LLukas22/scidocs huggingface dataset:
Use of antithrombotic medications among elderly ischemic stroke patients.

BACKGROUND
The use of antithrombotic medications after ischemic stroke is recommended for deep vein thrombosis prophylaxis and secondary stroke prevention. We assessed the rate of receipt of these therapies among eligible ischemic stroke patients age ≥65 years and determined the effects of age and other patient characteristics on treatment.


METHODS AND RESULTS
The analysis included Medicare fee-for-service beneficiaries discharged with ischemic stroke (ICD 433.x1, 434.x1, 436) randomly selected for inclusion in the Medicare Health Care Quality Improvement Program's National Stroke Project 1998 to 1999, 2000 to 2001. Patients discharged from nonacute facilities, transferred, or terminally ill were excluded. Receipt of in-hospital pharmacological deep vein thrombosis prophylaxis, antiplatelet medication, anticoagulants for atrial fibrillation, and antithrombotic medications at discharge were assessed in eligible patients, stratified by age (65 to 74, 75 to 84, and 85+ years). Descriptive models identified characteristics associated with treatment. Among 31 554 patients, 14.9% of those eligible received pharmacological deep vein thrombosis prophylaxis, 83.9% antiplatelet drugs, 82.8% anticoagulants for atrial fibrillation, and 74.2% were discharged on an antithrombotic medication. Rates of treatment decreased with age and were lowest for patients ages 85 years or older. Admission from a skilled nursing facility and functional dependence were associated with lower treatment rates.


CONCLUSIONS
There was substantial underutilization of antithrombotic therapies among elderly ischemic stroke patients, particularly among the very elderly, those admitted from skilled nursing facilities, and patients with functional dependence. The reasons for low use of antithrombotic therapies, including the apparent underutilization of deep vein thrombosis prophylaxis in otherwise eligible patients, require further investigation.
On the Systemogenesis of Activity

All sciences, and indeed not just the sciences but any intellectual effort, purpose to understand the interrelations of phenomena existing at the different stages of our hierarchical ladder in order to discover the connection between beauty and history, between history and human psychology, between psychology and the workings of the brain … and so on, both upward and downward.
Fluidic Thrust Vectoring of Low Observable Aircraft ( 13 / 39 ) 1 FLUIDIC THRUST VECTORING OF LOW OBSERVABLE AIRCRAFT

The work presented in this paper deals with the development of a coflow fluidic thrust vectoring system for use on a low observable unmanned air vehicle operating in the subsonic flight regime. Two approximately 1/10 scale fluidic thrust vectoring demonstrator rigs were designed and built in order to investigate the effect of various geometric variables on thrust vectoring effectiveness. These included secondary gap height, dh, and Coanda surface diameter, ∅. Load measurements were obtained using a six component overhead balance. The thrust vector force, Fz,tv, was made non-dimensional using the thrust force of the nonvectored primary jet, Fx, to give a thrust vector coefficient, Cz. Tests were carried out over the mass flow ratio range 0 m s/mp < 0.13 which corresponded to a momentum flow ratio range of 0 M s/Mp < 0.4. A computational investigation for 2D flow was also undertaken primarily to aid in the design of the experimental demonstrator rigs and smoke flow visualisation techniques were used to further investigate the flow characteristics of a non-vectored and a vectored primary jet. The investigation shows that both the experimental and computational results obtained follow a similar trend line. A ‘dead zone’ appears at low mass flow ratios in which no control can be achieved. There then follows a control region in which continuous thrust vector control can be achieved followed by a hypothetical saturation region. The secondary jet blowing rate, the Coanda surface diameter and the primary nozzle to secondary nozzle height ratio are seen to determine whether effective and efficient fluidic thrust vectoring can be achieved.
Age , gender and income : do they really moderate online shopping behaviour ?

