LLukas22/scidocs huggingface dataset:
Weight gain, metabolic parameters, and the impact of race in aggressive inpatients randomized to double-blind clozapine, olanzapine or haloperidol

OBJECTIVE
The second-generation antipsychotic agents clozapine and olanzapine have been associated with weight gain and increased lipid and glucose blood levels. Since some of the neurotransmitters that are impaired in aggressive patients are involved in lipid/glucose metabolism, aggressive patients may represent a subgroup with a differential profile of adverse metabolic reactions to these medications. The goal of this study was to assess the effects of clozapine and olanzapine in comparison to the first-generation agent haloperidol on these metabolic parameters in aggressive patients with schizophrenia.


METHOD
110 inpatients with schizophrenia and a history of physical assaults were included in a randomized double-blind 12-week study. Fasting glucose, cholesterol and triglycerides were collected at baseline and at the end of the study. Ninety-three patients provided blood samples at baseline and at least at one point after randomization to clozapine (N=34), olanzapine (N=31) or haloperidol (N=28).


RESULTS
There were significant differences among the three medication groups in weight gain and in increases in blood lipids and glucose. Patients on haloperidol showed no increase on any of these parameters. Patients on olanzapine gained the most weight, but patients on clozapine had the greatest increases in cholesterol, triglyceride, and glucose. An effect of ethnicity was observed, as African-American patients were more likely to develop metabolic abnormalities than other ethnic groups, especially on clozapine.


CONCLUSIONS
In this prospective randomized trial, clozapine and olanzapine were associated with weight gain. Clozapine was associated with increases in both lipids and glucose. This effect was most prominent in the African-American patients.
Psychological Disorders and Psychosocial Resources of Patients with Newly Diagnosed Bladder and Kidney Cancer: A Cross-Sectional Study

PURPOSE
Psychological disorders have been proven to be associated with poor physiological, psychological and immune outcomes in cancer patients. However, despite of many challenges of the changed self-image/body image and the altered sexual/urinary function, relatively little is known about psychological disorders of patients with newly diagnosed bladder and kidney cancer. We aimed to investigate the prevalence of depression, anxiety, post-traumatic stress disorder (PTSD) and the associated psychosocial factors among bladder/kidney cancer patients.


METHODS
A cross-sectional study was conducted of consecutive inpatients with bladder/kidney cancer in the First Affiliated Hospital of China Medical University in Liaoning Province, northeast China. A total of 489 early-stage cancer patients eligible for this study completed questionnaires on demographic and clinical variables, depression, anxiety, PTSD, perceived social support and positive psychological variables (hope, optimism and resilience) anonymously during October 2013 and August 2014. Hierarchical regression analysis was used to examine the relationships between psychosocial resources and psychological disorders, while controlling for possible covariates.


RESULTS
The prevalence of depression, anxiety and PTSD was 77.5%, 69.3% and 25.2%, respectively, while 24.9% of patients had psychological co-morbidity. Psychosocial resources together explained more than one-third of the variance on psychological disorders. Under standardized estimate (β) sequence, patient's perception of social support from family was significantly associated with depression, anxiety and PTSD (p < 0.01). Optimism and resilience showed integrated and independent effects on psychological disorders, and hope represented the significant association with PTSD only (p < 0.01).


CONCLUSIONS
The high prevalence of psychological disorders in newly diagnosed patients with early-stage bladder/kidney cancer should receive more attention in Chinese medical settings. Additionally, in consideration of the different protective effects of psychosocial resources, the present study demonstrated that one complete psychological intervention integrating the associated psychosocial factors are necessary to ameliorate psychological disorders so as to provide patients with a more holistic cancer care.
Electronic Shopping

he global electronic market will have a profound impact on commerce in the 21st Century. While current U.S. sales in cyberspace ($1 billion in 1995) are small in comparison to total U.S. retail sales ($1.7 trillion in 1995) [3], U.S. cybersales projections for the year 2000 range from $7 to $117 billion [9]. More importantly, most experts predict a radical shift in how business will be conducted in the next century. This shift not only has businesses scrambling to meet this new marketing reality, but also raises many important research questions about business strategy, technical infrastructure, government policies, the electronic market demographics as well as how people will use the technology. Issues of technology usage become critical as businesses and retailers attempt to exploit the boom in electronic marketing. There are large differences between a physical store and its electronic counterpart. A help button on the home page of the Web shopping site replaces the sales clerk’s friendly advice and service. The familiar layout of the physical store becomes a maze of pull-down menus, product indices, and search features. Now more than ever, the promise of electronic commerce and online shopping will depend to a great extent upon the interface and how people interact with the computer. Account managers, production staff, and merchant partners should not assume customers do not want an item in an online retail store if it is not selling. Nor should they conclude that a poor response to a given store design is due to the merchandising mix. It is important to look at the relationship between sales and user interface design. Limited menus, poorly designed navigation, and the difficulty in comparing multiple products on the same screen all have adverse effects on electronic shopping [2]. Can customers find what they want in the stores? Are customers aware of what products are available? After all, diligence in browsing a store is not a virtue retailers should expect from its online customers. We review online retail store attributes such as the number of links into the store, image sizes, number of products, and store navigation features. By reviewing the user interface features in the context of electronic shopping, we hope to facilitate the process of designing and evaluating alternative storefronts by identifying key features that impact traffic and sales. While this article specifically addresses user interface design issues for electronic shopping, user interface design is an important component of all software development [10] with important implications for productivity [5]. Unfortunately, Web information systems (WIS) designers sometimes do not heed the importance of the message advocated by user interface design pundits such as Jakob Nielsen [11] and Vincent Flanders (www.webpagesthatsuck.com). Many of the lessons learned from online stores also apply to WIS applications.
The development of siblings of children with autism at 4 and 14 months: social engagement, communication, and cognition.

