LLukas22/scidocs huggingface dataset:
Auditory brainstem response morphology and analysis in very preterm neonatal intensive care unit infants.

OBJECTIVES/HYPOTHESIS
Analysis of auditory brainstem response (ABR) in very preterm infants can be difficult owing to the poor detectability of the various components of the ABR. We evaluated the ABR morphology and tried to extend the current assessment system.


STUDY DESIGN
Prospective cohort study.


METHODS
We included 28 preterm very low birth weight infants admitted to the neonatal intensive care unit of Sophia Children's Hospital. ABRs were measured between 26 and 34 weeks postconceptional age. The presence of the following ABR parameters was recorded: the ipsilateral peaks I, III and V, the contralateral peaks III and V, and the response threshold.


RESULTS
In 82% of our population, a typical "bow tie" response pattern was present as a sign of early auditory development. This bow tie pattern is the narrowest part of the response wave and is predominantly characterized by the ipsilateral negative peak III. This effect may be emphasized by the contralateral peak III. The bow tie pattern is seen approximately 0.1 milliseconds before the ipsilateral peak III. From 30 weeks postconceptional age onward, a more extensive morphologic pattern is recorded in 90% of the infants. A flow chart was designed to analyze the ABR morphology of preterm infants in an unambiguous stepwise fashion.


CONCLUSIONS
A typical bow tie pattern preceding peak III seems to be the earliest characteristic of the developing ABR morphology in preterm infants. As ABR characteristics will improve with increasing age, neonatal hearing screening should be postponed until after 34 weeks.
Intelligent process modeling and optimization of die-sinking electric discharge machining

This paper reports an intelligent approach for process modeling and optimization of electric discharge machining (EDM). Physics based process modeling using finite element method (FEM) has been integrated with the soft computing techniques like artificial neural networks (ANN) and genetic algorithm (GA) to improve prediction accuracy of the model with less dependency on the experimental data. A two-dimensional axi-symmetric numerical (FEM) model of single spark EDM process has been developed based on more realistic assumptions such as Gaussian distribution of heat flux, time and energy dependent spark radius, etc. to predict the shape of crater, material removal rate (MRR) and tool wear rate (TWR). The model is validated using the reported analytical and experimental results. A comprehensive ANN based process model is proposed to establish relation between input process conditions (current, discharge voltage, duty cycle and discharge duration) and the process responses (crater size, MRR and TWR) .The ANN model was trained, tested and tuned by using the data generated from the numerical (FEM) model. It was found to accurately predict EDM process responses for chosen process conditions. The developed ANN process model was used in conjunction with the evolutionary non-dominated sorting genetic algorithm II (NSGA-II) to select optimal process parameters for roughing and finishing operations of EDM. Experimental studies were carried out to verify the process performance for the optimum machining conditions suggested by our approach. The proposed integrated (FEM–ANN–GA) approach was found efficient and robust as the suggested optimum process parameters were found to give the expected optimum performance of the EDM process. © 2010 Elsevier B.V. All rights reserved.
Evaluation of a stair-climbing power wheelchair in 25 people with tetraplegia.

OBJECTIVE
To compare the performance of a power wheelchair with stair-climbing capability (TopChair) and a conventional power wheelchair (Storm3).


DESIGN
A single-center, open-label study.


SETTING
A physical medicine and rehabilitation hospital.


PARTICIPANTS
Patients (N=25) who required power wheelchairs because of severe impairments affecting the upper and lower limbs.


INTERVENTIONS
Indoor and outdoor driving trials with both devices. Curb-clearing and stair-climbing with TopChair.


MAIN OUTCOME MEASURES
Trial duration and Quebec User Evaluation of Satisfaction with Assistive Technology (QUEST) tool; number of failures during driving trials and ability to climb curbs and stairs.


