LLukas22/scidocs huggingface dataset:
Anther-mimicking floral guides exploit a conflict between innate preference and learning in bumblebees (Bombus terrestris)

Bee-pollinated plants are frequently dichogamous: e.g. each flower has a discernable male and female phase, with only the male phase offering a pollen reward. Pollen-collecting bees should therefore discriminate against female-phase flowers to maximise their rate of pollen harvest, but this behaviour would reduce plant fitness due to inferior pollination. Here, we test the hypothesis that flowers use pollen-mimicking floral guides to prevent flower-phase discrimination. Such floral guides resemble pollen in spectral reflection properties and are widespread among angiosperm flowers. In an array of artificial flowers, bumblebees learned less well to discriminate between flower variants simulating different flowering phases when both flower variants carried an additional pollen-yellow guide mark. This effect depended crucially on the pollen-yellow colour of the guide mark and on its spatial position within the artificial flower. We suggest that floral guides evolved to inhibit flower-phase learning in bees by exploiting the innate colour preferences of their pollinators.
Letermovir Prophylaxis for Cytomegalovirus in Hematopoietic-Cell Transplantation.

BACKGROUND
Cytomegalovirus (CMV) infection remains a common complication after allogeneic hematopoietic-cell transplantation. Letermovir is an antiviral drug that inhibits the CMV-terminase complex.


METHODS
In this phase 3, double-blind trial, we randomly assigned CMV-seropositive transplant recipients, 18 years of age or older, in a 2:1 ratio to receive letermovir or placebo, administered orally or intravenously, through week 14 after transplantation; randomization was stratified according to trial site and CMV disease risk. Letermovir was administered at a dose of 480 mg per day (or 240 mg per day in patients taking cyclosporine). Patients in whom clinically significant CMV infection (CMV disease or CMV viremia leading to preemptive treatment) developed discontinued the trial regimen and received anti-CMV treatment. The primary end point was the proportion of patients, among patients without detectable CMV DNA at randomization, who had clinically significant CMV infection through week 24 after transplantation. Patients who discontinued the trial or had missing end-point data at week 24 were imputed as having a primary end-point event. Patients were followed through week 48 after transplantation.


RESULTS
From June 2014 to March 2016, a total of 565 patients underwent randomization and received letermovir or placebo beginning a median of 9 days after transplantation. Among 495 patients with undetectable CMV DNA at randomization, fewer patients in the letermovir group than in the placebo group had clinically significant CMV infection or were imputed as having a primary end-point event by week 24 after transplantation (122 of 325 patients [37.5%] vs. 103 of 170 [60.6%], P<0.001). The frequency and severity of adverse events were similar in the two groups overall. Vomiting was reported in 18.5% of the patients who received letermovir and in 13.5% of those who received placebo; edema in 14.5% and 9.4%, respectively; and atrial fibrillation or flutter in 4.6% and 1.0%, respectively. The rates of myelotoxic and nephrotoxic events were similar in the letermovir group and the placebo group. All-cause mortality at week 48 after transplantation was 20.9% among letermovir recipients and 25.5% among placebo recipients.


CONCLUSIONS
Letermovir prophylaxis resulted in a significantly lower risk of clinically significant CMV infection than placebo. Adverse events with letermovir were mainly of low grade. (Funded by Merck; ClinicalTrials.gov number, NCT02137772 ; EudraCT number, 2013-003831-31 .).
Sources of Momentum Profits : Evidence on the Irrelevance of Characteristics ∗

Several recent studies document that sorting stocks first on certain stock-level characteristics and then on past returns results in elevated momentum profits. We show that such strategies enhance momentum profits simply by trading in stocks with more extreme past returns. Adjusted for this effect, elevated momentum profits resulting from characteristics (size, R2, turnover, age, analyst coverage, analyst forecast dispersion, market-to-book, price, illiquidity, credit rating) disappear almost entirely. Interaction patterns have been used to support behavioral and limits-to-arbitrage explanations of momentum; our findings imply that explanations of momentum should instead focus on the link between momentum profits and extreme past returns. JEL Classification: G11, G12, G14
Marine pharmacology in 2005-6: Marine compounds with anthelmintic, antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems, and other miscellaneous mechanisms of act

BACKGROUND
The review presents the 2005-2006 peer-reviewed marine pharmacology literature, and follows a similar format to the authors' 1998-2004 reviews. The preclinical pharmacology of chemically characterized marine compounds isolated from marine animals, algae, fungi and bacteria is systematically presented.


RESULTS
Anthelmintic, antibacterial, anticoagulant, antifungal, antimalarial, antiprotozoal, antituberculosis and antiviral activities were reported for 78 marine chemicals. Additionally 47 marine compounds were reported to affect the cardiovascular, immune and nervous system as well as possess anti-inflammatory effects. Finally, 58 marine compounds were shown to bind to a variety of molecular targets, and thus could potentially contribute to several pharmacological classes.


