LLukas22/scidocs huggingface dataset:
Ultrasonographically determined pedicled breast reduction in severe gigantomastia.

BACKGROUND
The free nipple breast reduction method has certain disadvantages, such as nipple hyposensitivity, loss of lactation, and loss of projection. To eliminate these risks, the authors describe a patient-based breast reduction technique in which the major supplier vessels of the nipple-areola complex were determined by color Doppler ultrasonography. Pedicles containing these vessels were designed for reductions.


METHODS
Sixteen severe gigantomastia patients with a mean age of 41 years (range, 23 to 60 years) were included in the study. Major nipple-areola complex perforators were determined with 13- to 5-MHz linear probe Doppler ultrasonography before surgery. Pedicles were designed according to the vessel locations, and reductions were performed with superomedial-, superolateral-, or mediolateral-based designs.


RESULTS
Different combinations of internal mammary and lateral thoracic artery perforator-based reductions were achieved. None of the patients had areola necrosis. Mean reduction weight was 1795 g (range, 1320 to 2280) per breast.


CONCLUSIONS
Instead of using standard markings for severe gigantomastia patients, custom-made and sonographically determined pedicles were used. This technique can be considered as a "guide" for the surgeon during very large breast reductions.
Aquaporin 5 Polymorphisms and Rate of Lung Function Decline in Chronic Obstructive Pulmonary Disease

RATIONALE
Aquaporin-5 (AQP5) can cause mucus overproduction and lower lung function. Genetic variants in the AQP5 gene might be associated with rate of lung function decline in chronic obstructive pulmonary disease (COPD).


METHODS
Five single nucleotide polymorphisms (SNPs) in AQP5 were genotyped in 429 European American individuals with COPD randomly selected from the NHLBI Lung Health Study. Mean annual decline in FEV(1) % predicted, assessed over five years, was calculated as a linear regression slope, adjusting for potential covariates and stratified by smoking status. Constructs containing the wildtype allele and risk allele of the coding SNP N228K were generated using site-directed mutagenesis, and transfected into HBE-16 (human bronchial epithelial cell line). AQP5 abundance and localization were assessed by immunoblots and confocal immunofluorescence under control, shear stress and cigarette smoke extract (CSE 10%) exposed conditions to test for differential expression or localization.


RESULTS
Among continuous smokers, three of the five SNPs tested showed significant associations (0.02>P>0.004) with rate of lung function decline; no associations were observed among the group of intermittent or former smokers. Haplotype tests revealed multiple association signals (0.012>P>0.0008) consistent with the single-SNP results. In HBE16 cells, shear stress and CSE led to a decrease in AQP5 abundance in the wild-type, but not in the N228K AQP5 plasmid.


CONCLUSIONS
Polymorphisms in AQP5 were associated with rate of lung function decline in continuous smokers with COPD. A missense mutation modulates AQP-5 expression in response to cigarette smoke extract and shear stress. These results suggest that AQP5 may be an important candidate gene for COPD.
In vitro biomechanical comparison of a plate-rod combination-construct and an interlocking nail-construct for experimentally induced gap fractures in canine tibiae.

OBJECTIVE
To compare structural properties of a plate-rod combination-bone construct (PRCbc) and interlocking nail-bone construct (ILNbc) by use of an experimentally induced gap fracture in canine tibiae.


SAMPLE POPULATION
12 paired canine tibiae.


PROCEDURE
Specimens were implanted with a plate-rod combination consisting of a 3.5-mm, limited-contact, dynamic-compression plate combined with an intramedullary rod or 6-mm interlocking nail. Ostectomy (removal of 10-mm segment) was performed. Paired constructs were loaded for bending, compression, or torsion measurements (4 constructs/group). Compliance was determined by fitting regression lines to the load-position curves at low (initial compliance) and high (terminal compliance) loads.


