LLukas22/scidocs huggingface dataset:
Periodic Performance Prediction for Real-time Business Process Monitoring

Purpose – The purpose of this paper is to provide industrial managers with insight into the real-time progress of running processes. The authors formulated a periodic performance prediction algorithm for use in a proposed novel approach to real-time business process monitoring. Design/methodology/approach – In the course of process executions, the final performance is predicted probabilistically based on partial information. Imputation method is used to generate probable progresses of ongoing process and Support Vector Machine classifies the performances of them. These procedures are periodically iterated along with the real-time progress in order to describe the ongoing status. Findings – The proposed approach can describe the ongoing status as the probability that the process will be executed continually and terminated as the identical result. Furthermore, before the actual occurrence, a proactive warning can be provided for implicit notification of eventualities if the probability of occurrence of the given outcome exceeds the threshold. Research limitations/implications – The performance of the proactive warning strategy was evaluated only for accuracy and proactiveness. However, the process will be improved by additionally considering opportunity costs and benefits from actual termination types and their warning errors. Originality/value – Whereas the conventional monitoring approaches only classify the already occurred result of a terminated instance deterministically, the proposed approach predicts the possible results of an ongoing instance probabilistically over entire monitoring periods. As such, the proposed approach can provide the real-time indicator describing the current capability of ongoing process.
A first-in-human dose-escalation study of ME-143, a second generation NADH oxidase inhibitor, in patients with advanced solid tumors

Background ME-143, a second-generation tumor-specific NADH oxidase inhibitor, is broadly active against human cancers in vitro and in vivo. This first-in-human dose-escalation study evaluated the dose-limiting toxicities (DLTs), pharmacokinetics, safety, tolerability, and preliminary anti-tumor activity of ME-143 in patients with advanced solid tumors. Methods Patients with advanced solid tumors were treated in a 3 + 3 escalation design. ME-143 was administered via intravenous infusion on days 1, 8, and 15 of the first 28-day cycle, and weekly thereafter; the final cohort received twice-weekly treatment. Samples for pharmacokinetic analysis were collected during cycle 1. Treatment continued until disease progression or unacceptable toxicity. Results Eighteen patients were treated: 2.5 mg/kg (n = 3); 5 mg/kg (n = 3); 10 mg/kg (n = 3); 20 mg/kg (n = 6); 20 mg/kg twice-weekly (n = 3). There were no DLTs observed. Nearly all treatment-related toxicities were grade 1/2, specifically (all grades) nausea (22 %) and fatigue (17 %). Two patients experienced infusion reactions at the 20 mg/kg dose level, one of which was grade 4. Stable disease was documented in three patients with colorectal cancer, cholangiocarcinoma, and anal cancer. Pharmacokinetic exposures were linear and dose-dependent, with a half-life of approximately 5 h. Conclusions ME-143 was well-tolerated when administered intravenously at the maximally administered/recommended phase 2 dose of 20 mg/kg once weekly to patients with advanced solid tumors. Though limited clinical activity was observed with monotherapy, inhibitors of tumor-specific NADH oxidase such as ME-143 may derive their greatest benefit in combination with cytotoxic chemotherapy.
A method for registration of single photon emission computed tomography (SPECT) and computed tomography (CT) images for liver stereotactic radiotherapy (SRT).

PURPOSE
To describe a simple method of coregistration of nonanatomic liver SPECT and CT images acquired in separate sessions for three-dimensional (3D)-CRT planning utilizing dual radiolabeled and radiopaque body surface markers, and evaluate the accuracy of the registration on the patient surface.


METHODS
Ten patients treated for liver metastases or hepatocellular carcinoma with stereotactic body radiation therapy or 3D-CRT were selected for this study to evaluate the SPECT∕CT registration process. All patients were positioned in a custom-molded vacuum bag on the flat table top. Nine radiopaque markers were taped to the abdominal surface in three axial planes at the level of the liver. Following CT imaging, the nine radiopaque markers were then labeled with radioactive tags, each containing 10 μCi of (99m)Tc, and SPECT images were acquired. The metric used to evaluate the registration was the fiducial registration error (FRE), defined as the root mean square of the distance between pairs of homologous markers on the CT and SPECT images. The evaluation of the registration accuracy was performed in two steps: first the minimum number of markers necessary to obtain a robust registration was optimized; second the FRE was calculated on the remaining set of unused markers. Additionally, the deformation of the patient's abdominal surface between CT and SPECT acquisition sessions was evaluated using the distances between all possible unused marker pairs on the CT and SPECT images separately. The root mean square of the CT-to-SPECT difference between those distances was used to define the deformation index (DI). The registration method was evaluated on all ten patients in addition to an anthropomorphic phantom study.


