LLukas22/scidocs huggingface dataset:
Electrical stimulation site influences the spatial distribution of motor units recruited in tibialis anterior

OBJECTIVE
To compare the spatial distribution of motor units recruited in tibialis anterior (TA) when electrical stimulation is applied over the TA muscle belly versus the common peroneal nerve trunk.


METHODS
Electromyography (EMG) was recorded from the surface and from fine wires in superficial and deep regions of TA. Separate M-wave recruitment curves were constructed for muscle belly and nerve trunk stimulation.


RESULTS
During muscle belly stimulation, significantly more current was required to generate M-waves that were 5% of the maximal M-wave (M max; M5%max), 50% M max (M 50%max) and 95% M max (M 95%max) at the deep versus the superficial recording site. In contrast, during nerve trunk stimulation, there were no differences in the current required to reach M5%max, M 50%max or M 95%max between deep and superficial recording sites. Surface EMG reflected activity in both superficial and deep muscle regions.


CONCLUSIONS
Stimulation over the muscle belly recruited motor units from superficial to deep with increasing stimulation amplitude. Stimulation over the nerve trunk recruited superficial and deep motor units equally, regardless of stimulation amplitude.


SIGNIFICANCE
These results support the idea that where electrical stimulation is applied markedly affects how contractions are produced and have implications for the interpretation of surface EMG data.
Web Spam Taxonomy

Web spamming refers to actions intended to mislead search engines into ranking some pages higher than they deserve. Recently, the amount of web spam has increased dramatically, leading to a degradation of search results. This paper presents a comprehensive taxonomy of current spamming techniques, which we believe can help in developing appropriate countermeasures.
Querying and mining data streams: you only get one look a tutorial

1. MOTIVATION AND SUMMARY Traditional Database Management Systems (DBMS) software is built on the concept of persistent data sets, that are stored reliably in stable storage and queried/updated several times throughout their lifetime. For several emerging application domains, however, data arrives and needs to be processed on a continuous ( ) basis, without the benefit of several passes over a static, persistent data image. Such continuous data streams arise naturally, for example, in the network installations of large Telecom and Internet service providers where detailed usage information (Call-Detail-Records (CDRs), SNMP/RMON packet-flow data, etc.) from different parts of the underlying network needs to be continuously collected and analyzed for interesting trends. Other applications that generate rapid, continuous and large volumes of stream data include transactions in retail chains, ATM and credit card operations in banks, financial tickers, Web server log records, etc. In most such applications, the data stream is actually accumulated and archived in the DBMS of a (perhaps, off-site) data warehouse, often making access to the archived data prohibitively expensive. Further, the ability to make decisions and infer interesting patterns on-line (i.e., as the data stream arrives) is crucial for several mission-critical tasks that can have significant dollar value for a large corporation (e.g., telecom fraud detection). As a result, recent years have witnessed an increasing interest in designing data-processing algorithms that work over continuous data streams, i.e., algorithms that provide results to user queries while looking at the relevant data items only once and in a fixed order (determined by the stream-arrival pattern). Two key parameters for query processing over continuous datastreams are (1) the amount of memory made available to the online algorithm, and (2) the per-item processing time required by the query processor. The former constitutes an important constraint on the design of stream processing algorithms, since in a typical streaming environment, only limited memory resources are available to the query-processing algorithms. In these situations, we need algorithms that can summarize the data stream(s) involved in a concise, but reasonably accurate, synopsis that can be stored in the allotted (small) amount of memory and can be used to provide approximate answers to user queries along with some reasonable guarantees on the quality of the approximation. Such approx-
Comparative gender analysis of the efficacy and safety of atazanavir/ritonavir and lopinavir/ritonavir at 96 weeks in the CASTLE study

OBJECTIVES
To examine whether the overall results of the CASTLE study pertain to both genders, we analysed the efficacy and safety of atazanavir/ritonavir and lopinavir/ritonavir in 277 female and 606 male patients in the open-label, multinational trial over 96 weeks. The trial is registered with ClinicalTrials.gov, number NCT00272779.


METHODS
Treatment-naive patients aged ≥ 18 years with HIV-1 RNA ≥ 5000 copies/mL were randomized to receive either atazanavir/ritonavir 300/100 mg once daily or lopinavir/ritonavir 400/100 mg twice daily, with fixed-dose tenofovir/emtricitabine 300/200 mg once daily.


