LLukas22/scidocs huggingface dataset:
Pandemics in the Age of Twitter: Content Analysis of Tweets during the 2009 H1N1 Outbreak

BACKGROUND
Surveys are popular methods to measure public perceptions in emergencies but can be costly and time consuming. We suggest and evaluate a complementary "infoveillance" approach using Twitter during the 2009 H1N1 pandemic. Our study aimed to: 1) monitor the use of the terms "H1N1" versus "swine flu" over time; 2) conduct a content analysis of "tweets"; and 3) validate Twitter as a real-time content, sentiment, and public attention trend-tracking tool.


METHODOLOGY/PRINCIPAL FINDINGS
Between May 1 and December 31, 2009, we archived over 2 million Twitter posts containing keywords "swine flu," "swineflu," and/or "H1N1." using Infovigil, an infoveillance system. Tweets using "H1N1" increased from 8.8% to 40.5% (R(2) = .788; p<.001), indicating a gradual adoption of World Health Organization-recommended terminology. 5,395 tweets were randomly selected from 9 days, 4 weeks apart and coded using a tri-axial coding scheme. To track tweet content and to test the feasibility of automated coding, we created database queries for keywords and correlated these results with manual coding. Content analysis indicated resource-related posts were most commonly shared (52.6%). 4.5% of cases were identified as misinformation. News websites were the most popular sources (23.2%), while government and health agencies were linked only 1.5% of the time. 7/10 automated queries correlated with manual coding. Several Twitter activity peaks coincided with major news stories. Our results correlated well with H1N1 incidence data.


CONCLUSIONS
This study illustrates the potential of using social media to conduct "infodemiology" studies for public health. 2009 H1N1-related tweets were primarily used to disseminate information from credible sources, but were also a source of opinions and experiences. Tweets can be used for real-time content analysis and knowledge translation research, allowing health authorities to respond to public concerns.
A comparison of data warehousing methodologies

Using a common set of attributes to determine which methodology to use in a particular data warehousing project.
Rationale and design of a randomized trial on the effectiveness of aerobic interval training in patients with coronary artery disease: the SAINTEX-CAD study.

BACKGROUND
Exercise-based cardiac rehabilitation is considered an important adjunct treatment and secondary prevention measure in patients with coronary artery disease (CAD). However, the issues of training modality and exercise intensity for CAD patients remain controversial.


OBJECTIVE
Main aim of the present study is to test the hypothesis that aerobic interval training (AIT) yields a larger gain in peak aerobic capacity (peakVO2) compared to a similar training programme of moderate continuous training (MCT) in CAD patients.


STUDY DESIGN
In this multicentre study stable CAD patients with left ventricular ejection fraction>40% will be randomized after recent myocardial infarction or revascularization (PCI or CABG) to a supervised 12-week programme of three weekly sessions of either AIT (85-90% of peak oxygen uptake [peakVO2], 90-95% of peak heart rate) or MCT (60-70% of peakVO2, 65-75% of peak heart rate). The primary endpoint of the study is the change of peakVO2 after 12 weeks training. Secondary endpoints include safety, changes in peripheral endothelial vascular function, the evolution of traditional cardiovascular risk factors, quality of life and the number and function of circulating endothelial progenitor cells as well as endothelial microparticles. Possible differences in terms of long-term adherence to prescribed exercise regimens will be assessed by regular physical activity questionnaires, accelerometry and reassessment of peakVO2 12 months after randomization. A total number of 200 patients will be randomized in a 1:1 manner (significance level of 0.05 and statistical power of 0.90). Enrolment started December 2010; last enrolment is expected for February 2013.
Searching for processes and threads in Microsoft Windows memory dumps

Current tools to analyze memory dumps of systems running Microsoft Windows usually build on the concept of enumerating lists maintained by the kernel to keep track of processes, threads and other objects. Therefore they will frequently fail to detect objects that are already terminated or which have been hidden by Direct Kernel Object Manipulation
Effectiveness of adjunctive antidepressant treatment for bipolar depression.

