LLukas22/scidocs huggingface dataset:
SPREE: a spoofing resistant GPS receiver

Global Positioning System (GPS) is used ubiquitously in a wide variety of applications ranging from navigation and tracking to modern smart grids and communication networks. However, it has been demonstrated that modern GPS receivers are vulnerable to signal spoofing attacks. For example, today it is possible to change the course of a ship or force a drone to land in a hostile area by simply spoofing GPS signals. Several countermeasures have been proposed in the past to detect GPS spoofing attacks. These counter-measures offer protection only against naive attackers. They are incapable of detecting strong attackers such as those capable of seamlessly taking over a GPS receiver, which is currently receiving legitimate satellite signals, and spoofing them to an arbitrary location. Also, there is no hardware platform that can be used to compare and evaluate the effectiveness of existing countermeasures in real-world scenarios.
 In this work, we present SPREE, which is, to the best of our knowledge, the first GPS receiver capable of detecting all spoofing attacks described in the literature. Our novel spoofing detection technique called auxiliary peak tracking enables detection of even a strong attacker capable of executing the seamless takeover attack. We implement and evaluate our receiver against three different sets of GPS signal traces: (i) a public repository of spoofing traces, (ii) signals collected through our own wardriving effort and (iii) using commercial GPS signal generators. Our evaluations show that SPREE constraints even a strong attacker (capable of seamless takeover attack) from spoofing the receiver to a location not more than 1 km away from its true location. This is a significant improvement over modern GPS receivers that can be spoofed to any arbitrary location. Finally, we release our implementation and datasets to the community for further research and development.
Enhancing limb salvage by non-mobilized peripheral blood angiogenic cell precursors therapy in patients with critical limb ischemia.

BACKGROUND
Stem cell therapy has been proposed to enhance the salvage of critically ischemic limbs.


OBJECTIVE
Assess the efficacy and safety of the implantation of non-mobilized peripheral blood angiogenic cell precursors (NMPB-ACPs) in patients with critical limb ischemia (CLI) who were poor candidates for standard revascularization treatment options.


MATERIAL AND METHOD
Six patients with CLI due to the infrapopliteal artery occlusive disease were included in the present study. Intramuscular injections of NMPB-ACPs were administered in the ischemic limbs. The efficacy was evaluated by clinical outcomes, ankle brachial index, toe brachial index, and computerized tomographic angiography.


RESULTS
There was no evidence of local or systemic complication related to the procedure. Five patients (83.3%) had clinically significant improvement of adequate circulation at the distal limb for the complete healing. Four of them had complete healing of ischemic ulcers and stumps of toe amputation. However one patient with adequate granulation tissue at the stump of the left first toe amputation subsequently suffered from severe foot infection originating from the other toes and eventually underwent below knee amputation. There was no improvement of circulation at the distal limb after the administration of NMPB-ACPs in one patient (16.7%) who eventually underwent major amputation.


CONCLUSION
The preliminary result of NMPB-ACPs therapy may be safe and provide benefits in the improvement of circulation in patients with CLI. A larger controlled trial is required to ascertain these preliminary results.
On relative errors of floating-point operations: Optimal bounds and applications

Rounding error analyses of numerical algorithms are most often carried out via repeated applications of the so-called standard models of floating-point arithmetic. Given a round-to-nearest function fl and barring underflow and overflow, such models bound the relative errors E1(t) = |t − fl(t)|/|t| and E2(t) = |t − fl(t)|/|fl(t)| by the unit roundoff u. This paper investigates the possibility and the usefulness of refining these bounds, both in the case of an arbitrary real t and in the case where t is the exact result of an arithmetic operation on some floating-point numbers. We show that E1(t) and E2(t) are optimally bounded by u/(1 + u) and u, respectively, when t is real or, under mild assumptions on the base and the precision, when t = x ± y or t = xy with x, y two floating-point numbers. We prove that while this remains true for division in base β > 2, smaller, attainable bounds can be derived for both division in base β = 2 and square root. This set of optimal bounds is then applied to the rounding error analysis of various numerical algorithms: in all cases, we obtain significantly shorter proofs of the best-known error bounds for such algorithms, and/or improvements on these bounds themselves.
Isolating the benefits of fluid restriction in patients with heart failure: A pilot study.

