LLukas22/scidocs huggingface dataset:
Genotypes and Haplotypes of the Estrogen Receptor α Gene (ESR1) Are Associated With Female-to-Male Gender Dysphoria.

INTRODUCTION
Gender dysphoria, a marked incongruence between one's experienced gender and biological sex, is commonly believed to arise from discrepant cerebral and genital sexual differentiation. With the discovery that estrogen receptor β is associated with female-to-male (FtM) but not with male-to-female (MtF) gender dysphoria, and given estrogen receptor α involvement in central nervous system masculinization, it was hypothesized that estrogen receptor α, encoded by the ESR1 gene, also might be implicated.


AIM
To investigate whether ESR1 polymorphisms (TA)n-rs3138774, PvuII-rs2234693, and XbaI-rs9340799 and their haplotypes are associated with gender dysphoria in adults.


METHODS
Molecular analysis was performed in peripheral blood samples from 183 FtM subjects, 184 MtF subjects, and 394 sex- and ethnically-matched controls.


MAIN OUTCOME MEASURES
Genotype and haplotype analyses of the (TA)n-rs3138774, PvuII-rs2234693, and XbaI-rs9340799 polymorphisms.


RESULTS
Allele and genotype frequencies for the polymorphism XbaI were statistically significant only in FtM vs control XX subjects (P = .021 and P = .020). In XX individuals, the A/G genotype was associated with a low risk of gender dysphoria (odds ratio [OR] = 0.34; 95% CI = 0.16-0.74; P = .011); in XY individuals, the A/A genotype implied a low risk of gender dysphoria (OR = 0.39; 95% CI = 0.17-0.89; P = .008). Binary logistic regression showed partial effects for all three polymorphisms in FtM but not in MtF subjects. The three polymorphisms were in linkage disequilibrium: a small number of TA repeats was linked to the presence of PvuII and XbaI restriction sites (haplotype S-T-A), and a large number of TA repeats was linked to the absence of these restriction sites (haplotype L-C-G). In XX individuals, the presence of haplotype L-C-G carried a low risk of gender dysphoria (OR = 0.66; 95% CI = 0.44-0.99; P = .046), whereas the presence of haplotype L-C-A carried a high susceptibility to gender dysphoria (OR = 3.96; 95% CI = 1.04-15.02; P = .044). Global haplotype was associated with FtM gender dysphoria (P = .017) but not with MtF gender dysphoria.


CONCLUSIONS
XbaI-rs9340799 is involved in FtM gender dysphoria in adults. Our findings suggest different genetic programs for gender dysphoria in men and women. Cortés-Cortés J, Fernández R, Teijeiro N, et al. Genotypes and Haplotypes of the Estrogen Receptor α Gene (ESR1) Are Associated With Female-to-Male Gender Dysphoria. J Sex Med 2017;14:464-472.
Fundamentals of Scatter Search and Path Relinking

The evolutionary approach called Scatter Search, and its generalized form called Path Relinking, have proved unusually effective for solving a diverse array of optimization problems from both classical and real world settings. Scatter Search and Path Relinking differ from other evolutionary procedures, such as genetic algorithms, by providing unifying principles for joining solutions based on generalized path constructions (in both Euclidean and neighborhood spaces) and by utilizing strategic designs where other approaches resort to randomization. Scatter Search and Path Relinking are also intimately related to the Tabu Search metaheuristic, and derive additional advantages by making use of adaptive memory and associated memory-exploiting mechanisms that are capable of being adapted to particular contexts. We describe the features of Scatter Search and Path Relinking that set them apart from other evolutionary approaches, and that offer opportunities for creating increasingly more versatile and effective methods in the future. † Partially supported by the visiting professor fellowship program of the University of Valencia (Grant Ref. No. 42743).
Convolutional Encoders for Neural Machine Translation