RESULTS
The minimum number of markers above which the registration was not improved by more than 1 mm was 4. The FRE, calculated over the 5 remaining markers, was 6.1 mm for the patient population and 1.8 mm for the phantom study. The DI was 5.0 mm on average over all 10 patients and correlated well with the FRE. The DI was 1.6 mm for the phantom study, which represented the imaging systems' resolution and the ability to place the CT and SPECT markers at the exact same location.


CONCLUSIONS
It is feasible to use radiolabeled and radiopaque dual body surface markers for registration of SPECT and CT images acquired in separate sessions allowing conformal avoidance of SPECT-defined functional normal liver. Point-based rigid registration accuracy on the patient surface of 6.1 mm can be achieved using 4 dual body surface markers. The main contribution to the registration error is the deformation of the abdominal surface, arising from the inability to setup the patient in the exact same position at different times on two different imaging systems, and to properly account for breathing artifacts on the CT and SPECT images.
A Block Cipher Generation Using Color Substitution

The most powerful and common approach to countering the threats to network / information security is encryption [1]. Even though it is very powerful, the cryptanalysts are very intelligent and they were working day and night to break the ciphers. To make a stronger cipher it is recommended that to use: More stronger and complicated encryption algorithms, Keys with more number of bits (Longer keys), larger block size as input to process, use authentication and confidentiality and secure transmission of keys. It is for sure that if we follow all the mentioned principles we can make a very stronger cipher. With this we have the following problems: It is a time consuming process for both encryption and decryption, It is difficult for the crypt analyzer to analyze the problem. Also suffers with the problems in the existing system. The main objective of this paper is to solve all these problems and to bring the revolution in the Network security with a new substitution technique [3] is ‘color substitution technique’ and named as a “Play color cipher”.
Automatic make and model recognition from frontal images of cars

We investigate a range of solutions in car ‘make and model’ recognition. Several different feature detection approaches are investigated and applied to the problem including a new approach based on Harris corner strengths. This approach recursively partitions the image into quadrants, the feature strengths in these quadrants are then summed and locally normalised in a recursive, hierarchical fashion. Two different classification approaches are investigated; a k-nearest-neighbour classifier and a Naive Bayes classifier. Our system is able to classify vehicles with 96.0% accuracy, tested using leave-one-out cross-validation on a realistic dataset of 262 frontal images of cars.
Programming Online Judge System

With the development of online education, the pattern of education which based on the Internet obtained the general recognition of the society. People prefer to learn and share the open courses on the Internet in universities or colleges all over the world. However, the courses opened online can support the massive peoples to learn online, but couldn't support they to program on the network, and judge the program on the network. In order to support more and more students to complete the experiments of the online courses, automatic judging system about software experiments and hardware experiments are needed to develop to ensure the correctness of the design of experiments. The Background Evaluation System is in MOOC (massive online open courses) environment, it can connect different experiment systems to finish different courses. It also can simulate the hardware experiments online and test hardware experiments automatically. Programming online judge system, mentioned in this paper, can solve much of the problems. With the help of Programming online judge system, different universities can share their resources and save investment. Users can look up for the information conveniently and get experience similar to local experiment.
Abbreviated infusion of eptifibatide after successful coronary intervention The BRIEF-PCI (Brief Infusion of Eptifibatide Following Percutaneous Coronary Intervention) randomized trial.

OBJECTIVES
The purpose of this study was to assess whether the early discontinuation of eptifibatide infusion in nonemergent percutaneous coronary intervention (PCI) is associated with a higher frequency of periprocedural ischemic myonecrosis.


BACKGROUND
The recommended regimen for eptifibatide is a double bolus followed by an infusion for 18 h. It is not known whether the infusion can be shortened if the PCI is uncomplicated.


METHODS
We enrolled 624 patients with stable angina, acute coronary syndrome, or recent ST-segment elevation myocardial infarction (>48 h) who underwent successful coronary stenting and received eptifibatide. Patients were randomly assigned to receive either an 18-h infusion or an abbreviated infusion of <2 h. The primary end point was the incidence of periprocedural myonecrosis defined as troponin-I elevation >0.26 microg/l. Secondary end points included death, myocardial infarction, urgent target vessel revascularization at 30 days, and in-hospital major bleeding using the REPLACE-2 (Randomized Evaluation in PCI Linking Angiomax to Reduced Clinical Events) trial criteria.


RESULTS
The incidence of periprocedural myonecrosis was 30.1% in the <2-h group versus 28.3% in the 18-h group (mean difference: 1.8%; upper bound of 95% confidence interval: 7.8%; p < 0.012 for noninferiority). The 30-day incidence of myocardial infarction, death, and target vessel revascularization was similar in both groups (p = NS). Major bleeding was less frequent in the <2-h group (1.0% vs. 4.2%, p = 0.02).


