LLukas22/scidocs huggingface dataset:
Sociodemographic correlates of stage of adoption for colorectal cancer screening in African Americans.

OBJECTIVES
African Americans have the highest incidence and mortality rates from colorectal cancer in the United States. Endoscopic screening, while effective in reducing both, is greatly underutilized. This research sought to understand sociodemographic factors related to stage of readiness for endoscopic screening.


DESIGN
One hundred fifty nine African American women (76.1%) and men (mean age = 57.0 years) who were non-adherent to endoscopic screening guidelines were recruited and asked to complete semi-structured interviews.


SETTING
Participants were all being seen for a non-acute primary care medical visit at one of two urban hospitals. The theoretical framework that informed this study was the Trans-theoretical Model (TTM) and the emphasis on Stage of Change or intention for undergoing endoscopic screening.


MAIN OUTCOME AND MEASURES
Based on their stage of readiness to undergo screening, 67 (42%) were categorized as precontemplative (Has no plans to have a colonoscopy) while 92 were categoriezed as being in a contemplative or preparation stage. Using chi-square and Student t-tests, differences were examined between the two groups.


RESULTS
No sociodemographic variables distinguished the two groups. However, people in the contemplative/preparation group were more likely to: have a regularly seen healthcare professional (63.7% vs 36.3%; P = .005), have had a previous recommendation for screening (65.7% vs 34.3%; P = .003); had heard of a colonoscopy (63.6% vs 36.4%; P = .000) and have been told by a healthcare professional that they needed a colonoscopy (73.1% vs 26.9%; P = .000).


CONCLUSIONS
This study helps us to better understand the relevance of sociodemographic characteristics that may be associated with completing endoscopic colorectal cancer screening. In addition, we confirm that physician recommendation and individual awareness of the procedure are significant factors in readiness to get screened.
VRun: running-in-place virtual reality exergame

Exercise is important for health and well-being. However, for some people it can be hard to find the time or motivation to get the recommended amount every day. Exergames on modern gaming consoles have demonstrated potential to address this problem, by helping people stay motivated, which subsequently benefited their health. Fully-immersive virtual reality has the potential to achieve similar benefits. In this paper we present VRun, a virtual reality exergame developed for Google Cardboard. The game requires the user to physically run through a virtual world, with activity detected through the smartphone's accelerometer. We performed an evaluation of the game in three different formats, comparing virtual reality with a large wall display and a baseline laptop. This is the first evaluation of a running-in-place virtual reality exergame.
Staying well during pregnancy and the postpartum: A pilot randomized trial of mindfulness-based cognitive therapy for the prevention of depressive relapse/recurrence.

OBJECTIVE
Clinical decision-making regarding the prevention of depression is complex for pregnant women with histories of depression and their health care providers. Pregnant women with histories of depression report preference for nonpharmacological care, but few evidence-based options exist. Mindfulness-based cognitive therapy has strong evidence in the prevention of depressive relapse/recurrence among general populations and indications of promise as adapted for perinatal depression (MBCT-PD). With a pilot randomized clinical trial, our aim was to evaluate treatment acceptability and efficacy of MBCT-PD relative to treatment as usual (TAU).


METHOD
Pregnant adult women with depression histories were recruited from obstetric clinics at 2 sites and randomized to MBCT-PD (N = 43) or TAU (N = 43). Treatment acceptability was measured by assessing completion of sessions, at-home practice, and satisfaction. Clinical outcomes were interview-based depression relapse/recurrence status and self-reported depressive symptoms through 6 months postpartum.


RESULTS
Consistent with predictions, MBCT-PD for at-risk pregnant women was acceptable based on rates of completion of sessions and at-home practice assignments, and satisfaction with services was significantly higher for MBCT-PD than TAU. Moreover, at-risk women randomly assigned to MBCT-PD reported significantly improved depressive outcomes compared with participants receiving TAU, including significantly lower rates of depressive relapse/recurrence and lower depressive symptom severity during the course of the study.


