LLukas22/scidocs huggingface dataset:
Surgical complications of skin sparing mastectomy and immediate prosthetic reconstruction after neoadjuvant chemotherapy for invasive breast cancer.

BACKGROUND
Neoadjuvant chemotherapy is gaining acceptance as an option for breast cancer treatment, particularly in young women. These women may seek immediate breast reconstruction after mastectomy even though it is not known whether such preoperative chemotherapy may be detrimental to post-reconstruction wound healing. Therefore, we set out to assess the influence of neoadjuvant chemotherapy for invasive breast cancer on the short-term complications after skin sparing mastectomy and immediate prosthetic reconstruction.


METHODOLOGY
The short-term surgical outcome of 48 immediate breast reconstructions in 37 women treated with neoadjuvant chemotherapy from 2006 through 2009 was prospectively compared to that of 215 immediate reconstructions in 176 women who were operated in the same period without neoadjuvant chemotherapy.


RESULTS
The overall rate of short-term postoperative complications was significantly less among neoadjuvantly treated women (15% vs. 29%; p = 0.042) but this did not result in a reduction of loss of prostheses (8% vs. 11%; p = 0.566).


CONCLUSION
Because neoadjuvant chemotherapy is not associated with an increase in short-term complications after skin sparing mastectomy and immediate prosthetic reconstruction in patients with invasive breast cancer, such combined surgical therapy may be offered as treatment option for this particular group of patients also.
How Do You Want Your Chatbot? An Exploratory Wizard-of-Oz Study with Young, Urban Indians

As text-messaging chatbots become increasingly “human”, it will be important to understand the personal interactions that users are seeking with a chatbot. What chatbot personalities are most compelling to young, urban users in India? To explore this question, we first conducted exploratory Wizard-of-Oz (WoZ) studies with 14 users that simulated interactions with a hypothetical chatbot. We evaluated three personalities for the chatbot—Maya, a productivity oriented bot with nerd wit; Ada, a fun, flirtatious bot; and Evi, an emotional buddy bot. We followed up with one-on-one interviews with the users discussing their experiences with each of the chatbots, what they liked, and what they did not. Overall our results show that users wanted a chatbot like Maya, who could add value to their life while being a friend, by making useful recommendations. But they also wanted preferred traits of Ada and Evi infused into Maya.
The etiologic role of HPV in vulvar squamous cell carcinoma fine tuned.

PURPOSE
High-risk human papilloma virus (HPV) plays a role in the development of a subset of vulvar squamous cell carcinomas. Uncertainty exists about the true impact of HPV in this tumor type because conflicting reports have been published with diverging prevalence rates. This study was done to fine tune the role of high-risk HPV infection in vulvar squamous cell carcinoma development in relation to clinical prognosis.


EXPERIMENTAL DESIGN
130 vulvar squamous cell carcinomas of patients with known survival data were analyzed for histology of the adjacent lesion (differentiated or HPV-associated usual vulvar intraepithelial neoplasia), in relation to p16(INK4A) expression as marker of HPV activity, and presence and integration of high-risk HPV DNA.


RESULTS
Usual vulvar intraepithelial neoplasia was present adjacent to vulvar squamous cell carcinoma in 25 of 130 cases. Usual vulvar intraepithelial neoplasia-associated squamous cell carcinomas had high p16(INK4A) expression, and 24 of 25 squamous cell carcinomas contained integrated high-risk HPV DNA. Differentiated vulvar intraepithelial neoplasia was found adjacent to 105 of 130 vulvar squamous cell carcinomas. High-risk HPV was detected in 11 (10.5%) differentiated vulvar intraepithelial neoplasia-associated vulvar squamous cell carcinoma but correlated with high p16(INK4A) expression in only one case. Integration of viral DNA was never observed in differentiated vulvar intraepithelial neoplasia-associated squamous cell carcinomas, which suggests that a causal relationship of high-risk HPV in differentiated vulvar intraepithelial neoplasia-associated tumors is highly unlikely. The disease-specific survival of the differentiated vulvar intraepithelial neoplasia-associated vulvar squamous cell carcinoma patients was significantly worse compared with patients with a usual vulvar intraepithelial neoplasia-associated tumor.


