LLukas22/scidocs huggingface dataset:
Polymer-Free Biolimus A9-Coated Stents in the Treatment of De Novo Coronary Lesions: 4- and 12-Month Angiographic Follow-Up and Final 5-Year Clinical Outcomes of the Prospective, Multicenter BioFreedom FIM Clinical Trial.

OBJECTIVES
The purpose of this study was to evaluate the efficacy and long-term outcomes of a novel polymer/carrier-free drug-coated stent (DCS) in patients with de novo coronary lesions.


BACKGROUND
The BioFreedom (BFD) DCS incorporates a low-profile, stainless-steel platform, with a surface that has been modified to create a selectively microstructured abluminal surface that allows adhesion and further release of Biolimus A9 (Biosensors Europe SA, Morges, Switzerland).


METHODS
A total of 182 patients (183 lesions) were randomized into a 1:1:1 ratio for treatment with BFD "standard dose" (BFD) or BFD "low dose" (BFD-LD) versus first-generation paclitaxel-eluting stents (PES) at 4 sites in Germany.


RESULTS
Baseline and procedural characteristics were well matched. At 4-month angiographic follow-up (Cohort 1, n = 75), in-stent late lumen loss (LLL) was significantly lower with BFD and BFD-LD versus PES (0.08 and 0.12 mm vs. 0.37 mm, respectively; p < 0.0001 for BFD vs. PES, and p = 0.002 for BFD-LD vs. PES). At 12 months (Cohort 2, n = 107), in-stent LLL (primary endpoint) was 0.17 mm in BFD versus 0.35 mm in PES (p = 0.001 for noninferiority; p = 0.11 for superiority); however, the BFD-LD (0.22 mm) did not reach noninferiority (p = 0.21). At 5 years (175 of 182), there were no significant differences in major adverse cardiac events (23.8%, 26.4%, and 20.3%) and clinically indicated target lesion revascularization (10.8%, 13.4%, and 10.2%) for BFD, BFD-LD, and PES, respectively; also, there was no definite/probable stent thrombosis reported.


CONCLUSIONS
The BFD, but not the BFD-LD, demonstrated noninferiority versus PES in terms of in-stent LLL, a surrogate of neointimal hyperplasia, at 12-month follow-up. At 5 years, clinical event rates were similar, without occurrence of stent thrombosis in all groups. (BioFreedom FIM Clinical Trial; NCT01172119).
Executive control and decision-making in the prefrontal cortex

action sets thus comprise multiple stimulusaction and (stimulus)-action-outcome associations, which are learned and continuously adjusted online for maximizing rewards. Computational modeling suggest that stimulus-action and (stimulus)-action-outcome associations are learned and adjusted through reinforcement and statistical learning respectively [33 ,34], while abstract action sets emerge through probabilistic clustering processes [29]. Collectively, these flexible representations invoked together for driving action selection while the same external situation perpetuates, constitute a consistent behavioral strategy also referred to as a task set (Figure 1). Task sets and adaptive behavior Task sets are critical executive units for efficient adaptive behavior in everyday environments featuring external situations that often change and may reoccur periodically Current Opinion in Behavioral Sciences 2015, 1:101–106 102 Cognitive neuroscience
Recent advances in image reconstruction, coil sensitivity calibration, and coil array design for SMASH and generalized parallel MRI

