LLukas22/scidocs huggingface dataset:
A Typology of Technology-Enhanced Tourism Experiences

Experiences constitute the essence of the tourism industry. While literature has recognised the recent impact of technology on experiences, its empirical exploration remains scarce. This study addresses the gap by empirically exploring five leading industry cases to generate a holistic understanding of technology enhanced tourism experiences. The main contribution of this paper lies in the development of a nine-field experience typology matrix based on the increasing intensity of cocreation and technology implementation. The final contribution of this study is the development of an experience hierarchy and discussing its relevance for experience enhancement in tourism research and practice. AUTHORS: Barbara Neuhofer* bneuhofer@bournemouth.ac.uk Dimitrios Buhalis dbuhalis@bournemouth.ac.uk Adele Ladkin aladkin@bournemouth.ac.uk eTourismLab, School of Tourism Bournemouth University Talbot Campus, Fern Barrow Poole, Dorset BH12 5BB United Kingdom PLEASE CITE THIS ARTICLE AS: Neuhofer, B., Buhalis, D., Ladkin, A., 2013. A Typology of Technology-Enhanced Tourism Experiences. DOI: 10.1002/jtr.1958. A Typology of Technology-enhanced Tourism Experiences
Asset Pricing When 'This Time is Different'

Recent evidence suggests that younger people update beliefs in response to aggregate shocks more than older people. We embed this generational learning bias in an equilibrium model in which agents have recursive preferences and are uncertain about exogenous aggregate dynamics. The departure from rational expectations is statistically modest, but generates high average risk premiums varying at generational frequencies, a positive relation between past returns and agents’ future return forecasts, and substantial and persistent over- and undervaluation. Consistent with the model, the price-dividend ratio is empirically more sensitive to macroeconomic shocks when the fraction of young in the population is higher.Received September 14, 2015; editorial decision March 10, 2016 by Editor Stefan Nagel
The natural antioxidant alpha-lipoic acid induces p27(Kip1)-dependent cell cycle arrest and apoptosis in MCF-7 human breast cancer cells.

Unlike normal cells, tumor cells survive in a specific redox environment where the elevated reactive oxygen species contribute to enhance cell proliferation and to suppress apoptosis. Alpha-lipoic acid, a naturally occurring reactive oxygen species scavenger, has been shown to possess anticancer activity, due to its ability to suppress proliferation and to induce apoptosis in different cancer cell lines. Since at the moment little information is available regarding the potential effects of alpha-lipoic acid on breast cancer, in the present study we addressed the question whether alpha-lipoic acid induces cell cycle arrest and apoptosis in the human breast cancer cell line MCF-7. Moreover, we investigated some molecular mechanisms which mediate alpha-lipoic acid actions, focusing on the role of the PI3-K/Akt signalling pathway. We observed that alpha-lipoic acid is able to scavenge reactive oxygen species in MCF-7 cells and that the reduction of reactive oxygen species is followed by cell growth arrest in the G1 phase of the cell cycle, via the specific inhibition of Akt pathway and the up-regulation of the cyclin-dependent kinase inhibitor p27(kip1), and by apoptosis, via changes of the ratio of the apoptotic-related protein Bax/Bcl-2. Thus, the anti-tumor activity of alpha-lipoic acid observed in MCF-7 cells further stresses the role of redox state in regulating cancer initiation and progression.
District mental healthcare plans for five low- and middle-income countries: commonalities, variations and evidence gaps

BACKGROUND
Little is known about the service and system interventions required for successful integration of mental healthcare into primary care across diverse low- and middle-income countries (LMIC).


AIMS
To examine the commonalities, variations and evidence gaps in district-level mental healthcare plans (MHCPs) developed in Ethiopia, India, Nepal, Uganda and South Africa for the PRogramme for Improving Mental health carE (PRIME).


METHOD
A comparative analysis of MHCP components and human resource requirements.


