LLukas22/scidocs huggingface dataset:
Protocol for a randomised controlled trial investigating the effectiveness of an online e health application for the prevention of Generalised Anxiety Disorder

BACKGROUND
Generalised Anxiety Disorder (GAD) is a highly prevalent psychiatric disorder. Effective prevention in young adulthood has the potential to reduce the prevalence of the disorder, to reduce disability and lower the costs of the disorder to the community. The present trial (the WebGAD trial) aims to evaluate the effectiveness of an evidence-based online prevention website for GAD.


METHODS/DESIGN
The principal clinical question under investigation is the effectiveness of an online GAD intervention (E-couch) using a community-based sample. We examine whether the effect of the intervention can be maximised by either human support, in the form of telephone calls, or by automated support through emails. The primary outcome will be a reduction in symptoms on the GAD-7 in the active arms relative to the non active intervention arms.


DISCUSSION
The WebGAD trial will be the first to evaluate the use of an internet-based cognitive behavioural therapy (CBT) program contrasted with a credible control condition for the prevention of GAD and the first formal RCT evaluation of a web-based program for GAD using community recruitment. In general, internet-based CBT programs have been shown to be effective for the treatment of other anxiety disorders such as Post Traumatic Stress Disorder, Social Phobia, Panic Disorder and stress in clinical trials; however there is no evidence for the use of internet CBT in the prevention of GAD. Given the severe shortage of therapists identified in Australia and overseas, and the low rates of treatment seeking in those with a mental illness, the successful implementation of this protocol has important practical outcomes. If found to be effective, WebGAD will provide those experiencing GAD with an easily accessible, free, evidence-based prevention tool which can be promoted and disseminated immediately.
Sleep deprivation and drowsiness of medical residents and medical students.

OBJECTIVE
to evaluate sleep quality and daytime sleepiness of residents and medical students.


METHODS
we applied a socio-demographic questionnaire, the Pittsburgh Sleep Quality Index (PSQI) and the Epworth Sleepiness Scale (ESS) to a population of residents and medical students.


RESULTS
hundred five residents and 101 undergraduate medical students participated. Residents presented higher mean PSQI (6.76±2.81) with poorer sleep quality when compared with undergraduates (5.90±2.39); Both had similar measures of sleepiness by ESS (p=0.280), but residents showed lower duration and lower subjective sleep quality.


CONCLUSION
medical students and residents presented sleep deprivation, indicating the need for preventive actions in the medical area.
Ocean Ridge Granite and Its Geochemical Characteristics in Western Qinghai—Xizang Plateau

In our work, ocean ridge granite, i.e., Oytag plagiogranite massif, was discovered in western Qinghai-Xizang plateau. It intruded into the basic lava of the Oytag ophiolite suite and it was formed a little later than the (ultra) mafic rocks of the Oytag ophiolite suite. The Oytag plagiogranite possesses the geochemical characteristics of mantle-source granite and was formed in the "supra-subduction zone" (SSZ) ocean ridge environment, like the ocean ridge granite of Troodos, Cypus.
A randomized controlled trial of a self-regulation intervention for older adults with asthma.

OBJECTIVES
To evaluate a self-regulation intervention for asthma for older adults.


DESIGN
A blinded randomized controlled trial.


SETTING
Single-center tertiary care academic center.


PARTICIPANTS
Seventy older adults aged 65 and older with persistent asthma randomized to an intervention or control group.


INTERVENTION
Participants participate in a six-session program conducted over the telephone and in group sessions. Participants selected an asthma-specific goal, identified problems, and addressed potential barriers.


MEASUREMENTS
Outcomes were assessed at 1, 6, and 12 months and included the mini-Asthma Quality of Life Questionnaire (mAQLQ), Asthma Control Questionnaire (ACQ), healthcare utilization, exhaled nitric oxide (FENO), and percentage of predicted forced expiratory volume in 1 second (FEV1%).


RESULTS
The mAQLQ score was significantly higher in the intervention group at 1, 6, and 12 months, even after controlling for confounding factors. The between-group difference decreased over time, although at 12 months, it remained greater than 0.5 points. The ACQ was better in the intervention group than in the control group at 1, 6, and 12 months. At 12 months, those in the intervention group were 4.2 times as likely as those in the control group to have an ACQ score in the controlled range. Healthcare utilization was lower in the intervention group, although no difference was observed in FENO or predicted FEV1%.


CONCLUSION
A self-regulation intervention can improve asthma control, quality of life, and healthcare utilization in older adults.
Adherence with immunosuppression in heart transplant recipients.

