LLukas22/scidocs huggingface dataset:
Colorectal cancer screening in Korean workers: using a stage model approach to examine the ecological predictors of behavior.

BACKGROUND
Early detection is important for reducing mortality by colorectal cancer. Workplaces have access to a large number of people, approximately half of the Korean population. For cancer prevention, it is necessary to approach cancer screening through the workplace.


OBJECTIVE
In this cross-sectional study, we aimed to identify colorectal cancer screening (CRCS) stages and to predict factors that affect the respective stages.


METHODS
Data were collected from 314 manual workers at 32 medium-sized and small workplaces located in Korea. The dependent variable was the stage of CRCS, and independent variables were intrapersonal, interpersonal, and organizational levels.


RESULTS
At the intrapersonal level, workers who increased work hours per week or who felt stress were less likely to be in the acting/maintenance stage than in the decided to act stage of CRCS. At the organizational level, workers in medium-sized workplaces, those whose administrators secured health checkup and cancer screening budget for their workplace, and those considering health checkup and cancer screening were more likely to be in the acting/maintenance stage, compared with the decided to act stage.


CONCLUSIONS
Our findings suggest that the respective stages are affected by different intrapersonal, interpersonal, and organizational factors.


IMPLICATION FOR PRACTICE
The workplace environment and organizational predictors before the implementation of CRCS promotion programs may produce better results.
Teaching Generative Design

Generative design, which integrates multidisciplinary types of expertise in unconventional ways, was reserved just until recently to experienced and highly autodidactic designers. However, growing recognition of the importance of generative design methodologies have resulted in a need to introduce theories and applications of generative design to undergraduate students as part of their design studies. This emerging educational field of generative design teaching currently lacks methodologies, teaching experience and introductory study material. Available textbooks related to algorithmic form generation, discussing algorithmic growth, artificial life, fractal images, emergent behaviour and the like have originated in the field of mathematics. This resource provides an abundance of examples and generative approaches but when adapted to design education, it poses great interdisciplinary challenges which are addressed in this paper. Experiences in generative design teaching are presented, focusing on the relation between algorithmic reproduction of nature (as emphasized by authors in the mathematical field) and innovation (as commonly emphasized in design education). This discussion leads to a derivation of pedagogic suggestions as early steps on the way towards theories and curricula of generative design teaching, addressed to curriculum planners, generative design teachers as well as novices of the field such as undergraduate students.
A note on brane creation

The M-theory origin of brane creation processes is discussed. e-mail: dealwis@gopika.colorado.edu Recently Hanany and Witten[1] have shown how to derive non-perturbative results for (three-dimensional) field theory starting from ten-dimensional type IIB. In the course of the discussion they derived certain brane transition rules which show that when certain branes cross, other branes are created. This phenomenon has been the subject of some discussion [2],[3],[4],[5],[6]. In this paper we will discuss the M-theory origin of these transition rules. In particular the correct normalizations of various terms in the action of five and two branes coupled to M-theory obtained in [7], [8], will enable us to fix directly the relations between the charges and intersection numbers that enter into these rules. We work in eleven dimesional Planck units, i.e. we have set 2κ11 = 1 so that the M-membrane tension is T2 = (2π) 2/3 and the five-brane tension is T5 = (2π) . The action I for low-energy M theory coupled to a two-brane and a five-brane allowing also for the possibility of the two-brane ending on the five-brane is, I 2π = − 1 2 (2π) 1 3 ∫
Sodium benzoate-rich beverage consumption is associated with increased reporting of ADHD symptoms in college students: a pilot investigation.

OBJECTIVE
Sodium benzoate, a common additive in popular beverages, has recently been linked to ADHD. This research examined the relationship between sodium benzoate-rich beverage ingestion and symptoms related to ADHD in college students.


METHOD
College students (N = 475) completed an anonymous survey in class in fall 2010. The survey assessed recent intake of a noninclusive list of sodium benzoate-rich beverages and ADHD-related symptoms using a validated screener.