Parallel magnetic resonance imaging (MRI) techniques use spatial information from arrays of radiofrequency (RF) detector coils to accelerate imaging. A number of parallel MRI techniques have been described in recent years, and numerous clinical applications are currently being explored. The advent of practical parallel imaging presents various challenges for image reconstruction and RF system design. Recent advances in tailored SiMultaneous Acquisition of Spatial Harmonics (SMASH) image reconstructions are summarized. These advances enable robust SMASH imaging in arbitrary image planes with a wide range of coil array geometries. A generalized formalism is described which may be used to understand the relations between SMASH and SENSE, to derive typical implementations of each as special cases, and to form hybrid techniques combining some of the advantages of both. Accurate knowledge of coil sensitivities is crucial for parallel MRI, and errors in calibration represent one of the most common and the most pernicious sources of error in parallel image reconstructions. As one example, motion of the patient and or the coil array between the sensitivity reference scan and the accelerated acquisition can lead to calibration errors and reconstruction artifacts. Self-calibrating parallel MRI approaches that address this problem by eliminating the need for external sensitivity references are reviewed. The ultimate achievable signal-to-noise ratio (SNR) for parallel MRI studies is closely tied to the geometry and sensitivity patterns of the coil arrays used for spatial encoding. Several parallel imaging array designs that depart from the traditional model of overlapped adjacent loop elements are described.
The "delay effect" of donning a gown during cardiopulmonary resuscitation in a simulation model.

OBJECTIVE
We sought to determine whether the use of currently issued gowns delays initiation of chest compressions and ventilations during cardiopulmonary resuscitation and whether simple gown modifications can reduce this delay.


METHODS
Firefighter defibrillation instructors were allocated into pairs and videotaped while performing standardized cardiac arrest scenarios. Three scenarios were compared: "no gown," "standard gown" and "modified gown." Key time intervals were extracted from videotaped data.


RESULTS
Ninety-five scenarios were analyzed. Mean time interval to chest compression was 39 seconds (95% confidence interval [CI] 34-43) for "no gown" scenarios, 71 seconds (95% CI 66-77) for "standard gown" scenarios and 59 seconds (95% CI 54-63) for "modified gown" scenarios (p < 0.001). Time to first ventilation was 146 seconds (95% CI 134-158), 238 seconds (95% CI 224-253) and 210 seconds (95% CI 198-223) in the 3 groups, respectively (p < 0.001). Post hoc testing showed that the time differences between all groups were statistically significant.


CONCLUSION
Standard gowns protect front-line care providers but cause significant delays to chest compressions and ventilations, potentially increasing patient morbidity and mortality. Minor gown modifications, including pre-tied neck straps and longer waist ties that tie in front, allow for easier use and shorter delays to time-critical interventions. Future research is required to reduce care delays while maintaining adequate protection of emergency medical service providers from infectious disease.
Investigating the Experiences of Childhood Cancer Patients and Parents Participating in Optional Nontherapeutic Clinical Research Studies in the UK

BACKGROUND
While the majority of childhood cancer clinical trials are treatment related, additional optional research investigations may be carried out that do not directly impact on treatment. It is essential that these studies are conducted ethically and that the experiences of families participating in these studies are as positive as possible.


METHODS
A questionnaire study was carried out to investigate the key factors that influence why families choose to participate in optional nontherapeutic research studies, the level of understanding of the trials involved, and the experiences of participation.


RESULTS
A total of 100 participants from six UK centers were studied; 77 parents, 10 patients >16 years, and 13 patients aged 8-15 years. Ninety-seven percent of parents and 90% of patients felt that information provided prior to study consent was of the right length, with 52% of parents and 65% of patients fully understanding the information provided. Seventy-four percent of parents participated in research studies in order to "do something important", while 74% of patients participated "to help medical staff". Encouragingly, <5% of participants felt that their clinical care would be negatively affected if they did not participate. Positive aspects of participation included a perception of increased attention from medical staff. Negative aspects included spending longer periods in hospital and the requirement for additional blood samples. Ninety-six percent of parents and 87% of patients would participate in future studies.


