LLukas22/scidocs huggingface dataset:
Lazy Narrowing in a Graph Machine

The paper investigates the implementation of lazy narrowing in the framework of a graph reduction machine. By extending an appropriate architecture for purely functional languages an abstract graph narrowing machine for a functional logic language is constructed. The machine is capable of performing uni cation and backtracking. The techniques used in functional languages to cope with lazy evaluation are not directly applicable, but must be modi ed due to the logic component of the implemented language. A prototype implementation of the new machine has been developed.
Time course and predictors of health-related quality of life improvement and medication satisfaction in children diagnosed with attention-deficit/hyperactivity disorder treated with the methylphenidate transdermal system.

OBJECTIVE
The aim of this study was to evaluate the time course and predictors of improvement in health-related quality of life (HRQL) and medication satisfaction in children diagnosed with attention-deficit/hyperactivity disorder (ADHD) and treated with the methylphenidate transdermal system (MTS).


METHODS
Temporal relationships between ADHD symptoms, medication satisfaction, and HRQL measures were examined via latent growth curve, structural path, and growth mixture models.


RESULTS
Higher levels of medication satisfaction at the end of titration predicted greater increases in family HRQL (p=0.004) and, to a lesser extent, child HRQL (p=0.068) throughout the study. At 4 of 6 (p<0.05) and 5 of 6 (p<0.10) contemporaneous time points, ADHD symptoms predicted child HRQL. At 2 of 6 (p<0.05) and 3 of 6 (p<0.10) contemporaneous time points, ADHD symptoms predicted family HRQL. ADHD did not predict child or family HRQL improvements at subsequent time points. A uniform pattern of change for child HRQL was noted, with most HRQL change following the pattern of symptom change during titration. Three distinct patterns of change were noted for family HRQL.


CONCLUSIONS
In most cases, medication satisfaction, ADHD symptoms, and HRQL improved simultaneously, suggesting that HRQL was not a delayed response to improvement in symptoms. Children showed a uniform pattern of improvement in HRQL that followed symptom change; three distinct patterns of change were found for improvement in family HRQL.
Semiparallel deep neural network hybrid architecture: first application on depth from monocular camera

Publication Information Bazrafkan, Shabab , Javidnia, Hossein , Lemley, Joseph , & Corcoran, Peter (2018). Semiparallel deep neural network hybrid architecture: first application on depth from monocular camera. Journal of Electronic Imaging, 27(4), 19. doi: 10.1117/1.JEI.27.4.043041 Publisher Society of Photo-optical Instrumentation Engineers (SPIE) Link to publisher's version https://dx.doi.org/10.1117/1.JEI.27.4.043041
Electrocardiology and Risk Stratification Women , but not men , have prolonged QT interval if depressed after an acute coronary syndrome

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . CLINICAL RESEARCH Electrocardiology and Risk Stratification
Community Evolution Mining in Dynamic Social Networks

Data that encompasses relationships is represented by a graph of interconnected nodes. Social network analysis is the study of such graphs which examines questions related to structures and patterns that can lead to the understanding of the data and predicting the trends of social networks. Static analysis, where the time of interaction is not considered (i.e., the network is frozen in time), misses the opportunity to capture the evolutionary patterns in dynamic networks. Specifically, detecting the community evolutions, the community structures that changes in time, provides insight into the underlying behaviour of the network. Recently, a number of researchers have started focusing on identifying critical events that characterize the evolution of communities in dynamic scenarios. In this paper, we present a framework for modeling and detecting community evolution in social networks, where a series of significant events is defined for each community. A community matching algorithm is also proposed to efficiently identify and track similar communities over time. We also define the concept of meta community which is a series of similar communities captured in different timeframes and detected by our matching algorithm. We illustrate the capabilities and potential of our framework by applying it to two real datasets. Furthermore, the events detected by the framework is supplemented by extraction and investigation of the topics discovered for each community. c © 2011 Published by Elsevier Ltd.
A randomized study of endobronchial valves for advanced emphysema.

BACKGROUND
Endobronchial valves that allow air to escape from a pulmonary lobe but not enter it can induce a reduction in lobar volume that may thereby improve lung function and exercise tolerance in patients with pulmonary hyperinflation related to advanced emphysema.


