LLukas22/scidocs huggingface dataset:
Are Choice-Making Opportunities Needed in the Classroom? Using Self-Determination Theory to Consider Student Motivation and Learner Empowerment.

Self-determination theory (SDT) underpins research on learner empowerment, but it is rarely discussed in empowerment-related literature. In addition, a motivational measure stemming from SDT has received little visibility in communication research. To address these concerns, this study focuses on motivational theory and measurement in an attempt to tease out the relationship between motivation and learner empowerment as well as how these constructs are related to students’ choicemaking opportunities in the classroom. In essence, this study aims to offer a strong synthesis of the literature related to these constructs, and also to make methodological and practical advancements in understanding student motivation, learner empowerment, and how freedom in the college classroom shapes students’ enthusiasm for learning.
Colchicine reduces postoperative atrial fibrillation: results of the Colchicine for the Prevention of the Postpericardiotomy Syndrome (COPPS) atrial fibrillation substudy.

BACKGROUND
Inflammation and pericarditis may be contributing factors for postoperative atrial fibrillation (POAF), and both are potentially affected by antiinflammatory drugs and colchicine, which has been shown to be safe and efficacious for the prevention of pericarditis and the postpericardiotomy syndrome (PPS). The aim of the Colchicine for the Prevention of the Post-Pericardiotomy Syndrome (COPPS) POAF substudy was to test the efficacy and safety of colchicine for the prevention of POAF after cardiac surgery.


METHODS AND RESULTS
The COPPS POAF substudy included 336 patients (mean age, 65.7±12.3 years; 69% male) of the COPPS trial, a multicenter, double-blind, randomized trial. Substudy patients were in sinus rhythm before starting the intervention (placebo/colchicine 1.0 mg twice daily starting on postoperative day 3 followed by a maintenance dose of 0.5 mg twice daily for 1 month in patients ≥70 kg, halved doses for patients <70 kg or intolerant to the highest dose). The substudy primary end point was the incidence of POAF on intervention at 1 month. Despite well-balanced baseline characteristics, patients on colchicine had a reduced incidence of POAF (12.0% versus 22.0%, respectively; P=0.021; relative risk reduction, 45%; number needed to treat, 11) with a shorter in-hospital stay (9.4±3.7 versus 10.3±4.3 days; P=0.040) and rehabilitation stay (12.1±6.1 versus 13.9±6.5 days; P=0.009). Side effects were similar in the study groups.


CONCLUSION
Colchicine seems safe and efficacious in the reduction of POAF with the potentiality of halving the complication and reducing the hospital stay.
Sedative hypnotic use in Alberta.

OBJECTIVE
Benzodiazepines and similar sedative-hypnotics (BDZ-SSHs) are associated with both beneficial and adverse effects. Pharmacoepidemiologic data describing the use of these medications in contemporary Canadian populations has not been readily available. Our objective was to examine the hypothesis that increasing use of antidepressant medications for anxiety and mood disorders during the past decade led to less frequent use of BDZ-SSH medications.


METHOD
We used data from an Alberta Mental Health Survey to describe the pattern of BDZ-SSH use and to estimate provincial and health region frequencies of use. We supplemented the data with pharmacy dispensing data from IMS Health.


RESULTS
The frequency of use was comparable to that reported in previous studies. Unexpectedly, in the survey data, we observed trends suggesting regional variation both in the frequency and pattern of use. Examination of prescription dispensing data confirmed this pattern. Clinical factors, including the use of other psychotropic medications and psychiatric diagnoses, were strongly associated with BDZ-SSH use. Among the drugs examined, zopiclone had the highest frequency of use. Prescription dispensing data confirmed that the frequency of zopiclone use in Alberta is higher than that in most other provinces.


CONCLUSIONS
This descriptive study generates several new research questions and provides benchmarks for future pharmacoepidemiologic monitoring.
Nicotinic antagonist augmentation of selective serotonin reuptake inhibitor-refractory major depressive disorder: a preliminary study.

BACKGROUND
There is evidence for nicotinic hypercholinergic mechanisms in depression. Clinical relationships between tobacco use and depression suggest important effects of nicotine in major depressive disorder (MDD). It has been hypothesized that cigarette smoking may exert antidepressant effects, presumably mediated through stimulation of nicotinic acetylcholine receptor systems. We compared the nicotinic antagonist, mecamylamine hydrochloride (MEC), with placebo as an augmentation strategy for patients with MDD who were refractory to selective serotonin reuptake inhibitor (SSRI) treatment.


