LLukas22/scidocs huggingface dataset:
Analysis of beat noise in coherent and incoherent time-spreading OCDMA

The effect of beat noise and other types of additive noise in time-spreading optical-code-division multiple-access (TS-OCDMA) networks is analyzed in this paper. By defining the coherent ratio kt, the ratio of the chip duration to the coherence time of the light source, TS-OCDMA systems are classified into incoherent, partially coherent, and coherent systems. The noise distributions and the bit-error rates are derived, and system performance is discussed for different cases. The performance of coherent systems is limited by the beat noise. With increasing kt, the effect of beat noise decreases in incoherent systems, and they eventually become free of beat noise. Possible solutions to the beat noise problem in coherent and partially coherent systems are also proposed and discussed.
Shape Segmentation Using Local Slippage Analysis

We propose a method for segmentation of 3D scanned shapes into simple geometric parts. Given an input point cloud, our method computes a set of components which possess one or more slippable motions: rigid motions which, when applied to a shape, slide the transformed version against the stationary version without forming any gaps. Slippable shapes include rotationally and translationally symmetrical shapes such as planes, spheres, and cylinders, which are often found as components of scanned mechanical parts. We show how to determine the slippable motions of a given shape by computing eigenvalues of a certain symmetric matrix derived from the points and normals of the shape. Our algorithm then discovers slippable components in the input data by computing local slippage signatures at a set of points of the input and iteratively aggregating regions with matching slippable motions. We demonstrate the performance of our algorithm for reverse engineering surfaces of mechanical parts.
Adding casein phosphopeptide-amorphous calcium phosphate to sports drinks to eliminate in vitro erosion.

PURPOSE
Enamel erosion can occur with frequent consumption of sports drinks. The purpose of this study was to determine a minimal concentration of casein phosphopeptide-stabilized amorphous calcium phosphate (CPP-ACP) which when added to a sports drink would eliminate such erosion in vitro.


METHODS
Human enamel specimens were immersed in: (1) the sports drink Powerade; (2) Poweradeplus 4 concentrations of CPP-ACP (0.063%, 0.09%, 0.125%, 0.25%); or (3) double deionized water. Windows of test and control enamel were profiled, and the enamel surface characteristics were examined under scanning electron microscopy (SEM).


RESULTS
The pH of test solutions increased and the titratable acidity decreased with increasing CPP-ACP concentrations. Erosive step lesions occurred in specimens immersed in Powerade (mean depth=38.70kA +/- 5.60), which were eliminated by the addition of CPP-ACP to Powerade at all test concentrations except 0.063% CPP-ACP. Microscopic surface irregularities on test enamel were observed, apparent as adherent granules or globules. These may represent redeposited mineral phases following mobilization of calcium and phosphate from CPP-ACP. Tasters in a taste panel could not distinguish Powerade from Powerade plus 0.125% CPP-ACP.


CONCLUSIONS
Adding casein phosphopeptide-stabilized amorphous calcium phosphate to the sports drink Powerade significantly reduced the beverage's erosivity without affecting the product's taste.
ForeGraph: Exploring Large-scale Graph Processing on Multi-FPGA Architecture

The performance of large-scale graph processing suffers from challenges including poor locality, lack of scalability, random access pattern, and heavy data conflicts. Some characteristics of FPGA make it a promising solution to accelerate various applications. For example, on-chip block RAMs can provide high throughput for random data access. However, large-scale processing on a single FPGA chip is constrained by limited on-chip memory resources and off-chip bandwidth. Using a multi-FPGA architecture may alleviate these problems to some extent, while the data partitioning and communication schemes should be considered to ensure the locality and reduce data conflicts. In this paper, we propose ForeGraph, a large-scale graph processing framework based on the multi-FPGA architecture. In ForeGraph, each FPGA board only stores a partition of the entire graph in off-chip memory. Communication over partitions is reduced. Vertices and edges are sequentially loaded onto the FPGA chip and processed. Under our scheduling scheme, each FPGA chip performs graph processing in parallel without conflicts. We also analyze the impact of system parameters on the performance of ForeGraph. Our experimental results on Xilinx Virtex UltraScale XCVU190 chip show ForeGraph outperforms state-of-the-art FPGA-based large-scale graph processing systems by 4.54x when executing PageRank on the Twitter graph (1.4 billion edges). The average throughput is over 900 MTEPS in our design and 2.03x larger than previous work.
High-level synthesis scheduling and allocation using genetic algorithms based on constructive topological scheduling techniques

