LLukas22/scidocs huggingface dataset:
Blunted vagal reactivity predicts stress-precipitated tobacco smoking

Long-term smoking can lead to changes in autonomic function, including decreased vagal tone and altered stress responses. One index of the inability to adapt to stress may be blunted vagal reactivity. Stress is a primary mechanism involved in relapse to smoking, but mechanisms leading to stress-precipitated relapse are not well understood. Using an experimental paradigm of stress-precipitated smoking behavior, we examined whether autonomic reactivity mediates the relationship between stress and smoking. High-frequency heart rate variability (HF-HRV), a putative measure of vagal tone, and the ratio of low-to-high frequency HRV (LF/HF), a measure of sympathovagal balance, were assessed. Using a within-subjects design, 32 nicotine–dependent, 15-h abstinent smokers (a subgroup from McKee et al. (J Psychopharmacol 25(4):490–502, 2011)) were exposed to individualized script-driven imagery of stressful and relaxing scenarios and assessed on the ability to resist smoking and subsequent ad-lib smoking. HRV was monitored throughout each laboratory session (maximum 60 min following imagery). As expected, stress and ad-lib smoking additively decreased HF-HRV and increased LF/HF. Blunted stress-induced HF-HRV responses reflecting decreased vagal reactivity were associated with less time to initiate smoking and increased craving relief and reinforcement from smoking. These relationships were specific to HF-HRV following stress as neither baseline HF-HRV, HF-HRV following relaxing imagery, or LF/HF predicted smoking behavior. The current findings are the first to experimentally demonstrate that stress-precipitated decreased vagal reactivity predicts the ability to resist smoking. Findings suggest that strategies that normalize vagal reactivity in early abstinent smokers may lead to improved smoking cessation outcomes.
Lopinavir/ritonavir monotherapy after 24 weeks of second-line antiretroviral therapy in Africa: a randomized controlled trial (SARA).

BACKGROUND
Boosted protease inhibitor (bPI) monotherapy (bPImono) potentially has substantial cost, safety and operational benefits. It has never been evaluated as second-line antiretroviral therapy (ART) in Africa.


METHODS
After 24 weeks of lopinavir/ritonavir-containing second-line therapy, DART participants were randomized to remain on combination therapy (CT), or change to bPImono maintenance (SARA trial; ISRCTN53817258). Joint primary end points were CD4(+) T-cell changes 24 weeks later and serious adverse events (SAEs); retrospectively assayed viral load (VL) was a secondary end point. Analyses were intention-to-treat.


RESULTS
A total of 192 participants were randomized to CT (n=95) or bPImono (n=97) and followed for median 60 weeks (IQR 45-84). Participants received median 4.0 years (IQR 3.5-4.4) first-line ART. Median CD4(+) T-cell count at first-line failure was 86 cells/mm(3) (47-136), increasing to 245 cells/mm(3) (173-325) after 24-week induction when 77% had VL<50 copies/ml. Overall, 44 (23%) were receiving second-line therapy with bPI and nucleoside reverse transcriptase inhibitors (NRTI) only, and 148 (77%) with bPI plus non-NRTI (NNRTI) with or without NRTI. At 24 weeks after randomization to CT versus bPImono, mean CD4(+) T-cell increase was 42 (CT, n=85) versus 49 cells/mm(3) (bPImono, n=88; adjusted difference 13 [95% CI -15, 43], P=0.37; non-inferior compared with predetermined non-inferiority margin [-33]). Virological suppression was greater for CT versus bPImono (trend P=0.009): 77% (70/91) versus 60% (56/94) were <50 copies/ml, and 5% (5) versus 14% (13) were ≥1,000 copies/ml, respectively. A total of 0 (0%) versus 5 (5%) participants had major protease inhibitor mutations and 3 (3%) versus 0 (0%) new NNRTI/NRTI mutations were detected during follow-up. Two participants (1 CT and 1 bPImono) died >24 weeks after randomization, and 5 (2 CT and 3 bPImono) experienced SAEs (P=0.51).


