LLukas22/scidocs huggingface dataset:
Genome‐wide dissection of AP2/ERF and HSP90 gene families in five legumes and expression profiles in chickpea and pigeonpea

APETALA2/ethylene response factor (AP2/ERF) and heat-shock protein 90 (HSP90) are two significant classes of transcription factor and molecular chaperone proteins which are known to be implicated under abiotic and biotic stresses. Comprehensive survey identified a total of 147 AP2/ERF genes in chickpea, 176 in pigeonpea, 131 in Medicago, 179 in common bean and 140 in Lotus, whereas the number of HSP90 genes ranged from 5 to 7 in five legumes. Sequence alignment and phylogenetic analyses distinguished AP2, ERF, DREB, RAV and soloist proteins, while HSP90 proteins segregated on the basis of their cellular localization. Deeper insights into the gene structure allowed ERF proteins to be classified into AP2s based on DNA-binding domains, intron arrangements and phylogenetic grouping. RNA-seq and quantitative real-time PCR (qRT-PCR) analyses in heat-stressed chickpea as well as Fusarium wilt (FW)- and sterility mosaic disease (SMD)-stressed pigeonpea provided insights into the modus operandi of AP2/ERF and HSP90 genes. This study identified potential candidate genes in response to heat stress in chickpea while for FW and SMD stresses in pigeonpea. For instance, two DREB genes (Ca_02170 and Ca_16631) and three HSP90 genes (Ca_23016, Ca_09743 and Ca_25602) in chickpea can be targeted as potential candidate genes. Similarly, in pigeonpea, a HSP90 gene, C.cajan_27949, was highly responsive to SMD in the resistant genotype ICPL 20096, can be recommended for further functional validation. Also, two DREB genes, C.cajan_41905 and C.cajan_41951, were identified as leads for further investigation in response to FW stress in pigeonpea.
A fuzzy video content representation for video summarization and content-based retrieval

In this paper, a fuzzy representation of visual content is proposed, which is useful for the new emerging multimedia applications, such as content-based image indexing and retrieval, video browsing and summarization. In particular, a multidimensional fuzzy histogram is constructed for each video frame based on a collection of appropriate features, extracted using video sequence analysis techniques. This approach is then applied both for video summarization, in the context of a content-based sampling algorithm, and for content-based indexing and retrieval. In the "rst case, video summarization is accomplished by discarding shots or frames of similar visual content so that only a small but meaningful amount of information is retained (key-frames). In the second case, a content-based retrieval scheme is investigated, so that the most similar images to a query are extracted. Experimental results and comparison with other known methods are presented to indicate the good performance of the proposed scheme on real-life video recordings. ( 2000 Elsevier Science B.V. All rights reserved.
Neonatal ECMO Study of Temperature (NEST) - a randomised controlled trial

BACKGROUND
Existing evidence indicates that once mature neonates with severe cardio-respiratory failure become eligible for Extra Corporeal Membrane Oxygenation (ECMO) their chances of intact survival are doubled if they actually receive ECMO. However, significant numbers survive with disability. NEST is a multi-centre randomised controlled trial designed to test whether, in neonates requiring ECMO, cooling to 34 degrees C for the first 48 to 72 hours of their ECMO course leads to improved later health status. Infants allocated to the control group will receive ECMO at 37 degrees C throughout their course, which is currently standard practice around the world. Health status of both groups will be assessed formally at 2 years corrected age.


METHODS/DESIGN
All infants recruited to the study will be cared for in one of the four United Kingdom (UK) ECMO centres. Babies who are thought to be eligible will be assessed by the treating clinician who will confirm eligibility, ensure that consent has been obtained and then randomise the baby using a web based system, based at the National Perinatal Epidemiology Unit (NPEU) Clinical Trials Unit. Trial registration.Babies allocated ECMO without cooling will receive ECMO at 37 degrees C +/- 0.2 degrees C. Babies allocated ECMO with cooling will be managed at 34 degrees C +/- 0.2 degrees C for up to 72 hours from the start of their ECMO run. The minimum duration of cooling will be 48 hours. Rewarming (to 37 degrees C) will occur at a rate of no more than 0.5 degrees C per hour. All other aspects of ECMO management will be identical.


