LLukas22/scidocs huggingface dataset:
Counterfactual domain adversarial training of neural networks

A number of domain adaptation techniques have been developed in classical supervised machine learning to solve the problem of learning under domain shift. Unfortunately, almost no attempt has been made to exploit their potential use for causal inference. In this paper, we present a conceptual framework which leverages on one of these successes by adopting Domain Adversarial of Neural Network (DANN) [1] and make it work within the context of causal inference. More specifically, we attempt to modify an existing counterfactual prediction framework based on domain adaptation (DA) [2] with a deep neural network and discrepancy distance measure to enable us instead to perform causal inference in an adversarial way. We achieved this by jointly minimizing the risk in the feature reconstruction and the counterfactual prediction while maximizing the error in discriminating between the distribution of subjects that received intervention and those that received no intervention. This way, a domain invariant yet discriminative model that will generalize well on the counterfactual target distribution is produced.
Specializations of the human upper respiratory and upper digestive systems as seen through comparative and developmental anatomy

The human upper respiratory, or aerodigestive, tract serves as the crossroads of our breathing, swallowing and vocalizing pathways. Accordingly, developmental or evolutionary change in any of these functions will, of necessity, affect the others. Our studies have shown that the position in the neck of the mammalian larynx is a major factor in determining function in this region. Most mammals, such as our closest relatives the nonhuman primates, exhibit a larynx positioned high in the neck. This permits an intranarial larynx to be present and creates largely separate respiratory and digestive routes. While infant humans retain this basic mammalian pattern, developmental descent of the larynx considerably alters this configuration. Adult humans have, accordingly, lost separation of the respiratory and digestive routes, but have gained an increased supralaryngeal region of the pharynx which allows for the production of the varied sounds of human speech. How this region has changed during human evolution has been difficult to assess due to the absence of preserved soft-tissue structures. Our studies have shown that the relationship between basicranial shape and laryngeal position in living mammals can be a valuable guide to reconstruct the region in ancestral humans. Based on these findings we have examined the basicrania of fossil ancestors—from over two million years ago to near recent times—and have reconstructed the position of the larynx and pharyngeal region in these early forms. This has allowed us insight into how our ancestors may have breathed and swallowed, and when the anatomy necessary for human speech evolved.
High-Step-Up and High-Efficiency Fuel-Cell Power-Generation System With Active-Clamp Flyback–Forward Converter

A high-efficiency fuel-cell power-generation system with an active-clamp flyback-forward converter is presented in this paper to boost a 12-V dc voltage into a 220-V 50-Hz ac voltage. The proposed system includes a high-efficiency high-step-up interleaved soft-switching flyback-forward converter and a full-bridge inverter. The front-end active-clamp flyback-forward converter has the advantages of zero-voltage-switching performance for all the primary switches, reverse-recovery-problem alleviation for the secondary output diodes, large voltage-conversion ratio, and small input-current ripple. Furthermore, there are two coupled inductors in the proposed converter. Each coupled inductor can work in the flyback mode when the corresponding main switch is in the turn-on state and in the forward mode when it is in the turnoff state, which takes full use of the magnetic core and improves the power density. In addition, the full-bridge inverter with an LC low-pass filter is adopted to provide low-total-harmonic-distortion ac voltage to the load. Therefore, high-efficiency and high-power-density conversion can be achieved in a wide input-voltage range by employing the proposed system. Finally, a 500-W prototype and another 1-kW converter are implemented and tested to verify the effectiveness of the proposed system.
Analysis and design of broadside-coupled striplines-fed bow-tie antennas

The design of a bow-tie antenna fed by broadside-coupled striplines (BCS) for the 2.4-GHz ISM band is described in this letter. The two fins of the bow tie are, respectively, on the two sides of the substrate. The feeding balanced lines adopted are the BCS. A quarterwave transformer is used to transform the microtrip line input to the BCS feed. Analysis method based on the mixed-potential integral equation method is used to characterize the input characteristics of the bow-tie antenna. Obtained numerical results are in good agreement with experimental data. Through experiments with bow-tie antennas of various extended angles, the bow-tie antenna with a 90 extended angle exhibits the widest bandwidth in the desired frequency band, which has a bandwidth of 19% for VSWR < 1.5 : 1.
Probability estimation for an automotive Pre-Crash application with short filter settling times

