LLukas22/scidocs huggingface dataset:
Reducing energy demand: A review of issues, challenges and approaches

Most commentators expect improved energy efficiency and reduced energy demand to provide the dominant contribution to tackling global climate change. But at the global level, the correlation between increased wealth and increased energy consumption is very strong and the impact of policies to reduce energy demand is both limited and contested. Different academic disciplines approach energy demand reduction in different ways: emphasising some mechanisms and neglecting others, being more or less optimistic about the potential for reducing energy demand and providing insights that are more or less useful for policymakers. This article provides an overview of the main issues and challenges associated with energy demand reduction, summarises how this challenge is ‘framed’ by key academic disciplines, indicates how these can provide complementary insights for policymakers and argues that a ‘sociotechnical’ perspective can provide a deeper understanding of the nature of this challenge and the processes through which it can be achieved. The article integrates ideas from the natural sciences, economics, psychology, innovation studies and sociology but does not give equal weight to each. It argues that reducing energy demand will prove more difficult than is commonly assumed and current approaches will be insufficient to deliver the transformation required. & 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
MiR-26b suppresses tumor cell proliferation, migration and invasion by directly targeting COX-2 in lung cancer.

OBJECTIVE
Lung cancer, including non-small cell lung cancer (NSCLC), is the leading cause of cancer-related mortality worldwide. Despite recent advances in clinical and experimental oncology, the prognosis of patients with NSCLC still remains poor and the average survival time of patients suffer from lung cancer is low. Therefore, the potential mechanism accounting for the tumorigenesis of NSCLC is still needed to be explored.


MATERIALS AND METHODS
A lentiviral vector over-expressing miR-26b in A549 lung cancer cells was constructed. Cell proliferation, migration and invasion analysis were measured by cell counting kit (MTT), would healing assay and Transwell assay. Direct target of miR-26b in A549 cells was examined using bioinformatics and Luciferase assay.


RESULTS
Herein, we found that over-expression of miR-26b significantly inhibited the proliferation, migration and invasion of A549 lung cancer cell in vitro and suppressed the growth of established tumors in vivo. By using bioinformatics, we found that COX-2 (Cyclooxygenase-2) is one of the potential targets of miR-26b. Moreover, miR-26b was found to negatively regulate COX-2 protein level by directly targeting its 3'UTR. In addition, depletion of endogenous COX-2 by the specific siRNA could mimic the function of miR-26b overexpression.


CONCLUSIONS
Taken together, our results demonstrate that miR-26b could suppress lung cancer cells proliferation, migration and invasion by directly negative regulation of COX-2. MiR-26b could serve as a novel potential marker for NSCLC therapy.
On the Lorentz-invariant time-energy uncertainty relation for a relativistic photon

The time-energy uncertainty relation is discussed for a relativistic massless particle. The Lorentz-invariant uncertainty relation is obtained between the root-mean-square energy deviation and the scatter of registration time. The interconnection between this uncertainty relation and its classical analogue is established.
Study on Environmental Impact Assessment of River Comprehensive Treatment Engineering in Urban Areas

By taking comprehensive treatment engineering of Zhupaichong river as an example,the impact assessment of dust,noise,solid waste,soil and water loss and sludge dredge from these construction projects are discussed.These impacts on river ecological system in construction periods and running periods are presented.Ssome applicable and feasible countermeasures are pointed out.
Cake cutting: not just child's play

How to fairly allocate divisible resources, and why computer scientists should take notice.
CONTAINER PORT PRODUCTION EFFICIENCY: A Comparative Study of DEA and FDH Approaches

Container terminal production is both an important and complicated element in the contemporary global economy. Amongst other methods, the efficiency of container port or terminal production can potentially be analysed by Data Envelopment Analysis (DEA) or by the Free Disposal Hull (FDH) Model. This paper aims to evaluate the efficiency of the world’s most important container ports and terminals using the two alternative techniques. The results show that the available mathematical programming methodologies lead to different conclusions. It is also concluded that the availability of panel data, rather than cross-sectional data would greatly improve the validity of the efficiency estimates derived from all the mathematical programming techniques applied.
Improved Guarantees for Vertex Sparsification in Planar Graphs

