LLukas22/scidocs huggingface dataset:
Latent Semantic Analysis Parameters for Essay Evaluation using Small-Scale Corpora

Some previous studies (e.g. that carried out by Van Bruggen et al. in 2004) have pointed to a need for additional research in order to firmly establish the usefulness of LSA (latent semantic analysis) parameters for automatic evaluation of academic essays. The extreme variability in approaches to this technique makes it difficult to identify the most efficient parameters and the optimum combination. With this goal in mind, we conducted a high spectrum study to investigate the efficiency of some of the major LSA parameters in small-scale corpora. We used two specific domain corpora that differed in the structure of the text (one containing only technical terms and the other with more tangential information). Using these corpora we tested different semantic spaces, formed by applying different parameters and different methods of comparing the texts. Parameters varied included weighting functions (Log-IDF or Log-Entropy), dimensionality reduction (truncating the matrices after SVD to a set percentage of dimensions), methods of forming pseudo-documents (vector sum and folding-in) and measures of similarity (cosine or Euclidean distances). We also included two groups of essays to be graded, one written by experts and other by non-experts. Both groups were evaluated by three human graders and also by LSA. We extracted the correlations of each LSA condition with human graders, and conducted an ANOVA to analyse which parameter combination correlates best. Results suggest that distances are more efficient in academic essay evaluation than cosines. We found no clear evidence that the classical LSA protocol works systematically better than some simpler version (the classical protocol achieves the best performance only for some combinations of parameters in a few cases), and found that the benefits of reducing dimensionality arise only when the essays are introduced into semantic spaces using the folding-in method. *Address correspondence to: José Antonio León, Dpto. de Psicologı́a Básica, Facultad de Psicologı́a, Universidad Autónoma de Madrid, Campus de Cantoblanco, 28049 Madrid, Spain. Tel.: 0034 914975226. Fax: 0034 914975215. E-mail: joseantonio.leon@uam.es Journal of Quantitative Linguistics 2010, Volume 17, Number 1, pp. 1–29 DOI: 10.1080/09296170903395890 0929-6174/10/17010001 2010 Taylor & Francis
Layered Neural Networks with Gaussian Hidden Units as Universal Approximations

A neural network with a single layer of hidden units of gaussian type is proved to be a universal approximator for real-valued maps defined on convex, compact sets of Rn.
Differential apoptosis markers in human keloids and hypertrophic scars fibroblasts

Keloids are benign skin tumors and are the effect of a dysregulated wound-healing process in genetically predisposed patients. They are characterized by formation of excess scar tissue beyond the boundaries of the wound. Keloids are often confused with hypertrophic scars because of an apparent lack of morphologic differences. The molecular distinction between scars and keloid is still controversial and, until today, there is no appropriate treatment yet for keloid disease. In this study, we have found, for the first time, p53 mutations in both hypertrophic scar and keloids fibroblasts from cultured cells to various extents. Since p53 plays a central role in the DNA damage response by inducing cell cycle arrest and/or apoptotic cell death, we also set up time course experiments making cell cultures at different times to investigate the phenomenon of apoptosis and its involvement in the process of pathological scarring in both hypertrophic scars and keloids. The extent of apoptosis in this study was investigated by DNA fragmentation and MTT assays, propidium iodide staining, p53 expression, and subcellular distribution. Moreover, the correlation of apoptosis and ROS levels in keloid and hypertrophic scars fibroblasts was assessed. Understanding the molecular mechanisms that determine the regulation of apoptosis during wound healing might allow us to therapeutically modulate these pathways so that apoptotic cell death is reactivated in dysregulated and hypertrophic cells.
The temporalized Massey's method

We propose and throughly investigate a temporalized version of the popular Massey’s technique for rating actors in sport competitions. The method can be described as a dynamic temporal process in which team ratings are updated at every match according to their performance during the match and the strength of the opponent team. Using the Italian soccer dataset, we empirically show that the method has a good foresight prediction accuracy.
Automatic impedance matching for 13.56 MHz NFC antennas

This paper deals with the concept, the implementation and the verification of an automatic impedance matching circuit for NFC antennas with a frequency of 13.56 MHz. Besides an introduction to manual tuning and its issues, the fundamental components of an automatic tuning system are outlined. A lab-scaled prototype is built and demonstrated. In the end, the successful operation of this system is tested with several different antennas.
Promoting Connectedness through Whole-School Approaches: A Qualitative Study.

