LLukas22/scidocs huggingface dataset:
Language and motor mapping during resection of brain arteriovenous malformations: indications, feasibility, and utility.

BACKGROUND
Microsurgical resection of arteriovenous malformations (AVMs) located in the language and motor cortex is associated with the risk of neurological deterioration, yet electrocortical stimulation mapping has not been widely used.


OBJECTIVE
To demonstrate the usefulness of intraoperative mapping with language/motor AVMs.


METHODS
During an 11-year period, mapping was used in 12 of 431 patients (2.8%) undergoing AVM resection (5 patients with language and 7 patients with motor AVMs). Language mapping was performed under awake anesthesia and motor mapping under general anesthesia.


RESULTS
Identification of a functional cortex enabled its preservation in 11 patients (92%), guided dissection through overlying sulci down to the nidus in 3 patients (25%), and influenced the extent of resection in 4 patients (33%). Eight patients (67%) had complete resections. Four patients (33%) had incomplete resections, with circumferentially dissected and subtotally disconnected AVMs left in situ, attached to areas of eloquence and with preserved venous drainage. All were subsequently treated with radiosurgery. At follow-up, 6 patients recovered completely, 3 patients were neurologically improved, and 3 patients had new neurological deficits.


CONCLUSION
Indications for intraoperative mapping include preoperative functional imaging that identifies the language/motor cortex adjacent to the AVM; larger AVMs with higher Spetzler-Martin grades; and patients presenting with unruptured AVMs without deficits. Mapping identified the functional cortex, promoted careful tissue handling, and preserved function. Mapping may guide dissection to AVMs beneath the cortical surface, and it may impact the decision to resect the AVM completely. More conservative, subtotal circumdissections followed by radiosurgery may be an alternative to observation or radiosurgery alone in patients with larger language/motor cortex AVMs.
New Hardy Spaces of Musielak–Orlicz Type and Boundedness of Sublinear Operators

We introduce a new class of Hardy spaces H(R), called Hardy spaces of Musielak-Orlicz type, which generalize the Hardy-Orlicz spaces of Janson and the weighted Hardy spaces of Garćıa-Cuerva, Strömberg, and Torchinsky. Here, φ : R × [0,∞) → [0,∞) is a function such that φ(x, ·) is an Orlicz function and φ(·, t) is a MuckenhouptA∞ weight. A function f belongs to H(R) if and only if its maximal function f∗ is so that x 7→ φ(x, |f∗(x)|) is integrable. Such a space arises naturally for instance in the description of the product of functions in H(R) and BMO(R) respectively (see [6]). We characterize these spaces via the grand maximal function and establish their atomic decomposition. We characterize also their dual spaces. The class of pointwise multipliers for BMO(R) characterized by Nakai and Yabuta can be seen as the dual of L(R)+H (R) where H (R) is the Hardy space of Musielak-Orlicz type related to the Musielak-Orlicz function θ(x, t) = t log(e+ |x|) + log(e+ t) . Furthermore, under additional assumption on φ(·, ·) we prove that if T is a sublinear operator and maps all atoms into uniformly bounded elements of a quasi-Banach space B, then T uniquely extends to a bounded sublinear operator from H(R) to B. These results are new even for the classical Hardy-Orlicz spaces on R.
Phase I study of capecitabine in combination with cisplatin and irinotecan in patients with advanced solid malignancies

