LLukas22/scidocs huggingface dataset:
Long-term glycaemic control with metformin-sulphonylurea-pioglitazone triple therapy in PROactive (PROactive 17).

AIMS
We assessed the long-term glycaemic effects and the safety profile of triple therapy with the addition of pioglitazone vs. placebo in patients with Type 2 diabetes treated with combined metformin-sulphonylurea therapy in the PROspective pioglitAzone Clinical Trial In macroVascular Events (PROactive).


METHODS
In a post-hoc analysis, we identified patients treated with metformin plus sulphonylurea combination therapy and not receiving insulin at baseline (n = 1314). In those patients, we compared the effects of pioglitazone (force-titrated to 45 mg/day, n = 654) vs. placebo (n = 660) on glycated haemoglobin (HbA(1c)) reduction, concomitant changes in medications and initiation of permanent insulin use (defined as daily insulin use for a period of > or = 90 days or ongoing use at death/final visit).


RESULTS
Significantly greater reductions in HbA(1c) and greater proportions of patients with HbA(1c) at target were noted with pioglitazone vs, placebo, despite a decrease in the use of other oral glucose-lowering agents. There was an approximate twofold increase in progression to permanent insulin use in the placebo group vs. the pioglitazone group: 31.1 vs. 16.1%, respectively, when added to combination therapy. The overall safety of the metformin-sulphonylurea-pioglitazone triple therapy was good.


CONCLUSIONS
Intensifying an existing dual oral therapy regimen to a triple oral regimen by adding pioglitazone to the classical metformin-sulphonylurea combination resulted in sustained improvements in glycaemic control and reduced progression to insulin therapy. The advantages and disadvantages of adding pioglitazone instead of adding basal insulin should be assessed further.
Does the Mask Govern the Mind?: Effects of Arbitrary Gender Representation on Quantitative Task Performance in Avatar-Represented Virtual Groups

Virtual environments employing avatars for self-representation-including the opportunity to represent or misrepresent social categories-raise interesting and intriguing questions as to how one's avatar-based social category shapes social identity dynamics, particularly when stereotypes prevalent in the offline world apply to the social categories visually represented by avatars. The present experiment investigated how social category representation via avatars (i.e., graphical representations of people in computer-mediated environments) affects stereotype-relevant task performance. In particular, building on and extending the Proteus effect model, we explored whether and how stereotype lift (i.e., a performance boost caused by the awareness of a domain-specific negative stereotype associated with outgroup members) occurred in virtual group settings in which avatar-based gender representation was arbitrary. Female and male participants (N=120) were randomly assigned either a female avatar or a male avatar through a process masked as a random drawing. They were then placed in a numerical minority status with respect to virtual gender-as the only virtual female (male) in a computer-mediated triad with two opposite-gendered avatars-and performed a mental arithmetic task either competitively or cooperatively. The data revealed that participants who were arbitrarily represented by a male avatar and competed against two ostensible female avatars showed strongest performance compared to others on the arithmetic task. This pattern occurred regardless of participants' actual gender, pointing to a virtual stereotype lift effect. Additional mediation tests showed that task motivation partially mediated the effect. Theoretical and practical implications for social identity dynamics in avatar-based virtual environments are discussed.
Monitoring-based HVAC commissioning of an existing office building for energy efficiency

The performance of Heating, Ventilation and Air Conditioning (HVAC) systems may fail to satisfy design expectations due to improper equipment installation, equipment degradation, sensor failures, or incorrect control sequences. Commissioning identifies and implements cost-effective operational and maintenance measures in buildings to bring them up to the design intent or optimum operation. An existing office building is used as a case study to demonstrate the process of commissioning. Building energy benchmarking tools are applied to evaluate the energy performance for screening opportunities at the whole building level. A large natural gas saving potential was indicated by the building benchmarking results. Faulty operations in the HVAC systems, such as improper operations of air-side economizers, simultaneous heating and cooling, and ineffective optimal start, were identified through trend data analyses and functional testing. The energy saving potential for each commissioning measure is quantified with a calibrated building simulation model. An actual energy saving of 10% was realized after the implementations of cost-effective measures.
Characterizing Humour: An Exploration of Features in Humorous Texts

