LLukas22/scidocs huggingface dataset:
Effect of Nutrition Supplementation in Children Living with HIV at ART Centre.

OBJECTIVE
To assess the benefits of nutrition supplementation in children living with HIV (CLHIV).


METHODS
A prospective observational study was carried out at antiretroviral therapy (ART)/pediatric centre of excellence (PCOE), Niloufer hospital for a period of one year in CLHIV (N = 164) aged 1 to 18 y referred to ART/PCOE. Nutrition supplementation was given in the form of Ready to Use Food (About 350 kcal and 12 g of protein per day) supplementation to assess improvement in Height for age Z (HAZ), Weight for Age Z (WAZ), Weight for Height Z (WHZ) and Body Mass Index for age Z (BMIZ) scores over a period of one year.


RESULTS
At baseline, 65.5 % and 57.5 % of children below and above 5 y respectively were stunted. 24.1 % and 45.3 % children below and above 5 y respectively were wasted/thin (as assessed by BMI for age). Mean BMIZ score significantly improved in both the age groups (0.96 Z score, P < 0.001) in below and above 5 (0.37 Z score, P < 0.001) respectively at the end of 12 mo. Mean HAZ score also significantly improved in children above 5 y (0.09 Z score, P < 0.05) with non-significant improvement below 5 y (0.14 Z score, P < 0.57) by the end of 12 mo.


CONCLUSIONS
Nutrition supplementation over one year resulted in moderate improvement in the nutritional status of CLHIV. However, it is unclear, whether the improvement in nutritional status was due to regular visits to ART centre that may have resulted in better adherence to treatment or an additional benefit of nutrition intervention. This warrants a well-designed randomized controlled trial to examine the benefits of nutrition supplementation in CLHIV attending ART centre.
Merkle-Damgård Revisited: How to Construct a Hash Function

The most common way of constructing a hash function (e.g., SHA-1) is to iterate a compression function on the input message. The compression function is usually designed from scratch or made out of a blockcipher. In this paper, we introduce a new security notion for hash-functions, stronger than collisionresistance. Under this notion, the arbitrary length hash function H must behave as a random oracle when the fixed-length building block is viewed as a random oracle or an ideal block-cipher. The key property is that if a particular construction meets this definition, then any cryptosystem proven secure assuming H is a random oracle remains secure if one plugs in this construction (still assuming that the underlying fixedlength primitive is ideal). In this paper, we show that the current design principle behind hash functions such as SHA-1 and MD5 — the (strengthened) Merkle-Damg̊ard transformation — does not satisfy this security notion. We provide several constructions that provably satisfy this notion; those new constructions introduce minimal changes to the plain Merkle-Damg̊ard construction and are easily implementable in practice. University of Luxembourg, Email: coron@clipper.ens.fr New York University, Email: dodis@cs.nyu.edu Gemplus Card International, Email: cecile.malinaud@normalesup.org New York University, Email: puniya@cs.nyu.edu
Effects of drought on water content and photosynthetic parameters in potato plants expressing the trehalose-6-phosphate synthase gene of Saccharomyces cerevisiae

Two transgenic potato lines, T1 and T2, expressing the trehalose-6-phosphate synthase (TPS1) gene of yeast were isolated. In our experimental approach, we applied two novelties, namely the fusion of the drought-inducible promoter StDS2 to TPS1 and a marker-free transformation method. In contrast to the expected drought-induced expression, only a very low constitutive TPS1 expression was detected in the transgenic lines, probably due to chromosomal position effects. The observed expression pattern, however, was sufficient to alter the drought response of plants. Detached leaves of T1 and T2 showed an 8 h delay in wilting compared to the non-transformed control. Potted plants of T1 and T2 kept water 6 days longer than control plants and maintained high stomatal conductance and a satisfactory rate of net photosynthesis. During drought treatment, CO2 assimilation rate measured at saturating CO2 level was maintained at maximum level for 6–9 days in transgenic plants while it decreased rapidly after 3 days in the wild type plants. Under optimal growth conditions, lower CO2 fixation was detected in the transgenic than in the control plants. Stomatal densities of T1 and T2 leaves were reduced by 30–40%. This may have contributed to the lower CO2 fixation rate and altered drought response.
PRISM-games: A Model Checker for Stochastic Multi-Player Games

