LLukas22/scidocs huggingface dataset:
New Angles for Global Software Engineering Research? - Keynote Summary

Talk Summary In the late 1990s the Software Engineering community recognized that there was a problem with delivering global software projects to a high quality in an efficient manner. As a consequence, researchers, in the now ‘Global Software Engineering Research community’, carried out significant studies into GSE problems. But, did we really find what we expected? Did we expect that project delays were due solely to technical software engineering problems? Did we really think that software engineering techniques could resolve all GSE problems? Maybe that is what we expected – but that is not what we found. Of course Software Engineering techniques can solve some of the problems! However, the reality is that many of the issues we now discuss within the GSE community are social and socio-technical. We talk about culture and communication. We consider gender issues. Project management is high on our agenda. And what this portrays is the interdisciplinary nature of GSE research.
Structural and electrochemical characterization of Zr–C–N–Ag coatings deposited by DC dual magnetron sputtering

Abstract ZrCN coatings with incorporated silver were deposited on 316L stainless steel by dual reactive magnetron sputtering to evaluate the silver influence on the structural properties and corrosion resistance of the films. Samples composition was assessed by electron probe microanalysis. Glow discharge optical emission spectroscopy was used to determine the distribution of silver in the films. Structural characterization was performed by X-ray diffraction and Raman spectroscopy. Corrosion resistance was evaluated by potentiodynamic test and electrochemical impedance spectroscopy. Results revealed enhanced corrosion resistance properties of the coated steel and higher coatings reactivity when incorporated with silver, showing a plausible silver release increment.
Bridging therapy with low molecular weight heparin in patients with atrial fibrillation undergoing percutaneous coronary intervention with stent implantation: the AFCAS study.

BACKGROUND
Recent reports have provided evidence that bridging therapy with low-molecular-weight heparin (LMWH) may increase bleeding complications in patients with atrial fibrillation (AF) on oral anticoagulation undergoing percutaneous coronary intervention (PCI). We sought to assess mid-term bleeding and thromboembolic events in patients from the AFCAS registry discharged on triple therapy (TT).


METHODS
AFCAS is a multicenter, prospective registry enrolling patients with AF undergoing PCI. The primary endpoints were: 1) bleeding complications as defined by the bleeding academic research criteria (BARC); 2) a composite of cardiac and cerebrovascular events (MACCE) at 3 and 12 month follow-ups.


RESULTS
Altogether 663 out of 929 consecutive patients were discharged on TT, either on oral vitamin K antagonist (VKA-TT) (n=498) or bridging LMWH-TT (n=165). Patients on LMWH-TT had more often diabetes, heart failure, and hypertension compared to those on VKA-TT. The rates of major bleeding events (BARC≥3) (11.5% vs. 6.0%, p=0.03) as well as MACCE (11.5% vs. 5.0%, p=0.006) were higher in the LMWH-TT group compared to VKA-TT group at 3 months follow-up. In a Cox multivariate regression model and propensity-score matched analysis LMWH-TT increased the risk for major BARC bleeding events at 3 and 12 month follow-ups.


CONCLUSIONS
In this large, prospective, real-world population of patients with AF undergoing PCI patients discharged on LMWH-TT had a significantly higher risk for major bleeds in comparison to patients discharged on VKA-TT. LMWH-bridging therapy appeared harmful in this subset of patient on oral anticoagulation.
A phase I trial of ANG1/2-Tie2 inhibitor trebaninib (AMG386) and temsirolimus in advanced solid tumors (PJC008/NCI♯9041)

