LLukas22/scidocs huggingface dataset:
Planification d'expériences numériques en phase exploratoire pour la simulation des phénomènes complexes

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. Planification d’expériences numériques en phase exploratoire pour la simulation des phénomènes complexes Jessica Franco
Improving Safety in Medical Devices and Systems

We need to improve healthcare technologies - electronic patient records, medical devices - by reducing use error and, in particular, unnoticed errors, since unnoticed errors cannot be managed by clinicians to reduce patient harm. Every system we have examined has multiple opportunities for safer design, suggesting a safety scoring system. Making safety scores visible will enable all stakeholders (regulators, procurers, clinicians, incident investigators, journalists, and of course patients) to be more informed, and hence put pressure on manufacturers to improve design safety. In the longer run, safety scores will need to evolve, both to accommodate manufacturers improving device safety and to accommodate insights from further research in design-induced error.
Student modeling approaches: A literature review for the last decade

0957-4174/$ see front matter 2013 Elsevier Ltd. A http://dx.doi.org/10.1016/j.eswa.2013.02.007 ⇑ Corresponding author. Tel.: +3
Environment: Labs should cut plastic waste too

Many governments now impose charges for single-use plastic bags and bottles. As responsible researchers, we should cut back on disposable plastics (see also G. Bistulfi Nature 502, 170; 2013). We estimate that the 280 bench scientists in our bioscience department generated roughly 267 tonnes of plastic in 2014 (data from University of Exeter Sustainability and Waste and Resource Management offices). That is equivalent to about 5.7 million empty 2-litre plastic bottles. Some 20,500 institutions worldwide are involved in biological, medical or agricultural research (where plastic disposal is likely to be heaviest), so that could equate to around 5.5 million tonnes of lab plastic waste in 2014 — roughly the combined tonnage of 67 cruise liners, and equal to 83% of the plastic recycled worldwide in 2012. We justify our use of disposables on the grounds of costs and time saved. Grant agencies therefore need to introduce incentives to reduce plastic waste, for example by funding lab washing-up and recycling facilities, and possibly to make greener lab practices a requirement in the grant-application process. Bond villain fails neuroanatomy The thrills and action in Spectre, the latest James Bond film, were somewhat marred for this viewer by a fundamental neuroanatomical blunder. The scene is a Moroccan desert. Bond's nemesis is torturing our hero using a head clamp fused with a robotic drill. Intending to erase Bond's memory of faces, the villain says he is directing his drill to the (lateral) " fusiform gyrus " — correctly identifying a core brain area for facial recognition (J. Parvizi et al. But the film-makers got it wrong. Whereas the drill should have been aimed just in front of 007's ear, it was directed below the mastoid process under and behind his left ear. There it would have met the lateral part of the first or second cervical vertebra, perhaps hitting the ipsilateral vertebral artery and triggering a stroke or massive haemorrhage. Unless fatal, it certainly would not have deleted the bank of faces in Bond's memory. A successful systematics initiative in arachnology could provide an invaluable model for rapid delivery of taxonomic data for other animal groups. Until now, the inaccessibility of the classical and obscure taxonomic literature has been a major hindrance to the field's progress. The World Spider Catalog (www.wsc.nmbe.ch), launched last year, now contains complete taxonomic data for almost 46,000 validated spider species and an embedded collection of 13,000 references. Spiders are …
CO2 bio-mitigation using microalgae

Microalgae are a group of unicellular or simple multicellular photosynthetic microorganisms that can fix CO2 efficiently from different sources, including the atmosphere, industrial exhaust gases, and soluble carbonate salts. Combination of CO2 fixation, biofuel production, and wastewater treatment may provide a very promising alternative to current CO2 mitigation strategies.
Measuring plagiarism: Researching what students do, not what they say they do

Student plagiarism in colleges and universities has become a controversial issue in recent years. A key problem has been the lack of reliable empirical data on the frequency, nature and extent of plagiarism in student assignments. The aim of the study described here was to provide this data. Patterns of plagiarism were tracked in two university business assignments involving over 500 students and over 1000 scripts. Turnitin software was used to facilitate the identification of plagiarised material in assignments. The findings confirmed some common assertions about the nature of student plagiarism but did not provide support for a number of others.
Change detection from remotely sensed images : From pixel-based to object-based approaches

