LLukas22/scidocs huggingface dataset:
Is the Combination of Distal Pancreatectomy and Cytoreductive Surgery With HIPEC Reasonable?: Results of an International Multicenter Study.

OBJECTIVE
To report the morbidity and risk factors for overall complications and for pancreatic fistula (PF) after distal pancreatic resection (DP) during cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC).


SUMMARY BACKGROUND DATA
The safety of DP in patients with peritoneal surface malignancies treated by CRS and HIPEC has been debated. The risk of PF and its impact on surgical outcomes are not well defined.


METHODS
Between 2001 and 2012, 118 patients with peritoneal surface malignancy undergoing CRS/HIPEC required DP at 7 oncological surgical centers. The incidence, clinical impact, and risk factors of PF were analyzed.


RESULTS
The indications for DP were tumoral invasion of the pancreatic gland with (n = 24; 20%) or without splenic extension (n = 76; 64%), invasion of the pancreatic capsule (n = 10; 9%), or iatrogenic lesions during CRS (n = 8; 7%). The rate of 90 days postoperative mortality was 7.6%, and the rate of severe morbidity (Clavien-Dindo ≥III) was 44%. Pancreatic fistula was observed in 39 cases (33%), with the majority grade B (48.7%) or C (28.2%). In multivariate analysis, the risk factors for PF were a peritoneal cancer index more than 20 (risk ratio: 3.01; P = 0.022) and an operative time more than 550 min (risk ratio: 2.74; P = 0.038). The occurrence of PF was not associated with a higher risk of 90-day mortality (5.1% vs 8.8%, not significant).


CONCLUSIONS
With regard to reported morbi-mortality rates, DP associated with CRS/HIPEC may be a reasonable procedure in highly selected patients when done in high-volume centers. Therefore, distal pancreatic involvement should not be considered as a definitive contraindication for CRS/HIPEC in patients with resectable peritoneal surface disease.
Internet of Things for Industrial Automation -- Challenges and Technical Solutions

Using internet of things (IoT) to connect things, service, and people for intelligent operations has been discussed and deployed in many industry domains such as smart city, smart energy, healthcare, food and water tracking, logistics and retail, and transportation. However, scarce information is available for IoT usage in industrial automation domain for reliable and collaborative automation with respect to e.g., enabling scalable collaboration between heterogeneous devices and systems, offering predictable and fault-tolerant real-time closed-loop control, and inclusion of intelligent service features from edge devices to the cloud. In this paper, we will clarify the specific quality attribute constraints within industrial automation, present specific industrial IoT challenges due to these constraints, and discuss the potentials of utilizing some technical solutions to cope with these challenges.
Cerebrolysin combined with rehabilitation promotes motor recovery in patients with severe motor impairment after stroke.

BACKGROUND
Cerebrolysin is a neuropeptide preparation with neuroprotective and neurorestorative effects. Combining Cerebrolysin treatment with a standardized rehabilitation program may have a potential synergistic effect in the subacute stage of stroke. This study aims to evaluate whether Cerebrolysin provides additional motor recovery on top of rehabilitation therapy in the subacute stroke patients with moderate to severe motor impairment.


METHODS
This phase IV trial was designed as a prospective, multicenter, randomized, double-blind, placebo-controlled, parallel-group study. A total of 70 patients (Cerebrolysin n = 35, placebo n = 35) with moderate to severe motor function impairment were included within 7 days after stroke onset and were randomized to receive a 21-day treatment course of either Cerebrolysin or placebo, given in addition to standardized rehabilitation therapy. Assessments were performed at baseline, immediately after treatment as well as 2 and 3 months after stroke onset. The plasticity of motor system was assessed by diffusion tensor imaging and with resting state functional magnetic resonance imaging.


RESULTS
Both groups demonstrated significant improvement in motor function (p < 0.05); however, no significant difference was found between the two groups. In the stroke patients with severe motor impairment, the Cerebrolysin group exhibited significantly more improvement in motor function compared with the placebo group (p < 0.05). Effects of Cerebrolysin were demonstrated as restricted increments of corticospinal diffusivity and as recovery of the sensorimotor connectivity.