BACKGROUND
Fluid restriction (FR) in persons with heart failure (HF) is often prescribed, yet self-regulation and the troublesome symptom of thirst are difficult for patients to manage.


AIMS
The purpose of this pilot study was to test an educational and behavioral intervention (EBI) on adherence with prescribed FR and outcome measures of fluid congestion, symptom distress, and health related quality of life (HRQL). Secondary aims were to describe the relationships between self-reported and objectively measured determinants of fluid status and symptoms, and assess the psychometric properties of piloted instruments, and intervention effect sizes.


METHODS
NYHA Class II-IV (n=25, 44-83 years, 56% male, 20% minority, mean EF 23.0+11.7%) participants were randomized to the EBI or attention control (AC) and evaluated at baseline, 3 and 6 months.


RESULTS
EBI patients trended toward decreasing fluid ingestion (p=0.08), experienced less HF symptom frequency (p=0.13) and severity (p=0.06), and increased symptoms of thirst (p<0.01) across time. Whereas HRQL remained stable in the EBI group, it improved in the AC group over time (p=0.01). There were no significant differences in clinical measures of fluid congestion between groups.


CONCLUSIONS
These outcomes suggest that patients receiving the EBI drank slightly less fluid, experienced less typical HF symptoms, greater thirst distress and stable HRQOL. Moderate to large effect sizes for the measures used were observed, and outcomes suggest that a randomized trial of various levels of FR would not potentiate fluid congestion but should specifically address preservation of HRQOL and thirst symptoms.
Psychosocial Assessment of Self-Harm Patients and Risk of Repeat Presentation: An Instrumental Variable Analysis Using Time of Hospital Presentation

BACKGROUND
Clinical guidelines have recommended psychosocial assessment of self-harm patients for years, yet estimates of its impact on the risk of repeat self-harm vary. Assessing the association of psychosocial assessment with risk of repeat self-harm is challenging due to the effects of confounding by indication.


METHODS
We analysed data from a cohort study of 15,113 patients presenting to the emergency departments of three UK hospitals to investigate the association of psychosocial assessment with risk of repeat hospital presentation for self-harm. Time of day of hospital presentation was used as an instrument for psychosocial assessment, attempting to control for confounding by indication.


RESULTS
Conventional regression analysis suggested psychosocial assessment was not associated with risk of repeat self-harm within 12 months (Risk Difference (RD) 0.00 95% confidence interval (95%CI) -0.01 to 0.02). In contrast, IV analysis suggested risk of repeat self-harm was reduced by 18% (RD -0.18, 95%CI -0.32 to -0.03) in those patients receiving a psychosocial assessment. However, the instrument of time of day did not remove all potential effects of confounding by indication, suggesting the IV effect estimate may be biased.


CONCLUSIONS
We found that psychosocial assessments reduce risk of repeat self-harm. This is in-line with other non-randomised studies based on populations in which allocation to assessment was less subject to confounding by indication. However, as our instrument did not fully balance important confounders across time of day, the IV effect estimate should be interpreted with caution.
Effect of running therapy on depression (EFFORT-D). Design of a randomised controlled trial in adult patients [ISRCTN 1894]

BACKGROUND
The societal and personal burden of depressive illness is considerable. Despite the developments in treatment strategies, the effectiveness of both medication and psychotherapy is not ideal. Physical activity, including exercise, is a relatively cheap and non-harmful lifestyle intervention which lacks the side-effects of medication and does not require the introspective ability necessary for most psychotherapies. Several cohort studies and randomised controlled trials (RCTs) have been performed to establish the effect of physical activity on prevention and remission of depressive illness. However, recent meta-analysis's of all RCTs in this area showed conflicting results. The objective of the present article is to describe the design of a RCT examining the effect of exercise on depressive patients.


