LLukas22/scidocs huggingface dataset:
Rationale of the BREAst cancer e-healTH [BREATH] multicentre randomised controlled trial: An Internet-based self-management intervention to foster adjustment after curative breast cancer by decreasing distress and increasing empowerment

After completion of curative breast cancer treatment, patients go through a transition from patient to survivor. During this re-entry phase, patients are faced with a broad range of re-entry topics, concerning physical and emotional recovery, returning to work and fear of recurrence. Standard and easy-accessible care to facilitate this transition is lacking. In order to facilitate adjustment for all breast cancer patients after primary treatment, the BREATH intervention is aimed at 1) decreasing psychological distress, and 2) increasing empowerment, defined as patients’ intra- and interpersonal strengths. The non-guided Internet-based self-management intervention is based on cognitive behavioural therapy techniques and covers four phases of recovery after breast cancer (Looking back; Emotional processing; Strengthening; Looking ahead). Each phase of the fully automated intervention has a fixed structure that targets consecutively psychoeducation, problems in everyday life, social environment, and empowerment. Working ingredients include Information (25 scripts), Assignment (48 tasks), Assessment (10 tests) and Video (39 clips extracted from recorded interviews). A non-blinded, multicentre randomised controlled, parallel-group, superiority trial will be conducted to evaluate the effectiveness of the BREATH intervention. In six hospitals in the Netherlands, a consecutive sample of 170 will be recruited of women who completed primary curative treatment for breast cancer within 4 months. Participants will be randomly allocated to receive either usual care or usual care plus access to the online BREATH intervention (1:1). Changes in self-report questionnaires from baseline to 4 (post-intervention), 6 and 10 months will be measured. The BREATH intervention provides a psychological self-management approach to the disease management of breast cancer survivors. Innovative is the use of patients’ own strengths as an explicit intervention target, which is hypothesized to serve as a buffer to prevent psychological distress in long-term survivorship. In case of proven (cost) effectiveness, the BREATH intervention can serve as a low-cost and easy-accessible intervention to facilitate emotional, physical and social recovery of all breast cancer survivors. This study is registered at the Netherlands Trial Register (NTR2935)
DASX: Hardware Accelerator for Software Data Structures

Recent research [3,37,38] has proposed compute accelerators to address the energy efficiency challenge. While these compute accelerators specialize and improve the compute efficiency, they have tended to rely on address-based load/store memory interfaces that closely resemble a traditional processor core. The address-based load/store interface is particularly challenging in data-centric applications that tend to access different software data structures. While accelerators optimize the compute section, the address-based interface leads to wasteful instructions and low memory level parallelism (MLP). We study the benefits of raising the abstraction of the memory interface to data structures.
 We propose DASX (Data Structure Accelerator), a specialized state machine for data fetch that enables compute accelerators to efficiently access data structure elements in iterative program regions. DASX enables the compute accelerators to employ data structure based memory operations and relieves the compute unit from having to generate addresses for each individual object. DASX exploits knowledge of the program's iteration to i) run ahead of the compute units and gather data objects for the compute unit (i.e., compute unit memory operations do not encounter cache misses) and ii) throttle the fetch rate, adaptively tile the dataset based on the locality characteristics and guarantee cache residency. We demonstrate accelerators for three types of data structures, Vector, Key-Value (Hash) maps, and BTrees. We demonstrate the benefits of DASX on data-centric applications which have varied compute kernels but access few regular data structures. DASX achieves higher energy efficiency by eliminating data structure instructions and enabling energy efficient compute accelerators to efficiently access the data elements. We demonstrate that DASX can achieve 4.4x the performance of a multicore system by discovering more parallelism from the data structure.
Feature-oriented programming and the AHEAD tool suite

Feature Oriented Programming (FOP) is an emerging paradigmfor application synthesis, analysis, and optimization. Atarget application is specified declaratively as a set of features,like many consumer products (e.g., personal computers,automobiles). FOP technology translates suchdeclarative specifications into efficient programs.
Identification of biomarkers to improve diagnostic sensitivity of sporadic colorectal cancer in patients with low preoperative serum carcinoembryonic antigen by clinical proteomic analysis.