RESULTS
All 25 participants successfully completed the outdoor and indoor trials with both wheelchairs. Although differences in times to trial completion were statistically significant, they were less than 10%. QUEST scores were significantly better with the Storm3 than the TopChair for weight (P=.001), dimension (P=.006), and effectiveness (P=.04). Of the 25 participants, 23 cleared a 20-cm curb without help, and 20 climbed up and down 6 steps. Most participants felt these specific capabilities of the TopChair--for example, curb clearing and stair climbing-were easy to use (22/25 for curb, 21/25 for stairs) and helpful (24/25 and 23/25). A few participants felt insecure (4/25 and 6/25, respectively).


CONCLUSIONS
The TopChair is a promising mobility device that enables stair and curb climbing and warrants further study.
A General Analysis of the Convergence of ADMM

We provide a new proof of the linear convergence of the alternating direction method of multipliers (ADMM) when one of the objective terms is strongly convex. Our proof is based on a framework for analyzing optimization algorithms introduced in Lessard et al. [21], reducing algorithm convergence to verifying the stability of a dynamical system. This approach generalizes a number of existing results and obviates any assumptions about specific choices of algorithm parameters. On a numerical example, we demonstrate that minimizing the derived bound on the convergence rate provides a practical approach to selecting algorithm parameters for particular ADMM instances. We complement our upper bound by constructing a nearly-matching lower bound on the worst-case rate of convergence.
Motivation and incentive preferences of community health officers in Ghana: an economic behavioral experiment approach

BACKGROUND
Health worker shortage in rural areas is one of the biggest problems of the health sector in Ghana and many developing countries. This may be due to fewer incentives and support systems available to attract and retain health workers at the rural level. This study explored the willingness of community health officers (CHOs) to accept and hold rural and community job postings in Ghana.


METHODS
A discrete choice experiment was used to estimate the motivation and incentive preferences of CHOs in Ghana. All CHOs working in three Health and Demographic Surveillance System sites in Ghana, 200 in total, were interviewed between December 2012 and January 2013. Respondents were asked to choose from choice sets of job preferences. Four mixed logit models were used for the estimation. The first model considered (a) only the main effect. The other models included interaction terms for (b) gender, (c) number of children under 5 in the household, and (d) years worked at the same community. Moreover, a choice probability simulation was performed.


RESULTS
Mixed logit analyses of the data project a shorter time frame before study leave as the most important motivation for most CHOs (β 2.03; 95 % CI 1.69 to 2.36). This is also confirmed by the largest simulated choice probability (29.1 %). The interaction effect of the number of children was significant for education allowance for children (β 0.58; 95 % CI 0.24 to 0.93), salary increase (β 0.35; 95 % CI 0.03 to 0.67), and housing provision (β 0.16; 95 % CI -0.02 to 0.60). Male CHOs had a high affinity for early opportunity to go on study leave (β 0.78; 95 % CI -0.06 to 1.62). CHOs who had worked at the same place for a long time greatly valued salary increase (β 0.28; 95 % CI 0.09 to 0.47).


CONCLUSIONS
To reduce health worker shortage in rural settings, policymakers could provide "needs-specific" motivational packages. They should include career development opportunities such as shorter period of work before study leave and financial policy in the form of salary increase to recruit and retain them.
Balanced Tidset-based Parallel FP-tree Algorithm for the Frequent Pattern Mining on Grid System

Mining frequent patterns from transaction-oriented database is an important problem. Frequent patterns are essential for generate association rules, time series, etc. Most of frequent patterns mining algorithm can be classified into two categories: generate-and-test approach (Apriori-like) and pattern growth approach (FP-tree). In recent times, many methods have been proposed for solving this problem based on FP-tree, because this approach can reduce the number of database scan. However, even for pattern growth methods, the execution time grows rapidly when the database size is getting large and the given support is small. Therefore, parallel-distributed computing is a good strategy to solve this problem. Some parallel algorithms have been proposed, but the execution time is costly when the database size is large. In this paper, we proposed an efficient parallel and distributed mining algorithm-Balanced Tidset Parallel FP-tree (BTP-tree) algorithm on grid computing system. Grid system is a heterogeneous computing environment, our proposed method can balance the loading according to the tree depth and width. In order to exchange transactions efficiently, transaction identification set (Tidset) was used to directly select transactions instead of scanning database. BTP-tree, TPFP-tree and PFP-tree were implemented and the datasets generated by IBM Quest Synthetic Data Generator are used to verify the performance of BTP-tree. The experimental results show that BTP-tree can reduce the execution time significantly and has better loading balance capability than TPFP-tree and PFP-tree.
Arm control recovery enhanced by error augmentation

