LLukas22/scidocs huggingface dataset:
The five-step lower blepharoplasty: blending the eyelid-cheek junction.

BACKGROUND
Lower lid blepharoplasty has potential for significant long-lasting complications and marginal aesthetic outcomes if not performed correctly, or if one disregards the anatomical aspects of the orbicularis oculi muscle. This has detracted surgeons from performing the technical maneuvers necessary for optimal periorbital rejuvenation. A simplified, "five-step" clinical approach based on sound anatomical principles is presented.


METHODS
A review of 50 lower lid blepharoplasty patients (each bilateral) using the five-step technique was conducted to delineate the efficacy in improving lower eyelid aesthetics. Digital images from 50 consecutive primary lower blepharoplasty patients (100 lower lids: 37 women and 13 men) were measured using a computer program with standardized data points that were later converted to ratios.


RESULTS
Of the 100 lower eyelid five-step blepharoplasties analyzed, complication rates were low and data points measured demonstrated improvements in all aesthetic parameters. The width and position of the tear trough, position of the lower lid relative to the pupil, and the intercanthal angle were all improved. There were no cases of lower lid malposition.


CONCLUSIONS
Aesthetic outcomes in lower lid blepharoplasty can be improved using a five-step technical sequence that addresses all of the anatomical findings. Lower lid blepharoplasty results are improved when (1) the supportive deep malar fat compartment is augmented; (2) lower lid orbicularis oculi muscle is preserved with minimal fat removal (if at all); (3) the main retaining structure (orbicularis retaining ligament) is selectively released; (4) lateral canthal support is established or strengthened (lateral retinacular suspension); and (5) minimal skin is removed.


CLINICAL QUESTION/LEVEL OF EVIDENCE
Therapeutic, IV.
Evaluation of a community intervention program in Japan using Framingham risk score and estimated 10-year coronary heart disease risk as outcome variables: a non-randomized controlled trial

BACKGROUND
Community-based programs are being widely adopted in the struggle to prevent cardiovascular diseases. No study has been conducted in Japan to evaluate the effects of a community-based health promotion program by using the Framingham risk score and 10-year CHD risk as outcome variables. The aim of the present study was to assess the effects of a program involving 6-month intervention and 18-month follow-up using such outcomes.


METHODS
Participants (n = 1,983, 39.5% women, mean age 63.4 years) were selected for the study in 2008. Of these 1,983, 347 (42.4% women) subjects received the 6-month intervention. The intervention included individual counseling and group sessions, among others. After 18 months, 1,278 participants (intervention group: 238, control group: 1,040) were followed up. Changes in the Framingham risk score and 10-year coronary heart disease (CHD) risk were evaluated. ANCOVA and multiple logistic models adjusted for baseline value, age, sex and intervention times were used.


RESULTS
The results showed that the differences in the Framingham risk score and mean 10-year CHD risk were significant in the intervention group compared with the control group after 6-month follow-up (-0.46 and -1.12, respectively) and were also significant after 18-month follow-up (-0.39 and -0.85, respectively). The proportion of those with intermediate 10-year CHD risk (> = 10%) was significantly lower at 6 months (OR 0.30, 95% CI 0.12-0.74) and at 18 months (OR 0.41, 95% CI 0.19-0.92).


CONCLUSIONS
The six-month intervention program effectively decreased estimated 10-year CHD risk and the effects were still present at 18-month follow-up.


TRIAL REGISTRATION
UMIN-CTR: UMIN000008163.
Children as partners with adults in their medical care.

AIMS
To investigate the seldom published views of children with type 1 diabetes about their condition and ways in which they share in managing their medical and health care with adults.


METHODS
Semi-structured, tape recorded interviews, during 2003, with a purposive sample of 24 children aged 3-12 years who have type I diabetes and who attend two inner London hospitals and one hospital in a commuter town.


