LLukas22/scidocs huggingface dataset:
Gastroprotective effect of crocin in ethanol-induced gastric injury in rats.

The present study investigated the gastroprotective effect of crocin in ethanol-induced gastric injury in rats. Rats were allocated into a normal group, an ulcer group, a crocin-treated group, an ulcer group pretreated with crocin, and an ulcer group pretreated with omeprazole as a reference anti-ulcer drug. Rats were sacrificed 3h after ethanol administration. Prophylactic administration of crocin (50mg/kg/day, i.p.) for 3 consecutive days before the administration of 70% ethanol (10 ml/kg, orally) resulted in significant gastroprotection compared to ethanol-ulcerated rats as manifested by significant reduction in the gastric ulcer index. Crocin pretreatment increased ethanol-lowered levels of gastric juice mucin and mucosal prostaglandin E2 (PGE2) and interleukin-6 (IL-6). Moreover, crocin significantly decreased ethanol-elevated tumor necrosis factor-alpha (TNF-α) level, myeloperoxidase activity and heat shock protein 70 mRNA and protein levels. It also restored ethanol-altered mucosal levels of glutathione, malondialdehyde and superoxide dismutase activity. Furthermore, crocin-pretreatment alleviated ethanol-induced mucosal apoptosis as revealed by significant down-regulation of cytochrome c and caspase-3 mRNA expression, significant decrease in caspase-3 activity and mitigated DNA fragmentation as indicated by significant decrements in comet parameters. The protective efficacy of crocin was further supported by histological assessment. No significant difference was observed between crocin and omeprazole (20mg/kg orally 1h before ethanol administration) regarding their mucin-secretagogue and antioxidant effects, as well as their effects on TNF-α, IL-6 and cytochrome c. On the other hand, omeprazole was superior in enhancing PGE2 level and in alleviating neutrophil infiltration, caspase-3 activation and DNA fragmentation. Conclusively, crocin protects rat gastric mucosa against ethanol-induced injury via anti-inflammatory, anti-oxidative, anti-apoptotic and mucin-secretagogue mechanisms that are probably mediated by enhanced PGE2 release.
New Dimensions in Patient–Physician Interaction: Values, Autonomy, and Medical Information in the Patient-Centered Clinical Encounter

Patient-physician interactions are increasingly influenced by the extraordinary diversification of populations and rapid expansion of medical knowledge that characterize our modern era. By contrast, the patient-physician interaction models currently used to teach medical trainees have little capacity to address these twin challenges. We developed a new model of patient-physician interaction to explicitly address these problems. Historically, models of patient-physician interaction viewed patient autonomy and the manifestation of clearly defined health care-related values as tightly linked, and it was assumed that patients' medical knowledge was low. Unfortunately, this does not adequately represent patients such as 1) the highly educated non-medical specialist who possesses little familiarity with health-related values but is highly autonomous, and 2) the patient from a non-Western background who may have well-established health care-related values but a low sense of personal independence. In addition, it is evident to us that the assumption that all patients possess little medical knowledge can create alienation between patient and physician, e.g. the well-informed patient with a rare disease. We propose a paradigm that models autonomy, health care-related values formation, and medical knowledge as varying from patient to patient. Four examples of patient types are described within the context of the model based on clinical experience. We believe that adopting this model will have implications for optimizing patient-physician interactions and teaching about patient-centered care. Further research is needed to identify relevant patient types within this framework and to assess the impact on health care outcomes.
A general analytical algorithm for collaborative robot (cobot) with 6 degree of freedom (DOF)

The Forward and inverse kinematics of the robot is the connection of mechanical system motion and control system. There is no closed form solution for inverse kinematics of 6 DOF robots currently. The method of numerical iterative algorithm is used usually, but which is hard to ensure the requirement of real-time and accuracy. Considering the application and characteristic of cobot, we designed the mechanical structure and distributed the 6 DOF of it. This paper uses the analytical method to get the consequence of the forward and inverse kinematics of the robot. It ensures the most important characteristics of real-time and accuracy. It can also get the singularity of the robot easily. At last, we verified the method by simulation in MATLAB.
Apache Spark: a unified engine for big data processing

