LLukas22/scidocs huggingface dataset:
"It depends": viewpoints of patients, physicians, and nurses on patient-practitioner prayer in the setting of advanced cancer.

CONTEXT
Although prayer potentially serves as an important practice in offering religious/spiritual support, its role in the clinical setting remains disputed. Few data exist to guide the role of patient-practitioner prayer in the setting of advanced illness.


OBJECTIVES
To inform the role of prayer in the setting of life-threatening illness, this study used mixed quantitative-qualitative methods to describe the viewpoints expressed by patients with advanced cancer, oncology nurses, and oncology physicians concerning the appropriateness of clinician prayer.


METHODS
This is a cross-sectional, multisite, mixed-methods study of advanced cancer patients (n=70), oncology physicians (n=206), and oncology nurses (n=115). Semistructured interviews were used to assess respondents' attitudes toward the appropriate role of prayer in the context of advanced cancer. Theme extraction was performed based on interdisciplinary input using grounded theory.


RESULTS
Most advanced cancer patients (71%), nurses (83%), and physicians (65%) reported that patient-initiated patient-practitioner prayer was at least occasionally appropriate. Furthermore, clinician prayer was viewed as at least occasionally appropriate by the majority of patients (64%), nurses (76%), and physicians (59%). Of those patients who could envision themselves asking their physician or nurse for prayer (61%), 86% would find this form of prayer spiritually supportive. Most patients (80%) viewed practitioner-initiated prayer as spiritually supportive. Open-ended responses regarding the appropriateness of patient-practitioner prayer in the advanced cancer setting revealed six themes shaping respondents' viewpoints: necessary conditions for prayer, potential benefits of prayer, critical attitudes toward prayer, positive attitudes toward prayer, potential negative consequences of prayer, and prayer alternatives.


CONCLUSION
Most patients and practitioners view patient-practitioner prayer as at least occasionally appropriate in the advanced cancer setting, and most patients view prayer as spiritually supportive. However, the appropriateness of patient-practitioner prayer is case specific, requiring consideration of multiple factors.
Effect of Ischemic Postconditioning on Infarct Size in Patients With ST‐Elevation Myocardial Infarction Treated by Primary PCI Results of the POSTEMI (POstconditioning in ST‐Elevation Myocardial Infarction) Randomized Trial

BACKGROUND
Reduction of infarct size by ischemic postconditioning (IPost) has been reported in smaller proof-of-concept clinical studies, but has not been confirmed in other smaller studies. The principle needs to be evaluated in larger groups of ST-elevation myocardial infarction (STEMI) patients before being implemented in clinical practice. This study assessed the effect of ischemic postcoditioning (IPost) on infarct size in patients with STEMI treated by primary percutaneous coronary intervention (PCI).


METHODS AND RESULTS
Patients with first-time STEMI, <6 hours from symptom onset, referred to primary PCI were randomized to IPost or control groups. IPost was administered by 4 cycles of 1-minute reocclusion and 1-minute reperfusion, starting 1 minute after opening, followed by stenting. In the control group, stenting was performed immediately after reperfusion. The primary endpoint was infarct size measured by cardiac magnetic resonance after 4 months. A total of 272 patients were randomized. Infarct size (percent of left ventricular mass) after 4 months (median values and interquartile range) was 14.4% (7.7, 24.6) and 13.5% (8.1, 19.3) in the control group and IPost group, respectively (P=0.18). No significant impact of IPost was found when controlling for baseline risk factors of infarct size in a multivariate linear regression model (P=0.16). The effects of IPost on secondary endpoints, including markers of necrosis, myocardial salvage, and ejection fraction, as well as adverse cardiac events during follow-up, were consistently neutral.


CONCLUSIONS
In contrast to several smaller trials reported previously, we found no significant effects of IPost on infarct size or secondary study outcomes.


