LLukas22/scidocs huggingface dataset:
One-Legged Cycle Training for Chronic Obstructive Pulmonary Disease. A Pragmatic Study of Implementation to Pulmonary Rehabilitation.

RATIONALE
In patients with chronic obstructive pulmonary disease (COPD), partitioned exercise training using one-legged cycling leads to greater improvements in peak oxygen uptake than conventional two-legged cycling.


OBJECTIVES
We evaluated the feasibility of incorporating one-legged cycling as the principal aerobic training modality for pulmonary rehabilitation in COPD.


METHODS
Physiotherapists underwent four teaching sessions about the principles and practical implementation of one-legged cycling training. Patients enrolled in a pulmonary rehabilitation program underwent 6-8 weeks of training in which one-legged cycling three times per week was the principal aerobic exercise activity. Participants cycled for 15 minutes with each leg, in each session. An incremental cardiopulmonary exercise test was completed before and after pulmonary rehabilitation along with standard pulmonary rehabilitation outcome measures. Participants and physiotherapists completed a satisfaction survey at the end of the program.


MEASUREMENTS AND MAIN RESULTS
A total of 22 out of 32 participants (14 male; mean [SD] age, 66 [7] years; FEV1% predicted, 32 [17]%; median [interquartile range] Medical Research Council dyspnea scale, 3.5 [3.0-4.3]) completed pulmonary rehabilitation. Peak oxygen uptake increased 1.1 (0.4-1.7) ml·min(-1)·kg(-1) (8%) from baseline (P<0.01). The mean (95% confidence interval) 6-minute-walk test distance improved by 72 (45-98) m (P=0.001). The change in the Chronic Respiratory Questionnaire total score of 1.6 (1.1-2.1; P<0.001) was achieved by improvement in all four domains above the clinically important difference. All the physiotherapists considered one-legged cycling safe and would continue to prescribe it; 75% of participants would recommend it to other patients.


CONCLUSIONS
One-legged cycling was successfully implemented into a "real-life" pulmonary rehabilitation program, demonstrating improvements in cardiorespiratory fitness with associated improvement in function for patients with moderate/severe COPD. One-legged cycling should be recommended in professional pulmonary rehabilitation guidelines as an option for exercise training and be available in other pulmonary rehabilitation programs. Clinical trial registered with www.clinicaltrials.gov (NCT01930526).
Batch normalized recurrent neural networks

Recurrent Neural Networks (RNNs) are powerful models for sequential data that have the potential to learn long-term dependencies. However, they are computationally expensive to train and difficult to parallelize. Recent work has shown that normalizing intermediate representations of neural networks can significantly improve convergence rates in feed-forward neural networks [1]. In particular, batch normalization, which uses mini-batch statistics to standardize features, was shown to significantly reduce training time. In this paper, we investigate how batch normalization can be applied to RNNs. We show for both a speech recognition task and language modeling that the way we apply batch normalization leads to a faster convergence of the training criterion but doesn't seem to improve the generalization performance.
Emotional design in multimedia learning : Effects of shape and color on affect and learning

We examine design factors that may evoke positive emotions in learners and investigate the effects of these positive emotions on learning. Recent research showed that the emotional design of multimedia learning material can inducepositiveemotions in learners that in turn facilitate comprehensionand transfer.We sought to replicate these results with a different population and different mood induction procedure and examine individual emotions, and to decompose the effects of the design elements of color and shape. Study 1 showed that well-designed materials induced positive emotions and facilitated comprehension, though transfer performance was not affected by emotional design. Study 2 found that round face-like shapes both alone and in conjunctionwithwarm color induced positive emotions.Warm colors alone, however, did not affect learners’ emotions. Comprehensionwas facilitated bywarmcolors and round face-like shapes, independentlyaswell as together. Transfer was facilitated by round face-like shapes when used with neutral colors. 2013 Elsevier Ltd. All rights reserved.
A global test for groups of genes: testing association with a clinical outcome

MOTIVATION
This paper presents a global test to be used for the analysis of microarray data. Using this test it can be determined whether the global expression pattern of a group of genes is significantly related to some clinical outcome of interest. Groups of genes may be any size from a single gene to all genes on the chip (e.g. known pathways, specific areas of the genome or clusters from a cluster analysis).