Purpose – The objective of this paper is to analyse whether individuals’ socioeconomic characteristics – age, gender and income – influence their online shopping behaviour. The individuals analysed are experienced e-shoppers i.e. individuals who often make purchases on the internet. Design/methodology/approach – The technology acceptance model was broadened to include previous use of the internet and perceived self-efficacy. The perceptions and behaviour of e-shoppers are based on their own experiences. The information obtained has been tested using causal and multi-sample analyses. Findings – The results show that socioeconomic variables moderate neither the influence of previous use of the internet nor the perceptions of e-commerce; in short, they do not condition the behaviour of the experienced e-shopper. Practical implications – The results obtained help to determine that once individuals attain the status of experienced e-shoppers their behaviour is similar, independently of their socioeconomic characteristics. The internet has become a marketplace suitable for all ages and incomes and both genders, and thus the prejudices linked to the advisability of selling certain products should be revised. Originality/value – Previous research related to the socioeconomic variables affecting e-commerce has been aimed at forecasting who is likely to make an initial online purchase. In contrast to the majority of existing studies, it is considered that the current development of the online environment should lead to analysis of a new kind of e-shopper (experienced purchaser), whose behaviour differs from that studied at the outset of this research field. The experience acquired with online shopping nullifies the importance of socioeconomic characteristics.
Comparative effectiveness of white blood cell growth factors on neutropenia, infection, and survival in older people with non-Hodgkin's lymphoma treated with chemotherapy.

OBJECTIVES
To determine the effect of colony-stimulating factor (CSF) on incidence of febrile neutropenia, infection, and survival in older people with non-Hodgkin's lymphoma (NHL) treated with chemotherapy.


DESIGN
Retrospective cohort study.


SETTING
The Surveillance, Epidemiology, and End Results-Medicare database.


PARTICIPANTS
Thirteen thousand two hundred twenty-three people diagnosed with NHL at age 65 and older (mean age 74.9, range 65-102) in 1992 to 2002 who received chemotherapy within 12 months of diagnosis.


MEASUREMENTS
Primary prophylaxis was defined as CSF administered at the start of chemotherapy before febrile neutropenia or infection; secondary prophylaxis was defined as CSF use after febrile neutropenia or infection.


RESULTS
Participants with five to nine administrations of primary prophylactic CSF had a 42% lower risk of febrile neutropenia (odds ratio (OR)=0.58, 95% confidence interval (CI)=0.41-0.83), and participants with 10 or more administrations had a 48% lower risk (OR=0.52, 95% CI=0.36-0.76) after adjusting for age, stage, histology, and comorbidity. Results did not differ significantly after adjusting for propensity score of receiving CSF. There was no significant association between primary prophylactic CSF and overall survival, but secondary prophylactic CSF was significantly associated with better survival. Four to 10 administrations of secondary prophylactic CSF was associated with 9% lower mortality risk (hazard ratio (HR)=0.91, 95% CI=0.84-0.99), 11 to 23 administrations was associated with 23% lower mortality risk (HR=0.77, 95% CI=0.71-0.84) and 24 or more administrations was associated with 13% lower mortality risk (HR=0.87, 95% CI+0.79-0.95) than in participants not receiving CSF after neutropenia or infection.


CONCLUSION
Primary prophylactic CSF was observed to be effective in reducing the incidence of neutropenia and infection. These findings substantiate the clinical guidelines for recommending prophylactic CSF in older people with NHL receiving chemotherapy.
Predictive Saliency Maps for Surveillance Videos

