LLukas22/scidocs huggingface dataset:
Factors that influence awareness of breast cancer screening among Arab women in Qatar: results from a cross sectional survey.

BACKGROUND
Breast cancer is the most common cancer among women in the State of Qatar. Due to low participation in breast cancer screening (BCS) activities, women in Qatar are often diagnosed with breast cancer at advanced stages of the disease. Findings indicate that low participation rates in BCS activities are significantly related to women's low level of awareness of breast cancer screening. The objectives of this study were to: (1) determine the factors that influence Qatari women's awareness of breast cancer and its screening activities: and (2) to find ways to effectively promote breast cancer screening activities among Arabic speaking women in Qatar.


MATERIALS AND METHODS
A multicenter, cross-sectional quantitative survey of 1,063 (87.5% response rate) female Qatari citizens and non-Qatari Arabic-speaking residents, 35 years of age or older, was conducted in Qatar from March 2011 to July 2011. Outcome measures included participant awareness levels of the most recent national recommended guidelines of BCS, participation rates in BCS activities, and factors related to awareness of BCS activities.


RESULTS
While most participants (90.7%) were aware of breast cancer, less than half had awareness of BCS practices (28.9% were aware of breast self-examination and 41.8% of clinical breast exams, while 26.4% knew that mammography was recommended by national screening guidelines. Only 7.6% had knowledge of all three BCS activities). Regarding BCS practice, less than one-third practiced BCS appropriately (13.9% of participants performed breast self-examination (BSE) monthly, 31.3% had a clinical breast exam (CBE) once a year or once every two years, and 26.9% of women 40 years of age or older had a mammogram once every year or two years). Awareness of BCS was significantly related to BCS practice, education level, and receipt of information about breast cancer and/or BCS from a variety of sources, particularly doctors and the media.


CONCLUSIONS
The low levels of participation rates in BCS among Arab women in this study indicate a strong need to increase awareness of the importance of breast cancer screening in Qatari women. Without this awareness, compliance with the most recent breast cancer screening recommendations in Qatar will remain low. An increased effort to implement mass media and public health campaigns regarding the impact of breast cancer on women's health and the benefits of early detection of breast cancer must be coupled with an enhanced participation of health care providers in delivering this message to Qatar population.
Geospatial Big Data Handling Theory and Methods: A Review and Research Challenges

DTU Orbit (17/12/2018)  Geospatial Big Data Handling Theory and Methods: A Review and Research Challenges Big data has now become a strong focus of global interest that is increasingly attracting the attention of academia, industry, government and other organizations. Big data can be situated in the disciplinary area of traditional geospatial data handling theory and methods. The increasing volume and varying format of collected geospatial big data presents challenges in storing, managing, processing, analyzing, visualizing and verifying the quality of data. This has implications for the quality of decisions made with big data. Consequently, this position paper of the International Society for Photogrammetry and Remote Sensing (ISPRS) Technical Commission II (TC II) revisits the existing geospatial data handling methods and theories to determine if they are still capable of handling emerging geospatial big data. Further, the paper synthesises problems, major issues and challenges with current developments as well as recommending what needs to be developed further in the near future.
Revised title Approaches to climate change impact , adaptation and vulnerability assessment : towards a classification framework to serve decision-making Acknowledgements

Approaches to climate change impact, adaptation and vulnerability assessment: towards a classification framework to serve decision-making.
Development and validation of an asthma knowledge test for children 8-10 years of age.

BACKGROUND
Although there are many instruments available to measure asthma knowledge in adult populations, a search of the literature identified the lack of valid and reliable instruments to assess the asthma knowledge of pre-adolescent children. The aim of this study was to develop and validate an asthma knowledge test for children 8-10 years of age.


METHODS
Three strategies were used to achieve the study objective: develop and design the asthma knowledge test; establish the content validity of test items; and conduct a pilot study to examine the validity, reliability and user friendliness of the instrument in a sample of 151 primary school children.


