LLukas22/scidocs huggingface dataset:
A Pilot Study of Antidepressant-Induced Mania in Pediatric Bipolar Disorder: Characteristics, Risk Factors, and the Serotonin Transporter Gene

BACKGROUND
Antidepressant-induced mania (AIM) has been described in bipolar disorder (BD) and has been associated with the short-allele of the serotonin transporter gene (5-HTT). We wished to investigate the frequency of and risk factors for AIM in pediatric patients with or at high risk for BD.


METHODS
Fifty-two children and adolescents (30 with BD and 22 with subthreshold manic symptoms, 15.1 +/- 3.4 years old), all with a parent with BD, were interviewed with their parents for manic/depressive symptoms occurring before and after past antidepressant treatment. The 47 subjects with serotonin reuptake inhibitor (SSRI) exposure were genotyped for the 5-HTT polymorphism.


RESULTS
Fifty percent of subjects were AIM+ and 25.5% had new onset of suicidal ideation. The AIM+ and AIM- groups did not differ significantly in relation to allele (p = .36) or genotype (p = .53) frequencies of the 5-HTT polymorphism. The AIM+ subjects were more likely to have more comorbidities (3.2 vs. 2.4; p = .02) and be BD type I (p = .04) than AIM- subjects.


CONCLUSIONS
Youth with or at high risk for BD may be particularly vulnerable to SSRI AIM and thus should be monitored if given SSRIs. In this preliminary study, we did not find that the 5-HTT polymorphism significantly influenced vulnerability to AIM.
Lower eyelid position after transconjunctival lower blepharoplasty with versus without a skin pinch.

PURPOSE
To evaluate the effect of transconjunctival lower blepharoplasty with or without a skin pinch on lower eyelid position.


METHODS
Retrospective analysis of patients undergoing bilateral lower blepharoplasty using a transconjunctival approach with or without a skin pinch. Patients undergoing other surgical procedures that could affect lower eyelid position were excluded. Twenty-five patients (50 eyes) underwent transconjunctival blepharoplasty without skin pinch and 20 patients (40 eyes) underwent transconjunctival blepharoplasty with a skin-pinch technique. Preoperative and postoperative photographs were measured for the horizontal corneal diameter and distance from light reflex to lower eyelid margin (MRD2). The ratio of MRD2 to corneal diameter was multiplied by 11 to standardize to a corneal diameter of 11 mm. Student t test was used for statistical analysis.


RESULTS
There were 8 male and 37 female patients. Average follow-up was 4 months. Mean preoperative standardized MRD2 was 4.68 mm and 4.65 mm for transconjunctival blepharoplasty without and with skin pinch, respectively. Mean postoperative standardized MRD2 was 4.73 mm and 4.70 mm for transconjunctival blepharoplasty without and with skin pinch, respectively. The mean change in lower eyelid position was 0.05 mm after each technique. The change in lower eyelid position was not statistically significant for either group (p > 0.5). There was no significant difference in lower eyelid position change between the 2 groups (p > 0.99).


CONCLUSIONS
Transconjunctival lower blepharoplasty with or without a skin pinch yields a stable postoperative lower eyelid position.
Magnetic sensors and their applications

Magnetic sensors can be classified according to whether they measure the total magnetic field or the vector components of the magnetic field. The techniques used to produce both types of magnetic sensors encompass many aspects of physics and electronics. Here, we describe and compare most of the common technologies used for magnetic field sensing. These include search coil, fluxgate, optically pumped, nuclear precession, SQUID, Hall-effect, anisotropic magnetoresistance, giant magnetoresistance, magnetic tunnel junctions, giant magnetoimpedance, magnetostrictive/piezoelectric composites, magnetodiode, magnetotransistor, fiber optic, magnetooptic, and microelectromechanical systems-based magnetic sensors. The usage of these sensors in relation to working with or around Earth's magnetic field is also presented
Cognitive enhancing effects of modafinil in healthy volunteers

