LLukas22/scidocs huggingface dataset:
Peroxidase activity, isoenzymes and histological localisation in sapwood and heartwood of Scots pine (Pinus sylvestris L.)

Peroxidase activity and isoenzymes of fresh wood samples of the third shoot of 12-year old trees and from the sapwood, transition zone and heartwood of c. 60-year old stems of Scots pine (Pinus sylvestris L.) were investigated. Wood samples were ground at −30°C, extracted, and the extracts concentrated c. 20-fold for peroxidase activity assays (guaiacol method) and for IEF-PAGE. At least 11 major isoenzymes could be found in the gels. Even the heartwood contained some peroxidase isoenzymes. Isoenzyme patterns of the juvenile wood did not change with the season. However, juvenile wood showed the highest peroxidase activity at the end of the growing season. Peroxidase activity decreased from the outer sapwood towards the heartwood. Thin sections of different wood zones stained for peroxidase revealed activity in ray parenchyma and resin canal epithelial cells. Intensive staining was localised in the bordered pits of vertical and ray tracheids, and in the end walls of ray parenchyma cells.
Differential neural circuitry and self-interest in real vs
hypothetical moral decisions

Classic social psychology studies demonstrate that people can behave in ways that contradict their intentions--especially within the moral domain. We measured brain activity while subjects decided between financial self-benefit (earning money) and preventing physical harm (applying an electric shock) to a confederate under both real and hypothetical conditions. We found a shared neural network associated with empathic concern for both types of decisions. However, hypothetical and real moral decisions also recruited distinct neural circuitry: hypothetical moral decisions mapped closely onto the imagination network, while real moral decisions elicited activity in the bilateral amygdala and anterior cingulate--areas essential for social and affective processes. Moreover, during real moral decision-making, distinct regions of the prefrontal cortex (PFC) determined whether subjects make selfish or pro-social moral choices. Together, these results reveal not only differential neural mechanisms for real and hypothetical moral decisions but also that the nature of real moral decisions can be predicted by dissociable networks within the PFC.
Evaluation of Electronic Cigarette Use (Vaping) Topography and Estimation of Liquid Consumption: Implications for Research Protocol Standards Definition and for Public Health Authorities’ Regulation

BACKGROUND
Although millions of people are using electronic cigarettes (ECs) and research on this topic has intensified in recent years, the pattern of EC use has not been systematically studied. Additionally, no comparative measure of exposure and nicotine delivery between EC and tobacco cigarette or nicotine replacement therapy (NRTs) has been established. This is important, especially in the context of the proposal for a new Tobacco Product Directive issued by the European Commission.


METHODS
A second generation EC device, consisting of a higher capacity battery and tank atomiser design compared to smaller cigarette-like batteries and cartomizers, and a 9 mg/mL nicotine-concentration liquid were used in this study. Eighty subjects were recruited; 45 experienced EC users and 35 smokers. EC users were video-recorded when using the device (ECIG group), while smokers were recorded when smoking (SM-S group) and when using the EC (SM-E group) in a randomized cross-over design. Puff, inhalation and exhalation duration were measured. Additionally, the amount of EC liquid consumed by experienced EC users was measured at 5 min (similar to the time needed to smoke one tobacco cigarette) and at 20 min (similar to the time needed for a nicotine inhaler to deliver 4 mg nicotine).


RESULTS
Puff duration was significantly higher in ECIG (4.2 ± 0.7 s) compared to SM-S (2.1 ± 0.4 s) and SM-E (2.3 ± 0.5 s), while inhalation time was lower (1.3 ± 0.4, 2.1 ± 0.4 and 2.1 ± 0.4 respectively). No difference was observed in exhalation duration. EC users took 13 puffs and consumed 62 ± 16 mg liquid in 5 min; they took 43 puffs and consumed 219 ± 56 mg liquid in 20 min. Nicotine delivery was estimated at 0.46 ± 0.12 mg after 5 min and 1.63 ± 0.41 mg after 20 min of use. Therefore, 20.8 mg/mL and 23.8 mg/mL nicotine-containing liquids would deliver 1 mg of nicotine in 5 min and 4 mg nicotine in 20 min, respectively. Since the ISO method significantly underestimates nicotine delivery by tobacco cigarettes, it seems that liquids with even higher than 24 mg/mL nicotine concentration would be comparable to one tobacco cigarette.


