LLukas22/scidocs huggingface dataset:
A Simulation Framework for Sensor Networks in J-Sim

Sensor networks have gained considerable importance and attention in the past few years. Hence, an inevitable need for developing simulation frameworks for sensor networks in existing network simulators arises. In this paper, we describe our work in incorporating wireless sensor networks simulation in J-Sim. We have built a simulation framework for sensor networks that builds upon the autonomous component architecture (ACA) and the extensible internetworking framework (INET) of J-Sim. The paper shows how each layer in the protocol stack of a sensor node can be implemented as a component and how ports and contracts enable different layers (components) to interact with each other in the initiator-reactor mechanism that is a fundamental concept of J-Sim.
Spray Cooling of High Aspect Ratio Open Microchannels

Direct spraying of dielectric liquids has been shown to be an effective method of cooling high power electronics. Recent studies have illustrated that even higher heat transfer can be obtained by adding extended structures, particularly straight fins, to the heated surface. In the current work, spray cooling of high aspect ratio open microchannels was explored, which substantially increases the total surface area allowing more residence time for the incoming liquid to be heated by the wall. Five such heat sinks were EDM wire machined and their thermal performance was investigated. These 1.41times1.41 cm2 heat sinks featured a channel width of 360 mum; a fin width of 500 mum; and fin lengths of 0.25 mm, 0.50 mm, 1.0 mm, 3.0 mm, and 5.0 mm. The five enhanced surfaces and a flat surface with the same projected area were sprayed with a full cone nozzle using PF-5060 at 30degC and nozzle pressure differences from 1.36-4.08 atm (20-60 psig). In all cases, the enhanced surfaces improved thermal performance compared to the flat surface. Longer fins were found to outperform shorter ones in the single-phase regime. Adding fins also resulted in two-phase effects (and higher heat transfer) at lower wall temperatures than the flat surface. The two-phase regime appeared to be marked by a balance between added area, changing flow flux, channeling, and added conduction resistance. Spray efficiency calculations indicated that a much larger percentage of the liquid sprayed onto the enhanced surface evaporated than with the flat surface. Fin lengths between 1 and 3 mm appeared to be optimum for heat fluxes as high as 124 W/cm and the range of conditions studied
Video-games used in a group setting is feasible and effective to improve indicators of physical activity in individuals with chronic stroke: a randomized controlled trial.

OBJECTIVES
To investigate the feasibility of using video-games in a group setting and to compare the effectiveness of video-games as a group intervention to a traditional group intervention for improving physical activity in individuals with chronic stroke.


DESIGN
A single-blind randomized controlled trial with evaluations pre and post a 3-month intervention, and at 3-month follow-up. Compliance (session attendance), satisfaction and adverse effects were feasibility measures. Grip strength and gait speed were measures of physical activity. Hip accelerometers quantified steps/day and the Action Research Arm Test assessed the functional ability of the upper extremity.


RESULTS
Forty-seven community-dwelling individuals with chronic stroke (29-78 years) were randomly allocated to receive video-game (N=24) or traditional therapy (N=23) in a group setting. There was high treatment compliance for both interventions (video-games-78%, traditional therapy-66%), but satisfaction was rated higher for the video-game (93%) than the traditional therapy (71%) (χ(2)=4.98, P=0.026). Adverse effects were not reported in either group. Significant improvements were demonstrated in both groups for gait speed (F=3.9, P=0.02), grip strength of the weaker (F=6.67, P=0.002) and stronger hands (F=7.5, P=0.001). Daily steps and functional ability of the weaker hand did not increase in either group.


CONCLUSIONS
Using video-games in a small group setting is feasible, safe and satisfying. Video-games improve indicators of physical activity of individuals with chronic stroke.
A recommendation mechanism for contextualized mobile advertising

