LLukas22/scidocs huggingface dataset:
Comparative use of biomedical services and traditional healing options by American Indian veterans.

OBJECTIVE
This study described service use among American Indian veterans, compared use patterns across biomedical care and traditional healing options, and tested whether utilization varied as a function of need or availability.


METHODS
A cross-sectional survey of 621 male combat veterans selected from tribal rolls was conducted between 1992 and 1995 in American Indian reservation communities in the Southwest and in the Northern Plains. Measures included assessments of demographic characteristics, physical and mental health conditions, and self-reports of any use during the past year of Veterans Administration (VA), Indian Health Service (IHS), and other biomedical services as well as participation in traditional ceremonies and use of indigenous healing options.


RESULTS
Tribal groups were similar in sociodemographic characteristics and in number of health problems and mental and substance use problems during the past year. The same types of services from IHS were available to the two groups, and the geographic distance to these services was similar. VA facilities were more readily available in the Northern Plains than in the Southwest, where they were far from reservation boundaries. Use of IHS services was similar for the two tribal groups, but use of VA services was significantly less in the Southwest. Overall, biomedical services were used more in the Northern Plains, reflecting greater use of VA facilities. However, these differences in overall health service disappeared when traditional healing options were considered. Use of traditional healing was greater in the Southwest, offsetting lower biomedical service use.


CONCLUSIONS
When the full array of options is examined, service use functions according to need for health care, but the kind of services used varies according to availability.
MAC-RANSAC : a robust algorithm for the recognition of multiple objects

This paper addresses the problem of recognizing multiple rigid objects that are common to two images. We propose a generic algorithm that allows to simultaneously decide if one or several objects are common to the two images and to estimate the corresponding geometric transformations. The considered transformations include similarities, homographies and epipolar geometry. We first propose a generalization of an a contrario formulation of the RANSAC algorithm proposed in [6]. We then introduce an algorithm for the detection of multiple transformations between images and show its efficiency on various experiments.
On Modeling of Lifetimes Data Using Exponential and

In this paper, firstly the nature of exponential and Lindley distributions have been studied using different graphs of their probability density functions and cumulative distribution functions. The expressions for the index of dispersion for both exponential and Lindley distributions have been obtained and the conditions under which the exponential and Lindley distributions are over-dispersed, equidispersed, and under-dispersed has been given. Several real lifetimes data-sets has been fitted using exponential and Lindley distributions for comparative study and it has been shown that in some cases exponential distribution provides better fit than the Lindley distribution whereas in other cases Lindley distribution provides better fit than the exponential distribution.
Surface roughness monitoring application based on artificial neural networks for ball-end milling operations

Surface roughness plays an important role in the performance of a finished part. The roughness is usually measured off-line when the part is already machined, although in recent years the trend seems to have been to focus on online monitoring. Measuring and controlling the machining process is now possible thanks to improvements and advances in the fields of computers and sensors. The aim of this work was to develop a reliable surface roughness monitoring application based on an artificial neural network approach for vertical high speed milling operations. Experimentation was carried out to obtain data that was used to train the artificial neural network. Geometrical cutting factors, dynamic factors, part geometries, lubricants, materials and machine tools were all considered. Vibration was captured on line with two piezoelectric accelerometers placed following the X and Y axes of the machine tool.
Characteristics and outcomes of older HIV-infected patients receiving antiretroviral therapy in Malawi: A retrospective observation cohort study

OBJECTIVE
To estimate patients enrolling on antiretroviral therapy (ART) over time; describe trends in baseline characteristics; and compare immunological response, loss to follow-up (LTFU), and mortality by three age groups (25-39, 40-49 and ≥50 years).


DESIGN
A retrospective observation cohort study.


METHODS
This study used routine ART data from two public clinics in Lilongwe, Malawi. All HIV-infected individuals, except pregnant or breastfeeding women, aged ≥ 25 years at ART initiation between 2006 and 2015 were included. Poisson regression models estimated risk of mortality, stratified by age groups.


