LLukas22/scidocs huggingface dataset:
CONSORT-EHEALTH: Improving and Standardizing Evaluation Reports of Web-based and Mobile Health Interventions

BACKGROUND
Web-based and mobile health interventions (also called "Internet interventions" or "ehealth/mhealth interventions") are tools or treatments, typically behaviorally based, that are operationalized and transformed for delivery via the Internet or mobile platforms. These include electronic tools for patients, informal caregivers, healthy consumers, and health care providers. The "Consolidated Standards of Reporting Trials" (CONSORT) was developed to improve the suboptimal reporting of randomized controlled trials (RCTs). While broadly the CONSORT statement can be applied to provide guidance on how ehealth and mhealth trials should be reported, RCTs of web-based interventions pose very specific issues and challenges, in particular related to reporting sufficient details of the intervention to allow replication and theory-building.


OBJECTIVE
To develop a checklist, dubbed CONSORT-EHEALTH (Consolidated Standards of Reporting Trials of Electronic and Mobile HEalth Applications and onLine TeleHealth), as an extension of the CONSORT statement that provides guidance for authors of ehealth and mhealth interventions.


METHODS
A literature review was conducted, followed by a survey among ehealth experts and a workshop.


RESULTS
An instrument and checklist was constructed as an extension of the CONSORT statement. The instrument has been adopted by the Journal of Medical Internet Research (JMIR) and authors of ehealth RCTs are required to submit an electronic checklist explaining how they addressed each subitem.


CONCLUSIONS
CONSORT-EHEALTH has the potential to improve reporting and provides a basis for evaluating the validity and applicability of ehealth trials. Subitems describing how the intervention should be reported can also be used for non-RCT evaluation reports. As part of the development process, an evaluation component is essential, therefore feedback from authors will be solicited, and a before-after study will evaluate whether reporting has been improved.
Theoretical studies on the electronic structure and optical absorption property of (Ni, C) co-doped anatase TiO2

Abstract Reducing the band gap of TiO 2 has a great potential in solar energy application. Among them, doping is a very effective method. We systematically study C/Ni mono-doped and (Ni, C) co-doped anatase TiO 2 , using density functional calculations. We first optimize the geometric structures with pseudopotential plane wave approach. Then on the optimized structure, we perform band-structure calculations with HSE06 hybrid functional calculation on the frame of Gaussian type of orbital. Therefore, we can obtain accurate band gaps close to experimental values if they exist at lower computation cost. Among three doped models, the Ni single doped model has the lowest impurity formation energy under reduction condition. Compared with the single doped models, (Ni, C) co-doped titanium dioxide has the smallest direct band gap, and the absorption band edge shows an apparent bigger red-shift. Through calculating the optical absorption spectra of several doped models in the visible light region (400–760 nm), (Ni, C) co-doped model can absorb much more visible light. Thus it has a much higher photocatalytic activity.
Making CNC machine tools more open, interoperable and intelligent - a review of the technologies

The aim of the next generation of computer numerically controlled (CNC) machines is to be portable, interoperable and adaptable. Over the years, G-codes (ISO 6983) have been extensively used by the CNC machine tools for part programming and are now considered as a bottleneck for developing next generation of CNC machines. A new standard known as STEP-NC is being developed as the data model for a new breed of CNC machine tools. The data model represents a common standard specifically aimed at the intelligent CNC manufacturing workstation, making the goal of a standardised CNC controller and NC code generation facility a reality. It is believed that CNC machines implementing STEP-NC will be the basis for a more open and adaptable architecture. This paper outlines a futuristic view of STEP-NC to support distributed interoperable intelligent manufacturing through global networking with autonomous manufacturing workstations with STEP compliant data interpretation, intelligent part program generation, diagnostics and maintenance, monitoring and job production scheduling. # 2005 Elsevier B.V. All rights reserved.
Densified Silicon Carbide-An Interesting Material for Diesel Applications

One class of ceramic materials that is being considered for application in diesel environment is the densified silicon carbide. The composition, microstructure, physical and mechanical properties of several members of this family of materials will be discussed along with illustrations of the current state of the art of component complexity. /SAE/
Effects of Prednisolone on Disease Progression in Antiretroviral-Untreated HIV Infection: A 2-Year Randomized, Double-Blind Placebo-Controlled Clinical Trial

BACKGROUND
HIV-disease progression correlates with immune activation. Here we investigated whether corticosteroid treatment can attenuate HIV disease progression in antiretroviral-untreated patients.