RESULTS
Sodium benzoate-rich beverage intake was significantly associated with ADHD-related symptoms (p = .001), and significance was retained after controlling for covariates. Students scoring ≥4 on the screener (scores that may be consistent with ADHD; n = 67) reported higher intakes (34.9 ± 4.4 servings/month) than the remainder of the sample (16.7 ± 1.1 servings/month).


CONCLUSION
These data suggest that a high intake of sodium benzoate-rich beverages may contribute to ADHD-related symptoms in college students and warrants further investigation.
A 20-year review of trends in deliberate self-harm in a British town, 1981–2000

It is important to identify trends in deliberate self-harm because of potential links both with complex mental health problems and with suicide itself, and because of its significant impact on resources in both mental health and acute health services. Patients presenting at the A&E department at Kidderminster General Hospital following an act of deliberate self-harm between the years 1981 and 2000 were assessed by the Parasuicide Counselling Group. These data were used to examine trends in deliberate self-harm and patient characteristics. The 20-year study examined 4,474 episodes of deliberate self-harm in the Kidderminster district. Rates of deliberate self-harm were higher in females throughout, although the difference between the genders narrowed in the second half of the 1990s. In both males and females, the rate of deliberate self-harm was highest in those aged 15–24. Since the mid-1990s, there have been increases in the rate of deliberate self-harm in males aged 45–54 and in females aged 25–44. Rates were highest in males and females who were separated. Although the most common method of deliberate self-harm in both males and females was overdose, males used cutting and other methods of deliberate self-harm proportionally more than females. There was a relentless rise in paracetamol use until a decline at the end of the study period following the introduction of a restriction on sales. Alcohol use at the time of deliberate self-harm rose markedly in both genders. There was a significant increase in deliberate self-harm repetition in both males and females over the study period. In males and females, psychiatric involvement or admission increased in the 1990s compared to the 1980s. Higher levels of deliberate self-harm repetition and psychiatric involvement suggest increasing pressures on health services and a continuing need to develop understanding of deliberate self-harm.
A unified data mining solution for authorship analysis in anonymous textual communications

The cyber world provides an anonymous environment for criminals to conduct malicious activities such as spamming, sending ransom e-mails, and spreading botnet malware. Often, these activities involve textual communication between a criminal and a victim, or between criminals themselves. The forensic analysis of online textual documents for addressing the anonymity problem called authorship analysis is the focus of most cybercrime investigations. Authorship analysis is the statistical study of linguistic and computational characteristics of the written documents of individuals. This paper is the first work that presents a unified data mining solution to address authorship analysis problems based on the concept of frequent pattern-based writeprint. Extensive experiments on real-life data suggest that our proposed solution can precisely capture the writing styles of individuals. Furthermore, the writeprint is effective to identify the author of an anonymous text from ∗Corresponding author Email addresses: iqbal_f@ciise.concordia.ca (Farkhund Iqbal), h_binsal@ciise.concordia.ca (Hamad Binsalleeh), fung@ciise.concordia.ca (Benjamin C. M. Fung), debbabi@ciise.concordia.ca (Mourad Debbabi) Preprint submitted to Information Sciences March 10, 2011 a group of suspects and to infer sociolinguistic characteristics of the author.
Decision support from financial disclosures with deep neural networks and transfer learning

