LLukas22/scidocs huggingface dataset:
Characterization of SOA in Time Domain and the Improvement Techniques for Using in High-Voltage Integrated Circuits

Safe operating area (SOA) in power semiconductors is one of the most important factors affecting device reliability. The SOA region of power MOSFETs must be well characterized for using in circuit design to meet the specification of applications, particularly including the time domain of circuit operations. In this paper, the characterization of SOA in the time domain is performed with the experimental measurement on silicon devices, and the useful techniques to improve SOA of power MOSFETs for using in high-voltage integrated circuits are overviewed.
Dual gold nanoparticle lateflow immunoassay for sensitive detection of Escherichia coli O157:H7.

Two patterns of signal amplification lateral flow immunoassay (LFIA), which used anti-mouse secondary antibody-linked gold nanoparticle (AuNP) for dual AuNP-LFIA were developed. Escherichia coli O157:H7 was selected as the model analyte. In the signal amplification direct LFIA method, anti-mouse secondary antibody-linked AuNP (anti-mouse-Ab-AuNP) was mixed with sample solution in an ELISA well, after which it was added to LFIA, which already contained anti-E. coli O157:H7 monoclonal antibody-AuNP (anti-E. coli O157:H7-mAb-AuNP) dispersed in the conjugate pad. Polyclonal antibody was the test line, and anti-mouse secondary antibody was the control line in nitrocellulose (NC) membrane. In the signal amplification indirect LFIA method, anti-mouse-Ab-AuNP was mixed with sample solution and anti-E. coli O157:H7-mAb-AuNP complex in ELISA well, creating a dual AuNP complex. This complex was added to LFIA, which had a polyclonal antibody as the test line and secondary antibody as the control line in NC membrane. The detection sensitivity of both LFIAs improved 100-fold and reached 1.14×10(3) CFU mL(-1). The 28 nm and 45 nm AuNPs were demonstrated to be the optimal dual AuNP pairs. Signal amplification LFIA was perfectly applied to the detection of milk samples with E. coli O157:H7 via naked eye observation.
Weekly 5-fluorouracil and leucovorin: achieving lower toxicity with higher dose-intensity in adjuvant chemotherapy after colorectal cancer resection.

BACKGROUND
Current standard therapy following resection of high-risk colon cancer is intravenous bolus 5-fluorouracil (5-FU) with leucovorin (LV), but there is no consensus on the optimum regimen of these drugs: practice ranges from the high toxicity Mayo Clinic schedule to the very low toxicity weekly QUASAR schedule. We present data for a weekly schedule that aims to provide moderately dose-intense treatment with low toxicity.


PATIENTS AND METHODS
One hundred and sixty-two patients were studied: 60% male; median age 65 years (36% over 70 years); 94% colorectal primary. Treatment was intravenous bolus (5 min) 5-FU 425 mg/m(2) plus D,L-LV 45 mg flat rate once weekly, for a planned 24 weeks. Data for toxicity, dose-reductions, delays and stoppages were collected.


RESULTS
Overall, 20% of patients experienced any grade > or = 3 toxicity, most commonly diarrhoea (14% patients). Dose reductions were made in 35% of patients (although only 21% required 20% or more reduction); toxicity contributed to a decision to stop treatment before 24 weeks in 16% of patients. Median delivered dose intensity (DI) was 96% of planned (407 mg/m(2)/week) during treatment, and 91% of planned (385 mg/m(2)/week) over the full 24 week treatment plan. Female sex and age >70 years were significantly associated with higher rates of toxicity and dose adjustment, and lower delivered DI.