RESULTS
At week 96, confirmed virological response rates (HIV RNA <50 copies/mL; intent-to-treat analysis) were higher in women and men receiving atazanavir/ritonavir than those receiving lopinavir/ritonavir and lower in women than men in both treatment arms (67% of women and 77% of men on atazanavir/ritonavir and 63% of women and 71% of men on lopinavir/ritonavir). These differences were not observed in the on-treatment analysis. Mean change in CD4 cell count from baseline to week 96 was 265 cells/mm(3) for women and 269 cells/mm(3) for men on atazanavir/ritonavir and 298 cells/mm(3) for women and 286 cells/mm(3) for men on lopinavir/ritonavir. Discontinuation rates were higher in women than men in each treatment arm (22% of women and 15% of men on atazanavir/ritonavir and 29% of women and 18% of men on lopinavir/ritonavir). In women and men, grade 2-4 nausea and diarrhoea were more frequent in the lopinavir/ritonavir group; jaundice and hyperbilirubinaemia occurred more frequently in the atazanavir/ritonavir group.


CONCLUSIONS
Once-daily atazanavir/ritonavir is an effective and well-tolerated therapeutic option for women and men with HIV-1 infection. The sex-based differences in response may be due to higher discontinuation rates in women.
STATISTICALLY STABLE ESTIMATES OF VARIANCE IN RADIO-ASTRONOMY OBSERVATIONS AS TOOLS FOR RADIO-FREQUENCY INTERFERENCE MITIGATION

A selection of statistically stable (robust) algorithms for data variance calculating has been made. Their properties have been analyzed via computer simulation. These algorithms would be useful if adopted in radio astronomy observations in the presence of strong sporadic radio frequency interference (RFI). Several observational results have been presented here to demonstrate the effectiveness of these algorithms in RFI mitigation. Subject headings: methods: miscellaneous — methods: statistical
Exploring the importance of citizen participation and involvement in e-government projects : Practice , incentives , and organization

Purpose – The purpose of this research is to investigate if, and in that case, how and what the egovernment field can learn from user participation concepts and theories in general IS research. We aim to contribute with further understanding of the importance of citizen participation and involvement within the e-government research body of knowledge and when developing public eservices in practice. Design/Methodology/Approach – The analysis in the article is made from a comparative, qualitative case study of two e-government projects. Three analysis themes are induced from the literature review; practice of participation, incentives for participation, and organization of participation. These themes are guiding the comparative analysis of our data with a concurrent openness to interpretations from the field. Findings – The main results in this article are that the e-government field can get inspiration and learn from methods and approaches in traditional IS projects concerning user participation, but in egovernment we also need methods to handle the challenges that arise when designing public e-services for large, heterogeneous user groups. Citizen engagement cannot be seen as a separate challenge in egovernment, but rather as an integrated part of the process of organizing, managing, and performing egovernment projects. Our analysis themes of participation generated from literature; practice, incentives and organization can be used in order to highlight, analyze, and discuss main issues regarding the challenges of citizen participation within e-government. This is an important implication based on our study that contributes both to theory on and practice of e-government. Practical implications – Lessons to learn from this study concern that many e-government projects have a public e-service as one outcome and an internal e-administration system as another outcome. A dominating internal, agency perspective in such projects might imply that citizens as the user group of the e-service are only seen as passive receivers of the outcome – not as active participants in the development. By applying the analysis themes, proposed in this article, citizens as active participants can be thoroughly discussed when initiating (or evaluating) an e-government project. Originality/value – This article addresses challenges regarding citizen participation in e-government development projects. User participation is well-researched within the IS discipline, but the egovernment setting implies new challenges, that are not explored enough.
CHAUFFEUR Assistant: a driver assistance system for commercial vehicles based on fusion of advanced ACC and lane keeping

This paper presents the integrated approach for environment perception and vehicle control developed for the CHAUFFEUR Assistant application. Using a combination of radar and video sensor, the sensor fusion approach provides the vehicle controllers with valuable data about preceding vehicles and about the lane. These controllers guide the truck to stay in the lane and keep a short but still safe distance to the preceding vehicle.
Adapting a parallel sparse direct solver to architectures with clusters of SMPs

We consider the direct solution of general sparse linear systems baseds on a multifrontal method. The approach combines partial static scheduling of the task dependency graph during the symbolic factorization and distributed dynamic scheduling during the numerical factorization to balance the work among the processes of a distributed memory computer. We show that to address clusters of Symmetric Multi-Processor (SMP) architectures, and more generally non-uniform memory access multiprocessors, our algorithms for both the static and the dynamic scheduling need to be revisited to take account of the non-uniform cost of communication. The performance analysis on an IBM SP3 with 16 processors per SMP node and up to 128 processors shows that we can significantly reduce both the amount of inter-node communication and the solution time. 2003 Elsevier Ltd. All rights reserved.
Accessing WordNet from Prolog

WordNet is a lexical reference system, developed by the university of Princeton. This paper gives a detailed documentation of the Prolog database of WordNet and predicates to interface it. 1
AN INTRODUCTION TO DYNAMICAL BILLIARDS

