LLukas22/scidocs huggingface dataset:
Headstrong: a pilot study of a CD-ROM intervention for recurrent pediatric headache.

OBJECTIVES
To empirically evaluate a minimal therapist contact CD-ROM pain management program for recurrent pediatric headache developed as part of this study.


METHODS
Participants were 37 children aged 7-12 attending a pediatric neurology clinic for evaluation of recurrent headache. Children who were randomly assigned to the treatment group worked through the CD-ROM program on home computers for 4 weeks following baseline assessment, whereas those assigned to the wait-list group continued following the prescriptions of their neurologist. Data on daily headache activity and headache-related disability were collected at baseline and up to 3 months after treatment.


RESULTS
Children who received the adjunctive CD-ROM program had significant improvements in headache activity above and beyond those in the control group. Results provide initial support for the utility of adding an adjunctive CD-ROM psychological intervention to standard medical care for recurrent pediatric headache and potentially other chronic pain conditions in children.
Direct costs of opioid abuse in an insured population in the United States.

OBJECTIVE
To (a) describe the demographics of opioid abusers; (b) compare the prevalence rates of selected comorbidities and the medical and drug utilization patterns of opioid abusers with patients from a control group, for the period from 1998 to 2002; and (c) calculate the mean annual per-patient total health care costs (e.g., inpatient, outpatient, emergency room, drug, other) from the perspective of a private payer.


METHODS
An administrative database of medical and pharmacy claims from 1998 to 2002 of 16 self-insured employer health plans with approximately 2 million lives was used to identify "opioid abusers"--patients with claims associated with ICD-9-CM (International Classification of Diseases, 9th Revision, Clinical Modification) codes for opioid abuse (304.0, 304.7, 305.5, and 965.0 [excluding 965.01]). A control group of nonabusers was selected using a matched sample (by age, gender, employment status, and census region) in a 3:1 ratio. Per-patient annual health care costs (mean total medical and drug costs) were measured in 2003 U.S. dollars. Multivariate regression techniques were also used to control for comorbidities and to compare costs with a benchmark of depressed patients.


RESULTS
740 patients were identified as opioid abusers, a prevalence of 8 in 10,000 persons aged 12 to 64 years continuously enrolled in health care plans for whom 12 months of data were available for calculating costs. Opioid abusers, compared with nonabusers, had significantly higher prevalence rates for a number of specific comorbidities, including nonopioid poisoning, hepatitis (A, B, or C), psychiatric illnesses, and pancreatitis, which were approximately 78, 36, 9, and 21 (P<0.01) times higher, respectively, compared with nonabusers. Opioid abusers also had higher levels of medical and prescription drug utilization. Almost 60% of opioid abusers had prescription drug claims for opioids compared with approximately 20% for nonabusers. Prevalence rates for hospital inpatient visits for opioid abusers were more than 12 times higher compared with nonabusers (P<0.01). Mean annual direct health care costs for opioid abusers were more than 8 times higher than for nonabusers ($15,884 versus $1,830, respectively, P < 0.01). Hospital inpatient and physician-outpatient costs accounted for 46% ($7,239) and 31% ($5,000) of opioid abusers. health care costs, compared with 17% ($310) and 50% ($906), respectively, for nonabusers. Mean drug costs for opioid abusers were more than 5 times higher than costs for nonabusers ($2,034 vs. $386, respectively, P<0.01), driven by higher drug utilization (including opioids) for opioid abusers. Even when controlling for comorbidities using a multivariate regression model of a matched control of depressed patients, the average health care costs of opioid abusers were 1.8 times higher than the average health care costs of depressed patients.


