LLukas22/scidocs huggingface dataset:
Effect of barcode-assisted medication administration on emergency department medication errors.

OBJECTIVES
Barcode-assisted medication administration (BCMA) is technology with demonstrated benefit in reducing medication administration errors in hospitalized patients; however, it is not routinely used in emergency departments (EDs). EDs may benefit from BCMA, because ED medication administration is complex and error-prone.


METHODS
A naïve observational study was conducted at an academic medical center implementing BCMA in the ED. The rate of medication administration errors was measured before and after implementing an integrated electronic medical record (EMR) with BCMA capacity. Errors were classified as wrong drug, wrong dose, wrong route of administration, or a medication administration with no physician order. The error type, severity of error, and medications associated with errors were also quantified.


RESULTS
A total of 1,978 medication administrations were observed (996 pre-BCMA and 982 post-BCMA). The baseline medication administration error rate was 6.3%, with wrong dose errors representing 66.7% of observed errors. BCMA was associated with a reduction in the medication administration error rate to 1.2%, a relative rate reduction of 80.7% (p < 0.0001). Wrong dose errors decreased by 90.4% (p < 0.0001), and medication administrations with no physician order decreased by 72.4% (p = 0.057). Most errors discovered were of minor severity. Antihistamine medications were associated with the highest error rate.


CONCLUSIONS
Implementing BCMA in the ED was associated with significant reductions in the medication administration error rate and specifically wrong dose errors. The results of this study suggest a benefit of BCMA on reducing medication administration errors in the ED.
Named entity recognition for tweets

Two main challenges of Named Entity Recognition (NER) for tweets are the insufficient information in a tweet and the lack of training data. We propose a novel method consisting of three core elements: (1) normalization of tweets; (2) combination of a K-Nearest Neighbors (KNN) classifier with a linear Conditional Random Fields (CRF) model; and (3) semisupervised learning framework. The tweet normalization preprocessing corrects common ill-formed words using a global linear model. The KNN-based classifier conducts prelabeling to collect global coarse evidence across tweets while the CRF model conducts sequential labeling to capture fine-grained information encoded in a tweet. The semisupervised learning plus the gazetteers alleviate the lack of training data. Extensive experiments show the advantages of our method over the baselines as well as the effectiveness of normalization, KNN, and semisupervised learning.
Vancomycin dosing in morbidly obese patients

Objectives and methods: Vancomycin hydrochloride dosing requirements in morbidly obese patients with normal renal function were computed to determine the dose of vancomycin necessary to achieve target steady-state peak and trough concentrations and compared with a normal weight population. Results: Morbidly obese patients [total body weight (TBW) 165 kg, ideal body weight (IBW) 63 kg] required 31.2 mg · kg−1 · d−1 TBW or 81.9 mg · kg−1 · d−1 IBW to achieve the target concentrations. Normal weight patients (TBW 68.6 kg) required 27.8 mg · kg−1 · d−1 to achieve the same concentrations. Because of altered kinetic parameters in the morbidly obese patients (obese: t1/2=3.3 h, V=52 l, CL =197 ml · min−1; normal: t1/2=7.2 h, V=46 l, CL=77 ml · min−1, 20 of 24 patients required q8h dosing (1938 mg q8h) compared with q12h dosing (954 mg q12h) in all normal weight patients in order to avoid trough concentrations that were too low for prolonged periods. There was a good correlation between TBW and CL, but only fair correlation between TBW and V. Conclusion: Doses required to achieve desired vancomycin concentrations are similar in morbidly obese and normal weight patients when TBW is used as a dosing weight for the obese (approximately 30 mg · kg−1 · d−1). Shorter dosage intervals may be needed when dosing morbidly obese patients so that steady-state trough concentrations remain above 5 μg · ml−1 in this population. Because of the large amount of variation in required doses, vancomycin serum concentrations should be obtained in morbidly obese patients to ensure that adequate doses are being administered. Dosage requirements for morbidly obese patients with renal dysfunction require further study.
"Teaching as a Competency": competencies for medical educators.