In this article constructive scheduling methods combined with genetic algorithms are used to search for a suitable order to schedule the operations. The method is extended with an encoding capable of allocating supplementary resources during scheduling. This makes it very suitable in high-level synthesis strategies based on lower bound estimations techniques. Experiments and comparisons show high quality results and fast run times that outperform results produced by other heuristic scheduling methods
Bioaccumulation of heavy metals in marine organisms from the Romanian sector of the Black Sea.

The aim of this research was to study the accumulation of heavy metals (cadmium - Cd, lead - Pb, chromium - Cr, nickel - Ni, and copper - Cu) from water and sediments into living tissues of relevant marine species from different trophic levels of a food web, representative for shallow waters of the Romanian Black Sea Coast where the main anthropogenic impacts exist. The heavy metals concentrations were analysed by using an Atomic Absorption Spectrometer with graphite furnace, the results being further used to calculate the bioconcentration factors for a few key taxa like green and red algae, molluscs and fishes. Seven sampling sites influenced by anthropogenic pollution sources (municipal wastewater treatment plants and diffuse sources) were considered and a total of 300 samples were analysed for the period 2011-2012, this being the first unitary study for the Romanian Black Sea marine ecosystem. In 2011 and 2012 there were no significant differences between the sampling areas considering the heavy metals concentrations in water. For the sediments significant differences were observed between sampling sites for some heavy metals, namely Pb in 2011 and Pb, Cu and Cd in 2012, the highest concentrations being registered in the southern sector of the Romanian Black Sea shore, where the anthropogenic pollution sources are represented by the harbour and wastewater treatment plants. The values of the bioaccumulation factors (BCFsed) shows that algae are good accumulators for Cu>Pb>Ni>Cr>Cd, in comparison with BCFwater where the order of heavy metal accumulation was different: Cr>Ni>Pb>Cd>Cu. Molluscs have higher bioconcentration factors for Cu and Cd for sediments and for Cu and Ni for water. Rapana venosa accumulated more Cd and Cu. For fishes, Pb, Cu and Ni had the highest values in the tissues of benthonic species Mullus barbatus. In bivalve molluscs and fishes, in the majority of cases, there were not recorded exceeding mean concentrations as compared to the maximum allowed concentrations for Cd and Pb.
Adaptive Approaches on the Sliding Mode Control of Robot Manipulators

In this paper, adaptive algorithms on the sliding mode control for robust tracking control of robot manipulators are presented. The presented algorithms use adaptation laws for tuning both the sliding mode gain and the thickness of the boundary layer to reject a discontinuous control input, and to improve the tracking performance. It is shown that the robustness of the developed adaptive algorithms are guaranteed by the sliding mode control law and that the algorithms are globally convergent in the presence of disturbances and modeling uncertainties. Computer simulations are performed for a two-link manipulator, and the results show good properties of the proposed adaptive algorithms under large manipulator parameter uncertainties and disturbances.
Pharmacokinetics of once-daily etravirine without and with once-daily darunavir/ritonavir in antiretroviral-naive HIV type-1-infected adults.

BACKGROUND
A pharmacokinetic trial was conducted to evaluate the potential for once-daily etravirine in antiretroviral regimens without and with darunavir/ritonavir.


METHODS
During this multicentre, open-label, Phase IIa trial, treatment-naive patients aged > or =18 years with HIV type-1 (HIV-1) received etravirine 400 mg once daily with tenofovir disoproxil fumarate/emtricitabine 300/200 mg once daily from days 1-14; on days 15-28, darunavir/ritonavir 800/100 mg once daily was added. On day 29, etravirine was discontinued and patients continued with the other medications to day 42. Serial blood sampling for etravirine pharmacokinetics was performed over 24 h on day 14 and 28; patients fasted for > or =10 h prior to these visits.


