LLukas22/scidocs huggingface dataset:
Development and standardization of a "do-eat" activity of daily living performance test for children.

BACKGROUND
The Do-Eat was developed to evaluate daily task performance abilities among children with developmental coordination disorder (DCD). This study investigated the tool's reliability and validity.


METHOD
Participants were 59 children ages 5 to 6.5 years; 30 children diagnosed with DCD according to the DSM-IV-TR; and a control group of 29 children, who were matched for age, gender, and sociodemographic background.


RESULTS
Both the Do-Eat and the accompanying Parent Questionnaire yielded high internal consistency (alpha s = .89-.93). Construct validity was demonstrated by significant between-group differences on the Do-Eat (t[57] = 14.09, p<.001) and the Parent Questionnaire (t[57] = 3.64, p<.001). Significant correlations between children's scores on the sensory-motor component of the Do-Eat and the Movement Assessment Battery for Children final score confirmed concurrent validity (r = -.86, p<.001).


CONCLUSIONS
Results suggest that the Do-Eat is a reliable, valid tool for identifying children at risk for DCD.
PROJECT MANAGEMENT MATURITY MODEL : THE CASE IN AN AUTOMOTIVE INDUSTRY IN BRAZIL

This study discusses the theoretical concepts related to project management, specifically on the measurement of its implementation, through the concepts of maturity models. Moreover, in order to confirm the theoretical concepts related, it will be presented the results of a survey data conducted in an automotive industry in Brazil (Rio de Janeiro state), through the research of maturity proposed by Darci Prado. This survey will demonstrate the perception of employees at the different areas on the project maturity in this organization. In addition, the result found revealed that the organization analyzed is at the levels observed and calculated, considering the average level of maturity of the region and country. It is concluded that the Brazilian methodology adopted was effective in terms of measuring the level of maturity in a Brazilian organization. It is estimated that this work can contribute to those organizations concerned in the application of project management and that these practices become entrenched and fully disseminated and becoming part of their culture.
Towards a Global Barcode Library for Lymantria (Lepidoptera: Lymantriinae) Tussock Moths of Biosecurity Concern

BACKGROUND
Detecting and controlling the movements of invasive species, such as insect pests, relies upon rapid and accurate species identification in order to initiate containment procedures by the appropriate authorities. Many species in the tussock moth genus Lymantria are significant forestry pests, including the gypsy moth Lymantria dispar L., and consequently have been a focus for the development of molecular diagnostic tools to assist in identifying species and source populations. In this study we expand the taxonomic and geographic coverage of the DNA barcode reference library, and further test the utility of this diagnostic method, both for species/subspecies assignment and for determination of geographic provenance of populations.


METHODOLOGY/PRINCIPAL FINDINGS
Cytochrome oxidase I (COI) barcodes were obtained from 518 individuals and 36 species of Lymantria, including sequences assembled and generated from previous studies, vouchered material in public collections, and intercepted specimens obtained from surveillance programs in Canada. A maximum likelihood tree was constructed, revealing high bootstrap support for 90% of species clusters. Bayesian species assignment was also tested, and resulted in correct assignment to species and subspecies in all instances. The performance of barcoding was also compared against the commonly employed NB restriction digest system (also based on COI); while the latter is informative for discriminating gypsy moth subspecies, COI barcode sequences provide greater resolution and generality by encompassing a greater number of haplotypes across all Lymantria species, none shared between species.


CONCLUSIONS/SIGNIFICANCE
This study demonstrates the efficacy of DNA barcodes for diagnosing species of Lymantria and reinforces the view that the approach is an under-utilized resource with substantial potential for biosecurity and surveillance. Biomonitoring agencies currently employing the NB restriction digest system would gather more information by transitioning to the use of DNA barcoding, a change which could be made relatively seamlessly as the same gene region underlies both protocols.
Effectiveness of peer assessment for implementing a Dutch physical therapy low back pain guideline: cluster randomized controlled trial.

BACKGROUND
Clinical practice guidelines are considered important instruments to improve quality of care. However, success is dependent on adherence, which may be improved using peer assessment, a strategy in which professionals assess performance of their peers in a simulated setting.


