LLukas22/scidocs huggingface dataset:
Vitis vinifera (Muscat Variety) Seed Ethanolic Extract Preserves Activity Levels of Enzymes and Histology of the Liver in Adult Male Rats with Diabetes

The effect of V. vinifera seeds on carbohydrate metabolizing enzymes and other enzymes of the liver in diabetes is currently unknown. We therefore investigated changes in the activity levels of these enzymes following V. vinifera seed extract administration to diabetic rats. Methods. V. vinifera seed ethanolic extract (250 and 500 mg/kg/day) or glibenclamide (600 μg/kg/day) was administered to streptozotocin-induced male diabetic rats for 28 consecutive days. At the end of treatment, liver was harvested and activity levels of various liver enzymes were determined. Levels of thiobarbituric acid reactive substances (TBARS) were measured in liver homogenates and liver histopathological changes were observed. Results. V. vinifera seed ethanolic extract was able to prevent the decrease in ICDH, SDH, MDH, and G-6-PDH and the increase in LDH activity levels in liver homogenates. The seed extract also caused serum levels of ALT, AST, ALP, ACP, GGT, and total bilirubin to decrease while causing total proteins to increase. Additionally, the levels of ALT, AST, and TBARS in liver homogenates were decreased. Histopathological changes in the liver were reduced. Conclusion. Near normal activity levels of various enzymes and histology of the liver following V. vinifera seed ethanolic extract administration may be due to decrease in liver oxidative stress in diabetes.
Popularity Dynamics and Intrinsic Quality in Reddit and Hacker News

In this paper we seek to understand the relationship between the online popularity of an article and its intrinsic quality. Prior experimental work suggests that the relationship between quality and popularity can be very distorted due to factors like social influence bias and inequality in visibility. We conduct a study of popularity on two different social news aggregators, Reddit and Hacker News. We define quality as the number of votes an article would have received if each article was shown, in a bias-free way, to an equal number of users. We propose a simple Poisson regression method to estimate this quality metric from time-series voting data. We validate our methods on data from Reddit and Hacker News, as well the experimental data from prior work. Using these estimates, we find that popularity on Reddit and Hacker News is a relatively strong reflection of intrinsic quality.
Consistent Individualized Feature Attribution for Tree Ensembles

Interpreting predictions from tree ensemble methods such as gradient boosting machines and random forests is important, yet feature attribution for trees is often heuristic and not individualized for each prediction. Here we show that popular feature attribution methods are inconsistent, meaning they can lower a feature’s assigned importance when the true impact of that feature actually increases. This is a fundamental problem that casts doubt on any comparison between features. To address it we turn to recent applications of game theory and develop fast exact tree solutions for SHAP (SHapley Additive exPlanation) values, which are the unique consistent and locally accurate attribution values. We then extend SHAP values to interaction effects and define SHAP interaction values. We propose a rich visualization of individualized feature attributions that improves over classic attribution summaries and partial dependence plots, and a unique “supervised” clustering (clustering based on feature attributions). We demonstrate better agreement with human intuition through a user study, exponential improvements in run time, improved clustering performance, and better identification of influential features. An implementation of our algorithm has also been merged into XGBoost and LightGBM, see http://github.com/slundberg/shap for details. ACM Reference Format: Scott M. Lundberg, Gabriel G. Erion, and Su-In Lee. 2018. Consistent Individualized Feature Attribution for Tree Ensembles. In Proceedings of ACM (KDD’18). ACM, New York, NY, USA, 9 pages. https://doi.org/none
Expanding the scope of health information systems. Challenges and developments.

OBJECTIVES
To identify current challenges and developments in health information systems.


METHODS
Reports on HIS, eHealth and process support were analyzed, core problems and challenges were identified.


RESULTS AND CONCLUSION
Health information systems are extending their scope towards regional networks and health IT infrastructures. Integration, interoperability and interaction design are still today's core problems. Additional problems arise through the integration of genetic information into the health care process. There are noticeable trends towards solutions for these problems.
Capecitabine plus gemcitabine in thymic epithelial tumors: final analysis of a Phase II trial.

BACKGROUND
A multi-institutional Phase II trial was initiated in 2005 to test the combination gemcitabine and capecitabine in patients with thymic epithelial malignancies (TETs).


