LLukas22/scidocs huggingface dataset:
Efficacy and safety of olanzapine combined with aprepitant, palonosetron, and dexamethasone for preventing nausea and vomiting induced by cisplatin-based chemotherapy in gynecological cancer: KCOG-G1301 phase II trial

Olanzapine is effective in chemotherapy-induced nausea and vomiting (CINV). In patients receiving highly emetogenic chemotherapy (HEC), its efficacy was reported as rescue therapy for breakthrough emesis refractory to triplet therapy (palonosetron, aprepitant, and dexamethasone). However, its preventive effects with triplet therapy for CINV are unknown. This study aimed to investigate efficacy and safety of preventive use of olanzapine with triplet therapy for CINV of HEC. This study is a prospective multicenter study conducted by Kansai Clinical Oncology Group. Forty chemo-naïve gynecological cancer patients receiving HEC with cisplatin (≥50 mg/m2) were enrolled. Oral olanzapine (5 mg) was administered with triplet therapy a day prior to cisplatin administration and on days 1–5. The primary endpoint was complete response (no vomiting and no rescue) rate for the overall phase (0–120 h post-chemotherapy). Secondary endpoints were complete response rate for acute phase (0–24 h post-chemotherapy) and delayed phase (24–120 h post-chemotherapy) and complete control (no vomiting, no rescue, and no significant nausea) rate and total control (no vomiting, no rescue, and no nausea) rate for each phase. These endpoints were evaluated during the first cycle of chemotherapy. Complete response rates for acute, delayed, and overall phases were 97.5, 95.0, and 92.5 %, respectively. Complete control rates were 92.5, 87.5, and 82.5 %, respectively. Total control rates were 87.5, 67.5, and 67.5 %, respectively. There were no grade 3 or 4 adverse events. Preventive use of olanzapine combined with triplet therapy gives better results than those from previously reported studies of triplet therapy.
Population-Scale Sequencing Data Enable Precise Estimates of Y-STR Mutation Rates.

Short tandem repeats (STRs) are mutation-prone loci that span nearly 1% of the human genome. Previous studies have estimated the mutation rates of highly polymorphic STRs by using capillary electrophoresis and pedigree-based designs. Although this work has provided insights into the mutational dynamics of highly mutable STRs, the mutation rates of most others remain unknown. Here, we harnessed whole-genome sequencing data to estimate the mutation rates of Y chromosome STRs (Y-STRs) with 2-6 bp repeat units that are accessible to Illumina sequencing. We genotyped 4,500 Y-STRs by using data from the 1000 Genomes Project and the Simons Genome Diversity Project. Next, we developed MUTEA, an algorithm that infers STR mutation rates from population-scale data by using a high-resolution SNP-based phylogeny. After extensive intrinsic and extrinsic validations, we harnessed MUTEA to derive mutation-rate estimates for 702 polymorphic STRs by tracing each locus over 222,000 meioses, resulting in the largest collection of Y-STR mutation rates to date. Using our estimates, we identified determinants of STR mutation rates and built a model to predict rates for STRs across the genome. These predictions indicate that the load of de novo STR mutations is at least 75 mutations per generation, rivaling the load of all other known variant types. Finally, we identified Y-STRs with potential applications in forensics and genetic genealogy, assessed the ability to differentiate between the Y chromosomes of father-son pairs, and imputed Y-STR genotypes.
HTS DC Cable Line Project: On-Going Activities in Russia

Previous research has shown that implementing high-temperature superconducting dc power cables in electrical grids of large metropolitan areas will have major positive impacts on power system operation and control. Current activities in Russia comprise developing a 2.5-km high-temperature superconducting dc cable and its installation in St. Petersburg electrical grid. This work includes five major parts: installation site selection, cable calculation, development and manufacturing, cryogenic equipment development, ac/dc converter development, and testing of all dc line elements. As of today, the list of subcontractors has been approved. The purpose of this report is to summarize current results and future work.
Nile River sediment fluctuations over the past 7000 yr and their key role in sapropel development

