LLukas22/scidocs huggingface dataset:
Validation of HPLC-UV method for determination of amoxicillin Trihydrate in capsule

The intention of the present work is to validate an easy, better and reasonable approach for estimation of amoxicillin trihydrate in tablet formulation by opposite segment(reverse phase) HPLC –UV with advanced conditions and parameters for habitual use in Rwanda well known board in pharmaceutical laboratory in order to check if no substandard or counterfeit amoxicillin has entered in our country that can result in antimicrobial resistance, treatment failure which can be a chief diffi culty on public health. an easy, selective, precise, speedy, specifi c, and correct reverse phase HPLC UV-seen technique has been verifi ed for the dedication of amoxicillin, in addition that is a cost-effective technique for the established method, monobasic potassium phosphate (KH2PO4) used as buffer and methanol and had been used as a mobile section in the ratio 95:5 respectively. The elution turned into fi nished in an isocratic mode at a go with the fl ow rate of 1.5ml/minute proposed method became demonstrated as according to ICH guiding principle refereeing additionally to USP necessities for amoxicillin capsule. linearity range of amoxicillin and was evaluated inside the variety of 20–160 g/ml. the correlation coeffi cient r2 changed into 0.9998 and the relative well known deviation between six replicates injection was always much less than 2%. The retention time was found 3.5±0.02. the high percentage of healing of amoxicillin is 100.6±4% indicates that the proposed method is exceptionally correct and precise trueness of with the trueness of 100.06±1.2% .the statistical evaluation proved that the demonstrated method is appropriate for analysis of amoxicillin as the majority drug and pharmaceutical formula with none interference from excipients .with the aid of considering the effi ciency of the drug samples, all analyzed pattern were within the variety of 90-120 % of percentage of labeled amount, but the effi ciency had been distinctive amongst samples. The have a look at located that no counterfeit, no substandard product turned into amongst all batches of amoxicillin samples throughout the c programming language of the look at. Review Article Validation of HPLC-UV method for determination of amoxicillin Trihydrate in capsule Sendanyoye Marcel*, Uwambajineza Tito, Ineza Ines and Nahimana Jean Pierre University of Rwanda, College of Medicine and Health Science, Department of Pharmacy, Kigali, Rwanda *Address for Correspondence: Sendanyoye Marcel, University of Rwanda, College of Medicine and Health Science, Department of Pharmacy, Kigali, Rwanda, Tel: +250783493980; Email: marcellomarcello@yahoo.com Submitted: 14 September 2018 Approved: 03 October 2018 Published: 04 October 2018 Copyright: © 2018 Marcel S, et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Validity of a virtual environment for stroke rehabilitation.

BACKGROUND AND PURPOSE
Virtual environments for use in stroke rehabilitation are in development, but there has been little evaluation of their suitability for this purpose. We evaluated a virtual environment developed for the rehabilitation of the task of making a hot drink.


METHODS
Fifty stroke patients undergoing rehabilitation in a UK hospital stroke unit were involved. The performance of stroke rehabilitation patients when making a hot drink had the neurological impairments associated with performance of this task, and the errors observed were compared for standardized task performance in the real world and in a virtual environment. Neurological impairments were measured using standardized assessments. Errors in task performance were assessed rating video recordings and classified into error types.


RESULTS
Real-world and virtual environment performance scores were not strongly associated (rho=0.30; P<0.05). Performance scores in both settings were associated with age, Barthel ADL score, Mini Mental State Examination score, and tests of visuospatial function. Real-world performance only was associated with arm function and sequencing ability. Virtual environment performance only was associated with language function and praxis. Participants made different errors during task performance in the real world and in the virtual environment.


CONCLUSIONS
Although this virtual environment was usable by stroke rehabilitation patients, it posed a different rehabilitation challenge from the task it was intended to simulate, and so it might not be as effective as intended as a rehabilitation tool. Other virtual environments for stroke rehabilitation in development require similar evaluation.
CertiCoq : A verified compiler for Coq

CertiCoq is a mechanically verified, optimizing compiler for Coq that bridges the gap between certified high-level programs and their translation to machine language. We outline its design as well as the main foundational and engineering challenges involved in building and certifying a compiler for Coq in Coq.
Strategic Management of Distressed Inventory

I is well known that maximizing revenue from a fixed stock of perishable goods may require discounting prices rather than allowing unsold inventory to perish. This behavior is seen in industries ranging from fashion retail to tour packages and baked goods. A number of authors have addressed the markdown management problem in which a seller seeks to determine the optimal sequence of discounts to maximize the revenue from a fixed stock of perishable goods. However, merchants who consistently use markdown policies risk training customers to “wait for the sale.” We investigate models in which the decision to sell inventory at a discount will change the future expectations of customers and hence their buying behavior. We show that, in equilibrium, a single-price policy is optimal if all consumers are strategic and demand is known to the seller. Relaxing any of these conditions can lead to a situation in which a two-price markdown policy is optimal. We show using numerical simulation that if customers update their expectations of availability over time, then optimal sales limit policies can evolve in a complex fashion.
Deleterious effect of right ventricular apical pacing on left ventricular diastolic function and the impact of pre-existing diastolic disease.