Abstract. We present PRISM-games, a model checker for stochastic multi-player games, which supports modelling, automated verification and strategy synthesis for probabilistic systems with competitive or cooperative behaviour. Models are described in a probabilistic extension of the Reactive Modules language and properties are expressed using rPATL, which extends the well-known logic ATL with operators to reason about probabilities, various reward-based measures, quantitative properties and precise bounds. The tool is based on the probabilistic model checker PRISM, benefiting from its existing user interface and simulator, whilst adding novel model checking algorithms for stochastic games, as well as functionality to synthesise optimal player strategies, explore or export them, and verify other properties under the specified strategy.
Online dating system design and relational decision making : Choice , algorithms , and control

One of the most popular ways to initiate romantic relationships today is through online dating. Typical dating systems follow one of three formats, see-and-screen (e.g., Match.com), algorithm (e.g., eHarmony.com), and blended (e.g., OkCupid.com), which differ in the amount of individual control and algorithmic involvement they offer users. Do different features affect daters’ decisions and expectations regarding relational development with selected partners? Study 1 indicated that although daters appreciated the personal control over mate selection afforded by see-and-screen systems, they also enjoyed using algorithmic systems. Study 2 found that blended systems provided “the best of both worlds” by offering dual benefits of control and algorithmic validation during mate selection. Findings shed light on self-determination theory, decision making, and relationship formation more broadly. Since its inception in the early 2000s, online dating has shed its stigma to become an important part of the current landscape of romantic relationship formation. Indeed, recent statistics indicate approximately 30 million online Americans have turned to online dating as a way to initiate romantic relationships (Smith & Duggan, 2013). A growing body of research has examined daters’ behaviors at “micro” levels such as self-presentation and impression formation in dating profiles (e.g., Ellison, Heino, & Gibbs, 2006) and at “macro” Stephanie T. Tong, Department of Communication, Wayne State University; Jeffrey T. Hancock, Department of Communication, Stanford University; Richard B. Slatcher, Department of Psychology, Wayne State University. This work was supported by NSF Grant 1520723. Portions of this paper were presented at the 2016 Human Computer Interaction International Conference in Toronto, ON. The authors thank four anonymous reviewers and the associate editor, Edward Lemay, for their suggestions on previous versions of this work. The authors are grateful to Elena Corriero, Chad Van De Wiele, Benjamin Lennemann, Annisa Rochadiat, and Prathyusha Tadi for their help with data collection. Correspondence should be addressed to Stephanie T. Tong, Wayne State University, Department of Communication, 569 Manoogian Hall, Detroit, MI 48201, e-mail: stephanie.tong@wayne.edu. levels such as attraction through race (Lin & Lundquist, 2013; Rudder, 2014). But few existing studies have explored how the design of the dating technologies themselves may directly influence daters’ perceptions and relational
Juvenile hepatocellular carcinoma with congestive liver cirrhosis

A case of juvenile hepatocellular carcinoma (HCC) with congestive liver cirrhosis is reported. The patient was a 21-year-old woman. She had been diagnosed as having transposition of the great arteries, type 2, in 1978. She underwent the Mustard operation, but suffered from chronic heart failure. In 1995, she experienced abdominal pain and underwent examination. The laboratory data were normal, except for elevated total bilirubin (5.2 mg/dl). Blood examinations were performed at frequent intervals, and the total bilirubin level fluctuated between 0.9 and 8.1 mg/dl over the next 4 years, but the transaminase level remained normal. In 1999, she experienced abdominal pain again and was admitted to our hospital. Computed tomography showed four space-occupying lesions in the liver; 45 mm, 20 mm, 12 mm, and 10 mm in size. She was diagnosed as having HCC, and transcatheter arterial chemoembolization and percutaneous ethanol injection therapy were performed. Histology of the cancerous and the noncancerous liver tissue revealed HCC, moderately differentiated type, in cirrhotic liver with congestion. This patient had no background factors of liver disease, except for liver congestion, associated with the chronic heart failure. Because most patients with cardiac cirrhosis die of cardiac disease, only a small number of these patients develop liver failure. However, the incidence of HCC in patients with congestive liver disease is likely to increase in the future, as survival time is prolonged with the advances in treatment for chronic heart failure. Therefore, patients with congestive liver disease should be followed, taking into account the possibility of HCC.
Building an Encrypted and Searchable Audit Log

