, connected subgraph, embedded within a Lagrangian relaxation of an optimization problem that imposes linguistically inspired constraints. Our approach is described in the general framework of structured prediction, allowing future incorporation of additional features and constraints, and may extend to other formalisms as well. Our open-source system, JAMR, is available at:Meaning Representation (AMR) is a semantic formalism for which a growing set of annotated examples is available. We introduce the first approach to parse sentences into this representation, providing a strong baseline for future improvement. The method is based on a novel algorithm for finding a maximum spanning, connected subgraph, embedded within a Lagrangian relaxation of an optimization problem that imposes linguistically inspired constraints. Our approach is described in the general framework of structured prediction, allowing future incorporation of additional features and constraints, and may extend to other formalisms as well. Our open-source system, JAMR, is available at: http://github.com/jflanigan/jamr
Direct torque control of induction machines with constant switching frequency and reduced torque ripple

Direct torque control (DTC) of induction machines is known to have a simple control structure with comparable performance to that of the field-oriented control technique. Two major problems that are usually associated with DTC drives are: switching frequency that varies with operating conditions and high torque ripple. To solve these problems, and at the same time retain the simple control structure of DTC, a constant switching frequency torque controller is proposed to replace the conventional hysteresis-based controller. In this paper, the modeling, averaging, and linearization of the torque loop containing the proposed controller followed by simulation and experimental results are presented. The proposed controller is shown to be capable of reducing the torque ripple and maintaining a constant switching frequency.
Driven coherent oscillations of a single electron spin in a quantum dot

The ability to control the quantum state of a single electron spin in a quantum dot is at the heart of recent developments towards a scalable spin-based quantum computer. In combination with the recently demonstrated controlled exchange gate between two neighbouring spins, driven coherent single spin rotations would permit universal quantum operations. Here, we report the experimental realization of single electron spin rotations in a double quantum dot. First, we apply a continuous-wave oscillating magnetic field, generated on-chip, and observe electron spin resonance in spin-dependent transport measurements through the two dots. Next, we coherently control the quantum state of the electron spin by applying short bursts of the oscillating magnetic field and observe about eight oscillations of the spin state (so-called Rabi oscillations) during a microsecond burst. These results demonstrate the feasibility of operating single-electron spins in a quantum dot as quantum bits.
PZT ceramics formed directly from oxides via reactive sintering

Abstract Lead zicronate titanate ceramics with morphological boundary phase (PMP) composition (PbZr 0.52 Ti 0.48 O 3 or PZT) were prepared directly from their oxide mixture without involving calcination process. Sintering behavior of the oxide mixture showed that there was a volumetric expansion occurring at about 800°C, which can be attributed to the reaction to PZT compound from the oxide mixture. A maximum sintering rate was observed at about 870°C in the linear sintering rate curve, showing that the densification of the oxide mixture is significant than that of calcined powder. PZT ceramics sintered at 1100°C for 1 h demonstrated a dielectric constant of 1157 at 1 kHz, a remnant polarization of 27.3 μC/cm 2 and coercive field of 21 kV/cm, respectively.
Sustainability principles and their integration into a higher education mechanical engineering undergraduate programme

Current undergraduate engineering programs tend to be organised along fairly standard 
engineering themes such as mechanical engineering or automotive engineering. The engineering institutions have made it plain that sustainability needs to be a fundamental 
element of all mechanical engineering themed courses yet in reality only a tiny minority 
of modules make reference to sustainability. It is true, however that sustainability is a 
subject with such a large depth and breadth that the subject could be dedicated to whole degree courses. This paper defines the Principles of Sustainability [4] and suggests several types of degree program through which sustainability can be introduced into a higher education, undergraduate mechanical engineering scheme. The paper explains that sustainability can only be taught through the medium of design since the design function is the only function which has an overview and can influence the life of a 
product from "cradle to grave".
Randomized, double-blind study of the analgesic efficacy of morphine-6-glucuronide versus morphine sulfate for postoperative pain in major surgery.

BACKGROUND
Morphine-6-glucuronide (M6G) has promising preclinical characteristics and encouraging pharmacokinetic features for acute nociceptive pain. Early studies have produced a good safety profile when compared to morphine sulfate, although in surrogate pain models studies, a mixed picture emerged. A study to evaluate the efficacy and safety profile in a clinical setting was designed.


METHODS
The authors conducted a double-blind, randomized, dose-finding study of patients scheduled to undergo major joint replacement. One hundred patients of both sexes were included, with 50 patients in each group. A loading dose of 10 mg of study medication was given intravenously at induction of anesthesia, and two further doses were allowed during surgery if required. Bolus doses via a patient-controlled analgesia system were given subcutaneously at 2 mg/dose and set at a 10-min lockout. Assessments of pain intensity and relief were recorded during the 24-h period.


RESULTS
There were no statistically significant differences between the treatments for 24-h mean pain intensity. However, pain intensity was significantly higher in the M6G group than in the morphine group at 30 min and 1 h. There was no statistical difference in 24-h mean pain relief or retrospective pain scores at any time point during the 24-h period. The severity of sedation was significantly greater in the morphine group than in the M6G group at 30 min, 1 h, 2 h, and 24 h. Respiratory depression was greater in the morphine group than in the M6G group, and more patients in the morphine group withdrew from the study because of respiratory depression.