CLINICAL TRIAL REGISTRATION URL
http://www.clinicaltrials.gov Unique identifier: NCT.No.PO1506.
Large Area 3-D Reconstructions From Underwater Optical Surveys

Robotic underwater vehicles are regularly performing vast optical surveys of the ocean floor. Scientists value these surveys since optical images offer high levels of detail and are easily interpreted by humans. Unfortunately, the coverage of a single image is limited by absorption and backscatter while what is generally desired is an overall view of the survey area. Recent works on underwater mosaics assume planar scenes and are applicable only to situations without much relief. We present a complete and validated system for processing optical images acquired from an underwater robotic vehicle to form a 3D reconstruction of the ocean floor. Our approach is designed for the most general conditions of wide-baseline imagery (low overlap and presence of significant 3D structure) and scales to hundreds or thousands of images. We only assume a calibrated camera system and a vehicle with uncertain and possibly drifting pose information (e.g., a compass, depth sensor, and a Doppler velocity log). Our approach is based on a combination of techniques from computer vision, photogrammetry, and robotics. We use a local to global approach to structure from motion, aided by the navigation sensors on the vehicle to generate 3D sub-maps. These sub-maps are then placed in a common reference frame that is refined by matching overlapping sub-maps. The final stage of processing is a bundle adjustment that provides the 3D structure, camera poses, and uncertainty estimates in a consistent reference frame. We present results with ground truth for structure as well as results from an oceanographic survey over a coral reef.
Impact of a novel, extended approach of perineal radical prostatectomy on surgical margins in localized prostate cancer.

STUDY TYPE
Therapy (case series) Level of Evidence 4.


OBJECTIVE
To validate the rationale of extended perineal radical prostatectomy (ePRP) for treating localized prostate cancer.


PATIENTS AND METHODS
Between December 2000 and May 2007, 196 patients with localized prostate cancer underwent PRP, among which 91 and 105 patients were treated with conventional PRP (cPRP) and ePRP, respectively. The apex, middle, base, and anterior regions of the prostate were separately analysed, and the focus of analysis was on the distribution, size, Gleason score, and positive surgical margins (PSMs) of prostate cancer foci.


RESULTS
The operation time was significantly shorter in ePRP compared with cPRP (161 min vs 188 min; P= 0.001), while there was no significant difference in estimated blood loss between cPRP and ePRP (550 mL vs 500 mL). At the apex and base, there was no significant difference in the PSM rate between cPRP and ePRP. In the middle, there was a lower incidence of PSMs in ePRP (2.4%) than in cPRP (10.9%; P= 0.009). On the anterior side, PSMs were more frequent in cPRP (21.6%) than in ePRP (7.1%; P= 0.029). Logistic regression analysis adjusted by PSA level showed that PSM rate was the most significantly affected by the surgical approach.


CONCLUSION
We think that ePRP provides an effective treatment strategy for localized prostate cancer in light of excellent cancer control and minimum potential of surgical invasiveness.
Validation of plasma proneurotensin as a novel biomarker for the prediction of incident breast cancer.

BACKGROUND
High fasting plasma proneurotensin concentration was associated with the development of breast cancer in the Malmö Diet and Cancer Study (MDCS). Here, we aimed at replicating the initial finding in an independent second cohort.


METHODS
The Malmö Preventive Project (MPP) is a population study and comprised 18,240 subjects when examined in 2002-2006. Of women without history of breast cancer at examination, we included all who developed breast cancer during follow-up (n = 130) until December 31, 2010, and a random sample of women without breast cancer until the end of follow-up (n = 1,439) for baseline plasma proneurotensin assessment (mean age, 70.0 ± 4.4 years). Proneurotensin was measured in fasting plasma samples and was related to the risk of later breast cancer development using multivariate logistic regression.


RESULTS
Proneurotensin [odds ratio (OR) per standard deviation (SD) increment of LN-transformed proneurotensin] was significantly related to incident breast cancer [OR, 2.09; 95% confidence interval (CI), 1.79-2.44; P < 0.001; adjusted for age, body mass index (BMI), smoking, and hormone replacement therapy]. The effect estimate in the MPP was larger than in the discovery cohort (MDCS), with the main difference between the two cohorts being that women of the MPP study were on the average about 10 years older and follow-up time was shorter than that of the MDCS.


