LLukas22/scidocs huggingface dataset:
Probability density functions of some skew tent maps

We consider a family of chaotic skew tent maps. The skew tent map is a two-parameter, piecewise-linear, weakly-unimodal, map of the interval Fa;b. We show that Fa;b is Markov for a dense set of parameters in the chaotic region, and we exactly ®nd the probability density function (pdf), for any of these maps. It is well known (Boyarsky A, G ora P. Laws of chaos: invariant measures and dynamical systems in one dimension. Boston: Birkhauser, 1997), that when a sequence of transformations has a uniform limit F, and the corresponding sequence of invariant pdfs has a weak limit, then that invariant pdf must be F invariant. However, we show in the case of a family of skew tent maps that not only does a suitable sequence of convergent sequence exist, but they can be constructed entirely within the family of skew tent maps. Furthermore, such a sequence can be found amongst the set of Markov transformations, for which pdfs are easily and exactly calculated. We then apply these results to exactly integrate Lyapunov exponents. Ó 2000 Elsevier Science Ltd. All rights reserved.
The pathogenesis and treatment of large granular lymphocyte leukemia.

Large granular lymphocyte (LGL) leukemia is a spectrum of rare lymphoproliferative diseases of T lymphocytes and natural killer cells. These diseases frequently present with splenomegaly, neutropenia, and autoimmune diseases like rheumatoid arthritis. LGL leukemia is more commonly of a chronic, indolent nature; however, rarely, they have an aggressive course. LGL leukemia is thought to arise from chronic antigen stimulation, which drives long-term cell survival through the activation of survival signaling pathways and suppression of pro-apoptotic signals. These include Jak-Stat, Mapk, Pi3k-Akt, sphingolipid, and IL-15/Pdgf signaling. Treatment traditionally includes immunosuppression with low dose methotrexate, cyclophosphamide, and other immunosuppressive agents; however, prospective and retrospective studies reveal very limited success. New studies surrounding Jak-Stat signaling suggest this may reveal new avenues for LGL leukemia therapeutics.
Endovascular edge-to-edge mitral valve repair: short-term results in a porcine model.

BACKGROUND
The edge-to-edge technique is an accepted method for the surgical repair of a regurgitant mitral valve. This study reports the initial use of an endovascular technology that enables a double-orifice edge-to-edge mitral valve repair without cardiopulmonary bypass in an animal model.


METHODS AND RESULTS
Adult pigs (n=14) were anesthetized, and left thoracotomy was performed for epicardial echo imaging. Using femoral vein access, a steerable guide catheter was placed transseptally into the left atrium. An implantable clip designed to grasp and approximate the middle scallops of the anterior and posterior mitral leaflets was introduced through the guide catheter. The clip was opened in the left atrium, advanced through the mitral orifice, and retracted to grasp the leaflet edges. When a functional double-orifice valve was confirmed by echo, the clip was closed to coapt the leaflets and detached from the delivery catheter. Before final clip detachment, echo demonstrated a double orifice in all 14 animals. In 2 studies, the clip released from the anterior mitral leaflet. Retrospective analysis of echo images indicated an incomplete grasp of the anterior leaflet. Immediate postmortem examination revealed that the clip successfully approximated the middle scallops of the anterior and posterior leaflets in all 12 double-orifice studies.


CONCLUSIONS
This study demonstrates for the first time that an endovascular system can be successfully used to perform the edge-to-edge repair technique in a nondiseased porcine model. This technique is potentially applicable as a percutaneous catheterization laboratory procedure for the treatment of mitral regurgitation in humans.
A multi-criteria hybrid citation recommendation system based on linked data

Citation recommendation systems can help a researcher find works that are relevant to his field of interest. Currently, most approaches in citation recommendation are based on a closed-world view which is limited to using a single data source for recommendation. Such a limitation decreases quality of the recommendations since no single data source contains all required information about different aspects of the literature. This paper proposes a citation recommendation approach based on the open-world view provided by the emerging web of data. It uses multiple linked data sources to create a rich background data layer, and a combination of content-based and multi-criteria collaborative filtering as the recommendation algorithm. Experiments demonstrate that the proposed approach is sound and promising.
Effects of training in minimalist shoes on the intrinsic and extrinsic foot muscle volume.

