LLukas22/scidocs huggingface dataset:
Vaginal labiaplasty: current practices and a simplified classification system for labial protrusion.

BACKGROUND
Vaginal labiaplasty has been described for the management of functional and aesthetic problems associated with protrusion of the labia minora. Despite increasing numbers of procedures performed, there is a paucity of data to guide treatment paradigms. This systematic review aims to establish a simple, unifying classification scheme for labial protrusion and summarize current labiaplasty techniques and practices.


METHODS
A systematic literature review was performed using the PubMed database. Additional articles were selected after reviewing references of identified articles.


RESULTS
The search returned 247 articles. After applying inclusion criteria to identify prospective and retrospective studies evaluating different techniques, outcomes, complications, and patient satisfaction, 19 articles were selected. Labiaplasty of the labia minora was described in 1949 patients. Seven different surgical techniques were used for labiaplasty, including deepithelialization, direct excision, W-shaped resection, wedge resection, composite reduction, Z-plasty, and laser excision. Patient satisfaction rates for each technique ranged from 94 to 100 percent. The most common postoperative complication for all techniques was wound dehiscence (4.7 percent). Key areas for perioperative patient management were defined.


CONCLUSIONS
Labiaplasty is safe and carries a high satisfaction rate. However, current practices remain exceedingly diverse. The authors propose a simplified classification system based on the distance of the lateral edge of the labia minora from that of the labia majora, rather than from the introitus. Key areas for perioperative patient management include patient anesthesia, resection technique used, wound closure, and postoperative care. Further randomized studies using a standardized classification system are required to better compare different techniques and establish best practices.
Security Concerns in Popular Cloud Storage Services

The authors provide a systematic security analysis on the sharing methods of three major cloud storage and synchronization services: Dropbox, Google Drive, and Microsoft SkyDrive. They show that all three services have security weaknesses that may result in data leakage without users' awareness.
Essence, Reflexion, and Immediacy in Hegel's Science of Logic

This companion provides original, scholarly, and cutting-edge essays that cover the whole range of Hegel's mature thought and his lasting influence. * A comprehensive guide to one of the most important modern philosophers * Essays are written in an accessible manner and draw on the most up-to-date Hegel research * Contributions are drawn from across the world and from a wide variety of philosophical approaches and traditions * Examines Hegel's influence on a range of thinkers, from Kierkegaard and Marx to Heidegger, Adorno and Derrida * Begins with a chronology of Hegel's life and work and is then split into sections covering topics such as Philosophy of Nature, Aesthetics, and Philosophy of Religion
Family Business in the Middle East: An Eexploratory Study of Retail Management in Kuwait and Lebanon

The Middle East is a growing, lucrative marketplace that has recently captured the interest of the world for political as well as economic reasons due to the War in Iraq, which began in 2003. This exploratory study examines the relationship between retail small/medium enterprises (SMEs) that are family business owned, organizational commitment, and management and employee perceptions of customer service on a number of dimensions. The results suggest that managers and employees of family-owned businesses in the Middle East behave in ways similar to those in Western countries; however, there are differences, probably related to cultural characteristics. The Middle East is a richly diverse region, a myriad of unique cultures. As the market becomes more sophisticated, the importance of service quality increases. Global retailers can benefit from this study by better understanding the managers and employees in the region and the pivotal role of the family on business. Implications for practice are discussed.
Platelet aggregation in traumatic spinal cord injury

