LLukas22/scidocs huggingface dataset:
Factors affecting ¹⁸F FDOPA standardized uptake value in patients with primary brain tumors after treatment.

AIM
To investigate the factors affecting (18)F FDOPA uptake in patients with primary brain tumors (PBT) after treatment.


MATERIALS AND METHODS
97 patients with PBT (6 were grade I, 40 were grade II, 29 were grade III and 22 were grade IV) underwent (18)F FDOPA positron emission tomography/computed tomography (PET/CT) after treatment. Intervals from surgery, chemotherapy (CHT) and radiotherapy (RT) were 41.48 (±42.27), 16.04 (±29.08) and 28.62 (±34.49) months respectively.


RESULTS
(18)F FDOPA uptake in the site of recurrence was not related to the interval from surgery and CHT while a significant relationship has been found with the interval from RT and tumor grade.


CONCLUSIONS
The results of our study show that the interval from RT and the grade of PBT should be considered carefully when evaluating brain PET/CT scans since these factors could directly affect (18)F FDOPA uptake.
Oculomotor responses during partial and total sleep deprivation.

INTRODUCTION
Oculomotor responses related to the pupil light reflex (PLR) and saccadic velocity may be sensitive to the effects of sleepiness and therefore could be used to evaluate an individual's fitness for duty.


METHODS
There were 12 normal subjects who completed an 8-d study. They were allowed 8 h in bed on the first three nights, 4 h in bed on the fourth night, and then were sleep deprived for the following 64 h. Approximately every 3 h, subjects performed a battery of tests which included a 45-s automated oculomotor test and a 40-min PC-based driving simulator task. Sleepiness was evaluated with a self-assessment instrument. Subjects were allowed 10 h of recovery sleep following sleep deprivation.


RESULTS
Oculomotor results for nine subjects showed a significant increase in latency to pupil constriction and a significant decrease in saccadic velocity with total, but not partial, sleep deprivation. The most robust changes during sleep deprivation occurred for saccadic velocity. A night of recovery sleep reversed the effects of total sleep deprivation on latency to pupil constriction and saccadic velocity. Subjective sleepiness and off-road accidents were found to significantly increase over the sleep deprivation period. A significant positive correlation between increasing latency to pupil constriction and increasing sleepiness and driving accidents, and a significant negative correlation between decreasing saccadic velocity and increasing sleepiness and driving accidents during sleep deprivation were found.


CONCLUSION
These findings suggest that oculomotor functions, particularly saccadic velocity, are feasible for assessing neurophysiological changes associated with and predictive of sleep deprivation-induced operational performance degradation.
iCanCope with Pain™: User-centred design of a web- and mobile-based self-management program for youth with chronic pain based on identified health care needs

BACKGROUND
While there are emerging web-based self-management programs for children and adolescents with chronic pain, there is currently not an integrated web- and smartphone-based app that specifically addresses the needs of adolescents with chronic pain.


OBJECTIVES
To conduct a needs assessment to inform the development of an online chronic pain self-management program for adolescents, called iCanCope with Pain™.


METHODS
A purposive sample of adolescents (n=23; 14 to 18 years of age) was recruited from two pediatric chronic pain clinics in Ontario. Interdisciplinary health care providers were also recruited from these sites. Three focus groups were conducted with adolescents (n=16) and one with pediatric health care providers (n=7). Individual adolescent interviews were also conducted (n=7).


RESULTS
Qualitative analysis uncovered four major themes: pain impact; barriers to care; pain management strategies; and transition to adult care. Pain impacted social, emotional, physical and role functioning, as well as future goals. Barriers to care were revealed at the health care system, patient and societal levels. Pain management strategies included support systems, and pharmacological, physical and psychological approaches. Transition subthemes were: disconnect between pediatric and adult systems; skills development; parental role; and fear⁄anxiety. Based on these identified needs, the iCanCope with Pain™ architecture will include the core theory-based functionalities of: symptom self-monitoring; personalized goal setting; pain coping skills training; peer-based social support; and chronic pain education.


