LLukas22/scidocs huggingface dataset:
Associations of dairy intake with glycemia and insulinemia, independent of obesity, in Brazilian adults: the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).

BACKGROUND
Inverse associations between dairy intake and the risk of type 2 diabetes have been shown, but more studies are needed, especially from low- and middle-income countries.


OBJECTIVE
The objective was to describe the association between dairy products and direct measures of glycemic status in adults without known diabetes.


DESIGN
The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) includes 15,105 adults, aged 35-74 y, enrolled from universities and research institutions in 6 Brazilian capital cities. We excluded participants with a known diabetes diagnosis, cardiovascular diseases, and cancer. Dairy consumption was assessed by a food-frequency questionnaire, and we computed servings per day for total and subgroups of dairy. Associations with fasting blood glucose (FG) and fasting insulin, 2-h postload glucose (PG), 2-h postload insulin (PI), glycated hemoglobin (Hb A1c), and homeostasis model assessment of insulin resistance (HOMA-IR) were assessed through multivariable linear regression analysis with adjustment for demographic characteristics, behavioral risk factors, other dietary factors, and anthropometric measurements.


RESULTS
The sample size after exclusions was 10,010. The intake of total dairy was inversely associated with FG (linear β for dairy servings/d = -0.46 ± 0.2 mg/dL), PG (-1.25 ± 0.5 mg/dL), PI (-1.52 ± 0.6 mg/dL), Hb A1c (-0.02 ± 0.0%), and HOMA-IR (-0.04 ± 0.0) after adjustment for all covariates (P < 0.05 for all). The findings were consistent across categories of sex, race, obesity status, and dairy fat amount (reduced-fat vs. full-fat dairy). Fermented dairy products showed particularly strong inverse associations with the outcomes, with adjusted differences for a 1-serving/d increment of -0.24 (95% CI: -0.46, -0.02) mg/dL for FG, -0.86 (-1.42, -0.30) mg/dL for PG, and -0.01% (-0.02%, 0.00%) for Hb A1c. Myristic acid was the only nutrient that appeared to mediate the association between dairy intake and glycemia.


CONCLUSION
Dairy intake, especially fermented dairy, was inversely associated with measures of glycemia and insulinemia in Brazilian adults without diagnosed diabetes. This trial was registered at clinicaltrials.com as NCT02320461.
Reduced-Intensity Transplantation for Lymphomas Using Haploidentical Related Donors Versus HLA-Matched Sibling Donors: A Center for International Blood and Marrow Transplant Research Analysis.

PURPOSE
Related donor haploidentical hematopoietic cell transplantation (Haplo-HCT) using post-transplantation cyclophosphamide (PT-Cy) is increasingly used in patients lacking HLA-matched sibling donors (MSD). We compared outcomes after Haplo-HCT using PT-Cy with MSD-HCT in patients with lymphoma, using the Center for International Blood and Marrow Transplant Research registry.


MATERIALS AND METHODS
We evaluated 987 adult patients undergoing either Haplo-HCT (n = 180) or MSD-HCT (n = 807) following reduced-intensity conditioning regimens. The haploidentical group received graft-versus-host disease (GVHD) prophylaxis with PT-Cy with or without a calcineurin inhibitor and mycophenolate. The MSD group received calcineurin inhibitor-based GVHD prophylaxis.


RESULTS
Median follow-up of survivors was 3 years. The 28-day neutrophil recovery was similar in the two groups (95% v 97%; P = .31). The 28-day platelet recovery was delayed in the haploidentical group compared with the MSD group (63% v 91%; P = .001). Cumulative incidence of grade II to IV acute GVHD at day 100 was similar between the two groups (27% v 25%; P = .84). Cumulative incidence of chronic GVHD at 1 year was significantly lower after Haplo-HCT (12% v 45%; P < .001), and this benefit was confirmed on multivariate analysis (relative risk, 0.21; 95% CI, 0.14 to 0.31; P < .001). For Haplo-HCT v MSD-HCT, 3-year rates of nonrelapse mortality (15% v 13%; P = .41), relapse/progression (37% v 40%; P = .51), progression-free survival (48% v 48%; P = .96), and overall survival (61% v 62%; P = .82) were similar. Multivariate analysis showed no significant difference between Haplo-HCT and MSD-HCT in terms of nonrelapse mortality (P = .06), progression/relapse (P = .10), progression-free survival (P = .83), and overall survival (P = .34).


