LLukas22/scidocs huggingface dataset:
ICT in changes of learning theories

Learning theories have been developed over the past 150 years. Some theories developed as a negative reaction to earlier ones. The others learning theories built foundational theories, looking a specific context for learning, or taking them to more sophisticated level. Positive features from many theories influence teaching/learning process in schools to this day. From the point of view information and communication technology there were four learning theories that have been often utilized in the creation of instructional environments: behaviourism, cognitivism, constructivism, and connectivism as learning theory for the digital age. Connectivism was introduced as a theory of learning based on the premise that knowledge exists in the world rather than in the head of an individual. Paper will discuss impact technology on relations to learning theories behaviourism, cognitivism, constructivism, and connectivism in school practice with research results of science teachers. The last part of paper gives example of using ICT in the inquiry-based education in science subjects.
Teamwork and patient safety in dynamic domains of healthcare: a review of the literature.

AIMS/BACKGROUND
This review examines current research on teamwork in highly dynamic domains of healthcare such as operating rooms, intensive care, emergency medicine, or trauma and resuscitation teams with a focus on aspects relevant to the quality and safety of patient care.


RESULTS
Evidence from three main areas of research supports the relationship between teamwork and patient safety: (1) Studies investigating the factors contributing to critical incidents and adverse events have shown that teamwork plays an important role in the causation and prevention of adverse events. (2) Research focusing on healthcare providers' perceptions of teamwork demonstrated that (a) staff's perceptions of teamwork and attitudes toward safety-relevant team behavior were related to the quality and safety of patient care and (b) perceptions of teamwork and leadership style are associated with staff well-being, which may impact clinician' ability to provide safe patient care. (3) Observational studies on teamwork behaviors related to high clinical performance have identified patterns of communication, coordination, and leadership that support effective teamwork.


CONCLUSION
In recent years, research using diverse methodological approaches has led to significant progress in team research in healthcare. The challenge for future research is to further develop and validate instruments for team performance assessment and to develop sound theoretical models of team performance in dynamic medical domains integrating evidence from all three areas of team research identified in this review. This will help to improve team training efforts and aid the design of clinical work systems supporting effective teamwork and safe patient care.
Hepatoid adenocarcinoma of the stomach is a special and easily misdiagnosed or missed diagnosed subtype of gastric cancer with poor prognosis but curative for patients of pN0/1: the experience of a single center.

AIM
To document the clinicopathological characteristics and analyze the possible reasons for misdiagnosis or missed diagnosis of hepatoid adenocarcinoma of the stomach (HAS), using data from a single center.


METHODS
We retrospectively analyzed 19 patients initially diagnosed as HAS and 7 patients initially diagnosed as common gastric cancer with high levels of serum α-fetoprotein (AFP). All had undergone surgical treatment, except 3 patients only had biopsies at our hospital. Immunohistochemistry for AFP and Hepatocyte antigen was performed. Final diagnosis for these 26 patients were made after HE and immunohistochemistry slides reviewed by 2 experienced pathologists. Prognostic factors were determined by univariate analysis.


RESULTS
Nineteen cases were confirmed to be HAS. A total of 4 out of 19 cases initially diagnosed as HAS and 4 out of 7 cases initially diagnosed as common gastric adenocarcinoma were misdiagnosed/missed diagnosed, thus, the misdiagnosis/missed diagnosis rate was 30.8% (8/26). The incidence of HAS among gastric cancer in our center was 0.19% (19/9915). Sixteen (84.2%) patients showed T stages greater than T2, 12 (70.6%) patients had positive lymph nodes in 17 available patients and 3 (15.8%) of the patients with tumors presented liver metastasis at the time of diagnosis. Histologically, cytoplasmic staining types included 10 cases of eosinophilic, 1 case of clear, 5 cases of clear mixed with eosinophilic and 3 cases of basophilic. Fourteen (73.7%) patients expressed AFP, whereas only 6 (31.6%) were hepatocyte-positive. Univariate analysis showed that N stage (HR 2.429, P=0.007) and tumor AFP expression (HR 0.428, P=0.036) were significantly associated with disease-free survival. The median overall survival time was 12.0 months, and the median disease-free survival time was 7.0 months. Four (80%) of 5 N0 patients and 2 (50%) of 4 N1 patients survived without progression, but no N2-3 patients survived.


