LLukas22/scidocs huggingface dataset:
The comparison and validity of troponin I assay systems in diagnosing myocardial ischemic injury after surgical coronary revascularization.

OBJECTIVE
A prospective observational study was conducted to test the agreement between 2 commercially available automated cardiac troponin-I immunoassay systems (Opus Plus, Behring Diagnostics UK Ltd, Hounslow, UK; AxSYM, Abbott Laboratories, Abbott Park, IL) and to determine a normal reference range and threshold value indicative of perioperative myocardial infarction (PMI) after elective coronary artery bypass graft (CABG) surgery for the Opus Plus system.


DESIGN
Prospective, observational study. Setting : Single institution, cardiothoracic specialty hospital.


PARTICIPANTS
Seventy patients undergoing elective CABG surgery.


INTERVENTIONS
After institutional review board approval, patients received standardized anesthetic, surgical, and myocardial preservation techniques. Serial electrocardiographs, creatine kinase-MB, troponin-I, and perioperative outcome data were collected. Correlation between the immunoassay systems was tested using 124 duplicate samples from the first 18 patients. The normal reference range and threshold value indicative of PMI were tested for the Opus Plus system using duplicate samples from all 70 patients.


MEASUREMENTS AND MAIN RESULTS
Peak troponin-I concentrations (median [interquartile range]) differed significantly when measured by the Opus Plus and AxSYM immunoassay systems (5.61 [3.20-22.35] microg/L v 46.50 [14.55-70.95] microg/L, respectively; p < 0.001). There was clear proportional bias that was corrected with log transformation of the raw data. By using confidence interval and receiver operating characteristic curve analysis, the authors showed that a value > or =15 mug/L was indicative of PMI (Opus Plus system) and accordingly report a 35.7% (2.9% Q-wave) overall incidence of PMI in this study population (n = 70).


CONCLUSIONS
These data highlight differences between commercially available troponin-I assay systems. The authors recommend that each institution establish a local reference range and threshold indicative of perioperative myocardial infarction for its specific patient population and assay system and provide sample methodology.
A Randomized Trial of High-Flow Oxygen Therapy in Infants with Bronchiolitis.

BACKGROUND
High-flow oxygen therapy through a nasal cannula has been increasingly used in infants with bronchiolitis, despite limited high-quality evidence of its efficacy. The efficacy of high-flow oxygen therapy through a nasal cannula in settings other than intensive care units (ICUs) is unclear.


METHODS
In this multicenter, randomized, controlled trial, we assigned infants younger than 12 months of age who had bronchiolitis and a need for supplemental oxygen therapy to receive either high-flow oxygen therapy (high-flow group) or standard oxygen therapy (standard-therapy group). Infants in the standard-therapy group could receive rescue high-flow oxygen therapy if their condition met criteria for treatment failure. The primary outcome was escalation of care due to treatment failure (defined as meeting ≥3 of 4 clinical criteria: persistent tachycardia, tachypnea, hypoxemia, and medical review triggered by a hospital early-warning tool). Secondary outcomes included duration of hospital stay, duration of oxygen therapy, and rates of transfer to a tertiary hospital, ICU admission, intubation, and adverse events.


RESULTS
The analyses included 1472 patients. The percentage of infants receiving escalation of care was 12% (87 of 739 infants) in the high-flow group, as compared with 23% (167 of 733) in the standard-therapy group (risk difference, -11 percentage points; 95% confidence interval, -15 to -7; P<0.001). No significant differences were observed in the duration of hospital stay or the duration of oxygen therapy. In each group, one case of pneumothorax (<1% of infants) occurred. Among the 167 infants in the standard-therapy group who had treatment failure, 102 (61%) had a response to high-flow rescue therapy.


