LLukas22/scidocs huggingface dataset:
Dynamic modeling and stabilization of wheeled mobile robot

This paper presents the dynamic modeling of a nonholonomic mobile robot and the dynamic stabilization problem. The dynamic model is based on the kinematic one including nonholonomic constraints. The proposed control strategy allows to solve the control problem using linear controllers and only requires the robot localization coordinates. This strategy was tested by simulation using Matlab-Simulink. Key-words: Mobile robot, kinematic and dynamic modeling, simulation, point stabilization problem.
Prevalence, nature and predictors of prescribing errors in mental health hospitals: a prospective multicentre study

OBJECTIVE
To determine the prevalence, nature and predictors of prescribing errors (PEs) in three mental health hospitals.


SETTING
Inpatient units in three National Health Service (NHS) mental health hospitals in the North West of England.


PARTICIPANTS
Trained clinical pharmacists prospectively recorded the number of PEs in newly written or omitted prescription items screened during their routine work on 10 data collection days. A multidisciplinary panel reviewed PE data using established methods to confirm (1) the presence of a PE, (2) the type of PE and (3) whether errors were clinically relevant and likely to cause harm.


PRIMARY OUTCOME MEASURES
Frequency, nature and predictors of PEs.


RESULTS
Of 4427 screened prescription items, 281 were found to have one or more PEs (error rate 6.3% (95% CI 5.6 to 7.1%)). Multivariate analysis revealed that specialty trainees (OR 1.23 (1.01 to 1.51)) and staff grade psychiatrists (OR 1.50 (1.05 to 2.13)) were more likely to make PEs when compared to foundation year (FY) one doctors, and that specialty trainees and consultant psychiatrists were twice as likely to make clinically relevant PEs (OR 2.61 (2.11 to 3.22) and 2.03 (1.66 to 2.50), respectively) compared to FY one staff. Prescription items screened during the prescription chart rewrite (OR 0.52 (0.33 to 0.82)) or at discharge (OR 0.87 (0.79 to 0.97)) were less likely to be associated with PEs than items assessed during inpatient stay, although they were more likely to be associated with clinically relevant PEs (OR 2.27 (1.72 to 2.99) and 4.23 (3.68 to 4.87), respectively). Prescription items screened at hospital admission were five times more likely (OR 5.39 (2.72 to 10.69)) to be associated with clinically relevant errors than those screened during patient stay.


CONCLUSIONS
PEs may be more common in mental health hospitals than previously reported and important targets to minimise these errors have been identified.
The superiorly based nasolabial flap for simultaneous alar and cheek reconstruction.

LEARNING OBJECTIVES
After studying this article, the participant should be able to: 1. Understand the epidemiology of skin cancer in a patient with preexisting skin cancer. 2. Understand the indications for the use of a nasolabial flap and nonanatomic alar strut graft. 3. Describe the blood supply to the nasolabial flap. The goals of reconstructing deformities of the face acquired secondary to skin tumors include optimizing donor-site aesthetics and reconstructing the area with similar types of tissue when possible. Multiple skin-cancer defects are often seen by the plastic surgeon and complicate the reconstruction, requiring more than one flap or skin graft. A case analysis of an innovative application of the nasolabial flap for reconstruction of a simultaneous medial cheek and alar-base nasal defect is presented. Concepts in nasal reconstruction are reviewed, and the authors' approach to alar reconstruction is presented.
Lane detection using Fourier-based line detector

In this paper a new approach to lane marker detection problem is introduced as a significant complement for a semi/fully autonomous driver assistance system. The method incorporates advance line detection using multilayer fractional Fourier transform (MLFRFT) and the state-of-the-art advance lane detector (ALD). Experimental results have shown a considerable reduction in computational complexity.
Corpus callosum infarction with cognitive dysfunction: two case reports and literature review

Introduction
The incidence of corpus callosum infarction is low, and sudden cognitive dysfunction caused by corpus callosum infarction is very rare. We report two cases of acute corpus callosum infarction with sudden cognitive impairment, and the related basis, clinical manifestations, diagnosis, differential diagnosis, treatment, and prognosis of this disease are reviewed.


