LLukas22/scidocs huggingface dataset:
Association between corticosteroids and infection, sepsis, and infectious death in pediatric acute myeloid leukemia (AML): results from the Canadian infections in AML research group.

BACKGROUND
Infection continues to be a major problem for children with acute myeloid leukemia (AML). Objectives were to identify factors associated with infection, sepsis, and infectious deaths in children with newly diagnosed AML.


METHODS
We conducted a retrospective, population-based cohort study that included children ≤ 18 years of age with de novo, non-M3 AML diagnosed between January 1995 and December 2004, treated at 15 Canadian centers. Patients were monitored for infection from initiation of AML treatment until recovery from the last cycle of chemotherapy, conditioning for hematopoietic stem cell transplantation, relapse, persistent disease, or death (whichever occurred first). Consistent trained research associates abstracted all information from each site.


RESULTS
341 patients were included. Median age was 7.1 years (interquartile range [IQR], 2.0-13.5) and 29 (8.5%) had Down syndrome. In sum, 26 (7.6%) experienced death as a first event. There were 1277 courses of chemotherapy administered in which sterile site microbiologically documented infection occurred in 313 courses (24.5%). Sepsis and infectious death occurred in 97 (7.6%) and 16 (1.3%) courses, respectively. The median days of corticosteroid administration was 2 per course (IQR, 0-6). In multiple regression analysis, duration of corticosteroid exposure was significantly associated with more microbiologically documented sterile site infection, bacteremia, fungal infection, and sepsis. The only factor significantly associated with infectious death was days of corticosteroid exposure (odds ratio, 1.05; 95% confidence interval, 1.02-1.08; P = .001).


CONCLUSIONS
In pediatric AML, infection, sepsis, and infectious death were associated with duration of corticosteroid exposure. Corticosteroids should be avoided when possible for this population.
Adult attachment styles, early relationships, antenatal attachment, and perceptions of infant temperament: A study of first-time mothers

We explored the relative contributions of first-time mothers’ romantic attachment styles and early relations with their own mothers to the prediction of infant temperamental difficulty. A mediating role for mother’s attachment to the unborn baby was assumed. In a prospective longitudinal study of 115 mothers of healthy babies, a structural model was delineated according to a conception of maternally reported infant temperament as a reflection of basic aspects of the mother’s personality and mother-infant relationships. Mothers’ experiences with their own mothers as supportive and nonintrusive differentiated between securely and insecurely attached participants. Security of attachment was found to facilitate antenatal attachment and perceptions of the 4-month-old infant as easier. Findings indicate that the effects of the mothers’ romantic attachment styles on their perceptions of temperamental difficulty are mediated by their antenatal attachment. Moreover, the pattern of findings obtained suggests a link among mothers’ history of relationships, romantic attachment styles, and caregiving characteristics that is congruent with evolutionary theoretical assumptions The basic tenets of attachment theory (Bowlby, 1969,1973,1979) are that humans have a propensity toward making strong and affectionate bonds to particular others, and that the mental representations of early experiences with caregivers guide subsequent significant interpersonal relations. These assumptions have spawned a great deal of research on the attachment of inWe are very grateful to the Public Health nursing staff of the Israel Ministry of Health, Southern District, for their cooperation in making this research possible. We wish to thank the anonymous reviewers for their very helpful comments on a draft of the article and the ideas involved. This research was supported in part by the B. Steiner Family Center at the Ben-Gurion Uni-
Alvimopan accelerates gastrointestinal recovery after radical cystectomy: a multicenter randomized placebo-controlled trial.

BACKGROUND
Radical cystectomy (RC) for bladder cancer is frequently associated with delayed gastrointestinal (GI) recovery that prolongs hospital length of stay (LOS).


OBJECTIVE
To assess the efficacy of alvimopan to accelerate GI recovery after RC.


DESIGN, SETTING, AND PARTICIPANTS
We conducted a randomized double-blind placebo-controlled trial in patients undergoing RC and receiving postoperative intravenous patient-controlled opioid analgesics.


INTERVENTION
Oral alvimopan 12 mg (maximum: 15 inpatient doses) versus placebo.


OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS
The two-component primary end point was time to upper (first tolerance of solid food) and lower (first bowel movement) GI recovery (GI-2). Time to discharge order written, postoperative LOS, postoperative ileus (POI)-related morbidity, opioid consumption, and adverse events (AEs) were evaluated. An independent adjudication of cardiovascular AEs was performed.


RESULTS AND LIMITATIONS
Patients were randomized to alvimopan (n=143) or placebo (n=137); 277 patients were included in the modified intention-to-treat population. The alvimopan cohort experienced quicker GI-2 recovery (5.5 vs 6.8 d; hazard ratio: 1.8; p<0.0001), shorter mean LOS (7.4 vs 10.1 d; p=0.0051), and fewer episodes of POI-related morbidity (8.4% vs 29.1%; p<0.001). The incidence of opioid consumption and AEs or serious AEs (SAEs) was comparable except for POI, which was lower in the alvimopan group (AEs: 7% vs 26%; SAEs: 5% vs 20%, respectively). Cardiovascular AEs occurred in 8.4% (alvimopan) and 15.3% (placebo) of patients (p=0.09). Generalizability may be limited due to the exclusion of epidural analgesia and the inclusion of mostly high-volume centers utilizing open laparotomy.


CONCLUSIONS
Alvimopan is a useful addition to a standardized care pathway in patients undergoing RC by accelerating GI recovery and shortening LOS, with a safety profile similar to placebo.


PATIENT SUMMARY
This study examined the effects of alvimopan on bowel recovery in patients undergoing radical cystectomy for bladder cancer. Patients receiving alvimopan experienced quicker bowel recovery and had a shorter hospital stay compared with those who received placebo, with comparable safety.


TRIAL REGISTRATION
ClinicalTrials.gov identifier NCT00708201.
Students’ Needs, Teachers’ Support, and Motivation for Doing Homework: A Cross-Sectional Study

Self-determination theory provided the theoretical framework for a cross-sectional investigation of elementary and junior high school students’ autonomous motivation for homework. More specifically, the study focused on the role of teachers’ support of students’ psychological needs in students’ motivation for homework in the two school systems. The study also investigated the contribution of a match between teachers’ support and students’ expressed level of psychological needs to autonomous motivation for homework. The findings indicated that teacher support partially mediated the difference in autonomous motivation for homework between students in the two school systems. In addition, the findings suggested that whereas students’ with different level of expressed needs may perceive different levels of teachers’ support, and that teachers’ support might be more important for students who express higher level of needs, perceived teachers’ support of psychological needs was important for students’ adaptive motivation for homework, irrespective of their expressed level of needs.
How low does ethical leadership flow ? Test of a trickle-down model

0749-5978/$ see front matter 2008 Elsevier Inc. A doi:10.1016/j.obhdp.2008.04.002 * Corresponding author. Fax: +1 407 823 3725. E-mail address: dmayer@bus.ucf.edu (D.M. Mayer) This research examines the relationships between top management and supervisory ethical leadership and group-level outcomes (e.g., deviance, OCB) and suggests that ethical leadership flows from one organizational level to the next. Drawing on social learning theory [Bandura, A. (1977). Social learning theory. Englewood Cliffs, NJ: Prentice-Hall.; Bandura, A. (1986). Social foundations of thought and action. Englewood Cliffs, NJ: Prentice-Hall.] and social exchange theory [Blau, p. (1964). Exchange and power in social life. New York: John Wiley.], the results support our theoretical model using a sample of 904 employees and 195 managers in 195 departments. We find a direct negative relationship between both top management and supervisory ethical leadership and group-level deviance, and a positive relationship with group-level OCB. Finally, consistent with the proposed trickle-down model, the effects of top management ethical leadership on group-level deviance and OCB are mediated by supervisory ethical leadership. 2008 Elsevier Inc. All rights reserved.
Learning Global Term Weights for Content-based Recommender Systems

