LLukas22/scidocs huggingface dataset:
Changing core beliefs with trial-based cognitive therapy may improve quality of life in social phobia: a randomized study.

OBJECTIVE
To determine whether there are differences in quality of life (QoL) improvement after treatment with the trial-based thought record (TBTR) versus conventional cognitive therapy (CCT) in patients with social anxiety disorder (SAD).


METHOD
A randomized trial comparing TBTR with a set of CCT techniques, which included the standard 7-column dysfunctional thought record (DTR) and the positive data log (PDL) in patients with SAD, generalized type.


RESULTS
Repeated measures analysis of variance (ANOVA) revealed a significant time effect in the general health, vitality, social functioning, and mental health domains of the Short Form 36. It also indicated significant treatment effects on the bodily pain, social functioning, role-emotional, and mental health domains, with higher scores in the TBTR group. One-way analysis of covariance (ANCOVA), using pretreatment values as covariates, showed that TBTR was associated with significantly better QoL post-treatment (bodily pain, social functioning and role-emotional) and at follow-up (role-emotional). A significant treatment effect on the role-emotional domain at 12-month follow-up denoted a sustained effect of TBTR relative to CCT.


CONCLUSION
This study provided preliminary evidence that TBTR is at least as effective as CCT in improving several domains of QoL in SAD, specifically when the standard 7-column DTR and the PDL are used.
Predicting chest wall pain from lung stereotactic body radiotherapy for different fractionation schemes.

PURPOSE
Recent studies with two fractionation schemes predicted that the volume of chest wall receiving >30 Gy (V30) correlated with chest wall pain after stereotactic body radiation therapy (SBRT) to the lung. This study developed a predictive model of chest wall pain incorporating radiobiologic effects, using clinical data from four distinct SBRT fractionation schemes.


METHODS AND MATERIALS
102 SBRT patients were treated with four different fractionations: 60 Gy in three fractions, 50 Gy in five fractions, 48 Gy in four fractions, and 50 Gy in 10 fractions. To account for radiobiologic effects, a modified equivalent uniform dose (mEUD) model calculated the dose to the chest wall with volume weighting. For comparison, V30 and maximum point dose were also reported. Using univariable logistic regression, the association of radiation dose and clinical variables with chest wall pain was assessed by uncertainty coefficient (U) and C statistic (C) of receiver operator curve. The significant associations from the univariable model were verified with a multivariable model.


RESULTS
106 lesions in 102 patients with a mean age of 72 were included, with a mean of 25.5 (range, 12-55) months of follow-up. Twenty patients reported chest wall pain at a mean time of 8.1 (95% confidence interval, 6.3-9.8) months after treatment. The mEUD models, V30, and maximum point dose were significant predictors of chest wall pain (p < 0.0005). mEUD improved prediction of chest wall pain compared with V30 (C = 0.79 vs. 0.77 and U = 0.16 vs. 0.11). The mEUD with moderate weighting (a = 5) better predicted chest wall pain than did mEUD without weighting (a = 1) (C = 0.79 vs. 0.77 and U = 0.16 vs. 0.14). Body mass index (BMI) was significantly associated with chest wall pain (p = 0.008). On multivariable analysis, mEUD and BMI remained significant predictors of chest wall pain (p = 0.0003 and 0.03, respectively).


CONCLUSION
mEUD with moderate weighting better predicted chest wall pain than did V30, indicating that a small chest wall volume receiving a high radiation dose is responsible for chest wall pain. Independently of dose to the chest wall, BMI also correlated with chest wall pain.
Construction of uninorms on bounded lattices

Karaçal and Mesiar showed that it is possible to construct uninorms on an arbitrary bounded lattice. Particularly, they constructed the weakest and the strongest uninorm. In this paper another method for a construction of uninorms on bounded lattices is proposed. The cases of general bounded lattices as well as bounded lattices equipped with a special arithmetic operation, are discussed.
Flowshop-scheduling problems with makespan criterion: a review

