LLukas22/scidocs huggingface dataset:
Preservation potential of ancient plankton DNA in Pleistocene marine sediments.

Recent studies have shown that ancient plankton DNA can be recovered from Holocene lacustrine and marine sediments, including from species that do not leave diagnostic microscopic fossils in the sediment record. Therefore, the analysis of this so-called fossil plankton DNA is a promising approach for refining paleoecological and paleoenvironmental information. However, further studies are needed to reveal whether DNA of past plankton is preserved beyond the Holocene. Here, we identified past eukaryotic plankton members based on 18S rRNA gene profiling in eastern Mediterranean Holocene and Pleistocene sapropels S1 (~9 ka), S3 (~80 ka), S4 (~105 ka), and S5 (~125 ka). The majority of preserved ~400- to 500-bp-long 18S rDNA fragments of microalgae that were studied in detail (i.e. from haptophyte algae and dinoflagellates) were found in the youngest sapropel S1, whereas their specific lipid biomarkers (long-chain alkenones and dinosterol) were also abundant in sediments deposited between 80 and 124 ka BP. The late-Pleistocene sediments mainly contained eukaryotic DNA of marine fungi and from terrestrial plants, which could have been introduced via the river Nile at the time of deposition and preserved in pollen grains. A parallel analysis of Branched and Isoprenoid Tetraethers (i.e. BIT index) showed that most of the organic matter in the eastern Mediterranean sediment record was of marine (e.g. pelagic) origin. Therefore, the predominance of terrestrial plant DNA over plankton DNA in older sapropels suggests a preferential degradation of marine plankton DNA.
Employee turnover prediction and retention policies design: a case study

This paper illustrates the similarities between the problems of customer churn and employee turnover. An example of employee turnover prediction model leveraging classical machine learning techniques is developed. Model outputs are then discussed to design & test employee retention policies. This type of retention discussion is, to our knowledge, innovative and constitutes the main value of this paper. 2010 Mathematics Subject Classification.
Facilitating safe care: a qualitative study of Iranian nurse leaders.

Aim  The purpose of this study was to explore and describe how nurse leaders facilitate safe care from the perspectives of both nurses and nurse leaders. Background  The health-care system's success in improving patient safety pivots on nursing leadership. However, there is a lack of knowledge in the international literature about how nurse leaders facilitate provision of safe care and reaching the goal of a safe health-care system. Method  A qualitative design using a content analysis approach was applied for data gathering and analysis. In this study, 20 nurses (16 nurses and four head nurses) working in a referral teaching hospital in Tehran, Iran, were recruited through purposive sampling. Semi-structured interviews and 10 hours of structured observations were conducted to collect data. Results  The data analysis resulted in three main themes: 'providing environmental prerequisites for safe nursing practice', 'uniting and integrating health-care providers', and 'creating an atmosphere of safe care'. Conclusion  The results indicate that to facilitate providing safe care, nurse leaders should improve nurses' working conditions, develop the nurses' practical competencies, assign duties to nurses according to their skills and capabilities, administer appropriate supervision, improve health-care providers' professional relationships and encourage their collaboration, empower nurses and reward their safe practice. Implications for nursing management  Approaching the challenge of patient safety requires the health-care system to combine its efforts and strategies with nursing leadership in its vital role of facilitating safe care and improving patient safety.
A comparative study of heuristic algorithms on Economic Lot Scheduling Problem