This paper investigates the problem of automatic humour recognition, and provides and in-depth analysis of two of the most frequently observ ed features of humorous text: human-centeredness and negative polarity. T hrough experiments performed on two collections of humorous texts, we show that th ese properties of verbal humour are consistent across different data s ets.
Privacy Protection for Telecare Medicine Information Systems Using a Chaotic Map-Based Three-Factor Authenticated Key Agreement Scheme

Telecare medicine information systems (TMIS) provide flexible and convenient e-health care. However, the medical records transmitted in TMIS are exposed to unsecured public networks, so TMIS are more vulnerable to various types of security threats and attacks. To provide privacy protection for TMIS, a secure and efficient authenticated key agreement scheme is urgently needed to protect the sensitive medical data. Recently, Mishra et al. proposed a biometrics-based authenticated key agreement scheme for TMIS by using hash function and nonce, they claimed that their scheme could eliminate the security weaknesses of Yan et al.'s scheme and provide dynamic identity protection and user anonymity. In this paper, however, we demonstrate that Mishra et al.'s scheme suffers from replay attacks, man-in-the-middle attacks and fails to provide perfect forward secrecy. To overcome the weaknesses of Mishra et al.'s scheme, we then propose a three-factor authenticated key agreement scheme to enable the patient to enjoy the remote healthcare services via TMIS with privacy protection. The chaotic map-based cryptography is employed in the proposed scheme to achieve a delicate balance of security and performance. Security analysis demonstrates that the proposed scheme resists various attacks and provides several attractive security properties. Performance evaluation shows that the proposed scheme increases efficiency in comparison with other related schemes.
The effects of annuities, bequests, and aging in an overlapping generations model of endogenous growth

We examine the effects of introducing actuarially fair annuity markets into an overlapping generations model of endogenous growth. The complete annuitisation of agents’ wealth is not, in general, dynamically optimal ; the degree of annuitisation that is dynamically optimal depends nonmonotonically on the expected length of retirement and on the pay-as-you-go social security tax rate. The government has an incentive to restrict the availability of actuarially fair annuities contracts, and can often move the economy from a pay-as-you-go to a fully-funded social security system via voluntary contributions to a government sponsored, actuarially fair pension today accompanied by reductions in social security taxes tomorrow.
AC^0 o MOD_2 Lower Bounds for the Boolean Inner Product

AC ◦ MOD2 circuits are AC circuits augmented with a layer of parity gates just above the input layer. We study AC ◦MOD2 circuit lower bounds for computing the Boolean Inner Product functions. Recent works by Servedio and Viola (ECCC TR12-144) and Akavia et al. (ITCS 2014) have highlighted this problem as a frontier problem in circuit complexity that arose both as a first step towards solving natural special cases of the matrix rigidity problem and as a candidate for constructing pseudorandom generators of minimal complexity. We give the first superlinear lower bound for the Boolean Inner Product function against AC ◦MOD2 of depth four or greater. Specifically, we prove a superlinear lower bound for circuits of arbitrary constant depth, and an Ω̃(n) lower bound for the special case of depth-4 AC ◦MOD2. Our proof of the depth-4 lower bound employs a new “moment-matching” inequality for bounded, nonnegative integer-valued random variables that may be of independent interest: we prove an optimal bound on the maximum difference between two discrete distributions’ values at 0, given that their first d moments match. ∗Simons Institute for the Theory of Computing, University of California, Berkeley, CA. Email: cheraghchi@berkeley.edu. Supported by a Qualcomm fellowship. †Department of Computer Science, Purdue University, West Lafayette, IN. Email: elena-g@purdue.edu. ‡Department of Computer Science and Engineering, Washington University, St. Louis, MO. Email: bjuba@wustl.edu. Supported by an AFOSR Young Investigator award. §Department of Mathematics, Duquesne University, Pittsburgh, PA. Email: wimmerk@duq.edu. Supported by NSF award CCF-1117079. ¶SCIS, Florida International University, Miami, FL. Email: nxie@cs.fiu.edu. Research supported in part by NSF grant 1423034.
Efficacy and safety of golimumab as add-on therapy to disease-modifying antirheumatic drugs: results of the GO-MORE study

