LLukas22/scidocs huggingface dataset:
An innovative approach of QRS segmentation based on first-derivative, Hilbert and Wavelet Transforms.

The QRS detection and segmentation processes constitute the first stages of a greater process, e.g., electrocardiogram (ECG) feature extraction. Their accuracy is a prerequisite to a satisfactory performance of the P and T wave segmentation, and also to the reliability of the heart rate variability analysis. This work presents an innovative approach of QRS detection and segmentation and the detailed results of the proposed algorithm based on First-Derivative, Hilbert and Wavelet Transforms, adaptive threshold and an approach of surface indicator. The method combines the adaptive threshold, Hilbert and Wavelet Transforms techniques, avoiding the whole ECG signal preprocessing. After each QRS detection, the computation of an indicator related to the area covered by the QRS complex envelope provides the detection of the QRS onset and offset. The QRS detection proposed technique is evaluated based on the well-known MIT-BIH Arrhythmia and QT databases, obtaining the average sensitivity of 99.15% and the positive predictability of 99.18% for the first database, and 99.75% and 99.65%, respectively, for the second one. The QRS segmentation approach is evaluated on the annotated QT database with the average segmentation errors of 2.85±9.90ms and 2.83±12.26ms for QRS onset and offset, respectively. Those results demonstrate the accuracy of the developed algorithm for a wide variety of QRS morphology and the adaptation of the algorithm parameters to the existing QRS morphological variations within a single record.
The association between preoperative clinical risk factors and in-hospital strokes and death following carotid endarterectomy in South African patients

Background: Current surgical management of carotid artery disease includes carotid endarterectomy (CEA). In-hospital strokes and death following CEA might be associated with preinduction blood pressure (BP) measurements and other clinical risk factors.Method: The aim of our study was to determine whether or not there is an association between preinduction BP, other clinical risk factors, and in-hospital strokes or death following CEA in a cohort of South African patients. We collected data from medical records relating to clinical risk factors in patients, preinduction BP measurements, and in-hospital strokes and death, following CEA. The association between preinduction BP and clinical risk factors, and postoperative neurological morbidity and mortality, was analysed using univariate statistical methods.Results: Our cohort consisted of 76 patients who underwent CEA. Eight of these patients had in-hospital strokes or death following their surgery. An association between a history of hypertension or other ...
Automatic Scoring of Multiple Semantic Attributes With Multi-Task Feature Leverage: A Study on Pulmonary Nodules in CT Images

The gap between the computational and semantic features is the one of major factors that bottlenecks the computer-aided diagnosis (CAD) performance from clinical usage. To bridge this gap, we exploit three multi-task learning (MTL) schemes to leverage heterogeneous computational features derived from deep learning models of stacked denoising autoencoder (SDAE) and convolutional neural network (CNN), as well as hand-crafted Haar-like and HoG features, for the description of 9 semantic features for lung nodules in CT images. We regard that there may exist relations among the semantic features of “spiculation”, “texture”, “margin”, etc., that can be explored with the MTL. The Lung Image Database Consortium (LIDC) data is adopted in this study for the rich annotation resources. The LIDC nodules were quantitatively scored w.r.t. 9 semantic features from 12 radiologists of several institutes in U.S.A. By treating each semantic feature as an individual task, the MTL schemes select and map the heterogeneous computational features toward the radiologists’ ratings with cross validation evaluation schemes on the randomly selected 2400 nodules from the LIDC dataset. The experimental results suggest that the predicted semantic scores from the three MTL schemes are closer to the radiologists’ ratings than the scores from single-task LASSO and elastic net regression methods. The proposed semantic attribute scoring scheme may provide richer quantitative assessments of nodules for better support of diagnostic decision and management. Meanwhile, the capability of the automatic association of medical image contents with the clinical semantic terms by our method may also assist the development of medical search engine.
Particle Physics and Cosmology

In this talk I review the present status of inflationary cosmology and its emergence as the basic paradigm behind the Standard Cosmological Model, with parameters determined today at better than 10% level from CMB and LSS observations.
Effects of varespladib methyl on biomarkers and major cardiovascular events in acute coronary syndrome patients.

