LLukas22/scidocs huggingface dataset:
Comparison of endoscopic gastric mucosa features after administration of piroxicam to meloxicam and their correlation with dyspepsia symptoms in elderly patient with knee osteoarthritis.

AIM
to know the effect of piroxicam (COX-1 and COX-2 inhibitor NSAID) and meloxicam (selective COX-2 inhibitor NSAID) against the gastric mucosa.


METHODS
a random, double-blind-parallel study and repeat measurement against 20 elderly-patients with knee-OA was conducted. Patients were divided into 2 equal groups, every group got piroxicam 20 mg/day or meloxicam 15 mg/day for 3 weeks. On the second group, sukralfat 2 x 1 g/day were given. To examine the difference before and after treatment, we used Wilcoxon signed rank test, to examine the difference within those groups we used Mann-whitney U test, to examine the correlation between endoscopic score and dyspepsia, we used the Spearman correlation test with significant correlation interpretation by Guilford rules.


RESULTS
one of piroxicam group was resigned, so that there was 19 person left to complete this study. Piroxicam has caused elevation of endoscopic score in 78% subject compared to the beginning of study, and 22% of the subject has developed ulcers. Alteration of endoscopic feature after administration of this piroxicam was statistically significant (p< 0,05). Mild dyspepsia symptoms after piroxicam administration were positive on 67% subjects (p< 0,05). After administration of meloxicam, 40% subjects have elevated endoscopic score compared to beginning of the study (p< 0,05). Mild dyspepsia symptoms after meloxicam administration were positive on 40% subjects (p> 0,05). Meloxicam has less elevation of endoscopic score compared to the piroxicam (p< 0,05). By statistics, both of groups showed no difference in dyspepsia symptoms (p> 0,05). There was no significant correlation between elevation of endoscopic score and dyspepsia on both of groups. Nevertheless, it tends to have weak positive correlation (piroxicam group r= 0,306, p> 0,05, meloxicam group r= 0,330, p> 0,05).


CONCLUSION
on this study, we conclude that the administration of either piroxicam or meloxicam in elderly-patient with knee-OA has caused the gastric mucosa impairment. The impairment after meloxicam administration is milder than piroxicam. There is no significant difference of dyspepsia symptoms in both of groups. There is correlation between endoscopic gastric mucosa features with the dyspepsia symptoms.
Body dysmorphic disorder. A survey of fifty cases.

BACKGROUND
Body dysmorphic disorder (BDD) consists of a preoccupation with an 'imagined' defect in appearance which causes significant distress or impairment in functioning. There has been little previous research into BDD. This study replicates a survey from the USA in a UK population and evaluates specific measures of BDD.


METHOD
Cross-sectional interview survey of 50 patients who satisfied DSM-IV criteria for BDD as their primary disorder.


RESULTS
The average age at onset was late adolescence and a large proportion of patients were either single or divorced. Three-quarters of the sample were female. There was a high degree of comorbidity with the most common additional Axis l diagnosis being either a mood disorder (26%), social phobia (16%) or obsessive-compulsive disorder (6%). Twenty-four per cent had made a suicide attempt in the past. Personality disorders were present in 72% of patients, the most common being paranoid, avoidant and obsessive-compulsive.


CONCLUSIONS
BDD patients had a high associated comorbidity and previous suicide attempts. BDD is a chronic handicapping disorder and patients are not being adequately identified or treated by health professionals.
Web Engineering: Creating a Discipline among Disciplines