Abstract Rationale. Modafinil, a novel wake-promoting agent, has been shown to have a similar clinical profile to that of conventional stimulants such as methylphenidate. We were therefore interested in assessing whether modafinil, with its unique pharmacological mode of action, might offer similar potential as a cognitive enhancer, without the side effects commonly experienced with amphetamine-like drugs. Objectives. The main aim of this study was to evaluate the cognitive enhancing potential of this novel agent using a comprehensive battery of neuropsychological tests. Methods. Sixty healthy young adult male volunteers received either a single oral dose of placebo, or 100 mg or 200 mg modafinil prior to performing a variety of tasks designed to test memory and attention. A randomised double-blind, between-subjects design was used. Results. Modafinil significantly enhanced performance on tests of digit span, visual pattern recognition memory, spatial planning and stop-signal reaction time. These performance improvements were complemented by a slowing in latency on three tests: delayed matching to sample, a decision-making task and the spatial planning task. Subjects reported feeling more alert, attentive and energetic on drug. The effects were not clearly dose dependent, except for those seen with the stop-signal paradigm. In contrast to previous findings with methylphenidate, there were no significant effects of drug on spatial memory span, spatial working memory, rapid visual information processing or attentional set-shifting. Additionally, no effects on paired associates learning were identified. Conclusions. These data indicate that modafinil selectively improves neuropsychological task performance. This improvement may be attributable to an enhanced ability to inhibit pre-potent responses. This effect appears to reduce impulsive responding, suggesting that modafinil may be of benefit in the treatment of attention deficit hyperactivity disorder.
Smart Environment as a Service: Three Factor Cloud Based User Authentication for Telecare Medical Information System

The Telecare Medical Information System (TMIS) provides a set of different medical services to the patient and medical practitioner. The patients and medical practitioners can easily connect to the services remotely from their own premises. There are several studies carried out to enhance and authenticate smartcard-based remote user authentication protocols for TMIS system. In this article, we propose a set of enhanced and authentic Three Factor (3FA) remote user authentication protocols utilizing a smartphone capability over a dynamic Cloud Computing (CC) environment. A user can access the TMIS services presented in the form of CC services using his smart device e.g. smartphone. Our framework transforms a smartphone to act as a unique and only identity required to access the TMIS system remotely. Methods, Protocols and Authentication techniques are proposed followed by security analysis and a performance analysis with the two recent authentication protocols proposed for the healthcare TMIS system.
Crystallization behavior of CoSb3 and (Co,Fe)Sb3 thin films

Abstract The crystallization behavior of CoSb 3 and Fe-doped (Co,Fe)Sb 3 thin films prepared by d.c.-magnetron sputtering was studied via ex situ and in situ X-ray diffraction (XRD) measurements. The as-deposited layers are amorphous. Crystallization takes place at temperatures of approximately 160±16 °C. Decomposition occurs in the temperature ranges of 575–610 °C for CoSb 3 and of 640–670 °C for (Co,Fe)Sb 3 . The decomposition products are CoSb and (Co,Fe)Sb, respectively. Both ex situ XRD measurements on annealed layers and in situ measurements on as-deposited samples show a rare dependence of the cubic lattice parameter of the skutterudite type structure on the temperature. Electron probe microanalysis investigations indicate that the composition varies from Co–Sb 1:4 at low temperatures to Co–Sb 1:3 after heating cycles.
Denitrification in aquaculture systems : an example of a fuzzy logic control problem