CONCLUSIONS
bPImono following a 24-week second-line induction was associated with similar CD4(+) T-cell response, but increased low-level viraemia, generally without protease inhibitor resistance. Longer-term trials are needed to provide definitive evidence about effectiveness in Africa.
Brand Concepts as Representations of Human Values : Do Cultural Congruity and Compatibility Between Values Matter ?

meaning (overall M = 5.89) and significantly higher than with any of the other three abstract meanings (overall M = 2.05, all ps < .001). Procedure. Under a cover story of studying advertising slogans, participants saw one of the 22 target brands and thought about its abstract concept in memory. They were then presented, on a single screen, with four alternative slogans (in random order) for the target brand and were asked to rank the slogans, from 1 (“best”) to 4 (“worst”), in terms of how well the slogan fits the image of the target brand. Each slogan was intended to distinctively communicate the abstract meaning associated with one of the four high-levelmeaning associated with one of the four high-level brand value dimensions uncovered in the pilot study. After a series of filler tasks, participants indicated their attitude toward the brand on a seven-point scale (1 = “very unfavorable,” and 7 = “very favorable”). Ranking of the slogans. We conducted separate nonparametric Kruskal-Wallis tests on each country’s data to evaluate differences in the rank order for each of the four slogans among the four types of brand concepts. In all countries, the tests were significant (the United States: all 2(3, N = 539) ≥ 145.4, all ps < .001; China: all 2(3, N = 208) ≥ 52.8, all ps < .001; Canada: all 2(3, N = 380) ≥ 33.3, all ps < .001; Turkey: all 2(3, N = 380) ≥ 51.0, all ps < .001). We pooled the data from the four countries and conducted follow-up tests to evaluate pairwise differences in the rank order of each slogan among the four brand concepts, controlling for Type I error across tests using the Bonferroni approach. The results of these tests indicated that each slogan was ranked at the top in terms of favorability when it matched the brand concept (self-enhancement brand concept: Mself-enhancement slogan = 1.77; openness brand FIGURE 2 Structural Relations Among Value Dimensions from Multidimensional Scaling (Pilot: Study 1) b = benevolence, t = tradition, c = conformity, sec = security S e l f E n h a n c e m e n t IN D VID U A L C O N C ER N S C O LL EC TI VE C O N C ER N S
Phytochrome B and AGB1 Coordinately Regulate Photomorphogenesis by Antagonistically Modulating PIF3 Stability in Arabidopsis.

Phytochrome B (phyB), the primary red light photoreceptor, promotes photomorphogenesis in Arabidopsis by interacting with the basic helix-loop-helix transcriptional factor PIF3 and inducing its phosphorylation and degradation. Heterotrimeric G proteins are known to regulate various developmental processes in plants and animals. In Arabidopsis, the G-protein β subunit AGB1 is known to repress photomorphogenesis. However, whether and how phyB and AGB1 coordinately regulate photomorphogenesis are largely unknown. Here we show that phyB physically interacts with AGB1 in a red light-dependent manner and that AGB1 interacts directly with PIF3. Moreover, we demonstrate that the AGB1-PIF3 interaction inhibits the association of PIF3 with phyB, leading to reduced phosphorylation and degradation of PIF3, whereas the phyB-AGB1 interaction represses the association of PIF3 with AGB1, resulting in enhanced phosphorylation and degradation of PIF3. Our results suggest that phyB and AGB1 antagonistically regulate PIF3 stability by dynamically interacting with each other and PIF3. This dynamic mechanism may allow plants to balance phyB and G-protein signaling to optimize photomorphogenesis.
“Miss, nominalization is a nominalization:” English language learners’ use of SFL metalanguage and their literacy practices

This study explores how an elementary school teacher in the United States used systemic functional linguistics (SFL) and genre-based pedagogy to design and reflect on academic literacy instruction and how Spanish–English bilinguals took-up SFL metalanguage in learning to read and write historical and scientific explanations about culturally relevant topics. Based on a longitudinal analysis of changes in student writing samples and district and state test scores over an academic year, the findings indicate that instruction in SFL metalanguage helped students recognize and name linguistic patterns within and across disciplinary texts and expand their semiotic resources, especially as these resources relate to realizing meaning in print. The implications of this study relate to the strategic role SFL-based pedagogy can play in supporting teachers and bilinguals in critically navigating English-only mandates and the discourses of standardization and accountability in the United States. © 2014 Elsevier Inc. All rights reserved.
About the Great Lakes Legacy Act

The Great Lakes Legacy Act provided federal funding to accelerate the pace of contaminated sediment remediation in AOCs. The GLRI's Legacy Act has been a tremendous success.
A new UPS scheme provides harmonic suppression and input power factor correction