RESULTS
A 24-item asthma knowledge test was developed based on selected items from the Newcastle Asthma Knowledge Questionnaire and supplemented with items from other instruments. Test items were worded to ensure they could be understood by 8- to 10-year-old children, and content validity confirmed by an expert panel. A pilot study demonstrated that the test was user friendly, generated responses that reflected varying degrees of item difficulty and produced scores on the test that discriminated between 'known groups'.


CONCLUSION
Findings from this study indicate that an asthma knowledge test designed for primary school-age children has considerable promise. With further refinement and testing, this test will provide a valid and reliable measure of asthma knowledge in children with and without asthma that can be used in a wide range of childhood asthma studies.
Neurolinguistic programming: a systematic review of the effects on health outcomes.

BACKGROUND
Neurolinguistic programming (NLP) in health care has captured the interest of doctors, healthcare professionals, and managers.


AIM
To evaluate the effects of NLP on health-related outcomes.


DESIGN AND SETTING
Systematic review of experimental studies.


METHOD
The following data sources were searched: MEDLINE, PsycINFO, ASSIA, AMED, CINAHL, Web of Knowledge, CENTRAL, NLP specialist databases, reference lists, review articles, and NLP professional associations, training providers, and research groups.


RESULTS
Searches revealed 1459 titles from which 10 experimental studies were included. Five studies were randomised controlled trials (RCTs) and five were pre-post studies. Targeted health conditions were anxiety disorders, weight maintenance, morning sickness, substance misuse, and claustrophobia during MRI scanning. NLP interventions were mainly delivered across 4-20 sessions although three were single session. Eighteen outcomes were reported and the RCT sample sizes ranged from 22 to 106. Four RCTs reported no significant between group differences with the fifth finding in favour of the NLP arm (F = 8.114, P<0.001). Three RCTs and five pre-post studies reported within group improvements. Risk of bias across all studies was high or uncertain.


CONCLUSION
There is little evidence that NLP interventions improve health-related outcomes. This conclusion reflects the limited quantity and quality of NLP research, rather than robust evidence of no effect. There is currently insufficient evidence to support the allocation of NHS resources to NLP activities outside of research purposes.
Epirubicin and docetaxel with or without capecitabine as neoadjuvant treatment for early breast cancer: final results of a randomized phase III study (ABCSG-24).

BACKGROUND
This randomized phase III trial compared pathologic complete response (pCR) rates of early breast cancer (EBC) following neoadjuvant epirubicin-docetaxel (ED)±capecitabine (C), and evaluated the addition of trastuzumab in HER2-positive tumors.


PATIENTS AND METHODS
Patients with invasive breast cancer (except T4d) were randomly assigned to receive six 3-weekly cycles of ED (both 75 mg/m2)±C (1000 mg/m2, twice daily, days 1-14). Patients with HER2-positive disease were further randomized to receive trastuzumab (8 mg/kg, then 6 mg/kg every 3 weeks) or not. Primary end point: pCR rate at the time of surgery.


RESULTS
Five hundred thirty-six patients were randomized to ED (n=266) or EDC (n=270); 93 patients were further randomized to trastuzumab (n=44) or not (n=49). pCR rate was significantly increased with EDC (23.0% versus 15.4% ED, P=0.027), and nonsignificantly further increased with trastuzumab (38.6% EDC versus 26.5% ED, P=0.212). Rates of axillary node involvement at surgery and breast conservation were improved with EDC versus ED, but not significantly; the addition of trastuzumab had no further impact. Hormone receptor status, tumor size, grade, and C (all P≤0.035) were independent prognostic factors for pCR. Trastuzumab added to ED±C significantly increased the number of serious adverse events (35 versus 18; P=0.020), mainly due to infusion-related reactions.


CONCLUSION
These findings show that the integration of C into a neoadjuvant taxane-/anthracycline-based regimen is a feasible, safe, and effective treatment option, with incorporation of trastuzumab in HER2-positive disease.