Study design: Collagen-induced platelet aggregation and platelet count of ten paraplegic patients (four females, six males, aged 16–42 years) with traumatic spinal cord injury (SCI) (posttraumatic 12–48 weeks) and of ten age-matched healthy volunteers (control group; five females, five males, aged 18–37 years) were investigated. Objectives: Investigation of platelet aggregation in the whole blood of the patients with SCI. Setting: Ankara/Turkey. Methods: Platelet aggregation was evaluated by impedance technique using Chrono Log Model 560 WB aggregometer in whole blood. Platelet count was determined by Medonic Cell Analyser 610. Results: Maximal intensity of collagen-induced platelet aggregation of the patients was 18.50±8.28 ohm (mean±SD) and of the controls was 7.60±4.25 ohm. Maximal rate of collagen-induced aggregation of platelets from the patients was 3.98±1.59 ohm/min, maximal rate of aggregation of platelets from the controls was 1.57±1.01 ohm/min. Platelet counts of the patients and controls were 290 500±50 357/mm3 and 273 000±48 343/mm3 respectively. It was determined that both maximal rate (P<0.001) and maximal intensity (P<0.01) of collagen-induced platelet aggregation of the patients were significantly higher than those of the controls. There was no significant difference between the two groups in respect to platelet counts. Conclusion: Collagen-induced platelet aggregation of patients with traumatic SCI 12–48 weeks after the trauma was significantly higher than that of the controls. Our results indicate that increased tendency of platelet aggregation, which is probably induced by free radicals, may have a great impact on the late thromboembolic complications reported in patients with traumatic SCI.
A multi-scale convolutional neural network for phenotyping high-content cellular images

Motivation
Identifying phenotypes based on high-content cellular images is challenging. Conventional image analysis pipelines for phenotype identification comprise multiple independent steps, with each step requiring method customization and adjustment of multiple parameters.


Results
Here, we present an approach based on a multi-scale convolutional neural network (M-CNN) that classifies, in a single cohesive step, cellular images into phenotypes by using directly and solely the images' pixel intensity values. The only parameters in the approach are the weights of the neural network, which are automatically optimized based on training images. The approach requires no a priori knowledge or manual customization, and is applicable to single- or multi-channel images displaying single or multiple cells. We evaluated the classification performance of the approach on eight diverse benchmark datasets. The approach yielded overall a higher classification accuracy compared with state-of-the-art results, including those of other deep CNN architectures. In addition to using the network to simply obtain a yes-or-no prediction for a given phenotype, we use the probability outputs calculated by the network to quantitatively describe the phenotypes. This study shows that these probability values correlate with chemical treatment concentrations. This finding validates further our approach and enables chemical treatment potency estimation via CNNs.


Availability and Implementation
The network specifications and solver definitions are provided in Supplementary Software 1.


Contact
william_jose.godinez_navarro@novartis.com or xian-1.zhang@novartis.com.


Supplementary information
Supplementary data are available at Bioinformatics online.
Recursive estimation of emitter location using TDOA measurements from two UAVs

This paper considers the recursive estimation of emitter location using time difference of arrival measurements formed by the correlation of signals received by two unmanned aerial vehicles. The time difference of arrival measurement defines an hyperbola of possible emitter locations. This hyperbola is used as a measurement in a nonlinear Alter. The performance of two such filters, an extended Kalman filter (EKF) and an unscented Kalman filter (UKF), is analysed for a stationary and moving emitter and compared with the Cramer-Rao lower bound. The UKF performs generally better than the EKF, but both algorithms suffer from diverged tracks.
Sustained inhibition of receptor tyrosine kinases and macrophage depletion by PLX3397 and rapamycin as a potential new approach for the treatment of MPNSTs.

PURPOSE
Malignant peripheral nerve sheath tumor (MPNST) is a highly aggressive tumor type that is resistant to chemotherapy and there are no effective therapies. MPNSTs have been shown to have gene amplification for receptor tyrosine kinases (RTK), PDGFR and c-Kit. We tested the c-Kit inhibitor, imatinib, and PLX3397, a selective c-Fms and c-Kit inhibitor, to evaluate their efficacy against MPNST cells in vitro and in vivo.


EXPERIMENTAL DESIGN
We tested the efficacy of imatinib or PLX3397 either alone or in combination with TORC1 inhibitor rapamycin in a cell proliferation assay in vitro and by immunoblotting to determine target inhibition. Immunoblotting and immunohistochemical analysis was further carried out using xenograft samples in vivo.


RESULTS
Our in vitro studies show that imatinib and PLX3397 similarly inhibit cell growth and this can be enhanced with rapamycin with comparable target specificity. However, in vivo studies clearly demonstrate that compared with imatinib, PLX3397 results in sustained blockade of c-Kit, c-Fms, and PDGFRβ, resulting in significant suppression of tumor growth. Moreover, staining for Iba-1, a marker for macrophages, indicates that PLX3397 results in significant depletion of macrophages in the growing tumors. The combination of PLX3397 and rapamycin results in even greater macrophage depletion with continued growth suppression, even when the drug treatment is discontinued.