RESULT
The test allows groups of genes of different size to be compared, because the test gives one p-value for the group, not a p-value for each gene. Researchers can use the test to investigate hypotheses based on theory or past research or to mine gene ontology databases for interesting pathways. Multiple testing problems do not occur unless many groups are tested. Special attention is given to visualizations of the test result, focussing on the associations between samples and showing the impact of individual genes on the test result.


AVAILABILITY
An R-package globaltest is available from http://www.bioconductor.org
Audiovisual News, Cartoons, and Films as Sources of Authentic Language Input and Language Proficiency Enhancement.

In today’s audiovisually driven world, various audiovisual programs can be incorporated as authentic sources of potential language input for second language acquisition. In line with this view, the present research aimed at discovering the effectiveness of exposure to news, cartoons, and films as three different types of authentic audiovisual programs on improving the language proficiency of low level language learners. To this end, 60 low level language learners were selected based on a language proficiency test and were assigned into three groups as group one, two, and three randomly. During the study which lasted for 10 weeks, the first group of the participants had exposure to a sample selected audiovisual materials from news, the second group of the participants had exposure to a sample selected audiovisual materials from cartoons, and the third group of the participants had exposure to a sample selected audiovisual material from various films. At the end of the study, another sample language proficiency test was administered to all the three groups to find out which group could gain significant language proficiency improvement. The results of the post-test were indicative of the fact that group one (news) failed to improve its language proficiency. In contrast, groups two (cartoons) and three (films) could improve their language proficiency. More importantly, the cartoon group participants’ improvement was more significant than that of the film group. The results showed that audiovisual programs generally are a great source of language input for teaching purposes. However, more caution should be given to the selection of the type of audiovisual programs for low level proficiency learners. Cartoons and films with good story lines seem to motivate the learners to absorb the language input better and have a significant effect on the language improvement.
The uses and impacts of medico-legal evidence in sexual assault cases : a global review

Background The review summarized here provides a global overview of the uses and impacts of medico-legal evidence in cases of sexual assault of adolescents and adults. It examines the existing peer-reviewed scholarly and grey literature from industrialized and developing regions. Over 400 items on sexual assault, including books, journal articles, news articles, research reports, annual reports, discussion papers and monographs, were examined. The review outlines the historical and contemporary medico-legal responses to sexual assault victims, broadly describing the professionals, protocols and procedures involved in the collection and processing of medico-legal evidence. Findings are presented from studies that have evaluated the legal impact of such evidence in sexual assault cases, and factors that may create barriers to its successful use in criminal justice proceedings are discussed. The review identifies salient knowledge gaps and offers research recommendations for addressing them.
Outpatient Therapeutic Feeding Program Outcomes and Determinants in Treatment of Severe Acute Malnutrition in Tigray, Northern Ethiopia: A Retrospective Cohort Study

BACKGROUND
Outpatient Therapeutic feeding Program (OTP) brings the services for management of Severe Acute Malnutrition (SAM) closer to the community by making services available at decentralized treatment points within the primary health care settings, through the use of ready-to-use therapeutic foods, community outreach and mobilization. Little is known about the program outcomes. This study revealed the levels of program outcome indictors and determinant factors to recovery rate.


METHODS
A retrospective cohort study was conducted on 628 children who had been managed for SAM under OTP from April/2008 to January/2012. The children were selected using systematic random sampling from 12 health posts and 4 health centers. The study relied on information of demographic characteristics, anthropometries, Plumpy'Nut, medical problems and routine medications intakes. The results were estimated using Kaplan-Meier survival curves, log-rank test and Cox-regression.