Most medical faculty receive little or no training about how to be effective teachers, even when they assume major educational leadership roles. To identify the competencies required of an effective teacher in medical education, the authors developed a comprehensive conceptual model. After conducting a literature search, the authors met at a two-day conference (2006) with 16 medical and nonmedical educators from 10 different U.S. and Canadian organizations and developed an initial draft of the "Teaching as a Competency" conceptual model. Conference participants used the physician competencies (from the Accreditation Council for Graduate Medical Education [ACGME]) and the roles (from the Royal College's Canadian Medical Education Directives for Specialists [CanMEDS]) to define critical skills for medical educators. The authors then refined this initial framework through national/regional conference presentations (2007, 2008), an additional literature review, and expert input. Four core values grounded this framework: learner engagement, learner-centeredness, adaptability, and self-reflection. The authors identified six core competencies, based on the ACGME competencies framework: medical (or content) knowledge; learner- centeredness; interpersonal and communication skills; professionalism and role modeling; practice-based reflection; and systems-based practice. They also included four specialized competencies for educators with additional programmatic roles: program design/implementation, evaluation/scholarship, leadership, and mentorship. The authors then cross-referenced the competencies with educator roles, drawing from CanMEDS, to recognize role-specific skills. The authors have explored their framework's strengths, limitations, and applications, which include targeted faculty development, evaluation, and resource allocation. The Teaching as a Competency framework promotes a culture of effective teaching and learning.
Physician Perspectives on Medical Home Recognition for Practice Transformation for Children.

OBJECTIVE
To examine child-serving physicians' perspectives on motivations for and support for practices in seeking patient-centered medical home (PCMH) recognition, changes in practice infrastructure, and care processes before and after recognition, and perceived benefits and challenges of functioning as a PCMH for the children they serve, especially children with special health care needs.


METHODS
Semistructured interviews with 20 pediatricians and family physicians at practices that achieved National Committee for Quality Assurance level 3 PCMH recognition before 2011. We coded notes and identified themes using an iterative process and pattern recognition analysis.


RESULTS
Physicians reported being motivated to seek PCMH recognition by a combination of altruistic and practical goals. Most said recognition acknowledged existing practice characteristics, but encouraged ongoing, and in some cases substantial, transformation. Although many physicians said recognition helped practices improve financial arrangements with payers and participate in quality initiatives, most physicians could not assess the specific benefits of recognition on patients' use of services or health outcomes. Challenges for practices in providing care for children included managing additional physician responsibilities, communicating with other providers and health systems, and building sustainable care coordination procedures.


CONCLUSIONS
PCMH recognition can be valuable to practices as a public acknowledgement to payers and patients that certain processes are in place, and can also catalyze new and continued transformation. Programs and policies seeking to transform primary care for children should leverage physicians' motivations and find mechanisms to build practices' capacity for care management systems and linkages with the medical neighborhood.
Transjugular Intrahepatic Portosystemic Shunt in the Treatment of Portal Hypertension Using Memotherm Stents: A Prospective Multicenter Study

Purpose: In a prospective multicenter study, efficacy and safety of transjugular intrahepatic portosystemic shunts (TIPS) were evaluated in the treatment of the complications of portal hypertension using a new self-expanding mesh-wire stent (Memotherm). Methods: One hundred and eighty-one patients suffering from variceal bleeding (either acute or recurrent) or refractory ascites were enrolled. Postinterventional follow-up lasted for 8.4 months on average. Differences were analyzed by the log-rank test (chi-square) or Wilcoxon test. Results: Shunt insertion was completed successfully in all patients (n = 181 patients, 100%). During follow-up, shunt occlusion was evident in 23 patients, and shunt stenosis was found in 33 patients (12.7% and 18.2%, respectively). Variceal rebleeding occurred in 20 of 139 patients (14.4%), with at least one episode of bleeding before TIPS treatment. The overall mortality rate of the patients treated by TIPS was 39.8%. In 51.4% of these cases (37 of 72 patients), however, the patients died within 30 days after TIPS placement. Analysis of subgroups showed that patients who underwent emergency TIPS for acute variceal bleeding had a significantly higher early mortality compared with other patient groups (p = 0.0014). Conclusion: In the present prospective multicenter study, we were able to show that insertion of Memotherm stents is an effective tool for TIPS. The occlusion rates seem to be comparable to those reported for the Palmaz stent. It could be shown that in particular, those patients who were treated for acute bleeding were at high risk of early mortality. Consequently, in such a critical condition, the indication for TIPS has to be set carefully.
[QT interval dispersion analysis in acute myocardial infarction patients: coronary reperfusion effect].