METHODS
We compared the safety and efficacy of endobronchial-valve therapy in patients with heterogeneous emphysema versus standard medical care. Efficacy end points were percent changes in the forced expiratory volume in 1 second (FEV1) and the 6-minute walk test on intention-to-treat analysis. We assessed safety on the basis of the rate of a composite of six major complications.


RESULTS
Of 321 enrolled patients, 220 were randomly assigned to receive endobronchial valves (EBV group) and 101 to receive standard medical care (control group). At 6 months, there was an increase of 4.3% in the FEV1 in the EBV group (an increase of 1.0 percentage point in the percent of the predicted value), as compared with a decrease of 2.5% in the control group (a decrease of 0.9 percentage point in the percent of the predicted value). Thus, there was a mean between-group difference of 6.8% in the FEV1 (P=0.005). Roughly similar between-group differences were observed for the 6-minute walk test. At 12 months, the rate of the complications composite was 10.3% in the EBV group versus 4.6% in the control group (P=0.17). At 90 days, in the EBV group, as compared with the control group, there were increased rates of exacerbation of chronic obstructive pulmonary disease (COPD) requiring hospitalization (7.9% vs. 1.1%, P=0.03) and hemoptysis (6.1% vs. 0%, P=0.01). The rate of pneumonia in the target lobe in the EBV group was 4.2% at 12 months. Greater radiographic evidence of emphysema heterogeneity and fissure completeness was associated with an enhanced response to treatment.


CONCLUSIONS
Endobronchial-valve treatment for advanced heterogeneous emphysema induced modest improvements in lung function, exercise tolerance, and symptoms at the cost of more frequent exacerbations of COPD, pneumonia, and hemoptysis after implantation. (Funded by Pulmonx; ClinicalTrials.gov number, NCT00129584.)
Diagnosis of occult scaphoid fractures and other wrist injuries

To examine the efficacy of repeated clinical examinations and follow-up radiographs, 121 patients were prospectively and consecutively randomised and clinically followed until a final diagnosis was achieved. All of these patients additionally underwent magnetic resonance imaging (MRI) scans within an average of 3 days after trauma to control the results of this study. MRI detected 112 injuries in 82 patients (67%). Twenty-eight (25%) of these injuries were scaphoid fractures. There were 15 fractures of other carpal bones, 14 avulsion fractures of extrinsic ligaments (AFL), 26 other bone injuries (fractures of distal radius, fractures of radial styloid, ulnar head fracture metacarpal fracture, bone bruises), and 29 soft tissue injuries (triangular fibro-cartilaginous complex injuries, complete or partial ruptures of the scapholunate ligament, ruptures of the radial collateral ligament, hemarthrosis). By means of repeated clinical examinations and plain scaphoid views, experienced observers were able to detect all the occult scaphoid fractures within 38 days, as well as most of the other fractures about the wrist except one fracture of the triquetrum. Soft tissue injuries, however, were diagnosed only in two cases of complete scapholunate ligament tears. It was further obvious that 70% of all scaphoid fractures and 60% of the AFLs were detected in a review of the initial X-rays by experienced surgeons. Only 30% of all scaphoid fractures detected were really occult and all of these were diagnosed correctly. This prospective study demonstrates that clinical and radiological standard procedures are reliable in the diagnosis of occult fractures of the carpus and wrist when performed by experienced observers. MRI scans are indicated for early diagnosis of occult fractures and soft tissue injuries about the wrist.
Association between scalp hair-whorl direction and hemispheric language dominance

Asymmetry is a common phenomenon in higher organisms. In humans, the cortical representation of language exhibits a high degree of asymmetry with a prevalence of about 90% of left hemispheric dominance, the underlying mechanisms of which are largely unknown. Another sign that exhibits a form of lateralization is the scalp hair-whorl direction, which is either clockwise or anti-clockwise. The scalp hair-whorl develops from the same germ layer as the nervous system, the ectoderm, between the 10th and 16th week in utero and has been shown to be associated with various neurodevelopmental disorders. Here, we use an established fMRI paradigm to examine the association of a solely biological marker of asymmetry, hair-whorl direction and language lateralization. We show that the mechanism that influences hair-whorl direction and handedness [Klar, A.J.S., 2003. Human handedness and scalp hair-whorl direction develop from a common genetic mechanism. Genetics 1651, 269-276.] also affects cerebral language dominance.
Boceprevir in genotype 1 chronic hepatitis C: first experiences in Serbia.

