LLukas22/scidocs huggingface dataset:
Viral stimuli trigger exaggerated thymic stromal lymphopoietin expression by chronic obstructive pulmonary disease epithelium: role of endosomal TLR3 and cytosolic RIG-I-like helicases.

BACKGROUND
Rhinovirus (RV)-induced chronic obstructive pulmonary disease (COPD) exacerbations exhibit TH(2)-like inflammation. We hypothesized that RV-infected bronchial epithelial cells (BEC) overproduce TH(2)-switching hub cytokine, thymic stromal lymphopoietin (TSLP) in COPD.


METHODS
Primary BEC from healthy (HBEC) and from COPD donors (COPD-BEC) were grown in 12-well plates, infected with RV16 (0.5-5 MOI) or stimulated with agonists for either toll-like receptor (TLR) 3 (dsRNA, 0.1-10 μg/ml) or RIG-I-like helicases (dsRNA-LyoVec, 0.1-10 μg/ml). Cytokine mRNA and protein were determined (RTqPCR; ELISA).


RESULTS
dsRNA dose-dependently evoked cytokine gene overproduction of TSLP, CXCL8 and TNF-α in COPD-BEC compared to HBEC. This was confirmed using RV16 infection. IFN-β induction did not differ between COPD-BEC and HBEC. Endosomal TLR3 inhibition by chloroquine dose-dependently inhibited dsRNA-induced TSLP generation and reduced generation of CXCL8, TNF-α, and IFN-β. Stimulation of cytosolic viral sensors (RIG-I-like helicases) with dsRNA-LyoVec increased production of CXCL8, TNF-α, and IFN-β, but not TSLP.


CONCLUSIONS
Endosomal TLR3-stimulation, by dsRNA or RV16, induces overproduction of TSLP in COPD-BEC. dsRNA- and RV-induced overproduction of TNF-α and CXCL8 involves endosomal TLR3 and cytosolic RIG-I-like helicases and so does the generation of IFN-β in COPD-BEC. RV16 and dsRNA-induced epithelial TSLP may contribute to pathogenic effects at exacerbations and development of COPD.
Simple solutions of relativistic hydrodynamics for systems with ellipsoidal symmetry

Simple, self-similar, analytic solutions of (1+3)-dimensional relativistic hydrodynamics are presented for ellipsoidally symmetric finite fireballs corresponding to non-central collisions of heavy ions at relativistic bombarding energies. The hydrodynamical solutions are obtained for a new, general family of equations of state with the possibility of describing phase transitions.
PEOPLE'S PERCEPTION ON HOUSEHOLD SOLID WASTE MANAGEMENT IN OJO LOCAL GOVERNMENT AREA IN NIGERIA

The current work examined the structure of household waste management system, collection and disposal within the context of a wider research on integrated solid waste management in households. A sample of 30 households from eleven selected residential areas with a focus group of 60 respondents in Ojo Local Government Area, Lagos State, Nigeria was used. The selected residential areas were divided into high, middle and low socio-economic strata. The research examined a range of environmental behaviours, attitude and perception of respondents on household solid waste management. The results established waste management behaviours among the respondents on solid waste management system, services, patronage of services and cost recovery methods. Public opinion and perception on solid waste management system is characterized with irregularity and inefficient collection system; with poor monitoring of the private waste service providers by the local authority. Willingness to pay for waste management services provided by the private service providers, the Private Sector Participation operators is higher among the middle and high income socio-economic groups than in the low income group. However, with the application of sustainable environmental education greater success ratio could be achieved. Level of patronage of solid waste management services is high across the three socio-economic groups but patronage is shared among the two operating service providers (formal and informal). The Private Sector Participation has the highest patronage level with 64.6% severity index while the informal sector (Cart pushers) have only 48.7% severity index both percentages translate to the agreed and neutral perception opinion ranges respectively. The paper advocates for improved solid waste management system through proper monitoring of the services of the Private Sector Participation operators by the Local Government Area for improved service efficiency. Finally the research suggests appropriate lines of action on sustainability of a private sector driven solid waste management scheme in the Local Government Area and in Lagos State in general.
Visual-Inertial Combined Odometry System for Aerial Vehicles

