LLukas22/scidocs huggingface dataset:
The association between health literacy and outcomes of care among epilepsy patients

PURPOSE
To determine the association between health literacy and outcomes of care (seizure control and quality of life) in individuals with epilepsy followed at a level four epilepsy center.


METHODS
We conducted a face-to-face interview of patients seen at the Comprehensive Epilepsy Program of the University of Florida HSC/Jacksonville. We obtained demographic and clinical data, administered the Quality of Life in Epilepsy-10 inventory, and performed the Liverpool Seizure Severity Scale. We asked three screening questions taken from the Short Test of Functional Literacy in Adults. Using each health literacy question as the target variable we determined the predictor variables that were associated with responses to these questions and performed multiple linear regression to determine those that retained their significance.


RESULTS
One hundred and forty adult patients with epilepsy comprised the study population. On univariate analysis, patients who did poorly on questions for health literacy that included "difficulty reading hospital materials" and "difficulty filling out medical forms" had lower scores on the QOLIE-10 and lower annual household incomes. This significance was maintained on multivariate analysis. Those who had problems learning about their medical condition due to difficulties understanding written information had poorer scores on the QOLIE-10, increased seizure frequency, and lower educational levels on univariate analysis. However, on multivariate analysis, only poorer scores on quality of life were independently significant.


CONCLUSION
Patients with epilepsy who have limited health literacy do not necessarily have poorer seizure control but have lower quality of life scores.
Software Components Adaptive Integration

The key to integration is determining the relationship between what components are potentially reusable and how they can be properly adapted. This paper addresses how the results of specifcation matching can be used to guide the selection and application of adaptation tactics and airtonlate component adaptation and system integration based on type, interfnce, and behavior adaptation.
Molecular insights into androgen actions in male and female reproductive function from androgen receptor knockout models.

BACKGROUND
Androgens and the androgen receptor (AR) have well known roles in male reproduction, and recent genetic mouse models inactivating the Ar gene have conclusively defined a role for androgens in female reproduction. In males, AR gene inactivation severely disrupts spermatogenesis by interrupting completion of meiosis, thereby eliminating production of mature sperm leading to male sterility. These effects have overshadowed the study of additional post-meiotic androgen effects required for the production of fully functional spermatozoa, as well as the production of females with complete androgen insensitivity which cannot be produced by natural breeding. However, these limitations have been overcome by the creation of global and cell-specific AR knockout (ARKO) mouse models using Cre-LoxP genetic engineering.


METHODS
Pubmed searches were carried out using the following search terms: androgen receptor, knockout mouse and fertility. Articles published before the end of November 2009 were included.


RESULTS
These experimental models have identified cell-specific AR-mediated androgen actions in testis and androgen actions in sex accessory glands independent of testicular effects which are crucial for sperm maturation, motion and fertilizing ability. The ability to produce homozygous ARKO females has revealed that AR-mediated androgen actions are important for normal female fertility. AR function is required for full functionality in follicle health, development and ovulation through both intra-ovarian and neuroendocrine mechanisms.


CONCLUSIONS
ARKO mouse models provide valuable tools to unravel novel roles of AR-mediated actions in male and female reproductive function, and new insights into the role of androgens in human reproductive function.
Increased 30-day and 1-year mortality rates and lower coronary revascularisation rates following acute myocardial infarction in patients with autoimmune rheumatic disease

INTRODUCTION
It is now well-recognised that patients with autoimmune rheumatic disease (AIRD) have a predisposition to cardiovascular disease that results in increased morbidity and mortality. Following myocardial infarction (MI), patients with rheumatoid arthritis have been shown to have an increased case fatality rate; however, this has not been demonstrated in other forms of AIRD. The aim of this study was to compare case fatality rates following a first MI in patients with AIRD versus the general population. The secondary aim was to compare revascularisation treatment following MI in patients with AIRD versus the general population.


