LLukas22/scidocs huggingface dataset:
Approximate Inverse Preconditioners via Sparse-Sparse Iterations

The standard incomplete LU (ILU) preconditioners often fail for general sparse in-deenite matrices because they give rise tòunstable' factors L and U. In such cases, it may be attractive to approximate the inverse of the matrix directly. This paper focuses on approximate inverse preconditioners based on minimizing kI ? AMk F , where AM is the preconditioned matrix. An iterative descent-type method is used to approximate each column of the inverse. For this approach to be eecient, the iteration must be done in sparse mode, i.e., with`sparse-matrix by sparse-vector' operations. Numerical dropping is applied to maintain sparsity; compared to previous methods, this is a natural way to determine the sparsity pattern of the approximate inverse. This paper describes Newton, `global' and column-oriented algorithms, and discusses options for initial guesses, self-preconditioning, and dropping strategies. Some limited theoretical results on the properties and convergence of approximate inverses are derived. Numerical tests on problems from the Harwell-Boeing collection and the FIDAP uid dynamics analysis package show the strengths and limitations of approximate inverses. Finally, some ideas and experiments with practical variations and applications are presented.
The impact of motor development on typical and atypical social cognition and language : A systematic review

Background: Motor development allows infants to gain knowledge of the world but its vital role in social development is often ignored. Method: A systematic search for papers investigating the relationship between motor and social skills was conducted , including research in typical development and in Developmental Coordination Disorder, Autism Spectrum Disorders and Specific Language Impairment. R sults: The search identified 42 studies, many of which highlighted a significant relationship between motor skills and the development of social cognition, language and social interactions. Conclusions: This complex relationship requires more attention from researchers and practitioners, allowing the development of more tailored intervention techniques for those at risk of motor, social and language difficulties. Key Practitioner Message  Significant relationships exist between the development of motor skills, social cognition, language and social interactions in typical and atypical development  Practitioners should be aware of the relationships between these aspects of development and understand the impact that early motor difficulties may have on later social skills  Complex relationships between motor and social skills are evident in children with ASD, DCD and SLI  Early screening and more targeted interventions may be appropriate
Acute Care QUAliTy in chronic Kidney disease (ACQUATIK): a prospective cohort study exploring outcomes of patients with chronic kidney disease

INTRODUCTION
Chronic kidney disease (CKD) is common and carries a high risk of morbidity, including hospital admissions and readmissions and mortality. This is largely attributed to an increased risk of cardiovascular disease. Patients with CKD are less likely to receive evidence-based treatments for cardiovascular disease. However, these treatments are based on trials which generally exclude patients with CKD. It is therefore unclear whether this patient group derives the same benefits without an increased risk of adverse effects.


METHODS AND ANALYSIS
The Acute Care QUAliTy in chronic Kidney disease (ACQUATIK) study is a prospective, observational, multicentre cohort study. Over 4000 patients will be recruited with an enrolment period of 2 years and a follow-up period of 2-4 years. Patients under follow-up by a renal team will be excluded. Data will be obtained from patient and hospital records during the index admission. Preadmission data will be extracted from general practice records based on the Quality and Outcomes Framework. Diagnosis, comorbidities and procedure data pertaining to the index and subsequent admissions will be extracted from the Hospital Episode Statistics database and long-term mortality data will be tracked using the Office of National Statistics. This information will allow us to examine a complete patient journey through primary and secondary care, providing unequalled levels of information on treatment and outcomes of patients with CKD. The combined data set will be used to compare outcomes and treatments among patients with CKD versus patients without CKD. The primary end point is hospital readmission rates. The relationship between age, sex, ethnicity, socioeconomic status and concurrent comorbidities will be analysed to determine their influence on outcomes and treatments.


ETHICS AND DISSEMINATION
The ACQUATIK study has been approved by the NRES Committee West Midlands-South Birmingham-Reference 13/WM/0317. The results from ACQUATIK will be submitted for publication in peer-reviewed journals and presented at primary and secondary care conferences.