CONCLUSIONS
After uncomplicated PCI, eptifibatide infusion can be abbreviated safely to <2 h. It is not inferior to the standard 18-h infusion in preventing ischemic outcome, and it may be associated with less major bleeding. (Brief Infusion of Eptifibatide Following Percutaneous Coronary Intervention [BRIEF PCI]; NCT00111566).
The sustainability syndicate: Shared responsibility in a trans-organizational business model

Abstract This paper proposes design principles for the ‘sustainability syndicate’: shared responsibility among diverse stakeholders for sustainability; an agenda for unifying economic and ethical rationales; and plural governance based primarily on markets, contracts and collaborative relationships. The paper suggests a research agenda directed at issues that constrain sustainability syndicates. Syndication's contributions to sustainability build upon its trans-organizational structures for shared responsibility. Syndication works as an insurance cooperative that reduces the financial burden of risk. In addition, members could rent skill sets from other stakeholders, reduce barriers to entry into bigger projects, and improve efficiencies. As underlying sustainability are both economic and ethical rationales for shared responsibility, sustainability syndicates induct diverse non-commercial stakeholders into inclusive settings. A unifying agenda in these settings, as it grapples with externalities and constructs welfare-enhancing solutions, enhances sustainability brand differentiation. Plural self-governance, as it corrects for failures of individual self-governance modes, enables market making and market access, reduces transaction costs in contracting, and enables members to build the trust and commitment necessary for collaborations. Sustainability syndicates obviate the need for command-and-control interventions. Although institutional, performance and instrumental constraints still remain, syndicate business models offer potentially game-changing strategies in sustainability marketing.
High-temperature kinetics study of 430L steel powder oxidized in air at 600–850 °C

Abstract The 430L stainless steel powder with a mean particle size of 95 μm was studied to determine its high-temperature oxidation properties. Continuous thermogravimetric measurements were carried out for 100 h in air at temperatures in the range of 600–850 °C. Even though a considerable amount of Cr (up to ˜5 wt.% Cr) inside the grains was depleted – especially inside small grains – no breakaway oxidation was observed. This indicates that both the remaining Cr and the formed chromia scale remained protective with regard to the metallic core until the Cr concentration reached very low levels.
Impact of providing booklets about chemotherapy to newly presenting patients with cancer: a randomized controlled trial.

BACKGROUND
There has been limited research examining the efficacy of providing written information to cancer patients in southern and eastern European countries. This study investigated the impact of a booklet about chemotherapy on patient satisfaction, quality of life (QoL) and emotional distress, and assessed booklet use.


PATIENTS AND METHODS
A total of 145 Greek cancer outpatients prior to commencing chemotherapy completed a questionnaire and were randomized to receive (n = 72) or not receive (n = 73) the booklet. All patients completed the second questionnaire before the following cycle of chemotherapy.


RESULTS
Baseline characteristics were well balanced between the two groups. Experimental group patients reported being significantly more satisfied with the information received and care overall than those in the control group, felt significantly more and better informed, and perceived the information received as being clearer and detailed. The intervention produced no benefits in terms of anxiety, depression or QoL. The booklet was read by almost all patients and to a great extent by significant others. The majority considered the booklet useful to read and helpful in recalling chemotherapy-related information.


CONCLUSIONS
The current results provide further evidence on the efficacy of information-giving interventions in societies where disclosure of information to cancer patients still remains controversial.
A Self-Healing, Self-Protecting Collaborative Intrusion Detection Architecture to Trace-Back Fast-Flux Phishing Domains

Millions of users divulge their personal information on phishing web sites, which causes over a billion dollars loss every year. Phishing domain take-down is the most promising approach to address this security issue, since there will be nothing there for a misled user to see if the fraudulent website has been removed completely. A key part of the take-down procedure is phishing hosting system trace-back. Traditional phishing hosting machines can be identified relatively quickly by their public DNS name or directly if their IP address is embedded within spam email. However, a newer architectural innovation known as fast-flux networks uses a pool of compromised machines to hide the phishing website hosting system, which makes phishing website trace-back almost impractical. We propose a decentralized collaborative intrusion detection approach to address this defense challenge, which is based on a collaborative intrusion detection system (CIDS) architecture. The participating detection systems are from different ISPs, which allows the fast-flux machines to be monitored. The suspicious communication pattern of fast- flux machines are correlated across different ISPs in a multistage manner, to trace-back the actual phishing website hosting machine. The architecture is scalable and self-healing through its use of a structured peer-to-peer network, and also enables the participants to be self-protecting. The communication is loosely coupled by a publish/subscribe mechanism. Our evaluation results show that our proposed decentralized CIDS is more effective than a fully centralized system.
Circulating atrial natriuretic peptide genetic association study identifies a novel gene cluster associated with stroke in whites.