The provenance pattern of Nile River sediments can be used as a proxy for paleoclimatic changes in East Africa. The 87Sr/86Sr ratios are particularly appropriate for such provenance investigations, because the White Nile drains predominantly crystalline basement rocks, whereas the Blue Nile and Atbara flow off the Ethiopian Highlands, which consist of Tertiary volcanic rocks. A high-resolution profile of 87Sr/86Sr and Ti/Al ratios from a well-dated core in the Nile Delta shows a close correspondence with known changes in Nile flow over the past 7000 yr. At times of higher river flow there was markedly decreased input of Blue Nile–derived and total sediment. This change was caused by northward movement of the Inter Tropical Convergence Zone, resulting in increased vegetative cover in the Ethiopian Highlands due to higher rainfall and a longer wet season. This inverse relationship between Nile River flow and sediment flux may have had important implications in the development of agricultural technology in ancient Egypt. The marked minimum in 87Sr/86Sr at 4200–4500 yr B.P. is coincident with the end of the Old Kingdom in Egypt and provides independent evidence that demise of the Old Kingdom might have been associated with an extended period of catastrophic low floods. During the Quaternary and late Neogene, there was periodic deposition of organic-rich sediments (sapropels) in the eastern Mediterranean that represent important indicators of major environmental change. Evidence from the Ti/Al ratio suggests that the pattern of erosion and sediment supply from the Nile catchment observed in this study also occurred throughout much of the Neogene and Quaternary. The reduced inputs of Blue Nile sediment during times of sapropel formation contributed to the increased primary productivity by reducing the amount of phosphate removed on particles and to the observed change to N limitation in the eastern Mediterranean, which are important characteristics of sapropel deposition.
Compressive deformation of wood impregnated with low molecular weight phenol formaldehyde (PF) resin I: effects of pressing pressure and pressure holding

The deformation behavior of low molecular weight phenol formaldehyde (PF) resin-impregnated wood under compression in the radial direction was investigated for obtaining high-strength wood at low pressing pressures. Flat-sawn grain Japanese cedar (Cryptomeria japonica) blocks with a density of 0.34 g/cm3 were treated with aqueous solution of 20% low molecular weight PF resin resulting in weight gain of 60.8%. Oven-dried specimens were compressed using hot plates fixed to a testing machine. The temperature was 150°C and the pressing speed was 5 mm/min. The impregnation of PF resin caused significant softening of the cell walls resulting in collapse at low pressures. The cell wall collapse was strain-dependent and occurred at a strain of 0.05–0.06 mm/mm regardless of whether the wood was treated with PF resin. Thus, pressure holding causing creep deformation of the cell walls was also effective in initiating cell wall collapse at low pressure. Utilizing a combination of low molecular weight PF resin impregnation and pressure holding at 2 MPa resulted in a density increase of PF resin-treated wood from 0.45 to 1.1 g/cm3. At the same time, the Young’s modulus and bending strength increased from 10 GPa to 22 GPa and 80 MPa to 250 MPa, respectively. It can be concluded that effective utilization of the collapse region of the cell wall is a desirable method for obtaining high-strength PF resin-impregnated wood at low pressing pressures.
pi-ADL: an Architecture Description Language based on the higher-order typed pi-calculus for specifying dynamic and mobile software architectures

A key aspect of the design of any software system is its architecture. An architecture description, from a runtime perspective, should provide a formal specification of the architecture in terms of components and connectors and how they are composed together. Further, a dynamic or mobile architecture description must provide a specification of how the architecture of the software system can change at runtime. Enabling specification of dynamic and mobile architectures is a large challenge for an Architecture Description Language (ADL). This article describes π-ADL, a novel ADL that has been designed in the ArchWare European Project to address specification of dynamic and mobile architectures. It is a formal, well-founded theoretically language based on the higher-order typed π-calculus. While most ADLs focus on describing software architectures from a structural viewpoint, π-ADL focuses on formally describing architectures encompassing both the structural and behavioural viewpoints. The π-ADL design principles, concepts and notation are presented. How π-ADL can be used for specifying static, dynamic and mobile architectures is illustrated through case studies. The π-ADL toolset is outlined.
The Mixmaster Universe in Five Dimensions

