LLukas22/scidocs huggingface dataset:
Influence of atorvastatin on blood pressure control in treated hypertensive, normolipemic patients - An open, pilot study.

AIMS
The aim of the study was to determine whether a high dose of atorvastatin lowers blood pressure (BP) in normolipemic patients with well controlled primary arterial hypertension and if this effect is associated with alteration of biomarkers of endothelial function and oxidative stress. In this open-label study, normolipemic patients (n=56) were randomized in the proportion of 2:1 to receive atorvastatin 80 mg daily for 3 months (statin-treated, ST n=39), or to previous therapy (statin-free, SF). BP was measured using a 24-h ambulatory BP measurement device. Plasma levels of 6-keto-PGF(1alpha) (prostacyclin metabolite), serum nitric oxide (NO) and levels of autoantibodies immunoglobulin G against oxidatively modified low-density lipoprotein (ox-LDL) were measured.


MAJOR FINDINGS
The mean change in systolic BP and diastolic BP for ST was - 5.7 mmHg (95% CI -4.1 to -7.2 mmHg) and -3.9 mmHg (95% CI -2.7 to -5.0 mmHg), respectively. Hypotensive statin effect was independent of lipid lowering. No change of BP in SF patients was observed. In ST, prostacyclin metabolites and NO concentrations were not significantly increased and autoantibodies against ox-LDL concentrations did not change. In ST, the decrease in BP correlated with increase in NO and decrease in autoantibodies against ox-LDL.


PRINCIPAL CONCLUSION
High-dose atorvastatin resulted in reduction of BP independently of lipid-lowering effect, changes in endothelial function and oxidative stress, but it was related to the increase in NO and decrease in autoantibodies against ox-LDL. However, because of the open design of the study, these results should be carefully debated.
Effects of testosterone replacement therapy on skeletal muscle after spinal cord injury

Study design: Randomized control.Objective: To examine the effects of testosterone replacement therapy (TRT) on skeletal muscle 11 weeks after complete SCI.Setting: Athens, Georgia USA.Methods: Soleus (SOL), gastrocnemius (GA), tibialis anterior (TA), vastus lateralis (VL) and triceps brachii (TRI) muscles were taken from twelve young male Charles River rats 11 weeks after complete SCI (T-9 transection, n=8) or sham surgery (n=4). Rats received either TRT (two 5 cm capsules, n=4) or empty capsules (n=8) implanted at surgery. Muscle samples were sectioned and fibers analyzed qualitatively for myosin ATPase and quantitatively for succinate dehydrogenase (SDH), α-glycerol-phosphate dehydrogenase (GPDH) and actomyosin ATPase (qATPase) activities using standard techniques.Results: SCI decreased average fiber size (49±4%) in affected muscles and the percentage of slow fibers in SOL (93±3% to 17±2%). In addition, there was a decrease in SDH and an increase in GPDH and qATPase activities across the four hind-limb muscles of the SCI animals. Fiber size in the TRI was increased (31±2%) by SCI while enzyme activities were not altered. Average fiber size across the four hind limb muscles was decreased by only 30% in TRT SCI animals and their SOL contained 39±2% slow fibers. TRT also attenuated changes in enzyme activities. There was no effect of TRT on the TRI relative to SCI.Conclusions: TRT was effective in attenuating alterations in myofibrillar proteins during 11 weeks of SCI in affected skelatal muscles.Sponsorship: Supported by a grant from The National Institutes of Health (HD-33738) and HD-37645 to KV, and HD-39676 to GAD.
Overview of the CLEF 2009 Medical Image Annotation Track

This paper describe the last round of the medical image annotation task in ImageCLEF 2009. After four years, we defined the task as a survey of all the past experience. Seven groups participated to the challenge submitting 19 runs. They were asked to train their algorithms on 12,677 images, labeled according to four different settings representing the yearly annotation tasks, and to classify 1,733 images in the four annotation frameworks. The aim is to understand how each strategy answers to the increasing number of classes and to the unbalancing. A plain classification scheme using support vector machines and local descriptors outperformed the other methods.
A Review Paper on Face Recognition Techniques

The purpose of this paper is to review various face detection and recognition methods, Face recognition has been a fast growing, and Face Recognition is the problem related to the field of machine learning, challenging and interesting area in real time application. Computer vision and image analysis. Paper an effort is made to review an extensive range of present methodology of face recognition techniques
Biceps and Body Image: The Relationship Between Muscularity and Self-Esteem, Depression, and Eating Disorder Symptoms.

