LLukas22/scidocs huggingface dataset:
The effect of body position on arterial oxygen saturation in acute stroke.

BACKGROUND
Evidence suggests that respiratory function is impaired poststroke. Body position is known to influence respiratory function in normal subjects and those with respiratory pathologies. Its effect on respiratory function after stroke has received little attention. However, one study suggests that some positions used in clinical practice may adversely influence respiratory function. This study therefore aimed to identify resting positions that maintain arterial oxygen saturation (SaO2) at optimal levels, changes in SaO2 during time spent in the test position, and differences in SaO2 among the positions investigated.


METHOD
A within-subject, two-center clinical study was made. Patients in the first 72 hours following mild to moderately severe stroke were allocated a randomized sequence of four positions. One hour was spent in each position. SaO2 was recorded each minute by pulse oximetry with a finger probe. Mean values for the hour were calculated.


RESULTS
Mean arterial oxygen saturation values for all patients were >90% for the hour spent in each test position for all patients. There were no changes in arterial oxygen saturation across the hour spent in the test positions (repeated-measures analysis of variance). No differences in arterial oxygen saturation were identified among positions (analysis of covariance).


DISCUSSION
The saturation levels recorded corresponded to those observed in studies of normal elderly persons. The positions tested may be recommended for use in clinical practice to maintain arterial oxygen saturation in patients in the first 72 hours following mild to moderately severe stroke.
The NIMA method for improved moment estimation from doppler spectra

The NCAR Improved Moments Algorithm (NIMA) for estimating moments from wind measurement devices that measure Doppler spectra as a function of range is described in some detail. Although NIMA’s main application has been for real-time processing of wind profiler data, it has also been successfully applied to Doppler lidar and weather radar data. Profiler spectra are often contaminated by a variety of sources including aircraft, birds, velocities exceeding the Nyquist velocity, radio frequency interference, and ground clutter. The NIMA method uses mathematical analysis, fuzzy logic synthesis, and global image processing algorithms to mimic human experts’ ability to identify atmospheric signals in the presence of such contaminants. NIMA is configurable and its processing can be tuned to optimize performance for a given profiler site. Once configured, NIMA is a fully automated algorithm that runs in real time to produce Doppler moments and a confidence assessment of those moments. These confidence values are useful in the generation and assessment of wind and turbulence estimates and are important when these quantities are used in critical situations such as airport operations. A simulation study is used to compare NIMA performance with that of a simple peak picking algorithm in the presence of ground clutter, RFI, and point targets. Some performance results for the NIMA confidence algorithm are also
A spreadsheet approach to programming and managing sensor networks

We present a spreadsheet approach to simplifying the process of managing, programming, and interacting with sensor networks and visualizing, archiving and retrieving sensor data. An Excel spreadsheet prototype has been built to demonstrate the idea. This environment provides Excel users, who are already familiar with spreadsheet applications, a convenient and powerful tool for programming and data analysis. We discuss the architecture of this prototype and our experience in implementing the tool. We show two different classes of sensor-net applications built using this platform. We also present performance data on the scalability of the tool with respect to data rate and number of data streams.
Personal health records for patients with chronic disease: a major opportunity.

BACKGROUND
Personal health records (PHRs) connected to a physician's electronic health record system hold substantial promise for supporting and engaging patients with chronic disease.


OBJECTIVES
To explore how U.S. health care organizations are currently utilizing PHRs for chronic disease populations.


METHODS
A mixed methods study including semi-structured interviews and a questionnaire was conducted. A purposive sample was developed of health care organizations which were recognized as exemplars for PHRs and were high performers in national patient satisfaction surveys (H-CAHPS or CAHPS). Within each organization, participants were health IT leaders or those managing high-risk or chronic disease populations.