BACKGROUND
Colorectal cancer (CRC) is the third most common type of cancer worldwide. Carcinoembryonic antigen (CEA) assays usually give false negative results. To improve the diagnosis of primary sporadic CRC, there is an urgent need to identify new biomarkers.


METHODS
We used laser pressure catapulting and proteomics to analyze overexpressed cancer associated proteins from 48 sporadic CRC patients with low preoperative serum CEA (LPSC) (<5 ng/ml). Real-time Q-PCR was used to identify the target gene transcripts. Immunoblots were carried out to validate the biomarkers.


RESULTS
Alpha-enolase, HSP27 and macrophage migration inhibitory factor (MIF) were overexpressed in all tumor tissues from 48 LPSC CRC patients, as assessed by 2DE image analysis. The genes were also overexpressed at the transcript level in all tumor tissues from the same patients. In the immunoblot assay, only serum levels of Alpha-enolase and MIF were significantly overexpressed in the LPSC group compared to the mean levels in the control group. Combined with the determinations of preoperative CEA levels, screening for serum Alpha-enolase and MIF were shown to improve the diagnosis of primary CRC.


CONCLUSIONS
Serum Alpha-enolase and MIF may be potential biomarkers that can be used to improve clinical predication of primary CRC with LPSC.
Twelve tips for facilitating team-based learning

BACKGROUND
Team-based learning (TBL) has become a more commonly recognized and implemented pedagogical approach in curricula of numerous disciplines. The desire to place more autonomy on the student and spend less in-class time delivering content has resulted in complete or partial adoption of this style of learning in many educational settings.


AIM
Provide faculty with tools that foster a well facilitated and interactive TBL learning environment.


METHODS
We examined the published literature in the area of facilitation - specifically in TBL environments, and explored learning theories associated with team learning and our own experiences to create these facilitation tips.


RESULTS
We created 12 tips for TBL facilitation designed to assist faculty to achieve an effective and engaging TBL learning environment.


CONCLUSIONS
Applying these twelve tips while facilitating a TBL classroom session will help to ensure maximal participation and optimal learning in a safe yet stimulating environment.
An Application of the Goldwasser-Micali Cryptosystem to Biometric Authentication

Issuer Delisting; Order Granting the Application of General Motors Corporation to Withdraw its Common Stock, $1 2/3 par value, from Listing and Registration on the Chicago Stock Exchange, Inc. File No. 1-00043 April 4, 2006 On March 2, 2006, General Motors Corporation, a Delaware corporation ("Issuer"), filed an application with the Securities and Exchange Commission ("Commission"), pursuant to Section 12(d) of the Securities Exchange Act of 1934 ("Act") and Rule 12d2-2(d) thereunder, to withdraw its common stock, $1 2/3 par value ("Security"), from listing and registration on the Chicago Stock Exchange, Inc. ("CHX"). Notice of such application requesting comments was published in the Federal Register on March 10, 2006. No comments were received. As discussed below, the Commission is granting the application. The Administrative Committee of the Issuer's Board of Directors ("Board") approved a resolution on September 9, 2005, to delist the Security from listing and registration on CHX. The Issuer stated that the purposes for seeking to delist the Security from CHX are to avoid dual regulatory oversight and dual listing fees. The Security is traded, and will continue to trade, on the New York Stock Exchange ("NYSE"). In addition, the Issuer stated that CHX advised the Issuer that the Security will continue to trade on CHX under unlisted trading privileges. The Issuer stated in its application that it has complied with applicable rules of CHX by providing CHX with the required documents governing the withdrawal of securities from listing and registration on CHX. The Issuer's application relates solely to the
Profiling and modeling of dc nitrogen microplasmas

