LLukas22/scidocs huggingface dataset:
Prolonged thromboprophylaxis with Dalteparin during immobilization after ankle fracture surgery: a randomized placebo-controlled, double-blind study.

BACKGROUND
Skeletal trauma and immobilization are well-known risk factors for deep vein thrombosis (DVT) and pulmonary embolism (PE). While prophylaxis against thromboembolic complications has become routine after major orthopedic surgery, whether or not prophylaxis after minor surgery and lower limb immobilization is necessary is still under debate.


METHODS
In a double-blind, placebo-controlled study, 272 consecutive patients were randomized to receive either thromboprophylaxis with Dalteparin (n = 136) or placebo (n = 136) for 5 weeks after ankle fracture surgery. All patients received 1 week of initial treatment with Dalteparin before randomization. A unilateral phlebography was performed when the cast was removed.


RESULTS
The overall incidence of DVT was 21% (95% CI: 13-29%) in the Dalteparin group and 28% (CI: 19- 37%) in the placebo group (risk ratio = 0.8, CI: 0.6-1.1; p = 0.3). The incidence of proximal DVTs was 4% and 3%, respectively. No major bleeding occurred.


INTERPRETATION
We found no significant difference in the incidence of DVT between the 2 treatment groups and our results do not support prolonged thromboprophylaxis. The overall incidence of DVT was high, reflecting the potential risk of PE and post-thrombotic syndrome after ankle fracture surgery. Most of the DVTs were asymptomatic, however, and were located in distal veins.
A waveguide slot array antenna with integrated T-shaped filters in the corporate-feed circuit

In this paper, we demonstrate a waveguide slot array antenna by integration of T-shaped filters using the diffusion bonding of laminated thin metal plates. The excellent performance of the T-shaped filter has been experimentally verified by the in-band transmission and the out-of-band rejection of the fabricated antenna.
Effect of meditation on stress-induced changes in cognitive functions.

OBJECTIVES
The objective of this study was to study the effects of meditation on stress-induced changes in cognitive functions.


METHODS
The study was conducted on 32 healthy adult male student volunteers who had never practiced meditation before the study. The study consisted of practicing 20 minutes of guided meditation and administration of psychologic stress to the subjects. The psychologic stress was administered to the subjects by asking them to play a (preselected) stressful computer game. The subjects were asked to meditate either before or after the administration of psychologic stress. For the control group measurements, the subjects were asked to wait quietly for an equivalent period of meditation time.


OUTCOME MEASURES
The outcome measures were galvanic skin response (GSR), heart rate (HR), electromyography (EMG), sympathetic reactivity (QTc/QS2 ratio), cortisol, and acute psychologic stress scores. The central nervous system functions were assessed using Wechsler memory scale and visual-choice reaction time (VCRT). These parameters were measured both at the beginning and at the end of the intervention, using a pre-post experimental test design.


RESULTS
Computer game stress was associated with a significant increase in physiologic (GSR, EMG, HR, QTc/QS2) and psychologic (acute stress questionnaire scores) markers of stress. Meditation was associated with relaxation (significant decrease in GSR, EMG, QTc/QS2, and acute stress questionnaire scores). Meditation, if practiced before the stressful event, reduced the adverse effects of stress. Memory quotient significantly increased, whereas cortisol level decreased after both stress and meditation. VCRT showed no significant change.


CONCLUSIONS
Practice of meditation produced a relaxation response even in the young adult subjects who had never practiced meditation before. The practice of meditation reduced the physiologic stress responses without taking away the beneficial effect of stress, namely, improved memory scores.
The Analysis of IKEA's Value Chain Management Strategy

IKEA is the largest furniture retailer in the world. Their critical success factor is that IKEA can seamlessly integrate and optimize end-to-end supply chain to maximize customer value, eventually build their dominate position in entire value chain. This article summarizes and analyzes IKEA's successful practices of value chain management. Hopefully it can be a good reference or provide strategic insight for Chinese enterprises.
Clinical outcomes after arteriovenous fistula creation in chronic kidney disease.

BACKGROUND
Optimal timing of arteriovenous fistula (AVF) surgery in chronic kidney disease (CKD) is uncertain.