PURPOSE OF REVIEW
Nonadherence is a major problem in heart transplantation (htx) and a challenge for clinical practice and research. In heart transplant recipients, nonadherence could cause chronic rejection of the transplanted heart followed by difficult clinical course and/or death of the patient.


RECENT FINDINGS
Main topics are the relationship between psychological aspects and adherence, risk factors and prediction of nonadherence, strategies for improving adherence like single-dose immunosuppressant therapy and follow-up studies.


SUMMARY
There is a lack of behavioral intervention studies. So-called targeted interventions should be defined for clinical practice and research with randomized controlled studies.
Greedy routing with guaranteed delivery using Ricci flows

Greedy forwarding with geographical locations in a wireless sensor network may fail at a local minimum. In this paper we propose to use conformal mapping to compute a new embedding of the sensor nodes in the plane such that greedy forwarding with the virtual coordinates guarantees delivery. In particular, we extract a planar triangulation of the sensor network with non-triangular faces as holes, by either using the nodes' location or using a landmark-based scheme without node location. The conformal map is computed with Ricci flow such that all the non-triangular faces are mapped to perfect circles. Thus greedy forwarding will never get stuck at an intermediate node. The computation of the conformal map and the virtual coordinates is performed at a preprocessing phase and can be implemented by local gossip-style computation. The method applies to both unit disk graph models and quasi-unit disk graph models. Simulation results are presented for these scenarios.
Workload State Classification With Automation During Simulated Air Traffic Control

Real-time operator workload assessment and state classification may be useful for decisions about when and how to dynamically apply automation to information processing functions in aviation systems. This research examined multiple cognitive workload measures, including secondary task performance and physiological (cardiac) measures, as inputs to a neural network for operator functional state classification during a simulated air traffic control (ATC) task. Twenty-five participants performed a low-fidelity simulation under manual control or 1 of 4 different forms of automation. Traffic volume was either low (3 aircraft) or high (7 aircraft). Participants also performed a secondary (gauge) monitoring task. Results demonstrated significant effects of traffic volume (workload) on aircraft clearances (p < .01) and trajectory conflicts (p < .01), secondary task performance (p < .01), and subjective ratings of task workload (p < .01). The form of ATC automation affected the number of aircraft collisions (p < .05), secondary task performance (p < .01), and heart rate (HR; p < .01). However, heart rate and heart rate variability measures were not sensitive to the traffic manipulation. Neural network models of controller workload (defined in terms of traffic volume) were developed using the secondary task performance and simple heart rate measure as inputs. The best workload classification accuracy using a genetic algorithm (across all forms of ATC automation) was 64%, THE INTERNATIONAL JOURNAL OF AVIATION PSYCHOLOGY, 17(4), 371–390 Copyright © 2007, Lawrence Erlbaum Associates, Inc.
Purified Human Synovium Mesenchymal Stem Cells as a Good Resource for Cartilage Regeneration

Mesenchymal stem cells (MSCs) have the ability to differentiate into a variety of lineages and to renew themselves without malignant changes, and thus hold potential for many clinical applications. However, it has not been well characterized how different the properties of MSCs are depending on the tissue source in which they resided. We previously reported a novel technique for the prospective MSC isolation from bone marrow, and revealed that a combination of cell surface markers (LNGFR and THY-1) allows the isolation of highly enriched MSC populations. In this study, we isolated LNGFR(+) THY-1 (+) MSCs from synovium using flow cytometry. The results show that the synovium tissue contained a significantly larger percentage of LNGFR (+) THY-1 (+) MSCs. We examined the colony formation and differentiation abilities of bone marrow-derived MSCs (BM-MSCs) and synovium-derived MSCs (SYN-MSCs) isolated from the same patients. Both types of MSCs exhibited a marked propensity to differentiate into specific lineages. BM-MSCs were preferentially differentiated into bone, while in the SYN-MSC culture, enhanced adipogenic and chondrogenic differentiation was observed. These data suggest that the tissue from which MSCs are isolated should be tailored according to their intended clinical therapeutic application.
Impact of diuretic dosing on mortality in acute heart failure using a propensity-matched analysis.

AIMS
Loop diuretics are recommended to treat congestion in heart failure (HF), despite limited quality evidence. High-dose (HD) loop diuretics seem to worsen outcomes in chronic HF, though; data for acute HF are scarce, with equivocal results.