Mobile advertising complements the Internet and interactive television advertising and makes it possible for advertisers to create tailormade campaigns targeting users according to where they are, their needs of the moment and the devices they are using (i.e. contextualized mobile advertising). Therefore, it is necessary that a fully personalized mobile advertising infrastructure be made. In this paper, we present such a personalized contextualized mobile advertising infrastructure for the advertisement of commercial/non-commercial activities. We name this infrastructure MALCR, in which the primary ingredient is a recommendation mechanism that is supported by the following concepts: (1) minimize users’ inputs (a typical interaction metaphor for mobile devices) for implicit browsing behaviors to be best utilized; (2) implicit browsing behaviors are then analyzed with a view to understanding the users’ interests in the values of features of advertisements; (3) having understood the users’ interests, Mobile Ads relevant to a designated location are subsequently scored and ranked; (4) Top-N scored advertisements are recommended. The recommendation mechanism is novel in its combination of two-level Neural Network learning, Neural Network sensitivity analysis, and attribute-based filtering. This recommendation mechanism is also justified (by thorough evaluations) to show its ability in furnishing effective personalized contextualized mobile advertising. q 2003 Elsevier Science Ltd. All rights reserved.
Pharmacokinetic, pharmacodynamic and biomarker evaluation of transforming growth factor-β receptor I kinase inhibitor, galunisertib, in phase 1 study in patients with advanced cancer

Purpose Transforming growth factor-beta (TGF-β) signaling plays a key role in epithelial-mesenchymal transition (EMT) of tumors, including malignant glioma. Small molecule inhibitors (SMI) blocking TGF-β signaling reverse EMT and arrest tumor progression. Several SMIs were developed, but currently only LY2157299 monohydrate (galunisertib) was advanced to clinical investigation. Design The first-in-human dose study had three parts (Part A, dose escalation, n = 39; Part B, safety combination with lomustine, n = 26; Part C, relative bioavailability study, n = 14). Results A preclinical pharmacokinetic/pharmacodynamic (PK/PD) model predicted a therapeutic window up to 300 mg/day and was confirmed in Part A after continuous PK/PD. PK was not affected by co-medications such as enzyme-inducing anti-epileptic drugs or proton pump inhibitors. Changes in pSMAD2 levels in peripheral blood mononuclear cells were associated with exposure indicating target-related pharmacological activity of galunisertib. Twelve (12/79; 15 %) patients with refractory/relapsed malignant glioma had durable stable disease (SD) for 6 or more cycles, partial responses (PR), or complete responses (CR). These patients with clinical benefit had high plasma baseline levels of MDC/CCL22 and low protein expression of pSMAD2 in their tumors. Of the 5 patients with IDH1/2 mutation, 4 patients had a clinical benefit as defined by CR/PR and SD ≥6 cycles. Galunisertib had a favorable toxicity profile and no cardiac adverse events. Conclusion Based on the PK, PD, and biomarker evaluations, the intermittent administration of galunisertib at 300 mg/day is safe for future clinical investigation.
Impact of facebook addiction on narcissistic behavior and self-esteem among students.

OBJECTIVE
To investigate the relationship between Facebook addiction, narcissism and self-esteem and to see if gender played any role in this equation.


METHODS
The correlational study was conducted from February to March 2013 at the Department of Psychology, University of Sargodha, Punjab, Pakistan. Using convenient sampling, two equal groups of male and female students were enrolled from different departments of the university. Bergen Facebook Addiction Scale, Hypersensitive Narcissism Scale and Rosenberg's Self-esteem Scale were used for evaluation. SPSS 17 was used for statistical analysis.


RESULTS
Of the 200 subjects in the study, 100(50%) each were males and females. Facebook addiction was positively correlated with narcissism(r=0.20; p<0.05) and negatively with self-esteem(r=-0.18; p<0.05). Relationship between narcissism and self-esteem was non-significant(r=0.05; p>0.05). Facebook addiction was a significant predictor of narcissistic behaviour (b=0.202; p<0.001) and low self-esteem (b=-0.18; p<0.001). There were no significant gender differences in the three variables (p>0.05 each).