RESULTS
Of 23 enrolled patients (male 87%, Caucasian 39%), pharmacokinetic profiles for etravirine were available for 21 and 20 patients on day 14 and 28, respectively. The plasma concentration-time profile and pharmacokinetics for etravirine were unchanged with or without darunavir/ritonavir. The mean maximum plasma concentration (C(max)) was reached 4 h after administration and was 790 and 801 ng/ml on day 14 and 28, respectively; mean area under the plasma concentration-time curve (AUC) from before administration to 24 h after administration was 10,410 ng*h/ml on day 14 and 10,720 ng*h/ml on day 28. In a post-hoc analysis, etravirine C(max) was higher, minimum plasma concentration was lower and AUC was similar when compared with etravirine 200 mg twice daily.


CONCLUSIONS
Addition of darunavir/ritonavir to etravirine, all dosed once daily, did not have a clinically significant effect on the pharmacokinetics of etravirine. Findings support further investigation of etravirine 400 mg once daily in HIV-1-infected patients. (Trial registration number NCT00534352.).
The role of disease management programs in the health behavior of chronically ill patients.

OBJECTIVE
Investigate the effects of disease management program (DMP) implementation on physical activity, smoking, and physical quality of life among chronically ill patients.


METHODS
This study used a mixed-methods approach involving qualitative (35 interviews with project managers) and quantitative (survey of patients from 18 DMPs) data collection. Questionnaire response rates were 51% (2010; 2619/5108) at T0 and 47% (2011; 2191/4693) at T1.


RESULTS
Physical activity and the percentage of smokers improved significantly over time, whereas physical quality of life declined. After adjusting for patients' physical quality of life at T0, age, educational level, marital status, and gender, physical activity at T0 (p<0.01), changes in physical activity (p<0.001), and percentage of smokers at T0 (p<0.05) predicted physical quality of life at T1. Project managers reported that DMPs improved patient-professional interaction. The ability to set more concrete targets improved patients' health behaviors.


CONCLUSIONS
DMPs appear to improve physical activity among chronically ill patients over time. Furthermore, (changes in) health behavior are important for the physical quality of life of chronically ill patients.


PRACTICE IMPLICATIONS
Redesigning care systems and implementing DMPs based on the chronic care model may improve health behavior among chronically ill patients.
CS364B: Frontiers in Mechanism Design Bonus Lecture: Gross Substitutes and Greedy Algorithms

where A = {j : q(j) > p(j)} is the of items whose prices have increased (in q relative to p). That is, whenever a bidder loses the items of S ∩ A because of being outbid, it still wants to retain the items S \ A it has, at the original prices. We saw several examples of GS valuations, including k-unit demand valuations, downward-sloping valuations for identical items, and so on. In this lecture, we insist that Definition 1.1 holds for all real-valued prices vectors, including those that with some negative prices. We also won’t need to assume that vi(∅) = 0. We only consider valuations that are monotone (S ⊆ T implies v(S) ≤ v(T )). ∗ c ©2014, Tim Roughgarden. †Department of Computer Science, Stanford University, 462 Gates Building, 353 Serra Mall, Stanford, CA 94305. Email: tim@cs.stanford.edu.
Implementing bedside handover: strategies for change management.

AIMS AND OBJECTIVES
To identify factors influencing change in two hospitals that moved from taped and verbal nursing handover to bedside handover.


BACKGROUND
Bedside handover is based on patient-centred care, where patients participate in communicating relevant and timely information for care planning. Patient input reduces care fragmentation, miscommunication-related adverse events, readmissions, duplication of services and enhances satisfaction and continuity of care.


DESIGN
Analysing change management was a component of a study aimed at developing a standard operating protocol for bedside handover communication. The research was undertaken in two regional acute care hospitals in two different states of Australia.


METHOD
Data collection included 532 semi-structured observations in six wards in the two hospitals and 34 in-depth interviews conducted with a purposive sample of nursing staff involved in the handovers. Observation and interview data were analysed separately then combined to generate thematic analysis of factors influencing the change process in the transition to bedside handover.


