LLukas22/scidocs huggingface dataset:
Methylphenidate Normalizes Frontocingulate Underactivation During Error Processing in Attention-Deficit/Hyperactivity Disorder

BACKGROUND
Children with attention-deficit/hyperactivity disorder (ADHD) have deficits in performance monitoring often improved with the indirect catecholamine agonist methylphenidate (MPH). We used functional magnetic resonance imaging to investigate the effects of single-dose MPH on activation of error processing brain areas in medication-naive boys with ADHD during a stop task that elicits 50% error rates.


METHODS
Twelve medication-naive boys with ADHD were scanned twice, under either a single clinical dose of MPH or placebo, in a randomized, double-blind design while they performed an individually adjusted tracking stop task, designed to elicit 50% failures. Brain activation was compared within patients under either drug condition. To test for potential normalization effects of MPH, brain activation in ADHD patients under either drug condition was compared with that of 13 healthy age-matched boys.


RESULTS
During failed inhibition, boys with ADHD under placebo relative to control subjects showed reduced brain activation in performance monitoring areas of dorsomedial and left ventrolateral prefrontal cortices, thalamus, cingulate, and parietal regions. MPH, relative to placebo, upregulated activation in these brain regions within patients and normalized all activation differences between patients and control subjects. During successful inhibition, MPH normalized reduced activation observed in patients under placebo compared with control subjects in parietotemporal and cerebellar regions.


CONCLUSIONS
MPH normalized brain dysfunction in medication-naive ADHD boys relative to control subjects in typical brain areas of performance monitoring, comprising left ventrolateral and dorsomedial frontal and parietal cortices. This could underlie the amelioration of MPH of attention and academic performance in ADHD.
Cancelled elective general surgical operations in Ayub Teaching Hospital.

BACKGROUND
Cancellation of operations in hospitals is a significant problem with far reaching consequences. This study was planned to evaluate reasons for cancellation of elective surgical operation on the day of surgery in Ayub Teaching Hospital, Abbottabad.


METHODS
From July 2006 to June 2007 the medical records of all the patients who had their operations cancelled on the day of surgery in all the three General Surgical units of Ayub Teaching Hospital, Abbottabad were audited prospectively. The number of operation cancelled and reasons for cancellations were documented.


RESULTS
3756 patients were scheduled for surgery during the study period. 2820 (75%) patients were operated upon. 936 (25%) operations were cancelled out of which 338 (36%) were cancelled due to shortage of time, 296 (31.6%) were cancelled due to medical reasons, 152 (16.2%) were cancelled due to shortage of beds while 55 (5.8%) were cancelled due to shortage of anaesthetists. Three operation lists were lost completely. The Anaesthetist cancelled 43%, Surgeon 39% while 18% of operations were cancelled due organizational reasons.


CONCLUSION
Cancellation of patients on operation lists occupy a substantial population (25%) of cases. Majority of cancellation were due to reasons other than patients medical conditions. Better management could have avoided most of these cancellations.
Therapeutic impact of human bone marrow stromal cells expanded by animal serum-free medium for cerebral infarct in rats.

BACKGROUND
The donor cell culture in animal serum-free medium is important for the clinical application of cell transplantation therapy. Recently, human-derived platelet lysate (PL) gained interest as a substitute for fetal calf serum (FCS), but there are no studies that evaluate the validity of human bone marrow stromal cells (hBMSCs) expanded with PL-containing medium for central nervous system disorders.


OBJECTIVE
To test the hypothesis that hBMSCs expanded with FCS-free, PL-containing medium can promote functional recovery after cerebral infarct.


METHODS
hBMSCs were cultured in the FCS- or PL-containing medium. Cell-growth kinetics were analyzed. The vehicle or hBMSCs was stereotactically transplanted into the ipsilateral striatum of the rats subjected to permanent middle cerebral artery occlusion 7 days after the insult. Motor function was assessed for 8 weeks, and the fate of transplanted hBMSCs was examined using immunohistochemistry.


RESULTS
There was no significant difference in hBMSC expansion between the 2 groups. Transplantation of hBMSCs expanded with the FCS- or PL-containing medium equally promoted functional recovery compared with the vehicle group. Histological analysis revealed that there were no significant differences in their migration, survival, and neural differentiation in the infarct brain between the 2 groups.


CONCLUSION
hBMSCs expanded with PL-containing medium retained their capacity of migration, survival, and differentiation and significantly promoted functional recovery when stereotactically transplanted into the infarct brain. The PL may be a clinically valuable and safe substitute for FCS in expanding hBMSCs to regenerate the infarct brain.
Neural Machine Translation

Draft of textbook chapter on neural machine translation. a comprehensive treatment of the topic, ranging from introduction to neural networks, computation graphs, description of the currently dominant attentional sequence-to-sequence model, recent refinements, alternative architectures and challenges. Written as chapter for the textbook Statistical Machine Translation. Used in the JHU Fall 2017 class on machine translation.
Towards a general theory of driver behaviour.

