LLukas22/scidocs huggingface dataset:
Reduced lung-cancer mortality with low-dose computed tomographic screening.

BACKGROUND
The aggressive and heterogeneous nature of lung cancer has thwarted efforts to reduce mortality from this cancer through the use of screening. The advent of low-dose helical computed tomography (CT) altered the landscape of lung-cancer screening, with studies indicating that low-dose CT detects many tumors at early stages. The National Lung Screening Trial (NLST) was conducted to determine whether screening with low-dose CT could reduce mortality from lung cancer.


METHODS
From August 2002 through April 2004, we enrolled 53,454 persons at high risk for lung cancer at 33 U.S. medical centers. Participants were randomly assigned to undergo three annual screenings with either low-dose CT (26,722 participants) or single-view posteroanterior chest radiography (26,732). Data were collected on cases of lung cancer and deaths from lung cancer that occurred through December 31, 2009.


RESULTS
The rate of adherence to screening was more than 90%. The rate of positive screening tests was 24.2% with low-dose CT and 6.9% with radiography over all three rounds. A total of 96.4% of the positive screening results in the low-dose CT group and 94.5% in the radiography group were false positive results. The incidence of lung cancer was 645 cases per 100,000 person-years (1060 cancers) in the low-dose CT group, as compared with 572 cases per 100,000 person-years (941 cancers) in the radiography group (rate ratio, 1.13; 95% confidence interval [CI], 1.03 to 1.23). There were 247 deaths from lung cancer per 100,000 person-years in the low-dose CT group and 309 deaths per 100,000 person-years in the radiography group, representing a relative reduction in mortality from lung cancer with low-dose CT screening of 20.0% (95% CI, 6.8 to 26.7; P=0.004). The rate of death from any cause was reduced in the low-dose CT group, as compared with the radiography group, by 6.7% (95% CI, 1.2 to 13.6; P=0.02).


CONCLUSIONS
Screening with the use of low-dose CT reduces mortality from lung cancer. (Funded by the National Cancer Institute; National Lung Screening Trial ClinicalTrials.gov number, NCT00047385.).
Automotive Mechatronic Systems : A Curriculum Outline

Abstract In this paper, a review of mechatronics is presented with emphasis on the desired qualities of university graduates as viewed by industry. A detailed description of a sequence of two new courses on automotive mechatronic systems and a specialized laboratory are discussed. The new coursework has been added to the curriculum towards the degree of systems engineer at Oakland University and will be first offered in Fall '97. The development of the courses and the laboratory has been supported by Ford Motor Company.
Stock Market Prediction based on Time Series Data and Market Sentiment

In this project, we would like to create a system that predicts stock market movements on a given day, based on time series data and market sentiment analysis. We will use Twitter data on that day to predict the market sentiment and S&P 500 values to perform analysis on historical data.
Canine intraspinal meningiomas: imaging features, histopathologic classification, and long-term outcome in 34 dogs.

BACKGROUND
Meningioma is the most common primary intraspinal nervous system tumor in dogs. Clinical findings, clinicopathologic data, and treatment of these tumors have been reported sporadically, but little information is available regarding cerebrospinal fluid (CSF) analysis, histologic tumor grade, or efficacy of radiation therapy as an adjunct to cytoreductive surgery.


ANIMALS
Dogs with histologically confirmed intraspinal meningiomas (n = 34).


METHODS
A retrospective study of dogs with intraspinal meningiomas between 1984 and 2006 was carried out. Signalment, historical information, physical examination, clinicopathologic data, radiation therapy protocols, surgery reports, and all available images were reviewed. All tumors were histologically classified and graded as defined by the international World Health Organization classification scheme for central nervous system tumors.


RESULTS
Intraspinal mengiomas in dogs are most common in the cervical spinal cord but can be found throughout the neuraxis. Location is correlated with histologic grade, with grade I tumors more likely to be in the cervical region than grade II tumors. Myelography generally shows an intradural extramedullary compressive lesion. On magnetic resonance imaging, the masses are strongly and uniformly contrast enhancing and a dural tail often is present. CSF analysis usually shows increased protein concentration with mild to moderate mixed pleocytosis. Surgical resection is an effective means of improving neurologic status, and adjunctive radiation therapy may lead to an improved outcome.


