LLukas22/scidocs huggingface dataset:
Pregnancy Induced Hypertension and Associated Factors among Pregnant Women in Karamara Hospital, Jijiga, Eastern Ethiopia, 2015

Background: Pregnancy induced hypertension (PIH) is a significance rise of blood pressure during pregnancy, occurring after 20 weeks. It includes gestational hypertension, mild pre-eclampsia , sever pre-eclampsia and eclampsia. So more, women with PIH disorders may progress from mild diseases to more serious conditions. This study assessed pregnancy induced hypertension and associated factors among pregnant women. Methods: A hospital based crosssectional study design was conducted in Karamara hospital, Jijiga town among 408 pregnant. Systematic random sampling was employed. The data was collected using pretested semi-structured questionnaire and analyzed using SPSS Version 20. Results: The prevalence of pregnancy induced hypertension was 19.1% in Karamara hospital. Maternal education (AOR=2.5, 95% CI%=1.2-5.3), age (AOR=2.73, 95% CI=1.31-5.7), previous history of preeclampsia (AOR=19.3, 95% CI%=5.2-72.1) and family history of preeclampsia (AOR=7.2, 95% CI%=2.9-17.8) were identified as predictor factors for occurrence of pregnancy induced hypertension. Conclusion and recommendations: One out of five women developed pregnancy induced hypertension in Karamara referral Hospital, Jigjiga Ethiopia. This is figure is very high compared to studies conducted in Ethiopia. Socio-demographic factors like age less than 25 years, lack formal education, previous history of PIH and family history of PIH were independent predictors of development of pregnancy induced hypertension. Hence, this study suggests that early detection and management of mothers with PIH should be mandatory as part of focused antenatal care. Lastly, this study suggests that further studies should be conducted to assess lifestyle and dietary factors, using analytical study designs. *Corresponding author: Liyew Mekonen, Department of Public Health, College of Medicine and Health Sciences, Reproductive Health and Nutrition Unit, Jigjiga University, Ethiopia, Tel: +251921626447; Fax: +251257755947; E-mail: liy900@gmail.com Received: April 18, 2018; Accepted: May 25, 2018; Published: Jun 01, 2018 Citation: Mekonen L, Shiferaw Z, Wubshet E, Haile S (2018) Pregnancy Induced Hypertension and Associated Factors among Pregnant Women in Karamara Hospital, Jijiga, Eastern Ethiopia, 2015. J Preg Child Health 5: 379. doi:10.4172/2376-127X.1000379 Copyright: © 2018 Mekonen L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Nifedipine plus candesartan combination increases blood pressure control regardless of race and improves the side effect profile: DISTINCT randomized trial results

OBJECTIVES
DISTINCT (reDefining Intervention with Studies Testing Innovative Nifedipine GITS - Candesartan Therapy) aimed to determine the dose-response and tolerability of nifedipine GITS and/or candesartan cilexetil therapy in participants with hypertension.


METHODS
In this 8-week, multinational, multicentre, randomized, double-blind, placebo-controlled study, adults with mean seated DBP of at least 95 to less than 110 mmHg received combination or monotherapy with nifedipine GITS (N) 20, 30 or 60 mg and candesartan cilexetil (C) 4, 8, 16 or 32 mg, or placebo. The primary endpoint, change in DBP from baseline to Week 8, was analysed using the response surface model (RSM); this analysis was repeated for mean seated SBP.


RESULTS
Overall, 1381 participants (mean baseline SBP/DBP: 156.5/99.6 mmHg) were randomized. Both N and C contributed independently to SBP/DBP reductions [P < 0.0001 (RSM)]. A positive dose-response was observed, with all combinations providing statistically better blood pressure (BP) reductions from baseline versus respective monotherapies (P < 0.05) and N60C32 achieving the greatest reduction [-23.8/-16.5 mmHg; P < 0.01 versus placebo (-5.3/-6.7 mmHg) and component monotherapies]. Even very low-dose (N20 and C4) therapy provided significant BP-lowering, and combination therapy was similarly effective in different racial groups. N/C combination demonstrated a lower incidence of vasodilatory adverse events than N monotherapy (18.3 versus 23.6%), including headache (5.5 versus 11.0%; P = 0.003, chi-square test) and peripheral oedema over time (3.6 versus 5.8%; n.s.).