Background There is crosstalk between the ANG-Tie2 and the PI3K/Akt/mTOR pathways. Combined ANG1/2 and mTOR blockade may have additive anti-cancer activity. The combination of trebananib, an inhibitor of ANG1/2-Tie2 interaction, with temsirolimus was evaluated in patients with advanced solid tumors to determine tolerability, maximum tolerated dose (MTD), and preliminary antitumor activity. Methods Patients were enrolled using 3 + 3 design, and were given intravenous trebananib and temsirolimus on Day 1, 8, 15 and 22 of a 28-day cycle. Dose limiting toxicities (DLTs) were evaluated during cycle 1. Peripheral blood was collected for evaluation of Tie2-expressing monocytes (TEMs) and thymidine phosphorylase (TP). Sparse pharmacokinetic (PK) sampling for trebananib drug levels was performed on Day 1 and 8 of cycle 2. Results Twenty-one patients were enrolled, 6 at dose level (DL) 1, 7 at DL −1, and 8 at DL −2. No effect of temsirolimus on trebananib PK was observed. The most common treatment-related adverse events (AEs) were: fatigue (81 %), edema (62 %), anorexia (57 %), nausea (52 %), rash (43 %) and mucositis (43 %). The most common grade ≥ 3 AEs included lymphopenia (28 %) and fatigue (28 %). The MTD was exceeded at DL-2. Of 18 response evaluable patients, 1 partial response was observed (ER+/HER2−/PIK3CA mutant breast cancer) and 4 patients had prolonged SD ≥ 24 weeks. No correlation with clinical benefit was observed with change in number TEMs or TP expression in TEMs with treatment. Conclusions The MTD was exceeded at trebananib 10 mg/kg weekly and temsirolimus 20 mg weekly, with frequent overlapping toxicities including fatigue, edema, and anorexia.
U-Pb LA-SF-ICP-MS zircon geochronology of the Serbo-Macedonian Massif, Greece: palaeotectonic constraints for Gondwana-derived terranes in the Eastern Mediterranean

The Pirgadikia Terrane in northern Greece forms tectonic inliers within the Vardar suture zone bordering the Serbo-Macedonian Massif to the southwest. It comprises Cadomian basement rocks of volcanic-arc origin and very mature quartz-rich metasedimentary rocks. U–Pb laser ablation sector-field inductively-coupled plasma mass spectrometry analyses of detrital zircons from the latter reveal a marked input from a Cadomian–Pan-African source with minor contribution from Mesoproterozoic, Palaeoproterozoic and Archaean sources. The metasedimentary rocks are correlated with Ordovician overlap sequences at the northern margin of Gondwana on the basis of their maturity and zircon age spectra. The Pirgadikia Terrane can be best interpreted as a peri-Gondwana terrane of Avalonian origin, which was situated close to the Cadomian terranes in the Late Neoproterozoic–Early Palaeozoic, very much like the Istanbul Terrane. The second unit investigated is the Vertiskos Terrane, which constitutes the major part of the Serbo-Macedonian Massif in Greece. It comprises predominantly igneous rocks of Silurian age and minor metasedimentary rocks of unknown age and provenance. U–Pb analyses of detrital zircons from a garnetiferous mica schist of the Vertiskos Terrane indicate derivation from 550 to 1,150 Ma-old source rocks with a major Cadomian peak. This, combined with minor input of [1,950 Ma-old zircons and the absence of ages between ca. 1.2 and 1.7 Ga suggests a NW Africa source. The protolith age of the garnetiferous mica schist is presumably Early Ordovician. One sample of garnet-bearing biotite gneiss, interpreted as meta-igneous rock, comprises predominantly subhedral zircons of igneous origin with late Middle Ordovician to Silurian ages. We suggest that the rock association of the Vertiskos Terrane is part of an ancient active-margin succession of the Hun superterrane, comparable to successions of the Austroand Intra-Alpine Terranes. The new data of this study provide evidence of occurrences of Avaloniaand Armorica-derived terranes in the Eastern Mediterranean and moreover help to clarify palaeogeographic reconstructions for the peri-Gondwana realm in the Early Palaeozoic.
Failure diagnosis and nonlinear observer. Application to a hydraulic process

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. Failure diagnosis and nonlinear observer. Application to a hydraulic process Hassan Hammouri, Pousga Kabore, Sami Othman, Jean Biston
Toward excellence in testosterone testing: a consensus statement.