CONCLUSIONS
MBCT-PD is an acceptable and clinically beneficial program for pregnant women with histories of depression; teaching the skills and practices of mindfulness meditation and cognitive-behavioral therapy during pregnancy may help to reduce the risk of depression during an important transition in many women's lives.
Response assessment in patients with multiple myeloma during antiangiogenic therapy using arterial spin labeling and diffusion-weighted imaging: a feasibility study.

RATIONALE AND OBJECTIVES
To determine whether response to anti-angiogenic therapy in patients with multiple myeloma can be assessed by noncontrast perfusion magnetic resonance imaging (MRI) (ie, arterial-spin-labeling [ASL]), and diffusion-weighted [DWI] MRI.


MATERIALS AND METHODS
The study protocol was approved by the local institutional ethic board. Ten consecutive patients (eight men, two women; mean age 60.5 ± 8.5 years) with Stage III multiple myeloma were prospectively included. MRI was performed at baseline, as well as 3 and 8 weeks after onset of antiangiogenic therapy. Functional MRI data were compared with clinical outcome and conventional lesion size and signal-intensity measurements. Differences between baseline and follow-up values for ASL-MRI and DWI-MRI were assessed using a paired Student t-test.


RESULTS
Nine patients responded well to therapy, whereas one patient was classified a nonresponder. Temporary changes in signal intensity between baseline and follow-up examinations were inconsistent on T1-weighted (w) and T2w images. Likewise, determination of lesion size at follow-up proved unreliable. ASL showed a marked decrease in perfusion from baseline (251 ± 159 mL/(min*100g)) to follow-up at 3 weeks (115 ± 85 mL/(min*100g), P = .01) and 8 weeks (101 ± 90 mL/(min*100g, P = .01), respectively. Relative to the baseline examination, mean diffusion increased from 0.68 ± 0.19 × 10(-3) s/mm(2) at baseline to 0.94 ± 0.24 × 10(-3) s/mm(2) after 3 weeks (P = .04), and 0.96 ± 0.40 × 10(-3) s/mm(2) after 8 weeks (P = .049). Both methods were able to correctly classify 9/10 patients as responder or nonresponder.


CONCLUSION
ASL perfusion as well as DWI-MRI provide accurate, clinically relevant information regarding tumor viability and can predict response already early after therapy onset, as opposed to classical lesion size and MRI signal-intensity measurements.
Computer-aided detection (CAD): the case for

OBJECTIVES
The aim of this study was to estimate the effect of service screening, as provided by the NHS breast screening programme, on breast cancer mortality in Wales. Furthermore, we wished to ascertain whether a reduction in breast cancer mortality consistent with that observed in the randomised screening trials was being achieved.


SETTING
The NHS Breast Screening Programme in Wales, managed by Breast Test Wales, with headquarters in Cardiff.


METHODS
A case-control study design with 1:2 matching. The cases were deaths from breast cancer in women aged 50-75 years at diagnosis who were diagnosed after the instigation of screening in 1991 and who died after 1998. The controls were women who had not died of breast cancer or any other condition during the study period. One was from the same GP practice and the other from a different GP practice within the same district, matched by year of birth.


RESULTS
Based on 419 cases, the odds ratio for risk of death from breast cancer for women who have attended at least one routine screen compared to those never screened was 0.62 (95% confidence interval [CI] 0.47-0.82, p=0.001). After excluding cases diagnosed prior to 1995 and adjusting for self-selection bias, the estimated mortality reduction was 25% (odds ratio=0.75, 95% CI 0.49-1.14, p=0.09).


