LLukas22/scidocs huggingface dataset:
Future of brain stimulation: new targets, new indications, new technology.

In the last quarter of a century, DBS has become an established neurosurgical treatment for Parkinson's disease (PD), dystonia, and tremors. Improved understanding of brain circuitries and their involvement in various neurological and psychiatric illnesses, coupled with the safety of DBS and its exquisite role as a tool for ethical study of the human brain, have unlocked new opportunities for this technology, both for future therapies and in research. Serendipitous discoveries and advances in structural and functional imaging are providing abundant "new" brain targets for an ever-increasing number of pathologies, leading to investigations of DBS in diverse neurological, psychiatric, behavioral, and cognitive conditions. Trials and "proof of concept" studies of DBS are underway in pain, epilepsy, tinnitus, OCD, depression, and Gilles de la Tourette syndrome, as well as in eating disorders, addiction, cognitive decline, consciousness, and autonomic states. In parallel, ongoing technological development will provide pulse generators with longer battery longevity, segmental electrode designs allowing a current steering, and the possibility to deliver "on-demand" stimulation based on closed-loop concepts. The future of brain stimulation is certainly promising, especially for movement disorders-that will remain the main indication for DBS for the foreseeable future-and probably for some psychiatric disorders. However, brain stimulation as a technique may be at risk of gliding down a slippery slope: Some reports indicate a disturbing trend with suggestions that future DBS may be proposed for enhancement of memory in healthy people, or as a tool for "treatment" of "antisocial behavior" and for improving "morality."
MODELING AND IMPLEMENTATION OF CONTROLLER FOR SWITCHED RELUCTANCE MOTOR WITH AC SMALL SIGNAL MODEL

(ABSTRACT) As traditional control schemes, open-loop Hysteresis and closed-loop pulse-width-modulation (PWM) have been used for the switched reluctance motor (SRM) current controller. The Hysteresis controller induces large unpleasant audible noises because it needs to vary the switching frequency to maintain constant Hysteresis current band. In contract, the PWM controller is very quiet but difficult to design proper gains and control bandwidth due to the nonlinear nature of the SRM. In this thesis, the ac small signal modeling technique is proposed for linearization of the SRM model such that a conventional PI controller can be designed accordingly for the PWM current controller. With the linearized SRM model, the duty-cycle to output transfer function can be derived, and the controller can be designed with sufficient stability margins. The proposed PWM controller has been simulated to compare the performance against the conventional Hysteresis controller based system. It was found that through the frequency spectrum analysis, the noise spectra in audible range disappeared with the fixed switching frequency PWM controller, but was pronounced with the conventional Hysteresis controller. A hardware prototype is then implemented with digital signal processor to verify the quiet nature of the PWM controller when running at 20 kHz switching frequency. The experimental results also indicate a stable current loop operation.
Sexual behaviour of lesbians and bisexual women.

OBJECTIVES
To provide data about the sexual histories of a large sample of lesbians and bisexual women, to inform those who provide health care or carry out research with women who may be sexually active with other women.


DESIGN
Cross sectional survey.


SETTING/SUBJECTS
803 lesbians and bisexual women attending, as new patients, lesbian sexual health clinics, and 415 lesbians and bisexual women from a community sample.


MAIN OUTCOME MEASURES
Self reported sexual history and sexual practice with both male and female partners.


RESULTS
98% of the whole sample gave a history of sexual activity with women, 83% within the past year, with a median of one female partner in that year. 85% of the sample reported sexual activity with men; for most (70%) this was 4 or more years ago. First sexual experience tended to be with a man (median 18 years old), with first sexual experience with a woman a few years later (median 21 years). Oral sex, vaginal penetration with fingers, and mutual masturbation were the most commonly reported sexual practices between women. Vaginal penetration with penis or fingers and mutual masturbation were the most commonly reported sexual activities with men.