Cases presentation
The two patients had sudden and severe memory impairment and spatial orientation disorder. Their cognitive function scores were significantly lower, and their MRI demonstrated clear corpus callosum infarction. Through treatment, the symptoms improved significantly.


Discussion
This paper reports two cases with corpus callosum infarction with sudden cognitive impairment, and its relevant background is also reviewed, which will help doctors with the classification diagnosis of cerebral infarction and understanding of corpus callosum infarction.
STUDIES ON BUD BLIGHT DISEASE OF TOMATO CAUSED BY GROUNDNUT BUD NECROSIS VIRUS

Bud blight disease on tomato caused by groundnut bud necrosis virus (GBNV) is most important viral diseases of tomato in Karnataka and causes severe losses every year belongs to genus Tospovirus and the family Bunyaviridae. The survey was undertaken in parts of Belgaum, Dharwad, Haveri and Kolar districts during summer 2008. The bud blight was present in all the places where survey was carried out, the disease incidence ranged from 12.5 to 94.4%. The GBNV was mechanically transmitted. Cowpea, Datura, Chenopodium and Petunia were found to be good assay hosts. In the host range studies, 28 plant species tested, 14 were local lesion hosts, nine were local systemic hosts, two were systemic latent hosts and three were non-hosts. The GBNV was transmitted by Thrips palmi. The GBNV was detected by DAC-ELISA. The GBNV coat protein gene was amplified by RT-PCR. The sequenced region contained 831 nucleotides potentially code for a coat protein of 276 amino acids. Electron microscopy studies showed spherical of 80-100 nm diameter particle size. The effect of coconut and sorghum leaf extracts were studied to know the antiviral properties through induced systemic resistance (ISR). Spray of leaf extracts after 48 hours of inoculation, there was high ISR activities through higher production of PAL, PO, PPO compared to just inoculated plants. Of the 22 tomato varieties screened for resistance under field conditions, none of the genotypes showed resistant reactions. In the management of GBNV in tomato, the seed treatment with imidachloprid (0.005%) followed by spray of interpid (0.5%), acetamiprid (0.02%), thiomethoxam (0.05%) found effective with low disease incidence (34.09) compared to control (92.22). Sequence homology with GBNV of other isolates indicated that the present bud blight disease caused by GBNV on tomato can be tentatively designated as a strain of groundnut bud necrosis virus on tomato.
Kaposi sarcoma in unusual locations

Kaposi sarcoma (KS) is a multifocal, vascular lesion of low-grade malignant potential that presents most frequently in mucocutaneous sites. KS also commonly involves lymph nodes and visceral organs. This article deals with the manifestation of KS in unusual anatomic regions. Unusual locations of KS involvement include the musculoskeletal system, central and peripheral nervous system, larynx, eye, major salivary glands, endocrine organs, heart, thoracic duct, urinary system and breast. The development of KS within wounds and blood clots is also presented. KS in these atypical sites may prove difficult to diagnose, resulting in patient mismanagement. Theories to explain the rarity and development of KS in these unusual sites are discussed.
Factors Influencing Perceptions and Attitudes of Nurses Towards the Use of ICT in Patient Care in KwaZulu Natal Province, South Africa

This paper presents the results of a study to determine factors influencing perceptions and attitudes of nurses towards the use of ICT in 16 hospitals in KwaZulu-Natal (KZN) province, South Africa. Data were collected through a survey questionnaire and factor analysis performed to extract relevant variables. Overall, results revealed positive dispositions of nurses towards the use of ICT. Results further revealed self-efficacy, adoption of computers to improve nursing care, confidence in using computers, usefulness, interactability and knowledgeability were major factors influencing perceptions and attitudes of nurses towards use of ICT at the work place. Findings may inform institutional and provincial ICT infrastructure development decisions to improve nursing services in hospitals. Theoretically, the study provides an understanding of factors influencing attitudes and perceptions of nurses in the use of ICT at the workplace in a developing country context such as South Africa, and also in vast rural province such as KZN.
Social Constructionism and Ethics: What Makes a “Better” Story?