METHODS
Double-blind, placebo-controlled randomized clinical trial including 326 HIV-patients in a resource-limited setting in Tanzania (clinicaltrials.gov NCT01299948). Inclusion criteria were a CD4 count above 300 cells/μl, the absence of AIDS-defining symptoms and an ART-naïve therapy status. Study participants received 5 mg prednisolone per day or placebo for 2 years. Primary endpoint was time to progression to an AIDS-defining condition or to a CD4-count below 200 cells/μl.


RESULTS
No significant change in progression towards the primary endpoint was observed in the intent-to-treat (ITT) analysis (19 cases with prednisolone versus 28 cases with placebo, p = 0.1407). In a per-protocol (PP)-analysis, 13 versus 24 study participants progressed to the primary study endpoint (p = 0.0741). Secondary endpoints: Prednisolone-treatment decreased immune activation (sCD14, suPAR, CD38/HLA-DR/CD8+) and increased CD4-counts (+77.42 ± 5.70 cells/μl compared to -37.42 ± 10.77 cells/μl under placebo, p < 0.0001). Treatment with prednisolone was associated with a 3.2-fold increase in HIV viral load (p < 0.0001). In a post-hoc analysis stratifying for sex, females treated with prednisolone progressed significantly slower to the primary study endpoint than females treated with placebo (ITT-analysis: 11 versus 21 cases, p = 0.0567; PP-analysis: 5 versus 18 cases, p = 0.0051): No changes in disease progression were observed in men.


CONCLUSIONS
This study could not detect any significant effects of prednisolone on disease progression in antiretroviral-untreated HIV infection within the intent-to-treat population. However, significant effects were observed on CD4 counts, immune activation and HIV viral load. This study contributes to a better understanding of the role of immune activation in the pathogenesis of HIV infection.


TRIAL REGISTRATION
ClinicalTrials.gov NCT01299948.
Intra-articular injection of tranexamic acid reduce blood loss in cemented total knee arthroplasty

The purpose of this study was to compare the efficacy of intravenous and topical tranexamic acid (TXA) versus control group for reduction in blood loss following primary total knee arthroplasty (TKA). A total of 90 patients were prospectively allocated to each of three groups (control, intravenous IV and intra-articular) and underwent unilateral total knee arthroplasty. In the IV group, patients received one dose of TXA of 15 mg/kg before deflation of the tourniquet, while in the intra-articular group patients received 2 g TXA via the drain retrogradely after closure of the wound. The mean drained blood loss in control, IV and intra-articular groups was 415 ± 24, 192 ± 21 and 121 ± 17 ml, respectively. About 43 % (control), 23 % (IV) and 17 % (intra-articular) of each group required transfusion, and the mean transfusion was 338, 168 and 79 ml, respectively. Preoperative hemoglobin values decreased at 24 h by 2.80 ± 0.14, 2.24 ± 0.17 and 2.26 ± 0.18 mg/dl, respectively. TXA reduced blood loss and transfusion requirement. Compared with one-dose intravenous administration, intra-articular administration of TXA seems to be more effective in terms of reducing drained blood loss and transfusion frequency. We recommend administration of topical TXA in primary TKA in healthy patients to decrease perioperative blood loss.
Genome Analysis and Expression Patterns of Odorant-Binding Proteins from the Southern House Mosquito Culex pipiens quinquefasciatus

