LLukas22/scidocs huggingface dataset:
Antecedents and consequences of organizational innovation and organizational learning in entrepreneurship

Purpose – To analyze a series of strategic capabilities/factors that affects organizational innovation (OI) and organizational learning (OL) (personal mastery, transformational leadership, shared vision, proactivity and environment) and demonstrate that OL and innovation are positively related to organizational performance. Design/methodology/approach – Based on prior research, the paper develops a number of testable hypotheses. It examines how personal mastery, transformational leadership, shared vision, proactivity and environment influence improvements in performance. The paper uses inter-factor correlations matrix and multiple regressions analyses and empirically tests these hypotheses using a sample of 408 Spanish organizations. Findings – Considers OI and OL jointly to promote organizational entrepreneurship and to increase competitive advantages. Empirically reflects the need to strengthen different strategic capabilities to achieve an adequate level of both organizational issues and thus improve performance and encourage entrepreneurship. Research limitations/implications – Survey data based on self-reports may be subject to social desirability bias. The external validation of some of the variables from the archival data of a subset of respondents increased confidence in self-reports and reduced the risk of common method variance. The paper needs to concentrate on other sectors. Future studies should place greater emphasis on longitudinal studies and should be based on a larger sample, preferably in more than one country. It would be interesting to analyze other strategic activities for entrepreneurship. Practical implications – Organizations’ managers must encourage the organization’s members to achieve high levels of personal mastery. This environment can be provided by continually encouraging personal vision. The style of management must be more transformational. They must foster shared vision. The leader must prepare the organization and shape the mental models. Specific actions must be taken to overcome the internal and external obstacles to shared vision. The leader will play an important role in linking the organization and the environment and generate proactivity. Originality/value – This paper is fundamental to promote strategy capabilities that are necessary to entrepreneurship (OL and OI).
Quality-oriented software architecture development

Producing software products of good quality requires that quality requirements are taken into account as early as possible. In theory, the first place in which quality requirements can be addressed is architectural models of software. However, in practice, the softwares architecture is only used to describe the functionality of the developed software. This means that the implemented software may not fulfil its quality requirements and some parts of the implementation process might be useless. The main research problem in this work is how to define and connect quality requirements with the software architecture in such a way that the requirements can vary between software components and software family members. An environment for defining and collecting softwares quality requirements was designed and implemented in this work. The environment consists of three main parts: quality meta-data management, quality modelling and quality evaluation. The quality meta-data management provides a possibility to define each quality attribute into an ontology form. These ontologies are utilized when quality requirements are defined in order to define the requirements in a uniform way in the quality modelling phase. Quality requirements are defined according to the UML profile developed for that purpose, so that it would be possible to represent these requirements in the architectural models. Finally, the architectures quality is evaluated using evaluation tools. The purpose was to implement the whole environment on the Eclipse platform using available open source components. The Eclipse was selected because it is a widely used open source platform, which makes it easier to distribute the software developed during this work. The Eclipse tool evaluation confirmed that TOPCASED is the best available UML tool for the Eclipse and the best Eclipse ontology tool is EODM. However, EODM does not fulfil all the desired requirements of this work and this enforced the use of the Protégé ontology tool.
Which patients benefit most from adjuvant aromatase inhibitors? Results using a composite measure of prognostic risk in the BIG 1-98 randomized trial.

BACKGROUND
On average, aromatase inhibitors are better than tamoxifen when used as initial or sequential therapy for postmenopausal women with endocrine-responsive early breast cancer. Because there may be contraindications to their use based on side-effects or cost, we investigated subgroups in which aromatase inhibitors may be more or less important.


PATIENTS AND METHODS
Breast International Group 1-98 trial randomized 6182 women among four groups comparing letrozole and tamoxifen with sequences of each agent; 5177 (84%) had centrally confirmed estrogen receptor (ER) positivity. We assessed whether centrally determined ER, progesterone receptor (PgR), human epidermal growth factor receptor 2, and Ki-67 labeling index, alone or in combination with other prognostic features, predicted the magnitude of letrozole effectiveness compared with either sequence or tamoxifen monotherapy.