METHODS
Twenty-one SSRI-treated subjects with MDD were randomized to MEC (up to 10 mg/d; n = 11) or placebo (PLO group; n = 10) during an 8-week trial. The primary outcome measure was the change in depressive symptoms assessed using the 17-item Hamilton Depression Rating Scale during the 8-week trial.


RESULTS
There was a significant reduction in 17-item Hamilton Depression Rating Scale scores in the MEC versus PLO groups, as evidenced by a significant medication x time interaction (F1,19 = 6.47, P < 0.05). Five (45.5%) of 11 subjects in the active study medication group demonstrated a 50% or more decrease in depressive symptoms from baseline as compared with 1 (10%) of 10 subjects assigned to placebo medication, but this difference was not significant (P = 0.15; Fisher exact test). The primary side effects of MEC were constipation and orthostatic hypotension.


CONCLUSIONS
These preliminary findings suggest that the nicotinic acetylcholine receptor antagonist, MEC, may have utility as an augmentation strategy for patients with SSRI-refractory MDD.
A predictive model of pathologic response based on tumor cellularity and tumor-infiltrating lymphocytes (CelTIL) in HER2-positive breast cancer treated with chemo-free dual HER2 blockade.

Background
The presence of stromal tumor-infiltrating lymphocytes (TILs) is associated with increased pathologic complete response (pCR) and improved outcomes in HER2-positive early-breast cancer (BC) treated with anti-HER2-based chemotherapy. In the absence of chemotherapy, the association of TILs with pCR following anti-HER2 therapy-only is largely unknown.


Patients and methods
The PAMELA neoadjuvant trial treated 151 women with HER2-positive BC with lapatinib and trastuzumab [and hormonal therapy if hormone receptor (HR)-positive] for 18 weeks. Percentage of TILs and tumor cellularity were determined at baseline (N = 148) and at day 15 (D15) of treatment (N = 134). Associations of TILs and tumor cellularity with pCR in the breast were evaluated. A combined score based on tumor cellularity and TILs (CelTIL) measured at D15 was derived in PAMELA, and validated in D15 samples from 65 patients with HER2-positive disease recruited in the LPT109096 neoadjuvant trial, where anti-HER2 therapy-only was administer for 2 weeks, then standard chemotherapy was added for 24 weeks.


Results
In PAMELA, baseline and D15 TILs were significantly associated with pCR in univariate analysis. In multivariable analysis, D15 TILs, but not baseline TILs, were significantly associated with pCR. At D15, TILs and tumor cellularity were found independently associated with pCR. A combined score (CelTIL) taking into account both variables was derived. CelTIL at D15 as a continuous variable was significantly associated with pCR, and patients with CelTIL-low and CelTIL-high scores had a pCR rate of 0% and 33%, respectively. In LPT109096, CelTIL at D15 was found associated with pCR both as a continuous variable and as group categories using a pre-defined cut-off (75.0% versus 33.3%).


Conclusions
On-treatment TILs, but not baseline TILs, are independently associated with response following anti-HER2 therapy-only. A combined score of TILs and tumor cellularity measured at D15 provides independent predictive information upon completion of neoadjuvant anti-HER2-based therapy.


Clinical trial number
NCT01973660.
Satisfaction with information provided to Danish cancer patients: validation and survey results.

OBJECTIVES
To validate five items (CPWQ-inf) regarding satisfaction with information provided to cancer patients from health care staff, assess the prevalence of dissatisfaction with this information, and identify factors predicting dissatisfaction.


METHODS
The questionnaire was validated by patient-observer agreement and cognitive interviews. The prevalence of dissatisfaction was assessed in a cross-sectional sample of all cancer patients in contact with hospitals during the past year in three Danish counties.


RESULTS
The validation showed that the CPWQ performed well. Between 3 and 23% of the 1490 participating patients were dissatisfied with each of the measured aspects of information. The highest level of dissatisfaction was reported regarding the guidance, support and help provided when the diagnosis was given. Younger patients were consistently more dissatisfied than older patients.