RESULTS AND CONCLUSION
Themes included embedding the change as part of the big picture, the need to link the project to standardisation initiatives, providing reassurance on safety and quality, smoothing out logistical difficulties and learning to listen. We conclude that change is more likely to be successful when it is part of a broader initiative such as a quality improvement strategy.


RELEVANCE TO CLINICAL PRACTICE
Nurses are generally supportive of quality improvement initiatives, particularly those aimed at standardising care. For successful implementation, change managers should be mindful of clinicians' attitudes, motivation and concerns and their need for reassurance when changing their practice. This is particularly important when change is dramatic, as in moving from verbal handover, conducted in the safety of the nursing office, to bedside handover where there is greater transparency and accountability for the accuracy and appropriateness of communication content and processes.
Severe encephalopathy with epilepsy in an infant caused by subclinical maternal pernicious anaemia: case report and review of the literature

Vitamin B12 deficiency is one of the major causes of megaloblastic anaemia with or without neurological symptoms. We report on a patient manifesting acute encephalopathy, epilepsy, microcephaly and megaloblastic anaemia at the age of 4 months. Vitamin B12 deficiency in the patient was due to subclinical pernicious anaemia of the mother who exhibited neither haematological nor neurological symptoms. Mother and child both had elevated methylmalonic acid in their urine which is a sensitive parameter of vitamin B12 deficiency. Vitamin B12 therapy resulted in arrest of convulsions within 24 h. There were no further seizures although the patient showed moderate mental retardation at the age of 7 years but a normal head circumference. Long-term MRI follow-up, performed at the age of 7 years, showed moderate enlargement of the ventricles with reduction of myelin and hypoplasia of the corpus callosum. Conclusion:vitamin B12 deficiency due to maternal pernicious anaemia should always be considered in the differential diagnosis of neurological symptoms in infants and especially in combination with megaloblastic anaemia. Since the age of onset and the duration of neurological symptoms may contribute to the development of long-term symptoms, early diagnosis and treatment is important for vitamin B12 deficient children.
Impact of diabetes on the risk stratification using stress single-photon emission computed tomography myocardial perfusion imaging in patients with symptoms suggestive of coronary artery disease.

BACKGROUND
Coronary artery disease can develop prematurely and is the leading cause of death among diabetics, making noninvasive risk stratification desirable.


METHODS AND RESULTS
Patients with symptoms of coronary artery disease who were undergoing stress myocardial perfusion imaging (MPI) from 5 centers were prospectively followed (2.5+/-1.5 years) for the subsequent occurrence of cardiac death, myocardial infarction (MI), and revascularization. Stress MPI results were categorized as normal or abnormal (fixed or ischemic defects and 1, 2, or 3 vessel distribution). Of 4755 patients, 929 (19.5%) were diabetic. Patients with diabetes, despite an increased revascularization rate, had 80 cardiac events (8.6%; 39 deaths and 41 MIs) compared with 172 cardiac events (4.5%; 69 deaths and 103 MIs) in the nondiabetic cohort (P<0.0001). Abnormal stress MPI was an independent predictor of cardiac death and MI in both populations. Diabetics with ischemic defects had an increased number of cardiac events (P<0.001), with the highest MI rates (17.1%) observed with 3-vessel ischemia. Similarly, a multivessel fixed defect was associated with the highest rate of cardiac death (13.6%) among diabetics. The unadjusted cardiac survival rate was lower for diabetic patients (91% versus 97%, P<0.001), but it became comparable once adjusted for the pretest clinical risk and stress MPI results. In multivariable Cox analysis, both ischemic and fixed MPI defects independently predicted cardiac death alone or cardiac death/MI. Diabetic women had the worst outcome for any given extent of myocardial ischemia.


