LLukas22/scidocs huggingface dataset:
Dietary changes in migrant adolescents with increasing length of stay in Australia and associated risk of wheeze – a retrospective, cross sectional study

BACKGROUND
Recent studies have reported that asthma prevalence increases on migration to Australia. We hypothesised that changes in dietary intake contribute to this phenomenon. The aim of this study was to assess dietary intake in relation to migration status, length of stay in Australia and the association with self-reported wheeze.


METHODS
Students (n = 144) in a multicultural high school in Western Sydney completed the asthma symptoms ISAAC video questionnaire (AVQ3.0), spirometry and allergy skin prick tests. A dietitian administered a'Food Frequency' and 'Food Habits' questionnaire and a dietary history interview.


RESULTS
Students who spoke a language other than English, consumed a traditional or mixed dietary pattern, with lower consumption of saturated fat, compared to students who spoke English only. Saturated fat intake increased and fibre intake decreased with length of time in Australia. Intake of foods high in saturated or trans fatty acids were positively associated with length of stay in Australia. No associations between nutrient intake or whole food intake and self-reported wheeze were observed.


CONCLUSION
As time progressed, dietary intake of immigrant children changed. While this was not associated with the development of wheeze in the students in this cohort, these changes are likely to have negative health consequences.
Quality of Life After Isolated Limb Infusion for In-Transit Melanoma of the Extremity

Isolated limb infusion (ILI) has been associated with persistent edema, numbness, pain, and functional impairment of the treated limb. However, health-related quality of life (HRQOL) has not yet been assessed using a validated questionnaire. Functional Assessment of Cancer Therapy-Melanoma (FACT-M) questionnaires were collected from subjects enrolled a phase I ILI trial with temozolomide at baseline and 2, 6 weeks, and 3 months post-ILI. Of 28 enrolled patients, 19 patients received maximum tolerated dose of temozolomide and are included in the HRQOL analysis. Clinical and operative variables and treatment response data also were collected. HRQOL scores showed a trend of improvement from baseline through 3-months post-ILI as measured by FACT-M and the melanoma surgery scores. There were no differences in HRQOL when patients were stratified by disease burden, clinical toxicity level, and 3-month disease response. Additionally, fewer patients complained of pain, numbness, and swelling of the affected limb at 3 months post-ILI compared to baseline, and also these symptoms were improved at the immediate postoperative visit compared with baseline. Despite the known morbidity of ILI, we have demonstrated with a validated HRQOL questionnaire that HRQOL is not adversely impacted at therapeutic doses of temozolomide delivered intra-arterially from baseline through 3 months posttreatment. Patient centered-outcomes should be evaluated as a standard part of all future regional therapy trials using standardized melanoma-specific HRQOL questionnaires to more completely evaluate the utility of this type of treatment strategy.
Preheated composite resin used as a luting agent for indirect restorations: effects on bond strength and resin-dentin interfaces.

PURPOSE
The aim of this study was to evaluate the effect of preheating composite resins used as luting agents for indirect restorations on microtensile bond strength (µTBS) and adhesive interfaces.


MATERIAL AND METHODS
Fifty sound extracted third molars were used. Ten experimental groups were formed with three different luting agents: one resin cement (RelyX ARC) and two composite resins (Venus and Z250 XT). The composite resins were tested both at room temperature and when preheated to 64°C. Restoration depth was tested using 2 or 4 mm-height indirect composite resin restorations, previously made on cylindrical molds. Adhesive and luting procedures were done under simulated pulpal pressure. After luting, the teeth were sectioned into beams with a cross-sectional area of 1 mm2 at the bonded interface, and tested in tension at 0.5 mm/min. The characteristics of the adhesive interfaces were observed under scanning electron microscopy (SEM). The µTBS data were analyzed using ANOVA and the Tukey test (α = 0.05).


RESULTS
When luting 2 mm restorations, the composite resin Z250 XT, preheated or at room temperature, achieved significantly higher µTBS than did RelyX ARC. At this depth, Venus did not differ from the resin cement, and with the 4 mm restorations, only preheated Venus presented significantly higher µTBS than RelyX ARC. Preheating the composite resin resulted in thinner luting interfaces, with a more intimate interaction between luting agent and adhesive layer.