OBJECTIVES
The purpose of this study was to investigate the effects of varespladib on cardiovascular biomarkers in acute coronary syndrome patients.


BACKGROUND
Secretory phospholipase A(2) (sPLA(2)) represents a family of proatherogenic enzymes that hydrolyze lipoprotein phospholipids, increasing their affinity for intimal proteoglycans; contribute to cholesterol loading of macrophages by nonscavenger receptor mediated pathways; and activate inflammatory pathways. In prospective studies, high sPLA(2)-IIA levels predicted major adverse cardiovascular events in acute coronary syndrome (ACS) and stable coronary heart disease patients.


METHODS
This randomized, double-blind, prospective controlled clinical trial (phase 2B) was designed to investigate the effects of sPLA(2) inhibition with varespladib 500 mg daily versus placebo as adjunctive therapy to atorvastatin 80 mg daily on biomarkers (low-density lipoprotein cholesterol [LDL-C], high-sensitivity C-reactive protein [hsCRP], and sPLA(2)-IIA levels), major adverse cardiovascular events (unstable angina, myocardial infarction, death), and safety. In all, 625 ACS subjects were randomized within 96 h of the index event and treated for a minimum of 6 months.


RESULTS
After 8 weeks (primary efficacy end point), varespladib/atorvastatin reduced mean LDL-C levels from baseline by 49.6% compared with 43.4% with placebo/atorvastatin (p = 0.002). Respective 8-week median reductions in sPLA(2)-IIA levels were 82.4% and 15.6% (p < 0.0001), and hsCRP levels were lowered by 75.0% and 71.0% (p = 0.097). At 24 weeks, respective reductions with varespladib and placebo were as follows: LDL-C 43.5% versus 37.6% (p < 0.05), hsCRP 79.8% versus 77.0% (p = 0.02), and sPLA(2)-IIA 78.5% versus 6.4% (p < 0.0001). Major adverse cardiovascular events were not different from placebo 6 months post-randomization (7.3% varespladib vs. 7.7% placebo). No treatment differences in elevated liver function studies on >1 occasion were observed.


CONCLUSIONS
Varespladib therapy effectively reduced LDL-C and inflammatory biomarkers in ACS patients treated with conventional therapy including atorvastatin 80 mg daily. There were no treatment differences in clinical cardiovascular events. (FRANCIS [Fewer Recurrent Acute Coronary Events With Near-Term Cardiovascular Inflammation Suppression]-ACS Trial: A Study of the Safety and Efficacy of A 002 in Subjects With Acute Coronary Syndromes; NCT00743925).
Online grocery retailing: what do consumers think?

Purpose – To use the theory of planned behavior (TPB) as a theoretical framework to explore in depth the range of beliefs held by consumers about internet shopping in general and internet grocery shopping in particular. Design/methodology/approach – Seven focus group interviews, four in the United Kingdom and three in Denmark, were conducted among consumers with different degrees of experience with internet grocery shopping. This diversification of respondents was chosen to capture a broad range of the consumer beliefs that predict intentions to buy groceries online or not. The TPB framework was used to construct the interview guide that was followed in all focus groups. Findings – An unexpected result of the explorative study was that the seven groups consisting of more or less experienced internet shoppers differed only little in their pool of beliefs (outcome and control beliefs). Beliefs about internet grocery shopping, positive as well as negative, were remarkably congruent across groups. In the minds of consumers, internet grocery shopping is an advantage compared with conventional grocery shopping in terms of convenience, product range and price. Disadvantages, which could act as mental barriers, are, for instance, the risk of receiving inferior quality groceries and the loss of the recreational aspect of grocery shopping. Research limitations/implications – An important potential limitation of this research is the choice of focus groups as research methodology, which can prevent the elicitation of certain types of beliefs. If important beliefs concern issues of a more sensitive, personal character they are not likely to be mentioned in a focus group. Another limitation is the explorative nature of the research, which makes it impossible to attach weights to the importance of the elicited beliefs in predicting internet shopping behavior. Practical implications – The findings could be used to direct attention to consumer beliefs about internet grocery shopping which have the potential of acting as barriers to this line of e-commerce. Originality/value – To shed some light on the role of consumers in an underperforming and understudied branch of internet retailing. Barriers in the consumers’ minds to shop for groceries online are identified using an established theoretical framework.
Biomechanical evaluation of knee joint laxities and graft forces after anterior cruciate ligament reconstruction by anteromedial portal, outside-in, and transtibial techniques.