The appetite for up-to-date information about earth’s surface is ever increasing, as such information provides a base for a large number of applications, including local, regional and global resources monitoring, land-cover and land-use change monitoring, and environmental studies. The data from remote sensing satellites provide opportunities to acquire information about land at varying resolutions and has been widely used for change detection studies. A large number of change detection methodologies and techniques, utilizing remotely sensed data, have been developed, and newer techniques are still emerging. This paper begins with a discussion of the traditionally pixel-based and (mostly) statistics-oriented change detection techniques which focus mainly on the spectral values and mostly ignore the spatial context. This is succeeded by a review of object-based change detection techniques. Finally there is a brief discussion of spatial data mining techniques in image processing and change detection from remote sensing data. The merits and issues of different techniques are compared. The importance of the exponential increase in the image data volume and multiple sensors and associated challenges on the development of change detection techniques are highlighted. With the wide use of very-high-resolution (VHR) remotely sensed images, object-based methods and data mining techniques may have more potential in change detection. 2013 International Society for Photogrammetry and Remote Sensing, Inc. (ISPRS) Published by Elsevier B.V. All rights reserved.
Comparative Analysis of DES , AES , RSA Encryption Algorithms

As the increasing growth of the computing technology and network technology, it also increases data storage demands. Data Security has become a crucial issue in electronic communication. Secret writing has come up as a solution, and plays a vital role in data security system. It uses some algorithms to scramble data into unreadable text which might be only being decrypted by party those having the associated key. These algorithms consume a major amount of computing resources such as memory and battery power and computation time. This paper accomplishes comparative analysis of encryption standards DES, AES and RSA considering various parameters such as computation time, memory usages. A cryptographic tool is used for performing experiments. Experiments results are given to analyses the effectiveness of symmetric and asymmetric algorithms. Keywords— Encryption, secret key encryption, public key encryption, DES, AES, RSA encryption, Symmetric
Comparative efficacy and tolerability of antidepressants for major depressive disorder in children and adolescents: a network meta-analysis

BACKGROUND
Major depressive disorder is one of the most common mental disorders in children and adolescents. However, whether to use pharmacological interventions in this population and which drug should be preferred are still matters of controversy. Consequently, we aimed to compare and rank antidepressants and placebo for major depressive disorder in young people.


METHODS
We did a network meta-analysis to identify both direct and indirect evidence from relevant trials. We searched PubMed, the Cochrane Library, Web of Science, Embase, CINAHL, PsycINFO, LiLACS, regulatory agencies' websites, and international registers for published and unpublished, double-blind randomised controlled trials up to May 31, 2015, for the acute treatment of major depressive disorder in children and adolescents. We included trials of amitriptyline, citalopram, clomipramine, desipramine, duloxetine, escitalopram, fluoxetine, imipramine, mirtazapine, nefazodone, nortriptyline, paroxetine, sertraline, and venlafaxine. Trials recruiting participants with treatment-resistant depression, treatment duration of less than 4 weeks, or an overall sample size of less than ten patients were excluded. We extracted the relevant information from the published reports with a predefined data extraction sheet, and assessed the risk of bias with the Cochrane risk of bias tool. The primary outcomes were efficacy (change in depressive symptoms) and tolerability (discontinuations due to adverse events). We did pair-wise meta-analyses using the random-effects model and then did a random-effects network meta-analysis within a Bayesian framework. We assessed the quality of evidence contributing to each network estimate using the GRADE framework. This study is registered with PROSPERO, number CRD42015016023.


FINDINGS
We deemed 34 trials eligible, including 5260 participants and 14 antidepressant treatments. The quality of evidence was rated as very low in most comparisons. For efficacy, only fluoxetine was statistically significantly more effective than placebo (standardised mean difference -0·51, 95% credible interval [CrI] -0·99 to -0·03). In terms of tolerability, fluoxetine was also better than duloxetine (odds ratio [OR] 0·31, 95% CrI 0·13 to 0·95) and imipramine (0·23, 0·04 to 0·78). Patients given imipramine, venlafaxine, and duloxetine had more discontinuations due to adverse events than did those given placebo (5·49, 1·96 to 20·86; 3·19, 1·01 to 18·70; and 2·80, 1·20 to 9·42, respectively). In terms of heterogeneity, the global I(2) values were 33·21% for efficacy and 0% for tolerability.


INTERPRETATION
When considering the risk-benefit profile of antidepressants in the acute treatment of major depressive disorder, these drugs do not seem to offer a clear advantage for children and adolescents. Fluoxetine is probably the best option to consider when a pharmacological treatment is indicated.