Nitrification in commercial aquaculture systems has been accomplished using many different technologies (e.g. trickling filters, fluidized beds and rotating biological contactors) but commercial aquaculture systems have been slow to adopt denitrification. Denitrification (conversion of nitrate, NO3 − to nitrogen gas, N2) is essential to the development of commercial, closed, recirculating aquaculture systems (B1 water turnover 100 day). The problems associated with manually operated denitrification systems have been incomplete denitrification (oxidation–reduction potential, ORP\−200 mV) with the production of nitrite (NO2 ), nitric oxide (NO) and nitrous oxide (N2O) or over-reduction (ORPB−400 mV), resulting in the production of hydrogen sulfide (H2S). The need for an anoxic or anaerobic environment for the denitrifying bacteria can also result in lowered dissolved oxygen (DO) concentrations in the rearing tanks. These problems have now been overcome by the development of a computer automated denitrifying bioreactor specifically designed for aquaculture. The prototype bioreactor (process control version) has been in operation for 4 years and commercial versions of the bioreactor are now in continuous use; these bioreactors can be operated in either batch or continuous on-line modes, maintaining NO3 − concentrations below 5 ppm. The bioreactor monitors DO, ORP, pH and water flow rate and controls water pump rate and carbon feed rate. A fuzzy logic-based expert system replaced the classical process control system for operation of the bioreactor, continuing to optimize denitrification rates and eliminate discharge of toxic by-products (i.e. NO2 , NO, N2O or www.elsevier.nl/locate/aqua-online * Corresponding author. Tel.: +1-409-7722133; fax: +1-409-7726993. E-mail address: pglee@utmb.edu (P.G. Lee) 0144-8609/00/$ see front matter © 2000 Elsevier Science B.V. All rights reserved. PII: S0144 -8609 (00 )00046 -7 38 P.G. Lee et al. / Aquacultural Engineering 23 (2000) 37–59 H2S). The fuzzy logic rule base was composed of \40 fuzzy rules; it took into account the slow response time of the system. The fuzzy logic-based expert system maintained nitrate-nitrogen concentration B5 ppm while avoiding any increase in NO2 or H2S concentrations. © 2000 Elsevier Science B.V. All rights reserved.
Efficacy of photographic educational materials for carbohydrate counting training of adolescents with diabetes mellitus.

BACKGROUND
Carbohydrate counting (CHC) is ack - nowledged by the American Diabetes Association (ADA) as an important tool.


OBJECTIVE
To assess the efficacy of photographic educational materials to train adolescents with DM to perform CHC.


SUBJECTS AND METHODS
76 adolescents were randomly divided into two groups of CHC orientation: by means of photographic materials (Photo) or by a list of foods (List). One month afterwards, the participants were contacted via telephone to answer questions on CHC to reinforce the training (Quiz). Two days after taking the quiz, required the participants to visit an experimental kitchen to observe food portions in natura and to respond to a questionnaire on the weights in grams or carbohydrate equivalents of these portions. Statistical significance was established at p < 0.05.


RESULTS
54 adolescents completed the study (79.7% female), with 51.8% allocated to the Photo group and 48.1% to the List group. The mean age was 13.8 ± 2.0 years old, and the mean body mass index (BMI) was 21.0 ± 3.2 kg/m2. The participants had average of 7.9 ± 1.5 years of schooling, while their parents had 8.0 ± 3.8 years. The knowledge of CHC was similar in both groups before the intervention. After the intervention, the Photo group achieved a significantly higher hit difference on the CHC assessment test than the List group (Photo: 2.5 vs List: 1.0; p = 0.03).


CONCLUSIONS
The photographic educational material was more effective in helping adolescents with DM understand and learn to perform carbohydrate counting.
What happens when patients require intensification from basal insulin? A retrospective audit of clinical practice for the treatment of type 2 diabetes from four Australian centres.

AIMS
Little is known about clinical practices beyond the initiation of basal insulin in patients with type 2 diabetes mellitus (T2DM) in Australia. To determine the proportion of patients who progressed from basal insulin to each of three possible therapy groups: Group 1 addition of rapid-acting insulin, Group 2 switch to pre-mixed insulin, Group 3 addition of another therapy (incretin, glitazone, sulphonylurea, metformin, acarbose).


METHODS
Retrospective audit across four Australian hospital clinics. Patients had a diagnosis of T2DM, basal insulin had been initiated and a subsequent treatment intensification/change had occurred during the analysis period (September 2007-March 2012).


RESULTS
Patients were classified into one of three intensification groups for analysis: Group 1, 56.1% (111/198); Group 2, 22.7% (45/198) and Group 3, 21.2% (42/198). Prior to basal insulin initiation, mean T2DM duration was 11 years. Between starting basal insulin and treatment intensification, 42/183 (22.9%) patients achieved the HbA1c target of <7.0% (53 mmol/mol). Initiation of basal insulin provided temporary improvement in glycaemic control followed by subsequent deterioration. With further treatment intensification, only 40/180 (22.2%) patients achieved the HbA1c target of <7.0% (53 mmol/mol). Patients in the insulin groups gained weight (Group 1, rapid acting insulin, 1.9 ± 7.4 kg; Group 2, premixed insulin 2.3 ± 4.8 kg); those in Group 3 lost weight (-0.9 ± 13.54 kg). Hypoglycaemic episodes were uncommon irrespective of group.