OBJECTIVE
The aim of this study was to determine whether peer assessment is more effective than case-based discussions to improve knowledge and guideline-consistent clinical reasoning in the Dutch physical therapy guideline for low back pain (LBP).


DESIGN
A cluster randomized controlled trial was conducted.


SETTING AND PARTICIPANTS
Ten communities of practice (CoPs) of physical therapists were cluster randomized (N=90): 6 CoPs in the peer-assessment group (n=49) and 4 CoPs in the case-based discussion group (control group) (n=41).


INTERVENTION
Both groups participated in 4 educational sessions and used clinical patient cases. The peer-assessment group reflected on performed LBP management in different roles. The control group used structured discussions.


MEASUREMENTS
Outcomes were assessed at baseline and at 6 months. The primary outcome measure was knowledge and guideline-consistent reasoning, measured with 12 performance indicators using 4 vignettes with specific guideline-related patient profiles. For each participant, the total score was calculated by adding up the percentage scores (0-100) per vignette, divided by 4. The secondary outcome measure was reflective practice, as measured by the Self-Reflection and Insight Scale (20-100).


RESULTS
Vignettes were completed by 78 participants (87%). Multilevel analysis showed an increase in guideline-consistent clinical reasoning of 8.4% in the peer-assessment group, whereas the control group showed a decline of 0.1% (estimated group difference=8.7%, 95% confidence interval=3.9 to 13.4). No group differences were found on self-reflection.


LIMITATIONS
The small sample size, a short-term follow-up, and the use of vignettes as a proxy for behavior were limitations of the study.


CONCLUSIONS
Peer assessment leads to an increase in knowledge and guideline-consistent clinical reasoning.
The effects of Zintona EC (a ginger extract) on symptomatic gonarthritis.

OBJECTIVE
Evaluation of the effect of a ginger extract (Zintona EC) on patients suffering from gonarthritis.


MATERIAL AND METHODS
Twenty-nine patients (6 men and 23 women) with symptomatic gonarthritis (ACR criteria), in the age range 42-85 years, were included after randomization in a double blind, placebo controlled, crossover study of 6 months' duration. The treatment group was given a ginger extract (250 mg of Zingiberis Rhizoma per capsule, qid), while the placebo group received the same number of identical looking capsules per day. The crossover occurred after 3 months of therapy. Results were evaluated by a 100mm visual analog scale (VAS) of pain on movement and of handicap.


RESULTS
Eight patients dropped out because of inefficacy, three from group 1 (ginger extract first) and five from group 2 (placebo first). One patient from group 1 and one from group 2 dropped out because of heartburn (while they were on ginger extract). Twenty patients completed the study period of 24 weeks and 19 that of 48 weeks follow-up. By the end of 24 weeks there was a highly statistically significant difference between the VAS of pain and handicap of the two groups (P<0.001). However, at crossover both groups showed a statistically significant decrease in VAS of pain on movement and of handicap, but the differences between the groups did not reach statistical significance.


CONCLUSIONS
Zintona EC was as effective as placebo during the first 3 months of the study, but at the end of 6 months, 3 months after crossover, the ginger extract group showed a significant superiority over the placebo group.
The role of bideterminants in the representation theory

This paper provides a brief survey discussing the role of bideterminants in the representation theory.
Lifestyle change recommendations in major depression: Do they work?

BACKGROUND
Modifying some lifestyle factors can be useful in depression, at least as an adjuvant treatment. Combining different lifestyle interventions seems to be an adequate strategy to increase their antidepressant efficacy according with preliminary studies, but this issue has not been enough investigated.


METHODS
The present study is a randomized, double-blinded, multicentre, two arm-parallel clinical trials, with a 12 month follow-up. The sample consisted of 273 Primary Care patients. Four combined hygienic-dietary written recommendations were given to the patients about diet, exercise, light exposure and sleep hygiene.


RESULTS
Both active and control interventions were associated with improvement on BDI (Beck Depression Inventory) scores. However, there were not statistically significant differences (7.0 vs. 7.6; p=0.594).


LIMITATIONS
We were unable to monitor whether patients carry out recommendations. Intervention could be too difficult to accomplish for depressed patients without enough support and supervision.