PATIENTS & METHODS
Patients with histologic confirmation of TET diagnosis by central review who had received >1 systemic chemotherapy treatment were included. Patients received oral capecitabine (650 mg/mq twice daily on days 1-14) and intravenous gemcitabine (1000 mg/mq on days 1 and 8 every 3 weeks).


RESULTS
Of the 30 patients included (18 men, 12 women; median age: 57 years, range: 48-61 years), the majority (73%) had thymoma, and the remaining thymic carcinoma. Eight patients developed grade 3-4 neutropenia. A total of 12 patients had a response. Median progression-free survival was 11 months (range: 6.5-16.5).


CONCLUSION
Capecitabine and gemcitabine is highly active in TETs.
Online Estimation of the Approximate Posterior Cramer-Rao Lower Bound for Discrete-Time Nonlinear Filtering

Although it is difficult to assess the achievable performance of nonlinear tracking applications, it nevertheless remains extremely important to do so. This paper illustrates how the mean and covariance of the estimated online state can be used to recursively calculate an approximate posterior Cramer-Rao lower bound (CRLB). Most CRLB implementations require the true state, but this is impractical except for appropriately designed experiments or simulations where the exact value of the state is given as prior knowledge. The performance of the approximate posterior CRLB (PCRLB) used in conjunction with the extended Kalman filter (EKF) and the unscented Kalman filter (UKF) for online state estimation are investigated. To test the validity of the proposed method, it was applied to the problem of tracking a ballistic object on reentry. Simulation results confirm the theory and reveal that the proposed approximate PCRLB is sufficiently accurate and that the PCRLB approximations obtained using different state filters are in general very close to each other.
Effects of accelerated repetitive impulse voltage aging on performance of model stator insulation of wind turbine generator

A high reliability is essential for the insulation system of wind turbine generator because of its high repairing cost. In this paper, three experimental methods based on accelerated aging under repetitive impulse voltage and multi-environmental factors are established to (i) investigate the failure or degradation mechanism during the aging, and (ii) make recommendations on how to assess the functional life and reliability of insulation systems for wind turbine generator. Repetitive impulse voltage stress combined with thermal stress, change of temperature, steady damp heat and salt mist was, in turn, applied to model specimens with different length and section sizes. Some of non-destructive characteristic parameters such as dissipation factor, insulation resistance, and partial discharge inception voltage were measured periodically during the aging. In addition to the residual breakdown voltage, the appearance features and infrared spectrum analysis of specimens were carried out after aging. It has been found that the surface partial discharge generated under repetitive impulse voltage resulted in the degradation of surface insulating material near the slot end. The change of temperature also caused the delaminating of stator insulation from the core slot especially when massimpregnated insulation used in long slot of practical stator. The increase of dissipation factor of insulation system was largely contributed by salt mist and moisture factors especially when the surface or interface of insulation material was damaged. The electrically accelerated aging under about triple maximum repetitive impulse voltage for 1000 h was an effective and feasible method to assess the insulation system of wind turbine generator.
Myocardial dysfunction in neonatal sepsis: a tissue Doppler imaging study.

OBJECTIVES
To assess myocardial performance in septic full-term infants and to correlate it with serum cardiac troponin T concentrations.


DESIGN
Prospective, case-control, clinical study.


SETTING
Neonatal intensive care unit in a university hospital.


PATIENTS
Twenty septic and 20 nonseptic full-term neonates.


INTERVENTIONS
None.