BACKGROUND
Testosterone assays are widely used. However, deficiencies in these assays limit their broad and effective implementation and threaten the health of those patients whose medical care relies upon its accurate measurement. Furthermore, the translation of research findings into information useful for patient care, such as new evidence-based clinical guidelines, is not possible unless both research and clinical assays are held to higher standards than are currently required. A group of concerned stakeholders was convened to address this problem.


METHODS
Representatives of multiple professional societies, government, and industry, having a stake in ensuring that testosterone levels are measured accurately and reliably, met to identify goals, objectives, and actions necessary to bring about the standardization of assays for testosterone.


RESULTS
To ensure highly accurate testosterone testing that will result in improved diagnosis, treatment, and prevention of disease through the use of standardized assays, a series of recommendations were agreed upon. The recommendations included the following: technical improvements for assay standardization; education of health care providers, patients, and all others concerned with testosterone testing; plans to encourage all concerned journals, government agencies, and health insurance companies to support this effort; and encouragement to manufacturers to develop better and more cost effective assays.


CONCLUSION
A preliminary timeline was set out to implement the recommendations of the Group.
Resource utilization in patients with schizophrenia who initiated risperidone long-acting therapy: results from the Schizophrenia Outcomes Utilization Relapse and Clinical Evaluation (SOURCE)

BACKGROUND
Schizophrenia is a chronic mental health disorder associated with increased hospital admissions and excessive utilization of outpatient services and long-term care. This analysis examined health care resource utilization from a 24-month observational study of patients with schizophrenia initiated on risperidone long-acting therapy (RLAT).


METHODS
Schizophrenia Outcomes Utilization Relapse and Clinical Evaluation (SOURCE) was a 24-month observational study designed to examine real-world treatment outcomes by prospectively following patients with schizophrenia initiated on RLAT. At baseline visit, prior hospitalization and ER visit dates were obtained for the previous 12 months and subsequent hospitalization visit dates were obtained at 3-month visits, if available. The health care resource utilization outcomes measures observed in this analysis were hospitalizations for any reason, psychiatric-related hospitalizations, and emergency room (ER) visits. Incidence density analysis was used to assess pre-event and postevent rates per person-year (PY).


RESULTS
The primary medical resource utilization analysis included 435 patients who had a baseline visit, ≥1 postbaseline visits after RLAT initiation, and valid hospitalization dates. The number of hospitalizations and ER visits per PY declined significantly (p < .0001) after initiation with RLAT. A 41% decrease (difference of -0.29 hospitalizations per PY [95% CI: -0.39 to -0.18] from baseline) in hospitalizations for any reason, a 56% decrease (a difference of -0.35 hospitalizations per PY [95% CI: -0.44 to -0.26] from baseline) in psychiatric-related hospitalizations, and a 40% decrease (-0.26 hospitalizations per PY [95% CI: -0.44 to -0.10] from baseline) in ER visits were observed after the baseline period. The percentage of psychiatric-related hospitalizations decreased significantly after RLAT initiation, and patients had fewer inpatient hospitalizations and ER visits (all p < .0001).


CONCLUSION
The results suggest that treatment with RLAT may result in decreased hospitalizations for patients with schizophrenia.


TRIAL REGISTRATION
ClinicalTrials.gov: NCT00246194.
Impact of microstructure on local carrier lifetime in perovskite solar cells

The remarkable performance of hybrid perovskite photovoltaics is attributed to their long carrier lifetimes and high photoluminescence (PL) efficiencies. High-quality films are associated with slower PL decays, and it has been claimed that grain boundaries have a negligible impact on performance. We used confocal fluorescence microscopy correlated with scanning electron microscopy to spatially resolve the PL decay dynamics from films of nonstoichiometric organic-inorganic perovskites, CH3NH3PbI3(Cl). The PL intensities and lifetimes varied between different grains in the same film, even for films that exhibited long bulk lifetimes. The grain boundaries were dimmer and exhibited faster nonradiative decay. Energy-dispersive x-ray spectroscopy showed a positive correlation between chlorine concentration and regions of brighter PL, whereas PL imaging revealed that chemical treatment with pyridine could activate previously dark grains.
Impact of Age at Conization on Obstetrical Outcome: A Case-Control Study

OBJECTIVE
The aim of the study was to assess whether an age younger than 25 years at conization affected future pregnancy outcome as an independent factor.


