LLukas22/scidocs huggingface dataset:
Treatment with oestrogen or manual separation for labial adhesions – initial outcome and long-term follow-up

BACKGROUND
Topical oestrogen and manual separation are the main treatments for labial adhesions. The aim was to evaluate treatment of labial adhesions and compare the outcome of topical oestrogen treatment with that of manual separation.


METHOD
All girls aged 0-12 years admitted to a tertiary centre for paediatric surgery for labial adhesions were included. The study design was dual: The first part was a retrospective chart review of the treatment success according to the medical charts. The second part was a cross-sectional parent-reported long-term outcome study (> 6 months after last treatment finished).


RESULTS
In total 71 patients were included and the median follow-up time for the chart study was 84 (6-162) months after treatment with oestrogen or manual separation. Oestrogen was the first treatment for 66 patients who had an initial successful rate of 62% but this was followed by recurrences in 44%. Five patients had manual treatment as their first treatment and they had a 100% initial success rate followed by recurrences in 20%. Therefore, for the first treatment course there was a final success rate of 35% for oestrogen and 80% for manual separation (p = 0.006). Corresponding final success rates including all consecutive treatments over the study period were 46/130 (35%) for oestrogen and 21/30 (70%) for manual separation (p = 0.001). The success rate for oestrogen did not differ if treatment was given in a course length of 0-4 weeks (39% success) or > 4 weeks (32% success) (p = 0.369). In the parent-reported long-term outcome study the response rate was 51% (36/71). Parents reported that recurrences of adhesions after last prescribed/performed treatment were frequent: in total 25% of patients still had adhesions corresponding to 8/29 (29%) of those whose last treatment was oestrogen and 1/9 (11%) of those whose last treatment was manual separation.


CONCLUSION
Due to the results recurrences are common after both oestrogen and manual separations. However, the overall final outcome after manual separation seems to be more successful when compared to that of topical oestrogen treatment.
Deep Learning for the Internet of Things

How can the advantages of deep learning be brought to the emerging world of embedded IoT devices? The authors discuss several core challenges in embedded and mobile deep learning, as well as recent solutions demonstrating the feasibility of building IoT applications that are powered by effective, efficient, and reliable deep learning models.
Wearable Intelligent Systems for E-Health

Due to the increasingly aging population, there is a rising demand for assistive living technologies for the elderly to ensure their health and well-being. The elderly are mostly chronic patients who require frequent check-ups of multiple vital signs, some of which (e.g., blood pressure and blood glucose) vary greatly according to the daily activities that the elderly are involved in. Therefore, the development of novel wearable intelligent systems to effectively monitor the vital signs continuously over a 24 hour period is in some cases crucial for understanding the progression of chronic symptoms in the elderly. In this paper, recent development of Wearable Intelligent Systems for e-Health (WISEs) is reviewed, including breakthrough technologies and technical challenges that remain to be solved. A novel application of wearable technologies for transient cardiovascular monitoring during water drinking is also reported. In particular, our latest results found that heart rate increased by 9 bpm (P < 0.001) and pulse transit time was reduced by 5 ms (P < 0.001), indicating a possible rise in blood pressure, during swallowing. In addition to monitoring physiological conditions during daily activities, it is anticipated that WISEs will have a number of other potentially viable applications, including the real-time risk prediction of sudden cardiovascular events and deaths. Category: Smart and intelligent computing
Effects of Ramadan Fasting on Body Composition, Aerobic Performance and Lactate, Heart Rate and Perceptual Responses in Young Soccer Players

