LLukas22/scidocs huggingface dataset:
Primary and metastatic cardiac sarcomas: a 12-year experience at a German heart center.

BACKGROUND
Primary and metastatic cardiac sarcomas represent a heterogeneous group of rare neoplasms with varying clinical course and diverse histogenetic line of differentiation. To date, there exist no uniform guidelines for their surgical and/or oncological treatment.


METHODS
We evaluated retrospectively all patients undergoing cardiac surgery for primary or secondary cardiac sarcoma in the period 1999-2011 at the Erlangen Heart Centre to analyze their clinicopathological spectrum, treatment and outcome.


RESULTS
Five patients (3 women & 2 men; mean age: 46 years; range: 28-81 years) had primary cardiac sarcomas (6.7% of primary cardiac tumors) and 4 had cardiac metastasis from soft tissue sarcoma (1 case each of osteosarcoma, myxoid liposarcoma, alveolar soft part sarcoma and pleomorphic spindle cell sarcoma). Primary sarcomas were located in the left atrium (n=3), left ventricle (n=1) and right atrium (n=1). Histological types were myxosarcoma (3), pleomorphic undifferentiated sarcoma (1) and angiosarcoma (1). Four patients died at 2-64 months (mean, 24.5 months). Sarcoma metastasis to the heart developed at a mean of 109.5 months from initial diagnosis (range, 5-240 months). Three of them died of disease at a mean of 14 months after cardiac surgery and one is disease free 34 months after heart transplantation for metastasis.


CONCLUSIONS
Primary and metastatic cardiac sarcomas are very heterogeneous in their histological appearance, clinical presentation and course of the disease. Radical surgery combined with chemoradiation is promising in patients with resectable disease and may significantly prolong survival. Cardiac transplantation represents an emerging strategy for patients with isolated unresectable cardiac involvement.
Targeting the perivascular niche sensitizes disseminated tumour cells to chemotherapy

The presence of disseminated tumour cells (DTCs) in bone marrow is predictive of poor metastasis-free survival of patients with breast cancer with localized disease. DTCs persist in distant tissues despite systemic administration of adjuvant chemotherapy. Many assume that this is because the majority of DTCs are quiescent. Here, we challenge this notion and provide evidence that the microenvironment of DTCs protects them from chemotherapy, independent of cell cycle status. We show that chemoresistant DTCs occupy the perivascular niche (PVN) of distant tissues, where they are protected from therapy by vascular endothelium. Inhibiting integrin-mediated interactions between DTCs and the PVN, driven partly by endothelial-derived von Willebrand factor and vascular cell adhesion molecule 1, sensitizes DTCs to chemotherapy. Importantly, chemosensitization is achieved without inducing DTC proliferation or exacerbating chemotherapy-associated toxicities, and ultimately results in prevention of bone metastasis. This suggests that prefacing adjuvant therapy with integrin inhibitors is a viable clinical strategy to eradicate DTCs and prevent metastasis. Carlson et al. show that DTCs within the PVN are protected from chemotherapy; targeting interactions between DTCs and the PVN enhances chemosensitivity and prevents bone metastasis.
The boundaries of the literary archive : reclamation and representation

Contents: Introduction, Lisa Stead Part I Theorizing the Archive: The archaeology of the manuscript: towards modern palaeography, Wim Van Mierlo Allusion and exogenesis: the labouring heart of Samuel Becketta (TM)s Ill Seen Ill Said, Iain Bailey Original order, added value? Archival theory and the Douglas Coupland fonds, Jennifer Douglas. Part II Reclamation and Representation: Untrustworthy reproductions and doctored archives: undoing the sins of a Victorian biographer, Isabelle Cosgrave The double life of a "the ghost in the garden rooma (TM): Charles Dickens edits Elizabeth Gaskell, Fran Baker Lost property: John Galsworthy and the search for a "that stuffed shirta (TM), Simon Barker Poetry and personality: the private papers and public image of Elizabeth Jennings, Jane Dowson. Part III Boundaries: Illustration and ekphrasis: the working drafts of Ted Hughesa (TM)s Cave Birds, Carrie Smith Letter writing, cinemagoing and archive ephemera, Lisa Stead. Part IV Working in the Archive: To reveal or conceal: privacy and confidentiality in the papers of contemporary authors, Sara S. Hodson Teaching the material archive at Smith College, Karen V. Kukil a "What will survive of us are manuscriptsa (TM): archives, scholarship and human stories, Helen Taylor Index.
Universal Learning of Repeated Matrix Games