CONCLUSION
N/C combination was effective in participants with hypertension and showed an improved side effect profile compared with N monotherapy.
Risky decision making assessed with the gambling task in adults with HIV.

Decision making was assessed using a laboratory gambling task in 67 adults with the Human Immunodeficiency Virus (HIV+) and in 19 HIV-seronegative (HIV-) control participants. Neurocognitive test performance across several domains was also analyzed to examine potential cognitive mechanisms of gambling task performance. As predicted, the HIV+ group performed worse on the gambling task, indicating greater risky decision making. Specifically, the HIV+ group selected more cards from the "risky" or disadvantageous deck that included relatively large payoffs but infrequent large penalties. The control group also selected such risky cards but quickly learned to avoid them. Exploratory analyses also indicated that in the HIV+ group, but not in the control group, gambling task performance was correlated with Stroop Interference performance and long delay free recall on the California Verbal Learning Test, suggesting the role of inhibitory processes and verbal memory in the poorer gambling task performance in HIV. These findings indicate the usefulness of the gambling task as a laboratory tool to examine risky decision making and cognition in the HIV population.
A Survey on the Edge Computing for the Internet of Things

The Internet of Things (IoT) now permeates our daily lives, providing important measurement and collection tools to inform our every decision. Millions of sensors and devices are continuously producing data and exchanging important messages via complex networks supporting machine-to-machine communications and monitoring and controlling critical smart-world infrastructures. As a strategy to mitigate the escalation in resource congestion, edge computing has emerged as a new paradigm to solve IoT and localized computing needs. Compared with the well-known cloud computing, edge computing will migrate data computation or storage to the network “edge,” near the end users. Thus, a number of computation nodes distributed across the network can offload the computational stress away from the centralized data center, and can significantly reduce the latency in message exchange. In addition, the distributed structure can balance network traffic and avoid the traffic peaks in IoT networks, reducing the transmission latency between edge/cloudlet servers and end users, as well as reducing response times for real-time IoT applications in comparison with traditional cloud services. Furthermore, by transferring computation and communication overhead from nodes with limited battery supply to nodes with significant power resources, the system can extend the lifetime of the individual nodes. In this paper, we conduct a comprehensive survey, analyzing how edge computing improves the performance of IoT networks. We categorize edge computing into different groups based on architecture, and study their performance by comparing network latency, bandwidth occupation, energy consumption, and overhead. In addition, we consider security issues in edge computing, evaluating the availability, integrity, and the confidentiality of security strategies of each group, and propose a framework for security evaluation of IoT networks with edge computing. Finally, we compare the performance of various IoT applications (smart city, smart grid, smart transportation, and so on) in edge computing and traditional cloud computing architectures.
Promoter insertion/deletion in the IRF5 gene is highly associated with susceptibility to systemic lupus erythematosus in distinct populations, but exerts a modest effect on gene expression in peripheral blood mononuclear cells.

OBJECTIVE
We examined the genetic association of the promoter insertion/deletion (indel) in IRF5 gene with systemic lupus erythematosus (SLE) in distinct populations and assessed its role in gene expression.


METHODS
Four IRF5 polymorphisms were genotyped in 1488 SLE patients and 1466 controls. Gene expression was analyzed by quantitative real-time PCR using RNA from peripheral blood mononuclear cells (PBMC).


RESULTS
The promoter indel and rs2070197 had independent genetic effects, which accounted for the association of rs2004640 and rs10954213. Gene expression analysis revealed that rs10954213 exerted the greatest influence on IRF5 transcript levels.