CONCLUSIONS
Taken together, our data strongly suggest that PLX3397 is superior to imatinib in the treatment of MPNSTs, and the combination of PLX3397 with a TORC1 inhibitor could provide a new therapeutic approach for the treatment of this disease.
The Value of Calcaneal Bone Mass Measurement Using a Dual X-Ray Laser Calscan Device in Risk Screening for Osteoporosis

OBJECTIVE
To evaluate how bone mineral density in the calcaneus measured by a dual energy X-ray laser (DXL) correlates with bone mineral density in the spine and hip in Turkish women over 40 years of age and to determine whether calcaneal dual energy X-ray laser variables are associated with clinical risk factors to the same extent as axial bone mineral density measurements obtained using dual energy x-ray absorbtiometry (DXA).


MATERIALS AND METHODS
A total of 2,884 Turkish women, aged 40-90 years, living in Ankara were randomly selected. Calcaneal bone mineral density was evaluated using a dual energy X-ray laser Calscan device. Subjects exhibiting a calcaneal dual energy X-ray laser T- score < or = -2.5 received a referral for DXA of the spine and hip. Besides dual energy X-ray laser measurements, all subjects were questioned about their medical history and the most relevant risk factors for osteoporosis.


RESULTS
Using a T-score threshold of -2.5, which is recommended by the World Health Organization (WHO), dual energy X-ray laser calcaneal measurements showed that 13% of the subjects had osteoporosis, while another 56% had osteopenia. The mean calcaneal dual energy X-ray laser T-score of postmenopausal subjects who were smokers with a positive history of fracture, hormone replacement therapy (HRT), covered dressing style, lower educational level, no regular exercise habits, and low tea consumption was significantly lower than that obtained for the other group (p<0.05). A significant correlation was observed between the calcaneal dual energy X-ray laser T-score and age (r= -0.465, p=0.001), body mass index (BMI) (r=0.223, p=0.001), number of live births (r= -0.229, p=0.001), breast feeding time (r= -0.064, p=0.001), and age at menarche (r= -0.050, p=0.008). The correlations between calcaneal DXL and DXA T-scores (r=0.340, p=0.001) and calcaneal DXL and DXA Z-scores (r=0.360, p=0.001) at the spine, and calcaneal DXL and DXA T- scores (r=0.28, p=0.001) and calcaneal DXL and DXA Z-scores (r=0.33, p=0.001) at the femoral neck were statistically significant.


CONCLUSION
Bone mineral density measurements in the calcaneus using a dual energy X-ray laser are valuable for screening Turkish women over 40 years of age for the risk of osteoporosis.
Oxidation pre-treatment and electrophoretic deposition of SiC nanowires to improve the thermal shock resistance of SiC coating for C/C composites

Abstract To improve the thermal shock resistance of SiC coating for carbon/carbon composites (C/Cs) prepared by chemical vapor deposition (CVD), mild oxidation of C/C substrate and electrophoretic deposition (EPD) of SiC nanowires were used before CVD, aiming to modify the mechanical properties of SiC coating. In comparison to the pristine one, the modified SiC coating shows 73.1% and 93.5% improvements respectively in fracture toughness and adhesion with C/Cs, which endows the coating with fewer and smaller cracks and better thermal shock resistance between 1200 °C and room temperature. It has been also demonstrated that the combined pre-treatments can increase the thermal shock performance of CVD SiC coating better than individual one, which paves a way for greatly increasing the efficiency of SiC coating in protecting C/Cs against oxidation consumption at intermediate temperatures (800–1200 °C).
Embodying gesture-based multimedia to improve learning