Purpose: This phase I trial assessed the safety and the maximum tolerated dose of capecitabine given for 10 days prior to a combination of cisplatin and irinotecan in patients with advanced solid malignancies. It also evaluated the changes in cisplatin DNA adducts induced by capecitabine. Patients and Methods: Patients with refractory solid tumors who had not failed 5-fluorouracil (5-FU) analogs or topoisomerase I inhibitors were eligible. All cohorts of patients first received a 28-day cycle of cisplatin and irinotecan. Both drugs were given at a dose of 50 mg/m2 intravenously on day 1, followed by irinotecan on days 8 and 15 at the same dose. The first cycle served as an internal control. Starting from the second cycle, patients received increasing doses per cohort of capecitabine from day 1 to 10 of each cycle, followed by cisplatin on day 11 and irinotecan on days 11, 18 and 25, both at same doses as the first cycle. Cycles were repeated every 38 days. The starting dose of capecitabine was 500 mg/m2/day which was escalated by 250 mg/m2/day in the subsequent cohort of patients to reach the maximum tolerated dose (MTD). Later, additional patients were treated at the MTD of capecitabine to further evaluate the safety, pharmacodynamics, and tumor response. Patients blood was tested for cisplatin-DNA adducts to determine the impact of capecitabine on cisplatin-based therapy. Results: Fifteen patients received at least 2 cycles of treatment. At 1,250 mg/m2, two DLT of prolonged neutropenia of grade ≥3 were observed. The MTD for capecitabine was thus determined to be 1000 mg/m2/day. Fatigue and diarrhea of grade 1 or 2 were the most frequent toxicities at this dose level. No significant hematologic toxicity was observed at the MTD. Two complete and three partial remissions were observed. Four of the responders had received a platinum agent and/or 5-FU in the past. Conclusions: A sequential treatment with capecitabine followed by cisplatin and irinotecan is well tolerated and demonstrates clinical activity in patients with advanced solid malignancies. The influence of capecitabine, if any, on the efficacy of the cisplatin-irinotecan combination is not related to a variation in cisplatin-DNA adducts.
Effect of a novel NOP receptor agonist (SCH 225288) on guinea pig irritant-evoked, feline mechanically induced and canine infectious tracheobronchitis cough.

BACKGROUND
Previous studies have demonstrated that nociceptin/orphanin FQ (N/OFQ), the endogenous peptide ligand for the G-protein-coupled NOP receptor, inhibits cough in experimental models. SCH 225288 is a nonpeptide, orally active NOP agonist that may provide the foundation for the development of novel treatments for cough.


METHODS
First we characterized the selectivity of SCH 225288 in human receptor binding assays. Afterwards, the antitussive activity of SCH 225288 was studied in three mechanistically distinct cough models. Specifically, we observed the cough-suppressant effect of SCH 225288 in a guinea pig capsaicin irritant-evoked cough model, a feline mechanically induced cough model and finally in a canine Bordetella bronchiseptica disease model.


RESULTS
SCH 225288 selectively binds human NOP receptor (K(i) = 0.38 +/- 0.02 nmol/l) over classical opioid receptors (COR). In a guinea pig capsaicin cough model, SCH 225288 (0.1-1 mg/kg) suppressed cough at 2, 4, and 6 h after oral administration. The antitussive effect of SCH 225288 (3.0 mg/kg, p.o.) was blocked by the NOP antagonist J113397 (12 mg/kg, i.p.) but not by the classical opioid receptor (COR) antagonist, naltrexone (3.0 mg/kg, i.p.). In the anesthetized cat, we evaluated the effects of SCH 225288 given either intravenously or via the intravertebral artery against the increases in cough number and respiratory expiratory and inspiratory muscle (rectus abdominis and parasternal) electromyographic (EMG) activities due to perturbations of the intrathoracic trachea. SCH 225288 (0.03-3.0 mg/kg, i.v.) inhibited both cough number and abdominal EMG amplitudes. Similarly, SCH 225288 (0.001-0.3 mg/kg) administered intra-arterially also diminished cough number and abdominal EMG amplitudes. No significant effect of the drug was noted on parasternal EMG activity. Finally, we studied the antitussive actions of SCH 225288 (1.0 mg/kg) in a canine B. bronchiseptica disease model. In this model, dogs were challenged intranasally with B. bronchiseptica. Comparisons were made between a vehicle group, an SCH 225288 (1.0 mg/kg, p.o., q.d.) and a butorphanol (0.6 mg/kg, p.o., b.i.d.) group on the mean change in cough scores from baseline values and days 6-9 after B. bronchiseptica challenge. SCH 225288 (1.0 mg/kg, p.o., q.d.) displayed a positive antitussive tendency (p = 0.06) to inhibit B. bronchiseptica cough whereas butorphanol (0.6 mg/kg, p.o., b.i.d.) was devoid of antitussive activity.


CONCLUSIONS
Taken together, the present data show that SCH 225288 is a potent and effective antitussive agent in animal models of cough. Furthermore, these findings indicate that NOP agonists represent a promising new therapeutic approach for the treatment of cough without the side effect liabilities associated with opioid antitussives.
Fractionated radioimmunotherapy with (90) Y-clivatuzumab tetraxetan and low-dose gemcitabine is active in advanced pancreatic cancer: A phase 1 trial.