Company disclosures greatly aid in the process of financial decision-making; therefore, they are consulted by financial investors and automated traders before exercising ownership in stocks. While humans are usually able to correctly interpret the content, the same is rarely true of computerized decision support systems, which struggle with the complexity and ambiguity of natural language. A possible remedy is represented by deep learning, which overcomes several shortcomings of traditional methods of text mining. For instance, recurrent neural networks, such as long shortterm memories, employ hierarchical structures, together with a large number of hidden layers, to automatically extract features from ordered sequences of words and capture highly non-linear relationships such as context-dependent meanings. However, deep learning has only recently started to receive traction, possibly because its performance is largely untested. Hence, this paper studies the use of deep neural networks for financial decision support. We additionally experiment with transfer learning, in which we pre-train the network on a different corpus with a length of 139.1 million words. Our results reveal a higher directional accuracy as compared to traditional machine learning when predicting stock price movements in response ∗Corresponding author. Mail: mathias.kraus@is.uni-freiburg.de; Tel: +49 761 203 2395; Fax: +49 761 203 2416. Email addresses: mathias.kraus@is.uni-freiburg.de (Mathias Kraus), sfeuerriegel@ethz.ch (Stefan Feuerriegel) Preprint submitted to Decision Support Systems July 6, 2018 ar X iv :1 71 0. 03 95 4v 1 [ cs .C L ] 1 1 O ct 2 01 7 to financial disclosures. Our work thereby helps to highlight the business value of deep learning and provides recommendations to practitioners and executives.
Clinicopathologic prognostic factors of pure myxoid liposarcoma of the extremities and trunk wall.

BACKGROUND
Myxoid liposarcoma is generally considered a low grade tumor but the presence of areas of round cells exceeding 5% is reportedly associated with a worse prognosis. Whether "pure" tumors without round cells are low grade has not been confirmed. While radiotherapy has been used for patients' myxoid liposarcoma it is unclear whether it reduces local recurrences.


QUESTIONS/PURPOSES
We therefore determined the survival, roles of radiotherapy for local control, and prognostic factors of pure myxoid liposarcoma of the extremities and trunk wall.


METHODS
We retrospectively reviewed 53 patients histologically diagnosed with pure myxoid liposarcoma arising in extremities and the trunk wall. Nine patients of the 53 received radiotherapy for primary tumors. Clinical features and prognosis was determined, and various factors were analyzed as to their usefulness as prognostic factors (age, gender, location, size, depth, surgical margin, and adjuvant radiotherapy). The minimum followup was 12 months (mean, 60 months; range, 12-226 months).


RESULTS
Seven (13%) and 6 (11%) patients developed a local recurrence and distant metastasis, respectively. The 5- and 10-year disease-specific and disease-free survival rates were 90% and 83% and 77% and 77%, respectively. Radiotherapy had no impact on either overall or disease free survival. Age (older than 60 years) independently predicted worse overall and disease-free survival.


CONCLUSIONS
In pure myxoid liposarcoma located in the extremities and trunk wall, relatively few patients developed distant metastasis suggesting the tumor is generally low grade. Local control could be achieved with wide surgical margins without radiotherapy. Age was associated with lower survival but size and depth were not. Myxoid liposarcoma in older patients requires special consideration for treatment and followup.
1,25-Dihydroxyvitamin D3 (1,25(OH)2D3) Signaling Capacity and the Epithelial-Mesenchymal Transition in Non-Small Cell Lung Cancer (NSCLC): Implications for Use of 1,25(OH)2D3 in NSCLC Treatment

1,25-dihydroxyvitamin D3 (1,25(OH)2D3) exerts anti-proliferative activity by binding to the vitamin D receptor (VDR) and regulating gene expression. We previously reported that non-small cell lung cancer (NSCLC) cells which harbor epidermal growth factor receptor (EGFR) mutations display elevated VDR expression (VDRhigh) and are vitamin D-sensitive. Conversely, those with K-ras mutations are VDRlow and vitamin D-refractory. Because EGFR mutations are found predominately in NSCLC cells with an epithelial phenotype and K-ras mutations are more common in cells with a mesenchymal phenotype, we investigated the relationship between vitamin D signaling capacity and the epithelial mesenchymal transition (EMT). Using NSCLC cell lines and publically available lung cancer cell line microarray data, we identified a relationship between VDR expression, 1,25(OH)2D3 sensitivity, and EMT phenotype. Further, we discovered that 1,25(OH)2D3 induces E-cadherin and decreases EMT-related molecules SNAIL, ZEB1, and vimentin in NSCLC cells. 1,25(OH)2D3-mediated changes in gene expression are associated with a significant decrease in cell migration and maintenance of epithelial morphology. These data indicate that 1,25(OH)2D3 opposes EMT in NSCLC cells. Because EMT is associated with increased migration, invasion, and chemoresistance, our data imply that 1,25(OH)2D3 may prevent lung cancer progression in a molecularly defined subset of NSCLC patients.
A national multicenter phase 2 study of prostate-specific antigen (PSA) pox virus vaccine with sequential androgen ablation therapy in patients with PSA progression: ECOG 9802.