This paper is a complete survey of flowshop-scheduling problems and contributions from early works of Johnson of 1954 to recent approaches of metaheuristics of 2004. It mainly considers a flowshop problem with a makespan criterion and it surveys some exact methods (for small size problems), constructive heuristics and developed improving metaheuristic and evolutionary approaches as well as some well-known properties and rules for this problem. Each part has a brief literature review of the contributions and a glimpse of that approach before discussing the implementation for a flowshop problem. Moreover, in the first section, a complete literature review of flowshop-related scheduling problems with different assumptions as well as contributions in solving these other aspects is considered. This paper can be seen as a reference to past contributions (particularly in n/m/ p/cmax or equivalently F/prmu/cmax) for future research needs of improving and developing better approaches to flowshop-related scheduling problems.
Changes in supportive care needs after first-line treatment for ovarian cancer: identifying care priorities and risk factors for future unmet needs.

OBJECTIVE
The objective of this paper is to determine changes in supportive care needs after first-line treatment for ovarian cancer and identify risk factors for future unmet needs.


METHODS
Two hundred and nineteen women with ovarian cancer were asked to complete a baseline survey 6-12 months after diagnosis then follow-up surveys every 6 months for up to 2 years. The validated Supportive Care Needs Survey-Short Form measured 34 needs across five domains. Logistic regression identified baseline variables associated with future needs.


RESULTS
At baseline, standardized median scores (possible range 0-100, least-to-greatest need) within the psychological, system/information, physical, patient care and sexuality need domains were 25, 20, 15, 15 and 8, respectively. The most frequently reported moderate-to-high unmet needs at baseline were needing help with fear about cancer spreading (25%), concerns about worries of those close (20%), being informed about things to help get well (20%), uncertainty about future (19%) and lack of energy (18%). All except the item about being informed were still reported as unmet needs by ≥ 15% of women 2 years later. Median health system/information, patient care and sexuality need scores decreased over 2 years (p<0.05), whereas psychological and physical scores remained constant. Risk factors for having ≥ 1 moderate-to-high unmet overall, psychological or physical need 1-2 years after baseline included older age, advanced disease, unmet need, anxiety, depression, insomnia and less social support at baseline.


CONCLUSION
Women with ovarian cancer report needing ongoing assistance to deal with psychological and physical needs over the first 2 years after first-line treatment. Targeting individuals at risk of future unmet needs should be prioritized.
Effect of zirconia surface treatments on the shear bond strength of veneering ceramic

ABSTARCT Background: The aim of the study was to investigate the effect of surface treatments of zirconia (grinding and sandblast with 50μm, 100 μm) on shear bond strength between zirconia core and veneering ceramic. Material and methods: Twenty-eight presintered Y-TZP ceramic specimens (IPS e.max ZirCAD, Ivoclar vivadent) were fabricated and sintered according to manufacturer’s instructions. The core specimens were divided randomly in to 4 groups, group 1: no surface treatment, group2: zirconia specimens were ground with silicon carbide paper up to1200 grit under water cooling, group3: zirconia specimens were ground and sandblast with 100 μm alumina, group 4: zirconia specimens were ground and sandblast with 50 μm alumina. Surface roughness of specimens were analyzed by surface profilometer, then veneering ceramic (IPS e.max ceramic, Ivoclar vivadent) was applied on the specimens& fired according to manufacturer’s instructions. All specimens were subjected to shear force in a universal testing machine at a crosshead speed of 1mm/min. The shear bond strength values were analyzed with one-way ANOVA; the fractured surfaces were examined with a stereo-microscope to observe the failure mode. Results: The mean of shear bond strength values in MPa were 24.75 for group 4, (17.72) for group 3, (17.68) for group2, (14.61) for group 1.The airborne-particle abrasion with 50μm group showed significantly higher bond strength than other groups. The airborne-particle-abraded with 100 μm group was not significantly different from grinding group. Conclusion: With limit of this study, the sandblast with 50 μm alumina was enhance the SBS between zirconia &veneering ceramic, and zirconia-veneering ceramic bonding is not only influenced by surface roughness. But also may be other factors.
Multiple intravenous infusions phase 1b: practice and training scan.

