LLukas22/scidocs huggingface dataset:
Cure of Helicobacter pylori infection in patients with reflux oesophagitis treated with long term omeprazole reverses gastritis without exacerbation of reflux disease: results of a randomised controlled trial.

BACKGROUND
Helicobacter pylori gastritis may progress to glandular atrophy and intestinal metaplasia, conditions that predispose to gastric cancer. Profound suppression of gastric acid is associated with increased severity of H pylori gastritis. This prospective randomised study aimed to investigate whether H pylori eradication can influence gastritis and its sequelae during long term omeprazole therapy for gastro-oesophageal reflux disease (GORD).


METHODS
A total of 231 H pylori positive GORD patients who had been treated for > or =12 months with omeprazole maintenance therapy (OM) were randomised to either continuation of OM (OM only; n = 120) or OM plus a one week course of omeprazole, amoxycillin, and clarithromycin (OM triple; n = 111). Endoscopy with standardised biopsy sampling as well as symptom evaluation were performed at baseline and after one and two years. Gastritis was assessed according to the Sydney classification system for activity, inflammation, atrophy, intestinal metaplasia, and H pylori density.


RESULTS
Corpus gastritis activity at entry was moderate or severe in 50% and 55% of the OM only and OM triple groups, respectively. In the OM triple group, H pylori was eradicated in 90 (88%) patients, and activity and inflammation decreased substantially in both the antrum and corpus (p<0.001, baseline v two years). Atrophic gastritis also improved in the corpus (p<0.001) but not in the antrum. In the 83 OM only patients with continuing infection, there was no change in antral and corpus gastritis activity or atrophy, but inflammation increased (p<0.01). H pylori eradication did not alter the dose of omeprazole required, or reflux symptoms.


CONCLUSIONS
Most H pylori positive GORD patients have a corpus predominant pangastritis during omeprazole maintenance therapy. Eradication of H pylori eliminates gastric mucosal inflammation and induces regression of corpus glandular atrophy. H pylori eradication did not worsen reflux disease or lead to a need for increased omeprazole maintenance dose. We therefore recommend eradication of H pylori in GORD patients receiving long term acid suppression.
Geometric deep learning

Machine Learning on graphs and manifolds are important ubiquitous tasks with applications ranging from network analysis to 3D shape analysis. Traditionally, machine learning approaches relied on user-defined heuristics to extract features encoding structural information about a graph or mesh. Recently, there has been an increasing interest in geometric deep learning [6] that automatically learns signals defined on graphs and manifolds. We are then motivated to apply such methods to address the multifaceted challenges arising in computational biology and computer graphics for decades, i.e. protein function prediction and 3D facial expression recognition. Here we propose a deep graph neural network to successfully address the semi-supervised multi-label classification problem (i.e. protein function prediction). With regard to 3D facial expression recognition, we propose a deep residual B-Spline graph convolution network, which allows for end-to-end training and inference without using hand-crafted feature descriptors. Our method outperforms the current baseline results on 4DFAB [10] dataset.
Facundo and the construction of Argentine culture

Acknowledgments Introduction One. The Wars Of Persuasion: Conflict, Interpretation, and Power in the Early Years of Facundo's Reception Two. The Risks Of Fiction: Facundo and the Parameters of Historical Writing Three. The Wiles Of Disputation: Alberdi Reads Facundo Four. Facundo's Travels To The Metropolitan Centers Five. The Nation Consolidated: The 1880's and the Canonization of Facundo Six. A Classic Corrected: Rewriting the National Myths Notes Bibliography Index
Web science: an interdisciplinary approach to understanding the web

The Web must be studied as an entity in its own right to ensure it keeps flourishing and prevent unanticipated social effects.
[Implementation of diabetic retinopathy screening using digital retinography in primary care].

OBJECTIVE
To improve early detection and monitoring of diabetic retinopathy (DR) in two primary care centers (PCC) using a non-mydriatic retinal camera (NMRC).


DESIGN
Prospective longitudinal descriptive study.


LOCATION
Area 11 Primary Care, Madrid.


PARTICIPANTS
Adult patients with diabetes (DM) without funduscopic examination in the last two years (FO).


