LLukas22/scidocs huggingface dataset:
Urinary cannabinoid detection times after controlled oral administration of delta9-tetrahydrocannabinol to humans.

BACKGROUND
Urinary cannabinoid excretion and immunoassay performance were evaluated by semiquantitative immunoassay and gas chromatography-mass spectrometry (GC/MS) analysis of metabolite concentrations in 4381 urine specimens collected before, during, and after controlled oral administration of tetrahydrocannabinol (THC).


METHODS
Seven individuals received 0, 0.39, 0.47, 7.5, and 14.8 mg THC/day in this double-blind, placebo-controlled, randomized, clinical study conducted on a closed research ward. THC doses (hemp oils with various THC concentrations and the therapeutic drug Marinol) were administered three times daily for 5 days. All urine voids were collected over the 10-week study and later tested by Emit II, DRI, and CEDIA immunoassays and by GC/MS. Detection rates, detection times, and sensitivities, specificities, and efficiencies of the immunoassays were determined.


RESULTS
At the federally mandated immunoassay cutoff (50 microg/L), mean detection rates were <0.2% during ingestion of the two low doses typical of current hemp oil THC concentrations. The two high doses produced mean detection rates of 23-46% with intermittent positive tests up to 118 h. Maximum metabolite concentrations were 5.4-38.2 microg/L for the low doses and 19.0-436 micro g/L for the high doses. Emit II, DRI, and CEDIA immunoassays had similar performance efficiencies of 92.8%, 95.2%, and 93.9%, respectively, but differed in sensitivity and specificity.


CONCLUSIONS
The use of cannabinoid-containing foodstuffs and cannabinoid-based therapeutics, and continued abuse of oral cannabis require scientific data for accurate interpretation of cannabinoid tests and for making reliable administrative drug-testing policy. At the federally mandated cannabinoid cutoffs, it is possible but unlikely for a urine specimen to test positive after ingestion of manufacturer-recommended doses of low-THC hemp oils. Urine tests have a high likelihood of being positive after Marinol therapy. The Emit II and DRI assays had adequate sensitivity and specificity, but the CEDIA assay failed to detect many true-positive specimens.
Breast cancer. Knowledge, attitudes and practices of breast self examination among women in Qassim region of Saudi Arabia.

OBJECTIVE
To determine the knowledge, attitudes and practices of women in Qassim region regarding breast self examination (BSE), and also to explore their level of knowledge regarding breast cancer.


METHODS
We conducted a cross-sectional survey during the period from May to June 2005, among Saudi female patients attending the Primary Health Care Centers of Qassim region. A total of 300 females, 20-70 years of age, were interviewed in 10 randomly selected primary health care centers.


RESULTS
The mean age of the participants was 36.2 +/- 10.2 years, and 70.7% of them were literate. Regarding the knowledge of risk factors, 76% of the respondents had 3 or more correct answers out of the total 7 questions. Twenty-six percent of the respondents did not know the presenting symptom of breast cancer. Whereas, 69.7% of the participants had never heard of BSE. The participants had a positive attitude towards learning BSE. Of the total respondents, 18.7% reported that they practice BSE, majority (57%) of whom had started performing it within the previous year. However, 74% of the respondents did not have access to breast health information.


CONCLUSION
This study concludes that the level of awareness of the females of Qassim region regarding breast cancer and BSE is not adequate and a health education program for this subject should be introduced in the region.
The effects of a whole grain-enriched hypocaloric diet on cardiovascular disease risk factors in men and women with metabolic syndrome.

BACKGROUND
Whole-grain foods are associated in observational studies with a lower body mass index and lower cardiovascular disease (CVD) risk. However, few clinical trials have tested whether incorporating whole grains into a hypocaloric diet increases weight loss and improves CVD risk factors.


OBJECTIVE
The aim of this study was to determine whether including whole-grain foods in a hypocaloric (reduced by 500 kcal/d) diet enhances weight loss and improves CVD risk factors.