CONCLUSION
The Breast Test Wales screening programme is achieving a reduction in breast cancer mortality of 25% in women attending for screening, which is consistent with the results of the randomized controlled trials of mammographic screening.
Mechanical Fluctuations of the Membrane–Skeleton Are Dependent on F-Actin ATPase in Human Erythrocytes 

Cell membrane fluctuations (CMF) of human erythrocytes, measured by point dark field microscopy, were shown to depend, to a large extent, on intracellular MgATP (Levin, S.V., and R. Korenstein. 1991. Biophys. J. 60:733-737). The present study extends that investigation and associates CMF with F-actin's ATPase activity. MgATP was found to reconstitute CMF in red blood cell (RBC) ghosts and RBC skeletons to their levels in intact RBCs, with an apparent Kd of 0.29 mM. However, neither non-hydrolyzable ATP analogues (AMP-PNP, ATPgammaS) nor hydrolyzable ones (ITP, GTP), were able to elevate CMF levels. The inhibition of ATPase activity associated with the RBC's skeleton, carried out either by the omission of the MgATP substrate or by the use of several inhibitors (vanadate, phalloidin, and DNase I), resulted in a strong decrease of CMF. We suggest that the actin's ATPase, located at the pointed end of the short actin filament, is responsible for the MgATP stimulation of CMF in RBCs.
Principles of constraint programming

Inevitably, reading is one of the requirements to be undergone. To improve the performance and quality, someone needs to have something new every day. It will suggest you to have more inspirations, then. However, the needs of inspirations will make you searching for some sources. Even from the other people experience, internet, and many books. Books and internet are the recommended media to help you improving your quality and performance.
Experimental Design for Human-in-the-Loop Driving Simulations

In order to develop provably safe human-in-the-loop systems, accurate and precise models of human behavior must be developed. Driving and flying are examples of human-in-the-loop systems that both require models of human behavior and are safety critical. This report describes a new experimental setup for human-in-theloop simulations. We focus on developing testbed for collecting driver data that allows us to collect realistic data, while maintaining safety and control of the environmental surroundings. A force feedback simulator with four axis motion has been setup for real-time driving experiments. The simulator will move to simulate the forces a driver feels while driving, which allows for a realistic experience for the driver. This setup allows for flexibility and control for the researcher in a realistic simulation environment. Experiments concerning driver distraction can also be carried out safely in this test bed, in addition to multi-agent experiments. We present an application in driver modeling, in which we attempt to predict driver behavior over long time horizons for use in a semi-autonomous framework. We extend previous work that focuses on set predictions consisting of trajectories observed from the nonlinear dynamics and behaviors of the human driven car, accounting for the driver mental state, the context or situation that the vehicle is in, and the surrounding environment in both highway and intersection scenarios. By using this realistic data and flexible algorithm, a precise and accurate driver model can be developed that is tailored to an individual.
Gender Differences in the Nature of the Intimate Partner Violence and Effects of Perpetrator Arrest on Revictimization

The majority of research on intimate partner violence (IPV) has addressed male-to-female violence, although a small but growing body of literature has developed that explores males victimized by female partners. This study used data from the National Crime Victimization Survey from 1987 to 2003 to examine male victimization by comparing the nature of violence to female victimization and by exploring the effect of perpetrator arrest on preventing revictimization. The sample was comprised of 2,462 female and 298 male victims. Study variables included gender, arrest, revictimization, type of violence, injury, and use of a weapon. Results showed that men were victimized by IPV less frequently than women and received fewer injuries, although they were more likely to experience more severe violence. Police arrested female perpetrators, but generally only if injury was involved; however, arrest did not reduce male victims’ chance of revictimization.
Energy conversion in natural and artificial photosynthesis.

Modern civilization is dependent upon fossil fuels, a nonrenewable energy source originally provided by the storage of solar energy. Fossil-fuel dependence has severe consequences, including energy security issues and greenhouse gas emissions. The consequences of fossil-fuel dependence could be avoided by fuel-producing artificial systems that mimic natural photosynthesis, directly converting solar energy to fuel. This review describes the three key components of solar energy conversion in photosynthesis: light harvesting, charge separation, and catalysis. These processes are compared in natural and in artificial systems. Such a comparison can assist in understanding the general principles of photosynthesis and in developing working devices, including photoelectrochemical cells, for solar energy conversion.
Influence of energetically active carbon on thermodynamics and phase relationship of U-C-N system

Abstract The reactions of UN with graphite and of UN with active carbon have been investigated at 1300°C and 1400°C under a variety of pressures of nitrogen gas. Results show that, at fixed pressure, the nitrogen content of the equilibrium UC-UN solid solution formed in the presence of graphite is higher than in the equilibrium UC-UN solid solution formed in the presence of active carbon. A brief thermodynamic argument explains the result in terms of the differing chemical potentials between graphite and active carbon.
Final results from a multicenter, international, pivotal study of romidepsin in refractory cutaneous T-cell lymphoma.

