LLukas22/scidocs huggingface dataset:
The role of imaging in the diagnosis and management of thoracolumbar burst fractures: current concepts and a review of the literature

 The burst fracture of the spine was first described by Holdsworth in 1963 and redefined by Denis in 1983 as being a fracture of the anterior and middle columns of the spine with or without an associated posterior column fracture. This injury has received much attention in the literature as regards its radiological diagnosis and also its clinical managment. The purpose of this article is to review the way that imaging has been used both to diagnose the injury and to guide management. Current concepts of the stability of this fracture are presented and our experience in the use of magnetic resonance imaging in deciding treatment options is discussed.
Marine pharmacology in 2003-4: marine compounds with anthelmintic antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiplatelet, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems, and other miscellaneous mech

The current marine pharmacology review that covers the peer-reviewed literature during 2003 and 2004 is a sequel to the authors' 1998-2002 reviews, and highlights the preclinical pharmacology of 166 marine chemicals derived from a diverse group of marine animals, algae, fungi and bacteria. Anthelmintic, antibacterial, anticoagulant, antifungal, antimalarial, antiplatelet, antiprotozoal, antituberculosis or antiviral activities were reported for 67 marine chemicals. Additionally 45 marine compounds were shown to have significant effects on the cardiovascular, immune and nervous system as well as possessing anti-inflammatory effects. Finally, 54 marine compounds were reported to act on a variety of molecular targets and thus may potentially contribute to several pharmacological classes. Thus, during 2003-2004, research on the pharmacology of marine natural products which involved investigators from Argentina, Australia, Brazil, Belgium, Canada, China, France, Germany, India, Indonesia, Israel, Italy, Japan, Mexico, Morocco, the Netherlands, New Zealand, Norway, Panama, the Philippines, Portugal, Russia, Slovenia, South Korea, Spain, Thailand, Turkey, United Kingdom, and the United States, contributed numerous chemical leads for the continued global search for novel therapeutic agents with broad spectrum activity.
Independence and interdependencies among global ocean color properties: Reassessing the bio‐optical assumption

[1] The bio-optical assumption states that ocean optical properties should covary with the chlorophyll concentration. However, chlorophyll is not the only constituent capable of absorbing and scattering light as phytoplankton, detrital particles, colored dissolved organic material (CDOM), and suspended solids all contribute independently to ocean color. Here we employ a semi-analytical ocean color algorithm, the Garver-SiegelMaritorena model (GSM01), to decompose ocean color imagery from the Sea-viewing Wide Field of view Sensor (SeaWiFS) into optically relevant components for phytoplankton absorption (related to the chlorophyll concentration, Chl), colored nonalgal absorption and particulate backscatter. Semi-analytical Chl retrievals are consistent with available open ocean observations but show important differences compared with the standard SeaWiFS algorithm (OC4v4). These differences may be accounted for by the absorption due to colored detrital materials (CDM; the sum of colored dissolved organic material and detrital particulates). Values of CDM are a large and variable fraction of the total non-water absorption at 440 nm varying from 30 to 40% in the subtropical gyres to more than 60% at high latitudes. Retrievals of particulate backscatter (BBP) vary comparatively little. In the tropical and subtropical oceans, changes in BBP are largely unrelated to Chl, while at higher latitudes, BBP increases mirror changes in Chl. For much of the ocean, alterations in the relationship between BBP and Chl are consistent with a physiological response by phytoplankton to changes in mixed layer light, nutrients, and temperature. Regional scale correspondences among the three ocean color properties illustrate both independent and interdependent variations which can be explained by assessing the regional scale forcing mechanisms driving changes in ocean color properties.
Mathematical structures of language

Want to get experience? Want to get any ideas to create new things in your life? Read mathematical structures of language now! By reading this book as soon as possible, you can renew the situation to get the inspirations. Yeah, this way will lead you to always think more and more. In this case, this book will be always right for you. When you can observe more about the book, you will know why you need this.
Chapter 5 Musical Virtuosity and Creativity