We consider a five dimensional vacuum cosmology with Bianchi type-IX spatial geometry and an extra non-compact coordinate. Finding a new class of solutions, we examine and rule out the possibility of deterministic chaos. We interpret this result within the context of induced matter theory.
Types of Social Capital and Mental Disorder in Deprived Urban Areas: A Multilevel Study of 40 Disadvantaged London Neighbourhoods

OBJECTIVES
To examine the extent to which individual and ecological-level cognitive and structural social capital are associated with common mental disorder (CMD), the role played by physical characteristics of the neighbourhood in moderating this association, and the longitudinal change of the association between ecological level cognitive and structural social capital and CMD.


DESIGN
Cross-sectional and longitudinal study of 40 disadvantaged London neighbourhoods. We used a contextual measure of the physical characteristics of each neighbourhood to examine how the neighbourhood moderates the association between types of social capital and mental disorder. We analysed the association between ecological-level measures of social capital and CMD longitudinally.


PARTICIPANTS
4,214 adults aged 16-97 (44.4% men) were randomly selected from 40 disadvantaged London neighbourhoods.


MAIN OUTCOME MEASURES
General Health Questionnaire (GHQ-12).


RESULTS
Structural rather than cognitive social capital was significantly associated with CMD after controlling for socio-demographic variables. However, the two measures of structural social capital used, social networks and civic participation, were negatively and positively associated with CMD respectively. 'Social networks' was negatively associated with CMD at both the individual and ecological levels. This result was maintained when contextual aspects of the physical environment (neighbourhood incivilities) were introduced into the model, suggesting that 'social networks' was independent from characteristics of the physical environment. When ecological-level longitudinal analysis was conducted, 'social networks' was not statistically significant after controlling for individual-level social capital at follow up.


CONCLUSIONS
If we conceptually distinguish between cognitive and structural components as the quality and quantity of social capital respectively, the conclusion of this study is that the quantity rather than quality of social capital is important in relation to CMD at both the individual and ecological levels in disadvantaged urban areas. Thus, policy should support interventions that create and sustain social networks. One of these is explored in this article.


TRIAL REGISTRATION
Controlled-Trials.com ISRCTN68175121 http://www.controlled-trials.com/ISRCTN68175121.
Algorithm 457: finding all cliques of an undirected graph

Description bttroductian. A maximal complete subgraph (clique) is a complete subgraph that is not contained in any other complete subgraph. A recent paper [1] describes a number of techniques to find maximal complete subgraphs of a given undirected graph. In this paper, we present two backtracking algorithms, using a branchand-bound technique [4] to cut off branches that cannot lead to a clique. The first version is a straightforward implementation of the basic algorithm. It is mainly presented to illustrate the method used. This version generates cliques in alphabetic (lexicographic) order. The second version is derived from the first and generates cliques in a rather unpredictable order in an attempt to minimize the number of branches to be traversed. This version tends to produce the larger cliques first and to generate sequentially cliques having a large common intersection. The detailed algorithm for version 2 is presented here. Description o f the algorithm--Version 1. Three sets play an important role in the algorithm. (1) The set compsub is the set to be extended by a new point or shrunk by one point on traveling along a branch of the backtracking tree. The points that are eligible to extend compsub, i.e. that are connected to all points in compsub, are collected recursively in the remaining two sets. (2) The set candidates is the set of all points that will in due time serve as an extension to the present configuration of compsub. (3) The set not is the set of all points that have at an earlier stage already served as an extension of the present configuration of compsub and are now explicitly excluded. The reason for maintaining this set trot will soon be made clear. The core of the algorithm consists of a recursively defined extension operator that will be applied to the three sets Just described. It has the duty to generate all extensions of the given configuration of compsub that it can make with the given set of candidates and that do not contain any of the points in not. To put it differently: all extensions of compsub containing any point in not have already been generated. The basic mechanism now consists of the following five steps:
Efficacy and safety of mildronate for acute ischemic stroke: a randomized, double-blind, active-controlled phase II multicenter trial.