CONCLUSION
We corroborated the association of the promoter indel with SLE in 5 different populations and revealed that rs10954213 is the main single-nucleotide polymorphism responsible for altered IRF5 expression in PBMC.
Attribute Value Weighting in K-Modes Clustering

In this paper, the traditional k-modes clustering algorithm is extended by weighting attribute value matches in dissimilarity computation. The use of attribute value weighting technique makes it possible to generate clusters with stronger intra-similarities, and therefore achieve better clustering performance. Experimental results on real life datasets show that these value weighting based k-modes algorithms are superior to the standard k-modes algorithm with respect to clustering accuracy.
Filling the periorbital hollows with hyaluronic acid gel: Long-term review of outcomes and complications.

INTRODUCTION
Hyaluronic acid gel has been used for rejuvenation of the periorbital tissues since 2004. The in-office, nonsurgical procedural nature has resulted in the growing popularity of the use of fillers. The periorbital region poses unique challenges to the cosmetic surgeon. Malar edema, blue-gray dyschromia, and contour irregularities are well reported short-term complications. We present a long-term follow-up review of complications associated with periocular injection of hyaluronic acid gel fillers.


METHODS
Retrospective review of 147 patients with at least a 5-year follow-up period since the first injection. Five senior masked reviewers were asked to grade photographs of patients in comparison with preinjection photographs. Grading was based on a reference photographic key looking specifically at the presence and severity of malar edema, blue-gray dyschromia, and contour irregularity.


RESULTS
Malar edema (11%), blue-gray dyschromia (31.3%), and contour irregularities (30.5%) continue to be problems in longer term follow-up of patients. The vast majority (90%) of these complications were mild and required no intervention. There is no statistically significant difference in the mean volumes injected by severity grading of each measured complication.


CONCLUSION
Hyaluronic acid gel fillers of the periorbital region are well tolerated in our long-term follow-up experience. The vast majority of cases of malar edema, blue-gray dyschromia, and contour irregularities are mild and do not require intervention. Conservative treatment and tailored treatment approaches, in terms of volume and frequency of injections, may decrease the tendency of these adverse effects to occur.
Attitudes, knowledge, and actions with regard to organ donation among Hong Kong medical students.

OBJECTIVE
To study attitudes, knowledge, and actions of local medical students with regard to organ donation and self-perceived confidence and competence in approaching potential organ donors.


DESIGN
Cross-sectional questionnaire survey.


SETTING
Faculty of Medicine, The University of Hong Kong, Hong Kong.


PARTICIPANTS
Medical students, years 1-5.


MAIN OUTCOME MEASURES
Knowledge on various aspects of organ donation was assessed, and students' self-evaluated competence and confidence about counselling for organ donation was evaluated. Factors influencing attitudes and actions were determined.


RESULTS
The response rate was 94% (655/694). A majority (85%) had a 'positive' attitude, but only a small proportion (23%) had signed the organ donation card. Inconvenience and lack of knowledge about organ donor registration, and concerns about premature termination of medical treatment accounted for such discrepancies. Socio-cultural factors such as the traditional Chinese belief in preservation of an intact body after death, unease discussing death-related issues, and family objections to organ donation were significantly associated with a 'negative' attitude. Knowledge and action increased with medical education yet only a small proportion of medical students felt competent and confident in counselling patients on organ donation.


CONCLUSIONS
The medical curriculum should increase medical students' awareness of the organ shortage problem. The donor registration system should be made more convenient and public education is recommended to correct misconceptions.
Masked 3D conditional generative adversarial network for rock mesh generation

3D-GAN (Wu et al. in: Advances in Neural Information Processing Systems, pp. 82–90, 2016) has been introduced as a novel way to generate 3D models. In this paper, we propose a 3D-Masked-CGAN approach to apply in the generation of irregular 3D mesh geometry such as rocks. While there are many ways to generate 3D objects, the generation of irregular 3D models has its own peculiarity. To make a model realistic is extremely time-consuming and in high cost. In order to control the shape of generated 3D models, we extend 3D-GAN by adding conditional information into both the generator and discriminator. It is shown that that this model can generate 3D rock models with effective control over the shapes of generated models.
International differences in acute coronary syndrome patients' baseline characteristics, clinical management and outcomes in Western Europe: the EURHOBOP study.