CONCLUSION
Haplo-HCT with PT-Cy provides survival outcomes comparable to MSD-HCT, with a significantly lower risk of chronic GVHD.
The comparative effectiveness of Integrated treatment for Substance abuse and Partner violence (I-StoP) and substance abuse treatment alone: a randomized controlled trial

BACKGROUND
Research has shown that treatments that solely addressed intimate partner violence (IPV) perpetration were not very effective in reducing IPV, possibly due to neglecting individual differences between IPV perpetrators. A large proportion of IPV perpetrators is diagnosed with co-occurring substance use disorders and it has been demonstrated that successful treatment of alcohol dependence among alcohol dependent IPV perpetrators also led to less IPV. The current study investigated the relative effectiveness of Integrated treatment for Substance abuse and Partner violence (I-StoP) to cognitive behavioral treatment addressing substance use disorders including only one session addressing partner violence (CBT-SUD+) among patients in substance abuse treatment who repeatedly committed IPV. Substance use and IPV perpetration were primary outcome measures.


METHOD
Patients who entered substance abuse treatment were screened for IPV. Patients who disclosed at least 7 acts of physical IPV in the past year (N = 52) were randomly assigned to either I-StoP or CBT-SUD+. Patients in both conditions received 16 treatment sessions. Substance use and IPV perpetration were assessed at pretreatment, halfway treatment and posttreatment in blocks of 8 weeks. Both completers and intention-to-treat (ITT) analyses were performed.


RESULTS
Patients (completers and ITT) in both conditions significantly improved regarding substance use and IPV perpetration at posttreatment compared with pretreatment. There were no differences in outcome between conditions. Completers in both conditions almost fully abstained from IPV in 8 weeks before the end of treatment.


CONCLUSIONS
Both I-StoP and CBT-SUD+ were effective in reducing substance use and IPV perpetration among patients in substance abuse treatment who repeatedly committed IPV and self-disclosed IPV perpetration. Since it is more cost and time-effective to implement CBT-SUD+ than I-StoP, it is suggested to treat IPV perpetrators in substance abuse treatment with CBT-SUD+.
Single Electron Transistor : Applications and Limitations

Recent research in SET gives new ideas which are going to revolutionize the random access memory and digital data storage technologies. The goal of this paper is to discuss about the basic physics and applications of nano electronic device ‘Single electron transistor [SET]’ which is capable of controlling the transport of only one electron. Single-electron transistor (SET) is a key element of current research area of nanotechnology which can offer low power consumption and high operating speed. The single electron transistor is a new type of switching device that uses controlled electron tunneling to amplify current.
Residue management , conservation tillage and soil restoration for mitigating greenhouse effect by CO ,-enrichment