METHODS
A single-centre retrospective study of pre-dialysis CKD patients having first AVF surgery.


RESULTS
The median estimated glomerular filtration rate (eGFR) at the time of AVF surgery in 100 patients was 15 ml/min/1.73 m(2), with patients classified as having an early AVF if eGFR was >15 ml/min/1.73 m(2) (n = 46) or a late AVF if eGFR was ≤15 ml/min/1.73 m(2) (n = 54). In the eGFR ≤15 group, 81% of patients started haemodialysis (HD), compared with 63% of the eGFR >15 patients (p = 0.04). The median time to starting HD was 30.3 months in the eGFR >15 group compared to 10.7 months for the eGFR ≤15 group (log rank p = 0.018). There were no differences in the requirements for a dialysis catheter (eGFR >15 24% vs. eGFR ≤15 11%, p = 0.20) or additional access procedures between the two groups.


CONCLUSIONS
AVF surgery with an eGFR >15 ml/min/1.73 m(2) was associated with a higher risk of AVF non-use and a more prolonged time to the need for HD.
Frameworks for entity matching: A comparison

Entity matching is a crucial and difficult task for data integration. Entity matching frameworks provide several methods and their combination to effectively solve different match tasks. In this paper, we comparatively analyze 11 proposed frameworks for entity matching. Our study considers both frameworks which do or do not utilize training data to semiautomatically find an entity matching strategy to solve a given match task. Moreover, we consider support for blocking and the combination of different match algorithms. We further study how the different frameworks have been evaluated. The study aims at exploring the current state of the art in research prototypes of entity matching frameworks and their evaluations. The proposed criteria should be helpful to identify promising framework approaches and enable categorizing and comparatively assessing additional entity matching frameworks and their evaluations. 2009 Elsevier B.V. All rights reserved.
Prognostic value of echocardiography in normotensive patients with acute pulmonary embolism.

OBJECTIVES
The goal of the study was to evaluate the prognostic value of echocardiographic indices of right ventricular dysfunction (RVD) for prediction of pulmonary embolism-related 30-day mortality or need for rescue thrombolysis in initially normotensive patients with acute pulmonary embolism (APE).


BACKGROUND
There is no generally accepted echocardiographic definition of RVD used for prognosis in APE.


METHODS
We studied the prognostic value of a set of echocardiographic parameters in 411 consecutive patients (234 women, age 64 ± 18 years) with APE hemodynamically stable at admission.


RESULTS
Thirty-day APE-related mortality was 3% (14 patients), all-cause mortality was 5% (21 patients). Nine patients received thrombolysis as a result of hemodynamic deterioration, and 7 of them survived. The clinical endpoint (CE), which included APE-related death or thrombolysis, occurred in 21 patients. At univariable Cox analysis, the hazard ratio (HR) for CE of the right ventricular (RV)/left ventricular (LV) ratio was 7.3 (95% confidence interval [CI]: 2.0 to 27.3; p = 0.003). However, multivariable analysis showed that tricuspid annulus plane systolic excursion (TAPSE) was the only independent predictor (HR: 0.64, 95% CI: 0.54 to 0.7; p < 0.0001). Moreover, the area under the curve (AUC) in receiver-operating characteristic analysis for TAPSE (0.91, 95% CI: 0.856 to 0.935; p = 0.0001) in CE prediction was higher (p < 0.001) than AUC of RV/LV ratio (0.638, 95% CI: 0.589 to 0.686; p = 0.001). TAPSE ≤15 mm had a HR of 27.9 (95% CI: 6.2 to 124.6; p < 0.0001) and a positive predictive value (PPV) of 20.9% for CE with a 99% negative predictive value (NPV), whereas TAPSE ≤20 mm had a PPV of 9.2 with a 100% NPV. RV/LV ratios of >0.9 and >1.0 had a PPV of 13.2% and 14.4% and a NPV of 97% and 94.3%, respectively.