TRIAL REGISTRATION NUMBER
ISRCTN37237454.
CIP 방법을 사용한 해석법

Page iv © 1999 Massachusetts Institute of Technology All rights reserved. No part of this book may be reproduced in any form by any electronic or mechanical means (including photocopying, recording, or information storage and retrieval) without permission in writing from the publisher. Set in New Baskerville by Wellington Graphics. Printed and bound in the United States of America. Library of Congress Cataloging-in-Publication Data
Granulocyte-macrophage colony-stimulating factor induces modest increases in plasma human immunodeficiency virus (HIV) type 1 RNA levels and CD4+ lymphocyte counts in patients with uncontrolled HIV infection.

BACKGROUND
Studies have reported that plasma human immunodeficiency virus type 1 (HIV-1) RNA levels and CD4+ lymphocyte counts in HIV-infected patients improved after treatment with granulocyte-macrophage colony-stimulating factor (GM-CSF).


METHODS
In AIDS Clinical Trials Group Protocol 5041, 116 patients were enrolled in a double-blind, randomized, placebo-controlled clinical trial of 16 weeks of 250 microg of GM-CSF administered subcutaneously 3 times/week, followed by open-label treatment for an additional 32 weeks. Patients had stable baseline plasma HIV-1 RNA levels of > or =1500 copies/mL and received constant antiretroviral regimens through at least the first 16 weeks of the study.


RESULTS
After 16 weeks, the GM-CSF group tended to have greater, though clinically insignificant, increases in plasma HIV-1 RNA levels, compared with the placebo group (median change, +0.048 vs. -0.103 log copies/mL; P=.036, in a post hoc analysis). There were trends toward progressive modest increases in CD4+ lymphocyte counts with GM-CSF treatment at 16 weeks (median change, +14 vs. -6 cells/mm3; P=.06) and beyond.


CONCLUSIONS
GM-CSF does not have an antiviral effect in patients with ongoing HIV replication but may increase CD4+ lymphocyte counts.
Young adult sequelae of adolescent cannabis use: an integrative analysis.

BACKGROUND
Debate continues about the consequences of adolescent cannabis use. Existing data are limited in statistical power to examine rarer outcomes and less common, heavier patterns of cannabis use than those already investigated; furthermore, evidence has a piecemeal approach to reporting of young adult sequelae. We aimed to provide a broad picture of the psychosocial sequelae of adolescent cannabis use.


METHODS
We integrated participant-level data from three large, long-running longitudinal studies from Australia and New Zealand: the Australian Temperament Project, the Christchurch Health and Development Study, and the Victorian Adolescent Health Cohort Study. We investigated the association between the maximum frequency of cannabis use before age 17 years (never, less than monthly, monthly or more, weekly or more, or daily) and seven developmental outcomes assessed up to age 30 years (high-school completion, attainment of university degree, cannabis dependence, use of other illicit drugs, suicide attempt, depression, and welfare dependence). The number of participants varied by outcome (N=2537 to N=3765).


FINDINGS
We recorded clear and consistent associations and dose-response relations between the frequency of adolescent cannabis use and all adverse young adult outcomes. After covariate adjustment, compared with individuals who had never used cannabis, those who were daily users before age 17 years had clear reductions in the odds of high-school completion (adjusted odds ratio 0·37, 95% CI 0·20-0·66) and degree attainment (0·38, 0·22-0·66), and substantially increased odds of later cannabis dependence (17·95, 9·44-34·12), use of other illicit drugs (7·80, 4·46-13·63), and suicide attempt (6·83, 2·04-22·90).


INTERPRETATION
Adverse sequelae of adolescent cannabis use are wide ranging and extend into young adulthood. Prevention or delay of cannabis use in adolescence is likely to have broad health and social benefits. Efforts to reform cannabis legislation should be carefully assessed to ensure they reduce adolescent cannabis use and prevent potentially adverse developmental effects.


FUNDING
Australian Government National Health and Medical Research Council.
Hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone and highly active antiretroviral therapy for patients with acquired immunodeficiency syndrome-related Burkitt lymphoma/leukemia.

