LLukas22/scidocs huggingface dataset:
The effect of a partially hydrolysed formula based on rice protein in the treatment of infants with cow’s milk protein allergy

Infants diagnosed with allergy to cow's milk protein (CMP) are fed extensively hydrolysed cow's milk formulas, modified soy formulas or even amino acid-based formulas. Hydrolysed rice protein infant formulas have become available and have been shown to be well tolerated by these infants. A prospective open, randomized clinical study to compare the clinical tolerance of a new hydrolysed rice protein formula (HRPF) with an extensively hydrolysed CMP formula (EHF) in the feeding of infants with IgE-mediated cow's milk allergy. Ninety-two infants (46 boys and 46 girls, mean age 4.3 months, range 1.1-10.1 months) diagnosed with IgE-mediated cow's milk allergy were enrolled in the study. Clinical tolerance to the formula products was tested. Clinical evaluation included skin prick tests with whole cow's milk, soya and rice as well as antigens of CMP (beta-lactoglobulin, alpha-lactalbumin, casein and bovine seroalbumin), HRPF and EHF and specific IgE determinations to CMP using CAP technology. Patients were randomized to receive either an EHF based on CMP or a new HRPF. Follow-up was at 3, 6, 12, 18 and 24 months. Growth parameters were measured at each visit. One infant showed immediate allergic reaction to EHF, but no reaction was shown by any infant in the HRPF group. The number of infants who did not become tolerant to CMP during the study was not statistically different between the two groups. Measurement of IgE levels of infants allergic to CMP during the study showed no significant differences between the two formula groups. Growth parameters were in the normal range and similar between groups. In this study, the HRPF was well tolerated by infants with moderate to severe symptoms of IgE-mediated CMP allergy. Children receiving this formula showed similar growth and development of clinical tolerance to those receiving an EHF. In accordance with current guidelines, this HRPF was tolerated by more than 90% of children with CMP allergy and therefore could provide an adequate and safe alternative to CMP-hydrolysed formulas for these infants.
A Study of multilabel text classification and the effect of label hierarchy

Text classification has traditionally been one of the most popular problems in information retreival, natural language processing and machine learning. In the simplest case, the task of text classification [1] is as follows: A set of training documents T = {X1, X2, ...Xm} , each labelled with a class value from a set of k distinct labels, from the set {1, 2, ..k}, is used to learn a classification model, that captures the relationship between features in the documents and their labels. Subsequently, for a test document with unknown label, the model is used to predict a label. The problem of text classification finds wide appeal in various domains for tasks such as (i) News selection and grouping, (ii) Document organization in digital libraries, websites, social feeds,etc., (iii) Email classification including spam filtering. A variation of this problem in which each document can belong to any number of classes (labels) is referred to as a multilabel text classification problem. An extension to such a problem in which the labels are interrelated by a categorical hierarchy is referred to as a hierarchical text classification problem. In this project, we • study the task of multilabel text classification on real world datasets
A Hybrid Machine Learning System for Stock Market Forecasting

A hybrid machine learning system based on Genetic Algorithm (GA) and Time Series Analysis is proposed. In stock market, a technical trading rule is a popular tool for analysts and users to do their research and decide to buy or sell their shares. The key issue for the success of a trading rule is the selection of values for all parameters and their combinations. However, the range of parameters can vary in a large domain, so it is difficult for users to find the best parameter combination. In this paper, we present the Genetic Algorithm (GA) to overcome the problem in two steps. First, setting a sub-domain of the parameters with GA. Second, finding a near optimal value in the sub domain with GA and Time Series Analysis in a very reasonable time. INTRODUCTION Stock market prediction is regarded as a challenging task in financial time-series forecasting. This is primarily because of the uncertainties involved in the movement of the market. Many factors interact in the stock market including political events, general economic conditions, and traders ’expectations. Therefore, predicting market price movements is quite difficult. Increasingly, according to academic investigations, movements in market prices are not random. Rather, they behave in a highly non-linear, dynamic manner. Also, the ability to predict the direction and not the exact value of the future stock prices is the most important factor in making money using financial prediction. All the investor needs to know to make a buying or selling decision is the expected direction of the stock. Studies have also shown that predicting direction as compared to value can generate higher profit (Chen, Leung, & Daouk, 2003). TIME SERIES ANALYSIS Forecasting, or predicting, is an essential tool in any decision-making process. Its uses vary from determining inventory requirements for a local shoe store to estimating the annual sales of video games. The quality of the forecasts management can make is strongly related to the information that can be extracted and used from past data. Time-series analysis is one quantitative method we used to determine patterns in data collected over time. Time-series analysis is used to detect patterns of change in statistical information over regular intervals of time. We project these patterns to arrive at an estimate for the future. Thus Time-series analysis helps us cope with uncertainty about the future.
The reacTable*: A Collaborative Musical Instrument