DESIGN
Obese adults (25 M, 25 F) with metabolic syndrome were randomly assigned to receive dietary advice either to avoid whole-grain foods or to obtain all of their grain servings from whole grains for 12 wk. All participants were given the same dietary advice in other respects for weight loss.


RESULTS
Body weight, waist circumference, and percentage body fat decreased significantly (P<0.001) in both groups over the study period, but there was a significantly (P=0.03) greater decrease in percentage body fat in the abdominal region in the whole-grain group than in the refined-grain group. C-reactive protein (CRP) decreased 38% in the whole-grain group independent of weight loss but was unchanged in the refined-grain group (P=0.01 for group x time interaction). Total, LDL, and HDL cholesterol decreased in both diet groups (P<0.05). Dietary fiber and magnesium intakes increased in the whole-grain but not the refined-grain group (P=0.007 and P<0.001, respectively, for group x time interaction).


CONCLUSIONS
Both hypocaloric diets were effective means of improving CVD risk factors with moderate weight loss. There were significantly (P<0.05) greater decreases in CRP and percentage body fat in the abdominal region in participants consuming whole grains than in those consuming refined grains.
The JAK 2 V 617 F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia , but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia

Activating mutations in tyrosine kinases have been identified in hematopoietic and nonhematopoietic malignancies. Recently, we and others identified a single recurrent somatic activating mutation (JAK2V617F) in the Janus kinase 2 (JAK2) tyrosine kinase in the myeloproliferative disorders (MPDs) polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. We used direct sequence analysis to determine if the JAK2V617F mutation was present in acute myeloid leukemia (AML), chronic myelomonocytic leukemia (CMML)/atypical chronic myelogenous leukemia (aCML), myelodysplastic syndrome (MDS), B-lineage acute lymphoblastic leukemia (ALL), T-cell ALL, and chronic lymphocytic leukemia (CLL). Analysis of 222 patients with AML identified JAK2V617F mutations in 4 patients with AML, 3 of whom had a preceding MPD. JAK2V617F mutations were identified in 9 (7.8%) of 116 CMML/a CML samples, and in 2 (4.2%) of 48 MDS samples. We did not identify the JAK2V617F disease allele in B-lineage ALL (n 83), T-cell ALL (n 93), or CLL (n 45). These data indicate that the JAK2V617F allele is present in acute and chronic myeloid malignancies but not in lymphoid malignancies. (Blood. 2005; 106:3377-3379)
Count Your Eggs Before They Invade: Identifying and Quantifying Egg Clutches of Two Invasive Apple Snail Species (Pomacea)

Winning the war against invasive species requires early detection of invasions. Compared to terrestrial invaders, aquatic species often thrive undetected under water and do not garner notice until too late for early action. However, fortunately for managers, apple snails (Family Ampullariidae, Genus Pomacea) provide their own conspicuous sign of invasion in the form of vibrantly colored egg clutches. Managers can potentially use egg clutches laid in the riparian zone as a means of early detection and species identification. To facilitate such efforts, we quantified differences in characteristics (length, width, depth, mass, egg number) of field-laid clutches for the two most common invasive species of apple snail, P. canaliculata and P. maculata, in native and non-native populations. Pomacea canaliculata native and non-native populations differed noticeably only in width. Native P. maculata clutches possessed significantly greater width, mass and eggs numbers compared with native P. canaliculata. Non-native P. maculata clutches significantly exceeded all other populations in all measured characteristics. Consequently, these traits may successfully distinguish between species. Fecundity data also allowed us to develop models that accurately estimated the number of eggs per clutch for each species based on clutch dimensions. We tested one, two and three dimensional models of clutches, including rendering a clutch as either a complete ellipsoid or an ellipsoid intersected by a cylinder to represent the oviposition site. Model comparisons found the product of length and depth, with a different function for each population, best predicted egg number for both species. Comparisons of egg number to clutch volume and mass implied non-native P. canaliculata may be food limited, while non-native P. maculata appeared to produce such enormous clutches by having access to greater nutrients than the native population. With these new tools, researchers and managers can quickly identify, quantify and begin eradication of new non-native apple snail populations.
Transcriptional control of fleshy fruit development and ripening.