CONCLUSIONS
Overall, M6G has an analgesic effect similar to that of morphine over the first 24 h postoperatively. However, M6G may be slower onset initially than morphine; therefore, a larger initial dose may be required.
An association analysis of lipid profile and diabetic cardiovascular autonomic neuropathy in a Chinese sample

Recent studies have shown that triglyceride (TG), low-density lipoprotein cholesterol (LDL), and high-density lipoprotein cholesterol (HDL) are related to the prevalence of cardiovascular autonomic neuropathy (CAN). However, little is known about the association of lipid profile with diabetic cardiovascular autonomic neuropathy (DCAN), or its severity in the Chinese population. The purpose of this study is to explore the extent of this phenomenon using a Chinese sample. A subgroup analysis on 455 diabetic patients with undiagnosed DCAN was performed to evaluate the relationships of lipids profile and DCAN. DCAN was diagnosed if there were at least two abnormal cardiovascular autonomic reflex test results, based on short-term heart rate variability tests. Multivariable logistic regression (MLR)was carried out to control potential confounders for determining the independent association of variables with DCAN in different models. MLR analysis indicated that TG was significantly and independently associated with DCAN when controlling for confounding factors (P < 0.1 for two models). Additionally, TG combined with TC (LRS-1) and LDL (LRS-2) was associated with this outcome (P < 0.1 for LRS-1 and LRS-2). Our findings indicate that TG and the severity of lipids profile is significantly and independently associated with DCAN, respectively. ClinicalTrials.gov Identifier: NCT02461472 , retrospectively registered 2 Jun, 2015
Open-label phase I trial of vandetanib in combination with mFOLFOX6 in patients with advanced colorectal cancer

Background: Vandetanib (ZACTIMA™) is a once-daily oral inhibitor of vascular endothelial growth factor, epidermal growth factor and RET receptor tyrosine kinases. The safety and tolerability of vandetanib plus mFOLFOX6 was investigated in patients with advanced colorectal cancer (CRC). Methods: Patients eligible for first- or second-line chemotherapy received once-daily oral doses of vandetanib (100 or 300 mg) plus 14-day treatment cycles of mFOLFOX6. Results: Seventeen patients received vandetanib 100 mg (n = 9) or 300 mg (n = 8) plus mFOLFOX6. The protocol definition of a tolerable dose (vandetanib-related dose-limiting toxicity [DLT] in less than two patients) was met in both dose cohorts, with one DLT of diarrhoea reported in each. Overall, the most common adverse events were diarrhoea, nausea and lethargy (all n = 11). There was no pharmacokinetic interaction between vandetanib and mFOLFOX6. Preliminary efficacy results included one complete response and three confirmed partial responses. Conclusions: In patients with advanced CRC, once-daily vandetanib (100 or 300 mg) with mFOLFOX6 was generally well tolerated.
Trading Volume and Serial Correlation in Stock Returns

This paper investigates the relationship between aggregate stock market trading volume and the serial correlation of daily stock returns. For both stock indexes and individual large stocks, the first-order daily return autocorrelation tends to decline with volume. The paper explains this phenomenon using a model in which risk-averse "market makers" accommodate buying or selling pressure from "liquidity" or "noninformational" traders. Changing expected stock returns reward market makers for playing this role. The model implies that a stock price decline on a high-volume day is more likely than a stock price decline on a low-volume day to be associated with an increase in the expected stock return.
Modernism, Race and Manifestos: Contents

1. Introduction: manifestos, race, and modernity Part I. Cosmopolitan London, 1906-14: 2. Women's suffrage melodrama and burlesque 3. Futurism's music hall and India docks 4. Vorticism's cabaret modernism and racial spectacle Part II. Transnational Modernisms, 1934-8: 5. Nancy Cunard's negro and black transnationalism 6. Reading across the Color Line: Virginia Woolf, C. L. R. James, and Suzanne and Aime Cesaire Epilogue: manifestos: then and now Index.
CSR and financial performance: The role of CSR awareness in the restaurant industry

Initiatives for corporate social responsibility (CSR) often have served business as a source of competitive advantage. However, despite firms’ attempts to capitalize on their CSR efforts, stakeholders’ low awareness of these initiatives makes it difficult to realize the full value of the strategic CSR. In this study, we propose and test in the context of the restaurant industry whether CSR awareness, measured by CSR media coverage, moderates the relationship between the social and financial performance. Our results support the notion that stakeholders’ CSR awareness affects the manner in which CSR initiatives can result in financial gain. Our research has implications both for firms’ investment policies in social initiatives and for highlighting the importance of communicating CSR initiatives to relevant stakeholders. © 2016 Elsevier Ltd. All rights reserved.
Effects of home-based exercise training for patients with chronic heart failure and sleep apnoea: a randomized comparison of two different programmes.

