LLukas22/scidocs huggingface dataset:
Bone regeneration using a hollow hydroxyapatite space-maintaining device for maxillary sinus floor augmentation--a clinical pilot study.

BACKGROUND
The mere lifting of the maxillary sinus membrane by implants protruding into the sinus cavity allows the establishment of a void space for blood clot and new bone formation.


PURPOSE
To evaluate bone formation by using a spherical, hollow, and perforated hydroxyapatite space-maintaining device (HSMD) in a two-stage sinus lift procedure where residual alveolar bone height was ≤2 mm.


MATERIAL AND METHODS
Spherical, hollow, and perforated HSMDs with a diameter of 12 mm were manufactured for this pilot study. Three patients with a residual bone height of 1-2 mm, as verified clinically and radiographically, and in need of a sinus augmentation procedure prior to implant installation were selected for the study. The HSMD and bone formation was evaluated by cone beam computerized tomography (CBCT) 6 months after augmentation procedure. Implants were installed 6 to 9 months after augmentation. The implant sites were prepared by a trephine drill to obtain a specimen of HSMD and bone for histological evaluation. After implant installation, the condition of the sinus membrane adjacent to the HSMD was evaluated endoscopically. After an additional 8 weeks, fixed partial prostheses were fabricated.


RESULTS
Bone formation verified by CBCT was found around and inside the device in all three patients after 6 months. Despite the fact that residual bone before augmentation was ≤2 mm, 12-mm-long implants with diameter of 4.8 mm could be inserted with preservation of an intact and healthy sinus membrane verified endoscopically. Bone formation inside HSMDs was noted histologically in two out of three HSMDs. Implants were stable and without any marginal bone loss after 1 year of prosthetic loading.


CONCLUSION
A spherical, hollow, and perforated HSMD used in sinus lift procedures can produce a void space for blood clot and new bone formation and subsequent implant installation.
The Process of Probability Problem Solving: Use of External Visual Representations

We investigate the role of external inscriptions, particularly those of a spatial or visual nature, in the solution of probability word problems. We define a taxonomy of external visual representations used in probability problem solving that includes pictures, spatial reorganization of the given information, outcome listings, contingency tables, Venn diagrams, trees, and novel graphical representations. We also propose a process model for probability problem solving (PPS) and use it as a framework to better understand how and why external visual representations are used. In a study of 34 novice probability problem solvers, participants worked to solve six probability word problems covering six probability subtopics. Both written and verbal structured interview protocols were analyzed to investigate when and how external visual representations are spontaneously used by problem solvers. Analyses of the coded transcripts showed that participants’ probability problem-solving efforts move through the stages of PPS in a sequential but not always linear manner, sometimes exhibiting iterated attempts to represent the problem mathematically and to find a solution strategy. Results showed that use of specific external visual representations was associated with specific probability topics, and that certain choices of representation are associated with higher rates of solution success. These findings suggest that an external visual representation can facilitate probability problem solving, but only when an appropriate representation is chosen. Finally, we present evidence to show that external visual representations are usually created and first used during the stages of representing the problem mathematically and finding a solution strategy. However, pictures are often created during the initial stage of problem text understanding, and tables are sometimes created during computation of the solution.
Security lapses and the omission of information security measures: A threat control model and empirical test

Organizations and individuals are increasingly impacted by misuses of information that result from security lapses. Most of the cumulative research on information security has investigated the technical side of this critical issue, but securing organizational systems has its grounding in personal behavior. The fact remains that even with implementing mandatory controls, the application of computing defenses has not kept pace with abusers’ attempts to undermine them. Studies of information security contravention behaviors have focused on some aspects of security lapses and have provided some behavioral recommendations such as punishment of offenders or ethics training. While this research has provided some insight on information security contravention, they leave incomplete our understanding of the omission of information security measures among people who know how to protect their systems but fail to do so. Yet carelessness with information and failure to take available precautions contributes to significant civil losses and even to crimes. Explanatory theory to guide research that might help to answer important questions about how to treat this omission problem lacks empirical testing. This empirical study uses protection motivation theory to articulate and test a threat control model to validate assumptions and better understand the ‘‘knowing-doing” gap, so that more effective interventions can be developed. 2008 Elsevier Ltd. All rights reserved. d. All rights reserved. Workman), wbommer@csufresno.edu (W.H. Bommer), dstraub@gsu.edu 2800 M. Workman et al. / Computers in Human Behavior 24 (2008) 2799–2816
Robust adaptive control of robots with arbitrary transient performance and disturbance attenuation

We consider the tracking problem for robot manipulators with unknown and (possibly) time-varying parameters, which are subject to bounded disturbances. We provide a state feedback adaptive control algorithm which guarantees arbitrary transient performance as well as arbitrary disturbance attenuation. If the disturbances vanish and the parameters remain constant, the proposed controller achieves asymptotic tracking.
Ambiguity and ambiguity aversion