BACKGROUND
Recently, anatomic anterior cruciate ligament (ACL) reconstruction is emphasized to improve joint laxity and to potentially avert initiation of cartilage degeneration. There is a paucity of information on the efficacy of ACL reconstructions by currently practiced tunnel creation techniques in restoring normal joint laxity.


STUDY DESIGN
Controlled laboratory study.


HYPOTHESIS
Anterior cruciate ligament reconstruction by the anteromedial (AM) portal technique, outside-in (OI) technique, and modified transtibial (TT) technique can equally restore the normal knee joint laxity and ACL forces.


METHODS
Eight fresh-frozen human cadaveric knee specimens were tested using a robotic testing system under an anterior tibial load (134 N) at 0°, 30°, 60°, and 90° of flexion and combined torques (10-N·m valgus and 5-N·m internal tibial torques) at 0° and 30° of flexion. Knee joint kinematics, ACL, and ACL graft forces were measured in each knee specimen under 5 different conditions (ACL-intact knee, ACL-deficient knee, ACL-reconstructed knee by AM portal technique, ACL-reconstructed knee by OI technique, and ACL-reconstructed knee by TT technique).


RESULTS
Under anterior tibial load, no significant difference was observed between the 3 reconstructions in terms of restoring anterior tibial translation (P > .05). However, none of the 3 ACL reconstruction techniques could completely restore the normal anterior tibial translations (P < .05). Under combined tibial torques, both AM portal and OI techniques closely restored the normal knee anterior tibial translation (P > .05) at 0° of flexion but could not do so at 30° of flexion (P < .05). The ACL reconstruction by the TT technique was unable to restore normal anterior tibial translations at both 0° and 30° of flexion under combined tibial torques (P < .05). Forces experienced by the ACL grafts in the 3 reconstruction techniques were lower than those experienced by normal ACL under both the loading conditions.


CONCLUSION
Anterior cruciate ligament reconstructions by AM portal, OI, and modified TT techniques are biomechanically comparable with each other in restoring normal knee joint laxity and in situ ACL forces.


CLINICAL RELEVANCE
Anterior cruciate ligament reconstructions by AM portal, OI, and modified TT techniques result in similar knee joint laxities. Technical perils and pearls should be carefully considered before choosing a tunnel creating technique.
The Achilles tendon Total Rupture Score (ATRS): development and validation.

BACKGROUND
There is a need for a patient-relevant instrument to evaluate outcome after treatment in patients with a total Achilles tendon rupture.


PURPOSE
To develop and validate a new patient-reported instrument for measuring outcome after treatment for total Achilles tendon rupture.


STUDY DESIGN
Cohort study (diagnosis); Level of evidence, 1.


METHODS
Development of this instrument consisted of item generation and test construction, item reduction, validation, evaluation of structure and internal consistency, test-retest, and test for responsiveness. The final version, the Achilles tendon Total Rupture Score (ATRS), was tested for validity, structure, and internal consistency (Cronbach's alpha) on 82 patients and 52 healthy persons. A correlation analysis was performed of the ATRS with the 2 validated foot/ankle/Achilles tendon scores, the Foot and Ankle Outcome Score (FAOS) and the Swedish version of the Victorian Institute of Sports Assessment-Achilles questionnaire (VISA-A-S). Structure was evaluated with factor analysis. Test-retest reliability was evaluated on 43 patients. The ATRS responsiveness was tested on 43 patients by calculating the effect size.


RESULTS
The total score for the patients ranged from 17 to 100 with a mean (median) of 77 (85) and a standard deviation (interquartile range) of 21.4 (23). A significantly (P < .0001) higher total score was found for the healthy subjects, ranging from 94 to 100 with a mean (median) of 99.8 (100) and a standard deviation (interquartile range) of 1.1 (0). The ATRS correlated significantly (P < .01) with all subscales of the FAOS (r = 0.60-0.84) and the VISA-A-S (r = 0.78). The factor analysis gave 1 factor of importance. The internal consistency was 0.96 as measured with Cronbach's alpha. The test-retest produced an intraclass correlation coefficient of 0.98. The tests for responsiveness showed an effect size between 0.87 and 2.21.


