LLukas22/scidocs huggingface dataset:
A New track for unifying general relativity with quantum field theories

In the perspective of unifying quantum field theories with general relativity,the equations of the internal dynamics of the vacuum and mass structures of a set of interacting particles are proved to be in one-to-one correspondence with the equations of general relativity. This leads us to envisage a high value for the cosmological constant,as expected theoretically.
Design of Fuzzy PID controller for Brushless DC motor

Brushless DC (BLDC) motors are widely used for many industrial applications because of their high efficiency, high torque and low volume. This paper proposed a improved Fuzzy PID controller to control speed of Brushless DC motor. The proposed controller is called proportional-integral-derivative (PID) controller and Fuzzy proportional-integral-derivative controller. This paper provides an overview of performance conventional PID controller and Fuzzy PID controller. It is difficult to tune the parameters and get satisfied control characteristics by using normal conventional PID controller. As the Fuzzy has the ability to satisfied control characteristics and it is easy for computing, In order to control the BLDC motor, a Fuzzy PID controller is designed as the controller of the BLDC motor. The experimental results verify that a Fuzzy PID controller has better control performance than the conventional PID controller. The modeling, control and simulation of the BLDC motor have been done using the software package MATLAB/SIMULINK.
An expert-supported monitoring system for patients with chronic obstructive pulmonary disease in general practice: results of a cluster randomised controlled trial.

OBJECTIVE
To investigate the long-term effectiveness of a general practice monitoring system with respiratory expert recommendations for general practitioners' management of patients with chronic obstructive pulmonary disease (COPD), compared with usual care.


DESIGN, SETTINGS AND PARTICIPANTS
A multicentre randomised controlled trial of patients with COPD, clustered by general practices; 200 participants were recruited to maintain at least 75 participants per group for analysis. The trial took place from July 2005 to February 2008 in the south-western region of the Netherlands.


INTERVENTION
Ongoing half-yearly monitoring of COPD patients with respiratory expert recommendations for the GP was compared with usual care.


MAIN OUTCOME MEASURES
Primary outcome - Chronic Respiratory Questionnaire (CRQ) score; secondary outcomes - CRQ domain scores, generic health-related quality of life (Short-Form 12 and EuroQol-5D), breathlessness (Modified Medical Research Council score), exacerbations, and decline in forced expiratory volume in 1 second. A detailed process evaluation was performed along with the trial.


RESULTS
Data from 170 participants were analysed. Based on repeated measurement analyses, the additional gain in CRQ score during follow-up was 0.004 points for monitoring compared with usual care (95% CI, - 0.172 to 0.180). Also, no important differences between monitoring and the usual care group were found for secondary outcomes. Half the monitoring visits resulted in disease management recommendations by a respiratory expert, and 46% of these recommendations were implemented by the GPs. Patient adherence to lifestyle recommendations was low.


CONCLUSION
An expert-supported monitoring system for patients with COPD was not clinically effective. As patients had a pre-existing entry in the monitoring system, the population may be well regulated, with reduced room for improvement.


TRIAL REGISTRATION
www.clinicaltrials.gov NCT00542061.
A Tale of Two Cultures: Bringing Literary Analysis and Computational Linguistics Together

There are cultural barriers to collaborative effort between literary scholars and computational linguists. In this work, we discuss some of these problems in the context of our ongoing research project, an exploration of free indirect discourse in Virginia Woolf’s To The Lighthouse, ultimately arguing that the advantages of taking each field out of its “comfort zone” justifies the inherent difficulties.
A systematic review of the effectiveness of health promotion aimed at improving oral health.

OBJECTIVE
To examine the quality of oral health promotion research evidence and to assess the effectiveness of health promotion, aimed at improving oral health using a systematic and scientifically defensible methodology.


BASIC RESEARCH DESIGN
Systematic review of oral health promotion research evidence using electronic searching, iterative hand-searching, critical appraisal and data synthesis.


CLINICAL SETTING
The settings of the primary research reviewed were clinical, community, schools or other institutions. The participants were children, the elderly, adults and people with handicaps and disabilities.


INTERVENTIONS
Only studies which reported an evaluative component were included. Theoretical and purely descriptive papers were excluded.


MAIN OUTCOME MEASURES
The review examined the evidence of effectiveness of oral health promotion on caries, oral hygiene, oral health related knowledge, attitudes and behaviours.


RESULTS
Very few definitive conclusions about the effectiveness of oral health promotion can be drawn from the currently available evidence. Caries and periodontal disease can be controlled by regular toothbrushing with a fluoride toothpaste but a cost-effective method for reliably promoting such behaviour has not yet been established. Knowledge levels can almost always be improved by oral health promotion initiatives but whether these shifts in knowledge and attitudes can be causally related to changes in behaviour or clinical indices of disease has also not been established.