INTERVENTIONS
Implementation process of screening for DR by NMRC in PCC. Digital photography of the retina made by nursing staff. Interpretation of retinal images by an ophthalmologist.


MEASUREMENTS
Number of DM with FO. Number of patients with DR. Metabolic control in the last two years (HbA1c).


STUDY PERIOD
September 2009-September 2011.


RESULTS
DM increased from 2850 to 3357. The proportion of patients with FO increased from 6.7% (95% CI: 5.7-7.6%) to 32.4% (95% CI: 30.8-34.0%) (P<.001). The prevalence of DR increased from 3.85% (95% CI: 3.14-4.58%) to 4.3% (95% CI: 3.59-4.99%). The percentage of patients with FO and DR decreased from 60% (95% CI: 52.77-67.23%) to 14% (95% CI: 11.87-16.09%) (P<.001). The proportion of DM with HbA1c increased from 21.9% (95% CI: 20.36-23.43%) to 52.4% (95% CI: 50.69-54.10%) (P<.001). The mean HbA1c in patients with DR and without DR was 7.8 (95% CI: 7.50-8.06) and 7.1 (IC95% CI: 7.08-7.22) (P<.001), respectively.


CONCLUSIONS
NMRC in PCC is accompanied by an increase in the number of diabetics with FO examination. The implementing of DR screening is possible if an NMRC is available, along with available resources, the motivation of the professionals involved and management commitment. A longer follow-up is required to determine its impact on referral rates to ophthalmology service, and to only refer those with dubious images.
An Experimental Evaluation of a Monte-Carlo Algorithm for Singular Value Decomposition

We demonstrate that an algorithm proposed by Drineas et. al. in [7] to approximate the singular vectors/values of a matrix A, is not only of theoretical interest but also a fast, viable alternative to traditional algorithms. The algorithm samples a small number of rows (or columns) of the matrix, scales them appropriately to form a small matrix S and computes the singular value decomposition (SVD) of S, which is a good approximation to the SVD of the original matrix. We experimentally evaluate the accuracy and speed of this randomized algorithm using image matrices and three different sampling schemes. Our results show that our approximations of the singular vectors of A span almost the same space as the corresponding exact singular vectors of A.
Implementing Gabor Filter for fingerprint recognition using Verilog HDL

This paper present the implementations of Gabor filter for fingerprint recognition using Verilog HDL. This work demonstrates the application of Gabor Filter technique to enhance the fingerprint image. The incoming signal in form of image pixel will be filter out or convolute by the Gabor filter to define the ridge and valley regions of fingerprint. This is done with the application of a real time convolve based on Field Programmable Gate Array (FPGA) to perform the convolution operation. The main characteristic of the proposed approach are the usage of memory to store the incoming image pixel and the coefficient of the Gabor filter before the convolution matrix take place. The result was the signal convoluted with the Gabor coefficient.
Waveform Driven Plasticity in BiFeO3 Memristive Devices: Model and Implementation

Memristive devices have recently been proposed as efficient implementations of plastic synapses in neuromorphic systems. The plasticity in these memristive devices, i.e. their resistance change, is defined by the applied waveforms. This behavior resembles biological synapses, whose plasticity is also triggered by mechanisms that are determined by local waveforms. However, learning in memristive devices has so far been approached mostly on a pragmatic technological level. The focus seems to be on finding any waveform that achieves spike-timing-dependent plasticity (STDP), without regard to the biological veracity of said waveforms or to further important forms of plasticity. Bridging this gap, we make use of a plasticity model driven by neuron waveforms that explains a large number of experimental observations and adapt it to the characteristics of the recently introduced BiFeO3 memristive material. Based on this approach, we show STDP for the first time for this material, with learning window replication superior to previous memristor-based STDP implementations. We also demonstrate in measurements that it is possible to overlay short and long term plasticity at a memristive device in the form of the well-known triplet plasticity. To the best of our knowledge, this is the first implementations of triplet plasticity on any physical memristive device.
Detection and diagnosis of periodontal conditions amenable to prevention

