LLukas22/scidocs huggingface dataset:
Enterprise agility and the enabling role of information technology

Received: 18 May 2005 Revised: 19 June 2005 Accepted: 9 January 2006 Abstract In turbulent environments, enterprise agility, that is, the ability of firms to sense environmental change and respond readily, is an important determinant of firm success. We define and deconstruct enterprise agility, delineate enterprise agility from similar concepts in the business research literature, explore the underlying capabilities that support enterprise agility, explicate the enabling role of information technology (IT) and digital options, and propose a method for measuring enterprise agility. The concepts in this paper are offered as foundational building blocks for the overall research program on enterprise agility and the enabling role of IT. European Journal of Information Systems (2006) 15, 120–131. doi:10.1057/palgrave.ejis.3000600
Relative adrenal insufficiency in dogs with sepsis.

BACKGROUND
A syndrome of relative adrenal insufficiency has been identified in septic humans, and is associated with hypotension and death. Relative adrenal insufficiency is generally associated with basal serum cortisol concentration within or above the reference range and a blunted cortisol response to adrenocorticotropic hormone administration. It is unknown whether relative adrenal insufficiency occurs in septic dogs.


HYPOTHESIS
That relative adrenal insufficiency occurs in septic dogs, and that relative adrenal insufficiency is associated with hypotension and mortality.


ANIMALS
Thirty-three septic dogs admitted to a small animal intensive care unit.


METHODS
Dogs were included in the study if they had a known or suspected infectious disease and had systemic inflammatory response syndrome. Dogs were excluded if they had disease or medication history expected to affect the hypothalamic-pituitary-adrenal axis. Serum cortisol and endogenous plasma adrenocorticotropic hormone concentrations were measured before, and serum cortisol concentration measured 1 hour after, intramuscular administration of 250 microg of cosyntropin/dog. The change in cortisol concentration (delta-cortisol) before and after cosyntropin administration was determined in each dog.


RESULTS
Hypotension was associated with lower delta-cortisol values (OR 1.3; CI 1.0-1.9; P = .029). delta-Cortisol cutoff of 3.0 microg/dL was most accurate for predicting hypotension, survival to discharge, and 28-day survival. The rate of death in dogs with delta-cortisol < or = 3 microg/dL was 4.1 times that of dogs with delta-cortisol > 3 microg/dL (RR 4.1; CI 1.5-12.3; P = .01).


CONCLUSIONS AND CLINICAL RELEVANCE
Delta-cortisol < or = 3 microg/dL after adrenocorticotropic hormone administration is associated with systemic hypotension and decreased survival in septic dogs.
Towards a Dynamic Theory of Strategy – Michael Porter (SMJ 1991)

• Develop and implement an internally consistent set of goals and functional policies (this is, a solution to the agency problem) • These internally consistent set of goals and policies aligns the firm’s strengths and weaknesses with external (industry) opportunities and threats (SWOT) in a dynamic balance • The firm’s strategy has to be concerned with the exploitation of its “distinctive competences” (early reference to RBV)
System usage behavior as a proxy for user satisfaction: an empirical investigation

Organizations are increasingly recognizing that user satisfaction with information systems is one of the most important determinants of the success of those systems. However, current satisfaction measures involve an intrusion into the users' worlds, and are frequently deemed to be too cumbersome to be justi®ed ®nancially and practically. This paper describes a methodology designed to solve this contemporary problem. Based on theory which suggests that behavioral observations can be used to measure satisfaction, system usage statistics from an information system were captured around the clock for 6 months to determine users' satisfaction with the system. A traditional satisfaction evaluation instrument, a validated survey, was applied in parallel, to verify that the analysis of the behavioral data yielded similar results. The ®nal results were analyzed statistically to demonstrate that behavioral analysis is a viable alternative to the survey in satisfaction measurement. # 1999 Elsevier Science B.V. All rights reserved.
Annotating Opinions in the World Press