The purpose of this study was to examine the effects of Ramadan fasting on body composition, aerobic exercise performance and blood lactate, heart rate and perceived exertion in regularly trained young soccer players. Sixteen male soccer players participated in this study. Mean age, stature, body mass and training age of the players were 17.4±1.2 years, 175.4±3.6 cm, 69.6±4.3 kg and 5.1±1.3 years, respectively. During the Ramadan period, all subjects voluntarily chose to follow the fasting guidelines and abstained from eating and drinking from sunrise to sunset. Body composition, hydration status, dietary intake and sleep duration were assessed on four occasions: before Ramadan, at the beginning of Ramadan, at the end of Ramadan and 2 weeks after the end of Ramadan. On each occasion, aerobic exercise performance and blood lactate, heart rate and rating of perceived exertion responses of players were also determined during an incremental running test. Repeated measures of ANOVA revealed that body mass, percentage of body fat, fat-free mass, hydration status, daily sleeping time and daily energy and macronutrient intake of players did not vary significantly throughout the study period (p>0.05). However, players experienced a small but significant decrease in skinfold thicknesses over the course of the study (p<0.05). Although ratings of perceived exertion at submaximal workloads increased during Ramadan (p<0.05), blood lactate and heart rate responses had decreased by the end of Ramadan (p<0.05). In line with these changes, peak running performance and running velocity at anaerobic threshold also improved by the end of Ramadan (p<0.05). Improvements in aerobic exercise performance with time were probably due to the effects of pre-season training program that was performed after the break of the fast (Iftar) during the month of Ramadan. The results of the present study suggest that if regular training regimen, body fluid balance, daily energy intake and sleep duration are maintained as before Ramadan, Ramadan fasting does not have detrimental effects on aerobic exercise performance or body composition in young soccer players.
Sub-threshold frequency doubled Nd. YAG modified mild maculr grid laser for diffuse diabetic maculopathy.

OBJECTIVE
To determine the anatomical and functional improvement in eyes with diffuse macular oedema after modified mild macular grid laser.


METHODS
The prospective study was conducted at the Department of Ophthalmology Unit II, Civil Hospital Karachi, and the Department of Ophthalmology, Dow International Medical College, Karachi, from June 2011 to May 2014. We used neodymium-doped yttrium aluminium garnet 532nm frequency-doubled green laser to treat all eligible patients. Treatment variables were a spot size of 50 microns, exposure duration of 0.1 seconds, and power sufficient to produce barely visible burns in a grid pattern. We treated the thickened retina and non-thickened area of the macula excluding central 500 micron. Microaneurysms within the macular areas were treated by focal application of laser shots sufficient to bleach them.


RESULTS
The study comprised 86 eyes of 52 patients who were treated by applying 180 to 360 burns with a mean of 275±51. Mean macular thickness differed significantly between time points (Wilks' Lambda 0.139; F (2, 6) = 125.95; p = 0.00001). Mean visual acuity changed significantly between time points (Wilks' Lambda 0.535; F (4, 82) = 17.8; p = 0.00001). At the last follow-up, visual acuity improved at least one line in 32(37.2%) eyes, remained stable in 48(55.8%) eyes, and declined in 6(6.9%) eyes.


CONCLUSIONS
Modified mild macular grid is an effective and safe procedure for patients with diffuse diabetic macular oedema.
INCLEN Diagnostic Tool for Autism Spectrum Disorder (INDT-ASD): development and validation.

OBJECTIVE
To develop and validate INCLEN Diagnostic Tool for Autism Spectrum Disorder (INDT-ASD).


DESIGN
Diagnostic test evaluation by cross sectional design.


SETTING
Four tertiary pediatric neurology centers in Delhi and Thiruvanthapuram, India.


METHODS
Children aged 2-9 years were enrolled in the study. INDT-ASD and Childhood Autism Rating Scale (CARS) were administered in a randomly decided sequence by trained psychologist, followed by an expert evaluation by DSM-IV TR diagnostic criteria (gold standard).


MAIN OUTCOME MEASURES
Psychometric parameters of diagnostic accuracy, validity (construct, criterion and convergent) and internal consistency.


RESULTS
154 children (110 boys, mean age 64.2 mo) were enrolled. The overall diagnostic accuracy (AUC=0.97, 95% CI 0.93, 0.99; P<0.001) and validity (sensitivity 98%, specificity 95%, positive predictive value 91%, negative predictive value 99%) of INDT-ASD for Autism spectrum disorder were high, taking expert diagnosis using DSM-IV-TR as gold standard. The concordance rate between the INDT-ASD and expert diagnosis for 'ASD group' was 82.52% [Cohen's k=0.89; 95% CI (0.82, 0.97); P=0.001]. The internal consistency of INDT-ASD was 0.96. The convergent validity with CARS (r = 0.73, P= 0.001) and divergent validity with Binet-Kamat Test of intelligence (r = -0.37; P=0.004) were significantly high. INDT-ASD has a 4-factor structure explaining 85.3% of the variance.


