LLukas22/scidocs huggingface dataset:
Collisions of the Second Kind between Ions and Atoms or Molecules

SOME experiments dealing with collisions of the second kind between ions and atoms or molecules have been performed independently and simultaneously in two different laboratories—one at Princeton University and one at the University of California. Through correspondence the different investigators have learned of each other's results and have decided to present jointly, in this letter, a preliminary report of this phenomenon, which heretofore has been unknown. In both researches, the apparatus used are essentially those described in the positive ray experiments by Smyth (Proc. Roy. Soc. and Phys. Rev.) and by Hogness and Lunn (Phys. Rev.). One set of experiments is the preliminary stage of a complete study of the whole phenomenon; the other is incidental to work on the positive ray analysis of nitric oxide.
Theory and Algorithms for Forecasting Time Series

We present data-dependent learning bounds for the general scenario of non-stationary nonmixing stochastic processes. Our learning guarantees are expressed in terms of a datadependent measure of sequential complexity and a discrepancy measure that can be estimated from data under some mild assumptions. We also also provide novel analysis of stable time series forecasting algorithm using this new notion of discrepancy that we introduce. We use our learning bounds to devise new algorithms for non-stationary time series forecasting for which we report some preliminary experimental results. An extended abstract has appeared in (Kuznetsov and Mohri, 2015).
From Wearable Sensors to Smart Implants-–Toward Pervasive and Personalized Healthcare

Objective: This paper discusses the evolution of pervasive healthcare from its inception for activity recognition using wearable sensors to the future of sensing implant deployment and data processing. Methods: We provide an overview of some of the past milestones and recent developments, categorized into different generations of pervasive sensing applications for health monitoring. This is followed by a review on recent technological advances that have allowed unobtrusive continuous sensing combined with diverse technologies to reshape the clinical workflow for both acute and chronic disease management. We discuss the opportunities of pervasive health monitoring through data linkages with other health informatics systems including the mining of health records, clinical trial databases, multiomics data integration, and social media. Conclusion: Technical advances have supported the evolution of the pervasive health paradigm toward preventative, predictive, personalized, and participatory medicine. Significance: The sensing technologies discussed in this paper and their future evolution will play a key role in realizing the goal of sustainable healthcare systems.
3D virtual "smart home" user interface

In contrast to the rapid development of home automation equipment and ‘smart home’ capabilities, comparatively less attention has been paid to the development of comprehensive, comfortable and self-explaining user interfaces. This is acknowledged to be an important obstacle for the broad success of smart home ideas and products. In order to make home automation desirable and economically feasible, it is vital to improve the attractivity, intuitivity and adaptivity of the user-home interaction taking advantage from modern information technologies such as Virtual Reality technology and downloadable hypertext documents. The user interface is augmented by the use of a virtual environment in conjunction with the physical environment adding information from different systems and sensors in the home, based on virtual environment activities. In this paper we describe a powerful graphical interface created with standard 3D programming tools to control and supervise the household. A number of features implemented in a prototype and implementation aspects will be described.
Comment on "Observation of superluminal behaviors in wave propagation".

Two Comments on the Letter by D. Mugnai, A. Ranfagni, and R. Ruggeri, Phys.Rev.Lett.84, 4830 (2000).
Linking WordNet to 3 D Shapes

We describe a project to link the Princeton WordNet to 3D representations of real objects and scenes. The goal is to establish a dataset that helps us to understand how people categorize everyday common objects via their parts, attributes, and context. This paper describes the annotation and data collection effort so far as well as ideas for future work.
Knowledge, attitudes and practices of Ugandan men regarding prostate cancer.

BACKGROUND
The incidence of prostate cancer in Uganda is one of the highest recorded in Africa. Prostate cancer is the most common cancer among men in Uganda.


OBJECTIVE
This study assessed the current knowledge, attitudes and practices of adult Ugandan men regarding prostate cancer.


SUBJECTS AND METHODS
We conducted a descriptive cross-sectional study using interviewer administered questionnaires and focus group discussions among 545 adult men aged 18-71 years, residing in Kampala, the capital of Uganda. Quantitative data were analyzed with SPSS version 20. Qualitative data were collected using audio recorded focus group discussions, transcribed and analyzed by clustering into themes.