RESULTS
Bending compliances did not differ significantly between constructs. For the ILNbc, initial compliance was greater than terminal compliance in compression and torsion. Initial compliance and terminal compliance for the PRCbc were similar in compression and torsion. Initial compliance in compression and torsion was greater for the ILNbc, compared with initial compliance for the PRCbc. Maximum deformations in bending and compression were similar between constructs; however, maximum torsional angle was significantly greater for the ILNbc, compared with values for the PRCbc.


CONCLUSIONS AND CLINICAL RELEVANCE
The study documented that for an experimentally induced gap fracture in canine tibiae, a plate-rod combination is a significantly less compliant fixation method in torsion and compression, compared with an interlocking nail. Considering the deleterious effects of torsional deformation on bone healing, a plate-rod combination may represent a biomechanically superior fixation method, compared with an interlocking nail, for the treatment of dogs with comminuted tibial diaphyseal fractures.
COMPACT TRIPLE-FREQUENCY SLOT ANTENNA FOR WLAN/WIMAX OPERATIONS

A novel microstrip-fed slot antenna with triple-band operation in compact size is proposed. The proposed antenna structure consists of a L-shaped microstrip feed line and open-ended slot on the ground plane, having small overall size of 14 × 34mm2. The openended slot constructed of crossed double T-shaped slots is aimed to obtain resonant modes at 2.4/3.5 GHz. Meanwhile, with the use of a via-loaded metal patch connected to the edge of ground, the upper resonant frequency point at 5.8GHz is achieved. The numerical and experimental results exhibit the designed antenna operates over triple frequency ranges, fulfilling the standards of 3.5-GHz WiMAX and 2.4/5.8-GHz WLAN. In addition, acceptable radiation characteristic is obtained over the operating bands.
[Iliopsoas abscess: therapeutic approach and outcome in a series of 35 patients].

INTRODUCTION
The present study was aimed at reviewing the iliopsoas abscess (IPA) from a contemporary perspective, on the basis of experience from two tertiary referral centres.


MATERIAL AND METHODS
We performed a retrospective analysis of 35 cases of IPA diagnosed between 1998 and 2009. Their clinical and microbiological features were recorded, as well as their long-term outcome according to the type of treatment: antibiotics alone (10 patients), or antibiotics plus percutaneous drainage or surgery (25 patients).


RESULTS
Primary abscess occurred in 8 patients. The most frequent source of secondary abscesses was spondylodiscitis. The classic clinical triad (fever, pain and functional impairment) was present in 10 patients, with a median duration of symptoms before diagnosis of 12 days. Staphylococcus aureus was the most frequently isolated microorganism. At the end of a median follow-up of 454 days, the risk of poor outcome (related death and/or relapse) was higher among patients with diabetes mellitus (44.4% vs. 7.7%; P=.027), with no significant differences according to the therapeutic approach (20.0% in the group of antibiotics alone vs. 28.0% in the group with drainage or surgery).


CONCLUSIONS
In our series, most cases of IPA were due to S. aureus and secondary to a skeletal source. Antibiotic therapy seems effective in the long-term, although diabetic patients had a higher risk of relapse.
Graph-Based Inverse Optimal Control for Robot Manipulation

Inverse optimal control (IOC) is a powerful approach for learning robotic controllers from demonstration that estimates a cost function which rationalizes demonstrated control trajectories. Unfortunately, its applicability is difficult in settings where optimal control can only be solved approximately. While local IOC approaches have been shown to successfully learn cost functions in such settings, they rely on the availability of good reference trajectories, which might not be available at test time. We address the problem of using IOC in these computationally challenging control tasks by using a graph-based discretization of the trajectory space. Our approach projects continuous demonstrations onto this discrete graph, where a cost function can be tractably learned via IOC. Discrete control trajectories from the graph are then projected back to the original space and locally optimized using the learned cost function. We demonstrate the effectiveness of the approach with experiments conducted on two 7-degree of freedom robotic arms.
Machine vision: a survey

This paper surveys the field of machine vision from a computer science perspective. It is written to act as an introduction to the field and presents the reader with references to specific implementations. Machine vision is a complex and developing field that can be broken into the three stages: stereo correspondence, scene reconstruction, and object recognition. We present the techniques and general approaches to each of these stages and summarize the future direction of research.
Current evidence and future directions for research with omega-3 fatty acids and attention deficit hyperactivity disorder.