Graph Sparsification aims at compressing large graphs into smaller ones while (approximately) preserving important characteristics of the input graph. In this work we study Vertex Sparsifiers, i.e., sparsifiers whose goal is to reduce the number of vertices. Given a weighted graph G = (V,E), and a terminal setK with |K| = k, a quality-q vertex cut sparsifier ofG is a graphH withK ⊂ VH that preserves the value of minimum cuts separating any bipartition of K, up to a factor of q. We show that planar graphs with all the k terminals lying on the same face admit quality-1 vertex cut sparsifier of size O(k2) that are also planar. Our result extends to vertex flow and distance sparsifiers. It improves the previous best known bound of O(k222k) for cut and flow sparsifiers by an exponential factor, and matches an Ω(k2) lower-bound for this class of graphs. We also study vertex reachability sparsifiers for directed graphs. Given a digraph G = (V,E) and a terminal set K, a vertex reachability sparsifier of G is a digraph H = (VH , EH), K ⊂ VH that preserves all reachability information among terminal pairs. We introduce the notion of reachability-preserving minors, i.e., we require H to be a minor of G. Among others, for general planar digraphs, we construct reachability-preserving minors of size O(k2 log2 k). We complement our upper-bound by showing that there exists an infinite family of acyclic planar digraphs such that any reachability-preserving minor must have Ω(k2) vertices. 1998 ACM Subject Classification G.2.2 Graph Theory, F.2.2 Nonnumerical Algorithms and Problems
Six years of systematic literature reviews in software engineering: An updated tertiary study

Context: Since the introduction of evidence-based software engineering in 2004, systematic literature review (SLR) has been increasingly used as a method for conducting secondary studies in software engineering. Two tertiary studies, published in 2009 and 2010, identified and analysed 54 SLRs published in journals and conferences in the period between 1st January 2004 and 30th June 2008. Objective: In this article, our goal was to extend and update the two previous tertiary studies to cover the period between 1st July 2008 and 31st December 2009. We analysed the quality, coverage of software engineering topics, and potential impact of published SLRs for education and practice. Method: We performed automatic and manual searches for SLRs published in journals and conference proceedings, analysed the relevant studies, and compared and integrated our findings with the two previous tertiary studies. Results: We found 67 new SLRs addressing 24 software engineering topics. Among these studies, 15 were considered relevant to the undergraduate educational curriculum, and 40 appeared of possible interest to practitioners. We found that the number of SLRs in software engineering is increasing, the overall quality of the studies is improving, and the number of researchers and research organisations worldwide that are conducting SLRs is also increasing and spreading. Conclusion: Our findings suggest that the software engineering research community is starting to adopt SLRs consistently as a research method. However, the majority of the SLRs did not evaluate the quality of primary studies and fail to provide guidelines for practitioners, thus decreasing their potential impact on software engineering practice. 2011 Elsevier B.V. All rights reserved.
Safety, efficacy, and pharmacokinetics of adefovir dipivoxil in children and adolescents (age 2 to <18 years) with chronic hepatitis B.

UNLABELLED
This study investigated the efficacy, safety, and pharmacokinetics of adefovir dipivoxil (ADV) in children and adolescents with chronic hepatitis B (CHB). A total of 173 treatment-naive and treatment-experienced children with hepatitis B e antigen (HBeAg)+ CHB were randomized to ADV or placebo. Randomization was stratified by age (2 to <7 years; >7 to <12 years; >12 to <18 years) and prior treatment. Significantly more ADV-treated subjects aged 12 to <18 years achieved the primary efficacy endpoint (serum hepatitis B virus [HBV] DNA <1,000 copies/mL and normal alanine aminotransferase) compared to placebo-treated subjects (23% versus 0%; P = 0.007). In the younger groups, differences between ADV and placebo at the end of blinded treatment were not statistically significant. More ADV-treated subjects had HBeAg seroconversion: 18 of 113 (15.9%) versus three of 57 (5.3%) (but P = 0.051), and more met the combined endpoint of HBeAg seroconversion, HBV DNA <1,000 copies/mL and normal alanine aminotransferase (12/113 versus 0/57; P = 0.009). No subject developed an ADV-associated mutation that has been linked to HBV DNA rebound (that is, mutations rtN236T or rtA181V). ADV plasma concentrations were comparable across groups and within the target range. ADV treatment was well tolerated; no new safety issues were identified. Treatment-related adverse events were reported for 12% of ADV-treated and 10% of placebo-treated subjects. After 48 weeks of ADV treatment, antiviral efficacy in subjects ages 12 to <18 years with HBeAg+ CHB was similar to that observed in a study in adult treatment-naive subjects with HBeAg+ CHB. ADV was not different from placebo in subjects aged 2 to 11 years despite adequate plasma ADV exposure in all three age groups.