Fleshy fruits have evolved to be attractive to frugivores in order to enhance seed dispersal, and have become an indispensable part of the human diet. Here we review the recent advances in the understanding of transcriptional regulation of fleshy fruit development and ripening with a focus on tomato. While aspects of fruit development are probably conserved throughout the angiosperms, including the model plant Arabidopsis thaliana, it is shown that the likely orthologues of Arabidopsis genes have distinct functions in fleshy fruits. The model for the study of fleshy fruit development is tomato, because of the availability of single gene mutants and transgenic knock-down lines. In other species, our knowledge is often incomplete or absent. Tomato fruit size and shape are co-determined by transcription factors acting during formation of the ovary. Other transcription factors play a role in fruit chloroplast formation, and upon ripening impact quality aspects such as secondary metabolite content. In tomato, the transcription factors NON-RIPENING (NOR), COLORLESS NON-RIPENING (CNR), and RIPENING INHIBITOR (MADS-RIN) in concert with ethylene signalling regulate ripening, possibly in response to a developmental switch. Additional components include TOMATO AGAMOUS-LIKE1 (TAGL1), APETALA2a (AP2a), and FRUITFULL (FUL1 and FUL2). The links between this highly connected regulatory network and downstream effectors modulating colour, texture, and flavour are still relatively poorly understood. Intertwined with this network is post-transcriptional regulation by fruit-expressed microRNAs targeting several of these transcription factors. This important developmental process is also governed by changes in DNA methylation levels and possibly chromatin remodelling.
Ocimum gratissimum: A Review of its Chemical, Pharmacological andEthnomedicinal Properties

Ocimum gratissimum is a well-known plant used in the Indian system of medicine. Folklore medicine claims its use in headache, fever, diarrhoea, pneumonia etc. Research carried out using different in vitro and in vivo techniques of biological evaluation supports most of the claims. This review presents the ethnobotanical, natural product chemistry, pharmacological, clinical and toxicological data of the plant.
Probabilistic multi-class segmentation for the Amazon Picking Challenge

We present a method for multi-class segmentation from RGB-D data in a realistic warehouse picking setting. The method computes pixel-wise probabilities and combines them to find a coherent object segmentation. It reliably segments objects in cluttered scenarios, even when objects are translucent, reflective, highly deformable, have fuzzy surfaces, or consist of loosely coupled components. The robust performance results from the exploitation of problem structure inherent to the warehouse setting. The proposed method proved its capabilities as part of our winning entry to the 2015 Amazon Picking Challenge. We present a detailed experimental analysis of the contribution of different information sources, compare our method to standard segmentation techniques, and assess possible extensions that further enhance the algorithm's capabilities. We release our software and data sets as open source.
Strontium ranelate phase 2 dose-ranging studies: PREVOS and STRATOS studies