CONCLUSION
The high costs of opioid abuse were driven primarily by high prevalence rates of costly comorbidites and high utilization rates of medical services and prescription drugs.
RoarNet: A Robust 3D Object Detection based on RegiOn Approximation Refinement

We present RoarNet, a new approach for 3D object detection from 2D image and 3D Lidar point clouds. Based on two stage object detection framework ([1], [2]) with PointNet [3] as our backbone network, we suggest several novel ideas to improve 3D object detection performance. The first part of our method, RoarNet 2D, estimates the 3D poses of objects from a monocular image, which approximates where to examine further, and derives multiple candidates that are geometrically feasible. This step significantly narrows down feasible 3D regions, which otherwise requires demanding processing of 3D point clouds in a huge search space. Then the second part, RoarNet 3D, takes the candidate regions and conducts in-depth inferences to conclude final poses in a recursive manner. Inspired by PointNet, RoarNet 3D processes 3D point clouds directly without any loss of data, leading to precise detection. We evaluate our method in KITTI, a 3D object detection benchmark. Our result shows that RoarNet has superior performance to state-of-the-art methods that are publicly available. Remarkably, RoarNet also outperforms state-of-the-art methods even in settings where Lidar and camera are not time synchronized, which is practically important for actual driving environment. RoarNet is implemented in Tensorflow [4] and publicly available with pretrained models.
Economic analysis of a transesophageal echocardiography-guided approach to cardioversion of patients with atrial fibrillation: the ACUTE economic data at eight weeks.

OBJECTIVES
The aim of this study was to compare the relative cost of a transesophageal echocardiography (TEE)-guided strategy versus conventional strategy for patients with atrial fibrillation (AF) >2 days duration undergoing electrical cardioversion over an eight-week period.


BACKGROUND
The Assessment of Cardioversion Using Transesophageal Echocardiography (ACUTE) trial found no difference in embolic rates between the two approaches. However, the TEE-guided strategy had a shorter time to cardioversion and a lower rate of composite bleeding. While similar clinical efficacy was concluded, the relative cost of these two strategies has not been explored.


METHODS
Two economic approaches were employed in the ACUTE trial. The first approach was based on hospital charge data from complete hospital Universal Billing Code of 1992 forms, a detailed hospital charge questionnaire, or imputation. Regression analysis was used to investigate the added cost of adverse events. The second economic approach involved the development of an independent analytic model simulating treatment and actual ACUTE outcome costs as a validation of clinically derived data. Sensitivity analysis was performed on the analytic model to investigate the potential range in cost differences between the strategies.


RESULTS
A total of 833 of the 1,222 patients were enrolled from 53 U.S. sites; TEE-guided (n = 420) and conventional (n = 413). At eight-week follow-up, total mean costs did not significantly differ between the two groups, respectively (6,508 dollars vs. 6,239 dollars; difference of 269 dollars; p = 0.50). Cumulative costs were 24% higher in the conventional group, primarily due to increased incidence of bleeding and hospital costs associated with bleeding. A separate analytic model showed that treatment costs were higher for the TEE-guided strategy, but outcome costs were higher for the conventional strategy. Sensitivity analysis of the analytic model illustrated that varying the incidence and cost of major bleeding and the cost of TEE had the greatest impact on cost differences between the two groups.


CONCLUSIONS
In patients with AF >2 days duration undergoing electrical cardioversion, the TEE-guided group showed little difference in patient costs compared with the conventional group. The TEE strategy had higher initial treatment costs but lower outcome-associated costs. Cumulative costs were 24% higher in the conventional group, primarily due to bleeding. The TEE-guided strategy is an economically feasible approach compared with the conventional strategy.
How to switch to agomelatine after an unsuccessful try with paroxetine or venlafaxine.

OBJECTIVE/INTRODUCTION
The present trial informs clinicians about switching conditions with the antidepressant agomelatine after the failure of a treatment with either paroxetine or venlafaxine.


METHODS
The total number of discontinuation-emergent symptoms, according to the Discontinuation-Emergent Signs and Symptoms checklist, was compared in double-blind conditions after 3 switching options: immediate substitution or initiation of agomelatine (25 mg/day p.o.) with either a short- or long-tapering of the previous drug. Secondary objectives included tolerability and safety assessments and the early clinical benefit after the switch.