BACKGROUND
E9802 was a phase 2 multi-institution study conducted to evaluate the safety and effectiveness of vaccinia and fowlpox prostate-specific antigen (PSA) vaccine (step 1) followed by combination with androgen ablation therapy (step 2) in patients with PSA progression without visible metastasis.


OBJECTIVE
To test the hypothesis that vaccine therapy in this early disease setting will be safe and have a biochemical effect that would support future studies of immunotherapy in patients with minimal disease burden.


DESIGN, SETTING, AND PARTICIPANTS
Patients who had PSA progression following local therapy were treated with PROSTVAC-V (vaccinia)/TRICOM on cycle 1 followed by PROSTVAC-F (fowlpox)/TRICOM for subsequent cycles in combination with granulocyte-macrophage colony-stimulating factor (step 1). Androgen ablation was added on progression (step 2).


OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS
Step 1 primary end points included progression at 6 mo and characterization of change in PSA velocity pretreatment to post-treatment. Step 2 end points included PSA response with combined vaccine and androgen ablation.


RESULTS AND LIMITATIONS
In step 1, 25 of 40 eligible patients (63%) were progression free at 6 mo after registration (90% confidence interval [CI], 48-75). The median pretreatment PSA velocity was 0.13 log(PSA)/mo, in contrast to median postregistration velocity of 0.09 log(PSA)/mo (p=0.02), which is an increase in median PSA doubling time from 5.3 mo to 7.7 mo. No grade ≥4 treatment-related toxicity was observed. In the 27 patients eligible and treated for step 2, 20 patients achieved a complete response (CR) at 7 mo (CR rate: 74%; 90% CI, 57-87). Although supportive of larger studies in the cooperative group setting, this study is limited by the small number of patients and the absence of a control group as in a phase 3 study.


CONCLUSIONS
A viral PSA vaccine can be administered safely in the multi-institutional cooperative group setting to patients with minimal disease volume alone and combined with androgen ablation, supporting the feasibility of future phase 3 studies in this population.


PATIENT SUMMARY
These data support consideration of vaccine therapy earlier in the course of prostate cancer progression with minimal disease burden in future studies of vaccine approaches in earlier stages of disease.
A Sum of Gcd ’ s over Friable Numbers

We study the function g(n, y) := i≤n P (i)≤y gcd(i, n), where P (n) denotes the largest prime factor of n, and we derive some estimates for its summatory function.
Early prevention of antisocial personality: long-term follow-up of two randomized controlled trials comparing indicated and selective approaches.

OBJECTIVE
Antisocial personality is a common adult problem that imposes a major public health burden, but for which there is no effective treatment. Affected individuals exhibit persistent antisocial behavior and pervasive antisocial character traits, such as irritability, manipulativeness, and lack of remorse. Prevention of antisocial personality in childhood has been advocated, but evidence for effective interventions is lacking.


METHOD
The authors conducted two follow-up studies of randomized trials of group parent training. One involved 120 clinic-referred 3- to 7-year-olds with severe antisocial behavior for whom treatment was indicated, 93 of whom were reassessed between ages 10 and 17. The other involved 109 high-risk 4- to 6-year-olds with elevated antisocial behavior who were selectively screened from the community, 90 of whom were reassessed between ages 9 and 13. The primary psychiatric outcome measures were the two elements of antisocial personality, namely, antisocial behavior (assessed by a diagnostic interview) and antisocial character traits (assessed by a questionnaire). Also assessed were reading achievement (an important domain of youth functioning at work) and parent-adolescent relationship quality.