Audit logs are an important part of any secure system, and they need to be carefully designed in order to give a faithful representation of past system activity. This is especially true in the presence of adversaries who might want to tamper with the audit logs. While it is important that auditors can inspect audit logs to assess past system activity, the content of an audit log may contain sensitive information, and should therefore be protected from unauthorized
Anatomical reconstruction of the lateral ligaments of the ankle with semitendinosus allograft

The purpose of our study is to evaluate the clinical results of anatomical reconstruction of the lateral ligaments with semitendinosus allograft. Thirty-six patients with chronic lateral instability underwent anatomical reconstruction of the lateral ligaments of the ankle with semitendinosus allograft. The American Orthopaedic Foot and Ankle Society Ankle-Hindfoot Scale score (AOFAS score) and the Karlsson score were used to evaluate the clinical results before and after surgery. A total of 35 patients (97.2 %) (36 ankles) were followed up for a mean of 37.9 months. The mean AOFAS score improved from 42.3 ± 4.9 points preoperatively to 90.4 ± 6.7 postoperatively. The mean Karlsson score improved from 38.5 ± 3.2 preoperatively to 90.1 ± 7.8 postoperatively. Anatomical reconstruction of the lateral ligaments with semitendinosus allograft achieves a satisfactory surgical outcome for chronic ankle instability.
Effect of a gel containing pilocarpine on vaginal atrophy in castrated rats

OBJECTIVES
To evaluate the effect of Carbopol gel formulations containing pilocarpine on the morphology and morphometry of the vaginal epithelium of castrated rats.


METHODS
Thirty-one female Wistar-Hannover rats were randomly divided into four groups: the control Groups I (n=7, rats in persistent estrus; positive controls) and II (n=7, castrated rats, negative controls) and the experimental Groups, III (n=8) and IV (n=9). Persistent estrus (Group I) was achieved with a subcutaneous injection of testosterone propionate on the second postnatal day. At 90 days postnatal, rats in Groups II, III and IV were castrated and treated vaginally for 14 days with Carbopol gel (vehicle alone) or Carbopol gel containing 5% and 15% pilocarpine, respectively. Next, all of the animals were euthanized and their vaginas were removed for histological evaluation. A non-parametric test with a weighted linear regression model was used for data analysis (p<0.05).


RESULTS
The morphological evaluation showed maturation of the vaginal epithelium with keratinization in Group I, whereas signs of vaginal atrophy were present in the rats of the other groups. Morphometric examinations showed mean thickness values of the vaginal epithelium of 195.10±12.23 μm, 30.90±1.14 μm, 28.16±2.98 μm and 29.84±2.30 μm in Groups I, II, III and IV, respectively, with statistically significant differences between Group I and the other three groups (p<0.0001) and no differences between Groups II, III and IV (p=0.0809).


CONCLUSION
Topical gel formulations containing pilocarpine had no effect on atrophy of the vaginal epithelium in the castrated female rats.
RAINDROP SIZE DISTRIBUTION MODELING FOR RADIO LINK DESIGN ALONG THE EASTERN COAST OF SOUTH AFRICA

A study of the raindrop size distribution along the eastern coast of South Africa (Durban) is presented. The Biweight kernel estimator based on distometer measurement is used to determine the best estimate of the measured raindrop size probability distribution function (pdf). The best kernel estimator, which results in the lowest integral square error (ISE), is used to measure the closeness of the estimated lognormal and gamma pdf of raindrop size to the measured raindrop size distribution. It is established that the optimised lognormal pdf slightly outperforms the optimised gamma pdf in terms of the mean ISE and the RMSE values, with mean ISE values of 0.026 for lognormal and 0.04 for gamma distributions, respectively, and corresponding mean RMSE values of 0.073 and 0.081, respectively. The method-of-moments gamma and lognormal distributions are observed to be worse estimators of the measured pdf than the two optimized distributions. The N(D) distributions using the optimised lognormal and gamma distributions for the region are compared with those for different tropical regions, namely, India, Singapore, Nigeria, Indonesia, and Brazil. While the Indian lognormal N(D) model gives the highest peak for low raindrop sizes for all rain rates, Durban’s gamma and lognormal models exhibit the widest raindrop size spread over all rain rates ranging from 1–120 mm/h. Finally, the specific attenuation due to rain using the Durban models are compared against the ITU-R models and actual measurements over a 19.5GHz LOS link; the results indicate a need for further work involving both distrometer and radio link measurements for rain rates exceeding 30mm/h in the eastern coast of South Africa. Received 20 August 2011, Accepted 28 September 2011, Scheduled 2 October 2011 * Corresponding author: Thomas J. O. Afullo (afullot@ukzn.ac.za).
hdbscan: Hierarchical density based clustering