In this paper we present a detailed scheme for annotating expressions of opinions, beliefs, emotions, sentiment and speculation (private states) in the news and other discourse. We explore inter-annotator agreement for individual private state expressions, and show that these low-level annotations are useful for producing higher-level subjective sentence annotations.
A Mathematical Model of the Effect of Immunogenicity on Therapeutic Protein Pharmacokinetics

A mathematical pharmacokinetic/anti-drug-antibody (PK/ADA) model was constructed for quantitatively assessing immunogenicity for therapeutic proteins. The model is inspired by traditional pharmacokinetic/pharmacodynamic (PK/PD) models, and is based on the observed impact of ADA on protein drug clearance. The hypothesis for this work is that altered drug PK contains information about the extent and timing of ADA generation. By fitting drug PK profiles while accounting for ADA-mediated drug clearance, the model provides an approach to characterize ADA generation during the study, including the maximum ADA response, sensitivity of ADA response to drug dose level, affinity maturation rate, time lag to observe an ADA response, and the elimination rate for ADA–drug complex. The model also provides a mean to estimate putative concentration–time profiles for ADA, ADA–drug complex, and ADA binding affinity-time profile. When simulating ADA responses to various drug dose levels, bell-shaped dose–response curves were generated. The model contains simultaneous quantitative modeling and provides estimation of the characteristics of therapeutic protein drug PK and ADA responses in vivo. With further experimental validation, the model may be applied to the simulation of ADA response to therapeutic protein drugs in silico, or be applied in subsequent PK/PD models.
Closed Kinetic Chain Upper Extremity Stability test (CKCUES test): a reliability study in persons with and without shoulder impingement syndrome

BACKGROUND
The Close Kinetic Chain Upper Extremity Stability Test (CKCUES test) is a low cost shoulder functional test that could be considered as a complementary and objective clinical outcome for shoulder performance evaluation. However, its reliability was tested only in recreational athletes' males and there are no studies comparing scores between sedentary and active samples. The purpose was to examine inter and intrasession reliability of CKCUES Test for samples of sedentary male and female with (SIS), for samples of sedentary healthy male and female, and for male and female samples of healthy upper extremity sport specific recreational athletes. Other purpose was to compare scores within sedentary and within recreational athletes samples of same gender.


METHODS
A sample of 108 subjects with and without SIS was recruited. Subjects were tested twice, seven days apart. Each subject performed four test repetitions, with 45 seconds of rest between them. The last three repetitions were averaged and used to statistical analysis. Intraclass Correlation Coefficient ICC2,1 was used to assess intrasession reliability of number of touches score and ICC2,3 was used to assess intersession reliability of number of touches, normalized score, and power score. Test scores within groups of same gender also were compared. Measurement error was determined by calculating the Standard Error of the Measurement (SEM) and Minimum detectable change (MDC) for all scores.


RESULTS
The CKCUES Test showed excellent intersession reliability for scores in all samples. Results also showed excellent intrasession reliability of number of touches for all samples. Scores were greater in active compared to sedentary, with exception of power score. All scores were greater in active compared to sedentary and SIS males and females. SEM ranged from 1.45 to 2.76 touches (based on a 95% CI) and MDC ranged from 2.05 to 3.91(based on a 95% CI) in subjects with and without SIS. At least three touches are needed to be considered a real improvement on CKCUES Test scores.


CONCLUSION
Results suggest CKCUES Test is a reliable tool to evaluate upper extremity functional performance for sedentary, for upper extremity sport specific recreational, and for sedentary males and females with SIS.
The Influence of Coral Reef Benthic Condition on Associated Fish Assemblages

