LLukas22/scidocs huggingface dataset:
Miniaturized electroencephalographic scalp electrode for optimal wearing comfort

OBJECTIVE
Current mainstream EEG electrode setups permit efficient recordings, but are often bulky and uncomfortable for subjects. Here we introduce a novel type of EEG electrode, which is designed for an optimal wearing comfort. The electrode is referred to as C-electrode where "C" stands for comfort.


METHODS
The C-electrode does not require any holder/cap for fixation on the head nor does it use traditional pads/lining of disposable electrodes - thus, it does not disturb subjects. Fixation of the C-electrode on the scalp is based entirely on the adhesive interaction between the very light C-electrode/wire construction (<35 mg) and a droplet of EEG paste/gel. Moreover, because of its miniaturization, both C-electrode (diameter 2-3mm) and a wire (diameter approximately 50 microm) are minimally (or not at all) visible to an external observer. EEG recordings with standard and C-electrodes were performed during rest condition, self-paced movements and median nerve stimulation.


RESULTS
The quality of EEG recordings for all three types of experimental conditions was similar for standard and C-electrodes, i.e., for near-DC recordings (Bereitschaftspotential), standard rest EEG spectra (1-45 Hz) and very fast oscillations approximately 600 Hz (somatosensory evoked potentials). The tests showed also that once being placed on a subject's head, C-electrodes can be used for 9h without any loss in EEG recording quality. Furthermore, we showed that C-electrodes can be effectively utilized for Brain-Computer Interfacing. C-electrodes proved to posses a high stability of mechanical fixation (stayed attached with 2.5 g accelerations). Subjects also reported not having any tactile sensations associated with wearing of C-electrodes.


CONCLUSION
C-electrodes provide optimal wearing comfort without any loss in the quality of EEG recordings.


SIGNIFICANCE
We anticipate that C-electrodes can be used in a wide range of clinical, research and emerging neuro-technological environments.
Energy-efficiency bounds for deep submicron VLSI systems in the presence of noise

In this paper, we present an algorithm for computing the bounds on energy-efficiency of digital very large scale integration (VLSI) systems in the presence of deep submicron noise. The proposed algorithm is based on asoft-decision channel model of noisy VLSI systems and employs information–theoretic arguments. Bounds on energy-efficiency are computed for multimodule systems, static gates, dynamic circuits and noise-tolerant dynamic circuits in 0.25m CMOS technology. As the complexity of the proposed algorithm grows linearly with the size of the system, it is suitable for computing the bounds on energy-efficiency for complex VLSI systems. A key result presented is that noise-tolerant dynamic circuits offer the best trade off between energy-efficiency and noise-immunity when compared to static and domino circuits. Furthermore, employing a 16-bit noise-tolerant Manchester adder in a CDMA receiver, we demonstrate a 31.2%–51.4% energy reduction over conventional systems when operating in the presence of noise. In addition, we compute the lower bounds on energy dissipation for this CDMA receiver and show that these lower bounds are 2.8 below the actual energy consumed, and that noise-tolerance reduces the gap between the lower bounds and actual energy dissipation by a factor of 1.9 .
Relating microbial community structure to functioning in forest soil organic carbon transformation and turnover