This article explores electric current and field distributions in dc microplasmas, which have distinctive characteristics that are not evident at larger dimensions. These microplasmas, which are powered by coplanar thin-film metal electrodes with 400mm minimum separations on a glass substrate, are potentially useful for microsystems in both sensing and microfabrication contexts. Experiments in N2 ambient show that electron current favors electrode separations of 4 mm at 1.2 Torr, reducing to 0.4 mm at 10 Torr. The glow region is confined directly above the cathode, and within 200–500mm of its lateral edge. Voltage gradients of 100 kV/m exist in this glow region at 1.2 Torr, increasing to 500 kV/m at 6 Torr, far in excess of those observed in larger plasmas. Numerical simulations indicate that the microplasmas are highly nonquasineutral, with a large ion density proximate to the cathode, responsible for a dense space-charge region, and the strong electric fields in the glow region. It is responsible for the bulk of the ionization and has a bimodal electron energy distribution function, with a local peak at 420 eV. © 2003 American Institute of Physics. @DOI: 10.1063/1.1595143 #
A Force-Directed Method for Large Crossing Angle Graph Drawing

Recent empirical research has indicated that human graph reading performance improves when crossing angles increase. However, crossing angle has not been used as an aesthetic criterion for graph drawing algorithms so far. In this paper, we introduce a force-directed method that aims to construct graph drawings with large crossing angles. Experiments indicate that our method significantly increases crossing angles. Surprisingly, the experimental results further demonstrate that the resulting drawings produced by our method have fewer edge crossings, a shorter total edge length and more uniform edge lengths, compared to classical spring algorithms.
Approximation Algorithms for Facility Location Problems (Extended Abstract)

Approximationalgorithmsfor facilitylocationproblems
Localized in vivo genotypic and phenotypic correction of the albino mutation in skin by RNA-DNA oligonucleotide

We recently demonstrated that an RNA-DNA oligonucleotide corrected a point mutation in the mouse tyrosinase gene, resulting in permanent and inheritable restoration of tyrosinase enzymatic activity, melanin synthesis, and pigmentation changes in cultured melanocytes. In this study, we extended gene correction of melanocytes from tissue culture to live animals, using a chimeric oligonucleotide designed to correct a point mutation in the tyrosinase gene. Both topical application and intradermal injection of this oligonucleotide to albino BALB/c mouse skin resulted in dark pigmentation of several hairs in a localized area. The restored tyrosinase enzymatic activity was detected by dihydroxyphenylacetic acid (DOPA) staining of hair follicles in the treated skin. Tyrosinase gene correction was also confirmed by restriction fragment length polymorphism analysis and DNA sequencing from skin that was positive for DOPA staining and melanin synthesis. Localized gene correction was maintained three months after the last application of the chimeric oligonucleotides. These results demonstrated correction of the tyrosinase gene point mutation by chimeric oligonucleotides in vivo.
Lysis of the orbicularis retaining ligament and orbicularis oculi insertion: a powerful modality for lower eyelid and cheek rejuvenation.

BACKGROUND
The techniques of lower blepharoplasty are evolving to reflect the concept that the lower eyelid contour does not stop at the inferior orbital rim, and that the lid-cheek junction must often be modified to restore the midface to a youthful configuration. Multiple procedures have been proposed to smooth the lid-cheek junction and tear trough. The author proposes a technique of carbon dioxide laser lysis of the orbicularis retaining ligament and of the orbicularis oculi insertion onto the maxilla to release the tethering of the lower lid and cheek and allow recontouring of the lid-cheek junction in an extended transcutaneous lower blepharoplasty.


METHODS
Retrospective review of 80 extended lower blepharoplasty procedures with carbon dioxide laser lysis of the orbicularis retaining ligament and of the orbicularis oculi insertion performed in the past 3 years was undertaken. Follow-up ranged from 4 to 26 months, with an average of 7.2 months. The efficacy, risks, and complications of this procedure were assessed.


RESULTS
The complication rate for this procedure is not significantly higher than that for standard transcutaneous blepharoplasty, and the procedure allows significant improvement of the lid-cheek junction and rejuvenation of the upper midface.