CONCLUSIONS
EC use topography is significantly different compared to smoking. Four-second puffs with 20-30 s interpuff interval should be used when assessing EC effects in laboratory experiments, provided that the equipment used does not get overheated. Based on the characteristics of the device used in this study, a 20 mg/mL nicotine concentration liquid would be needed in order to deliver nicotine at amounts similar to the maximum allowable content of one tobacco cigarette (as measured by the ISO 3308 method). The results of this study do not support the statement of the European Commission Tobacco Product Directive that liquids with nicotine concentration of 4 mg/mL are comparable to NRTs in the amount of nicotine delivered to the user.
Speaking Difficulties Encountered by Young EFL Learners

Speaking is the active use of language to express meaning, andfor young learners, the spoken language is the medium through which a new language is encountered, understood, practiced, and learnt. Rather than oral skills being simply one aspect of learning language, the spoken form in the young learner’s classroom acts as the prime source of language learning. However,speaking problems can be major challenges to effective foreign language learning and communication. English as foreign language (EFL) learners, no matter how much they know about the English language, still face many speaking difficulties.Many studies have indicated that oral language development has largely been neglected in the classroom, and most of the time, oral language in the classroom is used more by teachers than by students. However, oral language, even as used by the teacher, hardly ever functions as a means for students to gain knowledge and explore ideas. To develop the knowledge to deal with oral communication problems in an EFL context, researchers first need to know the real nature of those problems and the circumstances in which ‘problems’ are constructed.
Hilbertian Repulsive Effect and Dark Energy

A repulsive gravitational effect of general relativity (without cosmological term), which was pointed out by Hilbert many years ago, could play a decisive role in the explanation of the observational data concerning the accelerated expansion of the universe.
Using Machine Learning Algorithms for Breast Cancer Risk Prediction and Diagnosis

Breast cancer represents one of the diseases that make a high number of deaths every year. It is the most common type of all cancers and the main cause of women’s deaths worldwide. Classification and data mining methods are an effective way to classify data. Especially in medical field, where those methods are widely used in diagnosis and analysis to make decisions. In this paper, a performance comparison between different machine learning algorithms: Support Vector Machine (SVM), Decision Tree (C4.5), Naive Bayes (NB) and k Nearest Neighbors (k-NN) on the Wisconsin Breast Cancer (original) datasets is conducted. The main objective is to assess the correctness in classifying data with respect to efficiency and effectiveness of each algorithm in terms of accuracy, precision, sensitivity and specificity. Experimental results show that SVM gives the highest accuracy (97.13%) with lowest error rate. All experiments are executed within a simulation environment and conducted in WEKA data mining tool. © 2016 The Authors. Published by Elsevier B.V. Peer-review under responsibility of the Conference Program Chairs.
Wearable Activity Tracking in Car Manufacturing

A context-aware wearable computing system could support a production or maintenance worker by recognizing the worker's actions and delivering just-in-time information about activities to be performed.
Burnout among U.S. medical students, residents, and early career physicians relative to the general U.S. population.

PURPOSE
To compare the prevalence of burnout and other forms of distress across career stages and the experiences of trainees and early career (EC) physicians versus those of similarly aged college graduates pursuing other careers.


METHOD
In 2011 and 2012, the authors conducted a national survey of medical students, residents/fellows, and EC physicians (≤ 5 years in practice) and of a probability-based sample of the general U.S. population. All surveys assessed burnout, symptoms of depression and suicidal ideation, quality of life, and fatigue.


RESULTS
Response rates were 35.2% (4,402/12,500) for medical students, 22.5% (1,701/7,560) for residents/fellows, and 26.7% (7,288/27,276) for EC physicians. In multivariate models that controlled for relationship status, sex, age, and career stage, being a resident/fellow was associated with increased odds of burnout and being a medical student with increased odds of depressive symptoms, whereas EC physicians had the lowest odds of high fatigue. Compared with the population control samples, medical students, residents/fellows, and EC physicians were more likely to be burned out (all P < .0001). Medical students and residents/fellows were more likely to exhibit symptoms of depression than the population control samples (both P < .0001) but not more likely to have experienced recent suicidal ideation.