Recommender systems typically leverage two types of signals to effectively recommend items to users: user activities and content matching between user and item profiles, and recommendation models in literature are usually categorized into collaborative filtering models, content-based models and hybrid models. In practice, when rich profiles about users and items are available, and user activities are sparse (cold-start), effective content matching signals become much more important in the relevance of the recommendation. The de-facto method to measure similarity between two pieces of text is computing the cosine similarity of the two bags of words, and each word is weighted by TF (term frequency within the document) × IDF (inverted document frequency of the word within the corpus). In general sense, TF can represent any local weighting scheme of the word within each document, and IDF can represent any global weighting scheme of the word across the corpus. In this paper, we focus on the latter, i.e., optimizing the global term weights, for a particular recommendation domain by leveraging supervised approaches. The intuition is that some frequent words (lower IDF, e.g. “database”) can be essential and predictive for relevant recommendation, while some rare words (higher IDF, e.g. the name of a small company) could have less predictive power. Given plenty of observed activities between users and items as training data, we should be able to learn better domain-specific global term weights, which can further improve the relevance of recommendation. We propose a unified method that can simultaneously learn the weights of multiple content matching signals, as well as global term weights for specific recommendation tasks. Our method is efficient to handle large-scale training data ∗This work was conducted during an internship at LinkedIn. Copyright is held by the International World Wide Web Conference Committee (IW3C2). IW3C2 reserves the right to provide a hyperlink to the author’s site if the Material is used in electronic media. WWW 2016, April 11–15, 2016, Montréal, Québec, Canada. ACM 978-1-4503-4143-1/16/04. http://dx.doi.org/10.1145/2872427.2883069 . generated by production recommender systems. And experiments on LinkedIn job recommendation data justify the effectiveness of our approach.
Induction coil sensors—a review

The induction coil sensors (called also search coils, pickup coils or magnetic loop sensors) are described. The design methods of air coils and ferromagnetic core coils are compared and summarized. The frequency properties of the coil sensors are analyzed and various methods of output signal processing are presented. Special kinds of induction sensors, as Rogowski coil, gradiometer sensors, vibrating coil sensors, tangential field sensors and needle probes are described. The application of coil sensor as magnetic antenna is presented. Index Terms – coil sensor, magnetic field measurement, search coil, Rogowski coil, vibrating coil, gradiometer, integrator circuit, H-coil sensor, needle probe method.
The SI! Program for Cardiovascular Health Promotion in Early Childhood: A Cluster-Randomized Trial.

BACKGROUND
The preschool years offer a unique window of opportunity to instill healthy life-style behaviors and promote cardiovascular health.


OBJECTIVES
This study sought to evaluate the effect of a 3-year multidimensional school-based intervention to improve life-style-related behaviors.


METHODS
We performed a cluster-randomized controlled intervention trial involving 24 public schools in Madrid, Spain, that were assigned to either the SI! Program intervention or the usual curriculum and followed for 3 years. The SI! Program aimed to instill and develop healthy behaviors in relation to diet, physical activity, and understanding how the human body and heart work. The primary outcome was change in the overall knowledge, attitudes, and habits (KAH) score (range 0 to 80). The intervention's effect on adiposity markers was also evaluated.


RESULTS
A total of 2,062 children from 3 to 5 years of age were randomized. After 3 years of follow-up, the overall KAH score was 4.9% higher in children in the intervention group compared with the control group (21.7 vs. 16.4; p < 0.001). A peak effect was observed at the second year (improvement 7.1% higher than in the control group; p < 0.001). Physical activity was the main driver of the change in KAH at all evaluation times. Children in the intervention group for 2 years and 1 year showed greater improvement than control subjects (5.9%; p < 0.001 and 2.9%; p = 0.002, respectively). After 3 years, the intervention group showed a higher probability than the control group of reducing the triceps skinfold z-score by at least 0.1 (hazard ratio: 1.40, 95% confidence interval: 1.04 to 1.89; p = 0.027).