METHODS
A retrospective cohort study using two population-based linked databases was undertaken. Cases of first MI from July 2001 to June 2007 were identified based on International Statistical Classification of Diseases and Related Health Problems, Tenth Revision, Australian Modification, codes. Thirty-day and one-year mortality rates were calculated (all-cause and cardiovascular causes of death). Logistic regression models were fitted to calculate the odds of mortality by AIRD status with adjustment for relevant characteristics.


RESULTS
There were 79,390 individuals with a first MI, of whom 1,409 (1.8%) had AIRD. After adjusting for relevant covariates, the odds ratio (OR) for 30-day cardiovascular mortality in patients with AIRD was 1.44 (95% confidence interval (CI): 1.25 to 1.66), and the OR for 12-month cardiovascular mortality was 1.71 (95% CI: 1.51 to 1.94). The 90-day adjusted odds of percutaneous transluminal coronary angioplasty and coronary artery bypass graft were significantly lower in the AIRD group compared with controls (OR: 0.81, 95% CI: 0.70 to 0.94, and OR: 0.52, 95% CI: 0.39 to 0.69, respectively).


CONCLUSIONS
We identified a higher risk-adjusted mortality rate for the majority of patients with AIRD at 30 days and 12 months after first MI. We also identified lower post-MI revascularisation rates in the AIRD group, suggesting there may be current gaps in cardiovascular treatment for patients with AIRD.
Immunogenicity and safety of a booster dose of an investigational adjuvanted polyprotein HIV-1 vaccine in healthy adults and effect of administration of chloroquine.

This phase II study evaluated the effect of chloroquine on the specific CD8(+) T-cell responses to and the safety of a booster dose of investigational human immunodeficiency virus type 1 (HIV-1) F4/AS01(B) vaccine containing 10 μg of recombinant fusion protein (F4) adjuvanted with the AS01(B) adjuvant system. Healthy adults aged 21 to 41 years, primed 3 years before with two F4/AS01(B) doses containing 10 or 30 μg of F4 (ClinicalTrials.gov registration number NCT00434512), were randomized (1:1) to receive the F4/AS01(B) booster administered alone or 2 days after chloroquine (300 mg). F4-specific CD8(+)/CD4(+) T-cell responses were characterized by intracellular cytokine staining and lymphoproliferation assays and anti-F4 antibodies by enzyme-linked immunosorbent assays (ELISAs). No effect of chloroquine on CD4(+)/CD8(+) T-cell and antibody responses and no vaccine effect on CD8(+) T-cell responses (cytokine secretion or proliferation) were detected following F4/AS01(B) booster administration. In vitro, chloroquine had a direct inhibitory effect on AS01(B) adjuvant properties; AS01-induced cytokine production decreased upon coincubation of cells with chloroquine. In the pooled group of participants primed with F4/AS01(B) containing 10 μg of F4, CD4(+) T-cell and antibody responses induced by primary vaccination persisted for at least 3 years. The F4/AS01(B) booster induced strong F4-specific CD4(+) T-cell responses, which persisted for at least 6 months with similar frequencies and polyfunctional phenotypes as following primary vaccination, and high anti-F4 antibody concentrations, reaching higher levels than those following primary vaccination. The F4/AS01(B) booster had a clinically acceptable safety and reactogenicity profile. An F4/AS01(B) booster dose, administered alone or after chloroquine, induced robust antibody and F4-specific CD4(+) T-cell responses but no significant CD8(+) T-cell responses (cytokine secretion or proliferation) in healthy adults. (This study has been registered at ClinicalTrials.gov under registration number NCT00972725).
Fundamentals of timing information for test: How simple can we get?