BACKGROUND
It has been demonstrated that the humanized clivatuzumab tetraxetan (hPAM4) antibody targets pancreatic ductal carcinoma selectively. After a trial of radioimmunotherapy that determined the maximum tolerated dose of single-dose yttrium-90-labeled hPAM4 ((90) Y-hPAM4) and produced objective responses in patients with advanced pancreatic ductal carcinoma, the authors studied fractionated radioimmunotherapy combined with low-dose gemcitabine in this disease.


METHODS
Thirty-eight previously untreated patients (33 patients with stage IV disease and 5 patients with stage III disease) received gemcitabine 200 mg/m(2) weekly for 4 weeks with (90) Y-hPAM4 given weekly in Weeks 2, 3, and 4 (cycle 1), and the same cycle was repeated in 13 patients (cycles 2-4). In the first part of the study, 19 patients received escalating weekly (90) Y doses of 6.5 mCi/m(2) , 9.0 mCi/m(2) , 12.0 mCi/m(2) , and 15.0 mCi/m(2) . In the second portion, 19 additional patients received weekly doses of 9.0 mCi/m(2) or 12.0 mCi/m(2) .


RESULTS
Grade 3/4 thrombocytopenia or neutropenia (according to version 3.0 of the National Cancer Institute's Common Terminology Criteria for Adverse Events) developed in 28 of 38 patients after cycle 1 and in all retreated patients; no grade >3 nonhematologic toxicities occurred. Fractionated dosing of cycle 1 allowed almost twice the radiation dose compared with single-dose radioimmunotherapy. The maximum tolerated dose of (90) Y-hPAM4 was 12.0 mCi/m(2) weekly for 3 weeks for cycle 1, with ≤9.0 mCi/m(2) weekly for 3 weeks for subsequent cycles, and that dose will be used in future trials. Six patients (16%) had partial responses according to computed tomography-based Response Evaluation Criteria in Solid Tumors, and 16 patients (42%) had stabilization as their best response (58% disease control). The median overall survival was 7.7 months for all 38 patients, including 11.8 months for those who received repeated cycles (46% [6 of 13 patients] ≥1 year), with improved efficacy at the higher radioimmunotherapy doses.


CONCLUSIONS
Fractionated radioimmunotherapy with (90) Y-hPAM4 and low-dose gemcitabine demonstrated promising therapeutic activity and manageable myelosuppression in patients with advanced pancreatic ductal carcinoma.
Antenatal Risk Factors Associated with the Development of Lenticulostriate Vasculopathy (LSV) in Neonates

OBJECTIVE:To determine the antenatal risk factors associated with neonatal lenticulostriate vasculopathy (LSV).STUDY DESIGN:Women in preterm labor were randomized to magnesium sulfate (MgSO4), other tocolytic, or saline control. The surviving babies underwent head ultrasounds (HUS) (weeks of life 1, 2, and 4) and periodic developmental examinations (months 4, 8, 12, and 18).RESULTS:Of 140 infants, 17.1% (24) had neonatal intraventricular hemorrhage (IVH), and 10.0% (14) had LSV (half of the latter (7 of 14) had both IVH and LSV). In a regression model in which other risk factors were controlled for, the association between antenatal exposures to tocolytic MgSO4 ≥50 g and LSV were significant (adjusted odds ratio (OR), 8.3; 95% confidence interval (CI), 1.5 to 45.0; p=0.01).CONCLUSION:Based on our data and their analyses, we infer that antenatal exposure to high-dosage, tocolytic MgSO4 may be associated with LSV.
Income, health, and well-being around the world: evidence from the Gallup World Poll.

T he great promise of surveys in which people report their own level of life satisfaction is that such surveys might provide a straightforward and easily collected measure of individual or national well-being that aggregates over the various components of well-being, such as economic status, health, family circumstances, and even human and political rights. Layard (2005) argues forcefully such measures do indeed achieve this end, providing measures of individual and aggregate happiness that should be the only gauges used to evaluate policy and progress. Such a position is in sharp contrast to the more widely accepted view, associated with Sen (1999), which is that human well-being depends on a range of functions and capabilities that enable people to lead a good life, each of which needs to be directly and objectively measured and which cannot, in general, be aggregated into a single summary measure. Which of life’s circumstances are important for life satisfaction, and which—if any—have permanent as opposed to merely transitory effects, has been the subject of lively debate. For economists, who usually assume that higher incomes represent a gain to the satisfaction of individuals, the role of income is of particular interest. It is often argued that income is both relatively unimportant and relatively transitory compared with family circumstances, unemployment, or health (for example, Easterlin, 2003). Comparing results from a given country over time, Easterlin (1974, 1995) famously noted that average national happiness does not increase over long spans of time, in spite of large increases in per capita income. These
Non-foster circuits for small broadband antennas