BACKGROUND
Episodes of depression are the most frequent cause of disability among patients with bipolar disorder. The effectiveness and safety of standard antidepressant agents for depressive episodes associated with bipolar disorder (bipolar depression) have not been well studied. Our study was designed to determine whether adjunctive antidepressant therapy reduces symptoms of bipolar depression without increasing the risk of mania.


METHODS
In this double-blind, placebo-controlled study, we randomly assigned subjects with bipolar depression to receive up to 26 weeks of treatment with a mood stabilizer plus adjunctive antidepressant therapy or a mood stabilizer plus a matching placebo, under conditions generalizable to routine clinical care. A standardized clinical monitoring form adapted from the mood-disorder modules of the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, fourth edition, was used at all follow-up visits. The primary outcome was the percentage of subjects in each treatment group meeting the criterion for a durable recovery (8 consecutive weeks of euthymia). Secondary effectiveness outcomes and rates of treatment-emergent affective switch (a switch to mania or hypomania early in the course of treatment) were also examined.


RESULTS
Forty-two of the 179 subjects (23.5%) receiving a mood stabilizer plus adjunctive antidepressant therapy had a durable recovery, as did 51 of the 187 subjects (27.3%) receiving a mood stabilizer plus a matching placebo (P=0.40). Modest nonsignificant trends favoring the group receiving a mood stabilizer plus placebo were observed across the secondary outcomes. Rates of treatment-emergent affective switch were similar in the two groups.


CONCLUSIONS
The use of adjunctive, standard antidepressant medication, as compared with the use of mood stabilizers, was not associated with increased efficacy or with increased risk of treatment-emergent affective switch. Longer-term outcome studies are needed to fully assess the benefits and risks of antidepressant therapy for bipolar disorder. (ClinicalTrials.gov number, NCT00012558 [ClinicalTrials.gov].).
Solar powered water quality monitoring system using wireless sensor network

The idea of `Underwater Wireless Sensor Network' (UWSN) is the basic building block of a water quality monitoring using wireless sensor network (WSN) technology powered by solar panel. To monitor water quality over different sites as a real-time application, an excellent system architecture constituted by distributed sensor nodes and a base station is suggested. The nodes and base station are connected using WSN technology like Zigbee. Design and implementation of a prototype model using one node powered by solar cell and WSN technology is the challenging work. Data collected by various sensors at the node side such as pH, turbidity and oxygen level is sent via WSN to the base station. Data collected from the remote site can be displayed in visual format as well as it can be analyzed using different simulation tools at base station. This novel system has advantages such as no carbon emission, low power consumption, more flexible to deploy at remote site and so on.
Appropriate technologies to replenish soil fertility in southern Africa

In southern Africa, soil nutrient reserves are being depleted because of continued nutrient mining without adequate replenishment. The consequent downward spiral of soil fertility has led to a corresponding decline in crop yields, food insecurity, food aid and environmental degradation. The central issue for improving agricultural productivity in southern Africa is how to build up and maintain soil fertility despite the low incomes of smallholder farmers and the increasing land and labour constraints they face. Under this review five main options namely: inorganic fertilizers, grain legumes, animal manures, integrated nutrient management and agroforestry options appropriate to smallholder farmers are presented. Issues addressed in the use of inorganic fertilizers are reduction in fertilizer costs, timely availability and use efficiency. Legumes can be used to diversify farm system productivity but this requires P and lime application to support better legume growth and biological nitrogen fixation (BNF) as well as development of markets for various legume products. Manure availability and quality are central issues in increasing smallholder farm productivity and increasing its efficiency through proper handling and application methods. Integrated nutrient management of soil fertility by combined application of both inputs will increase use efficiency of inputs and reduce costs and increase profitability; but the challenge is often how to raise adequate amounts of either inorganic or organic inputs. Issues such as quality of inputs, nutrient balancing, labour to collect and transport organic inputs and their management need to be optimized. These are the challenges of adoption as are the scaling up of these options to millions of small-scale farmers.
Electrophysiological, hemodynamic, and metabolic response to open procedure or endovascular repair of infrarenal aortic aneurysms.