Testing for small delay defects requires ATPG-FS tools to understand timing information of the design such that transition delay faults can be detected along longer paths. In this paper, timing information is analyzed for use in test automation tools to test for small delay defects. Fundamentals of static timing analysis are analyzed with regard to test. This paper concludes that Signal Integrity information can be ignored by test automation tools when timing information is used to guide ATPG tools towards longer paths. This paper also shows that a lack of understanding of clock trees in the long path ATPG algorithm leads to incorrect results.
Older type 2 diabetic patients are more likely to achieve glycaemic and cardiovascular risk factors targets than younger patients: analysis of a primary care database

BACKGROUND
Older subjects with type 2 diabetes mellitus (T2DM) have differential characteristics compared with middle-aged or younger populations, and require tailored management of the disease.


AIMS
To evaluate how clinical characteristics, degree of control of glycaemia and cardiovascular risk factors, presence of chronic complications and treatments differ between older T2DM patients and younger adults.


METHODS
Cross-sectional study using data from a population-based electronic database. We retrieved data from 318,020 patients ≥ 30 years diagnosed with T2DM, attended during 2011 in primary care centres in Catalonia, Spain. We performed descriptive and comparative analyses stratified by gender and age subgroups: ≤ 65, 66-75, 76-85 and >85 years.


RESULTS
Both men and women across older age subgroups (> 65 years) had longer diabetes duration than younger adults (8.0 vs. 5.6 in men and 8.4 vs. 6.9 years in women; p < 0.001), but better glycaemic control (mean glycated haemoglobin 7.1 vs. 7.7 in men and 7.1 vs. 7.4 in women; p < 0.001), and better combined control of different cardiovascular risk factors (p < 0.001). Moreover, older patients were more likely to achieve glycaemic targets irrespective of having cardiovascular disease. The use of oral antidiabetics decreased with increasing age, and insulin in monotherapy was more frequently prescribed among patients in the older age subgroups. Diabetes-related complications were more frequent in men of all group ages. In the older age subgroups, patients of both sexes had a longer duration of T2DM but better glycaemic control. In this context, the prevalence of diabetic retinopathy decreased unexpectedly with increasing age.


CONCLUSION
Control of glycaemia and cardiovascular risk factors was better among older T2DM patients. There is a need for prospective studies to quantify the weight of risk factors in each complication to adapt the therapeutic and care approaches in elderly people.
Educating the citizens: Visions of China in late Qing history textbooks

In recent years, the late Qing invention of national history has received considerable attention. Taking a “history of ideas” approach, scholars such as Prasenjit Duara, Rebecca Karl, Xiaobing Tang, Edward Wang, and Ying-shih Yu discuss how late Qing historians adopted foreign concepts such as the nation-state, linear progress, and scientific rationality. This chapter examines the late Qing historical discourse from the perspective of the social and political changes at the turn of the 20th century. Focusing on history textbooks, the author's premise is that the late Qing historical discourse emerged in a critical moment when the Qing government was building a national school system to replace the civil service examinations. Described by Ping-ti Ho as “the ladder of success” for the literati, the civil service examination system had been the main vehicle of social mobility for the educated elite for centuries. Keywords: civil service examination; foreign concepts; historical discourse; history textbooks; late Qing; national history; national school system; Qing government
Simulation of SPWM Control Method for UPS System

This paper deals with the analysis of implementing Sinusoidal Pulse Width Modulation (SPWM) controlling strategy in three phase Uninterruptible Power Supply (UPS) system operating under highly nonlinear load. The conventional type of controller is not enough to reduce harmonics in the system under highly nonlinear load in high power system. The SPWM based method is applied to the UPS system to reduce THD level at minimum value. The Simulation is done by Matlab/Simulink environment.
Karl Valentin's 'Father and Son Discuss the War'

AbstractThe authors have collaborated for a number of years on researching the cabaret career of Karl Valentin. Here they provide a brief summary of Valentin's active life as a preface to their translation of one of his last cabaret sketches.
Wearable Sensors in Healthcare and Sensor-Enhanced Health Information Systems: All Our Tomorrows?