MEASUREMENTS AND MAIN RESULTS
Conventional echocardiography, tissue Doppler imaging, and serum cardiac troponin T concentration tests were performed as soon as diagnosis was made. On tissue Doppler imaging measurements, right ventricular and left ventricular Tei indexes were significantly higher in septic neonates compared to nonseptic neonates (mean ± SD: 0.51 ± 0.09 vs. 0.28 ± 0.05, p < .001, and 0.56 ± 0.07 vs. 0.39 ± 0.04, p < .001, respectively). Mitral and tricuspid peak annular systolic velocities were significantly lower in septic neonates (mean ± SD: 4.35 ± 0.68 vs. 6.89 ± 0.94 cm/sec, p < .0001, and 5.55 ± 0.66 vs. 6.69 ± 0.87 cm/second, p < .0001, respectively). On conventional echocardiography measurements, left ventricular internal diameter at end-diastole was significantly higher in septic neonates (p = .04), whereas cardiac index and left ventricular and right ventricular diastolic functions were not significantly different between septic and nonseptic neonates. Cardiac troponin T concentrations were significantly higher in septic neonates (median [range], 0.19 [0.12- 0.32] vs. 0.03 [0-0.07] mg/L, p < .0001), and they correlated positively with left ventricular Tei index (r = .80; p < .0001) and right ventricular Tei index (r = .73; p < .0001), and correlated negatively with mitral peak annular systolic velocity (r = -.70; p < .0001) and tricuspid peak annular systolic (r = -.39, p = .012). Nonsurvivors had significantly higher serum cardiac troponin T concentrations and left ventricular Tei index.


CONCLUSIONS
Neonatal sepsis is associated with systolic and diastolic myocardial dysfunction. This study provides proof-of-concept data for the use of tissue Doppler imaging in assessment of myocardial dysfunction in septic neonates. Tissue Doppler imaging appears to be more sensitive than conventional echocardiography in the detection of this dysfunction. Serum cardiac troponin T and left ventricular Tei index may have prognostic value in these patients.
Application of reinforcement learning to the game of Othello

Operations research and management science are often confronted with sequential decision making problems with large state spaces. Standard methods that are used for solving such complex problems are associated with some difficulties. As we discuss in this article, these methods are plagued by the so-called curse of dimensionality and the curse of modelling. In this article, we discuss reinforcement learning, a machine learning technique for solving sequential decision making problems with large state spaces. We describe how reinforcement learning can be combined with a function approximation method to avoid both the curse of dimensionality and the curse of modelling. To illustrate the usefulness of this approach, we apply it to a problem with a huge state space—learning to play the game of Othello. We describe experiments in which reinforcement learning agents learn to play the game of Othello without the use of any knowledge provided by human experts. It turns out that the reinforcement learning agents learn to play the game of Othello better than players that use basic strategies. 2006 Elsevier Ltd. All rights reserved.
Noble and alkali adatoms on a [Formula: see text]-Ag surface: a first-principles study.

Using first-principles calculations, we present a comprehensive study on the atomic and electronic structures of metal adatoms (noble metals Ag, Au, Cu and alkali metals Li, Na, K) adsorbed on a [Formula: see text]-Ag (hereafter [Formula: see text]-Ag) surface. We found that adsorption of noble and alkali adatoms can induce significant structural changes in the topmost Ag layer. The most striking and interesting results are the immersion of the noble and Li adatoms into the substrate Ag layer and the finding of the most stable configurations with three adatoms incorporating into or being adsorbed on the surface dependent on their atomic radii. We also found that the almost empty two-dimensional free-electron-like band s1 and its band folding s1(*) of the original surface band s1 of the [Formula: see text]-Ag surface split into a gap at the surface Brillouin zone (SBZ) boundary with adsorption of an adatom. The two surface bands gradually move downwards and the s1 band is gradually filled with an increase of coverage. The s1 band is fully occupied with the largest band gap ∼ 0.25 eV between the s1 and s1(*) bands at the critical coverage of 0.14 monolayers (ML) [three adatoms in a [Formula: see text]-Ag (hereafter [Formula: see text]-Ag) unit cell], which corresponds to the most stable adsorption phase. Although the adsorption configurations are different, both the noble and alkali adatom adsorptions give rise to similar electronic structures at low coverages, indicating a free-electron-like character of the adsorption surfaces.
Comparison of GARCH, Neural Network and Support Vector Machine in Financial Time Series Prediction

This article applied GARCH model instead AR or ARMA model to compare with the standard BP and SVM in forecasting of the four international including two Asian stock markets indices.These models were evaluated on five performance metrics or criteria. Our experimental results showed the superiority of SVM and GARCH models, compared to the standard BP in forecasting of the four international stock markets indices.
A Phase II study of the safety and efficacy of teriflunomide in multiple sclerosis with relapses.