CONCLUSIONS AND CLINICAL IMPORTANCE
Biopsy is necessary for definitive diagnosis, but imaging and CSF analysis can suggest a diagnosis of meningioma. Treatment of meningiomas with surgery and radiation therapy can result in a fair to excellent prognosis.
A Survey of Insider Attack Detection Research

This paper surveys proposed solutions for the problem of insider attack detection appearing in the computer security research literature. We distinguish between masqueraders and traitors as two distinct cases of insider attack. After describing the challenges of this problem and highlighting current approaches and techniques pursued by the research community for insider attack detection, we suggest directions for future research.
Hospital purchasing alliances: utilization, services, and performance.

BACKGROUND
Hospital purchasing alliances are voluntary consortia of hospitals that aggregate their contractual purchases of supplies from manufacturers. Purchasing groups thus represent pooling alliances rather than trading alliances (e.g., joint ventures). Pooling alliances have been discussed in the health care management literature for years but have never received much empirical investigation. They represent a potentially important source of economies of scale for hospitals.


PURPOSES
This study represents the first national survey of hospital purchasing alliances. The survey analyzes alliance utilization, services, and performance from the perspective of the hospital executive in charge of materials management. This study extends research on pooling alliances, develops national benchmark statistics, and answers important issues raised recently about pooling alliances.


METHODOLOGY/APPROACH
The investigators surveyed hospital members in the seven largest purchasing alliances (that account for 93% of all hospital purchases) and individual members of the Association of Healthcare Resource & Materials Management. The concatenated database yielded an approximate population of all hospital materials managers numbering 5,014.


FINDINGS
Hospital purchasing group alliances succeed in reducing health care costs by lowering product prices, particularly for commodity and pharmaceutical items. Alliances also reduce transaction costs through commonly negotiated contracts and increase hospital revenues via rebates and dividends. Thus, alliances may achieve purchasing economies of scale. Hospitals report additional value as evidenced by their long tenure and the large share of purchases routed through the alliances. Alliances appear to be less successful, however, in providing other services of importance and value to hospitals and in mediating the purchase of expensive physician preference items. There is little evidence that alliances exclude new innovative firms from the marketplace or restrict hospital access to desired products.


PRACTICE IMPLICATIONS
Pooling alliances appear successful in purchasing commodity and pharmaceutical products. Pooling alliances face the same issues as trading alliances in their efforts to work with physicians and the supply items they prefer.
A review of the human–horse relationship

Despite a long history of human-horse relationship, horse-related incidents and accidents do occur amongst professional and non professional “horse persons”. Recent studies show that their occurrence depend more on the frequency and amount of interactions with horses than on the level of competency, suggesting a strong need for specific research and training of humans working with horses. In the present study, we review the current scientific knowledge on human-horse relationships. We distinguish here short occasional interactions with familiar or unfamiliar horses (e.g. veterinary inspection) and long term bonds (e.g. horseowner). It appears clearly that research is needed in order to assess how to better approach the horse (position, posture, gaze...), what type of approaches and timing may help develop a positive bond, what influence human management and care has on the relationship, and how this can be adapted to have a positive influence on the relationship. On the other hand, adequate knowledge is readily available that may improve the present situation rapidly. Developing awareness and attention to behavioural cues given by horses would certainly help decreasing accidents among professionals when interacting. Another whole line is how to try and improve the development and maintenance of a really positive relationship. Studies show that deficits in the management conditions (housing, food, social context, training) may lead to relational problems. Different methods have been used in order to assess and improve the human-horse relation, especially in the young age. They reveal that the time and type of contact all play a role, while recent studies suggest that the use of conspecific social models might be a great help. We argue that an important theoretical framework could be Hinde (1979)’s definition of a relationship as an emerging bond from a series of interactions: partners have expectations on the next interaction on the basis of the previous ones. Understanding that a relationship is built up on the basis of a succession of interactions is an important step as it suggests that attention is being paid to the “positive” or “negative” valence of each interaction as a step for the next one. A better knowledge of learning rules is certainly necessary in this context not only to train the horse but also to counterbalance the unavoidable negative inputs that exist in routine procedures and reduce their impact on the relationship.
Quantifying the relative contributions of riparian and hillslope zones to catchment runoff: SMALL CATCHMENT RUNOFF SOURCES