RESULTS
A core set of MHCP goals was seen across all countries. The MHCPs components to achieve those goals varied, with most similarity in countries within the same resource bracket (low income v. middle income). Human resources for advanced psychosocial interventions were only available in the existing health service in the best-resourced PRIME country.


CONCLUSIONS
Application of a standardised methodological approach to MHCP across five LMIC allowed identification of core and site-specific interventions needed for implementation.
Physical activity and bronchial hyperresponsiveness: European Community Respiratory Health Survey II.

BACKGROUND
Identification of the risk factors for bronchial hyperresponsiveness (BHR) would increase the understanding of the causes of asthma. The relationship between physical activity and BHR in men and women aged 28.0-56.5 years randomly selected from 24 centres in 11 countries participating in the European Community Respiratory Health Survey II was investigated.


METHODS
5158 subjects answered questionnaires about physical activity and performed BHR tests. Participants were asked about the frequency and duration of usual weekly exercise resulting in breathlessness or sweating. BHR was defined as a decrease in forced expiratory volume in 1 s of at least 20% of its post-saline value for a maximum methacholine dose of 2 mg.


RESULTS
Both frequency and duration of physical activity were inversely related to BHR. The prevalence of BHR in subjects exercising <or=1, 2-3 and >or=4 times a week was 14.5%, 11.6% and 10.9%, respectively (p<0.001). The corresponding odds ratios were 1.00, 0.78 (95% CI 0.62 to 0.99) and 0.69 (95% CI 0.50 to 0.94) after controlling for potential confounding factors. The frequency of BHR in subjects exercising <1 h, 1-3 h and >or=4 h a week was 15.9%, 10.9% and 10.7%, respectively (p<0.001). The corresponding adjusted odds ratios were 1.00, 0.70 (95% CI 0.57 to 0.87) and 0.67 (95% CI 0.50 to 0.90). Physical activity was associated with BHR in all studied subgroups.


CONCLUSIONS
These results suggest that BHR is strongly and independently associated with decreased physical activity. Further studies are needed to determine the mechanisms underlying this association.
Mechanical Coupling of 2D Resonator Arrays for MEMS Filter Applications

This paper presents a study of mechanical coupling in 2D resonator arrays for filter applications. A robust coupling design for 2D array filters, comprised of weak coupling in one dimension and strong coupling in the second, is demonstrated experimentally and compared with weakly coupled and electrically summed 2D resonator array filters. Effects of inherent disorder in resonator arrays due to fabrication variations are minimized in this mechanical coupling scheme, averaging over resonator mismatch to form a smooth pass-band. The strongly-coupled 2D filter improves insertion loss and ripple without degradation in filter shape factor or stop-band rejection relative to its ID counterpart.
Variations of the Similarity Function of TextRank for Automated Summarization

This article presents new alternatives to the similarity function for the TextRank algorithm for automated summarization of texts. We describe the generalities of the algorithm and the different functions we propose. Some of these variants achieve a significative improvement using the same metrics and dataset as the original publication.
Model for end stage of liver disease (MELD) is better than the Child-Pugh score for predicting in-hospital mortality related to esophageal variceal bleeding.

AIM
The Child Pugh and MELD are good methods for predicting mortality in patients with chronic liver disease. We investigated their performance as risk factors for failure to control bleeding, in-hospital overall mortality and death related to esophageal variceal bleeding episodes.


METHODS
From a previous collected database, 212 cirrhotic patients with variceal bleeding admitted to our hospital were studied. The predictive capability of Child Pugh and MELD scores were compared using c statistics.


RESULTS
The Child-Pugh and MELD scores showed marginal capability for predicting failure to control bleeding (the area under receiver operating characteristics curve (AUROC) values were < 0.70 for both). The AUROC values for predicting in-hospital overall mortality of Child-Pugh and MELD score were similar: 0.809 (CI 95%, 0.710 - 0.907) and 0.88 (CI 95% 0.77- 0.99,) respectively. There was no significant difference between them (p > 0.05). The AUROC value of MELD for predicting mortality related to variceal bleeding was higher than the Child-Pugh score: 0.905 (CI 95% 0.801-1.00) vs 0.794 (CI 95% 0.676 - 0.913) respectively (p < 0.05).