CONCLUSIONS
The proposed iCanCope with Pain™ program aims to address the self-management needs of adolescents with chronic pain by improving access to disease information, strategies to manage symptoms and social support.
Intrusion Detection Systems : Technologies, Weaknesses and Trends

Abstract Traditionally, firewalls and access control have been the most important components used in order to secure servers, hosts and computer networks. Today, intrusion detection systems (IDSs) are gaining attention and the usage of these systems is increasing. This thesis covers commercial IDSs and the future direction of these systems. A model and taxonomy for IDSs and the technologies behind intrusion detection is presented. Today, many problems exist that cripple the usage of intrusion detection systems. The decreasing confidence in the alerts generated by IDSs is directly related to serious problems like false positives. By studying IDS technologies and analyzing interviews conducted with security departments at Swedish banks, this thesis identifies the major problems within IDSs today. The identified problems, together with recent IDS research reports published at the RAID 2002 symposium, are used to recommend the future direction of commercial intrusion detection systems. Intrusion Detection Systems – Technologies, Weaknesses and Trends
The UK Functional Assessment Measure (UK FIM+FAM): Psychometric Evaluation in Patients Undergoing Specialist Rehabilitation following a Stroke from the National UK Clinical Dataset

The UK Functional Assessment Measure (UKFIM+FAM) is the principal outcome measure for the UK Rehabilitation Outcomes Collaborative (UKROC) national database for specialist rehabilitation. Previously validated in a mixed neurorehabilitation cohort, this study is the first to explore its psychometric properties in a stroke population, and compare left and right hemispheric strokes (LHS vs RHS). We analysed in-patient episode data from 62 specialist rehabilitation units collated through the UKROC database 2010-2013. Complete data were analysed for 1,539 stroke patients (LHS: 588, RHS: 566 with clear localisation). For factor analysis, admission and discharge data were pooled and randomised into two equivalent samples; the first for exploratory factor analysis (EFA) using principal components analysis, and the second for confirmatory factor analysis (CFA). Responsiveness for each subject (change from admission to discharge) was examined using paired t-tests and differences between LHS and RHS for the entire group were examined using non-paired t-tests. EFA showed a strong general factor accounting for >48% of the total variance. A three-factor solution comprising motor, communication and psychosocial subscales, accounting for >69% total variance, provided acceptable fit statistics on CFA (Root Mean Square Error of Approximation was 0.08 and Comparative Fit Index/ Tucker Lewis Index 0.922/0.907). All three subscales showed significant improvement between admission and discharge (p<0.001) with moderate effect sizes (>0.5). Total scores between LHS and RHS were not significantly different. However, LHS showed significantly higher motor scores (Mean 5.7, 95%CI 2.7, 8.6 p<0.001), while LHS had significantly lower cognitive scores, primarily in the communication domain (-6.8 95%CI -7.7, -5.8 p<0.001). To conclude, the UK FIM+FAM has a three-factor structure in stroke, similar to the general neurorehabilitation population. It is responsive to change during in-patient rehabilitation, and distinguishes between LHS and RHS. This tool extends stroke outcome measurement beyond physical disability to include cognitive, communication and psychosocial function.
Effect of tranexamic acid on melasma: a clinical trial with histological evaluation.

BACKGROUND
Melasma is associated with epidermal hyperpigmentation, weak basement membrane, vascular proliferation and increased numbers of mast cell. Tranexamic acid (TXA), a plasmin inhibitor, is reported to improve melasma when injected locally. However, the effects of oral and topical TXA on melasma have not been well studied and the underlying mechanism remains unclear.


OBJECTIVES
To elucidate the effects of oral and topical TXA on melasma.