CONCLUSION
The combination of standard rehabilitation therapy with Cerebrolysin treatment in the subacute stroke has shown additional benefit on motor recovery and plastic changes of the corticospinal tract in patients with severe motor impairment.


TRIAL REGISTRATION
NCT01996761 (November 5, 2013).
Introduction to Robotics: Mechanics and Control

How can you change your mind to be more open? There many sources that can help you to improve your thoughts. It can be from the other experiences and also story from some people. Book is one of the trusted sources to get. You can find so many books that we share here in this website. And now, we show you one of the best, the introduction to robotics mechanics and control john j craig solution manual.
Diagnostic dilemma in vascular mal-formation of the upper lip: a case report and review of literature

This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 License (http://creativecommons.org/licenses/by-nc-sa/3.0/) which permits unrestricted, non-commercial, share-alike use, distribution, and reproduction in any medium, provided the original work is properly cited. Diagnostic dilemma in vascular mal-formation of the upper lip: a case report and review of literature
Emotional intelligence , Machiavellianism and emotional manipulation : Does EI have a dark side ?

Associations of Machiavellianism (Mach) with self-report and performance emotional intelligence (EI) and with personality were examined. The possible existence of an emotional manipulation capability, not covered within current EI measures, was also examined by constructing an emotional manipulation scale. Mach was found to be negatively correlated with self-report and performance EI, and also with Agreeableness and Conscientiousness. Emotional manipulation was positively correlated with Mach but unrelated to EI. Thus high Machs endorse emotionally-manipulative behaviour, although the extent to which they are successful in this behaviour, given the negative Mach/EI association, remains to be established. 2006 Published by Elsevier Ltd.
An integrated 77-GHz six-port receiver front-end for angle-of-arrival detection

In this publication an integrated six-port receiver front-end for angle-of-arrival detection of 77-GHz signals is presented. Applications of the circuit are direction finding, auto-motive radar calibration, or high precision industrial radar. The measurement principle is based on superposition of two incident signals and power detection. The circuit has two input amplifiers, a broadband passive six-port network, and four power detectors. The integrated circuit has a power consumption of 95mW with 5V supply voltage. It is fabricated in a 200-GHz fT SiGe bipolar technology and occupies only 1028 × 1128 µm2. Functionality is demonstrated by applying two different frequencies at the input ports. A simple calibration method is proposed and all calibration parameters are calculated.
Experiencing Rare and Unusual Events Richly: The Role of Middle Managers in Animating and Guiding Organizational Interpretation

Organizations have difficulty learning from rare and unusual events because of their inability to interpret these events. Because organizations develop habitual ways of interpreting events—often top down—they can easily miss the novelty of rare and unusual events, which prevents them from experiencing events “richly.” We propose a multilevel, multistaged model of organizational interpretation that highlights the important, but generally unacknowledged, role middle managers can play in helping organizations experience rare and unusual events richly. Our model accounts for the effect of cognitive biases and hierarchical context on organizational interpretation. Because of their proximity to the interpretations of both strategic and front-line managers, middle managers can encourage divergence in interpretations of managers across hierarchical levels during early stages of the interpretation process and can blend and synthesize the divergent interpretations of managers during later stages. In this way middle managers contribute to a dynamic process of organizational interpretation in which multiple filters from throughout the organization help frame and enrich interpretations of rare and unusual events, which enables organizational learning.
Remote sensing and geomorphometry for studying relief production in high mountains

