LLukas22/scidocs huggingface dataset:
GENERATIVE RESEARCH IN DESIGN EDUCATION

This paper proposes a model of design research used to structure projects in design education, with relevant connections to design practice. Design projects are phased through exploratory, generative, and evaluative sequences of research and design. Generative methods are particularly unique. Participatory and creative codesign toolkits are distinguished by their potential use as projective techniques, allowing participants to project their thoughts, feelings and desires through ambiguous visual stimuli, and as constructive techniques, providing design elements for users to manipulate in guiding concept development. In addition to established techniques, innovative variations have been inspired by the philosophy of generative research. This paper will utilize examples from a university design program to illustrate a model of design research, with an emphasis on generative methods. The model will be critiqued as a structure for projects in design education and practice, including the challenges and opportunities of teaching research methods in a creative design context.
Design of broadband circularly polarized horn antenna using an L-shaped probe

This paper deals with a circular horn antenna fed by an L-shaped probe. The design process for broadband matching to a 50 Omega coaxial cable, and the antenna performance in axial ratio and gain are presented. The simulation results of this paper were obtained using Ansoft HFSS 9.2
Reversible Logic Synthesis of Fault Tolerant Carry Skip BCD Adder

Reversible logic is emerging as an important research area having its application in diverse fields such as low power CMOS design, digital signal processing, cryptography, quantum computing and optical information processing. This paper presents a new 4*4 parity preserving reversible logic gate, IG. The proposed parity preserving reversible gate can be used to synthesize any arbitrary Boolean function. It allows any fault that affects no more than a single signal readily detectable at the circuit’s primary outputs. It is shown that a fault tolerant reversible full adder circuit can be realized using only two IGs. The proposed fault tolerant full adder (FTFA) is used to design other arithmetic logic circuits for which it is used as the fundamental building block. It has also been demonstrated that the proposed design offers less hardware complexity and is efficient in terms of gate count, garbage outputs and constant inputs than the existing counterparts.
A phase I study of quisinostat (JNJ-26481585), an oral hydroxamate histone deacetylase inhibitor with evidence of target modulation and antitumor activity, in patients with advanced solid tumors.

PURPOSE
To determine the maximum-tolerated dose (MTD), dose-limiting toxicities (DLT), and pharmacokinetic and pharmacodynamic profile of quisinostat, a novel hydroxamate, pan-histone deacetylase inhibitor (HDACi).


EXPERIMENTAL DESIGN
In this first-in-human phase I study, quisinostat was administered orally, once daily in three weekly cycles to patients with advanced malignancies, using a two-stage accelerated titration design. Three intermittent schedules were subsequently explored: four days on/three days off; every Monday, Wednesday, Friday (MWF); and every Monday and Thursday (M-Th). Toxicity, pharmacokinetics, pharmacodynamics, and clinical efficacy were evaluated at each schedule.


RESULTS
Ninety-two patients were treated in continuous daily (2-12 mg) and three intermittent dosing schedules (6-19 mg). Treatment-emergent adverse events included: fatigue, nausea, decreased appetite, lethargy, and vomiting. DLTs observed were predominantly cardiovascular, including nonsustained ventricular tachycardia, ST/T-wave abnormalities, and other tachyarhythmias. Noncardiac DLTs were fatigue and abnormal liver function tests. The maximum plasma concentration (Cmax) and area under the plasma concentration-time curve (AUC) of quisinostat increased proportionally with dose. Pharmacodynamic evaluation showed increased acetylated histone 3 in hair follicles, skin and tumor biopsies, and in peripheral blood mononuclear cells as well as decreased Ki67 in skin and tumor biopsies. A partial response lasting five months was seen in one patient with melanoma. Stable disease was seen in eight patients (duration 4-10.5 months).