METHODS
A clinical study was conducted with 25 women for 8 weeks from March to July 2010. Volunteers were instructed to take two TXA tablets three times a day and apply a TXA topical agent twice a day for 8 weeks. Skin pigmentation and erythema was measured using a Mexameter(®) during each visit and skin biopsies were collected from eight subjects before and 8 weeks after treatment. Fontana-Masson, anti-CD31, antitryptase and antitype IV collagen staining was performed.


RESULTS
Twenty-two subjects completed the study and no serious adverse events occurred during the study period. The mean lesional melanin index (MI) scores decreased significantly. Interestingly, the MI scores for the perilesional skin increased. The erythema index scores of lesional and perilesional skin also showed a similar pattern. Histological analysis showed significant reduction of epidermal pigmentation, vessel numbers and mast cell counts. Type IV collagen staining was not observed in all specimens.


CONCLUSION
TXA decreased epidermal pigmentation associated with melasma and also reversed melasma-related dermal changes, such as vessel number and increased numbers of mast cells.
The conundrum of IT management

This paper presents a robust argument as to why it can be difficult for chief information officers (CIOs) to generate business value from investments that their organizations make in IT with contemporary organizational structures, authority patterns, processes and mindsets. This argument is built on the subtle premise that organizations should not seek to merely manage IT but to manage the delivery of business value through IT. It takes the view that this latter quest is knowledge-based and that the knowledge resources to successfully deliver this value are distributed throughout the organization. Crucially, this knowledge is not located solely within the IT function, presenting a challenge for the CIO for its integration and coordination. With the CIO having little or no jurisdiction over all required knowledge, its deployment will therefore be fragmented. The conundrum of IT management is how to generate value through IT without having access and authority over necessary resources. Research and practitioner implications of this analysis are highlighted.
The Rape of the Masters: How Political Correctness Sabotages Art

Introduction: The Rape of the Masters Psychoanalysing Courbet Inventing Mark Rothko Fantasising Sargent Inebriating Rubens Modernising Winslow Homer Fetishising Gauguin Deconcealing van Gogh Index.
Management of chronic myeloid leukaemia in relapse following donor lymphocyte infusion induced remission: a retrospective study of the clinical trials committee of the British Society of Blood & Marrow Transplantation (BSBMT)

Summary:Donor lymphocyte infusion (DLI) can restore remission in a high percentage of patients with chronic myeloid leukaemia (CML) who relapse after allogeneic stem cell transplant (SCT). Subsequent relapses after a DLI-induced remission do occur and the optimal management of these patients is not defined. A retrospective study of the practice of UK transplant centres was conducted. In all, 13 patients from seven centres were identified: all were treated for relapse post allogeneic SCT with DLI and achieved either a complete cytogenetic (n=5) or molecular (n=8) remission. All patients subsequently had a second relapse, at molecular (n=7), cytogenetic (n=4) and haematological (n=2) levels. Further DLI was used in the treatment of 11 patients, imatinib mesylate in three and chemotherapy in two. The two patients with haematological relapse died of blastic disease. The remaining 11 patients achieved either a complete cytogenetic (n=2) or molecular (n=9) remission. Nine patients remain in molecular remission at a median follow-up of 29 months, seven of whom had received DLI alone as treatment for second relapse, one DLI plus imatinib and one imatinib alone. Toxicity following DLI for second relapse was low. Longer follow-up will be required to see if these second DLI-induced remissions will be durable.
Artemether-Soluplus Hot-Melt Extrudate Solid Dispersion Systems for Solubility and Dissolution Rate Enhancement with Amorphous State Characteristics

