LLukas22/scidocs huggingface dataset:
Relative stability of conventional and locked plating fixation in a model of the osteoporotic femoral diaphysis.

BACKGROUND
This study investigated the stiffness and strength of bridge plating with uni-cortical and bi-cortical locking plate constructs relative to a conventional, non-locked construct in the osteoporotic femoral diaphysis.


METHODS
Four bridge plating configurations were applied to a validated model of the osteoporotic femoral diaphysis. A non-locked conventional configuration served as baseline. Locked configurations included bi-cortical locked plating, uni-cortical locked plating and mix-mode locked plating, which combined uni and bi-cortical locking screws. For all configurations, an 11-hole plate was applied with 4.5-mm screws placed in the 1st, 3rd, and 5th plate hole. Five specimens of each configuration were dynamically loaded until failure in torsion, axial compression, and bending to determine construct stiffness, strength and failure modes.


FINDINGS
In torsion and bending, locked plating constructs provided a significantly lower stiffness and strength than the conventional construct. The uni-cortical locked construct was 69% weaker (P<0.001) in torsion than the conventional construct, but its torsional strength improved 73% (P<0.001) by adding one bi-cortical locked screw. In axial compression, construct stiffness varied by less than 10% between the four groups. However, the bi-cortical and mixed-mode locked constructs provided a significant increase in strength of 12% (P=0.001) and 11% (P=0.002), respectively, compared to the conventional construct.


INTERPRETATIONS
Locked plating in the osteoporotic diaphysis can improve fixation strength under axial loading, but may reduce fixation strength in bending and torsion compared to conventional plating. Adding one bi-cortical locked screw to an otherwise uni-cortical construct is recommended to improve torsional strength.
Economic order quantity models for ameliorating/deteriorating items under inflation and time discounting

The items that incur a gradual loss in quality or quantity over time while in inventory are usually called deteriorating items. In reality, there are some items whose value or utility or quantity increase with time and those items can be termed as ameliorating items. In this paper, an effort has been made to incorporate these two opposite physical characteristics of stored items into inventory model. We develop models for ameliorating/deteriorating items with timevarying demand pattern over a finite planning horizon, taking into account the effects of inflation and time value of money. Optimal solutions of the proposed models are derived and the effects of amelioration/deterioration on the inventory replenishment policies are studied with the help of numerical examples. 2003 Elsevier B.V. All rights reserved.
Particle effects on friction and wear of aluminium matrix composites

Particle effects on friction and wear of 6061 aluminium (6061 AI) reinforced with silicon carbide (SIC) and alumina (AI203) particles were investigated by means of Vickers microhardness measurements and scratch tests. Unreinforced 6061 AI matrix alloy was also studied for comparison. To explore the effect of heat treatment, materials subjected to three different heat treatment conditions, i.e. under-aged, over-aged and T6, were used. Multiplescratch tests using a diamond and a steel indenter were also carried out to simulate real abrasive wear processes. Vickers microhardness measurements indicated that T6 heattreated composites had the highest hardness. Single-scratch tests showed that the variation of friction coefficient was similar to that of Vickers hardness and the peak-aged composites exhibited the best wear resistance. The wear rate of fine particle-reinforced composites was mainly affected by hardness. However, thewear rate of large particle-reinforced composites was influenced by both the hardness and fracture of the particles.
Self-Talk and Sports Performance: A Meta-Analysis.

Based on the premise that what people think influences their actions, self-talk strategies have been developed to direct and facilitate human performance. In this article, we present a meta-analytic review of the effects of self-talk interventions on task performance in sport and possible factors that may moderate the effectiveness of self-talk. A total of 32 studies yielding 62 effect sizes were included in the final meta-analytic pool. The analysis revealed a positive moderate effect size (ES = .48). The moderator analyses showed that self-talk interventions were more effective for tasks involving relatively fine, compared with relatively gross, motor demands, and for novel, compared with well-learned, tasks. Instructional self-talk was more effective for fine tasks than was motivational self-talk; moreover, instructional self-talk was more effective for fine tasks rather than gross tasks. Finally, interventions including self-talk training were more effective than those not including self-talk training. The results of this study establish the effectiveness of self-talk in sport, encourage the use of self-talk as a strategy to facilitate learning and enhance performance, and provide new research directions.
3D representation of the Mandelbrot set

A new 3D representation of the Mandelbrot set is presented. Although the method employing the Douady Hubbard's potential function has been useful for the 3D representation of the Mandelbrot set, in our new method 3D pictures are generated by setting height components normal to the plane of the original Mandelbrot set. The pictures obtained look like natural landscapes with cliffs.
Prevalence and prognostic significance of hyponatraemia in outpatients with chronic heart failure.