Forest soils store vast amounts of terrestrial carbon, but we are still limited in mechanistic understanding on how soil organic carbon (SOC) stabilization or turnover is controlled by biotic and abiotic factors in forest ecosystems. We used phospholipid fatty acids (PLFAs) as biomarker to study soil microbial community structure and measured activities of five extracellular enzymes involved in the degradation of cellulose (i.e., β-1,4-glucosidase and cellobiohydrolase), chitin (i.e., β-1,4-N-acetylglucosaminidase), and lignin (i.e., phenol oxidase and peroxidase) as indicators of soil microbial functioning in carbon transformation or turnover across varying biotic and abiotic conditions in a typical temperate forest ecosystem in central China. Redundancy analysis (RDA) was performed to determine the interrelationship between individual PFLAs and biotic and abiotic site factors as well as the linkage between soil microbial structure and function. Path analysis was further conducted to examine the controls of site factors on soil microbial community structure and the regulatory pathway of changes in SOC relating to microbial community structure and function. We found that soil microbial community structure is strongly influenced by water, temperature, SOC, fine root mass, clay content, and C/N ratio in soils and that the relative abundance of Gram-negative bacteria, saprophytic fungi, and actinomycetes explained most of the variations in the specific activities of soil enzymes involved in SOC transformation or turnover. The abundance of soil bacterial communities is strongly linked with the extracellular enzymes involved in carbon transformation, whereas the abundance of saprophytic fungi is associated with activities of extracellular enzymes driving carbon oxidation. Findings in this study demonstrate the complex interactions and linkage among plant traits, microenvironment, and soil physiochemical properties in affecting SOC via microbial regulations.
Low-dose terlipressin plus banding ligation versus low-dose terlipressin alone in the prevention of very early rebleeding of oesophageal varices.

BACKGROUND
Very early rebleeding is frequently encountered in patients with acute oesophageal variceal bleeding. A trial was designed to assess the efficacy and safety in patients with no active bleeding at endoscopy, receiving banding ligation association with terlipressin to prevent very early rebleeding.


METHODS
Patients with no active variceal bleeding at endoscopy were evaluated. Eligible patients were randomised to receive terlipressin infusion alone for 5 days (Terlipressin group) or banding ligation plus terlipressin infusion for 2 days (Combined group). Primary endpoints were treatment failure and very early rebleeding.


RESULTS
The terlipressin group was composed of 46 patients and the Combined group was composed of 47 patients. Both groups were comparable in terms of baseline data. Forty-eight-hour haemostasis was achieved in 91% in the Terlipressin group and 98% in the Combined group (p = 0.20). Very early rebleeding within 48-120 h occurred in 7 patients (15%) in the Terlipressin group but not in any patients (0%) in the Combined group (p = 0.006). Treatment failure was 24% in the Terlipressin group and 2% in the Combined group (p = 0.002). Multivariate analysis revealed that treatment (OR 0.081; 95% CI 0.010 to 0.627) was the only predictive factor of very early rebleeding. Blood requirement was significantly lower in the Combined group than in the Terlipressin group. Complications and 6-week survival were similar in both groups.


CONCLUSIONS
Combination of banding ligation and terlipressin infusion for 2 days was superior to only infusion of terlipressin for 5 days in the reduction of very early rebleeding and treatment failure in patients with inactive variceal bleeding at endoscopy.


TRIAL REGISTRATION NUMBER
ISRCTN28353453.
Rethinking individual and community fall prevention strategies: a meta-regression comparing single and multifactorial interventions.

BACKGROUND
Guidelines recommend that fall prevention programmes for older people include multifactorial interventions.


OBJECTIVE
We aimed to determine if randomised controlled trial evidence supports interventions with multiple components over single strategies in community based fall prevention.


METHODS
We searched the literature for trials of interventions aimed at preventing falls. We included trials if they met the following criteria: (i) participants were randomly allocated to intervention and control groups, (ii) all participants were aged 65 years or older, (iii) the majority lived independently in the community, (iv) fall events were recorded prospectively using a diary or calendar during the entire trial and monitored at least monthly, (v) follow up was for 12 months or longer, (vi) at least 70% of participants completed the trial, (vii) all falls during the trial for at least 50 participants were included in the analysis, and (viii) a relative rate ratio with 95% CI comparing the number of falls in the intervention and control groups was reported. We calculated a pooled rate ratio separately for trials testing multifactorial and single interventions and compared their overall efficacy using meta-regression.


RESULTS
Meta-regression showed that single interventions were as effective in reducing falls as interventions with multiple components (pooled rate ratios 0.77, 95% CI 0.67-0.89 and 0.78, 0.68-0.89 respectively).


CONCLUSION
Multifactorial fall prevention interventions are effective for individual patients. However, for community programmes for populations at risk, targeted single interventions are as effective as multifactorial interventions, may be more acceptable and cost effective.
Time trends in primary resistance to HIV drugs in the United Kingdom: multicentre observational study.