The requirement to operate aircraft in GPS-denied environments can be met by using visual odometry. Aiming at a full-scale aircraft equipped with a high-accuracy inertial navigation system (INS), the proposed method combines vision and the INS for odometry estimation. With such an INS, the aircraft orientation is accurate with low drift, but it contains high-frequency noise that can affect the vehicle motion estimation, causing position estimation to drift. Our method takes the INS orientation as input and estimates translation. During motion estimation, the method virtually rotates the camera by reparametrizing features with their depth direction perpendicular to the ground. This partially eliminates error accumulation in motion estimation caused by the INS high-frequency noise, resulting in a slow drift. We experiment on two hardware configurations in the acquisition of depth for the visual features: 1) the height of the aircraft above the ground is measured by an altimeter assuming that the imaged ground is a local planar patch, and 2) the depth map of the ground is registered with a two-dimensional laser in a push-broom configuration. The method is tested with data collected from a full-scale helicopter. The accumulative flying distance for the overall tests is approximately 78 km. We observe slightly better accuracy with the push-broom laser than the altimeter. C © 2015 Wiley Periodicals, Inc.
The relationship between ERP system and supply chain management performance in Malaysian manufacturing companies

Purpose – This research aims to improve supply chain management performance through the successful usage of ERP system. This can be through investigating the relationship between enterprise resource planning (ERP) system and supply chain management (SCM) performance in the context of Malaysian manufacturing companies that use ERP system. Design/methodology/approach – The questionnaire survey was posted to the Malaysian manufacturing companies that are using ERP system in order to investigate the relationship between ERP system and SCM performance. The respondents of this study were the MIS or IT executives. A total of 80 usable responses were received and used in the analysis. Findings – The findings of this research indicated that there is a positive and significant relationship between ERP system i.e. (integration, material management, production planning, and controlling), and SCM performance. The workflow management, however, does not have a significant relationship with SCM performance. The findings of this study imply that the successful implementation and the effective usage of ERP system can contribute toward enhancing supply chain management performance in many ways such as, integration of internal business processes, enhancement of information flow among different departments inside the company, improvement of the company’s relationships and collaboration with outsourcing suppliers, customers, and supply chain partners. Research limitations/implications – This research focuses only on post-implementation of ERP system life cycle, where ERP system passes through three implementation stages of system life cycle and that includes pre-implantation stage, implementation stage, and finally post-implementation stage. Two or three stages of ERP system life cycle could be investigated simultaneously. Practical implications – There should be many success records in ERP system and this is to prove to companies that ERP systems can contribute toward improving their overall business performance. Therefore, this research encourages companies to adopt ERP systems and then contribute to technology diffusion. The finding of this study supports this justification and records a new success of ERP systems in Malaysian manufacturing companies. Originality/value – The results of this study will enable companies to achieve optimum usage of ERP system after the implementation stage and help to avoid system failure and achieve better SCM performance. The study contributes toward technology diffusion between companies through reducing the likelihood of ERP systems failure, and therefore introduces ERP systems to other manufacturing companies in Malaysia.
Toponym matching through deep neural networks