discipline among disciplines, cutting across computer science, information systems, and software engineering, as well as benefitting from several non-IT specializations. Intertwining so many disciplines presents a unique problem for organization and development. Here we discuss Web engineering’s classification, define its characteristics, and contrast its present issues with previous problems in information technology. W hile the World Wide Web may be “just another application of distributed computing” to some computer scientists, it is now widely acknowledged as a medium to deploy and develop applications. At the same time, there’s a certain déjà vu about the development of Webbased applications, reminiscent of the 1960s, before computing professionals acknowledged that computer applications involved much more than expertise in programming and general intelligence. Today’s Web-based application developers generally seem young, full of energy, conversant in new technologies, and as though they’re enjoying themselves (analogous to the programming fraternity of the 1960s). In contrast, those in charge of corporate applications and systems generally seem old, tired, and weighed down by legacy systems (the same perceptions we had of people using unit record systems). The similarities of this scenario are actually much more in-depth than simply discerning outward appearances. There are real dangers that the new Web technology and the pace at which it’s changing may divide the information technology community, and the Web-based application developers may repeat the mistakes of their predecessors. The 1960s programmers generally disregarded the older systems and systems personnel to build applications anew—reflecting their youthful exuberance and technological superiority—with insufficient attention to the users’ needs and without sound methods of building and testing the applications. These themes have dominated software engineering and information systems research and conferences for more than 30 years. The information technology community is accustomed to continuous change and has responded to change in the past by taking stock and creating new fields of study. Here, then, we take a close look at Web-based application development and argue that there’s more to such work than computer science, software engineering, and information systems encompass. Our community proposed the term “Web engineering” in 1998 with the first international workshop on Web engineering,1 and this has since been used by many. However, the term Web engineering is still unfamiliar to many and not fully understood. We argue that the information technology community should view Web engineering as a new, emerging discipline in its own right, rather than subsuming it mainly under software engineering.2
Systematic investigation of gastrointestinal diseases in China (SILC): validation of survey methodology

BACKGROUND
Symptom-based surveys suggest that the prevalence of gastrointestinal diseases is lower in China than in Western countries. The aim of this study was to validate a methodology for the epidemiological investigation of gastrointestinal symptoms and endoscopic findings in China.


METHODS
A randomized, stratified, multi-stage sampling methodology was used to select 18,000 adults aged 18-80 years from Shanghai, Beijing, Xi'an, Wuhan and Guangzhou. Participants from Shanghai were invited to provide blood samples and undergo upper gastrointestinal endoscopy. All participants completed Chinese versions of the Reflux Disease Questionnaire (RDQ) and the modified Rome II questionnaire; 20% were also invited to complete the 36-item Short Form Health Survey (SF-36) and Epworth Sleepiness Scale (ESS). The psychometric properties of the questionnaires were evaluated statistically.


RESULTS
The study was completed by 16,091 individuals (response rate: 89.4%), with 3219 (89.4% of those invited) completing the SF-36 and ESS. All 3153 participants in Shanghai provided blood samples and 1030 (32.7%) underwent endoscopy. Cronbach's alpha coefficients were 0.89, 0.89, 0.80 and 0.91, respectively, for the RDQ, modified Rome II questionnaire, ESS and SF-36, supporting internal consistency. Factor analysis supported construct validity of all questionnaire dimensions except SF-36 psychosocial dimensions.


CONCLUSION
This population-based study has great potential to characterize the relationship between gastrointestinal symptoms and endoscopic findings in China.
Next-generation PON-part I: Technology roadmap and general requirements

Gigabit-class passive optical networks have been standardized and are now being deployed. This article presents possible migration scenarios toward the next-generation PON and proposes a technology roadmap of evolutionary growth (termed NG-PON1) vs. revolutionary change (termed NG-PON2). This article then details the general requirements for NG-PON1 to support various popular applications many service providers expressed interests on as well as to enable smooth migration from Gigabit PON.
FEVER: a large-scale dataset for Fact Extraction and VERification

In this paper we introduce a new publicly available dataset for verification against textual sources, FEVER: Fact Extraction and VERification. It consists of 185,445 claims generated by altering sentences extracted from Wikipedia and subsequently verified without knowledge of the sentence they were derived from. The claims are classified as SUPPORTED, REFUTED or NOTENOUGHINFO by annotators achieving 0.6841 in Fleiss κ. For the first two classes, the annotators also recorded the sentence(s) forming the necessary evidence for their judgment. To characterize the challenge of the dataset presented, we develop a pipeline approach and compare it to suitably designed oracles. The best accuracy we achieve on labeling a claim accompanied by the correct evidence is 31.87%, while if we ignore the evidence we achieve 50.91%. Thus we believe that FEVER is a challenging testbed that will help stimulate progress on claim verification against textual sources.
NCBO Annotator : Semantic Annotation of Biomedical Data