Virtuosos are human beings who exhibit exceptional performance in their field of activity. In particular, virtuosos are interesting for creativity studies because they are exceptional problem solvers. However, virtuosity is an under-studied field of human behaviour. Little is known about the processes involved to become a virtuoso, and in how they distinguish themselves from normal performers. Virtuosos exist in virtually all domains of human activities, and we focus in this chapter on the specific case of virtuosity in jazz improvisation. We first introduce some facts about virtuosos coming from physiology, and then focus on the case of jazz. Automatic generation of improvisation has long been a subject of study for computer science, and many techniques have been proposed to generate music improvisation in various genres. The jazz style in particular abounds with programs that create improvisations of a reasonable level. However, no approach so far exhibits virtuosolevel performance. We describe an architecture for the generation of virtuoso bebop phrases which integrates novel music generation mechanisms in a principled way. We argue that modelling such outstanding phenomena can contribute substantially to the understanding of creativity in humans and machines. 5.1 Virtuosos as Exceptional Humans 5.1.1 Virtuosity in Art There is no precise definition of virtuosity, but only a commonly accepted view that virtuosos are human beings that excel in their practice to the point of exhibiting exceptional performance. Virtuosity exists in virtually all forms of human activity. In painting, several artists use virtuosity as a means to attract the attention of their audience. Felice Varini paints on urban spaces in such a way that there is a unique viewpoint from which a spectator sees the painting as a perfect geometrical figure. The F. Pachet ( ) Sony CSL-Paris, 6, rue Amyot, 75005 Paris, France e-mail: pachet@csl.sony.fr J. McCormack, M. d’Inverno (eds.), Computers and Creativity, DOI 10.1007/978-3-642-31727-9_5, © Springer-Verlag Berlin Heidelberg 2012 115
Increased Skeletal Muscle Capillarization After Aerobic Exercise Training and Weight Loss Improves Insulin Sensitivity in Adults With IGT

OBJECTIVE
Transcapillary transport of insulin is one determinant of glucose uptake by skeletal muscle; thus, a reduction in capillary density (CD) may worsen insulin sensitivity. Skeletal muscle CD is lower in older adults with impaired glucose tolerance (IGT) compared with those with normal glucose tolerance and may be modifiable through aerobic exercise training and weight loss (AEX+WL). We tested the hypothesis that 6-month AEX+WL would increase CD to improve insulin sensitivity and glucose tolerance in older adults with IGT.


RESEARCH DESIGN AND METHODS
Sixteen sedentary, overweight-obese (BMI 27-35 kg/m2), older (63 ± 2 years) men and women with IGT underwent hyperinsulinemic-euglycemic clamps to measure insulin sensitivity, oral glucose tolerance tests, exercise and body composition testing, and vastus lateralis muscle biopsies to determine CD before and after 6-month AEX+WL.


RESULTS
Insulin sensitivity (M) and 120-min postprandial glucose (G120) correlated with CD at baseline (r = 0.58 and r = -0.60, respectively, P < 0.05). AEX+WL increased maximal oxygen consumption (VO2max) 18% (P = 0.02) and reduced weight and fat mass 8% (P < 0.02). CD increased 15% (264 ± 11 vs. 304 ± 14 capillaries/mm(2), P = 0.01), M increased 21% (42.4 ± 4.0 vs. 51.4 ± 4.3 µmol/kg FFM/min, P < 0.05), and G120 decreased 16% (9.35 ± 0.5 vs. 7.85 ± 0.5 mmol/L, P = 0.008) after AEX+WL. Regression analyses showed that the AEX+WL-induced increase in CD independently predicted the increase in M (r = 0.74, P < 0.01) as well as the decrease in G120 (r = -0.55, P < 0.05).


CONCLUSIONS
Six-month AEX+WL increases skeletal muscle CD in older adults with IGT. This represents one mechanism by which AEX+WL improves insulin sensitivity in older adults with IGT.
Mannersm : A Theory of Culture

Referring to mannerism, popular culture and appropriation, texts by 11 North American and European artists offer a political critique of existing cultural forms, with the aim of developing a theory of artistic practice, which would redefine the relationship of art to its audience. Biographical notes. Circa 250 bibl. ref.
Identifying the content area for the 51-item National Eye Institute Visual Function Questionnaire: results from focus groups with visually impaired persons.