Toponym matching, i.e. pairing strings that represent the same real-world location, is a fundamental problemfor several practical applications. The current state-of-the-art relies on string similarity metrics, either specifically developed for matching place names or integrated within methods that combine multiple metrics. However, these methods all rely on common sub-strings in order to establish similarity, and they do not effectively capture the character replacements involved in toponym changes due to transliterations or to changes in language and culture over time. In this article, we present a novel matching approach, leveraging a deep neural network to classify pairs of toponyms as either matching or nonmatching. The proposed network architecture uses recurrent nodes to build representations from the sequences of bytes that correspond to the strings that are to be matched. These representations are then combined and passed to feed-forward nodes, finally leading to a classification decision. We present the results of a wide-ranging evaluation on the performance of the proposed method, using a large dataset collected from the GeoNames gazetteer. These results show that the proposed method can significantly outperform individual similarity metrics from previous studies, as well as previous methods based on supervised machine learning for combining multiple metrics. ARTICLE HISTORY Received 16 May 2017 Accepted 5 October 2017
Prognostic significance of atrial fibrillation in advanced heart failure. A study of 390 patients.

BACKGROUND
Atrial fibrillation is common in advanced heart failure, but its prognostic significance is controversial.


METHODS AND RESULTS
We evaluated the relation of atrial rhythm to overall survival and sudden death in 390 consecutive advanced heart failure patients. Etiology of heart failure was coronary artery disease in 177 patients (45%) and nonischemic cardiomyopathy or valvular heart disease in 213 patients (55%). Mean left ventricular ejection fraction was 0.19 +/- 0.07. Seventy-five patients (19%) had paroxysmal (26 patients) or chronic (49 patients) atrial fibrillation. Compared with patients with sinus rhythm, patients with atrial fibrillation did not differ in etiology of heart failure, mean pulmonary capillary wedge pressure on therapy, or embolic events but were more likely to be receiving warfarin and antiarrhythmic drugs and had a slightly higher left ventricular ejection fraction. After a mean follow-up of 236 +/- 303 days, 98 patients died: 56 (57%) died suddenly, and 36 (37%) died of progressive heart failure. Actuarial 1-year overall survival was 68%, and sudden death-free survival was 79%. Actuarial survival was significantly worse for atrial fibrillation than for sinus rhythm patients (52% versus 71%, p = 0.0013). Similarly, sudden death-free survival was significantly worse for atrial fibrillation than for sinus rhythm patients (69% versus 82%, p = 0.0013). By Cox proportional hazards model, pulmonary capillary wedge pressure on therapy, left ventricular ejection fraction, coronary artery disease, and atrial fibrillation were independent risk factors for total mortality and sudden death. For patients who had pulmonary capillary wedge pressure of less than 16 mm Hg on therapy, atrial fibrillation was associated with poorer 1-year survival (44% versus 83%, p = 0.00001); however, in the high pulmonary capillary wedge pressure group, atrial fibrillation did not confer an increased risk (58% versus 57%).


CONCLUSIONS
Atrial fibrillation is a marker for increased risk of death, especially in heart failure patients who have lower filling pressures on vasodilator and diuretic therapy. Whether aggressive attempts to maintain sinus rhythm will reduce this risk is unknown.
Executive Functioning in Alcoholics Following an mHealth Cognitive Stimulation Program: Randomized Controlled Trial

BACKGROUND
The consequences of alcohol dependence are severe and may range from physical disease to neuropsychological deficits in several cognitive domains. Alcohol abuse has also been related to brain dysfunction specifically in the prefrontal cortex. Conventional neuropsychological interventions (paper-and-pencil cognitive stimulation training) have a positive effect but are time-consuming, costly, and not motivating for patients.


OBJECTIVE
Our goal was to test the cognitive effects of a novel approach to neuropsychological intervention, using mobile technology and serious games, on patients with alcohol dependence.


METHODS
The trial design consisted of a two-arm study assessing the cognitive outcomes of neuropsychological intervention with mobile serious games (mHealth) versus control (treatment-as-usual with no neuropsychological intervention) in patients undergoing treatment for alcohol dependence syndrome. Sixty-eight patients were recruited from an alcohol-rehab clinic and randomly assigned to the mHealth (n=33) or control condition (n=35). The intervention on the experimental group consisted of a therapist-assisted cognitive stimulation therapy for 4 weeks on a 2-3 days/week basis.