Gingivitis and chronic periodontitis are highly prevalent chronic inflammatory diseases. Gingivitis affects the majority of people, and advanced periodontitis is estimated to affect 5-15% of adults. The detection and diagnosis of these common diseases is a fundamentally important component of oral health care. All patients should undergo periodontal assessment as part of routine oral examination. Periodontal screening using methods such as the Basic Periodontal Examination/Community Periodontal Index or Periodontal Screening Record should be performed for all new patients, and also on a regular basis as part of ongoing oral health care. If periodontitis is identified, full periodontal assessment is required, involving recording of full mouth probing and bleeding data, together with assessment of other relevant parameters such as plaque levels, furcation involvement, recession and tooth mobility. Radiographic assessment of alveolar bone levels is driven by the clinical situation, and is required to assess bone destruction in patients with periodontitis. Risk assessment (such as assessing diabetes status and smoking) and risk management (such as promoting smoking cessation) should form a central component of periodontal therapy. This article provides guidance to the oral health care team regarding methods and frequencies of appropriate clinical and radiographic examinations to assess periodontal status, to enable appropriate detection and diagnosis of periodontal conditions.
V2X-Based Traffic Congestion Recognition and Avoidance

Vehicular traffic congestion is a global phenomenon that has increased in importance in the last decades and has caused economically and ecologically negative effects. Thus, finding a way to improve traffic efficiency is a high-frequented problem to be solved by scientists and politicians worldwide. One new promising approach is the usage of decentralized wireless vehicle to vehicle communication based on the Vehicle-2-X (V2X) technology. The idea is that vehicles share information about the current local traffic situation and use this information to optimize their routes. In this paper, we introduce a new algorithm that can be used by navigation systems to calculate routes circumnavigating congested roads. For this purpose, each vehicle transmits its average speed of a road segment to vehicles in the neighbourhood. As a result, vehicles receiving this information can recalculate their routes based on the knowledge about the current possible speeds in the road segments of their neighbourhood. To evaluate the improvements that can be achieved by our algorithm, simulations have been done. Our results show that navigation systems using the V2X technology for a more intelligent route calculation can improve the traffic efficiency of future transport systems.
Age-related fatigability of the ankle dorsiflexor muscles during concentric and eccentric contractions

This study compares the fatigability of the ankle dorsiflexors during five sets of 30 maximal concentric and eccentric contractions in young and elderly adults. The torque produced by the ankle dorsiflexors and the average surface electromyogram (aEMG) of the tibialis anterior were continuously recorded. The contribution of central and peripheral mechanisms to muscle fatigue was tested before, after each set of contractions, and during a 30 min recovery period by the superimposed electrical stimulation method. The compound muscle action potential (M-wave), the mechanical response to single (twitch) and paired (doublet) stimulation, and the postactivation potentiation were also recorded. Compared with young subjects, elderly adults exhibited a greater loss of torque for concentric (50.2 vs. 40.9%; P<0.05) and eccentric (42.1 vs. 27.1%; P < 0.01) contractions. Although young subjects showed a lesser decrease in torque during the eccentric compared with concentric contractions, elderly adults experienced similar fatigability for the two types of contractions despite a comparable depression in the EMG activity of both groups and contraction types (10–20%). As tested by the interpolated-twitch method and aEMG/M-wave ratio, voluntary activation was not altered during either type of contraction or for either age group. During the two fatigue tasks, only elderly adults experienced a decrease in M-wave area (26.4–35.4%; P < 0.05). All together, our results suggest that the fatigue exhibited by both young and elderly adults during maximal concentric and eccentric contractions mainly involved peripheral alterations and that elderly adults may also have experienced a decline in neuromuscular propagation.
Analysis of operating system diversity for intrusion tolerance

