LLukas22/scidocs huggingface dataset:
Structural and Electron Aspects of Nitrogen‐Nitrogen Bond

Introduction Nitrogen, like many other chemical elements, has catenation ability. The variety and multiplicity of molecular structures with nitrogen-nitrogen bond is significantly smaller than for carbon. Such compounds are of particular interest as potential high-energy density materials (HEDM) [1], because they can undergo exothermic reaction Nx → (x/2)N2 releasing 50 kcal/mol or more per one nitrogen atom [2]. However, their practical application is limited by their stability. Known are chain, cyclic as well as cage systems containing nitrogennitrogen bond. The experimental studies have proven that it is possible to obtain ions N3 − to N5 + in laboratory conditions [3÷5] as well as polymer networks [6] but only under high pressure (110 GPa). Based on the crystallographic resources of Cambridge Structural Database (CSD) [7], one can conclude that the largest family of chemical compounds involves systems with two nitrogen atoms connected to each other (approx. 85% of all structures of type Nx, where x ≥ 2). Among these system, the largest group are hydrazo, azo, azoxy and azodioxy compounds and compounds containing nitramine group. The first four groups form oxidation reduction series in relation to each other. Hydrazo functional group contains two nitrogen atoms sp3 connected by σ bond and each of them forms additional chemical bond with hydrogen atom. While two nitrogen atoms of hybridization sp2 each of which has nonbonding electron pair and which are doublebounded to each other form bivalent nitrogen group. The molecules of chemical compounds containing this functional group may exist as two geometric isomers E and Z. Azoxy functional group is formed as a result of formation of chemical bond between oxygen atom and free electron pair of one of azo group nitrogen atoms. Azoxy compounds, called also diazene N-oxides also show geometric isomerism Z and E with the respect to nitrogen-nitrogen bond. If both nitrogen atoms of azo group form chemical bond with oxygen atom (>N2O2), such group is called azodioxy. It is the most oxidized form of nitrogennitrogen bond [8–14]. The different order of connecting oxygen and nitrogen atoms within the group of >N2O2 (N–NO2) can be found in family of compounds called nitramines. Nitramine group forms in these compound four-core π-electron system that may interact with substituents of amide nitrogen atom. The studies of properties of N-N bond and effect of nitramine group on ring aromaticity in family of nitramine phenyl derivatives are also motivated by the desire to explain the mechanism of so called nitramine rearrangement.
Calcitonin gene-related peptide induced migraine attacks in patients with and without familial aggregation of migraine.

Background Calcitonin gene-related peptide provokes migraine attacks in 65% of patients with migraine without aura. Whether aggregation of migraine in first-degree relatives (family load) or a high number of risk-conferring single nucleotide polymorphisms contributes to migraine susceptibility to calcitonin gene-related peptide infusion in migraine patients is unknown. We hypothesized that genetic enrichment plays a role in triggering of migraine and, therefore, migraine without aura patients with high family load would report more migraine attacks after calcitonin gene-related peptide infusion than patients with low family load. Methods We allocated 40 previously genotyped migraine without aura patients to receive intravenous infusion of 1.5 µg/min calcitonin gene-related peptide and recorded migraine attacks including headache characteristics and associated symptoms. Information of familial aggregation was obtained by telephone interview of first-degree relatives using a validated semi-structured questionnaire. Results Calcitonin gene-related peptide infusion induced a migraine-like attack in 75% (12 out of 16) of patients with high family load compared to 52% (12 out of 23) with low family load ( P = 0.150). In addition, we found that the migraine response after calcitonin gene-related peptide was not associated with specific or a high number of risk-conferring single nucleotide polymorphisms of migraine without aura. Conclusion We found no statistical association between familial aggregation of migraine and hypersensitivity to calcitonin gene-related peptide infusion in migraine without aura patients. We also demonstrated that the currently known single nucleotide polymorphisms conferring risk of migraine without aura have no additive effect on calcitonin gene-related peptide induced migraine-like attacks.
Jets in nuclear collisions: status and perspective

Abstract.I review the status and future directions of jet-related measurements in high energy nuclear collisions and their application as a probe of QCD matter.
Osseointegration and clinical success of zirconia dental implants: a systematic review.

PURPOSE
Various ceramic implant systems made of yttria-stabilized tetragonal zirconia polycrystals (Y-TZP) have become commercially available in recent years. A systematic search of the literature was performed to assess the clinical success of dental Y-TZP implants and whether the osseointegration of Y-TZP is comparable to that of titanium, the standard implant material.


MATERIALS AND METHODS
The internet database MEDPILOT was searched cumulatively for the keywords zircon* and dent* and implant as well as for zircon* and osseointegration. The last search was conducted on January 31st, 2007. Subsequently, the reference lists of the relevant publications were searched. Furthermore, a letter was sent to the 5 identified manufacturers of zirconia dental implants to ask for peer-reviewed publications.