BACKGROUND
The occurrence of cardiovascular diseases in the group of patients undergoing vascular surgery because of abdominal aorta aneurysm is very high. Endovascular procedures are regarded as hemodynamically safer for the patients. The aim of this study was to compare the changes in electrophysiological, hemodynamic, and metabolic parameters depending on the type of operation, using invasive hemodynamic monitoring and Holter electrocardiography recording.


METHODS
A prospective, observational, nonrandomized study was conducted to compare dynamic changes of electrophysiological parameters (dominant rhythm, arrhythmia, corrected QT interval (QTc), invasive blood pressure, electrolytes, and acid-base balance in defined points during perioperative time in 2 groups: vascular prosthesis implantation group (91 patients) and stent-graft implantation group (83 patients).


RESULTS
The study group comprised 174 consecutive adult Caucasian patients (mean age 64.4 ± 8.9 years in stent-graft group and 70.0 ± 7.5 years in vascular prosthesis implantation group). Although patients in the stent-graft implantation group were younger, they were diagnosed with lower limbs vascular atherosclerosis, type 2 diabetes mellitus, and a lower left ventricle ejection fraction more often than patients in the open procedure group. During the open procedure, higher blood pressure amplitudes (P = 0.00009), higher decrease in pH (P = 0.049), increase in the arterial lactate level (P = 0.00002), prolonged QTc values (P = 0.001), more frequent ventricular extrasystoles (P = 0.005), and cardiovascular deaths were observed, when compared with those observed during the endovascular aneurysm repair.


CONCLUSIONS
When compared with the chosen techniques, the one for infrarenal abdominal aneurysm was found to be associated with significant differences in electrophysiological, hemodynamic, and metabolic parameters.
The role of genital nerve afferents in the physiology of the sexual response and pelvic floor function.

INTRODUCTION
Our understanding of genital and pelvic floor physiology is rapidly expanding. Penile erection is a neurovascular event controlled by spinal autonomic centers, the activity of which is dependent on input from supraspinal centers and the genitalia. Genital afferent stimulation excites spinal autonomic nuclei and supraspinal sexual centers of both genders.


AIM
To present a detailed understanding of the functional importance of genital afferent neuroanatomy and neurophysiology.


METHODS
  English-written articles of diverse disciplines from 1980 to 2010 that contained information on genital anatomy, pudendal/dorsal/perineal/cavernous nerves, vibratory stimulation, reflexogenic erection, peripheral/central nervous system-mediated erectile and micturition pathways, and sexual arousal in animals and humans were reviewed.


MAIN OUTCOME MEASURES
Analysis of supporting evidence for the role of genital afferents in the physiology of erectile response and pelvic floor function.


RESULTS
Basic science and clinical studies support the concept that pudendal nerve circuitry serves an essential purpose for sexual behavior, erectile function, penile rigidity, ejaculation, and micturition. Males and females share a comparable pattern of genital afferent neuroanatomy and neurophysiology, and sexual and micturition reflexes are similar in both genders. Pudendal nerve branches communicate with the cavernous nerves and are nitric oxide synthase positive. Genital afferents activate multiple spinal reflexes that modulate erection and micturition. Genital sensory information is transmitted to supraspinal centers important for sexual function.