CONCLUSIONS
TAPSE is preferable to the RV/LV ratio for risk stratification in initially normotensive patients with APE. TAPSE ≤15 mm identifies patients with an increased risk of 30-day APE-related mortality, whereas TAPSE >20 mm can be used for identification of a very low-risk group.
Using Recurrent Neural Network for Learning Expressive Ontologies

Recently, Neural Networks have been proven extremely effective in many natural language processing tasks such as sentiment analysis, question answering, or machine translation. Aiming to exploit such advantages in the Ontology Learning process, in this technical report we present a detailed description of a Recurrent Neural Network based system to be used to pursue such goal.
A Combined Runtime Environment and Web-Based Development Environment for Web Application Engineering

In the last 5 years, server side application server technology became very popular. The two most popular, .NET and J2EE have a large mindshare in the commercial world. Application servers have raised the productivity of server side web developers. In this paper we give a short overview of the history of application servers, and try to answer the question: what options or features would raise the productivity even more? While building commercial websites at <GX>, we found out that that a combined web-based development environment and persistent runtime environment raised our productivity, even compared to .NET or J2EE environments. In this paper we describe such a system built at <GX>, which we called a WRDE (Web-based Runtime and Development Environment), and show the strength and weaknesses of this approach.
Effects of Pediococcus- and Saccharomyces-based probiotic (MitoMax) on coccidiosis in broiler chickens.

Coccidiosis is the major parasitic disease of poultry. In this study, the role of the commercial probiotic MitoMax which contains Pediococcus acidilactici and Saccharomyces boulardii was evaluated by measuring body weight gain, fecal oocyst shedding, and serum antibody responses as an alternative control method of prophylactic drug against coccidiosis. Day-old broiler chicks were fed regular or probiotic diets supplemented with MitoMax at 0.01%, 0.1%, or 1.0% of diet, and challenged 2 weeks later with 5000 oocysts of either Eimeria acervulina (EA) or Eimeria tenella (ET). Birds fed 1.0% or 0.1% MitoMax-supplemented diets in EA- or ET-infected groups shed less (P<0.05) oocysts than control-infected chickens. Also, chickens fed 0.1% MitoMax-supplemented diet and infected with EA exhibited higher (P<0.001) serum Eimeria-specific antibodies than other groups. These results demonstrate that MitoMax may enhance the resistance of birds against coccidiosis by enhancing humoral immunity when included at > or = 0.1% of the broiler diet.
Efficacy and safety of peginterferon alfa-2a (40KD) plus ribavirin in hepatitis C patients with advanced fibrosis and cirrhosis.

UNLABELLED
The objective of this study is to determine the efficacy and safety of peginterferon alfa-2a (40 KD)/ribavirin in patients with advanced fibrosis. Data from 341 genotype 1/4 patients (99 with bridging fibrosis/cirrhosis) treated for 48 weeks and 1547 genotype 2/3 patients (380 with bridging fibrosis/cirrhosis) treated for 16 or 24 weeks enrolled in three randomized international studies were analyzed. Sustained virological response (SVR) rates decreased progressively from 60% in genotype 1/4 patients without advanced fibrosis to 51% in those with bridging fibrosis and 33% in those with cirrhosis (trend test P = 0.0028); and from 76% to 61% and 57%, respectively, in genotype 2/3 patients treated for 24 weeks (trend test P < 0.0001). Irrespective of genotype, patients without advanced fibrosis were more likely to have an earlier response to treatment that was associated with higher SVR rates and lower relapse rates during untreated follow-up. Among patients with or without a diagnosis of advanced fibrosis, rates of SVR and relapse were similar for patients with similar responses in the first 12 weeks.


CONCLUSION
Compared with patients with less severe disease, SVR rates are significantly lower in patients with advanced fibrosis. However, irrespective of genotype and degree of fibrosis, the time to become hepatitis C virus (HCV) RNA undetectable was the strongest predictor of SVR.
Cloudlet-based Efficient Data Collection in Wireless Body Area Networks