[1] The spatial and temporal sources of headwater catchment runoff are poorly understood. We quantified the contributions of hillslopes and riparian zones to streamflow for two storm events in a highly responsive, steep, wet watershed located on the west coast of the South Island of New Zealand. We examined the spatial and temporal components of catchment storm flow using a simple continuity-based approach. We tested this with independent isotopic/solute mass balance hydrograph separation techniques. We monitored catchment runoff, internal hydrological response, isotopic, and solute dynamics at a trenched hillslope, and at hillslope and riparian positions in a 2.6-ha catchment. The gauged hillslope was used to isolate and quantify (by difference) riparian and hillslope zone contributions to the 2.6-ha headwater catchment. Utilizing flow-based approaches and a tracer-based mass balance mixing model, we found that hillslope runoff comprised 2–16% of total catchment storm runoff during a small 27-mm event and 47–55% during a larger 70-mm event. However, less than 4% of the new water collected at the catchment outlet originated from the hillslopes during each event. We found that in the 27-mm rain event, 84–97% of total storm runoff was generated in the riparian zone. In a larger 70-mm event, riparian water dominated total flow early in the event, although the hillslope became the main contributor once hillslope runoff was initiated. Despite the large amount of subsurface hillslope runoff in total storm runoff during the second larger event, riparian and channel zones accounted for 96% of the new water measured at the catchment outlet. Riparian water dominated between events, throughout small runoff events, and during early portions of large events. While this sequencing of catchment position contributions to flow has been conceptualized for some time, this is the first study to quantify this timing, constrained by hydrometric, isotopic, and solute approaches.
Modulation of human postprandial lipemia by changing ratios of polyunsaturated to saturated (P/S) fatty acid content of blended dietary fats: a cross-over design with repeated measures

BACKGROUND
Postprandial lipemia (PL) contributes to coronary artery disease. The fatty acid composition of dietary fats is potentially a modifiable factor in modulating PL response.


METHODS
This human postprandial study evaluated 3 edible fat blends with differing polyunsaturated to saturated fatty acids (P/S) ratios (POL = 0.27, AHA = 1.00, PCAN = 1.32). A cross-over design included mildly hypercholestrolemic subjects (9 men and 6 women) preconditioned on test diets fats at 31% energy for 7 days prior to the postprandial challenge on the 8th day with 50 g test fat. Plasma lipids and lipoproteins were monitored at 0, 1.5, 3.5, 5.5 and 7 hr.


RESULTS
Plasma triacylglycerol (TAG) concentrations in response to POL, AHA or PCAN meals were not significant for time x test meal interactions (P > 0.05) despite an observed trend (POL > AHA > PCAN). TAG area-under-the-curve (AUC) increased by 22.58% after POL and 7.63% after PCAN compared to AHA treatments (P > 0.05). Plasma total cholesterol (TC) response was not significant between meals (P > 0.05). Varying P/S ratios of test meals significantly altered prandial high density lipoprotein-cholesterol (HDL-C) concentrations (P < 0.001) which increased with decreasing P/S ratio (POL > AHA > PCAN). Paired comparisons was significant between POL vs PCAN (P = 0.009) but not with AHA or between AHA vs PCAN (P > 0.05). A significantly higher HDL-C AUC for POL vs AHA (P = 0.015) and PCAN (P = 0.001) was observed. HDL-C AUC increased for POL by 25.38% and 16.0% compared to PCAN and AHA respectively. Plasma low density lipoprotein-cholesterol (LDL-C) concentrations was significant (P = 0.005) between meals and significantly lowest after POL meal compared to PCAN (P = 0.004) and AHA (P > 0.05) but not between AHA vs PCAN (P > 0.05). AUC for LDL-C was not significant between diets (P > 0.05). Palmitic (C16:0), oleic (C18:1), linoleic (C18:2) and linolenic (C18:3) acids in TAGs and cholesteryl esters were significantly modulated by meal source (P < 0.05).


