LLukas22/scidocs huggingface dataset:
Pomalidomide: evaluation of cytochrome P450 and transporter-mediated drug-drug interaction potential in vitro and in healthy subjects.

Pomalidomide offers an alternative for patients with relapsed/refractory multiple myeloma who have exhausted treatment options with lenalidomide and bortezomib. Little is known about pomalidomide's potential for drug-drug interactions (DDIs); as pomalidomide clearance includes hydrolysis and cytochrome P450 (CYP450)-mediated hydroxylation, possible DDIs via CYP450 and drug-transporter proteins were investigated in vitro and in a clinical study. In vitro pomalidomide was neither an inducer nor inhibitor of CYP450, nor an inhibitor of transporter proteins P glycoprotein (P-gp), BCRP, OAT1, OAT3, OCT2, OATP1B1, and OATP1B3. Oxidative metabolism of pomalidomide was predominately mediated by CYP1A2 and CYP3A4, and pomalidomide was shown to be a P-gp substrate. In healthy males, co-administration of oral (4 mg) pomalidomide with ketoconazole (CYP3A/P-gp inhibitor) or carbamazepine (CYP3A/P-gp inducer) did not result in clinically relevant changes in pomalidomide exposure. Co-administration of pomalidomide with fluvoxamine (CYP1A2 inhibitor) in the presence of ketoconazole approximately doubled pomalidomide exposure. Pomalidomide appears to have low potential for clinically relevant DDI and is unlikely to affect the clinical exposure of other drugs. Avoid co-administration of strong CYP1A2 inhibitors unless medically necessary. Pomalidomide dose should be reduced by 50% if co-administered with strong CYP1A2 inhibitors and strong CYP3A/P-gp inhibitors.
Musculoskeletal Lower Limb Injury Risk in Army Populations

Injuries are common within military populations, with high incidence rates well established in the literature. Injuries cause a substantial number of working days lost, a significant cost through compensation claims and an increased risk of attrition. In an effort to address this, a considerable amount of research has gone into identifying the most prevalent types of injury and their associated risk factors. Collective evidence suggests that training and equipment contribute to a large proportion of the injuries sustained. In particular, the large loads borne by soldiers, the high intensity training programs and the influence of footwear have been identified as significant causative factors of lower limb injury in military populations. A number of preventative strategies have been developed within military bodies around the world to address these issues. The relative success of these strategies is highly variable; however, with advancements in technology, new approaches will become available and existing strategies may become more effective.
Leadership and organizational change for implementation (LOCI): a randomized mixed method pilot study of a leadership and organization development intervention for evidence-based practice implementation

BACKGROUND
Leadership is important in the implementation of innovation in business, health, and allied health care settings. Yet there is a need for empirically validated organizational interventions for coordinated leadership and organizational development strategies to facilitate effective evidence-based practice (EBP) implementation. This paper describes the initial feasibility, acceptability, and perceived utility of the Leadership and Organizational Change for Implementation (LOCI) intervention. A transdisciplinary team of investigators and community stakeholders worked together to develop and test a leadership and organizational strategy to promote effective leadership for implementing EBPs.


METHODS
Participants were 12 mental health service team leaders and their staff (n = 100) from three different agencies that provide mental health services to children and families in California, USA. Supervisors were randomly assigned to the 6-month LOCI intervention or to a two-session leadership webinar control condition provided by a well-known leadership training organization. We utilized mixed methods with quantitative surveys and qualitative data collected via surveys and a focus group with LOCI trainees.


RESULTS
Quantitative and qualitative analyses support the LOCI training and organizational strategy intervention in regard to feasibility, acceptability, and perceived utility, as well as impact on leader and supervisee-rated outcomes.