CONCLUSIONS
High-risk HPV is causally associated with the development of usual vulvar intraepithelial neoplasia associated squamous cell carcinomas, which comprise 19% of all vulvar squamous cell carcinomas, but not with differentiated vulvar intraepithelial neoplasia-associated vulvar squamous cell carcinomas. Differentiated vulvar intraepithelial neoplasia-associated vulvar squamous cell carcinomas have a significantly worse prognosis.
Long range forces from the cosmological neutrino background

Abstract The cosmological neutrino background will mediate long range forces between objects. For a background of temperature T , the potential decreases as 1 r 5 for r ⪢ 1 T and as 1 r for r ⪡ 1 T . These forces have large spin-dependent components. If the neutrino background is nonrelativistic, the long range forces are enhanced by a factor of the inverse neutrino velocity.
Late presentation of patients with cervical cancer to a tertiary hospital in Lagos: what is responsible?

OBJECTIVES
To determine the factors contributing to late presentation of patients with cervical cancer to a tertiary hospital in Lagos.


METHODS
Cervical cancer patients who attended the hospital between September 2000 and December 2001 were interviewed to determine the healthcare facilities visited at the onset of symptoms and time interval between presentation and referral.


RESULTS
There were 127 patients with a mean age of 54.6 +/- 13.4 years. Common symptoms at onset of disease were post-menopausal bleeding (55.9%) and vaginal discharge (48.8%). Of the patients, 60.7.1% first went to private hospitals. The interval between onset of symptoms and seeking healthcare was 6.10 +/- 9.31 months; time elapsing between seeking healthcare and referral to a tertiary hospital was 9.35 +/- 12.9 months. Stage 3A cervical cancer was diagnosed in 71.8%.


CONCLUSION
Patients' delay in seeking healthcare and care providers' delay in referring patients to a tertiary hospital contributed to the late presentation.
Pharmacokinetics of afatinib, a selective irreversible ErbB family blocker, in patients with advanced solid tumours.

BACKGROUND AND OBJECTIVE
Afatinib is a potent, irreversible, ErbB family blocker in clinical development for the treatment of a variety of solid tumours. This study evaluated the pharmacokinetics of afatinib (10-100 mg once daily) in cancer patients.


METHODS
Data from 221 patients with advanced solid tumours in four phase I and one phase II trial were analysed using non-compartmental methods.


RESULTS
Within each dose group, the shape of the geometric mean plasma concentration-time profiles after single and multiple doses were comparable. Maximum plasma concentration (C(max)) values were achieved 2-5 h after dosing and thereafter declined at least bi-exponentially. Steady-state plasma concentrations were attained within 8 days after the start of dosing. The geometric mean terminal elimination half-life at steady state was about 37 h. Repeated dosing resulted in a 2.77-fold accumulation based on the area under the plasma concentration-time curve (AUC), and 2.11-fold accumulation based on C(max) values. A slightly more than dose-proportional increase in afatinib exposure was observed. There was moderate intra-individual variability in afatinib trough concentration values (the geometric coefficient of variation (gCV) ranged from 22.2 to 67.5 %). The inter-patient variability in plasma concentrations was moderate to high (e.g. at the 40 mg dose, the gCVs ranged from 35.6 to 221 %). The exposure to afatinib (as measured by AUC and C(max)) correlated with the severity of the most common adverse events of afatinib--diarrhoea and rash.