RESULTS
Interviews were conducted with 30 informants and completed questionnaires were received from 16 organizations (84% response rate). Most PHRs allowed patients to access health records and educational material, message their provider, renew prescriptions and request appointments. Patient generated data was increasingly being sought and combined with messaging, resulted in greater understanding of patient health and functioning outside of the clinic visit. However for chronic disease populations, there was little targeted involvement in PHR design and few tools to help interpret and manage their conditions beyond those offered for all. The PHR was largely uncoupled from high risk population management interventions and no clear framework for future PHR development emerged.


CONCLUSION
This technology is currently underutilized and represents a major opportunity given the potential benefits of patient engagement and shared decision making. A coherent patient-centric PHR design and evaluation strategy is required to realize its potential and maximize this natural hub for multidisciplinary care co-ordination.
Oral and intraperitoneal LD50 of thymoquinone, an active principle of Nigella sativa, in mice and rats.

BACKGROUND
Thymoquinone is the major active principle of Nigella sativa (N. sativa) and constitutes about 30% of its volatile oil or ether extract. N. sativa oil and seed are commonly used as a natural remedy for many ailments. Using modern scientific techniques, a number of pharmacological actions of N. sativa have been investigated including immunostimulant, anti-inflammatory, anticancer, antioxidant, antihistaminic, antiasthmatic, hypoglycemic, antimicrobial and antiparasitic. There are only few reports regarding the toxicity of thymoquinone.


METHODS
The present study was carried out to determine LD50 of thymoquinone both in mice and rats, orally as well as intraperitoneall, by the method of Miller and Tainter. Autopsy and histopathology of liver, kidney, heart and lungs were also determined.


RESULTS
The LD50 in mice after intraperitoneal injection was determined to be 104.7 mg/kg (89.7-119.7, 95% confidence interval) and after oral ingestion was 870.9 mg/kg (647.1-1094.8, 95% confidence interval). Whereas, LD50 in rats after intraperitoneal injection was determined to be 57.5 mg/kg (45.6-69.4, 95% confidence intervals) and after oral ingestion was 794.3 mg/kg (469.8-1118.8, 95% confidence intervals). The LD50 values presented here after intraperitoneal injection and oral gavages are 10-15 times and 100-150 times greater than doses of thymoquinone reported for its anti-inflammatory, anti-oxidant and anti-cancer effects.


CONCLUSION
Thymoquinone is a relatively safe compound, particularly when given orally to experimental animals.
Paraoxonase 2 (PON2) in the mouse central nervous system: a neuroprotective role?

The aims of this study were to characterize the expression of paraoxonase 2 (PON2) in mouse brain and to assess its antioxidant properties. PON2 levels were highest in the lung, intestine, heart and liver, and lower in the brain; in all tissues, PON2 expression was higher in female than in male mice. PON2 knockout [PON2(-/-)] mice did not express any PON2, as expected. In the brain, the highest levels of PON2 were found in the substantia nigra, the nucleus accumbens and the striatum, with lower levels in the cerebral cortex, hippocampus, cerebellum and brainstem. A similar regional distribution of PON2 activity (measured by dihydrocoumarin hydrolysis) was also found. PON3 was not detected in any brain area, while PON1 was expressed at very low levels, and did not show any regional difference. PON2 levels were higher in astrocytes than in neurons isolated from all brain regions, and were highest in cells from the striatum. PON2 activity and mRNA levels followed a similar pattern. Brain PON2 levels were highest around birth, and gradually declined. Subcellular distribution experiments indicated that PON2 is primarily expressed in microsomes and in mitochondria. The toxicity in neurons and astrocytes of agents known to cause oxidative stress (DMNQ and H(2)O(2)) was higher in cells from PON2(-/-) mice than in the same cells from wild-type mice, despite similar glutathione levels. These results indicate that PON2 is expressed in the brain, and that higher levels are found in dopaminergic regions such as the striatum, suggesting that this enzyme may provide protection against oxidative stress-mediated neurotoxicity.
Haloperidol disrupts opioid-antinociceptive tolerance and physical dependence.