Introduction As revealed by the recent Horizon Report (Johnson, Smith, Willis, Levine & Haywood, 2011), the creation of gesture-based interfaces (eg, Microsoft Kinect, Nintendo Wii and Apple iPhone/iPad) create promising opportunities for educators to offer students easier and more intuitive ways to interact with the content in multimedia learning environments than ever before. For instance, Kinect, a motion-sensing input device developed by Microsoft for Xbox360 (Redmond, WA, USA), enables students to use their body motions, such as swiping, jumping and moving, to interact with the content on the screen. Growing communities (eg, KinectEDucation; http://www. kinecteducation.com/) advocate integrating Kinect applications into classroom teaching to make students’ learning experiences more active and joyful. Few studies investigate the impact of gesture-based multimedia learning on students’ cognitive learning outcomes and/or its theoretical underpinnings. This paper briefly discusses the theoretical underpinnings for adopting gesture-based multimedia learning, then describes how we used Kinect to embody the most common type of multimedia learning in classroom (ie, PowerPoint presentations) and finally details a preliminary study exploring the impact of gesture-based multimedia learning on students’ cognitive learning outcomes.
On the Effectiveness of Defensive Distillation

We report experimental results indicating that defensive distillation successfully mitigates adversarial samples crafted using the fast gradient sign method [2], in addition to those crafted using the Jacobian-based iterative attack [5] on which the defense mechanism was originally evaluated.
Effects of the kappa opioid receptor antagonist, norbinaltorphimine, on stress and drug-induced reinstatement of nicotine-conditioned place preference in mice

Several studies implicate stress as a risk factor for the development and maintenance of drug addictive behaviors and drug relapse. Kappa opioid receptor (KOR) antagonists have been shown to attenuate behavioral responses to stress and stress-induced reinstatement of cocaine and ethanol seeking and preference. In the current study, we determined whether the selective KOR antagonist, norbinaltorphimine (nor-BNI), would block stress-induced reinstatement of nicotine preference. Adult Institute of Cancer Research mice were conditioned with 0.5 mg/kg nicotine, injected subcutaneously (s.c.) for 3 days and tested in the nicotine-conditioned place preference (CPP) model. After 3 days extinction, nor-BNI (10 mg/kg, s.c.) was administered 16 h prior to a priming dose of nicotine (0.1 mg/kg, s.c.), and mice were tested in the CPP model for nicotine-induced reinstatement of CPP. A separate group of mice was subjected to a 2-day modified forced swim test (FST) paradigm to induce stress after 3 days extinction from CPP. Mice were given vehicle or nor-BNI (10 mg/kg, s.c.) 16 h prior to each FST session. Nor-BNI pretreatment significantly attenuated stress-induced reinstatement of nicotine-CPP, but had no effect on nicotine-primed reinstatement. Blockade of KORs by selective antagonists attenuates stress-induced reinstatement of nicotine-CPP. Overall, the kappa opioid system may serve as a therapeutic target for suppressing multiple signaling processes which contribute to maintenance of smoking, smoking relapse, and drug abuse in general.
3D printing for the design and fabrication of polymer-based gradient scaffolds.

To accurately mimic the native tissue environment, tissue engineered scaffolds often need to have a highly controlled and varied display of three-dimensional (3D) architecture and geometrical cues. Additive manufacturing in tissue engineering has made possible the development of complex scaffolds that mimic the native tissue architectures. As such, architectural details that were previously unattainable or irreproducible can now be incorporated in an ordered and organized approach, further advancing the structural and chemical cues delivered to cells interacting with the scaffold. This control over the environment has given engineers the ability to unlock cellular machinery that is highly dependent upon the intricate heterogeneous environment of native tissue. Recent research into the incorporation of physical and chemical gradients within scaffolds indicates that integrating these features improves the function of a tissue engineered construct. This review covers recent advances on techniques to incorporate gradients into polymer scaffolds through additive manufacturing and evaluate the success of these techniques. As covered here, to best replicate different tissue types, one must be cognizant of the vastly different types of manufacturing techniques available to create these gradient scaffolds. We review the various types of additive manufacturing techniques that can be leveraged to fabricate scaffolds with heterogeneous properties and discuss methods to successfully characterize them.