CONCLUSIONS
The SI! Program is an effective strategy for instilling healthy habits among preschoolers, translating into a beneficial effect on adiposity, with maximal effect when started at the earliest age and maintained over 3 years. Wider adoption may have a meaningful effect on cardiovascular health promotion. (Evaluation of the Program SI! for Preschool Education: A School-Based Randomized Controlled Trial [Preschool_PSI!]; NCT01579708).
On the Exploitation of User Personality in Recommender Systems

In this paper we revise the state of the art on personality-aware recommender systems, identifying main research trends and achievements up to date, and discussing open issues that may be addressed in the future.
A community-based feasibility study using wheat bran fiber supplementation to lower colon cancer risk.

METHODS
In this feasibility study, free-living older adults (n = 180; means = 67.5 years old) were randomly assigned to one of three levels of a 3-month standardized compliance enhancement program.


RESULTS
Regarding subject compliance with the 18 g/day wheat bran fiber supplement, the high compliance enhancement group had a superior regimen compliance rate (88%) versus the medium and low groups, (66 and 29%, respectively) (P = 0.01), with similar attrition rates.


CONCLUSION
No significant gastrointestinal side effects and changes in body weight were reported. For similar efficacy, the comprehensive compliance enhancement group had the greatest cost effectiveness.
A novel randomly textured phosphor structure for highly efficient white light-emitting diodes

We have successfully demonstrated the enhanced luminous flux and lumen efficiency in white light-emitting diodes by the randomly textured phosphor structure. The textured phosphor structure was fabricated by a simple imprinting technique, which does not need an expensive dry-etching machine or a complex patterned definition. The textured phosphor structure increases luminous flux by 5.4% and 2.5% at a driving current of 120 mA, compared with the flat phosphor and half-spherical lens structures, respectively. The increment was due to the scattering of textured surface and also the phosphor particles, leading to the enhancement of utilization efficiency of blue light. Furthermore, the textured phosphor structure has a larger view angle at the full width at half maximum (87°) than the reference LEDs.
Distributed Data Streams

DEFINITION A majority of today’s data is constantly evolving and fundam entally distributed in nature. Data for almost any large-sc ale data-management task is continuously collected over a wide area, and at a much greater rate than ever before. Compared to t aditional, centralized stream processing, querying such la rge-scale, evolving data collections poses new challenges , due mainly to the physical distribution of the streaming data and the co mmunication constraints of the underlying network. Distri buted stream processing algorithms should guarantee efficiency n ot o ly in terms ofspaceand processing time(as conventional streaming techniques), but also in terms of the communication loadimposed on the network infrastructure.
Seeds and oil of the Styrian oil pumpkin: Components and biological activities

Cucurbita pepo subsp. pepo var. Styriaca is a phylogenetically young member of the Cucurbita spp. since the mutation leading to dark green seeds with stunted outer hulls arose only in the 19th century. This mutation defined the so-called Styrian oil pumpkin and facilitated the production of Styrian pumpkin seed oil. It is a regional specialty oil in the south-eastern part of Europe. In this article, we describe the production and economic value of this edible oil as well as its composition on a molecular basis, including fatty acids, vitamins, phytosterols, minerals, polyphenols, and the compounds responsible for its pigments, taste and flavor. We also describe contaminants of Styrian pumpkin seed oil and the most relevant field pests of the Styrian oil pumpkin plant. Finally, we review the putative beneficial health effects of Styrian oil pumpkin seeds and of their products.
Histological study on the effects of microablative fractional CO2 laser on atrophic vaginal tissue: an ex vivo study.

OBJECTIVE
Microablative fractional CO2 laser has been proven to determine tissue remodeling with neoformation of collagen and elastic fibers on atrophic skin. The aim of our study is to evaluate the effects of microablative fractional CO2 laser on postmenopausal women with vulvovaginal atrophy using an ex vivo model.


METHODS
This is a prospective ex vivo cohort trial. Consecutive postmenopausal women with vulvovaginal atrophy managed with pelvic organ prolapse surgical operation were enrolled. After fascial plication, the redundant vaginal edge on one side was treated with CO2 laser (SmartXide2; DEKA Laser, Florence, Italy). Five different CO2 laser setup protocols were tested. The contralateral part of the vaginal wall was always used as control. Excessive vagina was trimmed and sent for histological evaluation to compare treated and nontreated tissues. Microscopic and ultrastructural aspects of the collagenic and elastic components of the matrix were studied, and a specific image analysis with computerized morphometry was performed. We also considered the fine cytological aspects of connective tissue proper cells, particularly fibroblasts.