AIMS
To compare siblings of children with autism (SIBS-A) and siblings of children with typical development (SIBS-TD) at 4 and 14 months of age.


METHODS
At 4 months, mother-infant interactional synchrony during free play, infant gaze and affect during the still-face paradigm, and infant responsiveness to a name-calling paradigm were examined (n = 21 in each group). At 14 months, verbal and nonverbal communication skills were examined as well as cognition (30 SIBS-A and 31 SIBS-TD).


RESULTS
Most SIBS-A were functioning as well as the SIBS-TD at 4 and 14 months of age. However, some differences in early social engagement and later communicative and cognitive skills emerged. Synchrony was weaker in the SIBS-A dyads, but only for infant-led interactions. Infant SIBS-A revealed more neutral affect during the still-face procedure and were less upset by it than was true for the SIBS-TD. A surprising result was that significantly more SIBS-A responded to their name being called by their mothers compared to SIBS-TD. At 14 months, SIBS-A made fewer nonverbal requesting gestures and achieved lower language scores on the Bayley Scale. Six SIBS-A revealed a language delay of 5 months and were responsible for some of the significant differences between SIBS-A and SIBS-TD. Furthermore, infant SIBS-A who showed more neutral affect to the still face and were less able to respond to their name being called by their mothers initiated fewer nonverbal joint attention and requesting behaviors at 14 months, respectively.


DISCUSSION
Focused on the genetic liability for the broad phenotype of autism as well as the possible influence of having a sibling with autism.
Chloride-liberal fluids are associated with acute kidney injury after liver transplantation

INTRODUCTION
Acute kidney injury (AKI) occurs frequently after liver transplantation and is associated with significant morbidity and mortality. Recent evidence has linked the predominant usage of 'chloride-liberal' intravenous fluids, such as 0.9% saline to the development of renal dysfunction in general critically ill patients. We compared the effects of perioperative fluid types on AKI in liver transplant recipients.


METHODS
An observational analysis of liver transplant recipients over a 33-month period, between January 2010 and September 2013, was performed. Intensive care unit database and patient records were analyzed for determinants of early postoperative AKI. Univariate and multivariate regression analysis was carried out using a two-tailed P value less than 0.05 to establish significance. The institutional Research Ethics Committee approved the study methodology (RAC no. 2131 073).


RESULTS
One hundred and fifty-eight liver transplants were performed, AKI developed in 57 (36.1%) patients: 39 (68.4%) fully recovered, 13 (22.8%) developed chronic renal failure and 10 (17.5%) required long-term hemodialysis. On univariate regression analysis, AKI was significantly associated with greater than 3,200 ml of chloride-liberal fluids infused within the first postoperative day (HR 5.9, 95% CI 2.64, 13.2, P < 0.001), greater than 1,500 ml colloids received in the operating room (hazard ratio (HR) 1.97, 95% CI 1.01, 3.8, P = 0.046), vasopressor requirement for 48 hours posttransplant (HR 3.34, 95% CI 1.55, 7.21, P = 0.002), hyperchloremia at day 2 (HR 1.09, 95% CI 1.01, 1.18, P = 0.015) and preoperative model for end-stage liver disease (MELD) score (HR 1.08, 95% CI 1.03, 1.13, P < 0.001). After stepwise multivariate regression, infusion of greater than 3,200 ml of chloride-liberal fluids (HR 6.25, 95% CI 2.69, 14.5, P < 0.000) and preoperative MELD score (HR 1.08, 95% CI 1.02, 1.15, P = 0.004) remained significant predictors for AKI.


CONCLUSIONS
In a sample of liver transplant recipients, infusion of higher volumes of chloride-liberal fluids and preoperative status was associated with an increased risk for postoperative AKI.
Acupressure and meridian massage: combined effects on increasing body weight in premature infants.