CONCLUSIONS
MELD and Child-Pugh were not efficacious scores for predicting failure to control bleeding. The Child-Pugh and MELD scores had similar capability for predicting in-hospital overall mortality. Nevertheless, MELD was significantly better than Child-Pugh score for predicting in-hospital mortality related to variceal bleeding.
Congenital Anomalies of the Hand--Principles of Management.

Physicians who specialize in pediatric orthopedics and hand surgery frequently encounter congenital hand abnormalities, despite their relative rarity. The treating physician should be aware of the associated syndromes and malformations that may, in some cases, be fatal if not recognized and treated appropriately. Although these congenital disorders have a wide variability, their treatment principles are similar in that the physician should promote functional use and cosmesis for the hand. This article discusses syndactyly, preaxial polydactyly and post-axial polydactyly, and the hypoplastic thumb.
Psychometric evaluation of a new questionnaire measuring treatment satisfaction in hypothyroidism: the ThyTSQ.

OBJECTIVES
There is a clinical impression of dissatisfaction with treatment for hypothyroidism among some patients. Psychometric properties of the new ThyTSQ questionnaire are evaluated. The questionnaire, measuring patients' satisfaction with their treatment for hypothyroidism, has two parts: the seven-item ThyTSQ-Present and four-item ThyTSQ-Past, measuring satisfaction with present and past treatment, respectively, on scales from 6 (very satisfied) to 0 (very dissatisfied).


METHODS
The questionnaire was completed once by 103 adults with hypothyroidism, age (mean [SD]) 55.2 [14.4], range 23-84 years (all treated with thyroxine).


RESULTS
Completion rates were very high. Internal consistency reliability was excellent for both ThyTSQ-Present and ThyTSQ-Past (Cronbach's alpha = 0.91 and 0.90, respectively [N = 102 and 103]). Principal components analyses indicated that the seven items of the ThyTSQ-Present and the four items of the ThyTSQ-Past could be summed into separate Present Satisfaction and Past Satisfaction total scores. Mean Present Satisfaction was 32.5 (7.8), maximum range 0-42, and mean Past Satisfaction was 17.5 (6.1), maximum range 0-24, indicating considerable room for improvement. Patients were least satisfied with their present understanding of their condition, mean 4.2 (1.7) (maximum range 0-6), and with information provided about hypothyroidism around the time of diagnosis, mean 3.9 (1.8) (maximum range 0-6).


CONCLUSIONS
The ThyTSQ is highly acceptable to patients with hypothyroidism (excellent completion rates), and has established internal consistency reliability. It will assist health professionals in considering psychological outcomes when treating people with hypothyroidism, and is suitable for clinical trials and routine clinical monitoring.
A randomized controlled trial to evaluate the effectiveness of a brief, behaviorally oriented intervention for cancer-related fatigue.

BACKGROUND
It has been shown that nonpharmacologic interventions are effective management techniques for cancer-related fatigue (CRF) in cancer survivors. However, few studies have investigated their effectiveness in patients who are receiving chemotherapy. In this study, the authors tested the effectiveness of a brief behaviorally oriented intervention in reducing CRF and improving physical function and associated distress in individuals who were receiving chemotherapy.


METHODS
For this randomized controlled trial, 60 patients with cancer were recruited and received either usual care or the intervention. The intervention was delivered on an individual basis on 3 occasions over a period from 9 weeks to 12 weeks, and the objective of the intervention was to alter fatigue-related thoughts and behavior. Primary outcomes were assessed as follows: CRF using the Visual Analogue Scale-Global Fatigue; physical functioning using the European Organization for Research and Treatment of Cancer Quality-of-Life Core 30 Questionnaire, and CRF-associated distress using the Fatigue Outcome Measure. Assessments were made on 4 occasions: at baseline (T0), at the end of chemotherapy (T1), 1 month after chemotherapy (T2), and 9 months after recruitment (T3). Normally distributed data were analyzed using t tests and random-slope/random-intercept mixed models.