BACKGROUND
Minimalist shoes have gained popularity recently because it is speculated to strengthen the foot muscles and foot arches, which may help to resist injuries. However, previous studies provided limited evidence supporting the link between changes in muscle size and footwear transition. Therefore, this study sought to examine the effects of minimalist shoes on the intrinsic and extrinsic foot muscle volume in habitual shod runners. The relationship between participants' compliance with the minimalist shoes and changes in muscle õvolume was also evaluated.


METHODS
Twenty habitual shod runners underwent a 6-month self-monitoring training program designed for minimalist shoe transition. Another 18 characteristics-matched shod runners were also introduced with the same program but they maintained running practice with standard shoes. Runners were monitored using an online surveillance platform during the program. We measured overall intrinsic and extrinsic foot muscle volume before and after the program using MRI scans.


FINDINGS
Runners in the experimental group exhibited significantly larger leg (P=0.01, Cohen's d=0.62) and foot (P<0.01, Cohen's d=0.54) muscle after transition. Foot muscle growth was mainly contributed by the forefoot (P<0.01, Cohen's d=0.64) but not the rearfoot muscle (P=0.10, Cohen's d=0.30). Leg and foot muscle volume of runners in the control group remained similar after the program (P=0.33-0.95). A significant positive correlation was found between participants' compliance with the minimalist shoes and changes in leg muscle volume (r=0.51; P=0.02).


INTERPRETATION
Habitual shod runners who transitioned to minimalist shoes demonstrated significant increase in leg and foot muscle volume. Additionally, the increase in leg muscle volume was significantly correlated associated with the compliance of minimalist shoe use.
Building a Sentiment Summarizer for Local Service Reviews

Online user reviews are increasingly becoming the de-facto standard for measuring the quality of electronics, restaurants, merchants, etc. The sheer volume of online reviews makes it difficult for a human to process and extract all meaningful information in order to make an educated purchase. As a result, there has been a trend toward systems that can automatically summarize opinions from a set of reviews and display them in an easy to process manner [1, 9]. In this paper, we present a system that summarizes the sentiment of reviews for a local service such as a restaurant or hotel. In particular we focus on aspect-based summarization models [8], where a summary is built by extracting relevant aspects of a service, such as service or value, aggregating the sentiment per aspect, and selecting aspect-relevant text. We describe the details of both the aspect extraction and sentiment detection modules of our system. A novel aspect of these models is that they exploit user provided labels and domain specific characteristics of service reviews to increase quality.
47,XXY Klinefelter syndrome: clinical characteristics and age-specific recommendations for medical management.

47,XXY (Klinefelter syndrome) is the most frequent sex chromosomal disorder and affects approximately one in 660 newborn boys. The syndrome is characterized by varying degrees of cognitive, social, behavioral, and learning difficulties and in adulthood additionally primary testicular failure with small testes, hypergonadotropic hypogonadism, tall stature, and eunuchoid body proportions. The phenotype is variable ranging from "near-normal" to a significantly affected individual. In addition, newborns with Klinefelter syndrome generally present with a normal male phenotype and the only consistent clinical finding in KS is small testes, that are most often not identified until after puberty. Decreased awareness of this syndrome among health professionals and a general perception that all patients with 47,XXY exhibit the classic textbook phenotype results in a highly under-diagnosed condition with up to 75% of the patients left undetected. Typically, diagnosis is delayed with the majority of patients identified during fertility workup in adulthood, and only 10% of patients diagnosed prior to puberty. Early detection of this syndrome is recommended in order to offer treatment and intervention at the appropriate ages and stages of development for the purpose of preventing osteopenia/osteoporosis, metabolic syndrome, and other medical conditions related to hypogonadism and to the XXY as well as minimizing potential learning and psychosocial problems. The aim of this review is to present the clinical aspects of XXY and the age-specific recommendations for medical management. © 2013 Wiley Periodicals, Inc.
Twelve tips for facilitating Millennials' learning.