OBJECTIVE
We aimed to describe current characteristics of patients admitted for acute coronary syndrome (ACS) in Western Europe and to analyse whether international in-hospital mortality variations are explained by differences in patients' baseline characteristics and in clinical management.


METHODS
We studied a population-based longitudinal cohort conducted in Finland, France, Germany, Greece, Portugal and Spain, and comprising 12 231 consecutive ACS patients admitted in 53 hospitals between 2008 and 2010. Baseline characteristics, clinical management and inhospital outcomes were recorded. Contextual effect of country on death was analysed through multilevel analysis.


RESULTS
Of all patients included, 8221 (67.2%) had NSTEMI (non-ST-elevation myocardial infarction), and 4010 (32.8%) had STEMI (ST-elevation myocardial infarction). Inhospital mortality ranged from 15.1% to 4.9% for German and Spanish STEMI patients, and from 6.8% to 1.9% for Finnish and French NSTEMI patients (p<0.001 for both). These international variations were explained by differences in patients' baseline characteristics (older patients more likely to have cardiogenic shock in Germany) and in clinical management, with differences in rates of thrombolysis (less performed in Germany) and primary percutaneous coronary intervention (high in Germany, low in Greece). A remaining contextual effect of country was identified after extensive adjustment.


CONCLUSIONS
Inhospital mortality rates of STEMI and NSTEMI patients were two to three times higher in Finland, Germany and Portugal than in Greece and Spain, with intermediate values for France. Differences in baseline characteristics and clinical management partly explain differences in outcome. Our data also suggest an impact of the healthcare system organisation.
Classification and comparison of architecture evolution reuse knowledge - a systematic review

Context: Architecture-centric software evolution (ACSE) enables changes in system’s structure and behaviour while maintaining a global view of the software to address evolution-centric trade-offs. The existing research and practices for ACSE primarily focus on design-time evolution and runtime adaptations to accommodate changing requirements in existing architectures. Objectives: We aim to identify, taxonomically classify and systematically compare the existing research focused on enabling or enhancing change reuse to support ACSE. Method: We conducted a systematic literature review of 32 qualitatively selected studies and taxonomically classified these studies based on solutions that enable (i) empirical acquisition and (ii) systematic application of architecture evolution reuse knowledge (AERK) to guide ACSE. Results: We identified six distinct research themes that support acquisition and application of AERK. We investigated (i) how evolution reuse knowledge is defined, classified and represented in the existing research to support ACSE and (ii) what are the existing methods, techniques and solutions to support empirical acquisition and systematic application of AERK. Conclusions: Change patterns (34% of selected studies) represent a predominant solution, followed by evolution styles (25%) and adaptation strategies and policies (22%) to enable application of reuse knowledge. Empirical methods for acquisition of reuse knowledge represent 19% including pattern discovery, configuration analysis, evolution and maintenance prediction techniques (approximately 6% each). A lack of focus on empirical acquisition of reuse knowledge suggests the need of solutions with architecture change mining as a complementary and integrated phase for architecture change execution. Copyright © 2014 John Wiley & Sons, Ltd. Received 13 May 2013; Revised 23 September 2013; Accepted 27 December 2013
Prognostic value of NT-proBNP in heart failure with preserved versus reduced EF.

OBJECTIVE
Plasma level of N-terminal-pro-brain natriuretic peptide (NT-proBNP) is a reliable prognostic factor in patients with heart failure (HF). However, it is unclear how differently the biomarker predicts adverse outcomes in HF with preserved EF (HFpEF) versus HF with reduced EF (HFrEF).


METHODS
From the Korean Heart Failure registry, a prospective multicentre cohort for consecutive patients who were hospitalised for acute HF syndrome, those with available NT-proBNP and LVEF measurements were extracted. Patients with LVEF ≥50% were categorised as the HFpEF group (N=528) and those with ≤40% as the HFrEF group (N=1142).