CONCLUSION
ADV showed significant antiviral efficacy in subjects aged 12 to 17 years with HBeAg+ CHB, but was not different from placebo in subjects aged 2 to 11 years.
Comparing connectomes across subjects and populations at different scales

Brain connectivity can be represented by a network that enables the comparison of the different patterns of structural and functional connectivity among individuals. In the literature, two levels of statistical analysis have been considered in comparing brain connectivity across groups and subjects: 1) the global comparison where a single measure that summarizes the information of each brain is used in a statistical test; 2) the local analysis where a single test is performed either for each node/connection which implies a multiplicity correction, or for each group of nodes/connections where each subset is summarized by one single test in order to reduce the number of tests to avoid a penalizing multiplicity correction. We comment on the different levels of analysis and present some methods that have been proposed at each scale. We highlight as well the possible factors that could influence the statistical results and the questions that have to be addressed in such an analysis.
Lateral thinking about power devices (LDMOS)

BiCMOS Power technology LDMOS are reviewed with respect to category and structure definition and briefly as to how the structures relate to figure of merit performance. Stepped gate oxide devices are introduced making use of popular dual gate technologies and exhibit improved R/sub sp/ vs. BV performance of up to 30% at low V/sub gs/ without sacrifice of BV. Production use of thick copper plated bussing up to 25 /spl mu/m thick with R/sub sh/=0.8 m/spl Omega//sq is revealed for power, enabling up to 40% efficiency improvement on LDMOS power transistors.
Effects of plant growth regulators and elicitors on production of secondary metabolites in shoot cultures of Hypericum hirsutum and Hypericum maculatum

We investigated the effects of plant growth regulators [6-benzyladenine (BA), kinetin (Kin), 6-γ,γ-dimethylallylaminopurine (2iP), thidiazuron (TDZ) and α-naphthaleneacetic acid (NAA)], modified Murashige and Skoog (MS) medium containing 10 mM NH4 + and 5 mM NO3 − and supplemented with 2iP, BA, Kin and NAA (MSM medium), and two elicitors [jasmonic acid (JA), and salicylic acid (SA)], on plant growth and accumulation of hypericins (hypericin and pseudohypericin) and hyperforin in shoot cultures of Hypericum hirsutum and H. maculatum. Our data suggested that culture of shoots on MS medium supplemented with BA (0.4 mg l−1) or Kin (0.4 mg l−1) enhanced production of hypericins in H. maculatum and hyperforin in H. hirsutum. Hypericins and hyperforin concentrations decreased in both species when TDZ (0.4 mg l−1) was added to the MS medium. Also, TDZ induced hyperhydric malformations and necrosis of regenerated shoots. Cultivation of H. maculatum on MSM medium resulted in approximately twofold increased production of hypericins compared to controls, and the growth of H. hirsutum shoots on the same medium led to a 6.16-fold increase in hyperforin production. Of the two elicitors, SA was more effective in stimulating the accumulation of hypericins. At 50 μM, SA enhanced the production of hypericin (7.98-fold) and pseudohypericin (13.58-fold) in H. hirsutum, and, at 200 μM, enhanced the production of hypericin (2.2-fold) and pseudohypericin (3.94-fold) in H. maculatum.
Study on psychoeducation enhancing results of adherence in patients with schizophrenia (SPERA-S): study protocol for a randomized controlled trial

BACKGROUND
Poor adherence to pharmacotherapy negatively affects the course and the outcome of schizophreniaspectrum psychoses, enhancing the risk of relapse. Falloon and coworkers developed a Psychoeducation Program aimed at improving communication and problem-solving abilities in patients and their families. This study set out to evaluate changes in adherence to pharmacotherapy in patients diagnosed with schizophrenia-spectrum psychoses, by comparing one group exposed to the Falloon Psychoeducation Program (FPP) with another group exposed to family supportive therapy with generic information on the disorders.