In this paper, the merits of incorporating covariance propagation into a real-time Pre-Crash application are investigated. The suggested Pre-Crash algorithm activates restraint systems, such as a reversible seat belt tightening system, before an unavoidable accident happens. Sensor fusion of two short-range and one long-range radar with a target-based fusion is used to realize this vehicle safety application. A powerful, yet applicable method for using not only state but also covariance information for triggering actuators is proposed. A comprehensive parameter study on simulated as well as on real data shows statistically significant improvements in detection rate. Further, the importance of covariance errors in terms of accuracy for Pre-Crash applications is demonstrated. Even with few detection cycles and short filter settling times, a good compromise between detection rate and false alarms can be deduced.
Effects of Pilates, McKenzie and Heckscher training on disease activity, spinal motility and pulmonary function in patients with ankylosing spondylitis: a randomized controlled trial

The optimal management of ankylosis spondylitis (AS) involves a combination of nonpharmacologic and pharmacologic treatment aiming to maximize health-related quality of life. The primary objective of our study was to demonstrate the benefits of an original multimodal exercise program combining Pilates, McKenzie and Heckscher techniques on pulmonary function in patients with AS, while secondary objectives were to demonstrate the benefits of the same program on function and disease activity. This is a randomized controlled study on ninety-six consecutive patients with AS (axial disease subset), assigned on a 1:1 rationale into two groups based on their participation in the Pilates, McKenzie and Heckscher (group I) or in the classical kinetic program (group II). The exercise program consisted of 50-min sessions performed 3 times weekly for 48 weeks. Standard assessments were done at week 0 and 48 and included pain, modified Schober test (mST) and finger–floor distance (FFD), chest expansion (CE) and vital capacity (VC), as well as disease activity Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), functional Bath Ankylosing Spondylitis Functional Index (BASFI) and metrology index Bath Ankylosing Spondylitis Metrology Index (BASMI). Groups were comparable at baseline; we demonstrated significant improvement between baseline and after 48 weeks of regular kinetic training for all AS-related parameters in both groups. However, significant improvement was found in pain, lumbar spine motility (mST, FFD), BASFI, BASDAI and BASMI in AS performing the specific multimodal exercise program at the end of study (p = 0.001). Although there were significant improvements in CE in both groups as compared to baseline (group I, p = 0.001; group II, p = 0.002), this parameter increased significantly only in group I (p = 0.001). VC measurements were not significantly changed at the end of the study (group I, p = 0.127; group II, p = 0.997), but we found significant differences within groups (p = 0.011). A multimodal training combining Pilates, McKenzie and Heckscher exercises performed regularly should be included in the routine management of patients with AS for better control of function, disease activity and pulmonary function.
REFRAMING SUPPLY CHAIN MANAGEMENT : A SERVICE-DOMINANT

Shifting the dominant thinking of supply chain management toward the concepts of service, value cocreation, value propositions, operant resources, networks, service ecosystems and learning opens up many research opportunities and strategies for improved organizational performance. The emerging thought world of service-dominant logic is presented as a means to reframe supply chain scholarship and practice for increased relevance and impact.
Simulating wireless and mobile networks in OMNeT++ the MiXiM vision

Wireless communication has attracted considerable interest in the research community, and many wireless networks are evaluated using discrete event simulators like OMNeT++. Although OMNeT++ provides a powerful and clear simulation framework, it lacks of direct support and a concise modeling chain for wireless communication. Both is provided by MiXiM. MiXiM joins and extends several existing simulation frameworks developed for wireless and mobile simulations in OMNeT++. It provides detailed models of the wireless channel (fading, etc.), wireless connectivity, mobility models, models for obstacles and many communication protocols especially at the Medium Access Control (MAC) level. Further, it provides a user-friendly graphical representation of wireless and mobile networks in OMNeT++, supporting debugging and defining even complex wireless scenarios. Though still in development, MiXiM already is a powerful tool for performance analysis of wireless networks. Its extensive functionality and clear concept may motivate researches to contribute to this open-source project [4].
Pharmaceutical care program for patients with uncontrolled hypertension. Report of a double-blind clinical trial with ambulatory blood pressure monitoring.

