LLukas22/scidocs huggingface dataset:
Symptoms and treatment when death is expected in dementia patients in long-term care facilities

BACKGROUND
Although dementia at the end of life is increasingly being studied, we lack prospective observational data on dying patients. In this study symptoms were observed in patients with dementia in the last days of life.


METHODS
When the elderly care physicians in two Dutch nursing homes expected death within one week, symptoms of (dis)comfort, pain and suffering were observed twice daily. For this the Pain Assessment in Advanced Dementia (PAINAD; range 0-10), Discomfort Scale-Dementia of Alzheimer Type (DS-DAT; range 0-27), End-Of-Life in Dementia-Comfort Assessment in Dying (EOLD-CAD; range 14-42) and an adapted version of the Mini-Suffering State Examination (MSSE; range 0-9), were used. Information on care, medical treatment and treatment decisions were also collected.


RESULTS
Twenty-four participants (median age 91 years; 23 females), were observed several times (mean of 4.3 observations (SD 2.6)), until they died. Most participants (n = 15) died from dehydration/cachexia and passed away quietly (n = 22). The mean PAINAD score was 1.0 (SD 1.7), DS-DAT 7.0 (SD 2.1), EOLD-CAD 35.1 (SD 1.7), and MSSE 2.0 (SD 1.7). All participants received morphine, six received antibiotics, and rehydration was prescribed once.


CONCLUSION
In these patients with dementia and expected death, a low symptom burden was observed with validated instruments, also in dehydrated patients without aggressive treatment. A good death is possible, but might be enhanced if the symptom burden is regularly assessed with validated instruments. The use of observation tools may have influenced the physicians to make treatment decisions.
Comparison of the efficacy of transcutaneous electrical nerve stimulation, interferential currents, and shortwave diathermy in knee osteoarthritis: a double-blind, randomized, controlled, multicenter study.

OBJECTIVE
To compare the effectiveness of transcutaneous electrical nerve stimulation (TENS), interferential currents (IFCs), and shortwave diathermy (SWD) against each other and sham intervention with exercise training and education as a multimodal package.


DESIGN
A double-blind, randomized, controlled, multicenter trial.


SETTING
Departments of physical medicine and rehabilitation in 4 centers.


PARTICIPANTS
Patients (N=203) with knee osteoarthritis (OA).


INTERVENTIONS
The patients were randomized by the principal center into the following 6 treatment groups: TENS sham, TENS, IFCs sham, IFCs, SWD sham, and SWD. All interventions were applied 5 times a week for 3 weeks. In addition, exercises and an education program were given. The exercises were carried out as part of a home-based training program after 3 weeks' supervised group exercise.


MAIN OUTCOME MEASURES
Primary outcome was a visual analog scale (0-100mm) to assess knee pain. Other outcome measures were time to walk a distance of 15m, range of motion, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Nottingham Health Profile, and paracetamol intake (in grams).


RESULTS
We found a significant decrease in all assessment parameters (P<.05), without a significant difference among the groups except WOMAC stiffness score and range of motion. However, the intake of paracetamol was significantly lower in each treatment group when compared with the sham groups at 3 months (P<.05). Also, the patients in the IFCs group used a lower amount of paracetamol at 6 months (P<.05) in comparison with the IFCs sham group.


CONCLUSIONS
Although all groups showed significant improvements, we can suggest that the use of physical therapy agents in knee OA provided additional benefits in improving pain because paracetamol intake was significantly higher in the patients who were treated with 3 sham interventions in addition to exercise and education.
Sickle cell disease

Sickle cell disease (SCD) is a group of inherited disorders caused by mutations in HBB, which encodes haemoglobin subunit β. The incidence is estimated to be between 300,000 and 400,000 neonates globally each year, the majority in sub-Saharan Africa. Haemoglobin molecules that include mutant sickle β-globin subunits can polymerize; erythrocytes that contain mostly haemoglobin polymers assume a sickled form and are prone to haemolysis. Other pathophysiological mechanisms that contribute to the SCD phenotype are vaso-occlusion and activation of the immune system. SCD is characterized by a remarkable phenotypic complexity. Common acute complications are acute pain events, acute chest syndrome and stroke; chronic complications (including chronic kidney disease) can damage all organs. Hydroxycarbamide, blood transfusions and haematopoietic stem cell transplantation can reduce the severity of the disease. Early diagnosis is crucial to improve survival, and universal newborn screening programmes have been implemented in some countries but are challenging in low-income, high-burden settings.
Ocean robotics for sustainable, long-range marine resource and ecosystem management in the 21st century : natural environment

