LLukas22/scidocs huggingface dataset:
Some new findings on automatic generation control of an interconnected hydrothermal system with conventional controllers

This paper deals with automatic generation control of an interconnected hydrothermal system in continuous-discrete mode using conventional integral and proportional-integral controllers. Appropriate generation rate constraint has been considered for the thermal and hydro plants. The hydro area is considered with either mechanical or electric governor and thermal area is considered with either single or double reheat turbine. Performances of mechanical governor, electric governor, and single stage reheat turbine and two stage reheat turbine on dynamic responses have been explored. Further, selection of suitable value of speed regulation parameter R and sampling period has been investigated. System performance is examined considering 1% step load perturbation in either thermal or hydro area.
DRY CUPPING IN CHILDREN WITH FUNCTIONAL CONSTIPATION: A RANDOMIZED OPEN LABEL CLINICAL TRIAL

BACKGROUND
As a common disease in pediatrics, constipation poses a high burden to the community. In this study, we aimed to investigate the efficacy of dry cupping therapy (an Eastern traditional manipulative therapy) in children with functional constipation.


MATERIALS AND METHODS
One hundred and twenty children (4-18 years old) diagnosed as functional constipation according to ROME III criteria were assigned to receive a traditional dry cupping protocol on the abdominal wall for 8 minutes every other day or standard laxative therapy (Polyethylene glycol (PEG) 40% solution without electrolyte), 0.4 g/kg once daily) for 4 weeks, in an open label randomized controlled clinical trial using a parallel design with a 1:1 allocation ratio. Patients were evaluated prior to and following 2, 4, 8 and 12 weeks of the intervention commencement in terms of the ROME III criteria for functional constipation.


RESULTS
There were no significant differences between the two arms regarding demographic and clinical basic characteristics. After two weeks of the intervention, there was a significant better result in most of the items of ROME III criteria of patients in PEG group. In contrast, after four weeks of the intervention, the result was significantly better in the cupping group. There was no significant difference in the number of patients with constipation after 4 and 8 weeks of the follow-up period.


CONCLUSION
This study showed that dry cupping of the abdominal wall, as a traditional manipulative therapy, can be as effective as standard laxative therapy in children with functional constipation.
Foreword to the Special Section on Fungal Genomics

IN the new millennium, the challenge is to use sequenced genomes to predict how living systems evolve and function. The fungi as simple eukaryotes display emergent properties like development, aging, mating, pathogenicity, transvection, and gene silencing. Yet as microbial systems they provide
The Application on Intrusion Detection Based on K-means Cluster Algorithm

Internet security has been one of the most important problems in the world. Anomaly detection is the basic method to defend new attack in Intrusion Detection. Network intrusion detection is the process of monitoring the events occurring in a computing system or network and analyzing them for signs of intrusions, defined as attempts to compromise the confidentiality. A wide variety of data mining techniques have been applied to intrusion detections. In data mining, clustering is the most important unsupervised learning process used to find the structures or patterns in a collection of unlabeled data. We use the K-means algorithm to cluster and analyze the data in this paper. Computer simulations show that this method can detect unknown intrusions efficiently in the real network connections.
Nonradiating anapole modes in dielectric nanoparticles

Nonradiating current configurations attract attention of physicists for many years as possible models of stable atoms. One intriguing example of such a nonradiating source is known as 'anapole'. An anapole mode can be viewed as a composition of electric and toroidal dipole moments, resulting in destructive interference of the radiation fields due to similarity of their far-field scattering patterns. Here we demonstrate experimentally that dielectric nanoparticles can exhibit a radiationless anapole mode in visible. We achieve the spectral overlap of the toroidal and electric dipole modes through a geometry tuning, and observe a highly pronounced dip in the far-field scattering accompanied by the specific near-field distribution associated with the anapole mode. The anapole physics provides a unique playground for the study of electromagnetic properties of nontrivial excitations of complex fields, reciprocity violation and Aharonov-Bohm like phenomena at optical frequencies.
A PRIMER TO RELATIVISTIC MOND THEORY

We first review the nonrelativistic lagrangian theory as a framework for the MOND equation. Obstructions to a relativistic version of it are discussed leading up to TeVeS, a relativistic tensor-vectorscalar field theory which displays both MOND and Newtonian limits. The whys for its particular structure are discussed and its achievements so far are summarized.
A randomized, double-blind, placebo-controlled clinical trial of the effectiveness of the novel serotonin type 3 receptor antagonist ramosetron in both male and female Japanese patients with diarrhea-predominant irritable bowel syndrome.