METHODS/DESIGN
The EFFect Of Running Therapy on Depression in adults (EFFORT-D) is a RCT, studying the effectiveness of exercise therapy (running therapy (RT) or Nordic walking (NW)) on depression in adults, in addition to usual care. The study population consists of patients with depressive disorder, Hamilton Rating Scale for Depression (HRSD) ≥ 14, recruited from specialised mental health care. The experimental group receives the exercise intervention besides treatment as usual, the control group receives treatment as usual. The intervention program is a group-based, 1 h session, two times a week for 6 months and of increasing intensity. The control group only performs low intensive non-aerobic exercises. Measurements are performed at inclusion and at 3,6 and 12 months.Primary outcome measure is reduction in depressive symptoms measured by the HRSD. Cardio-respiratory fitness is measured using a sub maximal cycling test, biometric information is gathered and blood samples are collected for metabolic parameters. Also, co-morbidity with pain, anxiety and personality traits is studied, as well as quality of life and cost-effectiveness.


DISCUSSION
Exercise in depression can be used as a standalone or as an add-on intervention. In specialised mental health care, chronic forms of depression, co-morbid anxiety or physical complaints and treatment resistance are common. An add-on strategy therefore seems the best choice. This is the first high quality large trial into the effectiveness of exercise as an add-on treatment for depression in adult patients in specialised mental health care.


TRIAL REGISTRATION
Netherlands Trial Register (NTR): NTR1894.
Activation of agonist and antagonist muscles at different joint angles during maximal isometric efforts

The purpose of this study was to investigate the influence of different angles of the knee joint on the activation level of an agonist (quadriceps femoris muscle) and antagonist (biceps femoris muscle) from electromyographic activities and activation levels (twitch interpolation). Isometric torque measurements were performed on 23 healthy subjects at 10° intervals between 40° and 110° of knee joint flexion. Superimposed twitches at maximal voluntary contraction were applied and the voluntary activation estimated. To quantify the antagonist muscle activity, we normalized its integrated EMG (iEMG) value at each joint angle with respect to its iEMG value at the same angle when acting as an agonist at maximal effort. The activation levels at the knee-flexed position (80–110°) were higher than that at the knee-extended position (40–70°). The co-activation levels at 90, 100, and 110° were significantly higher than that the other knee angle. These results suggest that the activation level of an agonist (quadriceps femoris) muscle and the co-activation level of an antagonist (biceps femoris) muscle were higher in longer muscles than in shorter muscles. It was also concluded that the risk of knee injuries could be reduced by applying these mutual relationships between activation levels of agonist and antagonist muscles.
Collaborative care for patients with bipolar disorder: a randomised controlled trial

BACKGROUND
Bipolar disorder is a severe mental illness with serious consequences for daily living of patients and their caregivers. Care as usual primarily consists of pharmacotherapy and supportive treatment. However, a substantial number of patients show a suboptimal response to treatment and still suffer from frequent episodes, persistent interepisodic symptoms and poor social functioning. Both psychiatric and somatic comorbid disorders are frequent, especially personality disorders, substance abuse, cardiovascular diseases and diabetes. Multidisciplinary collaboration of professionals is needed to combine all expertise in order to achieve high-quality integrated treatment. 'Collaborative Care' is a treatment method that could meet these needs. Several studies have shown promising effects of these integrated treatment programs for patients with bipolar disorder. In this article we describe a research protocol concerning a study on the effects of Collaborative Care for patients with bipolar disorder in the Netherlands.