CONCLUSIONS
These data from the largest UK survey of sexual behaviour between women to date demonstrate that lesbians and bisexual women may have varied sexual histories with both male and female partners. A non-judgmental manner and careful sexual history taking without making assumptions should help clinicians to avoid misunderstandings, and to offer appropriate sexual health advice to lesbians and bisexual women.
Using Discriminant Eigenfeatures for Image Retrieval

|This paper describes the automatic selection of features from an image training set using the theories of multi-dimensional linear discriminant analysis and the associated optimal linear projection. We demonstrate the eeectiveness of these Most Discriminating Features for view-based class retrieval from a large database of widely varying real-world objects presented as \well-framed" views, and compare it with that of the principal component analysis.
The developmental effects of media-ideal internalization and self-objectification processes on adolescents’ negative body-feelings, dietary restraint, and binge eating

Despite accumulated experimental evidence of the negative effects of exposure to media-idealized images, the degree to which body image, and eating related disturbances are caused by media portrayals of gendered beauty ideals remains controversial. On the basis of the most up-to-date meta-analysis of experimental studies indicating that media-idealized images have the most harmful and substantial impact on vulnerable individuals regardless of gender (i.e., “internalizers” and “self-objectifiers”), the current longitudinal study examined the direct and mediated links posited in objectification theory among media-ideal internalization, self-objectification, shame and anxiety surrounding the body and appearance, dietary restraint, and binge eating. Data collected from 685 adolescents aged between 14 and 15 at baseline (47 % males), who were interviewed and completed standardized measures annually over a 3-year period, were analyzed using a structural equation modeling approach. Results indicated that media-ideal internalization predicted later thinking and scrutinizing of one’s body from an external observer’s standpoint (or self-objectification), which then predicted later negative emotional experiences related to one’s body and appearance. In turn, these negative emotional experiences predicted subsequent dietary restraint and binge eating, and each of these core features of eating disorders influenced each other. Differences in the strength of these associations across gender were not observed, and all indirect effects were significant. The study provides valuable information about how the cultural values embodied by gendered beauty ideals negatively influence adolescents’ feelings, thoughts and behaviors regarding their own body, and on the complex processes involved in disordered eating. Practical implications are discussed.
Knowledge-Based Repository Scheme for Storing and Retrieving Business Components: A Theoretical Design and an Empirical Analysis

Component-based development (CDB) promises to reduce complexity and cost of software development and maintenance through reuse. For CBD to be successful, a vibrant market for commercial business components is essential. One of the key requirements of an active market for business components is an effective scheme for classifying and describing them at various levels of detail, as well as a corresponding repository for storing and retrieving these components. Such a scheme needs to support various constituents such as business users, managers, and application assemblers. The scheme and repository should help users and managers to select components that match their requirements and aid application assemblers in identifying components most compatible with their deployment environment (such as the platform) and system inputs (such as data types). Drawing from the concepts of group technology and software reuse paradigm, this paper proposes a scheme for classifying and describing business components and the design of a knowledge-based repository for their storage and retrieval. The proposed scheme is implemented in a prototype repository. The effectiveness of the prototype and the underlying classification and coding scheme is assessed empirically through controlled experiments. Results support the assertion that the scheme is effective in enhancing the users’ and analysts’ ability to find the needed business components.
Work disability remains a major problem in rheumatoid arthritis in the 2000s: data from 32 countries in the QUEST-RA Study

INTRODUCTION
Work disability is a major consequence of rheumatoid arthritis (RA), associated not only with traditional disease activity variables, but also more significantly with demographic, functional, occupational, and societal variables. Recent reports suggest that the use of biologic agents offers potential for reduced work disability rates, but the conclusions are based on surrogate disease activity measures derived from studies primarily from Western countries.


METHODS
The Quantitative Standard Monitoring of Patients with RA (QUEST-RA) multinational database of 8,039 patients in 86 sites in 32 countries, 16 with high gross domestic product (GDP) (>24K US dollars (USD) per capita) and 16 low-GDP countries (<11K USD), was analyzed for work and disability status at onset and over the course of RA and clinical status of patients who continued working or had stopped working in high-GDP versus low-GDP countries according to all RA Core Data Set measures. Associations of work disability status with RA Core Data Set variables and indices were analyzed using descriptive statistics and regression analyses.