Mountain topography is the result of highly scale-dependent interactions involving climatic, tectonic, and surface processes. No complete understanding of the geodynamics of mountain building and topographic evolution yet exists, although numerous conceptual and physical models indicate that surficial erosion plays a significant role. Mapping and assessing landforms and erosion in mountain environments is essential in order to understand landscape denudation and complex feedback mechanisms. This requires the development and evaluation of new approaches in remote sensing and geomorphometry. The research herein evaluates the problem of topographic normalization of satellite imagery and demonstrates the use of terrain analysis using a digital elevation model (DEM) to evaluate the relief structure of the landscape in the western Himalaya. We specifically evaluated the Cosine-correction and Minnaert-correction methods to reduce spectral variation in imagery caused by the topography. Semivariogram analyses of the topography were used to examine the relationships between relief and surface processes. Remote-sensing results indicate that the Minnaert-correction method can be used to reduce the ‘‘topographic effect’’ in satellite imagery for mapping, although extreme radiance values are the result of not accounting for the diffuse-skylight and adjacent-terrain irradiance. Geomorphometry results indicate that river incision and glaciation can generate extreme relief, although the greatest mesoscale relief is produced by glaciation at high altitudes. At intermediate altitudes, warm-based glaciation was found to decrease relief. Our results indicate that glaciation can have a differential influence on the relief structure of the landscape. Collectively, our results indicate that scale-dependent analysis of the topography is required to address radiation transfer issues and the polygenetic nature of landscape denudation and relief production. D 2003 Elsevier B.V. All rights reserved.
Totally extraperitoneal (TEP) bilateral hernioplasty using the Single Site® robotic da Vinci platform (DV-SS TEP): description of the technique and preliminary results

Laparoendoscopic single site totally extraperitoneal (TEP) hernia repair showed to be a feasible alternative to conventional laparoscopic hernia repair; nevertheless single site surgery, with the loss of instruments triangulation can be a demanding procedure. To overcome those hurdles, the Single Site® (SS) platform of the da Vinci (DV) Si robotic system enables to perform surgical procedures through a 25-mm skin incision, with a stable 3D vision and restoring an adequate triangulation of the surgical instruments. We present in details the technique and the preliminary results of DV-SS TEP, to our knowledge the first cases reported in literature. In March 2016, three consecutive male patients (mean age 46.6 years–mean BMI 25.3) with bilateral symptomatic inguinal hernia were submitted to DV-SS TEP in our institutions. Feasibility, codification of the technique, operative time and perioperative outcomes were recorded. All the procedures were completed as scheduled, with no conversion to other techniques. Mean operative time was 98.6 min, ranging between 155 and 55 min, reflecting the learning curve of the operating room team on this new procedure. No intraoperative or postoperative complications were experienced and all the patients were discharged within 24 h after surgery. Patients reported satisfactory postoperative course, with no recurrence of inguinal hernia and satisfaction in cosmetic result at 6-month follow-up. DV-SS TEP inguinal hernia repair showed to be feasible and effective surgical option for bilateral groin hernia repair. Patients’ outcome was uneventful, with optimal cosmetic results. Further studies comparing this innovative technique to TEP or LESS TEP should be promoted.
Tumor marker and measurement fluctuations may not reflect treatment efficacy in patients with medullary thyroid carcinoma on long-term RET inhibitor therapy.

BACKGROUND
RET kinase inhibitors have significant activity in patients with medullary thyroid carcinoma (MTC).


PATIENTS AND METHODS
We retrospectively reviewed the electronic medical record for patterns of calcitonin, carcinoembryonic antigen (CEA) and tumor measurement responses in consecutive patients with MTC who received treatment with a RET inhibitor for at least 6 months.


RESULTS
Twenty-six patients who received RET kinase inhibitors for at least 6 months were included. All patients experienced an initial decline in calcitonin; 20 (77%) demonstrated later fluctuations in calcitonin, which spiked above baseline levels in 9 individuals (35%). Twenty of the 22 patients (91%) with elevated CEA experienced a decline with treatment, with 11 individuals (50%) later demonstrating transient fluctuations in CEA, including spikes above baseline in 7 patients (32%). Ten of the 26 patients (38%) also demonstrated short-lived fluctuations in RECIST measurements, including changes of over 20% from nadir values. Vacillations in calcitonin, CEA and measurements often occurred repeatedly in individual patients and did not regularly correlate with each other.