Purpose: School connectedness, or a sense of belonging to the school environment, is an established protective factor for child and adolescent health, education, and social well-being. While a comprehensive, whole-school approach that addresses the school organisational environment is increasingly endorsed as an effective approach to promote connectedness, how this approach creates a sense of belonging in the school environment requires systematic in-depth exploration. This paper aims to address these issues. Design/methodology/approach: This study examines the influence on school connectedness of a whole-school approach to promote health in school, using a qualitative case study method. Three school communities in southeast Queensland, Australia, were investigated as case studies in order to formulate a theoretical model of how health promotion approaches can build school connectedness. Findings: This study found that a health promotion approach builds school connectedness by encouraging a ‘whole-school’ orientation designed to foster interaction among members of the entire school community. Specific activities that promoted interaction were school-wide activities involving the entire school community and, at the classroom level, ‘whole-class’ activities in which students and staff worked together on activities that created links between the two groups, such as collaborative curriculum planning. The ‘whole-school’ emphasis on partnerships
Overall Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma.

BACKGROUND
Nivolumab combined with ipilimumab resulted in longer progression-free survival and a higher objective response rate than ipilimumab alone in a phase 3 trial involving patients with advanced melanoma. We now report 3-year overall survival outcomes in this trial.


METHODS
We randomly assigned, in a 1:1:1 ratio, patients with previously untreated advanced melanoma to receive nivolumab at a dose of 1 mg per kilogram of body weight plus ipilimumab at a dose of 3 mg per kilogram every 3 weeks for four doses, followed by nivolumab at a dose of 3 mg per kilogram every 2 weeks; nivolumab at a dose of 3 mg per kilogram every 2 weeks plus placebo; or ipilimumab at a dose of 3 mg per kilogram every 3 weeks for four doses plus placebo, until progression, the occurrence of unacceptable toxic effects, or withdrawal of consent. Randomization was stratified according to programmed death ligand 1 (PD-L1) status, BRAF mutation status, and metastasis stage. The two primary end points were progression-free survival and overall survival in the nivolumab-plus-ipilimumab group and in the nivolumab group versus the ipilimumab group.


RESULTS
At a minimum follow-up of 36 months, the median overall survival had not been reached in the nivolumab-plus-ipilimumab group and was 37.6 months in the nivolumab group, as compared with 19.9 months in the ipilimumab group (hazard ratio for death with nivolumab plus ipilimumab vs. ipilimumab, 0.55 [P<0.001]; hazard ratio for death with nivolumab vs. ipilimumab, 0.65 [P<0.001]). The overall survival rate at 3 years was 58% in the nivolumab-plus-ipilimumab group and 52% in the nivolumab group, as compared with 34% in the ipilimumab group. The safety profile was unchanged from the initial report. Treatment-related adverse events of grade 3 or 4 occurred in 59% of the patients in the nivolumab-plus-ipilimumab group, in 21% of those in the nivolumab group, and in 28% of those in the ipilimumab group.


CONCLUSIONS
Among patients with advanced melanoma, significantly longer overall survival occurred with combination therapy with nivolumab plus ipilimumab or with nivolumab alone than with ipilimumab alone. (Funded by Bristol-Myers Squibb and others; CheckMate 067 ClinicalTrials.gov number, NCT01844505 .).
Why the analyst needs to change: Toward a theory of conflict, negotiation, and mutual influence in the therapeutic process

Why the analyst needs to change: Toward a theory of conflict, negotiation, and mutual influence in the therapeutic process Malcolm Owen Slavin Ph.D. a b & Daniel Kriegman Ph.D. c a President of the Massachusetts Institute for Psychoanalysis, 112 Lakeview Avenue, Cambridge, MA, 02138 E-mail: b Director of Training, Tufts University Counseling Center c faculty member of the Massachusetts Institute for Psychoanalysis, 112 Lakeview Avenue, Cambridge, MA, 02138 Published online: 02 Nov 2009.
Could Hyaluronic acid (HA) reduce Bacillus Calmette-Guérin (BCG) local side effects? Results of a pilot study

BACKGROUND
Bacillus Calmette-Guérin (BCG) is considered the most effective treatment to reduce recurrence and progression of non-muscle invasive bladder cancer (NMIBC) but can induce local side effects leading to treatment discontinuation or interruption. Aim of this exploratory study is to investigate if the sequential administration of Hyaluronic acid (HA) may reduce local side effects of BCG.