RESULTS
For all switching options, a withdrawal syndrome was observed 1 week after cessation of the selective serotonin reuptake inhibitor (SSRI)/serotonin-norepinephrine reuptake inhibitor (SNRI) treatment. Psychic symptoms were the most frequently reported, and somatic symptoms were comparatively few. Early discontinuation symptoms after cessation of SSRI/SNRI treatment did not prejudice the antidepressant benefits of agomelatine over 8 weeks.


CONCLUSIONS
Both abrupt and start-taper switching with agomelatine are options in everyday practice for those patients who have not responded to either paroxetine or venlafaxine. However, regardless of the switching strategy, the present double-blind study shows that early discontinuation symptoms that arise upon cessation of SSRI/SNRI can alter the patients' perception of the clinical benefit of the new antidepressant. Both practitioners and patients must be warned about these early discontinuation symptoms to prevent the symptoms from being confounded with a lack of therapeutic benefit of the new treatment.
A Reinforcement-Learning-Based Assisted Power Management With QoR Provisioning for Human–Electric Hybrid Bicycle

In this paper, a reinforcement-learning-based assisted power management (RLAPM) with quality-of-riding (QoR) provisioning is proposed for the human-electric hybrid bicycle or the pedelec, which is a light electric vehicle (LEV) driven mainly by human's pedal force with the assisted force from a battery-powered electric motor. By learning from the changes in the riding environment, the proposed RLAPM adaptively dispatches appropriate assisted motor power to support the rider in meeting the QoR requirement, i.e., safety and comfort, of the pedelec. With the RLAPM, not only pedelec rider's QoR is guaranteed, but energy utilization of battery is improved as well. Simulations of the RLAPM and the RLAPM enhancement (RLAPME) for the pedelec are performed under different road types. Experimental results demonstrate that the achievability of the comfort riding of the RLAPME is improved by 24%, while the energy utilization is improved by 50% by comparing with other existing assisted power methods for the pedelec in urban riding.
Keep It Simple and Sparse: Real-Time Action Recognition

Sparsity has been showed to be one of the most important properties for visual recognition purposes. In this paper we show that sparse representation plays a fundamental role in achieving one-shot learning and real-time recognition of actions. We start off from RGBD images, combine motion and appearance cues and extract state-of-the-art features in a computationally efficient way. The proposed method relies on descriptors based on 3D Histograms of Scene Flow (3DHOFs) and Global Histograms of Oriented Gradient (GHOGs); adaptive sparse coding is applied to capture high-level patterns from data. We then propose a simultaneous on-line video segmentation and recognition of actions using linear SVMs. The main contribution of the paper is an effective realtime system for one-shot action modeling and recognition; the paper highlights the effectiveness of sparse coding techniques to represent 3D actions. We obtain very good results on three different data sets: a benchmark data set for one-shot action learning (the ChaLearn Gesture Data Set), an in-house data set acquired by a Kinect sensor including complex actions and gestures differing by small details, and a data set created for human-robot interaction purposes. Finally we demonstrate that our system is effective also in a human-robot interaction setting and propose a memory game, “All Gestures You Can”, to be played against a humanoid robot.
Equivalences for Free ! Univalent

ANONYMOUS AUTHOR(S) Homotopy Type Theory promises a unification of the concepts of equality and equivalence in Type Theory, through the introduction of the univalence principle. However, existing proof assistants based on type theory treat this principle as an axiom, and it is not yet clear how to extend them to handle univalence internally. In this paper, we propose a construction grounded on a univalent version of parametricity to bring the benefits of univalence to the programmer and prover, that can be used on top of existing type theories. In particular, univalent parametricity strengthens parametricity to ensure preservation of type equivalences. We present a lightweight framework implemented in the Coq proof assistant that allows the user to transparently transfer definitions and theorems for a type to an equivalent one, as if they were equal. Our approach handles both type and term dependency. We study how to maximize the effectiveness of these transports in terms of computational behavior, and identify a fragment useful for certified programming on which univalent transport is guaranteed to be effective.
All-solid-state pulse adder with bipolar high voltage fast narrow pulses output