This manuscript reviews the potential impact of residue management, conservation tillage and soil restoration on carbon sequestration in world soils. The greenhouse effect is among four principal ecological issues of global concern that include: (i) adequacy of land resources to meet needs of present and future generations; (ii) role of world soils and agricultural practices in the ‘greenhouse’ effect; (iii) potential of crop residue management, restoration of degraded soils, and conservation tillage in carbon sequestration in soil; and (iv) minimizing risks of soil degradation by enhancing soil resilience and soil quality. Annual increase in CO, concentration in the atmosphere is 3.2 X 1015 g, and there exists a potential to mitigate this effect through C sequestration in soils. Just as world soils are an important active pool of organic carbon and play a major role in the global carbon cycle, crop residue is a major renewable resource which also has an important impact on the global carbon cycle. I have estimated the annual production of crop residue to be about 3.4 billion Mg in the world. If 15% of C contained in the residue can be converted to passive soil organic carbon (SOC) fraction, it may lead to C sequestration at the rate of 0.2 X lOI5 g/yr. Similarly restoring presently degraded soils, estimated at about 2.0 billion ha, and increasing SOC content by O.Ol%/yr may lead C sequestration at the rate of 3.0 Pg C/yr. Conservation tillage is an important tool for crop residue management, restoration of degraded soil, and for enhancing C sequestration in soil. Conservation tillage, any tillage system that maintains at least 30% of the soil surface covered by residue, was practised in 1995 on about 40 X lo6 ha or 35.5% of planted area in USA. It is projected that by the year 2020, conservation tillage may be adopted on 75% of cropland in USA (140 X IO6 ha), 50% in other developed countries (225 X lo6 ha), and 25% in developing countries (172 X lo6 ha). The projected conversion of conventional to conservation tillage may lead to a global C sequestration by 2020 at a low estimate of 1.5 X 1015 g, and at a high estimate of 4.9 X lOI g of C. These potentials of C ’ Corresponding author. 0167-1987/97/$17.00
Driver Distraction - A Review of the Literature

background, aim, method, result) max 200 words: Driver distraction has been defined in many different ways. The most important difference is whether only visual inattention or also cognitive inattention should be included. Many different methods have been used to assess the prevalence and types of driver distraction that occur, and to describe the consequences in terms of driving performance and crash involvement. There is strong agreement that distraction is detrimental for driving, and that the risk for crashes increases. Drivers rather opt for repeated glances instead of extending one single glance, if the secondary task demands attention for a longer period of time. However, repeated glances have more detrimental effects on driving performance than a single glance of the same duration as one of the repeated glances. Only recently the method of remote eye tracking has emerged, which enables real time identification of visual distraction. So far this method has mostly been used in driving simulators. Different algorithms that diagnose distracted drivers have been tested with promising results. In simulators it is difficult, however, to induce true distraction, due to the short duration of the experiment and the artificial setting. A prolonged field study under naturalistic conditions could provide new insights and validation of simulator studies.
Bioequivalence Studies of A Generic Formulation (SW651K) to the BrandDrug S-1 in Tumor-Bearing Rat Models

The generic anticancer drugs are developed in the field of anticancer therapy and are commercially available. Generally, the safety and efficacy of a brand anticancer drug are determined by phase 1, 2 and 3 clinical trials. In contrast, clinical trials are not necessarily required by guidelines for the development of generic drugs and are usually not performed. Pharmacokinetic equivalence is considered particularly important for cytotoxic anticancer drugs because of the narrow therapeutic window. Differences in the content and purity of active and inactive pharmaceutical ingredients might have an important impact on pharmacokinetics of the generic cytotoxic anticancer drug and cause the difference in the pharmacodynamics. However the bioequivalent studies of PK/PD using the tumor-bearing rat models had been hardly reported before.
State variability in supply of office-based primary care providers: United States, 2012.

KEY FINDINGS
Data from the National Ambulatory Medical Care Survey (NAMCS) and the NAMCS Electronic Health Records Survey In 2012, 46.1 primary care physicians and 65.5 specialists were available per 100,000 population. From 2002 through 2012, the supply of specialists consistently exceeded the supply of primary care physicians. Compared with the national average, the supply of primary care physicians was higher in Massachusetts, Rhode Island, Vermont, and Washington; it was lower in Arkansas, Georgia, Mississippi, Nevada, New Mexico, and Texas. In 2012, 53.0% of office-based primary care physicians worked with physician assistants or nurse practitioners. Compared with the national average, the percentage of physicians working with physician assistants or nurse practitioners was higher in 19 states and lower in Georgia. Primary care providers include primary care physicians, physician assistants, and nurse practitioners. Primary care physicians are those in family and general practice, internal medicine, geriatrics, and pediatrics (1). Physician assistants are state-licensed health professionals practicing medicine under a physician's supervision. Nurse practitioners are registered nurses (RNs) with advanced clinical training (2-6). The ability to obtain primary care depends on the availability of primary care providers (3). This report presents state estimates of the supply of primary care physicians per capita, as well as the availability of physician assistants or nurse practitioners in primary care physicians' practices. Estimates are based on data from the National Ambulatory Medical Care Survey (NAMCS), Electronic Health Records (EHR) Survey, a nationally representative survey of office-based physicians.
Implementing a Functional ISO 9001 Quality Management System in Small and Medium-Sized Enterprises