CONCLUSIONS
Oral health promotion which brings about the use of fluoride is effective for reducing caries. Chairside oral health promotion has been shown to be effective more consistently than other methods of health promotion. Mass media programmes have not been shown to be effective. The quality of oral health promotion evaluation research needs to be improved.
Phase II Trial: Undifferentiated Versus Differentiated Autologous Mesenchymal Stem Cells Transplantation in Egyptian Patients with HCV Induced Liver Cirrhosis

The study was aimed to evaluate the effect of autologous transplantation of BM-derived undifferentiated and differentiated MSCs in cirrhotic patients following chronic hepatitis C virus infection. Twenty-five patients with Child C liver cirrhosis, MELD score >12 were included. They were divided into 2 groups. Group I, the MSCs group (n = 15), this group was subdivided into two subgroups: Ia & Ib (undifferentiated and differentiated respectively). Group II (control group; n = 10) involved patients with cirrhotic liver under conventional supportive treatment. Ninety ml BM was aspirated from the iliac bone for separation of MSCs. Surface expression of CD271, CD29 and CD34 were analyzed using flowcytometry. Hepatogenesis was assessed by immunohistochemical expression of OV6, AFP and albumin. Finally approximately 1 million MSCs/Kg were suspended in saline and were placed in blood bag and injected slowly intravenously over 15 min at a rate of 5 drops/min in one session. Follow up of patients at 3 and 6 months postinfusion revealed partial improvement of liver function tests with elevation of prothrombin concentration and serum albumin levels, decline of elevated bilirubin and MELD score in MSCs group. Statistical comparisons between the two subgroups (group Ia & Ib) did not merit any significant difference regarding clinical and laboratory findings. In conclusion: Bone marrow MSCs transplantation either undifferentiated or differentiated can be used as a potential treatment for liver cirrhosis.
Efficacy and tolerability of telmisartan plus amlodipine in added-risk hypertensive patients.

OBJECTIVES
Added-risk hypertensive patients with co-morbidities such as diabetes and metabolic syndrome often require two or more antihypertensives to achieve blood pressure (BP) targets. The aim of this sub-analysis was to determine the efficacy and safety of telmisartan 40 or 80 mg plus amlodipine 5 or 10 mg in patients with hypertension, stratified according to certain criteria such as type 2 diabetes mellitus and metabolic syndrome.


METHODS
Patients were treated for 8 weeks with telmisartan 20-80 mg plus amlodipine 2.5-10 mg. This post-hoc analysis included patients treated with higher doses, and stratified according to a number of sub-populations (age, race, diabetes, obesity, metabolic syndrome, elevated baseline systolic BP (SBP), renal impairment).


RESULTS
Eight weeks' treatment with telmisartan plus amlodipine combinations provided consistent reductions in mean SBP/diastolic BP (DBP) across the different sub-populations, similar to the overall population. SBP/DBP reductions ranged from -13.5 to -34.7/-12.6 to -26.1 mmHg and BP goal rates (<140/90 mmHg) ranged from 29.8-100% for the four key dose combinations of telmisartan plus amlodipine. For the highest dose combination of telmisartan 80 mg plus amlodipine 10 mg, SBP/DBP reduction ranged from -19.1 to -34.7/-16.4 to -22.8 mmHg and goal attainment rate from 66.7% to 87.0%. Across the sub-populations, high SBP and DBP response rates were seen with combination treatment (83.3-97.7% and 75.0-95.7%, respectively, with telmisartan 80 mg plus amlodipine 10 mg). The combination was safe and well tolerated across all sub-populations and the incidence of peripheral oedema with telmisartan 40-80 mg plus amlodipine 10 mg was generally lower than with A10 monotherapy.


CONCLUSIONS
Despite small patient numbers in some sub-populations and the post-hoc nature of the analysis, this does show that the combination of telmisartan plus amlodipine provides an effective, safe and well-tolerated antihypertensive treatment for added-risk hypertensive patients.
Pincer-Search: An Efficient Algorithm for Discovering the Maximum Frequent Set

Discovering frequent itemsets is a key problem in important data mining applications, such as the discovery of association rules, strong rules, episodes, and minimal keys. Typical algorithms for solving this problem operate in a bottom-up, breadth-first search direction. The computation starts from frequent 1-itemsets (the minimum length frequent itemsets) and continues until all maximal (length) frequent itemsets are found. During the execution, every frequent itemset is explicitly considered. Such algorithms perform well when all maximal frequent itemsets are short. However, performance drastically decreases when some of the maximal frequent itemsets are relatively long. We present a new algorithm which combines both the bottom-up and the top-down searches. The primary search direction is still bottom-up, but a restricted search is also conducted in the top-down direction. This search is used only for maintaining and updating a new data structure, the maximum frequent candidate set. It is used to prune early candidates that would normally encountered in the bottom-up search. A very important characteristic of the algorithm is that it does not require explicite examination of every frequent itemset. Therefore the algorithm performs well even when some maximal frequent itemsets are long. As its output, the algorithm produces the maximum frequent set, i.e., the set containing all maximal frequent itemsets, thus specifying immediately all frequent itemsets. We evaluate the performance of the algorithm using well-known synthetic benchmark databases and real-life census and ∗Applied Research, Telcordia Technologies, Inc., 445 South Street, Morristown, NJ 07960 +1 973 829 4740, tlin@research.telcordia.com. †Department of Computer Science, Courant Institute of Mathematical Sciences, New York University, 251 Mercer St., New York, NY 100121185, +1 212 998 3101, kedem@cs.nyu.edu.
Selected major risk factors and global and regional burden of disease