CONCLUSIONS
The brief CPWQ performs well for survey purposes. The survey depicts the heterogeneous patient population encountered by hospital staff and showed that younger patients probably had higher expectations or a higher need for information and that those with more severe diagnoses/prognoses require extra care in providing information.


PRACTICAL IMPLICATIONS
Four brief questions can efficiently assess information needs. With increasing demands for information, a wide range of innovative initiatives is needed.
The HIT study: Hymenoptera Identification Test--how accurate are people at identifying stinging insects?

BACKGROUND
Stinging insects in the order Hymenoptera include bees, wasps, yellow jackets, hornets, and ants. Hymenoptera sting injuries range from localized swelling to rarely death. Insect identification is helpful in the management of sting injuries.


OBJECTIVE
To determine the accuracy of adults in identifying stinging insects and 2 insect nests.


METHODS
This was a cross-sectional, multicenter study using a picture-based survey to evaluate an individual's success at identifying honeybees, wasps, bald-face hornets, and yellow jackets. Bald-face hornet and paper wasp nest identification also was assessed in this study.


RESULTS
Six hundred forty participants completed the questionnaire. Overall, the mean number of correct responses was 3.2 (SD 1.3) of 6. Twenty participants (3.1%) correctly identified all 6 stinging insects and nests and only 10 (1.6%) were unable to identify any of the pictures correctly. The honeybee was the most accurately identified insect (91.3%) and the paper wasp was the least correctly identified insect (50.9%). For the 6 questions regarding whether the participant had been stung in the past by any of the insects (including an unidentified insect), 91% reported being stung by at least 1. Men were more successful at identify stinging insects correctly (P = .002), as were participants stung by at least 4 insects (P = .018).


CONCLUSION
This study supports the general perception that adults are poor discriminators in distinguishing stinging insects and nests with the exception of the honeybee. Men and those participants who reported multiple stings to at least 4 insects were more accurate overall in insect identification.
A case of precocious puberty in a female.

Sexual precocity is considered to be present when indications of genital maturation become apparent in boys before the age of 10 years and in girls before the age of 8 years (Seckel, 1946). It is customary to divide these cases into two groups. In those with true precocious puberty maturation with spermatogenesis or ovulation has occurred in a normal manner, but at an abnormally early age; in those with pseudoprecocious puberty, premature development of the secondary sex organs, but without spermatogenesis or ovulation, has occurred as a result of an ovarian or adreno-cortical tumour, unusual sensitivity of end-organs to normal hormonal stimulation, or exogenous application of sex hormones or other compounds (Talbot, Sobel, McArthur and Crawford, 1952). In a small proportion of cases true precocious puberty is associated with tumours or cysts in the region of the hypothalamus or with post-meningitic or postencephalitic lesions, but in the majority diligent and repeated search fails to reveal any abnormality in the nervous system or endocrine glands (Wilkins, 1957). Such cases are generally referred to as 'idiopathic' or 'constitutional' (Novak, 1944), and it is suggested that the genetic factor or factors that determine the time of hypothalamic sex maturation must be at fault (Seckel, 1946). In a small percentage of cases there is a heredo-familial tendency (Rush, Bilderback, Slocum and Rogers, 1937; Jacobsen and Macklin, 1952). Precocious puberty of idiopathic origin represents simply the early appearance of normal phenomena, and many of the physical and laboratory examinations reveal findings normal for older children (Lloyd, Lobotsky and Morley, 1950). Except for the hazard of precocious pregnancy and the possibility of subnormal stature, the prognosis of girls with idiopathic precocious puberty is good, and it does not appear that the menopause is accelerated or that premature senility occurs (Talbot et al., 1952; Jolly, 1955). The following case of precocious puberty occurring in a female child appears to present features of sufficient interest to warrant publication. Case History
Sentence Reduction for Automatic Text Summarization

We present a novel sentence reduction system for automatically removing extraneous phrases from sentences that are extracted from a document for summarization purpose. The system uses multiple sources of knowledge to decide which phrases in an extracted sentence can be removed, including syntactic knowledge, context information, and statistics computed from a corpus which consists of examples written by human professionals. Reduction can significantly improve the conciseness of automatic summaries.
Enhanced membrane protein topology prediction using a hierarchical classification method and a new scoring function.