We propose a general Convolutional Neural Network (CNN) encoder model for machine translation that fits within in the framework of Encoder-Decoder models proposed by Cho, et. al. [1]. A CNN takes as input a sentence in the source language, performs multiple convolution and pooling operations, and uses a fully connected layer to produce a fixed-length encoding of the sentence as input to a Recurrent Neural Network decoder (using GRUs or LSTMs). The decoder, encoder, and word embeddings are jointly trained to maximize the conditional probability of the target sentence given the source sentence. Many variations on the basic model are possible and can improve the performance of the model.
Online hotel booking : The effects of brand image , price , trust and value on purchase intentions

Leisure travelers increasingly prefer to book hotel online when considering the convenience and cost/ time saving. This research examines the direct and mediating effects of brand image, perceived price, trust, perceived value on consumers' booking intentions and compares the gender differences in online hotel booking. The outcomes confirm most of the direct and indirect path effects and are consistent with findings from previous studies. Consumers in Taiwan tend to believe the hotel price is affordable, the hotel brand is attractive, the hotel is trustworthy, the hotel will offer good value for the price and the likelihood of their booking intentions is high. Brand image, perceived price, and perceived value are the three critical determinants directly influencing purchase intentions. However, the impact of trust on purchase intentions is not significant. The differences between males and females on purchase intentions are not significant as well. Managerial implications of these results are discussed. © 2015 College of Management, National Cheng Kung University. Production and hosting by Elsevier Taiwan LLC. All rights reserved.
Fault-tolerant techniques for the Internet of Military Things

Some obtained results related to an ongoing project which aims at providing a comprehensive approach for implementation of Internet of Things concept into the military domain are presented. A comprehensive approach to fault diagnosis within the Internet of Military Things was outlined. Particularly a method of fault detection which is based on a network partitioning into clusters was proposed. Also, some solutions proposed for the experimentally constructed network called EFTSN was conducted.
Do geographically isolated wetlands influence landscape functions?

Geographically isolated wetlands (GIWs), those surrounded by uplands, exchange materials, energy, and organisms with other elements in hydrological and habitat networks, contributing to landscape functions, such as flow generation, nutrient and sediment retention, and biodiversity support. GIWs constitute most of the wetlands in many North American landscapes, provide a disproportionately large fraction of wetland edges where many functions are enhanced, and form complexes with other water bodies to create spatial and temporal heterogeneity in the timing, flow paths, and magnitude of network connectivity. These attributes signal a critical role for GIWs in sustaining a portfolio of landscape functions, but legal protections remain weak despite preferential loss from many landscapes. GIWs lack persistent surface water connections, but this condition does not imply the absence of hydrological, biogeochemical, and biological exchanges with nearby and downstream waters. Although hydrological and biogeochemical connectivity is often episodic or slow (e.g., via groundwater), hydrologic continuity and limited evaporative solute enrichment suggest both flow generation and solute and sediment retention. Similarly, whereas biological connectivity usually requires overland dispersal, numerous organisms, including many rare or threatened species, use both GIWs and downstream waters at different times or life stages, suggesting that GIWs are critical elements of landscape habitat mosaics. Indeed, weaker hydrologic connectivity with downstream waters and constrained biological connectivity with other landscape elements are precisely what enhances some GIW functions and enables others. Based on analysis of wetland geography and synthesis of wetland functions, we argue that sustaining landscape functions requires conserving the entire continuum of wetland connectivity, including GIWs.
Implementing a Policy and Protocol on Managing Patients With Hypertensive Urgencies.

BACKGROUND
The use of short-acting agents, such as clonidine, for hypertensive urgency has been shown to worsen outcomes and, therefore, should be avoided in the office.


OBJECTIVES
The primary objective was to achieve decreased rates of clonidine orders for immediate treatment of asymptomatic hypertension in the office. The secondary objective was to determine if reduced use leads to a decline in poor outcomes.