Multi-month ocean glider deployments in the Southern Ocean have resulted in the collection of unprecedented ocean climate data from the remotest and harshest ocean environments. Now we are beginning to use this technology to enhance our marine resource and ecosystem governance in South Africa's exclusive economic zone and beyond.
Sibling Gender Composition and Participation in STEM Education

This paper studies the causal impact of sibling gender composition on participation in Science, Technology, Engineering, and Mathematics (STEM) education. I focus on a sample of first-born children who all have a younger biological sibling, using rich administrative data on the total Danish population. The randomness of the secondborn siblings’ gender allows me to estimate the causal effect of having an opposite sex sibling relative to a same sex sibling. The results are robust to family size and show that having a second-born opposite sex sibling makes first-born men more and women less likely to enroll in a STEM program. Although sibling gender composition has no impact on men’s probability of actually completing a STEM degree, it has a powerful effect on women’s success within these fields: women with a younger brother are eleven percent less likely to complete any field-specific STEM education relative to women with a sister. I provide evidence that parents of mixed sex children gender-specialize their parenting more than parents of same sex children. These findings indicate that the family environment plays in important role for shaping interests in STEM fields. JEL classification: I2, J1, J3
Attitudes and knowledge levels of nurses and residents caring for adolescents with an eating disorder.

UNLABELLED
Although the vast majority of youths with an eating disorder (ED) are treated as outpatients, some require treatment in an inpatient unit. The purpose of this study was to determine the attitudes of nurses and pediatric residents towards adolescents and young adults with ED.


METHODS
Nursing questionnaires were distributed through a nurse manager and resident questionnaires were distributed in coordination with the chief residents.


RESULTS
A total of 82 individuals (32 nurses and 50 pediatric residents) completed the survey. Only two nurses and six residents had not worked with a patient with an ED in the previous year. The vast majority of nurses and residents recognized that fear of gaining weight, refusal to maintain body weight and, disturbed body image were frequent signs occurring in patients with an ED. Both nurses and residents believed that emotional problems, influence of friends and family, family pressure, influence of the media, and being self-induced were the most likely causes of EDs. Genetics and influence of other medical problems were deemed less likely causes. The majority of residents identified having different rules for different patients and poor communication as factors that make it difficult to take care of ED patients. More than half of all nurses and residents (58.2%) thought that ED patients were responsible for their disease "always" or "in most cases". Residents (68.8%) were more likely than nurses (45.2%) to frequently feel frustrated with ED patients (χ2, p<0.0370).


CONCLUSION
Adolescents with an ED provide a unique challenge to nurses and residents caring for them.
Outdoor dynamic subject-specific evaluation of internal stresses in the residual limb: hydraulic energy-stored prosthetic foot compared to conventional energy-stored prosthetic feet.

The prosthetic foot plays an important role in propelling, breaking, balancing and supporting body loads while the amputee ambulates on different grounds. It is therefore important to quantify the effect of the prosthetic foot mechanism on biomechanical parameters, in order to prevent pressure ulcers and deep tissue injury. Our aim was to monitor the internal stresses in the residuum of transtibial amputation (TTA) prosthetic-users ambulating on different terrains, which the amputees encounter during their daily activities, i.e. paved floor, grass, ascending and descending stairs and slope. We specifically aimed to compare between the internal stresses in the TTA residuum of amputees ambulating with a novel hydraulic prosthetic foot compared to conventional energy storage and return (ESR) prosthetic feet. Monitoring of internal stresses was accomplished using a portable subject-specific real-time internal stress monitor. We found significant decrease (p<0.01) in peak internal stresses and in the loading rate of the amputated limb, while walking with the hydraulic foot, compared to walking with ESR feet. The loading rate calculated while ambulating with the hydraulic foot was at least three times lower than the loading rate calculated while ambulating with the ESR foot. Although the average decrease in internal stresses was ≈ 2-fold larger when replacing single-toe ESR feet with the hydraulic foot than when replacing split-toed ESR feet with the hydraulic foot, the differences were statistically insignificant. Our findings suggest that using a hydraulic prosthetic foot may protect the distal tibial end of the TTA residuum from high stresses, therefore preventing pressure-related injury and pain.
Context-Aware Emotion-Based Model for Group Decision Making