CONCLUSIONS
Facebook addiction was a significant predictor of narcissistic behaviour and low levels of self-esteem among students.
Self-ensembling for visual domain adaptation

This paper explores the use of self-ensembling for visual domain adaptation problems. Our technique is derived from the mean teacher variant [29] of temporal ensembling [14], a technique that achieved state of the art results in the area of semi-supervised learning. We introduce a number of modifications to their approach for challenging domain adaptation scenarios and evaluate its effectiveness. Our approach achieves state of the art results in a variety of benchmarks, including our winning entry in the VISDA-2017 visual domain adaptation challenge. In small image benchmarks, our algorithm not only outperforms prior art, but can also achieve accuracy that is close to that of a classifier trained in a supervised fashion.
Fault Monitoring of Wind Turbine Generator Brushes : A Data-Mining Approach

Components of wind turbines are subjected to asymmetric loads caused by variable wind conditions. Carbon brushes are critical components of the wind turbine generator. Adequately maintaining and detecting abnormalities in the carbon brushes early is essential for proper turbine performance. In this paper, data-mining algorithms are applied for early prediction of carbon brush faults. Predicting generator brush faults early enables timely maintenance or replacement of brushes. The results discussed in this paper are based on analyzing generator brush faults that occurred on 27 wind turbines. The datasets used to analyze faults were collected from the supervisory control and data acquisition (SCADA) systems installed at the wind turbines. Twenty-four data-mining models are constructed to predict faults up to 12 h before the actual fault occurs. To increase the prediction accuracy of the models discussed, a data balancing approach is used. Four data-mining algorithms were studied to evaluate the quality of the models for predicting generator brush faults. Among the selected data-mining algorithms, the boosting tree algorithm provided the best prediction results. Research limitations attributed to the available datasets are discussed. [DOI: 10.1115/1.4005624]
Running injury and stride time variability over a prolonged run.

Locomotor variability is inherent to movement and, in healthy systems, contains a predictable structure. In this study, detrended fluctuation analysis (DFA) was used to quantify the structure of variability in locomotion. Using DFA, long-range correlations (α) are calculated in over ground running and the influence of injury and fatigue on α is examined. An accelerometer was mounted to the tibia of 18 runners (9 with a history of injury) to quantify stride time. Participants ran at their preferred 5k pace±5% on an indoor track to fatigue. The complete time series data were divided into three consecutive intervals (beginning, middle, and end). Mean, standard deviation (SD), coefficient of variation (CV) and α of stride times were calculated for each interval. Averages for all variables were calculated per group for statistical analysis. No significant interval, group or interval×group effects were found for mean, SD or CV of stride time. A significant linear trend in α for interval occurred with a reduction in α over the course of the run (p=0.01) indicating that over the run, stride times of runners became more unpredictable. This was likely due to movement errors associated with fatigue necessitating frequent corrections. The injured group exhibited lower α (M=0.79, CI(95)=0.70, 0.88) than the non-injured group (p=0.01) (M=0.96, CI(95)=0.88, 1.05); a reduction hypothesized to be associated with altered complexity. Overall, these findings suggest injury and fatigue influence neuromuscular output during running.
Nuclear PARP-1 protein overexpression is associated with poor overall survival in early breast cancer.

BACKGROUND
Poly(ADP-ribose)polymerase-1 (PARP-1) is a highly promising novel target in breast cancer. However, the expression of PARP-1 protein in breast cancer and its associations with outcome are yet poorly characterized.


PATIENTS AND METHODS
Quantitative expression of PARP-1 protein was assayed by a specific immunohistochemical signal intensity scanning assay in a range of normal to malignant breast lesions, including a series of patients (N = 330) with operable breast cancer to correlate with clinicopathological factors and long-term outcome.


RESULTS
PARP-1 was overexpressed in about a third of ductal carcinoma in situ and infiltrating breast carcinomas. PARP-1 protein overexpression was associated to higher tumor grade (P = 0.01), estrogen-negative tumors (P < 0.001) and triple-negative phenotype (P < 0.001). The hazard ratio (HR) for death in patients with PARP-1 overexpressing tumors was 7.24 (95% CI; 3.56-14.75). In a multivariate analysis, PARP-1 overexpression was an independent prognostic factor for both disease-free (HR 10.05; 95% CI 5.42-10.66) and overall survival (HR 1.82; 95% CI 1.32-2.52).