The present study examined body image and associated psychological traits in 154 college men. The comprehensive battery of measures included a novel computerized test of body image perception, the Somatomorphic Matrix, in which subjects could navigate through a range of body images, spanning a wide range of body fat and muscularity, to answer various questions posed by the computer. Subjects also completed paper-and-pencil instruments assessing depression, characteristics of eating disorders, self-esteem, and use of performance-enhancing substances. Findings suggest that contemporary American men display substantial body dissatisfaction and that this dissatisfaction is closely associated with depression, measures of eating pathology, use of performance-enhancing substances, and low self-esteem. Muscle belittlement, believing that one is less muscular than he is, presented as an important construct in the body dissatisfaction of men.
Cross-cultural adaptation of the Portuguese version of the Patient-Generated Subjective Global Assessment.

Introducción: la adaptación transcultural del PatientGenerated Subjective Global Assessment es importante ya que se puede utilizar con confianza en la lengua portuguesa. Objetivo: realizar una versión de adaptación transcultural al portugués del Patient-Generated Subjective Global Assessment y estimar su fiabilidad intra-observador. Material y métodos: se trata de un estudio de validación. La validez aparente fue clasificada por 17 profesionales sanitarios y 10 lingüistas portugueses. Se analizaron las equivalencias idiomáticas, semánticas, culturales y conceptuales. El cuestionario fue completado por 20 pacientes del Hospital Amaral Carvalho (Jaú, São Paulo, Brasil) con el fin de verificar el Índice de comprensión de cada ítem. Por lo tanto, 27 miembros del comité clasificaron cada ítem en “esencial”, “útil pero no esencial”, e “innecesario” con el fin de calcular el cociente de validez del contenido. Después, se aplicó esta versión del cuestionario dos veces a 62 pacientes del hospital antes mencionado. La fiabilidad intra-observador del estado estado nutricional analizada por el Patient-Generated Subjective Global Assessment se estimó mediante los estadísticos Kappa. Resultados: la versión portuguesa del Patient-Generated Subjective Global Assessment presentaba 10 expresiones incomprensibles. Los ítems “a year ago weight” y “dry mouth symptom” mostraron el menor cociente de validez del contenido. Se observó una fiabilidad intraobservador significativa (k = 0,78, p = 0,001). Conclusión: La adaptación transcultural de la versión portuguesa del Patient-Generated Subjective Global Assessment fue sencilla y comprensible para los pacientes brasileños. Por lo tanto, esta versión del Patient-Generated Subjective Global Assessment se consideró un método válido y fiable.
Performance after rotator cuff tear and operative treatment: a case-control study of major league baseball pitchers.

CONTEXT
Little is known about pitching performance or lack of it among Major League Baseball (MLB) pitchers who undergo operative treatment of rotator cuff tears.


OBJECTIVE
To assess pitching performance outcomes in MLB players who needed operative treatment of rotator cuff tears and to compare performance in these athletes with that in a control group of MLB players.


DESIGN
Case-control study.


SETTING
Publicly available player profiles, press releases, and team injury reports.


PATIENTS OR OTHER PARTICIPANTS
Thirty-three MLB pitchers with documented surgery to treat rotator cuff tears and 117 control pitchers who did not have documented rotator cuff tears were identified.


MAIN OUTCOME MEASURE(S)
Major League Baseball pitching attrition and performance variables.


RESULTS
Players who underwent rotator cuff surgery were no more likely not to play than control players. Performance variables of players who underwent surgery improved after surgery but never returned to baseline preoperative status. Players who needed rotator cuff surgery typically were more experienced and had better earned run averages than control players.