CONCLUSIONS
The LOCI leadership and organizational change for implementation intervention is a feasible and acceptable strategy that has utility to improve staff-rated leadership for EBP implementation. Further studies are needed to conduct rigorous tests of the proximal and distal impacts of LOCI on leader behaviors, implementation leadership, organizational context, and implementation outcomes. The results of this study suggest that LOCI may be a viable strategy to support organizations in preparing for the implementation and sustainment of EBP.
Non-standard analysis in ACA0 and Riemann mapping theorem

This research is motivated by the program of reverse mathematics and non-standard arguments in second-order arithmetic. Within a weak subsystem of second-order arithmetic ACA0, we investigate some aspects of non-standard analysis related to sequential compactness. Then, using arguments of non-standard analysis, we show the equivalence of the Riemann mapping theorem and ACA0 over WKL0. (© 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)
Digital creativity: Research themes and framework

Digital creativity is defined as the creativity manifested in all forms that are driven by digital technologies. Due to its novelty and interdisciplinary nature, the scope, perspective, and main research themes of digital creativity study are still unclear to date. Therefore, we utilized the intellectual structure technique developed by the information scientist to help clarify the scope and themes of this research domain. We analyzed 3591 relevant literatures and tentatively identified major research themes to facilitate the comprehension and study of digital creativity. The resulting framework summarizes the progress in digital creativity research and provides future research directions. 2014 Published by Elsevier Ltd.
Proper Orthogonal Decomposition for Linear-Quadratic Optimal Control

Optimal control problems for partial differential equation are often hard to tackle numerically because their discretization leads to very large scale optimization problems. Therefore, different techniques of model reduction were developed to approximate these problems by smaller ones that are tractable with less effort. Balanced truncation [2, 65, 80] is one well studied model reduction technique for state-space systems. This method utilizes the solutions to two Lyapunov equations, the so-called controllability and observability Gramians. The balanced truncation method is based on transforming the state-space system into a balanced form so that its controllability and observability Gramians become diagonal and equal. Moreover, the states that are difficult to reach or to observe, are truncated. The advantage of this method is that it preserves the asymptotic stability in the reduced-order system. Furthermore, a-priori error bounds are available. Recently, the theory of balanced truncation model reduction was extended to descriptor systems; see, e.g., [49] and [21]. Recently the application of reduced-order models to linear time varying and nonlinear systems, in particular to nonlinear control systems, has received
Cyclic codes over the ring 𝔽p[u, v] / 〈uk, v2, uv-vu〉

Article history: Received 4 June 2014 Received in revised form 29 December 2014 Accepted 13 January 2015 Available online xxxx Communicated by W. Cary Huffman
High-Efficiency High Step-Up DC–DC Converter With Dual Coupled Inductors for Grid-Connected Photovoltaic Systems

This paper introduces a non-isolated high step-up dc–dc converter with dual coupled inductors suitable for distributed generation applications. By implementing an input parallel connection, the proposed dc–dc structure inherits shared input current with low ripple, which also requires small capacitive filter at its input. Moreover, this topology can reach high voltage gain by using dual coupled inductors in series connection at the output stage. The proposed converter uses active clamp circuits with a shared clamp capacitor for the main switches. In addition to the active clamp circuit, the leakage energy is recycled to the output by using an integrated regenerative snubber. Indeed, these circuits allow soft-switching conditions, i.e., zero voltage switching and zero current switching for active and passive switching devices, respectively. The mentioned features along with a common ground connection of the input and output make the proposed topology a proper candidate for transformer-less grid-connected photovoltaic systems. The operating performance, analysis and mathematical derivations of the proposed dc–dc converter have been demonstrated in the paper. Moreover, the main features of the proposed converter have been verified through experimental results of a 1-kW laboratory prototype.
The sensitivity and specificity of 0.5% apraclonidine in the diagnosis of oculosympathetic paresis.

AIMS
To evaluate the sensitivity and specificity of 0.5% apraclonidine test in the diagnosis of oculosympathetic paresis (OSP).


METHOD
Apraclonidine (0.5%) was administered to 31 eyes, nine with a diagnosis of Horner syndrome (HS), 22 with bilateral OSP caused by diabetes, and to 54 control eyes. All were confirmed with the cocaine test. The effects on pupil diameter and upper eyelid level were observed 1 hour later.