OBJECTIVE
Irritable bowel syndrome is characterized by abdominal discomfort and/or pain associated with altered bowel habits. The neurotransmitter serotonin and serotonin type 3 receptors that are extensively distributed on enteric neurons in the human gastrointestinal tract play a role in increasing the sensation of pain and affecting bowel habits in patients with irritable bowel syndrome. The aim of this study was to evaluate the efficacy and safety of the serotonin type 3 receptor antagonist ramosetron hydrochloride in Japanese patients with diarrhea-predominant irritable bowel syndrome.


MATERIAL AND METHODS
In a double-blind, placebo-controlled, parallel group-comparative study with a 1-week run-in period, 539 patients with diarrhea-predominant irritable bowel syndrome meeting the Rome II diagnostic criteria received either 5 microg ramosetron hydrochloride (n=270) or placebo (n=269) once daily for 12 weeks.


RESULTS
Forty-seven percent of ramosetron hydrochloride-treated patients were monthly responders in the primary end-point, "Patient-reported global assessment of relief of irritable bowel syndrome symptoms", compared with 27% for placebos (p<0.001). The most frequently reported adverse event in the ramosetron hydrochloride-treated group compared with the placebo group was hard stool.


CONCLUSIONS
Ramosetron hydrochloride 5 microg once daily is effective and well tolerated in the treatment of abdominal pain, discomfort and bowel habits in patients with diarrhea-predominant irritable bowel syndrome.
Implementation of Total Quality Management and Its Effect on Organizational Performance of Manufacturing Industries Through Organizational Culture in South Sulawesi, Indonesia

This study aims to examine the application of Total Quality Management (TQM) in a variety of manufacturing companies located in the Industrial Area Makassar in South Sulawesi, Indonesia to see its effect on organizational performance, both directly and indirectly through the mediating variable of organizational culture of the company. Hypothesized that TQM affect organizational performance directly and indirectly through the mediating variable of organizational culture. This hypothesis was derived from nine sub-hypotheses that are constructed in Structural Equation Model and verified by using path analysis. Results from this early stage of confirmatory research revealed that there is no significant direct influence of TQM implementation in various manufacturing companies. However, TQM significantly affect organizational performance via a mediating variable of organizational culture. Thus, current research unearth four interesting findings, in which three of them point to the significance of TQM implementation on organizational culture, organizational culture on organizational performance, and TQM implementation on organizational performance through organizational culture. Finally it was found out that TQM implementation is not directly significant to organizational performance.
Supporting ITIL processes implementation using business process management systems

ITIL is one of the most used frameworks for IT service management. Implementing ITIL processes through an organization is not an easy task and present many difficulties. This paper explores the ITIL implementation's challenges and tries to experiment how Business Process Management Systems can help organization overtake those challenges.
A new framework for business impact analysis in business continuity management ( with a case study

Resumption of critical processes/functions after occurrence of any disruptive event is essential from the business continuity (BC) viewpoint. Business impact analysis (BIA) is a key part of a business continuity management system (BCMS) in which an organization’s key products/services along with the critical functions and their BC related indices, i.e., the maximum tolerable period of disruption (MTPD) and the minimum business continuity objective (MBCO) are determined. This study proposes a novel framework to conduct the BIA in organizations in a more systematic and comprehensive way mostly by relying on some effective multi attribute decision making (MADM) techniques. A case study in an auto part manufacturer is also provided to validate the proposed framework whose results demonstrate the applicability and usefulness of the proposed approach. 2014 Elsevier Ltd. All rights reserved.
Home enteral nutrition in children: a 14-year multicenter survey