CONCLUSIONS
P/S ratio of dietary fats significantly affected prandial HDL-C levels without affecting lipemia.
The Impact Of Software-As-A-Service On Business Models Of Leading Software Vendors: Experiences From Three Exploratory Case Studies

The number of software vendors offering ‘Software-as-a-Service’ has been increasing in recent years. In the Software-as-a-Service model software is operated by the software vendor and delivered to the customer as a service. Existing business models and industry structures are challenged by the changes to the deployment and pricing model compared to traditional software. However, the full implications on the way companies create, deliver and capture value are not yet sufficiently analyzed. Current research is scattered on specific aspects, only a few studies provide a more holistic view of the impact from a business model perspective. For vendors it is, however, crucial to be aware of the potentially far reaching consequences of Software-as-a-Service. Therefore, a literature review and three exploratory case studies of leading software vendors are used to evaluate possible implications of Software-as-a-Service on business models. The results show an impact on all business model building blocks and highlight in particular the often less articulated impact on key activities, customer relationship and key partnerships for leading software vendors and show related challenges, for example, with regard to the integration of development and operations processes. The observed implications demonstrate the disruptive character of the concept and identify future research requirements.
Cost offset from a psychiatric consultation-liaison intervention with elderly hip fracture patients.

OBJECTIVE
The authors hypothesized that psychiatric liaison screening of elderly patients with hip fractures would shorten the average length of hospital stay and increase the proportion of patients who returned home after discharge.


METHOD
The study was performed at Mount Sinai Medical Center in New York and Northwestern Memorial Hospital in Chicago. The subjects were 452 patients 65 years or older who were consecutively admitted for surgical repair of fractured hips. During a baseline year the patients received traditional referral for psychiatric consultation. During the experimental year all the patients at Mount Sinai and the patients on one Northwestern Unit were screened for psychiatric consultation.


RESULTS
The patients who received psychiatric liaison screening had a higher consultation rate than those who received traditional consultation. The rates of DSM-III disorders in the experimental year were 56% at Mount Sinai and 60% at Northwestern. The mean length of stay was reduced from 20.7 to 18.5 days at Mount Sinai and from 15.5 to 13.8 days at Northwestern, resulting in reductions in hospital costs ($647/day) of $166,926 and $97,361, respectively. Fees generated from Medicare service delivery could have paid for the $20,000 psychiatric intervention cost at each site. There was no difference, however, between the two years in the discharge placement of patients.


CONCLUSIONS
Admission psychiatric liaison screening of elderly patients with hip fractures results in early detection of psychiatric morbidity, better psychiatric care, earlier discharge, and substantial cost savings to the hospital.
The invariants of the binary decimic

We consider the algebra of invariants of binary forms of degree 10 with complex coefficients, construct a system of parameters with degrees 2, 4, 6, 6, 8, 9, 10, 14 and find the 106 basic invariants.
Screening for Parkinson's disease with response time batteries: A pilot study

BACKGROUND
Although significant response time deficits (both reaction time and movement time) have been identified in numerous studies of patients with Parkinson's disease (PD), few attempts have been made to evaluate the use of these measures in screening for PD.


METHODS
Receiver operator characteristic curves were used to identify cutoff scores for a unit-weighted composite of two choice response tasks in a sample of 40 patients and 40 healthy participants. These scores were then cross-validated in an independent sample of 20 patients and 20 healthy participants.