This open source computing framework unifies streaming, batch, and interactive big data workloads to unlock new applications.
The Adoption of Mobile Payment Services for “ Fintech ”

This paper examined the acceptance of payment-type Fintech services of users by utilizing the Elaboration Likelihood Model by Petty and Cacioppo [1] and by applying variables associated with the Technology Acceptance Model. In addition, it analyzed the causal relationship between concern for information privacy and self-efficacy by adopting them as moderating variables. Results suggested that usefulness, ease of use and credibility had an effect on intention to use, and self-efficacy was found to have an moderating effect on independent and dependent variables. Further, concern for information privacy was found to be a factor obstructing the path to intention to use. The implications of this study are that in the promotion of payment-type Fintech services, convenience and usefulness are the most critical and influential variables in terms of usage, while government deregulation and stronger security are called for from an institutional aspect.
Intervention to Prevent Child Custody Loss in Mothers with Schizophrenia

Depending on jurisdiction, time period studied, and specifics of the population, approximately 50 percent of mothers who suffer from schizophrenia lose custody of their children. The aim of this paper is to recommend interventions aimed at preventing unnecessary custody loss. This paper reviews the social work, nursing, psychology, psychiatry, and law literature on mental illness and custody loss, 2000-2011. Recommendations to mothers are to (a) ensure family health (b) prevent psychotic relapse, (c) prepare in advance for crisis, (d) document daily parenting activities, (e) take advantage of available parenting resources, and f) become knowledgeable about legal issues that pertain to mental health and custody. From a policy perspective, child protection and adult mental health agencies need to dissolve administrative barriers and collaborate. Access to appropriate services will help mothers with schizophrenia to care appropriately for their children and allow these children to grow and develop within their family and community.
Consumer attitudes toward and intentions to accept mobile advertising

Article history: Received March 25, 2015 Received in revised format June 1 2015 Accepted June 27 2015 Available online July 1 2015 The objective of this study was to examine the drivers of consumers’ attitudes towards mobile advertisement. It also sought the relationship between consumers’ attitudes towards mobile advertisement and their willingness to accept mobile advertising. Confirmatory factor analysis was used to assess the measurement model while structural equation was conducted to assess the goodness-fit of the overall model. The findings indicate that entertainment, credibility and personalization had positive effects on consumers’ attitudes toward mobile advertising. Furthermore, the results show that, consumers’ attitude determines their willingness to accept mobile advertising.
Ghost hunters: ambient light and hand gesture utilization in mobile augmented reality games

This paper presents the current status of work-in-progress in developing Ghost Hunters that is targeted to explore the possibilities of incorporating gesture control and ambient lighting in a mobile augmented reality game played with smart glasses. We present the design and implementation of the current prototype, together with a small feasibility evaluation of battery consumption and gesture control.
The Crowd in Requirements Engineering: The Landscape and Challenges

Crowd-based requirements engineering (CrowdRE) could significantly change RE. Performing RE activities such as elicitation with the crowd of stakeholders turns RE into a participatory effort, leads to more accurate requirements, and ultimately boosts software quality. Although any stakeholder in the crowd can contribute, CrowdRE emphasizes one stakeholder group whose role is often trivialized: users. CrowdRE empowers the management of requirements, such as their prioritization and segmentation, in a dynamic, evolved style through collecting and harnessing a continuous flow of user feedback and monitoring data on the usage context. To analyze the large amount of data obtained from the crowd, automated approaches are key. This article presents current research topics in CrowdRE; discusses the benefits, challenges, and lessons learned from projects and experiments; and assesses how to apply the methods and tools in industrial contexts. This article is part of a special issue on Crowdsourcing for Software Engineering.
Robust and Flexible Power-Proportional Storage (CMU-PDL-10-106)