RESULTS
The children reported high levels of understanding, knowledge, and skill gained from their experience of living with diabetes and constantly having to take account of the condition and their paediatrician's guidance. Their key goals were to be "normal" and "just get on with their lives".


DISCUSSION
The interviews showed that children's experiences of diabetes tended to enable them to make informed, "wise" decisions in their own best interests, even at a young age. They achieved a complicated balance between the sometimes competing goals of social health "being normal" and physiological health in controlling glycaemia. Their competence supports approaches in children's rights and in policy makers' aims that people with diabetes--including children--gain more knowledge, skills, and responsibility for their own care in partnership with healthcare professionals. Consent is usually considered in relation to surgery; however the children showed how they constantly dealt with decisions about consent or refusal, compliance with, or resistance to their prescribed treatment. Their health depends on their informed commitment to medical guidance; more research is needed about the daily realities of children's committed and responsible co-management of their chronic illness.
A Low-Cost Easy Operation 4-Cable Driven Parallel Manipulator

In this paper the design and kinematic performances are presented for a low-cost parallel manipulator with 4 driven cables. It has been conceived for an easy programming of its operation by properly formulating the Kinematics of the parallel architecture that uses cables. A prototype has been built and tests have experienced the feasibility of the system design and its operation.
Increased mindfulness is related to improved stress and mood following participation in a mindfulness-based stress reduction program in individuals with cancer.

BACKGROUND
Mindfulness-based stress reduction (MBSR) has demonstrated efficacy for alleviating cancer-related distress. Although theorized to be the means by which people improve, it is yet to be determined whether outcomes are related to the development or enhancement of mindfulness among participants. This study examined the effect of participation in an MBSR program on levels of mindfulness in a heterogeneous sample of individuals with cancer, and if these changes were related to improvements in stress and mood outcomes.


METHODS
In all, 268 individuals with cancer completed self-report assessments of stress and mood disturbances before and after participation in an 8-week MBSR program. Of these, 177 participants completed the Mindful Attention Awareness Scale and 91 participants completed the Five Facet Mindfulness Questionnaire, at both time points.


RESULTS
Levels of mindfulness on both measures increased significantly over the course of the program. These were accompanied by significant reductions in mood disturbance (55%) and symptoms of stress (29%). Increases in mindfulness accounted for a significant percentage of the reductions in mood disturbance (21%) and symptoms of stress (14%). Being aware of the present moment and refraining from judging inner experience were the 2 most important mindfulness skills for improvements of psychological functioning among cancer patients.


CONCLUSIONS
These results add to a growing literature measuring the impact of mindfulness and its relationship to improved psychological health. Moreover, specific mindfulness skills may be important in supporting these improvements.
Fruit recognition from images using deep learning

In this paper we introduce a new, high-quality, dataset of images containing fruits. We also present the results of some numerical experiment for training a neural network to detect fruits. We discuss the reason why we chose to use fruits in this project by proposing a few applications that could use such classifier.
Effect of emergency department crowding on outcomes of admitted patients.

STUDY OBJECTIVE
Emergency department (ED) crowding is a prevalent health delivery problem and may adversely affect the outcomes of patients requiring admission. We assess the association of ED crowding with subsequent outcomes in a general population of hospitalized patients.


METHODS
We performed a retrospective cohort analysis of patients admitted in 2007 through the EDs of nonfederal, acute care hospitals in California. The primary outcome was inpatient mortality. Secondary outcomes included hospital length of stay and costs. ED crowding was established by the proxy measure of ambulance diversion hours on the day of admission. To control for hospital-level confounders of ambulance diversion, we defined periods of high ED crowding as those days within the top quartile of diversion hours for a specific facility. Hierarchic regression models controlled for demographics, time variables, patient comorbidities, primary diagnosis, and hospital fixed effects. We used bootstrap sampling to estimate excess outcomes attributable to ED crowding.


