LLukas22/scidocs huggingface dataset:
The Effect of Proprioceptive Neuromuscular Facilitation Therapy on Pain and
Function

[Purpose] The present study examined the effects of treatment using PNF extension techniques on the pain, pressure pain, and neck and shoulder functions of the upper trapezius muscles of myofascial pain syndrome (MPS) patients. [Subjects] Thirty-two patients with MPS in the upper trapezius muscle were divided into two groups: a PNF group (n=16), and a control group (n=16) [Methods] The PNF group received upper trapezius muscle relaxation therapy and shoulder joint stabilizing exercises. Subjects in the control group received only the general physical therapies for the upper trapezius muscles. Subjects were measured for pain on a visual analog scale (VAS), pressure pain threshold (PPT), the neck disability index (NDI), and the Constant-Murley scale (CMS). [Results] None of the VAS, PPT, and NDI results showed significant differences between the groups, while performing postures, internal rotation, and external rotation among the CMS items showed significant differences between the groups. [Conclusion] Exercise programs that apply PNF techniques can be said to be effective at improving the function of MPS patients.
Behaviour of human osteoblastic cells cultured on plasma-sprayed titanium implants in the presence of nicotine.

OBJECTIVES
The aim of this work was to analyse the behaviour of human bone marrow osteoblastic cells cultured on the surface of routinely used plasma-sprayed titanium implants in the presence of plasmatic and salivary nicotine levels reported in smokers.


MATERIAL AND METHODS
Human bone marrow cells (first subculture) were seeded on titanium implants and cultured for 35 days in alpha-minimal essential medium supplemented with 10% foetal bovine serum, 50 microg/ml ascorbic acid, 10 mM beta-glycerophosphate and 10 nM dexamethasone. Seeded implants were exposed to nicotine, 10-1 mg/ml, from days 1 to 35, and characterized for cell morphology, viability/proliferation, alkaline phosphatase (ALP) activity and matrix mineralization.


RESULTS
Low levels of nicotine, 10 and 50 ng/ml, representative of the plasma concentrations reported in smokers, did not cause significant effects in the cell behaviour, although a small induction in cell growth and functional activity appeared to occur. Higher nicotine levels, 0.01-1 mg/ml, within those attained in saliva through tobacco use, caused evident dose-dependent effects in osteoblastic cell behaviour, i.e., a stimulatory effect in cell growth, ALP activity and matrix mineralization, at concentrations up to 0.2 mg/ml, and a deleterious effect at higher levels.


CONCLUSIONS
Considering the high tissue diffusion potential of nicotine, the results suggest the possibility of a direct modulation of the osteoblast activity as a contributing factor to the overall effect of nicotine in the bone microenvironment around dental implants.
Analysis and validation of proteomic data generated by tandem mass spectrometry

The analysis of the large amount of data generated in mass spectrometry–based proteomics experiments represents a significant challenge and is currently a bottleneck in many proteomics projects. In this review we discuss critical issues related to data processing and analysis in proteomics and describe available methods and tools. We place special emphasis on the elaboration of results that are supported by sound statistical arguments.
Looking at movies and cartoons: eye-tracking evidence from Williams syndrome and autism.

BACKGROUND
Autism and Williams syndrome (WS) are neuro-developmental disorders associated with distinct social phenotypes. While individuals with autism show a lack of interest in socially important cues, individuals with WS often show increased interest in socially relevant information.


METHODS
The current eye-tracking study explores how individuals with WS and autism preferentially attend to social scenes and movie extracts containing human actors and cartoon characters. The proportion of gaze time spent fixating on faces, bodies and the scene background was investigated.


RESULTS
While individuals with autism preferentially attended to characters' faces for less time than was typical, individuals with WS attended to the same regions for longer than typical. For individuals with autism atypical gaze behaviours extended across human actor and cartoon images or movies but for WS atypicalities were restricted to human actors.


CONCLUSIONS
The reported gaze behaviours provide experimental evidence of the divergent social interests associated with autism and WS.
Diagnostic signs of accommodative insufficiency.

PURPOSE
To determine which are the most sensitive tests, together with accommodative amplitude, to classify accommodative insufficiency (Al), we analyzed the relation between monocular estimated method (MEM) dynamic retinoscopy, monocular and binocular accommodative facility (MAF, BAF), and positive relative accommodation (PRA) with or without the presence of reduced amplitude of accommodation.


METHODS
We studied 328 symptomatic patients who presented consecutively to an optometric clinic. From this sample, we selected the 41 patients who presented amplitude of accommodation at least 2 D below the minimum age-appropriate amplitude according to Hofstetter's formula: 15 - 0.25 x age. We also selected data from 40 consecutive subjects (control group) with no general binocular disorders and normal accommodative amplitudes. We studied the specificity and sensitivity of the four signs related with the accommodative insufficiency: high MEM dynamic retinoscopy, failing MAF and BAF with minus lenses of +/- 2 D flipper lenses, and low PRA.