RESULTS
Ninety-six articles were found by the search strategy. No controlled clinical studies in humans regarding clinical outcomes or osseointegration could be identified. Clinical data were restricted to case studies and case series. Only 7 animal studies fulfilled the inclusion criteria. Osseointegration was evaluated at 4 weeks to 24 months after placement in different animal models and sites and under different loading conditions. The mean bone-implant contact percentage was above 60% in almost all experimental groups. In studies that used titanium implants as a control, Y-TZP implants were comparable to or even better than titanium implants. Surface modifications may further improve initial bone healing and resistance to removal torque.


CONCLUSIONS
Y-TZP implants may have the potential to become an alternative to titanium implants but cannot currently be recommended for routine clinical use, as no long-term clinical data are available.
Ranking Sentences for Extractive Summarization with Reinforcement Learning

Single document summarization is the task of producing a shorter version of a document while preserving its principal information content. In this paper we conceptualize extractive summarization as a sentence ranking task and propose a novel training algorithm which globally optimizes the ROUGE evaluation metric through a reinforcement learning objective. We use our algorithm to train a neural summarization model on the CNN and DailyMail datasets and demonstrate experimentally that it outperforms state-of-the-art extractive and abstractive systems when evaluated automatically and by humans.1
Toward a more practical unsupervised anomaly detection system

During the last decade, various machine learning and data mining techniques have been applied to Intrusion Detection Systems (IDSs) which have played an important role in defending critical computer systems and networks from cyber attacks. Unsupervised anomaly detection techniques have received a particularly great amount of attention because they enable construction of intrusion detection models without using labeled training data (i.e., with instances preclassified as being or not being an attack) in an automated manner and offer intrinsic ability to detect unknown attacks; i.e., 0-day attacks. Despite the advantages, it is still not easy to deploy them into a real network environment because they require several parameters during their building process, and thus IDS operators and managers suffer from tuning and optimizing the required parameters based on changes of their network characteristics. In this paper, we propose a new anomaly detection method by which we can automatically tune and optimize the values of parameters without predefining them. We evaluated the proposed method over real traffic data obtained from Kyoto University honeypots. The experimental results show that the performance of the proposed method is superior to that of the previous one. 2011 Elsevier Inc. All rights reserved.
Phase I study of the halichondrin B analogue eribulin mesylate in combination with cisplatin in advanced solid tumors

Background:Eribulin mesylate is a synthetic macrocyclic ketone analogue of Halichondrin B that has demonstrated high antitumor activity in preclinical and clinical settings. This phase I study aimed to determine the maximum tolerated dose (MTD), dose-limiting toxicities (DLTs), and pharmacokinetics in combination with cisplatin (CP) in patients with advanced solid tumours.Methods:Thirty-six patients with advanced solid tumours received eribulin mesylate 0.7–1.4 mg m−2 and CP 60–75 mg m−2. Eribulin mesylate was administered on days 1, 8, and 15 in combination with CP day 1 every 28-day cycle. The protocol was amended after dose level 4 (eribulin mesylate 1.4 mg m−2, CP 60 mg m−2) when it was not feasible to administer eribulin mesylate on day 15 because of neutropenia; the treatment schedule was changed to eribulin mesylate on days 1 and 8 and CP on day 1 every 21 days.Results:On the 28-day schedule, three patients had DLT during the first cycle: grade (G) 4 febrile neutropenia (1.0 mg m−2, 60 mg m−2); G 3 anorexia/fatigue/hypokalemia (1.2 mg m−2, 60 mg m−2); and G 3 stomatitis/nausea/vomiting/fatigue (1.4 mg m−2, 60 mg m−2). On the 21-day schedule, three patients had DLT during the first cycle: G 3 hypokalemia/hyponatremia (1.4 mg m−2, 60 mg m−2); G 4 mucositis (1.4 mg m−2, 60 mg m−2); and G 3 hypokalemia (1.2 mg m−2, 75 mg m−2). The MTD and recommended phase II dose was determined as eribulin mesylate 1.2 mg m−2 (days 1, 8) and CP 75 mg m−2 (day 1), on a 21-day cycle. Two patients had unconfirmed partial responses (PR) (pancreatic and breast cancers) and two had PR (oesophageal and bladder cancers).Conclusions:On the 21-day cycle, eribulin mesylate 1.2 mg m−2, administered on days 1 and 8, in combination with CP 75 mg m−2, administered on day 1 is well tolerated and showed preliminary anticancer activity.
The Perceval S aortic valve has the potential of shortening surgical time: does it also result in improved outcome?

BACKGROUND
Sutureless aortic valve prostheses have the potential of shortening surgical time. However, whether shorter operative times may also result in improved patient outcomes remains to be established.


METHODS
One hundred patients underwent minimally invasive isolated aortic valve replacement. Of these, 50 patients received a Perceval (Sorin Group, Saluggia, Italy) bioprosthesis (group P) and 50 patients received a non-Perceval valve (group NP).