CONCLUSIONS
There is continued need for improved patient management; individualised strategies should focus on when to initiate insulin, how to adjust and optimise doses over time and, when required, the introduction of intensification regimens.
A model of non-elemental olfactory learning in Drosophila

The pathways for olfactory learning in the fruitfly Drosophila have been extensively investigated, with mounting evidence that that the mushroom body is the site of the olfactory associative memory trace (Heisenberg, Nature 4:266–275, 2003; Gerber et al., Curr Opin Neurobiol 14:737–744, 2004). Heisenberg’s description of the mushroom body as an associative learning device is a testable hypothesis that relates the mushroom body’s function to its neural structure and input and output pathways. Here, we formalise a relatively complete computational model of the network interactions in the neural circuitry of the insect antennal lobe and mushroom body, to investigate their role in olfactory learning, and specifically, how this might support learning of complex (non-elemental; Giurfa, Curr Opin Neuroethol 13:726–735, 2003) discriminations involving compound stimuli. We find that the circuit is able to learn all tested non-elemental paradigms. This does not crucially depend on the number of Kenyon cells but rather on the connection strength of projection neurons to Kenyon cells, such that the Kenyon cells require a certain number of coincident inputs to fire. As a consequence, the encoding in the mushroom body resembles a unique cue or configural representation of compound stimuli (Pearce, Psychol Rev 101:587–607, 1994). Learning of some conditions, particularly negative patterning, is strongly affected by the assumption of normalisation effects occurring at the level of the antennal lobe. Surprisingly, the learning capacity of this circuit, which is a simplification of the actual circuitry in the fly, seems to be greater than the capacity expressed by the fly in shock-odour association experiments (Young et al. 2010).
MOF thin films: existing and future applications.

The applications and potentials of thin film coatings of metal-organic frameworks (MOFs) supported on various substrates are discussed in this critical review. Because the demand for fabricating such porous coatings is rather obvious, in the past years several synthesis schemes have been developed for the preparation of thin porous MOF films. Interestingly, although this is an emerging field seeing a rapid development a number of different applications on MOF films were either already demonstrated or have been proposed. This review focuses on the fabrication of continuous, thin porous films, either supported on solid substrates or as free-standing membranes. The availability of such two-dimensional types of porous coatings opened the door for a number of new perspectives for functionalizing surfaces. Also for the porous materials themselves, the availability of a solid support to which the MOF-films are rigidly (in a mechanical sense) anchored provides access to applications not available for the typical MOF powders with particle sizes of a few μm. We will also address some of the potential and applications of thin films in different fields like luminescence, QCM-based sensors, optoelectronics, gas separation and catalysis. A separate chapter has been devoted to the delamination of MOF thin films and discusses the potential to use them as free-standing membranes or as nano-containers. The review also demonstrates the possibility of using MOF thin films as model systems for detailed studies on MOF-related phenomena, e.g. adsorption and diffusion of small molecules into MOFs as well as the formation mechanism of MOFs (101 references).
Transfer Learning for Melanoma Detection: Participation in ISIC 2017 Skin Lesion Classification Challenge

This manuscript describes our participation in the International Skin Imaging Collaboration’s 2017 Skin Lesion Analysis Towards Melanoma Detection competition. We participated in Part 3: Lesion Classification. The two stated goals of this binary image classification challenge were to distinguish between (a) melanoma and (b) nevus and seborrheic keratosis, followed by distinguishing between (a) seborrheic keratosis and (b) nevus and melanoma. We chose a deep neural network approach with a transfer learning strategy, using a pre-trained Inception V3 network as both a feature extractor to provide input for a multi-layer perceptron as well as fine-tuning an augmented Inception network. This approach yielded validation set AUC’s of 0.84 on the second task and 0.76 on the first task, for an average AUC of 0.80. We joined the competition unfortunately late, and we look forward to improving on these results. Keywords—transfer learning; melanoma; seborrheic keratosis; nevus;
A framework for ensuring network security