This work studied artemether (ARTM) solid dispersion (SD) formulation using mixture of polymer excipient Soluplus, PEG 400, Lutrol F127, and Lutrol F68 melts at temperatures lower than the melting point of ARTM using a laboratory-size, single-screw rotating batch extruder. The effects of three surfactants PEG 400, Lutrol F127, and Lutrol F68 and parameters like mixing temperature, screw rotating speed, and residence time were systematically studied. SEM, XRD, and FT-IR were employed to investigate the evolution of ARTM's dissolution into the molten excipient. Differential scanning calorimetry (DSC) was used to quantitatively study the melting enthalpy evolution of the drug. The results showed that the dissolution rate increased with increasing the ratio of polymer and surfactant to that of drug. It was concluded that the dissolution of the drug in the polymer melt is a convective diffusion process and that laminar distributive mixing can significantly enhance the dissolution rate. The aqueous solubility and dissolution rate of prepared solid dispersion were significantly enhanced. In vitro antimalarial studies revealed marked improvement in IC50 values. Thus hot-melt extrusion (HME) is a promising technology for improving solubility and dissolution profile of ARTM.
Singularity and decay estimates in superlinear problems via liouville-type theorems. Part II: Parabolic equations

In this paper, we study some new connections between parabolic Liouvilletype theorems and local and global properties of nonnegative classical solutions to superlinear parabolic problems, with or without boundary conditions. Namely, we develop a general method for derivation of universal, pointwise a priori estimates of solutions from Liouville-type theorems, which unifies and improves many results concerning a priori bounds, decay estimates and initial and final blow-up rates. For example, for the equation ut−∆u = up on a domain Ω, possibly unbounded and not necessarily convex, we obtain initial and final blow-up rate estimates of the form u(x, t) ≤ C(Ω, p) (1 + t 1 p−1 + (T − t) 1 p−1 ). Our method is based on rescaling arguments combined with a key “doubling” property, and it is facilitated by parabolic Liouville-type theorems for the whole ∗Supported in part by NSF Grant DMS-0400702 †Supported in part by VEGA Grant 1/3021/06
Growth processes in teeth distinguish modern humans from Homo erectus and earlier hominins

A modern human-like sequence of dental development, as a proxy for the pace of life history, is regarded as one of the diagnostic hallmarks of our own genus Homo. Brain size, age at first reproduction, lifespan and other life-history traits correlate tightly with dental development. Here we report differences in enamel growth that show the earliest fossils attributed to Homo do not resemble modern humans in their development. We used daily incremental markings in enamel to calculate rates of enamel formation in 13 fossil hominins and identified differences in this key determinant of tooth formation time. Neither australopiths nor fossils currently attributed to early Homo shared the slow trajectory of enamel growth typical of modern humans; rather, both resembled modern and fossil African apes. We then reconstructed tooth formation times in australopiths, in the ∼1.5-Myr-old Homo erectus skeleton from Nariokotome, Kenya, and in another Homo erectus specimen, Sangiran S7-37 from Java. These times were shorter than those in modern humans. It therefore seems likely that truly modern dental development emerged relatively late in human evolution.
When Action Observation Facilitates Visual Perception: Activation in Visuo-Motor Areas Contributes to Object Recognition.

Recent evidence suggests an interaction between the ventral visual-perceptual and dorsal visuo-motor brain systems during the course of object recognition. However, the precise function of the dorsal stream for perception remains to be determined. The present study specified the functional contribution of the visuo-motor system to visual object recognition using functional magnetic resonance imaging and event-related potential (ERP) during action priming. Primes were movies showing hands performing an action with an object with the object being erased, followed by a manipulable target object, which either afforded a similar or a dissimilar action (congruent vs. incongruent condition). Participants had to recognize the target object within a picture-word matching task. Priming-related reductions of brain activity were found in frontal and parietal visuo-motor areas as well as in ventral regions including inferior and anterior temporal areas. Effective connectivity analyses suggested functional influences of parietal areas on anterior temporal areas. ERPs revealed priming-related source activity in visuo-motor regions at about 120 ms and later activity in the ventral stream at about 380 ms. Hence, rapidly initiated visuo-motor processes within the dorsal stream functionally contribute to visual object recognition in interaction with ventral stream processes dedicated to visual analysis and semantic integration.
THE APPROXIMATE AND EXACT SOLUTIONS OF THE FRACTIONAL-ORDER DELAY DIFFERENTIAL EQUATIONS USING LEGENDRE SEUDOSPECTRAL METHOD