CONCLUSIONS
Pitchers who had symptomatic rotator cuff tears that necessitated operative treatment tended to decline gradually in performance leading up to their operations and to improve gradually over the next 3 seasons. In contrast to what we expected, they did not have a greater attrition rate than their control counterparts; however, their performances did not return to preoperative levels over the course of the study.
Statically detecting use after free on binary code

We present GUEB a static tool detecting Use after Free vulnerabilities on disassembled code. This tool has been evaluated on a real vulnerability in the ProFTPD application (CVE-2011-4130).
miR-345 in Metastatic Colorectal Cancer: A Non-Invasive Biomarker for Clinical Outcome in Non-KRAS Mutant Patients Treated with 3rd Line Cetuximab and Irinotecan

INTRODUCTION
MicroRNAs (miRNAs) have important regulatory functions in cellular processes and have shown promising potential as prognostic markers for disease outcome in patients with cancer. The aim of the present study was to find miRNA expression profiles in whole blood that were prognostic for overall survival (OS) in patients with metastatic colorectal cancer (mCRC) treated with cetuximab and irinotecan.


METHODS
From 138 patients with mCRC in 3rd line therapy with cetuximab and irinotecan in a prospective phase II study, 738 pretreatment miRNAs were isolated and profiled from whole blood using the TaqMan MicroRNA Array v2.0. Mutation status of KRAS, BRAF, and PI3KCA was known.


RESULTS
After Bonferroni adjustment, 6 miRNAs: (miR-345, miR-143, miR-34a*, miR-628-5p, miR-886-3p and miR-324-3p), were found associated with short OS. miR-345 was the strongest prognostic miRNA, significant in the full cohort and in the non-KRAS mutant population. miR-345, as a continuous variable in the full cohort, resulted in a hazard ratio (HR) of 2.38 per IQR (CI 95%: 1.8-3.1, P-value = 2.86e-07, Bonferroni adjusted, univariable analysis) and a HR = 1.75 per IQR (CI 95%: 1.24-2.48, P-Wald = 1.45e-03) in the multivariable analysis adjusted for gender, age, KRAS, PI3KCA and performance status. miR-345 was prognostic in progression-free survival (PFS) with a HR = 1.63 per IQR (CI 95%: 1.25-2.114, P-Wald = 2.92e-4) in the multivariable analysis. In addition, high miR-345 expression was associated with lack of response to treatment with cetuximab and irinotecan.


CONCLUSION
We identified miR-345 in whole blood as a potential biomarker for clinical outcome. MiR-345 was a single prognostic biomarker for both OS and PFS in all patients and also in the non-KRAS mutant population.
Robotic neurorehabilitation: a computational motor learning perspective

Conventional neurorehabilitation appears to have little impact on impairment over and above that of spontaneous biological recovery. Robotic neurorehabilitation has the potential for a greater impact on impairment due to easy deployment, its applicability across of a wide range of motor impairment, its high measurement reliability, and the capacity to deliver high dosage and high intensity training protocols. We first describe current knowledge of the natural history of arm recovery after stroke and of outcome prediction in individual patients. Rehabilitation strategies and outcome measures for impairment versus function are compared. The topics of dosage, intensity, and time of rehabilitation are then discussed. Robots are particularly suitable for both rigorous testing and application of motor learning principles to neurorehabilitation. Computational motor control and learning principles derived from studies in healthy subjects are introduced in the context of robotic neurorehabilitation. Particular attention is paid to the idea of context, task generalization and training schedule. The assumptions that underlie the choice of both movement trajectory programmed into the robot and the degree of active participation required by subjects are examined. We consider rehabilitation as a general learning problem, and examine it from the perspective of theoretical learning frameworks such as supervised and unsupervised learning. We discuss the limitations of current robotic neurorehabilitation paradigms and suggest new research directions from the perspective of computational motor learning.
Recurrent Neural Network Grammars

We introduce recurrent neural network grammars, probabilistic models of sentences with explicit phrase structure. We explain efficient inference procedures that allow application to both parsing and language modeling. Experiments show that they provide better parsing in English than any single previously published supervised generative model and better language modeling than state-of-the-art sequential RNNs in English and Chinese.
Alzheimer's disease: strategies for disease modification