BACKGROUND
Patients with acquired immunodeficiency syndrome (AIDS)-associated lymphoma/leukemia have a poor prognosis and are frequently treated with low-intensity therapy. The authors investigated the feasibility and efficacy of hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (hyper-CVAD), a dose-intensive chemotherapy regimen, in patients with AIDS-associated Burkitt lymphoma/leukemia, as well as the possible impact of highly active antiretroviral therapy (HAART) in these patients.


METHODS
Thirteen patients with AIDS-associated Burkitt lymphoma (six patients) or leukemia (acute lymphoblastic leukemia; seven patients) were treated with hyper-CVAD alternating with high-dose methotrexate and ara-C for a total of eight cycles. Nine patients received HAART from the start of induction chemotherapy (seven patients) or later in the course of chemotherapy (two patients). The median patient age was 43 years (range, 32-55). Nine patients were diagnosed with human immunodeficiency virus (HIV) infection at the time of diagnosis of Burkitt lymphoma/leukemia; the other 4 patients had been diagnosed with HIV infection for a median of 37 months (range, 18-137) prior to the diagnosis of Burkitt lymphoma/leukemia. The median absolute CD4 count from the 9 patients with evaluable counts was 77 cells/microL (range, 9-544); only one patient had a count > 200/microL.


RESULTS
Twelve patients (92%) achieved a complete remission (CR) and one achieved a partial response (PR). Eight patients continued in CR after a median of 31 months (range, 7-45) at the time of writing. Five patients were alive and in CR over two years later. The median survival was 12 months, with 48% of patients alive after 2 years. Six of seven patients who received HAART from the start of chemotherapy were alive and in CR after a median of 29 months (range, 7-45). The four patients who did not receive HAART died. The regimen was universally myelosuppressive, but the toxicity profiles, recoveries from myelosuppression, and incidences of infectious complications were similar to that of non-HIV patients with Burkitt lymphoma/leukemia treated with the same regimen.


CONCLUSIONS
Hyper-CVAD is an effective regimen for patients with AIDS-associated Burkitt lymphoma/leukemia, with acceptable toxicity. The combination of hyper-CVAD and HAART is associated with long-term survival in patients with the two diseases, which, until recently, were both considered invariably fatal and almost futile to treat medically.
Seedling ecology of two miombo woodland trees

The development of seedlings of two miombo trees, Brachystegia spiciformis Benth. and Julbernardia paniculata (Benth.) Troupin, was studied during two growing seasons (December 1989–April 1991) at a Zambian grassland site. Seed germination rates under laboratory and field conditions were not significantly different although germination in the field was delayed by 1–2 weeks due to insufficient rainfall. After one year of storage J. paniculata seed germination had declined from 67% to 17% while germination of B. spiciformis seeds remained at about 83%. Leaf production was confined to the rainy season. Leaf fall occurred during the dry season and in J. paniculata this was followed by shoot die-back during the hot dry period (August–November). Two-thirds of B. spiciformis seedlings experienced shoot die-back but shoot die-back did not necessarily result in seedling mortality. Seedling deaths occurred during the germination period (6–10 weeks after planting) and in the hot dry period (40–50 weeks after planting) during September–November. Survivorship of B. spiciformis seedlings was 74% at the end of the second growing season while this was 46% for J. paniculata. Shoot growth was negligible during the second growing season. In fact mean maximum leaf area of B. spiciformis decreased significantly from 19.7 cm2 (SD=5.7) per plant at the end of the first growing season to 13.3 cm2 (SD=5.8) at the end of the second growing season (t=3.31, P<0.01). However, root biomass of B. spiciformis seedlings increased 2.8 times during the second growing season. These results suggest that shoot die-back in seedlings of miombo trees is caused by drought and that the slow shoot growth is the result of allocating most of the biomass to root growth during seedling development.
Measuring the performance of VoIP over Wireless LAN