The reacTable* is a novel multi-user electro-acoustic musical instrument with a tabletop tangible user interface. In this paper we focus on the various collaborative aspects of this new instrument as well as on some of the related technical details such as the networking infrastructure. The instrument can be played both in local and remote collaborative scenarios and was designed from the very beginning to serve as a musical instrument for several simultaneous players
Time-Delay Observables for Koopman : Theory and Applications

Nonlinear dynamical systems are ubiquitous in science and engineering, yet many issues still exist related to the analysis and prediction of these systems. Koopman theory circumvents these issues by transforming the finite-dimensional nonlinear dynamics to a linear dynamical system of functions in an infinite-dimensional Hilbert space of observables. The eigenfunctions of the Koopman operator evolve linearly in time and thus provide a natural coordinate system for simplifying the dynamical behaviors of the system. We consider a family of observable functions constructed by projecting the delay coordinates of the system onto the eigenvectors of the autocorrelation function, which can be regarded as continuous SVD basis vectors for time-delay observables. We observe that these functions are the most parsimonious basis of observables for a system with Koopman mode decomposition of order N , in the sense that the associated Koopman eigenfunctions are guaranteed to lie in the span of the first N of these coordinates. We conjecture and prove a number of theoretical results related to the quality of these approximations in the more general setting where the system has mixed spectra or the coordinates are otherwise insufficient to capture the full spectral information. We prove a related and very general result that the dynamics of the observables generated by projecting delay coordinates onto an arbitrary orthonormal basis are systemindependent and depend only on the choice of basis, which gives a highly efficient way of computing representations of the Koopman operator in these coordinates. We show that this formalism provides a theoretical underpinning for the empirical results in [8], which found that chaotic dynamical systems can be approximately factored into intermittently forced linear systems when viewed in delay coordinates. Finally, we compute these time delay observables for a number of example dynamical systems and show that empirical results match our theory.
Surviving and Thriving With Cancer Using a Web-Based Health Behavior Change Intervention: Randomized Controlled Trial

BACKGROUND
Given the substantial improvements in cancer screening and cancer treatment in the United States, millions of adult cancer survivors live for years following their initial cancer diagnosis and treatment. However, latent side effects can occur and some symptoms can be alleviated or managed effectively via changes in lifestyle behaviors.


OBJECTIVE
The purpose of this study was to test the effectiveness of a six-week Web-based multiple health behavior change program for adult survivors.


METHODS
Participants (n=352) were recruited from oncology clinics, a tumor registry, as well as through online mechanisms, such as Facebook and the Association of Cancer Online Resources (ACOR). Cancer survivors were eligible if they had completed their primary cancer treatment from 4 weeks to 5 years before enrollment. Participants were randomly assigned to the Web-based program or a delayed-treatment control condition.


RESULTS
In total, 303 survivors completed the follow-up survey (six months after completion of the baseline survey) and participants in the Web-based intervention condition had significantly greater reductions in insomnia and greater increases in minutes per week of vigorous exercise and stretching compared to controls. There were no significant changes in fruit and vegetable consumption or other outcomes.