Accumulative disturbances can erode a coral reef's resilience, often leading to replacement of scleractinian corals by macroalgae or other non-coral organisms. These degraded reef systems have been mostly described based on changes in the composition of the reef benthos, and there is little understanding of how such changes are influenced by, and in turn influence, other components of the reef ecosystem. This study investigated the spatial variation in benthic communities on fringing reefs around the inner Seychelles islands. Specifically, relationships between benthic composition and the underlying substrata, as well as the associated fish assemblages were assessed. High variability in benthic composition was found among reefs, with a gradient from high coral cover (up to 58%) and high structural complexity to high macroalgae cover (up to 95%) and low structural complexity at the extremes. This gradient was associated with declining species richness of fishes, reduced diversity of fish functional groups, and lower abundance of corallivorous fishes. There were no reciprocal increases in herbivorous fish abundances, and relationships with other fish functional groups and total fish abundance were weak. Reefs grouping at the extremes of complex coral habitats or low-complexity macroalgal habitats displayed markedly different fish communities, with only two species of benthic invertebrate feeding fishes in greater abundance in the macroalgal habitat. These results have negative implications for the continuation of many coral reef ecosystem processes and services if more reefs shift to extreme degraded conditions dominated by macroalgae.
Structural optimization using sensitivity analysis and a level-set method q

In the context of structural optimization we propose a new numerical method based on a combination of the classical shape derivative and of the level-set method for front propagation. We implement this method in two and three space dimensions for a model of linear or nonlinear elasticity. We consider various objective functions with weight and perimeter constraints. The shape derivative is computed by an adjoint method. The cost of our numerical algorithm is moderate since the shape is captured on a fixed Eulerian mesh. Although this method is not specifically designed for topology optimization, it can easily handle topology changes. However, the resulting optimal shape is strongly dependent on the initial guess. 2003 Elsevier B.V. All rights reserved.
Finding the WRITE Stuff: Automatic Identification of Discourse Structure in Student Essays

automated feedback that helps them revise their work and ultimately improve their writing skills. These applications also address educational researchers’ interest in individualized instruction. Specifically, feedback that refers explicitly to students’own writing is more effective than general feedback.3 Our discourse analysis software, which is embedded in Criterion (www.etstechnologies.com), an online essay evaluation application, uses machine learning to identify discourse elements in student essays. The system makes decisions that exemplify how teachers perform this task. For instance, when grading student essays, teachers comment on the discourse structure. Teachers might explicitly state that the essay lacks a thesis statement or that an essay’s single main idea has insufficient support. Training the systems to model this behavior requires human judges to annotate a data sample of student essays. The annotation schema reflects the highly structured discourse of genres such as persuasive writing. Our discourse analysis system uses a voting algorithm that takes into account the discourse labeling decisions of three independent systems. The three systems employ natural language processing methods to extract essay-based features that help predict the discourse labels. They also use machine learning to classify the sentences in an essay as particular discourse elements. Our tool automatically labels discourse elements in student essays written on any topic and across writing genres.
Efficacy and acceptability of reduced intensity constraint-induced movement therapy for children aged 9-11 years with hemiplegic cerebral palsy: a pilot study.

OBJECTIVE
Assess efficacy and acceptability of reduced intensity constraint-induced movement therapy (CIMT) in children with cerebral palsy (CP).


METHODS
Single-subject research design and semi-structured interviews. Children (9-11y) with hemiplegia underwent five baseline assessments followed by two weeks CIMT. Six further assessments were performed during treatment and follow-up phases. The primary outcome was the Melbourne Assessment of Unilateral Upper Limb Function (MUUL). Quantitative data were analysed using standard single-subject methods and qualitative data by thematic analysis.


RESULTS
Four of the seven participants demonstrated statistically significant improvements in MUUL (3-11%, p < .05). Two participants achieved significant improvements in active range of motion but strength and tone remained largely unchanged. Qualitative interviews highlighted limitations of the restraint, importance of family involvement, and coordination of treatment with education.


CONCLUSIONS
Reduced intensity CIMT may be effective for some children in this population; however it is not suitable for all children with hemiplegia.
Infant growth patterns in the slums of Dhaka in relation to birth weight, intrauterine growth retardation, and prematurity.

BACKGROUND
Relations between size and maturity at birth and infant growth have been studied inadequately in Bangladesh, where the incidence of low birth weight is high and most infants are breast-fed.


OBJECTIVE
This study was conducted to describe infant growth patterns and their relations to birth weight, intrauterine growth retardation, and prematurity.