BACKGROUND
Pharmaceutical care programs may be an option to improve blood pressure (BP) control in patients with uncontrolled hypertension. The aim of this study was to evaluate the efficacy of pharmaceutical care programs in treating patients with resistant hypertension.


METHODS
In a double-blind randomized clinical trial, 71 patients with uncontrolled BP were enrolled in a pharmaceutical care program or in a control group and underwent a series of cognitive tests. The primary outcome was change in ambulatory BP (ABP) between the baseline evaluation and the final visit 6 months later. The secondary outcomes were the frequency of drug-related problems and adherence as determined by plasma levels of hydrochlorothiazide.


RESULTS
The delta-values between the intervention and control groups for ABP in the different daily periods, with the corresponding 95% confidence limits, adjusted for age and baseline BP were: 3 (-1 to 5), 2 (-2 to 4), and 5 (-1 to 6) mm Hg for 24 h, daily and nightly systolic BP, respectively. The corresponding values for diastolic BP were 1 (-1 to 3), 0 (-2 to 2), and 3 (-1 to 4) mm Hg, respectively. Hydrochlorothiazide was detected in the plasma in 21 of 27 patients in the intervention group that attended to all appointments and 24 of 30 patients in the control group (P = .904).


CONCLUSIONS
The pharmaceutical care program tested in this trial was feasible and showed a trend for better BP control in patients with uncontrolled hypertension.
International variation in lung cancer mortality rates and trends among women.

BACKGROUND
There is no recent comprehensive global analysis of lung cancer mortality in women. We describe contemporary mortality rates and trends among women globally.


METHODS
We used the World Health Organization's Cancer Mortality Database covering 65 populations on six continents to calculate age-standardized (1960 Segi world standard) lung cancer death rates during 2006 to 2010 and annual percent change in rates for available years from 1985 to 2011 and for the most recent five data years by population and age group (30-49 and 50-74 years).


RESULTS
Lung cancer mortality rates (per 100,000) among young women (30-49 years) during 2006 to 2010 ranged from 0.7 in Costa Rica to 14.8 in Hungary. Rates among young women were stable or declining in 47 of 52 populations examined. Rates among women 50 to 74 years ranged from 8.8 in Georgia and Egypt to 120.0 in Scotland. In both age groups, rates were highest in parts of Europe (Scotland, Hungary, Denmark) and North America and lowest in Africa, Asia, and Latin America. Rates in older women were increasing for more than half (36/64) of populations examined, including most countries in Southern, Eastern, and Western Europe and South America.


CONCLUSIONS
Although widespread reductions in lung cancer in young women provide evidence of tobacco control success, rates continue to increase among older women in many countries.


IMPACT
More concentrated efforts to initiate or expand tobacco control programs in these countries globally will be required to attenuate the future lung cancer burden. Cancer Epidemiol Biomarkers Prev; 23(6); 1025-36. ©2014 AACR.
Alemtuzumab versus interferon beta 1a as first-line treatment for patients with relapsing-remitting multiple sclerosis: a randomised controlled phase 3 trial

BACKGROUND
The anti-CD52 monoclonal antibody alemtuzumab reduced disease activity in a phase 2 trial of previously untreated patients with relapsing-remitting multiple sclerosis. We aimed to assess efficacy and safety of first-line alemtuzumab compared with interferon beta 1a in a phase 3 trial.


METHODS
In our 2 year, rater-masked, randomised controlled phase 3 trial, we enrolled adults aged 18-50 years with previously untreated relapsing-remitting multiple sclerosis. Eligible participants were randomly allocated in a 2:1 ratio by an interactive voice response system, stratified by site, to receive intravenous alemtuzumab 12 mg per day or subcutaneous interferon beta 1a 44 μg. Interferon beta 1a was given three-times per week and alemtuzumab was given once per day for 5 days at baseline and once per day for 3 days at 12 months. Coprimary endpoints were relapse rate and time to 6 month sustained accumulation of disability in all patients who received at least one dose of study drug. This study is registered with ClinicalTrials.gov, number NCT00530348.