The National Center for Biomedical Ontology Annotator is an ontology-based web service for annotation of textual biomedical data with biomedical ontology concepts. The biomedical community can use the Annotator service to tag datasets automatically with concepts from more than 200 ontologies coming from the two most important set of biomedical ontology & terminology repositories: the UMLS Metathesaurus and NCBO BioPortal. Through annotation (or tagging) of datasets with ontology concepts, unstructured free-text data becomes structured and standardized. Such annotations contribute to create a biomedical semantic web that facilitates translational scientific discoveries by integrating annotated data.
Chemical Evolution of Clusters of Galaxies

The high metallicity of the intra–cluster medium (ICM) is generally interpreted on the base of the galactic wind scenario for elliptical galaxies. In this framework, we develop a toy–model to follow the chemical evolution of the ICM, formulated in analogy to chemical models for individual galaxies. Just as the ingredients for usual models are (a) the stellar yields, amount of metals newly synthesized and re-ejected by stars; (b) the Star Formation Rate and (c) the stellar Initial Mass Function (IMF), our model for clusters involves: (a’) “galactic yields” derived from galactic wind models of ellipticals; (b’) a parametric Galactic Formation Rate; (c’) a Press-Schechter-like Galactic Initial Mass Function. The model is used to test the response of the predicted metal content and abundance evolution of the ICM to varying input galactic models. The resulting luminosity function of cluster galaxies is also calculated, in order to constrain model parameters.
ATRIAS: Design and validation of a tether-free 3D-capable spring-mass bipedal robot

ATRIAS is a human-scale 3D-capable bipedal robot designed to mechanically embody the spring-mass model for dynamic walking and running. To help bring the extensive work on this theoretical model further into practice, we present the design and validation of a spring-mass robot that can operate in real-world settings (i.e. off-tether and without planarizing restraints). We outline the mechanisms and design choices necessary to meet these specifications, particularly ATRIAS’ four-bar series-elastic leg design. We experimentally demonstrate the following robot capabilities, which are characteristics of the target model. 1) We present the robot’s physical capability for both grounded and aerial gaits, including planar walking and sustained hopping, while being more efficient than similarly gait-versatile bipeds. 2) The robot can be controlled by enforcing quantities derived from the simpler spring-mass model, such as leg angles and leg forces. 3) ATRIAS replicates the center-of-mass dynamics of human hopping and (novelly) walking, a key spring-mass model feature. Lastly, we present dynamically stable stepping in 3D without external support, demonstrating that this theoretical model has practical potential for real-world locomotion.
Weight and body mass index in relation to irradiated volume and to overall survival in patients with oropharyngeal cancer: a retrospective cohort study

BACKGROUND
Weight loss is a common problem in patients with Squamous Cell Carcinoma of the Head and Neck (SCCHN) treated with radiotherapy (RT). The aims of the present study were to determine if treated volume (TV), as a measure of the radiation dose burden, can predict weight loss in patients with oropharyngeal cancer and to analyze weight loss and body mass index (BMI) in the same patient group in relation to 5-year overall survival.


METHODS
The ARTSCAN trial is a prospective, randomized, multicenter trial in patients with SCCHN. Nutritional data from the ARTSCAN trial were analyzed retrospectively using univariate and multivariate statistical methods based on information on percentage weight loss from the start of RT up to five months after the termination of RT (study cohort 1, n = 232) and information on patients' BMI at the start of RT (study cohort 2, n = 203). TV was defined as the volume of the patient receiving at least 95% of the prescribed dose. TV64.6 Gy encompasses macroscopic tumor and TV43.7 Gy elective lymph nodes of the neck.


RESULTS
TV64.6 Gy and TV43.7 Gy were both significantly correlated with higher weight loss up to five months after the termination of RT in study cohort 1 (p < 0.001 for both). BMI at the start of RT was shown to be a prognostic factor for 5-year overall survival in study cohort 2 but weight loss was not. The hazard ratios and 95% confidence intervals were 3.78 (1.46-9.75) and 2.57 (1.43-4.62) in patients with underweight and normal weight, respectively.