RESULTS
The intervention demonstrated a trend toward improved CRF, although this effect was reduced once confounders had been controlled statistically. There was a significant improvement in physical functioning (coefficient, 10.0; 95% confidence interval, 2.5-17.5; P = .009), and this effect remained once the confounding effects of mood disturbance and comorbid disorders were controlled statistically. No decrease in fatigue-related distress was detected.


CONCLUSIONS
The behaviorally oriented intervention brought about significant improvements in physical functioning, indicated a trend toward improved CRF, but detected no effect for fatigue-related distress.
Vygotsky, Piaget, and Education: a reciprocal assimilation of theories and educational practices

Seeking a rapprochement between Vygotskians and Piagetians, the theories of Piaget and Vygotsky are compared, and educational extensions by their followers are examined. A paradox in Vygotsky’s theory is highlighted, where evidence is found both for claiming that Vygotsky was a behaviorist and that he was a constructivist. Similarities in the two theories are presented: social factors as having a central role in child development, the transformative nature of internalization, and the individual as what develops. Differences in the theories pertain to the nature of the stimulus, nature, and origin of psychological instruments, nature of self-regulation and novelty in development, direction of development, the concept of social development, and the role of language in development. Because practical applications of theories often clarify the theories, some educational extensions of Vygotsky’s theory are critiqued from a Piagetian constructivist perspective, and, in contrast, constructivist educational interpretations of Vygotsky’s work are noted. Aspects of Piaget’s theory emphasized by educators are presented, and educational practices inspired by this theory are outlined. A rapprochement is sought, with consideration of convergences in educational practices of followers of Piaget and Vygotsky, sources of difficulty for rapprochement, and changes necessary in educational theories of followers of both Piaget and Vygotsky.
Simple versus complex forecasting : The evidence

This article introduces the Special Issue on simple versus complex methods in forecasting. Simplicity in forecasting requires that (1) method, (2) representation of cumulative knowledge, (3) relationships in models, and (4) relationships among models, forecasts, and decisions are all sufficiently uncomplicated as to be easily understood by decision-makers. Our review of studies comparing simple and complex methods— including those in this special issue—found 97 comparisons in 32 papers. None of the papers provide a balance of evidence that complexity improves forecast accuracy. Complexity increases forecast error by 27 percent on average in the 25 papers with quantitative comparisons. The finding is consistent with prior research to identify valid forecasting methods: all 22 previously identified evidence-based forecasting procedures are simple. Nevertheless, complexity remains popular among researchers, forecasters, and clients. Some evidence suggests that the popularity of complexity may be due to incentives: (1) researchers are rewarded for publishing in highly ranked journals, which favor complexity; (2) forecasters can use complex methods to provide forecasts that support decision-makers’ plans; and (3) forecasters’ clients may be reassured by incomprehensibility. Clients who prefer accuracy should accept forecasts only from simple evidence-based procedures. They can rate the simplicity of forecasters’ procedures using the questionnaire at simple-forecasting.com.
Text-to-speech conversion technology

The historical and theoretical bases of contemporary high-performance text-to-speech (TTS) systems and their current design are discussed. The major elements of a TTS system are described, with particular reference to vocal tract models. The stages involved in the process of converting text into speech parameters are examined, covering text normalization, word pronunciation, prosodies, phonetic rules, voice tables, and hardware implementation. Examples are drawn mainly from Berkeley Speech Technologies' proprietary text-to-speech system, T-T-S, but other approaches are indicated briefly.<<ETX>>
An energy minimization reconstruction algorithm for multivalued discrete tomography

We propose a new algorithm for multivalued discrete tomogra phy, that reconstructs images from few projections by approximating the minimum of a suitably constructed ener gy function with a deterministic optimization method. We also compare the proposed algorithm to other reco nstruction techniques on software phantom images, in order to prove its applicability.
What Additional Factors Beyond State-of-the-Art Analytical Methods Are Needed for Optimal Generation and Interpretation of Biomonitoring Data?

