LLukas22/scidocs huggingface dataset:
"Crawling Out of the Cocoon": Patients' Experiences of a Physical Therapy Exercise Intervention in the Treatment of Major Depression.

BACKGROUND
Although the effectiveness of physical exercise for depression has been studied for many years, few studies have described patients' experiences of what exercise means to them, beyond the biological focus. Moreover, exercise as a treatment for depression is rarely explored in a physical therapy context.


OBJECTIVES
The purpose of this study was to explore a physical therapy exercise intervention, as experienced by people with major depression.


DESIGN
This study had an inductive approach and used qualitative content analysis.


METHODS
Semistructured interviews were conducted with 13 people who participated in physical therapist-guided aerobic exercise in a randomized controlled trial. All participants were diagnosed with major depression according to the Diagnostic and Statistical Manual of Mental Disorders. Data were collected and analyzed in an inductive manner using qualitative content analysis according to Graneheim and Lundman.


RESULTS
Four categories emerged: (1) struggling toward a healthy self, (2) challenging the resistance, (3) feeling alive but not euphoric, and (4) needing someone to be there for you. The participants experienced that although the exercise intervention was hard work, it enhanced the feeling of being alive and made them feel that they were doing something good for themselves. These feelings were a welcome contrast to the numbness and stagnation they experienced during depression.


LIMITATIONS
The study was conducted in Swedish primary care. Transferability of results must be viewed in relation to context.


CONCLUSIONS
Exercise in a physical therapy context can improve the patients' perception of their physical ability and create a sense of liveliness, improving their depressed state. The therapeutic relationship is essential for supporting the patient's vulnerability and ambiguity in an empathic and perceptive way.
Facial soft tissue profile following bimaxillary orthognathic surgery.

OBJECTIVE
To determine the changes in the position and area of nasal and labial soft tissues in adult skeletal Class III patients who underwent bimaxillary orthognathic surgery.


MATERIALS AND METHODS
Pretreatment (T1), preoperative (T2), and posttreatment (T3) cephalometric variables and upper-lower lip areas were measured on lateral cephalometric radiographs for 20 individuals (9 male, 11 female; mean age 21.3 years at T1, 22.4 years at T2, and 23.4 years at T3) who had maxillary advancement and mandibular setback. Analysis of variance (ANOVA) and Duncan tests were used to compare the cephalometric and area measurements at the beginning of treatment, and at presurgery and postsurgery, respectively. Paired t-tests were also performed to analyze changes within the periods.


RESULTS
The tip of the nose was affected less with the movement of the underlying skeletal structure (0.25%), while the soft tissue B point (B') moved equally with the skeletal B point. As the maxilla related variables increased due to the forward movement, the upper labial areas decreased. With the backward movement of the mandible, the middle and inferior lower labial areas increased, while the superior lower labial area decreased.


CONCLUSIONS
The results of our study suggest that the dramatic improvement in the facial profiles of the bimaxillary surgery patients is primarily related to the backward movement of the mandible and the significant reduction in the superior lower lip area.
S1 domain of the porcine epidemic diarrhea virus spike protein as a vaccine antigen

