LLukas22/scidocs huggingface dataset:
Bridging the divide between families and health professionals' perspectives on family-centred care.

OBJECTIVES
To describe and discuss key findings from a recent research project that challenge an increasingly prevalent theme, apparent in both family-centred care research and practice, of conceptualizing family-centred care as shifting care, care management, and advocacy responsibilities to families. The purpose of the research, from which these findings emerged, was to develop a conceptualization of family-centred care grounded in the experiences of families and direct health-care providers.


DESIGN
Qualitative research methods, following the grounded theory tradition, were used to develop a conceptual framework that described the dimensions of the concept of family-centred care and their interrelationships, in the substantive area of children's developmental services. This article reports on and extends key findings from this grounded theory study, in light of current trends in the literature.


SETTING AND PARTICIPANTS
The substantive area that served as the setting for the research was developmental services at a children's hospital in Alberta, Canada. Data was collected through focus groups and individual interviews with 37 parents of children diagnosed with a developmental problem and 16 frontline health-care providers.


FINDINGS
Key findings from this research project do not support the current emphasis in family-centred care research and practice on conceptualizing family-centred care as the shifting of care, care management, and advocacy responsibilities to families. Rather, what emerged was that parents want to work truly collaboratively with health-care providers in making treatment decisions and on implementing a dynamic care plan that will work best for child and family.


DISCUSSION AND CONCLUSIONS
A definition of collaboration is provided, and the nature of collaborative relationships described. Contributing factors to the difficulty in establishing true collaborative relationships between families and health-care professionals, where the respective roles to be played by health-care professionals and families are jointly determined, are discussed. In light of these findings we strongly advocate for the re-examination of current family-centred care policy and practice.
A Virtual Impedance Comprehensive Control Strategy for the Controllably Inductive Power Filtering System

In this letter, a virtual impedance comprehensive control (VICC) strategy is proposed for the controllably inductive power filtering (CIPF) system with a new filtering mechanism. This control strategy aims to satisfy the zero-impedance design precondition of the inductive power filtering system, and can dampen the harmonic resonance at the grid side. By the proposed zero-impedance control, the quality factor of the passive power device can be adjustable, and the single-tuned filter can be multituned. First, the main circuit topology for implementing the VICC-based CIPF is presented. Then, on the basis of the multipurpose control, the VICC strategy is designed. Furthermore, by means of the established equivalent circuit model and the corresponding mathematical model, the principles of the harmonic damping and the zero-impedance realization are revealed. Finally, the experimental results verify that the proposed control strategy can weaken the harmonic amplification effectively, and improve the filtering performance significantly.
No resistance to tenofovir disoproxil fumarate detected after up to 144 weeks of therapy in patients monoinfected with chronic hepatitis B virus.

UNLABELLED
Tenofovir disoproxil fumarate (TDF) is a nucleotide analogue with potent activity against human immunodeficiency virus type 1 and hepatitis B virus (HBV). To date, no reports of HBV clinical resistance to TDF have been confirmed. In two phase 3 studies (GS-US-174-0102 and GS-US-174-0103), 375 hepatitis B e antigen-negative (HBeAg(-) ) patients and 266 HBeAg(+) patients with chronic hepatitis B (some nucleoside-naive and some lamivudine-experienced) were randomized 2:1 to receive TDF (n = 426) or adefovir dipivoxil (ADV; n = 215) for 48 weeks. After week 48, eligible patients received open-label TDF with no interruption. The studies are being continued through week 384/year 8; week 144 data are presented here. Per protocol, viremic patients (HBV DNA level ≥ 400 copies/mL or 69 IU/mL) had the option of adding emtricitabine (FTC) at or after week 72. Resistance analyses of HBV polymerase/reverse transcriptase (pol/RT) were based on population dideoxy sequencing. Phenotypic analyses were conducted in HepG2 cells with recombinant HBV derived from patient serum. Most patients maintained TDF monotherapy treatment across both studies (607/641, 95%). A resistance analysis of HBV pol/RT was performed at the baseline for all patients, for viremic patients at week 144 or at the last time when they were on TDF monotherapy (34 on TDF and 19 on ADV-TDF), and for patients who remained viremic after the addition of FTC (7/20 on TDF and 5/14 on ADV-TDF). No patient developed amino acid substitutions associated with resistance to TDF. Virological breakthrough on TDF monotherapy was infrequent over 144 weeks (13/426, 3%) and was attributed to documented nonadherence in most cases (11/13, 85%). Persistent viremia (≥400 copies/mL) through week 144 was rare (5/641, 0.8%) and was not associated with virological resistance to TDF by population or clonal analyses.