METHODS AND RESULTS
The ALARM-HF study recorded in-hospital HF therapy in 4953 patients from nine countries. A post-hoc analysis was performed to determine if there was an interaction between intravenous (iv) bolus diuretic dosing and outcomes. Patients were classified as receiving high- or low-dose iv furosemide if their total initial 24 h dose was above (HD) or below [low dose (LD)] 1 mg/kg. Propensity scoring, matching an extensive list of variables, was performed. High-dose and LD patients were matched by propensity scores and outcomes determined. We identified 2460 LD and 848 HD patients, with overall in-hospital mortality of 9 and 13% (P= 0.002), respectively. After propensity matching, there were 506 patients in each subgroup, with the matched LD and HD cohorts having similar mortality (13 vs. 15%; P= 0.4). We further investigated in which subgroups of patients HD diuretics influenced mortality. Before matching, HD diuretics were associated with a greater risk of in-hospital death in some subgroups, including patients aged >80 years, those with an acute coronary syndrome, or with a left ventricular ejection fraction <40%. However, after propensity score matching, no association was found between diuretic dosing and death in any of the studied subgroups.


CONCLUSIONS
In the initial management of acute HF, HD iv diuretics, per se, do not influence short-term mortality.
HIV Incidence Remains High in KwaZulu-Natal, South Africa: Evidence from Three Districts

BACKGROUND
HIV prevalence and incidence among sexually active women in peri-urban areas of Ladysmith, Edendale, and Pinetown, KwaZulu-Natal, South Africa, were assessed between October 2007 and February 2010 in preparation for vaginal microbicide trials.


METHODOLOGY/PRINCIPAL FINDINGS
Sexually active women 18-35 years, not known to be HIV-positive or pregnant were tested cross-sectionally to determine HIV and pregnancy prevalence (798 in Ladysmith, 1,084 in Edendale, and 891 in Pinetown). Out of these, approximately 300 confirmed non-pregnant, HIV-negative women were subsequently enrolled at each clinical research center (CRC) in a 12-month cohort study with quarterly study visits. Women in the cohort studies were required to use a condom plus a hormonal contraceptive method. HIV prevalence rates in the baseline cross-sectional surveys were high: 42% in Ladysmith, 46% in Edendale and 41% in Pinetown. Around 90% of study participants at each CRC reported one sex partner in the last 3 months, but only 14-30% stated that they were sure that none of their sex partners were HIV-positive. HIV incidence rates based on seroconversions over 12 months were 14.8/100 person-years (PY) (95% CI 9.7, 19.8) in Ladysmith, 6.3/100 PY (95% CI 3.2, 9.4) in Edendale, and 7.2/100 PY (95% CI 3.7, 10.7) in Pinetown. The 12-month pregnancy incidence rates (in the context of high reported contraceptive use) were: 5.7/100 PY (95% CI 2.6, 8.7) in Ladysmith, 3.1/100 PY (95% CI 0.9, 5.2) in Edendale and 6.3/100 PY (95% CI 3.0, 9.6) in Pinetown.


CONCLUSIONS/SIGNIFICANCE
HIV prevalence and incidence remain high in peri-urban areas of KwaZulu-Natal.
Do Multinational Enterprises Substitute Parent Jobs for Foreign Ones ? Evidence from European Firm-Level Panel Data *

Do Multinational Enterprises Substitute Parent Jobs for Foreign Ones? Evidence from European Firm-Level Panel Data* This Paper analyses the demand for labour by home multinational enterprises (MNEs) in Europe. To this end we use a unique firm-level panel data set of more than 1,200 European multinational enterprises and their subsidiaries that are located in either the European Union, Central and Eastern Europe or both. We investigate whether employment in the MNEs’ subsidiaries is a substitute for home employment – in other words we investigate whether European MNEs can easily relocate employment between the parent companies and their subsidiaries. Our main findings can be summarized as follows: (i) We find evidence for substitution effects between parent and foreign employment. A decline of 10% in MNE affiliate’s wage costs is associated with a decline in parent employment of between 1.5% and 2% on average. (ii) This effect is mainly driven by firms that operate in the manufacturing sector. Moreover, the substitution effects mainly take place between EU parents and their affiliates located within the EU, rather than affiliates located in Central and Eastern Europe. (iii) We also report results for non-manufacturing firms – we find no substitution effects between parents and subsidiaries in the service sectors, while we do find positive substitution effects between parents and their affiliates in Central and Eastern Europe for firms operating in the wholesale trade and construction sectors. Our results suggest that on average the competition from low wage countries in Central and Eastern Europe does not contribute to a relocation of domestic jobs to Central and Eastern Europe. When substitution effects do take place, however, they mainly occur between parent firms and their affiliates that are located in the European Union. JEL Classification: F23 and J23
Deep Learning Earth Observation Classification Using ImageNet Pretrained Networks