Background/Objectives:The practice of home enteral nutrition (HEN) represents a relevant aspect of the clinical management of both malnourished children and well-nourished children unable to be fed using an oral diet. The aim of this study was to estimate in an Italian paediatric population over a 14-year period (1996–2009), the clinical relevance and results over time of HEN activity.Subjects/methods:HEN-computerized database and medical/dietetic charts were evaluated for patients aged at start of HEN <18 years and HEN duration >1 month.Results:During the study period, we recorded 757 HEN programs. HEN began at a median age of 2 years for a median duration of 8.1 months. The complication rate was 14.8%. In the second period of the survey (2003–2009), the main changes concerned the underlying diseases requiring HEN, choice of formula feeding and access route. In 2009, the estimated overall prevalence of HEN was 3.47 and the incidence 2.45 per 100 000 inhabitants from 0 to 18 years of age.Conclusions:The epidemiological data of this study demonstrate that HEN concerns a growing number of Italian children and families. Some aspects of HEN clinical management should be modified to reach the recommended standards.
Combinatorial Attacks on Binarized Neural Networks

q Adversarial Attack: a small perturbation to an input that fools ML model into predicting incorrect output (STOP→YIELD) q Attack-to-Protect: designing better algorithms for generating adversarial perturbations helps train robust ML models q ML model ⎯ Binarized Neural Network (BNN): • Weights: +1 / -1 • Activation: sign & ∈ {−1,+1} q Why care about BNNs? • Fast inference / Small size • Great for low-power devices, smartphones
Effects of topiramate or naltrexone on tobacco use among male alcohol-dependent outpatients.

BACKGROUND
A high smoking prevalence has been registered among alcoholics. It has been pointed out that alcoholic smokers may have a more severe course and greater severity of alcoholism. This study aims at comparing smoking and non-smoking alcoholics in terms of treatment outcomes and verifying the efficacy of topiramate and naltrexone to decrease the use of cigarettes among alcoholic smokers.


METHODS
The investigation was a double-blind, placebo-controlled, 12-week study carried out at the University of São Paulo, Brazil. The sample comprised 155 male alcohol-dependent outpatients (52 non-smokers and 103 smokers), 18-60 years of age, with an International Classification of Diseases (ICD-10) diagnosis of alcohol dependence. After a 1-week detoxification period, the patients randomly received placebo, naltrexone (50mg/day) or topiramate (up to 300 mg/day). Only the alcoholic smokers who adhered to the treatment were evaluated with reference to the smoking reduction.


RESULTS
Cox regression analysis revealed that the smoking status among alcoholics increased the odds of relapse into drinking by 65%, independently of the medications prescribed, using the intention-to-treat method. Topiramate showed effectiveness to reduce the number of cigarettes smoked when compared to placebo among adherent patients (mean difference=7.91, p<0.01). There were no significant differences between the naltrexone group and the placebo group.


CONCLUSIONS
The results of this study confirm that the treatment is more challenging for smoking alcoholics than for non-smoking ones and support the efficacy of topiramate in the smoking reduction among male alcoholic smokers who adhered to the treatment.
Model Predictive Approach for a Simple and Effective Load Voltage Control of Four-Leg Inverter With an Output  $LC$ Filter

This paper presents a finite control set model predictive strategy and its application to the load voltage control of two-level four-leg inverters. The proposed approach uses the novel discrete-time model of the inverter and output LC filter in order to predict the variables to be controlled. These predictions are carried out for the 16 switching states of the inverter and are evaluated using a cost function. The switching state that forces the load voltages to be closest to their respective references is chosen and applied to the inverter. The behavior of the predictive controller has been investigated, and the changes to both inductive and capacitive filter parameters have been considered. In order to improve the reliability of the fourth leg as well as the overall inverter efficiency, a solution is proposed, which combines hardware and software reconfigurations. The feasibility of the proposed method is verified through simulation and experimental results considering single-/three-phase, balanced/unbalanced, and linear/nonlinear loads.
The effect of venlafaxine compared with other antidepressants and placebo in the treatment of major depression