INTRODUCTION
The triple therapy which consists of one of the protease inhibitor plus pegylated interferon and ribavirin (P/R) is the standard of care for the treatment of chronic hepatitis C virus (HCV) genotype 1 (G1) infection both in treatment-naïve and experienced patients.


OBJECTIVE
The aim of this study was to analyze the efficacy and tolerability of this regime in hospital practice in Serbia.


METHODS
From July 2012 to October 2012, 20 previously treated patients with advanced fibrosis and HCV G1 infection were included in the triple antiviral regimen in six referral centers in Serbia. All patients were treated with response guide therapy (RGT) regime according to the boceprevir treatment protocol. During the 4-week lead-in period all patients received peginterferon plus ribavirin. After the lead-in pe- riod boceprevir was added in the dosage of 800 mg three times a day orally.The subsequent treatment varied according to virologic response and fibrosis. During the therapy HCV RNA level was measured at week 4, 8, 12, 24 of the treatment for the assessment of virologic response profile. All patients who completed therapy were assessed at the end of the treatment and at the end of an additional 24-week treatment-free period for a sustained virologic response (SVR).


RESULTS
The total of 20 patients with advanced fibrosis was treated. Among patients with an undetectable HCV RNA level at week 8 the rate of SVR was 100%. No patient with decrease in the HCV RNA level < 1 log 10 IU/ml at treatment week 4 achieved SVR. The overall rate of SVR was 55%. The safety profile of the treatment regimen was good. Anemia was reported in 25% of patients. There was no life-threatening treatment adverse event.


CONCLUSION
Boceprevir in combination with P/R achieved fairly good SVR rates in patients that were"most difficult to treat"who failed on dual therapy and was effective among patients with cirrhosis.
Geostatistical Space-Time Models , Stationarity , Separability , and Full Symmetry

4.
Health effect of the New Nordic Diet in adults with increased waist circumference: a 6-mo randomized controlled trial.

BACKGROUND
The regional Mediterranean Diet has been associated with lower risk of disease.


OBJECTIVE
We tested the health effects of the New Nordic Diet (NND), which is a gastronomically driven regional, organic, and environmentally friendly diet, in a carefully controlled but free-living setting.


DESIGN
A total of 181 centrally obese men and women, with a mean (range) age of 42 y (20-66 y), body mass index (in kg/m(2)) of 30.2 (22.6-47.3), and waist circumference of 100 cm (80-138 cm) were randomly assigned to receive either the NND (high in fruit, vegetables, whole grains, and fish) or an average Danish diet (ADD) for 26 wk. Participants received cookbooks and all foods ad libitum and free of charge by using a shop model. The primary endpoint was the weight change analyzed by both completer and intention-to-treat analyses.


RESULTS
A total of 147 subjects [81% (NND 81%; ADD 82%)] completed the intervention. A high dietary compliance was achieved, with significant differences in dietary intakes between groups. The mean (±SEM) weight change was -4.7 ± 0.5 kg for the NND compared with -1.5 ± 0.5 kg for the ADD (adjusted difference: -3.2 kg; 95% CI: -4.6, -1.8 kg; P < 0.001) for the completer analysis, and the difference was -3.0 kg (95% CI: -4.0, -2.1 kg) for the intention-to-treat analysis. The NND produced greater reductions in systolic blood pressure (adjusted difference: -5.1 mm Hg; 95% CI: -8.2, -2.1 mm Hg) and diastolic blood pressure (adjusted difference: -3.2 mm Hg; 95% CI: -5.7, -0.8 mm Hg) than did the ADD.