RESULTS
In the indicated sample, both elements of antisocial personality were improved in the early intervention group at long-term follow-up compared with the control group (antisocial behavior: odds ratio of oppositional defiant disorder=0.20, 95% CI=0.06, 0.69; antisocial character traits: B=-4.41, 95% CI=-1.12, -8.64). Additionally, reading ability improved (B=9.18, 95% CI=0.58, 18.0). Parental expressed emotion was warmer (B=0.86, 95% CI=0.20, 1.41) and supervision was closer (B=-0.43, 95% CI=-0.11, -0.75), but direct observation of parenting showed no differences. Teacher-rated and self-rated antisocial behavior were unchanged. In contrast, in the selective high-risk sample, early intervention was not associated with improved long-term outcomes.


CONCLUSIONS
Early intervention with severely antisocial children for whom treatment is indicated may prevent the development of antisocial personality in adolescence and may improve academic performance. In contrast, early intervention with selective high-risk samples may be ineffective.
Lesotho's Minimum PMTCT Package: lessons learned for combating vertical HIV transmission using co-packaged medicines

INTRODUCTION
Mother-to-child transmission of HIV can be reduced to<5% with appropriate antiretroviral medications. Such reductions depend on multiple health system encounters during antenatal care (ANC), delivery and breastfeeding; in countries with limited access to care, transmission remains high. In Lesotho, where 28% of women attending ANC are HIV positive but where geographic and other factors limit access to ANC and facility deliveries, a Minimum PMTCT Package was launched in 2007 as an alternative to the existing facility-based approach. Distributed at the first ANC visit, it packaged together all necessary pregnancy, delivery and early postnatal antiretroviral medications for mother and infant.


METHODS
To examine the availability, feasibility, acceptability and possible negative consequences of the Minimum PMTCT Package, data from a 2009 qualitative and quantitative study and a 2010 facility assessment were used. To examine the effects on ANC and facility-based delivery rates, a difference-in-differences analytic approach was applied to 2009 Demographic and Health Survey data for HIV-tested women who gave birth before and after Minimum PMTCT Package implementation.


RESULTS
The Minimum PMTCT Package was feasible and acceptable to providers and clients. Problems with test kit and medicine stock-outs occurred, and 46% of women did not receive the Minimum PMTCT Package until at least their second ANC visit. Providing adequate instruction on the use of multiple medications represented a challenge. The proportion of HIV-positive women delivering in facilities declined after Minimum PMTCT Package implementation, although it increased among HIV-negative women (difference-in-differences=14.5%, p=0.05). The mean number of ANC visits declined more among HIV-positive women than among HIV-negative women after implementation, though the difference was not statistically significant (p=0.09). Changes in the percentage of women receiving≥4 ANC visits did not differ between the two groups.


CONCLUSIONS
If supply issues can be resolved and adequate client educational materials provided, take-away co-packages have the potential to increase access to PMTCT commodities in countries where women have limited access to health services. However, efforts must be made to carefully monitor potential changes in ANC visits and facility deliveries, and further evaluation of adherence, safety and effectiveness are needed.
Comparative Study of Automated Testing Tools: Selenium, Quick Test Professional and Testcomplete

Software testing provides a means to reduce errors, cut maintenance and overall software costs. Testing has become most important parameter in the case of software development lifecycle (SDLC). Testing automation tools enables developers and testers to easily automate the entire process of testing in software development. It is to examine & modify source code. Effective Testing produces high quality software. The objective of the paper is to conduct a comparative study of automated tools such as available in market in Selenium free source, HP Quick test professional (QTP) and TestComplete (TC). The aim of this research paper is to evaluate and compare three automated software testing tools to determine their usability and effectiveness. There is wide variety of software testing tools available in market. Software testing tools has major features likes: web testing, window application etc.