CONCLUSIONS
Just giving written lifestyle recommendations are not enough for depressive patients to benefit from them, so perhaps lifestyle change recommendations work or do not work on Depression depending on how they are presented to patients and on monitoring systems of their implementation.
Emotional and Cognitive Predictors of the Enjoyment of Reality-Based and Fictional Television Programming : An Elaboration of the Uses and Gratifications Perspective

This article reports the results of two studies designed to compare predictors of enjoyment of reality-based and fictional television programming. In Study 1, 260 adults completed a survey of their cognitive and emotional reactions to either the fictional or reality-based programming that they generally watch. In Study 2, 502 adults completed a similar survey but with a particular reality-based or fictional program in mind. Results suggest first that though voyeurism (i.e., curiosity about others) appears to be a key distinguishing gratification between reality and fictional programming, it is not always a predictor of reality television enjoyment. Indeed, many predictors of enjoyment, like happiness, parasocial relationships, social comparison, self-awareness, negative outcome, and dramatic challenge, varied as much among types of reality programs as between reality and fiction. Of particular interest, three variables—learning, suspense, and transportation—had opposite effects on enjoyment, depending on their programming context. The implications of these findings, as well as the role of perceived realism and our ability to explain more variance in enjoyment of reality versus fictional programming, are addressed. Apart from its insight into the reality television phenomenon, this research helps to more clearly articulate the cognitive and emotional underpinnings of enjoyment and MEDIA PSYCHOLOGY, 8, 421–447 Copyright © 2006, Lawrence Erlbaum Associates, Inc.
Small Changes, Big Changes: An Updated View on the Android Permission System

Since the appearance of Android, its permission system was central to many studies of Android security. For a long time, the description of the architecture provided by Enck et al. in [31] was immutably used in various research papers. The introduction of highly anticipated runtime permissions in Android 6.0 forced us to reconsider this model. To our surprise, the permission system evolved with almost every release. After analysis of 16 Android versions, we can confirm that the modifications, especially introduced in Android 6.0, considerably impact the aptness of old conclusions and tools for newer releases. For instance, since Android 6.0 some signature permissions, previously granted only to apps signed with a platform certificate, can be granted to third-party apps even if they are signed with a non-platform certificate; many permissions considered before as threatening are now granted by default. In this paper, we review in detail the updated system, introduced changes, and their security implications. We highlight some bizarre behaviors, which may be of interest for developers and security researchers. We also found a number of bugs during our analysis, and provided patches to AOSP where possible.
Facilitated bone mineral density testing versus hospital-based case management to improve osteoporosis treatment for hip fracture patients: additional results from a randomized trial.

OBJECTIVE
We previously demonstrated that a case manager intervention improved osteoporosis (OP) treatment within 6 months of hip fracture compared with usual care. The second phase of the randomized trial compared a less intensive intervention, facilitated bone mineral density (BMD) testing, with usual care and the case manager intervention.


METHODS
We initially randomized 220 hip fracture patients to either an OP case manager intervention or usual care. After completing the original trial at 6 months postfracture, usual care patients were reallocated to facilitated BMD testing; BMD tests were arranged and results sent to primary care physicians. Main outcomes (bisphosphonate treatment, BMD tests, receipt of appropriate care) were reascertained 1 year following hip fracture and compared with outcomes achieved by the OP case manager intervention and usual care.


RESULTS
Compared with usual care, facilitated BMD testing increased testing from 29% to 68% (P < 0.001), bisphosphonate use from 22% to 38% (P < 0.001), and receipt of appropriate care from 26% to 45% (P < 0.001). The more intensive (70 versus 30 minutes) and expensive ($56 versus $24 Canadian per patient) OP case manager intervention led to significantly higher bisphosphonate use (54% versus 38%; P = 0.03), receipt of appropriate care (71% versus 45%; P < 0.001), and more BMD testing (80% versus 68%; P = 0.06) than usual care followed by facilitated BMD testing.