HDBSCAN: Hierarchical Density-Based Spatial Clustering of Applications with Noise (Campello, Moulavi, and Sander 2013), (Campello et al. 2015). Performs DBSCAN over varying epsilon values and integrates the result to find a clustering that gives the best stability over epsilon. This allows HDBSCAN to find clusters of varying densities (unlike DBSCAN), and be more robust to parameter selection. The library also includes support for Robust Single Linkage clustering (Chaudhuri et al. 2014), (Chaudhuri and Dasgupta 2010), GLOSH outlier detection (Campello et al. 2015), and tools for visualizing and exploring cluster structures. Finally support for prediction and soft clustering is also available.
Lenalidomide in combination with dexamethasone for the treatment of multiple myeloma after one prior therapy.

PURPOSE
Lenalidomide (CC-5013, Revlimid; Celgene Corporation, Summit, NJ), a thalidomide analogue, was granted approval by the U.S. Food and Drug Administration (FDA) on June 29, 2006, for use in combination with dexamethasone in patients with multiple myeloma (MM) who have received at least one prior therapy. The FDA approved lenalidomide with a restricted distribution program, RevAssist.


EXPERIMENTAL DESIGN
In two randomized, double-blind, multicenter studies, the combination of lenalidomide and dexamethasone (LD) was compared with placebo and dexamethasone (PD) in patients with MM who had received at least one prior therapy. The primary endpoint was time to progression (TTP).


RESULTS
Following a prespecified interim analysis of TTP, an independent data-monitoring committee advised the sponsor to halt the two studies. For both studies, the interim analysis for efficacy revealed a statistically significant longer TTP with LD than with PD. The most clinically relevant grade 3 and 4 adverse events that occurred more frequently in the LD arm were neutropenia, thrombocytopenia, deep vein thrombosis, pulmonary embolism, and atrial fibrillation. Thrombotic or thromboembolic events, including deep vein thrombosis, pulmonary embolism, thrombosis, and intracranial venous sinus thrombosis were reported more frequently in patients treated with LD than with PD.


CONCLUSIONS
The FDA approved lenalidomide based on interim results from two multicenter, placebo-controlled, randomized trials comparing the combination of LD with PD that revealed a longer TTP with LD than with PD. The major toxicity observed during these trials was myelosuppression. The serious toxicities included thromboembolic events. Lenalidomide is only available under the RevAssist Program.
A better understanding of harmonic distortion in the petrochemical industry

This paper provides an in-depth discussion on harmonic distortion on power systems in the petrochemical industry. The paper begins with a discussion on harmonics caused by saturable magnetic devices such as generators, transformers, and motors. Production and control of harmonic voltages and currents produced in these devices will be covered. Then, a discussion on the production and control of harmonic voltages and currents produced by power electronic devices will be discussed. An example of power system harmonics and harmonic suppression techniques will be presented.
The Royal Free Hospital Score: A Calibrated Prognostic Model for Patients With Cirrhosis Admitted to Intensive Care Unit. Comparison With Current Models and CLIF-SOFA Score