CONCLUSIONS
Marine pharmacology research during 2005-2006 was truly global in nature, involving investigators from 32 countries, and the United States, and contributed 183 marine chemical leads to the research pipeline aimed at the discovery of novel therapeutic agents.


GENERAL SIGNIFICANCE
Continued preclinical and clinical research with marine natural products demonstrating a broad spectrum of pharmacological activity will probably result in novel therapeutic agents for the treatment of multiple disease categories.
Eight years of seasonal burning and herbicidal brush control influence sapling longleaf pine growth, understory vegetation, and the outcome of an ensuing wildfire

To study how fire or herbicide use influences longleaf pine (Pinus palustris Mill.) overstory and understory vegetation, five treatments were initiated in a 5–6-year-old longleaf pine stand: check, biennial arborescent plant control by directed herbicide application, and biennial burning in March, May, or July. The herbicide or prescribed fire treatments were applied in 1999, 2001, 2003, and 2005. All prescribed fires were intense and averaged 700 kJ/s/m of fire front across all 12 burns. Using pretreatment variables as covariates, longleaf pine survival and volume per hectare were significantly less on the three prescribed fire treatments than on checks. Least-square means in 2006 for survival were 70, 65, 64, 58, and 56% and volume per hectare was 129, 125, 65, 84, and 80 m/ha on the check, herbicide, March-, May-, and July-burn treatments, respectively. A wildfire in March 2007 disproportionately killed pine trees on the study plots. In October 2007, pine volume per hectare was 85, 111, 68, 98, and 93 m/ha and survival was 32, 41, 53, 57, and 55% on the check, herbicide, March-, May-, and July-burn treatments, respectively, after dropping trees that died through January 2009 from the database. Understory plant cover was also affected by treatment and the ensuing wildfire. In September 2006, herbaceous plant cover averaged 4% on the two unburned treatments and 42% on the three prescribed fire treatments. Seven months after the wildfire, herbaceous plant cover averaged 42% on the two previously unburned treatments and 50% on the three prescribed fire treatments. Before the wildfire, understory tree cover was significantly greater on checks (15%) than on the other four treatments (1.3%), but understory tree cover was similar across all five treatments 7 months after the wildfire averaging 1.1%. The greater apparent intensity of the wildfire on the previously unburned treatments most likely resulted from a greater accumulation of fuels on the check and herbicide plots that also collectively had a higher caloric content than fuels on the biennially prescribed burned plots. These results showed the destructive force of wildfire to overstory trees in unburned longleaf pine stands while also demonstrating the rejuvenating effects of wildfire within herbaceous plant communities. They caution for careful reintroduction of prescribed fire even if fire was excluded for less than a decade. Published by Elsevier B.V.
Enterprise interoperability with SOA: a survey of service composition approaches

Service-oriented architecture (SOA) claims to facilitate the construction of flexible and loosely coupled business applications, and therefore is seen as an enabling factor for enterprise interoperability. The concept of service, which is central to SOA, is very convenient to address the matching of needs and capabilities in enterprise collaborations. In order to satisfy more demanding needs or to rapidly adapt to changing needs it is possible to perform service composition in order to combine the capabilities provided through several available services. This paper presents a survey on recent approaches for service composition. To perform this study a conceptual framework for service composition is proposed. This framework allows studying how different approaches deal with the service composition life-cycle and provides basic guidelines for their analysis, evaluation and comparison. The proposed framework is used to analyse five representative service composition approaches.
Hepatoprotective and Antioxidant Activity of Dunaliella salina in Paracetamol-induced Acute Toxicity in Rats

Paracetamol has a reasonable safety profile when taken in therapeutic doses. However, it could induce hepatotoxicity and even more severe fatal acute hepatic damage when taken in an overdose. The green alga, Dunaliella salina was investigated for hepatoprotective and antioxidant activity against paracetamol-induced liver damage in rats. Male albino Wistar rats overdosed with paracetamol showed liver damage and oxidative stress as indicated by significantly (P<0.05) increased serum levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, total and direct bilirubin, malondialdehyde, cholesterol and nitric oxide. At the same time, there were decreased activities of serum superoxide dismutase and total antioxidant capacity compared with the control group. Treatment with D. salina methanol extract at doses of 500 and 1000 mg/kg body weight or silymarin could significantly (P<0.05) decrease the liver damage marker enzymes, total and direct bilirubin, malondialdehyde, cholesterol and nitric oxide levels and increase the activities of superoxide dismutase and total antioxidant capacity in serum when compared with paracetamol intoxicated group. Liver histopathology also showed that D. salina reduced the centrilobular necrosis, congestion and inflammatory cell infiltration evoked by paracetamol overdose. These results suggest that D. salina exhibits a potent hepatoprotective effect on paracetamol-induced liver damage in rats, which may be due to both the increase of antioxidant enzymes activity and inhibition of lipid peroxidation.
Alveolar Dead Space Fraction Discriminates Mortality in Pediatric Acute Respiratory Distress Syndrome.