Wearable sensor systems which allow for remote or self-monitoring of health-related parameters are regarded as one means to alleviate the consequences of demographic change. This paper aims to summarize current research in wearable sensors as well as in sensor-enhanced health information systems. Wearable sensor technologies are already advanced in terms of their technical capabilities and are frequently used for cardio-vascular monitoring. Epidemiologic predictions suggest that neuropsychiatric diseases will have a growing impact on our health systems and thus should be addressed more intensively. Two current project examples demonstrate the benefit of wearable sensor technologies: long-term, objective measurement under daily-life, unsupervised conditions. Finally, up-to-date approaches for the implementation of sensor-enhanced health information systems are outlined. Wearable sensors are an integral part of future pervasive, ubiquitous and person-centered health care delivery. Future challenges include their integration into sensor-enhanced health information systems and sound evaluation studies involving measures of workload reduction and costs.
Needle echogenicity in sonographically guided regional anesthesia: blinded comparison of 4 enhanced needles and validation of visual criteria for evaluation.

OBJECTIVES
Needle visualization is important for sonographically guided regional anesthesia procedures. Needle characteristics that improve needle visualization are therefore important to anesthesiologists. This study compared several echogenic needle designs by defining characteristics of needle echogenicity and assessing regional anesthesiologist preferences for these characteristics across various needle angles.


METHODS
Twelve blinded regional anesthesiologists graded 5 randomized block needles (1 nonechogenic control and 4 echogenic) on 4 predefined characteristics (overall brightness of the needle, overall clarity of the needle, brightness of the needle tip, and clarity of the needle tip). In-plane needle images in a gel phantom were obtained at 4 needle angles (15°, 30°, 45°, and 60°). Participants rated specific needle characteristics for each needle at each angle and then ranked their overall needle preferences.


RESULTS
Significant differences in all 4 needle characteristics were found across needle types (P< .01). Clarity of the needle tip was significantly associated with overall needle rank (P = .009). Other needle visualization characteristics were not significantly correlated with needle rank. The SonoPlex Stim needle (Pajunk Medical Systems, Tucker, GA) was rated highest in all 4 predefined needle characteristics as well as overall needle rank.


CONCLUSIONS
This study shows that anesthesiologists prefer certain visual characteristics of needles used in sonographically guided regional anesthesia procedures. Specifically, needle tip clarity most closely predicted clinician needle preferences. These results support the idea that all echogenic needle designs do not uniformly enhance needle visualization. Further studies are needed to determine whether needles with superior tip clarity predict not only clinician preferences but also improved sonographically guided regional anesthetic outcomes.
Institutionalizing enterprise resource planning in the Saudi steel industry: A punctuated socio-technical analysis

In this article, we analyze institutionalization as a process of transferring and stabilizing material artifacts and routines in the form of enterprise resource planning (ERP) systems. Although past studies have analyzed institutionalization as structuring around scripts or discourse moves, we emphasize the material role of artifacts and routines as carriers of institutional logics. In addition, insitutionalization is not linear and incremental, but goes through sudden, nonlinear disruptions. To this end, we apply punctuated socio-technical information system change (PSIC) model that draws upon Gersick’s model of change to identify and trace moves that are critical during the institutionalization. The model accounts for ERP institutionalization by chronicling complex interactions between socio-technical elements in the implementation system, the work system, and organizational and environmental context which together account for the institutionalization outcome. We use the model to analyze a longitudinal case covering 11 years (1993–2004) of ERP implementation processes in a large Saudi steel firm. Our analysis shows that the proposed material and punctuated lens toward institutionalization offers rich insights how and why ERP systems become institutions and why their institutionalization is difficult and unfolds in unpredictable ways. We conclude that the normally held assumptions of successful linear and incremental adaptation to new institutional patterns logics out by ERP systems do not hold. Journal of Information Technology (2009) 24, 286–304. doi:10.1057/jit.2009.14
Solution of the system of ordinary differential equations by Adomian decomposition method