OBJECTIVES:Prognosis for patients with cirrhosis admitted to intensive care unit (ICU) is poor. ICU prognostic models are more accurate than liver-specific models. We identified predictors of mortality, developed a novel prognostic score (Royal Free Hospital (RFH) score), and tested it against established prognostic models and the yet unvalidated Chronic Liver Failure-Sequential Organ Failure Assessment (CLIF-SOFA) model.METHODS:Predictors of mortality were defined by logistic regression in a cohort of 635 consecutive patients with cirrhosis admitted to ICU (1989–2012). The RFH score was derived using a 75% training and 25% validation set. Predictive accuracy and calibration were evaluated using area under the receiver operating characteristic (AUROC) and goodness-of-fit χ2 for the RFH score, as well as for SOFA, Model for End-Stage Liver Disease (MELD), Acute Physiology and Chronic Health Evaluation (APACHE II), and Child-Pugh. CLIF-SOFA was applied to a recent subset (2005–2012) of patients.RESULTS:In-hospital mortality was 52.3%. Mortality improved over time but with a corresponding reduction in acuity of illness on admission. Predictors of mortality in training set, which constituted the RFH score, were the following: bilirubin, international normalized ratio, lactate, alveolar arterial partial pressure oxygen gradient, urea, while variceal bleeding as indication for admission conferred lesser risk. Classification accuracy was 73.4% in training and 76.7% in validation sample and did not change significantly across different eras of admission. The AUROC for the derived model was 0.83 and the goodness-of-fit χ2 was 3.74 (P=0.88). AUROC for SOFA was 0.81, MELD was 0.79, APACHE II was 0.78, and Child-Pugh was 0.67. In 2005–2012 cohort, AUROC was: SOFA: 0.74, CLIF-SOFA: 0.75, and RFH: 0.78. Goodness-of-fit χ2 was: SOFA: 6.21 (P=0.63), CLIF-SOFA: 9.18 (P=0.33), and RFH: 2.91 (P=0.94).CONCLUSIONS:RFH score demonstrated good discriminative ability and calibration. Internal validation supports its generalizability. CLIF-SOFA did not perform better than RFH and the original SOFA. External validation of our model should be undertaken to confirm its clinical utility.
Formulation and Evaluation of Fast Dissolving Films for Delivery of Triclosan to the Oral Cavity

The present investigation was undertaken with the objective of formulating TC containing fast dissolving films for local delivery to oral cavity. Various film forming agents, film modifiers and polyhydric alcohols were evaluated for optimizing the composition of fast dissolving films. The potential of poloxamer 407 and hydroxypropyl-β- cyclodextrin (HPBCD) to improve solubility of TC was investigated. Fast dissolving films containing hydroxypropyl methylcellulose (HPMC), xanthan gum, and xylitol were formulated. Use of poloxamer 407 and HPBCD resulted in significant improvement in the solubility of TC. Fast dissolving films containing TC-HPBCD complex and TC-Poloxamer 407 were formulated and were evaluated for the in vitro dissolution profile and in vitro microbiological assay. Films containing TC-Poloxamer 407 exhibited better in vitro dissolution profile and in vitro antimicrobial activity as compared to the films containing TC-HPBCD complex. Effect of incorporation of eugenol on the in vivo performance of TC-Poloxamer 407 containing films was evaluated in human volunteers. Eugenol containing films improved the acceptability of TC-Poloxamer 407 films with respect to taste masking and mouth freshening without compromising the in vivo dissolution time.
Efficient organic carbon burial in the Bengal fan sustained by the Himalayan erosional system

Continental erosion controls atmospheric carbon dioxide levels on geological timescales through silicate weathering, riverine transport and subsequent burial of organic carbon in oceanic sediments. The efficiency of organic carbon deposition in sedimentary basins is however limited by the organic carbon load capacity of the sediments and organic carbon oxidation in continental margins. At the global scale, previous studies have suggested that about 70 per cent of riverine organic carbon is returned to the atmosphere, such as in the Amazon basin. Here we present a comprehensive organic carbon budget for the Himalayan erosional system, including source rocks, river sediments and marine sediments buried in the Bengal fan. We show that organic carbon export is controlled by sediment properties, and that oxidative loss is negligible during transport and deposition to the ocean. Our results indicate that 70 to 85 per cent of the organic carbon is recent organic matter captured during transport, which serves as a net sink for atmospheric carbon dioxide. The amount of organic carbon deposited in the Bengal basin represents about 10 to 20 per cent of the total terrestrial organic carbon buried in oceanic sediments. High erosion rates in the Himalayas generate high sedimentation rates and low oxygen availability in the Bay of Bengal that sustain the observed extreme organic carbon burial efficiency. Active orogenic systems generate enhanced physical erosion and the resulting organic carbon burial buffers atmospheric carbon dioxide levels, thereby exerting a negative feedback on climate over geological timescales.