CONCLUSIONS
Repeated transient fluctuations in tumor markers and measurements are a characteristic of patients with MTC receiving treatment with RET inhibitors, and such short-term vacillations may not reflect responsiveness over the long term.


CLINICAL TRIALS INCLUDED
NCT00215605; NCT00244972; NCT00121680; NCT00495872.
Reliability testing of the patellofemoral joint reaction force (PFJRF) measurement during double-legged squatting in healthy subjects: a pilot study.

INTRODUCTION
Anterior knee pain or patellofemoral pain syndrome (PFPS) is supposed to be related to patellofemoral joint reaction forces (PFJRF). Measuring these forces may therefore provide reliable evidence for conservative treatments to correct probable malalignment in subjects with PFPS. The aim of the present study was to examine the reliability of PFJRF measurements during double-legged squatting in healthy subjects.


METHODS
Using a motion analysis system and one forceplate, PFJRF of 10 healthy subjects were assessed during double-legged squatting. Data were collected from superficial markers taped to selected landmarks. This procedure was performed on the right knees, at three different knee flexion angles of 30, 45 and 60° during three separate double-legged squats. Subjects were then requested to repeat this test procedure on two separate test sessions at different occasions. The PFJRF was calculated using a biomechanical model of the patellofemoral joint.


RESULTS
The data reveal an increase in PFJRF values (from mean, SD of 425.2, 35.5N to 1075.4, 70.1N)with an increase in the tibiofemoral joint angle during double-legged squatting. The CV (coefficient of variation) values during within and between session tests, revealed the high repeatability and reproducibility of PFJRF measurements, while the ICC (intra class correlation coefficient) values showed the low reliability of these measurements.


CONCLUSION
The low reliability of PFJRF measurements suggests that the PFJRF measurement during double-legged squatting should be performed with caution with improving the method of kinetic measurement of the patellofemoral joint in healthy subjects.
Effect of different ferrule designs on the fracture resistance and
failure pattern of endodontically treated teeth restored with fiber posts and
allceramic crowns

OBJECTIVE
This study investigated the effect of different ferrule heights on endodontically treated premolars.


MATERIAL AND METHODS
Fifty sound mandibular first premolars were endodontically treated and then restored with 7-mm fiber post (FRC Postec Plus #1 Ivoclar-Vivadent) luted with self-polymerized resin cement (Multilink, Ivoclar Vivadent) while the coronal section was restored with hybrid composite core build-up material (Tetric Ceram, Ivoclar-Vivadent), which received all-ceramic crown. Different ferrule heights were investigated: 1-mm circumferential ferrule without post and core (group 1 used as control), a circumferential 1-mm ferrule (group 2), non-uniform ferrule 2-mm buccally and 1-mm lingually (group 3), non-uniform ferrule 3-mm buccally and 2-mm lingually (group 4), and finally no ferrule preparation (group 5). The fracture load and failure pattern of the tested groups were investigated by applying axial load to the ceramic crowns (n=10). Data were analyzed statistically by one-way ANOVA and Tukey's post-hoc test was used for pair-wise comparisons (α=0.05).


RESULTS
There were no significant differences among the failure load of all tested groups (P<0.780). The control group had the lowest fracture resistance (891.43 ± 202.22 N) and the highest catastrophic failure rate (P<0.05). Compared to the control group, the use of fiber post reduced the percentage of catastrophic failure while increasing the ferrule height did not influence the fracture resistance of the restored specimens.


CONCLUSIONS
Within the limitations of this study, increasing the ferrule length did not influence the fracture resistance of endodontically treated teeth restored with glass ceramic crowns. Insertion of a fiber post could reduce the percentage of catastrophic failure of these restorations under function.
Screening for childhood mental health disorders using the Strengths and Difficulties Questionnaire: the validity of multi-informant reports.