This conceptual paper provides guidance for the implementation of a functional ISO 9001 quality management system (QMS) in small and medium-sized enterprises (SMEs). To help a SME understand its starting point, four initial states for QMS implementation are defined. Five paths for moving the QMS from the initial state to the desired state are described. To support the transition from the initial to the desired state, some key considerations in implementing a QMS in SMEs are discussed. The paper is based on site visits and implementation assistance the authors have provided to several SMEs. It is anticipated the paper will help managers in SMEs understand the process of implementing ISO 9001 and help them avoid the development of a paper-driven QMS that provides limited value.
Evaluation of the antihypertensive efficacy and tolerability of moexipril, a new ACE inhibitor, compared to hydrochlorothiazide in elderly patients

Objective: To compare the antihypertensive efficacy of moexipril, a new angiotensin-converting enzyme (ACE) inhibitor, to treatment with hydrochlorothiazide (HCTZ). Patients: Two hundred and one non-hospitalized male and female patients between 65 and 80 years of age with essential hypertension. Methods: This was a multicentre, placebo-controlled, double-blind study with a parallel group design. Subjects with a sitting diastolic blood pressure (DBP) ≥ 95 mmHg were randomized to monotherapy with placebo, moexipril 7.5 mg o.d., moexipril 15 mg o.d. or HCTZ 25 mg o.d. for 8 weeks. Results: Throughout the study period treatment with moexipril and HCTZ resulted in significant reductions of DBP compared with placebo, but there were no significant differences between the active treatment groups. At end point the adjusted mean reductions were 10.5, 8.7 and 10.1 mmHg in the HCTZ, moexipril 7.5 mg and moexipril 15 mg groups, respectively, compared to 3.9 mmHg in the placebo group. Treatment with moexipril was associated with two cases of first dose hypotension and two cases of moderate and reversible increases in serum creatinine levels. Otherwise, both dosages of moexipril were well tolerated and the overall percentages of patients who had adverse experiences were smaller than in the placebo group. Conclusion: Moexipril is well tolerated and is at least as effective as HCTZ in elderly patients with essential hypertension.
Theory and Practice in Parallel Job Scheduling

Parallel job scheduling has gained increasing recognition in recent years as a distinct area of study. However , there is concern about the divergence of theory and practice in the eld. We review theoretical research in this area, and recommendations based on recent results. This is contrasted with a proposal for standard interfaces among the components of a scheduling system, that has grown from requirements in the eld.
Runoff and erosional responses to a drought ‐ induced shift in a desert grassland community composition

[1] This study investigates how drought‐induced change in semiarid grassland community affected runoff and sediment yield in a small watershed in southeast Arizona, USA. Three distinct periods in ecosystem composition and associated runoff and sediment yield were identified according to dominant species: native bunchgrass (1974–2005), forbs (2006), and the invasive grass, Eragrostis lehmanniana (2007–2009). Precipitation, runoff, and sediment yield for each period were analyzed and compared at watershed and plot scales. Average watershed annual sediment yield was 0.16 t ha yr. Despite similarities in precipitation characteristics, decline in plant canopy cover during the transition period of 2006 caused watershed sediment yield to increase 23‐fold to 1.64 t ha yr comparing with preceding period under native bunchgrasses (0.06 t ha yr) or succeeding period under E. lehmanniana (0.06 t ha yr). In contrast, measurements on small runoff plots on the hillslopes of the same watershed showed a significant increase in sediment discharge that continued after E. lehmanniana replaced native grasses. Together, these findings suggest alteration in plant community increased sediment yield but that hydrological responses to this event differ at watershed and plot scales, highlighting the geomorphological controls at the watershed scale that determine sediment transport efficiency and storage. Resolving these scalar issues will help identify critical landform features needed to preserve watershed integrity under changing climate conditions.
Clinical Implications of Cognitive Bias Modification for Interpretative Biases in Social Anxiety: An Integrative Literature Review