CONCLUSIONS
INDT-ASD has high diagnostic accuracy, adequate content validity, good internal consistency high criterion validity and high to moderate convergent validity and 4-factor construct validity for diagnosis of Autistm spectrum disorder.
Ledipasvir and sofosbuvir for 8 or 12 weeks for chronic HCV without cirrhosis.

BACKGROUND
High rates of sustained virologic response were observed among patients with hepatitis C virus (HCV) infection who received 12 weeks of treatment with the nucleotide polymerase inhibitor sofosbuvir combined with the NS5A inhibitor ledipasvir. This study examined 8 weeks of treatment with this regimen.


METHODS
In this phase 3, open-label study, we randomly assigned 647 previously untreated patients with HCV genotype 1 infection without cirrhosis to receive ledipasvir and sofosbuvir (ledipasvir-sofosbuvir) for 8 weeks, ledipasvir-sofosbuvir plus ribavirin for 8 weeks, or ledipasvir-sofosbuvir for 12 weeks. The primary end point was sustained virologic response at 12 weeks after the end of therapy.


RESULTS
The rate of sustained virologic response was 94% (95% confidence interval [CI], 90 to 97) with 8 weeks of ledipasvir-sofosbuvir, 93% (95% CI, 89 to 96) with 8 weeks of ledipasvir-sofosbuvir plus ribavirin, and 95% (95% CI, 92 to 98) with 12 weeks of ledipasvir-sofosbuvir. As compared with the rate of sustained virologic response in the group that received 8 weeks of ledipasvir-sofosbuvir, the rate in the 12-week group was 1 percentage point higher (97.5% CI, -4 to 6) and the rate in the group that received 8 weeks of ledipasvir-sofosbuvir with ribavirin was 1 percentage point lower (95% CI, -6 to 4); these results indicated noninferiority of the 8-week ledipasvir-sofosbuvir regimen, on the basis of a noninferiority margin of 12 percentage points. Adverse events were more common in the group that received ribavirin than in the other two groups. No patient who received 8 weeks of only ledipasvir-sofosbuvir discontinued treatment owing to adverse events.


CONCLUSIONS
Ledipasvir-sofosbuvir for 8 weeks was associated with a high rate of sustained virologic response among previously untreated patients with HCV genotype 1 infection without cirrhosis. No additional benefit was associated with the inclusion of ribavirin in the regimen or with extension of the duration of treatment to 12 weeks. (Funded by Gilead Sciences; ION-3 ClinicalTrials.gov number, NCT01851330.).
Efficacy of gait training using a treadmill with and without visual biofeedback in patients after stroke: A randomized study.

OBJECTIVES
To evaluate the effects of gait training using a treadmill with and without visual biofeedback in patients in the late period after stroke, and to compare both training methods.


DESIGN
A randomized, controlled study.


SUBJECTS
Fifty people at least 6 months after stroke, randomly enrolled into groups with a rehabilitation programme of treadmill training with or without visual biofeedback.


METHODS
Spatio-temporal gait parameters, walking speed, walking distance, self-reliant mobility and functional capacity were evaluated during a programme of 10 sessions over 2 weeks.


RESULTS
Patients in both groups achieved statistically significant improvement. Participants in the intervention group revealed a significantly greater improvement in the shortening of the stance phase (p = 0.0045) and lengthening of the swing phase of the unaffected limb (p = 0.0042) and an increase in the unaffected limb cycle length (p = 0.0021). There were no significant differences between groups in other spatio-temporal parameters of gait or additionally assessed parameters.


CONCLUSION
Gait training using a treadmill resulted in improvements in the gait and functional capacity of patients. The use of biofeedback gives better results in improving gait cycle length, duration of gait phases and swing phase speed compared with exercise on a treadmill alone.
Lactobacillus rhamnosus administration causes sepsis in a cardiosurgical patient--is the time right to revise probiotic safety guidelines?

A 24-year-old female patient developed sepsis resulting from preoperative administration of probiotics following an aortic valve replacement. Blood cultures revealed the causative agent to be the probiotic Lactobacillus rhamnosus, which has recently been implicated as an emerging aetiology of infection in those taking probiotics. In the past few years, probiotic use in hospitals has increased greatly. However, there is growing global evidence that the use of probiotics in patients with organ failure, immunocompromised status and dysfunctional gut barrier mechanisms can cause infections. This and other reports show the importance of establishing generally recognized safety guidelines.
Efficacy and safety of canagliflozin over 52 weeks in patients with type 2 diabetes on background metformin and pioglitazone

AIM
The efficacy and safety of canagliflozin, a sodium glucose co-transporter 2 inhibitor, was evaluated in patients with type 2 diabetes mellitus (T2DM) inadequately controlled with metformin and pioglitazone.