CONCLUSION
No nucleoside-naive or nucleoside-experienced patient developed HBV pol/RT mutations associated with TDF resistance after up to 144 weeks of exposure to TDF monotherapy.
Prevalence of cardiovascular disease risk factors among Egyptian and Saudi medical students: a comparative study.

BACKGROUND
Results from recent reports suggest that the mortality and the morbidity from coronary heart disease (CHD) is leveling, especially in younger adults. Studies conducted in both Saudi Arabia and Egypt, aiming at the estimation of the prevalence of cardiovascular risk factors among the young population, demonstrated a high prevalence of risk factors.


OBJECTIVE
The aim of this study was to compare the prevalence of cardiovascular risk factors among medical students aged 18-25 years in two Middle East countries (Egypt and Saudi Arabia).


PARTICIPANTS AND METHODS
This was a cross-sectional comparative study involving a sample of 360 medical students of both sexes randomly selected from students enrolled into two medical colleges in Saudi Arabia and Egypt.


RESULTS
The prevalence of risk factors for cardiovascular disease was relatively high among both Saudi and Egyptian medical students, particularly a sedentary life style, obesity, and abdominal obesity. Smoking was practiced by 29.7% of both populations. A significantly higher prevalence of obesity and a reported family history of premature CHD were observed among the Saudi students and a significantly higher prevalence of hypertension was found among male Egyptian students as compared with male Saudi students. A relatively high proportion of both populations (23.9% of Saudi students and 16.7% of the Egyptian students) was at an increased risk of developing fatal cardiovascular disease within 10 years.


CONCLUSION
Apart from the higher prevalence of obesity and reported family history of premature CHD among the Saudi students and the significantly higher prevalence of hypertension among the Egyptian students, there was no statistically significant difference between the risk profiles of both populations. Participatory behavior change programs in medical schools for the adoption of healthy lifestyles, particularly involvement in regular physical activity and smoking cessation are highly recommended.
Maximum likelihood estimation for conditional distribution single-index models under censoring

A new likelihood approach is proposed for the problem of semiparametric estimation of a conditional distribution or density under censoring. Consistency and asymptotic normality for two versions of the maximum likelihood estimator of the parameter vector in the single index model are proved. The single-index model considered can be seen as a useful tool for credit scoring and estimation of the default probability in credit risk. A data-driven bandwidth selection procedure is proposed. It allows to choose the smoothing parameter involved in our approach. The finite sample performance of the estimators has been studied by simulations, where the new method has been compared with the method by Bouaziz and Lopez (2010) [1]. To the best of our knowledge this is the only existing competitor in this context. The simulation study shows the good behaviour of the proposed method.
An Elementary Proof of the Johnson-lindenstrauss Lemma

The Johnson-Lindenstrauss lemma shows that a set of n points in high dimensional Euclidean space can be mapped down into an O(log n== 2) dimensional Euclidean space such that the distance between any two points changes by only a factor of (1). In this note, we prove this lemma using elementary probabilistic techniques.
A novel four-step search algorithm for fast block motion estimation

vector distribution, a new four-step search (4SS) algorithm with center-biased checking point pattern for fast block motion estimation is proposed in this paper. Halfway-stop technique is employed in the new algorithm with searching steps of 2 to 4 and the total number of checking points is varied from 17 to 27. Simulation results show that the proposed 4SS performs better than the well-known three-step search and has similar performance to the new three-step search (N3SS) in terms of motion compensation errors. In addition, the 4SS also reduces the worst-case computational requirement from 33 to 27 search points and the average computational requirement from 21 to 19 search points as compared with N3SS. _______________________________________ This paper was published in IEEE Trans. Circuits Syst. Video Technol., vol. 6, No. 3, pp. 313-317, Jun. 1996. The authors are with the CityU Image Processing Lab, Department of Electronic Engineering, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong. Email: elmpo@cityu.edu.hk
Investigation of circularly polarized loop antennas with a parasitic element for bandwidth enhancement