AIMS
Right ventricular apex (RVA) pacing may have deleterious effects on left ventricular (LV) systolic function, but its impact on LV diastolic function has not been explored.


METHODS AND RESULTS
Ninety-seven patients with sinus node dysfunction and ejection fraction (EF) ≥ 50% with permanent RVA pacing were randomly programmed to V-sense and V-pace modes and examined by echocardiography. Tissue Doppler imaging was employed to assess myocardial systolic velocity (S') and early diastolic velocity (E') at the mitral annulus. Systolic dyssynchrony was assessed using 12 LV segmental model (Ts-SD). Switching from V-sense to V-pace resulted in the worsening of both diastolic and systolic functions as shown by the decreased EF, reduced mean E' and S' velocities, as well as increase in LV volume and Ts-SD (all P< 0.001). Reduction of mean E' and S' of ≥ 1 cm/s occurred in 35 (36%) and 45 (46%) patients, respectively. In pre-defined subgroup analysis, only patients with pre-existing LV diastolic dysfunction had a significant reduction of mean E' and S' (both P< 0.001) even after age adjustment. Multivariate logistic regression analysis showed that independent factors for the reduction of mean E' ≥ 1 cm/s or mean S' ≥ 1 cm/s at V-pace were pre-existing LV diastolic dysfunction [odds ratio (OR): 4.735, P= 0.007 for E'; OR: 3.307, P= 0.022 for S'] and systolic dyssynchrony at V-pace (OR: 5.459, P= 0.007 for E'; OR: 2.725, P= 0.035 for S').


CONCLUSION
In patients with preserved EF, RVA pacing is associated with the deterioration of both LV diastolic and systolic functions, which is particularly obvious in those with pre-existing LV diastolic dysfunction and V-pace-induced systolic dyssynchrony.
Analogical Representation of Spatial Events for Understanding Traffic Behaviour

In computer vision the usual level of \in-terpretation" is the identiication of the objects in the image. In this paper, we extend the level of interpretation to include spatial event detection using a knowledge base for a known scene. This will allow us to formulate a computational theory for forming conceptual descriptions about the behaviours of the objects. Here we describe an analogical representation of space and time that supports the formation of these conceptual descriptions and allows strong contextual indexing of our spatial knowledge.
Effects of Glutamine on Glycemic Control During and After Exercise in Adolescents With Type 1 Diabetes

OBJECTIVE
To investigate if oral glutamine ameliorates exercise and postexercise nighttime hypoglycemia in type 1 diabetic adolescents.


RESEARCH DESIGN AND METHODS
Ten adolescents (15.2 +/- 1.4 years [SD], A1C 6.9 +/- 0.9%) on insulin pumps were studied. The subjects were randomized to receive a glutamine or placebo drink pre-exercise and at bedtime (0.25 g/kg/dose). A 3:00 p.m. exercise session consisted of four 15-min treadmill/5-min rest cycles. Pre-exercise blood glucose was 140-150 mg/dl and was monitored throughout the night. Studies were randomized crossover over 3 weeks.


RESULTS
Blood glucose levels dropped comparably (52%) during exercise on both days. However, the overnight number of hypoglycemic events was higher on glutamine than placebo (<or=70 mg/dl, P = 0.03 and <or=60, P = 0.05). The cumulative probability of nighttime hypoglycemia was increased on glutamine days (80%) versus placebo days (50%) (P = 0.02).


CONCLUSIONS
Glutamine increased the cumulative probability of postexercise overnight hypoglycemia compared with placebo in adolescents with type 1 diabetes. Whether glutamine may enhance insulin sensitivity postexercise requires further study in type 1 diabetes.
Patient-centred care in established rheumatoid arthritis.