RESULTS
At the time of first symptoms, 86% of men (range 57%-100% among countries) and 64% (19%-87%) of women <65 years were working. More than one third (37%) of these patients reported subsequent work disability because of RA. Among 1,756 patients whose symptoms had begun during the 2000s, the probabilities of continuing to work were 80% (95% confidence interval (CI) 78%-82%) at 2 years and 68% (95% CI 65%-71%) at 5 years, with similar patterns in high-GDP and low-GDP countries. Patients who continued working versus stopped working had significantly better clinical status for all clinical status measures and patient self-report scores, with similar patterns in high-GDP and low-GDP countries. However, patients who had stopped working in high-GDP countries had better clinical status than patients who continued working in low-GDP countries. The most significant identifier of work disability in all subgroups was Health Assessment Questionnaire (HAQ) functional disability score.


CONCLUSIONS
Work disability rates remain high among people with RA during this millennium. In low-GDP countries, people remain working with high levels of disability and disease activity. Cultural and economic differences between societies affect work disability as an outcome measure for RA.
ANTIMICROBIAL TREATMENT IN DIABETIC WOMEN WITH ASYMPTOMATIC BACTERIURIA

A BSTRACT Background Asymptomatic bacteriuria is common among women with diabetes, and the treatment of such infections has been recommended to prevent complications related to symptomatic urinary tract infection. Methods We enrolled women (>16 years of age) with diabetes, bacteriuria (»10 5 colony-forming units of an organism per milliliter in cultures of two consecutive urine specimens), and no urinary symptoms; 50 were randomly assigned to receive placebo and 55 to receive antimicrobial therapy. For the first six weeks, which included the initial course of treatment, the study was placebo-controlled and double-blind. Subsequently, the women were screened for bacteriuria every three months for up to three years; antimicrobial therapy was provided to women in the antimicrobialtherapy group who had asymptomatic bacteriuria. Results Four weeks after the end of the initial course of therapy, 78 percent of placebo recipients had bacteriuria, as compared with 20 percent of women who received antimicrobial agents (P<0.001). During a mean follow-up of 27 months, 20 of 50 women in the placebo group (40 percent) and 23 of 55 women in the antimicrobial-therapy group (42 percent) had at least one episode of symptomatic urinary tract infection. The time to a first symptomatic episode was similar in the placebo group and the antimicrobial-therapy group (P=0.67 by the log-rank test), as were the (±SD) rates of any symptomatic urinary tract infection (1.10±0.17 and 0.93±0.14 per 1000 days of follow-up, respectively; relative risk, 1.19; 95 percent confidence interval, 0.28 to 1.81), pyelonephritis (0.28±0.08 and 0.13±0.05 per 1000 days of follow-up; relative risk, 2.13; 95 percent confidence interval, 0.81 to 5.62), and hospitalization for urinary tract infection (0.10±0.36 and 0.06±0.22 per 1000 days of follow-up; relative risk, 1.93; 95 percent confidence interval, 0.47 to 7.89). The women in the antimicrobial-therapy group had almost five times as many days of antibiotic use for urinary tract infection as did the women in the placebo group (158.2±1.7 vs. 33.7±0.91 per 1000 days of follow-up; relative risk, 0.21; 95 percent confidence interval, 0.20 to 0.22). Conclusions Treatment of asymptomatic bacteriuria in women with diabetes does not appear to reduce complications. Diabetes itself should not be an indication for screening for or treatment of asymptomatic bacteriuria. (N Engl J Med 2002;347:1576-83).
Long-term risk of venous thrombosis after stopping anticoagulants for a first unprovoked event: A multi-national cohort.

BACKGROUND
Choosing short-term (3-6 months) or indefinite anticoagulation after a first unprovoked venous thromboembolic event (VTE) is a common and difficult clinical decision. The long-term absolute risk of recurrent VTE after a first unprovoked VTE, in all patients and sub-groups, is not well established, hindering decision making.


METHODS
We conducted a multi-center multi-national prospective cohort study in first unprovoked VTE patients to establish the long-term risk of recurrent VTE after short-term anticoagulation in first unprovoked VTE patients (and sub-groups).We followed patients for symptomatic suspected VTE off of OAT. Suspected recurrent VTE was investigated with reference to baseline imaging and then independently and blindly adjudicated.