Wireless Body Area Networks (WBANs) have developed as an effective solution for a wide range of healthcare, military and sports applications. Most of the proposed works studied efficient data collection from individual and traditional WBANs. Cloud computing is a new computing model that is continuously evolving and spreading. This paper presents a novel cloudlet-based efficient data collection system in WBANs. The goal is to have a large scale of monitored data of WBANs to be available at the end user or to the service provider in reliable manner. A prototype of WBANs, including Virtual Machine (VM) and Virtualized Cloudlet (VC) has been proposed for simulation characterizing efficient data collection in WBANs. Using the prototype system, we provide a scalable storage and processing infrastructure for large scale WBANs system. This infrastructure will be efficiently able to handle the large size of data generated by the WBANs system, by storing these data and performing analysis operations on it. The proposed model is fully supporting for WBANs system mobility using cost effective communication technologies of WiFi and cellular which are supported by WBANs and VC systems. This is in contrast of many of available mHealth solutions that is limited for high cost communication technology, such as 3G and LTE. Performance of the proposed prototype is evaluated via an extended version of CloudSim simulator. It is shown that the average power consumption and delay of the collected data is tremendously decreased by increasing the number of VMs and VCs. 2014 Elsevier B.V. All rights reserved.
Analysis of numerical methods for the simulation of deformable models

Simulating deformable objects based on physical laws has become the most popular technique for modeling textiles, skin, or volumetric soft objects like human tissue. The physical model leads to an ordinary differential equation. Recently, several approaches to fast algorithms have been proposed. In this work, more profound numerical background about numerical stiffness is provided. Stiff equations impose stability restrictions on a numerical integrator. Some one-step and multistep methods with adequate stability properties are presented. For an efficient implementation, the inexact Newton method is discussed. Applications to 2D and 3D elasticity problems show that the discussed methods are faster and give higher-quality solutions than the commonly used linearized Euler method.
Corporate Misreporting and Bank Loan Contracting

This paper is the first to study the effect of financial restatement on bank loan contracting. Compared with loans initiated before restatement, loans initiated after restatement have significantly higher spreads, shorter maturities, higher likelihood of being secured, and more covenant restrictions. The increase in loan spread is significantly larger for fraudulent restating firms than other restating firms. We also find that after restatement, the number of lenders per loan declines and firms pay higher upfront and annual fees. These results are consistent with banks using tighter loan contract terms to overcome risk and information problems arising from financial restatements. & 2008 Elsevier B.V. All rights reserved.
Use of Mobile Phones in Language Learning: Developing Effective Instructional Materials

With its widespread use and its features and functions such as mobility, reachability, localization, and personalization, mobile phone technology offers a great potential in learning environments. With this consideration, our first and foremost aim in this study has been to make use of this profound interest and potential, and contribute to the efforts to enhance existing educational practices, particularly in the developing regions of the world. Therefore, we developed instructional materials to be delivered through mobile phones operated in second generation GSM technology in order to improve English language learners' vocabulary acquisition. The multimedia messages in this study allowed students to see the definitions of words, example sentences, related visual representations, and pronunciations. After students finished reading multimedia messages, interactive short message service (SMS) quizzes for testing their learning were sent. This paper suggests some important points to consider while creating MMS content and a SMS quiz system for educational purposes.
Inattention and hyperactivity and the achievement gap among urban minority youth.

OBJECTIVES
To outline the prevalence and disparities of inattention and hyperactivity among school-aged urban minority youth, causal pathways through which inattention and hyperactivity adversely affects academic achievement, and proven or promising approaches for schools to address these problems.


METHODS
Literature review.


RESULTS
Approximately 4.6 million (8.4%) of American youth aged 6-17 have received a diagnosis of attention deficit/hyperactivity disorder (ADHD), and almost two thirds of these youth are reportedly under treatment with prescription medications. Urban minority youth are not only more likely to be affected but also less likely to receive accurate diagnosis and treatment. Causal pathways through which ADHD may affect academic achievement include sensory perceptions, cognition, school connectedness, absenteeism, and dropping out. In one study, youth with diagnosed ADHD were 2.7 times as likely to drop out (10.0% vs. 22.9%). A similar odds ratio for not graduating from high school was found in another prospective study, with an 8-year follow-up period (odds ratio = 2.4). There are many children who are below the clinical diagnostic threshold for ADHD but who exhibit signs and symptoms that interfere with learning. Evidence-based programs emphasizing functional academic and social outcomes are available.