CONCLUSIONS
The Web-based intervention impacted insomnia and exercise; however, a majority of the sample met or exceeded national recommendations for health behaviors and were not suffering from depression or fatigue at baseline. Thus, the survivors were very healthy and well-adjusted upon entry and their ability to make substantial health behavior changes may have been limited. Future work is discussed, with emphasis placed on ways in which Web-based interventions can be more specifically analyzed for benefit, such as in regard to social networking.


TRIAL REGISTRATION
Clinicaltrials.gov NCT00962494; http://www.clinicaltrials.gov/ct2/show/NCT00962494 (Archived by WebCite at http://www.webcitation.org/6NIv8Dc6Q).
Mercury capture by native fly ash carbons in coal-fired power plants.

The control of mercury in the air emissions from coal-fired power plants is an on-going challenge. The native unburned carbons in fly ash can capture varying amounts of Hg depending upon the temperature and composition of the flue gas at the air pollution control device, with Hg capture increasing with a decrease in temperature; the amount of carbon in the fly ash, with Hg capture increasing with an increase in carbon; and the form of the carbon and the consequent surface area of the carbon, with Hg capture increasing with an increase in surface area. The latter is influenced by the rank of the feed coal, with carbons derived from the combustion of low-rank coals having a greater surface area than carbons from bituminous- and anthracite-rank coals. The chemistry of the feed coal and the resulting composition of the flue gas enhances Hg capture by fly ash carbons. This is particularly evident in the correlation of feed coal Cl content to Hg oxidation to HgCl2, enhancing Hg capture. Acid gases, including HCl and H2SO4 and the combination of HCl and NO2, in the flue gas can enhance the oxidation of Hg. In this presentation, we discuss the transport of Hg through the boiler and pollution control systems, the mechanisms of Hg oxidation, and the parameters controlling Hg capture by coal-derived fly ash carbons.
In situ gel systems as 'smart' carriers for sustained ocular drug delivery.

INTRODUCTION
In situ gel systems refer to a class of novel delivery vehicles, composed of natural, semisynthetic or synthetic polymers, which present the unique property of sol-gel conversion on receipt of biological stimulus.


AREAS COVERED
The present review summarizes the latest developments in in situ gel technology, with regard to ophthalmic drug delivery. Starting with the mechanism of ocular absorption, the review expands on the fabrication of various polymeric in situ gel systems, made up of two or more polymers presenting multi-stimuli sensitivity, coupled with other interesting features, such as bio-adhesion, enhanced penetration or sustained release. Various key issues and challenges in this area have been addressed and critically analyzed.


EXPERT OPINION
The advent of in situ gel systems has inaugurated a new transom for 'smart' ocular delivery. By virtue of possessing stimuli-responsive phase transition properties, these systems can easily be administered into the eye, similar to normal eye drops. Their unique gelling properties endow them with special features, such as prolonged retention at the site of administration, followed by sustained drug release. Despite the superiority of these systems as compared with conventional ophthalmic formulations, further investigations are necessary to address the toxicity issues, so as to minimize regulatory hurdles during commercialization.
Comp.specification.z and Z FORUM Frequently Asked Questions

This appendix provides some details on how to access information on Z, particularly electronically. It has been generated from a message that is updated and sent out monthly on international computer networks.
Crowdfunding : An Industrial Organization Perspective ∗

The first objective of the paper is to identifiy a number of issues related to crowdfunding that are worth studying from an industrial organization (IO) perspective. To this end, we first propose a definition of crowdfunding; next, on the basis on a previous empirical study, we isolate what we believe are the main features of crowdfunding; finally, we point to a number of strands of the literature that could be used to study the various features of crowdfunding. The second objective of the paper is to propose some preliminary efforts towards the modelization of crowdfunding. In a first model, we associate crowdfunding with pre-ordering and price discrimination, and we study the conditions under which crowdfunding is preferred to traditional forms of external funding. In a second model, we see crowdfunding as a way to make a product better known by the consumers and we give some theoretical underpinning for the empirical finding that non-profit organizations tend to be more successful in using crowdfunding. JEL classification codes: G32, L11, L13, L15, L21, L31
Janus: a general purpose WebRTC gateway