RESULTS
The majority of the respondents (324, 59.4%) were aged 18-28 years, 295 (54.1%) had heard about prostate cancer and 250 (45.9%) had never heard about it. The commonest source of information about prostate cancer was the mass media. Only 12.5% of the respondents obtained information about prostate cancer from a health worker, 37.4% did not know the age group that prostate cancer affects and 50.2% could not identify any risk factor for prostate cancer. Participants in the focus group discussions confused prostate cancer with gonorrhea and had various misconceptions about the causes of prostate cancer. Only 10.3% of the respondents had good knowledge of the symptoms of prostate cancer and only 9% knew about serum prostate specific antigen (PSA) testing. Although 63.5% thought they were susceptible to prostate cancer, only 22.9% considered getting and only 3.5% had ever undergone a serum PSA test.


CONCLUSION
There was generally poor knowledge and several misconceptions regarding prostate cancer and screening in the study population. Community based health education programs about prostate cancer are greatly needed for this population.
Continuous positive airway pressure with helmet versus mask in infants with bronchiolitis: an RCT.

BACKGROUND
Noninvasive continuous positive airway pressure (CPAP) is usually applied with a nasal or facial mask to treat mild acute respiratory failure (ARF) in infants. A pediatric helmet has now been introduced in clinical practice to deliver CPAP. This study compared treatment failure rates during CPAP delivered by helmet or facial mask in infants with respiratory syncytial virus-induced ARF.


METHODS
In this multicenter randomized controlled trial, 30 infants with respiratory syncytial virus-induced ARF were randomized to receive CPAP by helmet (n = 17) or facial mask (n = 13). The primary endpoint was treatment failure rate (defined as due to intolerance or need for intubation). Secondary outcomes were CPAP application time, number of patients requiring sedation, and complications with each interface.


RESULTS
Compared with the facial mask, CPAP by helmet had a lower treatment failure rate due to intolerance (3/17 [17%] vs 7/13 [54%], P = .009), and fewer infants required sedation (6/17 [35%] vs 13/13 [100%], P = .023); the intubation rates were similar. In successfully treated patients, CPAP resulted in better gas exchange and breathing pattern with both interfaces. No major complications due to the interfaces occurred, but CPAP by mask had higher rates of cutaneous sores and leaks.


CONCLUSIONS
These findings confirm that CPAP delivered by helmet is better tolerated than CPAP delivered by facial mask and requires less sedation. In addition, it is safe to use and free from adverse events, even in a prolonged clinical setting.
Combination of flavonoids with Centella asiatica and Melilotus for diabetic cystoid macular edema without macular thickening.

PURPOSE
The purpose of this study was to evaluate the orally administered combination of flavonoids desmin and troxerutin with Centella asiatica and Melilotus for the treatment of diabetic cystoid macular edema (CME) without macular thickening.


METHODS
In this prospective, interventional, controlled study, 40 consecutive patients with type 2 diabetes and CME without macular thickening at optical coherence tomography were randomized into 2 groups of 20 subjects each (treatment and control groups). The treatment group received an oral combination of desmin (300 mg/day) and troxerutin (300 mg/day) with C. asiatica (30 mg/die) and Melilotus (160 mg/die) for 14 months. Best collected visual acuity, central retinal thickness at optical coherence tomography, retinal sensitivity (RS), and stability of fixation at microperimetry were measured at baseline and monthly for 14 months.


RESULTS
In both groups, mean best collected visual acuity, central retinal thickness, and stability of fixation did not show differences during follow-up (P > 0.05). At month 14, the RS was greater in the treated group (P = 0.01) and was significantly reduced in the control group only (P < 0.001). Five eyes in the study group showed disappearance of the intraretinal cysts after a mean time of 3.5 ± 0.3 months, which persisted in the following months. These 5 eyes presented a greater RS at each follow-up visit when compared with the control group (P < 0.05). Anatomic improvement was never reported in the control group.