CONCLUSIONS
Training appears to be the peak time for distress among physicians, but differences in the prevalence of burnout, depressive symptoms, and recent suicidal ideation are relatively small. At each stage, burnout is more prevalent among physicians than among their peers in the U.S. population.
Development and validation of the stroke action test.

BACKGROUND AND PURPOSE
Accurately assessing the public's readiness to respond to stroke is important. Most published measures are based on recall or recognition of stroke symptoms, or knowledge of the best action for stroke when the diagnosis is provided. The purpose of this study was to develop and evaluate a new written instrument whose items require the respondent to associate individual symptoms with the most appropriate action.


METHODS
The Stroke Action Test (STAT) contains 21 items that name or describe stroke symptoms from all 5 groups of warning signs and 7 items that are nonstroke symptoms. For each item, the respondent selects 1 of 4 options: call 911, call doctor, wait 1 hour, or wait 1 day. The instrument validation sample included 249 subjects from community-based organizations. Score reliability and validity were analyzed using multiple data and information sources.


RESULTS
The mean overall STAT score (all 28 items) for the lay people was 36.8%. On average, they chose call 911 for 34.1% of the stroke symptoms. They chose call doctor for 39.4% of the stroke symptoms, wait 1 hour for 20.1%, and wait 1 day for 6.0%. Score reliability is good (alpha=0.83). Evidence confirming score validity is presented based on analysis of item content and response patterns, and examination of the relationships between test scores and key variables related to stroke knowledge.


CONCLUSIONS
STAT directly assesses a critical aspect of practical stroke knowledge that has been largely overlooked and provides scores with good reliability and validity.
Portable video supercomputing

As inexpensive imaging chips and wireless telecommunications are incorporated into an increasing array, of portable products, the need for high efficiency, high throughput embedded processing will become an important challenge in computer architecture. Videocentric applications, such wireless videoconferencing, real-time video enhancement and analysis, and new, immersive modes of distance education, will exceed the computational capabilities of current microprocessor and digital signal processor (DSP) architectures. A new class of embedded computers, portable video supercomputers, will combine supercomputer performance with the energy efficiency required for deployment in portable systems. We examine one candidate portable video supercomputer, a low memory, monolithically integrated SIMD architecture (SIMPil) that exploits the substantial data parallelism that exists in a suite of implemented video processing applications. The processing element microarchitecture is optimized using a novel technique that combines application simulation and technology modeling to provide a desired combination of performance, area, and energy consumption. Analysis results show that, for MPEG encoding, a SIMPil array implemented in 100 nm CMOS provides 100x greater performance and 10x higher energy efficiency than today's DSPs implemented 150 nm CMOS. This is accomplished using execution parallelism and a carefully selected processing element design. This research demonstrates that appropriately designed SIMD arrays, implemented monolithically in today's technology, can provide high performance and high efficiency for embedded video processing.
DASAR EPISTEMOLOGI ILMU KOGNITIF DALAMTINJAUAN PEMIKIRAN TIGA DUNIA KARL RAIMUNDPOPPER

The title of this tesis is "The Epistemology Background Of Cognitive
Science In Perspective Of Karl Raimund Popper's Three World". The thought of
Three World is the one of the most important work from Karl R. Popper, because
The Three World is ontological, and also epistemological basis of Karl R Popper's
philosophy. This Karl R. Popper's Three World thought, then will be use for
looking the basic epistemology in cognitive science. The aims of this research is
to: (1) describe the definition and the main problems of cognitive science, (2) find
epistemology background in cognitive science.
This research is a library researched using several methods, i.e:
Interpretation - to understand the contents of data which been found in Karl R.
Popper's Three World
A 2.02–5.16 fJ/Conversion Step 10 Bit Hybrid Coarse-Fine SAR ADC With Time-Domain Quantizer in 90 nm CMOS