RESULTS
We studied 995,379 ED visits resulting in admission to 187 hospitals. Patients who were admitted on days with high ED crowding experienced 5% greater odds of inpatient death (95% confidence interval [CI] 2% to 8%), 0.8% longer hospital length of stay (95% CI 0.5% to 1%), and 1% increased costs per admission (95% CI 0.7% to 2%). Excess outcomes attributable to periods of high ED crowding included 300 inpatient deaths (95% CI 200 to 500 inpatient deaths), 6,200 hospital days (95% CI 2,800 to 8,900 hospital days), and $17 million (95% CI $11 to $23 million) in costs.


CONCLUSION
Periods of high ED crowding were associated with increased inpatient mortality and modest increases in length of stay and costs for admitted patients.
Two Dosing Regimens of Certolizumab Pegol in Patients With Active Rheumatoid Arthritis

OBJECTIVE
To investigate clinical efficacy and safety of 2 certolizumab pegol (CZP) maintenance dosing regimens plus methotrexate (MTX) in active rheumatoid arthritis (RA) patients achieving the American College of Rheumatology 20% improvement criteria (ACR20) after the CZP 200 mg every 2 weeks open-label run-in period.


METHODS
DOSEFLEX (dosing flexibility) was a double-blind, placebo-controlled randomized study with an open-label run-in phase. During the run-in phase, all patients received CZP 400 mg (weeks 0, 2, and 4) and 200 mg every 2 weeks to week 16. Week 16 ACR20 responders were randomized 1:1:1 at week 18 to CZP 200 mg every 2 weeks, 400 mg every 4 weeks, or placebo.


RESULTS
A total of 209 (of 333) patients were randomized at week 18 (CZP: 200 mg, n = 70; 400 mg, n = 70; placebo, n = 69). Groups had similar baseline characteristics (week 0). Week 34 ACR20 response rates were comparable between the CZP 200 mg every 2 weeks and the 400 mg every 4 weeks groups (67.1% versus 65.2%), which was significantly higher than placebo (44.9%; P = 0.009 and P = 0.017). ACR50/70 and remission criteria were met more frequently in CZP groups than placebo at week 34, with similar responses between anti-tumor necrosis factor-experienced and naive patients. Improvements from baseline Disease Activity Score in 28 joints using the erythrocyte sedimentation rate and Health Assessment Questionnaire disability index scores were maintained in CZP groups from week 16 to 34 while worsening on placebo. Adverse event (AE) rates in the double-blind phase were 62.9% versus 60.9% versus 62.3%; serious AE rates were 7.1% versus 2.9% versus 0.0% (CZP 200 mg, 400 mg, and placebo groups).


CONCLUSION
In active RA patients with an incomplete MTX response, CZP 200 mg every 2 weeks and 400 mg every 4 weeks were comparable and better than placebo for maintaining clinical response to week 4 following a 16-week, open-label run-in phase.
Benefits of a Primary Care Clinic Co-Located and Integrated in a Mental Health Setting for Veterans With Serious Mental Illness

INTRODUCTION
Efficacy trials have shown that primary care co-located in the mental health setting improves the receipt of high-quality medical care among people with serious mental illness. We tested whether implementation of such a program affected health service use and cardiovascular risk factor control among veterans with serious mental illness who had previously demonstrated limited primary care engagement.


METHODS
We performed a cohort study of veterans enrolled in a co-located, integrated primary care clinic in the mental health outpatient unit through targeted chart review. Two successive 6-month periods in the year before and in the year following enrollment in the co-located primary care clinic were examined for primary care and emergency department use and for goal attainment of blood pressure, fasting blood lipids, body mass index (BMI), and, among patients with diabetes, hemoglobin A1c (HbA1c). We used repeated-measures logistic regression to analyze goal attainment and repeated measures Poisson regression to analyze service use.


RESULTS
Compared with the period before enrollment, the 97 veterans enrolled in the clinic had significantly more primary care visits during 6 months and significantly improved goal attainment for blood pressure, low-density lipoprotein cholesterol, triglycerides, and BMI. Changes with regard to goal attainment for high-density lipoprotein cholesterol and HbA1c were not significant.