METHODS
In this randomized, double-blind, phase 3 study, patients (N = 342) received canagliflozin 100 or 300 mg during a 26-week, placebo-controlled, core period and a 26-week, active-controlled extension in which placebo-treated patients were switched to sitagliptin 100 mg. Efficacy comparisons for canagliflozin versus placebo at week 26 are reported, with no comparisons versus sitagliptin at week 52 (sitagliptin used to maintain double-blind and control for safety). Safety data are reported for canagliflozin and placebo/sitagliptin.


RESULTS
Canagliflozin 100 and 300 mg significantly lowered haemoglobin A1c (HbA1c) compared with placebo at week 26 (-0.89%, -1.03% and -0.26%; p < 0.001); reductions with canagliflozin 100 and 300 mg were maintained at week 52 (-0.92% and -1.03%). Relative to placebo, both canagliflozin doses significantly reduced body weight (-2.5 and -3.5 kg), fasting plasma glucose and systolic blood pressure (BP) at week 26 (p < 0.05 for all), with reductions maintained at week 52. Overall adverse event (AE) incidence over 52 weeks was 69.9, 76.3 and 76.5% with canagliflozin 100 and 300 mg and placebo/sitagliptin; AE-related discontinuation and serious AE rates were low. Incidences of genital mycotic infections and AEs related to osmotic diuresis and volume depletion were higher with canagliflozin than placebo/sitagliptin.


CONCLUSION
Canagliflozin improved glycaemic control, reduced body weight and systolic BP, and was generally well tolerated in patients with T2DM on metformin and pioglitazone over 52 weeks.
A phase 2 trial of once-weekly hypofractionated breast irradiation: first report of acute toxicity, feasibility, and patient satisfaction.

PURPOSE
To report on early results of a single-institution phase 2 trial of a 5-fraction, once-weekly radiation therapy regimen for patients undergoing breast-conserving surgery (BCS).


METHODS AND MATERIALS
Patients who underwent BCS for American Joint Committee on Cancer stage 0, I, or II breast cancer with negative surgical margins were eligible to receive whole breast radiation therapy to a dose of 30 Gy in 5 weekly fractions of 6 Gy with or without an additional boost. Elective nodal irradiation was not permitted. There were no restrictions on breast size or the use of cytotoxic chemotherapy for otherwise eligible patients. Patients were assessed at baseline, treatment completion, and at first posttreatment follow-up to assess acute toxicity (Common Terminology Criteria for Adverse Events, version 3.0) and quality of life (European Organization for Research and Treatment of Cancer QLQ-BR23).


RESULTS
Between January and September 2011, 42 eligible patients underwent weekly hypofractionated breast irradiation immediately following BCS (69.0%) or at the conclusion of cytotoxic chemotherapy (31.0%). The rates of grade ≥2 radiation-induced dermatitis, pain, fatigue, and breast edema were 19.0%, 11.9%, 9.5%, and 2.4%, respectively. Only 1 grade 3 toxicity-pain requiring a course of narcotic analgesics-was observed. One patient developed a superficial cellulitis (grade 2), which resolved with the use of oral antibiotics. Patient-reported moderate-to-major breast symptoms (pain, swelling, and skin problems), all decreased from baseline through 1 month, whereas breast sensitivity remained stable over the study period.


CONCLUSIONS
The tolerance of weekly hypofractionated breast irradiation compares well with recent reports of daily hypofractionated whole-breast irradiation schedules. The regimen appears feasible and cost-effective. Additional follow-up with continued accrual is needed to assess late toxicity, cosmesis, and disease-specific outcomes.
Favorable outcome after complete resection in elderly soft tissue sarcoma patients: Japanese Musculoskeletal Oncology Group study.

BACKGROUND
The surgical management of soft tissue sarcoma (STS) in elderly patients has only been addressed in a few studies. The objective of the current study was to assess surgical outcomes in patients with STS aged 70 years and older and the association of older age with the survival after complete resection.