RESULTS
Individually, none of the markers significantly predicted differential treatment effects. Subpopulation treatment effect pattern plot analysis of a composite measure of prognostic risk revealed three patterns. Estimated 5-year disease-free survival for letrozole monotherapy, letrozole→tamoxifen, tamoxifen→letrozole, and tamoxifen monotherapy were 96%, 94%, 93%, and 94%, respectively, for patients at lowest risk; 90%, 91%, 93%, and 86%, respectively, for patients at intermediate risk; and 80%, 76%, 74%, and 69%, respectively, for patients at highest risk.


CONCLUSION
A composite measure of risk informs treatment selection better than individual biomarkers and supports the choice of 5 years of letrozole for patients at highest risk for recurrence.
Effect of bronchoalveolar lavage-directed therapy on Pseudomonas aeruginosa infection and structural lung injury in children with cystic fibrosis: a randomized trial.

CONTEXT
Early pulmonary infection in children with cystic fibrosis leads to increased morbidity and mortality. Despite wide use of oropharyngeal cultures to identify pulmonary infection, concerns remain over their diagnostic accuracy. While bronchoalveolar lavage (BAL) is an alternative diagnostic tool, evidence for its clinical benefit is lacking.


OBJECTIVE
To determine if BAL-directed therapy for pulmonary exacerbations during the first 5 years of life provides better outcomes than current standard practice relying on clinical features and oropharyngeal cultures.


DESIGN, SETTING, AND PARTICIPANTS
The Australasian Cystic Fibrosis Bronchoalveolar Lavage (ACFBAL) randomized controlled trial, recruiting infants diagnosed with cystic fibrosis through newborn screening programs in 8 Australasian cystic fibrosis centers. Recruitment occurred between June 1, 1999, and April 30, 2005, with the study ending on December 31, 2009.


INTERVENTIONS
BAL-directed (n = 84) or standard (n = 86) therapy until age 5 years. The BAL-directed therapy group underwent BAL before age 6 months when well, when hospitalized for pulmonary exacerbations, if Pseudomonas aeruginosa was detected in oropharyngeal specimens, and after P. aeruginosa eradication therapy. Treatment was prescribed according to BAL or oropharyngeal culture results.


MAIN OUTCOME MEASURES
Primary outcomes at age 5 years were prevalence of P. aeruginosa on BAL cultures and total cystic fibrosis computed tomography (CF-CT) score (as a percentage of the maximum score) on high-resolution chest CT scan.


RESULTS
Of 267 infants diagnosed with cystic fibrosis following newborn screening, 170 were enrolled and randomized, and 157 completed the study. At age 5 years, 8 of 79 children (10%) in the BAL-directed therapy group and 9 of 76 (12%) in the standard therapy group had P. aeruginosa in final BAL cultures (risk difference, -1.7% [95% confidence interval, -11.6% to 8.1%]; P = .73). Mean total CF-CT scores for the BAL-directed therapy and standard therapy groups were 3.0% and 2.8%, respectively (mean difference, 0.19% [95% confidence interval, -0.94% to 1.33%]; P = .74).


CONCLUSION
Among infants diagnosed with cystic fibrosis, BAL-directed therapy did not result in a lower prevalence of P. aeruginosa infection or lower total CF-CT score when compared with standard therapy at age 5 years.


TRIAL REGISTRATION
anzctr.org.au Identifier: ACTRN12605000665639.
On negative results when using sentiment analysis tools for software engineering research

Recent years have seen an increasing attention to social aspects of software engineering, including studies of emotions and sentiments experienced and expressed by the software developers. Most of these studies reuse existing sentiment analysis tools such as SentiStrength and NLTK. However, these tools have been trained on product reviews and movie reviews and, therefore, their results might not be applicable in the software engineering domain. In this paper we study whether the sentiment analysis tools agree with the sentiment recognized by human evaluators (as reported in an earlier study) as well as with each other. Furthermore, we evaluate the impact of the choice of a sentiment analysis tool on software engineering studies by conducting a simple study of differences in issue resolution times for positive, negative and neutral texts. We repeat the study for seven datasets (issue trackers and Stack Overflow questions) and different sentiment analysis tools and observe that the disagreement between the tools can lead to diverging conclusions. Finally, we perform two replications of previously published studies and observe that the results of those studies cannot be confirmed when a different sentiment analysis tool is used.
Comparison between Conventional and Fuzzy Logic PID Controllers for Controlling DC Motors