Porcine epidemic diarrhea virus (PEDV) is a highly contagious virus infecting pigs of all ages with high morbidity and mortality among newborn piglets. Currently, there is no effective vaccine available to protect the pigs from PEDV. The N-terminal subunit of spike protein (S1) is responsible for virus binding to the cellular receptor and contains a number of neutralizing antibody epitopes. Thus, we expressed and produced recombinant S1 protein to protect newborn piglets by immunization of sows. Affinity tagged PEDV S1 protein was expressed in a secretory form in yeast, insect and mammalian cells to identify the most suitable production system. Purified recombinant protein was analysed by SDS-PAGE, Western blot and deglycosylation assay. A pregnant sow was intramuscularly immunized three times with adjuvanted recombinant protein prior to farrowing. PEDV-specific immune responses in sera and colostrum of the sow and piglets were assayed by ELISA and virus neutralization assays. Piglets were challenged orally with PEDV, and clinical parameters were monitored for 6 days post-challenge. Of three eukaryotic expression systems tested (yeast, insect-cell, and mammalian), expression by HEK-293 T cells gave the highest yield of protein that was N-glycosylated and was the most appropriate candidate for vaccination. Administration of the subunit vaccine in a sow resulted in induction of S1-specific IgG and IgA that were passively transferred to the suckling piglets. Also, high virus neutralization titres were observed in the serum of the vaccinated sow and its piglets. After PEDV challenge, piglets born to the vaccinated sow exhibited less severe signs of disease and significantly lower mortality compared to the piglets of a control sow. However, there were no significant differences in diarrhea, body weight and virus shedding. Thus, vaccination with S1 subunit vaccine failed to provide complete protection to suckling piglets after challenge exposure, and further improvements are needed for the development of a subunit vaccine that fully protects against PEDV infection.
Design Space and Evaluation Challenges of Adaptive Graphical User Interfaces

68 AI MAGAZINE Adaptive graphical user interfaces (GUIs) automatically tailor the presentation of functionality to better fit an individual user’s tasks, usage patterns, and abilities. A familiar example of an adaptive interface is the Windows XP start menu, where a small set of applications from the “All Programs” submenu is replicated in the top level of the “Start” menu for easier access, saving users from navigating through multiple levels of the menu hierarchy (figure 1). The potential of adaptive interfaces to reduce visual search time, cognitive load, and motor movement is appealing, and when the adaptation is successful an adaptive interface can be faster and preferred in comparison to a nonadaptive counterpart (for example, Gajos et al. [2006], Greenberg and Witten [1985]). In practice, however, many challenges exist, and, thus far, evaluation results of adaptive interfaces have been mixed. For an adaptive interface to be successful, the benefits of correct adaptations must outweigh the costs, or usability side effects, of incorrect adaptations. Often, an adaptive mechanism designed to improve one aspect of the interaction, typically motor movement or visual search, inadvertently increases effort along another dimension, such as cognitive or perceptual load. The result is that many adaptive designs that were expected to confer a benefit along one of these dimensions have failed in practice. For example, a menu that tracks how frequently each item is used and adaptively reorders itself so that items appear in order from most to least frequently accessed should improve motor performance, but in reality this design can slow users down and reduce satisfaction because of the constantly changing layout (Mitchell and Schneiderman [1989]; for example, figure 2b). Commonly cited issues with adaptive interfaces include the lack of control the user has over the adaptive process and the difficulty that users may have in predicting what the system’s response will be to a user action (Höök 2000). User evaluation of adaptive GUIs is more complex than eval-
Interfacing neurons with carbon nanotubes: (re)engineering neuronal signaling.

Carbon nanotubes (CNTs) are cylindrically shaped nanostructures made by sheets of graphene rolled up to form hollow tubes. Owing to their unique range of thermal, electronic, and structural properties, CNTs have been rapidly developing as a technology platform for biological and medical applications, including those designed to develop novel neuro-implantable devices. Depending on their structure, CNTs combine an incredible strength with an extreme flexibility. Further, these materials exhibit physical and chemical properties which allow them to efficiently conduit electrical current in electrochemical interfaces. CNTs can be organized in scaffolds made up of small fibers or tubes with diameters similar to those of neural processes such as axons and dendrites. Recently, CNT scaffolds have been found to promote growth, differentiation, and survival of neurons and to modify their electrophysiological properties. These features make CNTs an attractive material for the design of nano-bio hybrid systems able to govern cell-specific behaviors in cultured neuronal networks. The leading scope of this short review is to highlight how nanotube scaffolds can impact on neuronal signaling ability. In particular, we will focus on the direct and specific interactions between this synthetic nanomaterial and biological cell membranes, and on the ability of CNTs to improve interfaces developed to record or to stimulate neuronal activity. CNTs hold the potential for the development of innovative nanomaterial-based neurological implants. Therefore, it is particularly relevant to improve our knowledge on the impact on neuronal performance of interfacing nerve cells with CNTs.
Implementation of the Real-Time People Counting System using Wireless Sensor Networks