Some billiard tables in R2 contain crucial references to dynamical systems but can be analyzed with Euclidean geometry. In this expository paper, we will analyze billiard trajectories in circles, circular rings, and ellipses as well as relate their charactersitics to ergodic theory and dynamical systems.
The role of ''dark personalities" (narcissism, Machiavellianism, psychopathy), Big Five personality factors, and ideology in explaining prejudice

The so-called Dark Triad (narcissism, Machiavellianism, psychopathy) represent correlated subclinical personality traits capturing ‘‘dark personalities”. How might darker personalities contribute to prejudice? In the present study (n = 197), these dark personality variables correlated positively with outgroup threat perceptions and anti-immigrant prejudice. A proposed two-stage structural equation model, assuming indirect personality effects (Dark Personality, Big Five) on prejudice through ideology and group threat perceptions, fit the data well. Specifically, a latent Dark Personality factor predicted social dominance orientation, whereas (low) Openness to Experience predicted right-wing authoritarianism; these ideological variables each predicted prejudice directly and indirectly through heightened intergroup threat. The authors recommend that personality models of prejudice incorporate both normal-range and subclinical personality predictors, in addition to ideological and social psychological mediators. 2009 Elsevier Inc. All rights reserved.
Efficacy and safety of inhaled insulin (Exubera) compared with subcutaneous insulin therapy in patients with type 1 diabetes: results of a 6-month, randomized, comparative trial.

OBJECTIVE
The aim of this study was to determine whether premeal pulmonary delivery of rapid-acting, dry-powder insulin (Exubera) plus Ultralente could provide glycemic control comparable to a conventional insulin regimen in type 1 diabetes.


RESEARCH DESIGN AND METHODS
Three hundred thirty-five subjects were randomly assigned to receive either premeal inhaled insulin plus bedtime Ultralente or two to three injections of regular and NPH insulin for 24 weeks. The primary end point was a change in HbA(1c).


RESULTS
Mean decreases in HbA(1c) values were comparable for inhaled (8.1-7.9%) and conventional groups (8.1-7.7%) (adjusted treatment group difference 0.16% [95% CI -0.01 to 0.32]). There were greater reductions for inhaled versus conventional regimen in fasting and postprandial plasma glucose (adjusted mean change differences -25.17 and -30.28 mg/dl, respectively [95% CI -43.39 to -6.95 and -54.58 to -5.97, respectively]). Hypoglycemia (events/subject month) was lower for the inhaled (8.6) versus the conventional (9.0) group (risk ratio, 0.96 [95% CI 0.93-0.99]). In subjects receiving inhaled insulin, increased insulin antibody levels were observed, but there were no associated clinical or laboratory changes. Adverse events were comparable between groups. Mild to moderate cough was more frequent in the inhaled insulin group (27 vs. 5%) but decreased during the treatment. Pulmonary function tests were not different between the groups except for a greater decrease in carbon monoxide diffusing capacity in the inhaled insulin group. Treatment satisfaction was greater in the inhaled than in the conventional group.


CONCLUSIONS
Inhaled insulin is effective, well tolerated, and well accepted in patients with type 1 diabetes and provides glycemic control comparable to that with a conventional insulin regimen.
A Modified ABCDE Model of Flowering in Orchids Based on Gene Expression Profiling Studies of the Moth Orchid Phalaenopsis aphrodite

Previously we developed genomic resources for orchids, including transcriptomic analyses using next-generation sequencing techniques and construction of a web-based orchid genomic database. Here, we report a modified molecular model of flower development in the Orchidaceae based on functional analysis of gene expression profiles in Phalaenopsis aphrodite (a moth orchid) that revealed novel roles for the transcription factors involved in floral organ pattern formation. Phalaenopsis orchid floral organ-specific genes were identified by microarray analysis. Several critical transcription factors including AP3, PI, AP1 and AGL6, displayed distinct spatial distribution patterns. Phylogenetic analysis of orchid MADS box genes was conducted to infer the evolutionary relationship among floral organ-specific genes. The results suggest that gene duplication MADS box genes in orchid may have resulted in their gaining novel functions during evolution. Based on these analyses, a modified model of orchid flowering was proposed. Comparison of the expression profiles of flowers of a peloric mutant and wild-type Phalaenopsis orchid further identified genes associated with lip morphology and peloric effects. Large scale investigation of gene expression profiles revealed that homeotic genes from the ABCDE model of flower development classes A and B in the Phalaenopsis orchid have novel functions due to evolutionary diversification, and display differential expression patterns.
An English Perspective on the German Contribution to Engineering Design

Germany has an international reputation for the high quality of its engineering products. This is due in part to placing great emphasis on engineering design and according high status to engineering designers.
Control Strategies for Islanded Microgrid Using Enhanced Hierarchical Control Structure With Multiple Current-Loop Damping Schemes