Fuzzy logic and proportional-integral-derivative (PID) controllers are compared for use in direct current (DC) motors positioning system. A simulation study of the PID position controller for the armature-controlled with fixed field and fieldcontrolled with fixed armature current DC motors is performed. Fuzzy rules and the inferencing mechanism of the fuzzy logic controller (FLC) are evaluated by using conventional rule-lookup tables that encode the control knowledge in a rules form. The performance assessment of the studied position controllers is based on transient response and error integral criteria. The results obtained from the FLC are not only superior in the rise time, speed fluctuations, and percent overshoot but also much better in the controller output signal structure, which is much remarkable in terms of the hardware implementation.
An unconventional role of ligand in continuously tuning of metal-metal interfacial strain.

We show that embedding of a surface ligand can dramatically affect the metal-metal interfacial energy, making it possible to create nanostructures in defiance of traditional wisdom. Despite matching Au-Ag lattices, Au-Ag hybrid NPs can be continuously tuned from concentric core-shell, eccentric core-shell, acorn, to dimer structures. This method can be extended to tune even Au-Au and Ag-Ag interfaces.
Sophia Observation withdrawal Symptoms-Paediatric Delirium scale: A tool for early screening of delirium in the PICU.

BACKGROUND
Delirium in critically ill children is a severe neuropsychiatric disorder which has gained increased attention from clinicians. Early identification of delirium is essential for successful management. The Sophia Observation withdrawal Symptoms-Paediatric Delirium (SOS-PD) scale was developed to detect Paediatric Delirium (PD) at an early stage.


OBJECTIVE
The aim of this study was to determine the measurement properties of the PD component of the SOS-PD scale in critically ill children.


METHODS
A prospective, observational study was performed in patients aged 3 months or older and admitted for more than 48h. These patients were assessed with the SOS-PD scale three times a day. If the SOS-PD total score was 4 or higher in two consecutive observations, the child psychiatrist was consulted to assess the diagnosis of PD using the Diagnostic and Statistical Manual-IV criteria as the "gold standard". The child psychiatrist was blinded to outcomes of the SOS-PD. The interrater reliability of the SOS-PD between the care-giving nurse and a researcher was calculated with the intraclass correlation coefficient (ICC).


RESULTS
A total of 2088 assessments were performed in 146 children (median age 49 months; IQR 13-140). The ICC of 16 paired nurse-researcher observations was 0.90 (95% CI 0.70-0.96). We compared 63 diagnoses of the child psychiatrist versus SOS-PD assessments in 14 patients, in 13 of whom the diagnosis of PD was confirmed. The sensitivity was 96.8% (95% CI 80.4-99.5%) and the specificity was 92.0% (95% CI 59.7-98.9%).


CONCLUSIONS
The SOS-PD scale shows promising validity for early screening of PD. Further evidence should be obtained from an international multicentre study.
Eye-Tracking Users' Behavior in Relation to Cognitive Style within an E-learning Environment

Eye-tracking measurements may be used as a method of identifying users’ actual behavior in a hypermedia setting. In this research, an eye-tracking experiment was conducted in order to validate the construct of cognitive style as a personalization parameter in adaptive e-Learning systems. The main research question was whether the verbalizer/ imager axis of the Cognitive Style Analysis theory reflects actual preferences in an e-learning environment and properly identifies learner types. The findings from a sample of 21 participants reveal statistically significant differences among types of learners; as hypothesized, imagers concentrate on visual content, verbalizers on text, while intermediates are placed in between.
Mother-to-child transmission of HIV-1: association with malaria prevention, anaemia and placental malaria.

OBJECTIVES
Malaria infection may impact on mother-to-child transmission (MTCT) of HIV-1. Prevention of malaria in pregnancy could thus potentially affect MTCT of HIV. We studied the impact of intermittent preventive treatment during pregnancy (IPTp) on HIV-1 MTCT in southern Mozambique.


METHODS
A total of 207 HIV-positive Mozambican pregnant women were enrolled in the study as part of a randomized placebo-controlled trial of two-dose sulfadoxine-pyrimethamine (SP) IPTp in women receiving single-dose nevirapine to prevent MTCT of HIV. HIV RNA viral load, maternal anaemia and peripheral and placental malaria were assessed at delivery. Infant HIV status was determined by DNA polymerase chain reaction (PCR) at 1 month of age.