A newly developed bipolar high voltage adder is proposed for generating fast narrow pulses. The new circuit topology enables the use of typical half-bridge semiconductor structures on the basis of conventional unipolar all-solid-state pulse adder. Magnetic ring transformers were employed for isolating the charge loop from the high-voltage pulse discharge loop, which simplified the isolation arrangement. Certain measures were implemented to resolve the EMI caused by the pulse adder arrangement. A laboratory prototype was assembled with 8 stages and each stage was made of 800 V MOSFETs. The modulator operating at 21 kHz repetition rate gives 2 kV bipolar pulses, with 200 ns positive/negative pulse widths, 37 ns rise time, 50 ns fall time, and 40 ns relaxation time into a 50 Ω resistive load. The adopted design is an all-solid-state approach with a simple control method, long maintenance-free lifetime, and high reliability.
Transcutaneous versus blood carbon dioxide monitoring during acute noninvasive ventilation in the emergency department - a retrospective analysis.

QUESTIONS UNDER STUDY
Transcutaneous measurement of carbon dioxide (PtCO2) has been suggested as an alternative to invasively obtained PaCO2 for the monitoring of patients with hypercapnic respiratory failure during noninvasive ventilation (NIV). Current data on monitoring in hypoxaemic respiratory failure are scarce and show conflicting results in hypercapnic patients in the emergency department.


METHODS AND SETTING
We performed a retrospective comparison of real-time PtCO2 (SenTec Digital Monitor) and arterial/venous carbon dioxide tension (PaCO2/PvCO2) measurements in patients with severe hypoxaemic and/or hypercapnic respiratory failure during NIV. Agreement between PtCO2 and PaCO2/PvCO2 was the primary endpoint. Bland-Altman analysis and linear regression were used.


RESULTS
102 patients had at least one matched measurement of PtCO2 and PaCO2/PvCO2. For patients with arterial blood gas analysis, the mean difference was 0.46 kPa at baseline (95% confidence interval [CI] 0.23 to 0.60, limits of agreement 95% CI -0.54 to 1.45) and 0.12 kPa after NIV (95% CI -0.04 to 0.29, limits of agreement 95% CI: -0.61 to 0.86). The linear regression analysis found a correlation R2 of 0.88 (p <0.001) at baseline and an R2 of 0.99 (p <0.001) after initiating NIV. For patients with venous blood gas analysis, the mean difference was 0.64 kPa at baseline (95% CI 0.04 to 1.24, limits of agreement 95% CI -0.72 to 2) and 0.80 kPa after NIV (95% CI 0.51 to 1.10, limits of agreement 95% CI 0.29 to 1.32), R2 0.78 (p <0.001) at baseline and R2 0.91 (p <0.001) after initiating NIV. A PaCO2/PvCO2 >8 kPa was associated with a lesser degree of agreement between the levels of PtCO2 and PaCO2/PvCO2 (p <0.001).


CONCLUSION
Transcutaneous PCO2 monitoring shows a good concordance with PaCO2 and is a reliable, feasible, patient-friendly and safe alternative to repeated blood gas analysis for patients with severe hypoxaemic and/or hypercapnic respiratory failure receiving emergency NIV in the emergency department. An initial blood gas analysis to evaluate the respiratory and metabolic state and to rule out a significant discrepancy compared with the transcutaneous measurement is recommended.
Optimizing low side gate resistance for damping phase node ringing of synchronous buck converter

This paper presents a method to optimize gate resistance of low side MOSFET in terms of damping phase node ringing for high efficiency synchronous buck converter. This method analyzes damping effect of low side gate resistance in the network of parasitic capacitances of MOSFET die and parasitic inductances of MOSFET package. Optimization equations for low side gate resistance are derived based on parasitic inductances and capacitances. Experiment proves the validity of this optimization design for low side gate resistance.
Моральная несостоятельность и правовая утопия юридического (этатического) позитивизма