It is demonstrated that the bandwidth of circular polarization (CP) can be significantly increased when one more parasitic loop is added inside the original loop. A single-loop antenna has only one minimum axial ratio (AR) point while the two-loop antenna can create two minimum AR points. An appropriate combination of the two minimum AR points results in a significant enhancement for the CP bandwidth. A comprehensive study of the new type of broad-band circularly polarized antennas is presented. Several loop configurations, including a circular loop, a rhombic loop, and a dual rhombic loop with a series feed and a parallel feed, are investigated. The AR (/spl les/2 dB) bandwidth of the circular-loop antenna with a parasitic circular loop is found to be 20%, more than three times the AR bandwidth of a single loop. For the rhombic-loop antenna with a parasitic rhombic loop, an AR bandwidth (AR/spl les/2dB) of more than 40% can be achieved by changing the rhombus vertex angle. The AR (/spl les/2 dB) bandwidths of the series-fed and parallel-fed dual rhombic-loop antennas with a parasitic element are 30% and 50%, respectively. A broad-band balun is incorporated into the series-fed dual rhombic-loop antenna for impedance matching. The broad-band CP performance of the loop antennas is verified by experimental results.
Protocol for the ADDITION-Plus study: a randomised controlled trial of an individually-tailored behaviour change intervention among people with recently diagnosed type 2 diabetes under intensive UK general practice care

BACKGROUND
The increasing prevalence of type 2 diabetes poses both clinical and public health challenges. Cost-effective approaches to prevent progression of the disease in primary care are needed. Evidence suggests that intensive multifactorial interventions including medication and behaviour change can significantly reduce cardiovascular morbidity and mortality among patients with established type 2 diabetes, and that patient education in self-management can improve short-term outcomes. However, existing studies cannot isolate the effects of behavioural interventions promoting self-care from other aspects of intensive primary care management. The ADDITION-Plus trial was designed to address these issues among recently diagnosed patients in primary care over one year.


METHODS/DESIGN
ADDITION-Plus is an explanatory randomised controlled trial of a facilitator-led, theory-based behaviour change intervention tailored to individuals with recently diagnosed type 2 diabetes. 34 practices in the East Anglia region participated. 478 patients with diabetes were individually randomised to receive (i) intensive treatment alone (n = 239), or (ii) intensive treatment plus the facilitator-led individual behaviour change intervention (n = 239). Facilitators taught patients key skills to facilitate change and maintenance of key behaviours (physical activity, dietary change, medication adherence and smoking), including goal setting, action planning, self-monitoring and building habits. The intervention was delivered over one year at the participant's surgery and included a one-hour introductory meeting followed by six 30-minute meetings and four brief telephone calls. Primary endpoints are physical activity energy expenditure (assessed by individually calibrated heart rate monitoring and movement sensing), change in objectively measured dietary intake (plasma vitamin C), medication adherence (plasma drug levels), and smoking status (plasma cotinine levels) at one year. We will undertake an intention-to-treat analysis of the effect of the intervention on these measures, an assessment of cost-effectiveness, and analyse predictors of behaviour change in the cohort.