This context-aware emotion-based model can help design intelligent agents for group decision making processes. Experiments show that agents with emotional awareness reach agreement more quickly than those without it.
Intrusion Detection and Countermeasure of Virtual Cloud Systems - State of the Art and Current Challenges

Clouds are distributed Internet-based platforms that provide highly resilient and scalable environments to be used by enterprises in a multitude of ways. Cloud computing offers enterprises technology innovation that business leaders and IT infrastructure managers can choose to apply based on how and to what extent it helps them fulfil their business requirements. It is crucial that all technical consultants have a rigorous understanding of the ramifications of cloud computing as its influence is likely to spread the complete IT landscape. Security is one of the major concerns that is of practical interest to decision makers when they are making critical strategic operational decisions. Distributed Denial of Service (DDoS) attacks are becoming more frequent and effective over the past few years, since the widely publicised DDoS attacks on the financial services industry that came to light in September and October 2012 and resurfaced in the past two years. In this paper, we introduce advanced cloud security technologies and practices as a series of concepts and technology architectures, from an industry-centric point of view. This is followed by classification of intrusion detection and prevention mechanisms that can be part of an overall strategy to help understand identify and mitigate potential DDoS attacks on business networks. The paper establishes solid coverage of security issues related to DDoS and virtualisation with a focus on structure, clarity, and well-defined blocks for mainstream cloud computing security solutions and platforms. In doing so, we aim to provide industry technologists, who may not be necessarily cloud or security experts, with an effective tool to help them understand the security implications associated with cloud adoption in their transition towards more knowledge-based systems. Keywords—Cloud Computing Security; Distributed Denial of Service; Intrusion Detection; Intrusion Prevention; Virtualisation
Baclofen add-on to citalopram in treatment of posttraumatic stress disorder.

OBJECTIVE
Posttraumatic stress disorder (PTSD) is a chronic disabling illness, resulting from exposure to extreme traumatic event. Although different pharmacologic agents are suggested for treatment of PTSD, none have been completely effective in eliminating symptoms. The purpose of this study was to assess the use of baclofen as an add-on to citalopram in treatment of PTSD.


METHODS
In this double-blind clinical trial, 40 Iranian combat veterans with PTSD were randomly assigned to 2 groups. The first group received a combination treatment of 20 to 60 mg/d citalopram and 40 mg/d baclofen, and the second group received 20 to 60 mg/d citalopram plus placebo. Symptom severity was assessed by Clinician-Administered PTSD Scale at the beginning of the study and after 2, 4, 6, and 8 weeks. Global Assessment of Functioning and Hamilton Rating Scale for Anxiety and Depression were also used at the same periods. Data were analyzed with independent t test and paired t test using SPSS software version 13 (IBM, Armonk, NY).


RESULTS
Twenty-three male patients (baclofen group, 13 patients; placebo group, 10 patients) completed the study. Dropout from the treatment was not caused by adverse effects of the new medications in any of the subjects. Baclofen group showed significantly larger improvement in Clinician-Administered PTSD Scale total (P = 0.040), hyperarousal (P = 0.020), and avoidance (0.020) scores, Global Assessment of Functioning score (0.001), depression (P = 0.000), and anxiety (P = 0.000) after 8 weeks of treatment. No intergroup difference was found in improvement of reexperience symptoms (P = 0.740).