CONCLUSION
HAS remains easily being misdiagnosed/missed diagnosed based on a pathological examination, probably because the condition is rare and has various cytoplasmic types. Although the survival rate for HAS is poor, a curative effect may be achieved for N0 or N1 cases.
Strategies for Sustainable Urban Development and Urban-Rural Linkages

An important driving force behind urban expansion is the growth of the urban population. But for Europe, this is not a sufficient explanation. The major trend is that European cities have become much less compact. Since the mid-1950s European cities have expanded on average by 78%, whereas the population has grown by only 33%. In the PLUREL project an integrated project within the EU’s 6th Research Framework Programme more than 100 researchers from 15 countries analysed the impacts of urban land consumption at a pan-European level and, through six European and one Chinese case studies, identified how land use conflicts and the pressure towards periurban areas can be strategically managed in different development and regulatory contexts. To summarise, the following strategies were identified as important steps towards more sustainable urban-rural futures: (i) better coordination of transport, land use and open space planning; (ii) urban containment and densification – development of a green compact city; (iii) preservation of blue and green infrastructure; and (iv) preservation of agricultural land and the promotion of local production. The need also remains to strengthen governance at the regional level while at the pan-European level there is clearly a need for more policy attention to be given to urban-rural linkages.
Nivolumab Monotherapy for First-Line Treatment of Advanced Non-Small-Cell Lung Cancer.

PURPOSE
Nivolumab, a programmed death-1 (PD-1) immune checkpoint inhibitor antibody, has demonstrated improved survival over docetaxel in previously treated advanced non-small-cell lung cancer (NSCLC). First-line monotherapy with nivolumab for advanced NSCLC was evaluated in the phase I, multicohort, Checkmate 012 trial.


METHODS
Fifty-two patients received nivolumab 3 mg/kg intravenously every 2 weeks until progression or unacceptable toxicity; postprogression treatment was permitted per protocol. The primary objective was to assess safety; secondary objectives included objective response rate (ORR) and 24-week progression-free survival (PFS) rate; overall survival (OS) was an exploratory end point.


RESULTS
Any-grade treatment-related adverse events (AEs) occurred in 71% of patients, most commonly: fatigue (29%), rash (19%), nausea (14%), diarrhea (12%), pruritus (12%), and arthralgia (10%). Ten patients (19%) reported grade 3 to 4 treatment-related AEs; grade 3 rash was the only grade 3 to 4 event occurring in more than one patient (n = 2; 4%). Six patients (12%) discontinued because of a treatment-related AE. The confirmed ORR was 23% (12 of 52), including four ongoing complete responses. Nine of 12 responses (75%) occurred by first tumor assessment (week 11); eight (67%) were ongoing (range, 5.3+ to 25.8+ months) at the time of data lock. ORR was 28% (nine of 32) in patients with any degree of tumor PD-ligand 1 expression and 14% (two of 14) in patients with no PD-ligand 1 expression. Median PFS was 3.6 months, and the 24-week PFS rate was 41% (95% CI, 27 to 54). Median OS was 19.4 months, and the 1-year and 18-month OS rates were 73% (95% CI, 59 to 83) and 57% (95% CI, 42 to 70), respectively.


CONCLUSION
First-line nivolumab monotherapy demonstrated a tolerable safety profile and durable responses in first-line advanced NSCLC.
Recognizing Primes in Random Polynomial Time

This paper is the first in a sequence of papers which will prove the existence of a random polynomial time algorithm for the set of primes. The techniques used are from arithmetic algebraic geometry and to a lesser extent algebraic and analytic number theory. The result complements the well known result of Strassen and Soloway that there exists a random polynomial time algorithm for the set of composites.
Architectural Tactics for Big Data Cybersecurity Analytic Systems: A Review