OBJECTIVES
To evaluate the efficacy and safety of subcutaneous golimumab as add-on therapy in patients with active rheumatoid arthritis (RA) despite disease-modifying antirheumatic drug (DMARD) treatment. To evaluate an intravenous plus subcutaneous (IV+SC) golimumab strategy in patients who had not attained remission.


METHODS
GO-MORE was an open-label, multinational, prospective study in patients with active RA in typical clinical practice settings. In part 1, patients received add-on monthly 50-mg subcutaneous golimumab for 6 months. The percentage of patients with good/moderate European League Against Rheumatism (EULAR) 28-joint disease activity score (DAS28)-erythrocyte sedimentation rate (ESR) response was compared in patient subgroups with various concurrent or previous DMARD treatments. In part 2, patients with EULAR responses but not remission were randomly assigned to receive IV+SC or subcutaneous golimumab to month 12; DAS28-ESR remission was measured.


RESULTS
3366 patients were enrolled. At baseline of part 1, 3280 efficacy-evaluable patients had mean disease duration of 7.6 years and mean DAS28-ESR of 5.97 (SD=1.095). At month 6, 82.1% achieved good/moderate EULAR responses and 23.9% attained remission. When EULAR responses were analysed by the number of previously failed DMARD or the concomitant methotrexate dose, DMARD type, or corticosteroid use, no statistically significant differences were observed. Part 2 patients (N=490) who received IV+SC or subcutaneous golimumab achieved similar remission rates (∼25%). Adverse events were consistent with previous reports of golimumab and other tumour necrosis antagonists in this population.


CONCLUSIONS
Add-on monthly subcutaneous golimumab resulted in good/moderate EULAR response in most patients; 25% achieved remission after 6 more months of golimumab, but an IV+SC regimen provided no additional efficacy over the subcutaneous regimen.
Individual music therapy for depression: randomised controlled trial.

BACKGROUND
Music therapy has previously been found to be effective in the treatment of depression but the studies have been methodologically insufficient and lacking in clarity about the clinical model employed. Aims To determine the efficacy of music therapy added to standard care compared with standard care only in the treatment of depression among working-age people.


METHOD
Participants (n = 79) with an ICD-10 diagnosis of depression were randomised to receive individual music therapy plus standard care (20 bi-weekly sessions) or standard care only, and followed up at baseline, at 3 months (after intervention) and at 6 months. Clinical measures included depression, anxiety, general functioning, quality of life and alexithymia.


TRIAL REGISTRATION
ISRCTN84185937.


RESULTS
Participants receiving music therapy plus standard care showed greater improvement than those receiving standard care only in depression symptoms (mean difference 4.65, 95% CI 0.59 to 8.70), anxiety symptoms (1.82, 95% CI 0.09 to 3.55) and general functioning (-4.58, 95% CI -8.93 to -0.24) at 3-month follow-up. The response rate was significantly higher for the music therapy plus standard care group than for the standard care only group (odds ratio 2.96, 95% CI 1.01 to 9.02).


CONCLUSIONS
Individual music therapy combined with standard care is effective for depression among working-age people with depression. The results of this study along with the previous research indicate that music therapy with its specific qualities is a valuable enhancement to established treatment practices.
Intrathecal substance P-saporin in the dog: efficacy in bone cancer pain.