BACKGROUND
Reliable and comparable analysis of risks to health is key for preventing disease and injury. Causal attribution of morbidity and mortality to risk factors has traditionally been in the context of individual risk factors, often in a limited number of settings, restricting comparability. Our aim was to estimate the contributions of selected major risk factors to global and regional burden of disease in a unified framework.


METHODS
For 26 selected risk factors, expert working groups undertook a comprehensive review of published work and other sources--eg, government reports and international databases--to obtain data on the prevalence of risk factor exposure and hazard size for 14 epidemiological regions of the world. Population attributable fractions were estimated by applying the potential impact fraction relation, and applied to the mortality and burden of disease estimates from the global burden of disease (GBD) database.


FINDINGS
Childhood and maternal underweight (138 million disability adjusted life years [DALY], 9.5%), unsafe sex (92 million DALY, 6.3%), high blood pressure (64 million DALY, 4.4%), tobacco (59 million DALY, 4.1%), and alcohol (58 million DALY, 4.0%) were the leading causes of global burden of disease. In the poorest regions of the world, childhood and maternal underweight, unsafe sex, unsafe water, sanitation, and hygiene, indoor smoke from solid fuels, and various micronutrient deficiencies were major contributors to loss of healthy life. In both developing and developed regions, alcohol, tobacco, high blood pressure, and high cholesterol were major causes of disease burden.


INTERPRETATION
Substantial proportions of global disease burden are attributable to these major risks, to an extent greater than previously estimated. Developing countries suffer most or all of the burden due to many of the leading risks. Strategies that target these known risks can provide substantial and underestimated public-health gains.
Evaluation of treatment of zygomatic bone and zygomatic arch fractures: a retrospective study of 10 years.

OBJECTIVE
The aim of this study was to investigate the treatment of zygomatic bone and zygomatic arch fractures without other facial fractures.


PATIENTS AND METHODS
A 10 year (2000-2010) retrospective study involving 310 patients admitted and treated for zygomatic bone and zygomatic arch fractures at the department of oral and maxillofacial surgery was done. The data collection protocol included: age, gender, site, type of fracture. Other data presented included clinical diagnosis, radiographic examination findings as well as preoperative and postoperative imaging for evaluation of the fracture. Descriptive statistics was performed with SPSS version 16.


RESULTS
The ages of the patients ranged from 10 to 76 years old, mean age was 32.33 years. 237(80.6%) of the patients were males and 73 (19.4%) were females (Table 1). According to the site of fracture, the patients were divided into three groups: group A, with zygomatic bone fracture, group B with zygomatic arch fracture and group C with co-existing zygomatic bone and zygomatic arch fracture. Regarding the site of fracture 57.7% of the patients had fractures of the zygomatic bone, 13.8% had fractures of the zygomatic arch and 28.4% had fractures of both zygomatic bone and zygomatic arch. [Table: see text] The treatment of both fractures was: closed reduction for isolated zygomatic arch fractures; open reduction and internal rigid fixation through a coronal incision was performed in comminuted arch fractures and displaced fractures.


CONCLUSION
In this study, the majority of the patients were young adult men; road traffic accidents were the leading cause of fractures. According to the site of fracture, various modalities of treatment were used and all the patients achieved satisfactory results without any complications after operation.
Feasibility study of stereotactic body radiotherapy for peripheral lung tumors with a maximum dose of 100 Gy in five fractions and a heterogeneous dose distribution in the planning target volume