We study and compare the learning dynamics of two universal learning algorithms, one based on Bayesian learning and the other on prediction with expert advice. Both approaches have strong asymptotic performance guarantees. When confronted with the task of finding good long-term strategies in repeated 2x2 matrix games, they behave quite differently.
Anonymous Authentication Scheme based on NTRU for the Protection of Payment Information in NFC Mobile Environment

Recently, smart devices for various services have been developed using converged telecommunications, and the markets for near field communication mobile services is expected to grow rapidly. In particular, the realization of mobile NFC payment services is expected to go commercial, and it is widely attracting attention both on a domestic and global level. However, this realization would increase privacy infringement, as personal information is extensively used in the NFC technology. One example of such privacy infringement would be the case of the Google wallet service. In this paper, we propose an zero-knowledge proof scheme and ring signature based on NTRU for protecting user information in NFC mobile payment systems without directly using private financial information of the user. Keywords—NFC Mobile Payment, Zero Knowledge Proof, NTRU, Ring Signature
Trends in smoking cessation counseling: experience from American Heart Association-get with the guidelines.

BACKGROUND
Successful smoking cessation in stroke and coronary artery disease (CAD) patients is important, as smoking contributes to significant morbidity and mortality. The American Heart Association developed Get With The Guidelines (GWTG) to improve compliance with national guideline recommendations for cardiovascular care. Using data from GWTG, we examined trends associated with the smoking-cessation counseling (SCC) performance measure.


HYPOTHESIS
Implementation of a systematic quality improvement program will increase compliance with the SCC performance measure.


METHODS
We evaluated compliance with SCC in current or recent smokers identified from 224 671 CAD admissions between 2002 and 2008 in the GWTG-CAD database, and from 405 681 stroke admissions between 2002 and 2007 in the GWTG-Stroke database. Additionally, we examined adherence to other performance and quality measures related to CAD and stroke care.


RESULTS
Overall, 55 904 GWTG-CAD and 58 865 GWTG-Stroke admissions were used for the analysis. Rates of SCC improved in each successive year during the study, from 67.6% to 97.4% (P < 0.001) in GWTG-CAD and from 40.1% to 90.7% (P < 0.001) in GWTG-Stroke. Compliance with SCC was up to 34.7% lower (P < 0.0001) in GWTG-Stroke compared with GWTG-CAD, but this difference decreased to 6.7% (P < 0.0001) by the end of the study period. Compliance with many other performance and quality measures was significantly lower among patients not receiving SCC.


CONCLUSIONS
Get With The Guidelines has improved compliance with the SCC performance measure among patients with CAD and stroke. Although the initial disparity in rates of SCC between CAD and stroke patients gradually improved, the difference remained significant.
Complex Inhibitory Effects of Nitric Oxide on Autophagy

Autophagy, a major degradation process for long-lived and aggregate-prone proteins, affects various human processes, such as development, immunity, cancer, and neurodegeneration. Several autophagy regulators have been identified in recent years. Here we show that nitric oxide (NO), a potent cellular messenger, inhibits autophagosome synthesis via a number of mechanisms. NO impairs autophagy by inhibiting the activity of S-nitrosylation substrates, JNK1 and IKKβ. Inhibition of JNK1 by NO reduces Bcl-2 phosphorylation and increases the Bcl-2-Beclin 1 interaction, thereby disrupting hVps34/Beclin 1 complex formation. Additionally, NO inhibits IKKβ and reduces AMPK phosphorylation, leading to mTORC1 activation via TSC2. Overexpression of nNOS, iNOS, or eNOS impairs autophagosome formation primarily via the JNK1-Bcl-2 pathway. Conversely, NOS inhibition enhances the clearance of autophagic substrates and reduces neurodegeneration in models of Huntington's disease. Our data suggest that nitrosative stress-mediated protein aggregation in neurodegenerative diseases may be, in part, due to autophagy inhibition.
Axiomatic Foundations of the Universal Integral in Terms of Aggregation Functions and Preference Relations