PRIMARY OUTCOME
Cognitive score from the Bayley Scales of Infant and Toddler Development, 3rd edition (Bayley-III) at age of 2 years (24 - 27 months).


DISCUSSION
For the primary analysis, children will be analysed in the groups to which they are assigned, comparing the outcome of all babies allocated to "ECMO with cooling" with all those allocated to "ECMO" alone, regardless of deviation from the protocol or treatment received. For the primary outcome the analysis will compare the mean scores for each group of surviving babies. The rationale for this choice of primary analysis is to give a fair representation of the average ability of assessable children, accepting the limitation that excluding deaths might impose.The consistency of the effect of cooling on the group of babies recruited to the trial will be explored to see whether cooling is of particular help, or not, to specific subgroups of infants, using the statistical test of interaction. Therefore pre-specified subgroup analyses include: (i) whether the ECMO is veno-arterial or veno-venous; (ii) whether the child's oxygenation index at the time of recruitment is <60 or > or = 60; (iii) initial aEEG pattern shown on the cerebral function monitor, and (iv) primary diagnostic group.


TRIAL REGISTRATION
Current Controlled Trials ISRCTN72635512.
Poisoning of hydrogen dissociation at Pd(100) by adsorbed sulfur studied by ab initio quantum dynamics and ab initio molecular dynamics

Abstract We report calculations of the dissociative adsorption of H 2 at Pd (100) covered with 1/4 monolayer of sulfur using quantum dynamics as well as molecular dynamics and taking all six degrees of freedom of the two H atoms fully into account. The ab-initio potential-energy surface (PES) is found to be very strongly corrugated. In particular, we discuss the influence of tunneling, zero-point vibrations due to the localization of the wave function of the nuclei when narrow valleys of the PES are passed, steering of the approaching H 2 molecules towards low-energy barrier configurations, and the important role of subsurface absorbates for the hydrogen dissociation. It is shown that “established” concepts derived from low-dimensional dynamical studies are not necessarily valid in a high-dimensional treatment.
Rapid oral transmucosal absorption of sumatriptan, and pharmacodynamics in acute migraine.

OBJECTIVES
(1) To determine whether sumatriptan can be absorbed across the oral mucosa, and, if so; then (2) to describe its pharmacokinetics; and (3) to investigate whether there are pharmacodynamic correlates of such pharmacokinetics in patients experiencing migraine attacks.


METHODS
Two clinical trials. The first, in normal volunteers, compared the pharmacokinetic performance of a lingual spray (LS) formulation of sumatriptan (2 dose sizes, one of which in both the fed and fasted state) with an orthodox 50-mg sumatriptan tablet. The second clinical trial, in a patient population enriched by documenting suboptimal response to an initial 50-mg sumatriptan tablet, was a multiple-attack, crossover, fixed dose-order, open-label comparison of sumatriptan administered by LS (up to 3 different dose sizes) and a 100-mg sumatriptan tablet.


RESULTS
The LS formulations resulted in double-peaked time-plasma concentration curves that are consistent with absorption of sumatriptan across the oral mucosa. The first T(max) was usually about 10-15 minutes. In the enriched patient population, this corresponded with evidence of earlier efficacy for the LS in comparison with a 50-mg tablet; the lower dose size for the former was consistent with oral mucosal drug absorption, and evasion of first-pass metabolism.


CONCLUSIONS
The initial pharmacokinetics of LS approximate to those of a subcutaneous injection, albeit some fraction of these doses is also swallowed. These pharmacokinetics correspond with earlier effectiveness of LS in comparison with a 50-mg sumatriptan tablet, and at lower dose, in an enriched, relevant patient population. These initial studies support further development of this innovative formulation of sumatriptan and this new route of administration.
The Interplay of Beauty, Goodness, and Usability in Interactive Products