In this article we use Adomian decomposition method, which is a well-known method for solving functional equations now-a-days, to solve systems of differential equations of the first order and an ordinary differential equation of any order by converting it into a system of differential of the order one. Theoretical considerations are being discussed, and convergence of the method for theses systems is addressed. Some examples are presented to show the ability of the method for linear and non-linear systems of differential equations. 2002 Elsevier Inc. All rights reserved.
A Novel Feature-based Approach to Chinese Entity Relation Extraction

Relation extraction is the task of finding semantic relations between two entities from text. In this paper, we propose a novel feature-based Chinese relation extraction approach that explicitly defines and explores nine positional structures between two entities. We also suggest some correction and inference mechanisms based on relation hierarchy and co-reference information etc. The approach is effective when evaluated on the ACE 2005 Chinese data set.
Randomized comparison of final kissing balloon dilatation versus no final kissing balloon dilatation in patients with coronary bifurcation lesions treated with main vessel stenting: the Nordic-Baltic Bifurcation Study III.

BACKGROUND
It is unknown whether the preferred 1-stent bifurcation stenting approach with stenting of the main vessel (MV) and optional side branch stenting using drug-eluting stents should be finalized by a kissing balloon dilatation (FKBD). Therefore, we compared strategies of MV stenting with and without FKBD.


METHODS AND RESULTS
We randomized 477 patients with a bifurcation lesion to FKBD (n=238) or no FKBD (n=239) after MV stenting. The primary end point was major adverse cardiac events: cardiac death, non-procedure-related index lesion myocardial infarction, target lesion revascularization, or stent thrombosis within 6 months. The 6-month major adverse cardiac event rates were 2.1% and 2.5% (P=1.00) in the FKBD and no-FKBD groups, respectively. Procedure and fluoroscopy times were longer and more contrast media was needed in the FKBD group than in the no-FKBD group. Three hundred twenty-six patients had a quantitative coronary assessment. At 8 months, the rate of binary (re)stenosis in the entire bifurcation lesion (MV and side branch) was 11.0% versus 17.3% (P=0.11), in the MV was 3.1% versus 2.5% (P=0.68), and in the side branch was 7.9% versus 15.4% (P=0.039) in the FKBD versus no-FKBD groups, respectively. In patients with true bifurcation lesions, the side branch restenosis rate was 7.6% versus 20.0% (P=0.024) in the FKBD and no-FKBD groups, respectively.


CONCLUSIONS
MV stenting strategies with and without FKBD were associated with similar clinical outcomes. FKBD reduced angiographic side branch (re)stenosis, especially in patients with true bifurcation lesions. The simple no-FKBD procedures resulted in reduced use of contrast media and shorter procedure and fluoroscopy times. Long-term data on stent thrombosis are needed. Clinical Trial Registration- URL: http://clinicaltrials.gov. Unique identifier: NCT00914199.
Insulin growth factor 2 (IGF2) as an emergent target in psychiatric and neurological disorders. Review

Insulin-like growth factor 2 (IGF2) is abundantly expressed in the central nervous system (CNS). Recent evidence highlights the role of IGF2 in the brain, sustained by data showing its alterations as a common feature across a variety of psychiatric and neurological disorders. Previous studies emphasize the potential role of IGF2 in psychiatric and neurological conditions as well as in memory impairments, targeting IGF2 as a pro-cognitive agent. New research on animal models supports that upcoming investigations should explore IGF2's strong promising role as a memory enhancer. The lack of effective treatments for cognitive disturbances as a result of psychiatric diseases lead to further explore IGF2 as a promising target for the development of new pharmacology for the treatment of memory dysfunctions. In this review, we aim at gathering all recent relevant studies and findings on the role of IGF2 in the development of psychiatric diseases that occur with cognitive problems.
Action principle for the classical dual electrodynamics

Abstract The purpose of this paper is to formulate an action principle which allows for the construction of a classical lagrangian including both electric and magnetic currents. The lagrangian is non-local and shown to yield all the expected (local) equations for dual electrodynamics.