OBJECTIVES
Physiologic dead space is associated with mortality in acute respiratory distress syndrome, but its measurement is cumbersome. Alveolar dead space fraction relies on the difference between arterial and end-tidal carbon dioxide (alveolar dead space fraction = (PaCO2 - PetCO2) / PaCO2). We aimed to assess the relationship between alveolar dead space fraction and mortality in a cohort of children meeting criteria for acute respiratory distress syndrome (both the Berlin 2012 and the American-European Consensus Conference 1994 acute lung injury) and pediatric acute respiratory distress syndrome (as defined by the Pediatric Acute Lung Injury Consensus Conference in 2015).


DESIGN
Secondary analysis of a prospective, observational cohort.


SETTING
Tertiary care, university affiliated PICU.


PATIENTS
Invasively ventilated children with pediatric acute respiratory distress syndrome.


INTERVENTIONS
None.


MEASUREMENTS AND MAIN RESULTS
Of the 283 children with pediatric acute respiratory distress syndrome, 266 had available PetCO2. Alveolar dead space fraction was lower in survivors (median 0.13; interquartile range, 0.06-0.23) than nonsurvivors (0.31; 0.19-0.42; p < 0.001) at pediatric acute respiratory distress syndrome onset, but not 24 hours after (survivors 0.12 [0.06-0.18], nonsurvivors 0.14 [0.06-0.25], p = 0.430). Alveolar dead space fraction at pediatric acute respiratory distress syndrome onset discriminated mortality with an area under receiver operating characteristic curve of 0.76 (95% CI, 0.66-0.85; p < 0.001), better than either initial oxygenation index or PaO2/FIO2. In multivariate analysis, alveolar dead space fraction at pediatric acute respiratory distress syndrome onset was independently associated with mortality, after adjustment for severity of illness, immunocompromised status, and organ failures.


CONCLUSIONS
Alveolar dead space fraction at pediatric acute respiratory distress syndrome onset discriminates mortality and is independently associated with nonsurvival. Alveolar dead space fraction represents a single, useful, readily obtained clinical biomarker reflective of pulmonary and nonpulmonary variables associated with mortality.
Социальная структура придворного общества в эпоху ранних Аббасидов

The article observes theory of N.Elias and analyzes the medieval Arab culture and court society of the early Abbasids. Based on fiction and memoirs of courtier the author comes to conclusion about similarities and differences of French and the early Abbasids’ court societies’ social structure.
Improving quality improvement using achievable benchmarks for physician feedback: a randomized controlled trial.

CONTEXT
Performance feedback and benchmarking, common tools for health care improvement, are rarely studied in randomized trials. Achievable Benchmarks of Care (ABCs) are standards of excellence attained by top performers in a peer group and are easily and reproducibly calculated from existing performance data.


OBJECTIVE
To evaluate the effectiveness of using achievable benchmarks to enhance typical physician performance feedback and improve care.


DESIGN
Group-randomized controlled trial conducted in December 1996, with follow-up through 1998.


SETTING AND PARTICIPANTS
Seventy community physicians and 2978 fee-for-service Medicare patients with diabetes mellitus who were part of the Ambulatory Care Quality Improvement Project in Alabama.


INTERVENTION
Physicians were randomly assigned to receive a multimodal improvement intervention, including chart review and physician-specific feedback (comparison group; n = 35) or an identical intervention plus achievable benchmark feedback (experimental group; n = 35).


MAIN OUTCOME MEASURE
Preintervention (1994-1995) to postintervention (1997-1998) changes in the proportion of patients receiving influenza vaccination; foot examination; and each of 3 blood tests measuring glucose control, cholesterol level, and triglyceride level, compared between the 2 groups.


RESULTS
The proportion of patients who received influenza vaccine improved from 40% to 58% in the experimental group (P<.001) vs from 40% to 46% in the comparison group (P =.02). Odds ratios (ORs) for patients of achievable benchmark physicians vs comparison physicians who received appropriate care after the intervention, adjusted for preintervention care and nesting of patients within physicians, were 1.57 (95% confidence interval [CI], 1.26-1.96) for influenza vaccination, 1.33 (95% CI, 1.05-1.69) for foot examination, and 1.33 (95% CI, 1.04-1.69) for long-term glucose control measurement. For serum cholesterol and triglycerides, the achievable benchmark effect was statistically significant only after additional adjustment for physician characteristics (OR, 1.40 [95% CI, 1.08-1.82] and OR, 1.40 [95% CI, 1.09-1.79], respectively).