RESULTS
Using the standard deviation as the cutoff, the specificity values were MEM = 0.88, MAF = 1, BAF = 0.93, and PRA = 1. When using the mean value as the cutoff, the specificity diminished, fundamentally for MEM. The sensitivity for the 41 patients using standard deviation as the cutoff was MEM = 0.44, MAF = 0.34, BAF = 0.27, and PRA = 0.27, and when using the mean value as the cutoff the four, sensitivity values increased.


CONCLUSIONS
According to the sensitivity results, with both cutoffs used, failing the +/- 2 D MAF test seems to be the sign that is most associated with the accommodative insufficiency.
Precoding for PAPR Reduction of OFDM Signals With Minimum Error Probability

The precoding technique is an effective and flexible way for reducing the peak-to-average power ratio (PAPR) of orthogonal frequency division multiplexing (OFDM) signals. However, different precoding schemes will increase error probabilities of the system. With the knowledge of the channel information and the receiver filter, we derive a necessary condition on the chosen precoding matrices for minimizing error probability of the OFDM system in the additive white Gaussian noise (AWGN) channel. A systematic procedure in designing such an optimal precoding matrix is provided. With a proper selection, the optimal precoding matrix can meet the requirements of PAPR reduction and achieve the minimum error probability in white Gaussian noise. Our simulation results show that the chosen precoding matrix notably outperforms other general precoding matrices in both AWGN and multipath fading channels. We also proved that the precoding matrix with all the singular values equal to 1 is one of the optimal solutions.
Effects of seated double-poling ergometer training on aerobic and mechanical power in individuals with spinal cord injury.

OBJECTIVE
To determine whether regular interval training on a seated double-poling ergometer can increase physical capacity and safely improve performance towards maximal level in individuals with spinal cord injury.


METHODS
A total of 13 subjects with spinal cord injury (injury levels T5-L1) performed 30 sessions of seated double-poling ergometer training over a period of 10 weeks. Sub-maximal and maximal double-poling ergometer tests were performed before (test-retest) and after this training period. Oxygen uptake was measured using the Douglas Bag system. Three-dimensional kinematics were recorded using an optoelectronic system and piezoelectric force sensors were used to register force in both poles.


RESULTS
The mean intra-class correlation coefficient for test-retest values was 0.83 (standard deviation 0.11). After training significant improvements were observed in people with spinal cord injury in oxygen uptake (22.7%), ventilation (20.7%) and blood lactate level (22.0%) during maximal exertion exercises. Mean power per stroke and peak pole force increased by 15.4% and 23.7%, respectively. At sub-maximal level, significantly lower values were observed in ventilation (-12.8%) and blood lactate level (-25.0%).


CONCLUSION
Regular interval training on the seated double-poling ergometer was effective for individuals with spinal cord injury below T5 level in terms of improving aerobic capacity and upper-body power output. The training was safe and did not cause any overload symptoms.
Supporting the moral development of medical students

Philosophers who studied moral development have found that individuals normally progress rapidly in early adulthood from a conventional stage in which they base behavior on the norms and values of those around them to a more principled stage where they identify and attempt to live by personal moral values. Available data suggest that many medical students, who should be in this transition, show little change in their moral development. Possibly, this relates to perceived pressures to conform to the informal culture of the medical wards. Many students experience considerable internal dissidence as they struggle to accommodate personal values related to empathy, care, and compassion to their clinical training. Educational interventions that positively influence this process have established regular opportunities for critical reflection by the students in small groups. Other interventions include faculty development to enhance role modeling and feedback by clinical faculty. The author espouses more widespread adoption of these educational interventions.
Proposed duplex velocity criteria for carotid restenosis following carotid endarterectomy with patch closure.

BACKGROUND
Duplex ultrasound velocity criteria have been used to evaluate the severity of carotid stenosis, however, these standard velocities may not be applicable to carotid restenosis after carotid endarterectomy (CEA) with patch angioplasty. The purpose of this study is to determine if patch angioplasty closure alters velocities just distal to CEA and to define the optimal velocities for detecting >or=30%, >or=50%, and >or=70% restenosis.


METHODS
This study includes 200 CEAs randomized into 100 with polytetrafluoroethylene (PTFE) ACUSEAL patch and 100 with Hemashield Finesse patch. All patients underwent immediate postoperative duplex ultrasounds, which were repeated at 1 month and every 6 months thereafter. Patients with a peak systolic velocity (PSV) of the internal carotid artery ([ICA], just distal to the patch) of >or=130 c/s underwent computed tomography angiogram (CTA). PSVs, end diastolic velocities (EDV), and internal carotid artery/common carotid artery (ICA/CCA) ratios were correlated to completion arteriograms/CTAs. Receiver operator characteristic curves analyses were used to determine optimal velocity criteria in detecting >or=30%, >or=50%, and >or=70% restenosis.