PURPOSE
The primary objective of this study was to confirm the efficacy of romidepsin in patients with treatment refractory cutaneous T-cell lymphoma (CTCL).


PATIENTS AND METHODS
This international, pivotal, single-arm, open-label, phase II study was conducted in patients with stage IB to IVA CTCL who had received one or more prior systemic therapies. Patients received romidepsin as an intravenous infusion at a dose of 14 mg/m(2) on days 1, 8, and 15 every 28 days. Response was determined by a composite assessment of total tumor burden including cutaneous disease, lymph node involvement, and blood (Sézary cells).


RESULTS
Ninety-six patients were enrolled and received one or more doses of romidepsin. Most patients (71%) had advanced stage disease (≥ IIB). The response rate was 34% (primary end point), including six patients with complete response (CR). Twenty-six of 68 patients (38%) with advanced disease achieved a response, including five CRs. The median time to response was 2 months, and the median duration of response was 15 months. A clinically meaningful improvement in pruritus was observed in 28 (43%) of 65 patients, including patients who did not achieve an objective response. Median duration of reduction in pruritus was 6 months. Drug-related adverse events were generally mild and consisted mainly of GI disturbances and asthenic conditions. Nonspecific, reversible ECG changes were noted in some patients.


CONCLUSION
Romidepsin has significant and sustainable single-agent activity (including improvement in pruritus) and an acceptable safety profile, making it an important therapeutic option for treatment refractory CTCL.
Intelligent content delivery over wireless via SDN

On the Internet, most traffic is generated by content delivery applications such as video streaming, P2P and web surfing. With the proliferation of mobile applications that offer on-demand access to services, the ability to track end-user's perceived service quality has become a pivotal aspect for future networks such as 5G. Software-defined networking (SDN) and network functions virtualization (NFV) in the mobile core offer unprecedented flexibility for opportunistic traffic steering, leading to advanced levels of quality-of-service (QoS) control. We leverage the SDN concept to dynamically control network traffic over wide area networks (WANs) from edge nodes of wireless networks (e.g., a packet data network gateway in LTE), depending on changing network conditions and application types. Our SDN-based application-aware routing system allows mobile network operators to achieve better utilization of their networks, service providers to improve customer satisfaction, and end-users to experience desirable service quality for various network applications. As for a prototype, we attach 802.11g to Mininet's virtual networks in order to show the feasibility of our approach.
Complete positivity and neutron interferometry

Abstract We analyze the dynamics of neutron beams in interferometry experiments using quantum dynamical semigroups. We show that these experiments could provide stringent limits on the non-standard, dissipative terms appearing in the extended evolution equations.
Large granular lymphocyte leukemia as a complication of rheumatoid arthritis.

Large granular lymphocyte leukemia is a rare entity belonging to same spectrum of diseases than Felty's syndrome, which might occur in patients with long-standing rheumatoid arthritis. It is clinically characterized by persistent neutropenia and recurrent bacterial infections associated with the presence in both peripheral blood and bone marrow of clonal expansion of atypic lymphocytes with a cytotoxic T cell phenotype, or less frequently an NK-cell phenotype, as well as splenomegaly. It is more frequently diagnosed in seropositive rheumatoid arthritis, with significant structural damage, extra-articular manifestations and persistently elevated values of ESR, despite them havubg low inflammatory joint activity. We report the case of a 70 year old male with a long-standing rheumatoid arthritis, who developed septic shock secondary to prosthetic hip infection by Salmonella spp. He showed persistent neutropenia, and an aberrant monoclonal T cell population was detected in both peripheral blood and bone marrow, consistent with large granular lymphocyte leukemia.
Phase 1 study of XL119, a rebeccamycin analog, in patients with refractory hematologic malignancies.