CONCLUSIONS
Weekly treatment at these doses is convenient and well-tolerated for the large majority of patients, and achieves DI comparable with the 5 days a month QUASAR schedule and other more toxic standard regimens.
Giving computers a nose for news: exploring the limits of story detection and verification

The use of social media as a source of news is entering a new phase as computer algorithms are developed and deployed to detect, rank, and verify news. The efficacy and ethics of such technology are the subject of this article, which examines the SocialSensor application, a tool developed by a multidisciplinary EU research project. The results suggest that computer software can be used successfully to identify trending news stories, allow journalists to search within a social media corpus, and help verify social media contributors and content. However, such software also raises questions about accountability as social media is algorithmically filtered for use by journalists and others. Our analysis of the inputs SocialSensor relies on shows biases towards those who are vocal and have an audience, many of whom are men in the media. We also reveal some of the technology's temporal and topic preferences. The conclusion discusses whether such biases are necessary for systems like SocialSensor to be effective. The article also suggests that academic research has failed to fully recognise the changes to journalists' sourcing practices brought about by social media, particularly Twitter, and provides some countervailing evidence and an explanation for this failure. Introduction The ubiquity of computing in contemporary culture has resulted in human decision-making being augmented, and even partially replaced, by computational processes or algorithms using artificial intelligence and information-retrieval techniques. Such augmentation and substitution is already common, and even predominates, in some industries, such as financial trading and legal research. Frey and Osborne (2013) have attempted to predict the extent to which a wide spectrum of jobs is susceptible to computerisation. Although journalists were not included in their analysis, some of the activities undertaken by journalists—for example those carried out by interviewers, proofreaders, and copy markers—were, and had a greater than 50 per cent probability of being computerised. It is that potential for the automation of journalistic work that is explored in this article. Frey and Osborne remind us of how automation can be aggressively resisted by workers, giving the example of William Lee who, they say, was driven out of Britain by the guild of hosiers for inventing a machine that knitted stockings. Such resistance also exists in the context of journalistic automation. For example, the German Federation of Journalists have said they " don't think it is … desirable that journalism is done with algorithms " (Konstantin Dörr, personal communication, 6 February …
Robust end-to-end deep audiovisual speech recognition

Speech is one of the most effective ways of communication among humans. Even though audio is the most common way of transmitting speech, very important information can be fou nd in other modalities, such as vision. Vision is particularly us ef l when the acoustic signal is corrupted. Multi-modal speech recog nition however has not yet found wide-spread use, mostly because th e temporal alignment and fusion of the different information sources is challenging. This paper presents an end-to-end audiovisual speech recog nizer (AVSR), based on recurrent neural networks (RNN) with a conn ectionist temporal classification (CTC) [1] loss function. CTcreates sparse “peaky” output activations, and we analyze the diffe rences in the alignments of output targets (phonemes or visemes) be tween audio-only, video-only, and audio-visual feature represe ntations. We present the first such experiments on the large vocabulary IB M ViaVoice database, which outperform previously published ap proaches on phone accuracy in clean and noisy conditions.
Silicon-Controlled Rectifier for Electrostatic Discharge Protection Solutions With Minimal Snapback and Reduced Overshoot Voltage

An electrostatic discharge (ESD) protection structure constructed by the stacking of multiple anode gate-cathode gate directly connected silicon-controlled rectifiers (DCSCRs), fabricated in a 0.18-μm CMOS technology is reported in this letter. Two embedded diodes in the DCSCR dictate the turn-ON mechanism and hence give rise to a trigger voltage equal to twice the diode's turn-ON voltage. This approach enables the DCSCR to offer a diode-like transmission line pulsing IV characteristic with a minimal snapback and a SCR-like high-ESD robustness. At 25 °C, DCSCR has an acceptable nanoampere-level leakage current. Besides, it is verified that the DCSCR can significantly reduce overshoot voltage when stressed by very-fast-rising pulses. As such, an ESD clamp constructed by stacking a selected number of DCSCRs can offer a flexible trigger/holding voltage and is suitable for low and medium voltage ESD protection applications.
Attitudes to early rheumatoid arthritis: changing patterns. Results of a survey.

OBJECTIVE
To determine if rheumatologists have changed their views on diagnosis and treatment of early rheumatoid arthritis (RA).


METHODS
Three consecutive questionnaires were sent out to international rheumatologists in 1997, 2000, and 2003. The following aspects of early RA were covered: definition; patient referral time; diagnostic means; follow up intervals; and treatment strategies. All initial participants who responded to at least one of the follow up surveys were included in the analysis.


