LLukas22/scidocs huggingface dataset:
Provocation of obsessive-compulsive symptoms: a quantitative voxel-based meta-analysis of functional neuroimaging studies.

OBJECTIVE
Recent functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) studies based on the symptom provocation paradigm have explored neural correlates of the cognitive and emotional processes associated with the emergence of obsessive-compulsive disorder (OCD) symptoms. Although most studies showed the involvement of cortico-subcortical loops originating in the orbitofrontal cortex and the anterior cingulate cortex, an increased activity within numerous other regions of the brain has inconsistently been reported across studies. To provide a quantitative estimation of the cerebral activation patterns related to the performance of the symptom provocation task by OCD patients, we conducted a voxel-based meta-analysis.


METHODS
We searched the PubMed and MEDLINE databases for studies that used fMRI and PET and that were based on the symptom provocation paradigm. We entered data into a paradigm-driven activation likelihood estimation meta-analysis.


RESULTS
We found significant likelihoods of activation in cortical and subcortical regions of the orbitofrontal and anterior cingulate loops. The left dorsal frontoparietal network, including the dorsolateral prefrontal cortex and precuneus, and the left superior temporal gyrus also demonstrated significant likelihoods of activation.


CONCLUSION
Consistent results across functional neuroimaging studies suggest that the orbitofrontal and anterior cingulate cortices are involved in the mediation of obsessive-compulsive symptoms. Based on recent literature, we suggest that activations within the dorsal frontoparietal network might be related to patients' efforts to resist the obsessive processes induced by the provocation task. Further research should elucidate the specific neural correlates of the various cognitive and emotional functions altered in OCD.
Polymeric diet alone versus corticosteroids in the treatment of active pediatric Crohn's disease.

Introduction: Nutritional therapy has been reported to have an almost equivalent efficacy to that of corticosteroids in achieving clinical remission in active Crohn’s disease (CD). However, the effects of both treatments on intestinal mucosal inflammation rarely are reported. In a randomized controlled trial in children with active CD, the authors compared the efficacy of nutritional therapy alone with that of corticosteroids on clinical variables and intestinal mucosal healing.
Mixed Gated/Exhaustive Service in a Polling Model with Priorities

In this paper we consider a single-server polling system with switch-over times. We introduce a new service discipline, mixed gated/exhaustive service, that can be used for queues with two types of customers: high and low priority customers. At the beginning of a visit of the server to such a queue, a gate is set behind all customers. High priority customers receive priority in the sense that they are always served before any low priority customers. But high priority customers have a second advantage over low priority customers. Low priority customers are served according to the gated service discipline, i.e. only customers standing in front of the gate are served during this visit. In contrast, high priority customers arriving during the visit period of the queue are allowed to pass the gate and all low priority customers before the gate. We study the cycle time distribution, the waiting time distributions for each customer type, the joint queue length distribution of all priority classes at all queues at polling epochs, and the steadystate marginal queue length distributions for each customer type. Through numerical examples we illustrate that the mixed gated/exhaustive service discipline can significantly decrease waiting times of high priority jobs. In many cases there is a minimal negative impact on the waiting times of low priority customers but, remarkably, it turns out that in polling systems with larger switchover times there can be even a positive impact on the waiting times of low priority customers.
Protocol for the examination of specimens from patients with melanoma of the skin.