AIM
Hyponatraemia has been reported to be a potent predictor of poor outcome in patients hospitalized for heart failure (HF). The aim of the study was to determine the prevalence and prognostic significance of hyponatraemia in a large cohort of HF outpatients followed in clinics participating in the Danish Heart Failure Clinics Network.


METHODS AND RESULTS
The study population consisted of consecutive patients referred for HF management in 18 Danish heart failure clinics. Overall, 2863 patients (83%) had a normal plasma sodium (p-sodium) level and 602 patients (17%) had hyponatraemia with a p-sodium level <136 mmol/L. Outcome data were obtained from a validated, national registry. Patients were elderly with a mean age of 68 years. The mean P-[Na+] was 139.6 ± 2.4 mmol/L among patients with normonatraemia and 132.4 ± 3.2 mmol/L among patients with hyponatraemia. In multivariate Cox Proportional Hazard Models adjusted for confounders (age, gender, hospitalization within the last 90 days, loop diuretics, creatinine level, systolic blood pressure, New York Heart Association class III-IV, left ventricular ejection fraction <0.46, ischaemic heart disease and diabetes) hyponatraemic patients had increased risk of hospitalization or death [hazard ratio (HR) 1.2 (95% confidence interval (CI) 1.0-1.4, P = 0.011)]. Hyponatraemia was also an independent predictor of all-cause mortality [HR 1.5 (95% CI 1.2-1.9, P< 0.001)]. There was no interaction between hyponatraemia and the covariables on outcome in the multivariable models.


CONCLUSION
The presence of hyponatraemia in outpatients with HF is associated with increased risk of hospitalization or death.
Trends in survival for patients with metastatic soft-tissue sarcoma.

BACKGROUND
The objective of this study was to determine whether the overall survival of patients with metastatic soft tissue sarcoma (STS) has improved over the last 20 years.


METHODS
In total, 1024 patients who had synchronous metastatic (SM) STS or metachronous metastatic (MM) STS diagnosed between 1987 and 2006 were included prospectively in the French Sarcoma Group database after central histologic review. Four periods of diagnosis of metastatic disease were defined: P1, from 1987 to 1991 (n = 208); P2, from 1992 to 1996 (n = 287); P3, from 1997 to 2001 (n = 285); and P4, from 2002 to 2006 (n = 244). Patient characteristics were analyzed as prognostic factors by using a Cox model.


RESULTS
The proportion of patients with SM, the interval between diagnosis and MM, and the clinical characteristics of the patients were similar across the 4 periods. Although there was no significant difference in the median overall survival (OS) from P1 through P2 (P1, 12.3 months; 95% confidence interval [CI], 9.9-14.7 months; P2, 11.4 months; 95% CI, 9-13.9 months), significant improvements were observed in the later periods (P3, 15 months; 95% CI, 11.8-18.2 months; P4, 18 months; 95% CI, 15.3-20.7 months; P = .029; log-rank test). The 2-year OS rate also increased throughout the study period from 28.1% during P1 to 38.7% during P4. On multivariate analysis, period of diagnosis, age, histologic subtype, time to metastatic recurrence, French Federation of Cancer Centers Sarcoma Group grade, and the number of metastatic sites were independent prognostic factors for OS.


CONCLUSIONS
The current analysis revealed that the median OS of patients with metastatic STS had improved by 50% during the last 20 years. These data should be considered in the interpretation of results from ongoing and future STS trials.
Bone Fracture Detection Algorithms Based on Image Processing-A Survey

Fracture in bone occurs when an external force exercised upon the bone is more than what the bone can tolerate or bear. As, its consequence structure and muscular power of the bone is disturbed and bone becomes frail, which causes tormenting pain on the bone and ends up in the loss of functioning of bone. Accurate bone structure and fracture detection is achieved using various algorithms which removes noise, enhances image details and highlights the fracture region. Automatic detection of fractures from x-ray images is considered as an important process in medical image analysis by both orthopaedic and radiologic aspect. Manual examination of x-rays has multitude drawbacks. The process is time consuming and subjective. In this paper we discuss several digital image processing techniques applied in fracture detection of bone. This led us to study techniques that have been applied to images obtained from different modalities like x-ray, CT, MRI and ultrasound. Keywords— Fracture detection, Medical Imaging, Morphology, Tibia, X-ray image
The effect of organizational support on ERP implementation