The Economic Lot Scheduling Problem (ELSP) has been well-researched for more than 40 years. As the ELSP has been generally seen as NP-hard, researchers have focused on the development of efficient heuristic approaches. In this paper, we consider the time-varying lot size approach to solve the ELSP. A computational study of the existing solution algorithms, Dobson’s heuristic, Hybrid Genetic algorithm, Neighborhood Search heuristics, Tabu Search and the newly proposed Simulated Annealing algorithm are presented. The reviewed methods are first tested on two well-known problems, those of Bomberger’s [Bomberger, E. E. (1966). A dynamic programming approach to a lot size scheduling problem. Management Science 12, 778–784] and Mallya’s [Mallya, R (1992). Multi-product scheduling on a single machine: A case study. OMEGA: International Journal of Management Science 20, 529–534] problems. We show the Simulated Annealing algorithm finds the best known solution to these problems. A similar comparison study is performed on various problem sets previously suggested in the literature. The results show that the Simulated Annealing algorithm outperforms Dobson’s heuristic, Hybrid Genetic algorithm and Neighborhood search heuristics on these problem sets. The Simulated Annealing algorithm also shows faster convergence than the best known Tabu Search algorithm, yet results in solutions of a similar quality. Finally, we report the results of the design of experiment study which compares the robustness of the mentioned meta-heuristic techniques. Crown copyright 2007 Published by Elsevier Ltd. All rights reserved.
Clarifying Obfuscation: Improving the Security of White-Box Encoding

To ensure the security of software executing on malicious hosts, as in digital rights management (DRM) applications, it is desirable to encrypt or decrypt content using white-box-encoded cryptographic algorithms in the manner of Chow et al. Such encoded algorithms must run on an adversarys machine without revealing the private key information used, despite the adversarys ability to observe and manipulate the running algorithm. We have implemented obfuscated (white-box) DES and 3DES algorithms along the lines of Chow et al., with alterations that improve the security of the key, eliminating attacks that extract the key from Chow et al.s obfuscated DES. Our system is secure against two previously published attacks on Chow et al.s system, as well as a new adaptation of a statistical bucketing attack on their system. During implementation of whitebox DES we found that a number of optimizations were needed for practical generation and execution. On a typical laptop we can generate obfuscated DES functions in a Lisp environment in under a minute allocating 11 MB, including the space required for the resulting function. The resulting function occupies 4.5 MB and encrypts or decrypts each block in approximately 30 ms on an 800 MHz G4 processor; slight run-time performance of the obfuscated DES could be traded to further reduce our algorithms representation to 2.3 MB. Although it is over an order of magnitude slower than typical DES systems, we believe it is fast enough for application to some DRM problems.
Bed wetting in school children of Karachi.

OBJECTIVES
To estimate the frequency of primary nocturnal enuresis (PNE) in Pakistani children and to examine the factors associated with it.


METHODS
A randomly selected cross-sectional study was conducted in five elementary schools, one in each of five districts of Karachi. The parents of 5000 children age between 3-13 years were asked to complete a questionnaire which included items about the frequency of daytime wetting and nocturnal enuresis, family history, urinary tract infection, parents and child's own concern about this problem and acquisition of treatments.


RESULTS
Over all corrected response rate to the questionnaire was 69% (3395). Enuresis was present in 9.1% (308). There were 166 (53.9%) boys and 142 (46%) girls with a median age of 7 years. Only 54% (166) children sought help for their problem of which 26% consulted doctors, 16% visited homeopaths while 11% used hakeems and home remedies. Of the bed wetters, 30% were wet every night, 30% for more than three nights a week and 40% for less than three nights every week. Parents of 68.5% (211) children reported concern for the problem while 69.8% (215) children were also anxious about their enuresis. Among the concerned children group, 22% parents were not concerned about their child's problem. Family history of enuresis was present in 25.6% (79) children.


CONCLUSION
The frequency of enuresis among the school going children in Karachi is 9.1% and is similar to that reported in European countries and other Asian countries including Korea and Taiwan. Enuresis causes concern to both parents and children, but only a small percentage of parents seek medical help for this problem.
Force based manipulation of Jenga blocks

Our goal is to copy human dexterity of manipulation with force feeling to robot manipulation. We adopt Jenga game as our first target task. This paper describes our strategic implementation how robot removes blocks from Jenga tower. In this paper, we make Jenga kinematics model. First we show kinematics model of stable Jenga tower. Another kinematics model is of transition period of removing block. Using these kinematics models, robot manipulator chooses the most safe block to remove. But of course, there exist difference of acting force between ideal model and actual Jenga tower. So the robot judges the acting force against ideal one whether the block can be removed or not. When it is judged not to remove, the robot changes to next candidate to remove. According this force based manipulation strategy, the robot has achieved to remove more than twelve blocks form Jenga block tower. During competition with human, the robot can remove a block after more than twenty blocks are removed.
Comprehensive Knowledge of HIV among Women in Rural Mozambique: Development and Validation of the HIV Knowledge 27 Scale

BACKGROUND
The relationship between HIV knowledge and HIV-related behaviors in settings like Mozambique has been limited by a lack of rigorously validated measures.


