LLukas22/scidocs huggingface dataset:
Overlap of disease susceptibility loci for rheumatoid arthritis and juvenile idiopathic arthritis

BACKGROUND
Genome-wide association studies (GWAS) have been extremely successful in the search for susceptibility risk factors for complex genetic autoimmune diseases. As more studies are published, evidence is emerging of considerable overlap of loci between these diseases. In juvenile idiopathic arthritis (JIA), another complex genetic autoimmune disease, the strategy of using information from autoimmune disease GWAS or candidate gene studies to help in the search for novel JIA susceptibility loci has been successful, with confirmed association with two genes, PTPN22 and IL2RA. Rheumatoid arthritis (RA) is an autoimmune disease that shares similar clinical and pathological features with JIA and, therefore, recently identified confirmed RA susceptibility loci are also excellent JIA candidate loci.


OBJECTIVE
To determine the overlap of disease susceptibility loci for RA and JIA.


METHODS
/st> Fifteen single nucleotide polymorphisms (SNPs) at nine RA-associated loci were genotyped in Caucasian patients with JIA (n=1054) and controls (n=3531) and tested for association with JIA. Allele and genotype frequencies were compared between cases and controls using the genetic analysis software, PLINK.


RESULTS
Two JIA susceptibility loci were identified, one of which was a novel JIA association (STAT4) and the second confirmed previously published associations of the TRAF1/C5 locus with JIA. Weak evidence of association of JIA with three additional loci (Chr6q23, KIF5A and PRKCQ) was also obtained, which warrants further investigation.


CONCLUSION
All these loci are good candidates in view of the known pathogenesis of JIA, as genes within these regions (TRAF1, STAT4, TNFAIP3, PRKCQ) are known to be involved in T-cell receptor signalling or activation pathways.
DC Bus Capacitor Discharge of Permanent-Magnet Synchronous Machine Drive Systems for Hybrid Electric Vehicles

This paper investigates control methods to quickly and safely discharge the high-voltage dc bus capacitor for the permanent-magnet synchronous machine drive systems of hybrid electric vehicles during emergency situations such as a crash event. The published dc bus capacitor discharge strategies either need impractically heavy and bulky hardware or are only effective for low machine speeds. Applying the existing methods under high speeds will lead to loss of the current control and a system shutdown, followed by the bus voltage recharging again. The proposed new control method applies a modulation index controller together with a bus voltage regulator to quickly discharge the bus voltage and avoid any bus recharge regardless of the electric machine speed. Simulation and experimental results are presented to verify the effectiveness of the proposed control algorithm.
Hypnotic approaches for chronic pain management: clinical implications of recent research findings.

The empirical support for hypnosis for chronic pain management has flourished over the past two decades. Clinical trials show that hypnosis is effective for reducing chronic pain, although outcomes vary between individuals. The findings from these clinical trials also show that hypnotic treatments have a number of positive effects beyond pain control. Neurophysiological studies reveal that hypnotic analgesia has clear effects on brain and spinal-cord functioning that differ as a function of the specific hypnotic suggestions made, providing further evidence for the specific effects of hypnosis. The research results have important implications for how clinicians can help their clients experience maximum benefits from hypnosis and treatments that include hypnotic components.
Microstrip Patch Antenna with Defected Ground Structure for Bandwidth Enhancement

In this paper, a new Defected Ground Structure (DGS) consisting of I-shape slot in ground has been presented to enhance the bandwidth of the Microstrip Patch Antenna (MPA). The parameters such as Bandwidth, Return loss and VSWR are much improved in proposed antenna than simple MPA without defected ground structure. Finite Element Machine (FEM) based High Frequency Structure Simulator (HFSS) software Version-13.0 is used to obtain the performance parameters of the proposed antenna. A comparison is also shown for the proposed antenna with the antenna structure without defect. The proposed antenna resonates in C-band at frequency of 6.0718 GHz with bandwidth of 132.3 MHz. A very good return loss of -46.75 dB is obtained for I-Shaped Defected Ground Structure (DGS). Also I-shaped DGS in the ground plane found to give a size reduction of about 5%.
Catecholamine-resistant hypotension and myocardial performance following patent ductus arteriosus ligation