Meta-analysis of all available trials of Venlafaxine in the treatment of major depressive disorders, including treatment resistant depression and long-term relapse prevention. We conducted a meta-analysis comparing venlafaxine and tricyclics, or selective serotonin reuptake inhibitors (SSRIs), in major depression. We also included trials comparing venlafaxine and alternative antidepressants in subjects with treatment resistant depression, or compared with placebo in long-term relapse prevention. Trials were identified through searches of Medline, Embase, Cochrane Library and through accessing unpublished trials held by the manufacturer. Results based on intention to treat analyses where available, were pooled using theoretically exact conditional maximum likelihood methods for fixed effects (primary analyses), and numerical simulation using a Gibbs sampler for full random effects. Compared to all SSRIs for the treatment of major depression (fluoxetine, paroxetine, sertraline, citalopram, escitalopram and fluvoxamine), venlafaxine was associated with a greater response [odds ratio 1.15 (95% CI 1.02–1.29)] and remission [odds ratio 1.19 (95% CI 1.06–1.34)]. Overall drop out rates appeared similar for SSRIs and venlafaxine. Compared to tricyclics, response to venlafaxine was estimated to be greater by exact method, odds ratio 1.21 (95% CI 1.03–1.43), but not statistically significantly different, using a full random effects method odds ratio 1.22 (95% CI 0.96–1.54). We observed no difference in remission rates (odds ratio 1.06 (95% CI 0.74–1.63)). Tricyclics were less well tolerated with higher overall drop out rates. Compared to alternative antidepressants in treatment resistant depression (trials included comparison with sertraline, bupropion, fluoxetine, citalopram, and one with a range of agents—mostly SSRIs), the odds ratio for response was 1.35 (95% CI 1.19–1.54). The odds ratio for remission was 1.35 (95% CI 1.20–1.52). Compared to placebo the odds ratio for relapse prevention with venlafaxine was 0.37 (95% CI 0.27–0.51). This meta analysis provides evidence of the clinical efficacy of venlafaxine in achieving therapeutic response and remission in patients with major depression. Venlafaxine appears more effective than SSRIs, and at least as effective as tricyclic antidepressants, in the treatment of major depressive episode. Venlafaxine appeared more effective than comparators in treatment resistant depression. In addition, venlafaxine effective in reducing relapse when given long term after major depressive episode.
Knowledge and attitude of European urology residents about ionizing radiation.

OBJECTIVE
To evaluate the attitude and knowledge of urology residents concerning ionizing radiation, we undertook a survey of European urology residents.


METHODS
The questionnaire was sent to 1184 urology residents within the database of the European Society of Residents in Urology (ESRU) by e-mail between November 2011 and January 2012. The questionnaire was composed of demographic questions and questions about the frequency of radiation exposure and use of radiation safety measures during fluoroscopy-guided endourologic procedures. In addition, there were questions about education programs and respondents' knowledge about diagnostic imaging modalities.


RESULTS
A total of 124 questionnaires were returned from urology residents in 20 different European countries. All of the respondents reported that they were routinely exposed to ionizing radiation, and 69 (72.5%) were exposed more than 3 times per week. Despite the common but not sufficient use of lead aprons (75%), use of other radiation protection measures was very low. Although 55% of the respondents had attended an education program in Europe about radiation safety, attendance was highest in Poland (82.6%). The level of knowledge about ionizing radiation was low among urology residents, and approximately half of responders had no idea that commonly used imaging modalities have a fatal cancer risk.


CONCLUSION
The results of this study showed the lack of knowledge and awareness about the importance of ionizing radiation protection among urology residents in Europe. We therefore suggest radiation safety courses in every step of medical life for doctors, especially for endourologists.
Quality of life is more impaired in patients seeking medical care for food allergy.