A new parallel processing uninterruptible power supply (UPS) configuration is proposed in this paper. It provides active power line conditioning to minimize mains current distortion. This performance is superior to a conventional UPS. A prototype has been implemented and tested to verify its performance. The experimental results show that the input power factor of the proposed UPS is nearly unity, and the total harmonic distortion (THD) of the input current under nonlinear loading is only 3.618% for a mains voltage with THD of 1.633%.
Electronic Human Resources Management in an E-Business Environment

This special issue on Electronic Human Resources Management (E-HRM) in an E-Business environment looks t opportunities nd ch llenges ssoci ted with recruiting nd developing firm‟s workforce in a digital world characterized by endemic talent scarcity, changing values and shifting onand offline behaviors of candidates and employees. We first draw on a Delphi study with leading HR executives from 25 internationally renowned large firms and on a quantitative survey with 144 HR managers from German top 1,000 firms to delineate the key trends and issues for modern HR executives. Demographic challenges and the war for talent are seen as the most important trends in firms of all sizes and in all industries, even ahead of, for example, social media or the global economic crisis. Resulting from these trends, our survey reve ls th t HR m n gers‟ most pressing ch llenges re st ff retention nd internal and external employer branding. Overall, the results emphasize the importance for an E-HRM that needs to be both effective – adequately fill vacancies – and efficient – make best use of scarce resources. The papers in the special issue address some of the open issues identified. Overall, in a peer-review process two out of nine submitted articles were selected for the special issue (22 per cent acceptance). The first paper by Stefan Strohmeier scrutinizes how e-portfolios can improve e-recruiting and talent management. The second paper by Sharna Wiblen, David Grant and Kristine Dery uses a single case study to learn how a shift from HRM to E-HRM can affect talent management and people in n org niz tion nd tr nsform firm‟s IT nd HR function.
Postnatal depression and infant growth and development in low income countries: a cohort study from Goa, India.

BACKGROUND
Postnatal depression is a recognised cause of delayed cognitive development in infants in developed countries. Being underweight is common in South Asia.


AIMS
To determine whether postnatal depression contributes to poor growth and development outcomes in Goa, India.


METHODS
Cohort study for growth outcomes with nested case-control study for developmental outcomes. A total of 171 babies were weighed and measured at 6-8 weeks following birth. The following measures were used: Edinburgh Postnatal Depression Scale for maternal mood, and sociodemographic and infant health variables. Outcome measures were: weight (<5th centile), length (<5th centile), and Developmental Assessment Scale for Indian Infants scores at six months.


RESULTS
Postnatal depression was a strong, and independent, predictor of low weight and length and was significantly associated with adverse mental development quotient scores.


CONCLUSIONS
This study provides evidence for the first time that postnatal depression, a potentially treatable disorder, is a cause of poor growth and development in South Asia.
Design and simulation of an electromagnetic aircraft launch system

This paper describes the basic design, refinement and verification using finite element analysis (FEA), and operational simulation using the virtual test bed (VTB), of a range of candidate linear machines for an electromagnetic aircraft launching system (EMALS) for the aircraft carrier of the future. Choices of basic machine format, and procedures for determining basic dimensions are presented. A detailed design is presented for a permanent magnet version, and wound field coil and induction machine versions are introduced. The long armature - short field geometry is discussed, and in particular the impact of this geometry on the scale of the power electronic drive system is presented.
A randomized trial comparing the diagnostic yield of rigid and semirigid thoracoscopy in undiagnosed pleural effusions.

BACKGROUND
Thoracoscopic pleural biopsy increases the diagnostic yield of pleural effusions undiagnosed after thoracentesis and is superior to closed pleural biopsy. Medical thoracoscopy can be performed using the rigid thoracoscope or the semirigid thoracoscope (pleuroscope). In this randomized trial, we compare the efficacy and safety of the 2 thoracoscopes.


METHODS
Subjects with undiagnosed exudative pleural effusions were randomly assigned to undergo pleural biopsy with either the rigid or the semirigid thoracoscope. The primary outcome was the diagnostic yield of the procedure, while the secondary outcomes were requirement of sedative/analgesic agents, scar size, biopsy sample size, and the operator's view of the procedure.


