LLukas22/scidocs huggingface dataset:
Identification and tissue distribution of odorant binding protein genes in the lucerne plant bug Adelphocoris lineolatus (Goeze).

Insect odorant binding proteins (OBPs) are required for insect olfaction perception and play a key role in transporting hydrophobic semiochemicals across the sensillum lymph to the olfactory receptors (Ors). We constructed two high-quality cDNA libraries from the male and female antennae of the lucerne plant bug, Adelphocoris lineolatus (Goeze) (Hemiptera: Miridae), a hemipteran species in a large and economically important phylogenetic group of phytophagous insects. A total of 1538 male ESTs and 1576 female ESTs were sequenced and analyzed, which produced 2915 high-quality ESTs for further analysis. The 2915 ESTs were assembled to 1423 unigenes. Of the 1423 unigenes, 895 (63%) showed no significant similarity with any known GenBank entry. The most prevalent transcripts in the cDNA libraries are OBPs, chemosensory proteins (CSPs), protein takeout precursors, antennae-specific proteins. We identified 14 genes encoding 12 "classical OBPs" with only six conserved cysteines and 2 "Plus-C OBPs" with two additional conserved cysteines and a conserved proline immediately after the sixth cysteine. AlinOBP4 has a very high amino acid identity of 89% to LAP, a well studied OBP of the tarnished plant bug Lygus lineolaris. The expression profiles of the 14 OBPs in different tissues (antennae, heads, thoraxes, abdomens, legs and wings) were measured by real-time qPCR. The results revealed some OBP genes are highly and differentially expressed in male and female antennae, and four OBP genes have an extremely high transcript level in the legs. Of two Plus-C OBP genes, one (AlinOBP14) is highly expressed only in the heads and another (AlinOBP7) is expressed in all olfactory tissues with much lower transcript levels comparing to other OBPs. The possible physiological functions of these OBPs are discussed.
Fitting 3D garment models onto individual human models

Designing an elegant 3D virtual garment model for a 3D virtual human model is labor-intensive, because most existing garment models are custom-made for a specific human model and cannot be easily reused for other individuals. In this paper, we propose a novel method for fitting a given 3D garment model onto human models of various body shapes and poses. The fitting is accomplished by deforming the garment mesh to match the shapes of the human models by using a combination of the following: skeleton-driven volumetric deformation, garment–human shape similarity matching and evaluation, the constraints of garment–human contact, and garment–human ease allowance. Experiments show that our approach performs very well and has the potential to be used in the garment design industry. & 2010 Elsevier Ltd. All rights reserved.
Principal-Teacher Interactions: How Affective Relationships Shape Principal and Teacher Attitudes.

Purpose: Research finds that the attitudes of principals and teachers create an atmosphere for learning, often referred to as school climate, that influences school effectiveness. Other research shows that atmospheres of trust, shared vision, and openness create positive school climate conditions. Little is known, however, about how these climates emerge in some schools and not others. There is good theoretical reason to suspect that interpersonal relationships between principals and their teachers influence school professionals’ attitudes that define the broader school climate. Theories from organizational studies, social psychology, and sociology inform hypotheses about how affective, cathectic responses from interpersonal principal–teacher relationships explain variation in school professionals’ satisfaction, cohesion, and commitment levels. Research Design: Nationally representative data from the Schools and Staffing Survey, 2003–04, match principals to teachers in public elementary schools. Using structural equation modeling, relational mechanisms between principals and their teachers are identified and explain positive principal attitudes. This process is then linearly regressed to explain the effects of these relationships on teachers’ attitudes. Findings: Principals’ relationships with their teachers affect Article at Ebsco Electronic Journals Service (EJS) on June 14, 2012 eaq.sagepub.com Downloaded from 40 Educational Administration Quarterly 48(1) principals’ and teachers’ satisfaction, cohesion, and commitment levels. Among principals, these positive work relationships improve job satisfaction, cohesion perceptions, and commitment levels. Among teachers, substantial variation is explained directly by the relationship mechanism of principals sharing expectations with their teachers. Conclusions: School professionals’ attitudes form under similar organizational conditions as those of other workers. These relationships affect the schooling environment. Because of their centrality and leadership position, particular focus is paid to role of the principal in these relationships. The relationships of principals, as the school leader, strongly and directly affect teachers’ attitudes, which define the schooling climate.
Pharmacodynamics of diazepam co-administered with methadone or buprenorphine under high dose conditions in opioid dependent patients.