BACKGROUND
Minimal research has been conducted into the potential patient safety issues related to administering multiple intravenous (IV) infusions to a single patient. Previous research has highlighted that there are a number of related safety risks. In Phase 1a of this study, an analysis of 2 national incident-reporting databases (Institute for Safe Medical Practices Canada and United States Food and Drug Administration MAUDE) found that a high percentage of incidents associated with the administration of multiple IV infusions resulted in patient harm.


OBJECTIVES
The primary objectives of Phase 1b of this study were to identify safety issues with the potential to cause patient harm stemming from the administration of multiple IV infusions; and to identify how nurses are being educated on key principles required to safely administer multiple IV infusions.


DATA SOURCES AND REVIEW METHODS
A field study was conducted at 12 hospital clinical units (sites) across Ontario, and telephone interviews were conducted with program coordinators or instructors from both the Ontario baccalaureate nursing degree programs and the Ontario postgraduate Critical Care Nursing Certificate programs. Data were analyzed using Rasmussen's 1997 Risk Management Framework and a Health Care Failure Modes and Effects Analysis.


RESULTS
Twenty-two primary patient safety issues were identified with the potential to directly cause patient harm. Seventeen of these (critical issues) were categorized into 6 themes. A cause-consequence tree was established to outline all possible contributing factors for each critical issue. Clinical recommendations were identified for immediate distribution to, and implementation by, Ontario hospitals. Future investigation efforts were planned for Phase 2 of the study.


LIMITATIONS
This exploratory field study identifies the potential for errors, but does not describe the direct observation of such errors, except in a few cases where errors were observed. Not all issues are known in advance, and the frequency of errors is too low to be observed in the time allotted and with the limited sample of observations.


CONCLUSIONS
The administration of multiple IV infusions to a single patient is a complex task with many potential associated patient safety risks. Improvements to infusion and infusion-related technology, education standards, clinical best practice guidelines, hospital policies, and unit work practices are required to reduce the risk potential. This report makes several recommendations to Ontario hospitals so that they can develop an awareness of the issues highlighted in this report and minimize some of the risks. Further investigation of mitigating strategies is required and will be undertaken in Phase 2 of this research.
Serum interleukin-17 levels are associated with nephritis in childhood-onset systemic lupus erythematosus

OBJECTIVES
To determine the serum interleukin-17 (IL-17) levels in childhood-onset systemic lupus erythematosus patients and to evaluate the association between IL-17 and clinical manifestations, disease activity, laboratory findings and treatment.


METHODS
We included 67 consecutive childhood-onset systemic lupus erythematosus patients [61 women; median age 18 years (range 11-31)], 55 first-degree relatives [50 women; median age 40 years (range 29-52)] and 47 age- and sex-matched healthy controls [42 women; median age 19 years (range 6-30)]. The childhood-onset systemic lupus erythematosus patients were assessed for clinical and laboratory systemic lupus erythematosus manifestations, disease activity [Systemic Lupus Erythematosus Disease Activity Index (SLEDAI)], cumulative damage [Systemic Lupus International Collaborating Clinics/American College of Rheumatology (ACR) Damage Index] and current drug use. Serum IL-17 levels were measured by an enzyme-linked immunosorbent assay using commercial kits.


RESULTS
The median serum IL-17 level was 36.3 (range 17.36-105.92) pg/mL in childhood-onset systemic lupus erythematosus patients and 29.47 (15.16-62.17) pg/mL in healthy controls (p=0.009). We observed an association between serum IL-17 levels and active nephritis (p=0.01) and migraines (p=0.03). Serum IL-17 levels were not associated with disease activity (p=0.32), cumulative damage (p=0.34), or medication use (p=0.63).


CONCLUSION
IL-17 is increased in childhood-onset systemic lupus erythematosus and may play a role in the pathogenesis of neuropsychiatric and renal manifestations. Longitudinal studies are necessary to determine the role of IL-17 in childhood-onset systemic lupus erythematosus.
Short-term intravenous therapy with Neridronate in Paget's disease.