CONCLUSION
An ad libitum NND produces weight loss and blood pressure reduction in centrally obese individuals. This trial was registered at www.clinicaltrials.gov as NCT01195610.
A novel role for the anti-senescence factor TBX2 in DNA repair and cisplatin resistance

The emergence of drug resistant tumours that are able to escape cell death pose a major problem in the treatment of cancers. Tumours develop resistance to DNA-damaging chemotherapeutic agents by acquiring the ability to repair their DNA. Combination therapies that induce DNA damage and disrupt the DNA damage repair process may therefore prove to be more effective against such tumours. The developmentally important transcription factor TBX2 has been suggested as a novel anticancer drug target, as it is overexpressed in several cancers and possesses strong anti-senescence and pro-proliferative functions. Importantly, we recently showed that when TBX2 is silenced, we are able to reverse several features of transformation in both breast cancer and melanoma cells. Overexpression of TBX2 has also been linked to drug resistance and we have shown that its ectopic expression results in genetically unstable polyploidy cells with resistance to cisplatin. Whether the overexpression of endogenous TBX2 levels is associated with cisplatin resistance in TBX2-driven cancers has, however, not been shown. To address this we have silenced TBX2 in a cisplatin-resistant breast cancer cell line and we show that knocking down TBX2 sensitises the cells to cisplatin by disrupting the ATM-CHK2-p53 signalling pathway. Cell cycle analyses demonstrate that when TBX2 is knocked down there is an abrogation of an S-phase arrest but a robust G2/M arrest that correlates with a reduction in phosphorylated CHK2 and p53 levels. This prevents DNA repair resulting in TBX2-deficient cells entering mitosis with damaged DNA and consequently undergoing mitotic catastrophe. These results suggest that targeting TBX2 in combination with chemotherapeutic drugs such as cisplatin could improve the efficacy of current anticancer treatments.
Repeated retrieval during learning is the key to long-term retention q

Tests not only measure the contents of memory, they can also enhance learning and long-term retention. We report two experiments inspired by Tulving’s (1967) pioneering work on the effects of testing on multitrial free recall. Subjects learned lists of words across multiple study and test trials and took a final recall test 1 week after learning. In Experiment 1, repeated testing during learning enhanced retention relative to repeated studying, although alternating study and test trials produced the best retention. In Experiment 2, recalled items were dropped from further studying or further testing to investigate how different types of practice affect retention. Repeated study of previously recalled items did not benefit retention relative to dropping those items from further study. However, repeated recall of previously recalled items enhanced retention by more than 100% relative to dropping those items from further testing. Repeated retrieval of information is the key to long-term retention. 2006 Elsevier Inc. All rights reserved.
The relationship among computer work, environmental design, and musculoskeletal and visual discomfort: examining the moderating role of supervisory relations and co-worker support.

PURPOSE
The prevalence of work-related upper extremity musculoskeletal disorders and visual symptoms reported in the USA has increased dramatically during the past two decades. This study examined the factors of computer use, workspace design, psychosocial factors, and organizational ergonomics resources on musculoskeletal and visual discomfort and their impact on the safety and health of computer work employees.


METHODS
A large-scale, cross-sectional survey was administered to a US manufacturing company to investigate these relationships (n = 1259). Associations between these study variables were tested along with moderating effects framed within a conceptual model.


RESULTS
Significant relationships were found between computer use and psychosocial factors of co-worker support and supervisory relations with visual and musculoskeletal discomfort. Co-worker support was found to be significantly related to reports of eyestrain, headaches, and musculoskeletal discomfort. Supervisor relations partially moderated the relationship between workspace design satisfaction and visual and musculoskeletal discomfort.


CONCLUSION
This study provides guidance for developing systematic, preventive measures and recommendations in designing office ergonomics interventions with the goal of reducing musculoskeletal and visual discomfort while enhancing office and computer workers' performance and safety.
Meditation therapies for attention-deficit/hyperactivity disorder (ADHD).

BACKGROUND
Attention-deficit/hyperactivity disorder (ADHD) is one of the most common developmental disorders experienced in childhood and can persist into adulthood. The disorder has early onset and is characterized by a combination of overactive, poorly modulated behavior with marked inattention. In the long term it can impair academic performance, vocational success and social-emotional development. Meditation is increasingly used for psychological conditions and could be used as a tool for attentional training in the ADHD population.


OBJECTIVES
To assess the effectiveness of meditation therapies as a treatment for ADHD.