BACKGROUND
Benzodiazepine abuse is common among methadone- and buprenorphine-maintained patients; however interactions between these drugs under high dose conditions have not been adequately examined under controlled conditions.


OBJECTIVE
To investigate the effects of co-administering diazepam with methadone or buprenorphine under high dose conditions.


DESIGN
Double-blind, randomly ordered, 2 x 2 cross-over design in which the effects of diazepam dose (0mg versus 40 mg) and opioid dose (100% versus 150% normal dose) were examined over four sessions in methadone- and buprenorphine-maintained patients.


PARTICIPANTS
Four methadone- and seven buprenorphine-prescribed patients without concurrent dependence on other substances or significant medical co-morbidity.


MEASURES
Physiological (pulse rate, blood pressure, pupil size, respiratory rate and peripheral SpO2), subjective (ARCI, VAS ratings) and performance (reaction time, cancellation task and Digit Symbol Substitution Test, DSST) measures were taken prior to and for 6h post-dosing.


RESULTS
High dose diazepam was associated with time-dependent increases in the intensity of subjective drug effects (strength of drug effect, sedation) and decreases in psychological performance (reaction time, DSST) for both methadone and buprenorphine patients. These effects were generally independent of the opioid dose administered. High dose opioid administration (150% normal dose) was associated with reductions in overall SpO2 levels and performance (reaction time, DSST) in the methadone patients, but had virtually no impact on pharmacodynamic responses in the buprenorphine group.


CONCLUSION
High dose diazepam significantly alters subjective drug responses and psychological performance in patients maintained on methadone and buprenorphine.
Redundant Late Domain Functions of Tandem VP2 YPX3L Motifs in Nonlytic Cellular Egress of Quasi-enveloped Hepatitis A Virus.

The quasi-envelopment of hepatitis A virus (HAV) capsids in exosome-like virions (eHAV) is an important but incompletely understood aspect of the hepatovirus life cycle. This process is driven by recruitment of newly assembled capsids to endosomal vesicles into which they bud to form multivesicular bodies with intraluminal vesicles that are later released at the plasma membrane as eHAV. The endosomal sorting complexes required for transport (ESCRT) are key to this process, as is the ESCRT-III-associated protein, ALIX, which also contributes to membrane budding of conventional enveloped viruses. YPX1or3L late domains in the structural proteins of these viruses mediate interactions with ALIX, and two such domains exist in the HAV VP2 capsid protein. Mutational studies of these domains are confounded by the fact that the Tyr residues (important for interactions of YPX1or3L peptides with ALIX) are required for efficient capsid assembly. However, single Leu-to-Ala substitutions within either VP2 YPX3L motif (L1-A and L2-A mutants) were well tolerated, albeit associated with significantly reduced eHAV release. In contrast, simultaneous substitutions in both motifs (L1,2-A) eliminated virus release but did not inhibit assembly of infectious intracellular particles. Immunoprecipitation experiments suggested that the loss of eHAV release was associated with a loss of ALIX recruitment. Collectively, these data indicate that HAV YPX3L motifs function as redundant late domains during quasi-envelopment and viral release. Since these motifs present little solvent-accessible area in the crystal structure of the naked extracellular capsid, the capsid structure may be substantially different during quasi-envelopment.IMPORTANCE Nonlytic release of hepatitis A virus (HAV) as exosome-like quasi-enveloped virions is a unique but incompletely understood aspect of the hepatovirus life cycle. Several lines of evidence indicate that the host protein ALIX is essential for this process. Tandem YPX3L "late domains" in the VP2 capsid protein could be sites of interaction with ALIX, but they are not accessible on the surface of an X-ray model of the extracellular capsid, raising doubts about this putative late domain function. Here, we describe YPX3L domain mutants that assemble capsids normally but fail to bind ALIX and be secreted as quasi-enveloped eHAV. Our data support late domain function for the VP2 YPX3L motifs and raise questions about the structure of the HAV capsid prior to and following quasi-envelopment.
Physical examination tests of the shoulder: a systematic review with meta-analysis of individual tests.