Context: Big Data Cybersecurity Analytics is increasingly becoming an important area of research and practice aimed at protecting networks, computers, and data from unauthorized access by analysing security event data using big data tools and technologies. Whilst a plethora of Big Data Cybersecurity Analytic Systems have been reported in the literature, there is a lack of a systematic and comprehensive review of the literature from an architectural perspective. Objective: This paper reports a systematic review aimed at identifying the most frequently reported quality attributes and architectural tactics for Big Data Cybersecurity Analytic Systems. Method: We used Systematic Literature Review (SLR) method for reviewing 74 primary studies selected using well-defined criteria. Results: Our findings are twofold: (i) identification of 12 most frequently reported quality attributes and the justification for their significance for Big Data Cybersecurity Analytic Systems; and (ii) identification and codification of 17 architectural tactics for addressing the quality attributes that are commonly associated with Big Data Cybersecurity Analytic systems. The identified tactics include six performance tactics, four accuracy tactics, two scalability tactics, three reliability tactics, and one security and usability tactic each. Conclusion: Our findings have revealed that (a) despite the significance of interoperability, modifiability, adaptability, generality, stealthiness, and privacy assurance, these quality attributes lack explicit architectural support in the literature (b) empirical investigation is required to evaluate the impact of codified architectural tactics (c) a good deal of research effort should be invested to explore the trade-offs and dependencies among the identified tactics (d) there is a general lack of effective collaboration between academia and industry for supporting the field of Big Data Cybersecurity Analytic Systems and (e) more research is required on the comparative analysis among big data processing frameworks (i.e., Hadoop, Spark, and Storm) when used for Big Data Cybersecurity Analytic Systems.
CSF hypocretin/orexin levels in narcolepsy and other neurological conditions.

OBJECTIVE
To examine the specificity of low CSF hypocretin-1 levels in narcolepsy and explore the potential role of hypocretins in other neurologic disorders.


METHODS
A method to measure hypocretin-1 in 100 microL of crude CSF sample was established and validated. CSF hypocretin-1 was measured in 42 narcolepsy patients (ages 16-70 years), 48 healthy controls (ages 22-77 years,) and 235 patients with various other neurologic conditions (ages 0-85 years).


RESULTS
As previously reported, CSF hypocretin-1 levels were undetectably low (<100 pg/mL) in 37 of 42 narcolepsy subjects. Hypocretin-1 levels were detectable in all controls (224-653 pg/mL) and all neurologic patients (117-720 pg/mL), with the exception of three patients with Guillain-Barré syndrome (GBS). Hypocretin-1 was within the control range in most neurologic patients tested, including patients with AD, PD, and MS. Low but detectable levels (100-194 pg/mL) were found in a subset of patients with acute lymphocytic leukemia, intracranial tumors, craniocerebral trauma, CNS infections, and GBS.


CONCLUSIONS
Undetectable CSF hypocretin-1 levels are highly specific to narcolepsy and rare cases of GBS. Measuring hypocretin-1 levels in the CSF of patients suspected of narcolepsy is a useful diagnostic procedure. Low hypocretin levels are also observed in a large range of neurologic conditions, most strikingly in subjects with head trauma. These alterations may reflect focal lesions in the hypothalamus, destruction of the blood brain barrier, or transient or chronic hypofunction of the hypothalamus. Future research in this area is needed to establish functional significance.
Prediction of the clinical course of chronic obstructive pulmonary disease, using the new GOLD classification: a study of the general population.

RATIONALE
The new Global Initiative for Obstructive Lung Disease (GOLD) stratification of chronic obstructive pulmonary disease (COPD) into categories A, B, C, and D is based on symptoms, level of lung function, and history of exacerbations.


OBJECTIVES
To investigate the abilities of this stratification to predict the clinical course of COPD.


METHODS
Two similar population studies were performed in an area of Copenhagen including 6,628 individuals with COPD.