Taylor [Taylor, D.H., 1964. Drivers' galvanic skin response and the risk of accident. Ergonomics 7, 439-451] argued that drivers attempt to maintain a constant level of anxiety when driving which Wilde [Wilde, G.J.S., 1982. The theory of risk homeostasis: implications for safety and health. Risk Anal. 2, 209-225] interpreted to be coupled to subjective estimates of the probability of collision. This theoretical paper argues that what drivers attempt to maintain is a level of task difficulty. Naatanen and Summala [Naatanen, R., Summala, H., 1976. Road User Behaviour and Traffic Accidents. North Holland/Elsevier, Amsterdam, New York] similarly rejected the concept of statistical risk as a determinant of driver behaviour, but in so doing fell back on the learning process to generate a largely automatised selection of appropriate safety margins. However it is argued here that driver behaviour cannot be acquired and executed principally in such S-R terms. The concept of task difficulty is elaborated within the framework of the task-capability interface (TCI) model, which describes the dynamic interaction between the determinants of task demand and driver capability. It is this interaction which produces different levels of task difficulty. Implications of the model are discussed regarding variation in performance, resource allocation, hierarchical decision-making and the interdependence of demand and capability. Task difficulty homeostasis is proposed as a key sub-goal in driving and speed choice is argued to be the primary solution to the problem of keeping task difficulty within selected boundaries. The relationship between task difficulty and mental workload and calibration is clarified. Evidence is cited in support of the TCI model, which clearly distinguishes task difficulty from estimates of statistical risk. However, contrary to expectation, ratings of perceived risk depart from ratings of statistical risk but track difficulty ratings almost perfectly. It now appears that feelings of risk may inform driver decision making, as Taylor originally suggested, but not in terms of risk of collision, but rather in terms of task difficulty. Finally risk homeostasis is presented as a special case of task difficulty homeostasis.
Filicide cases in Turkey, 1995-2000.

AIM
To determine socio-demographic features and criminal liability of individuals who committed filicide in Turkey.


METHOD
The study involved 85 cases of filicide evaluated by the 4th Specialized Board of the Institute of Forensic Medicine in Istanbul in the 1995-2000 period. We assessed the characteristics of parents who committed filicide (age, sex, education level, employment status, and criminal liability) and children victims (age, sex, own or stepchild), as well as the causes of death.


RESULTS
There were 85 parents who committed filicide (41 fathers and 44 mothers) and 96 children victims. The mean age of mothers who committed filicide (52% of filicides) was 26.5-/+7.7 years, and the mean age of fathers (48% of filicides) was 36.1-/+10.0 years (t=-5.00, p<0.001). Individuals diagnosed with psychiatric disturbances, such as schizophrenia (61%), major depression (22%), imbecility (10%), and mild mental retardation (7%), were not subject to criminal liability. Almost half of parents who committed filicide were unemployed and illiterate.


CONCLUSION
Filicide in Turkey was equally committed by mothers and fathers. More than half of the parents were diagnosed with psychiatric disorders and came from disadvantageous socioeconomic environments, where unemployment and illiteracy rates are highly above the average of Turkey.
Promoting Student Engagement by Integrating New Technology into Tertiary Education : The Role of the iPad

Teachers in tertiary education need new strategies to communicate with students of the net generation and to shape enticing educational experiences for them. The use of new approaches such as video-recorded lectures to communicate directly and individually with all students has been the preserve of technology-savvy educators. However, a recent technological advance – the Apple iPad – has the potential to change this situation, offering access to effective and efficient pedagogy in an easy and intuitive way. This paper is a report on the use of the iPad in teaching activities over the past 15 months, showing how it can be used to enhance engagement with learning for tertiary students, both those studying live on campus and those studying at a distance.
Privacy practices of Internet users: Self-reports versus observed behavior

Several recent surveys conclude that people are concerned about privacy and consider it to be an important factor in their online decision making. This paper reports on a study in which (1) user concerns were analysed more deeply and (2) what users said was contrasted with what they did in an experimental e-commerce scenario. Eleven independent variables were shown to affect the online behavior of at least some groups of users. Most significant were trust marks present on web pages and the existence of a privacy policy, though users seldom consulted the policy when one existed. We also find that many users have inaccurate perceptions of their own knowledge about privacy technology and vulnerabilities, and that important user groups, like those similar to the Westin ‘‘privacy fundamentalists’’, do not appear to form a cohesive group for privacy-related decision making. In this study we adopt an experimental economic research paradigm, a method for examining user behavior which challenges the current emphasis on survey data. We discuss these issues and the implications of our results on user interpretation of trust marks and interaction design. Although broad policy implications are beyond the scope of this paper, we conclude by questioning the application of the ethical/legal doctrine of informed consent to online transactions in the light of the evidence that users frequently do not consult privacy policies. r 2005 Elsevier Ltd. All rights reserved.
Whiteheadian Societies and Peirce's Law of Mind: Actuality and Potentiality in the Cosmic Process