Review of the evidence on patient-centred care (PCC) in rheumatoid arthritis (RA) shows that involving the patient as an individual - with unique needs, concerns and preferences - has a relevant impact on treatment outcomes (safety, effectiveness and costs). This approach empowers patients to take personal responsibility for their treatment. Because clinicians are only able to interact personally with their patients just a few hours per year, patients with a chronic condition such as RA should be actively involved in the management of their disease. To stimulate this active role, five different PCC activities can be distinguished: (1) patient education, (2) patient involvement/shared decision-making, (3) patient empowerment/self-management, (4) involvement of family and friends and (5) physical and emotional support. This article reviews the existing knowledge on these five PCC activities in the context of established RA management, especially focused on opportunities to increase medication adherence in established RA.
New Low-Frequency Dispersion Model for AlGaN/GaN HEMTs Using Integral Transform and State Description

A new concept for the low-frequency dispersion aspect of large-signal modeling of microwave III-V field-effect transistors is presented. The approach circumvents the integrability problem between the small-signal transconductance GmRF and the output conductance GdsRF by means of an integral formulation and simultaneously yields a proper description of the drain channel current in the small- and large-signal regime. In the theoretical description of the approach and in an extraction example of an AlGaN/GaN HEMT, it is shown that three independent 2-D nonlinear quantities determine the intrinsic drain channel current (GmRF, GdsRF, and dc current). The concept is transferred to the modeling of the nonlinear charge control, where the integrability problem between the large-signal charge functions and the small-signal intrinsic capacitance matrix (Cgs, Cgd, and Cds) is addressed consistently under consideration of the charge control delays. For the large-signal modeling under pulsed-dc/RF excitation, the dc continuous wave (dc-CW) modeling approach is combined with the state-modeling concept using a superposition formula for drain current and charges, respectively. The new model is implemented in ADS using a 12- and 14-port symbolically defined device for both the dc-CW and pulsed-RF case, respectively. The model has been verified by comparison to measured CW and pulsed-RF load-pull and waveform data at 10-GHz fundamental frequency.
Reconstructing the Human Past using Ancient and Modern Genomes

The study of DNA variation is one of the most promising avenues for learning about the evolutionary and historical past of humans and other species. However, the difficulty associated with obtainin ...
SU(4) pure-gauge phase structure and string tensions☆☆☆

Abstract We present numerical evidence that the SU(4) pure-gauge dynamics has a finite-temperature first-order phase transition. For a 6 × 20 3 lattice, this transition occurs at the inverse-square coupling of 8 g 2 /≈ 10.79 . Below this and above the known bulk phase transition at 8 g 2 ≈10.2 is a confined phase in which we find two different string tensions, one between the fundamental 4 and 4 ∗ representations and the other between the self-dual diquark 6 representations. The ratio of these two is about 1.5. The correlation in the adjoint representation suggests no string forms between adjoint charges.
Effects of Cable on the Dynamics of a Cantilever Beam with Tip Mass

The dynamic effects of cable attachment on a cantilever beam with tip mass are investigated by an improved Chebyshev spectral element method. The cabled beam is modeled as a double-beam system connected by springs at several discrete locations. By utilizing high order Chebyshev polynomials as basis functions and meshing the system at the locations of connections, precise numerical results of the natural frequencies and mode shapes can be obtained using only a few elements. The accuracy of this method is validated through comparing the results of finite element method and those of spectral element method in literature.The validatedmethod is implemented to investigate the effects of parameters, including spring stiffness, number of connections, density, and Young’s modulus of cable. The results show that the mode shapes of the cabled beam system can be classified into two types: beam mode shapes and cable mode shapes, according to their main deformation. Their corresponding natural frequencies change in very different ways with the variation of system parameters. This work can be applied to optimize the dynamic characteristics of precise spacecraft structures with cable attachments.
Information Technology Adoption in Small and Medium-sized Enterprises ; An Appraisal of Two Decades Literature

Small to medium-sized enterprises (SMEs) account for major source of employment, technological advancements, and competitive advantages for both developed and developing countries. Owing to the intensified competitive pressure and necessity for entering to global market undergone by SMEs, these businesses are incrementally employing Information Technology (IT) to take advantage of its substantial benefits. Most of prior researches have more focused on IT adoption in large organizations. However, and with regard to the limited resources controlled by SMEs, the process of IT adoption in this business sector is considerably different. The purpose of this paper is to analyze and contrast the internal and external issues affecting the process of IT adoption in SMEs to provide clearer understanding of this process by reviewing IT adoption literature, which includes more than 20 years of empirical research and case studies from a variety of databases with high concentration on certain SME-related issues. Proposed integrated framework demonstrates the process of IT adoption in SMEs through reviewing exiting perspectives in the literature. This study will assist different parties involved with adoption process including managers, vendors, consultants, and governments to achieve a practical synopsis of the IT adoption process in SMEs, which is believed to assist them with successful adoption.
Surfacing Tacit Knowledge in Requirements Negotiation: Experiences using Easy Win Win