The concept of universal integral has been recently proposed in order to generalize the Choquet, Shilkret and Sugeno integrals. We present two axiomatic foundations of the universal integral. The first axiomatization is expressed in terms of aggregation functions, while the second is expressed in terms of preference relations.
Treatment of Major Depressive Disorder with Iyengar Yoga and Coherent Breathing: A Randomized Controlled Dosing Study

OBJECTIVES
The aims of this study were to assess the effects of an intervention of Iyengar yoga and coherent breathing at five breaths per minute on depressive symptoms and to determine optimal intervention yoga dosing for future studies in individuals with major depressive disorder (MDD).


METHODS
Subjects were randomized to the high-dose group (HDG) or low-dose group (LDG) for a 12-week intervention of three or two intervention classes per week, respectively. Eligible subjects were 18-64 years old with MDD, had baseline Beck Depression Inventory-II (BDI-II) scores ≥14, and were either on no antidepressant medications or on a stable dose of antidepressants for ≥3 months. The intervention included 90-min classes plus homework. Outcome measures were BDI-II scores and intervention compliance.


RESULTS
Fifteen HDG (Mage = 38.4 ± 15.1 years) and 15 LDG (Mage = 34.7 ± 10.4 years) subjects completed the intervention. BDI-II scores at screening and compliance did not differ between groups (p = 0.26). BDI-II scores declined significantly from screening (24.6 ± 1.7) to week 12 (6.0 ± 3.8) for the HDG (-18.6 ± 6.6; p < 0.001), and from screening (27.7 ± 2.1) to week 12 (10.1 ± 7.9) in the LDG (-17.7 ± 9.3; p < 0.001). There were no significant differences between groups, based on response (i.e., >50% decrease in BDI-II scores; p = 0.65) for the HDG (13/15 subjects) and LDG (11/15 subjects) or remission (i.e., number of subjects with BDI-II scores <14; p = 1.00) for the HDG (14/15 subjects) and LDG (13/15 subjects) after the 12-week intervention, although a greater number of subjects in the HDG had 12-week BDI-II scores ≤10 (p = 0.04).


CONCLUSION
During this 12-week intervention of yoga plus coherent breathing, depressive symptoms declined significantly in patients with MDD in both the HDG and LDG. Both groups showed comparable compliance and clinical improvements, with more subjects in the HDG exhibiting BDI-II scores ≤10 at week 12.
The Portable Document Format - PDF

This article demonstrates how documents prepared in hypertext or word processor format can be saved in portable document format (PDF). These files are self-contained documents that that have the same appearance on screen and in print, regardless of what kind of computer or printer are used, and regardless of what software package was originally used to for their creation. PDF files are compressed documents, invariably smaller than the original files, hence allowing rapid dissemination and download.
Parametrization and smooth approximation of surface triangulations

A method based on graph theory is investigated for creating global parametrizations for surface triangulations for the purpose of smooth surface fitting. The parametrizations, which are planar triangulations, are the solutions of linear systems based on convex combinations. A particular parametrization, called shape-preserving, is found to lead to visually smooth surface approximations.
Keto acid-supplemented low-protein diet for treatment of adult patients with hepatitis B virus infection and chronic glomerulonephritis.

OBJECTIVES
An open-label, randomized, controlled, single-centre clinical trial to evaluate the effects of low-protein intake, with or without keto acid supplementation, on nutritional status and proteinuria, in patients with hepatitis B virus (HBV) and early stage chronic glomerulonephritis.


METHODS
Patients with chronic glomerulonephritis and HBV infection were randomized to receive a low-protein diet (0.6-0.8 g/kg ideal body weight [IBW] per day) either without (LP group) or with (sLP group) keto acid supplementation (0.1 g/kg IBW per day), for 12 months. Nutritional, clinical and safety parameters were recorded.


RESULTS
The study included 17 patients (LP group n = 9; sLP group n = 8). Proteinuria and microalbuminuria were significantly lower in the sLP group at 6 and 12 months compared with baseline, and at 12 months compared with the LP group. There were no significant differences in serum creatinine level or estimated glomerular filtration rate. Nutritional parameters (serum albumin and prealbumin) were significantly improved at 12 months, compared with baseline, in the sLP group.