OBJECTIVE
To compile and critique research on the diagnostic accuracy of individual orthopaedic physical examination tests in a manner that would allow clinicians to judge whether these tests are valuable to their practice.


METHODS
A computer-assisted literature search of MEDLINE, CINAHL, and SPORTDiscus databases (1966 to October 2006) using keywords related to diagnostic accuracy of physical examination tests of the shoulder. The Quality Assessment of Diagnostic Accuracy Studies (QUADAS) tool was used to critique the quality of each paper. Meta-analysis through meta-regression of the diagnostic odds ratio (DOR) was performed on the Neer test for impingement, the Hawkins-Kennedy test for impingement, and the Speed test for superior labral pathology.


RESULTS
Forty-five studies were critiqued with only half demonstrating acceptable high quality and only two having adequate sample size. For impingement, the meta-analysis revealed that the pooled sensitivity and specificity for the Neer test was 79% and 53%, respectively, and for the Hawkins-Kennedy test was 79% and 59%, respectively. For superior labral (SLAP) tears, the summary sensitivity and specificity of the Speed test was 32% and 61%, respectively. Regarding orthopaedic special tests (OSTs) where meta-analysis was not possible either due to lack of sufficient studies or heterogeneity between studies, the list that demonstrates both high sensitivity and high specificity is short: hornblowers's sign and the external rotation lag sign for tears of the rotator cuff, biceps load II for superior labral anterior to posterior (SLAP) lesions, and apprehension, relocation and anterior release for anterior instability. Even these tests have been under-studied or are from lower quality studies or both. No tests for impingement or acromioclavicular (AC) joint pathology demonstrated significant diagnostic accuracy.


CONCLUSION
Based on pooled data, the diagnostic accuracy of the Neer test for impingement, the Hawkins-Kennedy test for impingement and the Speed test for labral pathology is limited. There is a great need for large, prospective, well-designed studies that examine the diagnostic accuracy of the numerous physical examination tests of the shoulder. Currently, almost without exception, there is a lack of clarity with regard to whether common OSTs used in clinical examination are useful in differentially diagnosing pathologies of the shoulder.
State-of-the-Art Predictive Maintenance Techniques

Condition-based maintenance techniques for industrial equipment and processes are described in this paper together with examples of their use and discussion of their benefits. These techniques are divided here into three categories. The first category uses signals from existing process sensors, such as resistance temperature detectors (RTDs), thermocouples, or pressure transmitters, to help verify the performance of the sensors and process-to-sensor interfaces and also to identify problems in the process. The second category depends on signals from test sensors (e.g., accelerometers) that are installed on plant equipment (e.g., rotating machinery) in order to measure such parameters as vibration amplitude. The vibration amplitude is then trended to identify the onset of degradation or failure. This second category also includes the use of wireless sensors to provide additional points for collection of data or allow plants to measure multiple parameters to cover not only vibration amplitude but also ambient temperature, pressure, humidity, etc. With each additional parameter that can be measured and correlated with equipment condition, the diagnostic capabilities of the category can increase exponentially. The first and second categories just mentioned are passive, which means that they do not involve any perturbation of the equipment or the process being monitored. In contrast, the third category is active. That is, the third category involves injecting a test signal into the equipment (sensors, cables, etc.) to measure its response and thereby diagnose its performance. For example, the response time of temperature sensors (RTDs and thermocouples) can be measured by the application of the step current signal to the sensor and analysis of the sensor response to the application of the step current. Cable anomalies can be located by a similar procedure referred to as the time domain reflectometry (TDR). This test involves a signal that is sent through the cable to the end device. Its reflection is then recorded and compared to a baseline to identify impedance changes along the cable and thereby identify and locate anomalies. Combined with measurement of cable inductance (L), capacitance (C), and loop resistance (R), or LCR testing, the TDR method can identify and locate anomalies along a cable, identify moisture in a cable or end device, and even reveal gross problems in the cable insulation material. There are also frequency domain reflectometry (FDR) methods, reverse TDR, trending of insulation resistance (IR) measurement, and other techniques which can be used in addition to or instead of TDR and LCR to provide a wide spectrum of tools for cable condition monitoring. The three categories of techniques described in this paper are the subject of current research and development projects conducted by the author and his colleagues at the AMS Corporation with funding from the U.S. Department of Energy (DOE) under the Small Business Innovation Research (SBIR) program.
Work limitations and productivity loss are associated with health-related quality of life but not with clinical severity in patients with psoriasis.