DISCUSSION
The ADDITION-Plus trial will establish the medium-term effectiveness and cost-effectiveness of adding an externally facilitated intervention tailored to support change in multiple behaviours among intensively-treated individuals with recently diagnosed type 2 diabetes in primary care. Results will inform policy recommendations concerning the management of patients early in the course of diabetes. Findings will also improve understanding of the factors influencing change in multiple behaviours, and their association with health outcomes.
Query by Image and Video Content: The QBIC System

Semantic versus nonsemantic information icture yourself as a fashion designer needing images of fabrics with a particular mixture of colors, a museum cataloger looking P for artifacts of a particular shape and textured pattern, or a movie producer needing a video clip of a red car-like object moving from right to left with the camera zooming. How do you find these images? Even though today’s technology enables us to acquire, manipulate, transmit, and store vast on-line image and video collections, the search methodologies used to find pictorial information are still limited due to difficult research problems (see “Semantic versus nonsemantic” sidebar). Typically, these methodologies depend on file IDS, keywords, or text associated with the images. And, although powerful, they
Life's last domain.

In what many scientists are calling a tour de force, a team of researchers report in this issue of Science (page 1058) that they9ve sequenced the entire genome of the archaeon microbe Methanococcus jannaschii. With it researchers have their first chance to compare the complete genomes of organisms from what seem to be the three major branches of life: the archaea, bacteria, and eukarya (which includes multicellular organisms such as plants and animals). A startling 44% of the archaeon9s 1700-odd genes are entirely new to science. Says one researcher: “That9s about half of the organism! It shows just how little we know about life.”
Calogero model with Yukawa-like interaction

Abstract We study an extension of one-dimensional Calogero model involving strongly coupled and electrically charged particles. Besides Calogero term g 2 x 2 , there is an extra factor described by a Yukawa-like coupling modeling short distance interactions. Mimicking Calogero analysis and using developments in formal series of the wave function Ψ ( x ) factorized as x ɛ Φ ( x ) with ɛ ( ɛ − 1 ) = g , we develop a technique to approach the spectrum of the generalized system and show that information on full spectrum is captured by Φ ( x ) and Φ ″ ( x ) at the singular point x = 0 of the potential. Convergence of ∫ d x | Ψ ( x ) | 2 requires ɛ > − 1 2 and is shown to be sensitive to the zero mode of Φ ( x ) at x = 0 .
Elevated serum neutrophil to lymphocyte and platelet to lymphocyte ratios could be useful in lung cancer diagnosis.

BACKGROUND
Lung cancer (LC) is still the primary cause of cancer deaths worldwide, and late diagnosis is a major obstacle to improving lung cancer outcomes. Recently, elevated preoperative or pretreatment neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and mean platelet volume (MPV) detected in peripheral blood were identified as independent prognostic factors associated with poor survival with various cancers, including colon cancer, esophageal cancer, gastric cancer and breast cancer.


OBJECTIVE
The aim of this study was to examine whether MPV, NLR and PLR could be useful inflammatory markers to differentiate lung cancer patients from healthy controls. An investigation was also made of the relationship between these markers and other prognostic factors and histopathological subgroups.


MATERIALS AND METHODS
Retrospectively eighty-one lung cancer patients and 81 age-sexes matched healthy subjects included into the study. Patients with hypertension, hematological and renal disease, heart failure, chronic infection, hepatic disorder and other cancer were excluded from the study. The preoperative or pretreatment blood count data was obtained from the recorded computerized database.


RESULTS
NLR and PLR values were significantly higher in the LC patients compared to the healthy subjects.( NLR: 4.42 vs 2.45 p=0.001, PLR: 245.1 vs 148.2 p=0.002) MPV values were similar in both groups (7.7 vs 7.8). No statistically significant relationship was determined between these markers (MPV, NLR and PLR) and histopathological subgroups and TNM stages.


CONCLUSIONS
NLR and PLR can be useful biomarkers in LC patients before treatment. Larger prospective studies are required to confirm these findings.
Validation of a method to replace frozen section during parathyroid exploration by using the rapid parathyroid hormone assay on parathyroid aspirates.

HYPOTHESIS
The parathyroid hormone (PTH) content of tissue aspirates is an accurate indicator of parathyroid tissue and can replace frozen section during parathyroid surgery.


DESIGN AND SETTINGS
Prospective data collection in a tertiary care hospital with a single surgeon.