Here we present results where nineteen stroke survivors with chronic hemiparesis simultaneously employed the trio of patient, therapist, and machine. Massed practice combined with error augmentation, where haptic (robotic forces) and graphic (visual display) distortions are used to enhance the feedback of error, was compared to massed practice alone. The 6-week randomized crossover design involved approximately 60 minutes of daily treatment three times per week for two weeks, followed by one week of rest, and then repeated using the alternate treatment protocol. A therapist provided a visual target using a tracking device that moved a cursor in front of the patient, who was instructed to maintain the cursor on the target. The patient, therapist, technician-operator, and rater were blinded to treatment type. Several clinical measures gauged outcomes at the beginning and end of each 2-week period and one week post training. Results showed incremental benefit across most but not all days, abrupt gains in performance, and a benefit to error augmentation training in final evaluations. This application of interactive technology may be a compelling new method for enhancing a therapist's productivity in stroke-rehabilitation.
Environmental forcings of Paleogene Southern Ocean dinoflagellate biogeography

[1] Despite warm polar climates and low meridional temperature gradients, a number of different high‐latitude plankton assemblages were, to varying extents, dominated by endemic species during most of the Paleogene. To better understand the evolution of Paleogene plankton endemism in the high southern latitudes, we investigate the spatiotemporal distribution of the fossil remains of dinoflagellates, i.e., organic‐walled cysts (dinocysts), and their response to changes in regional sea surface temperature (SST). We show that Paleocene and early Eocene (∼65–50 Ma) Southern Ocean dinocyst assemblages were largely cosmopolitan in nature but that a distinct switch from cosmopolitan‐dominated to endemic‐dominated assemblages (the so‐called “transantarctic flora”) occurred around the early‐middle Eocene boundary (∼50 Ma). The spatial distribution and relative abundance patterns of this transantarctic flora correspond well with surface water circulation patterns as reconstructed through general circulation model experiments throughout the Eocene. We quantitatively compare dinocyst assemblages with previously published TEX86– based SST reconstructions through the early and middle Eocene from a key locality in the southwest Pacific Ocean, ODP Leg 189 Site 1172 on the East Tasman Plateau. We conclude that the middle Eocene onset of the proliferation of the transantarctic flora is not linearly correlated with regional SST records and that only after the transantarctic flora became fully established later in the middle Eocene, possibly triggered by large‐scale changes in surface‐ocean nutrient availability, were abundances of endemic dinocysts modulated by regional SST variations.
Are old-old patients with major depression more likely to relapse than young-old patients during continuation treatment with escitalopram?

BACKGROUND
Escitalopram has shown efficacy and tolerability in the prevention of relapse in elderly patients with major depressive disorder (MDD). This post-hoc analysis compared time to relapse for young-old patients (n = 197) to that for old-old patients (n = 108).


METHOD
Relapse prevention: after 12-weeks open-label treatment, remitters (MADRS ≤12) were randomised to double-blind treatment with escitalopram or placebo and followed over 24-weeks. Patients were outpatients with MDD from 46 European centers aged ≥75 years (old-old) or 65-74 years of age (young-old), treated with escitalopram 10-20 mg/day. Efficacy was assessed using the Montgomery Åsberg Depression Rating Scale (MADRS).


RESULTS
After open-label escitalopram treatment, a similar proportion of young-old patients (78%) and old-old patients (72%) achieved remission. In the analysis of time to relapse based on the Cox model (proportional hazards regression), with treatment and age group as covariates, the hazard ratio was 4.4 for placebo versus escitalopram (χ(2)-test, df = 1, χ(2)= 22.5, p < 0.001), whereas the effect of age was not significant, with a hazard ratio of 1.2 for old-old versus young-old (χ(2)-test, df = 1, χ(2) = 0.41, p = 0.520). Escitalopram was well tolerated in both age groups with adverse events reported by 53.1% of young-old patients and 58.3% of old-old patients. There was no significant difference in withdrawal rates due to AEs between age groups (χ(2)-test, χ(2) = 1.669, df = 1, p = 0.196).