When viewing video sequences, the human visual system (HVS) tends to focus on the active objects. These are perceived as the most salient regions in the scene. Additionally, human observers tend to predict the future positions of moving objects in a dynamic scene and to direct their gaze to these positions. In this paper we propose a saliency detection model that accounts for the motion in the sequence and predicts the positions of the salient objects in future frames. This is a novel technique for attention models that we call Predictive Saliency Map (PSM). PSM improves the consistency of the estimated saliency maps for video sequences. PSM uses both static information provided by static saliency maps (SSM) and motion vectors to predict future salient regions in the next frame. In this paper we focus only on surveillance videos therefore, in addition to low-level features such as intensity, color and orientation we consider high-level features such as faces as salient regions that attract naturally viewers attention. Saliency maps computed based on these static features are combined with motion saliency maps to account for saliency created by the activity in the scene. The predicted saliency map is computed using previous saliency maps and motion information. The PSMs are compared with the experimentally obtained gaze maps and saliency maps obtained using approaches from the literature. The experimental results show that our enhanced model yields higher ability to predict eye fixations in surveillance videos.
Queensland Economic Review, January 2011

Trend employment in Queensland rose 5,700 persons (0.2%) in December 2010, to be 78,000 persons (3.4%) higher over the year.
TRANSLATION AND VALIDATION OF THE BRAZILIAN PORTUGUESE VERSION OF THE GASTROINTESTINAL SYMPTOM RATING SCALE (GSRS) QUESTIONNAIRE.

BACKGROUND
- Bowel function is a widely evaluated parameter in interventional and longitudinal studies since it is associated with good maintenance of health. The evaluation of intestinal function has been performed by many questionnaires, however, there are few options validated in Brazilian Portuguese.


OBJECTIVE
- The aim of this work was to translate and validate into Brazilian Portuguese the Gastrointestinal Symptom Rating Scale (GSRS) questionnaire.


METHODS
- Translation and cultural adaptation were performed according to a previously established methodology followed by reliability calculations.


RESULTS
- The final translated GSRS questionnaire showed an adequate value of overall reliability of Cronbach's alpha of 0.83, and its domains were classified from acceptable to adequate. The overall test-retest reliability by intraclass correlation coefficient (ICC) was 0.84, considered excellent.


CONCLUSION
- The GSRS was translated and validated into Brazilian Portuguese, with appropriate internal consistency and reliability and is available to be used in assessments of bowel function.
The biomechanics of running.

This review article summarizes the current literature regarding the analysis of running gait. It is compared to walking and sprinting. The current state of knowledge is presented as it fits in the context of the history of analysis of movement. The characteristics of the gait cycle and its relationship to potential and kinetic energy interactions are reviewed. The timing of electromyographic activity is provided. Kinematic and kinetic data (including center of pressure measurements, raw force plate data, joint moments, and joint powers) and the impact of changes in velocity on these findings is presented. The status of shoewear literature, alterations in movement strategies, the role of biarticular muscles, and the springlike function of tendons are addressed. This type of information can provide insight into injury mechanisms and training strategies. Copyright 1998 Elsevier Science B.V.
An Unusual Cause of Chest Pain in a Young Healthy Female.

BACKGROUND
Infection of the sternoclavicular joint is an uncommon disease that is usually seen in patients with underlying risk factors such as prior trauma, intravenous drug use, or diabetes mellitus. The true pathophysiology remains unknown, but underlying bacteremia has been found in a number of cases. Without proper diagnosis and treatment, severe complications such as mediastinitis, sepsis, or death can occur.


CASE REPORT
This is a case of spontaneous stenoclavicular septic arthritis in an otherwise healthy female. The patient's lack of risk factors and minimal examination findings highlight the unusual nature of the case, as well as the challenges it presents in making an early diagnosis. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS CONDITION?: Emergency physicians should consider sternoclavicular joint infections in patients who present to the emergency department with chest pain, even in patients without risk factors. They should especially consider the diagnosis in patients with suspected musculoskeletal etiologies or in those with return visits for chest pain. Although most patients do well with treatment, the infection can be life threatening without appropriate interventions.
Gender-related differences of diabetic patients undergoing percutaneous coronary intervention with drug-eluting stents: a real-life multicenter experience.

BACKGROUND
Gender-based differences in diabetic patients are understudied in the field of percutaneous coronary intervention (PCI) with drug-eluting stents.