BACKGROUND
The current, so-called "Millennial" generation of learners is frequently characterized as having deep understanding of, and appreciation for, technology and social connectedness. This generation of learners has also been molded by a unique set of cultural influences that are essential for medical educators to consider in all aspects of their teaching, including curriculum design, student assessment, and interactions between faculty and learners.


AIM
 The following tips outline an approach to facilitating learning of our current generation of medical trainees.


METHOD
 The method is based on the available literature and the authors' experiences with Millennial Learners in medical training.


RESULTS
 The 12 tips provide detailed approaches and specific strategies for understanding and engaging Millennial Learners and enhancing their learning.


CONCLUSION
 With an increased understanding of the characteristics of the current generation of medical trainees, faculty will be better able to facilitate learning and optimize interactions with Millennial Learners.
Post-stabilization for rigid body simulation with contact and constraints

Rigid body dynamics with contact constraints can be solved locally using linear complementarity techniques. However, these techniques do not impose the original constraints and need stabilization. In this paper we show how constraint stabilization can also be done in a complementarity framework. Our technique effectively eliminates the drift problem for both equality and inequality constraints and requires no parameter tweaking. We describe results from an implemented system, and compare the new technique to the well known Baumgarte stabilization.
Network slicing as a service: enabling enterprises' own software-defined cellular networks

With the blossoming of network functions virtualization and software-defined networks, networks are becoming more and more agile with features like resilience, programmability, and open interfaces, which help operators to launch a network or service with more flexibility and shorter time to market. Recently, the concept of network slicing has been proposed to facilitate the building of a dedicated and customized logical network with virtualized resources. In this article, we introduce the concept of hierarchical NSaaS, helping operators to offer customized end-to-end cellular networks as a service. Moreover, the service orchestration and service level agreement mapping for quality assurance are introduced to illustrate the architecture of service management across different levels of service models. Finally, we illustrate the process of network slicing as a service within operators by typical examples. With network slicing as a service, we believe that the supporting system will transform itself to a production system by merging the operation and business domains, and enabling operators to build network slices for vertical industries more agilely.
A dose-finding study of fondaparinux in patients with non-ST-segment elevation acute coronary syndromes: the Pentasaccharide in Unstable Angina (PENTUA) Study.

OBJECTIVES
In this dose-finding study, we sought to compare fondaparinux with enoxaparin in patients with acute coronary syndromes (ACS).


BACKGROUND
Fondaparinux is a synthetic pentasaccharide that selectively inhibits activated clotting factor X. It has been demonstrated as effective in preventing thromboembolic complications in orthopedic surgery.


METHODS
Four doses fondaparinux (2.5, 4, 8, or 12 mg once daily) and enoxaparin (1 mg/kg twice daily) were compared, both given for three to seven days, in patients with ACS without persistent ST-segment elevation.


RESULTS
The rates of the combined primary end point of death, myocardial infarction, or recurrent ischemia after nine days were 27.9%, 35.9%, 34.7%, 30.3%, and 35.7% in patients allocated to fondaparinux doses of 2.5, 4, 8, and 12 mg and enoxaparin, respectively (p = NS). In the per-protocol analysis (929 patients who received adequate study drug and had adequate ST-segment monitoring), these figures were 30.0%, 43.5%, 41.0%, 34.8%, and 40.2%. Again, no dose response was observed. The lowest event rates were observed in the 2.5-mg fondaparinux group, which had significantly lower rates than the enoxaparin group as well as for 4 and 8 mg fondaparinux in the per-protocol analysis (p < 0.05). Bleeding rates were low and not different among the patient groups. No differences were observed in fondaparinux concentrations in patients with or without death, myocardial infarction, recurrent ischemia, or bleeding events.