CLINICAL TRIAL NUMBER
NCT00309556, www.clinicaltrials.gov.
There Is No Good Reason Not to Be Good

What is the relationship between sustained corporate social performance and corporate financial performance? This study uses five measures of risk to evaluate financial performance and compares them to KLD ratings of firm social performance. Results show that bondholders are helped by positive social performance and are harmed by negative social performance. Other financial stakeholders are unaffected.
Impact of soluble fms-like tyrosine kinase-1 and placental growth factor serum levels for risk stratification and early diagnosis in patients with suspected acute myocardial infarction.

AIMS
Angiogenic factors play an important role in the development of atherosclerosis and show pronounced changes during acute myocardial infarction (AMI). We analysed the impact of placental growth factor (PlGF) and its endogen opponent, soluble fms-like tyrosine kinase-1 (sFlt-1), on clinical outcome and the early diagnosis of AMI.


METHODS AND RESULTS
This multicentre study enrolled patients presenting with symptoms suggestive of AMI. The final diagnosis was adjudicated by two independent physicians. Levels of sFlt-1 and PlGF were compared with results of a standard troponin T and a novel high-sensitive troponin (hsTnT) assay. Of the 763 patients enrolled, 132 were diagnosed with AMI. Multivariable Cox regression analysis demonstrated sFlt-1 >84 ng/L [hazard ratios (HR) 2.6, 95% confidence intervals (CI) 1.2-5.4, P=0.01] and PlGF >20 ng/L (HR 3.6, 95% CI 1.3-10.4, P=0.02) as predictors for mortality during 1-year follow-up, independent from information provided by troponin T and N-terminal pro-B-type natriuretic peptide (NT-proBNP). However, only sFlt-1 persisted as independent predictor for mortality when analysed together with hsTnT and NT-proBNP, and after adjusting for significant clinical parameters. For the diagnosis of AMI, the combination of troponin T and sFlt-1 improved the performance of troponin T alone and led to a negative predictive value of 98.3% already at time of presentation. However, sFlt-1 and PlGF added only limited diagnostic information when used together with hsTnT.


CONCLUSION
Only sFlt-1 but not PlGF provides overall independent prognostic information in patients presenting with symptoms suggestive of AMI. After the introduction of hsTnT in clinical routine, sFlt-1 and PlGF can only add limited diagnostic information for the detection or exclusion of AMI.


CLINICAL TRIAL REGISTRATION INFORMATION
ClinicalTrials.gov, NCT00470587.
A Long Term Review of Surgically Treated Enlarged Breasts

Introduction: Breast hypertrophy (excessive enlargement of breast), a condition though rare, is well pronounced in some females. Surgery either by reduction mammaplasty or sub-cutaneous mastectomy is often employed in treatment of this condition. Aim: This study seeks to find out the long term level of satisfaction of the surgery on these persons after about 10 12 years after treatment. Materials and Methods: From January 1994 to December 2000, the Komfo Anokye Teaching Hospital (KATH) carried out surgeries on 43 females who presented with several degrees of breast hypertrophy. Patients were asked to answer questionnaires on their condition pre-operatively and post-operatively during the long term review process. Results: Thirty-four (79.1%) patients out of the 43 were available for the review with the patients stating there was much (100%) improvement in terms of the pain they felt in the neck, upper and lower back regions. There was no re-occurrence of the condition in any of the patients; 29 (85.3%) stated they were satisfied and that their new breast size(s) was/were excellent for them. Conclusion: The pre-operative complications experienced by these patients were resolved hence this surgical procedure was good and the quality of life of these persons had been improved.
Sequential Hybrid Procedure for Persistent Atrial Fibrillation

BACKGROUND
Catheter ablation of persistent atrial fibrillation yields an unsatisfactorily high number of failures. The hybrid approach has recently emerged as a technique that overcomes the limitations of both surgical and catheter procedures alone.