CONCLUSION
Preheating composite resin for luting procedures may not improve µTBS, although it could be used to reduce material viscosity and improve restoration setting.
Heavy metals contamination in water and sediments of an urban river in a developing country

Water and sediment samples were collected from 20 location of the Buriganga river of Bangladesh during Summer and Winter 2009 to determine the spatial distribution, seasonal and temporal variation of different heavy metal contents. Sequential extraction procedure was employed in sediment samples for the geochemical partitioning of the metals. Total trace metal content in water and sediment samples were analyzed and compared with different standard and reference values. Concentration of total chromium, lead, cadmium, zinc, copper, nickel, cobalt and arsenic in water samples were greatly exceeded the toxicity reference values in both season. Concentration of chromium, lead, copper and nickel in sediment samples were mostly higher than that of severe effect level values, at which the sediment is considered heavily polluted. On average 72 % chromium, 92 % lead, 88 % zinc, 73 % copper, 63 % nickel and 68 % of total cobalt were associated with the first three labile sequential extraction phases, which portion is readily bioavailable and might be associated with frequent negative biological effects. Enrichment factor values demonstrated that the lead, cadmium, zinc, chromium and copper in most of the sediment samples were enriched sever to very severely. The pollution load index value for the total area was as high as 21.1 in Summer and 24.6 in Winter season; while values above one indicates progressive deterioration of the sites and estuarine quality. The extent of heavy metals pollution in the Buriganga river system implies that the condition is much frightening and may severely affect the aquatic ecology of the river.
Realtime Computer Vision with OpenCV

Mobile computer-vision technology will soon become as ubiquitous as touch interfaces.
Dogs Can Be Successfully Trained to Alert to Hypoglycemia Samples from Patients with Type 1 Diabetes

INTRODUCTION
Hypoglycemia (Hypo) is the most common side effect of insulin therapy in people with type 1 diabetes (T1D). Over time, patients with T1D become unaware of signs and symptoms of Hypo. Hypo unawareness leads to morbidity and mortality. Diabetes alert dogs (DADs) represent a unique way to help patients with Hypo unawareness. Our group has previously presented data in abstract form which demonstrates the sensitivity and specificity of DADS. The purpose of our current study is to expand evaluation of DAD sensitivity and specificity using a method that reduces the possibility of trainer bias.


METHODS
We evaluated 6 dogs aging 1-10 years old who had received an average of 6 months of training for Hypo alert using positive training methods. Perspiration samples were collected from patients during Hypo (BG 46-65 mg/dL) and normoglycemia (BG 85-136 mg/dl) and were used in training. These samples were placed in glass vials which were then placed into 7 steel cans (1 Hypo, 2 normal, 4 blank) randomly placed by roll of a dice. The dogs alerted by either sitting in front of, or pushing, the can containing the Hypo sample. Dogs were rewarded for appropriate recognition of the Hypo samples using a food treat via a remote control dispenser. The results were videotaped and statistically evaluated for sensitivity (proportion of lows correctly alerted, "true positive rate") and specificity (proportion of blanks + normal samples not alerted, "true negative rate") calculated after pooling data across all trials for all dogs.


RESULTS
All DADs displayed statistically significant (p value <0.05) greater sensitivity (min 50.0%-max 87.5%) to detect the Hypo sample than the expected random correct alert of 14%. Specificity ranged from a min of 89.6% to a max of 97.9% (expected rate is not defined in this scenario).