RESULTS
There were 19 transmissions of HIV in 153 mother-infant pairs. IPTp with SP did not have a significant impact on MTCT (11.8% in the SP group vs. 13.2% in the placebo group; P=0.784) or on maternal HIV RNA viral load [16 312 (interquartile range {IQR} 4076-69 296) HIV-1 RNA copies/mL in the SP group vs. 18 274 (IQR 5471-74 104) copies/mL in the placebo group; P=0.715]. In multivariate analysis, maternal HIV RNA viral load [adjusted odds ratio (AOR) 19.9; 95% confidence interval (CI) 2.3-172; P=0.006] and anaemia (haematocrit <33%; AOR 7.5; 95% CI 1.7-32.4; P=0.007) were independent risk factors for MTCT. Placental malaria was associated with a decrease in MTCT (AOR 0.23; 95% CI 0.06-0.89; P=0.034).


CONCLUSIONS
IPTp with SP was not associated with a significant impact on MTCT of HIV. Maternal anaemia was an independent risk factor for MTCT.
Physical fitness and plasma leptin in women with recent gestational diabetes

AIMS/HYPOTHESIS
Low physical fitness (PF) is a risk factor for type 2 diabetes mellitus (T2D). Women with a history of gestational diabetes (GDM) are at risk for T2D at a young age, but the role of PF in this population is not clear. PF has also been found to correlate inversely with plasma leptin in previous studies. Here, we examine whether women who had GDM have lower PF than women after a normoglycemic pregnancy and, second, whether PF is associated with plasma leptin, independently of body fat mass.


METHODS
Cross-sectional analysis of 236 participants in the PPSDiab Study (cohort study of women 3-16 months after delivery, 152 after gestational diabetes (pGDM), 84 after normoglycemic pregnancy (control subjects); consecutively recruited 2011-16); medical history, physical examination with bioelectrical impedance analysis (BIA), whole body magnetic resonance imaging (MRI) (n = 154), 5-point oral glucose tolerance test, cardiopulmonary exercise testing, clinical chemistry including fasting plasma leptin; statistical analysis with Mann-Whitney U and t -test, Spearman correlation coefficient, multiple linear regression.


RESULTS
Women pGDM had lower maximally achieved oxygen uptake (VO2peak/kg: 25.7(21.3-29.9) vs. 30.0(26.6-34.1)ml/min/kg; total VO2peak: 1733(1552-2005) vs. 1970(1767-2238)ml/min; p<0.0001 for both), and maximum workload (122.5(105.5-136.5) vs. 141.0(128.5-159.5)W; p<0.0001). Fasting plasma leptin correlated inversely with PF (VO2peak/kg ρ = -0.72 p<0.0001; VO2peak ρ = -0.16 p = 0.015; max. load ρ = -0.35 p<0.0001). These associations remained significant with adjustment for body mass index, or for body fat mass (BIA and MRI).


CONCLUSIONS/INTERPRETATION
Women with a recent history of GDM were less fit than control subjects. Low PF may therefore contribute to the risk for T2D after GDM. This should be tested in intervention studies. Low PF also associated with increased leptin levels-independently of body fat. PF may therefore influence leptin levels and signaling. This hypothesis requires further investigation.
Study of Mental Activity and Regular Training (SMART) in at risk individuals: A randomised double blind, sham controlled, longitudinal trial

BACKGROUND
The extent to which mental and physical exercise may slow cognitive decline in adults with early signs of cognitive impairment is unknown. This article provides the rationale and methodology of the first trial to investigate the isolated and combined effects of cognitive training (CT) and progressive resistance training (PRT) on general cognitive function and functional independence in older adults with early cognitive impairment: Study of Mental and Regular Training (SMART). Our secondary aim is to quantify the differential adaptations to these interventions in terms of brain morphology and function, cardiovascular and metabolic function, exercise capacity, psychological state and body composition, to identify the potential mechanisms of benefit and broader health status effects.