CONCLUSIONS
Among infants with bronchiolitis who were treated outside an ICU, those who received high-flow oxygen therapy had significantly lower rates of escalation of care due to treatment failure than those in the group that received standard oxygen therapy. (Funded by the National Health and Medical Research Council and others; Australian and New Zealand Clinical Trials Registry number, ACTRN12613000388718 .).
Pierre Duhem and the history of philosophy of science

Pierre Duhem demonstrated that his ability to take new viewpoints was not limited to physical theory as he was also interested in the histories and philosophies of science.
New evidence from state panel data , 1977 to 2006

Research Summary Economists have recently reexamined the “capital punishment deters homicide” thesis using modern econometric methods, with most studies reporting robust deterrent effects. The current study revisits this controversial question using annual state panel data from 1977 to 2006. Employing well-known econometric procedures for panel data analysis, our results provide no empirical support for the argument that the existence or application of the death penalty deters prospective offenders from committing homicide.
Current-Fed Resonant Full-Bridge Boost DC/AC/DC Converter

This paper presents a current-fed full-bridge boost DC/AC/DC converter with transformer isolation operating without switching power dissipation. The output voltage is regulated by DC/AC converter control frequency changes with a constant turn-off time of transistors. The proposed converter is devoid of parasitic oscillations, as all of the parasitic capacitances and inductances are included in a resonant tank circuit. In this paper, the system operation is first explained, then a mathematical description that is useful for its design is provided, and finally, a report on the implementation of a laboratory prototype with 1.4-kW power is presented.
Out-of-Distribution Detection Using an Ensemble of Self Supervised Leave-Out Classifiers

As deep learning methods form a critical part in commercially important applications such as autonomous driving and medical diagnostics, it is important to reliably detect out-of-distribution (OOD) inputs while employing these algorithms. In this work, we propose an OOD detection algorithm which comprises of an ensemble of classifiers. We train each classifier in a self-supervised manner by leaving out a random subset of training data as OOD data and the rest as in-distribution (ID) data. We propose a novel margin-based loss over the softmax output which seeks to maintain at least a margin m between the average entropy of the OOD and in-distribution samples. In conjunction with the standard cross-entropy loss, we minimize the novel loss to train an ensemble of classifiers. We also propose a novel method to combine the outputs of the ensemble of classifiers to obtain OOD detection score and class prediction. Overall, our method convincingly outperforms Hendrycks et al. [7] and the current state-of-the-art ODIN [13] on several OOD detection benchmarks.
Business process management: a boundaryless approach to modern competitiveness

Introduction The literature on business process re-engineering, benchmarking, continuous improvement and many other approaches of modern management is very abundant. One thing which is noticeable, however, is the growing usage of the word “process” in everyday business language. This suggests that most organizations adopt a process-based approach to managing their operations and that business process management (BPM) is a well-established concept. Is this really what takes place? On examination of the literature which refers to BPM, it soon emerged that the use of this concept is not really pervasive and what in fact has been acknowledged hitherto as prevalent business practice is no more than structural changes, the use of systems such as EN ISO 9000 and the management of individual projects.
Fundamental Switching Frequency Optimal Pulsewidth Modulation of Medium-Voltage Cascaded Seven-Level Inverter

Multilevel converters (MLCs) emerged as standard solutions for medium voltage (MV) high-power industrial ac drives. MV drives require low device switching frequency operation due to the higher switching losses of semiconductor devices. However, low device switching frequency operation leads to an increase in the harmonic distortion of machine stator currents. Therefore, there is a need to implement low switching frequency modulation technique for MLCs, which does not compromise on the harmonic distortion of machine currents. The goal of this paper is to propose a new optimal pulsewidth modulation technique for a cascaded seven level (7L) inverter such that the maximum device switching frequency is limited to the rated fundamental frequency (50/60 Hz) and all power semiconductor devices operate at identical switching frequency. Optimal switching patterns were determined offline assuming steady-state conditions. Later, switching angles for each semiconductor device are determined and stored in an FPGA controller. A low-power prototype of the 7L cascade inverter has been developed to demonstrate the proposed modulation technique. The experimental results demonstrated that the proposed optimal modulation technique maintains the quality of machine stator currents while the device switching frequency is limited to the rated fundamental frequency.
Intermittent Blood Flow in Solid Tumours – an under-appreciated Source of ‘drug Resistance’