METHODS
This was an observational cohort study evaluating a protocol and algorithm developed by clinical pharmacists on the appropriate management of hypertensive urgencies. The protocol included the provision of avoiding short-acting antihypertensives (ie, clonidine). Preintervention and postintervention reports were generated to determine the number of times clonidine was ordered in the office. Electronic health charts were also reviewed for documentation of poor outcomes related to clonidine administration within 1 week of the hypertensive urgency visit date.


RESULTS
In the preintervention cohort, 106 (17.4%) orders of clonidine were captured compared with 73 (10.6%) in the postintervention group (P = 0.001). Of the patients who were administered clonidine, 7 patients in the preintervention group were advised to go to the emergency department (ED) for additional hypertensive management, 2 of whom were subsequently hospitalized; 9 patients were advised to go to the ED in the postintervention group, and no patient was subsequently hospitalized. No adverse effects were documented from in-office clonidine administration in either cohort of patients.


CONCLUSION
The hypertensive urgency protocol and education reduced the number of clonidine orders and hospital admissions. The increase in ED referrals needs further assessment.
The interaction of male and female reproductive strategies and paternity in wild Japanese macaques, Macaca fuscata

Japanese macaques reside in large, mixed-sex social groups in which various reproductive strategies of both sexes operate simultaneously. This report represents the first study combining behavioural and genetic data to examine the interaction of male and female reproductive strategies in primates (N=15 adult males, N=15 adult females, Yakushima Island, Japan). During one mating season, socially dominant males monopolized most female matings. Furthermore, the six offspring sired by troop males were more likely sired by higher-ranking males than lower-ranking males. Nontroop males sired three additional offspring in the troop. Lower-ranking troop males avoided direct competition with higher-ranking males by engaging in sneak copulations with females outside of the presence of other males. Also, females expressed mate choice behaviour towards multiple males of various dominance ranks. Thus, the female strategy of attempting to mate with multiple males conflicted with the mate-guarding strategy of high-ranking males. Despite some female mate choice for midand low-ranking males and alternative male mating tactics by subordinate males, high-ranking males were able to monopolize most, but not all, within-troop mating and paternity. This result was due in part to the low number of females mating at the same time. The mean number of females displaying mating behaviour per day was 2.42 (range 1–5), and higher-ranking males more successfully monopolized females on days when fewer females were mating. The number of females mating simultaneously influences the outcome of reproductive conflicts between the sexes.
Maladaptive behaviors of children with autism: parent support, stress, and coping.

BACKGROUND
The estimated prevalence of Autism Spectrum Disorder (ASD) is one in 88. Autism Spectrum Disorders are nearly five times more common among boys than girls. Children with autism may develop a variety of socially unacceptable maladaptive behaviors beyond the defining symptoms of the spectrum disorder.


AIMS
It is necessary to conduct research to examine maladaptive behaviors of children with autism, family supports, parental stress, and parental coping.


METHODS
Data used were collected during an earlier descriptive, correlational, cross-sectional study. Using the Double ABCX Model of family behavior as the framework, this study evaluated parents' views of the adaptive behaviors of their children diagnosed with autism using the networks of support for their family, parental stress, and parental coping patterns.


RESULTS
Results indicate an association between increased Internalizing maladaptive behaviors and increased parental stress (r = .547, p = .000).


CONCLUSIONS
The findings of this study suggest that parents of children with autism report that their children have clinically significant maladaptive behaviors. Healthcare providers could use results from this study to provide appropriate intervention for maladaptive behaviors to support children with autism and their families.
The Cyclical Dynamics of Illiquid Housing, Debt, and Foreclosures

This paper quantitatively accounts for the cyclical dynamics of key macroeconomic housing and mortgage market variables using a tractable, search-theoretic model of housing with equilibrium mortgage default. To explain these dynamics, the model highlights the importance of liquidity spirals which arise from the interaction of search frictions and endogenous credit constraints. During housing busts, longer selling times spill over into higher foreclosure risk, thereby magnifying the response of credit constraints to the depressed housing market. This contraction in credit then deepens the downturn. During booms, the reverse occurs. Based on these insights, I consider a foreclosure reform that makes all mortgages full recourse, and I show that implementing such a reform would reduce foreclosures and dampen housing dynamics.
Carbon nanotube electronics