FINDINGS
We recruited 663 participants between October, 2001 and March 2006 with the last follow-up in April 2014. During a mean 5.0 years of follow-up, 165/663 suspected VTE (in 408 patients) were adjudicated as recurrent VTE resulting in an annualized risk of recurrent VTE of 5.0% (95% CI: 4.2-5.8%) with a cumulative risk of 29.6% at 8 years. Men had a 7.6% (95% CI: 6.3-9.2%) annual risk of recurrent VTE. High risk women (2 or more HERDOO2 points; see text) had an annual risk of recurrent VTE of 5.9% (95% CI: 4.2-8.1%). Low risk women (1 or 0 HERDOO2 points) had 1.1% (95% CI: 0.6-2.0%) annual risk of recurrent VTE with a cumulative risk of 8.7% at 8 years.


INTERPRETATION
Men and high risk women with unprovoked VTE should be considered for long-term anticoagulant therapy given a high risk of recurrent VTE after long-term follow-up. Women with a low HERDOO2 score may be able to safely discontinue anticoagulants.


FUNDING
This study was funded by the Canadian Institutes of Health Research (Grant # MOP 64319) and Heart and Stroke Foundation of Ontario (Grant # NA 6771). Registered at www.clinicaltrials.gov identifier: NCT00261014.
DisIRer: Converting a retargetable compiler into a multiplatform binary translator

This article proposes an alternative yet effective way of constructing a multiplatform binary translator, by converting a retargetable compiler into a binary translator. The rationale is that a retargetable compiler usually parses source programs into an Intermediate Representation (IR), and then translates IR into object code of different targets after performing analysis and optimizations. Specifically, the mechanism of code generation for multiple platforms from IR is already in place, and the missing link of building a multiplatform binary translator is a tool to transform binary programs back into IR. In order to fill in this missing link, this article presents a tool, called the disIRer. Just as a translator from machine language to assembly language is called a disassembler, a tool that translates executable binary programs to IR is called here a disIRer. The unique feature of this approach is that the retargetability of the binary translator is inherited directly from the retargetable compiler. A prototype multiplatform binary translator has been implemented upon GCC (the GNU Compiler Collection). DisIRer first converts binary programs back into GCC IR (Intermediate Representation), and afterward the GCC backend translates the IR to target binary programs of specified platforms. Experimental results show that x86 binary programs can be translated by this technique into ARM and Alpha binaries with reasonable code density and quality.
Identification of coronary plaque sub-types using virtual histology intravascular ultrasound is affected by inter-observer variability and differences in plaque definitions.

BACKGROUND
Recent studies show that virtual histology intravascular ultrasound (VH-IVUS) can identify plaques at high risk of rupture, such as thin-capped fibroatheromata, raising the possibility of immediate targeted intervention. However, plaque classification entails border recognition and subjective assessment of plaque architecture, introducing inter-observer variability without confirmation by core-labs. Furthermore, the accuracy of local versus core-laboratory VH-IVUS plaque classification and effects of different plaque definitions have not been examined.


METHODS AND RESULTS
Local observers classified 100 VH-IVUS-defined coronary plaques to determine single center inter-observer variability; multi-center variability was determined by comparison with VH-IVUS core-laboratory analysis, and compared with gray-scale IVUS. Frequency of plaque types using different published plaque definitions also was determined. Single-center VH-IVUS inter-observer agreement was strong (kappa=0.86), but lower for thin-capped fibroatheromatas (k=0.59) because of observer judgments on presence and location of confluent necrotic core. Multi-center inter-observer agreement for plaque classification was lower again (k=0.71), particularly for thin-capped fibroatheromatas (k=0.56). Different plaque definitions further reduced VH-IVUS-defined thin-capped fibroatheromata numbers by 44%. The diagnostic accuracy of gray-scale IVUS to identify thin-capped fibroatheromata was poor for both observers (21 and 29% correct), with low inter-observer agreement (k=0.14).