Two studies considered the interplay between user-perceived usability (i.e., pragmatic attributes), hedonic attributes (e.g., stimulation, identification), goodness (i.e., satisfaction), and beauty of 4 different MP3-player skins. As long as beauty and goodness stress the subjective valuation of a product, both were related to each other. However, the nature of goodness and beauty was found to differ. Goodness depended on both perceived usability and hedonic attributes. Especially after using the skins, perceived usability became a strong determinant of goodness. In contrast, beauty largely depended on identification; a hedonic attribute group, which captures the product’s ability to communicate important personal values to relevant others. Perceived usability as well as goodness was affected by experience (i.e., actual usability, usability problems), whereas hedonic attributes and beauty remained stable over time. All in all, the nature of beauty is rather self-oriented than goal-oriented, whereas goodness relates to both. HUMAN-COMPUTER INTERACTION, 2004, Volume 19, pp. 319–349 Copyright © 2004, Lawrence Erlbaum Associates, Inc. Marc Hassenzahl is a psychologist with an interest in applying research on social cognition, judgment, and choice to human–computer interaction; he is a researcher and lecturer in the Institute of Psychology, Social Psychology and Decision-Making, of the Darmstadt University of Technology in Germany.
Business intelligence success: The roles of BI capabilities and decision environments

This study examines the role of the decision environment in how well business intelligence (BI) capabilities are leveraged to achieve BI success. We examine the decision environment in terms of the types of decisions made and the information processing needs of the organization. Our findings suggest that technological capabilities such as data quality, user access and the integration of BI with other systems are necessary for BI success, regardless of the decision environment. However, the decision environment does influence the relationship between BI success and capabilities, such as the extent to which BI supports flexibility and risk in decision making. 2013 Elsevier B.V. All rights reserved. * Corresponding author. Tel.: +32 16248854. E-mail addresses: oyku.isik@vlerick.com (Ö. Işık), mary.jones@unt.edu (M.C. Jones), anna.sidorova@unt.edu (A. Sidorova).
Parent Stress and Coping: Waiting for a Child to Receive a Kidney Transplant

The current study examined the degree of parent stress and depression among mothers and fathers of children with end-stage renal disease (ESRD) listed for a kidney transplant, to determine whether demographic factors, stress, and coping would predict parent depression. Eighty-six mothers and 58 fathers of children with ESRD preparing for a kidney transplant completed standardized measures of parent stress related to the child’s chronic illness (PIP), coping style (Brief Cope), and depression (BDI-II). Information about the disease was obtained from the medical record. Maternal depression was predicted by having a lower family income, higher degree of parent stress associated with the child’s illness, and the use of avoidant coping strategies. Paternal depression was only predicted by higher parent stress. Illness related variables did not contribute significantly to the understanding of parent outcomes. Pre-transplant evaluations should screen for elevated levels of stress and depression, and develop interventions to help parents cope with their child’s renal disease.
IR Stereo Kinect: Improving Depth Images by Combining Structured Light with IR Stereo

RGB-D sensors such as the Microsoft Kinect or the Asus Xtion are inexpensive 3D sensors. A depth image is computed by calculating the distortion of a known infrared light (IR) pattern which is projected into the scene. While these sensors are great devices they have some limitations. The distance they can measure is limited and they suffer from reflection problems on transparent, shiny, or very matte and absorbing objects. If more than one RGB-D camera is used the IR patterns interfere with each other. This results in a massive loss of depth information. In this paper, we present a simple and powerful method to overcome these problems. We propose a stereo RGBD camera system which uses the pros of RGB-D cameras and combine them with the pros of stereo camera systems. The idea is to utilize the IR images of each two sensors as a stereo pair to generate a depth map. The IR patterns emitted by IR projectors are exploited here to enhance the dense stereo matching even if the observed objects or surfaces are texture-less or transparent. The resulting disparity map is then fused with the depth map offered by the RGB-D sensor to fill the regions and the holes that appear because of interference, or due to transparent or reflective objects. Our results show that the density of depth information is increased especially for transparent, shiny or matte objects.
FRAMES – A Risk Assessment Framework for e-Services

e-Government projects are expected to increase efficiency and quality of government services, whilst decreasing the costs. Unfortunately though, together with its perceived positive potential, e-Government also entails risks. It is expected that the employment of proper risk assessment methods in the management of such projects will reduce the threats imposed by the various risks that surround these projects. This paper discusses about risk in e-Government and provides a high-level eGovernment risk factor classification. Furthermore, this article proposes a novel risk assessment framework for e-Services in the public administration.
Detection of ECG characteristic points using wavelet transforms