Alzheimer's disease is the largest unmet medical need in neurology. Current drugs improve symptoms, but do not have profound disease-modifying effects. However, in recent years, several approaches aimed at inhibiting disease progression have advanced to clinical trials. Among these, strategies targeting the production and clearance of the amyloid-β peptide — a cardinal feature of Alzheimer's disease that is thought to be important in disease pathogenesis — are the most advanced. Approaches aimed at modulating the abnormal aggregation of tau filaments (another key feature of the disease), and those targeting metabolic dysfunction, are also being evaluated in the clinic. This article discusses recent progress with each of these strategies, with a focus on anti-amyloid strategies, highlighting the lessons learned and the challenges that remain.
Neuroticism Associated with Cocaine-Induced Psychosis in Cocaine-Dependent Patients: A Cross-Sectional Observational Study

BACKGROUND
Cocaine consumption can induce transient psychotic symptoms, which has been correlated with more severe addiction and aggressive behavior. However, little is known about the nature of the relationship between personality traits and psychotic symptoms in cocaine-dependent patients. This study examined the relationship between neuroticism and cocaine-induced psychosis.


METHODS
A total of 231 cocaine-dependent patients seeking treatment were recruited to the study. Personality was evaluated by the Zuckerman-Kuhlman Personality Questionnaire. Cocaine-induced psychosis questionnaire, SCID-I, and SCID-II were used to evaluate comorbidity and clinical characteristics. Data analysis was performed in three steps: descriptive, bivariate, and multivariate analyses.


RESULTS
Cocaine-induced psychosis was reported in 65.4% of the patients and some personality disorder in 46.8%. Two personality dimensions (Neuroticism-Anxiety and Aggression-Hostility) presented a significant effect on the risk of experiencing psychotic symptoms (t(229) = 2.69, p = 0.008; t(229) = 2.06, p = 0.004), and patients with psychotic symptoms showed higher scores in both variables. On the multivariate analysis, only Neuroticism remained as a significant personality factor independently associated with psychotic symptoms (Wald = 7.44, p<0.05, OR = 1.08, CI 95% 1.02-1.16) after controlling for age, gender and number of consumption substances.


CONCLUSIONS
An association between high neuroticism scores and presence of psychotic symptoms induced by cocaine has been found, independently of other consumption variables. Personality dimensions should be evaluated in cocaine-dependent patients in order to detect high scores of neuroticism and warn patients about the risk of developing cocaine-induced psychotic symptoms.
A phase II study of high-dose cetuximab plus irinotecan in colorectal cancer patients with KRAS wild-type tumors who progressed after standard dose of cetuximab plus irinotecan.

OBJECTIVES
We conducted a phase II clinical trial of high-dose cetuximab plus irinotecan in KRAS wild-type patients who progressed on standard-dose cetuximab plus irinotecan.


METHODS
Patients who progressed within 4 weeks from receiving a minimum of 6 weeks of standard-dose cetuximab plus irinotecan were included in this study. Cetuximab was administered at 500 mg/m(2)/week and irinotecan was administered at the same dose/schedule on which each individual patient had previously progressed. The study was closed early after having met its primary end point.


RESULTS
Twenty patients were treated. The regimen was found to be efficacious, with 9 patients achieving disease control lasting more than 12 weeks. The median progression-free survival and overall survival were 2.8 and 6.6 months, respectively. The toxicity profile was favorable, with the exception of grade 3-4 hypomagnesemia which was noted in 25% of patients.


CONCLUSIONS
High-dose cetuximab plus irinotecan rechallenge can re-elicit clinical benefits in patients who have previously failed cetuximab plus irinotecan treatment. The clinical benefits are modest and may be related to cetuximab rechallenge rather than cetuximab dose escalation.
A New Cost Effective Sensorless Commutation Method for Brushless DC Motors Without Phase Shift Circuit and Neutral Voltage