CONCLUSIONS
Nuclear PARP-1 is overexpressed during the malignant transformation of the breast, particularly in triple-negative tumors, and independently predicts poor prognosis in operable invasive breast cancer.
Tensegrities and Global Rigidity

A tensegrity is finite configuration of points in Ed suspended rigidly by inextendable cables and incompressable struts. Here it is explained how a stress-energy function, given by a symmetric stress matrix, can be used to create tensegrities that are globally rigid in the sense that the only configurations that satisfy the cable and strut constraints are congruent copies.
5G transport networks: the need for new technologies and standards

Mobile transport networks will play a vital role in future 5G and beyond networks. In particular, access transport networks connecting radio access with core networks are of critical importance. They will be required to support massive connectivity, super high data rates, and real-time services in a ubiquitous environment. To attain these targets, transport networks should be constructed on the basis of a variety of technologies and methods, depending on application scenarios, geographic areas, and deployment models. In this article, we present several technologies, including analog radio-over-fiber transmission, intermediate-frequency- over-fiber technology, radio-on-radio transmission, and the convergence of fiber and millimeter-wave systems, that can facilitate building such effective transport networks in many use cases. For each technology, we present the system concept, possible application cases, and demonstration results. We also discuss potential standardization and development directions so the proposed technologies can be widely used.
Low-dose of statin treatment improves cerebrovascular reactivity in patients with ischemic stroke: single photon emission computed tomography analysis.

BACKGROUND
Statins, 3-hydroxy-3-methylglutaryl-coenzymeA reductase inhibitors, have pleiotropic effects that are independent of their cholesterol-lowering activities. For example, they improve vascular endothelial function and exert anti-inflammatory effects. In large clinical trials they reduced the incidence of stroke and myocardial infarction; however, little is currently known regarding the mechanism or mechanisms underlying their clinically confirmed stroke protection.


PATIENTS AND METHODS
We assessed 10 patients who had experienced a stroke at least 6 months earlier; they received low-dose (5 mg) simvastatin. Using our triple-injection technetium 99m-ethylcysteinate dimer method, we determined their cerebral blood flow and cerebrovascular reactivity. A second assessment of at-rest cerebral blood flow and cerebrovascular reactivity was performed 4 or more months (mean 6 months) after the start of statin administration. We used acetazolamide (1 g) as the vasodilator. The region of interest was the middle cerebral artery territory on a 3-dimensional stereotaxic region of interest template.


RESULTS
Statin administration did not significantly affect the regional cerebral blood flow at rest. Before statin treatment, the patients' vasoreactivity, determined by the triple-injection technetium 99m-ethylcysteinate dimer method, demonstrated delayed, poor, or near-normal response patterns. Statin treatment improved vasoreactivity in all patients. Their mean serum total cholesterol level before statin administration was 200 mg/dL (range 187-256 mg/dL). Statin treatment significantly reduced their mean serum total cholesterol to 180 mg/dL (range 128-220 mg/dL) (P < .01).


CONCLUSIONS
The clinically confirmed stroke protection activity exerted by statins may be attributable to improved cerebrovascular reactivity.
SNPs in DNA repair or oxidative stress genes and late subcutaneous fibrosis in patients following single shot partial breast irradiation

BACKGROUND
The aim of this study was to evaluate the potential association between single nucleotide polymorphisms related response to radiotherapy injury, such as genes related to DNA repair or enzymes involved in anti-oxidative activities. The paper aims to identify marker genes able to predict an increased risk of late toxicity studying our group of patients who underwent a Single Shot 3D-CRT PBI (SSPBI) after BCS (breast conserving surgery).


METHODS
A total of 57 breast cancer patients who underwent SSPBI were genotyped for SNPs (single nucleotide polymorphisms) in XRCC1, XRCC3, GST and RAD51 by Pyrosequencing technology. Univariate analysis (ORs and 95% CI) was performed to correlate SNPs with the risk of developing ≥ G2 fibrosis or fat necrosis.


RESULTS
A higher significant risk of developing ≥ G2 fibrosis or fat necrosis in patients with: polymorphic variant GSTP1 (Ile105Val) (OR = 2.9; 95%CI, 0.88-10.14, p = 0.047).


CONCLUSIONS
The presence of some SNPs involved in DNA repair or response to oxidative stress seem to be able to predict late toxicity.