AbstractA more suitable philosophical position to counter the claims of scientific materialism re the nature of physical reality can possibly be found in combining the metaphysics of A.N. Whitehead and C.S. Peirce. Peirce postulated a habit-forming tendency or inbuilt potentiality of the cosmic process as a whole to move over time toward ever greater organization and more complex structure. But he is vague on how “the law of the mind” applies to nature below the level of human self-awareness. Whitehead's notion of actual entities (momentary self-constituting subjects of experience) as the “final real things of which the world is made up” logically allows for some primitive form of subjectivity with the requisite potentiality for habit-formation at all levels of existence and activity within nature. In addition, Whitehead's notion of structured societies made up of subsocieties with a “regnant” subsociety seems philosophically to justify the new emphasis on bottom-up rather than top-down causation in the e...
Posterior petrous meningiomas: 82 cases.

OBJECT
The aim of this study was to discuss posterior petrous meningiomas--their classification, clinical manifestations, surgical treatments, and patient outcomes.


METHODS
A retrospective analysis was performed in 82 patients with posterior petrous meningiomas for microsurgery. According to the anatomical relationship with the posterior surface of the petrous bone and with special reference to the internal auditory canal (IAC), posterior petrous meningiomas were classified into three types: Type I, located laterally to the IAC (28 cases); Type II, located medially to the IAC, which might extend to the cavernous sinus and clivus (32 cases); and Type III, extensively attached to the posterior surface of the petrous bone, which might envelop the seventh and eighth cranial nerves (22 cases). Sixty-eight (83%) of 82 cases involved total resection. The rate of anatomical preservation of facial nerve was 97.5%, whereas the functional preservation rate was 81%. The rate of hearing preservation was 67%. All Type I tumors were completely resected, and the rate of anatomical preservation of facial nerve was 100% and functional preservation was 93%. Regarding Type II lesions, 75% of 32 cases involved total resection; the rate of anatomical preservation of facial nerve was 97% and functional preservation was 75%. For Type III lesions, 73% of 22 cases were totally resected. The rate of anatomical preservation of facial nerve in patients with this tumor type was 95%, whereas functional preservation was 73%.


CONCLUSIONS
Clinical manifestations and surgical prognoses are different among the various types of posterior petrous meningiomas. It is more difficult for Types II and III tumors to be resected radically than Type I lesions, and postoperative functional outcomes are significantly worse accordingly. The primary principles in dealing with this disease entity include preservation of vital vascular and central nervous system structures and total resection of the tumor as much as possible.
Visual Analysis of MOOC Forums with iForum

Discussion forums of Massive Open Online Courses (MOOC) provide great opportunities for students to interact with instructional staff as well as other students. Exploration of MOOC forum data can offer valuable insights for these staff to enhance the course and prepare the next release. However, it is challenging due to the large, complicated, and heterogeneous nature of relevant datasets, which contain multiple dynamically interacting objects such as users, posts, and threads, each one including multiple attributes. In this paper, we present a design study for developing an interactive visual analytics system, called iForum, that allows for effectively discovering and understanding temporal patterns in MOOC forums. The design study was conducted with three domain experts in an iterative manner over one year, including a MOOC instructor and two official teaching assistants. iForum offers a set of novel visualization designs for presenting the three interleaving aspects of MOOC forums (i.e., posts, users, and threads) at three different scales. To demonstrate the effectiveness and usefulness of iForum, we describe a case study involving field experts, in which they use iForum to investigate real MOOC forum data for a course on JAVA programming.
Segmentation-free Vehicle License Plate Recognition using ConvNet-RNN

While vehicle license plate recognition (VLPR) is usually done with a sliding window approach, it can have limited performance on datasets with characters that are of variable width. This can be solved by hand-crafting algorithms to prescale the characters. While this approach can work fairly well, the recognizer is only aware of the pixels within each detector window, and fails to account for other contextual information that might be present in other parts of the image. A sliding window approach also requires training data in the form of presegmented characters, which can be more difficult to obtain. In this paper, we propose a unified ConvNet-RNN model to recognize real-world captured license plate photographs. By using a Convolutional Neural Network (ConvNet) to perform feature extraction and using a Recurrent Neural Network (RNN) for sequencing, we address the problem of sliding window approaches being unable to access the context of the entire image by feeding the entire image as input to the ConvNet. This has the added benefit of being able to perform end-to-end training of the entire model on labelled, full license plate images. Experimental results comparing the ConvNet-RNN architecture to a sliding window-based approach shows that the ConvNet-RNN architecture performs significantly better. Keywords—Vehicle license plate recognition, end-to-end recognition, ConvNet-RNN, segmentation-free recognition
Performance tests in people with chronic low back pain: responsiveness and minimal clinically important change.