As is well known antenna size implies limitations in bandwidth and gain characteristics. However, if non-Foster / Negative circuits are employed such restrictions can be partially overcome. That is negative matching circuits can provide a way to construct very small efficient antennas. Non-Foster circuits have been considered since 1950's when Negative Impedance Converters (NIC) were proposed [1]. NIC's can be realized via a combination of active devices (transistors) as well as lumped capacitors and inductors. Still, inherent losses, noise issues and bandwidth limitations from available active elements have precluded their use except for narrow bandwidth applications. But, recent advancements in integrated circuits have renewed interest in non-Foster/negative matching.
Multimodal Brain MRI Tumor Segmentation via Convolutional Neural Networks

Introduction • Gliomas are the most commonly occurring type of brain tumors and are potentially very dangerous [2, 1], with about 90% of gliomas belonging to a highly aggressive class of cancerous tumors known as glioblastomas [4]. • Multimodality magnetic resonance imaging is the primary method of screening and diagnosis for gliomas [4]. • Tumor regions currently are segmented manually by radiologists. • Segmentation algorithms based on convolutional neural networks (CNNs) have been shown to be at least as effective as other automated segmentation methods.
Modeling linear logic with implicit functions

Abstract Just as intuitionistic proofs can be modeled by functions, linear logic proofs, being symmetric in the inputs and outputs, can be modeled by relations (for example, cliques in coherence spaces). However generic relations do not establish any functional dependence between the arguments, and therefore it is questionable whether they can be thought as reasonable generalizations of functions. On the other hand, in some situations (typically in differential calculus) one can speak in some precise sense about an implicit functional dependence defined by a relation. It turns out that it is possible to model linear logic with implicit functions rather than general relations, an adequate language for such a semantics being (elementary) differential calculus. This results in a non-degenerate model enjoying quite strong completeness properties.
It's complicated: how romantic partners use facebook

Romantic partners face issues of relational development including managing information privacy, tension between individual and relational needs, and accountability to existing friends. Prior work suggests that affordances of social media might highlight and shape these tensions; to explore this, we asked 20 people to reflect daily for two weeks on feelings and decisions around their own and others' Facebook use related to their relationships. Most generally, we find that tensions arise when romantic partners must manage multiple relationships simultaneously because Facebook audiences are so present and so varied. People also engage in subtle negotiation around and appropriation of Facebook's features to accomplish both personal and relational goals. By capturing both why people make these decisions and how Facebook's affordances support them, we expect our findings to generalize to many other social media tools and to inform theorizing about how these tools affect relational development.
Feature compensation in the cepstral domain employing model combination

In this paper, we present an effective cepstral feature compensation scheme which leverages knowledge of the speech model in order to achieve robust speech recognition. In the proposed scheme, the requirement for a prior noisy speech database in off-line training is eliminated by employing parallel model combination for the noise-corrupted speech model. Gaussian mixture models of clean speech and noise are used for the model combination. The adaptation of the noisy speech model is possible only by updating the noise model. This method has the advantage of reduced computational expenses and improved accuracy for model estimation since it is applied in the cepstral domain. In order to cope with time-varying background noise, a novel interpolation method of multiple models is employed. By sequentially calculating the posterior probability of each environmental model, the compensation procedure can be applied on a frame-by-frame basis. In order to reduce the computational expense due to the multiple-model method, a technique of sharing similar Gaussian components is proposed. Acoustically similar components across an inventory of environmental models are selected by the proposed sub-optimal algorithm which employs the Kullback–Leibler similarity distance. The combined hybrid model, which consists of the selected Gaussian components is used for noisy speech model sharing. The performance is examined using Aurora2 and speech data for an in-vehicle environment. The proposed feature compensation algorithm is compared with standard methods in the field (e.g., CMN, spectral subtraction, RATZ). The experimental results demonstrate that the proposed feature compensation schemes are very effective in realizing robust speech recognition in adverse noisy environments. The proposed model combination-based feature compensation method is superior to existing model-based feature compensation methods. Of particular interest is that the proposed method shows up to an 11.59% relative WER reduction compared to the ETSI AFE front-end method. The multi-model approach is effective at coping with changing noise conditions for input speech, producing comparable performance to the matched model condition. Applying the mixture sharing method brings a significant reduction in computational overhead, while maintaining recognition performance at a reasonable level with near real-time operation. 2008 Elsevier B.V. All rights reserved.
Chemotherapy treatment and survival in older women with estrogen receptor-negative metastatic breast cancer: a population-based analysis.