METHODS
A convenience sample of women seeking prenatal care at two clinics were administered an adapted, orally-administered, 27 item HIV-knowledge scale, the HK-27. Validation analyses were stratified by survey language (Portuguese and Echuabo). Kuder-Richardson (KR-20) coefficients estimated internal reliability. Construct validity was assessed with bivariate associations between HK-27 scores (% correct) and selected participant characteristics. The association between knowledge, self-reported HIV testing, and HIV infection were evaluated with multivariable logistic regression.


RESULTS
Participants (N = 348) had a median age of 24; 188 spoke Portuguese, and 160 spoke Echuabo. Mean HK-27 scores were higher for Portuguese-speaking participants than Echuabo-speaking participants (68% correct vs. 42%, p<0.001). Internal reliability was strong (KR-20>0.8) for scales in both languages. Higher HK-27 scores were significantly (p≤0.05) correlated with more education, more media items in the home, a history of HIV testing, and participant work outside of the home for women of both languages. HK-27 scores were independently associated with completion of HIV testing in multivariable analysis (per 1% correct: aOR:1.02, 95%CI:0.01-0.03, p = 0.01), but not with HIV infection.


CONCLUSIONS
HK-27 is a reliable and valid measure of HIV knowledge among Portuguese and Echuabo-speaking Mozambican women. The HK-27 demonstrated significant knowledge deficits among women in the study, and higher scores were associated with higher HIV testing probability. Future studies should evaluate the role of the HK-27 in longitudinal studies and in other populations.
Comparison of outcome and interventional complication rate in patients with acute stroke treated with mechanical thrombectomy with and without bridging thrombolysis.

BACKGROUND
No randomized trial has investigated the effect of mechanical thrombectomy (MT) alone in patients with acute stroke. There are conflicting results as to whether prior intravenous thrombolysis (IVT) facilitates subsequent MT, and data in patients treated with MT alone owing to contraindications to IVT are limited.


OBJECTIVE
To compare consecutive patients treated with MT alone or with preceding IVT in a large tertiary neurointerventional center, with special emphasis on contraindications to IVT.


METHODS
Retrospective analysis of 283 consecutive patients with acute ischemic stroke treated with MT in a tertiary neurovascular center over 14 months. Data on characteristics of periprocedural times, recanalization rate, complications, and long-term functional outcome were collected prospectively.


RESULTS
Information on prior IVT and functional outcome was available in 250 patients. Mean (SD) follow-up period was 5.7 (5.1) months and 105 (42%) patients received both IVT and MT. No significant differences were found in successful recanalization rates (Thrombolysis in Cerebral Infarction (TICI) 2b/3, 73.8% vs 73.1, p=0.952), complication rates, and long-term favorable outcome (modified Rankin Scale 0-2, 35.2% vs 40%, p=0.444) between patients receiving MT plus IVT and those receiving MT alone. A favorable outcome in patients directly treated with MT alone who were eligible for IVT was achieved in 48.2%. Thrombectomy was safe and resulted in a favorable outcome in 32% of patients with absolute contraindications to IVT.


CONCLUSIONS
Preceding use of IVT was not an independent predictor of favorable outcome in patients with acute stroke treated with MT and complication rates did not differ whether or not IVT was used. MT is safe and achieved a favorable outcome in one-third of patients with stroke ineligible for IVT.
Transmission of Extensively Drug-Resistant Tuberculosis in South Africa.