One of the key benefits of using intrusion-tolerant systems is the possibility of ensuring correct behavior in the presence of attacks and intrusions. These security gains are directly dependent on the components exhibiting failure diversity. To what extent failure diversity is observed in practical deployment depends on how diverse are the components that constitute the system. In this paper, we present a study with operating system’s (OS’s) vulnerability data from the NIST National Vulnerability Database (NVD). We have analyzed the vulnerabilities of 11 different OSs over a period of 18 years, to check how many of these vulnerabilities occur in more than one OS. We found this number to be low for several combinations of OSs. Hence, although there are a few caveats on the use of NVD data to support definitive conclusions, our analysis shows that by selecting appropriate OSs, one can preclude (or reduce substantially) common vulnerabilities from occurring in the replicas of the intrusion-tolerant system. Copyright © 2013 John Wiley & Sons, Ltd.
Allergic proctocolitis refractory to maternal hypoallergenic diet in exclusively breast-fed infants: a clinical observation

BACKGROUND
Allergic proctocolitis (APC) in exclusively breast-fed infants is caused by food proteins, deriving from maternal diet, transferred through lactation. In most cases a maternal cow milk-free diet leads to a prompt resolution of rectal bleeding, while in some patients a multiple food allergy can occur. The aim of this study was to assess whether the atopy patch test (APT) could be helpful to identify this subgroup of patients requiring to discontinue breast-feeding due to polisensitization. Additionally, we assessed the efficacy of an amino acid-based formula (AAF) when multiple food allergy is suspected. amino acid-based formula


METHODS
We have prospectively enrolled 14 exclusively breast-fed infants with APC refractory to maternal allergen avoidance. The diagnosis was confirmed by endoscopy with biopsies. Skin prick tests and serum specific IgE for common foods, together with APTs for common foods plus breast milk, were performed. After a 1 month therapy of an AAF all patients underwent a follow-up rectosigmoidoscopy.


RESULTS
Prick tests and serum specific IgE were negative. APTs were positive in 100% infants, with a multiple positivity in 50%. Sensitization was found for breast milk in 100%, cow's milk (50%), soy (28%), egg (21%), rice (14%), wheat (7%). Follow-up rectosigmoidoscopy confirmed the remission of APC in all infants.


CONCLUSIONS
These data suggest that APT might become a useful tool to identify subgroups of infants with multiple gastrointestinal food allergy involving a delayed immunogenic mechanism, with the aim to avoid unnecessary maternal dietary restrictions before discontinuing breast-feeding.
Freedom for bibliographic references: OpenCitations arise

Scholarly citations from one publication to another, expressed as reference lists within academic articles, are core elements of scholarly communication. Unfortunately, they usually can be accessed en masse only by paying significant subscription fees to commercial organizations, while those few services that do made them available for free impose strict limitations on their reuse. In this paper we provide an overview of the OpenCitations Project (http://opencitations.net) undertaken to remedy this situation, and of its main product, the OpenCitations Corpus, which is an open repository of accurate bibliographic citation data harvested from the scholarly literature, made available in RDF under a Creative Commons public domain dedication. RASH version: https://w3id.org/oc/paper/occ-lisc2016.html
The lateral spread of light adaptation in cat horizontal cell responses

To investigate the sites of light adaptation processes in the mammalian distal retina, we studied the lateral spread of adaptation signals in cone-driven cat horizontal (H-) cell responses. The size of the adaptation pool is compared to the receptive field for H-cell responses. H-cell activity was recorded intracellularly in the optically intact, in vivo eye. It is demonstrated that light adaptation as measured in H-cells is not a strictly local process. Background light falling outside a central test region effectively modulates the responses to a small test light, flashed on the receptive field center. The integration area for adaptation signals was quantitatively compared to the H-cell receptive field size by measuring the desensitizing effect of background light on the responses to a small centered test spot, as a function of background spot size. The area-adaptation function is comparable to the area-response function but has a slightly smaller length constant. Light adaptation in H-cell responses, therefore, reveals spread of adaptation over a large distance and is probably mediated through lateral interactions in the H-cell network rather than in the cones.
The LuxR family members GdmRI and GdmRII are positive regulators of geldanamycin biosynthesis in Streptomyces hygroscopicus 17997