CONCLUSIONS
The orally administered combination of flavonoids, C. asiatica, and Melilotus could be beneficial in preserving RS in diabetic CME without macular thickening.
Regulatory Effect of Iguratimod on the Balance of Th Subsets and Inhibition of Inflammatory Cytokines in Patients with Rheumatoid Arthritis

OBJECTIVE
To expand upon the role of iguratimod (T-614) in the treatment of rheumatoid arthritis (RA), we investigated whether the Th1, Th17, follicular helper T cells (Tfh), and regulatory T cells (Treg) imbalance could be reversed by iguratimod and the clinical implications of this reversal.


METHODS
In this trial, 74 patients were randomized into iguratimod-treated (group A) and control (broup B) group for a 24-week treatment period. In the subsequent 28 weeks, both groups were given iguratimod. Frequencies of Th1, Th17, Tfh, and Treg were quantified using flow cytometry, and serum cytokines were detected by enzyme-linked immunosorbent assay. mRNA expression of cytokines and transcriptional factor were quantified by RT-PCR. The composite Disease Activity Score, erythrocyte sedimentation rate, and C-reactive protein were assessed at each visit.


RESULT
The clinical scores demonstrated effective suppression of disease after treatment with iguratimod. In addition, iguratimod downregulated Th1, Th17-type response and upregulated Treg. Furthermore, the levels of Th1, Th17, and Tfh associated inflammatory cytokines and transcription factors were reduced after treatment with iguratimod, while the levels of Treg associated cytokines and transcription factors were increased.
Prognostic impact of the addition of ventilatory efficiency to the Seattle Heart Failure Model in patients with heart failure.

BACKGROUND
The Seattle Heart Failure Model (SHFM) is a multivariable model with proven prognostic value. Cardiopulmonary exercise testing (CPX) and neurohormonal markers (eg, B-type natriuretic peptide [BNP]) are also well accepted assessment techniques in the HF population and have both demonstrated robust prognostic value. The purpose of this investigation was to assess the combined prognostic value of the SHFM and CPX.


METHODS AND RESULTS
This study included all 453 patients enrolled in the Multicenter In-Sync Randomized Clinical Evaluation (MIRACLE) trial. Baseline SHFM and CPX were used. Both peak oxygen consumption (VO(2)) and ventilatory efficiency (VE/VCO(2)) were determined. In a univariate Cox proportional model analysis, SHFM and log-transformed peak VE/VCO(2) were stronger predictors of 6-month mortality (both P < .001) than log-transformed BNP (P = .013) or peak VO(2) (P = .066). In a multivariable Cox proportional hazards model, neither peak VO(2) nor BNP were independent predictors when added to the SHFM (P > .1). Conversely, peak VE/VCO(2) was a strong independent predictor when added to the SHFM, with an increase in the Cox proportional hazards model Wald χ(2) from 22.7 for SHFM alone to 33.8 with inclusion of log-transformed peak VE/VCO(2) (P < .0001) and significant changes in the net reclassification improvement and integrated discrimination index (both P < .002).


CONCLUSIONS
These results indicate that the SHFM and peak VE/VCO(2) work synergistically to improve prognostic resolution. Further investigation is needed to continue to optimize multivariable prognostic models in patients with HF, a chronic disease population that continues to suffer from a high adverse event rate despite advances in medical care.
A Fuzzy Game Theoretic Approach to Multi-Agent Coordination

Game theoretic decision making is a practical approach to multiagent coordination. Rational agents may make decisions based on different principles of rationality assumptions that usually involve knowledge of how other agents might move. After formulating a game matrix of utility entries of possible combination of moves from both agents, agents can reason which combination is the equilibrium. Most previous game theoretic works treat the utility values qualitatively (i.e., consider only the order of the utility values). This is not practical since the utility values are usually approximate and the differences between utility values are somewhat vague. In this paper, we present a fuzzy game theoretic decision making mechanism that can deal with uncertain utilities. We thus construct a fuzzy-theoretic game framework under both the fuzzy theory and the game theory. The notions of fuzzy dominant relations, fuzzy Nash equilibrium, and fuzzy strategies are defined and fuzzy reasoning are carried out in agent decision making. We show that a fuzzy strategy can perform better than a mixed strategy in traditional game theory in dealing with more than one Nash equilibrium games.
Aminophylline inhibits adaptation to ischaemia during angioplasty. Role of adenosine in ischaemic preconditioning.