Power-proportional cluster-based storage is an important component of an overall cloud computing infrastructure. With it, substantial subsets of nodes in the storage cluster can be turned off to save power during periods of low utilization. Rabbit is a distributed file system that arranges its data-layout to provide ideal power-proportionality down to very low minimum number of powered-up nodes (enough to store a primary replica of available datasets). Rabbit addresses the node failure rates of large-scale clusters with data layouts that minimize the number of nodes that must be powered-up if a primary fails. Rabbit also allows different datasets to use different subsets of nodes as a building block for interference avoidance when the infrastructure is shared by multiple tenants. Experiments with a Rabbit prototype demonstrate its power-proportionality, and simulation experiments demonstrate its properties at scale. Acknowledgements: We thank the members and companies of the PDL Consortium (including APC, Data Domain, EMC, Facebook, Google, Hewlett-Packard Labs, Hitachi, IBM, Intel, LSI, Microsoft, NEC Laboratories, NetApp, Oracle, Seagate, Sun, Symantec, VMWare, and Yahoo! Labs) for their interest, insights, feedback, and support. This research was sponsored in part by NSF grants #CNS-0326453, by Intel Labs Pittsburgh, by DoE award DE-FC02-06ER25767, and by CyLab under ARO grant DAAD19-02-1-0389. Intel enabled the experiments with funding and generous hardware donations. We would also like to thank Intel corporation for providing funding and equipment, and IBM research for their generous support.
The influence of total nodes examined, number of positive nodes, and lymph node ratio on survival after surgical resection and adjuvant chemoradiation for pancreatic cancer: a secondary analysis of RTOG 9704.

PURPOSE
Lymph node status is an important predictor of survival in pancreatic cancer. We performed a secondary analysis of Radiation Therapy Oncology Group (RTOG) 9704, an adjuvant chemotherapy and chemoradiation trial, to determine the influence of lymph node factors--number of positive nodes (NPN), total nodes examined (TNE), and lymph node ratio (LNR ratio of NPN to TNE)--on OS and disease-free survival (DFS).


PATIENT AND METHODS
Eligible patients from RTOG 9704 form the basis of this secondary analysis of lymph node parameters. Actuarial estimates for OS and DFS were calculated using Kaplan-Meier methods. Cox proportional hazards models were performed to evaluate associations of NPN, TNE, and LNR with OS and DFS. Multivariate Cox proportional hazards models were also performed.


RESULTS
There were 538 patients enrolled in the RTOG 9704 trial. Of these, 445 patients were eligible with lymph nodes removed. Overall median NPN was 1 (min-max, 0-18). Increased NPN was associated with worse OS (HR=1.06, p=0.001) and DFS (HR=1.05, p=0.01). In multivariate analyses, both NPN and TNE were associated with OS and DFS. TNE>12, and >15 were associated with increased OS for all patients, but not for node-negative patients (n=142). Increased LNR was associated with worse OS (HR=1.01, p<0.0001) and DFS (HR=1.006, p=0.002).


CONCLUSION
In patients who undergo surgical resection followed by adjuvant chemoradiation, TNE, NPN, and LNR are associated with OS and DFS. This secondary analysis of a prospective, cooperative group trial supports the influence of these lymph node parameters on outcomes after surgery and adjuvant therapy using contemporary techniques.
Implementation of Reverse Vending Machine Based on FPGA