The article is devoted to the study of the subject and the methodological principles of the legal (etatic) positivism. We study the history of the development of this scientific law school as an example of legal concepts such famous scientists as Y. Bentam, J.S. Mill, J. Austin, G.Kelzen. The article draws attention to the pursuit of legal positivism simplify issues related to the nature of law and law-making, in order to achieve a minimum social justice, which leads to a number of serious contradictions in the legal concept.
Polar Coding Without Alphabet Extension for Asymmetric Models

This paper considers polar coding for asymmetric settings, that is, channel coding for asymmetric channels and lossy source coding for nonuniform sources and/or asymmetric distortion measures. The difficulty for asymmetric settings comes from the fact that the optimal symbol distributions of codewords are not always uniform. It is known that such nonuniform distributions can be realized by Gallager's scheme which maps multiple auxiliary symbols distributed uniformly to an actual symbol. However, the complexity of Gallager's scheme increases considerably for the case that the optimal distribution cannot be approximated by simple rational numbers. To overcome this problem for the asymmetric settings, a new polar coding scheme is proposed, which can attain the channel capacity without any alphabet extension by invoking results on polar coding for lossless compression. It is also shown that the proposed scheme achieves a better tradeoff between complexity and decoding error probability in many cases.
Identifying the critical factors that influence intraocular pressure using an automated regression tree

Copyright: © 2017. The Author(s). Licensee: AOSIS. This work is licensed under the Creative Commons Attribution License. Introduction Glaucoma is an optic neuropathy that sometimes results in irreversible blindness.1 After cataracts, glaucoma is the second most prevalent cause of global blindness,2 and it is estimated that almost 80 million people worldwide will be affected by this optic neuropathy by the year 2020.3 Because of the high prevalence of this ocular disease, the economic and social implications of glaucoma have been outlined in recent studies.4,5 In Africa, primary open-angle glaucoma (POAG) is more prevalent than primary-angle closure glaucoma, and over the next 4 years, the prevalence of POAG in Africa is projected to increase by 23% corresponding to an increase from 6.2 million to 8.0 million affected individuals.3 Consequently, in Africa, there have been recommendations to incorporate glaucoma screening procedures into routine eye examinations as well as implement glaucoma blindness control programs.6,7
A tutorial on variational Bayesian inference

This tutorial describes the mean-field variational Bayesian approximation to inference in graphical models, using modern machine learning terminology rather than statistical physics concepts. It begins by seeking to find an approximate mean-field distribution close to the target joint in the KL-divergence sense. It then derives local node updates and reviews the recent Variational Message Passing framework.
Endothelial-dependent Mechanisms Regulate Leukocyte Transmigration: A Process Involving the Proteasome and Disruption of the Vascular Endothelial–Cadherin Complex at Endothelial Cell-to-Cell Junctions 

Although several adhesion molecules expressed on leukocytes (beta1 and beta2 integrins, platelet endothelial cell adhesion molecule 1 [PECAM-1], and CD47) and on endothelium (intercellular adhesion molecule 1, PECAM-1) have been implicated in leukocyte transendothelial migration, less is known about the role of endothelial lateral junctions during this process. We have shown previously (Read, M.A., A.S. Neish, F.W. Luscinskas, V.J. Palambella, T. Maniatis, and T. Collins. 1995. Immunity. 2:493-506) that inhibitors of the proteasome reduce lymphocyte and neutrophil adhesion and transmigration across TNF-alpha-activated human umbilical vein endothelial cell (EC) monolayers in an in vitro flow model. The current study examined EC lateral junction proteins, principally the vascular endothelial (VE)-cadherin complex and the effects of proteasome inhibitors (MG132 and lactacystin) on lateral junctions during leukocyte adhesion, to gain a better understanding of the role of EC junctions in leukocyte transmigration. Both biochemical and indirect immunofluorescence analyses of the adherens junction zone of EC monolayers revealed that neutrophil adhesion, not transmigration, induced disruption of the VE-cadherin complex and loss of its lateral junction localization. In contrast, PECAM-1, which is located at lateral junctions and is implicated in neutrophil transmigration, was not altered. These findings identify new and interrelated endothelial-dependent mechanisms for leukocyte transmigration that involve alterations in lateral junction structure and a proteasome-dependent event(s).