METHODS
30 consecutive subjects undergoing BCG intravesical administration for high risk NMIBC were randomized to receive BCG only (Group A) or BCG and HA (Group B). A 1 to 10 Visual Analog Scale (VAS) for bladder pain, International Prostate Symptom Score (IPSS) and number of micturitions per day were evaluated in the two groups before and after six weekly BCG instillations. Patients were also evaluated at 3 and 6 months by means of cystostopy and urine cytology.


RESULTS
One out of 30 (3,3%) patients in group A dropped out from the protocol, for local side effects. Mean VAS for pain was significantly lower in group B after BCG treatment (4.2 vs. 5.8, p = 0.04). Post vs. pre treatment differences in VAS for pain, IPSS and number of daily micturitions were all significantly lower in group B. Three patients in group A and 4 in group B presented with recurrent pathology at 6 month follow up.


CONCLUSIONS
These preliminary data suggest a possible role of HA in reducing BCG local side effects and could be used to design larger randomized controlled trials, assessing safety and efficacy of sequential BCG and HA administration.


TRIAL REGISTRATION
NCT02207608 (ClinicalTrials.gov) 01/08/2014. Policlinico Tor Vergata Ethics Committee, resolution n 69-2011.
Men in nursing on television: exposing and reinforcing stereotypes.

AIMS
To describe the results of a study of images of men in nursing on television.


BACKGROUND
Previous research has highlighted stereotypical images around nursing, such as the battle-axe, naughty nurse and handmaiden. More recent research focuses on images of nurses who are men, because of the growing numbers of men in the nursing workforce. Given that negative images can harm recruitment and retention in the profession, it is important to interrogate how men in nursing are portrayed in popular culture. Representations on television are particularly critical to explore because of the medium's wide audience.


DESIGN
Qualitative study.


METHODS
Five American medical television programmes appearing between 2007 and 2010 were analysed for their construction of men in nursing: Grey's Anatomy, Hawthorne, Mercy, Nurse Jackie and Private Practice.


FINDINGS
Men in nursing on television were portrayed in ways that engaged with explicit and implicit stereotypes. The men were often subject to questions about their choice of career, masculinity and sexuality and their role usually reduced to that of prop, minority spokesperson or source of comedy. Thus, rather contradictorily, although the programmes often sought to expose common stereotypes about men in nursing, they nonetheless often reinforced stereotypes in more implicit ways.


CONCLUSION
This research has implications for better understanding not only the status of nursing in our society but also for nursing practice and education and attracting more men to the profession.
Enzalutamide in European and North American men participating in the AFFIRM trial

OBJECTIVE
To explore any differences in efficacy and safety outcomes between European (EU) (n = 684) and North American (NA) (n = 395) patients in the AFFIRM trial (NCT00974311).


PATIENTS AND METHODS
Phase III, double-blind, placebo-controlled, multinational AFFIRM trial in men with metastatic castration-resistant prostate cancer (mCRPC) after docetaxel. Participants were randomly assigned in a 2:1 ratio to receive oral enzalutamide 160 mg/day or placebo. The primary end point was overall survival (OS) in a post hoc analysis.


RESULTS
Enzalutamide significantly improved OS compared with placebo in both EU and NA patients. The median OS in EU patients was longer than NA patients in both treatment groups. However, the relative treatment effect, expressed as hazard ratio and 95% confidence interval, was similar in both regions: 0.64 (0.50, 0.82) for EU and 0.63 (0.47, 0.83) for NA. Significant improvements in other end points further confirmed the benefit of enzalutamide over placebo in patients from both regions. The tolerability profile of enzalutamide was comparable between EU and NA patients, with fatigue and nausea the most common adverse events. Four EU patients (4/461 enzalutamide-treated, 0.87%) and one NA patient (1/263 enzalutamide-treated, 0.38%) had seizures. The difference in median OS was related in part to the timing of development of mCRPC and baseline demographics on study entry.