MATERIALS AND METHODS
A retrospective study of 115 women who underwent both loop electrosurgical excision procedure (LEEP) and subsequent pregnancy follow-up in a referral center was conducted. Two groups were considered: patients younger than 25 years at the time of LEEP (n = 42) and 25 years or older (n = 73). Analyzed data were occurrence of preterm adverse obstetrical event and, specifically, preterm labor (PL) and preterm rupture of membranes; stratification based on term of occurrence was performed: less than 37 weeks of amenorrhea (WA), less than 34 WA, and less than 26 WA.


RESULTS
Patients characteristics were comparable in terms of excised specimen thickness and pathological analysis, as well as for tobacco intoxication during pregnancy. Although there was no difference of term at delivery or total number of preterm adverse obstetrical events, we found a significant increase of events (19% vs 4.1%) and PL (19% vs 0%) before 26 WA in the group of patients younger than 25 years. After adjusting for excised specimen thickness, the same results were found for thickness of 15 mm or less (respectively, 16.7% vs 3.3% and 16.7% vs 0%). For thickness of greater than 15 mm, only ratio of PL before 26 WA was higher in the group of patients younger than 25 years (33.3% vs 0%).


CONCLUSIONS
Age younger than 25 years at the time of LEEP seems to be is associated with a more frequent occurrence of extremely early preterm adverse obstetrical events, particularly PL.
Assessment of liver oxygenation with BOLD MRI at 3 T . Feasibility study

Introduction Liver biopsy is the gold standard for the liver fibrosis evaluation in patients affected by chronic liver disease. In healthy livers the vascular input is provided by the portal vein and hepatic artery, with the portal vein representing the main source of blood supply and normally the oxygenation of the liver is carefully auto-regulated. As hepatic fibrosis progresses it is thought the liver parenchyma become hypoxic which drives an increase in the relative arterial supply which has been observed with many different techniques.
Integral Resonant Control for Vibration Damping and Precise Tip-Positioning of a Single-Link Flexible Manipulator

In this paper, we propose a control design method for single-link flexible manipulators. The proposed technique is based on the integral resonant control (IRC) scheme. The controller consists of two nested feedback loops. The inner loop controls the joint angle and makes the system robust to joint friction. The outer loop, which is based on the IRC technique, damps the vibration and makes the system robust to the unmodeled dynamics (spill-over) and resonance frequency variations due to changes in the payload. The objectives of this work are: 1) to demonstrate the advantages of IRC, which is a high-performance controller design methodology for flexible structures with collocated actuator-sensor pairs and 2) to illustrate its capability of achieving precise end-point (tip) positioning with effective vibration suppression when applied to a typical flexible manipulator. The theoretical formulation of the proposed control scheme, a detailed stability analysis and experimental results obtained on a flexible manipulator are presented.
Performance studies of Hamamatsu R9800 photomultiplier tube with a new active base designed for use in the Hall D Broadband tagger Hodoscope

This paper presents the results of a study of a high rate photomultiplier and active base assembly designed for use in scintillator counters of the Hall D Jefferson Lab Broadband fixed-array Tagging Hodoscope. In its standard configuration the fixed-array hodoscope consists of 218 plastic scintillator counters made with Hamamatsu R9800 one inch in diameter photomultiplier tube. All tubes are equipped with designed at JLab new active base. The base comprised of a high voltage divider integrated with amplifiers powered by current flowing through the divider (U.S. Patent No. 6,791,269). This original design allows limiting the PMT anode current to 15-20 μA at a 4 MHz count rate, and allows tube operation at lower high voltage bias voltage while retaining a desired overall gain and dynamic range of output signals. The performance of the PMT assemblies were studied at Jeffeson Lab using a picosecond laser (PLP-10). Subsequently, two hundred fifty PMT and base assemblies were manufactured and tested. The results of testing the R9800 photomultiplier in a new active base are presented and discussed.
Realization with CCG