 The aim of the PREVOS study (PREVention Of early postmenopausal bone loss by Strontium ranelate) and the STRATOS study (STRontium Administration for Treatment of OSteoporosis) was to determine the minimum dose at which strontium ranelate (SR) is effective in, respectively, the prevention of bone loss in early postmenopausal nonosteoporotic women and the treatment of postmenopausal vertebral osteoporosis. Both studies were randomized, double-blind, placebo-controlled, dose-finding studies in parallel groups and lasted 2 years. In the PREVOS study, 160 early postmenopausal women were randomized to receive placebo, SR 125 mg/day, 500 mg/day or 1 g/day. In the STRATOS study, 353 osteoporotic postmenopausal women with at least one previous vertebral fracture and a lumbar T-score <−2.4 were randomized to receive placebo, SR 500 mg/day, 1 g/day or 2 g/day. In both studies, the primary efficacy parameter was lumbar bone mineral density (BMD) measured by dual-energy X-ray absorptiometry. Secondary efficacy criteria included incidence of new vertebral deformities (in the STRATOS study only) and biochemical markers of bone metabolism. In the PREVOS study, the increase in lumbar BMD from baseline in the 1 g/day group (+5.53%) was significantly different from the decrease in the placebo group (p<0.001). In the STRATOS study, the annual increase in lumbar BMD in the 2 g/day group (+7.3% per year) was significantly higher than in the placebo group (p<0.001). There was a significant reduction in the number of patients experiencing new vertebral deformities in the second year of treatment in the 2 g/day group (relative risk: 0.56; 95% confidence interval: 0.35, 0.89). In both studies, there was a significant increase in the bone formation marker (bone alkaline phosphatase) in the higher-dose group. Urinary excretion of the marker of bone resorption (cross-linked N-telopeptide) was lower with SR than with placebo in the STRATOS study. SR was very well tolerated in both studies. The minimum dose at which SR is effective in preventing bone loss in early postmenopausal nonosteoporotic women and in the treatment of postmenopausal osteoporosis is 1 g/day and 2 g/day, respectively.
Uses and Gratifications Theory in the 21st Century

Some mass communications scholars have contended that uses and gratifications is not a rigorous social science theory. In this article, I argue just the opposite, and any attempt to speculate on the future direction of mass communication theory must seriously include the uses and gratifications approach. In this article, I assert that the emergence of computer-mediated communication has revived the significance of uses and gratifications. In fact, uses and gratifications has always provided a cutting-edge theoretical approach in the initial stages of each new mass communications medium: newspapers, radio and television, and now the Internet. Although scientists are likely to continue using traditional tools and typologies to answer questions about media use, we must also be prepared to expand our current theoretical models of uses and gratifications. Contemporary and future models must include concepts such as interactivity, demassification, hypertextuality, and asynchroneity. Researchers must also be willing to explore interpersonal and qualitative aspects of mediated communication in a more holistic methodology.
The effects of magnetic fields on plant growth and health

De Souza et al. showed that the growth and yield of lettuce could be improved by treatment of its seeds before they were grown, using rectified sinusoidal non-uniform electromagnetic fields.[1] It was observed that magnetism has effects on lettuce at the nursery, vegetative, and maturity stages, including a significant increase in root length and shoot height, a greater growth rate, and a significant increase in plant height, leaf area, and fresh mass. Positive biological effects of magnetism on sunflower and wheat seedlings weights were reported.[2] Further data show that the magnetic field induced by the voltage of a specific waveform enhanced or inhibited mung bean growth, depending on the frequencies,[3] which suggests that the magnetic field on plant growth may be sensitive to the waveform and frequency of the source electrical voltage. The effect of static magnetic field on plant growth has also been studied. Cakmak et al. found that static magnetic field accelerated germination and early growth of wheat and bean seeds.[4] Vashisth et al. obtained similar results with chickpeas; furthermore, they found that the responses of the plant to static magnetic field varied with field strength and duration of exposure with no particular trend.[5] However, as indicated by a literature review, weak magnetic field exhibited negative effects on plant growth, such as inhibition of primary root growth, in some cases.[6] For instance, exposure to magnetic field inhibited early growth of radish seedlings with decrease in the weight and leaf area.[7] An interesting result is that the biological effect of a magnetic field is different between the south and north poles, as illustrated by a study, which showed that radish seedlings had a significant tropic response to the south pole of the magnet, but insignificant response to the north pole. [7] It is theorized that the south pole of the magnet enhances plant and bacterial A study was conducted to test the hypothesis that a magnetic field can affect plant growth and health. The study divided plants into three groups. The first group of plant seeds grew in a low magnetic field. The second group grew in a high magnetic field. The third group grew in the absence of a magnetic field, serving as a control group. Several growth parameters were measured, including the germination rate, plant height, and leaf size. In addition, the health status was measured by leaf color, spots, the stem curvature, and the death rate. Plant growth was observed continuously for four weeks. The results showed that magnetism had a significant positive effect on plant growth. Plant seeds under the influence of the magnetic field had a higher germination rate, and these plants grew taller, larger, and healthier than those in the control group. No adverse effects of magnetism on plant growth were noticed. However, the removal of the magnetic field weakened the plant stem, suggesting the role of magnetism in supplying plants with energy. Edward Fu
Abnormal behavior detection using hybrid agents in crowded scenes