OBJECTIVE
To examine whether the level of primary resistance to HIV drugs is increasing in the United Kingdom.


DESIGN
Multicentre observational study.


SETTING
All virology laboratories in the United Kingdom carrying out tests for HIV resistance as part of routine clinical care.


PARTICIPANTS
2357 people infected with HIV who were tested for resistance before receiving antiretroviral therapy.


MAIN OUTCOME MEASURE
Prevalence of drug resistance on basis of the Stanford genotypic interpretation system.


RESULTS
Over the study period (February 1996 to May 2003), 335 (14.2%, 95% confidence interval 12.8% to 15.7%) samples had mutations that conferred resistance to one or more antiretroviral drugs (9.3% high level resistance, 5.9% medium level resistance). The prevalence of primary resistance has increased markedly over time, although patterns are specific to drug class; the largest increase was for non-nucleoside reverse transcriptase inhibitors. In 2002-3, the prevalence of resistance to any antiretroviral drug to nucleoside or nucleotide reverse transcriptase inhibitors, to non-nucleoside reverse transcriptase inhibitors, or to protease inhibitors was 19.2% (15.7% to 23.2%), 12.4% (9.5% to 15.9%), 8.1% (5.8% to 11.1%), and 6.6% (4.4% to 9.3%), respectively. The risk of primary resistance was only weakly related to most demographic and clinical factors, including ethnicity and viral subtype.


CONCLUSIONS
The United Kingdom has one of the highest reported rates of primary resistance to HIV drugs worldwide. Prevalence seems still to be increasing and is high in all demographic subgroups.
Numerical and experimental investigation of the strength of corrugated board packages

Goods that are shipped world-wide travel protected by packages that are frequently made of corrugated board. Therefore, the strength of corrugated board containers is crucial for preserving the content, while an optimization of corrugated board containers is essential to save money and resources. Unfortunately, standard compression tests show a wide dispersion in container performance, and so, to avoid failure often containers have to be overdesigned. Dispersion in performance arises from different factors, among which the most important are variable quality of raw materials, imperfections produced by the manufacturing process in local and global geometry, and environmental conditions. Standard quality tests performed on the finished container are affected simultaneously by influencing parameters making identification of the cause of the lack of strength a difficult task. Structural analysis of paperboard components is a critical topic in the design of containers that have to withstand compression loads due to stacking. The evaluation of a container’s buckling behaviour requires a deep knowledge of paperboard stiffness properties. In the reviewed literature we found studies on the strength of paperboard, including the effect of local buckling exhibited by the liners. However, in this study elastic properties are evaluated using composite laminate plate theory. A numerical procedure was proposed to evaluate the global and local instability of paperboard sheets loaded in both the machine and the cross-direction, taking into account the actual microstructure, with a simplified tooth-shaped geometric model. PACKAGING TECHNOLOGY AND SCIENCE Packag. Technol. Sci. 2003; 16: 47–60 DOI:10.1002/pts.609
A Review of Fixed Bed Gasification Systems for Biomass

The gasification of biomass into useful fuel enhances its potential as a renewable energy resource. The fixed bed gasification systems are classified as updraft, Imbert downdraft, throatless downdraft, crossdraft and two stage gasifiers. Updraft gasifiers are suitable for gasification of biomass containing high ash (up to 15 %) and high moisture content (up to 50 %) and generate producer gas having high tar content (50–100 g/Nm). The high temperature (830 C) air gasification of biomass in updraft gasifiers increase the lower calorific value of producer gas and reduce the tar content. The updraft gasifiers have been used for gasification of bark, wood blocks, chips and pellets, straw, maize cobs, refuse derived fuel (RDF), and waste pellets with air and O2 as the gasifying media. The Imbert downdraft gasifiers are suitable to handle biomass fuel having ash and moisture content less than five per cent and 20% respectively. Modifications in the design of grate and hopper of Imbert downdraft gasifiers have been suggested to gasify non-woody biomass such as coir dust, cotton stalks, wheat straw, hazelnut shells, leather residues, sludge etc. Downdraft gasifiers yield producer gas with lower tar content (1-2 g/Nm) than updraft gasifiers. Throatless downdraft gasifiers have been developed to overcome the problems of bridging and channelling in Imbert downdraft gasifiers. The throatless gasifiers have been successfully used for gasification of rice husk, wood chips, bagasse, sugarcane leaves, coconut shells etc. Improving the insulation of the gasifier, re-circulation of producer gas and varying the air distribution have been reported to enhance the performance of the throatless gasifiers and reduce the tar content to 50–250 mg/Nm. In two stage gasifiers, pyrolysis and gasification of biomass takes place in separate chambers resulting in low tar (15–50 mg/Nm) producer gas. Some aspects of the research and development in fixed bed gasification of biomass and their commercial applications are reviewed and cited in this paper.
Erlotinib is effective in pancreatic cancer with epidermal growth factor receptor mutations: a randomized, open-label, prospective trial