BACKGROUND
Drug-resistant tuberculosis threatens recent gains in the treatment of tuberculosis and human immunodeficiency virus (HIV) infection worldwide. A widespread epidemic of extensively drug-resistant (XDR) tuberculosis is occurring in South Africa, where cases have increased substantially since 2002. The factors driving this rapid increase have not been fully elucidated, but such knowledge is needed to guide public health interventions.


METHODS
We conducted a prospective study involving 404 participants in KwaZulu-Natal Province, South Africa, with a diagnosis of XDR tuberculosis between 2011 and 2014. Interviews and medical-record reviews were used to elicit information on the participants' history of tuberculosis and HIV infection, hospitalizations, and social networks. Mycobacterium tuberculosis isolates underwent insertion sequence (IS)6110 restriction-fragment-length polymorphism analysis, targeted gene sequencing, and whole-genome sequencing. We used clinical and genotypic case definitions to calculate the proportion of cases of XDR tuberculosis that were due to inadequate treatment of multidrug-resistant (MDR) tuberculosis (i.e., acquired resistance) versus those that were due to transmission (i.e., transmitted resistance). We used social-network analysis to identify community and hospital locations of transmission.


RESULTS
Of the 404 participants, 311 (77%) had HIV infection; the median CD4+ count was 340 cells per cubic millimeter (interquartile range, 117 to 431). A total of 280 participants (69%) had never received treatment for MDR tuberculosis. Genotypic analysis in 386 participants revealed that 323 (84%) belonged to 1 of 31 clusters. Clusters ranged from 2 to 14 participants, except for 1 large cluster of 212 participants (55%) with a LAM4/KZN strain. Person-to-person or hospital-based epidemiologic links were identified in 123 of 404 participants (30%).


CONCLUSIONS
The majority of cases of XDR tuberculosis in KwaZulu-Natal, South Africa, an area with a high tuberculosis burden, were probably due to transmission rather than to inadequate treatment of MDR tuberculosis. These data suggest that control of the epidemic of drug-resistant tuberculosis requires an increased focus on interrupting transmission. (Funded by the National Institute of Allergy and Infectious Diseases and others.).
Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes

AIMS
Sodium-glucose co-transporter 2 (SGLT2) reabsorbs glucose and sodium in the renal proximal tubule. Dapagliflozin, an SGLT2 inhibitor, targets hyperglycaemia in type 2 diabetes by increasing renal glucose excretion. To investigate whether the parallel occurring sodium loss would have diuretic-like physiologic effects, we compared dapagliflozin and hydrochlorothiazide (HCTZ) effects on 24-h blood pressure (BP), body weight, plasma volume and glomerular filtration rate (GFR).


METHODS
In this randomized, placebo-controlled, double-blind trial, 75 subjects with type 2 diabetes were assigned placebo, dapagliflozin 10 mg/day, or HCTZ 25 mg/day. Changes from baseline BP, body weight, plasma volume and GFR were assessed after 12 weeks of treatment.


RESULTS
Subjects' mean age was 56 years, type 2 diabetes mellitus (T2DM) duration 6.3 years, and haemoglobin A1c (HbA1c) 7.5%. Treatment with placebo, dapagliflozin or HCTZ resulted in changes from baseline in 24-h ambulatory mean systolic blood pressure (SBP) of -0.9 (95%CI -4.2, +2.4), -3.3 (95%CI -6.8, +0.2), and -6.6 (95%CI -9.9, -3.2) mmHg, respectively at week 12, adjusted for baseline SBP. Body weight decreased with dapagliflozin and HCTZ. In a sub-study plasma volume appeared to decrease with dapagliflozin but did not change with placebo or HCTZ treatment. Dapagliflozin induced a greater reduction in GFR (-10.8%; 95%CI -14.6, -6.7) relative to placebo (-2.9%; 95% CI -6.9, +1.2) or HCTZ (-3.4%; 95%CI -7.3, +0.6).