DESIGN
A total of 1654 infants born in selected low-socioeconomic areas of Dhaka, Bangladesh, were enrolled at birth. Weight and length were measured at birth and at 1, 3, 6, 9, and 12 mo of age.


RESULTS
The infants' mean birth weight was 2516 g, with 46.4% weighing <2500 g; 70% were small for gestational age (SGA) and 17% were premature. Among the SGA infants, 63% had adequate ponderal indexes. The mean weight of the study infants closely tracked the -2 SD curve of the World Health Organization pooled breast-fed sample. Weight differences by birth weight, SGA, or preterm categories were retained throughout infancy. Mean z scores based on the pooled breast-fed sample were -2.38, -1. 72, and -2.34 at birth, 3 mo, and 12 mo. Correlation analysis showed greater plasticity of growth in the first 3 mo of life than later in the first year.


CONCLUSIONS
Infant growth rates were similar to those observed among breast-fed infants in developed countries. Most study infants experienced chronic intrauterine undernourishment. Catch-up growth was limited and weight at 12 mo was largely a function of weight at birth. Improvement of birth weight is likely to lead to significant gains in infant nutritional status in this population, although interventions in the first 3 mo are also likely to be beneficial.
A Hybrid Algorithm Based on ACO and PSO for Capacitated Vehicle Routing Problems

The vehicle routing problem VRP is a well-known combinatorial optimization problem. It has been studied for several decades because finding effective vehicle routes is an important issue of logistic management. This paper proposes a new hybrid algorithm based on two main swarm intelligence SI approaches, ant colony optimization ACO and particle swarm optimization PSO , for solving capacitated vehicle routing problems CVRPs . In the proposed algorithm, each artificial ant, like a particle in PSO, is allowed to memorize the best solution ever found. After solution construction, only elite ants can update pheromone according to their own best-so-far solutions. Moreover, a pheromone disturbance method is embedded into the ACO framework to overcome the problem of pheromone stagnation. Two sets of benchmark problems were selected to test the performance of the proposed algorithm. The computational results show that the proposed algorithm performs well in comparison with existing swarm intelligence approaches.
Pulse pair beamforming and the effects of reflectivity field variations on imaging radars: PPB AND REFLECTIVITY EFFECTS ON IMAGING

[1] Coherent radar imaging (CRI), which is fundamentally a beamforming process, has been used to create images of microscale, reflectivity structures within the resolution volume of atmospheric Doppler radars. This powerful technique has the potential to unlock many new discoveries in atmospheric studies. The Turbulent Eddy Profiler (TEP) is a unique 915 MHz boundary layer radar consisting of a maximum of 91 independent receivers. The TEP configuration allows sophisticated CRI algorithms to be implemented providing significant improvement in angular resolution. The present work includes a thorough simulation study of some of the capabilities of the TEP system. The pulse pair processor, used for radial velocity and spectral width estimation with meteorological radars, is combined with beamforming technique, in an efficient manner, to the imaging radar case. By numerical simulation the new technique is shown to provide robust and computationally efficient estimates of the spectral moments. For this study, a recently developed atmospheric radar simulation method is employed that uses the ten thousand scattering points necessary for the high resolution imaging simulation. Previous methods were limited in the number of scatterers due to complexity issues. Radial velocity images from the beamforming radar are used to estimate the three-dimensional wind field map within the resolution volume. It is shown that a large root mean square (RMS) error in imputed three-dimensional wind fields can occur using standard Fourier imaging. This RMS error does not improve even as SNR is increased. The cause of the error is reflectivity variations within the resolution volume. The finite beamwidth of the beamformer skews the radial velocity estimate, and this results in poor wind field estimates. Adaptive Capon beamforming consistently outperforms the Fourier method in the quantitative study and has been demonstrated to enhance the performance compared to the Fourier method.
Impaired High‐Density Lipoprotein Anti‐Oxidative Function Is Associated With Outcome in Patients With Chronic Heart Failure

BACKGROUND
Oxidative stress is mechanistically linked to the pathogenesis of chronic heart failure (CHF). Antioxidative functions of high-density lipoprotein (HDL) particles have been found impaired in patients with ischemic cardiomyopathy; however, the impact of antioxidative HDL capacities on clinical outcome in CHF patients is unknown. We therefore investigated the predictive value of antioxidative HDL function on mortality in a representative cohort of patients with CHF.