OBJECTIVE
To evaluate the effects of home-based exercise for patients with chronic heart failure and sleep apnoea and to compare two different training programmes.


DESIGN
A randomized, prospective controlled trial.


SETTING
Department of Cardiology, University Hospital, Brazil.


SUBJECTS
Fifty chronic heart failure patients with sleep apnoea were randomized in three groups: Group 1 (aerobic training, n = 18), Group 2 (aerobic with strength training, n = 18), and Group 3 (untrained, n = 14).


INTERVENTIONS
The training programme for Groups 1 and 2 began with three supervised exercise sessions, after they underwent three months of home-based exercise. Patients were followed by weekly telephone call and were reviewed monthly. Group 3 had the status of physical activity evaluated weekly by interview to make sure they remained untrained.


MAIN OUTCOME MEASURES
At baseline and after three months: cardiopulmonary exercise testing, isokinetic strength and endurance, Minnesota living with heart failure questionnaire and polysomnography. Adherence was evaluated weekly.


RESULTS
Of the 50 patients enrolled in the study, 45 completed the programme. Clinical events: Group 1 (one death), Group 2 (one myocardial infarction), Group 3 (one death and two strokes). None were training related. Training groups showed improvement in all outcomes evaluated and the adherence was an important factor (Group 1 = 98.5% and Group 2 = 100.2%, P = 0.743). Untrained Group 3 demonstrated significant decrease or no change on measurements after three months without training.


CONCLUSION
Home-based exercise training is an important therapeutic strategy in chronic heart failure patients with sleep apnoea, and strength training resulted in a higher increase in muscle strength and endurance.
Necessity for surgical revision of defibrillator leads implanted long-term: causes and management.

BACKGROUND
Defibrillator lead malfunction is a potential long-term complication in patients with an implantable cardioverter-defibrillator (ICD). The aim of this study was to determine the incidence and causes of lead malfunction necessitating surgical revision and to evaluate 2 approaches to treat lead malfunction.


METHODS AND RESULTS
We included 1317 consecutive patients with an ICD implanted at 3 European centers between 1993 and 2004. The types and causes of lead malfunction were recorded. If the integrity of the high-voltage part of the lead could be ascertained, an additional pace/sense lead was implanted. Otherwise, the patients received a new ICD lead. Of the 1317 patients, 38 experienced lead malfunction requiring surgical revision and 315 died during a median follow-up of 6.4 years. At 5 years, the cumulative incidence was 2.5% (95% confidence interval, 1.5 to 3.6). Lead malfunction resulted in inappropriate ICD therapies in 76% of the cases. Implantation of a pace/sense lead was feasible in 63%. Both lead revision strategies were similar with regard to lead malfunction recurrence (P=0.8). However, the cumulative incidence of recurrence was high (20% at 5 years; 95% confidence interval, 1.7 to 37.7).


CONCLUSIONS
ICD lead malfunction necessitating surgical revision becomes a clinically relevant problem in 2.5% of ICD recipients within 5 years. In selected cases, simple implantation of an additional pace/sense lead is feasible. Regardless of the chosen approach, the incidence of recurrent ICD lead-related problems after lead revision is 8-fold higher in this population.
Prognostic influence of Barrett's oesophagus and Helicobacter pylori infection on healing of erosive gastro-oesophageal reflux disease (GORD) and symptom resolution in non-erosive GORD: report from the ProGORD study.

BACKGROUND
Adequacy of acid suppression is a critical factor influencing healing in gastro-oesophageal reflux disease (GORD). The European prospective study ProGORD was set up to determine the endoscopic and symptomatic progression of GORD over five years under routine care, after initial acid suppression with esomeprazole. We report on factors influencing endoscopic healing and symptom resolution during the acute treatment phase.


METHODS
Patients with symptoms suggestive of GORD underwent endoscopy and biopsies were obtained from the oesophagus for diagnosis of abnormalities, including Barrett's oesophagus (BO). Data from 6215 patients were included in the "intention to treat" analysis, 3245 diagnosed as having erosive reflux disease (ERD) and 2970 non-erosive reflux disease (NERD). ERD patients were treated with esomeprazole 40 mg for 4-8 weeks for endoscopic healing while NERD patients received 20 mg for 2-4 weeks for resolution of heartburn symptoms.


RESULTS
Endoscopic healing occurred overall in 87.7% of ERD patients although healing was significantly lower in those with more severe oesophagitis (76.9%) and in those with BO (72.4%), particularly in Helicobacter pylori negative BO patients (70.1%). Age, sex, and body mass index appeared to have no significant impact on healing. Complete heartburn resolution was reported by 70.4% of ERD patients and by 64.8% of NERD patients at the last visit. Only H pylori infection had a significant influence on complete heartburn resolution in the NERD group (68.1% and 63.7% for H pylori positive and H pylori negative, respectively; p = 0.03).


CONCLUSION
The presence of Barrett's mucosa, as well as severe mucosal damage, exerts a negative impact on healing. H pylori infection had a positive influence on healing in ERD patients with coexistent BO but no influence on those without BO.