This paper deals with the design and implementation of Janus, a general purpose, open source WebRTC gateway. Details will be provided on the architectural choices we took for Janus, as well as on the APIs we made available to extend and make use of it. Examples of how the gateway can be used for complex WebRTC applications are presented, together with some experimental results we collected during the development process.
Personalised Learning: Educational, Technological and Standardisation Perspective

The e-Learning paradigm shift capitalises on two main aspect: the elimination of the barriers of time and distance, and the personalisation of the learners’ experience. The current trend in education and training emphasises on identifying methods and tools for delivering just-in-time, on-demand knowledge experiences tailored individual learners, taking into consideration their differences in skills level, perspectives, culture and other educational contexts. This paper reviews the shift towards personalised learning, from an educational, technological and standardisation perspective.
Endoscopic ligation (“Loop-And-Let-Go”) is effective treatment for large colonic lipomas: a prospective validation study

BACKGROUND
Colonic lipomas (CL) are rare benign adipose tumours usually found incidentally during colonoscopy. Endoscopic resection of symptomatic large CL remains controversial, since significant rates of perforation have been reported. In recent years, a novel technique for removal of large CL has been described, consisting of looping and ligating the lipoma with a nylon snare. The aim of our study was to evaluate the safety and efficacy of the "loop and let go" technique for large colon lipomas in a large case series.


METHODS
Consecutive patients referred to our institution for colonoscopy were eligible for the study. The diagnosis of CL was confirmed endoscopically by "pillow" and "naked fat" signs. Following diagnosis, lipomas were looped and ligated by endoloop. Follow-up colonoscopies were scheduled at 1- and 3-months interval.


RESULTS
A total of 11 patients with large CL were enrolled in study. The indications for the colonoscopy included altered bowel habits (7 patients, 64%), screening for colorectal neoplasm (3 pts, 27%) and lower gastrointestinal bleeding (1 pts, 9%). The median lesion size was 3 cm (range 2,5-6 cm). Lesions were located at the hepatic flexure in 4 patients (36%), cecum and ascending colon (4 pts, 36%), rectosigmoid (2 pts, 18%) and transverse colon (1 pts, 9%). There were no immediate and late complications. On follow-up (median follow-up time 11.9 months, range 8-24), there was one small residual lipoma (<1 cm).


CONCLUSION
The results of this study confirm that "loop-and-let-go" technique is safe and efficacious treatment of large colonic lipomas.
The impact of the quality of care and other factors on progression of chronic kidney disease in Thai patients with Type 2 Diabetes Mellitus: A nationwide cohort study

OBJECTIVE
The present study investigates the impact of quality of care (QoC) and other factors on chronic kidney disease (CKD) stage progression among Type 2 Diabetes Mellitus (T2DM) patients.


METHODS
This study employed a retrospective cohort from a nationwide Diabetes and Hypertension study involving 595 Thai hospitals. T2DM patients who were observed at least 2 times in the 3 years follow-up (between 2011-2013) were included in our study. Ordinal logistic mixed effect regression modeling was used to investigate the association between the QoC and other factors with CKD stage progression.


RESULTS
After adjusting for covariates, we found that the achievement of the HbA1c clinical targets (≤7%) was the only QoC indicator protective against the CKD stage progression (adjusted OR = 0.76; 95%CI = 0.59-0.98; p<0.05). In terms of other covariates, age, occupation, type of health insurance, region of residence, HDL-C, triglyceride, hypertension and insulin sensitizer were also strongly associated with CKD stage progression.