METHODS AND RESULTS
We investigated the sequential (staged) hybrid method, which consists of a surgical thoracoscopic radiofrequency ablation procedure followed by radiofrequency catheter ablation 6 to 8 weeks later using the CARTO 3 mapping system. Fifty consecutive patients (mean age 62±7 years, 32 males) with long-standing persistent atrial fibrillation (41±34 months) and a dilated left atrium (>45 mm) were included and prospectively followed in an unblinded registry. During the electrophysiological part of the study, all 4 pulmonary veins were found to be isolated in 36 (72%) patients and a complete box-lesion was confirmed in 14 (28%) patients. All gaps were successfully re-ablated. Twelve months after the completed hybrid ablation, 47 patients (94%) were in normal sinus rhythm (4 patients with paroxysmal atrial fibrillation required propafenone and 1 patient underwent a redo catheter procedure). The majority of arrhythmias recurred during the first 3 months. Beyond 12 months, there were no arrhythmia recurrences detected. The surgical part of the procedure was complicated by 7 (13.7%) major complications, while no serious adverse events were recorded during the radiofrequency catheter part of the procedure.


CONCLUSIONS
The staged hybrid epicardial-endocardial treatment of long-standing persistent atrial fibrillation seems to be extremely effective in maintenance of normal sinus rhythm compared to radiofrequency catheter or surgical ablation alone. Epicardial ablation alone cannot guarantee durable transmural lesions.


CLINICAL TRIAL REGISTRATION
URL: www.ablace.cz Unique identifier: cz-060520121617.
Note on the Franciscan metamorphism

Rocks of the Franciscan formation suffered a type of glaucophanitic regional metamorphism, being widely exposed in the Coast Ranges in California. The geological and petrological characters of the Franciscan metamorphism are outlined.
Lack of replication of higher genetic risk load in men than in women with systemic lupus erythematosus

INTRODUCTION
We aimed to replicate a recent study which showed higher genetic risk load at 15 loci in men than in women with systemic lupus erythematosus (SLE). This difference was very significant, and it was interpreted as indicating that men require more genetic susceptibility than women to develop SLE.


METHODS
Nineteen SLE-associated loci (thirteen of which are shared with the previous study) were analyzed in 1,457 SLE patients and 1,728 healthy controls of European ancestry. Genetic risk load was calculated as sex-specific sum genetic risk scores (GRS(s)).


RESULTS
Our results did not replicate those of the previous study at either the level of individual loci or the global level of GRS(s). GRS(s) were larger in women than in men (4.20 ± 1.07 in women vs. 3.27 ± 0.98 in men). This very significant difference (P < 10(-16)) was more dependent on the six new loci not included in the previous study (59% of the difference) than on the thirteen loci that are shared (the remaining 41%). However, the 13 shared loci also showed a higher genetic risk load in women than in men in our study (P = 6.6 × 10(-7)), suggesting that heterogeneity of participants, in addition to different loci, contributed to the opposite results.


CONCLUSION
Our results show the lack of a clear trend toward higher genetic risk in one of the sexes for the analyzed SLE loci. They also highlight several limitations of assessments of genetic risk load, including the possibility of ascertainment bias with loci discovered in studies that have included mainly women.
A framework to develop a clinical learning culture in health facilities: ideas from the literature.

BACKGROUND
Internationally, there is an increase in demand to educate nurses within the clinical practice environment. Clinical practice settings that encourage teaching and learning during episodes of care delivery can be powerful in educating both the existing nursing workforce and nursing students.


AIM
This paper presents a framework, informed by the literature, that identifies the key factors that are needed to encourage the interactions fundamental to learning in clinical practice.


KEY CONCEPTS
Learning occurs when nurses demonstrate good practice, share their knowledge through conversations and discussions, and also provide feedback to learners, such as students and novices. These types of interactions occur when positive leadership practices encourage trust and openness between staff; when the management team provides sessions for staff to learn how to interact with learners, and also when partnerships provide support and guidance around learning in the workplace. APPLICATION OF CONCEPTS: This framework presents how the concepts of leadership, management and partnership interact to create and sustain learning environments. The feedback from proposed measurement tools can provide valuable information about the positive and negative aspects of these concepts in the clinical learning environment. Analysis of the subscales can assist in identifying appropriate recommended strategies outlined in the framework to guide nurses in improving the recognized deficits in the relationship between the concepts.