BACKGROUND
Food allergy (FA) affects 2-4% of adults, but only a small percentage visit an outpatient clinic for a thorough evaluation.


METHODS
A matched case-control study was used to compare health-related quality of life (HRQL) of the Dutch general population that did not seek medical care for their FA with outpatients who did seek medical care. All participants were diagnosed as food allergic (i.e. with a suggestive history and corresponding positive IgE). HRQL was measured using the Food Allergy Quality of Life Questionnaire--Adult Form (FAQLQ-AF). A food allergy independent measure (FAIM) was used to evaluate the adult's perception of the severity of his/her disease.


RESULTS
Total FAQLQ-AF score in individuals who never visited a doctor for their FA was significantly lower than that of patients who sought medical care (2.4 vs. 3.9, p = 0.03), indicating that the former had a better quality of life than patients who did seek medical care. Regarding the different domains of FAQLQ, the score for allergen avoidance and dietary restrictions and the score for emotional impact (EI) was significantly higher in the group that sought medical care (p = 0.02 and 0.03, respectively), indicating the importance of these domains. The FAIM score was significantly higher in the group that sought medical care, indicating that they perceived their FA as more severe.


CONCLUSION AND CLINICAL RELEVANCE
Patients who seek medical care for their FA have a more impaired HRQL and perceive their FA as more severe. Food avoidance and issues related to the EI of FA are key areas of intervention aimed at improving HRQL in patients with FA.
Production of O/W Emulsions Containing Astaxanthin by Repeated Premix Membrane Emulsification

Oil-in-Water (O/W) emulsions are mainly produced by application of high mechanical stress or by membrane emulsification processes at low pressures. Advantages such as narrower droplet size distribution and lower operating costs make membrane emulsification processes more suitable for producing astaxanthin-loaded O/W emulsions. The characteristics of 1 of these membrane emulsification methods, called repeated premix membrane emulsification, are studied in this work. In this emulsification process, a pre-emulsion is repeatedly pushed through a hydrophilic or hydrophobic membrane. In this research, a hydrophilic membrane was used because the objective was to obtain an O/W emulsion. Pre-emulsions were produced by dispersing palm oil containing dissolved astaxanthin in water. The oil droplets were stabilized with a combination of 2 emulsifiers. Each O/W emulsion passed the membrane 3 times under pressures and disperse phase fractions of 5 to 15 bar and from 10 wt% to 40 wt%, respectively. To investigate the production of O/W emulsions by repeated premix membrane emulsification, mean Sauter diameters and fluxes were measured. To find the optimal ranges of pressure and dispersed phase fraction, a “2-level factorial design with central composite and stars points” experimental design was applied.
Amelioration of small bowel injury by switching from nonselective nonsteroidal anti-inflammatory drugs to celecoxib in rheumatoid arthritis patients: a pilot study.

BACKGROUND/AIMS
Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used in patients with rheumatoid arthritis (RA) but have several side effects including mucosal damage in the small intestine. We aimed to evaluate whether the small bowel injury is ameliorated by switching from nonselective NSAIDs to celecoxib in patients with RA.


METHODS
Sixteen patients with RA who were treated with nonselective NSAIDs were enrolled in this study. Nonselective NSAIDs were converted to celecoxib for 12 weeks. Capsule endoscopy was performed before and after treatment with celecoxib. Videos were screened by gastroenterologists blinded to the patients' treatment.


RESULTS
Before the administration of celecoxib, reddened folds, denuded areas, petechiae/red spots and mucosal breaks were observed in 63, 63, 88 and 69% of the patients, respectively. In the 14 patients who completed this study, conversion to celecoxib significantly reduced the number of petechiae/red spots, the number of mucosal breaks, and Lewis scores. RA activity and cytokine levels in the peripheral blood were not significantly different before and after treatment with celecoxib.


CONCLUSIONS
The incidence of small bowel injury by nonselective NSAIDs is high in patients with RA. Conversion from nonselective NSAIDs to celecoxib can be useful for protecting patients with RA from small bowel injury.