RESULTS
The recovery, defaulter, mortality and weight gain rates were 61.78%, 13.85%, 3.02% and 5.23 gm/kg/day, respectively. Routine medications were administered partially and children with medical problems were managed inappropriately under the program. As a child consumed one more sachet of Plumpy'Nut, the recovery rate from SAM increased by 4% (HR = 1.04, 95%-CI = 1.03, 1.05, P<0.001). The adjusted hazard ratios to recovery of children with diarrhea, appetite loss with Plumpy'Nut and failure to gain weight were 2.20 (HR = 2.20, 95%-CI = 1.31, 3.41, P = 0.001), 4.49 (HR = 1.74, 95%-CI = 1.07, 2.83, P = 0.046) and 3.88 (HR = 1.95, 95%-CI = 1.17, 3.23, P<0.001), respectively. Children who took amoxicillin and de-worming had 95% (HR = 1.95, 95%-CI = 1.17, 3.23) and 74% (HR = 1.74, 95%-CI = 1.07, 2.83) more probability to recover from SAM as compared to those who didn't take them.


CONCLUSIONS
The OTP was partially successful. Management of children with comorbidities under the program and partial administration of routine drugs were major threats for the program effectiveness. The stakeholders should focus on creating the capacity of the OTP providers on proper management of SAM to achieve fully effective program.
Factors influencing the use of ambulance among patients with acute coronary syndrome: results of two centers in Turkey.

OBJECTIVE
In this study, we aimed to identify the factors influencing the use of ambulance among patients admitted to two Turkish hospitals with acute coronary syndrome (ACS).


METHODS
Overall, 330 with a mean age of 55±13 years, hospitalized patients with ACS at 2 different hospitals were included in this prospective cohort study. The factors influencing the use of ambulance hospital were investigated through a questionnaire. The comparisons were made between two groups regarding use of ambulance. The predictors of the use of ambulance were determined using multiple logistic regression analysis.


RESULTS
Despite the high rate of knowing the emergency service number of "112", of the 330 patents, only 96 (29%) used ambulance. Ambulance users had shorter arrival duration with median of 60 min vs 120 min (p=0.03). Presenting with ST elevation myocardial infarction (OR=3.127, 95% CI: 1.555-6.2877, p<0.001), severity of chest pain (OR=2.665, 95% CI: 1.938-3.665, p<0.001), presence of accompanying symptoms such as dyspnea (OR= 5.510, 95% CI: 2.614-11.614, p<0.001), dizziness (OR=4.172, 95% CI: 1.901-9.154, p<0.001) and vomiting (OR=3.756, 95% CI: 1.521-9.272, p=0.004), knowledge of cardiac risk factors (OR=10.512, 95% CI: 4.497-24.572, p<0.001) or chest pain related to heart attack and the importance of quickly seeking for medical care by calling ambulance (OR= 4.184, 95% CI: 2.528-6.926, p<0.001) are the factors associated with ambulance use.


CONCLUSION
Using ambulance was in a very low rate among our study patients with ACS. Severity of symptoms, type of ACS and knowledge are seemed to be related with increased ambulance use. Informative health educational programs can be organized to achieve a behavioral change in using of ambulance.
Internet Car Retailing

This paper investigates the effect of Internet car referral services on dealer pricing of automobiles in California. Combining data from J.D. Power and Associates and Autobytel.com, a major online auto referral service, we compare online transaction prices to regular “street” prices. We find that the average customer of this online service pays approximately 2% less for her car, which corresponds to about $450 for the average car. Fifteen percent of the savings comes from making the purchase at a low-price dealership affiliated with the web service. The remaining 85% of the savings seem to be due to the bargaining power of the referral service and the lower cost of serving an online consumer. Dealer price dispersion declines with online sales, indicating we are picking up more than a selection effect. Online consumers who indicate they are ready to buy in the next two days pay even lower prices. Dealers pay less for an online customer’s trade-in vehicle, although on-line customers are still better off overall than offline customers. Dealer average gross margin on an online vehicle sale is lower than an equivalent offline sale. However, because online consumers may be cheaper to serve and online sales are likely to be new business for the dealerships, web-affiliated dealers are likely to be better off. Consumers who use the web do better than at least 61% of offline consumers.
Aggregation and Correlation of Intrusion-Detection Alerts