CONCLUSION
The ATRS is a patient-reported instrument with high reliability, validity, and sensitivity for measuring outcome after treatment in patients with a total Achilles tendon rupture.


CLINICAL RELEVANCE
The ATRS is a self-administered instrument with high clinical utility, and we suggest the score for measuring the outcome, related to symptoms and physical activity, after treatment in patients with a total Achilles tendon rupture.
A Practical Algorithm for the Determination of Phase from Image and Diffraction Plane Pictures

An algorithm is presented for the rapid solution of the phase of the complete wave function whose intensity in the diffraction and imaging planes of an imaging system are known. A proof is given showing that a defined error between the estimated function and the correct function must decrease as the algorithm iterates. The problem of uniqueness is discussed and results are presented demonstrating the power of the method.
The Relationship Between Creatine and Whey Protein Supplements Consumption and Anesthesia in Rats.

BACKGROUND
Because the trend of pharmacotherapy is toward controlling diet rather than administration of drugs, in our study we examined the probable relationship between Creatine (Cr) or Whey (Wh) consumption and anesthesia (analgesia effect of ketamine). Creatine and Wh are among the most favorable supplements in the market. Whey is a protein, which is extracted from milk and is a rich source of amino acids. Creatine is an amino acid derivative that can change to ATP in the body. Both of these supplements result in Nitric Oxide (NO) retention, which is believed to be effective in N-Methyl-D-aspartate (NMDA) receptor analgesia.


OBJECTIVES
The main question of this study was whether Wh and Cr are effective on analgesic and anesthetic characteristics of ketamine and whether this is related to NO retention or amino acids' features.


MATERIALS AND METHODS
We divided 30 male Wistar rats to three (n = 10) groups; including Cr, Wh and sham (water only) groups. Each group was administered (by gavage) the supplements for an intermediate dosage during 25 days. After this period, they became anesthetized using a Ketamine-Xylazine (KX) and their time to anesthesia and analgesia, and total sleep time were recorded.


RESULTS
Data were analyzed twice using the SPSS 18 software with Analysis of Variance (ANOVA) and post hoc test; first time we expunged the rats that didn't become anesthetized and the second time we included all of the samples. There was a significant P-value (P < 0.05) for total anesthesia time in the second analysis. Bonferroni multiple comparison indicated that the difference was between Cr and Sham groups (P < 0.021).


CONCLUSIONS
The data only indicated that there might be a significant relationship between Cr consumption and total sleep time. Further studies, with rats of different gender and different dosage of supplement and anesthetics are suggested.
Picotamide, a combined inhibitor of thromboxane A2 synthase and receptor, reduces 2-year mortality in diabetics with peripheral arterial disease: the DAVID study.

AIMS
Patients with diabetes are at excessive risk of mortality and cardiovascular morbidity. Previous studies suggest that aspirin may be less effective in diabetic patients. In this multi-centre, randomized, double blind trial picotamide, a dual inhibitor of thromboxane A2 synthase and receptor, was compared with aspirin for the prevention of mortality and major cardiovascular events in diabetics with peripheral arterial disease (PAD).


METHODS AND RESULTS
A total of 1209 adults aged 40-75 years with type 2 diabetes and PAD were randomized to receive picotamide (600 mg bid) or aspirin (320 mg od) for 24 months. The cumulative incidence of the 2 years overall mortality was significantly lower amongst patients who received picotamide (3.0%) than in those who received aspirin (5.5%) with a relative risk ratio for picotamide versus aspirin of 0.55 (95% CI: 0.31-0.98%). Events were reported in 43 patients (7.1%) on picotamide and 53 (8.7%) on aspirin. The combined endpoint of mortality and morbidity had a slightly lower incidence in the picotamide group but this difference did not reach statistical significance.