OBJECTIVE
To study the effect of early reperfusion of infarct-related artery on QT(DeltaQT) dispersion interval, as well as how valuable it is as a marker for coronary reperfusion and ventricular arrhythmias.


METHODS
One hundred and six patients with reperfusion (WR) and 48 without reperfusion (WtR) who have received thrombolytic therapy in the acute phase of infarction were studied. ECG carried out on admission as well as on day 4 of patients course were analyzed. DeltaQT - defined as the difference between maximum and minimum QT interval - was measured by 12-lead ECG.


RESULTS
The reperfusion group showed significant DeltaQT reduction - from 89.66+/-20.47ms down to 70.95+/-21.65ms (p<0.001). On the other hand, the group without reperfusion showed DeltaQT significant increase - from 81.27+/-20.52ms up to 91.85+/-24.66ms (p<0.001). Logistic regression analysis showed that reduction magnitude between pre- and post-thrombolysis DeltaQT was the independent factor to most effectively identify coronary reperfusion (OR 1.045, p<0.0001; CI 95%). No significant difference was found in dispersion measures when patients with ventricular arrhythmias were compared with those with no arrhythmias in the course of the first 48 hours.


CONCLUSION
The study shows that DeltaQT is significantly reduced in patients with acute myocardial infarction submitted to successful thrombolysis, and is increased in infarcted patients with closed artery. DeltaQT reduction between the pre- and post-thrombolysis condition was a predictor for coronary reperfusion of those patients, and did not show correlation to ventricular arrhythmias.
Effect of cinnamon on gastric emptying, arterial stiffness, postprandial lipemia, glycemia, and appetite responses to high-fat breakfast

BACKGROUND
Cinnamon has been shown to delay gastric emptying of a high-carbohydrate meal and reduce postprandial glycemia in healthy adults. However, it is dietary fat which is implicated in the etiology and is associated with obesity, type 2 diabetes and cardiovascular disease. We aimed to determine the effect of 3 g cinnamon (Cinnamomum zeylanicum) on GE, postprandial lipemic and glycemic responses, oxidative stress, arterial stiffness, as well as appetite sensations and subsequent food intake following a high-fat meal.


METHODS
A single-blind randomized crossover study assessed nine healthy, young subjects. GE rate of a high-fat meal supplemented with 3 g cinnamon or placebo was determined using the 13C octanoic acid breath test. Breath, blood samples and subjective appetite ratings were collected in the fasted and during the 360 min postprandial period, followed by an ad libitum buffet meal. Gastric emptying and 1-day fatty acid intake relationships were also examined.


RESULTS
Cinnamon did not change gastric emptying parameters, postprandial triacylglycerol or glucose concentrations, oxidative stress, arterial function or appetite (p < 0.05). Strong relationships were evident (p < 0.05) between GE Thalf and 1-day palmitoleic acid (r = -0.78), eiconsenoic acid (r = -0.84) and total omega-3 intake (r = -0.72). The ingestion of 3 g cinnamon had no effect on GE, arterial stiffness and oxidative stress following a HF meal.


CONCLUSIONS
3 g cinnamon did not alter the postprandial response to a high-fat test meal. We find no evidence to support the use of 3 g cinnamon supplementation for the prevention or treatment of metabolic disease. Dietary fatty acid intake requires consideration in future gastrointestinal studies.


TRIAL REGISTRATION



TRIAL REGISTRATION NUMBER
at http://www.clinicaltrial.gov: NCT01350284.
Laparoscopic Transabdominal Pre-Peritoneal (TAPP) procedure - step-by-step tips and tricks.