Olfactory-based behaviors in mosquitoes are mediated by odorant-binding proteins (OBPs). They form a multigenic family involved in the peripheral events in insect olfaction, specifically the transport of odorants to membrane-bound odorant receptors. OBPs contribute to the remarkable sensitivity of the insect's olfactory system and may be involved in the selective transport of odorants.We have employed a combination of bioinformatics and molecular approaches to identify and characterize members of the "classic" OBP family in the Southern House mosquito Culex pipiens quinquefasciatus ( = Cx. quinquefasciatus), a vector of pathogens causing several human diseases. By taking advantage of the recently released genome sequences, we have identified fifty-three putative Cx. quinquefasciatus OBP genes by Blast searches. As a first step towards their molecular characterization, expression patterns by RT-PCR revealed thirteen genes that were detected exclusively and abundantly in chemosensory tissues. No clear differences were observed in the transcripts levels of olfactory-specific OBPs between antennae of both sexes using semi-quantitative RT-PCR. Phylogenetic and comparative analysis revealed orthologous of Cx. quinquefasciatus OBPs in Anopheles gambiae and Aedes aegypti. The identification of fifty-three putative OBP genes in Cx. quinquefasciatus highlights the diversity of this family. Tissue-specificity study suggests the existence of different functional classes within the mosquito OBP family. Most genes were detected in chemosensory as well as non chemosensory tissues indicating that they might be encapsulins, but not necessarily olfactory proteins. On the other hand, thirteen "true" OBP genes were detected exclusively in olfactory tissues and might be involved specifically in the detection of "key" semiochemicals. Interestingly, in Cx. quinquefasciatus olfactory-specific OBPs belong exclusively to four distinct phylogenetic groups which are particularly well conserved among three mosquito species.
Water wave optimization: A new nature-inspired metaheuristic

Nature-inspired computing has been a hot topic in scientific and engineering fields in recent years. Inspired by the shallow water wave theory, the paper presents a novel metaheuristic method, named water wave optimization (WWO), for global optimization problems. We show how the beautiful phenomena of water waves, such as propagation, refraction, and breaking, can be used to derive effective mechanisms for searching in a high-dimensional solution space. In general, the algorithmic framework of WWO is simple, and easy to implement with a small-size population and only a few control parameters. We have tested WWO on a diverse set of benchmark problems, and applied WWO to a real-world high-speed train scheduling problem in China. The computational results demonstrate that WWO is very competitive with state-of-the-art evolutionary algorithms including invasive weed optimization (IWO), biogeography-based optimization (BBO), bat algorithm (BA), etc. The new metaheuristic is expected to have wide applications in real-world engineering optimization problems. & 2014 Elsevier Ltd. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-SA license (http://creativecommons.org/licenses/by-nc-sa/3.0/).
Protection of Identity Information in Cloud Computing without Trusted Third Party

Cloud computing allows the use of Internet-based services to support business processes and rental of IT-services on a utility-like basis. It offers a concentration of resources but also poses risks for data privacy. A single breach can cause significant loss. The heterogeneity of “users” represents a danger of multiple, collaborative threats. In cloud computing, entities may have multiple accounts associated with a single or multiple service providers (SPs). Sharing sensitive identity information (that is, Personally Identifiable information or PII) along with associated attributes of the same entity across services can lead to mapping of the identities to the entity, tantamount to privacy loss. Identity management (IDM) is one of the core components in cloud privacy and security and can help alleviate some of the problems associated with cloud computing. Available solutions use trusted third party (TTP) in identifying entities to SPs. The solution providers do not recommend the usage of their solutions on untrusted hosts. We propose an approach for IDM, which is independent of TTP and has the ability to use identity data on untrusted hosts. The approach is based on the use of predicates over encrypted data and multi-party computing for negotiating a use of a cloud service. It uses active bundle—which is a middleware agent that includes PII data, privacy policies, a virtual machine that enforces the policies, and has a set of protection mechanisms to protect itself. An active bundle interacts on behalf of a user to authenticate to cloud services using user’s privacy policies.
Acupuncture for low back pain: traditional diagnosis and treatment of 148 patients in a clinical trial.

AIMS
To assess patterns of diagnosis, including concordance, and treatment within a clinical trial of traditional acupuncture for low back pain.


SETTING
In a pragmatic randomised controlled clinical trial, 148 patients with low back pain, of between 4 weeks and 12 months duration, were randomised to the offer of individualised acupuncture and received up to 10 treatments.


METHODS
Standardised diagnosis and treatment records were completed by practitioners for 148 patients. The diagnosis was based on three pre-defined low back pain syndromes. For a subgroup of patients, one of the six practitioners then independently re-examined the patients, blind to the original diagnosis. The diagnostic inter-rater reliability was assessed in terms of percentage congruent classifications and Cohen's Kappa. Structured interviews of practitioners established further details about practice styles.