RESULTS
Of 37,378 ART patients, 3,406 were ≥ 50 years old. Patients aged ≥ 50 years initiated ART with more advanced WHO clinical stage and lower CD4 cell count than their younger counterparts. Older patients had a significantly slower immunological response to ART in the first 18 months on ART compared to patients aged 25-39 years (p = 0.04). Overall mortality rates were 2.3 (95% confidence Interval (CI) 2.2-2.4), 2.9 (95% CI 2.7-3.2) and 4.6 (95% CI 4.2-5.1) per 100 person-years in patients aged 25-39 years, 40-49 years and 50 years and older, respectively. Overall LTFU rates were 6.3 (95% CI 6.1-6.5), 4.5 (95% CI 4.2-4.7), and 5.6 (95% CI 5.1-6.1) per 100 person years among increasing age cohorts. The proportion of patients aged ≥ 50 years and newly enrolling into ART care remained stable at 9% while the proportion of active ART patients aged ≥50 years increased from 10% in 2006 to 15% in 2015.


CONCLUSION
Older people had slower immunological response and higher mortality. Malawi appears to be undergoing a demographic shift in people living with HIV. Increased consideration of long-term ART-related problems, drug-drug interactions and age-related non-communicable diseases is warranted.
Cleanliness audit of clinical surfaces and equipment: who cleans what?

Current guidelines recommend regular cleaning of clinical equipment. We monitored items on a surgical ward for predominant user, hand-touch frequency, cleaning responsibilities and measurement of organic soil. Equipment was assessed in triplicate against a cleanliness benchmark of 100 relative light units (RLU) using the Hygiena® ATP system. There were 44 items, of which 21 were cleaned by clinical support workers (CSWs), five by domestic staff; three by nurses, three by doctors, and 12 with no designated cleaning responsibility. Geometric mean RLUs ranged from 60 to 550/100 cm² for small items such as hand-gel containers, bed control, blood pressure cuff and clinical notes; with similar values of 80-540/100 cm² RLU for larger items such as electrocardiogram machine, defibrillator, trolleys and tables. Overall geometric mean was 249/100 cm² RLU for all surfaces, with 84% (37 of 44) items exceeding the 100RLU benchmark. Of 27 items cleaned by clinical staff, 24 (89%) failed the benchmark. Of 12 sites with no cleaning specification, 11 (92%) failed the benchmark. Three of seven 'clean' sites (<100/100 cm² RLU) were cleaned by domestic staff. Average log(10) RLU of surfaces cleaned by domestics were 64% lower compared with surfaces cleaned by CSWs (95% confidence interval: 35%, 80%; P=0.019). In conclusion, clinical equipment frequently demonstrates high levels of organic soil, whether or not items have assigned cleaning responsibility. These findings suggest that cleaning practices for clinical equipment may require review, along with education of staff with specific cleaning responsibilities.
Co-prescription of cytochrome P450 2D6/3A4 inhibitor-substrate pairs in clinical practice. A retrospective analysis of data from Norwegian primary pharmacies

Inhibition of cytochrome P P450 (CYP) enzymes, in particular CYP3A4 and CYP2D6, is an important drug-interacting mechanism. The objective of our study was to assess how frequently CYP3A4 and CYP2D6 inhibitors are co-prescribed with substrates of the respective enzymes. Included inhibitors were clarithromycin, erythromycin, fluconazole, itraconazole, ketoconazole and nefazodone (CYP3A4 inhibitors) and bupropion, fluoxetine, paroxetine and terbinafine (CYP2D6 inhibitors). The inhibitors were combined with substrates shown to be pharmacokinetically sensitive towards inhibition (190 drug pairs in total). Lists of patients receiving inhibitors and substrates were drawn from prescription databases (~43,500 patients) of three Norwegian primary pharmacies during a 6-month period (July 2002 to January 2003). The lists were matched on name and date of birth to identify patients using drug pairs. Concurrent use was made probable from dates of purchase and drug profiles. Inhibitors were prescribed to 2,062 patients. Altogether, 369 events of substrate co-prescription were registered. The highest frequencies of co-prescribed substrates were found for paroxetine (101 events per 267 patients, 38%), fluoxetine (36 events per 110 patients, 33%) and clarithromycin (59 events per 242 patients, 24%). The drugs most often detected in combination with inhibitors were codeine (116 events) and metoprolol (38 events) for CYP2D6 and zopiclone (45 events) and simvastatin (26 events) for CYP3A4. Several commonly used CYP2D6 and CYP3A4 inhibitors are frequently co-prescribed with substrates in Norwegian clinical practice. Alertness when inhibitors are prescribed would aid physicians and pharmacists to detect many drug combinations with potential interaction risk.
Joint Morphological and Syntactic Analysis for Richly Inflected Languages