CONCLUSIONS
Baclofen showed to be an effective add-on to selective serotonin reuptake inhibitors in treatment of PTSD for better symptom recovery and functional improvement.
Enhanced Negative Emotion and Alcohol Craving, and Altered Physiological Responses Following Stress and Cue Exposure in Alcohol Dependent Individuals

Chronic alcohol abuse is associated with changes in stress and reward pathways that could alter vulnerability to emotional stress and alcohol craving. This study examines whether chronic alcohol abuse is associated with altered stress and alcohol craving responses. Treatment-engaged, 28-day abstinent alcohol-dependent individuals (ADs; 6F/22M), and social drinkers (SDs; 10F/18M) were exposed to a brief guided imagery of a personalized stressful, alcohol-related and neutral-relaxing situation, one imagery condition per session, presented in random order across 3 days. Alcohol craving, anxiety and emotion ratings, behavioral distress responses, heart rate, blood pressure, and salivary cortisol measures were assessed. Alcohol patients showed significantly elevated basal heart rate and salivary cortisol levels. Stress and alcohol cue exposure each produced a significantly enhanced and persistent craving state in alcohol patients that was marked by increased anxiety, negative emotion, systolic blood pressure responses, and, in the case of alcohol cue, behavioral distress responses, as compared to SDs. Blunted stress-induced cortisol responses were observed in the AD compared to the SD group. These data are the first to document that stress and cue exposure induce a persistent negative emotion-related alcohol craving state in abstinent alcoholics accompanied by dysregulated HPA and physiological arousal responses. As laboratory models of stress and negative mood-induced alcohol craving are predictive of relapse outcomes, one implication of the current data is that treatments targeting decreases in stress and alcohol cue-induced craving and regulation of stress responses could be of benefit in improving alcohol relapse outcomes.
Fast 3D Near-infrared breast imaging using indocyanine green for detection and characterization of breast lesions.

PURPOSE
To evaluate fast 3D near-infrared breast imaging using the optical contrast agent indocyanine green (ICG) for the detection and characterization of breast lesions.


MATERIALS AND METHODS
30 patients with suspicious breast lesions on mammography and/or ultrasound underwent fast 2 Hz 3D optical mammography before, during, and after administration of a 25 mg ICG bolus prior to needle biopsy. The bolus kinetics is analyzed using two perfusion parameters and a derived parameter: "peak amplitude" (PA), "time-to-peak" (TTP) and "peak-time grouped amplitude" (PTA). A receiver operating characteristic curve (ROC) analysis was performed to define a PTA cut-off for reader-independent differentiation of benign and malignant lesions. 8 patients had to be excluded from data analysis. Overall 14 breasts bearing a malignant lesion, 8 breasts bearing a benign lesion and 3 healthy breasts were analyzed.


RESULTS
The cut-off-based PTA analysis allowed correct detection for 12 of 14 malignant lesions (tumor size: 8 - 80 mm; sensitivity = 85.7 %). Two malignant lesions were missed. In the benign study group only one fibroadenoma was detected (specificity = 87.5 %). The PTA values differed significantly between the benign group and the malignant group (Mann-Whitney U-test, p < 0.05). Breasts with malignant lesions showed higher peaks at early time-points in ICG perfusion.


CONCLUSION
Early perfusion analysis of ICG-enhanced 3D fast optical mammography revealed different enhancement patterns for benign and malignant lesions. This approach might help with the detection of malignant breast lesions and the differentiation from benign lesions.
The risk for a cruciate ligament injury of the knee in adolescents and young adults: a population-based cohort study of 46 500 people with a 9 year follow-up.

OBJECTIVES
The knee joint is the most common site for injury among younger people, the injury often resulting in expensive (surgical) treatment, long-term rehabilitation and permanent functional impairment and disability.


METHODS
We investigated the incidence and risk factors for a major knee-ligament injury in an adolescent Finnish population. A population-based cohort of 46 472 adolescents was followed for an average of 9 years. All patients hospitalised with the diagnosis of anterior or posterior cruciate ligament injury (ACL or PCL injury) were included in the analysis.