METHODS
Data were obtained from a multicenter registry of 2420 consecutive patients with diabetes mellitus (DM) who underwent PCI with paclitaxel- or sirolimus-eluting stents between 2003 and 2009. Among them, 679 (28.1%) women were compared to 1741 (71.9%) men in terms of clinical aspects and major adverse cardiac events (MACE), including all-cause death, myocardial infarction (MI) and target lesion revascularization (TLR). Target vessel revascularization (TVR) and any revascularization were also reported.


RESULTS
Women were less numerous, older, used more insulin and showed more tortuous coronary arteries, while men were more frequently smokers and received larger stents. At the median follow-up of 24.3 months (interquartile range 12.3-39.7), MACE, TVR and any revascularization did not significantly differ between females and males (19.9% vs 18.7%, 12.2% vs 13.4%, 14.1% vs 15.1%, respectively). At multivariable analysis of the overall cohort, female gender was not a predictor of MACE (hazard ratio [HR] 1.02, 95% confidence interval [CI] 0.92-2.36, p=0.11), death (HR 1.04, 95% CI 0.84-1.24, p=0.86), MI (HR 1.48, 95% CI 0.92-2.36, p=0.11), and TLR (HR 1.14, 95% CI 0.85-1.52, p=0.38).


CONCLUSION
In this registry of diabetic patients treated by drug-eluting stents, women were less represented, older and needed more insulin compared to men who, on the other hand, received larger stents. Gender-related outcomes were similar and female sex did not predict MACE.
Differentially Fed Planar Aperture Antenna With High Gain and Wide Bandwidth for Millimeter-Wave Application

This paper presents a novel planar aperture antenna with differential feeding. Compared with conventional high-gain aperture antennas, such as horn and reflector antennas, it maintains a high gain and wide bandwidth, but has a much lower profile with only one quarter-wavelength height. Since the height (λg/4) at millimeter-wave (mmWave) band is as low as the most of the commercially available laminates, planar aperture antennas with high gain and wide bandwidth can be realized at mmWave band using the proposed structure. A prototype working at 60 GHz band was designed and fabricated on a single layer laminate using standard printed circuit board (PCB) technology. A differential feeding network based on E-plane tee was also designed to feed the prototype for the measurement purposes. Experiment results show that the prototype achieves a -15-dB impedance bandwidth from 56.2 to 69.7 GHz (21.5%). The peak gain at broadside is 15.3 dBi at 60 GHz. The 3-dB gain bandwidth is from 54.0 to 67.5 GHz (22.2%). Within the operating bandwidth, the radiation pattern is stable with a low cross-polarization level below -24 dB, and is symmetrical about both the E- and H-planes.
Contemporary Cinematic Work from Finland: the Non-place of Cinema and Identity

The article discusses the identity-crisis that has taken place in the institution of cinema during the last years. The changes (in aesthetics, economics and the sociological conditions) are related ...
Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium.

BACKGROUND & AIMS
We previously established long-term culture conditions under which single crypts or stem cells derived from mouse small intestine expand over long periods. The expanding crypts undergo multiple crypt fission events, simultaneously generating villus-like epithelial domains that contain all differentiated types of cells. We have adapted the culture conditions to grow similar epithelial organoids from mouse colon and human small intestine and colon.


METHODS
Based on the mouse small intestinal culture system, we optimized the mouse and human colon culture systems.


RESULTS
Addition of Wnt3A to the combination of growth factors applied to mouse colon crypts allowed them to expand indefinitely. Addition of nicotinamide, along with a small molecule inhibitor of Alk and an inhibitor of p38, were required for long-term culture of human small intestine and colon tissues. The culture system also allowed growth of mouse Apc-deficient adenomas, human colorectal cancer cells, and human metaplastic epithelia from regions of Barrett's esophagus.