CONCLUSION
Compared with usual care, 2 different inexpensive interventions resulted in significant increases in appropriate management of OP after hip fracture. The magnitude of improvements achieved was directly related to the intensity of the interventions.
Canonical forms for linear differential-algebraic equations with variable coefficients

We give a new set of local characterizing quantities for the treatment of linear differential–algebraic equations with variable coefficients. This leads to new global invariances under which we can find a generalization of the global (or differentiation) index and get a new existence and uniqueness theorem.
The impact of second to sixth line therapy on survival of relapsed ovarian cancer after primary taxane/platinum-based therapy.

BACKGROUND
Despite recent progress in the treatment of ovarian cancer, the majority of patients eventually relapse. There is little information on the effectiveness of chemotherapy in higher treatment lines.


PATIENTS AND METHODS
Characterization of the second to sixth line therapy and its effects on survival was carried out, based on data of n = 1620 patients from three large randomized phase III trials investigating primary therapy.


RESULTS
Median progression-free survival (PFS) after the first, second, third, fourth and fifth relapse was 10.2 [95% confidence interval (CI) 9.6-10.7], 6.4 (5.9-7.0), 5.6 (4.8-6.2), 4.4 (3.7-4.9) and 4.1 (3.0-5.1) months, respectively. Median overall survival (OS) after the first, second, third, fourth and fifth relapse was 17.6 (95% CI 16.4-18.6), 11.3 (10.4-12.9), 8.9 (7.8-9.9), 6.2 (5.1-7.7) and 5.0 (3.8-10.4) months, respectively. The most frequent second and third line chemotherapy was platinum combination (n = 313, 24.5%) and topotecan (n = 118, 23.6%), respectively. Relapse treatment improved PFS and OS at the second to fourth recurrence, although frequently not performed according to the standard of care. In multivariate analysis, platinum sensitivity and optimal primary tumor debulking were revealed as independent prognostic factors for PFS up to third relapse.


CONCLUSION
A maximum of three lines of subsequent relapse treatment seems to be beneficial for patients with recurrent ovarian cancer. Optimal primary tumor debulking and platinum sensitivity remain independent prognostic factors even after more frequent relapses.
The development of postural adjustments during reaching in 6- to 18-month-old infants Evidence for two transitions

 The present study focused on the developmental changes of postural adjustments accompanying reaching movements in healthy infants. We made a longitudinal study of ten infants between 6 and 18 months of age. During each session multiple surface electromyograms of arm, neck, trunk and leg muscles at the right side of the body were recorded during right-handed reaching movements in two positions (”upright sitting” in an infant chair and ”long-leg” sitting without support). Simultaneously the whole session was recorded on video. Comparable data were present from the same infants at 3–5 months. Additionally, 18 infants (8–15 months) were assessed once during similar reaching tasks, but in these infants electromyographic activity of the trunk and neck muscles at both sides of the body were recorded. Our data revealed two transitions in the development of postural adjustments. The first transition was present around 6 months of age. At this age the postural muscles were infrequently activated during reaching movements. At 8 months ample postural activity reappeared and the infants developed the ability to adapt the postural adjustments to task-specific constraints such as arm movement velocity or the sitting position at the onset of the reaching movement. The second transition occurred between 12 and 15 months. Before 15 months the infants did not show consistent anticipatory postural activity, but from 15 months onwards they did, particularly in the neck muscles.
Preparation of PCL/silk fibroin/collagen electrospun fiber for urethral reconstruction

To prepare polycaprolactone (PCL)/silk fibroin/collagen electrospun nanofiber scaffold and test its effects on growth and proliferation of oral mucosal epithelial cells. Regenerated silk fibroin film, water-soluble collagen powder, and PCL, at mass ratios of 1:1:4, 1:1:8, and 1:1:10, were dissolved in hexafluoroisopropanol, and electrostatic spinning method was adopted to prepare PCL/silk fibroin/collagen electrospun nanofiber scaffold. In vitro cultured oral mucosal epithelial cells were inoculated on the material surface, MTT assay and scanning electron microscopy were adopted to study the growth and proliferation of oral mucosal epithelial cells on the material surface, and cell compatibility of PCL/silk fibroin/collagen electrospun nanofiber was evaluated. The result of MTT assay showed that oral mucosal epithelial cells were growing well on the PCL/silk fibroin/collagen electrospun nanofiber scaffold. Scanning electron microscopy showed that the prepared electrospun fiber was uniform in diameter and presented an interconnected porous net structure, and oral mucosal epithelial cells had a good growth form on the surface of the modified material. PCL/silk fibroin/collagen electrospun nanofiber scaffold has appropriate pore size and porosity, is suitable for the growth of oral mucosal epithelial cells, has good cell compatibility, and is a good scaffold for tissue engineering urethral reconstruction.
Granisetron, tropisetron, and ondansetron in the prevention of acute emesis induced by a combination of cisplatin–Adriamycin and by high-dose ifosfamide delivered in multiple-day continuous infusions