BACKGROUND AND OBJECTIVE
Mildronate, an inhibitor of carnitine-dependent metabolism, is considered to be an anti-ischemic drug. This study is designed to evaluate the efficacy and safety of mildronate injection in treating acute ischemic stroke.


METHODS
We performed a randomized, double-blind, multicenter clinical study of mildronate injection for treating acute cerebral infarction. 113 patients in the experimental group received mildronate injection, and 114 patients in the active-control group received cinepazide injection. In addition, both groups were given aspirin as a basic treatment. Modified Rankin Scale (mRS) score was performed at 2 weeks and 3 months after treatment. National Institutes of Health Stroke Scale (NIHSS) score and Barthel Index (BI) score were performed at 2 weeks after treatment, and then vital signs and adverse events were evaluated.


RESULTS
A total of 227 patients were randomized to treatment (n = 113, mildronate; n = 114, active-control). After 3 months, there was no significant difference for the primary endpoint between groups categorized in terms of mRS scores of 0-1 and 0-2 (p = 0.52 and p = 0.07, respectively). There were also no significant differences for the secondary endpoint between groups categorized in terms of NIHSS scores of >5 and >8 (p = 0.98 and p = 0.97, respectively) or BI scores of >75 and >95 (p = 0.49 and p = 0.47, respectively) at 15 days. The incidence of serious adverse events was similar between the two groups.


CONCLUSION
Mildronate injection is as effective and safe as cinepazide injection in treating acute cerebral infarction.
Erectile dysfunction in men receiving methadone and buprenorphine maintenance treatment.

INTRODUCTION
Use of opiates/opioids is associated with hypoactive sexual desire, erectile and orgasmic dysfunction.


AIM
To determine prevalence and investigate etiology of sexual dysfunction in men on methadone or buprenorphine maintenance treatment (MMT, BMT).


MAIN OUTCOME MEASURES
International Index of Erectile Function (IIEF), hormone assays, Beck Depression Inventory.


METHODS
A total of 103 men (mean age 37.6 +/- 7.9) on MMT (N = 84) or BMT (N = 19) were evaluated using the IIEF, hormone assays, Beck Depression Inventory, body mass index (BMI), demographic, and other substance use measures.


RESULTS
Mean total IIEF scores for partnered men were lower for MMT (50.4 +/- 18.2; N = 53) than reference groups (61.4 +/- 16.8; N = 415; P < 0.0001) or BMT (61.4 +/- 7.0; N = 14; P = 0.048). Among partnered men on MMT, 53% had erectile dysfunction (ED) compared with 24% of reference groups; 26% had moderate to severe ED, 12.1% in under 40s and 40.0% among those 40+ years. On multiple regression, depression, older age, and lower total testosterone were associated with lower IIEF and EF domain; on multivariate analysis, there were no significant associations between IIEF or EF and free testosterone, opioid dose, cannabis or other substance use, viral hepatitis, or BMI. Total testosterone accounted for 16% of IIEF and 15% of EF variance. Men without sexual partners had lower Desire and Erection Confidence scores and less recent sexual activity, suggesting potentially higher prevalence of sexual dysfunction in this group.


CONCLUSION
Men on MMT, but not BMT, have high prevalence of ED, related to hypogonadism and depression. Practitioners should screen for sexual dysfunction in men receiving opioid replacement treatment. Future studies of sexual dysfunction in opioid-treated men should examine the potential benefits of dose reduction, androgen replacement, treatment of depression, and choice of opioid.
Designing the process design process