AIMS
To describe the effects of two consecutive intravenous infusions of aminohexane bisphosphonate (Neridronate) in patients with active Paget's disease of bone.


METHODS
The study population included 83 patients, aged 41 to 85 years, randomized to 4 cumulative doses of Neridronate (25, 50, 100, 200 mg) given over 2 days, with a follow up of 180 days. The baseline serum alkaline phosphatase activity was at least 10% above the upper limit of the laboratory range. The response to treatment was assessed by changes in the serum total alkaline phosphatase (primary end point of the study), bone alkaline phosphatase and N-telopeptide urinary excretion.


RESULTS
All Neridronate doses significantly suppressed the biochemical indices of disease activity. The nadir of total alkaline phosphatase levels ranged from -16 % to -57.5% of pretreatment values in the four groups, with a dose-response relationship that was apparent even between the two highest doses. The proportion of patients still maintaining a partial response (decreases in serum total alkaline phosphatase >25%) at the 6 month follow-up was also related to the dose: 98%, 67%, 57%, 21% in the patients given 200, 100, 50, 25 mg respectively. The proportion of responders in terms of bone alkaline phosphatase and N-telopeptide excretion changes was similar. Bone pain attributed to Paget's disease was significantly reduced. A typical acute phase reaction (fever and/or arthromyalgia) occurred in 16 out of 83 patients.


CONCLUSIONS
We conclude that all of the Neridronate doses tested here were well tolerated and effective in decreasing, in a dose-related manner the bone turnover parameters of Paget's disease. The highest dose (200 mg) resulted in the normalization of the markers of disease activity in more than 60% of the patients.
Metastable structures of splat-cooled and vapour- depodited lead and antimony films

Abstract An apparatus for splat quenching in a vacuum and in controlling ambients by the “gun” technique was set up and a cooling rate of approximately 10 8 K s −1 was achieved. Splat-quenched lead foils exhibit an h.c.p. structure which transforms to the equilibrium f.c.c. structure at temperatures above 270°C and corresponds to the high pressure phase of lead. Antimony foils prepared by splat quenching show the existence of simple cubic, f.c.c. tetragonal and distorted rhombohedral metastable structures. The metastable rhombohedral phase tranforms to the equilibrium rhombohedral phase on heating while the simple cubic, f.c.c. and tetragonal phases transform to an h.c.p. structure. The simple cubic and h.c.p. phases correspond to the known high pressure phases of antimony. Films prepared by vapour deposition at room temperature show the same metastable f.c.c. and rhombohedral phases as those observed in splat-quenched foils. Antimony films deposited at liquid air temperatures are amorphous. No metastable structure was observed in lead films quenched from the vapour under similar conditions.
Study protocol for a randomized controlled trial of humor therapy in residential care: the Sydney Multisite Intervention of LaughterBosses and ElderClowns (SMILE).

BACKGROUND
Humor therapy is a non-pharmacological intervention with potential to improve mood and quality of life for institutionalized older persons, including those with dementia. The primary aims of the Sydney Multisite Intervention of LaughterBosses and ElderClowns (SMILE) are to examine the effects of humor therapy on residents' mood, quality of life, social engagement, and agitation.


METHODS
SMILE is a single-blinded cluster-randomized controlled trial where 398 consented residents in 35 residential aged care facilities will be allocated to receive humor therapy or usual care. Residents allocated to the intervention group will engage in humor therapy with professional performers (ElderClowns) and trained facility staff (LaughterBosses) for a minimum of nine two-hour sessions over 12 weeks as well as engaging humorously with LaughterBosses during the course of daily care. The usual care control group will not engage in any formal humor therapy. Researchers, blind to treatment allocation, will assess residents at baseline (week 0), post-intervention (week 13), and follow-up (week 26). The measurement suite includes the Cornell Scale for Depression in Dementia, the Dementia Quality of Life Scale, the Multidimensional Observation Scale for Elderly Subjects, the Cohen-Mansfield Agitation Inventory, and the Neuropsychiatric Inventory. Observations of residents' engagement will be recorded at each humor therapy session.


