LLukas22/scidocs huggingface dataset:
POSTURAL CHANGES IN BLOOD PRESSURE ASSOCIATED WITH AGEING

The present study reveals to determine the patterns of orthostatic blood pressure (OBP) changes, symptoms and clinical factors in different aged groups. Sixty subjects of different aged group between 20 and 90 were used in this study. Among these groups, different measurements of BP were done in lying as well as standing position at two time intervals (1min, 3min) to check their orthostatic hypotension (OH). The Results showed that OH significantly increased in the age group 71.1 and moderate in 39.8 and no changes occurred in 20.55. The symptoms of head ache, blurred vision, falling and light headedness as well as blood hemoglobin levels were independent of OH in all aged groups. Based on the nutritional status, Body Mass Index was measured in these subjects and identified as 72% well nourished; 4% under-nourished and 24% overweight. The systolic OH (P<0.01) was more common among the elderly subject than diastolic OH (P>0.05). Also prevalence was similar in either gender of elderly group. Based on the present study, we conclude that OH incidence increases with increase in age and symptoms are independent of physical recording.
Mechatronic systems — Innovative products with embedded control

Many technical processes and products in the area of mechanical and electrical engineering are showing an increasing integration of mechanics with digital electronics and information processing. This integration is between the components (hardware) and the information-driven functions (software), resulting in integrated systems called mechatronic systems. Their development involves finding an optimal balance between the basic mechanical structure, sensor and actuator implementation, automatic information processing and overall control. Simultaneous design of mechanics and electronics, hardware and software and embedded control functions resulting in an integrated component or system are all of major importance. This technical progress has a very large influence on a multitude of products in the area of mechanical, electrical and electronic engineering and changes the design, for example, of conventional electromechanical components, machines, vehicles and precision mechanical devices with increasing intensity. This contribution summarizes ongoing developments for mechatronic systems, shows design approaches and examples of mechatronic products and considers various embedded control functions and system’s integrity. One field of ongoing developments, automotive mechatronics, where especially large influences can be seen, is described in more detail by discussing mechatronic suspensions, mechatronic brakes, active steering and roll stabilization systems. r 2007 Published by Elsevier Ltd.
A longitudinal study of the use of mental health services by persons with serious mental illness: do Spanish-speaking Latinos differ from English-speaking Latinos and Caucasians?

OBJECTIVE
Reports of mental health care use by Latinos compared to Caucasians have been mixed. To the authors' knowledge, no large-scale studies have examined the effects of language on mental health service use for Latinos who prefer Spanish compared to Latinos who prefer English and to Caucasians. Language is the most frequently used proxy measure of acculturation. The authors used the administrative database of a mental health system to conduct a longitudinal examination of mental health service use among Spanish-speaking versus English-speaking Latinos and Caucasians with serious mental illness.


METHOD
There were 539 Spanish-speaking Latinos, 1,144 English-speaking Latinos, and 4,638 Caucasians initiating treatment for schizophrenia, bipolar disorder, or major depression during 2001-2004. Using multivariate regressions, the authors examined the differences among the groups in the type of service first used. The authors also examined the probability of use of each of four types of mental health services and the intensity of outpatient treatment.


RESULTS
Spanish-speaking Latinos differed from both English-speaking Latinos and Caucasians on most measures. Compared to patients in the other groups, the Spanish-speaking Latinos were less likely to enter care through emergency or jail services and more likely to enter care through outpatient services. There were no group differences in the proportion that stayed in treatment or used inpatient hospitalization.


CONCLUSIONS
This study suggests that for Latinos, preferred language may be more important than ethnicity in mental health service use. Future studies comparing mental health use may need to differentiate between Spanish- and English-speaking Latinos.
The incretin hormone GLP-1 and mechanisms underlying its secretion.