An algorithm based on wavelet transforms (WT's) has been developed for detecting ECG characteristic points. With the multiscale feature of WT's, the QRS complex can be distinguished from high P or T waves, noise, baseline drift, and artifacts. The relation between the characteristic points of ECG signal and those of modulus maximum pairs of its WT's is illustrated. By using this method, the detection rate of QRS complexes is above 99.8% for the MIT/BIH database and the P and T waves can also be detected, even with serious base line drift and noise.<<ETX>>
An Augmented Reality Delivery Simulator for Medical Training

This paper presents the extension of a birth simulator for medical training with an augmented reality system. The system presents an add-on of the user interface for our previous work on a mixed reality delivery simulator system [1]. This simulation system comprised direct haptic and auditory feedback, and provided important physiological data including values of blood pressure, heart rates, pain and oxygen supply, necessary for training physicians. Major drawback of the system was the indirect viewing of both the virtual models and the final delivery process. The current paper extends the existing system by bringing in the in-situ visualization. This plays an important role in increasing the efficiency of the training, since the physician now concentrates on the vaginal delivery rather than the remote computer screen. In addition, forceps are modeled and an external optical tracking system is integrated in order to provide visual feedback while training with the simulator for complicated procedures such as forceps delivery.
Industrial robot motion control with real-time Java and EtherCAT

Safe object-oriented programming languages like Java provide a much more programmer-friendly environment than the low-level languages in which real-time and embedded software have traditionally been implemented. Therefore, with the recent popularity of real-time Java, it is interesting to examine its feasibility for robot motion control. We have implemented a motion control system, and an application, for an ABB IRB 340 industrial robot entirely in real-time Java, using standard computer hardware, off-the-shelf EtherCAT servo drives, and the Sun Java Real-Time System 2.0 on Solaris 10. This shows the feasibility of realtime Java for practical robot applications. It also shows one advantage of the EtherCAT field bus technology, that no special master hardware is required. To our knowledge, this is the first robot control system implemented entirely in Java and executed on a certified virtual machine.
Safety of withholding anticoagulation in pregnant women with suspected deep vein thrombosis following negative serial compression ultrasound and iliac vein imaging.

BACKGROUND
Compression ultrasonography performed serially over a 7-day period is recommended for the diagnosis of deep vein thrombosis in symptomatic pregnant women, but whether this approach is safe is unknown. We evaluated the safety of withholding anticoagulation from pregnant women with suspected deep vein thrombosis following negative serial compression ultrasonography and iliac vein imaging.


METHODS
Consecutive pregnant women who presented with suspected deep vein thrombosis underwent compression ultrasonography and Doppler imaging of the iliac vein of the symptomatic leg(s). Women whose initial test results were negative underwent serial testing on 2 occasions over the next 7 days. Women not diagnosed with deep vein thrombosis were followed for a minimum of 3 months for the development of symptomatic deep vein thrombosis or pulmonary embolism.


RESULTS
In total, 221 pregnant women presented with suspected deep vein thrombosis. Deep vein thrombosis was diagnosed in 16 (7.2%) women by initial compression ultrasonography and Doppler studies; none were identified as having deep vein thrombosis on serial testing. One patient with normal serial testing had a pulmonary embolism diagnosed 7 weeks later. The overall prevalence of deep vein thrombosis was 7.7% (17/221); of these, 65% (11/17) of cases were isolated to the iliofemoral veins and 12% (2/17) were isolated iliac deep vein thromboses. The incidence of venous thromboembolism during follow-up was 0.49% (95% confidence interval [CI] 0.09%-2.71%). The sensitivity of serial compression ultrasonography with Doppler imaging was 94.1% (95% CI 69.2%-99.7%), the negative predictive value was 99.5% (95% CI 96.9%-100%), and the negative likelihood ratio was 0.068 (95% CI 0.01-0.39).