CONCLUSION
This post hoc exploratory analysis of the AFFIRM trial showed a consistent OS benefit for enzalutamide in men with mCRPC who had previously progressed on docetaxel in both NA- and EU-treated patients, although the median OS was higher in EU relative to NA patients. Efficacy benefits were consistent across end points, with a comparable safety profile in both regions.
Comparison of the clinical characteristics and treatment outcomes of patients requiring hospital admission to treat eosinophilic and neutrophilic exacerbations of COPD

PURPOSE
We compared the clinical characteristics and treatment outcomes of patients with eosinophilic and neutrophilic COPD exacerbations requiring hospital admission.


PATIENTS AND METHODS
This was a retrospective multicenter study performed between January 2010 and December 2014. In all, 1,688 COPD patients admitted via the outpatient clinics or emergency departments of six university hospitals were enrolled. The patients were grouped by complete blood counts: eosinophilic group, >2% peripheral blood eosinophils, and neutrophilic group, >65% peripheral blood neutrophils or >11,000 leukocytes/mL. The patients with radiographic evidence of pneumonia at the time of admission, those with lung cancer, those admitted for treatment of other medical problems, and those who chronically used steroids were excluded.


RESULTS
A total of 605 patients hospitalized with COPD exacerbations (177 eosinophilic and 380 neutrophilic) were included. Pulmonary functions, including the forced expiratory volume in 1 second and forced vital capacity, were better in patients with eosinophilic exacerbations. Treatment outcomes, including the rate of admission to the intensive care unit and mortality, were poorer in patients with neutrophilic exacerbations (4.5% vs 12.4%, P=0.004; 1.1% vs 4.5%, P=0.043, respectively). Congestive heart failure (odds ratio [OR] =3.40, 95% confidence interval [CI]: 1.28-9.01) and neutrophilic exacerbation (OR = 2.81, 95% CI: 1.21-6.52) were independent risk factors for intensive care unit admission.


CONCLUSION
COPD patients with neutrophilic exacerbations experienced worse clinical outcomes than did those with eosinophilic exacerbations. The peripheral blood eosinophil count may be a useful predictor of clinical progress during hospitalization of COPD patients with acute exacerbations.
Performance analysis of BSTs in system software

Binary search tree (BST) based data structures, such as AVL trees, red-black trees, and splay trees, are often used in system software, such as operating system kernels. Choosing the right kind of tree can impact performance significantly, but the literature offers few empirical studies for guidance. We compare 20 BST variants using three experiments in real-world scenarios with real and artificial workloads. The results indicate that when input is expected to be randomly ordered with occasional runs of sorted order, red-black trees are preferred; when insertions often occur in sorted order, AVL trees excel for later random access, whereas splay trees perform best for later sequential or clustered access. For node representations, use of parent pointers is shown to be the fastest choice, with threaded nodes a close second choice that saves memory; nodes without parent pointers or threads suffer when traversal and modification are combined; maintaining a in-order doubly linked list is advantageous when traversal is very common; and right-threaded nodes perform poorly.
Echocardiographic predictors of an adverse response to a nifedipine trial in primary pulmonary hypertension: diminished left ventricular size and leftward ventricular septal bowing.

BACKGROUND
The clinical course in primary pulmonary hypertension (PPH) is improved by calcium channel blocker therapy in those with a favorable hemodynamic response during a trial of high-dose oral nifedipine. Although trials of nifedipine are performed only in patients who demonstrate pulmonary vasodilator reserve to short-acting agents, this response does not predict the safety of nifedipine treatment, which can result in severe first-dose hypotension and death.


STUDY OBJECTIVES
To identify echocardiographic parameters that predict first-dose nifedipine-induced hypotension in patients with PPH.


METHODS
The pretrial echocardiograms of 23 consecutive PPH patients (mean age, 42.3 +/- 13 years; 77% female) undergoing evaluation of pulmonary vasodilator reserve with nifedipine were analyzed. Patients were classified as those who suffered first-dose nifedipine hypotension (group 1) and those who did not (group 2). Echocardiographic measures of chamber size and septal geometry in the two groups were compared.