CONCLUSION
Leadership, management and partnerships are pivotal for the creation and maintenance of positive learning environments. Diagnostic measurement tools can provide specific information about weaknesses across these areas. This knowledge can guide future initiatives.
Evaluation of Random Forest and Adaboost tree-based ensemble classification and spectral band selection for ecotope mapping using airborne hyperspectral imagery

In most cases authors are permitted to post their version of the article (e.g. in Word or Tex form) to their personal website or institutional repository. Authors requiring further information regarding Elsevier's archiving and manuscript policies are encouraged to visit: a r t i c l e i n f o a b s t r a c t Detailed land use/land cover classification at ecotope level is important for environmental evaluation. In this study, we investigate the possibility of using airborne hyperspectral imagery for the classification of ecotopes. In particular, we assess two tree-based ensemble classification algorithms: Adaboost and Random Forest, based on standard classification accuracy, training time and classification stability. Our results show that Adaboost and Random Forest attain almost the same overall accuracy (close to 70%) with less than 1% difference, and both outperform a neural network classifier (63.7%). Random Forest, however, is faster in training and more stable. Both ensemble classifiers are considered effective in dealing with hyperspectral data. Furthermore, two feature selection methods, the out-of-bag strategy and a wrapper approach feature subset selection using the best-first search method are applied. A majority of bands chosen by both methods concentrate between 1.4 and 1.8 μm at the early shortwave infrared region. Our band subset analyses also include the 22 optimal bands between 0.4 and 2.5 μm suggested in Thenkabail et al. (2004). Accuracy assessments of hyperspectral waveband performance for vegetation analysis applications. Remote Sensing of Environment, 91, 354–376.] due to similarity of the target classes. All of the three band subsets considered in this study work well with both classifiers as in most cases the overall accuracy dropped only by less than 1%. A subset of 53 bands is created by combining all feature subsets and comparing to using the entire set the overall accuracy is the same with Adaboost, and with Random Forest, a 0.2% improvement. The strategy to use a basket of band selection methods works better. Ecotopes belonging to the tree classes are in general classified better than the grass classes. Small adaptations of the classification scheme are recommended to improve the applicability of remote sensing method for detailed ecotope mapping. 1. Introduction Land use/land cover classification is a generic tool for environmental monitoring. To measure subtle changes in the ecosystem, a land use/land cover classification at ecotope level with definitive biological and ecological characteristics is needed. Ecotopes are distinct ecological landscape features …
A high content screening assay for identifying lysosomotropic compounds.

Lysosomes are acidic organelles that are essential for the degradation of old organelles and engulfed microbes. Furthermore, lysosomes play a key role in cell death. Lipophilic or amphiphilic compounds with a basic moiety can become protonated and trapped within lysosomes, causing lysosomal dysfunction. Therefore, high-throughput screens to detect lysosomotropism, the accumulation of compounds in lysosomes, are desirable. Hence, we developed a 96-well format, high content screening assay that measures lysosomotropism and cytotoxicity by quantitative image analysis. Forty drugs, including antidepressants, antipsychotics, antiarrhythmics and anticancer agents, were tested for their effects on lysosomotropism and cytotoxicity in H9c2 cells. The assay correctly identified drugs known to cause lysosomotropism and revealed novel information showing that the anticancer drugs, gefitinib, lapatinib, and dasatinib, caused lysosomotropism. Although structurally and pharmacologically diverse, drugs that were lysosomotropic shared certain physicochemical properties, possessing a ClogP>2 and a basic pKa between 6.5 and 11. In contrast, drugs which did not lie in this physicochemical property space were not lysosomotropic. The assay is a robust, rapid screen that can be used to identify lysosomotropic, as well as, cytotoxic compounds, and can be positioned within a screening paradigm to understand the role of lysosomotropism as a contributor to drug-induced toxicity.