RESULTS
Apraclonidine caused a mean dilation of 2.04 mm (range 1--4.5) (p<0.001) in the pupils with OSP and it caused pupillary constriction in the control eyes with a mean change of -0.14 mm (range 0.5 to --1) (p<0.05). It caused reversal of anisocoria in all HS cases. Its effects on both pupil diameters and upper lid levels differed significantly between the groups (p<0.001). The mean elevation in the upper lid was 1.75 mm (range 1--4) in the OSP group (p<0.001) and 0.61 mm (range 0--3) in the control group (p<0.001).


CONCLUSION
The effect of the apraclonidine (0.5%) test on the pupil diameter was diagnostic for OSP and had at least the same sensitivity and specificity as the cocaine test for the diagnosis of OSP.
ΔI = rule from staggered fermions.

Abstract We present our latest results for the Δ I = 1 2 rule, obtained on quenched ensembles with β = 6.0 and 6.2, and a set of N f = 2 configurations with β = 5.7. The statistical noise is quite under control. We observe an enhancement of the Δ I = 1 2 amplitude consistent with experiment, although the systematic errors are still large. We also present a non-perturbative determination of Z P , Z S and the strange quark mass. We briefly discuss our progress in calculating e′/e.
Impact of aortic stiffness attenuation on survival of patients in end-stage renal failure.

BACKGROUND
Aortic pulse wave velocity (PWV) is a predictor of mortality in patients with end-stage renal failure (ESRF). The PWV is partly dependent on blood pressure (BP), and a decrease in BP can attenuate the stiffness. Whether the changes in PWV in response to decreases in BP can predict mortality in ESRF patients has never been investigated.


METHODS AND RESULTS
One hundred fifty ESRF patients (aged 52+/-16 years) were monitored for 51+/-38 months. From entry until the end of follow-up, the changes of PWV in response to decreased BP were measured ultrasonographically. BP was controlled by adjustment of "dry weight" and, when necessary, with ACE inhibitors, calcium antagonists, and/or beta-blockers, in combination if necessary. Fifty-nine deaths occurred, including 40 cardiovascular and 19 noncardiovascular events. Cox analyses demonstrated that independent of BP changes, the predictors of all-cause and cardiovascular mortality were as follows: absence of PWV decrease in response to BP decrease, increased left ventricular mass, age, and preexisting cardiovascular disease. Survival was positively associated with ACE inhibitor use. After adjustment for all confounding factors, the risk ratio for the absence of PWV decrease was 2.59 (95% CI 1.51 to 4.43) for all-cause mortality and 2.35 (95% CI 1.23 to 4.41) for cardiovascular mortality. The risk ratio for ACE inhibitor use was 0.19 (95% CI 0.14 to 0.43) for all-cause mortality and 0.18 (95% CI 0.06 to 0.55) for cardiovascular mortality.


CONCLUSIONS
These results indicate that in ESRF patients, the insensitivity of PWV to decreased BP is an independent predictor of mortality and that use of ACE inhibitors has a favorable effect on survival that is independent of BP changes.
Improving High School English Language Learners' Second Language Listening Through Strategy Instruction

High school English language learners need strong oral comprehension skills for access to oral content in their academic classes. Unfortunately, instruction in effective listening strategies is often not part of their English as a Second Language (ESL) curriculum. This study tested the hypothesis that targeted listening strategy instruction in the ESL classroom results in improved listening comprehension that can be useful in English language learners’ academic content classes. After receiving 15 listening strategy training sessions, participants showed a statistically significant improvement in discrete and video listening ability, as well as note-taking ability. This study suggests that targeted listening strategy instruction should be part of the ESL curriculum. Sources for designing and implementing effective listening strategy instruction are provided, and research needs and designs are suggested.
Large-scale machine learning-based malware detection: confronting the "10-fold cross validation" scheme with reality