CONCLUSION
As initially found in the MDCS, fasting plasma proneurotensin was significantly associated with the development of breast cancer in the MPP study as well.


IMPACT
Measurement of plasma proneurotensin warrants further investigation as a blood-based marker for early breast cancer detection.
Social Security and Institutions for Intergenerational , Intragenerational and International Risk Sharing

Social security system old age insurance systems are devices for the sharing of income risks of elderly people with others. Risks can be shared intergenerationally (with the young of the same country), intragenerationally (with other elderly of the same country) or internationally (with foreigners). Barriers to individuals themselves sharing their risks intergenerationally, intragenerationally or internationally are described. Optimal design of government-sponsored social security systems is considered in light of these barriers. Alternative benefits and contributions formulas for pay-as-you-go social security systems are defined and compared with existing and proposed formulas in terms of their ability to fulfill the government’s role in promoting risk sharing. Benefits for each retired person may be tied to that person’s lifetime income without causing (as with the US benefits formula today) aggregate benefits for all elderly today to be tied to their past aggregate income.
[Development of an algorithm to predict the incidence of major depression among primary care consultants].

BACKGROUND
The reduction of major depression incidence is a public health challenge.


AIM
To develop an algorithm to estimate the risk of occurrence of major depression in patients attending primary health centers (PHC).


MATERIAL AND METHODS
Prospective cohort study of a random sample of 2832 patients attending PHC centers in Concepción, Chile, with evaluations at baseline, six and twelve months. Thirty nine known risk factors for depression were measured to build a model, using a logistic regression. The algorithm was developed in 2,133 patients not depressed at baseline and compared with risk algorithms developed in a sample of 5,216 European primary care attenders. The main outcome was the incidence of major depression in the follow-up period.


RESULTS
The cumulative incidence of depression during the 12 months follow up in Chile was 12%. Eight variables were identified. Four corresponded to the patient (gender, age, depression background and educational level) and four to patients' current situation (physical and mental health, satisfaction with their situation at home and satisfaction with the relationship with their partner). The C-Index, used to assess the discriminating power of the final model, was 0.746 (95% confidence intervals (CI = 0,707-0,785), slightly lower than the equation obtained in European (0.790 95% CI = 0.767-0.813) and Spanish attenders (0.82; 95% CI = 0.79-0.84).


CONCLUSIONS
Four of the factors identified in the risk algorithm are not modifiable. The other two factors are directly associated with the primary support network (family and partner). This risk algorithm for the incidence of major depression provides a tool that can guide efforts towards design, implementation and evaluation of effectiveness of interventions to prevent major depression.
Mining Potential Domain Expertise in Pinterest

This paper describes a first investigation of potential domain expertise in Pinterest. We introduce measures for characterizing the volume and coherence of Pinterest users’ pinning activity in a given category, their perceived and declared category-specific expertise and the response from the social network. We use such signals in the context of a supervised ML framework and report encouraging preliminary results on the task of mining potential experts for 4 popular content categories.
The test of functional health literacy in adults

OBJECTIVE: To develop a valid, reliable instrument to measure the functional health literacy of patients. DESIGN: The Test of Functional Health Literacy in Adults (TOFHLA) was developed using actual hospital materials. The TOFHLA consists of a 50-item reading comprehension and 17-item numerical ability test, taking up to 22 minutes to administer. The TOFHLA, the Wide Range Achievement Test-Revised (WRAT-R), and the Rapid Estimate of Adult Literacy in Medicine (REALM) were administered for comparison. A Spanish version was also developed (TOFHLA-S). SETTING: Outpatient settings in two public teaching hospitals. PATIENTS: 256 English- and 249 Spanish-speaking patients were approached. 78% of the English- and 82% of the Spanish-speaking patients gave informed consent, completed a demographic survey, and took the TOFHLA or TOFHLA-S. RESULTS: The TOFHLA showed good correlation with the WRAT-R and the REALM (correlation coefficients 0.74 and 0.84, respectively). Only 52% of the English speakers completed more than 80% of the questions correctly. 15% of the patients could not read and interpret a prescription bottle with instructions to take one pill by mouth four times daily, 37% did not understand instructions to take a medication on an empty stomach, and 48% could not determine whether they were eligible for free care. CONCLUSIONS: The TOFHLA is a valid, reliable indicator of patient ability to read health-related materials. Data suggest that a high proportion of patients cannot perform basic reading tasks. Additional work is needed to determine the prevalence of functional health illiteracy and its effect on the health care experience.
Uniform Electric Field Distribution in Microwave Heating Applicators by Means of Genetic Algorithms Optimization of Dielectric Multilayer Structures