Here I give an overview of recent work on natural language realization with Combinatory Categorial Grammar, done by Michael White and his colleagues, with some more specific descriptions of the algorithms used, where they were unclear to me. In particular, I focus on the work presented in his 2007 paper [5], in which White et al describe a process for extracting a grammar from the CCGBank and using it to generate text based on semantic descriptions given in HLDS, the Hybrid Logic Dependency Semantics. I also give some background from his earlier work, a description of some background ideas.
Comparative Evaluation of Big-Data Systems on Scientific Image Analytics Workloads

Education University of Washington, School of Computer Science & Engineering Seattle, WA 2017, Postdoc, mentor: Magdalena Balazinska Illinois Institute of Technology, Department of Computer Science Chicago, IL 2015, PhD, committee: Ioan Raicu, Zhiling Lan, Xian-He Sun Emory University, Department of Mathematics & Computer Science Atlanta, GA 2008, MS, advisor: James J. Lu Katholieke Universiteit Leuven, Faculty of Engineering Science Belgium 2005, Diploma cum laude, advisor: Irène Gijbels
Non-ionic adsorption chromatography of proteins.

Abstract Evidence is presented indicating that protein separation by adsorption chromatography, based on differential non-ionic interaction with immobilized hydrophobic ligands, potentially is as generally applicable as ion-exchange chromatography. A procedure for the normalization of binding capacities of amine-substituted agaroses has been presented. Attempts have been made at the separation of proteins in normal human blood serum by means of hydrophobicity gradients consisting of series of interconnected columns of n -alkylamino-agaroses of increasing hydrophobicities and equilibrated with 3 M NaCl. The γ-globulin fraction, or components thereof, can be bound hydrophobically as well as through another type of salt(NaCl)-stable but non-hydrophobic binding.
Beyond traditional DTN routing: social networks for opportunistic communication

This article examines the evolution of routing protocols for intermittently connected ad hoc networks and discusses the trend toward socialbased routing protocols. A survey of current routing solutions is presented, where routing protocols for opportunistic networks are classified based on the network graph employed. The need to capture performance trade-offs from a multi-objective perspective is highlighted.
Novel soy protein wound dressings with controlled antibiotic release: mechanical and physical properties.

Naturally derived materials are becoming widely used in the biomedical field. Soy protein has advantages over various types of natural proteins employed for biomedical applications due to its low price, non-animal origin and relatively long storage time and stability. In the current study soy protein isolate (SPI) was investigated as a matrix for wound dressing applications. The antibiotic drug gentamicin was incorporated into the matrix for local controlled release and, thus, protection against bacterial infection. Homogeneous yellowish films were cast from aqueous solutions. After cross-linking they combined high tensile strength and Young's modulus with the desired ductility. The plasticizer type, cross-linking agent and method of cross-linking were found to strongly affect the tensile properties of the SPI films. Selected SPI films were tested for relevant physical properties and the gentamicin release profile. The cross-linking method affected the degree of water uptake and the weight loss profile. The water vapor transmission rate of the films was in the desired range for wound dressings (∼2300 g m(-2) day(-1)) and was not affected by the cross-linking method. The gentamicin release profile exhibited a moderate burst effect followed by a decreasing release rate which was maintained for at least 4 weeks. Diffusion was the dominant release mechanism of gentamicin from cross-linked SPI films. Appropriate selection of the process parameters yielded SPI wound dressings with the desired mechanical and physical properties and drug release behavior to protect against bacterial infection. These unique structures are thus potentially useful as burn and ulcer dressings.