BACKGROUND
Teriflunomide, a dihydro-orotate dehydrogenase inhibitor, has immunomodulatory effects, including the ability to suppress experimental allergic encephalomyelitis. In this randomized, double-blind, placebo-controlled Phase II study, the authors examined the safety and efficacy of oral teriflunomide in multiple sclerosis (MS) with relapses.


METHODS
Patients (n = 179) with relapsing-remitting MS (n = 157) or secondary progressive MS with relapses (n = 22) were randomized to receive placebo, teriflunomide 7 mg/day, or teriflunomide 14 mg/day for 36 weeks. MRI brain scans were performed every 6 weeks. The primary endpoint was the number of combined unique active lesions per MRI scan. Secondary endpoints included MRI-defined disease burden, relapse frequency, and disability increase.


RESULTS
The median number of combined unique active lesions per scan was 0.5, 0.2, and 0.3 in the placebo, teriflunomide 7 mg/day (p < 0.03 vs placebo), and teriflunomide 14 mg/day (p < 0.01 vs placebo) groups during the 36-week double-blind treatment phase. Teriflunomide-treated patients also had significantly fewer T1 enhancing lesions per scan, new or enlarging T2 lesions per scan, and new T2 lesions. Patients receiving teriflunomide 14 mg/day had significantly reduced T2 disease burden. Teriflunomide treatment resulted in trends toward a lower annualized relapse rate and fewer relapsing patients (14 mg/day only) vs placebo. Significantly fewer patients receiving teriflunomide 14 mg/day vs placebo demonstrated disability increase. Treatment was well tolerated; numbers of adverse events and serious adverse events were similar in all treatment groups.


CONCLUSION
Oral teriflunomide was effective in reducing MRI lesions and was well tolerated in patients with relapsing multiple sclerosis.
Trends in acute myocardial infarction in young patients and differences by sex and race, 2001 to 2010.

BACKGROUND
Various national campaigns launched in recent years have focused on young women with acute myocardial infarctions (AMIs). Contemporary longitudinal data about sex differences in clinical characteristics, hospitalization rates, length of stay (LOS), and mortality have not been examined.


OBJECTIVES
This study sought to determine sex differences in clinical characteristics, hospitalization rates, LOS, and in-hospital mortality by age group and race among young patients with AMIs using a large national dataset of U.S. hospital discharges.


METHODS
Using the National Inpatient Sample, clinical characteristics, AMI hospitalization rates, LOS, and in-hospital mortality were compared for patients with AMI across ages 30 to 54 years, dividing them into 5-year subgroups from 2001 to 2010, using survey data analysis techniques.


RESULTS
A total of 230,684 hospitalizations were identified with principal discharge diagnoses of AMI in 30- to 54-year-old patients from Nationwide Inpatient Sample data, representing an estimated 1,129,949 hospitalizations in the United States from 2001 to 2010. No statistically significant declines in AMI hospitalization rates were observed in the age groups <55 years or stratified by sex. Prevalence of comorbidities was higher in women and increased among both sexes through the study period. Women had longer LOS and higher in-hospital mortality than men across all age groups. However, observed in-hospital mortality declined significantly for women from 2001 to 2010 (from 3.3% to 2.3%, relative change 30.5%; p for trend < 0.0001) but not for men (from 2% to 1.8%, relative change 8.6%; p for trend = 0.60).


CONCLUSIONS
AMI hospitalization rates for young people have not declined over the past decade. Young women with AMIs have more comorbidity, longer LOS, and higher in-hospital mortality than young men, although their mortality rates are decreasing.
Iodine-131-anti-B1 radioimmunotherapy for B-cell lymphoma.

PURPOSE
The CD20 B-lymphocyte surface antigen expressed by B-cell lymphomas is an attractive target for radioimmunotherapy, treatment using radiolabeled antibodies. We conducted a phase I dose-escalation trial to assess the toxicity, tumor targeting, and efficacy of nonmyeloablative doses of an anti-CD20 monoclonal antibody (anti-B1) labeled with iodine-131 (131I) in 34 patients with B-cell lymphoma who had failed chemotherapy.