IEEE 802.11 wireless local area network (WLAN) has become popular and has been providing excellent solution for wireless networking. With the popularity of WLAN and Voice over the Internet (VoIP) protocol, it is very essential to measure the performance of the VoIP over WLAN. The main goal of this paper is to compare the performance of the Voice over IP protocol in both LAN (802.3) and WLAN (802.11). This paper examines how this communication protocol performs in two different network setups and analyzes the results obtained using OPNET modeler. It also examines the optimization of 802.11e for Quality of Service (QoS) using the priorities to provide real-time service for voice over the Internet protocol.
Text-message Reminders in Colorectal Cancer Screening (TRICCS): a randomised
controlled trial

Background:We investigated the effectiveness of a text-message reminder to improve uptake of the English Bowel Cancer Screening programme in London.Methods:We performed a randomised controlled trial across 141 general practices in London. Eight thousand two hundred sixty-nine screening-eligible adults (aged 60–74 years) were randomised in a 1 : 1 ratio to receive either a text-message reminder (n=4134) or no text-message reminder (n=4135) if they had not returned their faecal occult blood test kit within 8 weeks of initial invitation. The primary outcome was the proportion of adults returning a test kit at the end of an 18-week screening episode (intention-to-treat analysis). A subgroup analysis was conducted for individuals receiving an invitation for the first time.Results:Uptake was 39.9% in the control group and 40.5% in the intervention group. Uptake did not differ significantly between groups for the whole study population of older adults (adjusted odds ratio (OR) 1.03, 95% confidence interval (CI) 0.94–1.12; P=0.56) but did vary between the groups for first-time invitees (uptake was 34.9% in the control and 40.5% in the intervention; adjusted OR 1.29, 95% CI 1.04–1.58; P=0.02).Conclusions:Although text-message reminders did not significantly increase uptake of the overall population, the improvement among first-time invitees is encouraging.
CT angiography with three-dimensional techniques for the early diagnosis of intracranial aneurysms. Comparison with intra-arterial DSA and the surgical findings.

INTRODUCTION
Cerebral CT angiography (CTA) is an established method applied to both the detection and treatment planning of intracranial aneurysms. The aim of our study was to compare CTA and digital subtraction angiography (DSA) findings with the surgical results mainly in patients with acute SAH and to evaluate the clinical usefulness of CTA.


MATERIALS AND METHODS
During the last 2 years, 82 consecutive patients were admitted under clinical symptoms and signs suggestive of harboring an intracranial aneurysm. CT angiography performed immediately afterwards the plain CT, while DSA was performed within the first 48 h of admission. All aneurysms detected were confirmed during surgery or endovascular embolization. Repeat DSA was performed in all patients having both the initial CTA and the DSA 15 days after the onset of symptoms negative. CT angiograms and conventional angiographies were studied by a consensus of two radiologists for each technique, who performed aneurysm detection, morphological features characterization and evaluation of the technique.


RESULTS
Surgical or/and endovascular treatment was performed in 45 patients and 53 aneurysms were confirmed. Using 3D-CT angiography, we detected 47 aneurysms in 42 patients. Conventional angiography depicted 43 aneurysms in 39 patients. The sensitivity of CTA for the detection of all aneurysms versus surgery was 88.7%, the specificity 100%, the positive predictive value (PPV) 100%, the negative predictive value (NPV) 80.7% and the accuracy 92.3%. Accordingly, the sensitivity of DSA was 87.8%, the specificity 98%, the PPV 97.7%, the NPV 89.1% and the accuracy 92.9%. Considering aneurysms > or =3 mm, CTA showed a sensitivity ranging from 93.3 to 100%, equal to that of DSA.


CONCLUSION
Cerebral CT angiography has an equal sensitivity to DSA in the detection of intracranial aneurysms >3 mm. It has also 100% detection rate in AcoA and MCA bifurcation aneurysms, while some locations, like posterior communicating artery aneurysms, remain problematic. The delineating features of each aneurysm are better depicted with CTA due to 3D visualization. The use of digital subtraction angiography as a diagnostic tool can be limited in equivocal cases.
Validation of an UPLC-MS/MS method for quantitative analysis of raltegravir in human plasma samples.

BACKGROUND
An ultra-performance liquid chromatography-tandem mass spectrometry method was developed for the quantification of raltegravir (RTG) plasma concentrations in samples from HIV patients treated with the drug.