The prediction of transmembrane (TM) helix and topology provides important information about the structure and function of a membrane protein. Due to the experimental difficulties in obtaining a high-resolution model, computational methods are highly desirable. In this paper, we present a hierarchical classification method using support vector machines (SVMs) that integrates selected features by capturing the sequence-to-structure relationship and developing a new scoring function based on membrane protein folding. The proposed approach is evaluated on low- and high-resolution data sets with cross-validation, and the topology (sidedness) prediction accuracy reaches as high as 90%. Our method is also found to correctly predict both the location of TM helices and the topology for 69% of the low-resolution benchmark set. We also test our method for discrimination between soluble and membrane proteins and achieve very low overall false positive (0.5%) and false negative rates (0 to approximately 1.2%). Lastly, the analysis of the scoring function suggests that the topogeneses of single-spanning and multispanning TM proteins have different levels of complexity, and the consideration of interloop topogenic interactions for the latter is the key to achieving better predictions. This method can facilitate the annotation of membrane proteomes to extract useful structural and functional information. It is publicly available at http://bio-cluster.iis.sinica.edu.tw/~bioapp/SVMtop.
Amount, type, and sources of carbohydrates in relation to ischemic heart disease mortality in a Chinese population: a prospective cohort study.

BACKGROUND
The relation between carbohydrate intake and risk of ischemic heart disease (IHD) has not been fully explored in Asian populations known to have high-carbohydrate diets.


OBJECTIVE
We assessed whether intakes of total carbohydrates, different types of carbohydrates, and their food sources were associated with IHD mortality in a Chinese population.


DESIGN
We prospectively examined the association of carbohydrate intake and IHD mortality in 53,469 participants in the Singapore Chinese Health Study with an average follow-up of 15 y. Diet was assessed by using a semiquantitative food-frequency questionnaire. HRs and 95% CIs were calculated by using a Cox proportional hazards analysis.


RESULTS
We documented 1660 IHD deaths during 804,433 person-years of follow-up. Total carbohydrate intake was not associated with IHD mortality risk [men: HR per 5% of energy, 0.97 (95% CI: 0.92, 1.03); women: 1.06 (95% CI: 0.99, 1.14)]. When types of carbohydrates were analyzed individually, starch intake was associated with higher risk [men: 1.03 (95% CI: 0.99, 1.08); women: 1.08, (95% CI: 1.02, 1.14)] and fiber intake with lower risk of IHD mortality [men: 0.94 (95% CI: 0.82, 1.08); women: 0.71 (95% CI: 0.60, 0.84)], with stronger associations in women than men (both P-interaction < 0.01). In substitution analyses, the replacement of one daily serving of rice with one daily serving of noodles was associated with higher risk (difference in HR: 26.11%; 95% CI: 10.98%, 43.30%). In contrast, replacing one daily serving of rice with one of vegetables (-23.81%; 95% CI: -33.12%, -13.20%), fruit (-11.94%; 95% CI: -17.49%, -6.00%), or whole-wheat bread (-19.46%; 95% CI: -34.28%, -1.29%) was associated with lower risk of IHD death.


CONCLUSIONS
In this Asian population with high carbohydrate intake, the total amount of carbohydrates consumed was not substantially associated with IHD mortality. In contrast, the shifting of food sources of carbohydrates toward a higher consumption of fruit, vegetables, and whole grains was associated with lower risk of IHD death.
Corporate Social Responsibility , Ethical Leadership , and Trust Propensity : A Multi-Experience Model of Perceived Ethical Climate

Existing research on the formation of employee ethical climate perceptions focuses mainly on organization characteristics as antecedents, and although other constructs have been considered, these constructs have typically been studied in isolation. Thus, our understanding of the context in which ethical climate perceptions develop is incomplete. To address this limitation, we build upon the work of Rupp (Organ Psychol Rev 1:72–94, 2011) to develop and test a multi-experience model of ethical climate which links aspects of the corporate social responsibility (CSR), ethics, justice, and trust literatures and helps to explain how employees’ ethical climate perceptions form. We argue that in forming ethical climate perceptions, employees consider the actions or characteristics of a complex web of actors. Specifically, we propose that employees look (1) outward at how communities are impacted by their organization’s actions (e.g., CSR), (2) upward to make inferences about the ethicality of leaders in their organizations (e.g., ethical leadership), and (3) inward at their own propensity to trust others as they form their perceptions. Using a multiple-wave field study (N = 201) conducted at a privately held US corporation, we find substantial evidence in support of our model.
Caregiving and volunteering: are private and public helping behaviors linked?