CONCLUSIONS
Our results suggest that properly trained DADs can successfully recognize and alert to Hypo in an in vitro setting using smell alone.
Wall slip and flow of concentrated hard-sphere colloidal suspensions

We present a comprehensive study of the slip and flow of concentrated colloidal suspensions using cone-plate rheometry and simultaneous confocal imaging. In the colloidal glass regime, for smooth, non-stick walls, the solid nature of the suspension causes a transition in the rheology from Herschel-Bulkley (HB) bulk flow behavior at large stress to a Bingham-like slip behavior at low stress, which is suppressed for sufficient colloid-wall attraction or colloid-scale wall roughness. Visualization shows how the slip-shear transition depends on gap size and the boundary conditions at both walls and that partial slip persist well above the yield stress. A phenomenological model, incorporating the Bingham slip law and HB bulk flow, fully accounts for the behavior. Microscopically, the Bingham law is related to a thin (sub-colloidal) lubrication layer at the wall, giving rise to a characteristic dependence of slip parameters on particle size and concentration. We relate this to the suspension's osmotic pressure and yield stress and also analyze the influence of van der Waals interaction. For the largest concentrations, we observe non-uniform flow around the yield stress, in line with recent work on bulk shear-banding of concentrated pastes. We also describe residual slip in concentrated liquid suspensions, where the vanishing yield stress causes coexistence of (weak) slip and bulk shear flow for all measured rates.
Secure multi-server-aided data deduplication in cloud computing

Cloud computing enables on-demand and ubiquitous access to a centralized pool of configurable resources such as networks, applications, and services. This makes that huge of enterprises and individual users outsource their data into the cloud server. As a result, the data volume in the cloud server is growing extremely fast. How to efficiently manage the ever-increasing datum is a new security challenge in cloud computing. Recently, secure deduplication techniques have attracted considerable interests in the both academic and industrial communities. It can not only provide the optimal usage of the storage and network bandwidth resources of cloud storage providers, but also reduce the storage cost of users. Although convergent encryption has been extensively adopted for secure deduplication, it inevitably suffers from the off-line brute-force dictionary attacks since the message usually can be predictable in practice. In order to address the above weakness, the notion of DupLESS was proposed in which the user can generate the convergent key with the help of a key server. We argue that the DupLESS does not work when the key server is corrupted by the cloud server. In this paper, we propose a newmulti-server-aided deduplication scheme based on the threshold blind signature, which can effectively resist the collusion attack between the cloud server and multiple key servers. Furthermore, we prove that our construction can achieve the desired security properties. © 2015 Elsevier B.V. All rights reserved.
Combined BRAF and MEK inhibition versus BRAF inhibition alone in melanoma.

BACKGROUND
Combined BRAF and MEK inhibition, as compared with BRAF inhibition alone, delays the emergence of resistance and reduces toxic effects in patients who have melanoma with BRAF V600E or V600K mutations.


METHODS
In this phase 3 trial, we randomly assigned 423 previously untreated patients who had unresectable stage IIIC or stage IV melanoma with a BRAF V600E or V600K mutation to receive a combination of dabrafenib (150 mg orally twice daily) and trametinib (2 mg orally once daily) or dabrafenib and placebo. The primary end point was progression-free survival. Secondary end points included overall survival, response rate, response duration, and safety. A preplanned interim overall survival analysis was conducted.


RESULTS
The median progression-free survival was 9.3 months in the dabrafenib-trametinib group and 8.8 months in the dabrafenib-only group (hazard ratio for progression or death in the dabrafenib-trametinib group, 0.75; 95% confidence interval [CI], 0.57 to 0.99; P=0.03). The overall response rate was 67% in the dabrafenib-trametinib group and 51% in the dabrafenib-only group (P=0.002). At 6 months, the interim overall survival rate was 93% with dabrafenib-trametinib and 85% with dabrafenib alone (hazard ratio for death, 0.63; 95% CI, 0.42 to 0.94; P=0.02). However, a specified efficacy-stopping boundary (two-sided P=0.00028) was not crossed. Rates of adverse events were similar in the two groups, although more dose modifications occurred in the dabrafenib-trametinib group. The rate of cutaneous squamous-cell carcinoma was lower in the dabrafenib-trametinib group than in the dabrafenib-only group (2% vs. 9%), whereas pyrexia occurred in more patients (51% vs. 28%) and was more often severe (grade 3, 6% vs. 2%) in the dabrafenib-trametinib group.