CONCLUSION
Use of achievable benchmarks significantly enhances the effectiveness of physician performance feedback in the setting of a multimodal quality improvement intervention.
Mobile Cloud Computing Model and Big Data Analysis for Healthcare Applications

Mobile devices are increasingly becoming an indispensable part of people's daily life, facilitating to perform a variety of useful tasks. Mobile cloud computing integrates mobile and cloud computing to expand their capabilities and benefits and overcomes their limitations, such as limited memory, CPU power, and battery life. Big data analytics technologies enable extracting value from data having four Vs: volume, variety, velocity, and veracity. This paper discusses networked healthcare and the role of mobile cloud computing and big data analytics in its enablement. The motivation and development of networked healthcare applications and systems is presented along with the adoption of cloud computing in healthcare. A cloudlet-based mobile cloud-computing infrastructure to be used for healthcare big data applications is described. The techniques, tools, and applications of big data analytics are reviewed. Conclusions are drawn concerning the design of networked healthcare systems using big data and mobile cloud-computing technologies. An outlook on networked healthcare is given.
Generation and Modulation of a 94-GHz Signal Using Electrooptic Modulators

Wireless data transmission at 10.6 Gb/s on a 94-GHz carrier is achieved using photonic components operating at frequencies less than 18 GHz, including a laser diode, two lithium niobate modulators, and an arrayed waveguide grating. A uni- traveling-carrier photodiode is used to convert the doubly modulated optical signal to a modulated millimeter-wave (mmW) carrier. Two antennas are used to transmit and receive the data-encoded mmW signal. A Schottky-diode detector is used to detect the on-off keyed data on the mmW signal at power levels greater than -20 dBm. MMW wireless signals are measured out to a distance of 800 m.
Neural Cross-lingual Named Entity Recognition with Minimal Resources

For languages with no annotated resources, unsupervised transfer of natural language processing models such as named-entity recognition (NER) from resource-rich languages would be an appealing capability. However, differences in words and word order across languages make it a challenging problem. To improve mapping of lexical items across languages, we propose a method that finds translations based on bilingual word embeddings. To improve robustness to word order differences, we propose to use self-attention, which allows for a degree of flexibility with respect to word order. We demonstrate that these methods achieve state-of-the-art or competitive NER performance on commonly tested languages under a cross-lingual setting, with much lower resource requirements than past approaches. We also evaluate the challenges of applying these methods to Uyghur, a lowresource language.1
Security architecture for cloud networking

Cloud computing offers reduced capital expenditure, operational risks, complexity and maintenance, and increased scalability while providing services at different abstraction levels, namely Software-as-a-Service (SaaS), Platform-as-a-Service (PaaS), and Infrastructure-as-a-Service (IaaS). A new approach called cloud networking adds networking functionalities to cloud computing and enables dynamic and flexible placement of virtual resources crossing provider borders. This allows various kinds of optimization, e.g., reducing latency or network load. However, this approach introduces new security challenges. This paper presents a security architecture that enables a user of cloud networking to define security requirements and enforce them in the cloud networking infrastructure.
Longitudinal changes in awareness over 36 months in patients with mild Alzheimer's disease.

BACKGROUND
Longitudinal changes in awareness in dementia have been studied with short follow-up time and mostly in small patient groups (including patients with moderate dementia). We investigated awareness in patients with mild Alzheimer's disease (AD) over 36 months and studied if a decline in awareness was associated with decline in cognition and increase in neuropsychiatric symptoms.


METHODS
Awareness was measured on a categorical scale in 95 AD patients (age ≥50 years, Mini-Mental State Examination (MMSE) score ≥20). Awareness was rated at three time points (follow-up at 12 and 36 months) where MMSE, Neuropsychiatric Inventory (NPI-Q), and Cornell scale for Depression in Dementia also were applied.


RESULTS
At 12 months, 26% had lower awareness rating as compared to baseline and at 36 months lower awareness ratings were found in 39%. At both visits, 16% had higher awareness rating as compared to baseline. Patients with lower awareness at 36 months as compared to baseline had a more rapid increase in NPI-Q score (p = 0.002) over 36 months as compared to patients with stable or improved awareness over 36 months. A more rapid decline in MMSE score was observed for patients with lower awareness at 36 months (as compared to baseline) but only when compared to patients in whom awareness improved over time.


CONCLUSIONS
The results show essentially no clear relationship between cognitive decline over three years and awareness. In some cases, awareness remained stable or even improved despite significant cognitive decline. In the subgroup where awareness declined over time, overall ratings of neuropsychiatric symptoms declined more rapidly than in the remaining patients.