Cognitive theories of social anxiety indicate that negative cognitive biases play a key role in causing and maintaining social anxiety. On the basis of these cognitive theories, laboratory-based research has shown that individuals with social anxiety exhibit negative interpretation biases of ambiguous social situations. Cognitive Bias Modification for interpretative biases (CBM-I) has emerged from this basic science research to modify negative interpretative biases in social anxiety and reduce emotional vulnerability and social anxiety symptoms. However, it is not yet clear if modifying interpretation biases via CBM will have any enduring effect on social anxiety symptoms or improve social functioning. The aim of this paper is to review the relevant literature on interpretation biases in social anxiety and discuss important implications of CBM-I method for clinical practice and research.
MatrixFlow: Temporal Network Visual Analytics to Track Symptom Evolution during Disease Progression

OBJECTIVE
To develop a visual analytic system to help medical professionals improve disease diagnosis by providing insights for understanding disease progression.


METHODS
We develop MatrixFlow, a visual analytic system that takes clinical event sequences of patients as input, constructs time-evolving networks and visualizes them as a temporal flow of matrices. MatrixFlow provides several interactive features for analysis: 1) one can sort the events based on the similarity in order to accentuate underlying cluster patterns among those events; 2) one can compare co-occurrence events over time and across cohorts through additional line graph visualization.


RESULTS
MatrixFlow is applied to visualize heart failure (HF) symptom events extracted from a large cohort of HF cases and controls (n=50,625), which allows medical experts to reach insights involving temporal patterns and clusters of interest, and compare cohorts in novel ways that may lead to improved disease diagnoses.


CONCLUSIONS
MatrixFlow is an interactive visual analytic system that allows users to quickly discover patterns in clinical event sequences. By unearthing the patterns hidden within and displaying them to medical experts, users become empowered to make decisions influenced by historical patterns.
Fully process-compatible layout design on bond pad to improve wire bond reliability in CMOS ICs

During manufacture of wire bonding in packaged IC products, the breaking of bond wires and the peeling of bond pads occur frequently. The result is open-circuit failure in IC products. There were several prior methods reported to overcome these problems by using additional process flows or special materials. In this paper, a layout method is proposed to improve the bond wire reliability in general CMOS processes. By changing the layout patterns of bond pads, the reliability of bond wires on bond pads can be improved. A set of different layout patterns of bond pads has been drawn and fabricated in a 0.6-m single-poly triple-metal CMOS process for investigation by the bond wire reliability tests, the ball shear test and the wire pull test. By implementing effective layout patterns on bond pads in packaged IC products, not only the bond wire reliability can be improved, but also the bond pad capacitance can be reduced for high frequency application. The proposed layout method for bond pad design is fully process-compatible to general CMOS processes.
Restaurant Inspection Scores and Foodborne Disease

Restaurants in the United States are regularly inspected by health departments, but few data exist regarding the effect of restaurant inspections on food safety. We examined statewide inspection records from January 1993 through April 2000. Data were available from 167,574 restaurant inspections. From 1993 to 2000, mean scores rose steadily from 80.2 to 83.8. Mean inspection scores of individual inspectors were 69-92. None of the 12 most commonly cited violations were critical food safety hazards. Establishments scoring <60 had a mean improvement of 16 points on subsequent inspections. Mean scores of restaurants experiencing foodborne disease outbreaks did not differ from restaurants with no reported outbreaks. A variety of factors influence the uniformity of restaurant inspections. The restaurant inspection system should be examined to identify ways to ensure food safety.