LLukas22/scidocs huggingface dataset:
Do gender differences in primary PCI mortality represent a different adherence to guideline recommended therapy? a multicenter observation

BACKGROUND
It is uncertain whether gender differences in outcome after primary percutaneous coronary intervention (PCI) are only attributable to different baseline characteristics or additional factors.


METHODS
Databases of two German myocardial infarction network registries were combined with a total of 1104 consecutive patients admitted with acute ST-elevation myocardial infarction (STEMI) and treated according to standardized protocols.


RESULTS
Approximately 25% of patients were females. Mean age (69 vs 61 years), incidence of diabetes (28% vs 20%), hypertension (68 vs 58%) and renal insufficiency (26% vs 19%) was significantly higher compared to males. Mean prehospital delay was numerically longer in females (227 vs 209 min) as was in hospital delay (35 vs 30 min). PCI was finally performed in 92% of females and 95% of males with comparable procedural success (95% vs 97%). Use of drug eluting stents (55% vs 68%) and application of GP 2b 3a blockers (75% vs 89%) was significantly less frequent in women. At discharge, prescription of beta blockers and lipid lowering drugs was also significantly lower in females (84% vs 90% and 71% vs 84%). Unadjusted in-hospital mortality was significantly higher in females (10% vs 5%) without attenuation after 12 months. Adjusted mortality however did not differ significantly between genders.


CONCLUSION
Higher unadjusted mortality in females after primary PCI was accompanied by significant differences in baseline characteristics, interventional approach and secondary prophylaxis in spite of the same standard of care. Lower guideline adherence seems to be less gender specific but rather a manifestation of the risk-treatment paradox.
A Randomized, Controlled Study of Once-Daily LY2605541, a Novel Long-Acting Basal Insulin, Versus Insulin Glargine in Basal Insulin–Treated Patients With Type 2 Diabetes

OBJECTIVE
To evaluate whether LY2605541 results in lower fasting blood glucose (FBG) versus insulin glargine (GL).


RESEARCH DESIGN AND METHODS
This 12-week, randomized, open-label, Phase 2 study enrolled patients with type 2 diabetes (hemoglobin A(1c) [A1C] ≤ 10.5%), taking metformin and/or sulfonylurea with GL or NPH insulin once daily. Patients converted to morning insulin administration during lead-in were randomized 2:1 from GL (n = 248) or NPH insulin (n = 39) to LY2605541 (n = 195) or GL (n = 95) once daily in the morning.


RESULTS
At 12 weeks, FBG (mean ± SE) was similar with LY2605541 and GL (118.2 ± 2.0 mg/dL [6.6 ± 0.1 mmol/L] vs. 116.9 ± 2.7 mg/dL [6.5 ± 0.2 mmol/L], P = 0.433) as was A1C (7.0 ± 0.1 vs. 7.2 ± 0.1%, P = 0.279). Intraday blood glucose variability was reduced with LY2605541 (34.4 vs. 39.1 mg/dL [1.9 vs. 2.2 mmol/L], P = 0.031). LY2605541 patients had weight loss (-0.6 ± 0.2 kg, P = 0.007), whereas GL patients gained weight (0.3 ± 0.2 kg, P = 0.662; treatment difference: -0.8 kg, P = 0.001). The incidence and rate of both total hypoglycemia and nocturnal hypoglycemia were comparable between LY2605541 and GL, although, LY2605541 had a 48% reduction in nocturnal hypoglycemia after adjusting for baseline hypoglycemia (P = 0.021). Adverse events were similar across treatments. Alanine aminotransferase and aspartate aminotransferase remained within normal range but were significantly higher with LY2605541 (P ≤ 0.001).