FUNDING
National Basic Research Program of China (973 Program).
Beyond process monitoring: a proof-of-concept of event-driven business activity management

monitoring: a proof-of-concept of event-driven business activity management. Structured Abstract: Purpose. The purpose of this paper is to show how to employ complex event processing (CEP) for the observation and management of business processes. It proposes a conceptual architecture of BPM event producer, processor, and consumer and describes technical implications for the application with standard software in a perfect order scenario. Design/methodology/approach. The authors discuss business process analytics as the technological background. The capabilities of CEP in a BPM context are outlined an architecture design is proposed. A sophisticated proof-of-concept demonstrates its applicability. Findings. The results overcome the separation and data latency issues of process controlling, monitoring, and simulation. Distinct analyses of past, present, and future blur into a holistic real-time approach. The authors highlight the necessity for configurable event producer in BPM engines, process event support in CEP engines, a common process event format, connectors to visualizers, notifiers and return channels to the BPM engine. Research limitations. Further research will thoroughly evaluate the approach in a variety of business settings. New concepts and standards for the architecture's building blocks will be needed to improve maintainability and operability. Practical implications. Managers learn how CEP can yield insights into business processes' operations. The paper illustrates a path to overcome inflexibility, latency, and missing feedback mechanisms of current process modeling and control solutions. Software vendors might be interested in the conceptualization and the described needs for further development. Originality/value. So far, there is no commercial CEP-based BPM solution which facilitates a round trip from insight to action as outlines. As major software vendors have begun developing solutions (BPM/BPA solutions), this paper will stimulate a debate between research and practice on suitable design and technology.
Artificial intelligence in medicine.

INTRODUCTION
Artificial intelligence is a branch of computer science capable of analysing complex medical data. Their potential to exploit meaningful relationship with in a data set can be used in the diagnosis, treatment and predicting outcome in many clinical scenarios.


METHODS
Medline and internet searches were carried out using the keywords 'artificial intelligence' and 'neural networks (computer)'. Further references were obtained by cross-referencing from key articles. An overview of different artificial intelligent techniques is presented in this paper along with the review of important clinical applications.


RESULTS
The proficiency of artificial intelligent techniques has been explored in almost every field of medicine. Artificial neural network was the most commonly used analytical tool whilst other artificial intelligent techniques such as fuzzy expert systems, evolutionary computation and hybrid intelligent systems have all been used in different clinical settings.


DISCUSSION
Artificial intelligence techniques have the potential to be applied in almost every field of medicine. There is need for further clinical trials which are appropriately designed before these emergent techniques find application in the real clinical setting.
A Survey on Internet of Things: Security and Privacy Issues

This paper introduces Internet of Things (IoTs), which offers capabilities to identify and connect worldwide physical objects into a unified system. As a part of IoTs, serious concerns are raised over access of personal information pertaining to device and individual privacy. This survey summarizes the security threats and privacy concerns of IoT..
How an Australian Retailer Enabled Business Transformation Through Enterprise Architecture

1 Sia Siew Kien, Michael Rosemann and Phillip Yetton are the accepting senior editors for this article. 2 This research was partly funded by an Australian Research Council Discovery grant. The authors are grateful to the interviewees, whose willingness to share their valuable insights and experiences made this study possible, and to the senior editors and reviewers for their very helpful feedback and advice throughout the review process. 3 All quotes in this article are from employees of “RetailCo,” the subject of this case study. The names of the organization and its business divisions have been anonymized. 4 A digital business platform is “an integrated set of electronic business processes and the technologies, applications and data supporting those processes” Weill, P. and Ross, J. W. IT Savvy: What Top Executives Must Know to Go from Pain to Gain, Harvard Business School Publishing, 2009, p. 4; for more on digitized platforms, see pp. 67-87 of this publication. How an Australian Retailer Enabled Business Transformation Through Enterprise Architecture
Effects of acupuncture-like transcutaneous electrical nerve stimulation on children with asthma.

OBJECTIVE
To evaluate the effects of acupuncture-like transcutaneous electrical nerve stimulation (AL-TENS) on children with asthma.


METHODS
After an 8-week run-in period, the experimental group were assigned to treatment with AL-TENS, whereas the control group did not receive AL-TENS. A total of 43 children with asthma were recruited from a hospital and an elementary school. All the cases had been diagnosed as having asthma by physicians. The outcome measures included pulmonary function tests (PFTs), heart rate turbulence (HRT), heart rate variability (HRV), and pediatric asthma quality-of-life questionnaire (PAQLQ).


RESULTS
After 8 weeks of AL-TENS, there were no significant differences on forced vital capacity (FVC), FEV₁/FVC, and peak expiratory flows (PEFs) between the two groups. The HRT is the physiological, biphasic response of the sinus node to premature ventricular contractions. In the experimental group, the mean HRT was statistically significant between pretest and posttest. The HRV and the PAQLQ showed no difference, but in the experimental group, the subscale of the PAQLQ (particularly activity) improved significantly more than the pretest scores. Furthermore, there were no differences in PFTs and HRV after 8 weeks of AL-TENS between the two groups.