Purpose – The purpose of this paper is to propose a model to examine the impact of organizational support on behavioral intention (BI) regarding enterprise resource planning (ERP) implementation based on the technology acceptance model (TAM). Design/methodology/approach – A research model is proposed which describes the effects of organizational support, both formal and informal, on factors of TAM. A survey questionnaire is developed to test the proposed model. A total of 700 of questionnaires are distributed to users in small and medium enterprises that have implemented ERP systems in Korea and 209 responses are used for analyses. Structural equation modeling is employed to test the research hypotheses. Findings – The results indicate that the organizational support is an important factor for perceived usefulness (PU) and perceived ease of use (PEOU). PU and PEOU seem to lead to a higher level of interest in the ERP system and BI to use the system. The most notable finding of our study is that organizational support is positively associated with factors of TAM. Research limitations/implications – The survey data used in this paper are collected from smalland medium-sized companies in South Korea. Thus, the respondents in these firms might have been trained at different levels or on different modules of ERP, which would yield diversity in subject experience with different ERP systems. Originality/value – To improve the efficiency and effectiveness of ERP implementation in a real world environment, organizations need to better understand user satisfaction. The TAM model provides a theoretical construct to explain how user satisfaction is affected.
Selection and validation of quality indicators for the Shorter Stays in Emergency Departments National Research Project.

OBJECTIVE
Despite the spread of time targets for ED lengths of stay around the world, there have been few studies exploring the effects of such policies on quality of ED care. The Shorter Stays in Emergency Departments (SSED) National Research Project seeks to address this. The purpose of this paper was to describe how the indicators for the SSED study in New Zealand were selected and validated.


METHODS
A literature review was used to identify potential indicators. A reference group of 25 key stakeholders from across the health system was convened, with the aims of validating the suggested indicators and to ensure that other candidate indicators were not overlooked. A thematic analysis using a general inductive approach was used to analyse focus group discussions.


RESULTS
The major themes were communication, access, timeliness, appropriateness and satisfaction. The 12 indicators selected after literature review were confirmed and two further indicators added after the thematic analysis. The indicators are: hospital and ED length of stay; re-presentation within 48 h; mortality; times to reperfusion, antibiotics, asthma treatment, analgesia, CT for head injury and to theatre (appendicitis and fractured neck of femur); triage time compliance; proportion who left without being seen; quality of discharge information; and ED overcrowding/access block.


CONCLUSION
Through literature review and consultation with stakeholders, an evidence-based and clinically relevant set of indicators was compiled with which to measure the effect of the SSED target. This indicator set is consistent with recent international recommendations for measuring quality of care in EDs.
Eligibility for magnetic resonance imaging screening in the United Kingdom: effect of strict selection criteria and anonymous DNA testing on breast cancer incidence in the MARIBS Study.

INTRODUCTION
A UK multicenter study compared the performance of contrast enhanced-magnetic resonance imaging with X-Ray Mammography in women at high-risk of breast cancer commencing in 1997. Selection criteria were used to identify women with at least 0.9% annual risk of breast cancer.


METHODS
Women at high breast cancer risk, with a strong family history and/or high probability of a BRCA1/BRCA2/TP53 mutation, were recruited from 22 centers. Those not known as gene carriers were asked to give a blood sample, which was tested anonymously for mutations. Women ages 35 to 49 years were offered annual screening for 2 to 7 years. Study eligibility at entry was assessed retrospectively by detailed examination of pedigrees and overall eligibility accounting for computer risk assessment and mutation results.


RESULTS
Seventy-eight of 837 (9%) women entered for screening were ineligible using the strict entry criteria. Thirty-nine cancers were detected in 1,869 women-years in study (incidence 21 per 1,000). Including 3,561 further years follow-up, 28 more breast cancers were identified (12 of 1,000). Incidence rates for 759 eligible women were 22 of 1,000 in study and 13 of 1,000 in total follow-up, compared with 9 of 1,000 and 4 of 1,000, respectively, in 78 ineligible women. Breast cancer rates were higher for BRCA2 than BRCA1 after testing anonymized samples in this selected population at 65 of 1,000 in study and 36 of 1,000 in total follow-up for BRCA2 compared with 44 of 1,000 and 27 of 1,000 for BRCA1.


CONCLUSIONS
Strict enforcement of study criteria would have minimally improved the power of the study, whereas testing for BRCA1/2 in advance would have substantially increased the detection rates.
Prevalence and comorbidity of allergic diseases in preschool children

PURPOSE
Allergic disease and its comorbidities significantly influence the quality of life. Although the comorbidities of allergic diseases are well described in adult populations, little is known about them in preschool children. In the present study, we aimed to assess the prevalence and comorbidity of allergic diseases in Korean preschool children.


METHODS
We conducted a cross-sectional study comprising 615 Korean children (age, 3 to 6 years). Symptoms of allergic diseases were assessed using the Korean version of the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire that was modified for preschool children. Comorbidities of allergic diseases were assessed by 'In the last 12 months, has your child had symptoms?'.