RESULTS
One hundred ninety-five pairs of imagings (duplex ultrasound vs CTA/angiogram) were available for analysis. When standard velocity criteria for nonoperated arteries were applied, 37% and 10% of patients were believed to have >or=50% to <70% and >or=70% to 99% restenosis vs 11.3% and 11.3% on CTA/angiography, respectively (P < .001). The mean PSV for >or=30%, >or=50%, and >or=70% restenosis were 172, 249, and 389 c/s, respectively (P < .001). An ICA PSV of >or=155c/s was optimal for >or=30% restenosis with sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and overall accuracy (OA) of 98%, 98%, 98%, 98%, and 98%, respectively. A PSV of >or=213 c/s was optimal for >or=50% restenosis with sensitivity, specificity, PPV, NPV, and OA of 99%, 100%, 100%, 98%, and 99%, respectively. An ICA PSV of 274 c/s was optimal for >or=70% restenosis with sensitivity, specificity, PPV, NPV, and OA of 99%, 91%, 99%, 91%, and 98%, respectively. ROC analysis showed that the PSVs were significantly better than EDVs and ICA/CCA ratios in detecting >or=30% and >or=50% restenosis.


CONCLUSIONS
The mean PSVs of a normal ICA distal to CEA patching were higher than normal nonoperated ICAs, therefore, standard duplex velocities criteria should be revised after CEA with patch closure.
Knowledge Discovery from Biomedical Ontologies in Cross Domains

In recent years, there is an increasing demand for sharing and integration of medical data in biomedical research. In order to improve a health care system, it is required to support the integration of data by facilitating semantic interoperability systems and practices. Semantic interoperability is difficult to achieve in these systems as the conceptual models underlying datasets are not fully exploited. In this paper, we propose a semantic framework, called Medical Knowledge Discovery and Data Mining (MedKDD), that aims to build a topic hierarchy and serve the semantic interoperability between different ontologies. For the purpose, we fully focus on the discovery of semantic patterns about the association of relations in the heterogeneous information network representing different types of objects and relationships in multiple biological ontologies and the creation of a topic hierarchy through the analysis of the discovered patterns. These patterns are used to cluster heterogeneous information networks into a set of smaller topic graphs in a hierarchical manner and then to conduct cross domain knowledge discovery from the multiple biological ontologies. Thus, patterns made a greater contribution in the knowledge discovery across multiple ontologies. We have demonstrated the cross domain knowledge discovery in the MedKDD framework using a case study with 9 primary biological ontologies from Bio2RDF and compared it with the cross domain query processing approach, namely SLAP. We have confirmed the effectiveness of the MedKDD framework in knowledge discovery from multiple medical ontologies.
Infectious etiology modifies the treatment effect of zinc in severe pneumonia.

BACKGROUND
Zinc is undergoing evaluation as an inexpensive therapeutic adjuvant for severe pediatric pneumonia.


OBJECTIVE
We explored the effect of etiology on the treatment effect of zinc in young children hospitalized for severe pneumonia.


DESIGN
We analyzed data from a randomized, double-blind, placebo-controlled clinical trial conducted at the Christian Medical College Hospital, a teaching hospital in Tamilnadu, India. Children aged 2-23 mo (n = 299) were randomly assigned to receive a 10-mg tablet of zinc sulfate or placebo twice a day during hospitalization. The primary outcomes were length of hospitalization and time to resolution of severe pneumonia stratified by etiologic classification on the basis of serum C-reactive protein (CRP) concentrations at admission.


RESULTS
CRP concentrations were available for 295 (98.7%) of the enrolled cases. Of these 295 cases, 223 (75.6%) were classified as suspected nonbacterial pneumonias (CRP concentrations <or=40 mg/L). Etiology modified the treatment effect of zinc on the length of the hospital stay [hazard ratio (HR) for interaction term: 0.52; 95% CI: 0.31, 0.91; P = 0.022]. In the 72 suspected bacterial cases (CRP concentrations >40 mg/L), the median length of hospitalization was approximately 20 h longer in the zinc-supplemented group than in the placebo group (87.3 and 68.3 h, respectively; HR: 0.56; 95% CI: 0.34, 0.93; P = 0.025). The treatment effect was not modified in the suspected nonbacterial cases of pneumonia.