In this paper, we describe an automatic people-counting system based on a wireless sensor network at a mountain area. Several people-counting systems have been proposed separately. However, these systems are not suitable to a place such as the mountain area because of a few problems. In this paper, we develop a system which can count the number of visiting people and sense environment information to protect an ecosystem of the mountain area. For people-counting in the mountain area, our system uses two photo-beam sensors, a big rechargeable power and a solar power. Our people-counting method can automatically count the number of incoming and outgoing people at a special point in real time. Moreover, the environment sensors measure environment information at the mountain area, and constitute the wireless sensor network with photo-beam sensors. To establish this system in Korea mountain, we did tests on the wireless communications range and the reliability of peoplecounting. By the testing results, we found that the developed system is suitable within 200 meters for effective wireless communications in Korea mountain. When the width of a path up a mountain is within 1.5m, the reliability of people-counting in our system is over 90%. The number of visiting people and the measured environment information are used to manage and control the mountain. Keyword: People-Counting System, Sensor, Wireless Sensor Network
Comparison of aqueous humor cytokine and chemokine levels in diabetic patients with and without retinopathy

PURPOSE
To compare the aqueous humor levels of proinflammatory and angiogenic factors of diabetic patients with and without retinopathy.


METHODS
Aqueous humor was collected at the start of cataract surgery from diabetic subjects and non-diabetic controls. The presence and severity of diabetic retinopathy were graded with fundus examination. Levels of 22 different inflammatory and angiogenic cytokines and chemokines were compared.


RESULTS
Aqueous humor samples from 47 diabetic patients (20 without retinopathy, 27 with retinopathy) and 24 non-diabetic controls were included. Interleukin (IL)-2, IL-10, IL-12, interferon-alpha (IFN-α), and tumor necrosis factor (TNF)-α were measurable in significantly fewer diabetic samples, and where measurable, were at lower levels than in non-diabetic controls. IL-6 was measurable in significantly more diabetic samples, and the median levels were significantly higher in the eyes with retinopathy than the eyes without retinopathy and the non-diabetic eyes. The vascular endothelial growth factor (VEGF) level was significantly higher in the diabetic eyes with and without retinopathy compared to the non-diabetic controls. The IL-6 level positively correlated with the monocyte chemotactic protein-1 (CCL2) and interleukin-8 (CXCL8) levels and negatively with the TNF-α level. The VEGF level negatively correlated with the IL-12 and TNF-α levels.


CONCLUSIONS
The aqueous humor cytokine profile of diabetic patients without retinopathy was similar to that of patients with diabetic retinopathy. These cytokines may be useful biomarkers for early detection and prognosis of diabetic retinopathy. Compared to diabetic patients without retinopathy, only the IL-6 and VEGF levels were significantly higher in diabetic patients with retinopathy.
A New Strategy for Heavy Metal Polluted Environments: A Review of Microbial Biosorbents

Persistent heavy metal pollution poses a major threat to all life forms in the environment due to its toxic effects. These metals are very reactive at low concentrations and can accumulate in the food web, causing severe public health concerns. Remediation using conventional physical and chemical methods is uneconomical and generates large volumes of chemical waste. Bioremediation of hazardous metals has received considerable and growing interest over the years. The use of microbial biosorbents is eco-friendly and cost effective; hence, it is an efficient alternative for the remediation of heavy metal contaminated environments. Microbes have various mechanisms of metal sequestration that hold greater metal biosorption capacities. The goal of microbial biosorption is to remove and/or recover metals and metalloids from solutions, using living or dead biomass and their components. This review discusses the sources of toxic heavy metals and describes the groups of microorganisms with biosorbent potential for heavy metal removal.
Common spider bites.