CONCLUSIONS
TV can predict weight loss during RT in patients with oropharyngeal cancer regardless of clinical stage. A high BMI (>25 kg/m2) at the start of RT is positively associated with survival in patients with oropharyngeal cancer.
From the Shortest Vector Problem to the Dihedral Hidden Subgroup Problem

In Quantum Computation and Lattice Problems [11] Oded Regev presented the first known connection between lattices and quantum computation, in the form of a quantum reduction from the poly(n)-unique shortest vector problem to the dihedral hidden subgroup problem by sampling cosets. This article contains a summary of Regev’s result.
A COUPLED-LINE BAND-STOP FILTER WITH THREE-SECTION TRANSMISSION-LINE STUBS AND WIDE UPPER PASSBAND PERFORMANCE

A novel band-stop filter with wide upper pass-band performance is proposed and discussed in this paper. This bandstop filter includes two three-section transmission-line stubs and a parallel coupled-line section. Because three-section transmission-line stubs and coupled-line section are used, this filter not only features good band-stop filtering property, but also has wide upper pass band. In order to verify this new filter circuit structure and its corresponding design theory, three groups of numerical examples are demonstrated. Finally, two practical band-stop filters using common microstrip technology are designed, simulated and measured. The simulated and measured results indicate that both the coupled-line section with weak coupling and two three-section stubs can improve the upper pass-band performance. Furthermore, the measured results of the second fabricated microstrip band-stop filter (Filter B) show that the 20-dB insertion-loss band-stop bandwidth at 0.46 GHz is 90MHz and the 1.2-dB transmission coefficient upper pass band is from 0.66GHz to 2.52GHz. Thus, the highest pass-band frequency is extended to larger than five times of the operating center frequency of stop band.
Dipeptidyl Peptidase-4 Inhibition by Vildagliptin and the Effect on Insulin Secretion and Action in Response to Meal Ingestion in Type 2 Diabetes 

OBJECTIVE
The purpose of this study was to determine the mechanism by which dipeptidyl peptidase-4 inhibitors lower postprandial glucose concentrations.


RESEARCH DESIGN AND METHODS
We measured insulin secretion and action as well as glucose effectiveness in 14 subjects with type 2 diabetes who received vildagliptin (50 mg b.i.d.) or placebo for 10 days in random order separated by a 3-week washout. On day 9 of each period, subjects ate a mixed meal. Insulin sensitivity (S(I)), glucose effectiveness, and beta-cell responsivity indexes were estimated using the oral glucose and C-peptide minimal models. At 300 min 0.02 unit/kg insulin was administered intravenously.


RESULTS
Vildagliptin reduced postprandial glucose concentrations (905 +/- 94 vs. 1,008 +/- 104 mmol/6 h, P = 0.02). Vildagliptin did not alter net S(I) (7.71 +/- 1.28 vs. 6.41 +/- 0.84 10(-4) dl x kg(-1) x min(-1) x muU(-1) x ml(-1), P = 0.13) or glucose effectiveness (0.019 +/- 0.002 vs. 0.018 +/- 0.002 dl x kg(-1) x min(-1), P = 0.65). However, the net beta-cell responsivity index was increased (35.7 +/- 5.2 vs. 28.9 +/- 5.2 10(-9) min(-1), P = 0.03) as was total disposition index (381 +/- 48 vs. 261 +/- 35 10(-14) dl x kg(-1) x min(-2) x pmol(-1) x l(-1), P = 0.006). Vildagliptin lowered postprandial glucagon concentrations (27.0 +/- 1.1 vs. 29.7 +/- 1.5 microg x l(-1) x 6 h(-1), P = 0.03), especially after administration of exogenous insulin (81.5 +/- 6.4 vs. 99.3 +/- 5.6 ng/l, P = 0.02).