Deep learning methods such as convolutional neural networks (CNNs) can deliver highly accurate classification results when provided with large enough data sets and respective labels. However, using CNNs along with limited labeled data can be problematic, as this leads to extensive overfitting. In this letter, we propose a novel method by considering a pretrained CNN designed for tackling an entirely different classification problem, namely, the ImageNet challenge, and exploit it to extract an initial set of representations. The derived representations are then transferred into a supervised CNN classifier, along with their class labels, effectively training the system. Through this two-stage framework, we successfully deal with the limited-data problem in an end-to-end processing scheme. Comparative results over the UC Merced Land Use benchmark prove that our method significantly outperforms the previously best stated results, improving the overall accuracy from 83.1% up to 92.4%. Apart from statistical improvements, our method introduces a novel feature fusion algorithm that effectively tackles the large data dimensionality by using a simple and computationally efficient approach.
Research Challenges for Data Mining in Science and Engineering

With the rapid development of computer and information technology in the last several decades, an enormous amount of data in science and engineering has been and will continuously be generated in massive scale, either being stored in gigantic storage devices or flowing into and out of the system in the form of data streams. Moreover, such data has been made widely available, e.g., via the Internet. Such tremendous amount of data, in the order of terato petabytes, has fundamentally changed science and engineering, transforming many disciplines from data-poor to increasingly data-rich, and calling for new, data-intensive methods to conduct research in science and engineering. In this paper, we discuss the research challenges in science and engineering, from the data mining perspective, with a focus on the following issues: (1) information network analysis, (2) discovery, usage, and understanding of patterns and knowledge, (3) stream data mining, (4) mining moving object data, RFID data, and data from sensor networks, (5) spatiotemporal and multimedia data mining, (6) mining text, Web, and other unstructured data, (7) data cube-oriented multidimensional online analytical mining, (8) visual data mining, and (9) data mining by integration of sophisticated scientific and engineering domain knowledge.
Comparison of navigated and non-navigated transcranial magnetic stimulation for motor cortex mapping, motor threshold and motor evoked potentials

Transcranial magnetic stimulation (TMS) can be used for non-invasive assessment of cortical physiology and descending motor pathways. However, the focus/exact site of cortical activation is considerably widespread in traditional TMS. When combined with MRI-based navigation, it allows specific anatomical areas of the cortex to be stimulated. The peripheral muscle responses to TMS are commonly measured as motor evoked potentials (MEPs). We compared the accuracy of cortical mapping, as well as the congruity of the motor thresholds (MT) and MEPs between navigated and non-navigated TMS procedures. Eight volunteers were studied in two sessions. In each session both hemispheres were stimulated with and without navigation. Non-navigated TMS: Both hemispheres were mapped without navigation to find the representation area of the thenar muscles based on induced MEP amplitudes. MT was then determined at the optimum coil location. Navigated TMS: Individual MR-images were used for the on-line navigation procedure. The cortical representation area of the thenar musculature was mapped at the "hand knob". The optimum stimulus target was used for MT determination. The order of these two procedures was randomized. Following the MT determination, MEPs were recorded from 20 consecutive stimuli. The MTs were similar from session-to-session with no inter-hemispheric differences, and with and without navigation. The stimulus location was more spatially discrete in navigated TMS producing more stable MEPs with significantly higher amplitudes and shorter latencies. In summary, MEPs exhibit significant differences depending on whether navigation is used. However, the MTs are not significantly dependent on the discrete stimulation site.
Review of 'Innovations in Participatory Politics' by B. Loader and D. Mercea, eds.

Brian Loader and Dan Mercea rally a group of political/social/media scientists to shed light on social media and democracy. Is social media supporting transformations of democratic power or merely inspiring the latest round of cyber-utopian hype? Current developments in democracy are investigated, in recent Internet contexts, more or less in the context of social media.
The emotional deficits associated with the Dark Triad traits : cognitive empathy, affective empathy, and alexithymia

Volunteers (N = 322) in an online survey revealed the complex correlational patterns between the Dark Triad traits and two forms of ‘‘emotional deficiencies’’ (i.e., limited empathy and alexithymia) overall and in each sex. Each Dark Triad trait was associated with a unique pattern of emotional deficits. Psychopathy was correlated with limited overall empathy, difficulty describing feelings, and externally oriented thinking. Narcissism was associated with limited affective empathy and difficulty identifying feelings, whereas Machiavellianism was associated with externally oriented thinking. The Dark Triad mediated sex differences in empathy and externally oriented thinking. Structural Equation Modeling suggests that the differential facets of alexithymia predict different forms of limited empathy that in turn predict specific Dark Triad traits. Results are discussed using an evolutionary paradigm. 2013 Elsevier Ltd. All rights reserved.