BACKGROUND
XL119 is a water-soluble derivative of rebeccamycin with dose-dependent myelosuppression as dose-limiting toxicity in phase 1 studies of solid tumors. A phase 1 study was conducted to determine the maximum tolerated dose and toxicities of XL119 in patients with advanced myelodysplastic syndrome and relapsed or refractory acute leukemias.


METHODS
Thirty-one patients were treated at 7 dose levels ranging from 140 to 260 mg/m(2)/daily times 5 in a 21-day cycle. Consenting patients had correlative biologic parameters studied.


RESULTS
Dose-limiting toxicity was grade 3/4 mucositis. The recommended phase 2 dose in hematologic malignancies is 240 mg/m(2)/daily times 5 in a 21-day cycle. Clinically significant reduction in bone marrow blasts were seen in 5 patients and additional patients had reductions in peripheral blood blasts. However, the responses were transient. Changes of plasma vascular endothelial growth factor levels from Day 1 to Day 7 correlated negatively with changes in peripheral blood blasts from Day 1 to Day 7.


CONCLUSIONS
Further assessment of XL119 in combination with other agents in patients with acute leukemias and high-risk myelodysplastic syndrome is warranted.
LVDC distribution system protection — Solutions, implementation and measurements

An LVDC (low voltage DC) distribution system is a promising technology to be used in future smart distribution system having high level cost-efficiency and reliability. Protection of an LVDC distribution system differs from the traditional 20/0.4 kV AC distribution network; direct current and IT network complicates the customer-end protection. This paper describes practical protection solutions for the LVDC network and presents an LVDC system laboratory prototype in which experimental testing is performed.
Effects of femoral rotational taping on pain, lower extremity kinematics, and muscle activation in female patients with patellofemoral pain.

OBJECTIVES
To explore the hip and knee joint kinematics as well as muscle activation between participants with patellofemoral pain syndrome (PFPS) and controls, and to investigate the immediate effect of proximal femoral rotational taping on pain, joint kinematics, and muscle activation during single-leg squat (SLS).


DESIGN
Cross-sectional study.


METHODS
Sixteen female participants with PFPS, and eight healthy female controls participated. Three-dimensional hip and patellar kinematics measured by electromagnetic tracking system, hip (gluteus maximus and gluteus medius) and thigh (rectus femoris) muscle activation measured by EMG, and subjective report of pain were recorded during SLS in three randomized conditions of no tape, sham taping, and femoral rotational taping with kinesiotape.


RESULTS
Without taping, compared with controls, PFPS group had increased hip adduction angle (23.5±11.3° vs. 15.8±7.3°) during SLS. Additionally, PFPS group exhibited lesser rectus femoris activity during the initial 0-15° of SLS. Application of both femoral rotational and sham tapes reduced pain for PFPS group. Compared with no tape or sham tape, femoral rotational tape significantly shifted the patella into more posterior (1.59±0.83cm in no tape vs. 1.54±0.87cm in sham tape vs. 1.32±0.72cm in femoral rotational tape) and distal (-2.49±0.95cm vs. -2.64±0.80cm vs. -3.11±0.77cm) positions in the PFPS group.


CONCLUSIONS
Femoral rotational taping could alter patellofemoral kinematics and decrease pain in treatment of young female participants with PFPS.
Intersubjective Culture: The Role of Intersubjective Perceptions in Cross-Cultural Research.

Intersubjective perceptions refer to shared perceptions of the psychological characteristics that are widespread within a culture. In this article, we propose the intersubjective approach as a new approach to understanding the role that culture plays in human behavior. In this approach, intersubjective perceptions, which are distinct from personal values and beliefs, mediate the effect of the ecology on individuals' responses and adaptations. We review evidence that attests to the validity and utility of the intersubjective approach in explicating culture's influence on human behaviors and discuss the implications of this approach for understanding the interaction between the individual, ecology, and culture; the nature of cultural competence; management of multicultural identities; cultural change; and measurement of culture.