CONCLUSIONS
In patients with type 2 diabetes, LY2605541 and GL had comparable glucose control and total hypoglycemia rates, but LY2605541 showed reduced intraday variability, lower nocturnal hypoglycemia, and weight loss relative to GL.
Hierarchies in Dictionary Definition Space

A dictionary defines words in terms of other words. Definitions can tell you the meanings of words you don’t know, but only if you know the meanings of the defining words. How many words do you need to know (and which ones) in order to be able to learn all the rest from definitions? We reduced dictionaries to their “grounding kernels” (GKs), about 10% of the dictionary, from which all the other words could be defined. The GK words turned out to have psycholinguistic correlates: they were learned at an earlier age and more concrete than the rest of the dictionary. But one can compress still more: the GK turns out to have internal structure, with a strongly connected “kernel core” (KC) and a surrounding layer, from which a hierarchy of definitional distances can be derived, all the way out to the periphery of the full dictionary. These definitional distances, too, are correlated with psycholinguistic variables (age of acquisition, concreteness, imageability, oral and written frequency) and hence perhaps with the “mental lexicon” in each of our heads.
DDS-Based Clock Jitter Performance vs . DAC Reconstruction Filter Performance

Rev. 0 Information furnished by Analog Devices is believed to be accurate and reliable. However, no responsibility is assumed by Analog Devices for its use, nor for any infringements of patents or other rights of third parties that may result from its use. Specifications subject to change without notice. No license is granted by implication or otherwise under any patent or patent rights of Analog Devices. Trademarks and registered trademarks are the property of their respective owners. One Technology Way, P.O. Box 9106, Norwood, MA 02062-9106, U.S.A. Tel: 781.329.4700 www.analog.com Fax: 781.461.3113 ©2006 Analog Devices, Inc. All rights reserved. A reconstruction filter is an important element for creating a clean, low jitter clock signal from a direct digital synthesizer (DDS). A reconstruction filter is used at the output of the DAC to attenuate image frequencies. However, a physical filter cannot be implemented with ideal stop band rejection extending out to infinite frequency. This is due to component parasitic effects as well as the physical limitations of printed circuit board layout. Failing to use a reconstruction filter with sufficient stop-band rejection can degrade the performance of the DDS.
A novel cosmetic approach to treat thinning hair.

BACKGROUND
Many of today's treatments associated with 'thinning hair', such as female pattern hair loss and telogen effluvium, are focused on two of the key aspects of the condition. Over-the-counter or prescription medications are often focused on improving scalp hair density while high-quality cosmetic products work to prevent further hair damage and minimize mid-fibre breakage. Fibre diameter is another key contributor to thinning hair, but it is less often the focus of medical or cosmetic treatments.


OBJECTIVES
To examine the ability of a novel leave-on technology combination [caffeine, niacinamide, panthenol, dimethicone and an acrylate polymer (CNPDA)] to affect the diameter and behaviour of individual terminal scalp hair fibres as a new approach to counteract decreasing fibre diameters.


METHODS
Testing methodology included fibre diameter measures via laser scan micrometer, assessment of fibre mechanical and behavioural properties via tensile break stress and torsion pendulum testing, and mechanistic studies including cryoscanning electron microscopy and autoradiographic analysis.


RESULTS
CNPDA significantly increased the diameter of individual, existing terminal scalp hair fibres by 2-5 μm, which yields an increase in the cross-sectional area of approximately 10%. Beyond the diameter increase, the CNPDA-thickened fibres demonstrated the altered mechanical properties characteristic of thicker fibres: increased suppleness/pliability (decreased shear modulus) and better ability to withstand force without breaking (increased break stress).


CONCLUSIONS
Although cosmetic treatments will not reverse the condition, this new approach may help to mitigate the effects of thinning hair.
Academic stress and Internet addiction from general strain theory framework

The goal of this study was to examine the mediating role of negative emotions in the link between academic stress and Internet addiction among Korean adolescents. We attempted to extend the general strain theory to Internet addiction by exploring psychological pathways from academic stress to Internet addiction using a national and longitudinal panel study. A total of 512 adolescents completed self-reported scales for academic stress, negative emotions, and Internet addiction. We found that academic stress was positively associated with negative emotions and Internet addiction, and negative emotions were positively associated with Internet addiction. Further, the results of structural equation modeling revealed that adolescents’ academic stress had indirectly influenced Internet addiction through negative emotions. The results of this study suggest that adolescents who experience academic stress might be at risk for Internet addiction, particularly when accompanied with negative emotions. These findings provided significant implications for counselors and policymakers to prevent adolescents’ Internet addiction, and extended the general strain theory to Internet addiction which is typically applicable to deviant behavior. 2015 Elsevier Ltd. All rights reserved.
Electromyographic monitoring of facial nerve under different levels of neuromuscular blockade during middle ear microsurgery.