RESULTS
The prevalence of symptoms of asthma, allergic rhinitis, and atopic dermatitis as recorded using the ISAAC questionnaire, within the last 12 months was 13.8%, 40.7%, and 20.8%, respectively. The symptom rates of allergic conjunctivitis, food allergy, and drug allergy were 14.8%, 10.4%, and 0.8%, respectively. The prevalence of allergic rhinitis in children with asthma was 64.3% and that of asthma in children with allergic rhinitis was 21.6%. The prevalence of rhinitis in children with conjunctivitis was 64.8% and that of conjunctivitis in children with rhinitis was 23.6%.


CONCLUSION
The prevalence of current rhinitis in our preschool children is shown to be higher than that previously reported. Allergic conjunctivitis is closely associated with asthma and allergic rhinitis. However, further studies are warranted to determine the prevalence and effects of these comorbidities on health outcomes in preschool children.
Enabling Work: Occupational Therapy Interventions for Persons with Occupational Injuries and Diseases: A Scoping Review

Purpose This review aims to map the scope of published research on occupational therapy (OT) interventions and pertinent work and work-related outcomes for persons with occupational injuries and diseases. Methods The scoping review adapted Arksey and O’Malley’s framework. Six electronic databases were searched. Ancestral search was also done on five systematic reviews. The search was conducted from September 2015 to October 2015. Interventions and outcomes were coded using the International Classification of Functioning, Disability and Health Core Set for Vocational Rehabilitation to plot trends. Results Forty-six articles were included in the review. The top five intervention approaches included: acquiring skills (12.27%), health services, systems, and policies (10.43%), products and technology for employment (9.20%), handling stress and other psychological demands (7.98%), and apprenticeship (6.74%). The top five outcomes targeted included: remunerative employment (15.71%); sensation of pain (10.99%); emotional functions (5.76%); handling stress and other psychological demands (5.76%); economic self-sufficiency (4.71%); muscle endurance functions (4.71%); exercise tolerance functions (4.71%); undertaking multiple tasks (4.19%); acquiring, keeping, and terminating a job (4.19%); and looking after one’s health (4.19%). Conclusion The trend in interventions show the use of activities and environment facilitators which are attuned to the conceptual nature of OT. Furthermore, the trend in outcomes show that there is substantial evidence that supports the use of OT to target work. This review may provide a platform for collaboration with other professionals and also help identify research directions to strengthen the evidence base for OT in work-related practice.
Proteinuria patterns and their association with subsequent end-stage renal disease in IgA nephropathy.

BACKGROUND
Proteinuria (UP) >1.0 g/24 h at diagnosis is a well-known indicator of progressive renal disease in patients with IgA nephropathy (IgAN). To determine if persistent UP is a more sensitive marker for later progression of IgAN, the hypothesis was tested that the prior level and trend (slope) in UP for 1 year was better at predicting later end-stage renal disease (ESRD) (dialysis or transplant) than a current 24-h UP, serum creatinine (SC), SC slope, hypertension, or total glomerular histopathological score on index renal biopsy in an observational study of 154 high-risk patients enrolled in two clinical trials (IgAN 1, IgAN 2).


METHODS
Measurements of 24-h UP and SC were made at time 0, 6 weeks, 6 months and 1 year in all patients, who were then followed for an additional 5.76 years and 1.63 years in the two studies, respectively. The Cox proportional hazards model was used to identify predictors of ESRD following the 1-year visit.


RESULTS
Adjusting only for randomized treatment, nearly all UP variables (number of high readings, 1-year level, slopes), SC at 1 year, and SC trends (slopes) over the prior year were significantly associated with subsequent ESRD (all P values <0.05) in both studies. However, among the UP variables, the 1-year readings had the strongest association with ESRD in IgAN 1 (hazard ratio (HR), 95% CI, for a 1g increase: 1.5, 1.2,1.9), and the second strongest association (similar to UP trends) in IgAN 2 (1.4, 1.2,1.6). Males had lower rates of ESRD in both studies (IgAN 1 HR: 0.5, 0.2,1.2, P=0.11; IgAN 2 HR: 0.2, 0.1,0.6, P=0.002). In the multivariate analyses that examined all clinical and histological variables, 1-year levels of 24-h UP and SC, and female gender were independently associated with subsequent ESRD.


CONCLUSION
In a high-risk patient with IgAN, the current 24-h UP and SC measurements are as good predictors of subsequent ESRD as UP and SC trends and levels over the prior year. Additionally, it appears that females have poorer outcomes than males.