CONCLUSIONS
Lysis of the orbicularis retaining ligament and lower orbicularis oculi insertion is a safe and effective adjunct to lower blepharoplasty. It is a powerful modality that allows significant rejuvenation of the lid-cheek complex and upper cheek.


CLINICAL QUESTION/LEVEL OF EVIDENCE
Therapeutic, IV.
On the efficient use of mathematics in economics: results of an attitude survey of British economists

Abstract The use of mathematics in Economics has grown significantly over the post-war period. Little research effort has been expended in evaluating professional attitudes to this growth. Given the importance of mathematics in economic research and in economist's training, the issue warrants consideration. This paper investigates the attitude of British economists to the use of mathematics in economics. It reports the results of a survey of academic economists in British Universities and contrasts the results with those of a similar exercise in the United States.
Evaluating the process of a genetic algorithm to improve the back-propagation network: A Monte Carlo study

Many studies have mapped a bit-string genotype using a genetic algorithm to represent network architectures to improve performance of back-propagation networks (BPN). But the limitations of gradient search techniques applied to complex nonlinear optimization problems have often resulted in inconsistent and unpredictable performance. This study focuses on how to collect and re-evaluate the weight matrices of a BPN while the genetic algorithm operations are processing in each generation to optimize the weight matrices. In this way, overfitting, a drawback of BPNs that usually occurs during the later stage of neural network training with descending training error and ascending prediction error, can also be avoided. This study extends the parameters and topology of the neural network to enhance the feasibility of the solution space for complex nonlinear problems. The value of the proposed model is compared with previous studies using a Monte Carlo study on in-sample, interpolation, and extrapolation data for six test functions. 2007 Elsevier Ltd. All rights reserved.
Association of body weight with sexual function in women

Sexual difficulties in women appear to be widespread in society; the relationship between female sexual function and obesity is unclear. This study aimed to investigate the relationship between body weight, the distribution of body fat and sexual function in women. Fifty-two, otherwise healthy women with abnormal values of female sexual function index (FSFI) score (⩽23) were compared with 66 control women (FSFI >23), matched for age and menopausal status. All women were free from diseases known to affect sexual function. FSFI strongly correlated with body mass index (BMI) (r=–0.72, P=0.0001), but not with waist-to-hip ratio (r=–0.09, P=0.48), in women with sexual dysfunction. Of the six sexual function parameters, desire and pain did not correlate with BMI, while arousal (r=–0.75), lubrication (r=–0.66), orgasm (r=–0.56) and satisfaction (r=–0.56, all P<0.001) did. FSFI score was significantly lower in overweight women as compared with normal weight women, while cholesterol and triglyceride levels were higher. On multivariate analysis, both age and BMI explained about 68% of FSFI variance, with a primacy of BMI over age (ratio 4:1). In conclusion, obesity affects several aspects of sexuality in otherwise healthy women with sexual dysfunction.
Trends of power semiconductor wafer level packaging

A review of recent advances in power wafer level electronic packaging is presented based on the development of power device integration. The paper covers in more detail how advances in both semiconductor content and power advanced wafer level package design and materials have co-enabled significant advances in power device capability during recent years. Extrapolating the same trends in representative areas for the remainder of the decade serves to highlight where further improvement in materials and techniques can drive continued enhancements in usability, efficiency, reliability and overall cost of power semiconductor solutions. Along with next generation wafer level power packaging development, the role of modeling is a key to assure successful package design. An overview of the power package modeling is presented. Challenges of wafer level power semiconductor packaging and modeling in both next generation design and assembly processes are presented and discussed. 2009 Elsevier Ltd. All rights reserved.
Aristotelian and Rogerian Rhetoric.