UNLABELLED
Minimally invasive approach for groin hernia treatment is still controversial, but in the last decade, it tends to become the standard procedure for one day surgery. We present herein the technique of laparoscopic Trans Abdominal Pre Peritoneal approach (TAPP). The surgical technique is presented step-by step;the different procedures key points (e.g. anatomic landmarks recognition, diagnosis of "occult" hernias, preperitoneal and hernia sac dissection, mesh placement and peritoneal closure) are described and discussed in detail, several tips and tricks being noted and highlighted.


CONCLUSIONS
TAPP is a feasible method for treating groin hernia associated with low rate of postoperative morbidity and recurrence. The anatomic landmarks are easily recognizable. The laparoscopic exploration allows for the treatment of incarcerated strangulated hernias and the intraoperative diagnosis of occult hernias.
The Character Strengths Rating Form ( CSRF ) : Development and initial assessment of a 24-item rating scale to assess character strengths

Character strengths are morally, positively, valued traits that are related to several positive life outcomes. In this study, the Character Strengths Rating Form (CSRF), a 24-item rating form of character strengths based on the classification proposed by Peterson and Seligman (2004), was developed using the data of 211 German-speaking adults. The CSRF yielded good convergence with Peterson and Seligman’s Values in Action Inventory of Strengths (VIA-IS) in terms of descriptive statistics, relationships with socio-demographic variables, and associations with life satisfaction; the means correlated .91, and standard deviations correlated .80. Correlations between corresponding strengths in the CSRF and the VIA-IS were between .41 and .77. Rank-order correlations of the correlations of both measures with age, education, and life satisfaction were .74, .76, and .84, respectively. Factor structure congruence coefficients ranged between .92 and .99. The rank-order correlation of the associations of the 5 factors with life satisfaction was .90. The CSRF proved to be a valid instrument for the assessment of character strengths. Its use is recommended for a brief measurement of character strengths when economy of instruments is at a premium (e.g., in large-scale longitudinal studies). DOI: https://doi.org/10.1016/j.paid.2014.03.042 Posted at the Zurich Open Repository and Archive, University of Zurich ZORA URL: https://doi.org/10.5167/uzh-95983 Accepted Version Originally published at: Ruch, Willibald; Martínez-Martí, María Luisa; Proyer, Rene T; Harzer, Claudia (2014). The Character Strengths Rating Form (CSRF): Development and initial assessment of a 24-item rating scale to assess character strengths. Personality and Individual Differences, 68:53-58. DOI: https://doi.org/10.1016/j.paid.2014.03.042 This	  manuscript	  was	  published	  as: Ruch,	  W.,	  Martínez-­‐Martí,	  M.	  L.,	  Proyer,	  R.	  T.,	  &	  Harzer,	  C.	  (2014).	  The Character	  Strengths	  Rating	  Form	  (CSRF):	  Development	  and	  initial assessment	  of	  a	  24-­‐Item	  rating	  scale	  to	  assess	  character	  strengths. Personality	  and	  Individual	  Differences,	  68,	  53-­‐58. doi:10.1016/j.paid.2014.03.042 Social Indicators Research The Character Strengths Rating Form (CSRF): Development and Initial Assessment of a 24-Item Rating Scale to Assess Character Strengths --Manuscript Draft-Manuscript Number: Full Title: The Character Strengths Rating Form (CSRF): Development and Initial Assessment of a 24-Item Rating Scale to Assess Character Strengths Article Type: Original Research
Reconstruction and Simulation of Neocortical Microcircuitry

UNLABELLED
We present a first-draft digital reconstruction of the microcircuitry of somatosensory cortex of juvenile rat. The reconstruction uses cellular and synaptic organizing principles to algorithmically reconstruct detailed anatomy and physiology from sparse experimental data. An objective anatomical method defines a neocortical volume of 0.29 ± 0.01 mm(3) containing ~31,000 neurons, and patch-clamp studies identify 55 layer-specific morphological and 207 morpho-electrical neuron subtypes. When digitally reconstructed neurons are positioned in the volume and synapse formation is restricted to biological bouton densities and numbers of synapses per connection, their overlapping arbors form ~8 million connections with ~37 million synapses. Simulations reproduce an array of in vitro and in vivo experiments without parameter tuning. Additionally, we find a spectrum of network states with a sharp transition from synchronous to asynchronous activity, modulated by physiological mechanisms. The spectrum of network states, dynamically reconfigured around this transition, supports diverse information processing strategies.