STUDY DESIGN
Cohort study.


OBJECTIVE
To assess the responsiveness and minimal clinically important change (MCIC) of 6 commonly-used performance tests (5-minute walking, 50-ft walking, sit-to-stand, 1 minute stair climbing, loaded forward reach, Progressive Isoinertial Lifting Evaluation).


SUMMARY OF BACKGROUND DATA
Performance tests are used to evaluate physical function in people with low back pain. Little is known about their clinimetric properties.


METHODS
Performance tests were administered in people with chronic nonspecific low back pain (n = 198) before and after 10 weeks of treatment. At 10 weeks, the global perceived effect scale was used to determine if participants judged themselves as worsened, unchanged, or improved. The mean change scores for each performance test were calculated. A performance test was considered responsive if the area under the receiver operating characteristic curve (AUC) was equal to or greater than 0.70. We used 2 methods to evaluate MCIC: the optimal cut-off point based on the receiver operating characteristic curve, which takes into account both sensitivity and specificity, and the minimal detectable change for improvement, which considers test specificity only.


RESULTS
In general, the mean change scores were the smallest in participants who judged themselves worsened and largest in those reporting to be improved. Sit-to-stand (AUC = 0.75) and stair climbing (AUC = 0.72) were the only performance tests that showed adequate responsiveness. For sit-to-stand, the MCIC ranged from 4.1 to 9.8 seconds (19%-45% of the mean baseline score). For stair climbing, the MCIC ranged from 14.5 to 23.9 steps (19%-31% of the mean baseline score).


CONCLUSION
Only 2 of the 6 performance tests were responsive. Both had acceptable MCIC values. Developing individualized performance tests might partly overcome the general lack of responsiveness of performance tests. Future research should focus on the clinimetric testing of performance tests in subgroups.
Ventilation and perfusion magnetic resonance imaging of the lung

A close interaction between the respiratory pump, pulmonary parenchyma and blood circulation is essential for a normal lung function. Many pulmonary diseases present, especially in their initial phase, a variable regional impairment of ventilation and perfusion. In the last decades various techniques have been established to measure the lung function. Besides the global pulmonary function tests (PFTs) imaging techniques gained increasing importance to detect local variations in lung function, especially for ventilation and perfusion assessment. Imaging modalities allow for a deeper regional insight into pathophysiological processes and enable improved planning of invasive procedures. In contrast to computed tomography (CT) and the nuclear medicine techniques, magnetic resonance imaging (MRI), as a radiation free imaging modality gained increasing importance since the early 1990 for the assessment of pulmonary function. The major inherent problems of lung tissue, namely the low proton density and the pulmonary and cardiac motion, were overcome in the last years by a constant progress in MR technology. Some MR techniques are still under development, a process which is driven by scientific questions regarding the physiology and pathophysiology of pulmonary diseases, as well as by the need for fast and robust clinically applicable imaging techniques as safe therapy monitoring tools. MRI can be considered a promising ionizing-free alternative to techniques like CT or nuclear medicine techniques for the evaluation of lung function. The goal of this article is to provide an overview on selected MRI techniques for the assessment of pulmonary ventilation and perfusion.
Improving the Diagnostic Accuracy of the Distress Thermometer: A Potential Role for the Impact Thermometer.

CONTEXT
Screening for and management of distress in clinical practice is an important issue in the field of psycho-oncology. The Distress Thermometer (DT) is a common screening tool, but other methods recently have been proposed, with the aim of improving its diagnostic accuracy.


OBJECTIVES
To investigate the diagnostic accuracy of the DT alone and combined with the Impact Thermometer (IT), via the use of two possible combination methods.


METHODS
A heterogeneous sample of 385 adult patients with cancer completed the DT, the IT, and the Brief Symptom Inventory-18.


RESULTS
The results of the DT were comparable with those found in previous studies, indicating that the DT was adequate for "screening" but had limited value for "case finding." The DT and the IT combined (summed or paired scores) showed minor differences in accuracy indexes compared with the DT alone.


CONCLUSION
The results of this study suggest that the addition of the IT to the DT failed to improve its accuracy for identifying distress.
Three-Dimensional Swimming

This article describes a self-propelled dolphin robot that aims to create a stable and controllable experimental platform. A viable bioinspired approach to generate diverse instances of dolphin-like swimming online via a center pattern generator (CPG) network is proposed.The characteristic parameters affecting three-dimensional (3-D) swimming performance are further identified and discussed. Both interactive and programmed swimming tests are provided to illustrate the validity of the present scheme.