RESULTS
Of the 145 screened subjects with exudative pleural effusions, 90 were randomized to undergo thoracoscopy with the 2 thoracoscopes (n = 45 each). The diagnostic yield of rigid thoracoscopy was superior to semirigid thoracoscopy (97.8% vs 73.3%, P = .002) on an intention-to-treat analysis but was similar (100% vs 94.3%, P = .18) in those with successful biopsy. The requirement of sedative/analgesic agents was higher in the rigid thoracoscopy arm. The scar size was slightly larger (mean ± SD, 23.1 ± 4 vs 18.7 ± 3.2 mm, P = .0001), whereas the biopsy sample size was distinctly larger in the rigid arm (mean ± SD, 13.9 ± 4.4 vs 4.4 ± 1.4 mm, P = .001). The operator-rated visual analog scale score for the ease of taking a biopsy sample was significantly higher with the rigid instrument (mean ± SD, visual analog scale 86 ± 12 vs 79 ± 12 mm, P = .01), while the quality of image was superior in the semirigid arm (mean ± SD, visual analog scale 88 ± 7 vs 92 ± 5 mm, P = .002). The number of complications were similar in the 2 groups.


CONCLUSIONS
Rigid thoracoscopy was found to be superior to semirigid thoracoscopy overall, but the diagnostic yield was similar if pleural biopsy could be successfully performed. Due to the small sample size, a larger study is required to define the usefulness and choice between the 2 procedures. (ClinicalTrials.gov registration NCT01726556).
A literature review on the vehicle routing problem with multiple depots

http://dx.doi.org/10.1016/j.cie.2014.10.029 0360-8352/ 2014 Elsevier Ltd. All rights reserved. ⇑ Corresponding author. E-mail addresses: jairo.montoya@unisabana.edu.co (J.R. Montoya-Torres), julian. lopez@eic-sas.com (J. López Franco), nietos@uninorte.edu.co (S. Nieto Isaza), healfelizzola@unisalle.edu.co (H. Felizzola Jiménez). Jairo R. Montoya-Torres a,⇑, Julián López Franco , Santiago Nieto Isaza , Heriberto Felizzola Jiménez , Nilson Herazo-Padilla e,f
The Swiss disease: Facts and artefacts. A reply to Kehoe and Prescott

This paper investigates the claim made by Kehoe and Prescott (2002) that Switzerland and New Zealand experienced 'great depressions' in the last two decades. We question the appropriateness of the measure used by Kehoe and Prescott (GDP per working-age person) and propose a more accurate measure to compare economic performance on a consistent basis, namely, GDP per hour worked which is also adjusted for terms of trade changes and investment in tangibles. Based on this yardstick, the difference in economic performance between the US and Switzerland turns out to be largely a statistical artefact and Kehoe and Prescott's conditions for a 'great depression.' (Copyright: Elsevier)
Acoustical response of hair receptors in insects

A detailed mechanical model is developed to account for the behaviour of hair-like acoustical sensory receptors in insects. For the small hair diameters commonly found, it is concluded that the force acting on the moving hair is caused almost entirely by the viscosity of the air, as analyzed long ago by Stokes. The result of this viscous force is to provide a bending moment about the base of the hair that is proportional to the acoustic particle velocity but that lags behind it by about 135°. In addition the viscous force increases the moment of inertia of the hair by a large and frequency dependent addition, and provides a viscous damping term of sufficient magnitude to reduce the Q value to near unity. The measurements of Tautz (1977) on the thoracic hairs of the caterpillarBarathra brassicae are discussed in detail in terms of the model. Many of these observations are well accounted for, though a few discrepancies remain.
Effectiveness of alcohol treatment interventions integrated into routine tuberculosis care in Tomsk, Russia.

AIMS
To test the feasibility and effectiveness of brief counseling intervention (BCI) and naltrexone integrated into tuberculosis (TB) care in Tomsk, Russia.


DESIGN
Using a factorial randomized controlled trial design, patients were randomized into: naltrexone (NTX), brief behavioral compliance enhancement therapy (BBCET), treatment as usual (TAU) and BCI.


SETTING AND PARTICIPANTS
In the Tomsk Oblast, hospitalized TB patients diagnosed with alcohol use disorders (AUDs) by the DSM-IV were referred at the start of TB treatment. Of the 196 participants, the mean age was 41 years and 82% were male. Severe TB (84.7% had cavitary disease) and smoking (92.9%) were common. The majority had a diagnosis of an AUD (63.0%); 27.6% reported nearly daily drinking and consumed a median of 16 standard drinks per day.