CONCLUSIONS
In this large cohort of diabetics undergoing stress MPI, the presence and the extent of abnormal stress MPI independently predicted subsequent cardiac events. Using stress MPI in conjunction with clinical information can provide risk stratification of diabetic patients.
A Sub-600-mV, Fluctuation Tolerant 65-nm CMOS SRAM Array With Dynamic Cell Biasing

Fluctuation limitations on scaling CMOS SRAM cell transistor dimensions and operating voltages are demonstrated by measuring local stochastic distributions of 65-nm PDSOI CMOS SRAM cell storage node voltages during read, write, and retention modes of operation. These measurements reveal insights into terminal voltage dependencies of cell margin distributions - observations that are engaged to increase cell immunity to random VT fluctuations by several orders of magnitude by biasing the cell terminal voltages dynamically with a read-write asymmetry. Combinations of circuit techniques implementing these dynamic cell biasing schemes are demonstrated in a 9 kb times74 b PDSOI CMOS SRAM array with a conventional 65 nm SRAM cell and an ABIST. Measurements demonstrate these techniques to enable VMIN reductions of over 200 mV - lowering measured VMIN to 0.54 V and 0.38 V/0.50 V for single and dual VDD implementations, respectively. The techniques consume a 10%-12% overhead in area, impact performance marginally (<5%) and also enable over 50% reduction in cell leakage.
A phase 2 study of intravenous panobinostat in patients with castration-resistant prostate cancer

Panobinostat, a pan-deacetylase inhibitor, increases acetylation of proteins associated with growth and survival of malignant cells. This phase 2 study evaluated the efficacy of intravenous (IV) panobinostat in patients with castration-resistant prostate cancer (CRPC) who had previously received chemotherapy. The primary end point was 24-week progression-free survival. Secondary end points included safety, tolerability, and the proportion of patients with a prostate-specific antigen (PSA) decline. IV panobinostat (20 mg/m2) was administered to patients on days 1 and 8 of a 21-day cycle. Tumor response was assessed by imaging every 12 weeks (4 cycles) according to modified response evaluation criteria in solid tumors (Scher et al. in Clin Cancer Res 11:5223–5232, 23), and PSA response was defined as a 50 % decrease from baseline maintained for ≥4 weeks. Safety monitoring was routinely performed and included electrocardiogram monitoring. Of 35 enrolled patients, four (11.4 %) were alive without progression of disease at 24 weeks. PSA was evaluated in 34 (97.1 %) patients: five (14.3 %) patients demonstrated a decrease in PSA but none ≥50 %; one patient (2.9 %) had carcinoembryonic antigen as a marker of his prostate cancer, which declined by 43 %. Toxicities regardless of relationship to panobinostat included fatigue (62.9 %), thrombocytopenia (45.7 %), nausea (51.4 %), and decreased appetite (37.1 %). Despite promising preclinical data and scientific rationale, treatment with IV panobinostat did not show a sufficient level of clinical activity to pursue further investigation as a single agent in CRPC.
Screening for Depression Patients in Family Medicine

GOAL
The aims are to establish the prevalence of newfound, unidentified cases of depressive disorder by screening with the Becks Depression scale; To establish a comparative relationship with self-identified cases of depression in the patients in the family medicine; To assess the significance of the BDI in screening practice of family medicine.


PATIENTS AND METHODS
A prospective study was conducted anonymously by Beck's Depression scale (Beck Depression Questionnaire org.-BDI) and specially created short questionnaire. The study included 250 randomly selected patients (20-60 years), users of services in family medicine in "Dom Zdravlja" Zenica, and the final number of respondents with included in the study was 126 (51 male, 75 female; response or response rate 50.4%). Exclusion factor was previously diagnosed and treated mental disorder. Participation was voluntary and respondents acknowledge the validity of completing the questionnaire. BDI consists of 21 items. Answers to questions about symptoms were ranked according to the Likert type scale responses from 0-4 (from irrelevant to very much). Respondents expressed themselves on personal perception of depression, whether are or not depressed.


RESULTS
Depression was observed in 48% of patients compared to 31% in self estimate depression analyzed the questionnaires. The negative trend in the misrecognition of depression is -17% (48:31). Depression was significantly more frequent in unemployed compared to employed respondents (p = 0.001). The leading symptom in both sexes is the perception of lost hope (59% of cases).


CONCLUSION
All respondents in family medicine care in Zenica showed a high percentage of newly detected (17%) patients with previously unrecognized depression. BDI is a really simple and effective screening tool for the detection and identification of persons with symptoms of depression.