We briefly review the electronic properties of carbon nanotubes (CNTs) and present results on the fabrication and characteristics of carbon nanotube field-effect transistors (CNTFETs) and simple integrated circuits. A novel approach allowing the catalyst-free synthesis of oriented CNTs is also presented.
A Set-Partitioning-Based Model for the Stochastic Vehicle Routing Problem

The objective of the Vehicle Routing Problem (VRP) is to construct a minimum cost set of vehicle routes that visits all customers and satisfies demands without violating the vehicle capacity constraints. The Stochastic Vehicle Routing Problem (SVRP) results when one or more elements of the VRP are modeled as random variables. In this paper, we present a set-partitioning-based modeling framework for the VRP with stochastic demands (VRPSD). The framework can be adapted easily for routing problems with randomness in other problem elements, such as random customers and random travel times. We formulate the VRPSD as a two-stage stochastic program and introduce an extended recourse strategy in which vehicles are allowed to serve additional customers from failed routes prior to returning to the depot or to serve customers from failed routes on a new route after returning to the depot. Computational experiments show that route plans generated using the new recourse function perform quite well, especially for problems with few customers per route, where cost savings of roughly 5% are possible.
Sound-Colour Synaesthesia: to What Extent Does it Use Cross-Modal Mechanisms Common to us All?

This study examines a group of synaesthetes who report colour sensations in response to music and other sounds. Experiment 1 shows that synaesthetes choose more precise colours and are more internally consistent in their choice of colours given a set of sounds of varying pitch, timbre and composition (single notes or dyads) relative to a group of controls. In spite of this difference, both controls and synaesthetes appear to use the same heuristics for matching between auditory and visual domains (e.g., pitch to lightness). We take this as evidence that synaesthesia may recruit some of the mechanisms used in normal cross-modal perception. Experiment 2 establishes that synaesthetic colours are automatically elicited insofar as they give rise to cross-modal Stroop interference. Experiment 3 uses a variant of the cross-modal Posner paradigm in which detection of a lateralised target is enhanced when combined with a non-informative but synaesthetically congruent sound-colour pairing. This suggests that synaesthesia uses the same (or an analogous) mechanism of exogenous cross-modal orienting as normal perception. Overall, the results support the conclusion that this form of synaesthesia recruits some of the same mechanisms used in normal cross-modal perception rather than using direct, privileged pathways between unimodal auditory and unimodal visual areas that are absent in most other adults.
Neoclassical vs. Endogenous Growth Analysis: An Overview

A fter a long period of quiescence, growth economics has in the last decade (1986–1995) become an extremely active area of research— both theoretical and empirical.1 To appreciate recent developments and understand associated controversies, it is necessary to place them in context, i.e., in relation to the corpus of growth theory that existed prior to this current burst of activity. This article’s exposition will begin, then, by reviewing in Sections 1–4 the neoclassical growth model that prevailed as of 1985. Once that has been accomplished, in Section 5 we shall compare some crucial implications of the neoclassical model with empirical evidence. After tentatively concluding that the neoclassical setup is unsatisfactory in several important respects, we shall then briefly describe a family of “endogenous growth” models and consider controversies regarding these two classes of theories. Much of this exposition, which is presented in Sections 6–8, will be conducted in the context of a special-case example that permits an exact analytical solution so that explicit
How long should Atrovent be given in acute asthma?

BACKGROUND
In acute asthma the optimal duration of treatment with combination beta agonist and anticholinergic nebuliser solutions is unknown; most studies have investigated single doses or treatment for up to 12 hours. To determine whether longer treatment with ipratropium bromide might aid recovery a study was undertaken in 106 patients with acute asthma.