In this paper, the design of a dielectric multilayer around a clay sample is presented to achieve a uniform electric field distribution over that sample. This structure is located within a multimode microwave-heating oven and is designed by means of genetic algorithms. The permittivity and geometric values for the sample surrounding layers are the selected parameters to be optimized in order to minimize the ratio between the typical deviation and the absolute value of the electric field. The results demonstrate the improvement of the electric field uniformity over the sample using dielectric layers
Identification of diagnostic subtypes of chronic pelvic pain and how subtypes differ in health status and trauma history.

OBJECTIVE
Our primary aim was to identify subtypes of chronic pelvic pain and to compare the cases of women with the identified subtypes on health status and trauma history. We hypothesized that women with diffuse abdominal/pelvic pain would have greater health impairment and report more lifetime trauma than women with vulvovaginal pain or cyclic pain.


STUDY DESIGN
We collected questionnaire data on 289 consecutive women patients from a university chronic pelvic pain clinic. From patient records, 1 gynecologist identified chronic pelvic pain subtypes on the basis of reported symptoms and the localization of pain during examination. We used analysis of covariance with pairwise contrasts.


RESULTS
Seven diagnostic subtypes were identified. Patients with diffuse abdominal/pelvic pain had more trauma and worse mental and physical health status compared with patients with vulvovaginal pain and cyclic pain. Those patients with abdominal/pelvic pain also had poorer health than patients with neuropathic and fibroid pain. Endometriosis was unrelated to health status.


CONCLUSION
There is immense need for further research to define subtypes of chronic pelvic pain.
The influence of genetic factors and life stress on depression among adolescent girls.

BACKGROUND
The possible causes of greater depression among adolescent girls were investigated by examining variation in the influence of genetic and environmental risk factors among 182 prepubertal female, 237 prepubertal male, 314 pubertal female, and 171 pubertal male twin pairs from the Virginia Twin Study of Adolescent Behavioral Development.


OBJECTIVES
To compare the trajectory of depressive symptoms among boys and girls from childhood to adolescence; to analyze the role of genetic, shared, and unique environmental factors in depression among prepubertal and pubertal male and female twins; and to investigate a possible link between liability to depression and one salient index of the child's environment: past-year life events.


METHODS
Child-reported depression was assessed using the Child and Adolescent Psychiatric Interview and ratings of past-year life events and pubertal status obtained by maternal questionnaire and interview, respectively.


RESULTS
The impact of life events on depression was particularly evident in the adolescent girls. The results from model fitting indicate increased heritability for depression in this group, and its long-term consistency was mediated primarily by latent genetic factors. Model fitting also showed that at least part of the liability to depression and to life events can be linked to a common set of genes in the adolescent girls, and there is a notable developmental increase in the genetic variance for life events.