MEASUREMENTS
Primary outcomes were 'favorable' TB outcome (cured, completed treatment) and change in mean number of abstinent days in the last month of study compared with baseline. Change in mean number of heavy drinking days, defined as four drinks per day and five drinks per day for women and men, respectively, and TB adherence, measured as percentage of doses taken as prescribed under direct observation, were secondary outcomes. Analysis based on 'intention-to-treat' was performed for multivariable analysis.


FINDINGS
Primary TB and alcohol end-points between naltrexone and no-naltrexone or BCI and no-BCI groups did not differ significantly. TB treatment adherence and change in number of heavy drinking days also did not differ significantly among treatment arms. Among individuals with a prior quitting attempt (n = 111), naltrexone use was associated with an increased likelihood of favorable TB outcomes (92.3% versus 75.9%, P = 0.02).


CONCLUSIONS
In Tomsk Oblast, Russia, tuberculosis patients with severe alcohol use disorders who were not seeking alcohol treatment did not respond to naltrexone or behavioral counselling integrated into tuberculosis care; however, those patients with past attempts to quit drinking had improved tuberculosis outcomes.
Phase 1 dose-escalation, pharmacokinetic, and cerebrospinal fluid distribution study of TAK-285, an investigational inhibitor of EGFR and HER2

Introduction This phase 1 study assessed safety, maximum tolerated dose (MTD), pharmacokinetics, cerebrospinal fluid (CSF) distribution, and preliminary clinical activity of the receptor tyrosine kinase inhibitor TAK-285. Methods Patients with advanced, histologically confirmed solid tumors and Eastern Cooperative Oncology Group performance status ≤2 received daily oral TAK-285; daily dose was escalated within defined cohorts until MTD and recommended phase 2 dose (RP2D) were determined. Eleven patients were enrolled into an RP2D cohort. Blood samples were collected from all cohorts; CSF was collected at pharmacokinetic steady-state from RP2D patients. Tumor responses were assessed every 8 weeks per Response Evaluation Criteria in Solid Tumors. Results Fifty-four patients were enrolled (median age 60; range, 35–76 years). The most common diagnoses were cancers of the colon (28 %), breast (17 %), and pancreas (9 %). Escalation cohorts evaluated doses from 50 mg daily to 500 mg twice daily; the MTD/RP2D was 400 mg twice daily. Dose-limiting toxicities included diarrhea, hypokalemia, and fatigue. Drug absorption was fast (median time of maximum concentration was 2–3 h), and mean half-life was 9 h. Steady-state average unbound CSF concentration (geometric mean 1.54 [range, 0.51–4.27] ng/mL; n = 5) at the RP2D was below the 50 % inhibitory concentration (9.3 ng/mL) for inhibition of tyrosine kinase activity in cells expressing recombinant HER2. Best response was stable disease (12 weeks of nonprogression) in 13 patients. Conclusions TAK-285 was generally well tolerated at the RP2D. Distribution in human CSF was confirmed, but the free concentration of the drug was below that associated with biologically relevant target inhibition.
Animal behaviour, animal welfare and the scientific study of affect

Many questions about animal welfare involve the affective states of animals (pain, fear, distress) and people look to science to clarify these issues as a basis for practices, policies and standards. However, the science of the mid twentieth century tended to be silent on matters of animal affect for both philosophical and methodological reasons. Philosophically, under the influence of Positivism many scientists considered that the affective states of animals fall outside the scope of science. Certain methodological features of the research also favoured explanations that did not involve affect. The features included the tendency to rely on abstract, quantitative measures rather than description, to use controlled experiments more than naturalistic observation, and to focus on measures of central tendency (means, medians) rather than individual differences. Much animal welfare science has dropped the philosophical stance but retained most of the methodological features. Thus, animal welfare scientists attempt to understand affect through quantitative measures, often in controlled experiments, with relatively little focus on individual differences. An alternative paradigm, seen in the work of Jane Goodall, Barbara Smuts and others, made a fundamental departure from these methodological features. These scientists collected qualitative, narrative data as well as quantitative; they described complex behaviour rather than measuring selected abstract features; and they attempted to understand the unique features of individual animals rather than averages for a species or type. Data produced by this alternative paradigm almost require scientists to involve affect in order to achieve plausible explanations of behaviour. Suitably developed, the alternative paradigm may provide a useful tool for fundamental studies relevant to animal affect and animal welfare. 2009 Elsevier B.V. All rights reserved.