AIM
This study investigated the diagnostic accuracy of the Strengths and Difficulties Questionnaire (SDQ) in a population of children born extremely preterm (<26wks gestation).


METHOD
Parents and teachers of 219 extremely preterm children (118 females, 101 males; age 11y) were asked to complete the SDQ to screen for psychological problems. Multi-informant ratings were aggregated using two methods: combined (parent or teacher rated the child with problems) and pervasive (parent and teacher rated the child with problems). Psychiatric diagnoses were assigned using the Development and Well-Being Assessment.


RESULTS
Pervasive ratings had the greatest diagnostic accuracy for emotional disorders (89%), conduct disorders (94%), attention-deficit-hyperactivity disorder (ADHD; 90%), and autism spectrum disorders (ASDs; 94%), but were associated with low sensitivity (≤50%). For clinical use, combined ratings were best for detecting emotional disorders (sensitivity 77%, specificity 75%), conduct disorders (83%, 88%), and ADHD (85%, 72%). Parent ratings were best for ASDs (93%, 66%). Teacher ratings significantly improved prediction over parent ratings alone for conduct disorders (∆χ(2) =9.3, p=0.002) and ADHD (∆χ(2) =24.1, p<0.001) only.


INTERPRETATION
Multi-informant data are preferable for assessing most mental health outcomes using the SDQ. As an outcome measure, pervasive ratings have the best predictive accuracy. For screening, combined ratings are best for detecting ADHD and emotional and conduct disorders. For ASDs, parent ratings were best.
Excellent outcome with reduced treatment in infants with nonmetastatic and unresectable neuroblastoma without MYCN amplification: results of the prospective INES 99.1.

PURPOSE
To evaluate the efficacy of low-dose chemotherapy in infants with nonmetastatic and unresectable neuroblastoma (NB) without MYCN amplification.


PATIENTS AND METHODS
Infants with localized NB and no MYCN amplification were eligible in the SIOPEN Infant Neuroblastoma European Study 99.1 study. Primary tumor was deemed unresectable according to imaging defined risk factors. Diagnostic procedures and staging were carried out according to International Staging System recommendations. Children without threatening symptoms received low-dose cyclophosphamide (5 mg/kg/d × 5 days) and vincristine (0.05 mg/kg at day 1; CyV), repeated once to three times every 2 weeks until surgical excision could be safely performed. Children with either one threatening symptom or insufficient response to CyV were given carboplatin and etoposide (CaE), sometimes followed by vincristine, cyclophosphamide, and doxorubicin. No postoperative treatment was to be administered.


RESULTS
Between December 1999 and April 2004, 120 infants were included in the study. Eighty-eight had no threatening symptoms and 79 received CyV. CaE was given to 49 of them because of insufficient response. Thirty-two children had threatening symptoms, 30 of whom received CaE. Anthracyclines were given to 46 children. Surgery was attempted in 102 patients, leading to gross surgical excision in 93. Relapse occurred in 12 patients (nine local and three metastatic). Five-year overall and event-free survivals were 99% ± 1% and 90% ± 3%, respectively, with a median follow-up of 6.1 years (range, 1.6 to 9.1).


CONCLUSION
Low-dose chemotherapy without anthracyclines is effective in 62% of infants with an unresectable NB and no MYCN amplification, allowing excellent survival rates without jeopardizing their long-term outcome.
In-Flight Entertainment System: State of the Art and Research Directions

The enclosed environment of the aircraft causes both physiological and psychological discomfort and even negative stress. In-flight entertainment systems are commonly installed on the long-haul aircrafts to increase the passenger's comfort level. In this paper, we first check how the current in-flight entertainment systems are designed and implemented to improve the passenger's comfort level. Then, we investigate the state of the art of related systems and enabling technologies that could enable a new context-adaptive system to provide personalized entertainment services to reduce the passenger's physical and psychological negative stress intelligently and effectively. Finally, we conclude with possible research directions towards this goal.