MEASUREMENTS AND MAIN RESULTS
The patients were monitored for an average period of 4.3 years regarding COPD exacerbations, hospital admissions, and mortality. The percentages of individuals experiencing a COPD exacerbation during the first year of observation were 2.2% in group A, 5.8% in group B, 25.1% in group C, and 28.6% in group D. One- and 3-year mortality rates were 0.6 and 3.8%, respectively, in group A, 3.0 and 10.6% in group B, 0.7 and 8.2% in group C, and 3.4 and 20.1% in group D. Groups B and D, characterized by a higher degree of dyspnea than groups A and C, had five to eight times higher mortality from cardiovascular disease and cancer than did groups A and C.


CONCLUSIONS
The new stratification performs well by identifying individuals at risk of exacerbations. Surprisingly, subgroup B, characterized by more severe dyspnea, had significantly poorer survival than group C, in spite of a higher FEV(1) level. This subgroup warrants special attention, as the poor prognosis could be caused by cardiovascular disease or cancer, requiring additional assessment and treatment.
Development, reliability, and validity of the Handwriting Proficiency Screening Questionnaire (HPSQ).

OBJECTIVE
This study was used to (1) develop an occupational therapy screening questionnaire (the Handwriting Proficiency Screening Questionnaire [HPSQ]) to identify handwriting difficulties among school-aged children and (2) examine its reliability and validity.


METHOD
The questionnaire's content validity was established. Internal consistency, interrater and test-retest reliability, and concurrent and construct validity were initiated. Participants included 7- to 14-year-old (N = 230) typically developing school-aged children.


RESULTS
The tool demonstrated good internal consistency (alpha = .90). Test-retest reliability for the score revealed an intraclass correlation coefficient (ICC) of .84 and interrater reliability of ICC = .92 for the total questionnaire score. Construct and concurrent validity were also confirmed.


CONCLUSION
The HPSQ is suitable for use by occupational therapists for identification of handwriting deficiency among school-aged children and is appropriate for varied academic and clinical uses. More studies with larger samples of varied age groups are required to further support the questionnaire's reliability and validity.
Alignment of the medial tibial plateau affects the rate of joint space narrowing in the osteoarthritic knee.

OBJECTIVE
To determine, in serial fixed-flexion (FF) radiographs of subjects with knee osteoarthritis (KOA), the importance of, and basis for, the effect of alignment of the medial tibial plateau (MTP), as determined by the inter-margin distance (IMD), on joint space narrowing (JSN).


METHODS
Baseline and 12-month X-rays of 590 knees with Kellgren and Lawrence grade (KLG) 2/3 OA from the public-release dataset of the Osteoarthritis Initiative (OAI) were assigned to subgroups based upon IMD at baseline (IMD(BL)) and the difference between IMD(BL) and IMD(12 mos). Relationships of JSN to IMD(BL) and to the difference between IMD(BL and) IMD(12 mos) were evaluated.


RESULTS
In all 590 knees, mean JSN was 0.13 ± 0.51 mm (P<0.0001) and MTP alignment and replication of IMD(BL) in the 12-month film were, in general, poor. JSN was significantly (P=0.012) more rapid in Subgroup A (IMD≤1.70 mm at both time points) than in Subgroup B (both IMDs>1.70 mm): 0.15 ± 0.43; 0.08 ± 0.47. Within Subgroup B we identified a subset, Subgroup B1, in which, although alignment was poor at both time points, the large IMD(BL) was, by chance, highly reproduced by IMD(12 mos) (difference between the two IMDs=0.01 ± 0.27 mm, NS). JSN in Subgroup B1 was 0.06 ± 0.41 mm and did not differ from that in other knees of Subgroup B (P=0.87). The standardized response mean (SRM) in all 590 knees and Subgroups A, B and B1 was 0.25, 0.34, 0.17 and 0.06, respectively. Independent of IMD(BL), JSN correlated significantly with the difference between the IMDs in the two radiographs (r=0.17, P=0.0001).


CONCLUSION
Skewed MTP alignment in serial films and poor replication of IMD(BL) in the follow-up exam affect JSN measurement. The magnitude of change in joint space width (JSW) related to the poor quality of alignment that is common with the FF view jeopardizes accurate evaluation of JSN.
Multiple View Geometry in Computer Vision

Downloading the book in this website lists can give you more advantages. It will show you the best book collections and completed collections. So many books can be found in this website. So, this is not only this multiple view geometry in computer vision. However, this book is referred to read because it is an inspiring book to give you more chance to get experiences and also thoughts. This is simple, read the soft file of the book and you get it.
Correlates of physicians' prevention-related practices. Findings from the Women Physicians' Health Study.