Authors David P. Frishberg, MD, FCAP* Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California Charles Balch, MD Departments of Surgery, Oncology, and Dermatology, Johns Hopkins University, Baltimore, Maryland Bonnie L. Balzer, MD, PhD, FCAP Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California A. Neil Crowson, MD, FCAP Regional Medical Laboratory, Departments of Dermatology, Pathology and Surgery, University of Oklahoma, Tulsa, Oklahoma Mukund Didolkar, MD, FACS Division of Surgical Oncology, Sinai Hospital of Baltimore, Department of Surgery, Johns Hopkins University, Baltimore, Maryland Alexander Lazar, MD, PhD, FCAP Department of Pathology and Dermatology, The University of Texas MD Anderson Cancer Center, Houston, Texas Jennifer M. McNiff, MD, FASCP Departments of Dermatology and Pathology, Yale University School of Medicine Roger R Perry, MD, FACS Department of Surgery, Eastern Virginia Medical School, Norfolk, Virginia Victor G. Prieto, MD, PhD, FCAP Departments of Pathology and Dermatology, The University of Texas MD Anderson Cancer Center, Houston, Texas Priya Rao, MD, FCAP Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas M. Timothy Smith, MD Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina Bruce Robert Smoller, MD, FCAP Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas Mark R. Wick, MD, FCAP Department of Pathology, University of Virginia Health System, Charlottesville, Virginia For the Members of the Cancer Committee, College of American Pathologists
Absence of a chromatic linear motion mechanism in human vision

We have investigated motion mechanisms in central and perifoveal vision using two-frame random Gabor kinematograms with isoluminant red-green or luminance stimuli. In keeping with previous results, we find that performance dominated by a linear motion mechanism is obtained using high densities of micropatterns and small temporal intervals between frames, while nonlinear performance is found with low densities and longer temporal intervals [Boulton, J. C., & Baker, C. L. (1994) Proceedings of SPIE, computational vision based on neurobiology, 2054, 124-133]. We compare direction discrimination and detection thresholds in the presence of variable luminance and chromatic noise. Our results show that the linear motion response obtained from chromatic stimuli is selectively masked by luminance noise; the effect is selective for motion since luminance noise masks direction discrimination thresholds but not stimulus detection. Furthermore, we find that chromatic noise has the reverse effect to luminance noise: detection thresholds for the linear chromatic stimulus are masked by chromatic noise but direction discrimination is relatively unaffected. We thus reveal a linear 'chromatic' mechanism that is susceptible to luminance noise but relatively unaffected by color noise. The nonlinear chromatic mechanism behaves differently since both detection and direction discrimination are unaffected by luminance noise but masked by chromatic noise. The double dissociation between the effects of chromatic and luminance noise on linear and nonlinear motion mechanisms is not based on stimulus speed or differences in the temporal presentations of the stimuli. We conclude that: (1) 'chromatic' linear motion is solely based on a luminance signal, probably arising from cone-based temporal phase shifts; (2) the nonlinear chromatic motion mechanism is purely chromatic; and (3) we find the same results for both perifoveal and foveal presentations.
HAZUS-MH Flood Loss Estimation Methodology . II . Damage and Loss Assessment

Part I of this two-part paper provided an overview of the HAZUS-MH Flood Model and a discussion of its capabilities for characterizing riverine and coastal flooding. Included was a discussion of the Flood Information Tool, which permits rapid analysis of a wide variety of stream discharge data and topographic mapping to determine flood-frequencies over entire floodplains. This paper reports on the damage and loss estimation capability of the Flood Model, which includes a library of more than 900 damage curves for use in estimating damage to various types of buildings and infrastructure. Based on estimated property damage, the model estimates shelter needs and direct and indirect economic losses arising from floods. Analyses for the effects of flood warning, the benefits of levees, structural elevation, and flood mapping restudies are also facilitated with the Flood Model. DOI: 10.1061/ ASCE 1527-6988 2006 7:2 72 CE Database subject headings: Floods; Damage; Estimation; Models; Mapping.
Technological Developments in Batteries: A Survey of Principal Roles, Types, and Management Needs

Battery energy storage effectively staBIlizes the electric grid and aids renewable integration by balancing supply and demand in real time. The importance of such storage is especially crucial in densely populated urban areas, where traditional storage techniques such as pumped hydroelectric energy storage and compressed-air energy storage are often not feasible.
American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee.

OBJECTIVE
To update the American College of Rheumatology (ACR) 2000 recommendations for hip and knee osteoarthritis (OA) and develop new recommendations for hand OA.