Previous studies from our laboratory and others have implicated a critical role of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in opioid tolerance and dependence. Translational research targeting the CaMKII pathway is challenging, if not impossible, because of a lack of selective inhibitors. We discovered in a preliminary study that haloperidol, a butyrophenone antipsychotic drug, inhibited CaMKII, which led us to hypothesize that haloperidol can attenuate opioid tolerance and dependence by inhibiting CaMKII. The hypothesis was tested in two rodent models of opioid tolerance and dependence. Pretreatment with haloperidol (0.2-1.0 mg/kg i.p.) prevented the development of morphine tolerance and dependence in a dose-dependent manner. Short-term treatment with haloperidol (0.06-0.60 mg/kg i.p.) dose-dependently reversed the established morphine-antinociceptive tolerance and physical dependence. Correlating with behavioral effects, pretreatment or short-term treatment with haloperidol dose-dependently inhibited morphine-induced up-regulation of supraspinal and spinal CaMKIIα activity. Moreover, haloperidol given orally was also effective in attenuating morphine-induced CaMKIIα activity, antinociceptive tolerance, and physical dependence. Taken together, these data suggest that haloperidol attenuates opioid tolerance and dependence by suppressing CaMKII activity. Because haloperidol is a clinically used drug that can be taken orally, we propose that the drug may be of use in attenuating opioid tolerance and dependence.
Image Enhancement Method for Fingerprint Recognition System

Image enhancement plays an important role in fingerprint recognition system. In this paper fingerprint image enhancement method, a refined Gabor filter, is presented. This enhancement method can connect the ridge breaks, ensures the maximal gray values located at the ridge center and has the ability to compensate for the nonlinear deformations. The result shows it can improve the performance of image enhancement
Human tooth wear in the past and the present: tribological mechanisms, scoring systems, dental and skeletal compensations.

This review of human tooth wear describes the fundamental mechanisms underlying this process. Using the tribological approach they can be systematised and this in turn aids our understanding of them. In past populations wear was ubiquitous, intense, abrasive and physiological as it was related to their food and their technologies. In these populations, it affected the proximal surfaces, and the occlusal surfaces which modified the occlusal plane profoundly. To categorise this wear many different classification systems are used, from which we can determine diet, cultural changes and the age at death of individuals. They also illustrate the evolution of certain functional dental and skeletal compensations in the masticatory apparatus such as continuous dental eruption, mesial drift of the arches and incisor lingual tipping which can then be monitored. These physiological adaptations related mainly to function and ontogenesis can also be found in present-day populations where wear is moderate, although they are much less obtrusive. Apart from certain pathological cases associated with a specific parafunction, iatrogenic tooth brushing or an eating disorder and encouraged by an acid environment, they are the result of a physiological process that should not be halted. To ensure this, it is essential to prevent lesions related to tooth wear, to detect them early and establish a reliable diagnosis. Types of tooth wear that had remained unchanged since the origin of humanity have undergone profound changes in a very short space of time. Today's tribochemical pathological model has replaced the abrasive physiological model of the past.
Prevalence of methicillin-resistant Staphylococcus aureus in poultry meat in Qena, Egypt.

Aim: To study the prevalence of pathogenic coagulase positive, methicillin-resistant Staphylococcus aureus (MRSA) in poultry meat and its products. Materials and Methods: A total of 125 poultry samples were collected during 2012 in Qena governorate for presence of pathogenic coagulase positive, methicillin-resistant staphylococcus aureus (MRSA). Samples were taken from freshly slaughtered whole chicken carcasses (25/125), chicken portions (25/125), chicken luncheon (25/125), chicken sausages (25/125) and chicken burgers (25/125). Results: It was observed that 44% (11/25), 52% (13/25), 40% (10/25), 24% (6/25) and 44% (11/25) of bacterial isolates were positive for methicillin-resistance tests for freshly slaughtered whole chicken carcasses, chicken portions, chicken luncheon, chicken sausages and chicken burgers respectively. Higher contamination rate of MRSA was found in raw poultry meat and the lower rate in poultry meat products subjected to heat treatment and preservatives. Conclusion: Poultry meat and its products were considered as an important source of spreading of MRSA in humans. Hence, strict hygienic measures should be taken in poultry slaughter houses and in food preparing establishments.
Cancer genes and the pathways they control