OBJECTIVE
To identify the content area for a questionnaire designed to measure vision-targeted health-related quality of life and to determine whether problems with vision-related functioning are qualitatively similar across different common eye diseases.


DESIGN
Twenty-six condition-specific focus groups were conducted with 246 patients from 5 geographic regions to identify the content area for a questionnaire for use among persons with diabetic retinopathy, glaucoma, macular degeneration, cytomegalovirus retinitis, and cataract. A standard protocol was used to structure each focus group discussion. Sessions were audiotaped, transcribed, and coded in preparation for a content analysis.


SETTINGS
Five university-based ophthalmology practices and 1 nonprofit eye care foundation.


PARTICIPANTS
Eligible participants had to have 1 of the following eye conditions: age-related cataracts, age-related macular degeneration, diabetic retinopathy, primary open angle glaucoma, cytomegalovirus retinitis, or low vision from any cause. All eligible persons were older than 21 years, spoke English, and had sufficient cognitive function to provide informed consent.


RESULTS
Among the 246 participants, 2623 problems with vision-related functioning were mentioned. The mean number of problems per person ranged from 13.5 for those with diabetic retinopathy to 7.9 for persons with glaucoma. For the sample overall, reading problems were mentioned most frequently, followed by driving, general problems with seeing clearly, and mental health complaints caused by vision. Although the proportion of persons who reported each problem varied by condition, at least some persons with each eye disease reported each problem. The 3 most common descriptors associated with each problem were difficulty or ease of performance (13%), psychological distress associated with performance of the activity (11%), and complete inability to participate in a visual activity (11%).


CONCLUSION
An item-generation strategy for a new questionnaire using a standardized focus group method identified content areas and aspects of visual disability that are not included in currently available vision-specific instruments that assess the impact of common eye diseases on visual functioning in every-day life. Although participants mentioned problems that were unique to their disease, across conditions the problems mentioned were similar. These findings provide empirical evidence of content validity for a vision-targeted, health-related quality-of-life survey designed for use across conditions.
Phase II study of sequential methotrexate and 5-fluorouracil chemotherapy against peritoneally disseminated gastric cancer with malignant ascites: a report from the Gastrointestinal Oncology Study Group of the Japan Clinical Oncology Group, JCOG 9603 Trial.

BACKGROUND
The efficacy of systemic chemotherapy against peritoneal dissemination from advanced gastric cancer (AGC) remains unclear, because the peritoneal dissemination was not defined as a measurable lesion in conventional phase II studies. In this study, we evaluated the efficacy and toxicity of sequential MTX and 5FU therapy (MF) in chemotherapy-naive patients with AGC accompanied by malignant ascites in a phase II setting.


METHODS
The treatment schedule comprised weekly administration of MTX (100 mg/m2, i.v. bolus) followed by 5FU (600 mg/m2, i.v. bolus) with a 3 h interval. Leucovorin rescue (10 mg/m2 every 6 h, for a total of six times) was commenced 24 h after MTX administration.


RESULTS
Thirty-seven chemotherapy-naive patients with AGC presenting with malignant ascites were enrolled in this trial. The median age was 60 years (range, 25-74 years) and most patients (86%) had a performance status of 0-1. In total, 355 administrations of the sequential MTX/5FU therapy were performed. Major toxicity consisted of myelosuppression and gastrointestinal toxicity. Grade 4 neutropenia occurred in 10.8% of the patients. The overall objective response rate was 5.7% (two partial responses in 35 patients; 95% confidence interval: 0.7-19.2%). However, the response rate of ascites was 35.1% (complete disappearance in three patients and apparent decrease in 10 patients; 95% confidence interval: 20.2-52.5%).


CONCLUSIONS
Sequential MTX/5FU therapy is effective against AGC with malignant ascites with acceptable toxicity and warrants further investigations in a phase III setting.
Improving the management of family psychosocial problems at low-income children's well-child care visits: the WE CARE Project.

OBJECTIVE
Our goal was to evaluate the feasibility and impact of an intervention on the management of family psychosocial topics at well-child care visits at a medical home for low-income children.