BACKGROUND
The evoked electromyography (EMG) is frequently used to identify facial nerve in order to prevent its damage during surgeries. Partial neuromuscular blockade (NMB) has been suggested to favor EMG activity and insure patients' safety. The aim of this study was to determine an adequate level of NMB correspondent to sensible facial nerve identification by evaluating the relationship between facial EMG responses and peripheral NMB levels during the middle ear surgeries.


METHODS
Facial nerve evoked EMG and NMB monitoring were performed simultaneously in 40 patients who underwent tympanoplasty. Facial electromyographic responses were recorded by insertion of needle electrodes into the orbicularis oris and orbicularis oculi muscles after electrical stimulation on facial nerve. The NMB was observed objectively with the hypothenar muscle's twitching after electrical stimulation of ulnar nerve, and the intensity of blockade was adjusted at levels of 0, 25%, 50%, 75%, 90%, and 100% respectively with increased intravenous infusion of Rocuronium (muscle relaxant).


RESULTS
All of the patients had detectable EMG responses at the levels of NMB <or= 50%. Four out of forty patients had no EMG response at the levels of NMB >or= 75%. A significant linear positive correlation was present between stimulation thresholds and NMB levels while a linear negative correlation was present between EMG amplitudes and NMB levels.


CONCLUSIONS
The facial nerve monitoring via facial electromyographic responses can be obtained when an intraoperative partial neuromuscular blockade is induced to provide an adequate immobilization of the patient. The 50% NMB should be considered as the choice of anesthetic management for facial nerve monitoring in otologic microsurgery based on the relationship of correlation.
Dose-response relationship between hand-transmitted vibration and hand-arm vibration syndrome in a tropical environment.

OBJECTIVES
The dose-response relationship for hand-transmitted vibration has been investigated extensively in temperate environments. Since the clinical features of hand-arm vibration syndrome (HAVS) differ between the temperate and tropical environment, we conducted this study to investigate the dose-response relationship of HAVS in a tropical environment.


METHODS
A total of 173 male construction, forestry and automobile manufacturing plant workers in Malaysia were recruited into this study between August 2011 and 2012. The participants were interviewed for history of vibration exposure and HAVS symptoms, followed by hand functions evaluation and vibration measurement. Three types of vibration doses-lifetime vibration dose (LVD), total operating time (TOT) and cumulative exposure index (CEI)-were calculated and its log values were regressed against the symptoms of HAVS. The correlation between each vibration exposure dose and the hand function evaluation results was obtained.


RESULTS
The adjusted prevalence ratio for finger tingling and numbness was 3.34 (95% CI 1.27 to 8.98) for subjects with lnLVD≥20 ln m(2) s(-4) against those <16 ln m(2) s(-4). Similar dose-response pattern was found for CEI but not for TOT. No subject reported white finger. The prevalence of finger coldness did not increase with any of the vibration doses. Vibrotactile perception thresholds correlated moderately with lnLVD and lnCEI.


CONCLUSIONS
The dose-response relationship of HAVS in a tropical environment is valid for finger tingling and numbness. The LVD and CEI are more useful than TOT when evaluating the dose-response pattern of a heterogeneous group of vibratory tools workers.
Concordance rate for Type II diabetes mellitus in monozygotic twins: actuarial analysis