This article examines narrative and constructivist approaches to clinical work asking how we decide what makes a “better” story. It explores the educator's role in helping students learn to balance respect for unique and diverse accounts with the profession's commitment to social justice, objectively defined.
The Market Impact of a Limit Order

Despite their importance in modern electronic trading, virtually no systematic empirical evidence on the market impact of incoming orders is existing. We quantify the short-run and long-run price effect of posting a limit order by proposing a high-frequency cointegrated VAR model for ask and bid quotes and several levels of order book depth. Price impacts are estimated by means of appropriate impulse response functions. Analyzing order book data of 30 stocks traded at Euronext Amsterdam, we show that limit orders have significant market impacts and cause a dynamic (and typically asymmetric) rebalancing of the book. The For helpful comments and discussions we thank Ulrich Horst, Lada Kyj, Roel Oomen and the participants of the Conference on “Individual Decision Making, High Frequency Econometrics and Limit Order Book Dynamics” in Warwick, 2009, as well as of workshops at the Humboldt-Universität zu Berlin and at the Quantitative Products Laboratory. This research is supported by the Deutsche Bank AG via the Quantitative Products Laboratory and the Deutsche Forschungsgemeinschaft (DFG) via the Collaborative Research Center 649 “Economic Risk”. Institute for Statistics and Econometrics and Center for Applied Statistics and Economics (CASE), Humboldt-Universität zu Berlin as well as Quantitative Products Laboratory (QPL), Berlin, and Center for Financial Studies (CFS), Frankfurt. Email: nikolaus.hautsch@wiwi.hu-berlin.de. Address: Spandauer Str. 1, D-10178 Berlin, Germany. Quantitative Products Laboratory (QPL), Berlin and Institute for Statistics and Econometrics, Humboldt-Universität zu Berlin. Email: ruihong.huang@db.com. Address: Alexander Str. 5, D-10178 Berlin, Germany.
Accuracy of ambulatory blood pressure monitors: a systematic review of validation studies.

BACKGROUND
Recent research and guidelines recommend the routine use of ambulatory blood pressure monitoring for the diagnosis of hypertension, so accuracy of such monitors is more important than ever.


AIM
: To systematically review the literature regarding the accuracy of ambulatory monitors currently in use.


METHODS
Medline, Embase, Cinahl, the Cochrane database, Medion and the dabl Educational Trust website were searched until February 2011. No language or publication date limits were applied. Data were extracted separately by two independent reviewers. Methodological quality was assessed by whether a validation protocol had been used and followed correctly.


RESULTS
From 5420 journal articles identified, 108 met the inclusion criteria. Excluding studies assessing monitors no longer in use, 40 relevant studies were found using 21 different monitors. Thirty-eight (95%) studies used a validation protocol of which 28 studies assessed a monitor in the general population. Of these, protocols were passed in 24 of 28 studies, but 12 of 24 (50%) found a difference of at least 5 mmHg systolic between the test device and the reference standard for 30% or more of the readings. Of the 10 studies conducted in special population groups (e.g. pregnancy, elderly people), only four devices passed the protocols. Only six (16%) studies correctly adhered to the protocols.


CONCLUSION
Published validation studies assessed most ambulatory monitors as accurate, but many failed to adhere to the underlying protocols, undermining this conclusion and peer review standards. Furthermore, most monitors which 'passed' validation showed significant variation in blood pressure from the reference standard, highlighting inadequacies in older validation protocols. Future validation studies should use protocols with simpler methodologies but more rigorous accuracy criteria.
Comparison of a Stratified Group Intervention (STarT Back) With Usual Group Care in Patients With Low Back Pain: A Nonrandomized Controlled Trial.

STUDY DESIGN
A nonrandomized controlled trial.


OBJECTIVE
This study aims to explore the effectiveness of group-based stratified care in primary care.


SUMMARY OF BACKGROUND DATA
Stratified care based on psychosocial screening (STarT Back) has demonstrated greater clinical and cost-effectiveness in patients with low back pain. However, low back pain interventions are often delivered in groups and evaluating this system of care in a group setting is important.