METHODS
340 patients diagnosed with schizophrenia and related disorders according to standardized criteria from 10 participating units distributed throughout the Italian National Health System (NHS), will be enrolled with 1:1 allocation by the method of blocks of randomized permutations. Patients will be reassessed at 6, 12 and 18 months after start of treatment (duration: 6 months).The primary objective is to evaluate changes in adherence to pharmacotherapy after psychoeducation. Adherence will be assessed at three-month intervals by measuring blood levels of the primary prescribed drug using high pressure liquid chromatography, and via the Medication Adherence Questionnaire and a modified version of the Adherence Interview. Secondary objectives are changes in the frequency of relapse and readmission, as the main indicator of the course of the disorder.Enrolled patients will be allocated to the FPP (yes/no) randomly, 1:1, in a procedure controlled by the coordinating unit; codes will be masked until the conclusion of the protocol (or the occurrence of a severe negative event). The raters will be blind to treatment allocation and will be tested for blinding after treatment completion. Intention-to-treat will be applied in considering the primary and secondary outcomes. Multiple imputations will be applied to integrate the missing data. The study started recruitment in February 2013; the total duration of the study is 27 months.


DISCUSSION
If the psychoeducation program proves effective in improving adherence to pharmacotherapy and in reducing relapse and readmissions, its application could be proposed as a standard adjunctive psychosocial treatment within the Italian NHS.


TRIAL REGISTRATION
Protocol Registration System of ClinicalTrials.gov NCT01433094; registered on 20 August 2011; first patient was randomized on 12 February 2013.
An efficient emotion detection scheme for popular music

With the rapid growth of multimedia information, the ability to efficiently manage data from large amount of multimedia database has become a crucial issue. In this paper, a framework for music emotion detection is proposed. First, a Thayer's 2-Dimentinal model that represents the music emotion space is employed as our emotion model. Second, three features such as intensity, rhythm regularity, and tempo are extracted to describe a music clip. Then, features are trained by constructing Gaussian Mixture Models (GMM). Finally, the likelihood radios of test music clips to GMM are calculated for emotion identification. Experiemtal results show that the average recall and precision all are up to 80% for the database that is comprised of 145 music clips.
Immune response of healthy horses to DNA constructs formulated with a cationic lipid transfection reagent

BACKGROUND
Deoxyribonucleic acid (DNA) vaccines are used for experimental immunotherapy of equine melanoma. The injection of complexed linear DNA encoding interleukin (IL)-12/IL-18 induced partial tumour remission in a clinical study including 27 grey horses. To date, the detailed mechanism of the anti-tumour effect of this treatment is unknown.


RESULTS
In the present study, the clinical and cellular responses of 24 healthy horses were monitored over 72 h after simultaneous intradermal and intramuscular application of equine IL-12/IL-18 DNA (complexed with a transfection reagent) or comparative substances (transfection reagent only, nonsense DNA, nonsense DNA depleted of CG). Although the strongest effect was observed in horses treated with expressing DNA, horses in all groups treated with DNA showed systemic responses. In these horses treated with DNA, rectal temperatures were elevated after treatment and serum amyloid A increased. Total leukocyte and neutrophil counts increased, while lymphocyte numbers decreased. The secretion of tumour necrosis factor alpha (TNFα) and interferon gamma (IFNγ) from peripheral mononuclear blood cells ex vivo increased after treatments with DNA, while IL-10 secretion decreased. Horses treated with DNA had significantly higher myeloid cell numbers and chemokine (C-X-C motif) ligand (CXCL)-10 expression in skin samples at the intradermal injection sites compared to horses treated with transfection reagent only, suggesting an inflammatory response to DNA treatment. In horses treated with expressing DNA, however, local CXCL-10 expression was highest and immunohistochemistry revealed more intradermal IL-12-positive cells when compared to the other treatment groups. In contrast to non-grey horses, grey horses showed fewer effects of DNA treatments on blood lymphocyte counts, TNFα secretion and myeloid cell infiltration in the dermis.