CONCLUSIONS
Restriction of dietary protein intake to 0.6-0.8 g/kg IBW per day appears to have an acceptable safety profile. Supplementation with keto acids is associated with decreased urine protein excretion.
Exploring Think-Alouds in Usability Testing: An International Survey

Research problem: The study explored think-aloud methods usage within usability testing by examining the following questions: How, and why is the think-aloud method used? What is the gap between theory and practice? Where does this gap occur? Literature review: The review informed the survey design. Usability research based on field studies and empirical tests indicates that variations in think-aloud procedures may reduce test reliability. The guidance offered on think-aloud procedures within a number of handbooks on usability testing is also mixed. This indicates potential variability in practice, but how much and for what reasons is unknown. Methodology: An exploratory, qualitative survey was conducted using a web-based questionnaire (during November-December 2010). Usability evaluators were sought via emails (sent to personal contacts, usability companies, conference attendees, and special interest groups) to be cascaded to the international community. As a result we received 207 full responses. Descriptive statistics and thematic coding were used to analyze the data sets. Results: Respondents found the concurrent technique particularly suited usability testing as it was fast, easy for users to relate to, and requires limited resources. Divergent practice was reported in terms of think-aloud instructions, practice, interventions, and the use of demonstrations. A range of interventions was used to better understand participant actions and verbalizations, however, respondents were aware of potential threats to test reliability, and took steps to reduce this impact. Implications: The reliability considerations underpinning the classic think-aloud approach are pragmatically balanced against the need to capture useful data in the time available. A limitation of the study is the focus on the concurrent method; other methods were explored but the differences in application were not considered. Future work is needed to explore the impact of divergent use of think-aloud instructions, practice tasks, and the use of demonstrations on test reliability.
The Crystal Proteins from Bacillus thuringiensis subsp. thompsoni Display a Synergistic Activity Against the Codling Moth, Cydia pomonella

Crystal proteins from Bacillus thuringiensis subsp. thompsoni strain HnC are active against the codling moth, Cydia pomonella, a major pest of orchards. Inclusion bodies purified from strain HnC displayed an LC50 of 3.34 × 10−3μg/μl. HnC-purified crystals were tenfold more active than Cry2Aa and Cry1Aa toxins, and 100-fold more toxic than Cry1Ab. The 34-kDa and 40-kDa proteins contained in HnC inclusion bodies were shown to act synergistically. The toxicity of crystal proteins produced by the recombinant B. thuringiensis strain BT-OP expressing the full-length native operon was about tenfold higher than that of the 34-kDa protein. When the gene encoding the non-insecticidal 40-kDa protein, which is not active, was introduced into the recombinant strain producing only the 34-kDa protein, the toxicity was raised tenfold and was similar to that of the strain BT-OP.
Do hypertensive patients’ beliefs about their illness and treatment influence medication adherence and quality of life?

Do hypertensive patients’ beliefs about their illness and treatment influence medication adherence and quality of life?
Radiofrequency Volumetric Reduction for Masseteric Hypertrophy

Masseteric hypertrophy occurs frequently among Asians, including Koreans, because of racial characteristics and dietary habits. It is thought to be an unpleasant feature, especially because of its strong and masculine impression. Recently, the authors developed a method for the volumetric reduction of hypertrophied masseter muscles using radiofrequency energy to correct the squared facial appearance caused by the hypertrophy. This study was performed to investigate the effects of radiofrequency applied to reduce hypertrophied masseter muscles of patients who sought an aesthetic alternative for a slim, smooth, and feminine-looking lower facial contour. A total of 340 patients were treated. The patients usually recognized the volume change 3 to 6 weeks after treatment, and an objective volume reduction was observed within 3 months of the operation. The range of the reduction in the masseter thickness, as measured by ultrasonic examination at a 6-month postoperative follow-up visit, was 10% to 60% (mean, 27%). Most of the patients could eat a nearly normal diet after 4 weeks and were satisfied with the improved aesthetic contour lines of their lower face. Radiofrequency-induced coagulation tissue necrosis of the masseter did not cause any infections or limitations of mouth opening, and the clinical improvement was well maintained after the treatment.
Toward whole-session relevance: exploring intrinsic diversity in web search