Defects in the requirements definition process often lead to costly project failures. One eminent problem is that it can be difficult to take deliberate advantage of important tacit knowledge of success-critical stakeholders. People know more that they can ever tell. Implicit stakeholder goals, hidden assumptions, unshared expectations often result in severe problems in the later stages of software development. In this paper, we will present a set of collaborative techniques that support a team of success-critical stakeholders in surfacing tacit knowledge during systems development projects. We will discuss these techniques in the context of the EasyWinWin requirements negotiation methodology and illustrate our approach with examples from real-world negotiations.
Meaning in life across the life span : Levels and correlates of meaning in life from emerging adulthood to older adulthood

This article may be used for research, teaching and private study purposes. Any substantial or systematic reproduction, redistribution , reselling , loan or sub-licensing, systematic supply or distribution in any form to anyone is expressly forbidden. The publisher does not give any warranty express or implied or make any representation that the contents will be complete or accurate or up to date. The accuracy of any instructions, formulae and drug doses should be independently verified with primary sources. The publisher shall not be liable for any loss, actions, claims, proceedings, demand or costs or damages whatsoever or howsoever caused arising directly or indirectly in connection with or arising out of the use of this material. Meaning in life is thought to be important to well-being throughout the human life span. We assessed the structure, levels, and correlates of the presence of meaning in life, and the search for meaning, within four life stage groups: emerging adulthood, young adulthood, middle-age adulthood, and older adulthood. Results from a sample of Internet users (N ¼ 8756) demonstrated the structural invariance of the meaning measure used across life stages. Those at later life stages generally reported a greater presence of meaning in their lives, whereas those at earlier life stages reported higher levels of searching for meaning. Correlations revealed that the presence of meaning has similar relations to well-being across life stages, whereas searching for meaning is more strongly associated with well-being deficits at later life stages. Introduction Meaning in life has enjoyed a renaissance of interest in recent years, and is considered to be an important component of broader well-being (e. Perceptions of meaning in life are thought to be related to the development of a coherent sense of one's identity (Heine, Proulx, & Vohs, 2006), and the process of creating a sense of meaning theoretically begins in adolescence, continuing throughout life (Fry, 1998). Meaning creation should then be linked to individual development, and is likely to unfold in conjunction with other processes, such as the development of identity, relationships, and goals. Previous research has revealed that people experience different levels of the presence of meaning at different ages (e.g., Ryff & Essex, 1992), although these findings have been inconsistent, and inquiries have generally focused on limited age ranges (e.g., Pinquart, 2002). The present study aimed to integrate research on dimensions of meaning in life across the life span by providing an analysis …
Simultaneous assay of pigments, carbohydrates, proteins and lipids in microalgae.

Biochemical compositional analysis of microbial biomass is a useful tool that can provide insight into the behaviour of an organism and its adaptational response to changes in its environment. To some extent, it reflects the physiological and metabolic status of the organism. Conventional methods to estimate biochemical composition often employ different sample pretreatment strategies and analytical steps for analysing each major component, such as total proteins, carbohydrates, and lipids, making it labour-, time- and sample-intensive. Such analyses when carried out individually can also result in uncertainties of estimates as different pre-treatment or extraction conditions are employed for each of the component estimations and these are not necessarily standardised for the organism, resulting in observations that are not easy to compare within the experimental set-up or between laboratories. We recently reported a method to estimate total lipids in microalgae (Chen, Vaidyanathan, Anal. Chim. Acta, 724, 67-72). Here, we propose a unified method for the simultaneous estimation of the principal biological components, proteins, carbohydrates, lipids, chlorophyll and carotenoids, in a single microalgae culture sample that incorporates the earlier published lipid assay. The proposed methodology adopts an alternative strategy for pigment assay that has a high sensitivity. The unified assay is shown to conserve sample (by 79%), time (67%), chemicals (34%) and energy (58%) when compared to the corresponding assay for each component, carried out individually on different samples. The method can also be applied to other microorganisms, especially those with recalcitrant cell walls.
The welfare costs of unreliable water service

Throughout the developing world, many water distribution systems are unreliable. As a result, it becomes necessary for each household to store its own water as a hedge against this uncertainty. Since arrivals of water are not synchronized across households, serious distributional inefficiencies arise. We develop a model describing the optimal intertemporal depletion of each household’s private water storage when it is uncertain when water will next arrive to replenish supplies. The model is calibrated using survey data from Mexico City, a city where many households store water in sealed rooftop tanks known as tinacos. The calibrated model is used to evaluate the potential welfare gains that would occur if alternative modes of water provision were implemented. We estimate that most of the potential distributional inefficiencies can be eliminated simply by making the frequency of deliveries the same across households which now face haphazard deliveries. This would require neither costly investments in infrastructure nor price increases.