PATIENTS AND METHODS
A randomized, controlled trial of a 10-item self-report psychosocial screening instrument was conducted at an urban hospital-based pediatric clinic. Pediatric residents and parents were randomly assigned to either the intervention or control group. During a 12-week period, parents of children aged 2 months to 10 years presenting for a well-child care visit were enrolled. The intervention components included provider training, administration of the family psychosocial screening tool to parents before the visit, and provider access to a resource book that contained community resources. Parent outcomes were obtained from postvisit and 1-month interviews, and from medical chart review. Provider outcomes were obtained from a self-administered questionnaire collected after the study.


RESULTS
Two hundred parents and 45 residents were enrolled. Compared with the control group, parents in the intervention group discussed a significantly greater number of family psychosocial topics (2.9 vs 1.8) with their resident provider and had fewer unmet desires for discussion (0.46 vs 1.41). More parents in the intervention group received at least 1 referral (51.0% vs 11.6%), most often for employment (21.9%), graduate equivalent degree programs (15.3%), and smoking-cessation classes (14.6%). After controlling for child age, Medicaid status, race, educational status, and food stamps, intervention parents at 1 month had greater odds of having contacted a community resource. The majority of residents in the intervention group reported that the survey instrument did not slow the visit; 54% reported that it added <2 minutes to the visit.


CONCLUSIONS
Brief family psychosocial screening is feasible in pediatric practice. Screening and provider training may lead to greater discussion of topics and contact of community family support resources by parents.
Facebook Spam and Spam Filter Using Artificial Neural Networks

Spam is any unwanted electronic message or material in any form posted too many people. As the world is growing as global world, social networking sites play an important role in making world global providing people from different parts of the world a platform to meet and express their views. Among different social networking sites Facebook become the leading one. With increase in usage different users start abusive use of Facebook by posting or creating ways to post spam. This paper highlights the potential spam types nowadays Facebook users’ faces. This paper also provide the reason how user become victim to spam attack. A methodology is proposed in the end discusses how to handle different types of spam. Keywords—Artificial neural networks, Facebook spam, social networking sites, spam filter.
New Attacks on all Double Block Length Hash Functions of Hash Rate 1, including the Parallel-DM

In this paper attacks on double block length hash functions using a block cipher are considered. We present attacks on all double block length hash functions of hash rate 1, that is, hash functions where in each round the block cipher is used twice, s.t. one encryption is needed per message block. In particular, our attacks break the Parallel-DM presented at Crypto'9333].
Psychological capital, a requisite for organisational performance in South Africa

Scholars argue that to address the social, economic and political challenges facing South Africa since 1994, organisational managers/leaders should adopt a positive approach, based on sound organisational behaviour. This study administered the Psychological Capital Questionnaire (PCQ) to determine whether human resources practitioners (N=131) as custodians of change and positive behaviour in organisations in South Africa embrace core elements of Positive Organisational Behaviour (POB). Exploratory factor analysis resulted in a three-factor model for the PCQ, renamed the Potential South African PsyCap (PSAPsyCap) instrument. All dimensions displayed acceptable reliabilities. Statistically significant differences exist in the POB of demographic groups, relating to age, marital status, home language, seniority and qualifications. This research reveals that South African HR practitioners and managers should fully embrace psychological capital to effectively create caring workplaces taking cognizance of the broader economic and social issues affecting employees and their performance.
Locally Decodable Codes

An r-query Locally Decodable Code (LDC) C encodes k-symbol messages x to n-symbol codewords C(x). For every i ∈ [k] the decoder has a family Di of r-subsets of the universe [n]. These families are carefully designed to ensure that for all messages x, for each i ∈ [k] and S ∈ Di the symbol x(i) can be recovered from accessing r coordinates of C(x) that belong to S. Furthermore families Di are required to satisfy the following two conditions:
Sigma*: symbolic learning of input-output specifications