PURPOSE OF REVIEW
Nutritional insufficiencies of nutrients such as omega-3 highly unsaturated fatty acids (HUFAs), vitamins and minerals have been linked to suboptimal developmental outcomes including attention deficit hyperactivity disorder (ADHD). Although the predominant treatment is currently psychostimulant medications, randomized clinical trials with omega-3 HUFAs have reported small-to-modest effects in reducing symptoms of ADHD in children despite arguable individual methodological and design misgivings.


RECENT FINDINGS
This review presents, discusses and critically evaluates data and findings from meta-analytic and systematic reviews and clinical trials published within the last 12 months. Recent trajectories of this research are discussed, such as comparing eicosapentaenoic acid and docosahexaenoic acid and testing the efficacy of omega-3 HUFAs as an adjunct to methylphenidate. Discussion includes highlighting limitations and potential future directions such as addressing variable findings by accounting for other nutritional deficiencies and behavioural food intolerances.


SUMMARY
The authors conclude that given the current economic burden of ADHD, estimated in the region of $77 billion in the USA alone, in addition to the fact that a proportion of patients with ADHD are either treatment resistant, nonresponders or withdraw from medication because of adverse side-effects, the investigation of nonpharmacological interventions including omega-3 HUFAs in clinical practice warrants extrapolating.
Visual Twitter Analytics (Vista): Temporally changing sentiment and the discovery of emergent themes within sport event tweets

Purpose – Due to the size and velocity at which user generated content is created on social media services such as Twitter, analysts are often limited by the need to pre-determine the specific topics and themes they wish to follow. Visual analytics software may be used to support the interactive discovery of emergent themes. The paper aims to discuss these issues. Design/methodology/approach – Tweets collected from the live Twitter stream matching a user’s query are stored in a database, and classified based on their sentiment. The temporally changing sentiment is visualized, along with sparklines showing the distribution of the top terms, hashtags, user mentions, and authors in each of the positive, neutral, and negative classes. Interactive tools are provided to support sub-querying and the examination of emergent themes. Findings – A case study of using Vista to analyze sport fan engagement within a mega-sport event (2013 Le Tour de France) is provided. The authors illustrate how emergent themes can be identified and isolated from the large collection of data, without the need to identify these a priori. Originality/value – Vista provides mechanisms that support the interactive exploration among Twitter data. By combining automatic data processing and machine learning methods with interactive visualization software, researchers are relieved of tedious data processing tasks, and can focus on the analysis of high-level features of the data. In particular, patterns of Twitter use can be identified, emergent themes can be isolated, and purposeful samples of the data can be selected by the researcher for further analysis.
Phase I drug and light dose-escalation trial of motexafin lutetium and far red light activation (phototherapy) in subjects with coronary artery disease undergoing percutaneous coronary intervention and stent deployment: procedural and long-term results.

BACKGROUND
Motexafin lutetium (MLu; Antrin) is a photosensitizer that is taken up by atherosclerotic plaque and concentrated within macrophages and vascular smooth muscle cells. After photoactivation with far red light, MLu facilitates production of cytotoxic oxygen radicals that mediate apoptosis. We assessed the safety and tolerability of phototherapy (PT) with MLu in patients undergoing percutaneous coronary intervention with stent deployment.


METHODS AND RESULTS
An open-label, phase I, drug and light dose-escalation clinical trial of MLu PT enrolled 80 patients undergoing de novo coronary stent deployment. MLu was administered to 79 patients by intravenous infusion 18 to 24 hours before procedure, and photoactivation was performed after balloon predilatation and before stent deployment. Clinical evaluation, serial quantitative angiography, and intravascular ultrasound were performed periprocedurally and at 6 months follow-up. MLu PT was well tolerated without serious dose-limiting toxicities, and side effects (paresthesia and rash) were minor. No adverse angiographic outcomes were attributed to phototherapy.