In this paper, the modeling, controller design, and stability analysis of the islanded microgrid (MG) using enhanced hierarchical control structure with multiple current loop damping schemes is proposed. The islanded MG consists of the parallel-connected voltage source inverters using inductor-capacitor-inductor (LCL) output filters, and the proposed control structure includes the primary control with additional phase-shift loop, the secondary control for voltage amplitude and frequency restoration, the virtual impedance loops which contain virtual positive- and negative-sequence impedance loops at fundamental frequency and virtual variable harmonic impedance loop at harmonic frequencies, and the inner voltage and current loop controllers. A small-signal model for the primary and secondary controls with additional phase-shift loop is presented, which shows an over-damped feature from eigenvalue analysis of the state matrix. The moving average filter-based sequence decomposition method is proposed to extract the fundamental positive and negative sequences and harmonic components. The multiple inner current loop damping scheme is presented, including the virtual positive, virtual negative, and variable harmonic sequence impedance loops for reactive and harmonic power sharing purposes, and the proposed active damping scheme using capacitor current feedback loop of the LCL filter, which shows enhanced damping characteristics and improved inner-loop stability. Finally, the experimental results are provided to validate the feasibility of the proposed approach.
MTRX1011A, a humanized anti-CD4 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: a Phase I randomized, double-blind, placebo-controlled study incorporating pharmacodynamic biomarker assessments

INTRODUCTION
The purpose of this study was to evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of the humanized anti-CD4 monoclonal antibody MTRX1011A in a randomized, double-blind placebo-controlled Phase 1 study in patients with rheumatoid arthritis (RA).


METHODS
In the single ascending dose (SAD) portion of the study, patients received single doses of a placebo or MTRX1011A at 0.3, 1.0, 3.5 and 7.0 mg/kg intravenously (i.v.) or 1.0 and 3.5 mg/kg subcutaneously (s.c.), followed by five weeks of evaluation. In the multi-dose (MD) portion of the study, placebo or MTRX1011A was administered weekly for eight doses at 1.5 or 3.5 mg/kg s.c., or 5 mg/kg i.v., followed by eight weeks of evaluation.


RESULTS
MTRX1011A was well tolerated in the SAD phase up to 7 mg/kg i.v. and in the MD phase up to 1.5 mg/kg s.c.. At weekly doses of 3.5 mg/kg s.c. and 5 mg/kg i.v., a moderate pruritic papular rash was observed in some MTRX1011A-treated patients, which was considered a dose-limiting toxicity for this clinical indication. No serious adverse events occurred in any cohort. Reduction in disease activity was modest. PD assessments demonstrated that MTRX1011A induced a dose-dependent down-modulation of CD4 expression on peripheral blood CD4 T cells, CD4 receptor occupancy, increases in serum sCD4-MTRX1011A complexes and up-regulation of CD69 on T cells, but was non-depleting.


CONCLUSIONS
The maximum tolerated dose of MTRX1011A was 1.5 mg/kg SC administered weekly. At this dose MTRX1011A did not achieve maximum PD activity expected to be required for reduction in disease activity.
An energy efficient pedestrian aware Smart Street Lighting system

Purpose – Conventional street lighting systems in areas with a low frequency of passersby are online most of the night without purpose. The consequence is that a large amount of power is wasted meaninglessly. With the broad availability of flexible-lighting technology like light-emitting diode lamps and everywhere available wireless internet connection, fast reacting, reliably operating, and power-conserving street lighting systems become reality. The purpose of this work is to describe the Smart Street Lighting (SSL) system, a first approach to accomplish the demand for flexible public lighting systems. Design/methodology/approach – This work presents the SSL system, a framework developed for a dynamic switching of street lamps based on pedestrians’ locations and desired safety (or “fear”) zones. In the developed system prototype, each pedestrian is localized via his/her smartphone, periodically sending location and configuration information to the SSL server. For street lamp control, each and every lamppost is equipped with a ZigBee-based radio device, receiving control information from the SSL server via multi-hop routing. Findings – This research paper confirms that the application of the proposed SSL system has great potential to revolutionize street lighting, particularly in suburban areas with low-pedestrian frequency. More important, the broad utilization of SSL can easily help to overcome the regulatory requirement for CO2 emission reduction by switching off lampposts whenever they are not required. Research limitations/implications – The paper discusses in detail the implementation of SSL, and presents results of its application on a small scale. Experiments have shown that objects like trees can interrupt wireless communication between lampposts and that inaccuracy of global positioning system position detection can lead to unexpected lighting effects. Originality/value – This paper introduces the novel SSL framework, a system for fast, reliable, and energy efficient street lamp switching based on a pedestrian’s location and personal desires of safety. Both safety zone definition and position estimation in this novel approach is accomplished using standard smartphone capabilities. Suggestions for overcoming these issues are discussed in the last part of the paper.