CONCLUSIONS
The study provides an insight into the views of childhood cancer patients and their parents participating in nontherapeutic clinical research studies. Overwhelmingly, the findings suggest that participation is seen as a positive experience.
Empowering individuals with do-it-yourself assistive technology

Assistive Technologies empower individuals to accomplish tasks they might not be able to do otherwise. Unfortunately, a large percentage of Assistive Technology devices that are purchased (35% or more) end up unused or abandoned [7,10], leaving many people with Assistive Technology that is inappropriate for their needs. Low acceptance rates of Assistive Technology occur for many reasons, but common factors include 1) lack of considering user opinion in selection, 2) ease in obtaining devices, 3) poor device performance, and 4) changes in user needs and priorities [7]. We are working to help more people gain access to the Assistive Technology they need by empowering non-engineers to "Do-It-Yourself" (DIY) and create, modify, or build. This paper illustrates that it is possible to custom-build Assistive Technology, and argues why empowering users to make their own Assistive Technology can improve the adoption process (and subsequently adoption rates). We discuss DIY experiences and impressions from individuals who have either built Assistive Technology before, or rely on it. We found that increased control over design elements, passion, and cost motivated individuals to make their own Assistive Technology instead of buying it. We discuss how a new generation of rapid prototyping tools and online communities can empower more individuals. We synthesize our findings into design recommendations to help promote future DIY-AT success.
Trust Me: Social Games are Better than Social Icebreakers at Building Trust

Interpersonal trust is one of the key components of efficient teamwork. Research suggests two main approaches for trust formation: personal information exchange (e.g., social icebreakers), and creating a context of risk and interdependence (e.g., trust falls). However, because these strategies are difficult to implement in an online setting, trust is more difficult to achieve and preserve in distributed teams. In this paper, we argue that games are an optimal environment for trust formation because they can simulate both risk and interdependence. Results of our online experiment show that a social game can be more effective than a social task at fostering interpersonal trust. Furthermore, trust formation through the game is reliable, but trust depends on several contingencies in the social task. Our work suggests that gameplay interactions do not merely promote impoverished versions of the rich ties formed through conversation; but rather engender genuine social bonds. \
A single neurotoxic dose of MDMA decreases BDNF expression in the frontoparietal cortex but not in the hippocampus

Background The popular recreational abuse drug 3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy') produces acute and long-lasting deficits in several markers of the serotonergic (5-HT) system. BDNF (brain derived neurotrophic factor) is a prominent trophic factor of serotonergic fibers. The aim of this study was to characterize the damage of serotonergic fibers in the frontoparietal cortex and hippocampus in parallel with the expression of BDNF.
A Case of Unerupted Lower Primary Second Molar Associated with Compound Odontoma

Odontoma is the most common type of benign odontogenic tumor, and often causes disturbances in the eruption of its associated tooth. Odontomas usually occur in the permanent dentition, and rarely occur solely in the primary dentition. This case report documents a six-year-old-child with a compound odontoma located in the mandible, which caused the impaction of the primary second molar.
Ontology-Based Nutrient Solution Control System for Hydroponics

This paper presents the Ontology-based Nutrient Solution Control System for Hydroponics with Protégé. We consider variables of electrical conductivity (EC), Potential of Hydrogen ion (pH), intensity of solution, species of plants and the relation of the device in the system for supporting to make the suitable decisions with the control system of hydroponic nutrient solution.
The development of a scale to measure the experience of spiritual connection and the correlation between this experience and values

Previous research shows religiosity (across several religions) is associated with conservative values (tradition, conformity and security) from the Schwartz value scale and not with spiritually oriented, self-transcendent values. The relationship between religiosity and spirituality is controversial. We developed a 48-item scale, the Spiritual Connection Questionnaire (SCQ)-48, to measure experience and beliefs of spiritual connection, an aspect of spirituality that is consistent with religious and non-religious or New Age interpretations of spirituality. We selected 14 items (SCQ-14) that best predicted health and then tested the correlation between the SCQ-14 and the SVS in a student and an older population in the UK. In both populations the SCQ-14 was negatively associated with values at the self-enhancing value pole (power, security and hedonism) and in the older population was positively associated with a value at the self-transcendent value pole (universalism, but not benevolence). Religiosity has been shown to be associated with values that enhance societal identification and hence inter-group differentiation and conflict. By contrast, we found that the experience of spiritual connection is associated with values that reduce inter-group differentiation. Despite these differences, we found that self-reported religiosity enhances spiritual experience. Copyright © 2008 John Wiley and Sons, Ltd.
Super Resolution Image Generation Using Wavelet Domain Interpolation With Edge Extraction via a Sparse Representation