CONCLUSIONS
This study demonstrates that coronary MLu PT seems safe, and the maximum well-tolerated MLu dose and range of tolerated light doses were identified. These data can be used in phase II efficacy trials of MLu PT for the treatment of coronary atherosclerosis or vulnerable plaque.
Training a Support Vector Machine in the Primal

Most literature on support vector machines (SVMs) concentrates on the dual optimization problem. In this letter, we point out that the primal problem can also be solved efficiently for both linear and nonlinear SVMs and that there is no reason for ignoring this possibility. On the contrary, from the primal point of view, new families of algorithms for large-scale SVM training can be investigated.
Microbiological safety of the first clinical pig islet xenotransplantation trial in New Zealand.

BACKGROUND
Xenotransplantation using pig cells, tissues, or organs may be associated with the transmission of porcine microorganisms and the development of zoonoses. Among all porcine microorganisms porcine endogenous retroviruses (PERVs) represent a special risk because they are integrated in the genome of all pigs and able to infect human cells. In previous preclinical and retrospective clinical trials of xenotransplantation, no transmission of PERV was observed. The first clinical trial of (alginate-encapsulated) porcine islet cell transplantation in New Zealand, which was approved by the New Zealand Government as an open-label phase I/IIa safety/efficacy trial, offers the possibility to analyze microbiological safety in a prospective clinical study.


METHODS
Before the trial started, a multilevel testing strategy was used to screen for 26 microorganisms in donor pigs of the Auckland Island strain and the islet cell preparations used for treatment. Donor testing was performed using molecular methods including multiplex real-time PCR. Blood samples from 14 pig islet cell recipients were also investigated by molecular biological methods at weeks 1, 4, 8, 12, 24, and 52 post-transplant for the transmission of porcine microorganisms. Sera were also monitored at these time points for antibodies against PERVs.


RESULTS
Beginning in 2009, fourteen patients with severe unaware hypoglycemia were treated with one of four different dosages of alginate-encapsulated porcine islets ranging from 5000-20,000 islet equivalents delivered in a single dose. No transmission of either PERVs or other porcine microorganisms was detected by PCR and immunological methods.


CONCLUSION
These findings support previous results and strongly indicate the safety of xenotransplantation as performed here.
Supplementation with 3 compositionally different tocotrienol supplements does not improve cardiovascular disease risk factors in men and women with hypercholesterolemia.

BACKGROUND
Tocotrienols have been reported to lower LDL-cholesterol and fasting glucose concentrations and to have potent antioxidant effects, but the results are contradictory.


OBJECTIVE
The objective was to study the relative effect of tocotrienol supplements of different compositions (mixed alpha- plus gamma-, high gamma-, or P25-complex tocotrienol) on blood lipids, fasting blood glucose, and the excretion of 8-iso-prostaglandin F(2alpha), a measure of oxidative stress, in healthy hypercholesterolemic men and women.


DESIGN
This was a double-blind, randomized, parallel-design study in which subjects (n = 67 men and women) consumed 1 of 3 commercially available tocotrienol supplements or a safflower oil placebo for 28 d. Blood and urine samples were obtained before and after the 28-d supplementation phase for analysis of fasting blood lipids, glucose, tocotrienols and tocopherols, and 8-iso-prostaglandin F(2alpha).


RESULTS
Overall, serum tocotrienols were increased in subjects who consumed tocotrienols, which showed that the putatively active components were absorbed. No significant differences in mean lipid or glucose concentrations were observed among the 4 treatment groups at the end of the 28-d supplementation phase. However, when the values were expressed as a percentage change from the concentrations during the presupplementation run-in phase, LDL cholesterol increased slightly (7 +/- 2%) but significantly (P < 0.05) in the group consuming the mixed alpha- plus gamma-tocotrienol supplement when compared with LDL cholesterol in the group consuming the P25-complex tocotrienol. Neither mean concentrations nor the percentage change in 8-iso-prostaglandin F(2alpha) differed significantly among treatments.