FINDINGS
187 (96%) of 195 patients randomly allocated interferon beta 1a and 376 (97%) of 386 patients randomly allocated alemtuzumab were included in the primary analyses. 75 (40%) patients in the interferon beta 1a group relapsed (122 events) compared with 82 (22%) patients in the alemtuzumab group (119 events; rate ratio 0·45 [95% CI 0·32-0·63]; p<0.0001), corresponding to a 54·9% improvement with alemtuzumab. Based on Kaplan-Meier estimates, 59% of patients in the interferon beta 1a group were relapse-free at 2 years compared with 78% of patients in the alemtuzumab group (p<0·0001). 20 (11%) of patients in the interferon beta 1a group had sustained accumulation of disability compared with 30 (8%) in the alemtuzumab group (hazard ratio 0·70 [95% CI 0·40-1·23]; p=0·22). 338 (90%) of patients in the alemtuzumab group had infusion-associated reactions; 12 (3%) of which were regarded as serious. Infections, predominantly of mild or moderate severity, occurred in 253 (67%) patients treated with alemtuzumab versus 85 (45%) patients treated with interferon beta 1a. 62 (16%) patients treated with alemtuzumab had herpes infections (predominantly cutaneous) compared with three (2%) patients treated with interferon beta 1a. By 24 months, 68 (18%) patients in the alemtuzumab group had thyroid-associated adverse events compared with 12 (6%) in the interferon beta 1a group, and three (1%) had immune thrombocytopenia compared with none in the interferon beta 1a group. Two patients in the alemtuzumab group developed thyroid papillary carcinoma.


INTERPRETATION
Alemtuzumab's consistent safety profile and benefit in terms of reductions of relapse support its use for patients with previously untreated relapsing-remitting multiple sclerosis; however, benefit in terms of disability endpoints noted in previous trials was not observed here.


FUNDING
Genzyme (Sanofi) and Bayer Schering Pharma.
Tirofiban and sirolimus-eluting stent vs abciximab and bare-metal stent for acute myocardial infarction: a randomized trial.

CONTEXT
Bare-metal stenting with abciximab pretreatment is currently considered a reasonable reperfusion strategy for acute ST-segment elevation myocardial infarction (STEMI). Sirolimus-eluting stents significantly reduce the need for target-vessel revascularization (TVR) vs bare-metal stents but substantially increase procedural costs. At current European list prices, the use of tirofiban instead of abciximab would absorb the difference in cost between stenting with sirolimus-eluting vs bare-metal stents.


OBJECTIVE
To evaluate the clinical and angiographic impact of single high-dose bolus tirofiban plus sirolimus-eluting stenting vs abciximab plus bare-metal stenting in patients with STEMI.


DESIGN, SETTING, AND PATIENTS
Prospective, single-blind, randomized controlled study (Single High Dose Bolus Tirofiban and Sirolimus Eluting Stent vs Abciximab and Bare Metal Stent in Myocardial Infarction [STRATEGY]) of 175 patients (median age, 63 [interquartile range, 55-72] years) presenting to a single referral center in Italy with STEMI or presumed new left bundle-branch block and randomized between March 6, 2003, and April 23, 2004.


INTERVENTION
Single high-dose bolus tirofiban regimen plus sirolimus-eluting stenting (n = 87) vs standard-dose abciximab plus bare-metal stenting (n = 88).


MAIN OUTCOME MEASURES
The primary end point was a composite of death, nonfatal myocardial infarction, stroke, or binary restenosis at 8 months. Secondary outcomes included freedom, at day 30 and month 8, from major cardiac or cerebrovascular adverse events (composite of death, reinfarction, stroke, and repeat TVR).


RESULTS
Cumulatively, 14 of 74 patients (19%; 95% confidence interval [CI], 10%-28%) in the tirofiban plus sirolimus-eluting stent group and 37 of 74 patients (50%; 95% CI, 44%-56%) in the abciximab plus bare-metal stent group reached the primary end point (hazard ratio, 0.33; 95% CI, 0.18-0.60; P<.001 [P<.001 by Fischer exact test]). The cumulative incidence of death, reinfarction, stroke, or TVR was significantly lower in the tirofiban plus sirolimus-eluting stent group (18%) vs the abciximab plus bare-metal stent group (32%) (hazard ratio, 0.53; 95% CI, 0.28-0.92; P = .04), predominantly reflecting a reduction in the need for TVR. Binary restenosis was present in 6 of 67 (9%; 95% CI, 2%-16%) and 24 of 66 (36%; 95% CI, 26%-46%) patients in the tirofiban plus sirolimus-eluting stent and abciximab plus bare-metal stent groups, respectively (P = .002).