RESULTS
Fourteen patients dropped out of the study. The results of the neuropsychological assessments with the remaining 54 patients showed an overall increase (P<.05) of general cognitive abilities, mental flexibility, psychomotor processing speed, and attentional ability in both experimental (n=26) and control groups (n=28). However, there was a more pronounced improvement (P=.01) specifically in frontal lobe functions from baseline (mean 13.89, SE 0.58) to follow-up (mean 15.50, SE 0.46) in the experimental group but not in the control group.


CONCLUSIONS
The overall increase in general cognitive function for both experimental and control groups supports the beneficial role of existing alcohol treatment protocols aimed at minimizing withdrawal symptoms, but the differential improvements observed in frontal lobe functioning supports the use of mobile serious games for neuropsychological stimulation to overcome executive dysfunction in patients with alcohol dependence. This trial was negative on two neuropsychological/cognitive tests, and positive on one.


TRIAL REGISTRATION
ClinicalTrials.gov NCT01942954; http://www.clinicaltrials.gov/ct2/show/NCT01942954.
Abdominal radiograph pearls and pitfalls for the emergency department radiologist: a pictorial review

Abdominal plain films are often the first imaging examination performed on a patient with abdominal pain in the emergency department. Radiograph findings can help guide clinical management and the need for advanced imaging. A pictorial review of a range of abdominal radiograph findings is presented, including bowel gas patterns, abdominal organ evaluation, pathologic gas, calcifications, implanted devices, and foreign bodies.
MUSIC: Middleware Support for Self-Adaptation in Ubiquitous and Service-Oriented Environments

Self-adaptive component-based architectures facilitate the building of systems capable of dynamically adapting to varying execution context. Such a dynamic adaptation is particularly relevant in the domain of ubiquitous computing, where numerous and unexpected changes of the execution context prevail. In this paper, we introduce an extension of the MUSIC component-based planning framework that optimizes the overall utility of applications when such changes occur. In particular, we focus on changes in the service provider landscape in order to plug in interchangeably components and services providing the functionalities defined by the component framework. The dynamic adaptations are operated automatically for optimizing the application utility in a given execution context. Our resulting planning framework is described and validated on a motivating scenario of the MUSIC project.
The impact of health information on the internet on the physician-patient relationship: patient perceptions.

BACKGROUND
Use of the Internet for health information continues to grow rapidly, but its impact on health care is unclear. Concerns include whether patients' access to large volumes of information will improve their health; whether the variable quality of the information will have a deleterious effect; the effect on health disparities; and whether the physician-patient relationship will be improved as patients become more equal partners, or be damaged if physicians have difficulty adjusting to a new role.


METHODS
Telephone survey of nationally representative sample of the American public, with oversample of people in poor health.


RESULTS
Of the 3209 respondents, 31% had looked for health information on the Internet in the past 12 months, 16% had found health information relevant to themselves and 8% had taken information from the Internet to their physician. Looking for information on the Internet showed a strong digital divide; however, once information had been looked for, socioeconomic factors did not predict other outcomes. Most (71%) people who took information to the physician wanted the physician's opinion, rather than a specific intervention. The effect of taking information to the physician on the physician-patient relationship was likely to be positive as long as the physician had adequate communication skills, and did not appear challenged by the patient bringing in information.


CONCLUSIONS
For health information on the Internet to achieve its potential as a force for equity and patient well-being, actions are required to overcome the digital divide; assist the public in developing searching and appraisal skills; and ensure physicians have adequate communication skills.
A randomized, wait-list controlled clinical trial: the effect of a mindfulness meditation-based stress reduction program on mood and symptoms of stress in cancer outpatients.

OBJECTIVE
The objective of this study was to assess the effects of participation in a mindfulness meditation-based stress reduction program on mood disturbance and symptoms of stress in cancer outpatients.