This paper presents the analysis, design, and implementation of a high performance and cost effective sensorless control scheme for the extensively used brushless dc motors. In an effort to decrease cost and increase ease of implementation, the commutation signals are obtained without the motor neutral voltage, multistage analog filters, A/D converters, or the complex digital phase shift (delay) circuits which are indispensable in the conventional sensorless control algorithms. In the proposed method, instead of detecting the zero crossing point of the nonexcited motor back electromagnetic force (EMF) or the average motor terminal to neutral voltage, the commutation signals are extracted directly from the specific average line to line voltages with simple RC circuits and comparators. In contrast to conventional methods, the neutral voltage is not needed; therefore, the commutation signals are insensitive to the common mode noise. Moreover, the complex phase shift circuit can be eliminated. As a result, the proposed control algorithm can be easily interfaced with the cost effective commercial Hall effect sensor based commutation integrated circuits. Due to its inherent low cost, the proposed control algorithm is particularly suitable for cost sensitive products such as air purifiers, air blowers, cooling fans, and related home appliances. Theoretical analysis and experiments are conducted over a wide operating speed range and different back EMF waveforms to justify the effectiveness of the proposed method
Learning similarity metrics for dynamic scene segmentation

This paper addresses the segmentation of videos with arbitrary motion, including dynamic textures, using novel motion features and a supervised learning approach. Dynamic textures are commonplace in natural scenes, and exhibit complex patterns of appearance and motion (e.g. water, smoke, swaying foliage). These are difficult for existing segmentation algorithms, often violate the brightness constancy assumption needed for optical flow, and have complex segment characteristics beyond uniform appearance or motion. Our solution uses custom spatiotemporal filters that capture texture and motion cues, along with a novel metric-learning framework that optimizes this representation for specific objects and scenes. This is used within a hierarchical, graph-based segmentation setting, yielding state-of-the-art results for dynamic texture segmentation. We also demonstrate the applicability of our approach to general object and motion segmentation, showing significant improvements over unsupervised segmentation and results comparable to the best task specific approaches.
Lower limb cellulitis and its mimics: part II. Conditions that simulate lower limb cellulitis.

Several common conditions can mimic cellulitis, creating a potential for misdiagnosis and incorrect management. The most common disorders mistaken for lower limb cellulitis include venous eczema, lipodermatosclerosis, irritant dermatitis, and lymphedema. The dermatologist is often consulted when a patient has failed to respond to therapy, and a thorough knowledge of the differential diagnosis is essential. This article focuses on entities that can mimic cellulitis, with an emphasis of elements of the history and physical examination that can help to distinguish between lower limb cellulitis and its simulators.
Relationship of serum bisphenol A with diabetes in the Thai population, National Health Examination Survey IV, 2009.

BACKGROUND
Epidemiological studies of the association between bisphenol A (BPA) exposure and diabetes have been inconsistent. The present study determined serum BPA concentrations in the Thai population and their association with hyperglycemia and diabetes.


METHODS
In all, 2581 serum samples from the Thai National Health Examination Survey (2009) were used to determine BPA levels. Impaired fasting glucose (IFG) was defined as fasting plasma glucose ≥100 and <126 mg/dL. Diabetes was defined as a history of a physician's diagnosis or fasting plasma glucose ≥126 mg/dL. Multinomial logistic regression was used to examine the association of serum BPA with IFG and diabetes.


RESULTS
Of 2581 samples tested, BPA was detected in 2135 samples (weighted percentage 78.1%), with a geometric mean concentration of 0.34 ng/mL BPA. Serum BPA levels were significantly higher among those with diabetes or IFG compared with normoglycemic individuals (0.52 and 0.38 vs 0.33 ng/mL, respectively; P < 0.001). After adjusting for potential confounders, compared with the first quartile (≤0.071 ng/mL), the overall adjusted odds ratios (OR) of serum BPA concentration in the third and fourth quartiles (0.319-0.745 and ≥0.746 ng/mL, respectively) for IFG were 1.72 (95% confidence interval [CI] 1.19, 2.49) and 1.23 (95% CI 0.80, 1.89), respectively; for diabetes, the adjusted OR were 1.88 (95% CI 1.18, 2.99) and 1.83 (95% CI 1.12, 2.95), respectively, with a slightly stronger association among men than in women.


CONCLUSIONS
Serum BPA concentrations were not associated with IFG, but were positively associated with diabetes in the Thai population. Further prospective studies are needed to confirm the relationship.