We present Sigma*, a novel technique for learning symbolic models of software behavior. Sigma* addresses the challenge of synthesizing models of software by using symbolic conjectures and abstraction. By combining dynamic symbolic execution to discover symbolic input-output steps of the programs and counterexample guided abstraction refinement to over-approximate program behavior, Sigma* transforms arbitrary source representation of programs into faithful input-output models. We define a class of stream filters---programs that process streams of data items---for which Sigma* converges to a complete model if abstraction refinement eventually builds up a sufficiently strong abstraction. In other words, Sigma* is complete relative to abstraction. To represent inferred symbolic models, we use a variant of symbolic transducers that can be effectively composed and equivalence checked. Thus, Sigma* enables fully automatic analysis of behavioral properties such as commutativity, reversibility and idempotence, which is useful for web sanitizer verification and stream programs compiler optimizations, as we show experimentally. We also show how models inferred by Sigma* can boost performance of stream programs by parallelized code generation.
High rate of extra-haematological toxicity compromises dose-dense sequential adjuvant chemotherapy for breast cancer

Background:A dose-dense strategy has been considered to improve results of adjuvant chemotherapy for breast cancer. This randomised phase II trial investigated the feasibility of this approach with sequential anthracyclines and taxanes-based chemotherapy.Methods:Patients with high-risk node-positive breast cancer were treated with three cycles of fluorouracil 500 mg m−2, epirubicin 100 mg m−2, cyclophosphamide 500 mg m−2 (FEC 100) followed by three cycles of docetaxel 100 mg m−2 delivered at 2-weekly intervals supported by primary prophylaxis with filgrastim. All patients were randomised to either uninterrupted treatment (arm A) or to have a 2-week additional period of rest between the FEC and docetaxel (arm B). The primary endpoint was the rate of success of chemotherapy delivery. Using a two-stage Fleming design, 120 patients were required with one interim analysis.Results:In March 2005, enrolment was stopped into arm A after the observation of severe skin toxicities. Following the planned interim analysis, the study was closed because of the high rate of grade 3/4 skin toxicities in both arms (arm A: 32.4% and arm B: 18.9%).Conclusion:Sequential dose-dense FEC 100 followed by docetaxel 100 mg m−2 is not feasible. Feasibility still depends largely on several factors including the choice of drugs, dosage and sequence of administration.
Neuropsychological profiles of an elderly cohort undergoing elective surgery and the relationship between cognitive performance and delirium.

OBJECTIVES
To examine baseline (preoperative) neuropsychological test performance in a cohort of elderly individuals undergoing elective surgery and the association between specific neuropsychological domains and postoperative delirium.


DESIGN
Ongoing prospective cohort study.


SETTING
Successful Aging after Elective Surgery Study.


PARTICIPANTS
Elderly adults (N=300) scheduled for elective (noncardiac) surgery.


MEASUREMENTS
Neuropsychological testing, including standardized assessments of memory, divided and sustained attention, speed of mental processing, verbal fluency, working memory, language, and an overall measure of premorbid cognitive functioning, was performed 2 to 4 weeks before surgery. The relationship between the individual neuropsychological tests and delirium status was examined using linear regression, adjusting for age, sex, and education.


RESULTS
Study participants were generally highly educated (mean years of education 15.0±2.9), with minimal or no cognitive impairment (mean Modified Mini-Mental State Examination score 93.2 out of 100). After adjustment, participants who developed postoperative delirium had performed significantly lower preoperatively on measures of speed of mental processing and divided attention (Trail-Making Test Part B, mean difference 17.55, P=.02), category fluency (animal naming, mean difference -1.94, P=.01), sustained visual attention (Visual Search and Attention, mean difference -3.19, P<.001), and working memory with new learning and recall (Hopkins Verbal Learning Test-Revised Total mean difference -0.53 to -0.79, P<.01).


CONCLUSION
Individuals who later develop delirium have lower scores on tests evaluating the areas of complex attention, executive functioning, and rapid access to verbal knowledge or semantic networks at baseline. Future studies to better understand how the cognitive profiles identified may predispose individuals to developing delirium may help pave the way to greater understanding of the mechanisms of delirium.
Multiple polylogarithms and mixed Tate motives

We develop the theory of multiple polylogarithms from analytic, Hodge and motivic point of view. Define the category of mixed Tate motives over a ring of integers in a number field. Describe explicitly the multiple polylogarithm Hopf algebra.