RESULTS
RA is now defined by a smaller number of affected joints (monarthritis: 9.8% respondents in 1997 v 17.4% in 2003), and shorter symptom duration (<3 months: 65.5% in 1997 v 85.8% in 2003). Early referrals (<6 weeks) increased (8.9% in 1997 v 17.4% in 2003). Serological test for diagnosis was mostly rheumatoid factor (100% in 2003), but anti-CCP was already used by 17.4% in 2003. Follow up of patients with early RA intensified (every 2 weeks: 16.1% in 1997 v 30.4% in 2003; every month: 47.8% in 2003 v 64.3% in 1997). Treatment with disease modifying antirheumatic drugs (DMARDs) mainly comprised methotrexate, sulfasalazine, and antimalarial drugs. Leflunomide was among the two favourite DMARDs of 10.9% in 2003, whereas no biological agent was so. In 2003, 46.7% respondents started treatment with DMARDs if RA was suspected (30.9% in 1997); no one waited for erosions to occur (7.3% in 1997).


CONCLUSION
The data obtained in this study suggest that the concept of diagnosing and treating RA early is accepted by a large proportion of the rheumatological community.
The virtual republic : Australia's culture wars of the 1990s

Introducing the virtual republicPART ONE: ROOTS1 When I hear the word 'culture', I reach for the remote control2 Mapping the Antipodes3 The Libertarian line4 A secret history of Sydney postmodernismPART TWO: AERIALS5 The Demidenko effect6 Political correctness and the perils of the pale penis people7 Postmodernism meets the attack of the killer Darwinists!8 The fall of the magic kingdom9 Fair go, PaulinePART THREE: NOTES
The Six-Port in Modern Society

Modern wireless sensing and communication systems are often based on high bandwidth and high carrier frequencies. In the range beyond 100 GHz, common receiver architectures, like active homodyne or heterodyne receivers, have an issue with the amplification needed for mixing. Also, high bandwidth is a problem for these systems. In this context, the six-port receiver is a good alternative, just as well as for lowvolume markets. The six-port concept is based on the additive superposition of the two RF input signals using four different relative phases leading to constructive or destructive interaction. The resulting signals are directly downconverted to baseband by diode circuits operated in detector or mixing mode. The complexvalued information can be easily reconstructed from the four baseband voltages. Historic evolution leads from the reflectometer approach for an alternative vector network analyzer to receivers for sensing and communications. A recent topic is the technology gap in automotive workshops for adjusting the long-range radar sensor of a car. Here, the six-port concept as alignment tool is a good choice, because of its excellent phase resolution. Currently, the integration of the six-port receiver on a MMIC for frequencies beyond 100 GHz is the focus of current work and will be intensified in the future. Will the six-port concept replace common active homodyne and heterodyne receivers? No, but it is a serious alternative for millimeter-wave frequencies and ultrahigh-bandwidth applications in wireless sensing and communication systems. This modern concept can tap new markets for both wireless sensors and sensor networks.
Grain-size effects on properties of some ferroelectric ceramics

Hot-pressed ceramics of the lead titanate zirconate system with different grain sizes were prepared and some of their electrical properties measured. The values of the dielectric and piezoelectric properties were analysed together with information on barium titanate ceramics already published in the literature. Many similarities were found between both systems. There are two main contributions to the properties : the single-crystal single-domain intrinsic effect and the contribution of the wall motion. These two effects are active at different values of grain sizes and the 90" wall thickness, compared with the grain size, is the 'key' to study their influence. The intrinsic effect is analysed considering the grains as monodomains. A model is developed which proposes that each grain has a different transition temperature r.. The r. values are taken as following a Gaussian distribution and the behaviour of the dielectric constant against temperature is computed and checked with experimental results. Measurements show that when the grain size decreases, r. increases, the maximum of the dielectric constant decreases, the peak widens and room temperature values of the dielectric constant become lower. All these results can be explained qualitatively with our model : a connection between findings and the idea of diffuse phase transitions is outlined.
Electric field computation of composite line insulators up to 1200 kV AC