Objective:We performed a multicenter study of preterm infants, who were about to undergo patent ductus arteriosus ligation, to determine whether echocardiographic indices of impaired myocardial performance were associated with subsequent development of catecholamine-resistant hypotension following ligation.Study Design:A standardized treatment approach for hypotension was followed at each center. Infants were considered to have catecholamine-resistant hypotension if their dopamine infusion was >15 μg kg–1min–1. Echocardiograms and cortisol measurements were obtained between 6 and 14 h after the ligation (prior to the presence of catecholamine-resistant hypotension).Result:Forty-five infants were enrolled, 10 received catecholamines (6 were catecholamine-responsive and 4 developed catecholamine-resistant hypotension). Catecholamine-resistant hypotension was not associated with decreased preload, shortening fraction or ventricular output. Infants with catecholamine-resistant hypotension had significantly lower levels of systemic vascular resistance and postoperative cortisol concentration.Conclusion:We speculate that low cortisol levels and impaired vascular tone may have a more important role than impaired cardiac performance in post-ligation catecholamine-resistant hypotension.
Noninvasive Brain-Computer Interfaces Based on Sensorimotor Rhythms

Brain-computer interfaces (BCIs) have been explored in the field of neuroengineering to investigate how the brain can use these systems to control external devices. We review the principles and approaches we have taken to develop a sensorimotor rhythm electroencephalography (EEG)-based brain-computer interface (BCI). The methods include developing BCI systems incorporating the control of physical devices to increase user engagement, improving BCI systems by inversely mapping scalp-recorded EEG signals to the cortical source domain, integrating BCI with noninvasive neuromodulation strategies to improve learning, and incorporating mind-body awareness training to enhance BCI learning and performance. The challenges and merits of these strategies are discussed, together with recent findings. Our work indicates that the sensorimotor-rhythm-based noninvasive BCI has the potential to provide communication and control capabilities as an alternative to physiological motor pathways.
Salivary cortisol and psychological mechanisms in patients with acute versus chronic low back pain

This study was designed to explore whether the basal adrenocortical activity is related with pain-related coping, nonverbal pain behavior, depressive mood, and fatigue in patients with acute and chronic nonspecific low back pain. 19 patients with acute low back pain (ALBP) and 24 with chronic low back pain (CLBP) participated in the study. The adrenocortical activity was assessed through the cortisol awakening response. All participants provided five saliva samples (0, 15, 30, 45, and 60min after waking) on two consecutive days off work. Pain-related coping [fear-avoidance coping (FAC) and endurance coping (EC)], nonverbal pain behavior (NPB), depressive mood, and fatigue were assessed through questionnaires. Among ALPB patients, EC was negatively associated with the cortisol release, whereas fatigue was positively associated with it. Among CLBP patients, FAC, NPB, depressive mood, and fatigue were negatively associated with the cortisol awakening response, whereas EC tended to be positively associated with it. The results indicate that pain-related coping strategies which are expected to be successful appear to lower the adrenocortical activity among ALBP patients, whereas affective distress may enhance the level of cortisol in this group. Among CLBP patients, long-term maladaptive coping strategies might contribute to hypocortisolism.
THE GEOMETRY OF OPTIMAL TRANSPORTATION

A classical problem of transporting mass due to Monge and Kantorovich is solved. Given measures μ and ν on Rd, we find the measure-preserving map y(x) between them with minimal cost — where cost is measured against h(x − y) with h strictly convex, or a strictly concave function of |x − y|. This map is unique: it is characterized by the formula y(x) = x − (∇h)−1(∇ψ(x)) and geometrical restrictions on ψ. Connections with mathematical economics, numerical computations, and the Monge-Ampère equation are sketched. ∗Both authors gratefully acknowledge the support provided by postdoctoral fellowships: WG at the Mathematical Sciences Research Institute, Berkeley, CA 94720, and RJM from the Natural Sciences and Engineering Research Council of Canada. c ©1995 by the authors. To appear in Acta Mathematica 1997.
C-reactive protein levels determine systemic nitric oxide bioavailability in patients with coronary artery disease.