CONCLUSION
The pharmacokinetic profile of afatinib supports a once-daily dosage regimen. As expected for this patient population, the pharmacokinetic parameters of afatinib showed moderate to high inter-patient variability. Afatinib exhibits non-linear pharmacokinetics.
Comparing unconscious processing during continuous flash suppression and meta-contrast masking just under the limen of consciousness

Stimuli can be rendered invisible using a variety of methods and the method selected to demonstrate unconscious processing in a given study often appears to be arbitrary. Here, we compared unconscious processing under continuous flash suppression (CFS) and meta-contrast masking, using similar stimuli, tasks and measures. Participants were presented with a prime arrow followed by a target arrow. They made a speeded response to the target arrow direction and then reported on the prime's visibility. Perception of the prime was made liminal using either meta-contrast masking (Experiment 1) or CFS (Experiments 2 and 3). Conscious perception of the prime was assessed using a sensitive visibility scale ranging from 0 to 3 and unconscious processing was measured as the priming effect on target discrimination performance of prime-target direction congruency when prime visibility was null. Crucially, in order to ensure that the critical stimuli were equally distant from the limen of consciousness, we sought stimulus and temporal parameters for which the proportion of 0-visibility trials was comparable for the two methods. We found that the method used to prevent conscious perception matters: unconscious processing was substantial with meta-contrast masking but absent with CFS. These findings suggest that CFS allows very little perceptual processing, if at all, and that previous reports of high-level and complex unconscious processing during CFS may result from partial awareness.
A Fast Loss and Temperature Simulation Method for Power Converters, Part II: 3-D Thermal Model of Power Module

This paper describes the development and implementation of an analytical 3-D thermal model for fast and accurate thermal simulation of power device modules in electrothermal converter simulation. A Fourier-based solution is used to solve the 3-D heat equation. The solution can describe the variation of temperature through the whole inverter power module structure as a function of time. The model can simulate thermal interactions resulting from multiple heat sources. The thermal model is extremely fast to simulate compared to finite-element (FEM) approaches. The new model has been implemented in MATLAB/Simulink in order to cosimulate with the converter model which is in the same form. The model has been validated against the computational fluid dynamics (CFD) software package FLOTHERM and shows good agreement. The required aspects of 3-D heat diffusion are captured successfully by the Fourier-based model.
UCC LibGuides: Engineering: Technical Writing Aids

Resources for chemical, civil, computer, electronics and electrical, mechanical, and robotics engineering. Writing suggestions for scientists and engineers.
Medical journal editors lacked familiarity with scientific publication issues despite training and regular exposure.

OBJECTIVE
To characterize medical editors by determining their demographics, training, potential sources of conflict of interest (COI), and familiarity with ethical standards.


STUDY DESIGN AND SETTING
We selected editors of clinical medical journals with the highest annual citation rates. One hundred eighty-three editors were electronically surveyed (response rate, 52%) on demographics and experiences with editorial training, publication ethics, industry, and scientific publication organizations.


RESULTS
Editors reported formal (76%) and informal (89%) training in medical editing topics. Most editors saw publication ethics issues (e.g., authorship, COIs) at least once a year. When presented with four questions about editorial issues discussed in commonly cited authoritative policy sources, performance was poor on topics of authorship (30% answered correctly), COI (15%), peer review (16%), and plagiarism (17%). Despite this, confidence level in editorial skills on a Likert scale from the beginning to the end of the survey dropped only slightly from 4.2 to 3.9 (P<0.0001).


CONCLUSION
Our study presents a current look at editors of major clinical medical journals. Most editors reported training in medical editing topics, saw ethical issues regularly, and were aware of scientific publication organizations, but their knowledge of four common and well-disseminated publication ethics topics appears poor.
Insulin analogue therapy improves quality of life in patients with type 2 diabetes in India: the A1chieve study.

AIMS
To determine the effects on quality of life after starting insulin with, or switching to, insulin analogue therapies in Indians with type 2 diabetes mellitus in the 24-week, prospective, observational A1chieve study.


METHODS
Health-related quality of life (HRQoL) was assessed at baseline and at 24 weeks by the validated EQ-5D questionnaire (visual analogue score [VAS] and five dimensions) in 20,554 people who had started using basal insulin detemir, mealtime insulin aspart (with or without a basal insulin) or biphasic insulin aspart 30.