CONCLUSION
Supplementation with 200 mg tocotrienols/d from 3 commercially available sources has no beneficial effect on key cardiovascular disease risk factors in highly compliant adults with elevated blood lipid concentrations.
A Polarized Clustered Channel Model for Indoor Multiantenna Systems at 3.6 GHz

Multiple-input-multiple-output (MIMO) technologies allow high data rates to be obtained, but they suffer from interantenna correlation caused by the limits in interantenna spacing. Polarized MIMO systems resolve this problem by using colocated perpendicularly polarized antennas that have low interantenna correlation. In this paper, a polarized single-directional channel model for 2×N MIMO systems at 3.6 GHz in an indoor environment is presented. The wireless channel is modeled as a sum of clusters, where each cluster has specular and diffuse components. The polarization of the specular component of the clusters is included by considering a per-path polarization. The diffuse component of the clusters is modeled with a Fisher-Bingham (FB5) spectrum in the azimuth-coelevation domain and with an exponential power delay profile. Polarization is analyzed by introducing the cross-polar discrimination of the exponential power delay profile parameters. All of the parameters in the model are extracted from an experimental measurement campaign performed in an indoor environment at 3.6 GHz. Individual paths are extracted from the measurements with the space-alternating generalized expectation-maximization (SAGE) algorithm. These paths are grouped in clusters within the azimuth of arrival-elevation of arrival-delay domains at the receiver side using automatic clustering algorithms. The specular component properties of the clusters are then determined. Finally, the diffuse components of the clusters are investigated and parameterized by applying a beamforming algorithm on the diffuse part of the impulse response.
Can Inhomogeneities Accelerate the Cosmic Volume Expansion

If expanding and contracting regions coexist in the universe, the speed of the cosmic volume expansion can be accelerated. We construct simple inhomogeneous dust-filled universe models in which the speed of the cosmic volume expansion is accelerated for finite periods. These models are constructed by removing spherical domains from the Einstein-de Sitter �
Development of Gaussian Minimum Shift Keying ( GMSK ) Demodulator for Satellite Communication A

ISSN 2277 5080 | © 2012 Bonfring Abstract--This paper discusses DSP based implementation of Gaussian Minimum Shift Keying (GMSK) demodulator using Polarity type Costas loop. The demodulator consists of a Polarity type Costas loop for carrier recovery, data recovery, and phase detection. Carrier has been recovered using a loop of center-frequency locking scheme as in M-ary Phase Shift Keying (MPSK) Polarity type Costas-loop. Phase unwrapping and Bit-Reconstruction is presented in detail. All the modules are first modeled in MATLAB (Simulink) and Systemview. After bit true simulation, the design is coded in VHDL and code simulation is done using QuestaSim 6.3c. The design is targeted to Virtex-4 XC4VSX35-10FF668 Xilinx FPGA (Field programmable gate array) for real time testing, which is carried out on Xtreme DSP development platform.
Design and Simulation of Low Noise Amplifier Circuit for 5 GHz to 6 GHz

In first stage of each microwave receiver there is Low Noise Amplifier (LNA) circuit, and this stage has important rule in quality factor of the receiver. The design of a LNA in Radio Frequency (RF) circuit requires the trade-off many importance characteristics such as gain, Noise Figure (NF), stability, power consumption and complexity. This situation Forces desingners to make choices in the desing of RF circuits. In this paper the aim is to design and simulate a single stage LNA circuit with high gain and low noise using MESFET for frequency range of 5 GHz to 6 GHz. The desing simulation process is down using Advance Design System (ADS). A single stage LNA has successfully designed with 15.83 dB forward gain and 1.26 dB noise figure in frequency of 5.3 GHz. Also the designed LNA should be working stably In a frequency range of 5 GHz to 6 GHz. Keywords—Advance Design System, Low Noise Amplifier, Radio Frequency, Noise Figure.