RESULTS
The most commonly diagnosed syndrome associated with low back pain was Qi and Blood Stagnation (88% of patients), followed by Kidney Deficiency (53%) and Bi Syndrome (28%), with more than one syndrome being identified for 65% of patients. For the subgroup examined twice, practitioner concordance was reasonable: between 47 and 80% of classifications were congruent, while Kappa values lay between 0 ("the same as chance") and 0.67 ("good"). Practitioners provided 1269 treatments in total, using 177 different acupuncture points. Most commonly used channels were Bladder and Gall Bladder, and the commonest points were BL-23 and the two lowest Huatuojiaji points. Auxiliary treatments were utilised by all practitioners to varying degrees.


CONCLUSIONS
Diagnostic concordance among practitioners was reasonable, and clear themes emerged for treatment. Further research is required to develop a flexible trial protocol with scope for individualised treatment.
Hypoglycaemic and Hypolipidaemic Effects of Withania somnifera Root and Leaf Extracts on Alloxan-Induced Diabetic Rats

Withania somnifera is an important medicinal plant, which is used in traditional medicine to cure many diseases. Flavonoids were determined in the extracts of W. somnifera root (WSREt) and leaf (WSLEt). The amounts of total flavonoids found in WSREt and WSLEt were 530 and 520 mg/100 g dry weight (DW), respectively. Hypoglycaemic and hypolipidaemic effects of WSREt and WSLEt were also investigated in alloxan-induced diabetic rats. WSREt and WSLEt and the standard drug glibenclamide were orally administered daily to diabetic rats for eight weeks. After the treatment period, urine sugar, blood glucose, haemoglobin (Hb), glycosylated haemoglobin (HbA1C), liver glycogen, serum and tissues lipids, serum and tissues proteins, liver glucose-6-phosphatase (G6P) and serum enzymes like aspartate transaminase (AST), alanine transaminase (ALT), acid phosphatase (ACP) and alkaline phosphatase (ALP) levels were determined. The levels of urine sugar, blood glucose, HbA1C, G6P, AST, ALT, ACP, ALP, serum lipids except high density lipoprotein-bound cholesterol (HDL-c) and tissues like liver, kidney and heart lipids were significantly (p < 0.05) increased, however Hb, total protein, albumin, albumin:globulin (A:G) ratio, tissues protein and glycogen were significantly (p < 0.05) decreased in alloxan-induced diabetic rats. Treatment of the diabetic rats with WSREt, WSLEt and glibenclamide restored the changes of the above parameters to their normal level after eight weeks of treatment, indicating that WSREt and WSLEt possess hypoglycaemic and hypolipidaemic activities in alloxan-induced diabetes mellitus (DM) rats.
Changes in cardiac sympathetic nerve innervation and activity in pathophysiologic transition from typical to end-stage hypertrophic cardiomyopathy.

UNLABELLED
Left ventricular (LV) systolic function in hypertrophic cardiomyopathy (HCM) is usually normal. Late in the disease, however, LV systolic dysfunction and dilatation are recognized. Although abnormalities in cardiac sympathetic nerve activity in patients with HCM have been demonstrated using (123)I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy, the changes of cardiac sympathetic nerve activity throughout the clinical course from typical to end-stage HCM are unclear. The objective of this study was to evaluate the relationship between abnormalities on (123)I-MIBG myocardial scintigraphy and pathophysiologic changes in patients with HCM.


METHODS
We performed (123)I-MIBG scintigraphy on 46 patients with HCM and 18 age-matched control subjects. The patients were categorized into 3 groups: 28 patients with normal LV systolic function (group A), 9 patients with LV systolic dysfunction (group B), and 9 patients with LV systolic dysfunction and dilatation (group C). With planar (123)I-MIBG imaging, the heart-to-mediastinum ratio for early and delayed acquisitions and the washout rate were calculated. With SPECT, polar maps of the LV myocardium were divided into 20 segments. The regional uptake and washout rate were calculated from semiquantitative 20-segment bull's-eye analysis.