This paper describes an aggregation and correlation algorithm used in the design and implementation of an intrusion-detection console built on top of the Tivoli Enterprise Console (TEC). The aggregation and correlation algorithm aims at acquiring intrusion-detection alerts and relating them together to expose a more condensed view of the security issues raised by intrusion-detection systems.
Automatic semantic modeling of indoor scenes from low-quality RGB-D data using contextual information

We present a novel solution to automatic semantic modeling of indoor scenes from a sparse set of low-quality RGB-D images. Such data presents challenges due to noise, low resolution, occlusion and missing depth information. We exploit the knowledge in a scene database containing 100s of indoor scenes with over 10,000 manually segmented and labeled mesh models of objects. In seconds, we output a visually plausible 3D scene, adapting these models and their parts to fit the input scans. Contextual relationships learned from the database are used to constrain reconstruction, ensuring semantic compatibility between both object models and parts. Small objects and objects with incomplete depth information which are difficult to recover reliably are processed with a two-stage approach. Major objects are recognized first, providing a known scene structure. 2D contour-based model retrieval is then used to recover smaller objects. Evaluations using our own data and two public datasets show that our approach can model typical real-world indoor scenes efficiently and robustly.
Congenital malalignment of the great toenails mimicking onychomycosis.

A healthy 2-year-old girl was referred for toenail thickening and yellow discoloration; she was otherwise asymptomatic. The patient had no history of diabetes, infection, or trauma to her toenails. Physical examination revealed both great toenails to have marked thickening of the nail plate with closely spaced transverse superficial ridging, lack of luster, and dark tanyellowish discoloration (Figure 1). There was no subungual debris. There was mild separation of the nail plate from the underlying nail bed (onycholysis) and subungual hemorrhage on her right great toenail. Micronized toenail clippings failed to grow dermatophytes or nondermatophyte yeasts or molds. The bilateral presentation, persistence, absence of a history of trauma, and negative fungal culture confirm the diagnosis of congenital malalignment of the great toenails. This condition, which is often misdiagnosed and treated as onychomycosis, may occur in 1% to 2% of children (personal communication: R. Baran. E-mail, June 24, 2003). Congenital malalignment of the great toenail describes the condition in which the longitudinal axis of the nail is laterally deviated from birth (Figure 2). A malaligned nail matrix causes angular lateral nail plate growth. The toenails develop transverse ridges, appear thickened, and acquire gray, green, or brown discoloration. The ridges occur at regular intervals and appear to result from repeated microtrauma to the nail matrix. Hemorrhage and infection cause discoloration. In addition, they may be tender to palpation. One or both great toenails may be involved, and other toenails are occasionally also affected. Associated paronychia frequently develops. Properly fitting footwear reduces microtrauma that causes transverse ridging. Treatment may involve surgical realignment of the nail matrix. Spontaneous improvement by 5 and 10 years of age, however, has also been reported. Although toenail disorders in children are rare, recognition of
Making social choices from individuals' CP-nets

CP-nets are an attractive model for representing individual preferences, in part because they allow us to find the best outcome for an agent in time that is proportional to just the number of features in an outcome. In this paper, we investigate whether similar efficiencies can apply to finding the best social outcome for agents whose individual preferences are captured in CP-nets. Because CP-nets provide only qualitative information, we adopt a way to compare outcomes across agents based on each outcome's relative standing in the individuals' spaces of possible outcomes. This in turn guides the search through the outcome preference graphs that are induced by the agents' CP-nets to find the optimal social outcome. Because these induced preference graphs are exponential in the number of features, we examine the conditions under which the agents can search directly using their CP-nets, and show that our approach yields near-optimal social outcomes in exponentially less time.
The main determinant of hypotension in nitroglycerine tilt-induced vasovagal syncope.

BACKGROUND
The aim of the study was to assess the main determinant of the fall in blood pressure (BP) responsible for the head-up tilt testing-induced syncope.