CONCLUSIONS
Dapagliflozin-induced SGLT2 inhibition for 12 weeks is associated with reductions in 24-h BP, body weight, GFR and possibly plasma volume. Cumulatively, these effects suggest that dapagliflozin may have a diuretic-like capacity to lower BP in addition to beneficial effects on glycaemic control.
Improving the Writing Performance of Young Struggling Writers: Theoretical and Programmatic Research From the Center on Accelerating Student Learning

The number of children with a writing disability is not known. However, data from the National Assessment of Educational Progress reveal that many students in the United States do not write well. In both 1998 and 2002, the majority of 4th-, 8th-, and 12th-grade students who completed this assessment demonstrated only partial mastery of the writing skills and knowledge needed at their respective grade levels (Greenwald, Persky, Cambell, & Mazzeo, 1999; Persky, Daane, & Jin, 2003). Writing problems are also common among children with special needs, as students with behavioral disorders, attention-deficit/ hyperactivity disorders (ADHD), learning disabilities, and speech and language difficulties experience considerable difficulty learning to write (e.g., Gilliam & Johnston, 1992; Nelson, Benner, Lane, & Smith, 2004; Newcomer & Barenbaum, 1991; Resta & Eliot, 1994). Unfortunately, current educational reform, as reflected in the No Child Left Behind Act (NCLB), places little emphasis on writing. In our opinion, this was an unfortunate oversight, as writing is critical to school success. It is the primary means by which students demonstrate their knowledge in school (Graham & Harris, 2004), but even more important, it provides a flexible tool for gathering, remembering, and sharing subject-matter knowledge as well as an instrument for helping children explore, organize, and refine their ideas about a specific subject. Although writing is neglected by NCLB, other voices, such as the College Board, an organization of more than 4,300 colleges, warned that students and society will be shortImproving the Writing Performance of Young Struggling Writers:
Asset Location for Retirement Savers

This paper uses data on actual returns on taxable bonds, tax-exempt bonds, and a small sample of equity mutual funds over the 1962-1998 period to compare two asset location strategies for retirement savers who invest in equities through equity mutual funds. The first strategy, ‘defer stocks first,’ gives priority to holding equity mutual funds in a saver’s tax-deferred account, while the second strategy, ‘defer bonds first,’ gives priority to holding fixed-income investments in the tax-deferred account. We consider high-income taxable individual investors who saved in each year and invested in one of the actively-managed funds in our sample. Over the thirtyseven year span that we consider, such investors would have accumulated a larger stock of wealth if they had held their actively-managed equity mutual fund in their tax-deferred account than if they had held the fund in a conventional taxable form. The explanation for this apparent contradiction of the often-stated ‘bonds in the tax-deferred account’ prescription has two parts. First, many equity mutual funds impose substantial tax burdens on their investors. This raises the effective tax rate on investing in equities through mutual funds rather than in a buy-and-hold personal portfolio. Second, taxable investors who wish to hold fixed income assets can do so either by holding tax-exempt bonds or by holding taxable bonds. The interest rate differential between taxable and tax-exempt bonds suggests that the effective tax rate on fixed income investments may be lower than the statutory tax rate for high-income investors. We thank Olivia Lau and Svetla Tzenova for assistance with data collection, William Gale, Davide Lombardo, Sita Nataraj, and Paul Samuelson for helpful comments on an earlier draft, and the National Science Foundation (Poterba) for research support.
How Can Activity-Based Costing Methodology Be Performed as a Powerful Tool to Calculate Costs and Secure Appropriate Patient Care?

Previous studies have shown the advantages of using activity-based costing (ABC) methodology in the health care industry. The potential values of ABC methodology in health care are derived from the more accurate cost calculation compared to the traditional step-down costing, and the potentials to evaluate quality or effectiveness of health care based on health care activities. This project used ABC methodology to profile the cost structure of inpatients with surgical procedures at the Department of Colorectal Surgery in a public teaching hospital, and to identify the missing or inappropriate clinical procedures. We found that ABC methodology was able to accurately calculate costs and to identify several missing pre- and post-surgical nursing education activities in the course of treatment.