CONCLUSION
Picotamide is significantly more effective than aspirin in reducing overall mortality in type 2 diabetic patients with associated PAD.
Consuming and producing linked open data: the case of OpenCourseWare

Purpose The aim of this paper is to present an initiative of application of the Linked Data principles to promote data interoperability between heterogeneous OpenCourseWare (OCW) repositories and to enhance the search and discovery of contents created and shared by the universities. Design/methodology/approach This paper is a case study of how Linked Data technologies can be applied for the enhancement of open learning contents. Findings Results presented under the umbrella of OpenCourseWare Consortium (OCWC) and OCW-Universia consortium, as the integration and access to content from different repositories OCW and the development of a query method to access these data, reveal that Linked Data would offer a solution to filter and select semantically those open educational contents, and automatically are linked to the Linked Open Data Cloud.
Exponential synchronization of Markovian jumping neural networks with partly unknown transition probabilities via stochastic sampled-data control

Exponential synchronization of Markovian jumping neural networks with partly unknown transition probabilities via stochastic sampled-data control, Neurocomputing, This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Abstract: This paper investigates the exponential synchronization for a class of delayed neu-ral networks with Markovian jumping parameters and time varying delays. The considered transition probabilities are assumed to be partially unknown. In addition, the sampling period is assumed to be time-varying that switches between two different values in a random way with given probability. Several delay-dependent synchronization criteria have been derived to guarantee the exponential stability of the error systems and the master systems are stochasti-cally synchronized with the slave systems. By introducing an improved Lyapunov-Krasovskii functional (LKF) including new triple integral terms, free-weighting matrices, partly unknown transition probabilities and combining both the convex combination technique and reciprocal convex technique, a delay-dependent exponential stability criteria is obtained in terms of linear matrix inequalities (LMIs). The information about the lower bound of the discrete time-varying delay is fully used in the LKF. Furthermore, the desired sampled-data synchronization controllers can be solved in terms of the solution to LMIs. Finally, numerical examples are provided to demonstrate the feasibility of the proposed estimation schemes from its gain matrices.
Barycentric Lagrange Interpolation

Barycentric interpolation is a variant of Lagrange polynomial interpolation that is fast and stable. It deserves to be known as the standard method of polynomial interpolation.
Branch and bound for informative path planning

We present an optimal algorithm for informative path planning (IPP), using a branch and bound method inspired by feature selection algorithms. The algorithm uses the monotonicity of the objective function to give an objective function-dependent speedup versus brute force search. We present results which suggest that when maximizing variance reduction in a Gaussian process model, the speedup is significant.
Fatigue after eccentric quadriceps femoris work produces earlier gastrocnemius and delayed quadriceps femoris activation during crossover cutting among normal athletic women

Athletic women are at greater risk of anterior cruciate ligament (ACL) injury than men. Twenty, healthy, athletic women were evaluated for the effect of preferred stance limb isokinetic quadriceps femoris and hamstring fatigue from eccentric work compared with controls on the activation onset of vastus medialis, rectus femoris, vastus lateralis, the medial hamstrings, biceps femoris, and gastrocnemius muscles. Following 3 weeks of crossover cut training, subjects were tested for fatigue effects (5 subjects/week, 3 conditions, 1 condition/day, order effect controlled) on muscle activation onsets prior to crossover cut landing heelstrike (mixed model, ANOVA, P < 0.05). Fatigue from eccentric quadriceps femoris work produced delayed vastus medialis (P = 0.03), rectus femoris (P = 0.007), and vastus lateralis (P = 0.03) activation onsets compared with control, but did not differ compared to hamstring fatigue. Neither hamstring nor quadriceps femoris fatigue produced differences (P > 0.05) in medial hamstring or biceps femoris activation onsets compared to control. Quadriceps femoris fatigue from eccentric work produced earlier gastrocnemius activation onsets (P = 0.048) than control, but did not differ for hamstring fatigue. The gastrocnemius appears to provide synergistic and compensatory dynamic knee stabilization in closed kinetic chain function during quadriceps femoris fatigue. This finding in a normal group at high risk of ACL injury while performing a maneuver with a high ACL injury risk supports gastrocnemius inclusion in knee rehabilitation and conditioning programs and suggests the need for comparative evaluations of knee injured/reconstructed subjects.