Joint morphological and syntactic analysis has been proposed as a way of improving parsing accuracy for richly inflected languages. Starting from a transition-based model for joint part-of-speech tagging and dependency parsing, we explore different ways of integrating morphological features into the model. We also investigate the use of rule-based morphological analyzers to provide hard or soft lexical constraints and the use of word clusters to tackle the sparsity of lexical features. Evaluation on five morphologically rich languages (Czech, Finnish, German, Hungarian, and Russian) shows consistent improvements in both morphological and syntactic accuracy for joint prediction over a pipeline model, with further improvements thanks to lexical constraints and word clusters. The final results improve the state of the art in dependency parsing for all languages.
Subcutaneous Ustekinumab Provides Clinical Benefit for Two-Thirds of Patients With Crohn's Disease Refractory to Anti-Tumor Necrosis Factor Agents.

BACKGROUND & AIMS
Ustekinumab, a human monoclonal antibody against the p40 subunit of interleukins-12 and -23, is effective in inducing and maintaining remission in patients with luminal Crohn's disease (CD). We assessed the efficacy and safety of subcutaneous ustekinumab in patients with anti-tumor necrosis factor (anti-TNF) refractory CD.


METHODS
We performed a retrospective observational study, collecting data from the Groupe d'Etude Thérapeutique des Affections Inflammatoires du tube Digestif on 122 consecutive patients with active CD refractory to anti-TNF therapy who received at least 1 subcutaneous injection of ustekinumab from March 2011 to December 2014, in 20 tertiary centers in Europe. Subjects were followed for at least 3 months. The primary outcome was clinical benefit, defined as reductions in symptoms and biochemical markers of CD and complete weaning from steroids, without surgery or immunosuppressant therapies.


RESULTS
Seventy-nine patients (65%) had a clinical benefit within 3 months of receiving ustekinumab. Concomitant immunosuppressant therapy at study inclusion increased the odds for a clinical benefit from ustekinumab (odds ratio, 5.43; 95% confidence interval, 1.14-25.77; P = .03). Over a median follow-up period of 9.8 months (interquartile range, 5.3-14.5 months), the cumulative probabilities that patients maintained the clinical benefit for 6 and 12 months after introduction of ustekinumab were 93% and 68%, respectively.


CONCLUSIONS
Almost two-thirds of patients with CD refractory to at least 1 anti-TNF agent receive clinical benefit from ustekinumab therapy, not requiring steroids for up to 12 months afterward. While awaiting results from ongoing trials, ustekinumab can be considered for use in these patients.
A 3D Shape Retrieval Framework Supporting Multimodal Queries

This paper presents a unified framework for 3D shape retrieval. The method supports multimodal queries (2D images, sketches, 3D objects) by introducing a novel view-based approach able to handle the different types of multimedia data. More specifically, a set of 2D images (multi-views) are automatically generated from a 3D object, by taking views from uniformly distributed viewpoints. For each image, a set of 2D rotation-invariant shape descriptors is produced. The global shape similarity between two 3D models is achieved by applying a novel matching scheme, which effectively combines the information extracted from the multi-view representation. The experimental results prove that the proposed method demonstrates superior performance over other well-known state-of-the-art approaches.
A Survey of Nonlinear Attitude Estimation Methods