Please save a copy of this file, complete and upload as the " Confirmation of Authorship " file. 1. This manuscript, or a large part of it, has not been published, was not, and is not being submitted to any other journal. If presented at a conference, the conference is identified. If published in conference proceedings, the publication is identified below and substantial justification for re-publication must be presented. 2. All text and graphics, except for those marked with sources, are original works of the authors, and all necessary permissions for publication were secured prior to submission of the manuscript. 3. All authors each made a significant contribution to the research reported and have read and approved the submitted manuscript. 1. The sentence in lines 266-269 is still not properly written. Please correct to something like "Since SFM only uses interaction information between neighbor agents to detect abnormal behavior, it is not productive to detect abnormal behavior when the interaction among neighbors is not represented by the behavior of foreground objects." Answer) We rephrase the statement according to reviewer's comments Before) Since SFM is only used interaction information between neighbor agents to detect abnormal behavior, it is not productive to detect abnormal behavior when the interaction among neighbors is not represented by the behavior of foreground objects. After) Since SFM only uses interaction information between neighbor agents to detect abnormal behavior, it is not productive to detect abnormal behavior when the interaction among neighbors is not represented by the behavior of foreground objects. 2. Please include in the caption of figure 6 the methods to which the red and blue lines refer to. Answer) We modified the caption in figure 6 as follows (a) PETS 2009 dataset (b) UCSD 2009 dataset Fig. 6. Results of abnormal behavior detection in two datasets (Red line : SFM, Blue line: our method). • We categorize the behaviors of people into individual and group interactive behavior. • We propose a hybrid agent system that includes static and dynamic agents in a scene. • We represent the behavior of a crowd as a bag of words to detect abnormal behavior. *Manuscript [Word or (La)TeX] Click here to download Manuscript [Word or (La)TeX]: paper_revision_final.docx Click here to view linked References Abstract 26 In this paper, we propose a hybrid agent method to detect abnormal behaviors in a crowded 27 scene. In real-life situations, abnormal behavior occurs …
Making the Transition: Helping Teachers To Teach Online.

Teaching in the cyberspace classroom requires moving beyond old models of. pedagogy into new practices that are more facilitative. It involves much more than simply taking old models of pedagogy and transferring them to a different medium. Unlike the face-to-face classroom, in online distance education, attention needs to be paid to the development of a sense of community within the group of participants in order for the learning process to be successful. The transition to the cyberspace classroom can be successfully achieved if attention is paid to several key areas. These include: ensuring access to and familiarity with the technology in use; establishing guidelines and procedures which are relatively loose and free-flowing, and generated with significant input from participants; striving to achieve maximum participation and "buy-in" from the participants; promoting collaborative learning; and creating a double or triple loop in the learning process to enable participants to reflect on their learning process. All of these practices significantly contribute to the development of an online learning community, a powerful tool for enhancing the learning experience. Each of these is reviewed in detail in the paper. (AEF) Reproductions supplied by EDRS are the best that can be made from the original document. Making the Transition: Helping Teachers to Teach Online Rena M. Palloff, Ph.D. Crossroads Consulting Group and The Fielding Institute Alameda, CA