This letter addresses the problem of generating a super-resolution (SR) image from a single low-resolution (LR) input image in the wavelet domain. To achieve a sharper image, an intermediate stage for estimating the high-frequency (HF) subbands has been proposed. This stage includes an edge preservation procedure and mutual interpolation between the input LR image and the HF subband images, as performed via the discrete wavelet transform (DWT). Sparse mixing weights are calculated over blocks of coefficients in an image, which provides a sparse signal representation in the LR image. All of the subband images are used to generate the new high-resolution image using the inverse DWT. Experimental results indicated that the proposed approach outperforms existing methods in terms of objective criteria and subjective perception improving the image resolution.
Effect of mesh type, surgeon and selected patients’ characteristics on the treatment of inguinal hernia with the Lichtenstein technique. Randomized trial

INTRODUCTION
Though not entirely free of complications, the Lichtenstein technique is still considered the "gold standard" for inguinal hernia repair due to the low recurrence rate.


AIM
In our study we determined the effect of mesh type, surgeon and selected patients' characteristics on treatment results. The latter were determined by the frequency of early complications, recovery time and return to normal activities, chronic pain and hernia recurrence.


MATERIAL AND METHODS
Tension-free hernia repair with the Lichtenstein technique was performed in 149 male patients aged 20-89 years randomized to two trial groups. One group comprised 76 patients with heavyweight non-absorbable polypropylene mesh (HW group) and the other included 73 patients with lightweight partially absorbable mesh (LW group). The control schedule follow-up took place on the 7(th) day as well as in the 3(rd) and 6(th) month after the operation. Statistical analysis was performed with multi-factor regression models.


RESULTS
In the LW group patients returned to normal activity faster (p = 0.031), experienced less intensive chronic pain (p = 0.01) and expressed higher treatment satisfaction (p = 0.024) than the patients from the HW group. The type of mesh had an insignificant influence on the risk of early complications and hernia recurrence. Statistically significant differences were observed however with regard to surgeon, type and hernia duration, patient's general condition and body mass.


CONCLUSIONS
Both types of mesh are equally effective for prevention of hernia recurrence. Lightweight partially absorbable meshes are more beneficial to patients than the heavyweight non-absorbable type. The surgeon and patients' characteristics have a significant impact on the treatment outcome.
GetReal in network meta-analysis: a review of the methodology.

Pairwise meta-analysis is an established statistical tool for synthesizing evidence from multiple trials, but it is informative only about the relative efficacy of two specific interventions. The usefulness of pairwise meta-analysis is thus limited in real-life medical practice, where many competing interventions may be available for a certain condition and studies informing some of the pairwise comparisons may be lacking. This commonly encountered scenario has led to the development of network meta-analysis (NMA). In the last decade, several applications, methodological developments, and empirical studies in NMA have been published, and the area is thriving as its relevance to public health is increasingly recognized. This article presents a review of the relevant literature on NMA methodology aiming to pinpoint the developments that have appeared in the field. Copyright © 2016 John Wiley & Sons, Ltd.
This ought to be good: brain activity accompanying positive and negative expectations and outcomes.

The current study employed a modified gambling task, in which probabilistic cues were provided to elicit positive or negative expectations. Event-related potentials (ERPs) to "final outcome" and "probabilistic cues" were analyzed. Difference waves between the negative condition and the corresponding positive condition were examined. The results confirm that feedback related negativity (FRN) amplitude is modulated by the interaction of outcome valence and expectancy by showing larger FRN difference waves for unexpected than expected outcomes. More interestingly, the difference wave between ERPs elicited by positive and negative expectations showed a negative deflection, with a frontal midline source density around 280 ms after onset of the predictive cue. Negative expectations were associated with larger FRN amplitudes than positive expectations. This suggests that FRN is elicited by probabilistic cues to pending outcomes.
When grandiosity and vulnerability collide: Implicit and explicit self-esteem in patients with narcissistic personality disorder.