To address the issue of malware detection, researchers have recently started to investigate the capabilities of machine-learning techniques for proposing effective approaches. Several promising results were recorded in the literature, many approaches being assessed with the common "10-Fold cross validation" scheme. This paper revisits the purpose of malware detection to discuss the adequacy of the "10-Fold" scheme for validating techniques that may not perform well in reality. To this end, we have devised several Machine Learning classifiers that rely on a novel set of features built from applications' CFGs. We use a sizeable dataset of over 50,000 Android applications collected from sources where state-of-the art approaches have selected their data. We show that our approach outperforms existing machine learning-based approaches. However, this high performance on usual-size datasets does not translate in high performance in the wild.
Image Synthesis for Self-Supervised Visual Representation Learning

Image Synthesis for Self-Supervised Visual Representation Learning
A Budget Model for Information Security

This paper presents a model to assist in deriving a cost-effective and optimal information security budget. The derived budget focuses on an adequate mix of administrative, operational and environmental controls enabling organizations to comply with relevant regulatory mandates. The results seek to provide guidance on how decision makers can achieve optimal protection of their information assets in the face of shrinking information security budgets. A case study illustrates the implementation of the proposed model.
Risk Factors Associated With Corneal Nerve Alteration in Type 1 Diabetes in the Absence of Neuropathy: A Longitudinal In Vivo Corneal Confocal Microscopy Study.

PURPOSE
The aim of this study was to determine alterations to the corneal subbasal nerve plexus (SNP) over 4 years using in vivo corneal confocal microscopy in participants with type 1 diabetes and to identify significant risk factors associated with these alterations.


METHODS
A cohort of 108 individuals with type 1 diabetes and no evidence of peripheral neuropathy at enrollment underwent laser-scanning in vivo corneal confocal microscopy, ocular screening, and health and metabolic assessment at baseline, and the examinations continued for 4 subsequent annual visits. At each annual visit, 8 central corneal images of the SNP were selected and analyzed to quantify corneal nerve fiber density, corneal nerve branch density and corneal nerve fiber length. Linear mixed model approaches were fitted to examine the relationship between risk factors and corneal nerve parameters.


RESULTS
A total of 96 participants completed the final visit and 91 participants completed all visits. No significant relationships were found between corneal nerve parameters and time, sex, duration of diabetes, smoking, alcohol consumption, blood pressure, or body mass index. However, corneal nerve fiber density was negatively associated with glycated hemoglobin (β = -0.76, P < 0.01) and age (β = -0.13, P < 0.01) and positively related to high-density lipids (β = 2.01, P = 0.03). Higher glycated hemoglobin (β = -1.58, P = 0.04) and age (β = -0.23, P < 0.01) also negatively impacted corneal nerve branch density. Corneal nerve fiber length was only affected by higher age (β = -0.06, P < 0.01).


CONCLUSIONS
Glycemic control, high-density lipid, and age have significant effects on SNP structure. These findings highlight the importance of diabetic management to prevent corneal nerve damage and the capability of in vivo corneal confocal microscopy for monitoring subclinical alterations in the corneal SNP in diabetes.
Lock-free deques and doubly linked lists

We present a practical lock-free shared data structure that efficiently implements the operations of a concurrent deque as well as a general doubly linked list. The implementation supports parallelism for disjoint accesses and uses atomic primitives which are available in modern computer systems. Previously known lock-free algorithms of doubly linked lists are either based on non-available atomic synchronization primitives, only implement a subset of the functionality, or are not designed for disjoint accesses. Our algorithm only requires single-word compare-and-swap atomic primitives, supports fully dynamic list sizes, and allows traversal also through deleted nodes and thus avoids unnecessary operation retries. We have performed an empirical study of our new algorithm on two different multiprocessor platforms. Results of the experiments performed under high contention show that the performance of our implementation scales linearly with increasing number of processors. Considering deque implementations and systems with low concurrency, the algorithm by Michael shows the best performance. However, as our algorithm is designed for disjoint accesses, it performs significantly better on systems with high concurrency and non-uniform memory architecture. © 2008 Elsevier Inc. All rights reserved.
Abnormal B-cell cytokine responses a trigger of T-cell-mediated disease in MS?