PAPERCLIP
VIDEO ABSTRACT.
My Computer Is an Honor Student - but How Intelligent Is It? Standardized Tests as a Measure of AI

tion can machines think? by replacing it with another, namely can a machine pass the imitation game (the Turing test). In the years since, this test has been criticized as being a poor replacement for the original enquiry (for example, Hayes and Ford [1995]), which raises the question: what would a better replacement be? In this article, we argue that standardized tests are an effective and practical assessment of many aspects of machine intelligence, and should be part of any comprehensive measure of AI progress. While a crisp definition of machine intelligence remains elusive, we can enumerate some general properties we might expect of an intelligent machine. The list is potentially long (for example, Legg and Hutter [2007]), but should at least include the ability to (1) answer a wide variety of questions, (2) answer complex questions, (3) demonstrate commonsense and world knowledge, and (4) acquire new knowledge scalably. In addition, a suitable test should be clearly measurable, graduated (have a variety of levels of difficulty), not gameable, ambitious but realistic, and motivating. There are many other requirements we might add (for example, capabilities in robotics, vision, dialog), and thus any comprehensive measure of AI is likely to require a battery of different tests. However, standardized tests meet a surprising number of requirements, including the four listed, and thus should be a key component of a future battery of tests. As we will show, the tests require answering a wide variety of questions, including those requiring commonsense and world knowledge. In addition, they meet all the practical requirements, a huge advantage for any component of a future test of AI. Articles
Characterization of near-road pollutant gradients using path-integrated optical remote sensing.

Understanding motor vehicle emissions, near-roadway pollutant dispersion, and their potential impact to near-roadway populations is an area of growing environmental interest. As part of ongoing U.S. Environmental Protection Agency research in this area, a field study was conducted near Interstate 440 (I-440) in Raleigh, NC, in July and August of 2006. This paper presents a subset of measurements from the study focusing on nitric oxide (NO) concentrations near the roadway. Measurements of NO in this study were facilitated by the use of a novel path-integrated optical remote sensing technique called deep ultraviolet differential optical absorption spectroscopy (DUV-DOAS). This paper reviews the development and application of this measurement system. Time-resolved near-road NO concentrations are analyzed in conjunction with wind and traffic data to provide a picture of emissions and near-road dispersion for the study. Results show peak NO concentrations in the 150 ppb range during weekday morning rush hours with winds from the road accompanied by significantly lower afternoon and weekend concentrations. Traffic volume and wind direction are shown to be primary determinants of NO concentrations with turbulent diffusion and meandering accounting for significant near-road concentrations in off-wind conditions. The enhanced source capture performance of the open-path configuration allowed for robust comparisons of measured concentrations with a composite variable of traffic intensity coupled with wind transport (R2 = 0.84) as well as investigations on the influence of wind direction on NO dilution near the roadway. The benefits of path-integrated measurements for assessing line source impacts and evaluating models is presented. The advantages of NO as a tracer compound, compared with nitrogen dioxide, for investigations of mobile source emissions and initial dispersion under crosswind conditions are also discussed.
The influence of reading speed and line length on the effectiveness of reading from screen

With such a large volume of material accessible from the World Wide Web, there is an urgent need to increase our knowledge of factors in#uencing reading from screen. We investigate the e!ects of two reading speeds (normal and fast) and di!erent line lengths on comprehension, reading rate and scrolling patterns. Scrolling patterns are de"ned as the way in which readers proceed through the text, pausing and scrolling. Comprehension and reading rate are also examined in relation to scrolling patterns to attempt to identify some characteristics of e!ective readers. We found a reduction in overall comprehension when reading fast, but the type of information recalled was not dependent on speed. A medium line length (55 characters per line) appears to support e!ective reading at normal and fast speeds. This produced the highest level of comprehension and was also read faster than short lines. Scrolling patterns associated with better comprehension (more time in pauses and more individual scrolling movements) contrast with scrolling patterns used by faster readers (less time in pauses between scrolling). Consequently, e!ective readers can only be de"ned in relation to the aims of the reading task, which may favour either speed or accuracy. ( 2001 Academic Press