RESULTS
265 (0.6%) people (194 male and 71 female subjects) from the total cohort of 46 472 were treated for a cruciate ligament injury of the knee during the follow-up period, giving an injury incidence of 60.9 (95% CI 53.6 to 68.2) per 100 000 person-years. When the socioeconomic, health and lifestyle background variables were taken into account, the adjusted hazard ratio for a cruciate ligament injury of the knee was 8.5 (95% CI 4.3 to 16.4) for female and 4.0 (95% CI 2.7 to 6.1) for male subjects who participated in organised sports > or =4 times/week.


CONCLUSIONS
The general risk for a cruciate ligament injury of the knee is relatively low among adolescents and young adults, but participation in organised sports increases the risk significantly. The risk is especially high in active young women. Preventive measures should be adopted to decrease the short-term and long-term burden of these severe injuries.
Space and Memory in Children＇s Constitution： Approaches to School Cartography

In a globalized world, it is increasingly necessary to study the regional and local identities in order to promote their recovery and educating citizens active in all spatial scales. This study conducts a discussion where approaches to memory with spatial representations made by elementary school students in the city of Jaguariaíva, Paraná, Brazil. Cultural identities are treated as meaning production instance about the living spaces. The relations between formal education, especially the curriculum selected by school geography, and the knowledge of lived experience, can contribute to the study of the references and spatial horizons of residents of urban and rural regions. This perspective is proposed as discussion that aims to contribute to the advancement of reflections on the relationship between school mapping and the production of sense of belonging to different locations.
Fast Variants of RSA

We survey four variants of RSA designed to speed up RSA decryption and signing. We only consider variants that are backwards compatible in the sense that a system using one of these variants can interoperate with systems using standard RSA.
Subscription fraud prevention in telecommunications using fuzzy rules and neural networks

A system to prevent subscription fraud in fixed telecommunications with high impact on long-distance carriers is proposed. The system consists of a classification module and a prediction module. The classification module classifies subscribers according to their previous historical behavior into four different categories: subscription fraudulent, otherwise fraudulent, insolvent and normal. The prediction module allows us to identify potential fraudulent customers at the time of subscription. The classification module was implemented using fuzzy rules. It was applied to a database containing information of over 10,000 real subscribers of a major telecom company in Chile. In this database, a subscription fraud prevalence of 2.2% was found. The prediction module was implemented as a multilayer perceptron neural network. It was able to identify 56.2% of the true fraudsters, screening only 3.5% of all the subscribers in the test set. This study shows the feasibility of significantly preventing subscription fraud in telecommunications by analyzing the application information and the customer antecedents at the time of application. q 2005 Elsevier Ltd. All rights reserved.
“ Real Time Automated Control using PLC-VB Communication ” Prof .

This paper is to enable the Delta PLC (Programmable Logic Control) DVP14SS to communicate with the Visual Basic 6.0. The communication between DVP14SS and Visual Basic 6.0 is via Modbus Serial Protocol. Computers are used as a link between humans and PLC systems as they have more graphics and visual capabilities. These are nothing but SCADA systems widely used for determining plant setups and displaying plant status on high quality screens. They also record/log the system data for long period .The SCADA software's are the software packages needs to be purchased from vendors and the cost depends on tag count. Visual Basic 6.0 platform can be used develop the SCADA application effectively. Using VB 6.0 we integrate software and hardware across spectrum of vendors easily. Here we show simple approach to communicate Delta PLC with visual Basic using MSComm control in visual basic. By means of Visual Basic cost effective solution is possible as Visual Basic we do not need to purchase licenses and is cheaper than SCADA packages. It also has the advantages like flexibility. Keywords—MSComm control and PLC, plc, communication between PLC and VB 6.0, DVP14SS.
The Penn Treebank: An Overview

The Penn Treebank, in its eight years of operation (1989-1996), produced approximately 7 million words of part-of-speech tagged text, 3 million words of skeletally parsed text, over 2 million words of text parsed for predicateargument structure, and 1.6 million words of transcribed spoken text annotated for speech disfluencies. This paper describes the design of the three annotation schemes used by the Treebank: POS tagging, syntactic bracketing, and disfluency annotation and the methodology employed in production. All available Penn Treebank materials are distributed by the Linguistic Data Consortium http://www.ldc.upenn.edu.