As the search for improved anti-cancer drugs continues, new paradigms concerning the reasons for clinical failures in common human solid tumours are also evolving. Classical drug resistance is now perhaps less often invoked to explain lack of treatment efficacy than are newer concepts, including ‘contact resistance’, ‘tumour heterogeneity’, ‘regrowth resistance’, and ‘physiological barriers’ to drug delivery. This commentary will explore the resistance of solid tumours to chemotherapy from yet another, largely ignored perspective: that of tumour-specific fluctuations in blood flow. Transient decreases in blood flow have significant implications for delivery of chemotherapeutic agents, cellular responsiveness to those agents, and the regrowth potential of the surviving tumour cells.
Mutation rates of 15 X chromosomal short tandem repeat markers

Though allele frequency data for a variety of X chromosomal short tandem repeat (STR) markers in a range of populations have been reported, fewer studies of mutation rates in these same markers or populations are available. In order to address possible mismatches during kinship analysis due to mutation, a robust estimate of the rate of mutation must be established. Here, mutation rates in three US populations have been determined for a total of 15 markers (DXS6789, DXS9902, DXS7132, DXS7130, DXS6795, DXS10147, DXS8378, DXS7423, HPRTB, DXS101, DXS7424, GATA31E08, GATA172D05, GATA165B12, and DXS6803). Eighteen mutations over 20,625 meioses were observed, and the overall X STR mutation rate in this study was found to be 8.73 × 10−4 (95 % CI, 5.2–13.8 × 10−4). A review of published mutation rate studies revealed similar findings in other global populations, and allowed the compilation of a combined dataset of 81,310 meioses which can be employed by the forensic community.
Mobile phone applications in Parkinson's disease: A systematic review.

INTRODUCTION
Parkinson's disease (PD) is the second most common neurodegenerative disease. However, diagnosing, assessing, and treating these patients is a complex process requiring continuous monitoring. In this context, smartphones may be useful in the management of patients with PD.


OBJECTIVE
The purpose of this study is to perform a systematic review of the literature addressing the use of mobile phone applications (apps) in PD.


MATERIALS AND METHODS
We conducted a literature search of articles published in English or Spanish between 2011 and 2016 analysing or validating apps specifically designed for or useful in PD. In addition, we searched for apps potentially useful for PD patients in the leading app stores.


CONCLUSIONS
The literature and app searches yielded a total of 125 apps, 56 of which were classified as potentially useful in PD and 69 as specifically designed for PD (23 information apps, 29 assessment apps, 13 treatment apps, and 4 assessment and treatment apps). Numerous mobile apps are potentially useful in or specifically designed for PD management. However, scientific evidence of their usefulness is scarce and of poor quality. Further studies are needed to validate these tools and regulate their use.
The Discriminative validity of "nociceptive," "peripheral neuropathic," and "central sensitization" as mechanisms-based classifications of musculoskeletal pain.

OBJECTIVES
Empirical evidence of discriminative validity is required to justify the use of mechanisms-based classifications of musculoskeletal pain in clinical practice. The purpose of this study was to evaluate the discriminative validity of mechanisms-based classifications of pain by identifying discriminatory clusters of clinical criteria predictive of "nociceptive," "peripheral neuropathic," and "central sensitization" pain in patients with low back (± leg) pain disorders.


METHODS
This study was a cross-sectional, between-patients design using the extreme-groups method. Four hundred sixty-four patients with low back (± leg) pain were assessed using a standardized assessment protocol. After each assessment, patients' pain was assigned a mechanisms-based classification. Clinicians then completed a clinical criteria checklist indicating the presence/absence of various clinical criteria.


RESULTS
Multivariate analyses using binary logistic regression with Bayesian model averaging identified a discriminative cluster of 7, 3, and 4 symptoms and signs predictive of a dominance of "nociceptive," "peripheral neuropathic," and "central sensitization" pain, respectively. Each cluster was found to have high levels of classification accuracy (sensitivity, specificity, positive/negative predictive values, positive/negative likelihood ratios).