CONCLUSIONS
The adverse event profile of quisinostat was comparable with that of other HDACi. Intermittent schedules were better tolerated than continuous schedules. On the basis of tolerability, pharmacokinetic predictions, and pharmacodynamic effects, the recommended dose for phase II studies is 12 mg on the MWF schedule.
Study of water ecological restoration and protective development strategy

The theory and technology of water ecological restoration is the development direction and frontier of the contemporary ecology.From actual conditions,the paper scientifically interprets the water ecological system by using the ecology theory and method and annotates the concepts,contents and principles of water ecological restoration.On this basis,the innovative idea is put forward for the water ecological system protection and development strategy,which has the great practical significance and application value.
Restoration of Nickel-Base Turbine Blade Knife-Edges with Controlled Laser Aided Additive Manufacturing

In this paper, restoration of nickel-base turbine blade knife-edges with controlled Laser Aided Additive Manufacturing (LAAM) process was investigated. The alloy contains about 9 weight percent Ti/Al composition, which makes it difficult to repair due to the cracking issue. Infrared temperature signal emitted from melt pool was adopted for process control. The deposition with and without process control was compared. The deposition with process control can avoid the hot-cracking which often occurs during deposition of nickel-base super-alloys. The results showed that the process control can also guarantee a better dimensional accuracy. The microstructure of the deposited layers in the cross-section was examined under both microscope and SEM. It displayed directionally solidified fine columnar dendrites which grew following the change of the heat conduction condition. The EDX line scanning verified that chemical composition remained homogeneous distribution in the deposited thin wall. Spot EDX analysis identified that TiC is most likely the main type of carbides formed at the grain boundaries. The results demonstrated that the LAAM process is feasible for the recondition of the gas turbine blade knife-edges.
Mixture probability distribution functions to model wind speed distributions

Accurate wind speed modeling is critical in estimating wind energy potential for harnessing wind power effectively. The quality of wind speed assessment depends on the capability of chosen probability density function (PDF) to describe the measured wind speed frequency distribution. The objective of this study is to describe (model) wind speed characteristics using three mixture probability density functions Weibull-extreme value distribution (GEV), Weibull-lognormal, and GEV-lognormal which were not tried before. Statistical parameters such as maximum error in the Kolmogorov-Smirnov test, root mean square error, Chi-square error, coefficient of determination, and power density error are considered as judgment criteria to assess the fitness of the probability density functions. Results indicate that Weibull-GEV PDF is able to describe unimodal as well as bimodal wind distributions accurately whereas GEV-lognormal PDF is able to describe familiar bell-shaped unimodal distribution well. Results show that mixture probability functions are better alternatives to conventional Weibull, two-component mixture Weibull, gamma, and lognormal PDFs to describe wind speed characteristics.
Management of Stahl ’ s ear : a case report

Stahl’s ear deformity was first described in the 19th century and it consists of a rare auricular deformity characterized by hypoplasia of the antihelix crus with enlargement of its base and a third crus of the antihelix connected to posterior portion of helix crus, which deforms the posterolateral wall of the external auditory canal. Reconstructive surgery is the definitive treatment, however, because of the diversity of clinical presentations, no standard technique exist for all cases. The method described in this report is another treatment option and entails the resection of the third crus and reconstruction of superior crus of the antihelix. ■ ABSTRACT
A phase I study of the oral platinum agent satraplatin in sequential combination with capecitabine in the treatment of patients with advanced solid malignancies.

BACKGROUND
The broad spectrum of antitumor activity of both the oral platinum analogue satraplatin (S) and capecitabine (C), along with the advantage of their oral administration, prompted a clinical study aimed to define the maximum tolerated dose (MTD) of the combination.


PATIENTS AND METHODS
Four dose levels of S (mg/m(2)/day) and C (mg/m(2)/day) were evaluated in adult patients with advanced solid tumors: 60/1650, 80/1650, 60/2000, 70/2000; a course consisted of 28 days with sequential administration of S (days 1-5) and C (days 8-21) followed by one week rest.