CONCLUSIONS
  There is expanding support for the critical role of genital afferent neurophysiology in the mechanisms of erectile function and micturition. Genital afferent stimulation is a safe and natural modality that can be harnessed to amplify autonomic and somatic activity within the penis, female genitalia, spinal cord, and higher centers via established neurological principles. Such physiological adaptive processes may be beneficial in improving sexual response, erectile function, and micturition in many disease states, including in men after radical pelvic surgery. Well-designed and -executed studies in each specific population are needed to authenticate such prospects.
Random Forest variable importance with missing data

Random Forests are commonly applied for data prediction and interpretation. The latter purpose is supported by variable importance measures that rate the relevance of predictors. Yet existing measures can not be computed when data contains missing values. Possible solutions are given by imputation methods, complete case analysis and a newly suggested importance measure. However, it is unknown to what extend these approaches are able to provide a reliable estimate of a variables relevance. An extensive simulation study was performed to investigate this property for a variety of missing data generating processes. Findings and recommendations: Complete case analysis should not be applied as it inappropriately penalized variables that were completely observed. The new importance measure is much more capable to reflect decreased information exclusively for variables with missing values and should therefore be used to evaluate actual data situations. By contrast, multiple imputation allows for an estimation of importances one would potentially observe in complete data situations.
Introduction to Response to Intervention : What , why , and how valid is it ?

On December 3, 2004, President Bush signed into law the Individuals with Disabilities Education Improvement Act (IDEA, 2004). The revised law is different from the previous version in at least one important respect. Whereas practitioners were previously encouraged to use IQ–achievement discrepancy to identify children with learning disabilities (LD), they now may use “Response to Intervention,” or RTI, a new, alternative method. It is also a means of providing early intervention to all children at risk for school failure. IDEA 2004 permits districts to use as much as 15% of their special education monies to fund early intervention activities. All this has implications for the number and type of children identified, the kinds of educational services provided, and who delivers them. RTI may be especially important to Reading Research Quarterly readers because roughly 80% of those with an LD label have been described as reading disabled (Lyon, 1995). With RTI, there may be a larger role for reading specialists, which in turn might affect preand inservice professional development activities conducted by universities and school districts. Yet much still needs to be understood to ensure that RTI implementation will promote effective early intervention and represents a valid means of LD identification. In this article, we explain important features of RTI, why it has been promoted as a substitute for IQ–achievement discrepancy, and what remains to be understood before it may be seen as a valid means of LD identification. What is RTI?
On the Evolution of Magnetic Fields in the Early Universe

We address the question of the existence of magnetic domains in a recent scenario for the creation of primordial magnetic fields. We write down the magnetohydrodynamic equation in an expanding universe in the infinite conductivity limit and discuss its solution. No domains are found.
Use of total cerebral blood flow as an imaging biomarker of known cardiovascular risks.

BACKGROUND AND PURPOSE
This study examined whether overall cerebral blood flow was associated with known vascular risk factors, including cardiometabolic risk factors that comprise the metabolic syndrome, carotid artery intima-media thickness, and the Framingham risk score.


METHODS
Three separate samples were available for analysis. Two comparable samples were combined to form a primary sample of middle-aged participants (n=576; 30-55 years of age) that completed both a risk factor assessment and a resting brain scan. Samples were recruited via mailings and advertisements within an urban area. Quantitative measures of cerebral blood flow were derived from arterial spin-labeled MRI in this sample and in a validation/generalization sample (n=76; 30-55 years).


RESULTS
Cerebral blood flow was inversely associated with cardiometabolic risk indices, that is, associated with lower waist circumference, systolic blood pressure, glucose, and triglyceride and high-density lipoprotein. Moreover, cerebral blood flow was also related to Framingham risk and carotid intima-media thickness. In the validation sample, which used a slightly different brain imaging technique, significant relationships were replicated for cardiometabolic risk, but not for Framingham risk.


CONCLUSIONS
Reduced cerebral blood flow seems to be a correlate of vascular disease risk factors associated with cardiometabolic dysregulation. Cerebral blood flow may provide a valid imaging biomarker for cardiovascular risk.
Objective and subjective memory ratings in cannabis-dependent adolescents.