AIM
Elevated C-reactive protein (CRP) levels are associated with impaired endothelial vasoreactivity in patients with coronary artery disease (CAD). Because inflammatory cytokines experimentally reduce basal and stimulated endothelial nitric oxide (NO) release, we hypothesised that patients with elevated CRP-levels are characterised by a systemic impairment in NO bioavailability.


METHODS AND RESULTS
Forearm blood flow (FBF) responses were measured by venous occlusion plethysmography in 75 male patients with documented CAD. Inhibition of NO synthesis by infusion of L-NMMA significantly reduced baseline FBF (2.2 +/- 0.5 vs. 1.9 +/- 0.5 mL/min/100 mL of forearm tissue, P < 0.001) and acetylcholine-stimulated FBF responses (AUC: 35.0 +/- 16.0 vs. 25.9 +/- 11.9; P < 0.001). CRP serum levels were inversely correlated with L-NMMA-induced decreases in baseline as well as acetylcholine-stimulated FBF responses. Co-infusion of the oxygen-derived free radical scavenger vitamin C significantly increased baseline FBF from 2.0 +/- 0.5 to 2.5 +/- 0.7 (mL/min/100 mL forearm tissue (P < 0.001)) and acetylcholine-stimulated FBF responses in patients with elevated CRP, but not in patients with low CRP serum levels. Vitamin C-induced increases in baseline FBF and in acetylcholine-stimulated FBF responses were significantly correlated with CRP serum levels. By multivariable analysis, CRP serum levels remained the only statistically significant independent predictor of NO bioavailability in the systemic circulation of patients with CAD.


CONCLUSIONS
In patients with CAD, low grade systemic inflammation is associated with increased in vivo oxidative stress leading to impaired systemic bioavailability of NO, which might significantly contribute to the transition from stable coronary artery disease to acute coronary syndromes.
A Survey of Neural Network Techniques for Feature Extraction from Text

This paper aims to catalyze research discussions about text feature extraction techniques using neural network architectures. The research questions discussed here focus on the state-of-the-art neural network techniques that have proven to be useful tools for language processing, language generation, text classification and other computational linguistics tasks.
Real-time emotion recognition for gaming using deep convolutional network features

The goal of the present study is to explore the application of deep convolutional network features to emotion recognition. Results indicate that they perform similarly to recently published models at a best recognition rate of 94.4%, and do so with a single still image rather than a video stream. An implementation of an affective feedback game is also described, where a classifier using these features tracks the facial expressions of a player in real-time. Keywords—emotion recognition, convolutional network, affective computing
Primary prevention implantable cardioverter-defibrillators in older racial and ethnic minority patients.

BACKGROUND
Racial and ethnic minorities are under-represented in clinical trials of primary prevention implantable cardioverter-defibrillators (ICDs). This analysis investigates the association between primary prevention ICDs and mortality among Medicare, racial/ethnic minority patients.


METHODS AND RESULTS
Data from Get With The Guidelines-Heart Failure Registry and National Cardiovascular Data Registry's ICD Registry were used to perform an adjusted comparative effectiveness analysis of primary prevention ICDs in Medicare, racial/ethnic minority patients (nonwhite race or Hispanic ethnicity). Mortality data were obtained from the Medicare denominator file. The relationship of ICD with survival was compared between minority and white non-Hispanic patients. Our analysis included 852 minority patients, 426 ICD and 426 matched non-ICD patients, and 2070 white non-Hispanic patients (1035 ICD and 1035 matched non-ICD patients). Median follow-up was 3.1 years. Median age was 73 years, and median ejection fraction was 23%. Adjusted 3-year mortality rates for minority ICD and non-ICD patients were 44.9% (95% confidence interval [CI], 44.2%-45.7%) and 54.3% (95% CI, 53.4%-55.1%), respectively (adjusted hazard ratio, 0.79; 95% CI, 0.63-0.98; P=0.034). White non-Hispanic patients receiving an ICD had lower adjusted 3-year mortality rates of 47.8% (95% CI, 47.3%-48.3%) compared with 57.3% (95% CI, 56.8%-57.9%) for those with no ICD (adjusted hazard ratio, 0.75; 95% CI, 0.67%-0.83%; P<0.0001). There was no significant interaction between race/ethnicity and lower mortality risk with ICD (P=0.70).