UNLABELLED
The ability of brief periods of ischaemia to protect the heart from subsequent ischaemia has been termed "ischaemic preconditioning'. In order to assess the role of adenosine receptor stimulation in this phenomenon we studied the ischaemic preconditioning effect during angioplasty in 10 control patients and in 10 patients pre-treated with 5 mg.kg-1 aminophylline, an adenosine receptor antagonist. The ischaemic response was assessed by analysis of the intracoronary electrocardiogram every 10 s during three consecutive inflations of 90 s with a reperfusion time of 180 s. The severity of transmural local ischaemia was expressed as the magnitude of the ST segment shift in relation to the time during each inflation. The control patients showed an improved tolerance to myocardial ischaemia: ST segment shift decreased from 1.42 +/- 0.49 mV at the end of the first inflation to 1.03 +/- 0.44 mV at the end of the third inflation (P < 0.001). However, in patients pre-treated with aminophylline, the ischaemic response was not significantly different during three inflations.


CONCLUSION
Aminophylline inhibits ischaemic preconditioning, as assessed by analysis of the intracoronary. ST segment changes during angioplasty. This suggests that ischaemic preconditioning is mediated by adenosine receptor stimulation in humans.
Is computer science science?

Computer science meets every criterion for being a science, but it has a self-inflicted credibility problem.
A New Multidisciplinary Home Care Telemedicine System to Monitor Stable Chronic Human Immunodeficiency Virus-Infected Patients: A Randomized Study

BACKGROUND
Antiretroviral therapy has changed the natural history of human immunodeficiency virus (HIV) infection in developed countries, where it has become a chronic disease. This clinical scenario requires a new approach to simplify follow-up appointments and facilitate access to healthcare professionals.


METHODOLOGY
We developed a new internet-based home care model covering the entire management of chronic HIV-infected patients. This was called Virtual Hospital. We report the results of a prospective randomised study performed over two years, comparing standard care received by HIV-infected patients with Virtual Hospital care. HIV-infected patients with access to a computer and broadband were randomised to be monitored either through Virtual Hospital (Arm I) or through standard care at the day hospital (Arm II). After one year of follow up, patients switched their care to the other arm. Virtual Hospital offered four main services: Virtual Consultations, Telepharmacy, Virtual Library and Virtual Community. A technical and clinical evaluation of Virtual Hospital was carried out.


FINDINGS
Of the 83 randomised patients, 42 were monitored during the first year through Virtual Hospital (Arm I) and 41 through standard care (Arm II). Baseline characteristics of patients were similar in the two arms. The level of technical satisfaction with the virtual system was high: 85% of patients considered that Virtual Hospital improved their access to clinical data and they felt comfortable with the videoconference system. Neither clinical parameters [level of CD4+ T lymphocytes, proportion of patients with an undetectable level of viral load (p = 0.21) and compliance levels >90% (p = 0.58)] nor the evaluation of quality of life or psychological questionnaires changed significantly between the two types of care.


CONCLUSIONS
Virtual Hospital is a feasible and safe tool for the multidisciplinary home care of chronic HIV patients. Telemedicine should be considered as an appropriate support service for the management of chronic HIV infection.


TRIAL REGISTRATION
Clinical-Trials.gov: NCT01117675.
Factors affecting shrivelling and friction discolouration of pears (Pyrus communis L. )

The influence of variables (harvesting date, fruit size and storage duration) has been studied on the occurrence and susceptibility of shrivelling in ‘Packham’s Triumph’, ‘Beurré Bosc’ and ‘Forelle’ pears. The periods during simulated postharvest handling that proved the most conducive were those of high temperatures (i.e. after harvest, packing, recooling and shelf life). These short periods of relative high temperatures increased the rate of transpiration to such a level that high rates of weight loss were recorded. The contribution of transpiration to the total degree of weight loss far outweighed that of respiration. Early harvested (i.e. fruit of inferior maturity) and small fruit were more susceptible to shrivel and showed visual signs of shrivel before larger, more mature fruit did. The surface area to volume ratio determined the rate at which transpiration could take place. The smaller the fruit, the bigger the ratio and the higher the risk of experiencing shrivel. This renders the pear neck very susceptible to weight loss and subsequent shrivel. The highest rate of weight loss, at 18 °C, was recorded for ‘Beurré Bosc’ (0.43 %.day) followed by ‘Forelle’ (0.35 %.day). However, ‘Packham’s Triumph’ required the least amount of time to display signs of shrivel (10 days). This can be attributed to the prominent shape of this particular pear’s neck. Average percentage moisture loss required before shrivel was visible ranged from 2.5 %, 3.9 % and 4.4 % for ‘Packham’s Triumph’, ‘Beurré Bosc’ and ‘Forelle’, respectively. Sealing of the fruit stem reduced the amount of moisture that was lost through it and extended the possible shelf life of the pears. This was most notable in ‘Beurré Bosc’ and ‘Packham’s Triumph’.
Application of the new GOLD COPD staging system to a US primary care cohort, with comparison to physician and patient impressions of severity