METHODS
Plasma samples were extracted by liquid-liquid extraction followed by evaporation to dryness and reconstitution in mobile phase. The chromatographic separation was carried out on an AQUITY UPLC C18 column with an isocratic mobile phase consisting of water containing 0.1% formic acid and acetonitrile containing 0.1% formic acid (50:50 vol/vol). The detection was performed on a triple quadrupole tandem mass spectrometer using multi-reaction monitoring via electrospray ionization source with positive ionization mode.


RESULTS
Under these conditions, a single chromatographic run could be completed within 1 minute. The method was validated by estimating the precision and the accuracy for inter- and intra-day analysis in the concentration range of 5-2560 ng/mL. The method was linear over the investigated range with all the correlation coefficients, r, greater than 0.995 on 5 replicates. The intra- and inter-day precision (percentage of coefficient of variation) ranged from 2.4% to 11.2%, and the inaccuracy (percent of relative standard deviation) ranged from 2.5% to 12.9%. No significant matrix effect was observed. The mean recovery value of RTG was 80%.


CONCLUSIONS
This rapid and sensitive method was validated and could be applied to pharmacokinetic studies for the determination of RTG concentrations in human plasma samples.
A framework of supply chain management literature

Over the past decade, the traditional purchasing and logistics functions have evolved into a broader strategic approach to materials and distribution management known as supply chain management. This research reviews the literature base and development of supply chain management from two separate paths that eventually merged into the modern era of a holistic and strategic approach to operations, materials and logistics management. In addition, this article attempts to clearly describe supply chain management since the literature is replete with buzzwords that address elements or stages of this new management philosophy. This article also discusses various supply chain management strategies and the conditions conducive to supply chain management. ( 2000 Elsevier Science Ltd. All rights reserved.
A proportional share resource allocation algorithm for real-time, time-shared systems

We propose and analyze a proportional share resource allocation algorithm for realizing real-time performance in time-shared operating systems. Processes are assigned a weight which determines a share (percentage) of the resource they are to receive. The resource is then allocated in discrete-sized time quanta in such a manner that each process makes progress at a precise, uniform rate. Proportional share allocation algorithms are of interest because (1) they provide a natural means of seamlessly integrating realand nonreal-time processing, (2) they are easy to implement, (3) they provide a simple and e ective means of precisely controlling the real-time performance of a process, and (4) they provide a natural mean of policing so that processes that use more of a resource than they request have no ill-e ect on well-behaved processes. We analyze our algorithm in the context of an idealized system in which a resource is assumed to be granted in arbitrarily small intervals of time and show that our algorithm guarantees that the di erence between the service time that a process should receive in the idealized system and the service time it actually receives in the real system is optimally bounded by the size of a Supported by GAANN fellowship. Dept. of CS, Old Dominion Univ., Norfolk, VA 23529-0162 (stoica@cs.odu.edu). ySupported by NSF grant CCR 95{9313857. Dept. of CS, Old Dominion Univ., Norfolk, VA 23529-0162 (wahab@cs.odu.edu). zSupported by grant from the IBM & Intel corps and NSF grant CCR 95{10156. Dpt. of CS, Univ. of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3175, (jeffay@cs.unc.edu). xSupported by NSF under Research Initiation Award CCR{ 9596282. Dept. of CS, Univ. of Vermont, Burlignton, VT 05405, (sanjoy@cs.uvm.edu). {Dpt. of CS, Univ. of Wisconsin-Madison, Madison, WI 53706-1685 (johannes@cs.wisc.edu). kSupported by NSF grant CCR{9504145, and the Texas Advanced Research Program under grant No. ARP{93{00365{461. Dpt. of CS, Univ. of Texas at Austin, Austin, TX 78712-1188 (plaxton@cs.utexas.edu). time quantum. In addition, the algorithm provides support for dynamic operations, such as processes joining or leaving the competition, and for both fractional and non-uniform time quanta. As a proof of concept we have implemented a prototype of a CPU scheduler under FreeBSD. The experimental results shows that our implementation performs within the theoretical bounds and hence supports real-time execution in a general purpose operating system.