METHODS
A list of pharmacologic and nonpharmacologic modalities commonly used to manage knee, hip, and hand OA as well as clinical scenarios representing patients with symptomatic hand, hip, and knee OA were generated. Systematic evidence-based literature reviews were conducted by a working group at the Institute of Population Health, University of Ottawa, and updated by ACR staff to include additions to bibliographic databases through December 31, 2010. The Grading of Recommendations Assessment, Development and Evaluation approach, a formal process to rate scientific evidence and to develop recommendations that are as evidence based as possible, was used by a Technical Expert Panel comprised of various stakeholders to formulate the recommendations for the use of nonpharmacologic and pharmacologic modalities for OA of the hand, hip, and knee.


RESULTS
Both “strong” and “conditional” recommendations were made for OA management. Modalities conditionally recommended for the management of hand OA include instruction in joint protection techniques, provision of assistive devices, use of thermal modalities and trapeziometacarpal joint splints, and use of oral and topical nonsteroidal antiinflammatory drugs (NSAIDs), tramadol, and topical capsaicin. Nonpharmacologic modalities strongly recommended for the management of knee OA were aerobic, aquatic, and/or resistance exercises as well as weight loss for overweight patients. Nonpharmacologic modalities conditionally recommended for knee OA included medial wedge insoles for valgus knee OA, subtalar strapped lateral insoles for varus knee OA, medially directed patellar taping, manual therapy, walking aids, thermal agents, tai chi, self management programs, and psychosocial interventions. Pharmacologic modalities conditionally recommended for the initial management of patients with knee OA included acetaminophen, oral and topical NSAIDs, tramadol, and intraarticular corticosteroid injections; intraarticular hyaluronate injections, duloxetine, and opioids were conditionally recommended in patients who had an inadequate response to initial therapy. Opioid analgesics were strongly recommended in patients who were either not willing to undergo or had contraindications for total joint arthroplasty after having failed medical therapy. Recommendations for hip OA were similar to those for the management of knee OA.


CONCLUSION
These recommendations are based on the consensus judgment of clinical experts from a wide range of disciplines, informed by available evidence, balancing the benefits and harms of both nonpharmacologic and pharmacologic modalities, and incorporating their preferences and values. It is hoped that these recommendations will be utilized by health care providers involved in the management of patients with OA.
ContikiSec: A Secure Network Layer for Wireless Sensor Networks under the Contiki Operating System

In this paper we introduce ContikiSec, a secure network layer for wireless sensor networks, designed for the Contiki Operating System. ContikiSec has a configurable design, providing three security modes st arting from confidentiality and integrity, and expanding to confidentiality, authentication, and integrity. ContikiSec has been designed to balanc e low energy consumption and security while conforming to a small memory footprint. Our design was based on performance evaluation of existing se curity primitives and is part of the contribution of this paper. Our evaluat ion was performed in the Modular Sensor Board hardware platform for wireles s s nsor networks, running Contiki. Contiki is an open source, highly portable operat ing system for wireless sensor networks (WSN) that is widely us ed in WSNs.
Integrating collocated auxiliary parameters in geostatistical simulations using joint probability distributions and probability aggregation: COSIMULATIONS BY JOINT PDF AND PROBABILITY

[1] We propose a new cosimulation algorithm for simulating a primary attribute using one or several secondary attributes known exhaustively on the domain. This problem is frequently encountered in surface and groundwater hydrology when a variable of interest is measured only at a discrete number of locations and when the secondary variable is mapped by indirect techniques such as geophysics or remote sensing. In the proposed approach, the correlation between the two variables is modeled by a joint probability distribution function. A technique to construct such relation using underlying variables and physical laws is proposed when field data are insufficient. The simulation algorithm proceeds sequentially. At each location of the domain, two conditional probability distribution functions (cpdf) are inferred. The cpdf of the main attribute is inferred in a classical way from the neighboring data and a model of spatial variability. The second cpdf is inferred directly from the joint probability distribution function of the two attributes and the value of the secondary attribute at the location to be simulated. The two distribution functions are combined by probability aggregation to obtain the local cpdf from which a value for the primary attribute is randomly drawn. Various examples using synthetic and remote sensing data demonstrate that the method is more accurate than the classical collocated cosimulation technique when a complex relation relates the two attributes.
The evolving contributions in international strategic management research