Satisfactory operation of composite insulators is intimately related to the surface electric field (stress) distribution. This paper presents results of calculation of the electric field distribution for composite insulators up to 1200 kV, using a 3D software package based on the Boundary Element Method. The impact of corona and grading rings, single and bundled conductors, insulator orientation (dead-end and suspension), single and double units, and surface condition (dry and wet) on the electric field distribution has been analyzed. For UHV systems (higher than 750 kV ac) the use of dual insulators with individual corona rings at the line and ground end and a common grading ring at the line end is beneficial. The existence of optimal dimensions of corona and grading arrangement has been illustrated on a 1000 kV insulator string. It was found that the dead end insulators experience higher electric stress when compared to their suspension counterparts and this difference gets more prominent as the system voltage increases.
Is Qualitative Research Second Class Science? A Quantitative Longitudinal Examination of Qualitative Research in Medical Journals

BACKGROUND
Qualitative research appears to be gaining acceptability in medical journals. Yet, little is actually known about the proportion of qualitative research and factors affecting its publication. This study describes the proportion of qualitative research over a 10 year period and correlates associated with its publication.


DESIGN
A quantitative longitudinal examination of the proportion of original qualitative research in 67 journals of general medicine during a 10 year period (1998-2007). The proportion of qualitative research was determined by dividing original qualitative studies published (numerator) by all original research articles published (denominator). We used a generalized estimating equations approach to assess the longitudinal association between the proportion of qualitative studies and independent variables (i.e. journals' country of publication and impact factor; editorial/methodological papers discussing qualitative research; and specific journal guidelines pertaining to qualitative research).


FINDINGS
A 2.9% absolute increase and 3.4-fold relative increase in qualitative research publications occurred over a 10 year period (1.2% in 1998 vs. 4.1% in 2007). The proportion of original qualitative research was independently and significantly associated with the publication of editorial/methodological papers in the journal (b = 3.688, P = 0.012); and with qualitative research specifically mentioned in guidelines for authors (b = 6.847, P<0.001). Additionally, a higher proportion of qualitative research was associated only with journals published in the UK in comparison to other countries, yet with borderline statistical significance (b = 1.776, P = 0.075). The journals' impact factor was not associated with the publication of qualitative research.


CONCLUSIONS
Despite an increase in the proportion of qualitative research in medical journals over a 10 year period, the proportion remains low. Journals' policies pertaining to qualitative research, as expressed by the appearance of specific guidelines and editorials/methodological papers on the subject, are independently associated with the publication of original qualitative research; irrespective of the journals' impact factor.
Object Detection Using Strongly-Supervised Deformable Part Models

Deformable part-based models [1, 2] achieve state-of-the-art performance for object detection, but rely on heuristic initialization during training due to the optimization of non-convex cost function. This paper investigates limitations of such an initialization and extends earlier methods using additional supervision. We explore strong supervision in terms of annotated object parts and use it to (i) improve model initialization, (ii) optimize model structure, and (iii) handle partial occlusions. Our method is able to deal with sub-optimal and incomplete annotations of object parts and is shown to benefit from semi-supervised learning setups where part-level annotation is provided for a fraction of positive examples only. Experimental results are reported for the detection of six animal classes in PASCAL VOC 2007 and 2010 datasets. We demonstrate significant improvements in detection performance compared to the LSVM [1] and the Poselet [3] object detectors.
DBMSs Should Talk Back Too

Natural language user interfaces to database systems have been studied for several decades now. They have mainly focused on parsing and interpreting natural language queries to generate them in a formal database language. We envision the reverse functionality, where the system would be able to take the internal result of that translation, say in SQL form, translate it back into natural language, and show it to the initiator of the query for verification. Likewise, information extraction has received considerable attention in the past ten years or so, identifying structured information in free text so that it may then be stored appropriately and queried. Validation of the records stored with a backward translation into text would again be very powerful. Verification and validation of query and data input of a database system correspond to just one example of the many important applications that would benefit greatly from having mature techniques for translating such database constructs into free-flowing text. The problem appears to be deceivingly simple, as there are no ambiguities or other complications in interpreting internal database elements, so initially a straightforward translation appears adequate. Reality teaches us quite the opposite, however, as the resulting text should be expressive, i.e., accurate in capturing the underlying queries or data, and effective, i.e., allowing fast and unique interpretation of them. Achieving both of these qualities is very difficult and raises several technical challenges that need to be addressed. In this paper, we first expose the reader to several situations and applications that need translation into natural language, thereby, motivating the problem. We then outline, by example, the research problems that need to be solved, separately for data translations and query translations.
Treatment of depression and effect of antidepression treatment on nutritional status in chronic hemodialysis patients.