OBJECTIVE
To analyze the efficacy of gemcitabine with or without erlotinib for pancreatic cancer, and to determine the predictive role of epidermal growth factor receptor (EGFR) and KRAS mutations in these patients.


METHODS
This was a single-center, randomized, open-label, prospective trial. Eighty-eight chemotherapy-naïve metastatic pancreatic cancer patients were randomized for treatment with gemcitabine or gemcitabine plus erlotinib. EGFR and KRAS mutations were analyzed, respectively. The primary endpoint was the disease control rate.


RESULTS
Disease control rate (64% vs. 25%; P < 0.001), progression-free survival (median 3.8 vs. 2.4 months; P < 0.001), and overall survival (median 7.2 vs. 4.4 months; P < 0.001) were better in the gemcitabine plus erlotinib group than in the gemcitabine alone group. In the gemcitabine plus erlotinib group, disease control (85% vs. 33%; P = 0.001), progression-free survival (median 5.9 vs. 2.4 months; P = 0.004), and overall survival (median 8.7 vs. 6.0 months; P = 0.044) were better in patients with EGFR mutations than in those without EGFR mutations. KRAS mutation was not associated with treatment response or survival.


CONCLUSIONS
Gemcitabine plus erlotinib is more effective than gemcitabine alone for treating metastatic pancreatic cancer patients, especially those with EGFR mutations. ClinicalTrials.gov number, NCT01608841.
Effect of mindfulness-based stress reduction on sleep quality: results of a randomized trial among Danish breast cancer patients.

UNLABELLED
The prevalence of sleep disturbance is high among cancer patients, and the sleep problems tend to last for years after the end of treatment. As part of a large randomized controlled clinical trial (the MICA trial, NCT00990977) of the effect of mindfulness-based stress reduction (MBSR) on psychological and somatic symptoms among breast cancer patients, the aim of the current study was to evaluate the effect of MBSR on the secondary outcome, 'sleep quality'.


MATERIAL AND METHODS
A total of 336 women operated on for breast cancer stage I-III 3-18 months previously were randomized to MBSR (n = 168) or treatment as usual (n = 168); both groups received standard clinical care. The intervention consisted of an eight-week MBSR program (psycho-education, meditation and gentle yoga). Sleep quality was assessed on the Medical Outcome Study sleep scale at baseline, after the intervention and at six- and 12-months' follow-up.


RESULTS
The mean sleep problem scores were significantly lower in the MBSR group than in controls immediately after the intervention. Quantile regression analyses showed that the effect was statistically significant only for the participants represented by the lower percentile of change between baseline and post-intervention, i.e. those who had more sleep problems; the MBSR group had a significantly smaller increase in sleep problems than the control group. After the 12-month follow-up, there was no significant between-group effect of MBSR on sleep quality in intention-to-treat analyses.


CONCLUSION
MBSR had a statistically significant effect on sleep quality just after the intervention but no long-term effect among breast cancer patients. Future trials in which participation is restricted to patients with significant sleep problems are recommended for evaluating the effect of MBSR on sleep quality.
Dermoscopy of pigmented skin lesions: results of a consensus meeting via the Internet.