This paper provides a survey of modern nonlinear filtering methods for attitude estimation. Early applications relied mostly on the extended Kalman filter for attitude estimation. Since these applications, several new approaches have been developed that have proven to be superior to the extended Kalman filter. Several of these approaches maintain the basic structure of the extended Kalman filter, but employ various modifications in order to provide better convergence or improve other performance characteristics. Examples of such approaches include: filter QUEST, extended QUEST and the backwards-smoothing extended Kalman filter. Filters that propagate and update a discrete set of sigma points rather than using linearized equations for the mean and covariance are also reviewed. A twostep approach is discussed with a first-step state that linearizes the measurement model and an iterative second step to recover the desired attitude states. These approaches are all based on the Gaussian assumption that the probability density function is adequately specified by its mean and covariance. Other approaches that do not require this assumption are reviewed, Associate Professor, Department of Mechanical & Aerospace Engineering. Email: johnc@eng.buffalo.edu. Associate Fellow AIAA. Aerospace Engineer, Guidance, Navigation and Control Systems Engineering Branch. Email: Landis.Markley@nasa.gov. Fellow AIAA. Postdoctoral Research Fellow, Department of Mechanical & Aerospace Engineering. Email: cheng3@eng.buffalo.edu. Member AIAA.
Randomized controlled trial of aerobic exercise on insulin and insulin-like growth factors in breast cancer survivors: the Yale Exercise and Survivorship study.

BACKGROUND
High insulin and insulin-like growth factor-I (IGF-I) levels may be associated with an increased breast cancer risk and/or death. Given the need to identify modifiable factors that decrease insulin, IGF-I, and breast cancer risk and death, we investigated the effects of a 6-month randomized controlled aerobic exercise intervention versus usual care on fasting insulin, IGF-I, and its binding protein (IGFBP-3) in postmenopausal breast cancer survivors.


METHODS
Seventy-five postmenopausal breast cancer survivors were identified from the Yale-New Haven Hospital Tumor Registry and randomly assigned to an exercise (n = 37) or usual care (n = 38) group. The exercise group participated in 150 minutes per week of moderate-intensity aerobic exercise. The usual care group was instructed to maintain their current physical activity level. A fasting blood sample was collected on each study participant at baseline and 6 months. Blood levels of insulin and IGF were measured with ELISA.


RESULTS
On average, exercisers increased aerobic exercise by 129 minutes per week compared with 45 minutes per week among usual care participants (P < 0.001). Women randomized to exercise experienced decreases in insulin, IGF-I, and IGFBP-3, whereas women randomized to usual care had increases in these hormones. Between-group differences in insulin, IGF-I, and IGFBP-3 were 20.7% (P = 0.089), 8.9% (P = 0.026), and 7.9% (P = 0.006), respectively.


CONCLUSIONS
Moderate-intensity aerobic exercise, such as brisk walking, decreases IGF-I and IGFBP-3. The exercise-induced decreases in IGF may mediate the observed association between higher levels of physical activity and improved survival in women diagnosed with breast cancer.
A multinational, multi-centre, observational, cross-sectional survey assessing diabetes secondary care in Central and Eastern Europe (DEPAC Survey).

AIMS
The objective of this study was to assess diabetes care in outpatient diabetes clinics in the Czech Republic, Estonia, Hungary, Latvia, Lithuania, Poland, Slovakia and Slovenia.


METHODS
Questionnaires for each randomly enrolled patient were completed by an endocrinologist or diabetologist. Data concerning age, sex, diabetes duration, diabetes type, treatment type, glycated haemoglobin (HbA(1c)), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG) and high-density lipoprotein cholesterol (HDL-C), blood pressure (BP) and short- and long-term diabetes complications were recorded. Questionnaires were analysed centrally for each country and stratified for Type 1 diabetes (T1D), Type 2 diabetes (T2D) and other types of diabetes.


RESULTS
Data on 10 950 individuals were analysed (mean population age 56.2 years; females 52%; T1D 22.9%; T2D 75.3%; mean time from diagnosis 11 years). Patients with HbA(1c) within target (< 6.5%): T1D 13.1%, T2D 21.4%; for TC levels (< 4.5 mmol/l): T1D 37%, T2D 20%; for TG levels (< 1.7 mmol/l): T1D 78%, T2D 44%; for HDL-C (> 1.1 mmol/l): T1D 81%, T2D 60%; for LDL-C (< 2.5 mmol/l): T1D 36%, T2D 23%; for BP (< 130/80 mm Hg): T1D 42%, T2D 9%. The prevalence of severe hypoglycaemia (within the last 6 months) was 12% in T1D and 2% in T2D. Prevalence of diabetic ketoacidosis was 0.3-6.6%, blindness 0.15-1.3% and diabetic nephropathy 19-42%.