BACKGROUND AND OBJECTIVES
Cannabis is the most widely used illicit substance worldwide, with an estimated 160 million users. Among adolescents, rates of cannabis use are increasing, while the perception of detrimental effects of cannabis use is declining. Difficulty with memory is one of the most frequently noted cognitive deficits associated with cannabis use, but little data exist exploring how well users can identify their own memory deficits, if present.


METHODS
The current secondary analysis sought to characterize objective verbal and visual memory performance via a neurocognitive battery in cannabis-dependent adolescents enrolled in a pharmacotherapeutic cannabis cessation clinical trial (N = 112) and compare this to a single self-reported item assessing difficulties with memory loss. Exploratory analyses also assessed dose-dependent effects of cannabis on memory performance.


RESULTS
A small portion of the study sample (10%) endorsed a "serious problem" with memory loss. Those participants reporting "no problem" or "serious problem" scored similarly on visual and verbal memory tasks on the neurocognitive battery. Exploratory analyses suggested a potential relationship between days of cannabis use, amount of cannabis used, and gender with memory performance.


CONCLUSIONS AND SCIENTIFIC SIGNIFICANCE
This preliminary and exploratory analysis suggests that a sub-set of cannabis users may not accurately perceive difficulties with memory. Further work should test this hypothesis with the use of a control group, comprehensive self-reports of memory problems, and adult populations that may have more years of cannabis use and more severe cognitive deficits.
Associations of HLA-DP Variants with Hepatitis B Virus Infection in Southern and Northern Han Chinese Populations: A Multicenter Case-Control Study

BACKGROUND
Human leukocyte antigen DP (HLA-DP) locus has been reported to be associated with hepatitis B virus (HBV) infection in populations of Japan and Thailand. We aimed to examine whether the association can be replicated in Han Chinese populations.


METHODOLOGY/PRINCIPAL FINDINGS
Two HLA-DP variants rs2395309 and rs9277535 (the most strongly associated SNPs from each HLA-DP locus) were genotyped in three independent Han cohorts consisting of 2 805 cases and 1 796 controls. By using logistic regression analysis, these two SNPs in the HLA-DPA1 and HLA-DPB1 genes were significantly associated with HBV infection in Han Chinese populations (P = 0.021∼3.36×10(-8) at rs2395309; P = 8.37×10(-3)∼2.68×10(-10) at rs9277535). In addition, the genotype distributions of both sites (rs2395309 and rs9277535) were clearly different between southern and northern Chinese population (P = 8.95×10(-5) at rs2395309; P = 1.64×10(-9) at rs9277535). By using asymptomatic HBV carrier as control group, our study showed that there were no associations of two HLA-DP variants with HBV progression (P = 0.305∼0.822 and 0.163∼0.881 in southern Chinese population, respectively; P = 0.097∼0.697 and 0.198∼0.615 in northern Chinese population, respectively).


CONCLUSIONS
Our results confirmed that two SNPs (rs2395309 and rs9277535) in the HLA-DP loci were strongly associated with HBV infection in southern and northern Han Chinese populations, but not with HBV progression.
Collaborative Filtering for People to People Recommendation in Social Networks

Predicting people other people may like has recently become an important task in many online social networks. Traditional collaborative filtering approaches are popular in recommender systems to effectively predict user preferences for items. However, in online social networks people have a dual role as both “users” and “items”, e.g., both initiating and receiving contacts. Here the assumption of active users and passive items in traditional collaborative filtering is inapplicable. In this paper we propose a model that fully captures the bilateral role of user interactions within a social network and formulate collaborative filtering methods to enable people to people recommendation. In this model users can be similar to other users in two ways – either having similar “taste” for the users they contact, or having similar “attractiveness” for the users who contact them. We develop SocialCollab, a novel neighbourbased collaborative filtering algorithm to predict, for a given user, other users they may like to contact, based on user similarity in terms of both attractiveness and taste. In social networks this goes beyond traditional, merely taste-based, collaborative filtering for item selection. Evaluation of the proposed recommender system on datasets from a commercial online social network show improvements over traditional collaborative filtering.