TRIAL REGISTRATION
ClinicalTrials.gov: NCT01316328.
Methods of the Water-Energy-Food Nexus

This paper focuses on a collection of methods that can be used to analyze the water-energy-food (WEF) nexus. We classify these methods as qualitative or quantitative for interdisciplinary and transdisciplinary research approaches. The methods for interdisciplinary research approaches can be used to unify a collection of related variables, visualize the research problem, evaluate the issue, and simulate the system of interest. Qualitative methods are generally used to describe the nexus in the region of interest, and include primary research methods such as Questionnaire Surveys, as well as secondary research methods such as Ontology Engineering and Integrated Maps. Quantitative methods for examining the nexus include Physical Models, Benefit-Cost Analysis (BCA), OPEN ACCESS
Severe Fusobacteria infections (Lemierre syndrome) in two boys

Abscess formation is a rare cause of febrile illness in childhood but always has to be considered in such clinical presentations. Belonging to the resident flora of the oropharyngeal region, Fusobacteria are known to cause local infections; from here they may extend to other sites via the bloodstream or are aspirated into the lung (Lemierre disease). We report on two boys with Lemierre disease due to infection by Fusobacteria in monoculture causing two different clinical phenotypes. Case 1 presented with a large subphrenic abscess and pneumonic infiltration of the right middle lobe. Primary focus of infection was periodontal disease. Case 2 presented with a life-threatening septicaemia due to a retropharyngeal abscess and perforated otitis media followed by osteomyelitis of the atlas and thrombosis of the left sigmoid sinus and internal jugular vein. Conclusion: Fusobacteria should be considered in any abscess formation in children. A thorough examination of the oropharyngeal region as a possible site of primary manifestation is mandatory.
Scheduling and Priority Mapping for Static Real-Time Middleware

This paperpresents a middleware real-time scheduling technique for static,distributed, real-time applications. The technique uses globaldeadline monotonic priority assignment to clients and the DistributedPriority Ceiling protocol to provide concurrency control andpriorities for server execution. The paper presents a new algorithmfor mapping the potentially large number of unique global prioritiesrequired by this scheduling technique to the restricted set ofpriorities provided by commercial real-time operating systems.This algorithm is called Lowest Overlap First Priority Mapping;we prove that it is optimal among direct priority mapping algorithms.This paper also presents the implementation of these real-timemiddleware scheduling techniques in a Scheduling Service thatmeets the interface proposed for such a service in the Real-TimeCORBA 1.0 standard. Our prototype Scheduling Service is integratedwith the commercial PERTS tool that provides schedulability analysisand automated generation of global and local priorities for clientsand servers.
Smart Homecare System for Health Tele-monitoring

An increasing aged population worldwide puts our medical capabilities to the test. Research and commercial groups are investigating novel ways to care for the aged and chronically ill both in their own homes and in care facilities. This paper describes a prototype we have developed for remote healthcare monitoring. This personalized smart homecare system uses smart phones, wireless sensors, Web servers and IP Webcams. To illustrate the functionality of the prototype we describe a series of typical tele-health monitoring scenarios.
Beneficial cardiometabolic actions of telmisartan plus amlodipine therapy in elderly patients with poorly controlled hypertension.

BACKGROUND
There is a growing body of evidence that blood pressure (BP) level is one of the major determinants of cardiovascular morbidity and mortality in individuals, including elderly people. However, to achieve a target BP level in the elderly is more difficult compared with patients aged <65 years. Current guidelines recommend combination drug therapy with different modes of action for the treatment of elderly patients with moderate hypertension (HT). However, the optimal combination regimen is not well established in elderly HT.


HYPOTHESIS
We hypothesized that combination therapy of telmisartan plus amlodipine would exert favorable cardiometabolic actions in elderly HT.


METHODS
Seventeen elderly patients with essential HT who failed to achieve a target home BP level with treatment of 5 mg amlodipine plus 80 mg valsartan or 8 mg candesartan for at least 2 months were enrolled. Then the patients were assigned to replace their valsartan or candesartan with 40 mg telmisartan. The subjects were instructed to measure their own BP at home every day during the study periods.


RESULTS
Replacement of valsartan or candesartan by telmisartan in amlodipine-treated elderly hypertensive patients showed a significant reduction in morning home systolic BP and evening home systolic and diastolic BP at 12 weeks. Switching to telmisartan significantly increased serum adiponectin level.


CONCLUSIONS
Our present study suggests that combination therapy with telmisartan plus amlodipine may exert more beneficial cardiometabolic effects in elderly patients with HT compared with valsartan or candesartan plus amlodipine treatment.