CONCLUSIONS
This dose-finding study revealed no dose response for different fondaparinux doses ranging from 2.5 to 12 mg subcutaneously and suggests that the efficacy and safety of fondaparinux may be similar to that of enoxaparin. Further studies with fondaparinux in ACS might include the lowest dose (2.5 mg) investigated in this study.
INTRODUCTION TO INDIVIDUALS AND THE ENVIRONMENT

…organisms are functionally indivisible and cannot be split into the conventional compartments of morphology, physiology, behaviour and genetics. Each of these is only one aspect of the organism as a whole … it is the organisms which deals with physical environment.
Clinical outcome and paravalvular leakage of the new balloon-expandable Edwards Sapien 3 valve in comparison to its predecessor model (Edwards Sapien XT) in patients undergoing transfemoral aortic valve replacement.

OBJECTIVES
The aim of this study was to compare the 30-day procedural, clinical and echocardiographic outcome of the new balloon-expandable Edwards Sapien 3 (ES3) valve with the Edwards Sapien XT (ESXT).


BACKGROUND
Post-implant paravalvular leaks (PVL) after transfemoral aortic valve replacement (TAVR) resulting in residual aortic regurgitation (AR) are a major limitation for long term outcome. New TAVR-devices have to eliminate this problem.


METHODS
Transfemoral TAVR was performed in 209 consecutive intermediate-high-risk surgical patients (pts) with symptomatic aortic stenosis (ESXT n = 102, ES3 n = 107). Transthoracic echocardiography (TTE) and 3-dimensional computed tomography were used for valve size selection. Primary endpoint of the study was none/trace AR derived by TTE 30-days after TAVR.


RESULTS
All pts underwent successfully TAVR with a combined device success of 100/102 (99%) in ESXT and 107/107 (100%) in ES3 pts. Fluoroscopy time (ESXT 11.8 ± 0.5 min vs. ES3 10.0 ± 0.5 min, P = 0.003) and contrast (ESXT 188.9 ± 5.6 mL vs. ES3 170.4 ± 4.7 mL, P = 0.04) were significantly lower in ES3 patients. 30-day clinical events did not differ. Transvalvular mean pressure gradients were significantly reduced to 7.4 ± 0.8 mmHg after ESXT and to 10.1± 0.4 mmHg after ES3 implantation. After 30 days none/trace AR was found in 34.3% (n = 35) of all ESXT pts in contrast to 89.7% (n = 96) of all ES3 patients. Moderate-to-severe AR was found rarely (ESXT 2.9% vs. ES3 0%, P = 0.073).


CONCLUSIONS
Although there was no significant difference in 30 day mortality, the newer ES3 valve reduced significantly residual paravalvular leakage. © 2016 Wiley Periodicals, Inc.
Are buildings only instances?: exploration in architectural style categories

Instance retrieval has emerged as a promising research area with buildings as the popular test subject. Given a query image or region, the objective is to find images in the database containing the same object or scene. There has been a recent surge in efforts in finding instances of the same building in challenging datasets such as the Oxford 5k dataset [19], Oxford 100k dataset and the Paris dataset [20].
 We ascend one level higher and pose the question: Are Buildings Only Instances? Buildings located in the same geographical region or constructed in a certain time period in history often follow a specific method of construction. These architectural styles are characterized by certain features which distinguish them from other styles of architecture. We explore, beyond the idea of buildings as instances, the possibility that buildings can be categorized based on the architectural style. Certain characteristic features distinguish an architectural style from others. We perform experiments to evaluate how characteristic information obtained from low-level feature configurations can help in classification of buildings into architectural style categories. Encouraged by our observations, we mine characteristic features with semantic utility for different architectural styles from our dataset of European monuments. These mined features are of various scales, and provide an insight into what makes a particular architectural style category distinct. The utility of the mined characteristics is verified from Wikipedia.
Outcomes and costs associated with hospitalist comanagement of medically complex children undergoing spinal fusion surgery.

OBJECTIVE
The goal of this study was to assess outcomes and costs associated with hospitalist comanagement of medically complex children undergoing spinal fusion surgery for neuromuscular scoliosis.