METHODS AND RESULTS
We prospectively enrolled 320 consecutive patients admitted to our outpatient department for heart failure and determined antioxidative HDL function using the HDL oxidative index (HOI). During a median follow-up time of 2.8 (IQR: 1.8-4.9) years, 88 (27.5%) patients reached the combined cardiovascular endpoint defined as the combination of death due to cardiovascular events and heart transplantation. An HOI ≥1 was significantly associated with survival free of cardiovascular events in Cox regression analysis with a hazard ratio (HR) of 2.28 (95% CI 1.48-3.51, P<0.001). This association remained significant after comprehensive multivariable adjustment for potential confounders with an adjusted HR of 1.83 (95% CI 1.1-2.92, P=0.012). Determination of HOI significantly enhanced risk prediction beyond that achievable with N-terminal pro-B-type natriuretic peptide indicated by improvements in net reclassification index (32.4%, P=0.009) and integrated discrimination improvement (1.4%, P=0.04).


CONCLUSIONS
Impaired antioxidative HDL function represents a strong and independent predictor of mortality in patients with CHF. Implementation of HOI leads to a substantial improvement of risk prediction in patients with CHF.
Beta-cell dysfunction in subjects with impaired glucose tolerance and early type 2 diabetes: comparison of surrogate markers with first-phase insulin secretion from an intravenous glucose tolerance test.

OBJECTIVE
Methods to assess beta-cell function in clinical studies are limited. The aim of the current study was to compare a direct measure of insulin secretion with fasting surrogate markers in relation to glucose tolerance status.


RESEARCH DESIGN AND METHODS
In 1,380 individuals from the Insulin Resistance Atherosclerosis Study, beta-cell function was assessed using a frequently sampled intravenous glucose tolerance test (first-phase insulin secretion; acute insulin response [AIR]), homeostasis model assessment of beta-cell function (HOMA-B), proinsulin levels, and the proinsulin-to-insulin ratio. Beta-cell function was cross-sectionally analyzed by glucose tolerance categories (normal glucose tolerance [NGT], n = 712; impaired glucose tolerance [IGT], n = 353; newly diagnosed diabetes by 2-h glucose from an oral glucose tolerance test [OGTT] [DM2h], n = 80; newly diagnosed diabetes by fasting glucose [DMf], n = 135; or newly diagnosed diabetes by fasting and 2-h glucose and established diabetes on diet/exercise only [DM], n = 100).


RESULTS
In Spearman correlation analyses, proinsulin and the proinsulin-to-insulin ratio were only modestly inversely related to AIR (r values from -0.02 to -0.27), and AIR was strongly related to HOMA-B (r values 0.56 and 0.58). HOMA-B markedly underestimated the magnitude of the beta-cell defect across declining glucose tolerance, especially for IGT and new DM by OGTT compared with AIR. Analyses adjusting for insulin sensitivity showed that beta-cell function was compromised in IGT, DM2h, DMf, and DM, relative to NGT, by 13, 12, 59, and 62% (HOMA-B) and by as much as 40, 60, 80, and 75%, using AIR.


CONCLUSIONS
Subjects with IGT and early-stage, asymptomatic type 2 diabetic patients have more pronounced beta-cell defects than previously estimated from epidemiological studies using homeostasis model assessment.
Reconstructing/Deconstructing the Earliest Eukaryotes How Comparative Genomics Can Help

We could reconstruct the evolution of eukaryote-specific molecular and cellular machinery if some living eukaryotes retained primitive cellular structures and we knew which eukaryotes these were. It's not clear that either is the case, but the expanding protist genomic database could help us in several ways.