AIMS AND OBJECTIVES
The purpose of this study was to assess the body weight gain of combined acupressure and meridian massage in premature infants.


BACKGROUND
Each year in Taiwan, 8-10% of newborns are delivered prematurely. Effective postnatal care is essential to ensure the healthy development of premature infants. Massage therapy has been administered to facilitate weight gain in the neonatal unit. The evidence-based findings in previous studies did not include acupressure or meridian massage.


DESIGN
A double-blind clinical trial was conducted in a medical centre in central Taiwan.


METHODS
Forty subjects were randomised into two groups. The 20 subjects in the experimental group were given a standard procedure of acupressure at Zhongwan, Zusanli, Yongquan, abdominal rubbing, spleen and stomach meridian massage, and kneading the points along the spine of the bladder meridian. These treatments were administered for 15 minutes per session, one hour before meals, three times daily over 10 days. The control group, also consisting of 20 subjects, underwent routine care and was observed. The infants' body weights and the volume of milk ingested were measured and recorded daily.


RESULTS
The daily average weight gain of the infants in the experimental group was 32.7 g (SD = 8.1) compared with 27.3 g (SD = 7.7) in the control group. While in the first week there was no significant difference in weight gain between the two groups; in the second week, the weight gain observed in the experimental group was significantly higher than that observed in the control group.


CONCLUSIONS
An experimental trial established the effects of using acupressure and meridian massage on increasing body weight in premature infants. Acupressure and meridian massage have a significant effect on weight gain in premature infants.


RELEVANCE TO CLINICAL PRACTICE
Nurses could be trained in acupressure and meridian massage techniques to provide more effective level of clinical care for premature infants.
Artificial Cognitive Systems: From VLSI Networks of Spiking Neurons to Neuromorphic Cognition

Neuromorphic engineering (NE) is an emerging research field that has been attempting to identify neural types of computational principles, by implementing biophysically realistic models of neural systems in Very Large Scale Integration (VLSI) technology. Remarkable progress has been made recently, and complex artificial neural sensory-motor systems can be built using this technology. Today, however, NE stands before a large conceptual challenge that must be met before there will be significant progress toward an age of genuinely intelligent neuromorphic machines. The challenge is to bridge the gap from reactive systems to ones that are cognitive in quality. In this paper, we describe recent advancements in NE, and present examples of neuromorphic circuits that can be used as tools to address this challenge. Specifically, we show how VLSI networks of spiking neurons with spike-based plasticity mechanisms and soft winner-take-all architectures represent important building blocks useful for implementing artificial neural systems able to exhibit basic cognitive abilities.
Accurate, Data-Efficient, Unconstrained Text Recognition with Convolutional Neural Networks

Unconstrained text recognition is an important computer vision task, featuring a wide variety of different sub-tasks, each with its own set of challenges. One of the biggest promises of deep neural networks has been the convergence and automation of feature extractors from input raw signals, allowing for the highest possible performance with minimum required domain knowledge. To this end, we propose a data-efficient, end-to-end neural network model for generic, unconstrained text recognition. In our proposed architecture we strive for simplicity and efficiency without sacrificing recognition accuracy. Our proposed architecture is a fully convolutional network without any recurrent connections trained with the CTC loss function. Thus it operates on arbitrary input sizes and produces strings of arbitrary length in a very efficient and parallelizable manner. We show the generality and superiority of our proposed text recognition architecture by achieving state of the art results on seven public benchmark datasets, covering a wide spectrum of text recognition tasks, namely: Handwriting Recognition, CAPTCHA recognition, OCR, License Plate Recognition, and Scene Text Recognition. Our proposed architecture has won the ICFHR2018 Competition on Automated Text Recognition on a READ Dataset.
Risk factors for progression to gastric neoplastic lesions in patients with atrophic gastritis.

BACKGROUND
Atrophic gastritis, involving the gastric body mucosa, predisposes to gastric neoplastic lesions (GNL). However, regular gastroscopic-histological follow-up for GNL is not recommended for patients with atrophic gastritis.


AIM
To evaluate risk factors for the progression to GNL in a cohort of patients with atrophic gastritis.


METHODS
A total of 300 patients with atrophic gastritis [205 women, aged 54 (18-78) years] underwent gastroscopy with six gastric antrum and body biopsies. All patients had at least one follow-up gastroscopy/histology at an interval of at least 1 year after the atrophic gastritis diagnosis. Baseline clinical and histological features were analysed as risk factors for the development of GNL by Cox-regression.


RESULTS
During a median follow-up of 4.3 (1-16.5) years, 15 GNL were detected in 14 of the 300 patients with atrophic gastritis: three were gastric cancer, whereas 12 were non-invasive neoplasia. The annual incidence for GNL was 1%. Cox-regression analysis identified the following risk factors: age over 50 years (HR 8.8, 95%CI 1.2-68.4), atrophic pangastritis (HR 4.5, 95% CI 1.5-14.1) and severe intestinal metaplasia in the gastric body (HR 4.0, 95% CI 1.3-11.8).