CONCLUSIONS
We developed a technology that can be used to study infected, inflammatory, or neoplastic tissues from the human gastrointestinal tract. These tools might have applications in regenerative biology through ex vivo expansion of the intestinal epithelia. Studies of these cultures indicate that there is no inherent restriction in the replicative potential of adult stem cells (or a Hayflick limit) ex vivo.
Successful implementation of user-centered game based learning in higher education: An example from civil engineering

Goal: The use of an online game for learning in higher education aims to make complex theoretical knowledge more approachable. Permanent repetition will lead to a more in-depth learning. Objective: To gain insight into whether and to what extent, online games have the potential to contribute to student learning in higher education. Experimental Setting: The online game was used for the first time during a lecture on Structural Concrete at Master’s level, involving 121 seventh semester students. Methods: Pretest/posttest experimental control group design with questionnaires and an independent online evaluation. Results: The minimum learning result of playing the game was equal to that achieved with traditional methods. A factor called “joy” was introduced, according to Nielsen (2002), which was amazingly high. Conclusion: The experimental findings support the efficacy of game playing. Students enjoyed this kind of e-Learning.
The impact of Xpert(®) MTB/RIF in sparsely populated rural settings.

BACKGROUND
The impact of implementing Xpert(®) MTB/RIF and the choice of instrument placement on patient care in sparsely populated areas with poor access to laboratory and radiology services have not yet been elucidated.


METHODS
Prospective evaluation of three diagnostic approaches in the Central Karoo, South Africa: smear microscopy as the initial diagnostic, with sputum processing at centralised laboratories, and Xpert as the initial diagnostic with instrument placement at facility level or centralised laboratory.


RESULTS
Of 1449 individuals, 196 were diagnosed with TB. The proportion positive on initial testing was respectively 8%, 20% and 8% during the smear microscopy, decentralised Xpert and centralised Xpert periods. The proportion of bacteriologically confirmed cases was respectively 88%, 99% and 91% during the smear microscopy, decentralised Xpert and centralised Xpert periods. The median time to treatment was respectively 11.5 (interquartile range [IQR] 6-24), 1 (IQR 0-2) and 6 days (IQR 2-9) during the smear microscopy, decentralised Xpert and centralised Xpert periods.


CONCLUSION
Introducing Xpert as the initial diagnostic in areas with poor access to TB diagnostics increased the proportion of cases with bacteriological confirmation and reduced time to treatment initiation; however, point-of-care placement may have resulted in fewer people being evaluated for TB.
Methylphenidate Ameliorates Depressive Comorbidity in ADHD Children without any Modification on Differences in Serum Melatonin Concentration between ADHD Subtypes

UNLABELLED
The vast majority of Attention-deficit/hyperactivity disorder (ADHD) patients have other associated pathologies, with depressive symptoms as one of the most prevalent. Among the mediators that may participate in ADHD, melatonin is thought to regulate circadian rhythms, neurological function and stress response. To determine (1) the serum baseline daily variations and nocturnal excretion of melatonin in ADHD subtypes and (2) the effect of chronic administration of methylphenidate, as well as the effects on symptomatology, 136 children with ADHD (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision: DSM-IV-TR criteria) were divided into subgroups using the "Children's Depression Inventory" (CDI). Blood samples were drawn at 20:00 and 09:00 h, and urine was collected between 21:00 and 09:00 h, at inclusion and after 4.61 ± 2.29 months of treatment. Melatonin and its urine metabolite were measured by radioimmunoassay RIA. Factorial analysis was performed using STATA 12.0. Melatonin was higher predominantly in hyperactive-impulsive/conduct disordered children (PHI/CD) of the ADHD subtype, without the influence of comorbid depressive symptoms. Methylphenidate ameliorated this comorbidity without induction of any changes in the serum melatonin profile, but treatment with it was associated with a decrease in 6-s-melatonin excretion in both ADHD subtypes.


CONCLUSIONS
In untreated children, partial homeostatic restoration of disrupted neuroendocrine equilibrium most likely led to an increased serum melatonin in PHI/CD children. A differential cerebral melatonin metabolization after methylphenidate may underlie some of the clinical benefit.