OBJECTIVE
To study antibody-independent contributions of B cells to inflammatory disease activity, and the immune consequences of B-cell depletion with rituximab, in patients with multiple sclerosis (MS).


METHODS
B-Cell effector-cytokine responses were compared between MS patients and matched controls using a 3-signal model of activation. The effects of B-cell depletion on Th1/Th17 CD4 and CD8 T-cell responses in MS patients were assessed both ex vivo and in vivo, together with pharmacokinetic/pharmacodynamic studies as part of 2 rituximab clinical trials in relapsing-remitting MS.


RESULTS
B Cells of MS patients exhibited aberrant proinflammatory cytokine responses, including increased lymphotoxin (LT):interleukin-10 ratios and exaggerated LT and tumor necrosis factor (TNF)-alpha secretion, when activated in the context of the pathogen-associated TLR9-ligand CpG-DNA, or the Th1 cytokine interferon-gamma, respectively. B-Cell depletion, both ex vivo and in vivo, resulted in significantly diminished proinflammatory (Th1 and Th17) responses of both CD4 and CD8 T cells. Soluble products from activated B cells of untreated MS patients reconstituted the diminished T-cell responses observed following in vivo B-cell depletion in the same patients, and this effect appeared to be largely mediated by B-cell LT and TNFalpha.


INTERPRETATION
We propose that episodic triggering of abnormal B-cell cytokine responses mediates 'bystander activation' of disease-relevant proinflammatory T cells, resulting in new relapsing MS disease activity. Our findings point to a plausible mechanism for the long-recognized association between infections and new MS relapses, and provide novel insights into B-cell roles in both health and disease, and into mechanisms contributing to therapeutic effects of B-cell depletion in human autoimmune diseases, including MS.
Application of SVM and SVD technique based on EMD to the fault diagnosis of the rotating machinery

Targeting the characteristics that periodic impulses usually occur whilst the rotating machinery exhibits local faults and the limitations of singular value decomposition (SVD) techniques, the SVD technique based on empirical mode decomposition (EMD) is applied to the fault feature extraction of the rotating machinery vibration signals. The EMD method is used to decompose the vibration signal into a number of intrinsic mode functions (IMFs) by which the initial feature vector matrices could be formed automatically. By applying the SVD technique to the initial feature vector matrices, the singular values of matrices could be obtained, which could be used as the fault feature vectors of support vector machines (SVMs) classifier. The analysis results from the gear and roller bearing vibration signals show that the fault diagnosis method based on EMD, SVD and SVM can extract fault features effectively and classify working conditions and fault patterns of gears and roller bearings accurately even when the number of samples is small.
Novel Design of Ultrabroadband Radar Cross Section Reduction Surfaces Using Artificial Magnetic Conductors

A novel technique for designing ultrabroadband radar cross section (RCS) reduction surfaces using artificial magnetic conductors (AMCs) is proposed in this paper. This technique overcomes the fundamental limitation of the conventional checkerboard design where the reflection phase difference of (180±37)° is required to achieve 10-dB RCS reduction. Initially, a planar surface for broadband RCS reduction is designed with two properly selected AMCs in a blended checkerboard architecture. A 10-dB RCS reduction is observed for more than 83% of the bandwidth (3.9–9.45 GHz) with this blended checkerboard design. After modifying the blended checkerboard design using the proposed novel technique, the 10-dB RCS reduction bandwidth increased to 91% fractional bandwidth (3.75–10 GHz) as the criteria of (180 ± 37)° reflection phase difference is no longer required. Measured data show an excellent agreement between the predicted, simulated, and measured data. Bistatic performance of the surface at various frequencies is also presented. Key steps for designing ultrabroadband RCS reduction checkerboard surface are summarized.