The revolution in cancer research can be summed up in a single sentence: cancer is, in essence, a genetic disease. In the last decade, many important genes responsible for the genesis of various cancers have been discovered, their mutations precisely identified, and the pathways through which they act characterized. The purposes of this review are to highlight examples of progress in these areas, indicate where knowledge is scarce and point out fertile grounds for future investigation.
Combination of Diane-35 and Metformin to Treat Early Endometrial Carcinoma in PCOS Women with Insulin Resistance

BACKGROUND
Young women with polycystic ovary syndrome (PCOS) have a high risk of developing endometrial carcinoma. There is a need for the development of new medical therapies that can reduce the need for surgical intervention so as to preserve the fertility of these patients. The aim of the study was to describe and discuss cases of PCOS and insulin resistance (IR) women with early endometrial carcinoma while being co-treated with Diane-35 and metformin.


METHODS
Five PCOS-IR women who were scheduled for diagnosis and therapy for early endometrial carcinoma were recruited. The hospital records and endometrial pathology reports were reviewed. All patients were co-treated with Diane-35 and metformin for 6 months to reverse the endometrial carcinoma and preserve their fertility. Before, during, and after treatment, endometrial biopsies and blood samples were obtained and oral glucose tolerance tests were performed. Endometrial pathology was evaluated. Body weight (BW), body mass index (BMI), follicle-stimulating hormone (FSH), luteinizing hormone (LH), total testosterone (TT), sex hormone-binding globulin (SHBG), free androgen index (FAI), insulin area under curve (IAUC), and homeostasis model assessment of insulin resistance (HOMA-IR) were determined.


RESULTS
Clinical stage 1a, low grade endometrial carcinoma was confirmed before treatment. After 6 months of co-treatment, all patients showed normal epithelia. No evidence of atypical hyperplasia or endometrial carcinoma was found. Co-treatment resulted in significant decreases in BW, BMI, TT, FAI, IAUC, and HOMA-IR in parallel with a significant increase in SHBG. There were no differences in the FSH and LH levels after co-treatment.


CONCLUSIONS
Combined treatment with Diane-35 and metformin has the potential to revert the endometrial carcinoma into normal endometrial cells in PCOS-IR women. The cellular and molecular mechanisms behind this effect merit further investigation.
14. CONSTRUCTIVIST ISSUES IN LANGUAGE LEARNING AND TEACHING

Constructivism has emerged in recent years as a dominant paradigm in education and has had a major intellectual impact on the development of pedagogy, especially in mathematics and science. Rooted in the cognitive developmental theory of Piaget and in the sociocultural theory of Vygotsky, constructivist notions have had an impact on the development and application of technologically enhanced microworlds and on linguistic investigation into literacy and narrative development. To date, constructivism has had little impact on language pedagogy; however, the advent of content-based pedagogical paradigms as an anchor of language education has opened new opportunities for integration of interdisciplinary collaborative approaches for language teaching and learning. Furthermore, the current emphasis on standardsbased accreditation and reconceptualization of teacher education programs will likely expand the horizons of language pedagogy, bringing constructivist approaches to the foreground in language teacher education and opening new avenues for linguistic and interdisciplinary classroom-based research.
Low physical activity levels and functional decline in individuals with lung cancer.

OBJECTIVES
Physical activity has been infrequently measured objectively in non-small cell lung cancer (NSCLC). We aimed to investigate levels of physical activity, functional and patient reported outcomes at diagnosis and over six months in participants with recently diagnosed NSCLC and compare results with both physical activity guidelines and outcomes of similar-aged healthy individuals.