BACKGROUND
Depression, which is the most common psychological complication in patients with end-stage renal disease (ESRD), has an impact on the clinical outcome and is associated with malnutrition in chronic hemodialysis patients. This study evaluated the effect of antidepression treatment on nutritional status in depressed chronic hemodialysis patients.


METHODS
Sixty-two ESRD patients who underwent dialysis for more than 6 months were interviewed and completed a Beck Depression Inventory assessment. Thirty-four patients who had scores greater than 18 on the Beck Depression Inventory score and met Diagnostic and Statistical Manual of Mental Disorders, 4th Edition criteria for major depressive disorder were selected to receive paroxetine 10 mg/day and psychotherapy for 8 weeks. The remaining 28 patients were assigned to the control group. Change in the severity of depressive symptoms was ascertained by administering the Hamilton Depression Rating Scale. Nutritional status was evaluated by normalized protein catabolic rate, serum albumin and blood urea nitrogen level.


RESULTS
All patients successfully completed 8 weeks of antidepression treatment. Antidepression treatment decreased the severity of depressive symptoms (Hamilton Depression Rating Scale score: 16.6 +/- 7.0 versus 15.1 +/- 6.6, P < 0.01) and increased normalized protein catabolic rate (1.04 +/- 0.24 versus 1.17 +/- 0.29 g/kg/day, P < 0.05), serum albumin (37.3 +/- 2.0 versus 38.7 +/- 3.2 g/l, P < 0.005), and prehemodialysis blood urea nitrogen level (24.3 +/- 5.6 versus 30.2 +/- 7.9 mmol/L, P < 0.001). In the control group, no change was noted during the study period.


CONCLUSION
This study suggests that antidepressant medication with supportive psychotherapy can successfully treat depression and improve nutritional status in chronic hemodialysis patients with depression.
Adjuvant radiotherapy and survival outcomes in early-stage endometrial cancer: a multi-institutional analysis of 608 women.

OBJECTIVE
The role of post-operative radiotherapy (RT) in women with early-stage, low to intermediate risk cancer of the uterine corpus remains controversial. The primary objective of this analysis was to evaluate the survival outcomes of women with early-stage endometrial cancer treated with surgery alone or surgery followed by RT.


METHODS
Data from two institutions were collected from 1990 to 2003. The 608 eligible women had FIGO stage IA to IIA endometrial cancer and underwent primary surgery +/-RT. Univariate and multivariate analyses of pertinent variables were performed for the end points of disease-free survival (DFS) and overall survival (OS).


RESULTS
The median age for all women was 64 years. RT was delivered to 133 women (22%). Unfavorable histologic grade (P < 0.0001) and stage (P < 0.0001) were significantly more prevalent in the adjuvant RT group. At a median follow-up of 5.2 years, 26 pelvic (11 vaginal) and 16 distant failures occurred along with 110 deaths (with no significant differences between women undergoing surgery alone or followed by RT). Adjuvant RT, younger age, and lower stage predicted for improved DFS and OS on multivariate analysis. Stratified analysis revealed that adjuvant RT conferred a survival benefit in women with stage IC or IIA disease.


CONCLUSIONS
Adjuvant RT was associated with improved disease-free and overall survival in women with higher risk disease. Despite significantly worse disease characteristics among women in the adjuvant RT group, the analyzed end points were equivalent among the two groups. These findings suggest that adjuvant radiotherapy has a significant benefit in reducing mortality and disease progression in early-stage carcinoma of the uterine corpus.