RESULTS
Quality of life improved in both insulin-naive and insulin experienced patients in all treatment groups. At the start of the study, 63.2% of the insulin-naive patients reported problems with walking but after 24 weeks, only 15.2% reported difficulties. At baseline all HrQOL parameters were deteriorated in Indian cohort and the improvement observed was highly significant and well appreciated. The improvement was seen across all insulin regimen and all regions around India.


CONCLUSION
Compared with baseline scores, HRQoL improvement was seen after 24 weeks of treatment with all insulin analogue therapies
Pleistocene Mitochondrial Genomes Suggest a Single Major Dispersal of Non-Africans and a Late Glacial Population Turnover in Europe

How modern humans dispersed into Eurasia and Australasia, including the number of separate expansions and their timings, is highly debated [1, 2]. Two categories of models are proposed for the dispersal of non-Africans: (1) single dispersal, i.e., a single major diffusion of modern humans across Eurasia and Australasia [3-5]; and (2) multiple dispersal, i.e., additional earlier population expansions that may have contributed to the genetic diversity of some present-day humans outside of Africa [6-9]. Many variants of these models focus largely on Asia and Australasia, neglecting human dispersal into Europe, thus explaining only a subset of the entire colonization process outside of Africa [3-5, 8, 9]. The genetic diversity of the first modern humans who spread into Europe during the Late Pleistocene and the impact of subsequent climatic events on their demography are largely unknown. Here we analyze 55 complete human mitochondrial genomes (mtDNAs) of hunter-gatherers spanning ∼35,000 years of European prehistory. We unexpectedly find mtDNA lineage M in individuals prior to the Last Glacial Maximum (LGM). This lineage is absent in contemporary Europeans, although it is found at high frequency in modern Asians, Australasians, and Native Americans. Dating the most recent common ancestor of each of the modern non-African mtDNA clades reveals their single, late, and rapid dispersal less than 55,000 years ago. Demographic modeling not only indicates an LGM genetic bottleneck, but also provides surprising evidence of a major population turnover in Europe around 14,500 years ago during the Late Glacial, a period of climatic instability at the end of the Pleistocene.
Forecasting Exchange Rates Using Feedforward and Recurrent Neural Networks

JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range of content in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new forms of scholarship. For more information about JSTOR, please contact support@jstor.org. SUMMARY In this paper we investigate the out-of-sample forecasting ability of feedforward and recurrent neural networks based on empirical foreign exchange rate data. A two-step procedure is proposed to construct suitable networks, in which networks are selected based on the predictive stochastic complexity (PSC) criterion, and the selected networks are estimated using both recursive Newton algorithms and the method of nonlinear least squares. Our results show that PSC is a sensible criterion for selecting networks and for certain exchange rate series, some selected network models have significant market timing ability and/or significantly lower out-of-sample mean squared prediction error relative to the random walk model.
Genetic defects in PI3Kδ affect B-cell differentiation and maturation leading to hypogammaglobulineamia and recurrent infections.

BACKGROUND
Mutations in PIK3CD and PIK3R1 cause activated PI3K-δ syndrome (APDS) by dysregulation of the PI3K-AKT pathway.


METHODS
We studied precursor and peripheral B-cell differentiation and apoptosis via flowcytometry. Furthermore, we performed AKT-phosphorylation assays and somatic hypermutations (SHM) and class switch recombination (CSR) analysis.


RESULTS
We identified 13 patients of whom 3 had new mutations in PIK3CD or PIK3R1. Patients had low total B-cell numbers with increased frequencies of transitional B cells and plasmablasts, while the precursor B-cell compartment in bone marrow was relatively normal. Basal AKT phosphorylation was increased in lymphocytes from APDS patients and natural effector B cells where most affected. PI3K mutations resulted in altered SHM and CSR and increased apoptosis.