PATIENTS AND METHODS
Patients were first given tracelabeled doses of 131I-labeled anti-B1 (15 to 20 mg, 5 mCi) to assess radiolabeled antibody biodistribution, and then a radioimmunotherapeutic dose (15 to 20 mg) labeled with a quantity of 131I that would deliver a specified centigray dose of whole-body radiation predicted by the tracer dose. Whole-body radiation doses were escalated from 25 to 85 cGy in sequential groups of patients in 10-cGy increments. To evaluate if radiolabeled antibody biodistribution could be optimized, initial patients were given one or two additional tracer doses on successive weeks, each dose preceded by an infusion of 135 mg of unlabeled anti-B1 one week and 685 mg the next. The unlabeled antibody dose resulting in the most optimal tracer biodistribution was also given before the radioimmunotherapeutic dose. Later patients were given a single tracer dose and radioimmunotherapeutic dose preceded by infusion of 685 mg of unlabeled anti-B1.


RESULTS
Treatment was well tolerated. Hematologic toxicity was dose-limiting, and 75 cGy was established as the maximally tolerated whole-body radiation dose. Twenty-eight patients received radioimmunotherapeutic doses of 34 to 161 mCi, resulting in complete remission in 14 patients and a partial response in eight. All 13 patients with low-grade lymphoma responded, and 10 achieved a complete remission. Six of eight patients with transformed lymphoma responded. Thirteen of 19 patients whose disease was resistant to their last course of chemotherapy and all patients with chemotherapy-sensitive disease responded. The median duration of complete remission exceeds 16.5 months. Six patients remain in complete remission 16 to 31 months after treatment.


CONCLUSION
Nonmyeloablative radioimmunotherapy with 131I-anti-B1 is associated with a high rate of durable remissions in patients with B-cell lymphoma refractory to chemotherapy.
Parental feeding practices predict authoritative, authoritarian, and permissive parenting styles.

BACKGROUND
Our goal was to identify how parental feeding practices from the nutrition literature link to general parenting styles from the child development literature to understand how to target parenting practices to increase effectiveness of interventions. Stand-alone parental feeding practices could be targeted independently. However, parental feeding practices linked to parenting styles require interventions treating underlying family dynamics as a whole.


OBJECTIVE
To predict parenting styles from feeding practices and to test three hypotheses: restriction and pressure to eat are positively related whereas responsibility, monitoring, modeling, and encouraging are negatively related to an authoritarian parenting style; responsibility, monitoring, modeling, and encouraging are positively related whereas restriction and pressure to eat are negatively related to an authoritative parenting style; a permissive parenting style is negatively linked with all six feeding practices.


DESIGN
Baseline data of a randomized-controlled intervention study.


SUBJECTS/SETTING
Two hundred thirty-nine parents (93.5% mothers) of first-grade children (134 boys, 105 girls) enrolled in rural public schools.


MEASURES
Parental responses to encouraging and modeling questionnaires and the Child Feeding Questionnaire, as well as parenting styles measured by the Parenting Styles and Dimensions Questionnaire.


STATISTICAL ANALYSES
Correlation and regression analyses.


RESULTS
Feeding practices explained 21%, 15%, and 8% of the variance in authoritative, authoritarian, and permissive parenting, respectively. Restriction, pressure to eat, and monitoring (negative) significantly predicted an authoritarian style (Hypothesis 1); responsibility, restriction (negative), monitoring, and modeling predicted an authoritative style (Hypothesis 2); and modeling (negative) and restriction significantly predicted a permissive style (Hypothesis 3).


CONCLUSIONS
Parental feeding practices with young children predict general parenting styles. Interventions that fail to address underlying parenting styles are not likely to be successful.
Chapter 11 Transfer Learning

Human learners appear to have inherent ways to transfer knowledge between tasks. That is, we recognize and apply relevant knowledge from previous learning experiences when we encounter new tasks. The more related a new task is to our previous experience, the more easily we can master it. Common machine learning algorithms, in contrast, traditionally address isolated tasks. Transfer learning attempts to improve on traditional machine learning by transferring knowledge learned in one or more source tasks and using it to improve learning in a related target task (see Figure 1). Techniques that enable knowledge transfer represent progress towards making machine learning as efficient as human learning. This chapter provides an introduction to the goals, settings, and challenges of transfer learning. It surveys current research in this area, giving an overview of the state of the art and outlining the open problems. ABStrAct