The phenomena of ambiguity and ambiguity aversion, introduced in Daniel Ellsberg’s seminal 1961 article, are ubiquitous in the real-world and violate both the key rationality axioms and classic models of choice under uncertainty. In particular, they violate the hypothesis that individuals’ uncertain beliefs can be represented by subjective probabilities (sometimes called personal probabilities or priors). This chapter begins with a review of early notions of subjective probability and Leonard Savage’s joint axiomatic formalization of expected utility and subjective probability. It goes on to describe Ellsberg’s classic urn paradoxes and the extensive experimental literature they have inspired. It continues with analytical descriptions of the numerous (primarily axiomatic) models of ambiguity aversion which have been developed by economic theorists, and concludes with a discussion of some current theoretical topics and newer examples of ambiguity aversion.
An Evaluation of the Effects of INSIGHTS on the Behavior of Inner City Primary School Children

A prevention trial was conducted to evaluate a temperament-based intervention (INSIGHTS into Children's Temperament) as compared to a Read Aloud attention control condition in reducing behavior problems among inner city children. The participants were 148 inner-city first and second grade children, their parents, and their 46 teachers who were from six schools in a Northeastern city. Parents were interviewed on the Parent Daily Report at baseline and every two weeks until the completion of the intervention phase to assess the extent of child problem behaviors in the home. The parents also were interviewed at baseline with the Disruptive Module of the Diagnostic Interview for Children and completed the Brief Symptom Index to assess parental depression. A repeated measures multivariate analysis of covariance with parental depression as a covariate was conducted to examine the children's behavior over the course of the intervention. In order to test the impact of INSIGHTS for the overall sample and to determine whether the intervention was differentially effective for children diagnosed with a disruptive disorder versus those who did not receive a diagnosis, two and three-way interactions were examined and found to be significant. The INSIGHTS intervention was more effective than Read Aloud in reducing children's problem behaviors at home across both the diagnosed and non-diagnosed groups, but demonstrated a significantly greater efficacy among children who were at diagnostic levels compared to those who were within normal levels. Editors' Strategic Implications: The authors describe the promising practice of instructing parents and teachers on how to adapt their behavior management strategies to fit each child's temperament. Replication with a longitudinal follow-up will be necessary to determine whether program effects persist.
Bi-objective Scheduling with cooperating Heuristics for Embedded Real-Time Systems

Received Jan 5, 2018 Revised Feb 14, 2018 Accepted Feb 28, 2018 This paper proposes Makespan and Reliability based approach, a static sheduling strategy for distributed real time embedded systems that aims to optimize the Makespan and the reliability of an application. This scheduling problem is NP-hard and we rely on a heuristic algorithm to obtain efficiently approximate solutions. Two contributions have to be outlined: First, a hierarchical cooperation between heuristics ensuring to treat alternatively the objectives and second, an Adapatation Module allowing to improve solution exploration by extending the search space. It results a set of compromising solutions offering the designer the possibility to make choices in line with his (her) needs. The method was tested and experimental results are provided.
SCADA Systems: Challenges for Forensic Investigators

When security incidents occur, several challenges exist for conducting an effective forensic investigation of SCADA systems, which run 24/7 to control and monitor industrial and infrastructure processes. The Web extra at http://youtu.be/L0EFnr-famg is an audio interview with Irfan Ahmed about SCADA (supervisory control and data acquisition) systems.
Increasing pressure on freshwater resources due to terrestrial feed ingredients for aquaculture production.

As aquaculture becomes more important for feeding the growing world population, so too do the required natural resources needed to produce aquaculture feed. While there is potential to replace fish meal and fish oil with terrestrial feed ingredients, it is important to understand both the positive and negative implications of such a development. The use of feed with a large proportion of terrestrial feed may reduce the pressure on fisheries to provide feed for fish, but at the same time it may significantly increase the pressure on freshwater resources, due to water consumption and pollution in crop production for aquafeed. Here the green, blue and gray water footprint of cultured fish and crustaceans related to the production of commercial feed for the year 2008 has been determined for the major farmed species, representing 88% of total fed production. The green, blue and gray production-weighted average feed water footprints of fish and crustaceans fed commercial aquafeed are estimated at 1629 m3/t, 179 m3/t and 166 m3/t, respectively. The estimated global total water footprint of commercial aquafeed was 31-35 km3 in 2008. The top five contributors to the total water footprint of commercial feed are Nile tilapia, Grass carp, Whiteleg shrimp, Common carp and Atlantic salmon, which together have a water footprint of 18.2 km3. An analysis of alternative diets revealed that the replacement of fish meal and fish oil with terrestrial feed ingredients may further increase pressure on freshwater resources. At the same time economic consumptive water productivity may be reduced, especially for carnivorous species. The results of the present study show that, for the aquaculture sector to grow sustainably, freshwater consumption and pollution due to aquafeed need to be taken into account.
Racial differences in the association of serum 25-hydroxyvitamin D concentration with coronary heart disease events.