Glucagon-like peptide-1 (GLP-1) is a cell type-specific post-translational product of proglucagon. It is encoded by the proglucagon gene and released primarily from intestinal endocrine L-cells in response to hormonal, neuronal, and nutritional stimuli. In addition to serving as an incretin in mediating the effect of meal consumption on insulin secretion, GLP-1 exerts other functions in pancreatic islets, including regulation of β-cell proliferation and protection of β-cells against metabolic stresses. Furthermore, GLP-1 exerts numerous other functions in extrapancreatic organs, whereas brain GLP-1 signaling controls satiety. Herein we review the discovery of two incretins and the development of GLP-1-based drugs. We also describe the development of cellular models for studying mechanisms underlying GLP-1 secretion over the past 30 years. However, the main content of this review is a summary of studies on the exploration of mechanisms underlying GLP-1 secretion. We not only summarize studies conducted over the past three decades on elucidating the role of nutritional components and hormonal factors in regulating GLP-1 secretion, but also present a few very recent studies showing the possible role of dietary polyphenols. Finally, the emerging role of gut microbiota in metabolic homeostasis with the potential implication on GLP-1 secretion is discussed.
Effects of aminophyllinein preventing renal failure in premature neonates with asphyxia in Isfahan-Iran.

OBJECTIVES
Considering the relation between prematurity andasphyxia and also renal failure in neonates, the aim of this study was to determine the effect of aminophyllinein urine and serum indices of renal failure and consequently its prevention, in Premature Infants with asphyxia in Esfahan-lran.


METHODS
In this descriptive clinical trial study, 22 preterm neonates diagnosed with perinatal asphyxia in neonatal ward of Shahid Beheshti hospital, during 2009.The participants were randomized in two intervention and placebo groups. They randomized to receive a single dose of aminophyiline (5 mg/kg) or placebo of 5% dextrose water for injection (5 cc/kg) during the first hour of life. Renal function was assessed by GFR, beta2-microglobulin (beta2M), N-acetyl-glucosaminidase (NAG) serum creatinine and electrolytes level measurement, during the 1st, 4th and 7th day of life, in two studied groups. The results compare between the two groups before and after intervention.


RESULTS
Mean of urine output, was significantly higher in neonates who received aminophylline (P < 0.05).Mean of 132M and NAG 24 hours after intervention was not significant in the two groups of asphyxiated preterm neonates (P > 0.05).GFR was significantly higher in neonates who received aminophylline on 4th day of life (P < 0.05) and it had trend to be significantly high on 7th day (P = 0.05) and was not significantly high on 1st day (P > 0.05) comparing with control group. The most common pathophysiology of renal failure was prerenal.


CONCLUSION
Aminophylline could prevent renal dysfunction in preterm neonates with asphyxia. Neonates who received aminophylin on the first day of life indicated a significant improvement in GFR and urine output.
Aspects of Gravitational Clustering

Several issues related to the gravitational clustering of collision-less dark matter in an expanding universe is discussed. The discussion is pedagogical but the emphasis is on semianalytic methods and open questions — rather than on well established results.
Negative Hyper-resolution as Procedural Semantics of Disjunctive Logic Programs

We prove that negative hyper-resolution is a sound and complete procedure for answering queries in disjunctive logic programs. In our formulation, answers of queries are defined using disjunctive substitutions, which are more flexible than answer literals used in theorem proving systems.
The mandibular marginal ramus of the facial nerve: an anatomic and clinical study

Injury to the mandibular marginal ramus of the facial n. constitutes a risk in cervicofacial surgery. The aims of this study were to define the origin of this nerve branch and its course and relations, especially with the lower border of the mandible and the facial vessels. Our observations revealed differences from the classical description of a single nerve branch traveling on the outer aspect of the body of the mandible above its lower border. We found several marginal branches, which become closely related to the facial pedicle, particularly the intermediate ramus, which can form a neural plexus around the facial a. They may follow a submandibular course, before but also after crossing the facial vessels. They are difficult to classify because of their great variability. Une lésion du rameau marginal de la mandibule (Ramus marginalis nervus facialis) représente un risque de la chirurgie cervico-faciale. Les buts de cette étude étaient de préciser l'origine du rameau marginal de la mandibule, son trajet et ses rapports plus particulièrement avec le bord inférieur de la mandibule et les vaisseaux faciaux. Nos observations présentent des divergences avec la description classique d'un rameau nerveux unique cheminant à la face latérale du corps de la mandibule au dessus de son bord inférieur. Nous avons toujours retrouvé plusieurs rameaux marginaux. Ces rameaux entrent en rapport étroit avec le pédicule facial. En particulier le rameau intermédiaire peut réaliser un plexus nerveux autour de l'a. faciale. Ils peuvent adopter un trajet submandibulaire, avant mais aussi après le croisement des vaisseaux faciaux. Leur systématisation est délicate du fait de leur extrême variabilité.
The Spatial Semantic Hierarchy