RESULTS
The early uptake was significantly lower in group C than in the control group (P < 0.01). The washout rate was progressively higher in group A, group B, and group C (P < 0.01). Reduced regional early uptake was found in 2.9 +/- 3.4 (group A), 4.1 +/- 4.7 (group B), and 7.4 +/- 4.3 (group C) segments, respectively. In group C, regional early uptake was significantly reduced, predominantly in the interventricular septal wall, and regional washout rate was increased in the apex and lateral wall.


CONCLUSION
These results suggest that cardiac sympathetic nerve abnormalities in patients with HCM may advance with development of LV systolic dysfunction and dilatation and that (123)I-MIBG myocardial scintigraphy may be a useful tool for the evaluation of pathophysiologic changes in HCM.
Hacking Mobile Phones Using 2 D Printed Fingerprints

Fingerprint is the most popular biometric trait due to the perceived uniqueness and persistence of friction ridge pattern on human fingers [1]. Following the introduction of iPhone 5S with Touch ID fingerprint sensor in September 2013, most of the mobile phones, such as iPhone 5s/6/6+, Samsung Galaxy S5/S6, HTC One Max, Huawei Honor 7, Meizu MX4 Pro and others, now come with embedded fingerprint sensors for phone unlock. It has been forecasted that 50% of smartphones sold by 2019 will have an embedded fingerprint sensor [2]. With the introduction of Apple Pay, Samsung Pay and Android Pay, fingerprint recognition on mobile devices is leveraged for more than just for device unlock; it can also be used for secure mobile payment and other transactions.
Calculating Medium and Image Gamut Boundaries for Gamut Mapping

The Segment Maxima Method for calculating gamut boundary descriptors of both colour reproduction media and colour images is introduced. Methods for determining the gamut boundary along a given line of mapping used by gamut mapping algorithms are then described, whereby these methods use the Gamut Boundary Descriptor obtained using the Segment Maxima Method. Throughout the article, the focus is both on colour reproduction media and colour images as well as on the suitability of the methods for use in gamut mapping. © 2000 John Wiley & Sons, Inc. Col Res Appl, 25, 394–401, 2000
Effects of salinity on the contents of polyamines and some other compounds in sunflower plants differing in salt tolerance

The effects of salt stress (50, 100, and 150 mM NaCl) on the levels of free, bound, and total polyamines were studied in the leaf tissues of salt-tolerant (Coban) and salt-sensitive (Sanbro) cultivars of sunflower (Helianthus annuus L.) plants grown for 15 or 25 days under salinity. The amounts of free, acid-soluble bound, and total spermine increased in leaf tissues of sunflower plants subjected to salt stress while the levels of other polyamines decreased or no significant changes occurred. The increase in some PA titers suggests their potential role in overcoming the adverse effect of salinity stress. The salt sensitivity of the sunflower plants was associated with the excessive accumulation of total polyamines in the leaf tissues of salt-sensitive cultivar (Sanbro) under saline condition. The content of other compounds such as proline, protein, and ions (Na+, K+, Cl-, K+/Na+) in leaf tissue changed depending on salt concentration and the cultivars used.
Does dissociation moderate treatment outcomes of narrative exposure therapy for PTSD? A secondary analysis from a randomized controlled clinical trial.

UNLABELLED
Dissociative symptoms, especially depersonalisation and derealisation, are often perceived as a contraindication for exposure-based treatments of posttraumatic stress disorder (PTSD) despite limited empirical evidence. The present paper examines whether derealisation and depersonalisation influence the treatment outcomes of narrative exposure therapy (NET) and treatment as usual (TaU) among severely traumatised asylum seekers and refugees. We performed a secondary analysis of a recently published randomized controlled multicentre trial comparing NET and TaU for the treatment of PTSD in asylum seekers and refugees. In order to investigate whether depersonalisation and derealisation moderate treatment outcomes, a number of moderated multiple, blockwise regression analyses were conducted. Missing data were handled with multiple imputation. The main finding from intention-to-treat analyses is that derealisation and depersonalisation overall do not moderate the treatment outcomes of either NET or TaU. The treatment condition was the most stable predictor of residual gain scores across outcome measures, with NET being associated with lower residual gain scores indicating better treatment outcomes. The present study substantiates and extends previous research indicating that dissociative symptoms such as derealisation and depersonalisation do not moderate the treatment outcome of exposure-based treatments for PTSD.


CLINICALTRIALSGOV IDENTIFIER
NCT00218959.