RESULTS
During the study period, five women were enrolled, and 10 vaginal specimens were finally retrieved. Four different settings of CO2 laser were compared. Protocols were tested twice each to confirm histological findings. Treatment protocols were compared according to histological findings, particularly in maximal depth and connective changes achieved. All procedures were uneventful for participants.


CONCLUSIONS
This study shows that microablative fractional CO2 laser can produce a remodeling of vaginal connective tissue without causing damage to surrounding tissue.
Maternal Carriage and Antimicrobial Resistance Profile of Group B Streptococcus

Background: The aim of this study was to determine the prevalence of group B Streptococcus (GBS) colonization and to evaluate the antimicrobial resistance profile in women in the third trimester of pregnancy. Materials and Methods: A total of 310 pregnant women, referred in weeks 35 to 37 of gestation, were screened for GBS colonization during a 10-month period. Samples were collected from the vagina and the rectum. Results: The colonization rate was 10.6 % and 22 women (66.7%) had both positive vaginal and rectal cultures. Rates of GBS colonization were significantly lower in patients aged 24 years or older and in those with a third or later pregnancy. None of the isolates were resistant to penicillin and ampicillin, whereas 21.2% and 9.1% showed resistance to erythromycin and clindamycin, respectively. Conclusion: Screening and antimicrobial susceptibility testing of GBS during pregnancy are important to guide appropiate therapy.
Spotting words in handwritten Arabic documents

The design and performance of a system for spotting handwritten Arabic words in scanned document images is presented. Three main components of the system are a word segmenter, a shape based matcher for words and a search interface. The user types in a query in English within a search window, the system finds the equivalent Arabic word, e.g., by dictionary look-up, locates word images in an indexed (segmented) set of documents. A two-step approach is employed in performing the search: (1) prototype selection: the query is used to obtain a set of handwritten samples of that word from a known set of writers (these are the prototypes), and (2) word matching: the prototypes are used to spot each occurrence of those words in the indexed document database. A ranking is performed on the entire set of test word images– where the ranking criterion is a similarity score between each prototype word and the candidate words based on global word shape features. A database of 20, 000 word images contained in 100 scanned handwritten Arabic documents written by 10 different writers was used to study retrieval performance. Using five writers for providing prototypes and the other five for testing, using manually segmented documents, 55% precision is obtained at 50% recall. Performance increases as more writers are used for training.
Stem cell-based cell therapy in neurological diseases: a review.

Human neurological disorders such as Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis (ALS), Alzheimer's disease, multiple sclerosis (MS), stroke, and spinal cord injury are caused by a loss of neurons and glial cells in the brain or spinal cord. Cell replacement therapy and gene transfer to the diseased or injured brain have provided the basis for the development of potentially powerful new therapeutic strategies for a broad spectrum of human neurological diseases. However, the paucity of suitable cell types for cell replacement therapy in patients suffering from neurological disorders has hampered the development of this promising therapeutic approach. In recent years, neurons and glial cells have successfully been generated from stem cells such as embryonic stem cells, mesenchymal stem cells, and neural stem cells, and extensive efforts by investigators to develop stem cell-based brain transplantation therapies have been carried out. We review here notable experimental and preclinical studies previously published involving stem cell-based cell and gene therapies for Parkinson's disease, Huntington's disease, ALS, Alzheimer's disease, MS, stroke, spinal cord injury, brain tumor, and lysosomal storage diseases and discuss the future prospects for stem cell therapy of neurological disorders in the clinical setting. There are still many obstacles to be overcome before clinical application of cell therapy in neurological disease patients is adopted: 1) it is still uncertain what kind of stem cells would be an ideal source for cellular grafts, and 2) the mechanism by which transplantation of stem cells leads to an enhanced functional recovery and structural reorganization must to be better understood. Steady and solid progress in stem cell research in both basic and preclinical settings should support the hope for development of stem cell-based cell therapies for neurological diseases.