METHODS
A randomized, wait-list controlled design was used. A convenience sample of eligible cancer patients enrolled after giving informed consent and were randomly assigned to either an immediate treatment condition or a wait-list control condition. Patients completed the Profile of Mood States and the Symptoms of Stress Inventory both before and after the intervention. The intervention consisted of a weekly meditation group lasting 1.5 hours for 7 weeks plus home meditation practice.


RESULTS
Ninety patients (mean age, 51 years) completed the study. The group was heterogeneous in type and stage of cancer. Patients' mean preintervention scores on dependent measures were equivalent between groups. After the intervention, patients in the treatment group had significantly lower scores on Total Mood Disturbance and subscales of Depression, Anxiety, Anger, and Confusion and more Vigor than control subjects. The treatment group also had fewer overall Symptoms of Stress; fewer Cardiopulmonary and Gastrointestinal symptoms; less Emotional Irritability, Depression, and Cognitive Disorganization; and fewer Habitual Patterns of stress. Overall reduction in Total Mood Disturbance was 65%, with a 31% reduction in Symptoms of Stress.


CONCLUSIONS
This program was effective in decreasing mood disturbance and stress symptoms in both male and female patients with a wide variety of cancer diagnoses, stages of illness, and ages. cancer, stress, mood, intervention, mindfulness.
Enterprise Information Portals and Enterprise Knowledge Portal

"Enterprise Information Portals are applications that enable companies to unlock internally and externally stored information, and provide users a single gateway to personalized information needed to make informed business decisions. " They are: ". . . an amalgamation of software applications that consolidate, manage, analyze and distribute information across and outside of an enterprise (including Business Intelligence, Content Management, Data Warehouse & Mart and Data Management applications.)"
Age-related changes in Serum Growth Hormone, Insulin-like Growth Factor-1 and Somatostatin in System Lupus Erythematosus

BACKGROUND
Systemic lupus erythematosus is an age- and gender-associated autoimmune disorder. Previous studies suggested that defects in the hypothalamic/pituitary axis contributed to systemic lupus erythematosus disease progression which could also involve growth hormone, insulin-like growth factor-1 and somatostatin function. This study was designed to compare basal serum growth hormone, insulin-like growth factor-1 and somatostatin levels in female systemic lupus erythematosus patients to a group of normal female subjects.


METHODS
Basal serum growth hormone, insulin-like growth factor-1 and somatostatin levels were measured by standard radioimmunoassay.


RESULTS
Serum growth hormone levels failed to correlate with age (r2 = 3.03) in the entire group of normal subjects (i.e. 20 - 80 years). In contrast, serum insulin-like growth factor-1 levels were inversely correlated with age (adjusted r2 = 0.092). Of note, serum growth hormone was positively correlated with age (adjusted r2 = 0.269) in the 20 - 46 year range which overlapped with the age range of patients in the systemic lupus erythematosus group. In that regard, serum growth hormone levels were not significantly higher compared to either the entire group of normal subjects (20 - 80 yrs) or to normal subjects age-matched to the systemic lupus erythematosus patients. Serum insulin-like growth factor-1 levels were significantly elevated (p < 0.001) in systemic lupus erythematosus patients, but only when compared to the entire group of normal subjects. Serum somatostatin levels differed from normal subjects only in older (i.e. >55 yrs) systemic lupus erythematosus patients.


CONCLUSIONS
These results indicated that systemic lupus erythematosus was not characterized by a modulation of the growth hormone/insulin-like growth factor-1 paracrine axis when serum samples from systemic lupus erythematosus patients were compared to age- matched normal female subjects. These results in systemic lupus erythematosus differ from those previously reported in other musculoskeletal disorders such as rheumatoid arthritis, osteoarthritis, fibromyalgia, diffuse idiopathic skeletal hyperostosis and hypermobility syndrome where significantly higher serum growth hormone levels were found. Somatostatin levels in elderly systemic lupus erythematosus patients may provide a clinical marker of disease activity in these patients.