DISCUSSION
By identifying a discriminatory cluster of symptoms and signs predictive of "nociceptive," "peripheral neuropathic," and "central" pain, this study provides some preliminary discriminative validity evidence for mechanisms-based classifications of musculoskeletal pain. Classification system validation requires the accumulation of validity evidence before their use in clinical practice can be recommended. Further studies are required to evaluate the construct and criterion validity of mechanisms-based classifications of musculoskeletal pain.
HfO/sub 2/ and lanthanide-doped HfO/sub 2/ MIM capacitors for RF/mixed IC applications

We demonstrate high quality HfO/sub 2/-metal-insulator-metal (MIM) capacitors with a high capacitance of 4.7 fF/cm/sup 2/ and a leakage current density of less than 10/sup -8/ A/cm/sup 2/, meeting ITRS requirement for analog precision capacitor applications. In addition, we demonstrate that doping HfO/sub 2/ with Lanthanide (Tb) at an optimum concentration improves both voltage linearity and leakage current density of HfO/sub 2/ MIM capacitor, allowing further reduction of insulator thickness and achieving a capacitance density of 13.3 fF//spl mu/m/sup 2/ with leakage current meeting requirements for RF bypass capacitors applications. These values are superior to that reported in the literature, suggesting the potential use of these dielectrics for future RF/mixed signal IC applications.
PARAMETERS ESTIMATION FOR A MODEL OF PHOTOVOLTAIC PANELS

− The paper describes the first results of a simulation and characterization tool useful to evaluate electrical performances of photovoltaic (PV) panels. A simple one-diode model is used in order to estimate the electrical parameters of a PV panel and predict how the I-V characteristic changes with environmental parameters such as temperature and irradiance. This work is part of a wider project whose final purpose is to model a whole PV plant in order to control its performances in various environmental conditions and maximize the energy production. The continuous monitoring of a plant and the comparison between real and expected data will also greatly reduce the risk of out of order. The used model is implemented as a MATLAB script which yields the I-V and P-V characteristics of the PV panel under test. The model has been validated against an experimentally characterized PV panel. Some parameters of the model have been measured directly (irradiance and temperature) whereas others have been evaluated in two distinct ways: by means of direct computation on the data sheet or by means of best-fit on the measured data, and the results have been compared.
Towards an Integrated View of Learning From Text and Visual Displays

Visuo-spatial text adjuncts such as static or animated pictures, geographic maps, thematic maps, graphs, and knowledge maps that have been analyzed in the articles contained in this special issue provide complex pictorial information that complements the verbal information of texts. These spatial text adjuncts are considered as depictive representations that can support communication, thinking, and learning. An essential precondition of this supportive function is that the visuo-spatial displays interact appropriately with human visual perception and the individual’s cognitive system, which is characterized by prior knowledge, cognitive abilities, and learning skills. Accordingly, effective learning with visuo-spatial text adjuncts can be fostered by instructional design and by adequate processing strategies, both dependent on sufficient understanding of how the human cognitive system interacts with these displays. Perspectives for further research in this area are provided.
Localized image watermarking based on feature points of scale-space representation

This paper proposes a novel method for content-based watermarking based on feature points of an image. At each feature point, the watermark is embedded after scale normalization according to the local characteristic scale. Characteristic scale is the maximum scale of the scale-space representation of an image at the feature point. By binding watermarking with the local characteristics of an image, resilience against a5ne transformations can be obtained easily. Experimental results show that the proposed method is robust against various image processing steps including a5ne transformations, cropping, 7ltering and JPEG compression. ? 2004 Pattern Recognition Society. Published by Elsevier Ltd. All rights reserved.
Using human physiology to evaluate subtle expressivity of a virtual quizmaster in a mathematical game