The Spatial Semantic Hierarchy is a model of knowledge of large-scale space consisting of multiple interacting representations, both qualitative and quantitative. The SSH is inspired by the properties of the human cognitive map, and is intended to serve both as a model of the human cognitive map and as a method for robot exploration and map-building. The multiple levels of the SSH express states of partial knowledge, and thus enable the human or robotic agent to deal robustly with uncertainty during both learning and problem-solving. The control level represents useful patterns of sensorimotor interaction with the world in the form of trajectory-following and hill-climbing control laws leading to locally distinctive states. Local geometric maps in local frames of reference can be constructed at the control level to serve as observers for control laws in particular neighborhoods. The causal level abstracts continuous behavior among distinctive states into a discrete model consisting of states linked by actions. The topological level introduces the external ontology of places, paths and regions by abduction to explain the observed pattern of states and actions at the causal level. Quantitative knowledge at the control, causal and topological levels supports a “patchwork map” of local geometric frames of reference linked by causal and topological connections. The patchwork map can be merged into a single global frame of reference at the metrical level when sufficient information and computational resources are available. We describe the assumptions and guarantees behind the generality of the SSH across environments and sensorimotor systems. Evidence is presented from several partial implementations of the SSH on simulated and physical robots.  2000 Elsevier Science B.V. All rights reserved.
Understanding inverse document frequency: on theoretical arguments for IDF

The term weighting function known as IDF was proposed in 1972, and has since been extremely widely used, usually as part of a TF*IDF function. It is often described as a heuristic, and many papers have been written (some based on Shannon’s Information Theory) seeking to establish some theoretical basis for it. Some of these attempts are reviewed, and it is shown that the Information Theory approaches are problematic, but that there are good theoretical justifications of both IDF and TF*IDF in traditional probabilistic model of information retrieval. Reprinted from: Journal of Documentation 60 no. 5, pp 503–520
An improved method for micropropagation and regeneration of date palm (Phoenix dactylifera L.)

We developed a novel large-scale micropropagation pathway for date palm (Phoenix dactylifera L.) based on organogenesis. We obtained organogenic stems from shoot tip explants of the Moroccan date palm cultivar Najda, and investigated shoot proliferation from these organogenic stems in vitro on various media; Beauchesne medium (BM) and Murashige and Skoog medium (MS) at full-strength, half-strength, and one-third-strength, containing various concentrations (0, 0.25, 0.5, and 1 mg/L) of 2-naphthoxyacetic acid (NOAA) and kinetin. The optimal medium during the multiplication phase was half-strength Murashige and Skoog medium (MS/2) supplemented with 0.5 mg/L NOAA and 0.5 mg/L kinetin (23.5 morphologically superior shoots per explant, with low vitrification rates). For the shoot elongation phase, shoots were transferred to the same proliferation medium, or to MS or MS/2 media without plant growth regulators (PGRs). Shoots elongated rapidly and showed a high rate of root formation on media supplemented with PGRs. For example, on MS/2 medium containing 1 mg/L NOAA and 1 mg/L kinetin, the average shoot length was 15.1 cm, the average number of roots per shoot was 6.2, and their average length was 3.4 cm. On PGR-free media, shoots were shorter with wider and greener leaves, and had fewer roots. The plantlets were transferred to a greenhouse for acclimation. The survival rate after 2 months was related to the medium used during the elongation phase; >90 % of shoots that were cultured on PGR-free media survived, while there was a poor survival rate of shoots that had been cultured on media containing PGRs.
Outcomes and health-related quality of life following hospitalization for an acute exacerbation of COPD.