One of our most influential composition texts is Rhetoric: Discovery and Change. In it, Young, Becker, and Pike distinguish between classical and contemporary "domains of rhetoric"; in accordance with this distinction they differentiate Aristotle from Carl Rogers. In her article, "Aristotelian vs. Rogerian Argument: A Reassessment" (CCC, May 1979), Andrea Lunsford disputed the validity of the distinction, virtually "baptizing" Aristotle as a Rogers of his time. However, upon closer examination, Young, Becker, and Pike's perception of differences between Aristotle and Rogers can be confirmed. Furthermore, there is justifiable reason for maintaining Young, Becker, and Pike's distinction as a service to our students who need help in sensing when it is appropriate to confront "opponents" and when it is more advantageous to strive for change through mutual acceptance and understanding by each party of the other's views. The classical tradition in rhetoric, developed by Aristotle and modified by the Roman rhetoricians Cicero and Quintilian, was designed for use chiefly in law courts, political meetings, and religious ceremonies. The underlying principle of Aristotle's Rhetoric is that man is a rational animal, capable of using logical reasoning as the basis for argument.2 The strategy Artistotle uses to analyze rhetorical transactions is focussed, therefore, on the processes of logical reasoning-rational men using reasonable means (enthymemes) in exhorting or dissuading (deliberative oratory), in praising or blaming (epideictic oratory), and in accusing or defending (forensic oratory). The Rogerian strategy is based upon a different set of conditions and assumptions. Since Rogers is writing primarily from the context of patientclient therapy, his communication theory is applicable especially to rhetorical transactions outside of the advocacy situation. Young, Becker, and Pike, the principal proponents of a Rogerian-based rhetoric, point out that the Rogerian strategy "rests on the assumption that a man holds to his beliefs about who he is and what the world is like because other beliefs threaten his iden-
New Q waves on the presenting electrocardiogram independently predict increased cardiac mortality following a first ST-elevation myocardial infarction.

AIMS
The prognostic significance of pathological Q waves appearing in the acute phase of myocardial infarction has not been determined. We investigated whether new Q waves on the presenting electrocardiogram of patients with acute ST-segment elevation were independently associated with a worse outcome after a first myocardial infarction.


METHODS AND RESULTS
The presence or absence of new Q waves on the presenting electrocardiogram was assessed in 481 patients who presented within 4 h of symptom onset and were randomized to receive either captopril or placebo within 2 h of streptokinase therapy for myocardial infarction. Ventriculography was performed at 22+/-6 days and mortality status was obtained at a median follow-up of 5.6 years. New Q waves were associated with a lower ejection fraction (51+/-13% vs 61+/-12%, P<0.0001), a larger end-systolic volume index (37 ml vs 28 ml, P<0.001), and increased cardiac mortality at 30 days (7% vs 2%, P=0.01) and at follow-up (17% vs 7%, P=0.002). On multivariate analysis, age (P<0.01), new Q waves at presentation (P<0.01) and a history of angina (P=0.046) were independent predictors of cardiac mortality, whereas randomization to captopril and the time from symptom onset to streptokinase administration were not.


CONCLUSION
New Q waves at presentation are independently associated with a worse outcome after a first myocardial infarction. The presence of new Q waves on the presenting electrocardiogram allows very early identification of patients at risk of increased cardiac mortality.
Seamless outdoor/indoor navigation with WIFI/GPS aided low cost Inertial Navigation System

This paper describes an integrated navigation system that can be used for pedestrian navigation in both outdoor and indoor environments. With the aid of Global Positioning System (GPS) positioning solutions, an Inertial Navigation System (INS) can provide stable and continuous outdoor navigation. When moving indoors, WIFI positioning can replace the GPS in order to maintain the integrated system’s long-term reliability and stability. On the other hand, the position from an INS can also provide apriori information to aid WIFI positioning. Signal strength-based WIFI positioning is widely used for indoor navigation. A new fingerprinting method is proposed so as to improve the performance of WIFI stand-alone positioning. For pedestrian navigation applications, a step detection method is implemented to constrain the growth of the INS error using an Extend Kalman Filter (EKF). Experiments have been conducted to test this system and the results have demonstrated the feasibility of this seamless outdoor/indoor navigation system.