The aim of the experimental study described in this article is to investigate the effect of a lifelike character with subtle expressivity on the affective state of users. The character acts as a quizmaster in the context of a mathematical game. This application was chosen as a simple, and for the sake of the experiment, highly controllable, instance of human–computer interfaces and software. Subtle expressivity refers to the character’s affective response to the user’s performance by emulating multimodal human–human communicative behavior such as different body gestures and varying linguistic style. The impact of em-pathic behavior, which is a special form of affective response, is examined by deliberately frustrating the user during the game progress. There are two novel aspects in this investigation. First, we employ an animated interface agent to address the affective state of users rather than a text-based interface, which has been used in related research. Second, while previous empirical studies rely on questionnaires to evaluate the effect of life-like characters, we utilize physiological information of users (in addition to questionnaire data) in order to precisely associate the occurrence of interface events with users’ autonomic nervous system activity. The results of our study indicate that empathic character response can significantly decrease user stress see front matter r 2004 Elsevier Ltd. All rights reserved. .ijhcs.2004.11.009 cle is a significantly revised and extended version of Prendinger et al. (2003). nding author. Tel.: +813 4212 2650; fax: +81 3 3556 1916. dresses: helmut@nii.ac.jp (H. Prendinger), jmori@miv.t.u-tokyo.ac.jp (J. Mori), v.t.u-tokyo.ac.jp (M. Ishizuka).
Transformation knowledge in pattern analysis with kernel methods: distance and integration kernels

Modern techniques for data analysis and machine learning are so called kernel methods. The most famous and successful one is represented by the support vector machine (SVM) for classification or regression tasks. Further examples are kernel principal component analysis for feature extraction or other linear classifiers like the kernel perceptron. The fundamental ingredient in these methods is the choice of a kernel function, which computes a similarity measure between two input objects. For good generalization abilities of a learning algorithm it is indispensable to incorporate problem-specific a-priori knowledge into the learning process. The kernel function is an important element for this. This thesis focusses on a certain kind of a-priori knowledge namely transformation knowledge. This comprises explicit knowledge of pattern variations that do not or only slightly change the pattern’s inherent meaning e.g. rigid movements of 2D/3D objects or transformations like slight stretching, shifting, rotation of characters in optical character recognition etc. Several methods for incorporating such knowledge in kernel functions are presented and investigated. 1. Invariant distance substitution kernels (IDS-kernels): In many practical questions the transformations are implicitly captured by sophisticated distance measures between objects. Examples are nonlinear deformation models between images. Here an explicit parameterization would require an arbitrary number of parameters. Such distances can be incorporated in distanceand inner-product-based kernels. 2. Tangent distance kernels (TD-kernels): Specific instances of IDS-kernels are investigated in more detail as these can be efficiently computed. We assume differentiable transformations of the patterns. Given such knowledge, one can construct linear approximations of the transformation manifolds and use these efficiently for kernel construction by suitable distance functions. 3. Transformation integration kernels (TI-kernels): The technique of integration over transformation groups for feature extraction can be extended to kernel functions and more general group, non-group, discrete or continuous transformations in a suitable way. Theoretically, these approaches differ in the way the transformations are represented and in the adjustability of the transformation extent. More fundamentally, kernels from category 3 turn out to be positive definite, kernels of types 1 and 2 are not positive definite, which is generally required for being usable in kernel methods. This is the
Pinned mid-points multilevel inverter (PMP): Three-phase topology with high voltage levels and one bidirectional switch

High power applications need high efficiency devices to produce lower power losses and harmonics while meeting the limitation of voltage and current. Multilevel inverters generate smoother and higher voltage at the output with lower harmonics. They can deliver high power while using medium-voltage switches. In this paper a Pinned Mid-Points (PMP) multilevel inverter topology is introduced and studied which is derived from a Bidirectional Neutral Point Clamped (BNPC) three-level inverter. The proposed PMP multilevel inverter has fewer switches and clamping diodes than the Cascaded H-bridge (CHB) and Neutral Point Clamped (NPC) inverters, moreover it has less bidirectional switches in comparison with the BNPC. Moreover, it can be extended to three-phase inverter same as a NPC only using three legs and common DC link. A five-level inverter using proposed topology is validated by Matlab/SimPowerSystems. It shows the appropriate results of voltage and current as well as their THD%.