METHODS
Patients were recruited from 60 general practices and linked physiotherapy services. A new group stratified intervention was compared with a historical nonstratified control group. Patients stratified as low, medium and high risk were offered risk-matched group care. Consenting participants completed self-report measures of functional disability (primary outcome measure), pain, psychological distress, and beliefs. The historical control received a generic group intervention. Analysis was by intention to treat.


RESULTS
In total, 251 patients in the new stratified intervention and 332 in the historical control were included in the primary analysis at 12 weeks. The mean age of patients was 43 ± 10.98 years. Overall adjusted mean changes in the RMDQ scores were higher in the stratified intervention than in the control arm at 12-week follow-up (P = 0.028). Exploring the risk groups, individually the high-risk stratified group, demonstrated better outcome over the controls (P = 0.031). The medium-risk stratified intervention demonstrated equally good outcomes (P = 0.125), and low-risk stratified patients, despite less intervention, did as well as the historical controls (P = 0.993).


CONCLUSION
Stratified care delivered in a group setting demonstrated superior outcomes in the high-risk patients, and equally good outcomes for the medium and low-risk groups. This model, embedded in primary care, provides an early and effective model of chronic disease management and adds another dimension to the utility of the STarT Back system of care.


LEVEL OF EVIDENCE
2.
Sympathoinhibition by atorvastatin in hypertensive patients.

BACKGROUND
Experimental animal data suggest that 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) might reduce enhanced sympathetic activity, a hallmark of hypertensive patients. This hypothesis was tested for the first time in patients with primary hypertension.


METHODS AND RESULTS
Using a prospective, randomized, placebo-controlled, double-blind, cross-over design, a proof-of-principle trial was performed in 13 patients with mild to moderate primary hypertension, who were randomly assigned to a regimen of atorvastatin (80mg/day) for 3 weeks, followed by placebo for 3 weeks or to a regimen of placebo for 3 weeks, followed by atorvastatin (80mg/day) for 3 weeks. Microneurography was used at the end of each treatment period to measure sympathetic nervous system activity (muscle sympathetic nerve activity: MSNA). Heart rate variability (HRV) and plasma norepinephrine concentrations were also measured. Additionally, effects on blood pressure (BP) and heart rate (HR) were assessed by 24-h ambulatory BP measurement. Atorvastatin reduced postganglionic MSNA (atorvastatin 35.0±2.0 vs placebo: 39.2±1.5 bursts/min, P=0.008) and heart frequency corrected MSNA (atorvastatin: 58.5±2.0 vs placebo: 64.7±3.0 bursts/100 beats, P=0.02). Atorvastatin had no significant effect on plasma norepinephrine levels, HRV, BP or HR.


CONCLUSIONS
In patients with mild to moderate hypertension, atorvastatin reduces postganglionic MSNA, which supports the hypothesis that HMG-CoA reductase plays a role in sympathetic nervous system activity.
On Modern Deep Learning and Variational Inference

Bayesian modelling and variational inference are rooted in Bayesian statistics, and easily benefit from the vast literature in the field. In contrast, deep learning lacks a solid mathematical grounding. Instead, empirical developments in deep learning are often justified by metaphors, evading the unexplained principles at play. It is perhaps astonishing then that most modern deep learning models can be cast as performing approximate variational inference in a Bayesian setting. This mathematically grounded result, studied in Gal and Ghahramani [1] for deep neural networks (NNs), is extended here to arbitrary deep learning models. The implications of this statement are profound: we can use the rich Bayesian statistics literature with deep learning models, explain away many of the curiosities with these, combine results from deep learning into Bayesian modelling, and much more. We demonstrate the practical impact of the framework with image classification by combining Bayesian and deep learning techniques, obtaining new state-of-the-art results, and survey open problems to research. These stand at the forefront of a new and exciting field combining modern deep learning and Bayesian techniques.
Women's preferences for male behavioral displays change across the menstrual cycle.