This paper presents an ultra-low-voltage and power-efficient 10 bit hybrid successive approximation register (SAR) analog-to-digital converter (ADC). For reducing the digital-to-analog converter (DAC) capacitance and comparator requirement, we propose a hybrid architecture comprising a coarse 7 bit SAR ADC and fine 3.5 bit time-to-digital converter (TDC). The Vcm-based switching method is adopted for coarse conversion to reduce DAC power and maintain common mode. The residual voltage after coarse conversion is converted to time domain, and the fine TDC detects the least three bits with 0.5 bit redundancy by using a Vernier delay structure. Offset calibration and delay time locking are implemented to guarantee the ADC performance under process variation. The test chip, fabricated in 90 nm CMOS technology, occupied a core area of 0.04 mm2. With a 0.4 V supply and a Nyquist rate input, the prototype consumed 200 nW at 250 kS/s and achieved an ENOB of 8.63 bits and a SFDR of 78.5 dB. The operation frequency was scalable from 250 kS/s to 4 MS/s. The converter had a power supply range of 0.4-0.7 V, and the figure of merit (FoM) were 2.02-5.16 fJ/conversion step.
Switching from zidovudine/lamivudine to tenofovir/emtricitabine improves fat distribution as measured by fat mass ratio.

OBJECTIVES
Fat mass ratio (FMR) has been suggested as an objective indicator of abnormal body fat distribution in HIV infection. Although it could provide more comprehensive information on body fat changes than limb fat mass, FMR has scarcely been used in clinical trials examining body fat distribution in HIV-infected patients.


METHODS
A subanalysis of a controlled, randomized clinical trial in virologically suppressed HIV-1-infected men switching from zidovudine (ZDV)/lamivudine (3TC) to emtricitabine (FTC)/tenofovir (TDF) versus continuing on ZDV/3TC was carried out. FMR was assessed by dual X-ray absorptiometry (DEXA) for a period of 72 weeks. Lipoatrophy was defined as FMR ≥ 1.5. Multivariate linear regression models for the change in FMR from baseline were fitted.


RESULTS
Sixty-five men were randomized and treated (28 in the FTC/TDF arm and 37 in the ZDV/3TC arm), and 57 completed the study (25 and 32 in each arm, respectively). In the FTC/TDF arm, adjusted mean FMR decreased by 0.52 at week 72 (P = 0.014), and in the ZDV/3TC arm it increased by 0.13 (P = 0.491; P between arms = 0.023). Among subjects with lipoatrophy (baseline FMR ≥ 1.5), adjusted FMR decreased by 0.76 (P = 0.003) in the FTC/TDF arm and increased by 0.21 (P = 0.411; P between arms = 0.009) in the ZDV/3TC arm. Baseline FMR and treatment group were significant predictors (P < 0.05) of post-baseline changes in FMR.


CONCLUSIONS
Switching from ZDV/3TC to FTC/TDF led to an improvement in FMR, compared with progressive worsening of FMR in subjects receiving ZDV/3TC, showing that fat mass not only increased but was also distributed in a healthier way after the switch.
Impact of coronary chronic total occlusions on long-term mortality in patients undergoing coronary artery bypass grafting.

OBJECTIVES
The presence of a coronary chronic total occlusion (CTO) is a common consideration in favour of surgical revascularization. However, studies have shown that not all patients undergoing coronary artery bypass grafting (CABG) have a bypass graft placed on the CTO vessel. The aim of this study was to determine the prevalence of CTO among patients referred for CABG and the significance of incomplete CTO revascularization in these patients.


METHODS
The study included 405 consecutive patients undergoing CABG during a 2-year period. Clinical, echocardiographic and angiographic data were collected. Determination of whether or not a CTO was bypassed was made by correlating data from the surgical reports and preprocedural angiograms. The primary end point of this study was 5-year all-cause mortality.


RESULTS
Two hundred and twenty-one CTOs were found in 174 patients: 132 patients (76) had 1 CTO; 37 (21) had 2 CTOs and 5 (3) had 3 CTOs. Of the 221 CTOs, 191 (86%) were bypassed. All left anterior descending (LAD) CTOs were grafted; however, 12 of left circumflex and 22% of right coronary artery CTOs did not receive bypass grafts. Incomplete CTO revascularization was associated with older age, more comorbidities, including stroke, renal impairment and lower ejection fraction. However, incomplete CTO revascularization was not associated with increased 5-year mortality.


CONCLUSIONS
Coronary CTOs are a common finding in patients referred for bypass surgery. The presence of a CTO is not independently associated with an adverse long-term outcome. While most CTOs are successfully bypassed, failure to revascularize a non-LAD CTO is not associated with adverse long-term outcome.
Prediction of pneumonia 30-day readmissions: a single-center attempt to increase model performance.

BACKGROUND
Existing models developed to predict 30 days readmissions for pneumonia lack discriminative ability. We attempted to increase model performance with the addition of variables found to be of benefit in other studies.