BACKGROUND
The goal of this study was to identify genetic determinants of plasma N-terminal proatrial natriuretic peptide (NT-proANP) in the general community by performing a large-scale genetic association study and to assess its functional significance in in vitro cell studies and on disease susceptibility.


METHODS AND RESULTS
Genotyping was performed across 16 000 genes in 893 randomly selected individuals, with replication in 891 subjects from the community. Plasma NT-proANP1-98 concentrations were determined using a radioimmunoassay. Thirty-three genome-wide significant single-nucleotide polymorphisms were identified in the MTHFR-CLCN6-NPPA-NPPB locus and were all replicated. To assess the significance, in vitro functional genomic studies and clinical outcomes for carriers of a single-nucleotide polymorphism rs5063 (V32M) located in NPPA that represented the most significant variation in this genetic locus were assessed. The rs5063 variant allozyme in transfected HEK293 cells was decreased to 55±8% of wild-type protein (P=0.01) as assessed by quantitative western blots. Carriers of rs5063 had lower NT-proANP levels (1427 versus 2291 pmol/L; P<0.001) and higher diastolic blood pressures (75 versus 73 mm Hg; P=0.009) and were at an increased risk of stroke when compared with wild-type subjects independent of age, sex, diabetes mellitus, hypertension, atrial fibrillation, and cholesterol levels (hazard ratio, 1.6; P=0.004).


CONCLUSIONS
This is the first large-scale genetic association study of circulating NT-proANP levels performed with replication and functional assessment that identified genetic variants in the MTHFR-CLCN6-NPPA-NPPB cluster to be significantly associated with NT-proANP levels. The clinical significance of this variation is related to lower NT-proANP levels, higher blood pressures, and an increased risk of stroke in the general community.
Duality theorems and algorithms for linear programming in measure spaces

The purpose of this paper is to present some results on linear programming in measure spaces (LPM). We prove that, under certain conditions, the optimal value of an LPM is equal to the optimal value of the dual problem (DLPM). We also present two algorithms for solving various LPM problems and prove the convergence properties of these algorithms.
Determinants of adoption and productivity of improved rice varieties in southwestern Nigeria

The study examines the status of adoption of improved rice varieties and its impact on rice production among smallholder farmers in southwestern Nigeria. Data for this study were generated from a farm survey of rice farmers selected by multi-stage sampling technique in two of the rice producing states of the region. The study employed adoption index, logit model and stochastic frontier model to assess the adoption status, its determinants and impact on farmers’ productivity respectively. The results show that farmers have responded appreciably to intervention programme that promote the use of improved rice varieties with an adoption rate of 68.7% which has resulted in an estimated proportional production increase of 19.4%. The mean yield of improved rice varieties (1.601 tons/ha) was significantly higher than the yield of the local varieties (1.154 tons/ha) with a yield advantage of 38.7%. In addition, rice yield for adopters of improved rice varieties (1.90 tons/ha) was significantly higher than that of non adopters (1.07 tons/ha). However, land area cultivated to rice, frequency of extension contact and the yield rating of the improved rice varieties were significant determinants of farmers’ decision to adopt improved rice varieties while with an average technical efficiency score of 78.4%, rice farmers have room to increase their productivity by increasing their farm size, quantity of improved seed and fertilizer.
Well-being and problematic Facebook use

Social networking sites are getting more widespread online communication forms all over the world. Especially adolescents and emerging adults use these sites to make connection, and share something. Although, Facebook is one of the most popular sites, research is still in nascent phase on the excessive use of Facebook. Hence, it is fundamental to determine potential predictors of overuse of Facebook. The present study investigated the relationship between well-being and problematic Facebook use. Participants were 311 university students [179(58%) female, 132(42%) male, Mage = 20.86 years, SD = 1.61] who completed the questionnaire packet including the Bergen Facebook Addiction Scale (Andreassen, Torsheim, Brunborg, & Pallesen, 2012), the Satisfaction with Life Scale (Diener, Emmons, Larsen, & Griffin, 1985), the Subjective Vitality Scale (Ryan & Frederick, 1997), the Flourishing Scale (Diener et al., 2010), and the Subjective Happiness Scale (Lyubomirsky & Lepper, 1999). A stepwise regression analyses was used with four independent variables (life satisfaction, subjective vitality, flourishing, and subjective happiness) to explain variance in problematic Facebook use. The results showed that life satisfaction, subjective vitality, flourishing, and subjective happiness were significant negative predictors of problematic Facebook use. The significance and limitations of the results are discussed. 2015 Published by Elsevier Ltd.