METHODS
This prospective observational study assessed 50 individuals from three Australian tertiary hospitals with stage I-IIIB NSCLC at diagnosis, then 10 weeks and six months later. Thirty five healthy individuals without cancer were assessed once. Outcome measures included tri-axial accelerometery (number of steps per day), six minute walk distance (6MWD), muscle strength and questionnaires including health-related quality of life (HRQoL).


RESULTS
Individuals with NSCLC were engaged in significantly less physical activity than similar-aged healthy individuals, with 60% not meeting physical activity guidelines. At diagnosis they had worse quadriceps strength, nutritional status and HRQoL. Over six months, participants with NSCLC experienced decline in self-reported physical activity, 6MWD and muscle strength, and worsening symptoms.


CONCLUSION
At diagnosis individuals with NSCLC engage in less physical activity, are weaker and more depressed than healthy individuals and their self-reported physical activity declines over six months. Future studies are required to investigate the efficacy of interventions to increase physical activity.
A minutia-based partial fingerprint recognition system

Matching incomplete or partial fingerprints continues to be an important challenge today, despite the advances made in fingerprint identification techniques. While the introduction of compact silicon chip-based sensors that capture only part of the fingerprint has made this problem important from a commercial perspective, there is also considerable interest in processing partial and latent fingerprints obtained at crime scenes. When the partial print does not include structures such as core and delta, common matching methods based on alignment of singular structures fail. We present an approach that uses localized secondary features derived from relative minutiae information. A flow network-based matching technique is introduced to obtain one-to-one correspondence of secondary features. Our method balances the tradeoffs between maximizing the number of matches and minimizing total feature distance between query and reference fingerprints. A two-hidden-layer fully connected neural network is trained to generate the final similarity score based on minutiae matched in the overlapping areas. Since the minutia-based fingerprint representation is an ANSI-NIST standard [American National Standards Institute, New York, 1993], our approach has the advantage of being directly applicable to existing databases. We present results of testing on FVC2002’s DB1 and DB2 databases. 2005 Pattern Recognition Society. Published by Elsevier Ltd. All rights reserved.
Aberration control and vision training as an effective means of improving accommodation in individuals with myopia.

PURPOSE
To test the efficacy of a novel dual treatment for improving accommodative accuracy and dynamics in young persons with myopia.


METHODS
Ninety-three young persons with myopia (mean spherical equivalent, -3.0 +/- 1.8 D; age 16.8 +/- 2.1 years; spherical aberration +0.06 +/- 0.04 microm) participated in the study. Custom-designed soft contact lenses were used to alter ocular SA to -0.10 microm to improve accommodative accuracy and reduce any lag of accommodation. A vision training regimen was performed for 18 minutes per day for up to 6 weeks to improve speed of dynamic accommodation. Control groups had contact lenses with no added SA and/or no exercises. To avoid any effects of natural levels of negative aberration on the results of the study, all participants who had negative SA were excluded.


RESULTS
The treatment contact lenses produced a significant reduction in lag of accommodation (P < 0.05) at all proximal viewing distances measured. The vision training measurement and treatment resulted in a significant increase in distance facility rate for all groups compared with their own baselines (P < 0.05). Near facility rate improved in the vision training treatment group only compared with its baseline (P < 0.05). Both positive and negative response times for distant viewing were significantly shorter in all groups after training compared with their baseline values (P < 0.05). At near, the positive response times were decreased significantly (P < 0.05) in both groups, whereas the negative response times decreased significantly only in the vision training treatment group.


CONCLUSIONS
After 3 months, the dual treatments (altering SA and vision training) used in the study were effective in modifying accommodation. The static accommodative response to targets at proximal distances was increased by the altered SA contact lenses and rates of dynamic accommodation improved with vision training.