RESULTS
Thirty-seven patients were treated, 24 in the dose escalation and 13 in the expansion phase; at the MTD, defined at S 70/C 2000, two patients presented dose limiting toxicities: lack of recovery of neutropenia by day 42 and nausea with dose skip of C. Most frequent toxicities were nausea (57%), diarrhea (51%), neutropenia (46%), anorexia, fatigue, vomiting (38% each). Two partial responses were observed in platinum sensitive ovarian cancer and one in prostate cancer.


CONCLUSION
At S 70/C 2000 the combination of sequential S and C is tolerated with manageable toxicities; its evaluation in platinum and fluorouracil sensitive tumor types is worthwhile because of the easier administration and lack of nephro- and neurotoxicity as compared to parent compounds.
Incidence of Pre-, Peri-, and Post-Natal Birth and Developmental Problems of Children with Sensory Processing Disorder and Children with Autism Spectrum Disorder

As the diagnosis of sensory processing disorder (SPD) is advanced, it is important to investigate potential contributing factors to this disorder as well as early diagnostic signs. An exploratory descriptive study, utilizing retrospective chart review, was conducted to investigate the incidence of pre-, peri- and post-natal, birth and developmental problems in a sample of 1000 children with SPD and of 467 children with autism spectrum disorder (ASD), who also had SPD. This study revealed that although no one factor was strongly associated with SPD or ASD, an average of seven events for children with SPD and eight events for children with ASD occurred across categories. These included: one pre-natal/pregnancy problem, delivery complication, assisted delivery, gestational or birth-related injury/illness; one or more early childhood illnesses or injuries; two or more infancy/early childhood developmental problems; and one or more delayed early childhood developmental milestones. When comparing results to national studies of the typical population, most remarkable was the incidence of jaundice, three to four times higher in both the SPD and ASD groups than in typical children. In addition, rates of breech position, cord wrap/ prolapse, assisted delivery methods (particularly forceps and suction deliveries), and high birth-weight were greater in both groups. Incidence of premature birth was higher in the ASD although not significantly different from the SPD group. Also of note was a high frequency of absent or brief crawling phase, and high percentages of problems with ear infections, allergies, and maternal stresses during pregnancy.
Effects of combined physical and cognitive training on fitness and neuropsychological outcomes in healthy older adults

PURPOSE
Physical exercise and cognitive training have been shown to enhance cognition among older adults. However, few studies have looked at the potential synergetic effects of combining physical and cognitive training in a single study. Prior trials on combined training have led to interesting yet equivocal results. The aim of this study was to examine the effects of combined physical and cognitive interventions on physical fitness and neuropsychological performance in healthy older adults.


METHODS
Seventy-six participants were randomly assigned to one of four training combinations using a 2×2 factorial design. The physical intervention was a mixed aerobic and resistance training program, and the cognitive intervention was a dual-task (DT) training program. Stretching and toning exercises and computer lessons were used as active control conditions. Physical and cognitive measures were collected pre- and postintervention.


RESULTS
All groups showed equivalent improvements in measures of functional mobility. The aerobic-strength condition led to larger effect size in lower body strength, independently of cognitive training. All groups showed improved speed of processing and inhibition abilities, but only participants who took part in the DT training, independently of physical training, showed increased task-switching abilities. The level of functional mobility after intervention was significantly associated with task-switching abilities.


CONCLUSION
Combined training did not yield synergetic effects. However, DT training did lead to transfer effects on executive performance in neuropsychological tests. Both aerobic-resistance training and stretching-toning exercises can improve functional mobility in older adults.
A study of whether automated Diabetic Retinopathy Image Assessment could replace manual grading steps in the English National Screening Programme.

OBJECTIVES
Diabetic retinopathy screening in England involves labour intensive manual grading of digital retinal images. We present the plan for an observational retrospective study of whether automated systems could replace one or more steps of human grading.