INTERPRETATION
Serial compression ultrasonography with Doppler imaging of the iliac vein performed over a 7-day period excludes deep-vein thrombosis in symptomatic pregnant women.
Women battering in primary care practice.

BACKGROUND
The organization of health care system to emphasize managed care has placed the primary care provider in an ideal position to assess the impact of intimate partner violence (IPV) on the health of women. Primary care practice provides a setting in which women can develop an ongoing relationship with their health care provider in which they feel safe to discuss IPV and possible options to improve their lives. Women's health and safety could be dramatically improved if primary care providers were prepared to assess, intervene and appropriately refer women who are in violent relationships.


OBJECTIVES
The purpose of this article is to describe the prevalence of intimate partner violence in primary care populations and review the known physical, mental health and pregnancy consequences of abuse as well as discuss the implications of intimate partner violence on primary care practice.
Morphology of male genitalia in lice and their relatives and phylogenetic implications

Lice (Insecta: Phthiraptera) have long been considered to compose a monophyletic group of insects on the basis of external morphological characteristics. However, a recent phylogenetic analysis of 18S rDNA sequences suggested that ‘Phthiraptera’ have arisen twice within the order Psocoptera (booklice and barklice). The external features of lice are highly specialized to a parasitic lifestyle, and convergence may be frequent for such characters. To provide a further test between traditional and recent molecular-based phylogenetic hypotheses, a phylogenetic analysis of lice and relatives based on morphological characters that are independent from the selective pressures of a parasitic lifestyle is needed. Here, we examined the morphology of the male phallic organ in lice and relatives (‘Psocoptera’: suborders Troctomorpha and Psocomorpha) and detected some novel modifications that were stable within each group and useful for higher level phylogenetic reconstruction. Phylogenetic analysis based on these characters provided a concordant result with the 18S-based phylogeny. In particular, the apomorphic presence of articulations between the basal plate, mesomere and ventral plate (1⁄4 sclerite on the permanently everted endophallus) is observed consistently throughout the psocid families Pachytroctidae and Liposcelididae and the louse suborder Amblycera, providing support for a clade composed of these three groups, although possible homoplasy was detected in some Ischnocera. This is the first study to provide morphological support for the polyphyly of lice.
Use of ranolazine in patients with incomplete revascularization after percutaneous coronary intervention: design and rationale of the Ranolazine for Incomplete Vessel Revascularization Post-Percutaneous Coronary Intervention (RIVER-PCI) trial.

BACKGROUND
Incomplete revascularization (ICR) after percutaneous coronary intervention (PCI) is common and is associated with increased rates of rehospitalization, revascularization, and mortality. Adjunctive pharmacotherapy with ranolazine, an inhibitor of the late sodium current with anti-ischemic properties, may be effective in reducing recurrent events after PCI in patients with ICR.


TRIAL DESIGN
RIVER-PCI is a phase 3, randomized, double-blind, placebo-controlled, international event-driven clinical trial evaluating the efficacy of ranolazine in patients with a history of chronic angina and ICR after PCI. Approximately 2,600 participants with ICR post-PCI will be randomized in a 1:1 ratio to ranolazine or matched placebo within 14 days of an index PCI. The primary end point of the trial is time to the first occurrence of ischemia-driven revascularization or ischemia-driven hospitalization without revascularization. Participants will be followed up for a minimum of 1 year and until at least 720 confirmed primary end point events have occurred. Secondary end points include sudden cardiac death, cardiovascular death, myocardial infarction, and measures of quality of life and cost-effectiveness. The evaluation of long-term safety will include all-cause mortality, stroke, transient ischemic attack, and hospitalization for heart failure. Enrollment commenced in November 2011 and was completed in summer 2013.


CONCLUSIONS
RIVER-PCI is a novel, large-scale, international, randomized, double-blind, placebo-controlled clinical trial evaluating the role of ranolazine in the long-term medical management of patients with ICR post-PCI.