METHODS
From 133,368 admissions to a tertiary-care hospital from January 2009 to March 2012, the study cohort consisted of 956 index admissions for pneumonia, using the Centers for Medicare and Medicaid Services definition. We collected variables previously reported to be associated with 30-day all-cause readmission, including vital signs, comorbidities, laboratory values, demographics, socioeconomic indicators, and indicators of hospital utilization. Separate logistic regression models were developed to identify the predictors of all-cause hospital readmission 30 days after discharge from the index pneumonia admission for pneumonia-related readmissions, and for pneumonia-unrelated readmissions.


RESULTS
Of the 965 index admissions for pneumonia, 148 (15.5%) subjects were readmitted within 30 days. The variables in the multivariate-model that were significantly associated with 30-day all-cause readmission were male sex (odds ratio 1.59, 95% CI 1.03-2.45), 3 or more previous admissions (odds ratio 1.84, 95% CI 1.22-2.78), chronic lung disease (odds ratio 1.63, 95% CI 1.07-2.48), cancer (odds ratio 2.18, 95% CI 1.24-3.84), median income < $43,000 (odds ratio 1.82, 95% CI 1.18-2.81), history of anxiety or depression (odds ratio 1.62, 95% CI 1.04-2.52), and hematocrit < 30% (odds ratio 1.86, 95% CI 1.07-3.22). The model performance, as measured by the C statistic, was 0.71 (0.66-0.75), with minimal optimism according to bootstrap re-sampling (optimism corrected C statistic 0.67).


CONCLUSIONS
The addition of socioeconomic status and healthcare utilization variables significantly improved model performance, compared to the model using only the Centers for Medicare and Medicaid Services variables.
Incidence of congenital rubella syndrome at a hospital serving a predominantly Hispanic population, El Paso, Texas.

OBJECTIVE
The current epidemiology of rubella reveals an increase in the number of cases among adult Hispanics and an increase in the number of congenital rubella syndrome (CRS) cases among infants of Hispanic mothers. Recent rubella outbreaks have occurred primarily among adult Hispanics, many of whom are foreign-born natives of countries where rubella vaccination is not routine or has only recently been implemented. The objective of this study was to estimate the incidence of CRS in a hospital serving a predominantly Hispanic population.


METHODS
Hospital charts of infants <1 year old discharged between January 1, 1994 and December 31, 1996 with International Classification of Diseases, Ninth Revision (ICD-9) discharge codes consistent with CRS were reviewed; we looked for cataracts, deafness, congenital heart defects, dermal erythropoiesis, microcephaly, meningoencephalitis, and other defects associated with CRS. We abstracted data on maternal and infant ethnicity, maternal age, gestational age, infants' birth weight, infants' clinical characteristics, and laboratory evaluation. Cases were categorized according to the Council of State and Territorial Epidemiologists' case classification for CRS.


RESULTS
Of the 182 infants with 1 or more ICD-9 codes consistent with CRS, 6 (3.3%) met either the confirmed or probable case definition for CRS. Two infants met the definition for confirmed CRS. Although laboratory tests for rubella immunoglobulin M antibodies were positive for both of these infants, only 1 of the cases had been reported to the state health department. Four other infants had clinical presentations that met the definition for a probable case. One of these had been tested for rubella immunoglobulin M antibodies, and the test was negative. The other 3 had not been tested. The rate of infants meeting the definition of confirmed and probable CRS was 3.1 per 10 000 hospital births. All confirmed and probable cases were among infants born to Hispanic mothers. Maternal country of origin was Mexico for the 2 confirmed cases and 1 of the probable cases, and unknown for the remaining 3 probable cases.


CONCLUSION
The rate of confirmed and probable CRS among infants in this predominantly Hispanic population is higher than the reported rate in the United States in the vaccine era, which has been reported to range from approximately 0.01-0.08 per 10 000 live births. These findings indicate a need for heightened awareness of CRS among physicians who serve populations at risk for rubella. Physicians should report all confirmed and probable CRS cases to the state health department. The lack of appropriate laboratory testing in 3 infants with probable CRS indicates that physicians should consider a diagnosis of CRS in infants with some signs consistent with CRS, particularly in areas serving high numbers of individuals at risk for rubella.