BACKGROUND
The routine use of biomonitoring (i.e., measurement of environmental chemicals, their metabolites, or specific reaction products in human biological specimens) to assess internal exposure (i.e., body burden) has gained importance in exposure assessment.


OBJECTIVES
Selection and validation of biomarkers of exposure are critical factors in interpreting biomonitoring data. Moreover, the strong relation between quality of the analytical methods used for biomonitoring and quality of the resulting data is well understood. However, the relevance of collecting, storing, processing, and transporting the samples to the laboratory to the overall biomonitoring process has received limited attention, especially for organic chemicals.


DISCUSSION
We present examples to illustrate potential sources of unintended contamination of the biological specimen during collection or processing procedures. The examples also highlight the importance of ensuring that the biological specimen analyzed both represents the sample collected for biomonitoring purposes and reflects the exposure of interest.


CONCLUSIONS
Besides using high-quality analytical methods and good laboratory practices for biomonitoring, evaluation of the collection and handling of biological samples should be emphasized, because these procedures can affect the samples integrity and representativeness. Biomonitoring programs would be strengthened with the inclusion of field blanks.
Survey of Automated Vulnerability Detection and Exploit Generation Techniques in Cyber Reasoning Systems

Software is everywhere, from mission critical systems such as industrial power stations, pacemakers and even household appliances. This growing dependence on technology and the increasing complexity software has serious security implications as it means we are potentially surrounded by software that contain exploitable vulnerabilities. These challenges have made binary analysis an important area of research in computer science and has emphasized the need for building automated analysis systems that can operate at scale, speed and efficacy; all while performing with the skill of a human expert. Though great progress has been made in this area of research, there remains limitations and open challenges to be addressed. Recognizing this need, DARPA sponsored the Cyber Grand Challenge (CGC), a competition to showcase the current state of the art in systems that perform; automated vulnerability detection, exploit generation and software patching. This paper is a survey of the vulnerability detection and exploit generation techniques, underlying technologies and related works of two of the winning systems Mayhem and Mechanical Phish. Keywords—Cyber reasoning systems, automated binary analysis, automated exploit generation, dynamic symbolic execution, fuzzing
Prospective evaluation of dietary treatment in childhood constipation: high dietary fiber and wheat bran intake are associated with constipation amelioration.

OBJECTIVES
The aim of the study was to evaluate, over 24 months, the intake of dietary fiber (DF) and the bowel habit (BH) of constipated children advised a DF-rich diet containing wheat bran.


PATIENTS AND METHODS
BH and dietary data of 28 children with functional constipation defined by the "Boston criteria" were obtained at visit 1 (V1, n = 28) and at 4 follow-up visits (V2-V5, n = 80). At each visit the BH was rated BAD (worse/unaltered; improved but still complications) or RECOVERY (REC) (improved, no complications; asymptomatic), and a food intake questionnaire was applied. DF intake was calculated according to age (year) + 5 to 10 g/day and bran intake according to international tables. Nonparametric statistics were used.


RESULTS
Median age (range) was 7.25 years (0.25-15.6 years); 21 children underwent bowel washout (most before V1/V2), and 14 had the last visit at V3/V4. DF intake, bran intake, and the BH rate significantly increased at V2 and remained higher than at V1 through V2 to V5. At V1, median DF intake was 29.9% below the minimum recommended and at the last visit 49.9% above it. Twenty-four children accepted bran at 60 visits, at which median bran intake was 20 g/day and median proportion of DF due to bran 26.9%. Children had significantly higher DF and higher bran intake at V2 to V5 at which they had REC than at those at which they presented BAD BH. DF intake > age +10 g/day was associated with bran acceptance and REC. At the last visit 21 children presented REC (75%); 20 of them were asymptomatic and 18 were off washout/laxatives.


CONCLUSIONS
High DF and bran intake are feasible in constipated children and contribute to amelioration of constipation.