PATIENTS
One hundred sixty-seven consecutive patients completing limited parathyroid explorations.


INTERVENTIONS
Parathyroid adenomas removed during limited parathyroid exploration were aspirated through a 22-gauge needle into 0.5 mL isotonic sodium chloride solution and the solution held on ice in a purple-top tube. Aspirates of in situ thyroid tissue were also taken for comparison. Samples were then assessed to monitor the physiologic impact of the surgery.


MAIN OUTCOME MEASUREMENTS
The PTH content of tissue aspirates was compared with histologic identification of removed putative parathyroid tissue.


RESULTS
Elevated tissue PTH content was associated with the identification of origin as parathyroid in every case. Tissue aspirates from pathologically proven parathyroid tissue had a mean PTH level of at least 1691 pg/mL, with 160 having values exceeding the upper limit of the assay. This measure was significantly higher than values obtained from thyroid aspirates, which had a mean PTH level of 88 pg/mL (P<.01), reflective of blood levels at the time of aspiration. Using the 99% confidence interval of histologically confirmed parathyroid glands as the lower limit of a positive test result at 1610 pg/mL, tissue aspirate PTH assay has a sensitivity of 97% and a specificity of 100%.


CONCLUSIONS
Positive identification of removed tissue as parathyroid is necessary adjunct to limited parathyroid exploration, where decreases in false positive blood PTH levels can be a result of operative manipulation of the neck. Analysis of tissue PTH content during the same assay that is being used for assessing blood PTH concentration is an efficient and accurate method for identifying the tissue with certainty. This measure also prevents the occasional ambiguity in frozen sections of parathyroid tissue that apparently contain thyroidlike colloid material.
Longitudinal Alveolar Bone Loss in Postmenopausal Osteoporotic/Osteopenic Women

The purpose of this 2-year longitudinal clinical study was to investigate alveolar (oral) bone height and density changes in osteoporotic/osteopenic women compared with women with normal lumbar spine bone mineral density (BMD). Thirty-eight postmenopausal women completed this study; 21 women had normal BMD of the lumbar spine, while 17 women had osteoporosis or osteopenia of the lumbar spine at baseline. All subjects had a history of periodontitis and participated in 3- to 4-month periodontal maintenance programs. No subjects were current smokers. All patients were within 5 years of menopause at the start of the study. Four vertical bitewing radiographs of posterior sextants were taken at baseline and 2-year visits. Radiographs were examined using computer-assisted densitometric image analysis (CADIA) for changes in bone density at the crestal and subcrestal regions of interproximal bone. Changes in alveolar bone height were also measured. Radiographic data were analyzed by the t-test for two independent samples. Osteoporotic/osteopenic women exhibited a higher frequency of alveolar bone height loss (p<0.05) and crestal (p<0.025) and subcrestal (p<0.03) density loss relative to women with normal BMD. Estrogen deficiency was associated with increased frequency of alveolar bone crestal density loss in the osteoporotic/osteopenic women and in the overall study population (p<0.05). These data suggest that osteoporosis/osteopenia and estrogen deficiency are risk factors for alveolar bone density loss in postmenopausal women with a history of periodontitis.
Uproar and Disorder? The Impact of Bible Christianity on the Communities of Nineteenth Century North Devon

Abstract A considerable part of the rural depopulation of North Devon in the first half of the 19th century was attributable to emigration. Examination of individual emigrants shows that the majority were not stereotypical, impoverished agricultural labourers but more substantial tradesmen, many of whom adhered to the Bible Christian faith. Although followers were described as being 'almost without exception of the lowest classes of society' (Wickes 1987: 38) and were accused of behaviour that was 'uproarious and disorderly' (North Devon Journal(NDJ) 9 December 1858); both are statements that warrant scrutiny. This article considers the impact of Bible Christianity on the inhabitants of the hamlet of Bucks Mills and the parish of Buckland Brewer. Using case studies of individuals from these areas, it investigates the characteristics of early nineteenth century Bible Christian emigrants and examines the role of their faith as a motivating factor for migration.