CONCLUSIONS
Primary prevention ICDs are associated with lower mortality in nonwhite and Hispanic patients, similar to that seen in white, non-Hispanic patients. These data support a similar approach to ICD patient selection, regardless of race or ethnicity.
Three-dimensional and two-dimensional quantitative coronary angiography, and their prediction of reduced fractional flow reserve.

AIMS
We investigated whether three-dimensional (3D) and two-dimensional quantitative coronary angiography (2D-QCA) measurements differed in their accuracy in predicting reduced fractional flow reserve (FFR), and how this varied with stenosis severity and the FFR cut-off used.


METHODS AND RESULTS
Three-dimensional and 2D-QCA were compared in their measurements of minimum luminal area (MLA), percentage area stenosis, lesion length, minimum luminal diameter (MLD) and percentage diameter stenosis, and in their prediction of functionally significant FFR. In total, 63 target lesions were interrogated in 63 patients undergoing elective percutaneous coronary intervention. Of all measurements of lesion severity obtained by 3D-QCA, MLA best correlated with FFR (R = 0.63, P < 0.001), and was the most accurate predictor of FFR < 0.75 (C statistic 0.86, P < 0.001). Of 2D-QCA measurements, MLD correlated best with FFR (R = 0.58, P < 0.001), and best predicted FFR < 0.75 (C statistic 0.80, P < 0.001). Overall, 3D-QCA showed a non-significant trend towards more accurate prediction of FFR than 2D-QCA, especially in intermediate lesions. The relationship between FFR and apparent stenosis severity was found to be curvilinear. Both 3D- and 2D-QCA were less accurate in intermediate lesions, and in predicting FFR ≤ 0.80 than in predicting FFR <0.75.


CONCLUSIONS
The accuracy of QCA in predicting functionally significant FFR is limited and is dependent on FFR cut-off used and lesion severity. Where FFR is not available or contraindicated, 3D-QCA may assist in the evaluation of coronary lesions of intermediate severity.
LSP-Nucleus Elastic Scattering Cross Sections

We calculate LSP-nucleus elastic scattering cross sections using some representative input in the restricted SUSY parameter space. The coherent matrix elements are computed throughout the periodic table while the spin matrix elements for the proposed $^{207}Pb$ target which has a rather simple nuclear structure. The results are compared to those given from other cold dark matter detection targets.
Canine leptospirosis - a seroprevalence study from Kerala, India.

Aim: To study the seroprevalence of leptospirosis in dogs in Kerala and to identify the most prevalent serovar. Materials and Methods: A total of 205 sera collected from dogs were screened for the presence of antibodies against leptospirosis by Microscopic Agglutination Test (MAT). Results: A seroprevalence rate of 71.12 per cent was observed. Leptospira interrogans serovar Autumnalis was found to be the most prevalent serovar followed by Australis, Pomona, Canicola, Pyrogenes, Icterohaemorrhagiae, Javanica and Patoc. Conclusions: incorporation of these in the vaccines because the immunity against leptospirosis is serovar specific.
Antonio Serra: A Neglected Herald of the Acquisitive System

Abstract. The spirit of capitalism arose not from a change in religion, as Max Weber claims, but from a break in the philosophic tradition that was initiated by Machiavelli, whose economic consequences were spelled out by the Neapolitan Antonio Serra in a path breaking treatise of 1613. Serra called for an active government promoting manufacturing enterprises that would enjoy ever advancing technology and indefinite declines in unit costs. A newly-structured market economy would guarantee an ever-growing consumer basket in an acquisitive system centered in self advantage, national and individual, pursued in independence of traditional moral restraints on avarice. Writing in jail, Serra advances his new and anti-scholastic ideas with great discretion for fear of persecution by political and ecclesiastical authorities who were, at the time, against innovation of all kinds.
Flying objects detection from a single moving camera