CONCLUSIONS
This cohort study demonstrates the achievement of the HbA1c clinical target (≤7%) is the only QoC indicator protective against progression of CKD stage. Neither of the other clinical targets (BP and LDL-C) nor any process of care targets could be shown to be associated with CKD stage progression. Therefore, close monitoring of blood sugar control is important to slow CKD progression, but long-term prospective cohorts are needed to gain better insights into the impact of QoC indicators on CKD progression.
An Assessment of the Hospital Disease Burden and the Facilities for the In-hospital Care of Trauma in KwaZulu-Natal, South Africa

Trauma is a significant cause of morbidity and mortality in South Africa. The present study was designed to review the hospital trauma disease burden in light of the facilities available for the care of the injured in KwaZulu-Natal (KZN), South Africa’s most populous province. The primary outcomes were the annual hospital burden of trauma in KZN, determined through data extrapolation, and evaluation of the data in light of available hospital facilities within the province of KZN, a developing province. The data were obtained through review of the trauma load in relation to all emergency cases at all levels of hospitals. Hospital administrators in KZN were requested to submit trauma caseloads for the months of March and September 2010. Caseloads were reviewed to determine the trauma load for the province per category using two extrapolation methods to determine the predicted range of annual incidence of trauma, intentional versus non-intentional trauma ratios and population-related incidence of trauma. The results were GIS mapped to demonstrate variations across districts. Hospital data were obtained from assessments of structure, process, and personnel undertaken prior to a major sporting event. These were compared to the ideal facilities required for accreditation of trauma care facilities of the Trauma Society of South Africa and other established documents. Data were obtained from 36 of the 47 public hospitals in KZN that manage acute emergency cases. The predicted annual trauma incidence in KZN ranges from 124,000 to 125,000, or 12.9 per 1,000 population. This would imply a national public hospital trauma load on the order of at least 750,000 cases per year. Most hospitals are required to treat trauma; however, within KZN many hospitals do not have adequate personnel, medical equipment, or structural integrity to be formally accredited as trauma care facilities in terms of existing criteria. There is a significant trauma load that consumes vital emergency center resources. Most hospitals will need extensive upgrading to provide appropriate care for trauma. An inclusive trauma system needs to be formalized and funded, especially in light of the planned National Health Insurance for South Africa
A preliminary exploration of the feasibility of offering men information about potential prostate cancer treatment options before they know their biopsy results

BACKGROUND
A small pre-test study was conducted to ascertain potential harm and anxiety associated with distributing information about possible cancer treatment options at the time of biopsy, prior to knowledge about a definitive cancer diagnosis. Priming men about the availability of multiple options before they have a confirmed diagnosis may be an opportunity to engage patients in more informed decision-making.


METHODS
Men with an elevated PSA test or suspicious Digital Rectal Examination (DRE) who were referred to a urology clinic for a biopsy were randomized to receive either the clinic's usual care (UC) biopsy instruction sheet (n = 11) or a pre-biopsy educational (ED) packet containing the biopsy instruction sheet along with a booklet about the biopsy procedure and a prostate cancer treatment decision aid originally written for newly diagnosed men that described in detail possible treatment options (n = 18).


RESULTS
A total of 62% of men who were approached agreed to be randomized, and 83% of the ED group confirmed they used the materials. Anxiety scores were similar for both groups while awaiting the biopsy procedure, with anxiety scores trending lower in the ED group: 41.2 on a prostate-specific anxiety instrument compared to 51.7 in the UC group (p = 0.13). ED participants reported better overall quality of life while awaiting biopsy compared to the UC group (76.4 vs. 48.5, p = 0.01). The small number of men in the ED group who went on to be diagnosed with cancer reported being better informed about the risks and side effects of each option compared to men diagnosed with cancer in the UC group (p = 0.07). In qualitative discussions, men generally reported they found the pre-biopsy materials to be helpful and indicated having information about possible treatment options reduced their anxiety. However, 2 of 18 men reported they did not want to think about treatment options until after they knew their biopsy results.


CONCLUSIONS
In this small sample offering pre-biopsy education about potential treatment options was generally well received by patients, appeared to be beneficial to men who went on to be diagnosed, and did not appear to increase anxiety unnecessarily among those who had a negative biopsy.