METHODS/DESIGN
The study concerns a two-armed cluster randomised clinical trial to evaluate the effectiveness of Collaborative Care (CC) in comparison with Care as usual (CAU) in outpatient clinics for bipolar disorder or mood disorders in general. Collaborative Care includes individually tailored interventions, aimed at personal goals set by the patient. The patient, his caregiver, the nurse and the psychiatrist all are part of the Collaborative Care team. Elements of the program are: contracting and shared decision making; psycho education; problem solving treatment; systematic relapse prevention; monitoring of outcomes and pharmacotherapy. Nurses coordinate the program. Nurses and psychiatrists in the intervention group will be trained in the intervention. The effects will be measured at baseline, 6 months and 12 months. Primary outcomes are psychosocial functioning, psychiatric symptoms, and quality of life. Caregiver outcomes are burden and satisfaction with care.


DISCUSSION
Several ways to enhance the quality of this study are described, as well as some limitations caused by the complexities of naturalistic treatment settings where not all influencing factors on an intervention and the outcomes can be controlled.


TRIAL REGISTRATION
The Netherlands Trial Registry, NTR2600.
Engineering design thinking, teaching, and learning

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Open linked data and mobile devices as e-tourism tools. A practical approach to collaborative e-learning

Collaborative e-learning is based on a model where knowledge is created through interaction between members that interact by sharing experiences and knowledge. Linked Open Data (LOD) allow to link data with other related data in which people are interested. As a practical approach we introduce a system where is built cultural heritage knowledge from collaboration between open data published by a regional government, enriched with data from other sources of open linked data cloud like DBPedia. Mobile technologies in e-learning allow learning in any place and moment. We try to take advantage of mobile and semantic technologies, like LOD, in a collaborative e-learning environment. Knowledge is built by enriching open data that are shared by institutions to knowledge shared on Semantic Web, by using LOD techniques, leading a scenario of collaborative and human learning by linking data sources and people who share these data. The collaboration between web of data and open data from a public institution has resulted in practice, in a mobile tourism application that works as a tourist guide for citizens. Application also allows the collaboration of tour guides to add new knowledge about the cultural heritage resources. In brief, collaboration between different profiles generates knowledge and collaborative learning. 2015 Elsevier Ltd. All rights reserved.
Evidence-based radiology: how to quickly assess the validity and strength of publications in the diagnostic radiology literature

The aim of this study was to show how evidence-based medicine (EBM) techniques can be applied to the appraisal of diagnostic radiology publications. A clinical scenario is described: a gastroenterologist has questioned the diagnostic performance of magnetic resonance cholangiopancreatography (MRCP) in a patient who may have common bile duct (CBD) stones. His opinion was based on an article on MRCP published in “Gut.” The principles of EBM are described and then applied to the critical appraisal of this paper. Another paper on the same subject was obtained from the radiology literature and was also critically appraised using explicit EBM criteria. The principles for assessing the validity and strength of both studies are outlined. All statistical parameters were generated quickly using a spreadsheet in Excel format. The results of EBM assessment of both papers are presented. The calculation and application of confidence intervals (CIs) and likelihood ratios (LRs) for both studies are described. These statistical results are applied to individual patient scenarios using graphs of conditional probability (GCP). Basic EBM principles are described and additional points relevant to radiologists discussed. Online resources for EBR practice are identified. The principles of EBM and their application to radiology are discussed. It is emphasized that sensitivity and specificity are point estimates of the “true” characteristics of a test in clinical practice. A spreadsheet can be used to quickly calculate CIs, LRs and GCPs. These give the radiologist a better understanding of the meaning of diagnostic test results in any patient or population of patients.
[Extrapulmonary tuberculosis in Poland in the years 1974-2010].

INTRODUCTION
The incidence of tuberculosis in Poland decreased from 128.5 in 100 000 in 1970 to 19.1 in 100 000 in 2010. In many countries, but not in Poland, according to the improvement of the epidemiological situation of tuberculosis (TB), the proportion of the extrapulmonary form of this disease is increasing. The aim of this study was to describe changes in extrapulmonary TB epidemiology in Poland from 1974 to 2010.