CONCLUSIONS
Atrophic pangastritis, severe body intestinal metaplasia and/or age over 50 years increase the risk for developing GNL in patients with atrophic gastritis. In this subset of patients, an endoscopic-histological follow-up for GNL surveillance may be worthwhile.
Learning Program Behavior Profiles for Intrusion Detection

Pro ling the behavior of programs can be a useful reference for detecting potential intrusions against systems This paper presents three anomaly detec tion techniques for pro ling program behavior that evolve from memorization to generalization The goal of monitoring program behavior is to be able to detect potential intrusions by noting irregularities in program behavior The techniques start from a simple equality matching algorithm for determining anomalous behavior and evolve to a feed forward backpropagation neural network for learning pro gram behavior and nally to an Elman network for recognizing recurrent features in program execution traces In order to detect future attacks against sys tems intrusion detection systems must be able to generalize from past observed behavior The goal of this research is to employ machine learning tech niques that can generalize from past observed be havior to the problem of intrusion detection The performance of these systems is compared by testing them with data provided by the DARPA Intrusion Detection Evaluation program
An application of cascaded 3D fully convolutional networks for medical image segmentation

Recent advances in 3D fully convolutional networks (FCN) have made it feasible to produce dense voxel-wise predictions of volumetric images. In this work, we show that a multi-class 3D FCN trained on manually labeled CT scans of several anatomical structures (ranging from the large organs to thin vessels) can achieve competitive segmentation results, while avoiding the need for handcrafting features or training class-specific models. To this end, we propose a two-stage, coarse-to-fine approach that will first use a 3D FCN to roughly define a candidate region, which will then be used as input to a second 3D FCN. This reduces the number of voxels the second FCN has to classify to ∼10% and allows it to focus on more detailed segmentation of the organs and vessels. We utilize training and validation sets consisting of 331 clinical CT images and test our models on a completely unseen data collection acquired at a different hospital that includes 150 CT scans, targeting three anatomical organs (liver, spleen, and pancreas). In challenging organs such as the pancreas, our cascaded approach improves the mean Dice score from 68.5 to 82.2%, achieving the highest reported average score on this dataset. We compare with a 2D FCN method on a separate dataset of 240 CT scans with 18 classes and achieve a significantly higher performance in small organs and vessels. Furthermore, we explore fine-tuning our models to different datasets. Our experiments illustrate the promise and robustness of current 3D FCN based semantic segmentation of medical images, achieving state-of-the-art results.1.
Cache-timing attacks on AES

This paper demonstrates complete AES key recovery from known-plaintext timings of a network server on another computer. This attack should be blamed on the AES design, not on the particular AES library used by the server; it is extremely difficult to write constant-time high-speed AES software for common general-purpose computers. This paper discusses several of the obstacles in detail.
Inhaled hypertonic saline in infants and toddlers with cystic fibrosis: short-term tolerability, adherence, and safety.

BACKGROUND
Inhaled hypertonic saline (HS) is an attractive agent for chronic maintenance therapy in infants and toddlers with cystic fibrosis (CF) because it improves defective mucociliary clearance. Prior to undertaking a clinical trial of HS efficacy in young children with CF, tolerability, adherence, and safety must be established.


METHODS
Three-center, open label evaluation of the short-term tolerability, adherence, and safety of 7% HS administered twice daily for 14 days in children with CF 12-30 months of age. The primary objective was to evaluate the proportion of participants unable to tolerate single and repeated doses of 7% HS according to protocol-defined criteria. Participants inhaled a test dose of HS at the enrollment visit; test dose intolerance was defined as fulfillment of at least one of 4 criteria. Participants who tolerated the test dose inhaled 7% HS twice daily for 14±2 days.


RESULTS
Twenty children were enrolled. One was withdrawn due to maternal concern over fussiness with application of the facemask for the test dose. Of the 19 participants administered the test dose, 1 was withdrawn due to test dose intolerance (5%, 95% confidence interval 0, 26%). Eighteen participants completed the study; 1 was intolerant (95% CI 0, 27%) at the final visit due to new wheezes on exam in association with an upper respiratory infection and otitis media. Home symptom diaries demonstrated cough as the main symptom in the hour following inhalation, which decreased in frequency over the study period. Adherence as assessed by daily home diary and returned study drug ampoules was high. Participants reported receiving both treatments on a median of 100% of days; a median of 25 ampoules were used during a median of 13 days.


CONCLUSIONS
7% HS appears well tolerated for up to 14 days in infants and toddlers with CF, with high adherence. These results provide encouraging short-term tolerability and adherence data for future trials assessing the safety and efficacy of 7% HS in young children with CF.