CONCLUSIONS
A combination of dabrafenib and trametinib, as compared with dabrafenib alone, improved the rate of progression-free survival in previously untreated patients who had metastatic melanoma with BRAF V600E or V600K mutations. (Funded by GlaxoSmithKline; Clinical Trials.gov number, NCT01584648.).
A comparative analysis of mammalian genomics: Prokaryote and eukaroyte perspectives

Genomes of all extant living organisms, and not just mammalian species, share much genetic material as well as genomic structure and organization in common with each other. As a result, much of the current insights into evolutionary processes and mechanisms come from the analysis of the wealth of available molecular data...
A multi-agent optimization algorithm for resource constrained project scheduling problem

In this paper, a multi-agent optimization algorithm (MAOA) is proposed for solving the resourceconstrained project scheduling problem (RCPSP). In the MAOA, multiple agents work in a grouped environment where each agent represents a feasible solution. The evolution of agents is achieved by using four main elements in the MAOA, including social behavior, autonomous behavior, self-learning, and environment adjustment. The social behavior includes the global one and the local one for performing exploration. Through the global social behavior, the leader agent in every group is guided by the global best leader. Through the local social behavior, each agent is guided by its own leader agent. Through the autonomous behavior, each agent exploits its own neighborhood. Through the self-learning, the best agent performs an intensified search to further exploit the promising region. Meanwhile, some agents perform migration among groups to adjust the environment dynamically for information sharing. The implementation of the MAOA for solving the RCPSP is presented in detail, and the effect of key parameters of the MAOA is investigated based on the Taguchi method of design of experiment. Numerical testing results are provided by using three sets of benchmarking instances. The comparisons to the existing algorithms demonstrate the effectiveness of the proposed MAOA for solving the RCPSP. 2015 Elsevier Ltd. All rights reserved.
Persistence in youth unemployment

This paper examines the degree of persistence of youth unemployment (total, male and female) in twenty-four countries by using two alternative measures: the AR coefficient and the fractional differencing parameter, based on shortand long-memory processes respectively. The evidence suggests that persistence is particularly high in Japan and some EU countries such as Spain, Portugal, Ireland and Finland, where appropriate policy actions are of the essence. Specifically, active labour market policies are necessary to prevent short-term unemployment from becoming structural (long-term). JEL-Code: C220, J640.
Scan-time reduction using noise-matched images in 2- and 3-dimensional bismuth germanate PET/CT: clinical study in head and neck cancer.

UNLABELLED
We quantitatively and qualitatively investigated 2-dimensional (2D) and 3-dimensional (3D) imaging with scan-time reduction in 14 patients with 17 lesions, who had known or suspected head and neck cancer, using a bismuth germanate (BGO) crystal based PET/CT scanner with noise-matched images.


METHODS
A 2D and 3D acquisition protocol using scan-time reduction on an axial single field of view resulted in a 2D 4-, 3D 4-, 3D 3-, 2D 3-, 2D 2-, and 3D 2-min scan sequence to minimize redistribution and decay bias. Tumor maximum standardized uptake values (SUVmax) and tumor mean standardized uptake values (SUV(mean)) were recorded, and two observers in consensus investigated lesion conspicuity between 2D and 3D paired 4-, 3-, and 2-min noise-matched images.


RESULTS
We found some minor advantages quantitatively in favor of 2D scanning, with higher mean SUVmax, and qualitatively in favor of 3D scanning, with lesion conspicuity preference. In our cohort, no great advantage or disadvantage to using either acquisition mode was observed, and all lesions were seen irrespective of acquisition mode and scan time.


CONCLUSION
In head and neck cancer patients, we can recommend a scan-time reduction from 4 to 3 min/bed position in 2D acquisitions with a BGO-based PET/CT scanner, using our imaging protocol and reconstruction defaults.
A case report of a complete degloving injury of the penile skin

INTRODUCTION
Male genital degloving injuries are unusual and rarely caused by animal bite. Usually patients attend health care immediately if bitten in the genital area. Prophylactic antibiotics is routinely used (Gomes et al., 2000). A penile degloving usually begins just proximal of the coronal line and progress down to the base of the shaft. Deep erectile tissue and the spermatic cord are seldom damaged and the endogenous skin of glans usually survives (Brown and Fryer, 1957; Morey et al., 2004; Finical and Arnold, 1999).