SEARCH STRATEGY
Our extensive search included: CENTRAL, MEDLINE, EMBASE, CINAHL, ERIC, PsycINFO, C2-SPECTR, dissertation abstracts, LILACS, Virtual Health Library (VHL) in BIREME, Complementary and Alternative Medicine specific databases, HSTAT, Informit, JST, Thai Psychiatric databases and ISI Proceedings, plus grey literature and trial registries from inception to January 2010.


SELECTION CRITERIA
Randomized controlled trials that investigated the efficacy of meditation therapy in children or adults diagnosed with ADHD.


DATA COLLECTION AND ANALYSIS
Two authors extracted data independently using a pre-designed data extraction form. We contacted study authors for additional information required. We analyzed data using mean difference (MD) to calculate the treatment effect. The results are presented in tables, figures and narrative form.


MAIN RESULTS
Four studies, including 83 participants, are included in this review. Two studies used mantra meditation while the other two used yoga compared with drugs, relaxation training, non-specific exercises and standard treatment control. Design limitations caused high risk of bias across the studies. Only one out of four studies provided data appropriate for analysis. For this study there was no statistically significant difference between the meditation therapy group and the drug therapy group on the teacher rating ADHD scale (MD -2.72, 95% CI -8.49 to 3.05, 15 patients). Likewise, there was no statistically significant difference between the meditation therapy group and the standard therapy group on the teacher rating ADHD scale (MD -0.52, 95% CI -5.88 to 4.84, 17 patients). There was also no statistically significant difference between the meditation therapy group and the standard therapy group in the distraction test (MD -8.34, 95% CI -107.05 to 90.37, 17 patients).


AUTHORS' CONCLUSIONS
As a result of the limited number of included studies, the small sample sizes and the high risk of bias, we are unable to draw any conclusions regarding the effectiveness of meditation therapy for ADHD. The adverse effects of meditation have not been reported. More trials are needed.
A novel OTA with dual bulk-driven input stage

A novel operational transconductance amplifier with dual bulk-driven input stage is introduced, suitable for portable biomedical monitoring system and battery-operated devices. The scheme not only avoids the leakage current of conventional bulk-driven circuit but also reduces power consumption. Based on the proposed topology, a low voltage, low power OTA with rail-to-rail input common-mode range and constant small signal behavior is achieved. The simulated power consumption of the OTA is only 9.9uW utilizing a 0.9V supply voltage in TSMC 0.35µm CMOS technology.
Immediate versus delayed quitting and rates of relapse among smokers treated successfully with varenicline, bupropion SR or placebo

AIMS
We assessed to what degree smokers who fail to quit on the target quit date (TQD) or lapse following TQD eventually achieve success with continued treatment.


DESIGN
A secondary analysis of pooled data of successful quitters treated with varenicline (306 of 696), bupropion (199 of 671) and placebo (121 of 685) from two identically-designed clinical trials of varenicline versus bupropion sustained-release and placebo.


SETTING
Multiple research centers in the US.


PARTICIPANTS
Adult smokers (n==2052) randomized to 12 weeks drug treatment plus 40 weeks follow-up.


MEASUREMENT
The primary end-point for the trials was continuous abstinence for weeks 9-12. TQD was day 8. Two patterns of successful quitting were identified. Immediate quitters (IQs) were continuously abstinent for weeks 2-12. Delayed quitters (DQs) smoked during 1 or more weeks for weeks 2-8.


FINDINGS
Cumulative continuous abstinence (IQs + DQs) increased for all treatments during weeks 3-8. Overall IQs and DQs for varenicline were (24%; 20%) versus bupropion (18.0%, P=0.007; 11.6%, P<0.001) or placebo (10.2%, P<0.001; 7.5%, P<0.001). However, DQs as a proportion of successful quitters was similar for all treatments (varenicline 45%; bupropion 39%; placebo 42%) and accounted for approximately one-third of those remaining continuously abstinent for weeks 9-52. No gender differences were observed by quit pattern. Post-treatment relapse was similar across groups.


CONCLUSIONS
Our data support continuing cessation treatments without interruption for smokers motivated to remain in the quitting process despite lack of success early in the treatment.