Department of Electronics and Communication DAV Institute of Engineering and Technology, Jalandhar, Punjab, India ___________________________________________________________________________________ ABSTRACT: In these modern days, Reverse Vending Machine is very popular to Korea, Japan, England, Britain, Greece and China. Reverse Vending Machine saves time, employee work and also save human’s energy. This paper describes about the Reverse Vending Machine which works after inserting the empty beverage container into it. The project of Reverse Vending Machine (RVM) is useless without the cooperation of consumer. This is very attractive and motivated prize for the consumer through the RVM i.e. Refund. This paper addresses the implementation of Reverse Vending Machine based on FPGA. RVM is based on that process in which a machine accepts empty remaining containers and gives output according to the number of container. In this Paper, RVM supports empty containers, coins, snacks, chocolate, cold-drink etc. The algorithm for it is implemented in VHDL and simulated using Xilinx FPGA Spartan 3 development board.
Efficacy and safety of remifemin compared to tibolone for controlling of perimenopausal symptoms ]

To investigate the efficacy and safety of remifemin (isopropanolic extract of cimicifuga racemosa) treating perimenopausal symptoms in comparison of tibolone. One hundred and eighty postmenopausal women at range of 40 60 years old were enrolled in a multicenter, randomized and double blind study. They were divided into remifemin and tibolone group at ratio 1:1. The therapeutic strategy was remifemin 20 mg bid po for 12 weeks in remifemin group and tibolone 2.5 mg qd po for 12 weeks in tibolone group. To evaluate therapeutic effect, total score of Kupperman menopause index (KMI) was used as the major observed index and single item score of KMI were secondary observed index. Safety warning was determined by laboratory tests and adverse events at timepoint of before, at 4 and 12 weeks treatment. (1) Total score of KMI: it were 24 +/5 in remifemin group and 25 +/6 in tibolone group before treatment. At timepoint of 4 weeks treatment, it were 11 +/6 in remifemin group and 11 +/7 in tibolone group. At timepoint of 12 weeks treatment, it were 7 +/6 in remifemin group and 6 +/5 in tibolone group. Total KMI score between two groups did not show statistical difference at various timepoint (P > 0.05). (2) Single item score of KMI: when compared before, at 4 and 12 weeks treatment, did show remarkable difference (P < 0.05) either in remifemin or in tibolone group. However, those single items of KMI score did not show statistical difference between 4 and 12 weeks timepoint in each treatment group (P > 0.05). (3) Adverse effect: the incidence of adverse effect in remifemin group was significantly lower than that of tibolone group. None case with vaginal bleeding was observed in remifemin group, however, 17 cases with vaginal bleeding occurred in tibolone group (19%, 17/90). The incidence of breast swelling were 16% (14/90) in remifemin group and 36% (32/90) in tibolone group; before treatment, the thickness of endometrium were (2.6 +/1.1) mm in remifemin group and (2.8 +/1.1) mm in tibolone group; at timepoint of 12 weeks treatment, the thickness of endometrium were (2.9 +/1.4) mm in remifemin group and (3.4 +/2.0) mm in tibolone group. In comparison of thickness of endometrium before and at 12 weeks treatment, no remarkable changes was observed in remifemin group, however, endometrium displayed significantly thicker in tibolone group. Our study suggested that remifemin was one effective and safe agent to manage women with climacteric symptom. It has similar therapeutic effect and lower incidence of adverse effect when compared with tibolone. Display Settings: Abstract PubMed Search 21/05/12 [Efficacy and safety of remifemin... [Zhonghua Fu Chan Ke Za Zhi. 2009] PubMed NCBI 2/2 www.ncbi.nlm.nih.gov/pubmed/20003788 PMID: 20003788 [PubMed indexed for MEDLINE] Publication Types, MeSH Terms, Substances LinkOut more resources
Effects of increasing fuzziness on analytic hierarchy process for spatial multicriteria decision analysis