CONCLUSIONS
Inattention and hyperactivity are highly and disproportionately prevalent among school-aged urban minority youth, have a negative impact on academic achievement through their effects on sensory perceptions, cognition, school connectedness, absenteeism, and dropping out, and effective practices are available for schools to address these problems. This prevalent and complex syndrome has very powerful effects on academic achievement and educational attainment, and should be a high priority in efforts to help close the achievement gap.
Efficacy and safety of immediate angioplasty versus ischemia-guided management after thrombolysis in acute myocardial infarction in areas with very long transfer distances results of the NORDISTEMI (NORwegian study on DIstrict treatment of ST-elevation myocardial infarction).

OBJECTIVES
The goal of this study was to compare a strategy of immediate transfer for percutaneous coronary intervention (PCI) with an ischemia-guided approach after thrombolysis in patients with very long transfer distances to PCI.


BACKGROUND
Thrombolysis remains the treatment of choice in ST-segment elevation myocardial infarction (STEMI) when primary PCI cannot be performed within 90 to 120 min. The optimal treatment after thrombolysis is still unclear.


METHODS
A total of 266 patients with acute STEMI living in rural areas with more than 90-min transfer delays to PCI were treated with tenecteplase, aspirin, enoxaparin, and clopidogrel and randomized to immediate transfer for PCI or to standard management in the local hospitals with early transfer, only if indicated for rescue or clinical deterioration. The primary outcome was a composite of death, reinfarction, stroke, or new ischemia at 12 months, and analysis was by intention to treat.


RESULTS
The primary end point was reached in 28 patients (21%) in the early invasive group compared with 36 (27%) in the conservative group (hazard ratio: 0.72, 95% confidence interval: 0.44 to 1.18, p = 0.19). The composite of death, reinfarction, or stroke at 12 months was significantly reduced in the early invasive compared with the conservative group (6% vs. 16%, hazard ratio: 0.36, 95% confidence interval: 0.16 to 0.81, p = 0.01). No significant differences in bleeding or infarct size were observed.


CONCLUSIONS
Immediate transfer for PCI did not improve the primary outcome significantly, but reduced the rate of death, reinfarction, or stroke at 12 months in patients with STEMI, treated with thrombolysis and clopidogrel in areas with long transfer distances. (Norwegian Study on District Treatment of ST-Elevation Myocardial Infarction; NCT00161005).
Increased risk of left heart valve regurgitation associated with benfluorex use in patients with diabetes mellitus: a multicenter study.

BACKGROUND
Benfluorex was withdrawn from European markets in June 2010 after reports of an association with heart valve lesions. The link between benfluorex and valve regurgitations was based on small observational studies and retrospective estimations. We therefore designed an echocardiography-based multicenter study to compare the frequency of left heart valve regurgitations in diabetic patients exposed to benfluorex for at least 3 months and in diabetic control subjects never exposed to the drug.


METHODS AND RESULTS
This reader-blinded, controlled study conducted in 10 centers in France between February 2010 and September 2011 prospectively included 376 diabetic subjects previously exposed to benfluorex who were referred by primary care physicians for echocardiography and 376 diabetic control subjects. Through the use of propensity scores, 293 patients and 293 control subjects were matched for age, sex, body mass index, smoking, dyslipidemia, hypertension, and coronary artery disease. The main outcome measure was the frequency of mild or greater left heart valve regurgitations. In the matched sample, the frequency and relative risk (odds ratio) of mild or greater left heart valve regurgitations were significantly increased in benfluorex patients compared with control subjects: 31.0% versus 12.9% (odds ratio, 3.55; 95% confidence interval, 2.03-6.21) for aortic and/or mitral regurgitation, 19.8% versus 4.7% (odds ratio, 5.29; 95% confidence interval, 2.46-11.4) for aortic regurgitation, and 19.4% versus 9.6% (odds ratio, 2.38; 95% confidence interval, 1.27-4.45) for mitral regurgitation.


CONCLUSIONS
Our results indicate that the use of benfluorex is associated with a significant increase in the frequency of left heart valve regurgitations in diabetic patients. The natural history of benfluorex-induced valve abnormalities needs further research.