We evaluated toxicity and outcomes for patients with peripheral lung tumors treated with stereotactic body radiation therapy (SBRT) in a dose-escalation and dose-convergence study. A total of 15 patients were enrolled. SBRT was performed with 60 Gy in 5 fractions (fr.) prescribed to the 60% isodose line of maximum dose, which was 100 Gy in 5 fr., covering the planning target volume (PTV) surface (60 Gy/5 fr. - (60%-isodose)) using dynamic conformal multiple arc therapy (DCMAT). The primary endpoint was radiation pneumonitis (RP) ≥ Grade 2 within 6 months. Toxicities were graded according to the Common Terminology Criteria for Adverse Events, version 4.0. Using dose-volumetric analysis, the trial regimen of 60 Gy/5 fr. - (60%-isodose) was compared with our institutional conventional regimen of 50 Gy/5 fr. - (80%-isodose). The enrolled consecutive patients had either a solitary peripheral tumor or two ipsilateral tumors. The median follow-up duration was 22.0 (12.0-27.0) months. After 6 months post-SBRT, the respective number of RP Grade 0, 1 and 2 cases was 5, 9 and 1. In the Grade 2 RP patient, the image showed an organizing pneumonia pattern at 6.0 months post-SBRT. No other toxicity was found. At last follow-up, there was no evidence of recurrence of the treated tumors. The target volumes of 60 Gy/ 5 fr. - (60%-isodose) were irradiated with a significantly higher dose than those of 50 Gy/5 fr. - (80%-isodose), while the former dosimetric parameters of normal lung were almost equivalent to the latter. SBRT with 60 Gy/5 fr. - (60%-isodose) using DCMAT allowed the delivery of very high and convergent doses to peripheral lung tumors with feasibility in the acute and subacute phases. Further follow-up is required to assess for late toxicity.
Using a Liquid Democracy Tool for End-user Involvement in Continuous RE

REFSQ 2017: Joint Proceedings of 23rd International Working Conference on Requirements Engineering: Foundation for Software Quality, Essen, Germany, February 27, 2017
Monitoring during and after antiviral therapy for hepatitis B.

UNLABELLED
Recent studies suggest that long-term suppression of viral replication is critical to reducing the complications of chronic hepatitis B virus (HBV) infection. Monitoring for continued virological response during and after treatment is essential because current treatment options have limited success in achieving durable endpoints, and antiviral resistance may emerge during long-term therapy. Methods of monitoring treatment response include tests for serum aminotransferase levels, HBV DNA level, hepatitis B e antigen (HBeAg) and antibody (anti-HBe), hepatitis B surface antigen (HBsAg) or antibody (anti-HBs), and liver histology. Virological suppression and loss of HBeAg or HBsAg with or without seroconversion play a prominent role in decision-making regarding the success and duration of antiviral therapy. Guidelines recommend that testing for serum markers be repeated every 12-24 weeks during antiviral therapy and every 6-12 months afterward. Recent data also suggest that serum HBV DNA levels should be assessed at weeks 12 and 24 of therapy, because early viral response may predict the likelihood of sustained response and antiviral resistance. The use of serum HBV DNA levels for this purpose requires an assay with a wide range of quantification, such as real-time polymerase chain reaction assays, which have a 7-8 log(10) dynamic range. Newer, investigational methods for monitoring treatment response include quantitative measurement of HBsAg, HBeAg, and intrahepatic covalently closed circular DNA.


CONCLUSIONS
Better methods for defining durable treatment endpoints are needed. Other areas requiring further research include the optimal treatment duration and the establishment of the optimal use of early viral kinetics for decision-making during antiviral therapy.
Occupational kneeling and squatting: development and validation of an assessment method combining measurements and diaries

OBJECTIVES
As knee-straining postures such as kneeling and squatting are known to be risk factors for knee disorders, there is a need for effective exposure assessment at the workplace. Therefore, the aim of this study was to develop a method to capture knee-straining postures for entire work shifts by combining measurement techniques with the information obtained from diaries, and thus avoiding measuring entire work shifts. This approach was applied to various occupational tasks to obtain an overview of typical exposure values in current specific occupations.


METHODS
The analyses were carried out in the field using an ambulatory measuring system (CUELA) to assess posture combined with one-day self-reported occupational diaries describing the durations of various work tasks. In total, 242 work shifts were measured, representing 81 typical tasks from 16 professions. Knee-straining postures were analysed as daily time intervals for five different postures. The accuracy of the method was examined by comparing the results to measurements of entire work shifts.


RESULTS
Unsupported kneeling was the most widely used knee posture in our sample (median 11.4 % per work shift), followed by supported kneeling (3.0 %), sitting on heels (1.1 %), squatting (0.7 %), and crawling (0.0 %). The daily time spent in knee-straining postures varied considerably, both between the individual occupations, within an occupation (e.g. parquet layers: 0.0-88.9 %), and to some extent even within a single task (e.g. preparation work of floor layers (22.0 ± 23.0 %). The applied measuring method for obtaining daily exposure to the knee has been proven valid and efficient randomly compared with whole-shift measurements (p = 0.27).


CONCLUSIONS
The daily degree of postural exposure to the knee showed a huge variation within the analysed job categories and seemed to be dependent on the particular tasks performed. The results of this study may help to develop an exposure matrix with respect to occupational knee-straining postures. The tested combination of task-based measurement and diary information may be a promising option for providing a cost-effective assessment tool.