BACKGROUND AND OBJECTIVES
Narcissistic personality disorder (NPD) is characterized by reports of grandiosity including exaggerated illusions of superiority and entitlement (DSM-IV-TR, APA, 2000). Based on clinical theories (e.g., Kernberg, 1975), many researchers argue that high explicit self-esteem in narcissists masks underlying implicit vulnerability (low implicit self-esteem). Conversely, based on social learning theories (i.e., Millon, 1981), people with NPD are characterized by implicit grandiosity (high implicit self-esteem). We test these competing hypotheses in patients diagnosed with NPD.


METHODS
The present study examined implicit self-esteem (using an Implicit Association Test) and explicit self-esteem (using a self-report questionnaire) in patients with NPD in comparison to non-clinical and clinical, non-NPD (Borderline Personality Disorder, BPD) control groups.


RESULTS
Patients with NPD scored lower on explicit self-esteem than non-clinical controls. In comparison to patients with BPD, NPD patients scored higher on explicit and implicit self-esteem. Moreover, within the group of NPD patients, damaged self-esteem (i.e., low explicit, high implicit) was associated with higher narcissistic psychopathology.


LIMITATIONS
In both clinical groups we included participants seeking psychiatric treatment, which might influence explicit self-esteem. Longitudinal studies are needed to further assess self-esteem stability in NPD patients in comparison to the control groups.


CONCLUSIONS
Our findings are indicative of vulnerable facets in patients with NPD (i.e., low explicit self-esteem). Furthermore, damaged self-esteem is connected to specific psychopathology within the NPD group. Implications for research on NPD are discussed.
Health care informatics

The health care industry is currently experiencing a fundamental change. Health care organizations are reorganizing their processes to reduce costs, be more competitive, and provide better and more personalized customer care. This new business strategy requires health care organizations to implement new technologies, such as Internet applications, enterprise systems, and mobile technologies in order to achieve their desired business changes. This article offers a conceptual model for implementing new information systems, integrating internal data, and linking suppliers and patients.
Differences in Heart Rate Variability Associated with Long-Term Exposure to NO2

BACKGROUND
Heart rate variability (HRV), a measure of cardiac autonomic tone, has been associated with cardiovascular morbidity and mortality. Short-term studies have shown that subjects exposed to higher traffic-associated air pollutant levels have lower HRV.


OBJECTIVE
Our objective was to investigate the effect of long-term exposure to nitrogen dioxide on HRV in the Swiss cohort Study on Air Pollution and Lung Diseases in Adults (SAPALDIA).


METHODS
We recorded 24-hr electrocardiograms in randomly selected SAPALDIA participants >or= 50 years of age. Other examinations included an interview investigating health status and measurements of blood pressure, body height, and weight. Annual exposure to NO2 at the address of residence was predicted by hybrid models (i.e., a combination of dispersion predictions, land-use, and meteorologic parameters). We estimated the association between NO2 and HRV in multivariable linear regression models. Complete data for analyses were available for 1,408 subjects.


RESULTS
For women, but not for men, each 10-microg/m3 increment in 1-year averaged NO2 level was associated with a decrement of 3% (95% CI, -4 to -1) for the standard deviation of all normal-to-normal RR intervals (SDNN), -6% (95% CI, -11 to -1) for nighttime low frequency (LF), and -5% (95% CI, -9 to 0) for nighttime LF/high-frequency (HF) ratio. We saw no significant effect for 24-hr total power (TP), HF, LF, or LF/HF or for nighttime SDNN, TP, or HF. In subjects with self-reported cardiovascular problems, SDNN decreased by 4% (95% CI, -8 to -1) per 10-microg/m3 increase in NO2.


CONCLUSIONS
There is some evidence that long-term exposure to NO2 is associated with cardiac autonomic dysfunction in elderly women and in subjects with cardiovascular disease.