BACKGROUND
There is a need for better standardization of the dermoscopic terminology in assessing pigmented skin lesions.


OBJECTIVE
The virtual Consensus Net Meeting on Dermoscopy was organized to investigate reproducibility and validity of the various features and diagnostic algorithms.


METHODS
Dermoscopic images of 108 lesions were evaluated via the Internet by 40 experienced dermoscopists using a 2-step diagnostic procedure. The first-step algorithm distinguished melanocytic versus nonmelanocytic lesions. The second step in the diagnostic procedure used 4 algorithms (pattern analysis, ABCD rule, Menzies method, and 7-point checklist) to distinguish melanoma versus benign melanocytic lesions. kappa Values, log odds ratios, sensitivity, specificity, and positive likelihood ratios were estimated for all diagnostic algorithms and dermoscopic features.


RESULTS
Interobserver agreement was fair to good for all diagnostic methods, but it was poor for the majority of dermoscopic criteria. Intraobserver agreement was good to excellent for all algorithms and features considered. Pattern analysis allowed the best diagnostic performance (positive likelihood ratio: 5.1), whereas alternative algorithms revealed comparable sensitivity but less specificity. Interobserver agreement on management decisions made by dermoscopy was fairly good (mean kappa value: 0.53).


CONCLUSION
The virtual Consensus Net Meeting on Dermoscopy represents a valid tool for better standardization of the dermoscopic terminology and, moreover, opens up a new territory for diagnosing and managing pigmented skin lesions.
Antifungal Leaf-Surface Metabolites Correlate with Fungal Abundance in Sagebrush Populations

A central component in understanding plant–enemy interactions is to determine whether plant enemies, such as herbivores and pathogens, mediate the evolution of plant secondary metabolites. Using 26 populations of a broadly distributed plant species, sagebrush (Artemisia tridentata), we examined whether sagebrush populations in habitats with a greater prevalence of fungi contained antifungal secondary metabolites on leaf surfaces that were more active and diverse than sagebrush populations in habitats less favorable to fungi. Because moisture and temperature play a key role in the epidemiology of most plant–pathogen interactions, we also examined the relationship between the antifungal activity of secondary metabolites and the climate of a site. We evaluated the antifungal activity of sagebrush secondary metabolites against two fungi, a wild Penicillium sp. and a laboratory yeast, Saccharomyces cerevisiae, using a filter-paper disk assay and bioautography. Comparing the 26 sagebrush populations, we found that fungal abundance was a good predictor of both the activity (r 2 = 0.36 for Saccharomyces, r 2 = 0.37 for Penicillium) and number (r 2 = 0.34 for Saccharomyces) of antifungal secondary metabolites. This suggests that selection imposed by fungal pathogens has led to more effective antifungal secondary metabolites. We found that the antifungal activity of sagebrush secondary metabolites was negatively related to average vapor pressure deficit of the habitat (r 2 = 0.60 for Saccharomyces, r 2 = 0.61 for Penicillium). Differences in antifungal activity among populations were not due to the amount of secondary metabolites, but rather to qualitative differences in the composition of antifungal compounds. Although all populations in habitats with high fungal prevalence had secondary metabolites with high antifungal activity, different suites of compounds were responsible for this activity, suggesting independent outcomes of selection on plants by fungal pathogens. The location of antifungal secondary metabolites on the leaf surface is consistent with their putative defense role, and we found no evidence supporting other functions, such as protection from ultraviolet light or oxidation. That the antifungal activity of sagebrush secondary metabolites was similar for two different fungi provides support for broad antifungal defenses. The incidence and severity of fungal disease in the field (caused by Puccinia tanaceti) were similar in moist and dry habitats, possibly reflecting an equilibrium between plant defense and fungal attack, as sites with greater fungal abundance compensated with more effective secondary metabolites. The geographic correlation between fungal abundance and antifungal secondary metabolites of sagebrush, coupled with our other data showing heritable variation in these metabolites, suggests that pathogenic fungi have selected for antifungal secondary metabolites in sagebrush.