CONCLUSION
Enrollment in a co-located, integrated clinic was associated with increased primary care use and improved attainment of some cardiovascular risk goals among veterans with serious mental illness. Such a clinic can be implemented effectively in the mental health setting.
Validation of the Institut Curie simplified prognostic score for breast cancer meningeal carcinomatosis.

Breast cancer is the leading nonhematologic cause of meningeal carcinomatosis (MC), a unusual metastatic site. Its treatment generally relies on intrathecally and/or systematically delivered chemotherapy, combined with radiotherapy or surgery when needed. However, the overall survival (OS) of patients with proven MC is short, generally no longer than 6 months after the diagnosis of MC [1]. A retrospective study on 91 breast cancer MC diagnosed and treated homogeneously by a high-dose intrathecal methotrexate regimen [2] at the Institut Curie (Paris, France) from 2000 to 2007 has been recently reported [3]. This study retrieved four adverse independent prognostic factors at MC diagnosis: performance status (PS) of three to four, elevated Cyfra 21-1 marker in the cerebrospinal fluid (CSF), negative hormone receptors (HR) status and more than three previous chemotherapy lines for metastatic disease. Two prognostic scores were derived from these results, based on the number of adverse prognostic factors: the complete score included the four prognostic factors, whereas the simplified score did not include CSF Cyfra 21-1 as its dosage is not made routinely in this setting. Both prognostic scores allowed to classify patients into three groups with poor, intermediate and good prognosis (median OS of 2, 4 and 12 months, respectively). These scores required further validation. A retrospective validation of the simplified prognostic score has been conducted in patients diagnosed with breast cancer MC at the Institut Jules Bordet (Brussels, Belgium), after approval of the local ethic committee. Briefly, the electronic file of each of the 926 patients who underwent CSF cytological analysis from 01/2000 to 07/2010 were screened manually for MC diagnosis (tumor cells in CSF): 88 patients had both breast letters to the editor Annals of Oncology
Histamine-1 receptor antagonism for treatment of insomnia.

OBJECTIVES
To evaluate the literature regarding the use of histamine-1 (H(1)) receptor antagonists and to describe their role in the treatment of insomnia in adult patients, including the elderly.


DATA SOURCES
Literature was identified via PubMed and Medline through April 1, 2012, using the search terms insomnia and sleep, each individually combined with histamine antagonist, tricyclic antidepressant, trazodone, mirtazapine, doxepin, amitriptyline, nortriptyline, trimipramine, doxylamine, diphenhydramine, and antihistamine.


STUDY SELECTION AND DATA EXTRACTION
Data included randomized double-blind trials that statistically evaluated H(1) receptor antagonist treatment in patients with insomnia compared with a placebo control or Food and Drug Administration-approved insomnia treatment. Trials selected evaluated sleep latency, wake after sleep onset, total sleep time, number of awakenings, and/or sleep efficiency in a subjective or objective manner. A total of 65 trials were evaluated, and 16 met inclusion criteria.


DATA SYNTHESIS
With the exception of low-dose doxepin (Silenor-Somaxon), trials evaluating the clinical effectiveness of H(1) receptor antagonists show mixed results and are limited by sample size and generalizability. Large, randomized, appropriately controlled trials are lacking, making it difficult to define the safety and efficacy of these agents. In contrast, low-dose doxepin has been shown to provide consistent sleep benefit compared with placebo.


CONCLUSION
Over-the-counter antihistamines may have a role for short-term insomnia treatment in younger adults, but tolerance develops rapidly. Mirtazapine should not be used solely for the treatment of insomnia. Sedating antidepressants can be considered after failure of first-line insomnia treatments. Patients taking these agents chronically should be evaluated for continued efficacy and potential harm. Low-dose doxepin may have a unique role in the treatment of insomnia in elderly patients given its tolerability, documented efficacy, and lack of important adverse effects.
Randomised controlled trial of a tailored information pack for patients undergoing surgery and treatment for rectal cancer.