Current research on web search has focused on optimizing and evaluating single queries. However, a significant fraction of user queries are part of more complex tasks [20] which span multiple queries across one or more search sessions [26,24]. An ideal search engine would not only retrieve relevant results for a user's particular query but also be able to identify when the user is engaged in a more complex task and aid the user in completing that task [29,1]. Toward optimizing whole-session or task relevance, we characterize and address the problem of intrinsic diversity (ID) in retrieval [30], a type of complex task that requires multiple interactions with current search engines. Unlike existing work on extrinsic diversity [30] that deals with ambiguity in intent across multiple users, ID queries often have little ambiguity in intent but seek content covering a variety of aspects on a shared theme. In such scenarios, the underlying needs are typically exploratory, comparative, or breadth-oriented in nature. We identify and address three key problems for ID retrieval: identifying authentic examples of ID tasks from post-hoc analysis of behavioral signals in search logs; learning to identify initiator queries that mark the start of an ID search task; and given an initiator query, predicting which content to prefetch and rank.
Driver Behavior and Situation Aware Brake Assistance for Intelligent Vehicles

This paper deals with the development of Human-Centric Intelligent Driver Assistance Systems. Rear-end collisions account for a large portion of traffic accidents. To help mitigate this problem, predictive braking systems and adaptive cruise control systems have been developed. However, these types of systems usually rely solely on the vehicle and vehicle surround sensors, either ignoring the human component of driving or learning the driver's control behavior using only these sensors. As with all human-computer interfaces, this has the potential to work against the driver, distract the driver further, or even annoy the driver so that the driver ignores or disables the system. It is, therefore, important to directly take the driver's intended actions into account when designing a driver assistance system. By using a probabilistic model for the system, warnings and preventative measures can be constructed based on varying levels of situational severity and driver attentiveness and intent. The research is based upon carefully conducted experimental trials involving a human subjects driving in natural manner and on typical freeways in the USA. The experiments, designed by inputs from cognitive scientist, were conducted in a specially designed instrumented vehicle to record important cues associated with driver's behavior, vehicle state, and vehicle surround in a synchronized manner. Quantitative results and analysis of the experimental trials are presented to show the feasibility and promise of this framework to predict the driver's intent to brake, the need for braking given the current situation, and at what level the driver should be warned
Current European data collection on emergency department presentations with acute recreational drug toxicity: gaps and national variations.

BACKGROUND
The number of new (novel) psychoactive substances (NPS) available in the illegal market is increasing; however, current monitoring of the drug situation in Europe focuses mainly on classical drugs of abuse, with limited emphasis on clinical presentation in the emergency department (ED). The European Drug Emergencies Network (Euro-DEN) is a European Commission-funded project that aims to improve the knowledge of acute drug toxicity of both classical recreational drugs and NPS. As a baseline for this project, we performed a study to establish which data are currently being collected and reported in Europe on ED presentations with acute toxicity related to NPS and classical drugs of abuse.


METHODS
We used a three-pronged approach to identify any systematic collection of data on NPS toxicity in Europe by i) performing a literature search, ii) utilising an online survey of the European Monitoring Centre for Drugs and Drug Addiction Re seau Europe en d'Information sur les Drogues et les Toxicomanies national focal points and iii) exploiting the knowledge and resources of the Euro-DEN network members.


RESULTS
The literature search revealed 21 papers appropriate for assessment, but only one described a systematic collection of clinical data on NPS. Twenty-seven of thirty countries responded to the online survey. More than half of all the countries (52%) did not perform any registration at all of such data, 37% collected systematic clinical data on NPS at a national level, while 44% collected data on classical drugs. A few examples for good practice of systematic collection of clinical data on ED presentations due to acute toxicity were identified.


CONCLUSION
The systematic collection of data on ED presentation of toxicity related to NPS and classical drugs in Europe is scarce; the existing collection is limited to single centres, single countries, groups of patients or not focused on novel drugs; the collection of data is highly variable between the different countries. Euro-DEN, a European Commission funded project, aims at closing some of these gaps.