CONCLUSION
Treatment with complexed linear DNA constructs induced an inflammatory response independent of the coding sequence and of CG motif content. Expressing IL-12/IL-18 DNA locally induces expression of the downstream mediator CXCL-10. The grey horses included appeared to display an attenuated immune response to DNA treatment, although grey horses bearing melanoma responded to this treatment with moderate tumour remission in a preceding study. Whether the different immunological reactivity compared to other horses may contributes to the melanoma susceptibility of grey horses remains to be elucidated.
The efficacy and safety of imeglimin as add-on therapy in patients with type 2 diabetes inadequately controlled with sitagliptin monotherapy.

OBJECTIVE
This 12-week study assessed the efficacy and tolerability of imeglimin as add-on therapy to the dipeptidyl peptidase-4 inhibitor sitagliptin in patients with type 2 diabetes inadequately controlled with sitagliptin monotherapy.


RESEARCH DESIGN AND METHODS
In a multicenter, randomized, double-blind, placebo-controlled, parallel-group study, imeglimin (1,500 mg b.i.d.) or placebo was added to sitagliptin (100 mg q.d.) over 12 weeks in 170 patients with type 2 diabetes (mean age 56.8 years; BMI 32.2 kg/m(2)) that was inadequately controlled with sitagliptin alone (A1C ≥7.5%) during a 12-week run-in period. The primary efficacy end point was the change in A1C from baseline versus placebo; secondary end points included corresponding changes in fasting plasma glucose (FPG) levels, stratification by baseline A1C, and percentage of A1C responders.


RESULTS
Imeglimin reduced A1C levels (least-squares mean difference) from baseline (8.5%) by 0.60% compared with an increase of 0.12% with placebo (between-group difference 0.72%, P < 0.001). The corresponding changes in FPG were -0.93 mmol/L with imeglimin vs. -0.11 mmol/L with placebo (P = 0.014). With imeglimin, the A1C level decreased by ≥0.5% in 54.3% of subjects vs. 21.6% with placebo (P < 0.001), and 19.8% of subjects receiving imeglimin achieved a decrease in A1C level of ≤7% compared with subjects receiving placebo (1.1%) (P = 0.004). Imeglimin was generally well tolerated, with a safety profile comparable to placebo and no related treatment-emergent adverse events.


CONCLUSIONS
Imeglimin demonstrated incremental efficacy benefits as add-on therapy to sitagliptin, with comparable tolerability to placebo, highlighting the potential for imeglimin to complement other oral antihyperglycemic therapies.
Body image disturbance and surgical decision making in egyptian post menopausal breast cancer patients

BACKGROUND
In most developing countries, as in Egypt; postmenopausal breast cancer cases are offered a radical form of surgery relying on their unawareness of the subsequent body image disturbance. This study aimed at evaluating the effect of breast cancer surgical choice; Breast Conservative Therapy (BCT) versus Modified Radical Mastectomy (MRM); on body image perception among Egyptian postmenopausal cases.


METHODS
One hundred postmenopausal women with breast cancer were divided into 2 groups, one group underwent BCT and the other underwent MRM. Pre- and post-operative assessments of body image distress were done using four scales; Breast Impact of Treatment Scale (BITS), Impact of Event Scale (IES), Situational Discomfort Scale (SDS), and Body Satisfaction Scale (BSS).


RESULTS
Preoperative assessment showed no statistical significant difference regarding cognitive, affective, behavioral and evaluative components of body image between both studied groups. While in postoperative assessment, women in MRM group showed higher levels of body image distress among cognitive, affective and behavioral aspects.


CONCLUSION
Body image is an important factor for postmenopausal women with breast cancer in developing countries where that concept is widely ignored. We should not deprive those cases from their right of less mutilating option of treatment as BCT.