Women prefer both the scent of symmetrical men and masculine male faces more during the fertile (late follicular and ovulatory) phases of their menstrual cycles than during their infertile (e.g., luteal) phases. Men's behavioral displays in social settings may convey signals that affect women's attraction to men even more strongly. This study examined shifts in women's preferences for these behavioral displays. A sample of 237 normally ovulating women viewed 36 or 40 videotaped men who were competing for a potential lunch date and then rated each man's attractiveness as a short-term and a long-term mate. As predicted, women's preference for men who displayed social presence and direct intrasexual competitiveness increased on high-fertility days relative to low-fertility days, but only in a short-term, not a long-term, mating context. These findings add to the growing literature indicating that women's mate preferences systematically vary across the reproductive cycle.
The effects of a low-fat, plant-based dietary intervention on body weight, metabolism, and insulin sensitivity.

PURPOSE
This study investigated the effect of a low-fat, plant-based diet on body weight, metabolism, and insulin sensitivity, while controlling for exercise in free-living individuals.


SUBJECTS AND METHODS
In an outpatient setting, 64 overweight, postmenopausal women were randomly assigned to a low-fat, vegan diet or a control diet based on National Cholesterol Education Program guidelines, without energy intake limits, and were asked to maintain exercise unchanged. Dietary intake, body weight and composition, resting metabolic rate, thermic effect of food, and insulin sensitivity were measured at baseline and 14 weeks.


RESULTS
Mean +/- standard deviation intervention-group body weight decreased 5.8 +/- 3.2 kg, compared with 3.8 +/- 2.8 kg in the control group (P = .012). In a regression model of predictors of weight change, including diet group and changes in energy intake, thermic effect of food, resting metabolic rate, and reported energy expenditure, significant effects were found for diet group (P < .05), thermic effect of food (P < .05), and resting metabolic rate (P < .001). An index of insulin sensitivity increased from 4.6 +/- 2.9 to 5.7 +/- 3.9 (P = .017) in the intervention group, but the difference between groups was not significant (P = .17).


CONCLUSION
Adoption of a low-fat, vegan diet was associated with significant weight loss in overweight postmenopausal women, despite the absence of prescribed limits on portion size or energy intake.
Correlating chemical sensitivity and basal gene expression reveals mechanism of action

Changes in cellular gene expression in response to small-molecule or genetic perturbations have yielded signatures that can connect unknown mechanisms of action (MoA) to ones previously established. We hypothesized that differential basal gene expression could be correlated with patterns of small-molecule sensitivity across many cell lines to illuminate the actions of compounds whose MoA are unknown. To test this idea, we correlated the sensitivity patterns of 481 compounds with ∼19,000 basal transcript levels across 823 different human cancer cell lines and identified selective outlier transcripts. This process yielded many novel mechanistic insights, including the identification of activation mechanisms, cellular transporters and direct protein targets. We found that ML239, originally identified in a phenotypic screen for selective cytotoxicity in breast cancer stem-like cells, most likely acts through activation of fatty acid desaturase 2 (FADS2). These data and analytical tools are available to the research community through the Cancer Therapeutics Response Portal.
A new approach to teaching information technologies: shifting emphasis from technology to information

Being aware of the increasing pedagogical challenges posed by using and teaching IT in schools, we at the Technical University of Munich have started a widespread initiative to improve the practice of teaching IT in the secondary schools of Bavaria. We offer a curriculum to students who intend to become secondary school teachers. The goal of the curriculum is to establish a more abstract point of view, leaving the narrow hardand software-specific approaches schools have mostly followed until now. Guided by the development-process of software, we are proposing to concentrate on modeling techniques, especially in their object-oriented versions. Furthermore, we intend to install as many teachers with a complete university-level education in computer-science in the schools as possible. To that end we have developed a new, lean curriculum for the education of teachers, which also serves as a basis for an in-service training concept. In addition, we plan to improve the access of schools to modern information technologies. We succeeded in building up an Internet-node for a variety of country-site schools in Rosenheim.
Impact Factor, h-index, i10-index and i20-index of Webology

The purpose of this editorial note was to conduct a citation analysis of the Webology journal in order to show the journal impact factor, h-index, i10-index, i20-index, and patent citations. This note indicates to what extent the Webology journal is used and cited by the international scientific community. The results show that the total number of citations to Webology papers on Google Scholar was 2423 and the total number of citations received by i20 papers (i.e., 24 papers with at least 20 citations) was 1693. This reveals that i20 papers received 70 percent of all citations to Webology.