CONCLUSIONS
The greater heritability for depression in pubertal girls, its genetic mediation over time, and the increase in genetic variance for life events may be one possible explanation for the emergence of increased depression among pubertal girls and its persistence through adolescence.
Intermediation in a Sharing Economy: Insurance, Moral Hazard, and Rent Extraction

Electronic intermediaries have become pervasive in sales transactions for many durables, such as cars, power tools, and apartments. Yet only recently have they successfully tackled the challenge of enabling parties to share such goods. A key impediment to sharing is a lender’s concern about damage due to unobservable actions by a renter, usually resulting in moral hazard. This paper shows how an intermediary can eliminate the moral-hazard problem by providing optimal insurance to the lender and first-best-incentives to the renter to exert care, as long as market participants are risk-neutral. The solution is illustrated for the collaborative housing market but applies in principle to any sharing market with vertically differentiated goods. A population of renters, heterogeneous both in their preferences for housing quality and with respect to the amounts of care they exert in a rental situation, faces a choice between collaborative housing and staying at a local hotel. The private hosts choose their prices strategically and the intermediary sets commission rates on both sides of the market as well as insurance terms for the rental agreement. The latter are set so as to eliminate moral hazard. The intermediary is able to extract the gains the hosts would earn compared to transacting directly. Finally, even if hotels set their prices at the outset so as to maximize collusive profits, we find that collaborative housing persists at substantial market shares, regardless of the difference between the efficiencies of hosts and hotels to reduce renters’ cost of effort. The aggregate of hosts, intermediary, and hotels benefits from (a variety in) these effort costs, which indicates that the intermediated sharing of goods is an economically viable, robust phenomenon. JEL-Classification: C72, D43, D47, L13, L14, O18, R31.
Requisite Variety, Autopoiesis, and Self-organization

Purpose – Autopoiesis is a concept originally used to define living systems. However, no measure for autopoiesis has been proposed so far. Moreover, how can we build systems with a higher autopoiesis value? The paper aims to discuss these issues. Design/methodology/approach – Relating autopoiesis with Ashby’s law of requisite variety, self-organization is put forward as a way in which systems can be designed to match the variety of their environment. Findings – Guided self-organization has been shown to produce systems which can adapt to the requisite variety of their environment, offering more efficient solutions for problems that change in time than those obtained with traditional techniques. Originality/value – Being able to measure autopoiesis allows us to apply this measure to all systems. More “living” systems will be fitter to survive in their environments: biological, social, technological, or urban.
Emotion work and psychological well-being A review of the literature and some conceptual considerations

In this article, the state of the art of research on emotion work (emotional labor) is summarized with an emphasis on its effects on well-being. It starts with a definition of what emotional labor or emotion work is. Aspects of emotion work, such as automatic emotion regulation, surface acting, and deep acting, are discussed from an action theory point of view. Empirical studies so far show that emotion work has both positive and negative effects on health. Negative effects were found for emotional dissonance. Concepts related to the frequency of emotion expression and the requirement to be sensitive to the emotions of others had both positive and negative effects. Control and social support moderate relations between emotion work variables and burnout and job satisfaction. Moreover, there is empirical evidence that the cooccurrence of emotion work and organizational problems leads to high levels of burnout. D 2002 Published by Elsevier Science Inc.
Quantum computation in brain microtubules? The Penrose-Hameroff 'Orch OR' model of consciousness

Potential features of quantum computation could explain enigmatic aspects of consciousness. The Penrose–Hameroff model (orchestrated objective reduction: ‘Orch OR’) suggests that quantum superposition and a form of quantum computation occur in microtubules—cylindrical protein lattices of the cell cytoskeleton within the brain’s neurons. Microtubules couple to and regulate neural-level synaptic functions, and they may be ideal quantum computers because of dynamical lattice structure, quantum-level subunit states and intermittent isolation from environmental interactions. In addition to its biological setting, the Orch OR proposal differs in an essential way from technologically envisioned quantum computers in which collapse, or reduction to classical output states, is caused by environmental decoherence (hence introducing randomness). In the Orch OR proposal, reduction of microtubule quantum superposition to classical output states occurs by an objective factor—Roger Penrose’s quantum gravity threshold stemming from instability in Planck-scale separations (superpositions) in spacetime geometry. Output states following Penrose’s objective reduction are neither totally deterministic nor random, but influenced by a non-computable factor ingrained in fundamental spacetime. Taking a modern panpsychist view in which protoconscious experience and Platonic values are embedded in Planck-scale spin networks, the Orch OR model portrays consciousness as brain activities linked to fundamental ripples in spacetime geometry.