CONCLUSIONS
The PAQLQ activities of the experimental group improved significantly more than those of the control group. Reasons may include: 1) the asthma cases were stable and the cases were on stable status and 2) the degree of airway remodeling was less. It is suggested that in the future, treatment frequency and the long-term follow-up for evaluating the effects of AL-TENS on children with asthma should also be considered.
The Measured Impact of Vehicle Mass on Road Load F

The U.S. Department of Energy’s Office of Energy Efficiency & Renewable Energy initiated a study that conducted coastdown testing and chassis dynamometer testing of three vehicles, each at multiple test weights, in an effort to determine the impact of a vehicle’s mass on road load force and energy consumption. The testing and analysis also investigated the sensitivity of the vehicle’s powertrain architecture (i.e., conventional internal combustion powertrain, hybrid electric, or all-electric) on the magnitude of the impact of vehicle mass. The three vehicles used in testing are a 2012 Ford Fusion V6, a 2012 Ford Fusion Hybrid, and a 2011 Nissan Leaf. Testing included coastdown testing on a test track to determine the drag forces and road load at each test weight for each vehicle. Many quality measures were used to ensure only mass variations impact the road load measurements. Chassis dynamometer testing was conducted over standard drive cycles on each vehicle at multiple test weights to determine the fuel consumption or electrical energy consumption impact caused by change in vehicle mass. The road load measurements obtained from the coastdown testing were used to configure the chassis dynamometer. Chassis dynamometer testing also incorporated many quality controls to ensure accurate results. The results of the testing and analysis showed that for a given vehicle, the road load shows a slightly non-linear trend of decreasing road load with decreasing mass. This trend appears to be consistent across vehicle powertrain architectures (i.e., conventional powertrain, hybrid electric, or all-electric). Chassis dynamometer testing of fuel consumption or electrical energy consumption showed for the Highway Fuel Economy Test drive cycle there was little impact due to change in mass for all three vehicles. For the Urban Dynamometer Drive Schedule and US06 drive cycle, there was a 2.4 to 4.1% change in energy consumption for a 10% change in mass. Additionally, the less efficient the vehicle’s powertrain, the larger the energy consumption benefits were for mass reduction.
Microarray analysis of nemorosone-induced cytotoxic effects on pancreatic cancer cells reveals activation of the unfolded protein response (UPR).

BACKGROUND AND PURPOSE
Pancreatic cancer is one of the leading cancer-related causes of death due to high chemo-resistance and fast metastasation. Nemorosone, a polycyclic polyprenylated acylphloroglucinol, has recently been identified as a promising anticancer agent. Here, we examine its growth-inhibitory effects on pancreatic cancer cells. Based on transcription profiling, a molecular mode of action is proposed.


EXPERIMENTAL APPROACH
Nemorosone cytotoxicity was assessed by the resazurin proliferation assay on pancreatic cancer cells and fibroblasts. Apoptosis was determined by Annexin V/propidium iodide staining as well as cytochrome c and caspase activation assays. Staining with the voltage-dependent dye JC-1 and fluorescence microscopy were used to detect effects on mitochondrial membrane potential. Total RNA was isolated from treated cell lines and subjected to microarray analysis, subsequent pathway identification and modelling. Gene expression data were validated by quantitative polymerase chain reaction and siRNA-mediated gene knock-down.


KEY RESULTS
Nemorosone significantly inhibited cancer cell growth, induced cytochrome c release and subsequent caspase-dependent apoptosis, rapidly abolished mitochondrial membrane potential and elevated cytosolic calcium levels, while fibroblasts were largely unaffected. Expression profiling revealed 336 genes to be affected by nemorosone. A total of 75 genes were altered in all three cell lines, many of which were within the unfolded protein response (UPR) network. DNA damage inducible transcript 3 was identified as a key regulator in UPR-mediated cell death.


CONCLUSIONS AND IMPLICATIONS
Nemorosone could be a lead compound for the development of novel anticancer drugs amplifying the already elevated UPR level in solid tumours, thus driving them into apoptosis. This study forms the basis for further investigations identifying nemorosone's direct molecular target(s).
Архетипы политического сознания современного российского общества

The author examines the dynamics of the political consciousness of the contemporary Russian society and marcs out the principal traits that are specific for Russian society. The influence and the significance of the principal conservative ideas in the Russian society are shown.