BACKGROUND
Determinants of physicians' prevention-related counseling and screening practices are not well understood. Such determinants are worth knowing because we can then intervene on malleable variables and produce physicians with stronger prevention-related skills. Of the few such variables that have been examined, they have typically only been studied in univariate analyses or in small or otherwise limited populations and have been especially sparsely studied in women physicians.


OBJECTIVE
To explore the effect of potential counseling- and screening-related variables in 4501 respondents to the Women Physicians' Health Study, a questionnaire-based study of a representative sample of US women MDs.


RESULTS
Being a primary care practitioner and practicing a related health habit oneself were significantly correlated with reporting counseling and screening for all prevention-related variables examined. Current attempts to improve a related habit oneself, ethnicity, region, practice site, and amount of continuing medical education were sometimes significantly correlated with counseling and screening; most other variables studied (i.e., personal health status, a personal or family history of disease, control of work environment, and career satisfaction) were rarely significantly correlated.


CONCLUSIONS
Being a primary care practitioner and having related healthy habits oneself were the most significant correlates of US women physicians' self-reported prevention-related counseling and screening practices. These findings suggest potential new directions for physician training.
Vagus nerve stimulation in children with refractory seizures associated with Lennox-Gastaut syndrome.

PURPOSE
Vagus nerve stimulation (VNS) is approved for use for refractory partial seizures. Nevertheless, information regarding VNS therapy for special populations, including Lennox-Gastaut syndrome (LGS) is limited. We discuss the effectiveness, tolerability, and safety of VNS therapy in patients with LGS.


METHODS
A six-center, retrospective study evaluated the effectiveness of VNS therapy in patients with LGS at 3 and 6 months and compared preimplant and postimplant seizure frequency. Adverse effects and quality of life (QOL) were included as secondary measures.


RESULTS
Fifty patients, median age 13 years, with medically refractory epilepsy, were implanted. Median age at onset of seizures was 1.4 years, and a median of nine anticonvulsants (AEDs) had been tried before implantation. Data-collection forms were designed for retrospectively gathering data on each patient's preimplant history, seizures, implants, device settings, QOL, and adverse events. Median reductions in total seizures were 42% at 1 month, 58.2% at 3 months, and 57.9% at 6 months. The most common adverse events reported were voice alteration and coughing during stimulation. Other uncommon adverse events included increased drooling and behavioral changes. Investigators noted that QOL had improved for some patients in the study.


CONCLUSIONS
VNS is an effective treatment for medically refractory epilepsy in LGS. This treatment is well tolerated, safe, and may improve QOL.
On GANs and GMMs

A longstanding problem in machine learning is to find unsupervised methods that can learn the statistical structure of high dimensional signals. In recent years, GANs have gained much attention as a possible solution to the problem, and in particular have shown the ability to generate remarkably realistic high resolution sampled images. At the same time, many authors have pointed out that GANs may fail to model the full distribution ("mode collapse") and that using the learned models for anything other than generating samples may be very difficult. In this paper, we examine the utility of GANs in learning statistical models of images by comparing them to perhaps the simplest statistical model, the Gaussian Mixture Model. First, we present a simple method to evaluate generative models based on relative proportions of samples that fall into predetermined bins. Unlike previous automatic methods for evaluating models, our method does not rely on an additional neural network nor does it require approximating intractable computations. Second, we compare the performance of GANs to GMMs trained on the same datasets. While GMMs have previously been shown to be successful in modeling small patches of images, we show how to train them on full sized images despite the high dimensionality. Our results show that GMMs can generate realistic samples (although less sharp than those of GANs) but also capture the full distribution, which GANs fail to do. Furthermore, GMMs allow efficient inference and explicit representation of the underlying statistical structure. Finally, we discuss how GMMs can be used to generate sharp images. 1