METHODS
Patients aged 12 or older who attended the Diabetes Eye Screening programme, Homerton University Hospital (London) between 1 June 2012 and 4 November 2013 had macular and disc-centred retinal images taken. All screening episodes were manually graded and will additionally be graded by three automated systems. Each system will process all screening episodes, and screening performance (sensitivity, false positive rate, likelihood ratios) and diagnostic accuracy (95% confidence intervals of screening performance measures) will be quantified. A sub-set of gradings will be validated by an approved Reading Centre. Additional analyses will explore the effect of altering thresholds for disease detection within each automated system on screening performance.


RESULTS
2,782/20,258 diabetes patients were referred to ophthalmologists for further examination. Prevalence of maculopathy (M1), pre-proliferative retinopathy (R2), and proliferative retinopathy (R3) were 7.9%, 3.1% and 1.2%, respectively; 4749 (23%) patients were diagnosed with background retinopathy (R1); 1.5% were considered ungradable by human graders.


CONCLUSIONS
Retinopathy prevalence was similar to other English diabetic screening programmes, so findings should be generalizable. The study population size will allow the detection of differences in screening performance between the human and automated grading systems as small as 2%. The project will compare performance and economic costs of manual versus automated systems.
Generating Adversarial Driving Scenarios in High-Fidelity Simulators

In recent years self-driving vehicles have become more commonplace on public roads, with the promise of bringing safety and efficiency to modern transportation systems. Increasing the reliability of these vehicles on the road requires an extensive suite of software tests, ideally performed on highfidelity, photorealistic simulators, where multiple vehicles and pedestrians interact with the self-driving vehicle. It is therefore of critical importance to ensure that self-driving software is assessed against a wide range of challenging simulated driving scenarios. The state of the art in driving scenario generation, as adopted by the frontrunners of the self-driving car industry, still relies on human input [1]. In this paper we propose to automate the process using Bayesian Optimization to generate adversarial self-driving scenarios that expose poorly-engineered or poorly-trained self-driving policies, and increase the risk of collision with simulated pedestrians and vehicles. We show that by incorporating the generated scenarios into the training set of the self-driving policy, and by fine-tuning the policy using vision-based imitation learning we obtain safer self-driving behavior.
You Don't Know Jack About Software Maintenance

Long considered an afterthought, software maintenance is easiest and most effective when built into a system from the ground up.
Firms and the Coordination of KnowledgeSome Austrian Insights

This paper argues that Austrian economics allow us to identify a number of weak spots in the modern economics of organization. Thus, neither the dispersion of tacit and subjectively knowledge in organizations, nor the entrepreneurial discovery process are comprehensively treated in this body of thought. Thinking about these issues in the context of the firm leads to a different, but perhaps complementary perspective on economic organization.
A Category-Based Equational Logic Semantics to Constraint Programming

This paper exploits the point of view of constraint programming as computation in a logical system, namely constraint logic. We de ne the basic ingredients of constraint logic, such as constraint models and generalised polynomials. We show that constraint logic is an institution, and we internalise the study of constraint logic to the framework of category-based equational logic. By showing that constraint logic is a special case of category-based equational logic, we integrate the constraint logic programming paradigm into equational logic programming. Results include a Herbrand theorem for constraint logic programming characterising Herbrand models as initial models in constraint logic.
The Lesser Antilles and Aves Ridge

The island-arc complex of the Lesser Antilles (Fig. 1) borders the eastern margin of the Caribbean plate where the latter meets and is underthrust by the western Atlantic Ocean floor. The continuity of the topographic features, the seismicity, and the gravity anomalies from the Greater Antilles through the Lesser Antilles and into northern Venezuela establishes the existence of an active tectonic belt through these areas. The main physiographic feature of the Lesser Antilles is the crustal upwarp which is a relatively narrow ridge from Grenada to Guadeloupe but from there northward becomes a nearly flat-topped platform. Islands along the eastern margin of this platform are composed of Eocene to Oligocene volcanics and minor intrusives capped extensively by Miocene limestones, while the western margin is bordered by a chain of younger, Plio-Pleistocene volcanoes.
Unilateral pedicle screw fixation through a tubular retractor via the Wiltse approach compared with conventional bilateral pedicle screw fixation for single-segment degenerative lumbar instability: a prospective randomized study.