RESULTS
The unit-weighted movement time composite demonstrated high sensitivity (90%) and specificity (90%) in the identification of PD. Movement time was also significantly correlated (r = 0.59, p < 0.025) with the motor score of the Unified Parkinson's Disease Rating Scale (UPDRS).


CONCLUSIONS
Measures of chronometric speed, assessed without the use of biomechanically complex movements, have a potential role in screening for PD. Furthermore, the significant correlation between movement time and UPDRS motor score suggests that movement time may be useful in the quantification of PD severity.
Managing medical and psychiatric comorbidity in individuals with major depressive disorder and bipolar disorder.

BACKGROUND
Most individuals with mood disorders experience psychiatric and/or medical comorbidity. Available treatment guidelines for major depressive disorder (MDD) and bipolar disorder (BD) have focused on treating mood disorders in the absence of comorbidity. Treating comorbid conditions in patients with mood disorders requires sufficient decision support to inform appropriate treatment.


METHODS
The Canadian Network for Mood and Anxiety Treatments (CANMAT) task force sought to prepare evidence- and consensus-based recommendations on treating comorbid conditions in patients with MDD and BD by conducting a systematic and qualitative review of extant data. The relative paucity of studies in this area often required a consensus-based approach to selecting and sequencing treatments.


RESULTS
Several principles emerge when managing comorbidity. They include, but are not limited to: establishing the diagnosis, risk assessment, establishing the appropriate setting for treatment, chronic disease management, concurrent or sequential treatment, and measurement-based care.


CONCLUSIONS
Efficacy, effectiveness, and comparative effectiveness research should emphasize treatment and management of conditions comorbid with mood disorders. Clinicians are encouraged to screen and systematically monitor for comorbid conditions in all individuals with mood disorders. The common comorbidity in mood disorders raises fundamental questions about overlapping and discrete pathoetiology.
Antimicrobial susceptibility patterns of Ureaplasma species and Mycoplasma hominis in pregnant women

BACKGROUND
Genital mycoplasmas colonise up to 80% of sexually mature women and may invade the amniotic cavity during pregnancy and cause complications. Tetracyclines and fluoroquinolones are contraindicated in pregnancy and erythromycin is often used to treat patients. However, increasing resistance to common antimicrobial agents is widely reported. The purpose of this study was to investigate antimicrobial susceptibility patterns of genital mycoplasmas in pregnant women.


METHODS
Self-collected vaginal swabs were obtained from 96 pregnant women attending an antenatal clinic in Gauteng, South Africa. Specimens were screened with the Mycofast Revolution assay for the presence of Ureaplasma species and Mycoplasma hominis. The antimicrobial susceptibility to levofloxacin, moxifloxacin, erythromycin, clindamycin and tetracycline were determined at various breakpoints. A multiplex polymerase chain reaction assay was used to speciate Ureaplasma positive specimens as either U. parvum or U. urealyticum.


RESULTS
Seventy-six percent (73/96) of specimens contained Ureaplasma spp., while 39.7% (29/73) of Ureaplasma positive specimens were also positive for M. hominis. Susceptibilities of Ureaplasma spp. to levofloxacin and moxifloxacin were 59% (26/44) and 98% (43/44) respectively. Mixed isolates (Ureaplasma species and M. hominis) were highly resistant to erythromycin and tetracycline (both 97% resistance). Resistance of Ureaplasma spp. to erythromycin was 80% (35/44) and tetracycline resistance was detected in 73% (32/44) of Ureaplasma spp. Speciation indicated that U. parvum was the predominant Ureaplasma spp. conferring antimicrobial resistance.


CONCLUSIONS
Treatment options for genital mycoplasma infections are becoming limited. More elaborative studies are needed to elucidate the diverse antimicrobial susceptibility patterns found in this study when compared to similar studies. To prevent complications in pregnant women, the foetus and the neonate, routine screening for the presence of genital mycoplasmas is recommended. In addition, it is recommended that antimicrobial susceptibility patterns are determined.