The current focus of network security is concerned with securing individual components as well as preventing unauthorized access to network services. While these are necessary concerns, they do not represent a complete view of network security. In this paper, we present the Lucent Network Security Framework, which provides a comprehensive, top-down, end-to-end perspective on network security. We show how this framework can be applied to network elements, services, and applications including detecting, correcting, and preventing security vulnerabilities. In addition, we demonstrate how the Network Security Framework can be applied to all types of networks and across all layers of the protocol stack. This framework has been submitted to several government and standards bodies (e.g., ITU-T and ISO), and it has been very well received. Service provider networks developed with attention to the Lucent Network Security Framework will have a comprehensive security architecture enabling new value-added revenue-generating security services such as security service-level agreements (SLAs).
The role of team climate in the management of emotional labour: implications for nurse retention.

AIMS
This article examines the relationships among emotional labour, team climate, burnout, perceived quality of care and turnover intention among nurses in Australia, with the aim of addressing nurse retention and burnout.


BACKGROUND
Emotional labour refers to the regulation of emotion during interpersonal transactions. It may involve faking unfelt emotions, hiding genuine emotions and deep acting whereby the individuals attempt to influence their inner feelings to induce the appropriate outward countenance. Currently, there is a dearth of literature that investigates the link between emotional labour and perceived quality of care and ultimately turnover intention. The contribution of team climate in the relationship between emotional labour and burnout is still uncertain.


DESIGN
A cross-sectional quantitative study conducted with self-completed questionnaires.


METHODS
The study was conducted in 2011 with 201 registered nurses. Validated measures were used to measure the aforementioned constructs. Confirmatory factor analyses were used to examine the factor structure of the measured variables and hypotheses were tested using structural equation modelling.


RESULTS
The final model demonstrates that faking has a significant negative influence on perceived quality of care. Hiding predicts burnout, leading to an increase in turnover intention. Team climate moderates the relationship between hiding and burnout, which may subsequently influence turnover intention.


CONCLUSION
The establishment of a strong team climate may help nurses to manage the emotional demands of their role, promote their well-being and retention.
The Effects of a Gentle Yoga Program on Sleep, Mood, and Blood Pressure in Older Women with Restless Legs Syndrome (RLS): A Preliminary Randomized Controlled Trial

Objective. To examine the effects of yoga versus an educational film program on sleep, mood, perceived stress, and sympathetic activation in older women with RLS. Methods. Participants were drawn from a larger trial regarding the effects of yoga on cardiovascular disease risk profiles in overweight, sedentary postmenopausal women. Seventy-five women were randomized to receive either an 8-week yoga (n = 38) or educational film (n = 37) program. All 75 participants completed an RLS screening questionnaire. The 20 women who met all four diagnostic criteria for RLS (n = 10 yoga, 10 film group) comprised the population for this nested study. Main outcomes assessed pre- and post-treatment included: sleep (Pittsburgh Sleep Quality Index), stress (Perceived Stress Scale), mood (Profile of Mood States, State-Trait Anxiety Inventory), blood pressure, and heart rate. Results. The yoga group demonstrated significantly greater improvements than controls in multiple domains of sleep quality and mood, and significantly greater reductions in insomnia prevalence, anxiety, perceived stress, and blood pressure (all P's≤0.05). Adjusted intergroup effect sizes for psychosocial variables were large, ranging from 1.9 for state anxiety to 2.6 for sleep quality. Conclusions. These preliminary findings suggest yoga may offer an effective intervention for improving sleep, mood, perceived stress, and blood pressure in older women with RLS.
Application of automated video analysis for behavioural studies: concept and experience

Lund University, Sweden, is developing a video analysis system for making long-term behavioural studies, primarily in complex urban environments. Road users are detected using the KLT (Kanade-LucasTomasi) interest point tracker. Trajectories are estimated using foreground –background segmentation, whereas speed is estimated using the shape analysis of interest points. The extracted trajectories are further used for behavioural analysis. The authors present the experience from an ongoing study in Stockholm city, where the task was to find out if allowing two-way bicycle traffic on one-way streets had negative effects on safety. The video analysis system was applied to detect biking in the ‘wrong’ direction and analyse traffic conflicts between cyclists and other road users. The manual observations done in parallel allowed validating the accuracy of system performance.