To determine the concordance rate for Type II (non-insulin-dependent) diabetes mellitus in monozygotic twin pairs, initially ascertained discordant for diabetes, we carried out a prospective study on 44 non-diabetic subjects, each of whom had a sibling twin with diabetes (21 men, 23 women, median age 55 years, interquartile range 47–65). The subjects were referred as discordant for Type II diabetes. The twin pairs were part of the British Diabetic Twin Study and ascertained between May 1968 and January 1998. These subjects underwent an OGTT at time of referral and periodically thereafter. The mean follow-up was 8 years (range 0–18 years) and data were collected until January 1996. The percentage of twins who developed Type II diabetes was assessed by standard actuarial life-table methods and the pairwise concordance rate, that is the proportion of concordant pairs over the sum of concordant and discordant pairs, was calculated. The observed rates of concordance for Type II diabetes at 1, 5, 10, and 15 years follow-up were 17, 33, 57, and 76 %, respectively. The concordance rate for any abnormality of glucose metabolism (either Type II diabetes or impaired glucose tolerance) at 15 years follow-up was 96 %. The concordance rate for Type II diabetes in monozygotic twins is very high even in twins initially ascertained discordant for diabetes. [Diabetologia (1999) 42: 146–150]
An Agent-based Optimization Framework for Mobile-Cloud Computing

The proliferation of cloud computing resources in the recent years offers a way for mobile devices with limited resources to achieve computationally intensive tasks in real-time. The mobile-cloud computing paradigm, which involves collaboration between mobile and cloud resources, is expected to become increasingly popular in mobile application development. Dynamic partitioning of applications between mobile and cloud platforms based on resource availability is crucial in achieving the best performance for any computationally intensive mobile application. In this paper, we propose a dynamic performance optimization framework for mobile-cloud computing utilizing mobile agent-based application partitions. The proposed framework imposes minimal infrastructural requirements on the cloud servers, therefore exhibiting widespread applicability, as opposed to previous approaches with stricter requirements. Experiments with two real-world mobile applications serve as an initial feasibility study of the proposed framework and demonstrate the superiority of the proposed approach over monolithic execution of resource-intensive applications on mobile devices.
Effects of faking on self-deception and impression management scales

To investigate the effects of self-presentation on the construct validity of the impression management (IM) and self-deceptive enhancement (SDE) scales of the Balanced Inventory of Social Desirable Responding Version 7 (BIDR-7), 155 participants completed the IM and SDE scales combined with standard instructions. IM and SDE were also presented with three self-presentation instructions: fake good, Agency, and Communion instructions. In addition, selfand social desirability ratings were assessed for a list of 190 personality-trait words. It could be shown that not only IM, but also SDE can be faked if participants are appropriately instructed to do so. In addition, personality-trait words related to IM were rated as socially more desirable than those related to SDE. BIDR scales were more highly related in the faking conditions than in the standard instruction condition. In addition, faked BIDR scores were not related to undistorted BIDR scores. These results implicate that both SDE and IM are susceptible to faking like any other personality questionnaire, and that both SDE and IM loose their original meaning under faking. Therefore, at least under faking social desirability scales do not seem to provide additional diagnostic information beyond that derived from personality scales. 2003 Elsevier Ltd. All rights reserved.
Complex Graphs and Networks

Contents Preface vii Chapter 1. Graph Theory in the Information Age 1 1.1. Introduction 1 1.2. Basic definitions 3 1.3. Degree sequences and the power law 6 1.4. History of the power law 8 1.5. Examples of power law graphs 10 1.6. An outline of the book 17 Chapter 2. Old and New Concentration Inequalities 21 2.1. The binomial distribution and its asymptotic behavior 21 2.2. General Chernoff inequalities 25 2.3. More concentration inequalities 30 2.4. A concentration inequality with a large error estimate 33 2.5. Martingales and Azuma's inequality 35 2.6. General martingale inequalities 38 2.7. Supermartingales and Submartingales 41 2.8. The decision tree and relaxed concentration inequalities 46 Chapter 3. A Generative Model — the Preferential Attachment Scheme 55 3.1. Basic steps of the preferential attachment scheme 55 3.2. Analyzing the preferential attachment model 56 3.3. A useful lemma for rigorous proofs 59 3.4. The peril of heuristics via an example of balls-and-bins 60 3.5. Scale-free networks 62 3.6. The sharp concentration of preferential attachment scheme 64 3.7. Models for directed graphs 70 Chapter 4. Duplication Models for Biological Networks 75 4.1. Biological networks 75 4.2. The duplication model 76 4.3. Expected degrees of a random graph in the duplication model 77 4.4. The convergence of the expected degrees 79 4.5. The generating functions for the expected degrees 83 4.6. Two concentration results for the duplication model 84 4.7. Power law distribution of generalized duplication models 89 Chapter 5. Random Graphs with Given Expected Degrees 91 5.1. The Erd˝ os-Rényi model 91 5.2. The diameter of G n,p 95 iii iv CONTENTS 5.3. A general random graph model 97 5.4. Size, volume and higher order volumes 97 5.5. Basic properties of G(w) 100 5.6. Neighborhood expansion in random graphs 103 5.7. A random power law graph model 107 5.8. Actual versus expected degree sequence 109 Chapter 6. The Rise of the Giant Component 113 6.1. No giant component if w < 1? 114 6.2. Is there a giant component if˜w > 1? 115 6.3. No giant component if˜w < 1? 116 6.4. Existence and uniqueness of the giant component 117 6.5. A lemma on neighborhood growth 126 6.6. The volume of the giant component 129 6.7. Proving the volume estimate of the giant component 131 6.8. Lower bounds for the volume of the giant component 136 6.9. The complement of the giant component and its size 138 6.10. …
The impact of participation in virtual brand communities on consumer trust and loyalty: The case of free software