PURPOSE
To evaluate the effects of a tailored information package for rectal cancer patients on satisfaction with information, anxiety and depression and readjustment.


METHOD
The study used a randomised control trial method. Seventy six patients undergoing surgery and treatment for rectal cancer were randomly assigned to an intervention (n = 43) or control group (n = 33). The intervention group received an information pack tailored according to their treatment plan and preferred information. The control group received the information currently given to these patients. Satisfaction with information was measured using the Patient Satisfaction with Cancer Treatment Education (PSCaTE) scale, anxiety and depression were measured using the Hospital Anxiety and Depression Scale (HADS) and readjustment was measured using the Reintegration to Normal Living Index, at three time points.


RESULTS
There was a statistically significant difference between the intervention and control group on pre and post intervention scores with patients in the intervention group expressing a higher level of satisfaction with information than those in the control group at Times 2 and 3 (p = 0.00 for both). The intervention group also had a significantly lower anxiety score than the control group at Time 3 (p = 0.03). There was no difference between depression and readjustment scores in the two groups.


CONCLUSION
The results support the hypothesis that a tailored information pack for patients with rectal cancer will positively affect satisfaction with information. These results will enhance the knowledge base surrounding the provision of tailored information to specific patient groups.
Ultra-Resolving Face Images by Discriminative Generative Networks

www.PosterPresentations.com Conventional face super-resolution methods, also known as face hallucination, become very fragile when the input low-resolution image size is too small and upscaling factors are large. To address these shortcomings, we present a discriminative generative network that can ultraresolve a very low resolution face image of size 16×16 pixels to its 8x larger version by reconstructing 64 pixels from a single pixel. We introduce a pixel-wise L2 regularization term to the generative model and exploit the feedback of the discriminative network to make the upsampled face images more similar to real ones. In our framework, the discriminative network learns the essential constituent parts of the faces and the generative network blends these parts in the most accurate fashion to the input image. Our method can ultra-resolve a wide range of very low-resolution images directly regardless of pose and facial expression variations. Extensive experimental evaluations demonstrate that the presented ultra-resolution by discriminative generative networks (UR-DGN) achieves more appealing results than the state-of-the-art. ABSTRACT
Ecotourism and the empowerment of local communities

This research note considers ways in which we may better understand how ecotourism ventures impact on the lives of people living in, and around, the environments which ecotourists frequent. From a development perspective, ecotourism ventures should only be considered ‘successful’ if local communities have some measure of control over them and if they share equitably in the benefits emerging from ecotourism activities. An empowerment framework is proposed as a suitable mechanism for aiding analysis of the social, economic, psychological and political impacts of ecotourism on local communities. ( 1999 Elsevier Science Ltd. All rights reserved.
Detecting friendly, flirtatious, awkward, and assertive speech in speed-dates

Automatically detecting human social intentions and attitudes from spoken conversation is an important task for speech processing nd social computing. We describe a system for detecting interpersonal stance: whether a speaker is flirtatious, friendly, awkward, or ssertive. We make use of a new spoken corpus of over 1000 4-min speed-dates. Participants rated themselves and their interlocutors or these interpersonal stances, allowing us to build detectors for style both as interpreted by the speaker and as perceived by the earer. We use lexical, prosodic, and dialog features in an SVM classifier to detect very clear styles (the strongest 10% in each stance) ith up to 75% accuracy on previously seen speakers (50% baseline) and up to 59% accuracy on new speakers (48% baseline). feature analysis suggests that flirtation is marked by joint focus on the woman as a target of the conversation, awkwardness by ecreased speaker involvement, and friendliness by a conversational style including other-directed laughter and appreciations. Our ork has implications for our understanding of interpersonal stance, their linguistic expression, and their automatic extraction. 2012 Elsevier Ltd. All rights reserved.