The recent sequencing of the DNA region of the geldanamycin post-polyketide synthase (PKS) modification gene clusters revealed the presence of two regulatory genes: gdmRI (2,907 bp) and gdmRII (2,766 bp). The deduced products of gdmRI and gdmRII (968 and 921 amino acid residues, respectively) were identified as homologues of the LuxR transcriptional regulatory proteins. Inactivation by gene replacement of gdmRI or gdmRII in the Streptomyces hygroscopicus 17997 genome resulted in a complete loss of geldanamycin production. Complementation by a plasmid carrying gdmRI or gdmRII restored geldanamycin production, suggesting that the products of these two regulatory genes are positive regulators that are required for geldanamycin biosynthesis. The gdmRI transcript was detected in the ΔgdmRII mutant, and the gdmRII was detected in the ΔgdmRI mutant, indicating that the two genes are transcribed independently and do not regulate each other. Time course of gene expression analysis by RT-PCR of the geldanamycin biosynthetic genes showed that the transcription of gdmRI and gdmRII correlates with that of genes involved in polyketide biosynthesis, but not with the post-PKS modification gene gdmN, whose transcription is initiated earlier. gdmRI or gdmRII gene disruptants did not transcribe the polyketide biosynthetic related genes pks, gdmF, and gdnA-O-P, but did trancribe gdmN. These results demonstrated that gdmRI and gdmRII are pathway-specific positive regulators that control the polyketide biosynthetic genes in geldanamycin biosynthsis, but not the post-PKS modification gene, gdmN.
Oxaliplatin-containing Preoperative Therapy in Locally Advanced Rectal Cancer: Local Response, Toxicity and Long-term Outcome.

AIMS
This non-randomised study was undertaken to examine oxaliplatin as possibly an intensifying component of sequential neoadjuvant therapy in locally advanced rectal cancer for improved local and metastatic outcome.


MATERIALS AND METHODS
Ninety-seven patients (57 T2-3 cases, 40 T4 cases) received two cycles of the Nordic FLOX regimen (oxaliplatin 85 mg/m(2) day 1 and bolus 5-fluorouracil 500 mg/m(2) and folinic acid 100 mg days 1 and 2) before long-course chemoradiotherapy with concomitant oxaliplatin and capecitabine, followed by pelvic surgery. Treatment toxicity, local tumour response and long-term outcome were recorded.


RESULTS
Good histologic tumour regression was obtained in 72% of patients. Implementing protocol-specific dose adjustments, tolerance was acceptable and 95% of patients received the total prescribed radiation dose. Estimated 5 year progression-free and overall survival were 61% and 83%, respectively. T4 stage was associated with an inferior local response rate, which again was highly associated with impaired long-term outcome.


CONCLUSIONS
In this cohort of rectal cancer patients dominated by T4 and advanced T3 cases given sequential oxaliplatin-containing preoperative therapy with acceptable toxicity, high tumour response rates and overall survival were obtained, consistent with both local and systemic effects. However, tumour response and long-term outcome remained inferior for a significant number of T4 cases, suggesting that the T4 entity is biologically heterogeneous with subgroups of patients eligible for further individualisation of therapy.
Low energy KTP laser in oral soft tissues surgery: A 52 patients clinical study

OBJECTIVES
Since 1962 laser appliances have been used for soft tissues surgery of oral cavity with significant advantages compared to the traditional instruments: excellent bleeding control, possibility to avoid the use of suture, good patient compliance thanks to a decrease of intra- and post-operative discomfort and biostimulating effect. Unfortunately, the wavelengths so far used have been seen to cause, in association with an excellent ablation capacity, heat damage of the tissues that can decrease healing process and cause a greater discomfort to patients. To evaluate the laser-assisted KTP laser surgery at low power in terms of characteristics of intervention and patients compliance.


STUDY DESIGN
In this study, we describe the application of a new and recently introduced in dentistry wavelength, the KTP laser (532 nm), used with low power parameter (1 Watt - CW), evaluating the time of interventions and, by a Numerical Rating Scale, the intra and postoperative pain.


RESULTS
KTP laser used at low power permits to obtain good pain control during operations that were carried out with only a topic anaesthetic (EMLA, Astratech), as shown in VAS tests. Good healing with limited or absent burning areas in treated portion of tissue.


CONCLUSIONS
These preliminary study allows us to affirm that KTP laser with low parameters permits to perform oral surgery with good pain control and good wound healing. A greater number of clinical cases are however necessary to confirm the result obtained.