CONCLUSIONS
Young-old and old-old patients with MDD had comparable rates of remission after open-label escitalopram, and both age groups had much lower rates of relapse on escitalopram than on placebo.
Disparities in rheumatoid arthritis disease activity according to gross domestic product in 25 countries in the QUEST–RA database

OBJECTIVE
To analyse associations between the clinical status of patients with rheumatoid arthritis (RA) and the gross domestic product (GDP) of their resident country.


METHODS
The Quantitative Standard Monitoring of Patients with Rheumatoid Arthritis (QUEST-RA) cohort includes clinical and questionnaire data from 6004 patients who were seen in usual care at 70 rheumatology clinics in 25 countries as of April 2008, including 18 European countries. Demographic variables, clinical characteristics, RA disease activity measures, including the disease activity score in 28 joints (DAS28), and treatment-related variables were analysed according to GDP per capita, including 14 "high GDP" countries with GDP per capita greater than US$24,000 and 11 "low GDP" countries with GDP per capita less than US$11,000.


RESULTS
Disease activity DAS28 ranged between 3.1 and 6.0 among the 25 countries and was significantly associated with GDP (r = -0.78, 95% CI -0.56 to -0.90, r(2) = 61%). Disease activity levels differed substantially between "high GDP" and "low GDP" countries at much greater levels than according to whether patients were currently taking or not taking methotrexate, prednisone and/or biological agents.


CONCLUSIONS
The clinical status of patients with RA was correlated significantly with GDP among 25 mostly European countries according to all disease measures, associated only modestly with the current use of antirheumatic medications. The burden of arthritis appears substantially greater in "low GDP" than in "high GDP" countries. These findings may alert healthcare professionals and designers of health policy towards improving the clinical status of patients with RA in all countries.
Arsenic trioxide inhibits Hedgehog, Notch and stem cell properties in glioblastoma neurospheres

BACKGROUND
Notch and Hedgehog signaling have been implicated in the pathogenesis and stem-like characteristics of glioblastomas, and inhibitors of the pathways have been suggested as new therapies for these aggressive tumors. It has also been reported that targeting both pathways simultaneously can be advantageous in treating glioblastoma neurospheres, but this is difficult to achieve in vivo using multiple agents. Since arsenic trioxide has been shown to inhibit both Notch and Hedgehog in some solid tumors, we examined its effects on these pathways and on stem cell phenotype in glioblastoma.


RESULTS
We found that arsenic trioxide suppresses proliferation and promotes apoptosis in three stem-like glioblastoma neurospheres lines, while inhibiting Notch and Hedgehog target genes. Importantly, arsenic trioxide markedly reduced clonogenic capacity of the tumor neurospheres, and the stem-like CD133-positive fraction was also diminished along with expression of the stem cell markers SOX2 and CD133.


CONCLUSIONS
Our results suggest that arsenic trioxide may be effective in targeting stem-like glioblastoma cells in patients by inhibiting Notch and Hedgehog activity.
Correlates of objectively measured physical activity in obese children.

The aim of this study was to identify potential correlates of objectively measured physical activity in a sample of obese children. A cross-sectional design was used to assess 137 5-9-year-old obese children (mean +/- s.d. age = 8.3 +/- 1.1 years; mean BMI z-score = 2.76 +/- 0.70; 58% girls) from two regional cities in New South Wales, Australia, before commencement in a treatment trial. Correlates examined included age, BMI z, parental BMI, perceived competence, health-related quality of life, daily minutes spent in small screen recreation (SSR), and fundamental motor skill (FMS) proficiency. Physical activity was assessed using accelerometers and values were calculated for % of monitored time spent in moderate- (MPA) and vigorous (VPA)-intensity physical activity and mean counts per minute (CPM). Analyses were conducted separately for boys and girls. Motor skill proficiency was significantly correlated with a number of physical activity variables for boys and girls. For boys, regression analysis revealed object-control proficiency predicted CPM (R(2) = 0.25) and age was a predictor of %MPA (R(2) = 0.56). Age and object-control skill proficiency were salient predictors of %VPA (R(2) = 0.34). For girls, age and daily minutes of SSR were the only significant predictors for CPM (R(2) = 0.13). Age was the sole predictor of %MPA (R(2) = 0.38) and %VPA (R(2) = 0.15). The targeting of FMSs at an early age should be tested in experimental studies as potential strategies to increase physical activity among obese children, particularly for boys. Interventions aimed at reducing sedentary behaviors among obese girls should also be considered.
Compound lesion of a basal cell carcinoma and a malignant melanoma: Is there a common genetic origin?