BACKGROUND
In 2011, the traditional Global Initiative for Chronic Obstructive Lung Disease (GOLD) COPD spirometry-based severity classification system was revised to also include exacerbation history and COPD Assessment Test (CAT) and modified Medical Research Council Dyspnea Scale (mMRC) scores. This study examined how COPD patients treated in primary care are reclassified by the new GOLD system compared to the traditional system, and each system's level of agreement with patient's or physician's severity assessments.


METHODS
In this US multicenter cross-sectional study, COPD patients were recruited by 83 primary care practitioners (PCPs) to complete spirometry testing and a survey. Patients were classified by the traditional spirometry-based system (stages 1-4) and under the new system (grades A, B, C, D) using spirometry, exacerbation history, mMRC, and/or CAT results. Concordance between physician and patient-reported severity, spirometry stage, and ABCD grade based on either mMRC or CAT scores was examined.


RESULTS
Data from 445 patients with spirometry-confirmed COPD were used. As compared to the traditional system, the GOLD mMRC system reclassifies 47% of patients, and GOLD CAT system reclassifies 41%, but the distributions are very different. The GOLD mMRC system resulted in relatively equal distributions by ABCD grade (33%, 22%, 19%, 26%, respectively), but the GOLD CAT system put most into either B or D groups (9%, 45%, 4%, and 42%). The addition of exacerbation history reclassified only 19 additional patients. Agreement between PCPs' severity rating or their patients' self-assessment and the new ABCD grade was very poor (κ=0.17 or less).


CONCLUSION
As compared to the traditional system, the GOLD 2011 multidimensional system reclassified nearly half of patients, but how they were reclassified varied greatly by whether the mMRC or CAT questionnaire was chosen. Either way, the new system had little correlation with the PCPs or their patients' impressions about the COPD severity.
Establishing reference values for central blood pressure and its amplification in a general healthy population and according to cardiovascular risk factors.

AIMS
Estimated central systolic blood pressure (cSBP) and amplification (Brachial SBP-cSBP) are non-invasive measures potentially prognostic of cardiovascular (CV) disease. No worldwide, multiple-device reference values are available. We aimed to establish reference values for a worldwide general population standardizing between the different available methods of measurement. How these values were significantly altered by cardiovascular risk factors (CVRFs) was then investigated.


METHODS AND RESULTS
Existing data from population surveys and clinical trials were combined, whether published or not. Reference values of cSBP and amplification were calculated as percentiles for 'Normal' (no CVRFs) and 'Reference' (any CVRFs) populations. We included 45,436 subjects out of 82,930 that were gathered from 77 studies of 53 centres. Included subjects were apparently healthy, not treated for hypertension or dyslipidaemia, and free from overt CV disease and diabetes. Values of cSBP and amplification were stratified by brachial blood pressure categories and age decade in turn, both being stratified by sex. Amplification decreased with age and more so in males than in females. Sex was the most powerful factor associated with amplification with 6.6 mmHg (5.8-7.4) higher amplification in males than in females. Amplification was marginally but significantly influenced by CVRFs, with smoking and dyslipidaemia decreasing amplification, but increased with increasing levels of blood glucose.


CONCLUSION
Typical values of cSBP and amplification in a healthy population and a population free of traditional CVRFs are now available according to age, sex, and brachial BP, providing values included from different devices with a wide geographical representation. Amplification is significantly influenced by CVRFs, but differently in men and women.