CONCLUSIONS
Vildagliptin lowers postprandial glucose concentrations by stimulating insulin secretion and suppressing glucagon secretion but not by altered insulin action or glucose effectiveness. A novel observation is that vildagliptin alters alpha-cell responsiveness to insulin administration, but the significance of this action is as yet unclear.
Error characterization and coding schemes for flash memories

In this work, we use an extensive empirical database of errors induced by write, read, and erase operations to develop a comprehensive understanding of the error behavior of flash memories. Error characterization of MLC and SLC flash is given on the block, page, and bit level. Based on our error characterization in MLC flash, we propose an error-correcting scheme which outperforms the conventional BCH code. We compare several schemes which use an MLC block as an SLC block. Finally, an implementation of two-write WOM-codes in SLC flash is given as well as the BER for the first and second write.
Two Epoch Algorithms for Disaster Recovery

Remote backup copies of databases are often maintained to ensure availability of data even in the presence of extensive failures, for which local replication mechanisms may be inadequate. We present two versions of an epoch algorithm for maintaining a consistent remote backup copy of a database. The algorithms ensure scalability, which makes them suitable for very large databases. The correctness and the performance of the algorithms are discussed, and an additional application for distributed group commit is given.
Nurse staffing and patient mortality in intensive care units.

BACKGROUND
Research evidence suggests that nurse staffing influences patient outcomes.


OBJECTIVES
To examine the relationship between nurse staffing and patient mortality in Korean intensive care units (ICUs).


METHODS
Using survey and administrative databases, this study included 27,372 ICU patients discharged from 42 tertiary and 194 secondary hospitals. Ownership (public vs. private), location (metropolitan city vs. province), size, specialization of ICUs (specialized vs. mixed), physician staffing and nurse staffing, and years of nurse experience were included as hospital and ICU characteristics. Nurse staffing was measured as the ratio of average daily census to the total number of full-time equivalent registered nurses in ICUs. Age, gender, 26 categories of primary diagnoses, 16 groups of comorbid conditions, and source of payment were used for risk adjustment. Mortality was defined as deaths that occurred in the hospital or on the date of hospital discharge. Using SAS GLIMMIX procedures, multivariate logistic regression analysis was employed separately for tertiary and secondary hospitals.


RESULTS
In tertiary hospitals, a greater likelihood of dying was found among patients who were admitted to a mixed ICU (odds ratio [OR] = 1.61, 95% confidence interval [CI] = 1.14-2.26) and where there was no board-certified physician present for 4 or more hours per day (OR = 1.56, 95% CI = 1.20-2.01). In secondary hospitals, every additional patient per RN was associated with a 9% increase in the odds of dying (OR = 1.09, 95% CI = 1.04-1.14). Nurse experience had no significant relationship with mortality.


DISCUSSION
Nurse and physician staffing and specialization of ICUs impacted patient mortality. Associations differed in tertiary and secondary hospitals. Further investigation of the impact of organizational environments in ICUs is needed.
Verifying Continuous Time Markov Chains

We present a logical formalism for expressing properties of continuous time Markov chains. The semantics for such properties arise as a natural extension of previous work on discrete time Markov chains to continuous time. The major result is that the veriication problem is decidable; this is shown using results in algebraic and transcendental number theory.
Bioremediation of diesel-polluted soil using biostimulation as post-treatment after oxidation with Fenton-like reagents: assays in a pilot plant.

The present study focuses on the remediation of diesel-polluted soil using modified Fenton treatment coupled with inorganic NPK fertilizer ("Fenton+NPK"). Studies were carried out in a pilot plant containing 1 m(3) of sandy soil contaminated with 20,000 mg kg(-1) of diesel, placed outdoors at a temperature ranging between 5 and 10 °C. Results showed that NPK-fertilizer as post-treatment stimulated culturable degrading bacteria and enhanced dehydrogenase activity. Fenton+NPK treatment increased total petroleum hydrocarbon (TPH) removal efficacy. Natural attenuation removed 49% of TPH in the surface layer, 23% of TPH in the non-saturated layer and 4% of the TPH in the saturated layer, while the percentage removed of TPH after Fenton+NPK treatment was 58%, 57% and 32% respectively. The results from our study showed that, immediately after soil contamination, occurred a specialization and differentiation of the bacterial community, but after this initial modification, no significant changes of bacterial diversity was observed under natural attenuation conditions. In contrast, when the Fenton's reagent was applied a reduction of the bacterial biodiversity was observed. However, the post-biostimulation did enhance the degrading microbiota and stimulated their degrading biological activity. In conclusion, biostimulation, as a post-treatment step in chemical oxidation, is an effective solution to remediate hydrocarbon-polluted sites.