CONCLUSIONS
The B-cell compartment in APDS patients is affected by the mutations in PI3K. There is reduced differentiation beyond the transitional stage, increased AKT phosphorylation and increased apoptosis. This B-cell phenotype contributes to the clinical phenotype.
Comparative credit risk in Islamic and conventional bank

Article history: Received 2 September 2014 Accepted 9 June 2015 Available online 14 June 2015 In this paper, we consider the levels of credit risk in Islamic and conventional banks. One problemwith existing studies is the use of accounting information alone to assess credit risk, and this could be especially misleadingwith Islamic banking. Using amarket-based credit riskmeasure, Merton's distance-to-default (DD) model, we evaluate the credit risk of 156 conventional banks and 37 Islamic banks across 13 countries between 2000 and 2012. We also calculate the accounting informationbased Z-score and nonperforming loan (NPL) ratio for the purpose of comparison. Our results show that Islamic banks have significantly lower credit risk than conventional banks as based on DD. In contrast, and as expected, Islamic banks display much higher credit risk using the Z-score and NPL ratio. These findings suggest that the measure chosen plays a significant role in assessing the actual credit risk of Islamic banks. © 2015 Elsevier B.V. All rights reserved. JEL classification: G21 G32
Phase II study of combination chemotherapy of 5-fluorouracil, low-dose leucovorin, and oxaliplatin (FLOX regimen) in pretreated advanced gastric cancer.

BACKGROUND
This phase II study describes the efficacy and safety of combination chemotherapy of 5-fluorouracil (5-FU), low-dose leucovorin, and oxaliplatin (FLOX regimen) for pretreated advanced gastric cancer.


PATIENTS AND METHODS
Patients who had been previously treated with greater than or equal to one regimen were enrolled. Patients received an oxaliplatin 75 mg/m(2) on day 1, 5-FU 1000 mg/m(2) on days 1-3, and leucovorin 20 mg/m(2) on days 1-3, every 3 weeks. The primary end point was overall survival (OS).


RESULTS
Among the 52 patients enrolled, 26 patients were treated as second line, and the remaining 26 patients were enrolled as third- or fourth line. A total of 203 cycles of chemotherapy were administered with the median being three cycles (range 1-15) per patient. The median OS was 6.6 months [95% confidence interval (CI) 4.5-8.8] and the median progression-free survival was 2.5 months (95% CI 1.9-3.0). The response rate was 4% (95% CI 0-9%), and the disease control rate was 48% (95% CI 34-62%). The most common toxic effects of grade 3/4 were neutropenia (16%) and vomiting (6%).


CONCLUSIONS
The FLOX regimen showed modest activity as a salvage treatment in pretreated advanced gastric cancer with a favorable compliance.
Diabetic neuropathies: clinical manifestations and current treatment options

Diabetic neuropathies are a heterogeneous group of disorders that include a wide range of abnormalities. They can be focal or diffuse, proximal or distal, affecting both peripheral and autonomic nervous systems, causing morbidity with significant impact on the quality of life of the person with diabetes, and can result in early death. Distal symmetric polyneuropathy, the most common form of diabetic neuropathy, usually involves small and large nerve fibers. Small-nerve-fiber neuropathy often presents with pain but without objective signs or electrophysiologic evidence of nerve damage, and is recognized as a component of the impaired glucose tolerance and metabolic syndromes. The greatest risk resulting from small-fiber neuropathy is foot ulceration and subsequent gangrene and amputation. Large-nerve-fiber neuropathies produce numbness, ataxia and uncoordination, impairing activities of daily living and causing falls and fractures. A careful history and detailed physical examination are essential for the diagnosis. Symptomatic therapy has become available and newer and better treatment modalities, based on etiologic factors, are being explored with potential for significant impact on morbidity and mortality. Preventive strategies and patient education still remain key factors in reducing complication rates and mortality.
Twitter Sentiment Analysis: The Good the Bad and the OMG!

In this paper, we investigate the utility of linguistic features for detecting the sentiment of Twitter messages. We evaluate the usefulness of existing lexical resources as well as features that capture information about the informal and creative language used in microblogging. We take a supervised approach to the problem, but leverage existing hashtags in the Twitter data for building training data.