METHODS
SMART is a double-blind randomized, double sham-controlled trial. One hundred and thirty-two community-dwelling volunteers will be recruited. Primary inclusion criteria are: at risk for cognitive decline as defined by neuropsychology assessment, low physical activity levels, stable disease, and age over 55 years. The two active interventions are computerized CT and whole body, high intensity PRT. The two sham interventions are educational videos and seated calisthenics. Participants are randomized into 1 of 4 supervised training groups (2 d/wk×6 mo) in a fully factorial design. Primary outcomes measured at baseline, 6, and 18 months are the Alzheimer's Disease Assessment Scale (ADAS-Cog), neuropsychological test scores, and Bayer Informant Instrumental Activities of Daily Living (B-IADLs). Secondary outcomes are psychological well-being, quality of life, cardiovascular and musculoskeletal function, body composition, insulin resistance, systemic inflammation and anabolic/neurotrophic hormones, and brain morphology and function via Magnetic Resonance Imaging (MRI) and Spectroscopy (fMRS).


DISCUSSION
SMART will provide a novel evaluation of the immediate and long term benefits of CT, PRT, and combined CT and PRT on global cognitive function and brain morphology, as well as potential underlying mechanisms of adaptation in older adults at risk of further cognitive decline.


TRIAL REGISTRATION
Australia and New Zealand Clinical Trials Register (ANZCTR): ANZCTRN12608000489392.
Bayesian stochastic frontier analysis using WinBUGS

Markov chain Monte Carlo (MCMC) methods have become a ubiquitous tool in Bayesian analysis. This paper implements MCMC methods for Bayesian analysis of stochastic frontier models using the WinBUGS package, a freely available software. General code for cross-sectional and panel data are presented and various ways of summarizing posterior inference are discussed. Several examples illustrate that analyses with models of genuine practical interest can be performed straightforwardly and model changes are easily implemented. Although WinBUGS may not be that efficient for more complicated models, it does make Bayesian inference with stochastic frontier models easily accessible for applied researchers and its generic structure allows for a lot of flexibility in model specification.
What Women and Men Should Be, Shouldn’t Be, Are Allowed to Be, and Don’t Have to Be: The Contents of Prescriptive Gender Stereotypes

This article presents a four-category framework to characterize the contents of prescriptive gender stereotypes. The framework distinguishes between prescriptions and proscriptions that are intensified by virtue of one’s gender, and those that are relaxed by virtue of one’s gender. Two studies examined the utility of this framework for characterizing prescriptive gender stereotypes in American society (Study 1) and in the highly masculine context of Princeton University (Study 2). The results demonstrated the persistence of traditional gender prescriptions in both contexts, but also revealed distinct areas of societal vigilance and leeway for each gender. In addition, they showed that women are seen more positively, relative to societal standards, than are men. We consider the implications of this framework for research on reactions to gender stereotype deviants and sex discrimination.
Effect of inhibition of cytochrome P450 enzymes 2D6 and 3A4 on the pharmacokinetics of intravenous oxycodone: a randomized, three-phase, crossover, placebo-controlled study.

BACKGROUND AND OBJECTIVE
Oxycodone is a μ-opioid receptor agonist that is mainly metabolized by hepatic cytochrome P450 (CYP) enzymes. Because CYP enzymes can be inhibited by other drugs, the pharmacokinetics of oxycodone are prone to drug interactions. The aim of this study was to determine whether inhibition of CYP2D6 alone by paroxetine or inhibition of both CYP2D6 and CYP3A4 by a combination of paroxetine and itraconazole alters the pharmacokinetics of and pharmacological response to intravenous oxycodone.


METHODS
We used a randomized, three-phase, crossover, placebo-controlled study design in 12 healthy subjects. The subjects were given 0.1  mg/kg of intravenous oxycodone after pre-treatments with placebo, paroxetine or a combination of paroxetine and itraconazole for 4 days. Plasma concentrations of oxycodone and its oxidative metabolites were measured over 48 hours, and pharmacokinetic and pharmacodynamic parameters subsequently evaluated.


RESULTS
The effect of paroxetine on the plasma concentrations of oxycodone was negligible. The combination of paroxetine and itraconazole prolonged the mean elimination half-life of oxycodone from 3.8 to 6.6 hours (p < 0.001), and increased the exposure to oxycodone 2-fold (p < 0.001). However, these changes were not reflected in pharmacological response.


CONCLUSION
The results of this study indicate that there are no clinically relevant drug interactions with intravenous oxycodone and inhibitors of CYP2D6. If both oxidative metabolic pathways via CYP3A4 and 2D6 are inhibited the exposure to intravenous oxycodone increases substantially.