In this study, I systematically investigate the evolving contributions and gaps that exist in the international strategic management (ISM) literature. The research I present here reviews leading international business and strategic management journals from 1991 through 2000. The research investigates the topics that have been examined in ISM research, theoretical perspectives employed, outlets for publication, and the breadth of contributions to ISM research. The article also highlights areas in the literature that may provide promising avenues for future research. D 2003 Elsevier Science Inc. All rights reserved.
Incremental value of biomarkers to clinical variables for mortality prediction in acutely decompensated heart failure: the Multinational Observational Cohort on Acute Heart Failure (MOCA) study.

AIM
This study aims to evaluate the incremental value of plasma biomarkers to traditional clinical variables for risk stratification of 30-day and one-year mortality in acutely decompensated heart failure (ADHF).


METHODS AND RESULTS
Through an international collaborative network, individual patient data on 5306 patients hospitalized for ADHF were collected. The all-cause mortality rate was 11.7% at 30 days and 32.9% at one year. The clinical prediction model (age, gender, blood pressure on admission, estimated glomerular filtration rate <60 mL/min/1.73 m(2), sodium and hemoglobin levels, and heart rate) had a c-statistic of 0.74 for 30-day mortality and 0.73 for one-year mortality. Several biomarkers measured at presentation improved risk stratification when added to the clinical model. At 30 days, the net reclassification improvement (NRI) was 28.7% for mid-regional adrenomedullin (MR-proADM; p<0.001) and 25.5% for soluble (s)ST2 (p<0.001). At one year, sST2 (NRI 10.3%), MR-proADM (NRI 9.1%), amino-terminal pro-B-type natriuretic peptide (NT-proBNP; NRI 9.1%), mid-regional proatrial natriuretic peptide (MR-proANP; NRI 7.4%), B-type natriuretic peptide (NRI 5.5%) and C-reactive protein (CRP; NRI 5.3%) reclassified patients with ADHF (p<0.05 for all). CRP also markedly improved risk stratification of patients with ADHF as a dual biomarker combination with MR-proADM (NRI 36.8% [p<0.001] for death at 30 days) or with sST2 (NRI 20.3%; [p<0.001] for one-year mortality).


CONCLUSION
In this study, biomarkers provided incremental value for risk stratification of ADHF patients. Biomarkers such as sST2, MR-proADM, natriuretic peptides and CRP, reflecting different pathophysiologic pathways, add prognostic value to clinical risk factors for predicting both short-term and one-year mortality in ADHF.
Comparison of numerical and verbal rating scales to measure pain exacerbations in patients with chronic cancer pain

BACKGROUND
Numerical rating scales (NRS), and verbal rating scales (VRS) showed to be reliable and valid tools for subjective cancer pain measurement, but no one of them consistently proved to be superior to the other. Aim of the present study is to compare NRS and VRS performance in assessing breakthrough or episodic pain (BP-EP) exacerbations.


METHODS
In a cross sectional multicentre study carried out on a sample of 240 advanced cancer patients with pain, background pain and BP-EP intensity in the last 24 hours were measured using both a 6-point VRS and a 0-10 NRS. In order to evaluate the reproducibility of the two scales, a subsample of 60 patients was randomly selected and the questionnaire was administered for a second time three to four hours later. The proportion of "inconsistent" (background pain intensity higher than or equal to peak pain intensity) evaluations was calculated to compare the two scales capability in discriminating between background and peak pain intensity and Cohen's K was calculated to compare their reproducibility.