CONCLUSIONS
VH-IVUS plaque classification, and particularly VH-IVUS-defined thin-capped fibroatheromata identification, varies significantly between local observers, and particularly in comparison with core-laboratory analysis. Differences in VH-IVUS plaque definitions introduce further variability between studies. These factors reduce the use of VH-IVUS plaque classification to guide intervention in a "live" clinical setting, and also affect comparison of diagnostic accuracy and natural history of plaques between studies.
The Rademacher Complexity of Linear Transformation Classes

Bounds are given for the empirical and expected Rademacher complexity of classes of linear transformations from a Hilbert space H to a nite dimensional space. The results imply generalization guarantees for graph regularization and multi-task subspace learning. 1 Introduction Rademacher averages have been introduced to learning theory as an e¢ cient complexity measure for function classes, motivated by tight, sample or distribution dependent generalization bounds ([10], [2]). Both the denition of Rademacher complexity and the generalization bounds extend easily from realvalued function classes to function classes with values in R, as they are relevant to multi-task learning ([1], [12]). There has been an increasing interest in multi-task learning which has shown to be very e¤ective in experiments ([7], [1]), and there have been some general studies of its generalisation performance ([4], [5]). For a large collection of tasks there are usually more data available than for a single task and these data may be put to a coherent use by some constraint of relatedness. A practically interesting case is linear multi-task learning, extending linear large margin classiers to vector valued large-margin classiers. Di¤erent types of constraints have been proposed: Evgeniou et al ([8], [9]) propose graph regularization, where the vectors dening the classiers of related tasks have to be near each other. They also show that their scheme can be implemented in the framework of kernel machines. Ando and Zhang [1] on the other hand require the classiers to be members of a common low dimensional subspace. They also give generalization bounds using Rademacher complexity, but these bounds increase with the dimension of the input space. This paper gives dimension free bounds which apply to both approaches. 1.1 Multi-task generalization and Rademacher complexity Suppose we have m classication tasks, represented by m independent random variables X ; Y l taking values in X f 1; 1g, where X l models the random
Preliminary efficacy and safety of oral suspension SH, combination of five chinese medicinal herbs, in people living with HIV/AIDS ; the phase I/II study.

OBJECTIVE
To evaluate the preliminary efficacy and safety of the mixture of drug extracts from 5 Chinese medicinal herbs (SH), in the treatment of Human Immunodeficiency Virus (HIV) infection among people living with HIV/AIDS (PLWHA).


DESIGN
Open-label study.


SETTING
Sanpatong Hospital, Chiang Mai, Thailand.


SUBJECTS
HIV-1 infected adults with a CD4 cell count of more than 200 cell/mm3 and HIV-1 RNA > 20,000 copies/ml.


MATERIAL AND METHOD
Patients received an oral suspension of SH, a combination of 5 Chinese medicinal herbs namely Glycyrrhiza glaba L., Artemisia capillaris Thumb., Morus alba L., Astragalus membranaceus(Fisch.) Bge., Carthamus tinctorius L., 5 g or 30 ml, in 3 divided doses after meals, plus sulfamethozaxole/ trimethoprim, 400/80 mg tablet, once daily after breakfast for 12 weeks. During the treatment and the follow up period, the absolute CD4 cell count and the plasma HIV-1 RNA were monitored. Adverse events were observed.


RESULTS
Of the 28 enrolled patients, the number of positive response patients with reduction of plasma HIV-1 RNA more than 0.5 log during the treatment and follow up period were 4-10 (14.2-35.7%) while the number of negative response patients who had plasma HIV-1 RNA rising at least 0.5 log were 2-4 (0-14.2%). The means viral load at week 0 (baseline), 12 and 20 were 4.94, 4.83 and 4.76 log copies/ml, which were slightly declined Whilst, the mean absolute CD4 cell count of week 0 (baseline), 4, 8, 12, and 20 fluctuated within the baseline, range of 382.1, 404.2, 359.4, 404.1, 360.2 cell/mm3, respectively. All subjects had good compliance without any serious adverse events.


CONCLUSION
Under the condition used, SH drug therapy is safe. Satisfactory positive response, by decreased viral load of more than 0.5 log, was found in 14%-35% of HIV-positive patients. However, the immunologic response, an increase of CD4 cell count was not clearly demonstrated. The clinical benefit of SH needs more thorough scientific support before being prescribed as adjunctive therapy for treating PLWHA.