CONCLUSION
Tirofiban-supported sirolimus-eluting stenting of infarcted arteries holds promise for improving outcomes while limiting health care expenditure in patients with myocardial infarction undergoing primary intervention.
Enhanced Data Security in Cloud Computing with Third Party Auditor

Cloud computing is environment which enables convenient, efficient, on-demand network access to a shared pool of configurable computing resources (e.g., networks, servers, storage, applications, and services) that can be rapidly provisioned and released with minimal management effort or service provider interaction. Cloud is kind of centralized database where many organizations/clients store their data, retrieve data and possibly modify data. Cloud is a model where user is provided services by CSP(Cloud Service Provider) on pay per use base. Means here Client has to pay for what he is using or being served. Data stored and retrieved in such a way may not be fully trustworthy so here concept of TPA(Third Party Auditor) is used. TPA makes task of client easy by verifying integrity of data stored on behalf of client. In cloud, there is support for data dynamics means clients can insert, delete or can update data so there should be security mechanism which ensure integrity for the same. Here TPA can not only see the data but he can access data or can modify also so there should be some security mechanism against this. Keywords— Third Party Auditor, Software as a Service, Cloud Service Provider
Effects on Spatial Presence, Transportation, Flow, and Enjoyment

Dubbing and subtitling are the two most common methods of translating television broadcasts or movies. Both dubbing and subtitling may present specific advantages and disadvantages. In this study, the effects of these two methods on presence, transportation, flow, and enjoyment were investigated in an experimental approach. Participants (N = 154) watched a 30-min segment of a movie. Between-subject factors were translation method (dubbing without subtitles, dubbing with subtitles in a foreign language, and original language with subtitles) and genre (drama, comedy, and thriller). Findings indicate that subtitles in a foreign language decrease feelings of spatial presence, transportation, and flow. However, the difference between dubbing and subtitling failed to reach significance. No effect of translation method on enjoyment was found. The pattern of results is equal for all genres. Further analyses showed spatial presence, transportation, and flow to be related. In addition, transportation is more strongly related to enjoyment than flow and spatial presence.
Implantation of AMS 700 LGX penile prosthesis preserves penile length without the need for penile lengthening procedures

Implantation of an inflatable penile prosthesis (IPP) is a well-established definitive solution for erectile dysfunction when conservative treatments fail. Penile implants may shorten the penis. The AMS 700 LGX IPP is in common use but reports on its mechanical reliability, medium-term postsurgical patient satisfaction, and mean penile length preservation are lacking. We investigate the mean penile length, mechanical reliability, and patient satisfaction at 6 and 12 months after implantation of the AMS 700 LGX. This prospective study consecutively enrolled men undergoing first-time IPP implant surgery from February 2009 to April 2012. Stretched flaccid penile length, penile length at 50% and 100% of stiffness (P50 and P100) and International Index of Erectile Function (IIEF) and Erectile Dysfunction Inventory of Treatment Satisfaction (EDITS) scores, were measured at 6 and 12 months postsurgery. Of 45 patients who underwent AMS 700 LGX implantation (median age 61 years) and completed 6 months' follow-up, 36 (80%) completed the study. A significant difference in stretched flaccid penile length was seen between 6 and 12 months (P = 0.033). P100 was also significantly increased at 6 and 12 months, with a mean 10% increase (1.3 ± 0.4 cm) from baseline to 12 months. Differences in mean IIEF scores at 6 and 12 months were significant for the desired domain (P = 0.0001) and for overall satisfaction (P = 0.002); however, mean EDITS scores at 6 and 12 months were not significantly improved. AMS 700 LGX is a powerful tool for preserving penile length in men undergoing penile prosthesis implantation.