We propose an approach to detect flying objects such as UAVs and aircrafts when they occupy a small portion of the field of view, possibly moving against complex backgrounds, and are filmed by a camera that itself moves.
Concurrency Control in Distributed Database Systems

Concurrency control is necessary and important in any multiusers, especially distributed database systems. In the paper we have briefly discussed the questions about concurrency control in distributed database systems, its eritieron of correctness, algorithms and techniques, and some questions related to its implementation such as deadloek, locks in relational database, robustness and so on.
Fuzzy Delay Compensation Control for T-S Fuzzy Systems Over Network

This paper is concerned with the network delay compensation problem for nonlinear networked control systems (NCSs). By taking full advantage of the characteristics of the packet-based transmission in NCSs, new network delay compensation approaches are proposed to actively compensate the network communication delay under the fuzzy control framework. The nonlinear plant is represented by a Takagi-Sugeno fuzzy model, and the predictive control input packets are constructed based on parallel distributed compensation technique. Both state and output feedback fuzzy delay compensation controllers are designed. Finally, two examples are provided to illustrate the effectiveness and applicability of the developed techniques.
Relative Analysis of Hierarchical Routing in Wireless Sensor Networks Using Cuckoo Search

Wireless sensor networks are those networks which are composed by the collection of very small devices mainly named as nodes. These nodes are integrated with small battery life which is very hard or impossible to replace or reinstate. For the sensing, gathering and processing capabilities, the usage of battery is must. Therefore, the battery life of Wireless Sensor Networks should be as large as possible in order to sense the information around it or in which the nodes are placed. The concept of hierarchical routing is mainly highlighted in this paper, in which the nodes work in a hierarchical manner by the formation of Cluster Head within a Cluster. These formed Cluster Heads then transfer the data or information in the form of packets from one cluster to another. In this work, the protocol used for the simulation is Low Energy adaptive Clustering Hierarchy which is one of the most efficient protocol. The nodes are of homogeneous in nature. The simulator used is MATLAB along with Cuckoo Search Algorithm. The Simulation results have been taken out showing the effectiveness of protocol with Cuckoo Search. Keywords— Wireless Sensor Network (WSN), Low Energy adaptive Clustering Hierarchy (LEACH), Cuckoo Search, Cluster Head (CH), Base Station (BS).
Tranylcypromine versus venlafaxine plus mirtazapine following three failed antidepressant medication trials for depression: a STAR*D report.

OBJECTIVE
The purpose of this study was to compare the effectiveness and tolerability of tranylcypromine and combination treatment with extended-release venlafaxine and mirtazapine in patients with treatment-resistant major depression whose current depressive episode had not responded adequately to treatment in three prior prospective medication trials.


METHOD
Adult outpatients with nonpsychotic major depressive disorder who had not achieved remission or had withdrawn from treatment because of intolerance in three previous prospective medication trials were randomly assigned to receive open-label treatment with either tranylcypromine (N=58) or extended-release venlafaxine plus mirtazapine (N=51). The primary outcome measure was whether patients achieved remission, which was defined as a score < or =7 at exit on the 17-item Hamilton Depression Rating Scale (HAM-D). The HAM-D was administered by telephone by raters to whom treatment was masked.


RESULTS
Remission rates were not significantly different between the two treatment groups (6.9% for the tranylcypromine group and 13.7% for the venlafaxine plus mirtazapine group). The mean daily dose at exit for tranylcypromine was 36.9 mg (SD=18.5); for venlafaxine, 210.3 mg (SD=95.2); and for mirtazapine, 35.7 mg (SD=17.6). Tranylcypromine was associated with significantly less symptom reduction and greater attrition due to intolerance.


CONCLUSIONS
Remission rates were modest for both the tranylcypromine group and the extended-release venlafaxine plus mirtazapine group, and the rates were not statistically different between groups. The lower side effect burden, lack of dietary restrictions, and ease of use of venlafaxine and mirtazapine suggest that this combination may be preferred over tranylcypromine for patients with highly treatment-resistant depression who have not benefited adequately from several prior treatments.