METHODS
A retrospective analysis was conducted in 158 elderly patients with localized STS who visited 11 institutions participating in Japanese Musculoskeletal Oncology Group between 1995 and 2006 and were treated by surgical resection. Univariate and multivariate analyses were performed to identify prognostic factors.


RESULTS
Median follow-up period was 38 months. Histologically high-grade tumors were detected in 71% of the patients. Wide resection with adequate margins was performed in 66% of the cases. Systemic chemotherapy was performed in only 5 patients. Univariate analysis identified histological grade and gender as statistically significant prognostic factors for sarcoma-specific survival. Multivariate analysis did not identify significant prognostic factors for sarcoma-specific survival, although high grade sarcoma emerged as a potentially significant prognostic factor (P = 0.050). Local recurrence was detected in 19% of the patients. Multivariate analysis of local recurrence-free survival showed that tumor site and surgical margins were statistically significant prognostic factors.


CONCLUSIONS
Older age was not identified as a prognostic factor for sarcoma-specific survival, which is not consistent with the findings of previous studies showing that older age was associated with decreased sarcoma-specific survival. Complete resection should be indicated and can lead to optimal treatment outcome for properly selected elderly patients.
Selection on Observed and Unobserved Variables: Assessing the Effectiveness of Catholic Schools

In this paper we measure the effect of Catholic high school attendance on educational attainment and test scores. Because we do not have a good instrumental variable for Catholic school attendance, we develop new estimation methods based on the idea that the amount of selection on the observed explanatory variables in a model provides a guide to the amount of selection on the unobservables. We also propose an informal way to assess selectivity bias based on measuring the ratio of selection on unobservables to selection on observables that would be required if one is to attribute the entire effect of Catholic school attendance to selection bias. We use our methods to estimate the effect of attending a Catholic high school on a variety of outcomes. Our main conclusion is that Catholic high schools substantially increase the probability of graduating from high school and, more tentatively, college attendance. We find little evidence of an effect on test scores.
Abductive Plan Recognition by Extending Bayesian Logic Programs

Plan recognition is the task of predicting an agent’s top-level plans based on its observed actions. It is an abductive reasoning task that involves inferring cause from effect. Most existing approaches to plan recognition use either first-order logic or probabilistic graphical models. While the former cannot handle uncertainty, the latter cannot handle structured representations. In order to overcome these limitations, we develop an approach to plan recognition using Bayesian Logic Programs (BLPs), which combine first-order logic and Bayesian networks. Since BLPs employ logical deduction to construct the networks, they cannot be used effectively for plan recognition. Therefore, we extend BLPs to use logical abduction to construct Bayesian networks and call the resulting model Bayesian Abductive Logic Programs (BALPs). We learn the parameters in BALPs using the Expectation Maximization algorithm adapted for BLPs. Finally, we present an experimental evaluation of BALPs on three benchmark data sets and compare its performance with the state-of-the-art for plan recogni-
A Unified Formalization of Four Shared-Memory Models

This paper presents a shared-memory model, data-race-free-1, that unifies four earlier models: weak ordering, release consistency (with sequentially consistent special operations), the VAX memory model, and datarace-free-0. The most intuitive and commonly assumed shared-memory model, sequential consistency, limits performance. The models of weak ordering, release consistency, the VAX, and data-race-free-0 are based on the common intuition that if programs synchronize explicitly and correctly, then sequential consistency can be guaranteed with high performance. However, each model formalizes this intuition differently and has different advantages and disadvantages with respect to the other models. Data-race-free-1 unifies the models of weak ordering, release consistency, the VAX, and data-race-free-0 by formalizing the above intuition in a manner that retains the advantages of each of the four models. A multiprocessor is data-race-free-1 if it guarantees sequential consistency to data-race-free programs. Data-race-free-1 unifies the four models by providing a programmer’s interface similar to the four models, and by allowing all implementations allowed by the four models. Additionally, data-race-free-1 expresses the programmer’s interface more explicitly and formally than weak ordering and the VAX, and allows an implementation not allowed by weak ordering, release consistency, or data-race-free-0. The new implementation proposal for data-race-free-1 differs from earlier implementations mainly by permitting the execution of all synchronization operations of a processor even while previous data operations of the processor are in progress. To ensure sequential consistency, two synchronizing processors exchange information to delay later operations of the second processor that conflict with an incomplete data operation of the first processor.