OBJECTIVE
The purpose of this study was to examine the relationship between two forms of helping behavior among older adults--informal caregiving and formal volunteer activity.


METHODS
To evaluate our hypotheses, we employed Tobit regression models to analyze panel data from the first two waves of the Americans' Changing Lives survey.


RESULTS
We found that older adult caregivers were more likely to be volunteers than noncaregivers. Caregivers who provided a relatively high number of caregiving hours annually reported a greater number of volunteer hours than did noncaregivers. Caregivers who provided care to nonrelatives were more likely than noncaregivers to be a volunteer and to volunteer more hours. Finally, caregivers were more likely than noncaregivers to be asked to volunteer.


DISCUSSION
Our results provide support for the hypothesis that caregivers are embedded in networks that provide them with more opportunities for volunteering. Additional research on the motivations for volunteering and greater attention to the context and hierarchy of caregiving and volunteering are needed.
Identities in-between: the impact of satellite broadcasting on Greek Orthodox minority (Rum Polites) women's perception of their identities in Turkey

Abstract This study aims to shed a light on women belonging to the Greek Orthodox Christian (Rum Polites) community in Istanbul, Turkey and their perception of their identity with the help of satellite broadcasting (ERT World). This research is the first attempt to analyse Rum women's viewing attitudes and their correlations with a number of variables such as education, age, family structure, religion, occupation, and their perceptions of themselves as part of a distinctive religious and cultural entity. Since the female members of the community are heavy television viewers, television is a powerful tool to construct a social reality and a sense of self. By conducting in-depth interviews and interpretative phenomenological analysis (IPA), this study aims to reveal how this unique community makes sense of their identities and social worlds through television.
Surface modification study of low energy electron beam irradiated polycarbonate film

Abstract The effect of low energy electron beam irradiation on polycarbonate (PC) film has been studied here. The PC film of thickness 20 μm was exposed by 10 keV electron beam with 100 nA/cm 2 current density. The irradiated film was characterized by mean of X-ray photoelectron spectroscopy (XPS), atomic force microscopy (AFM) and residual gas analyzer (RGA). Formation of unsaturated bonds and partial graphitization of the surface layer are measured by XPS. Results of the AFM imaging shows electron implantation induce changes in surface morphology of the polymer film. The residual gas analyzer (RGA) spectrum of PC is recorded in situ during irradiation. The results show the change in cross-linking density of the polymer at the top surface.
Anatomic Distribution of Nerves and Microvascular Density in the Human Anterior Vaginal Wall: Prospective Study

BACKGROUND
The presence of the G-spot (an assumed erotic sensitive area in the anterior wall of the vagina) remains controversial. We explored the histomorphological basis of the G-spot.


METHODS
Biopsies were drawn from a 12 o'clock direction in the distal- and proximal-third areas of the anterior vagina of 32 Chinese subjects. The total number of protein gene product 9.5-immunoreactive nerves and smooth muscle actin-immunoreactive blood vessels in each specimen was quantified using the avidin-biotin-peroxidase assay.


RESULTS
Vaginal innervation was observed in the lamina propria and muscle layer of the anterior vaginal wall. The distal-third of the anterior vaginal wall had significantly richer small-nerve-fiber innervation in the lamina propria than the proximal-third (p = 0.000) and in the vaginal muscle layer (p = 0.006). There were abundant microvessels in the lamina propria and muscle layer, but no small vessels in the lamina propria and few in the muscle layer. Significant differences were noted in the number of microvessels when comparing the distal- with proximal-third parts in the lamina propria (p = 0.046) and muscle layer (p = 0.002).


CONCLUSIONS
Significantly increased density of nerves and microvessels in the distal-third of the anterior vaginal wall could be the histomorphological basis of the G-spot. Distal anterior vaginal repair could disrupt the normal anatomy, neurovascular supply and function of the G-spot, and cause sexual dysfunction.