RESULTS
NRS revealed higher discriminatory capability than VRS in distinguishing between background and peak pain intensity with a lower proportion of patients giving inconsistent evaluations (14% vs. 25%). NRS also showed higher reproducibility when measuring pain exacerbations (Cohen's K of 0.86 for NRS vs. 0.53 for VRS) while the reproducibility of the two scales in evaluating background pain was similar (Cohen's K of 0.80 vs. 0.77).


CONCLUSIONS
Our results suggest that, in the measurement of cancer pain exacerbations, patients use NRS more appropriately than VRS and as such NRS should be preferred to VRS in this patient's population.
A 10-mm MR-Conditional Unidirectional Pneumatic Stepper Motor

Magnetic resonance (MR) conditional robotic devices facilitate accurate interventional procedures under MR imaging (MRI) guidance. For this purpose, a compact (10-mm diameter) MR-conditional stepper motor is presented. The device features seven key components, which contribute to a dense and easy to fabricate design. Alternating bursts of pressurized air and vacuum can drive the motor in 60° per step to achieve a maximum torque of 2.4 mNm. The relationship between torque and angular speed was investigated to demonstrate motor performance under different loading conditions. The stepper motor was tested in a GE 3T MRI scanner to verify its MR-compatibility. A maximum artifact width of 3 mm was measured in MRI images and a maximum signal-to-noise ratio reduction of 2.49% was recorded.
Theoretical frameworks and instruments for evaluation of critical thinking in nursing and education.

OBJECTIVE
To identify theoretical frameworks and instruments for the evaluation of critical thinking to base studies in nursing and education.


METHOD
Integrative review, with a selection of scientific articles in Portuguese, English and Spanish, in the LILACS, SCIELO, IBECS, MEDLINE/PubMed and SCOPUS databases, using the descriptors "thought", "teaching" and "nursing" in Portuguese and English. The search resulted in 3,147 articles, and 23 papers published between 2010 and 2015 were selected.


RESULTS
Fourteen (60.2%) studies used the Facione framework and eight (34.4%) resorted to different critical thinking assessment tools applied in nursing and education.


CONCLUSIONS
Most studies used the Facione framework. Among the evaluation tools, the California Critical Thinking Skills Test (CCTST) and the Watson-Glaser Critical Thinking Appraisal stood out as the most common instruments; both focus on cognitive skills in critical thinking.
Eighty-one percent event-free survival in advanced Burkitt's lymphoma/leukemia: no differences in outcome between pediatric and adult patients treated with the same intensive pediatric protocol.

BACKGROUND
Advanced Burkitt's lymphoma (BL) has an extremely poor prognosis in adults. With a previous protocol including CNS prophylaxis, 40% of our adult patients achieved CR and only 13% became long survivors. In 1988, following this poor experience, we adopted a very intensive pediatric-derived protocol.


PATIENTS AND METHODS
Twenty-one consecutive patients, 8 adults (median age 35, stage III: 1; IV: 7; leukemias: 6) and 13 children (median age 10, state III: 8; IV: 5; leukemias: 4) were treated with the same protocol (POG 8617), based on alternate two-phase cycles with sequential high-dose CTX, VCR, ADM + CNS chemoprophylaxis (phase A) and HD MTX + HiDAC (phase B). Adults received 6 cycles, children 8; i.t. prophylaxis in phase B was omitted in adults.


RESULTS
Twenty of 21 (95%) patients achieved CR (adults 100%, children 92%). Two patients died early; 2 relapsed at 4 and 9 months. With a median follow-up of 28 months (4-96), 17 patients (81%) are event free (adults 75%, children 85%). Severe infections affected 62% of adults and 15% of children.


CONCLUSIONS
(1) The prognosis of adult advanced BL definitely improved with this intensive protocol. (2) There were no differences in outcome between adults and children. (3) Outcome of lymphoma and leukemia was similar. (4) Severe infections occurred frequently in adults. This intensive pediatric protocol requires a careful supportive therapy.