 The antiemetic efficacy of granisetron, ondansetron and tropisetron was evaluated in patients treated with cisplatin–Adriamycin (CDP/ADM) and ifosfamide (IFO) by continuous infusion (CI). In all, 90 patients with osteosarcoma were randomly assigned to receive granisetron (2 mg/m2), or ondansetron (5.3 mg/m2), or tropisetron (3.3 mg/m2) plus dexamethasone 8 mg/m2. Chemotherapy consisted of CDP (120 mg/m2, 48-h CI) followed by ADM (75 mg/m2, 24-h CI) and then, in the second cycle, delivered 3 weeks later, IFO 15 g/m2 (120-h CI). Complete protection (CP) from emesis was obtained on 59% of the 717 days of treatment, without significant differences among the three study drugs. A significantly higher rate of CP was obtained during chemotherapy with IFO than with CDP/ADM (69% vs 44%; P<0.0001). The rate of CP declined from the first to the last day of treatment for both CDP/ADM (61% to 27%, P<0.0001) and IFO (95% to 43%) cycles (P<0.0001). When CDP/ADM and IFO are delivered on multiple days by CI, granisetron, ondansetron and tropisetron have the same antiemetic efficacy, which declines from the first day onward through successive days.
Phase II study of single-agent gemcitabine in patients with advanced biliary tract cancer

Purpose: This phase II study was conducted to evaluate the efficacy and toxicity of single-agent gemcitabine in patients with advanced or metastatic biliary tract cancer. Patients and methods: Gemcitabine 1,000 mg/m2 was administered as an intravenous 30-min infusion on days 1, 8, and 15 for every 28 days. Results: Forty chemonaive patients with a median age of 61 (range 33–73) were enrolled, and all 40 patients were involved in efficacy and safety analyses. Seven (17.5%) achieved partial response; 15 (37.5%) had stable disease; 17 (42.5%) had progressive disease; and 1 (2.5%) was not evaluated. The median survival time was 7.6 months, and the 1-year survival rate was 25.0%. Grade 3/4 neutropenia occurred in 12 patients (30.0%), leukopenia in five patients (12.5%), and anemia in four patients (10.0%). The most common grade 3/4 nonhematologic toxicities were elevated ALT (15.0%) and elevated γ-GTP (12.5%). One patient had grade 4 hemolytic uremic syndrome and recovered after discontinuation of gemcitabine. Conclusions: In single-agent therapy, gemcitabine demonstrated moderate efficacy with manageable toxicity in patients with advanced or metastatic biliary tract cancer. Further evaluations are warranted, including the exact impact of gemcitabine on the management of advanced or metastatic biliary tract cancer.
Human-Centered Distributed Conversational Modeling: Efficient Modeling of Robust Virtual Human Conversations

Currently, applications that focus on providing conversations with virtual humans require extensive work to create robust conversational models. We present a new approach called Human-centered Distributed Conversational Modeling. Using this approach, users create conversational models in a distributed manner. To do this, end-users interact with virtual humans to provide new stimuli (questions and statements), and domain-specific experts (e.g. medical/psychology educators) provide new virtual human responses. Using this process, users become the primary developers of conversational models. We tested our approach by creating an example application, Virtual People Factory. Using Virtual People Factory, a pharmacy instructor and 186 pharmacy students were able to create a robust conversational model in 15 hours. This is approximately 10% of the time typical in current approaches and results in more comprehensive coverage of the conversational space. In addition, surveys demonstrate the acceptability of this approach by both educators and students.