BACKGROUND
According to current guidelines the cost of productivity loss should be considered in pharmacoeconomic analyses. The cost of health-related productivity loss in psoriasis patients is unknown.


OBJECTIVE
To estimate the cost of productivity loss in psoriasis and its association with health-related quality of life and clinical disease severity.


METHODS
Cross-sectional study, recruitment of adult participants through Internet advertisements. 201 (72.3%) out of 278 eligible participants completed the study. Health-related work productivity loss, quality of life and clinical severity of psoriasis were assessed by standardized instruments.


RESULTS
Indirect costs of productivity loss clearly exceed the total direct cost. In contrast to objective clinical disease severity, health-related quality of life (measured by the Dermatology Life Quality Index) is an independent predictor of work productivity.


CONCLUSIONS
There is good reason to believe that intervention can reduce health-related productivity loss by improving patients' quality of life. Savings from increased work productivity might offset comparatively high acquisition costs of biological agents.
Attracting Donations : How Iranian Charity Organizations Promote to Attract Donation?

Non-Profit Organizations (NPO), also called the third sector, are organizations that do not aim to generate revenue and, as the name suggests, profit making is not their goal. However, like any oth ...
Photoplethysmography-based ambulatory heartbeat monitoring embedded into a dedicated bracelet

Ambulatory electrocardiogram (ECG) monitors have been intensely used since half century but are still associated to clinical/ambulatory cumbersome procedures. The question of this research is the following: what is the performance of a photoplethysmography (PPG)- based device located at the wrist in terms of heart rate variability (HRV) monitoring? PPG and ECG signals were recorded simultaneously on 4 subjects. Heart-beat (RR) intervals were estimated from both devices. For PPG signals, a multi-sensors approach based on the detection of local minima of the time-derivative was used to estimate RR time series. For ECG signals, an approach based on adaptive threshold was used (gold standard). The normalized differences observed on time-domain and frequency-domain HRV features were computed. Results based on 1565 minutes of recordings (N=94'000) showed an averaged correlation around 0:9 between the HRV features extracted from the PPG and ECG-based device. In view of these results, it appears that the wrist sensor opens the door towards a new generation of comfortable and easy-to-use cardiac HRV tool especially well adapted for long-term monitoring.
Reliability and Validity of the Korean Version of the Internet Addiction Test among College Students

We developed a Korean translation of the Internet Addiction Test (KIAT), widely used self-report for internet addiction and tested its reliability and validity in a sample of college students. Two hundred seventy-nine college students at a national university completed the KIAT. Internal consistency and two week test-retest reliability were calculated from the data, and principal component factor analysis was conducted. Participants also completed the Internet Addiction Diagnostic Questionnaire (IADQ), the Korea Internet addiction scale (K-scale), and the Patient Health Questionnaire-9 for the criterion validity. Cronbach's alpha of the whole scale was 0.91, and test-retest reliability was also good (r = 0.73). The IADQ, the K-scale, and depressive symptoms were significantly correlated with the KIAT scores, demonstrating concurrent and convergent validity. The factor analysis extracted four factors (Excessive use, Dependence, Withdrawal, and Avoidance of reality) that accounted for 59% of total variance. The KIAT has outstanding internal consistency and high test-retest reliability. Also, the factor structure and validity data show that the KIAT is comparable to the original version. Thus, the KIAT is a psychometrically sound tool for assessing internet addiction in the Korean-speaking population.
Accuracy of an automated blood pressure device in stable inpatients: optimum vs routine use.