UNLABELLED
To investigate the survival benefit associated with chemotherapy receipt in older women with estrogen receptor-negative (ER-) Stage IV breast cancer.


DESIGN
Observational, retrospective cohort study using Cox proportional hazards regression to determine effect of chemotherapy on hazard of all-cause mortality. The two samples were an overall sample (n=1,519) and a propensity score-matched sample (n=580) to control for selection to treatment receipt. Hazard ratios (HRs) and 95% confidence intervals (CIs) were obtained for regression models.


SETTING
U.S. women within the National Cancer Institute Surveillance, Epidemiology and End Results cancer registries (SEER) linked to Medicare enrollment and claims database.


PARTICIPANTS
Female Medicare beneficiaries aged 66 and older with Stage IV ER- breast cancer diagnosed between 1999 and 2005.


MEASUREMENTS
Outcome measure was all-cause death during the follow-up period. Survival was measured as time from breast cancer diagnosis until death or last follow-up date. Information on receipt of chemotherapy, defined as chemotherapy received within 6 months after diagnosis, was obtained from linked Medicare claims.


RESULTS
One thousand five hundred nineteen ER- women diagnosed with metastatic breast cancer were identified; 494 (33%) received chemotherapy. Chemotherapy was associated with a statistically significant survival benefit (HR=0.61, 95% CI=0.54-0.70). Age did not modify the survival benefit of chemotherapy.


CONCLUSION
Chemotherapy received within 6 months after diagnosis was associated with a 39% lower hazard of death within the time period for the study. These findings reflect chemotherapy use outside of the clinical trial setting and have important clinical and policy implications for the study of treatments in older women with advanced ER- breast cancer.
[Acupoint autohemotherapy for allergic rhinitis and its effect on serum IL-12 and IFN-gamma].

OBJECTIVE
To explore the clinical efficacy and the mechanism of acupoint autohemotherapy in the treatment of allergic rhinitis.


METHODS
Forty-five cases were randomized into an autohemotherapy group (24 cases) and a western medication group (21 cases). In the autohemotherapy group, the acupoint autohemotherapy was applied to the bilateral Dingchuan (EX-B 1), Fengmen (BL 12), Feishu (BL 13), Quchi (LI 11), Zusanli (ST 36) and the others. In the western medication group, loratadine tablets were prescribed. The patients were treated continuously for 3 months in both groups. The clinical symptom score was taken for the assessment of clinical efficacy. The enzyme-linked immunoadsordent assay (ELISA) was adopted to determine the contents of serum interferon-gamma (IFN-gamma) and interleukin-12 (IL-12).


RESULTS
The total effective rate was 83.3% (20/24) in the autohemotherapy group, which was obviously superior to 66.7% (14/21) in the western medication group (P < 0.05). After treatment, the clinical symptom scores of patients in the two groups were all reduced. The improvements in the scores of sneezing and clear nasal discharge in the autohemotherapy group were much more significant than those in the western medication group (both P < 0.05). After treatment, the serum IL-12 content of patients in the two groups was all increased to different extents as compared with that before treatment (both P < 0.05). In the autohemotherapy group, the serum IFN-gamma was increased after treatment (P < 0.05). In the western medication group, the serum IFN-gamma was not increased obviously after treatment (P > 0.05). The increase of the above index contents in the autohemotherapy group were more apparent than those in the western medication group (both P < 0.05).


CONCLUSION
The acupoint autohemotherapy relieves significantly the clinical symptoms of allergic rhinitis and the therapeutic effect is better than that with oral administration of loratadine tablets, which is probably relevant with the increase of serum IL-12 content and the promotion of IFN-gamma synthesis.