Purpose – The importance of virtual brand communities is growing day by day as a result of consumers increasingly using online tools to contact fellow consumers in order to get information on which to base their decisions. For this reason, this work aims to explore some of the effects of participation in a virtual brand community on consumer behaviour. Design/methodology/approach – The paper proposes the positive effects of participation in a virtual community on both consumer trust and loyalty to the product, brand or organisation around which the community is developed. In addition, it also proposes a positive effect of trust on consumer loyalty. After the validations of measurement scales, the hypotheses are contrasted through structural modelling. Findings – The data, obtained through a web survey using members of several free software virtual communities, show that participation in the activities carried out in a virtual community may foster consumer trust and loyalty to the mutual interest of the community (the free software in this case). In addition, the study also found a positive and significant effect of consumer trust on loyalty. Research limitations/implications – Data were collected thanks to a web survey using Spanish-speaking subjects. Practical implications – The high costs every company has to face in order to get new customers make it increasingly necessary to reinforce the ties established with customers. In this respect, this study has shown that managers may foster consumer trust and loyalty by developing virtual brand communities and promoting consumers’ participation in them. Originality/value – Most of the works that are focused on virtual communities have been conducted at the conceptual level. Thus, with the aim of moving on this topic, this study analyses empirically the effects of participation in a virtual brand community on consumer behaviour.
FK506 Binding Protein 5 Shapes Stress Responsiveness: Modulation of Neuroendocrine Reactivity and Coping Behavior

BACKGROUND
The Hsp90 cochaperone FK506 binding protein 5 (FKBP5) is an established regulator of the glucocorticoid receptor (GR), and numerous genetic studies have linked it to stress-related diseases such as major depression or posttraumatic stress disorder. However, translational studies including genetic animal models are lacking.


METHODS
Mice deficient of FKBP5 were generated and analyzed in comparison with wildtype littermates. They were subjected to several test paradigms characterizing their emotionality, stress reactivity, and coping behavior as well as hypothalamus-pituitary-adrenal axis function and regulation. Moreover, protein expression of GR and FKBP5 was determined in different brain structures 8 days after stress exposure. The combined dexamethasone/corticotropin-releasing hormone test was performed both in mice and healthy human subjects of different FKBP5 genotypes. The GR function was evaluated by reporter gene assays.


RESULTS
Under basal conditions, deletion of FKBP5 did not change exploratory drive, locomotor activity, anxiety-related behavior, stress-coping, or depression-like behavior. After exposure to different acute stressors of sufficient intensity, however, it led to a more active coping behavior. Moreover, loss of FKBP5 decreased hypothalamus-pituitary-adrenal axis reactivity and GR expression changes in response to stressors. In mice and humans, the FKBP5 genotype also determined the outcome of the dexamethasone/corticotropin-releasing hormone test.


CONCLUSIONS
This study in mice and humans presents FKBP5 as a decisive factor for the physiological stress response, shaping neuroendocrine reactivity as well as coping behavior. This lends strong support to the concept emerging from human studies of FKBP5 as important factor governing gene-environment interactions relevant for the etiology of affective disorders.