PRESENTATION OF CASE
A heavily smoking man with a previous history of bladder cancer presented himself to the emergency department 24h after a dog bite degloved his penis. The avulsed skin was necrotic and subsequently excised. Antibiotic treatment was started. A bacterial swab was found positive for canine oral flora. The skin defect was closed using a 1:1 meshed split thickness skin graft from the inner thigh. Smoking cessation was encouraged. At the three month follow up the patient expressed satisfaction with both cosmetic and functional result and was now non-smoking.


DISCUSSION
Several approaches to reconstruct penile skin exist. Split thickness skin graft has been lifted as a preferable alternative (Brown and Fryer, 1957; Finical and Arnold, 1999; Paraskevas et al., 2003) [5]. In this case, the avulsed skin was necrotic and could not be used. A 1:1 meshed split-thickness graft was chosen with excellent results.


CONCLUSION
1:1mesh of the graft can be recommended for easy attachment with a good functional and esthetical result. The potential risk of losing intimacy appearance or having to go through repeated procedures in the genital area motivated smoking cessation for this patient.
Concurrent validity of questions on arm, shoulder and neck symptoms of the RSI QuickScan.

PURPOSE
The objective was to determine the concurrent validity of questions on arm, shoulder and neck symptoms of an Internet-based questionnaire. In addition, the inter-observer reliability of physical examinations by occupational physicians was investigated.


METHODS
A total of 160 employees of a Dutch occupational health service were approached, of which 106 participated. Right after the assessment of arm, shoulder and neck symptoms using a self-administered questionnaire, each participant was examined by two occupational physicians. The presence of symptoms in the past 7 days was compared to the physical examinations. The participation of two occupational physicians allowed us to study also the inter-observer reliability.


RESULTS
Overall, the concurrent validity of the symptom questions of the questionnaire can be defined as poor to moderate with κ values between 0.16 and 0.53. Detecting the presence of symptoms (p(pos)) could be considered as moderately valid with values below 0.60, but the p(neg) shows that the concurrent validity for detecting the absence of arm, shoulder or neck symptoms can be considered sufficient with values above 0.69. The agreement between occupational physicians can, with a few exceptions, be considered as moderate with κ values below 0.60. The agreement was sufficient for detecting the absence of symptoms (p(neg) > 0.7).


CONCLUSIONS
The agreement between the symptom questions of the questionnaire and physical examinations of occupational physicians can be considered as poor to moderate. The results are comparable to what is generally reported in the literature. Future studies should be aimed at gaining more fundamental knowledge about the possible conceptual differences between self-reported symptoms and symptoms assessed using physical examinations. Moreover, it is advisable to improve the inter-observer reliability of physical examinations as applied in the present study.
Congenital nephrotic syndrome: A novel phenotype of type I carbohydrate-deficient glycoprotein syndrome

Type I carbohydrate-deficient glycoprotein (CDG) syndrome is a genetic multisystem disorder generally without overt renal problems. We report a neonate with neurological abnormalities and congenital nephrotic syndrome of diffuse mesangial sclerosis type. Serum transferrin isoelectric focusing showed the typical abnormalities of type I CDG syndrome. Normal transferrin focusing findings in other patients with similar renal problems excluded the possibility of a secondary biochemical phenomenon. The diagnosis of type I CDG syndrome was confirmed by demonstration of a deficiency of phosphomannomutase. No evidence of pontocerebellar atrophy was found in imaging or at autopsy. We conclude that congenital nephrotic syndrome may occur in type I CDG syndrome, and that this diagnosis should be considered in patients with congenital nephrotic syndrome. Absence of pontocerebellar atrophy does not exclude the diagnosis of type I CDG syndrome.