IMPORTANCE
Low circulating concentrations of 25-hydroxyvitamin D (25[OH]D) have been consistently associated with an increased risk of coronary heart disease (CHD) in white populations. This association has not been rigorously evaluated in other races or ethnicities, in which the distributions of 25(OH)D concentration and possibly other aspects of 25(OH)D metabolism differ.


OBJECTIVE
To examine the association of serum 25(OH)D concentration with risk of CHD in a multiethnic population.


DESIGN, SETTING, AND PARTICIPANTS
We studied 6436 participants in the Multi-Ethnic Study of Atherosclerosis (MESA), recruited from July 2000 through September 2002, who were free of known cardiovascular disease at baseline. We measured baseline serum 25(OH)D concentrations using a mass spectrometry assay calibrated to established standards. We tested associations of 25(OH)D with adjudicated CHD events assessed through May 2012.


MAIN OUTCOME AND MEASURES
Primary outcome measure was time to first adjudicated CHD event, defined as myocardial infarction, angina, cardiac arrest, or CHD death.


RESULTS
During a median follow-up of 8.5 years, 361 participants had an incident CHD event (7.38 events per 1000 person-years). Associations of 25(OH)D with CHD differed by race/ethnicity (P for interaction < .05). After adjustment, lower 25(OH)D concentration was associated with a greater risk of incident CHD among participants who were white (n = 167 events; hazard ratio [HR], 1.26 [95% CI, 1.06-1.49] for each 10-ng/mL decrement in 25(OH)D) or Chinese (HR, 1.67 [95% CI, 1.07-2.61]; n = 27). In contrast, 25(OH)D was not associated with risk of CHD in participants who were black (HR, 0.93 [95% CI, 0.73-1.20]; n = 94) or Hispanic (HR, 1.01 [95% CI, 0.77-1.33]; n = 73).


CONCLUSIONS AND RELEVANCE
Lower serum 25(OH)D concentration was associated with an increased risk of incident CHD events among participants who were white or Chinese but not black or Hispanic. Results evaluating 25(OH)D in ethnically homogeneous populations may not be broadly generalizable to other racial or ethnic groups.
Dear Parents of College Freshmen

The transition to college is a dramatic change for most, and God is in all the details." Posting about sending a child off to college from In All Things an online hub committed to the claim that the life, death, and resurrection of Jesus Christ has implications for the entire world. http://inallthings.org/dear-parents-of-college-freshmen/
Dermoscopy of poikilodermatous mycosis fungoides (MF).

the First Clinical College, Nanjing University of Chinese edicine, and Department of Dermatology, Affiliated Hospital Nanjing University of Chinese Medicine. orted in part by the National Natural Science Foundation of hina (Grant No. 81173400). licts of interest: None declared. int requests: Cheng Tan, MD, Department of Dermatology, ffiliated Hospital of Nanjing University of Chinese Medicine, 155 Hanzhong Road, Nanjing, China 210029. E-mail: tancheng@ medmail.com.cn. J Am Acad Dermatol 2016;74:e45-7. 0190-9622/$36.00 a 2015 by the American Academy of Dermatology, Inc. http://dx.doi.org/10.1016/j.jaad.2015.10.031
Association between Polymorphisms in the Renin-Angiotensin-Aldosterone System Genes and Essential Hypertension in the Han Chinese Population

BACKGROUND
Renin-angiotensin-aldosterone system (RAAS) is the most important endocrine blood pressure control mechanism in our body, genes encoding components of this system have been strong candidates for the investigation of the genetic basis of hypertension. However, previous studies mainly focused on limited polymorphisms, thus we carried out a case-control study in the Han Chinese population to systemically investigate the association between polymorphisms in the RAAS genes and essential hypertension.


METHODS
905 essential hypertensive cases and 905 normotensive controls were recruited based on stringent inclusion and exclusion criteria. All 41 tagSNPs within RAAS genes were retrieved from HapMap, and the genotyping was performed using the GenomeLab SNPstream Genotyping System. Logistic regression analysis, Multifactor dimensionality reduction (MDR), stratified analysis and crossover analysis were used to identify and characterize interactions among the SNPs and the non-genetic factors.