OBJECTIVE
The purpose of this study was to understand the outcomes for patients admitted to hospital for an acute exacerbation of COPD, and to determine the factors influencing quality of life and health service utilization of patients with COPD.


METHODOLOGY
Hospital outcomes of 282 patients with moderate and severe COPD, for an acute exacerbation, were retrospectively evaluated. After 24 months of follow up, health-related quality of life (QoL) and health service utilization (emergency room (ER) visit and readmission) in 54 patients admitted previously, were surveyed by questionnaires.


RESULTS
Of 282 COPD patients admitted for an acute exacerbation, 28 patients (9.9%) died during hospitalization, 241 patients (85.5%) were discharged home, and only 13 patients (4.6%) needed long-term care facilities. Although over 50% of the patients had survived over 2 years after discharge, their QoL was poor. Patients who frequently went to the ER or were admitted, were those with poor QoL, severe dyspnoea and frequent exacerbation. COPD exacerbation and dyspnoea were the main factors influencing QoL of the patients. Age, comorbidity, QoL, FEV1, frequency of COPD exacerbation, long-term oxygen therapy, and family doctor were the factors determining the likelihood of patients visiting the ER. Frequency of COPD exacerbation, family doctor and living alone were the factors determining which patients were likely to be admitted to hospital.


CONCLUSION
The outcomes and QoL of patients admitted for an acute exacerbation of COPD were poor. The major factors influencing QoL were frequency of COPD exacerbation and severity of dyspnoea. Improvement of social and medical networks (e.g. reducing the number of patients living alone and providing family doctors for patients) may reduce health care service utilization.
Adherence to guideline-recommended therapies among patients with diverse manifestations of vascular disease

BACKGROUND
Current guidelines recommend aspirin, statins, angiotensin-converting enzyme inhibitors (ACEIs), and smoking abstinence for all patients with vascular disease. There is little data on the variation in adherence to guideline-recommended therapies among patients with different clinical manifestations of vascular disease.


PURPOSE
To analyze the variation in adherence to guideline-recommended therapies among patients with diverse manifestations of vascular disease.


METHODS
We analyzed a comprehensive database of all patients with critical limb ischemia, claudication, acute limb ischemia, carotid artery stenosis, subclavian artery stenosis, renal artery stenosis, or mesenteric ischemia who underwent angiography between 2006 and 2013 at a multidisciplinary vascular center.


RESULTS
Among 1,114 patients with vascular disease, adherence to guideline-recommended therapy at time of angiography included use of aspirin in 936 (84%), statins in 753 (68%), ACEIs in 673 (60%), and smoking abstinence in 788 (71%). A total of 335 (30%) patients utilized all four guideline-recommended therapies. Adherence to four guideline-recommended therapies was lowest among patients with acute limb ischemia (14%) and highest among patients with renal artery stenosis (37%). Among all patients with vascular disease, the range of adherence to individual guidelines was 64%-91% for aspirin, 43%-83% for statins, 49%-66% for ACEIs, and 47%-78% for smoking abstention.


CONCLUSION
The majority of patients with diverse manifestations of vascular disease take aspirin and abstain from smoking while fewer patients are prescribed ACEIs and statins. Among the current recommendations, statins have the widest variation in adherence. Less than one-third of patients with diverse manifestations of vascular disease are prescribed all four guideline-recommended therapies.
L1000CDS2: LINCS L1000 characteristic direction signatures search engine