RESULTS
Patients with HFpEF had significantly lower NT-proBNP level than those with HFrEF (median 2723 vs 5644 ng/L, p<0.001). Event-free survival did not differ between the two groups either in terms of death from any cause (88.4% vs 86.9%; p=0.471) or the composite of death or HF readmission at 1 year (73.8% vs 70.6%; p=0.225). High levels of NT-proBNP were significantly associated with poor outcomes. However, the relationship was not different among the HFpEF and HFrEF groups (interaction p=0.956 for all-cause death; p=0.351 for the composite of all-cause death or HF hospitalisation).


CONCLUSIONS
Plasma level of NT-proBNP is the most powerful prognostic factor in both HFpEF and HFrEF. Although patients with HFpEF have lower NT-proBNP levels, the prognosis of a patient with HFpEF expected from a given NT-proBNP level is similar with his/her counterpart with HFrEF.
Patient satisfaction with postmastectomy breast reconstruction: a comparison of saline and silicone implants.

BACKGROUND
At a time when the safety and effectiveness of breast implants remains under close scrutiny, it is important to provide reliable and valid evidence regarding patient outcomes. In the setting of postmastectomy reconstruction, patient satisfaction and quality of life may be the most significant outcome variables when evaluating surgical success. The objective of the current study was to identify predictors of patient satisfaction with breast appearance, including implant type, in a large sample of women who underwent breast reconstruction surgery using implants.


METHODS
A multicenter, cross-sectional study design was used. A total of 672 women who had completed postmastectomy, implant-based reconstruction at 1 of 3 centers in North America were asked to complete the BREAST-Q (Reconstruction Module). Multivariate linear regression modeling was performed.


RESULTS
Completed questionnaire data were available for 482 of the 672 patients. In 176 women, silicone implants were placed and in 306, saline implants were used. The multivariate model confirmed that patients' satisfaction with their breasts was significantly higher in patients with silicone implants (P = .016). The receipt of postmastectomy radiotherapy was found to have a significant, negative effect on breast satisfaction (P<.000) in both silicone and saline implant recipients. In addition, for women who received either silicone or saline implants, satisfaction diminished over time (P = .017).


CONCLUSIONS
In the setting of postmastectomy reconstruction, patients who received silicone breast implants reported significantly higher satisfaction with the results of reconstruction than those who received saline implants. This information can be used to optimize shared medical decision-making by providing patients with realistic postoperative expectations.
Disability and back muscle fatigability changes following two therapeutic exercise interventions in participants with recurrent low back pain

BACKGROUND
The level of disability and endurance of back muscles have been investigated, but there is conflicting evidence following specific exercise interventions for participants with recurrent low back pain (LBP). The purpose of this study was to compare the level of disability and slope of median frequency (MF) of thoracic and lumbar erector spinae (ES) muscles following core stabilization exercise (CSE) and spinal flexibility exercise (SFE).


MATERIAL/METHODS
In total, 46 individuals participated in this study. There were 25 participants in the CSE intervention group (average age of 47.7 ± 8.9 years) and 21 participants in the SFE group (average age of 53.1 ± 9.0 years). Each group participated in the specific exercise intervention program for 4 weeks while maintaining their current activity and/or exercise levels. The Oswestry Disability Index (ODI) was used to measure the level of disability changes. The fatigability of the ES back muscles was measured by the slope of MF, using a modified Sorensen test.


RESULTS
The disability level decreased significantly following CSE intervention (t=2.23, p<0.05). However, there was no significant difference in muscle fatigability changes in the 4-week intervention period for either group.


CONCLUSIONS
The CSE intervention reduced disability level following the 4-week intervention period. Further studies are needed to investigate the effectiveness of specific back muscle exercises in longer intervention periods for back muscle fatigability.
Activism and political participation : roles, relationships and dependencies

A thesis submitted for the degree of Doctor of Philosophy to the 
Faculty of Humanities, University of Luton