BACKGROUND
Despite widespread use of the automated blood pressure (BP) device (IVAC model 4200, IVAC Corporation, San Diego, Calif), there is little formal validation in the literature on its accuracy.


OBJECTIVE
To assess the accuracy of the IVAC 4200 device, both under standardized conditions and as routinely used by ward staff, compared with the true indirect BP measured by mercury manometer (MM).


METHODS
One hundred forty-five stable inpatients were randomly selected for BP measurements by 3 randomly ordered protocols: (1) MM performed by certified investigators, (2) IVAC 4200 BP performed by trained investigators (research automated [RA]), and (3) IVAC 4200 BP performed by ward personnel (ward automated [WA]).


RESULTS
For RA compared with MM ("true" indirect BP), 59% of systolic and 54% of diastolic readings were within 5 mm Hg and 83% of systolic and 86% of diastolic were within 10 mm Hg for a British Hypertension Society grade C for both. For WA compared with MM, 40% of systolic and 50% of diastolic readings were within 5 mm Hg and 70% of systolic and 80% of diastolic readings were within 10 mm Hg for British Hypertension Society grades D and C, respectively. The presence of arrhythmias and/or low K5 values (fifth phase of Korotkoff sounds <30 mm Hg) significantly increased the inaccuracy for diastolic values. Inappropriate cuff selection significantly increased inaccuracy of systolic BP (WA vs MM).


CONCLUSIONS
The IVAC 4200 yields substandard estimates of systolic and diastolic BP even under standardized, thus optimum conditions. The presence of arrhythmias or low K5 values and the selection of inappropriate cuff size by the ward staff also contributed to inaccuracy.
Clinical Correlates and Prognostic Value of Proenkephalin in Acute and Chronic Heart Failure.

BACKGROUND
Proenkephalin (pro-ENK) has emerged as a novel biomarker associated with both renal function and cardiac function. However, its clinical and prognostic value have not been well evaluated in symptomatic patients with heart failure.


METHODS AND RESULTS
The association between pro-ENK and markers of renal function was evaluated in 95 patients with chronic heart failure who underwent renal hemodynamic measurements, including renal blood flow (RBF) and glomerular filtration rate (GFR) with the use of 131I-Hippuran and 125I-iothalamate clearances, respectively. The association between pro-ENK and clinical outcome in acute heart failure was assessed in another 1589 patients. Pro-ENK was strongly correlated with both RBF (P < .001) and GFR (P < .001), but not with renal tubular markers. In the acute heart failure cohort, pro-ENK was a predictor of death through 180 days, heart failure rehospitalization through 60 days, and death or cardiovascular or renal rehospitalization through day 60 in univariable analyses, but its predictive value was lost in a multivariable model when other renal markers were entered in the model.


CONCLUSIONS
In patients with chronic and acute heart failure, pro-ENK is strongly associated with glomerular function, but not with tubular damage. Pro-ENK provides limited prognostic information in patients with acute heart failure on top of established renal markers.
Trends in fatalities from distracted driving in the United States, 1999 to 2008.

OBJECTIVES
We examined trends in distracted driving fatalities and their relation to cell phone use and texting volume.


METHODS
The Fatality Analysis Reporting System (FARS) records data on all road fatalities that occurred on public roads in the United States from 1999 to 2008. We studied trends in distracted driving fatalities, driver and crash characteristics, and trends in cell phone use and texting volume. We used multivariate regression analysis to estimate the relation between state-level distracted driving fatalities and texting volumes.


RESULTS
After declining from 1999 to 2005, fatalities from distracted driving increased 28% after 2005, rising from 4572 fatalities to 5870 in 2008. Crashes increasingly involved male drivers driving alone in collisions with roadside obstructions in urban areas. By use of multivariate analyses, we predicted that increasing texting volumes resulted in more than 16,000 additional road fatalities from 2001 to 2007.


CONCLUSIONS
Distracted driving is a growing public safety hazard. Specifically, the dramatic rise in texting volume since 2005 appeared to be contributing to an alarming rise in distracted driving fatalities. Legislation enacting texting bans should be paired with effective enforcement to deter drivers from using cell phones while driving.