The library of integrated network-based cellular signatures (LINCS) L1000 data set currently comprises of over a million gene expression profiles of chemically perturbed human cell lines. Through unique several intrinsic and extrinsic benchmarking schemes, we demonstrate that processing the L1000 data with the characteristic direction (CD) method significantly improves signal to noise compared with the MODZ method currently used to compute L1000 signatures. The CD processed L1000 signatures are served through a state-of-the-art web-based search engine application called L1000CDS2. The L1000CDS2 search engine provides prioritization of thousands of small-molecule signatures, and their pairwise combinations, predicted to either mimic or reverse an input gene expression signature using two methods. The L1000CDS2 search engine also predicts drug targets for all the small molecules profiled by the L1000 assay that we processed. Targets are predicted by computing the cosine similarity between the L1000 small-molecule signatures and a large collection of signatures extracted from the gene expression omnibus (GEO) for single-gene perturbations in mammalian cells. We applied L1000CDS2 to prioritize small molecules that are predicted to reverse expression in 670 disease signatures also extracted from GEO, and prioritized small molecules that can mimic expression of 22 endogenous ligand signatures profiled by the L1000 assay. As a case study, to further demonstrate the utility of L1000CDS2, we collected expression signatures from human cells infected with Ebola virus at 30, 60 and 120 min. Querying these signatures with L1000CDS2 we identified kenpaullone, a GSK3B/CDK2 inhibitor that we show, in subsequent experiments, has a dose-dependent efficacy in inhibiting Ebola infection in vitro without causing cellular toxicity in human cell lines. In summary, the L1000CDS2 tool can be applied in many biological and biomedical settings, while improving the extraction of knowledge from the LINCS L1000 resource.
Analysis of a linear series-fed rectangular microstrip antenna array

A new method is proposed to analyze a linear series-fed microstrip antenna array which maintains accuracy while not requiring a full-wave analysis of the entire structure. The method accounts for mutual coupling between patches as well as the patch excitations by the feed lines.
What Role for Public Participation in Implementing the EU Floods Directive? A comparison with the Water Framework Directive, early evidence from Germany, and a research agenda

We examine the roles and functions of non-state actor participation in implementing the EU Floods Directive of 2007 (FD). We draw on experiences with participation under the Water Framework Directive (WFD), because of important links between the two directives. Comparing the legal basis and the different functions for participation, we observe the paradoxical situation that while the WFD has fervently advocated public participation, public interest has remained low, whereas the FD is less sanguine about participation, despite citizens being potentially more affected by flood management issues – particularly given the current trend towards a ‘risk management’ approach under the FD. Our examination of current FD implementation in Germany reveals a considerable variety of participation approaches, as well as a general trend to ‘less’ rather than ‘more’ participation as compared to the WFD. The paper closes by discussing implications for future flood management planning and avenues for comparative research.
Lifestyle modification for resistant hypertension: The TRIUMPH randomized clinical trial.

BACKGROUND
Resistant hypertension (RH) is a growing health burden in this country affecting as many as 1 in 5 adults being treated for hypertension. Resistant hypertension is associated with increased risk of adverse cardiovascular disease (CVD) events and all-cause mortality. Strategies to reduce blood pressure (BP) in this high-risk population are a national priority.


METHODS
TRIUMPH is a single-site, prospective, randomized clinical trial to evaluate the efficacy of a center-based lifestyle intervention consisting of exercise training, reduced sodium and calorie Dietary Approaches to Stop Hypertension eating plan, and weight management compared to standardized education and physician advice in treating patients with RH. Patients (n = 150) will be randomized in a 2:1 ratio to receive either a 4-month supervised lifestyle intervention delivered in the setting of a cardiac rehabilitation center or to a standardized behavioral counseling session to simulate real-world medical practice. The primary end point is clinic BP; secondary end points include ambulatory BP and an array of CVD biomarkers including left ventricular hypertrophy, arterial stiffness, baroreceptor reflex sensitivity, insulin resistance, lipids, sympathetic nervous system activity, and inflammatory markers. Lifestyle habits, BP, and CVD risk factors also will be measured at 1-year follow-up.


CONCLUSIONS
The TRIUMPH randomized clinical trial (ClinicalTrials.gov NCT02342808) is designed to test the efficacy of an intensive, center-based lifestyle intervention compared to a standardized education and physician advice counseling session on BP and CVD biomarkers in patients with RH after 4 months of treatment and will determine whether lifestyle changes can be maintained for a year.