There are more than 30,000 species of spiders, most of which cannot inflict serious bites to humans because of their delicate mouthparts and impotent or prey-specific venoms. However, some spiders produce toxic venoms that can cause skin lesions, systemic illnesses, and neurotoxicity. One of the more common bites is inflicted by the widow spiders (Latrodectus species). A bite from a widow spider results in muscle spasms and rigidity starting at the bite site within 30 minutes to two hours. Another common bite is inflicted by the recluse spider (Loxosceles species). Most bites from these spiders occur early in the morning and are initially painless. These bites usually progress to ulcerating dermonecrosis at the bite site. Spider bites can be prevented by simple measures. Early species identification and specific management can prevent most serious sequelae of spider bites.
Analyzing Stock Market Movements Using News, Tweets, Stock Prices and Transactions Volume Data for APPLE (AAPL), GOOGLE (GOOG) and SONY (SNE)

Goal: Today's financial markets are of complex behavior which is the result of decisions made by many traders. Goal of this research is to calculate the relationship between financial markets stock prices, volumes, counts in financial news and tweets.
 Method: Collect the data sets for the three companies - Apple, Google and Sony
 1. Collect tweets using Twitter API written in Python and extract tweet counts only related to stocks for the above companies.
 2. Collect News data counts using News API, written in Python, only related to stocks for the above companies.
 3. Collect stocks data including Volume, Close Price, etc. for the above companies.
 Findings: We find a positive correlation between the daily number of mentions of the above companies in the Tweets, News, daily stocks close prices and daily transactions volume of a company's stock after the tweets and news are released. Our results provide measurable support for the suggestion that activities in financial markets, news and tweets are fundamentally interlinked.
Hp-β-CD-Voriconazole In Situ Gelling System for Ocular Drug Delivery: In Vitro, Stability, and Antifungal Activities Assessment

The objective of the present study was to design ophthalmic delivery systems based on polymeric carriers that undergo sol-to-gel transition upon change in temperature or in the presence of cations so as to prolong the effect of HP- β -CD Voriconazole (VCZ) in situ gelling formulations. The in situ gelling formulations of Voriconazole were prepared by using pluronic F-127 (PF-127) or with combination of pluronic F-68 (PF-68) and sodium alginate by cold method technique. The prepared formulations were evaluated for their physical appearance, drug content, gelation temperature (T gel), in vitro permeation studies, rheological properties, mucoadhesion studies, antifungal studies, and stability studies. All batches of in situ formulations had satisfactory pH ranging from 6.8 to 7.4, drug content between 95% and 100%, showing uniform distribution of drug. As the concentration of each polymeric component was increased, that is, PF-68 and sodium alginate, there was a decrease in T gel with increase in viscosity and mucoadhesive strength. The in vitro drug release decreased with increase in polymeric concentrations. The stability data concluded that all formulations showed the low degradation and maximum shelf life of 2 years. The antifungal efficiency of the selected formulation against Candida albicans and Asperigillus fumigatus confirmed that designed formulation has prolonged effect and retained its properties against fungal infection.
Gait algorithm of personal mobility vehicle for negotiating obstacles.

PURPOSE
Personal mobility vehicles (PMVs) are under active development. Most PMVs are wheel-driven, a mode of transport notable for its efficiency. However, wheeled PMVs tend to have poor mobility against negotiating obstacles. The four-wheeled vehicle RT-Mover PType 3 has been developed featuring wheeled legs capable of leg motion. This allows the PMV to overcome uneven terrains, including a step approached at an angle, which ordinary wheelchairs cannot negotiate.


METHOD
This article discusses a gait algorithm in which a leg executes the necessary leg motion when optionally presented with obstacles on a road. In order to lift a wheel off the ground and perform a leg motion, the support wheels must be moved to support points to ensure that the vehicle remains stable on three wheels. When moving towards the target support point, a wheel may encounter another obstacle, and a response method for this case is also described.