Fractional differential equations have recently been applied in various area of engineering, science, finance, applied mathematics, bio-engineering and others. However, many researchers remain unaware of this field. In this paper, an efficient numerical method for solving the fractional delay differential equations (FDDEs) is considered. The fractional derivative is described in the Caputo sense. The method is based upon Legendre approximations. The properties of Legendre polynomials are utilized to reduce FDDEs to linear or nonlinear system of algebraic equations. Numerical simulation with the exact solutions of FDDEs is presented. AMS Subject Classification: 34A08, 34K37
The molecular mechanism of action of bactericidal gold nanoparticles on Escherichia coli.

This work examines the molecular mechanism of action of a class of bactericidal gold nanoparticles (NPs) which show potent antibacterial activities against multidrug-resistant Gram-negative bacteria by transcriptomic and proteomic approaches. Gold NPs exert their antibacterial activities mainly by two ways: one is to collapse membrane potential, inhibiting ATPase activities to decrease the ATP level; the other is to inhibit the subunit of ribosome from binding tRNA. Gold NPs enhance chemotaxis in the early-phase reaction. The action of gold NPs did not include reactive oxygen species (ROS)-related mechanism, the cause for cellular death induced by most bactericidal antibiotics and nanomaterials. Our investigation would allow the development of antibacterial agents that target the energy-metabolism and transcription of bacteria without triggering the ROS reaction, which may be at the same time harmful for the host when killing bacteria.
The Impact of mHealth Interventions: Systematic Review of Systematic Reviews

BACKGROUND
Mobile phone usage has been rapidly increasing worldwide. mHealth could efficiently deliver high-quality health care, but the evidence supporting its current effectiveness is still mixed.


OBJECTIVE
We performed a systematic review of systematic reviews to assess the impact or effectiveness of mobile health (mHealth) interventions in different health conditions and in the processes of health care service delivery.


METHODS
We used a common search strategy of five major scientific databases, restricting the search by publication date, language, and parameters in methodology and content. Methodological quality was evaluated using the Measurement Tool to Assess Systematic Reviews (AMSTAR) checklist.


RESULTS
The searches resulted in a total of 10,689 articles. Of these, 23 systematic reviews (371 studies; more than 79,665 patients) were included. Seventeen reviews included studies performed in low- and middle-income countries. The studies used diverse mHealth interventions, most frequently text messaging (short message service, SMS) applied to different purposes (reminder, alert, education, motivation, prevention). Ten reviews were rated as low quality (AMSTAR score 0-4), seven were rated as moderate quality (AMSTAR score 5-8), and six were categorized as high quality (AMSTAR score 9-11). A beneficial impact of mHealth was observed in chronic disease management, showing improvement in symptoms and peak flow variability in asthma patients, reducing hospitalizations and improving forced expiratory volume in 1 second; improving chronic pulmonary diseases symptoms; improving heart failure symptoms, reducing deaths and hospitalization; improving glycemic control in diabetes patients; improving blood pressure in hypertensive patients; and reducing weight in overweight and obese patients. Studies also showed a positive impact of SMS reminders in improving attendance rates, with a similar impact to phone call reminders at reduced cost, and improved adherence to tuberculosis and human immunodeficiency virus therapy in some scenarios, with evidence of decrease of viral load.


CONCLUSIONS
Although mHealth is growing in popularity, the evidence for efficacy is still limited. In general, the methodological quality of the studies included in the systematic reviews is low. For some fields, its impact is not evident, the results are mixed, or no long-term studies exist. Exceptions include the moderate quality evidence of improvement in asthma patients, attendance rates, and increased smoking abstinence rates. Most studies were performed in high-income countries, implying that mHealth is still at an early stage of development in low-income countries.