RESULTS
Five measures reflecting diminished left ventricular (LV) size and leftward ventricular septal bowing were found to be associated with nifedipine hypotension: LV transverse diameter in systole (LVDs; p = 0.007), LV transverse diameter in diastole (LVDd; p = 0.05), LV area in systole (LVAs; p = 0.009), LV area in diastole (LVAd; p = 0.03), the ratio of RV to LVAs (p = 0. 02), and leftward ventricular septal bowing (p = 0.01). The LV dimensions found to best predict nifedipine-induced hypotension were LVDs < 2.7 cm, LVDd < 4.0 cm, LVAs < 15.5 cm(2), and LVAd < 20.0 cm(2).


CONCLUSIONS
Readily available echocardiographic parameters in patients with PPH are predictive of nifedipine-induced hypotension, and can be used to select patients in whom a trial of nifedipine should be avoided.
Hierarchical Embeddings for Hypernymy Detection and Directionality

EXPERIMENTAL SETTINGS • ENCOW14A corpus ≈14.5 billion tokens. • Baseline: default SGNS (word2vec). • 100 dimensions, window 5, negative samples:15, learning rate 0.025. • Learn HyperVec for nouns and verbs. SUPERVISED CLASSIFICATION • SVM classifier based on four components: conc. + diff. + cos + magnitude(hyper) Models BLESS ENTAILMENT Yu et al. (2015) 0.90 0.87 Tuan et al. (2016) 0.93 0.91 HyperVec 0.94 0.91
The effect of atropine on rhythm and conduction disturbances during 322 critical care intubations.

OBJECTIVES
Our objectives were to describe the prevalence of arrhythmia and conduction abnormalities before critical care intubation and to test the hypothesis that atropine had no effect on their prevalence during intubation.


DESIGN
Prospective, observational study.


SETTING
PICU and pediatric/neonatal intensive care transport.


SUBJECTS
All children of age less than 8 years intubated September 2007-2009. Subgroups of intubations with and without atropine were analyzed.


INTERVENTION
None.


MEASUREMENT AND MAIN RESULTS
A total of 414 intubations were performed in the study period of which 327 were available for analysis (79%). Five children (1.5%) had arrhythmias prior to intubation and were excluded from the atropine analysis. Atropine was used in 47% (152/322) of intubations and resulted in significant acceleration of heart rate without provoking ventricular arrhythmias. New arrhythmias during intubation were related to bradycardia and were less common with atropine use (odds ratio, 0.14 [95% CI, 0.06-0.35], p < 0.001). The most common new arrhythmia was junctional rhythm. Acute bundle branch block was observed during three intubations; one Mobitz type 2 rhythm and five ventricular escape rhythms occurred in the no-atropine group (n = 170). Only one ventricular escape rhythm occurred in the atropine group (n = 152) in a child with an abnormal heart. One child died during intubation who had not received atropine.


CONCLUSIONS
Atropine significantly reduced the prevalence of new arrhythmias during intubation particularly for children over 1 month of age, did not convert sinus tachycardia to ventricular tachycardia or fibrillation, and may contribute to the safety of intubation.
Azhary: An Arabic Lexical Ontology

Arabic language is the most spoken languages in the Semitic languages group, and one of the most common languages in the world spoken by more than 422 million. It is also of paramount importance to Muslims, it is a sacred language of the Islamic Holly Book (Quran) and prayer (and other acts of worship) in Islam is performed only by mastering some of Arabic words. Arabic is also a major ritual language of a number of Christian churches in the Arab world and it is also used in writing several intellectual and religious Jewish books in the Middle Ages. Despite this, there is no semantic Arabic lexicon which researchers can depend on. In this paper we introduce Azhary as a lexical ontology for the Arabic language. It groups Arabic words into sets of synonyms called synsets, and records a number of relationships between words such as synonym, antonym, hypernym, hyponym, meronym, holonym and association relations. The ontology contains 26,195 words organized in 13,328 synsets. It has been developed and contrasted against AWN which is the most common available Arabic lexical ontology. keywords: Arabic Language, Ontology, WordNet, Semantic Web, Arabic Lexicon.