Recent Trends in the Development of Oral dissolving Film

Oral dissolving films are formulated by incorporating the drug with selected oral cavity absorption enhancers in a specially designed oral dissolving film carriers. This facilitates the rapid absorption in the oral cavity for drugs with low GIT-bioavailability and intensive first-pass effects. This it offers shortening onset time, enhancing bioavailability and reducing the probability of first pass side effect. The current review focuses on the recent development in the oral dissolving film and discusses about its technique for preparation of film as well its evaluation. Key word: Oral dissolving film, Film forming polymer, Solvent casting technique, Buccal cavity. INTRODUCTION Some patients have difficulties in swallowing or chewing solid dosage which forms risk or fear of chocking so this is a major problem in the use of tablets. Oral dissolving film is a new drug delivery system for oral delivery of drug. Oral film a type of film which is used in acute condition such as pain, antiemetic, anti-migraine, anti-hypertension, congestive heart failure, and Asthma etc. oral dissolving film has gained popularity due to its availability in various size and shape Oral dissolving films are intended to disintegrate or dissolve within seconds. They offer advantages such as administration without water, rapid onset of action and convenience of dosing. For fast dissolving active pharmaceutical ingredients absorption is possible through the oral mucosa and may improve bioavailability The concept of oral dissolves film • This delivery system consists of a thin film. • After placing it on the top of the tongue, the film dissolves within seconds, promoting first pass metabolism as compared to tablet and other immediate release oral solid dosage forms, and may increase the bioavailability of drug 3. • FDF dissolves in the mouth like a cotton candy. Advantages of oral dissolving film (ODF) over fast dissolving tablet (FDT) • Accessibility of larger surface area that leads to quickly disintegrate and dissolution in the oral cavity within seconds . • ODF is flexible so they are not as fragile and need not any kind of special package for protection during transportation and storage as compared to FDT. • No need of water has led to better satisfactoriness amongst the dysphasic patients. • No fear of chocking as compared to FDT. • The large surface area available in the film dosage form allows rapid wettive by saliva then quickly disintegrates and dissolve and absorbed directly and can enter the systemic circulation without undergoing first-pass hepatic metabolism and on increase the bioavailability . • The dosage form can be consumed at any place and any time as per convenience of the individual. Shweta Kalyan et al /Int.J. PharmTech Res.2012,4(2) 726 • The first pass effect can be avoided, so a reduction in the dose which can lead to reduction in side effects associated with the molecule . • Patients suffering from dysphagia, repeated emesis, hypertension, heart attack, asthma, motion sickness, paralysis and mental disorders prefer this dosage form as they are not capable to swallow large quantities of water. FORMULATION FOR FILM The area of drug loaded film should be between 1-20 cm which depends on the amount of water-soluble polymers that are responsible for rapid disintegration. Table shows: Composition of fast dissolving film 7 S. No. INGREDIENTS AMOUNT (w/w) 1 Active pharmaceutical ingredients 5 to30% 2 Water soluble polymer 45% 3 Plasticizer 0 to20% 4 Saliva stimulating agent 2 to 6%