A compound or collision tumor is a rare occurrence in dermatological findings [1]. The coincidence of malignant melanoma (MM) and basal cell carcinoma (BCC) within the same lesion have only been described in few cases in the literature [2–5]. However, until now the pathogenesis of collision tumors existing of MM and BCC remains unclear [2]. To our knowledge it has not been yet established whether there is a concordant genetic background or independent origin as a possible cause for the development of such a compound tumor. We, therefore, present the extremely rare case of a collision tumor of MM and BCC and the results of a genome-wide analysis by single nucleotide polymorphism array (SNP-Array) for detection of identical genomic aberrations.
A longitudinal study of supine lateral DXA of the lumbar spine: A comparison with posteroanterior spine, hip and total-body DXA

We report a study to assess whether supine lateral dual-energy X-ray absorptiometry (DXA) scans of the lumbar spine provide better data for monitoring response to treatment than alternative measurement sites such as the posteroanterior (PA) spine, hip and total body. The study population was 152 women enrolled in a placebo-controlled clinical trial of cyclical etidronate therapy. All subjects were 1–10 years after the menopause with bone mineral density (BMD) between 0 and −2 SD of age-matched normal women. Paired PA and lateral spine, left hip and total-body DXA scans were performed at baseline, 1 year and 2 years on a Hologic QDR-2000. One hundred and thirty-one subjects completed the study. Mean percentage change from baseline at 2 years in the treated (n=61) and control (n=70) groups was calculated for vertebral body, width-adjusted (WA) vertebral body, mid-vertebral body and WA mid-vertebral body BMD measurements on the lateral scans and compared with the percentage changes in PA spine, femoral neck, trochanter, Ward's triangle and total-body BMD. The long-term precision for each BMD measurement site was obtained by linear regression analysis in subjects taking placebo. Overall treatment effect, defined as the difference in the percentage change in BMD in the two treatment groups at 2 years, was divided by long-term precision to give an index of the ability of each site to monitor response to treatment. Results (and standard errors) normalized to the ratio of treatment effect/precision for PA spine BMD were as follows: PA spine, 1.00; vertebral body, 0.89 (0.14); WA vertebral body, 0.78 (0.14); mid-vertebral body, 0.65 (0.14); WA mid-vertebral body, 0.60 (0.13); femoral neck, 0.35 (0.15); trochanter, 0.45 (0.15); Ward's triangle, 0.59 (0.22); total body, 0.52 (0.19). Although treatment effect was larger for lateral than for PA spine BMD, this advantage was offset by the greater precision errors. PA spine BMD remains the optimum measurement for longitudinal studies in recently postmenopausal women.
An overview of mobile assisted language learning: From content delivery to supported collaboration and interaction

Mobile learning is undergoing rapid evolution. While early generations of mobile learning tended to propose activities that were carefully crafted by educators and technologists, learners are increasingly motivated by their personal learning needs, including those arising from greater mobility and frequent travel. At the same time, it is often argued that mobile devices are particularly suited to supporting social contacts and collaborative learning claims that have obvious relevance for language learning. A review of publications reporting mobile-assisted language learning (MALL) was undertaken to discover how far mobile devices are being used to support social contact and collaborative learning. In particular, we were interested in speaking and listening practice and in the possibilities for both synchronous and asynchronous interaction in the context of online and distance learning. We reflect on how mobile language learning has developed to date and suggest directions for the future.