BACKGROUND
Substance P-saporin (SP-SAP), a chemical conjugate of substance P and a recombinant version of the ribosome-inactivating protein, saporin, when administered intrathecally, acts as a targeted neurotoxin producing selective destruction of superficial neurokinin-1 receptor-bearing cells in the spinal dorsal horn. The goal of this study was to provide proof-of-concept data that a single intrathecal injection of SP-SAP could safely provide effective pain relief in spontaneous bone cancer pain in companion (pet) dogs.


METHODS
In a single-blind, controlled study, 70 companion dogs with bone cancer pain were randomized to standard-of-care analgesic therapy alone (control, n=35) or intrathecal SP-SAP (20-60 µg) in addition to standard-of-care analgesic therapy (n=35). Activity, pain scores, and videography data were collected at baseline, 2 weeks postrandomization, and then monthly until death.


RESULTS
Although the efficacy results at the 2-week postrandomization point were equivocal, the outcomes evaluated beyond 2 weeks revealed a positive effect of SP-SAP on chronic pain management. Significantly, more dogs in the control group (74%) required unblinding and adjustment in analgesic protocol or euthanasia within 6 weeks of randomization than dogs that were treated with SP-SAP (24%; P<0.001); and overall, dogs in the control group required unblinding significantly sooner than dogs that had been treated with SP-SAP (P<0.01).


CONCLUSION
Intrathecal administration of SP-SAP in dogs with bone cancer produces a time-dependent antinociceptive effect with no evidence of development of deafferentation pain syndrome which can be seen with neurolytic therapies.
Diachronic Word Embeddings Reveal Statistical Laws of Semantic Change

Understanding how words change their meanings over time is key to models of language and cultural evolution, but historical data on meaning is scarce, making theories hard to develop and test. Word embeddings show promise as a diachronic tool, but have not been carefully evaluated. We develop a robust methodology for quantifying semantic change by evaluating word embeddings (PPMI, SVD, word2vec) against known historical changes. We then use this methodology to reveal statistical laws of semantic evolution. Using six historical corpora spanning four languages and two centuries, we propose two quantitative laws of semantic change: (i) the law of conformity—the rate of semantic change scales with an inverse power-law of word frequency; (ii) the law of innovation—independent of frequency, words that are more polysemous have higher rates of semantic change.
CLASSIFICATION OF DATA WAREHOUSE TESTING APPROACHES

Data Warehouse is a collection of large amount of data which is used by the management for making strategic decisions. The data in a data warehouse is gathered from heterogeneous sources and then populated and queried for carrying out the analysis. The data warehouse design must support the queries for which it is being used for. The design is often an iterative process and must be modified a number of times before any model can be stabilized. The design life cycle of any product includes various stages wherein, testing being the most important one. Data warehouse design has received considerable attention whereas data warehouse testing is being explored now by various researchers. This paper discusses about various categories of testing activities being carried out in a data warehouse at different levels.
Grounded theory, mixed methods, and action research.

Qualitative research includes a variety of methodological approacheswith different disciplinary origins and tools. This article discusses three commonly used approaches: grounded theory, mixed methods, and action research. It provides background for those who will encounter these methodologies in their reading rather than instructions for carrying out such research. We describe the appropriate uses, key characteristics, and features of rigour of each approach.
Au th or ' s pe rs on al co py Rough sets : Some extensions

In this article, we present some extensions of the rough set approach and we outline a challenge for the rough set based research. 2006 Elsevier Inc. All rights reserved.
Identification of an Arg-Gly-Asp (RGD) cell adhesion site in human immunodeficiency virus type 1 transactivation protein, tat