CONCLUSIONS
The data show the current quality of care and potential areas for improvement. The quality of care is generally comparable with that in Western Europe.
Research on WNN Modeling for Gold Price Forecasting Based on Improved Artificial Bee Colony Algorithm

Gold price forecasting has been a hot issue in economics recently. In this work, wavelet neural network (WNN) combined with a novel artificial bee colony (ABC) algorithm is proposed for this gold price forecasting issue. In this improved algorithm, the conventional roulette selection strategy is discarded. Besides, the convergence statuses in a previous cycle of iteration are fully utilized as feedback messages to manipulate the searching intensity in a subsequent cycle. Experimental results confirm that this new algorithm converges faster than the conventional ABC when tested on some classical benchmark functions and is effective to improve modeling capacity of WNN regarding the gold price forecasting scheme.
Public beliefs about and attitudes towards people with mental illness: a review of population studies.

OBJECTIVE
To provide a review of population-based attitude research in psychiatry during the past 15 years.


METHOD
An electronic search using PubMed, Medline, and Academic Search Premier plus a hand search of the literature was carried out for studies on public beliefs about mental illness and attitudes towards the mentally ill published between 1990 and 2004.


RESULTS
Thirty-three national studies and 29 local and regional studies were identified, mostly from Europe. Although the majority are of descriptive nature, more recent publications include studies testing theory-based models of the stigmatization of mentally ill people, analyses of time trends and cross-cultural comparisons, and evaluations of antistigma interventions.


CONCLUSION
Attitude research in psychiatry made considerable progress over the past 15 years. However, there is still much to be done to provide an empirical basis for evidence-based interventions to reduce misconceptions about mental illness and improve attitudes towards persons with mental illness.
Friction Compensation of Harmonic Drive Actuators

Friction models and methods of friction compensation as app lied to harmonic drive servo-actuators are investigated. In the absence of output torque measurements and output shaft encoder data nearly complete friction compens ation is achieved. Simulation and experimental results showing the application of the friction compensation are given. Introduction Because of the absence of backlash and high gear ratios servo -actuators with harmonic drive gearing are commonly used for space manipulator s. One of their major drawbacks is their high levels of internal friction. In addi tion to the friction caused by the DC-motor brushes and the bearings, the harmonic drive gearing in the actuators causes a major part of the total friction due to the flex-s pline and the large gear tooth area. The friction is nonlinear and is dependent on the s ate of the motor and its environment. A wide range of friction models have been th oroughly reviewed by Armstrong-H́elouvry et al.[1] and Olssonet al.[2]. The ubiquitous Coulomb friction model and its simple extensions have difficulties when t he velocity is near zero because of the jump discontinuity in that region. A more gene ral model of friction is
Reliability and validity of the Manual Function Test in patients with stroke.

OBJECTIVE
The Manual Function test (MFT) is an upper-limb function assessment measure for hemiparetic patients after stroke. This study represents the reliability and validity of the MFT.


DESIGN
Ninety patients within half a year after stroke onset were hospitalized from August 2005 through November 2006. Test-retest reliability, interrater reliability, and internal consistency reliability of MFT were investigated. Validity of the MFT was evaluated with the Brunnstrom Stage, the Stroke Impairment Assessment Set, and the Barthel Index.


RESULTS
The test-retest reliability coefficient and interrater reliability of the MFT were consistently above 0.95. Cronbach's alpha coefficient as internal consistency of eight items was also 0.95. With respect to the validity of the MFT, it had a correlation of >0.8 with both the Brunnstrom Stage and the Stroke Impairment Assessment Set. The correlation among task items within each category was also high. There was a higher correlation (rho = 0.647) between the MFT and Barthel Index. Among the Barthel Index items, "dressing" had the highest correlation with the MFT, which indicates that upper-limb functions and degree of independence in dressing are highly correlated.


CONCLUSIONS
It was concluded that the MFT offers reliable and valid methods for assessing for upper-limb functional disorders.