RESULTS
Serum levels of total cholesterol (TC) and triglyceride (TG), and body mass index (BMI) were significantly higher in the hypertensive group than in the control group. Of 41 SNPs genotyped, rs3789678 and rs2493132 within AGT, rs4305 within ACE, rs275645 within AGTR1, rs3802230 and rs10086846 within CYP11B2 were shown to associate with hypertension. The MDR analysis demonstrated that the interaction between BMI and rs4305 increased the susceptibility to hypertension. Crossover analysis and stratified analysis further indicated that BMI has a major effect, and rs4305 has a minor effect.


CONCLUSION
These novel findings indicated that together with non-genetic factors, these genetic variants in the RAAS may play an important role in determining an individual's susceptibility to hypertension in the Han Chinese.
The CORE Service Improvement Programme for mental health crisis resolution teams: study protocol for a cluster-randomised controlled trial

BACKGROUND
As an alternative to hospital admission, crisis resolution teams (CRTs) provide intensive home treatment to people experiencing mental health crises. Trial evidence supports the effectiveness of the CRT model, but research suggests that the anticipated reductions in inpatient admissions and increased user satisfaction with acute care have been less than hoped for following the scaling up of CRTs nationally in England, as mandated by the National Health Service (NHS) Plan in 2000. The organisation and service delivery of the CRTs vary substantially. This may reflect the lack of a fully specified CRT model and the resources to enhance team model fidelity and to improve service quality. We will evaluate the impact of a CRT service improvement programme over a 1-year period on the service users' experiences of care, service use, staff well-being, and team model fidelity.


METHODS/DESIGN
Twenty-five CRTs from eight NHS Trusts across England will be recruited to this cluster-randomised trial: 15 CRTs will be randomised to receive the service improvement programme over a 1-year period, and ten CRTs will not receive the programme. Data will be collected from 15 service users and all clinical staff from each participating CRT at baseline and at the end of the intervention. Service use data will be collected from the services' electronic records systems for two 6-month periods: the period preceding and the period during months 7-12 of the intervention. The study's primary outcome is service user satisfaction with CRT care, measured using a client satisfaction questionnaire. Secondary outcomes include the following: perceived continuity of care, hospital admission rates and bed use, rates of readmission to acute care following CRT support, staff morale, job satisfaction, and general health. The adherence of the services to a model of best practice will be assessed at baseline and follow-up. Outcomes will be compared between the intervention and control teams, adjusting for baseline differences and participant characteristics using linear random effects modelling. Qualitative investigations with participating CRT managers and staff and programme facilitators will explore the experiences of the service improvement programme.


DISCUSSION
Our trial will show whether a theoretically underpinned and clearly defined package of resources are effective in supporting service improvement and improving outcomes for mental health crisis resolution teams.


TRIAL REGISTRATION
Current Controlled Trials ISRCTN47185233.
Prospects for a Zika Virus Vaccine.

A recent unprecedented outbreak of Zika virus (ZIKV) in the Americas has been associated with microcephaly and other congenital malformations in infants as well as Guillain-Barre syndrome in adults. The development of a safe and effective ZIKV vaccine is therefore an urgent global health priority. Promising data from preclinical vaccine studies in mice and monkeys suggest that an effective vaccine will likely be possible, but important scientific challenges remain. Here we review the current state of ZIKV vaccine development. We discuss different vaccination strategies and we highlight challenges facing clinical evaluation of ZIKV vaccine candidates.
Impact of hierarchical modular structure on ranking of individual nodes in directed networks

Many systems, ranging from biological and engineering systems to social systems, can be modeled as directed networks, with links representing directed interaction between two nodes. To assess the importance of a node in a directed network, various centrality measures based on different criteria have been proposed. However, calculating the centrality of a node is often difficult because of the overwhelming size of the network or because the information held about the network is incomplete. Thus, developing an approximation method for estimating centrality measures is needed. In this study, we focus on modular networks; many real-world networks are composed of modules, where connection is dense within a module and sparse across different modules. We show that ranking-type centrality measures, including the PageRank, can be efficiently estimated once the modular structure of a network is extracted. We develop an analytical method to evaluate the centrality of nodes by combining the local property (i.e. indegree and outdegree of nodes) and the global property (i.e. centrality of modules). The proposed method is corroborated by real data. Our results provide a linkage between the ranking-type centrality values of modules and those of individual nodes. They also reveal the hierarchical structure of 5 Author to whom any correspondence should be addressed. New Journal of Physics 11 (2009) 113002 1367-2630/09/113002+21$30.00 © IOP Publishing Ltd and Deutsche Physikalische Gesellschaft
Cultivating the sense of belonging and motivating user participation in virtual communities: A social capital perspective

Virtual communities (VCs) are attracting more attention as they provide a platform for people to share experiences and knowledge, which may further impact their purchase decisions. From a social capital perspective, this study investigated factors that cultivate a VC member’s sense of belonging and their effects on facilitating his participation in the VC in terms of the intentions to get and share experiences