Tat, the transactivation factor of human immunodeficiency virus type 1 (HIV-1), contains the highly conserved tripeptide sequence Arg-Gly-Asp (RGD) that characterizes sites for integrin-mediated cell adhesion. The tat protein was assayed for cell attachment activity by measuring the adhesion of monocytic, T lymphocytic, and skeletal muscle-derived cell lines to tat-coated substratum. All cell lines tested bound to tat in a dose-dependent manner and the tat cell adhesion required the RGD sequence because tat mutants constructed to contain an RGE or KGE tripeptide sequence did not mediate efficient cell adhesion. The tat-mediated cell attachment also required divalent cations and an intact cytoskeleton. In addition, cell adhesion to tat was inhibited in the presence of an RGD-containing peptide GRGDSPK or an anti-tat mAb that recognizes the RGD epitope. These results strongly suggest that cells are bound to tat through an integrin. Interestingly, myoblast cells bound to tat remained round, whereas the same cells attached through an integrin for a matrix protein typically flatten and spread. The role of this RGD-dependent cellular adhesion of tat in HIV-1 infection remains to be determined.
Path following using visual odometry for a Mars rover in high-slip environments

A system for autonomous operation of Mars rovers in high slip environments has been designed, implemented, and tested. This system is composed of several key technologies that enable the rover to accurately follow a designated path, compensate for slippage, and reach intended goals independent of the terrain over which it is traversing (within the mechanical constraints of the mobility system). These technologies include: visual odometry, full vehicle kinematics, a Kalman filter pose estimator, and a slip compensation/path follower. Visual odometry tracks distinctive scene features in stereo imagery to estimate rover motion between successively acquired stereo image pairs using a maximum likelihood motion estimation algorithm. The full vehicle kinematics for a rocker-bogie suspension system estimates motion, with a no-slip assumption, by measuring wheel rates, and rocker, bogie, and steering angles. The Kalman filter merges data from an inertial measurement unit (IMU) and visual odometry. This merged estimate is then compared to the kinematic estimate to determine (taking into account estimate uncertainties) if and how much slippage has occurred. If no statistically significant slippage has occurred then the kinematic estimate is used to complement the Kalman filter estimate. If slippage has occurred then a slip vector is calculated by differencing the current Kalman filter estimate from the kinematic estimate. This slip vector is then used, in conjunction with the inverse kinematics, to determine the necessary wheel velocities and steering angles to compensate for slip and follow the desired path.
Long-term prognostic role of functional limitations among women with breast cancer.

BACKGROUND
The long-term prognostic role of functional limitations among women with breast cancer is poorly understood.


METHODS
We studied a cohort of 2202 women with breast cancer at two sites in the United States, who provided complete information on body functions involving endurance, strength, muscular range of motion, and small muscle dexterity following initial adjuvant treatment. Associations of baseline functional limitations with survival were evaluated in delayed entry Cox proportional hazards models, with adjustment for baseline sociodemographic factors, body mass index, smoking, physical activity, comorbidity, tumor characteristics, and treatment. Difference in covariates between women with and without limitations was assessed with Pearson χ(2) and Student t tests. All statistical tests were two-sided.


RESULTS
During the median follow-up of 9 years, 112 deaths were attributable to competing causes (5% of the cohort) and 157 were attributable to breast cancer causes (7% of the cohort). At least one functional limitation was present in 39% of study participants. Proportionately, more breast cancer patients with functional limitations after initial adjuvant treatment were older, less educated, and obese (P < .001). In multivariable models, functional limitations were associated with a statistically significantly increased risk of death from all causes (hazard ratio [HR] = 1.40, 95% confidence interval [CI] = 1.03 to 1.92) and from competing causes (HR = 2.60, 95% CI = 1.69 to 3.98) but not from breast cancer (HR = 0.90, 95% CI = 0.64 to 1.26). The relationship between functional limitations and overall survival differed by tumor stage (among women with stage I and stage III breast cancer, HR = 2.02, 95% CI = 1.23 to 3.32 and HR = 0.74, 95% CI = 0.42 to 1.30, respectively).


CONCLUSION
In this prospective cohort study, functional limitations following initial breast cancer treatment were associated with an important reduction in all-cause and competing-cause survival, irrespective of clinical, lifestyle, and sociodemographic factors.