CONCLUSIONS
SMILE is the first large rigorous study of humor therapy in aged care.
Updates in Cardiac Amyloidosis: A Review

S ystemic amyloidosis is a relatively rare multisystem disease caused by the deposition of misfolded protein in various tissues and organs. It may present to almost any specialty, and diagnosis is frequently delayed.1 Cardiac involvement is a leading cause of morbidity and mortality, especially in primary light chain (AL) amyloidosis and in both wild-type and hereditary transthyretin amyloidosis. The heart is also occasionally involved in acquired serum amyloid A type (AA) amyloidosis and other rare hereditary types. Clinical phenotype varies greatly between different types of amyloidosis, and even the cardiac presentation has a great spectrum. The incidence of amyloidosis is uncertain, but it is thought that the most frequently diagnosed AL amyloidosis has an annual incidence of 6 to 10 cases per million population in the United Kingdom and United States. Amyloidosis due to transthyretin deposition (ATTR) can be wild-type transthyretin amyloid deposits, which predominantly accumulate in the heart and are very common at autopsy in the elderly. Although the associated clinical syndrome known as senile systemic amyloidosis is diagnosed rarely in life,2 there is increasing evidence that this disorder is much underdiagnosed and that with increasing longevity and improved diagnostic methods it may be identified as a substantial public health problem. This review focuses on recent progress in the field: novel diagnostic and surveillance approaches using imaging (echocardiography, cardiovascular magnetic resonance), biomarkers (brain natriuretic peptide [BNP], high-sensitivity troponin), new histological typing techniques, and current and future treatments, including approaches directly targeting the amyloid deposits.3
Migrate or not? Exploring virtual machine migration in roadside cloudlet-based vehicular cloud

Vehicle Ad-Hoc Networks (VANET) enable all components in intelligent transportation systems to be connected so as to improve transport safety, relieve traffic congestion, reduce air pollution, and enhance driving comfort. The vision of all vehicles connected poses a significant challenge to the collection, storage, and analysis of big traffic-related data. Vehicular cloud computing, which incorporates cloud computing into vehicular networks, emerges as a promising solution. Different from conventional cloud computing platform, the vehicle mobility poses new challenges to the allocation and management of cloud resources in roadside cloudlet. In this paper, we study a virtual machine (VM) migration problem in roadside cloudletbased vehicular network and unfold that (1) whether a VM shall be migrated or not along with the vehicle moving and (2) where a VM shall be migrated, in order to minimize the overall network cost for both VM migration and normal data traffic. We first treat the problem as a static off-line VM placement problem and formulate it into a mixed-integer quadratic programming problem. A heuristic algorithm with polynomial time is then proposed to tackle the complexity of solving mixed-integer quadratic programming. Extensive simulation results show that it produces near-optimal performance and outperforms other related algorithms significantly. Copyright © 2015 John Wiley & Sons, Ltd.
A data mining approach to guide students through the enrollment process based on academic performance

Student academic performance at universities is crucial for education management systems. Many actions and decisions are made based on it, specifically the enrollment process. During enrollment, students have to decide which courses to sign up for. This research presents the rationale behind the design of a recommender system to support the enrollment process using the students’ academic performance record. To build this system, the CRISP-DM methodology was applied to data from students of the Computer Science Department at University of Lima, Perú. One of the main contributions of this work is the use of two synthetic attributes to improve the relevance of the recommendations made. The first attribute estimates the inherent difficulty of a given course. The second attribute, named potential, is a measure of the competence of a student for a given course based on the grades obtained in related courses. Data was mined using C4.5, KNN (K-nearest neighbor), Naïve Bayes, Bagging and Boosting, and a set of experiments was developed in order to determine the best algorithm for this application domain. Results indicate that Bagging is the best method regarding predictive accuracy. Based on these results, the “Student Performance Recommender System” (SPRS) was developed, including a learning engine. SPRS was tested with a sample group of 39 students during the enrollment process. Results showed that the system had a very good performance under real-life conditions.