OBJECT
Treatment of patients with single-segment degenerative lumbar instability using unilateral pedicle screw fixation can achieve stability and fusion rates similar to those of bilateral pedicle screw fixation. The aim of this study was to analyze the clinical outcome of using unilateral pedicle screw fixation through a tubular retractor via the Wiltse approach to treat single-segment degenerative lumbar instability.


METHODS
Thirty-nine consecutive patients with single-segment, low-grade, degenerative lumbar instability were randomly assigned to treatment with either unilateral (n = 20) or bilateral (n = 19) pedicle screw fixation. In the unilateral group, patients underwent unilateral posterior lumbar interbody fusion (PLIF) and ipsilateral pedicle screw fixation through a tubular retractor via the Wiltse approach. In the bilateral group, patients underwent modified bilateral PLIF with bilateral pedicle screw fixation via the posterior midline approach. During follow-up, patients were evaluated using a visual analog scale (VAS), the Japanese Orthopaedic Association (JOA) score, and the Oswestry Disability Index.


RESULTS
The unilateral group had a shorter operative duration (p < 0.05) and less blood loss (p < 0.001). All patients completed more than 2 years of follow-up (mean 36 months). In general, the time trends in improvement on the VAS and JOA differed slightly between the groups through 2 years, but no significant difference in back pain VAS score or leg pain VAS score was found between these 2 groups at the 2-year follow-up. Complete bone fusion was shown on CT in all patients at the 2-year follow-up.


CONCLUSIONS
Unilateral pedicle screw fixation through a tubular retractor via the Wiltse approach appears to be as safe and effective as bilateral pedicle screw fixation for the treatment of single-segment degenerative lumbar instability.
Importance of evaluating conduction block in radiofrequency ablation for atrial fibrillation.

OBJECTIVE
Atrial fibrillation (AF) is the most frequently diagnosed cardiac arrhythmia. Anti-arrhythmic drugs may be used to suppress ectopic foci and interrupt reentry circuits, but are often insufficient to treat recurrent AF and have a number of adverse effects. Alternative therapies, such as catheter and surgical ablation, have been explored. This investigation examines the importance of assessing exit block when performing surgical ablation during beating-heart treatment of AF.


METHODS
This was an evaluation of pooled data from multicenter prospective results obtained in AF patients who received ablation with a new, irrigated, vacuum-integrated device that creates linear lesions during beating-heart/open-chest or minimally invasive, port-access procedures. Electrocardiogram or Holter data were collected intra-operatively and at 1, 3, 6, and 12 months. Outcomes were also evaluated for patients who were or 'were not' tested for exit block following the ablation procedure.


RESULTS
A total of 93 patients were treated (61 open-chest surgeries, 32 port-access procedures). There were no device-related complications and no operative mortality. At 341 days' average follow-up, 71/86 (83%) patients were free from AF, 66/86 (77%) were in sinus rhythm, and 60/86 (70%) were free from AF and off Class I and III anti-arrhythmic drugs (AADs). At 12 months, 23/23 (100%) patients with exit block confirmed were AF free compared with 13/21 (62%) patients with exit block not tested (p≤0.01, Fisher's exact test); 20/23 (87%) were in sinus rhythm compared with 12/21 (57%) patients with exit block not tested (p≤0.05, Fisher's exact test); and 20/23 (87%) were AF free without Class I and III AADs compared with 10/21 (48%) patients with exit block not tested (p≤0.01, Fisher's exact test). Both open-chest and port-access procedures yielded decreases in left-atrial size from baseline to 6 months' follow-up. Patients undergoing port-access procedures also observed an increase in left-ventricular ejection fraction, which was also significant at 6 months.


CONCLUSION
Patients in whom exit block was confirmed following an ablation procedure were more likely to have successful clinical outcomes. Since testing for exit block must be performed on a beating heart, total epicardial beating-heart ablation may provide an important treatment for AF, providing intra-operative feedback indicative of long-term outcomes.