We suggest that designing design processes is an ill-posed problem which must be tackled with great care and in an evolutionary fashion. We argue it is an important activity, however, as companies today use a small percentage of the intellectual capital they own when designing, suggesting there is room for significant improvement. We discuss who in industry and academia are currently involved with designing design processes. Based on empirical studies we and others have carried out, we have based our approach to study and support design processes on managing the information they generate and use. We are learning how to carry out studies more effectively with industrial partners, what features we need for managing information to study and improve design processes. We are even learning some general observations about the effect of different behavior of the group on its success at designing. 1. Department of Chemical Engineering, Carnegie Mellon University 2. Engineering Design Research Center, Carnegie Mellon University 3. Dept. of Solid Mechanics, Materials and Structures, Faculty of Engineering, Tel Aviv University 4. The current n-dim group comprises: Douglas P. Cunningham, Allen H. Dutoit, Helen L. Granger, Suresh Konda, K. C. Marshall, Russell C. Milliken, Ira A. Monarch, J. Peter Neergaard, Robert H. Patrick, Yoram Reich, Eswaran Subrahmanian, Mark E. Thomas, Arthur W. Westerberg
The role of infant sleep in intergenerational transmission of trauma.

INTRODUCTION
Children of parents who experienced trauma often present emotional and behavioral problems, a phenomenon named inter-generational transmission of trauma (IGTT). Combined with antenatal factors, parenting and the home environment contribute to the development and maintenance of sleep problems in children. In turn, infant sleep difficulty predicts behavioral and emotional problems later in life. The aim of this study was to investigate whether infant sleep problems predict early behavioral problems indicative of IGTT.


METHODS
184 first-time mothers (ages 18-47) participated. N=83 had a history of childhood abuse and posttraumatic stress disorder (PTSD+); 38 women reported childhood abuse but did not meet diagnostic criteria for PTSD (PTSD-); and the control group (N=63) had neither a history of abuse nor psychopathology (CON). Depression, anxiety, and sleep difficulty were assessed in the mothers at 4 months postpartum. Infant sleep was assessed using the Child Behavior Sleep Questionnaire (CSHQ). Outcome measures included the Parent Bonding Questionnaire (PBQ) at 4 months and the Child Behavior Check List (CBCL) at 18 months.


RESULTS
Infants of PTSD+ mothers scored higher on the CSHQ and had more separation anxiety around bedtime than PTSD- and CON, and the severity of their symptoms was correlated with the degree of sleep disturbance. Maternal postpartum depression symptoms mediated impaired mother-infant bonding, while infant sleep disturbance contributed independently to impaired bonding. Mother-infant bonding at 4 months predicted more behavioral problems at 18 months.


CONCLUSIONS
Infant sleep difficulties and maternal mood play independent roles in infant-mother bonding disturbance, which in turn predicts behavioral problems at 18 months.
One-year follow-up evaluation of Project Towards No Drug Abuse (TND-4).

OBJECTIVES
This paper describes the one-year outcomes of the fourth experimental trial of Project Towards No Drug Abuse. Two theoretical content components of the program were examined to increase our understanding of the relative contribution of each to the effectiveness of the program.


METHODS
High schools in Southern California (n=18) were randomly assigned to one of three conditions: cognitive perception information curriculum, cognitive perception information+behavioral skills curriculum, or standard care (control). The curricula were delivered to high school students (n=2734) by project health educators and regular classroom teachers. Program effectiveness was assessed with both dichotomous and continuous measures of 30-day substance use at baseline and one-year follow-up.


RESULTS
Across all program schools, the two different curricula failed to significantly reduce dichotomous measures of substance use (cigarette, alcohol, marijuana, and hard drugs) at one-year follow-up. Both curricula exerted an effect only on the continuous measure of hard drug use, indicating a 42% (p=0.02) reduction in the number of times hard drugs were used in the last 30 days in the program groups relative to the control.


CONCLUSIONS
The lack of main effects of the program on dichotomous outcomes was contrary to previous studies. An effect on an ordinal count measure of hard drug use among both intervention conditions replicates previous work and suggests that this program effect may have been due to changes in cognitive misperception of drug use rather than behavioral skill.
The division of the world, 1941-1955

This book should be of interest to students of twentieth century history from introductory to research level. The text argues that neither "Soviet Expansionism" nor "American Imperialism" can be seen as the central factor of the Cold War.