CONCLUSIONS
Our results suggest that the treatment effect of zinc for severe pediatric pneumonia may be modified by bacterial infection. Further studies are required to develop appropriate recommendations for the use of zinc in the treatment of severe pneumonia. This trial was registered at clinicaltrials.gov as NCT00198666.
Research Article Differential Effects of Three Professional Development Models on Teacher Knowledge and Student Achievement in Elementary Science

To identify links among professional development, teacher knowledge, practice, and student achievement, researchers have called for study designs that allow causal inferences and that examine relationships among features of interventions and multiple outcomes. In a randomized experiment implemented in six states with over 270 elementary teachers and 7,000 students, this project compared three related but systematically varied teacher interventions—Teaching Cases, Looking at Student Work, and Metacognitive Analysis—along with no-treatment controls. The three courses contained identical science content components, but differed in the ways they incorporated analysis of learner thinking and of teaching, making it possible to measure effects of these features on teacher and student outcomes. Interventions were delivered by staff developers trained to lead the teacher courses in their regions. Each course improved teachers’ and students’ scores on selected-response science tests well beyond those of controls, and effects were maintained a year later. Student achievement also improved significantly for English language learners in both the study year and follow-up, and treatment effects did not differ based on sex or race/ethnicity. However, only Teaching Cases and Looking at Student Work courses improved the accuracy and completeness of students’ written justifications of test answers in the follow-up, and only Teaching Cases had sustained effects on teachers’ written justifications. Thus, the content component in common across the three courses had powerful effects on teachers’ and students’ ability to choose correct test answers, but their ability to explain why answers were correct only improved when the professional development incorporated analysis of student conceptual understandings and implications for instruction; metacognitive analysis of teachers’ own learning did not improve student justifications either year. Findings suggest investing in professional development that integrates content learning with analysis of student learning and teaching rather than advanced content or teacher metacognition alone. 2012 Wiley Periodicals, Inc. J Res Sci Teach 49: 333–362, 2012
The absolute bioavailability of oral vinorelbine in patients with solid tumors

Due to advances in the methods used to quantitate vinorelbine, this study was conducted to characterize fully the bioavailability of an oral dosage form of vinorelbine. Twenty-seven eligible patients with solid tumors were enrolled onto this study and were treated in a randomized crossover design to receive either 70 mg/m2 orally or 30 mg/m2 intravenously followed by the alternative treatment one week later. Vinorelbine was administered orally as a soft-gelatin capsule. Pharmacokinetic sampling was carried out for 7 days following each dose. Whole blood vinorelbine concentrations were measured using a sensitive LC/MS/MS method. The data from patients were excluded if they vomited within 3 h after the oral dose. Results: Three subjects were removed from study following the first dose due to safety reasons. Of the remaining 24 subjects, five experienced vomiting within 3 h of oral dosing. Total body clearance calculated from the intravenous dose was 43.65 L/h (±10.9) and the terminal half-life was estimated to be 49 h. Using complete data from the remaining 19 subjects, the mean absolute bioavailability of the oral dosage formulation of vinorelbine was calculated to be 33% (±18%). In conclusion we have characterized the pharmacokinetics of both orally administered and intravenous vinorelbine over 7 days after administration and have determined the mean oral bioavailability of this oral formulation to be 33%.
Evaluating Management Decisions via Delegation

A central problem of network management is compressing vast amounts of real-time operational data to accomplish management decisions. A health function provides such eecient compression by combining managed data linearly into a single index of network state. This paper describes a computational theory of network behaviors, their observations, and threshold-decisions via health functions. The model is used to examine feasibility of various methods for computing health functions. Health functions cannot be included as part of a static MIB design, as they may vary from site to site and over time. Nor can they be usefully computed at centralized management platforms , since this can result in excessive polling rates, lead to errors due to perturbation introduced by polling, and miss the very goal of compressing data maximally at its source. Instead, we propose the use of the management by delegation paradigm to support exible and effective evaluation of health functions and linear threshold decisions at devices.
Blockchain Transaction Processing

A blockchain is a linked-list of immutable tamper-proof blocks, which is stored at each participating node. Each block records a set of transactions and the associated metadata. Blockchain transactions act on the identical ledger data stored at each node. Blockchain was first perceived by Satoshi Nakamoto (Satoshi 2008), as a peer-to-peer money exchange system. Nakamoto referred to the transactional tokens exchanged among clients in his system, as Bitcoins. Overview
WEBSOM - Self-organizing maps of document collections

With the WEBSOM method a textual document collection may be organized onto a graphical map display that provides an overview of the collection and facilitates interactive browsing. Interesting documents can be located on the map using a content-directed search. Each document is encoded as a histogram of word categories which are formed by the self-organizing map (SOM) algorithm based on the similarities in the contexts of the words. The encoded documents are organized on another self-organizing map, a document map, on which nearby locations contain similar documents. Special consideration is given to the computation of very large document maps which is possible with general-purpose computers if the dimensionality of the word category histograms is first reduced with a random mapping method and if computationally efficient algorithms are used in computing the SOMs. ( 1998 Elsevier Science B.V. All rights reserved.