METHODS
A double blind, randomised, placebo controlled, three group study was performed with all patients receiving ipratropium for 12 hours and salbutamol for 60 hours after admission (both nebulised four hourly), systemic steroids and, if necessary, theophylline. At 12 hours ipratropium was stopped in group I (n = 35) but was continued in the other two groups, and at 36 hours ipratropium was also stopped in group II (n = 35) while patients in group III (n = 36) continued with ipratropium for 60 hours. Spirometric tests were performed before and after salbutamol, and again 30 and 60 minutes after ipratropium or placebo at 12, 36 and 60 hours. Peak flow rates (PEFR) were measured before and after each nebulisation.


RESULTS
There were no differences between the groups in PEFR on admission (group I: 214 l/min, group II: 198 l/min, group III: 221 l/min), or mean forced expiratory volume in one second (FEV1) at 12 hours (group I: 1.81, group II: 2.01, group III: 2.21), 36 hours (group I: 2.11, group II: 2.31, group III: 2.41), or at 60 hours (group I: 2.21, group II: 2.31, group III 2.51). Despite this, median time to discharge was significantly higher for patients in group I (5.4 days) than for those in groups II (4.1 days) and III (4.0 days).


CONCLUSIONS
Combination nebulised therapy can be continued beyond 12 hours and up to 36 hours after admission with improved recovery time. Lung function testing may not reflect the full benefit of treatment.
Effect of two intensive statin regimens on progression of coronary disease.

BACKGROUND
Statins reduce adverse cardiovascular outcomes and slow the progression of coronary atherosclerosis in proportion to their ability to reduce low-density lipoprotein (LDL) cholesterol. However, few studies have either assessed the ability of intensive statin treatments to achieve disease regression or compared alternative approaches to maximal statin administration.


METHODS
We performed serial intravascular ultrasonography in 1039 patients with coronary disease, at baseline and after 104 weeks of treatment with either atorvastatin, 80 mg daily, or rosuvastatin, 40 mg daily, to compare the effect of these two intensive statin regimens on the progression of coronary atherosclerosis, as well as to assess their safety and side-effect profiles.


RESULTS
After 104 weeks of therapy, the rosuvastatin group had lower levels of LDL cholesterol than the atorvastatin group (62.6 vs. 70.2 mg per deciliter [1.62 vs. 1.82 mmol per liter], P<0.001), and higher levels of high-density lipoprotein (HDL) cholesterol (50.4 vs. 48.6 mg per deciliter [1.30 vs. 1.26 mmol per liter], P=0.01). The primary efficacy end point, percent atheroma volume (PAV), decreased by 0.99% (95% confidence interval [CI], -1.19 to -0.63) with atorvastatin and by 1.22% (95% CI, -1.52 to -0.90) with rosuvastatin (P=0.17). The effect on the secondary efficacy end point, normalized total atheroma volume (TAV), was more favorable with rosuvastatin than with atorvastatin: -6.39 mm(3) (95% CI, -7.52 to -5.12), as compared with -4.42 mm(3) (95% CI, -5.98 to -3.26) (P=0.01). Both agents induced regression in the majority of patients: 63.2% with atorvastatin and 68.5% with rosuvastatin for PAV (P=0.07) and 64.7% and 71.3%, respectively, for TAV (P=0.02). Both agents had acceptable side-effect profiles, with a low incidence of laboratory abnormalities and cardiovascular events.


CONCLUSIONS
Maximal doses of rosuvastatin and atorvastatin resulted in significant regression of coronary atherosclerosis. Despite the lower level of LDL cholesterol and the higher level of HDL cholesterol achieved with rosuvastatin, a similar degree of regression of PAV was observed in the two treatment groups. (Funded by AstraZeneca Pharmaceuticals; ClinicalTrials.gov number, NCT000620542.).