MATERIAL AND METHODS
Retrospective analysis of data from National TB Register on tuberculosis in Poland in the years 1974-2010. The percentage of extrapulmonary tuberculosis among all cases of tuberculosis, the differences in the proportion of extrapulmonary tuberculosis, and differences in various locations of lesions in this form of disease in relation to sex and age groups were assessed. Information was collected from about 626,093 cases of tuberculosis reported to the Register during the period 1972-2010. In 62,251 cases extrapulmonary tuberculosis was the only form of the disease (9.9% of all tuberculosis cases). The study material consisted of 396,344 male and 196,184 female cases; 30,885 subjects were 0-19 years of age, 191,542 were 20-39 years old, 237,256 were 40-59 years old, and 166,410 subjects were ≥ 60 years old. We compared data from the years 1974-1982 with more recent data (2002-2010). The test of proportions for two independent samples was used to assess the significance of differences in proportions.


RESULTS
The proportion of extrapulmonary tuberculosis (EPTB) among all TB cases was 11.2% in the years 1974-1982 and only 8.2% in the years 2002-2010. This difference was significant. The proportion of EPTB among all TB cases was higher in women than in men and was higher in people aged 0-19 years than in other age groups. The location of extrapulmonary tuberculosis was different in women and in men. Pleural TB was the most common form of extrapulmonary tuberculosis in both sexes with a predominance of males. Peripheral lymph nodes, bones and joints, urinary, genital, and skin TB were more common in women (these differences were significant). In the youngest age group intrathoracic lymph node TB dominated, and in the older age groups it was pleural TB. In accordance with the increase in age, the proportion of urinary tract, peripheral node, and pericardium TB increased. Central nervous system TB showed no predilection for a particular age group.


CONCLUSIONS
The proportion of EPTB to all cases of TB is lower in Poland than in other countries. In addition, the proportion of EPTB had significantly decreased from 1974-1982 to 2002-2010. It may be due to difficulties in diagnosis of those forms of TB in Poland. Alternatively it is possible that those cases diagnosed in non-respiratory centres are not reported to the National TB Register.
Testing phase-specific self-efficacy beliefs in the context of dietary behaviour change.

BACKGROUND
Self-efficacy is an important predictor of health behaviour change. Within the health action process approach (HAPA; Schwarzer, 2008), motivational and volitional self-efficacy can be distinguished. Motivational self-efficacy is assumed to serve as predictor of intention formation whereas volitional self-efficacy should be relevant for behaviour change. This study examined these assumptions in a sample with overweight and obese individuals. Moreover, we tested whether behavioural intentions moderate the association between volitional self-efficacy and behaviour.


METHODS
Overall, 373 overweight and obese individuals completed a baseline and six months later a follow-up questionnaire on HAPA variables and dietary behaviour.


RESULTS
A factor analysis confirmed the phase-specific separation of self-efficacy. Motivational self-efficacy emerged as predictor for behavioural intentions over and above other HAPA variables after six months, whereas volitional self-efficacy did not. Volitional self-efficacy interacted with intention in the prediction of behaviour, indicating that volitional self-efficacy is only beneficial for individuals with high levels of intentions.


CONCLUSIONS
The results provide evidence for the phase-specific distinction of self-efficacy in the context of dietary change in an overweight or obese sample. Thus, differentiating between motivational and volitional self-efficacy beliefs should be considered when developing future interventions of dietary change.
Author ' s personal copy Flame synthesis of zinc oxide nanowires

Single-crystalline ZnO nanowires are grown directly on zinc-plated-steel substrates at high rates (microns/minute) using a flame-synthesis method, with no catalysts. The growth of the nanostructures is very sensitive to local gas-phase chemical species concentrations (O2, H2, CO2, H2O) and temperature (800–1500 K) as measured by laser-based spontaneous Raman spectroscopy. Larger-diameter (>100 nm) hexagonal-cross-section nanowires, with [0001] growth direction, are produced at higher temperatures; while smallerdiameter (25–40 nm) nanowires, with 1⁄211 20 growth direction, are produced at lower temperatures, and only on the fuel side of the reaction zone (with no oxygen present). Nanoribbons and other nanowire-based morphologies are also found and discussed. 2007 Elsevier B.V. All rights reserved.