Multicriteria decision analysis (MCDA) involves techniques which relatively recently have received great increase in interest for their capabilities of solving spatial decision problems. One of the most frequently used techniques of MCDA is Analytic Hierarchy Process (AHP). In the AHP, decision-makers make pairwise comparisons between different criteria to obtain values of their relative importance. The AHP initially only dealt with crisp numbers or exact values in the pairwise comparisons, but later it has been modified and adapted to also consider fuzzy values. It is necessary to empirically validate the ability of the fuzzified AHP for solving spatial problems. Further, the effects of different levels of fuzzification on the method have to be studied. In the context of a hypothetical GIS-based decision-making problem of locating a dam in Costa Rica using real-world data, this paper illustrates and compares the effects of increasing levels of uncertainty exemplified through different levels of fuzzification of the AHP. Practical comparison of the methods in this work, in accordance with the theoretical research, revealed that by increasing the level of uncertainty or fuzziness in the fuzzy AHP, differences between results of the conventional and fuzzy AHPs become more significant. These differences in the results of the methods may affect the final decisions in decision-making processes. This study concludes that the AHP is sensitive to the level of fuzzification and decision-makers should be aware of this sensitivity while using the fuzzy AHP. Furthermore, the methodology described may serve as a guideline on how to perform a sensitivity analysis in spatial MCDA. Depending on the character of criteria weights, i.e. the degree of fuzzification, and its impact on the results of a selected decision
The Comparison of Cervical Repositioning Errors According to Smartphone
Addiction Grades

[Purpose] The purpose of this study was to compare cervical repositioning errors according to smartphone addiction grades of adults in their 20s. [Subjects and Methods] A survey of smartphone addiction was conducted of 200 adults. Based on the survey results, 30 subjects were chosen to participate in this study, and they were divided into three groups of 10; a Normal Group, a Moderate Addiction Group, and a Severe Addiction Group. After attaching a C-ROM, we measured the cervical repositioning errors of flexion, extension, right lateral flexion and left lateral flexion. [Results] Significant differences in the cervical repositioning errors of flexion, extension, and right and left lateral flexion were found among the Normal Group, Moderate Addiction Group, and Severe Addiction Group. In particular, the Severe Addiction Group showed the largest errors. [Conclusion] The result indicates that as smartphone addiction becomes more severe, a person is more likely to show impaired proprioception, as well as impaired ability to recognize the right posture. Thus, musculoskeletal problems due to smartphone addiction should be resolved through social cognition and intervention, and physical therapeutic education and intervention to educate people about correct postures.
Can a Back Pain E-mail Discussion Group improve health status and lower health care costs?: A randomized study.

BACKGROUND
Given the high health care utilization, limited evidence for the effectiveness of back pain interventions, and the proliferation of e-mail health discussion groups, this study seeks to determine if the Internet can be used to improve health status and health care utilization for people with chronic back pain.


METHODS
Randomized controlled trial. Participants included 580 people from 49 states with chronic back pain having at least 1 outpatient visit in the past year, no "red-flag" symptoms, and access to e-mail. Major exclusion criteria included continuous back pain for more than 90 days causing major activity intolerance and/or receiving disability payments.


INTERVENTION
Closed, moderated, e-mail discussion group. Participants also received a book and videotape about back pain. Controls received a subscription to a non-health-related magazine of their choice.


MAIN OUTCOME MEASURES
Pain, disability, role function, health distress, and health care utilization.


RESULTS
At 1-year treatment, subjects compared with controls demonstrated improvements in pain (P =.045), disability (P =.02), role function (P =.007), and health distress (P =.001). Physician visits for the past 6 months declined by 1.5 visits for the treatment group and by 0.65 visits for the control group (P =.07). Mean hospital days declined nearly 0.20 days for the treated group vs and increased 0.04 days for the control group (P =.24).


CONCLUSIONS
An e-mail discussion group can positively affect health status and possibly health care utilization. It may have a place in the treatment of chronic recurrent back pain.
CAAD: Computer Architecture for Autonomous Driving

We describe the computing tasks involved in autonomous driving, examine existing autonomous driving computing platform implementations. To enable autonomous driving, the computing stack needs to simultaneously provide high performance, low power consumption, and low thermal dissipation, at low cost. We discuss possible approaches to design computing platforms that will meet these needs.