METHODS
A hospitalist comanagement program was implemented at a children's hospital. We conducted a retrospective case series study of patients during 2003-2008 to compare clinical and cost outcomes for 87 preimplementation patients, 40 patients during a partially implemented program, and 80 patients during a fully implemented program.


RESULTS
When compared with preimplementation patients, full implementation program patients did not demonstrate a statistically significant difference in median length of stay on the medical/surgical unit after transfer from the PICU (median: 6 vs 8 days; P = .07). Patients in the full implementation group received fewer days of parenteral nutrition (median: 0 vs 6 days; P = .0006) and had fewer planned and unplanned laboratory studies on the inpatient unit. There was no statistically significant change in returns to the operating room (P = .08 between preimplementation and full implementation), other complications, or 30-day readmissions. Median hospital costs increased from preimplementation ($59372) to partial implementation ($89302) and remained elevated during full implementation ($81 651) compared with preimplementation (P = .004). Mean physician costs followed a similar trajectory from preimplementation ($18425) to partial implementation ($24101) to full implementation ($22578; P = .0006 [versus preimplementation]).


CONCLUSIONS
A hospitalist comanagement program can significantly affect the care of medically complex children undergoing spinal fusion surgery. Initial program costs may increase.
AMELIORATION OF FLUORIDE TOXICITY BY VITAMINS E AND D IN REPRODUCTIVE FUNCTIONS OF MALE MICE

Studies on the beneficial effects of vitamins E and D supplementation on functions of caput and cauda epididymides, their spermatozoa, vas deferens and seminal vesicle of sodium fluoride (NaF) treated (10 mg/kg body weight) male mice (Mus musculus) were carried out. The NaF treatment resulted in significant decrease in the body and epididymis weight but those of vas deferens and seminal vesicle were not affected. NaF treatment brought about alterations in epididymal milieu as elucidated by the significant decrease in levels of sialic acid and protein as well as activity of ATPase in epididymides. As a result, the sperm maturation process was affected leading to a significant decline in cauda epididymal sperm motility and viability. This caused a significant reduction in fertility rate. The cauda epididymal sperm count was also significantly reduced. The data obtained suggest that fluoride treatment induced significant metabolic alterations in the epididymides, vas deferens and seminal vesicles of mice. The withdrawal of NaF treatment (30 days) produced incomplete recovery. On the other hand, sup-plementation of vitamins E or D during the withdrawal period of NaF treated mice was found to be very beneficial in recovery of all NaF induced effects, thus elucidating their ameliorative role in recovery from toxic effects of NaF on the reproductive functions and fertility. On the whole, a combination of vitamins E and D treatment was comparatively more effective than that with vitamin E or D alone. Therefore, vitamin therapy could be beneficial for the amelioration of fluoride induced changes in reproductive functions.
Influence of dense-array EEG cap on fMRI signal.

Dense-array (>64 channel) electroencephalography (EEG) systems are increasingly being used in simultaneous EEG-functional magnetic resonance imaging (fMRI) studies. However, with increasing channel count, dense-array EEG caps can induce more severe signal dropout in the MRI images than conventional systems due to the radiofrequency shielding effect of the denser wire bundle. This study investigates the influence of a 256-channel EEG cap on MRI image quality and detection sensitivity of blood oxygen level dependent fMRI signal. A theoretical model is first established to describe the impact of the EEG cap on anatomic signal, noise, signal-to-noise ratio, and contrast-to-noise ratio of blood oxygen level dependent signal. Seven subjects were scanned to measure and compare the T(2)-weighted image quality and fMRI detection sensitivity with and without the EEG cap using an auditory/visual/sensorimotor task. The results show that the dense-array EEG cap can substantially reduce the anatomic signal in the brain areas (visual cortex) near the conducting wires (average percent decrease ≈ 38%). However, the image signal-to-noise ratio with and without the EEG cap was comparable (percent decrease < 8%, not statistically significant), and there was no statistically significant difference in the extent of blood oxygen level dependent activation. This suggests that the ability to detect fMRI signal is nearly unaffected by dense-array EEG caps in simultaneous EEG-fMRI experiments.