METHODS AND RESULTS
The study involved 200 patients (mean age 42 ± 3; 81 male) with syncope of unknown origin after the first evaluation. According to the response to the diagnostic tilt test, the population study was divided into four groups: Group I with mixed vasovagal syncope; Group II with cardioinhibitory syncope; Group III with vasodepressive syncope; Group IV: 40 patients with clinical syncope but no tilt-induced syncope. Finger arterial BP (Portapres, TNO, Amsterdam, the Netherlands) was recorded during tilt testing. Left ventricular stroke volume (SV), cardiac output (CO), and total peripheral resistance (TPR) were computed from the pressure pulsations (Modelflow, TNO, Amsterdam, the Netherlands). During syncopal phase, the TPR decreased significantly in Group III, and increased in Group I and in Group II. CO decreased in Group I and in Group II and did not change significantly in Group III. SV decreased significantly in all groups.


CONCLUSIONS
Our data showed that the arterial system appears to be the main determinant of the BP fall in vasodepressive vasovagal syncope; while the impaired constrictive response of the venous system, leading to reduced venous return to the heart, appears to be the main determinant of BP fall in mixed and cardioinhibitory vasovagal syncope.
Correction of secondary cleft lip deformity: the whistle flap procedure.

BACKGROUND
The Kapetansky flap was described to repair a whistle deformity or central vermilion defect following a primary bilateral cleft lip repair. The authors studied a modification of this technique, called the Whistle (wide-hinged island swing transposition labial enhancement) flap, to correct a wide array of secondary cleft lip deformities.


METHODS
Patients with secondary cleft lip deformity who underwent the Whistle flap correction were studied (n = 21). Vertical lip height, lateral lip projections, and three-dimensional volumetric measurements were recorded along with physician and parent-patient satisfaction surveys.


RESULTS
From 1994 to 2006, 23 Whistle flap procedures were performed on 21 cleft lip patients (bilateral, n = 13; unilateral, n = 8). The average age at surgery was 15.4 years (range, 13 to 21 years). The average follow-up was 27.6 months. The vertical height of the cleft side Cupid's bow to vermilion bottom had a mean increase of 164 percent. Lateral projection of the upper lip showed a mean increase of 117 percent. Preoperatively, patients exhibited mean volumetric asymmetry of 29.4 percent, and this was reduced following treatment to approximately 3.1 percent. Physician satisfaction using a modified Whitaker classification (categories I through IV) demonstrated that 56 percent of patients were category I (no refinements necessary) and 44 percent were category II (minor revisions are advisable). Parent-patient satisfaction in the follow-up period was a mean of 3.5 as measured using a five-point scale ranging from 0 to 4. There were minimal perioperative complications.


CONCLUSION
The Whistle flap procedure provided a versatile and reliable option for the correction of vermilion defects from secondary cleft lip deformities.
Alleviation of cancerous pain by external compress with Xiaozheng Zhitong Paste.

OBJECTIVE
To observe the clinical effectiveness of a topical application of Xiaozheng Zhitong: Paste (, XZP) in alleviating the cancerous pain of patients with middle/late stage cancer


METHODS
By: adopting a random number table, 124 patients enrolled were randomized into the treatment group (64 patients) and the control group (60 patients). In addition to the basic therapy [including the three-ladder (3L) analgesia] used in both groups, topical application of XZP was given to patients in the treatment group for pain alleviation. The analgesic efficacy was recorded in terms of pain intensity, analgesia initiating time and sustaining time, and the optimal analgesic effect revealing time. Meanwhile, the quality of life (QOL) and adverse reactions that occurred in patients were recorded as well.


RESULTS
The total effective rate in the treatment group was: 84.38% (54/64), and in the control group it was 88.33% (53/60), showing no significant difference between them (P>0.05), but the analgesia initiating time and the optimal analgesia effect revealing time in the treatment group were significantly shorter (both P<0.01). Moreover, XZP was better in improving patients' QOL, showing more significant improvements in the treatment group than those in the control group in aspects of mental condition, walking capacity, working capacity, social acceptability, sleep and joy of living (P<0.05 or P<0.01). Lower incidence of adverse reactions, such as nausea, vomiting, mouth dryness, dizziness, etc., especially constipation, was noted in the treatment group (P<0.05 or P<0.01).


CONCLUSION
Applying an external compress: of XZP showed a synergistic action with 3L analgesia for shortening the initiating time and the optimal effect revealing time, and could evidently enhance patients' QOL with fewer adverse reactions.