RESULTS
To assess the gait algorithm, several configurations of obstacles were used for performance tests with a passenger. The capabilities of the PMV were demonstrated through experiments.


CONCLUSION
We proposed a novel gait algorithm for our PMV and realised the proposed motion pattern for PMV-based negotiating obstacles.


IMPLICATIONS FOR REHABILITATION
Our single-seat personal mobility vehicle, RT-Mover PType 3 features wheels attached on legs capable of performing leg motion, which allows the vehicle to traverse rough terrains in urban areas. We proposed a gait algorithm for RT-Mover PType 3 consisting of a series of leg motions in response to rough terrain. With this algorithm, the vehicle can traverse not only randomly placed obstacles, but also a step approached at an oblique angle, which conventional powered wheelchairs cannot navigate. Experiments with a passenger demonstrated the effectiveness of the proposed gait algorithm, suggesting that RT-Mover PType 3 can expand the mobility and range of activities of wheelchair users.
Characterization of RuO2 nanocrystals deposited on carbon nanotubes by reactive sputtering

Abstract We report deposition and characterization of RuO 2 nanocrystals (NCs) on carbon nanotubes (CNTs) by reactive radio frequency magnetron sputtering using a Ru target. Field-emission scanning electron microscopy micrographs showed the surface morphology of the as-deposited RuO 2 varied from nanoparticle-like to tube-like NCs as the oxygen flux increased from 2 to 10 sccm. X-ray diffraction pattern confirmed the formation of pure rutile RuO 2 NCs on CNTs. The transmission electron microscopy image of RuO 2 -coated CNTs revealed that RuO 2 NCs had been deposited on the surface of the CNTs with uniform size distribution and random directions. X-ray photoelectron spectroscopy spectra indicated the coexistence of higher oxidation states of ruthenium in the as-deposited RuO 2 NCs. The red-shifts of the peak positions and broadening of linewidths of the Raman features were attributed to both the size and residual stress effects.
Lidocaine patch (5%) is no more potent than placebo in treating chronic back pain when tested in a randomised double blind placebo controlled brain imaging study

BACKGROUND
The 5% Lidocaine patch is used for treating chronic neuropathic pain conditions such as chronic back pain (CBP), diabetic neuropathy and complex regional pain syndrome, but is effective in a variable proportion of patients. Our lab has reported that this treatment reduces CBP intensity and associated brain activations when tested in an open labelled preliminary study. Notably, effectiveness of the 5% Lidocaine patch has not been tested against placebo for treating CBP. In this study, effectiveness of the 5% Lidocaine patch was compared with placebo in 30 CBP patients in a randomised double-blind study where 15 patients received 5% Lidocaine patches and the remaining patients received placebo patches. Functional MRI was used to identify brain activity for fluctuations of spontaneous pain, at baseline and at two time points after start of treatment (6 hours and 2 weeks).


RESULTS
There was no significant difference between the treatment groups in either pain intensity, sensory and affective qualities of pain or in pain related brain activation at any time point. However, 50% patients in both the Lidocaine and placebo arms reported a greater than 50% decrease in pain suggesting a marked placebo effect. When tested against an untreated CBP group at similar time points, the patch treated subjects showed significantly greater decrease in pain compared to the untreated group (n = 15).


CONCLUSIONS
These findings suggest that although the 5% Lidocaine is not better than placebo in its effectiveness for treating pain, the patch itself induces a potent placebo effect in a significant proportion of CBP patients.
Speed, Data, and Ecosystems: The Future of Software Engineering

An evaluation of recent industrial and societal trends revealed three key factors driving software engineering's future: speed, data, and ecosystems. These factors' implications have led to guidelines for companies to evolve their software engineering practices. This article is part of a special issue on the Future of Software Engineering.