STATEMENT OF SIGNIFICANCE
Additive manufacturing techniques have given tissue engineers the ability to precisely recapitulate the native architecture present within tissue. In addition, these techniques can be leveraged to create scaffolds with both physical and chemical gradients. This work offers insight into several techniques that can be used to generate graded scaffolds, depending on the desired gradient. Furthermore, it outlines methods to determine if the designed gradient was achieved. This review will help to condense the abundance of information that has been published on the creation and characterization of gradient scaffolds and to provide a single review discussing both methods for manufacturing gradient scaffolds and evaluating the establishment of a gradient.
Second-line antiretroviral therapy in resource-limited settings: the experience of Médecins Sans Frontières.

OBJECTIVES
To describe the use of second-line protease-inhibitor regimens in Médecins Sans Frontières HIV programmes, and determine switch rates, clinical outcomes, and factors associated with survival.


DESIGN/METHODS
We used patient data from 62 Médecins Sans Frontières programmes and included all antiretroviral therapy-naive adults (> 15 years) at the start of antiretroviral therapy and switched to a protease inhibitor-containing regimen with at least one nucleoside reverse transcriptase inhibitor change after more than 6 months of nonnucleoside reverse transcriptase inhibitor first-line use. Cumulative switch rates and survival curves were estimated using Kaplan-Meier methods, and mortality predictors were investigated using Poisson regression.


RESULTS
Of 48,338 adults followed on antiretroviral therapy, 370 switched to a second-line regimen after a median of 20 months (switch rate 4.8/1000 person-years). Median CD4 cell count at switch was 99 cells/microl (interquartile ratio 39-200; n = 244). A lopinavir/ritonavir-based regimen was given to 51% of patients and nelfinavir-based regimen to 43%; 29% changed one nucleoside reverse transcriptase inhibitor and 71% changed two nucleoside reverse transcriptase inhibitors. Median follow-up on second-line antiretroviral therapy was 8 months, and probability of remaining in care at 12 months was 0.86. Median CD4 gains were 90 at 6 months and 135 at 12 months. Death rates were higher in patients in World Health Organization stage 4 at antiretroviral therapy initiation and in those with CD4 nadir count less than 50 cells/microl.


CONCLUSION
The rate of switch to second-line treatment in antiretroviral therapy-naive adults on non-nucleoside reverse transcriptase inhibitor-based first-line antiretroviral therapy was relatively low, with good early outcomes observed in protease inhibitor-based second-line regimens. Severe immunosuppression was associated with increased mortality on second-line treatment.
Multifamily psychoeducation for improvement of mental health among relatives of patients with major depressive disorder lasting more than one year: study protocol for a randomized controlled trial

BACKGROUND
Major depressive disorder (MDD) is a long-lasting disorder with frequent relapses that have significant effects on the patient's family. Family psychoeducation is recognized as part of the optimal treatment for patients with psychotic disorder. A previous randomized controlled trial has found that family psychoeducation is effective in enhancing the treatment of MDD. Although MDD can easily become a chronic illness, there has been no intervention study on the families of patients with chronic depression. In the present study, we design a randomized controlled trial to examine the effectiveness of family psychoeducation in improving the mental health of relatives of patients with MDD lasting more than one year.


METHODS/DESIGN
Participants are patients with MDD lasting more than one year and their relatives. Individually randomized, parallel-group trial design will be employed. Participants will be allocated to one of two treatment conditions: relatives will receive (a) family psychoeducation (four, two-hour biweekly multifamily psychoeducation sessions) plus treatment-as-usual for the patient (consultation by physicians), or (b) counseling for the family (one counseling session from a nurse) plus treatment-as-usual for the patient. The primary outcome measure will be relatives' mental health as measured by K6 that was developed to screen for DSM-IV depressive and anxiety disorder. Additionally, the severity of depressive symptoms in patients measured by the Beck Depression Inventory-II (BDI-II) scale will be assessed. Data from the intention-to-treat sample will be analyzed 16 weeks after randomization.


DISCUSSION
This is the first study to evaluate the effectiveness of family psychoeducation for relatives of patients with MDD lasting more than one year. If this type of intervention is effective, it could be a new method of rehabilitation for patients with MDD lasting more than one year.


TRIAL REGISTRATION
Clinical Trials.gov NCT01734291 (registration date: 18 October 2012).