RESULTS
The group P patients were older (77.5 ± 5.3 versus 71.7 ± 10 years, p = 0.001) and at higher risk (logistic European System for Cardiac Operative Risk Evaluation [EuroSCORE] 9.9 ± 6.5 versus 4.3 ± 1, p = 0.001) than group NP patients. One implant failure occurred in group P (p = 0.5), and conversion to full sternotomy was necessary in 1 patient from each group. Aortic cross-clamp and cardiopulmonary bypass times were 39.4% and 34% shorter in group P (both p < 0.001). Within 30 days, a total of 5 patients died (2 in group P and 3 in group NP, p = 0.5). No significant differences were observed between groups in postoperative arrhythmias and need for pacemaker implantation (p = 0.3 and p = 0.5, respectively). Despite the higher surgical risk, group P patients less frequently required blood transfusion (1.1 ± 1.1 units versus 2.3 ± 2.8 units, p = 0.007), and had a shorter intensive care unit stay (1.9 ± 0.7 versus 2.8 ± 1.9 days, p = 0.002) and a shorter intubation time (9.2 ± 3.6 hours versus 15 ± 13.8 hours, p = 0.01). Group NP patients had a mean prosthesis size significantly smaller than for group P (23 ± 2 mm versus 23.9 ± 1.1 mm, p = 0.01). The Perceval valve provided comparable hemodynamic performance to that of non-Perceval valves (mean gradient 8.4 ± 6 mm Hg versus 10 ± 4.9 mm Hg, p = 0.24).


CONCLUSIONS
Sutureless implantation of the Perceval valve is associated with shorter cross-clamp and cardiopulmonary bypass times, resulting in improved clinical outcome. In addition, it compares favorably with conventional valves in terms of mortality and outcome variables.
Validation of the MEDFICTS dietary assessment questionnaire in a diverse population.

BACKGROUND
The National Cholesterol Education Program (NCEP) recommends MEDFICTS, a rapid screening instrument for dietary fat, to assess adherence to the Adult Treatment Panel (ATP) III Therapeutic Lifestyle Changes (TLC) diet (score <40 points indicates intake of <7% of energy from saturated fat, <30% of energy from total fat, and <200 mg dietary cholesterol/day). MEDFICTS has only been validated in small, select populations and its utility in diverse clinical settings is unknown.


OBJECTIVE
To evaluate the ability of MEDFICTS to identify individuals who are nonadherent to a TLC diet in an ethnically diverse population that includes both English- and Spanish-speakers.


DESIGN
MEDFICTS was administered concurrently with the Gladys Block Food Frequency Questionnaire to participants (n=501; mean age 48+/-13.5 years; 36% nonwhite; 66% female) in the National Heart, Lung, and Blood Institute Family Intervention Trial for Heart Health (FIT Heart) at the baseline screening visit. Reliability and validity analyses were conducted overall and by sex, age, and race/ethnicity.


RESULTS
MEDFICTS score correlated significantly with percentage of energy from saturated fat (r=0.52, P<0.0001), percentage of energy from total fat (r=0.31, P<0.0001), and milligrams per day of dietary cholesterol (r=0.54, P<0.0001). Sensitivity of MEDFICTS to correctly identify TLC diet adherence was 85.7% and did not differ significantly by sex, age, or race/ethnicity. Specificity of MEDFICTS to correctly identify nonadherence to the TLC diet was low (56.9%) and significantly worse for women than men (48.4% vs 72.9%; P<0.0001), but did not differ significantly in older vs younger participants or among white, black, or Hispanic participants.


CONCLUSION
Our data suggest that sex-specific recalibration of MEDFICTS may improve specificity and clinical utility.
Comorbidities and risk of mortality in patients with chronic obstructive pulmonary disease.

RATIONALE
Patients with chronic obstructive pulmonary disease (COPD) are afflicted by comorbidities. Few studies have prospectively evaluated COPD comorbidities and mortality risk.


OBJECTIVES
To prospectively evaluate COPD comorbidities and mortality risk.


METHODS
We followed 1,664 patients with COPD in five centers for a median of 51 months. Systematically, 79 comorbidities were recorded. We calculated mortality risk using Cox proportional hazard, and developed a graphic representation of the prevalence and strength of association to mortality in the form of a "comorbidome". A COPD comorbidity index (COPD specific comorbidity test [COTE]) was constructed based on the comorbidities that increase mortality risk using a multivariate analysis. We tested the COTE index as predictor of mortality and explored whether the COTE index added predictive information when used with the validated BODE index.


MEASUREMENTS AND MAIN RESULTS
Fifteen of 79 comorbidities differed in prevalence between survivors and nonsurvivors. Of those, 12 predicted mortality and were integrated into the COTE index. Increases in the COTE index were associated with an increased risk of death from COPD-related (hazard ratio [HR], 1.13; 95% confidence interval, 1.08-1.18; P < 0.001) and non-COPD-related causes (HR, 1.18; 95% confidence interval, 1.15-1.21; P < 0.001). Further, increases in the BODE and COTE were independently associated with increased risk of death. A COTE score of greater than or equal to 4 points increased by 2.2-fold the risk of death (HR, 2.26-2.68; P < 0.001) in all BODE quartile.


CONCLUSIONS
Comorbidities are frequent in COPD and 12 of them negatively influence survival. A simple disease-specific comorbidities index (COTE) helps assess mortality risk in patients with COPD.
GENERALIZED AUTOREGRESSIVE CONDITIONAL CORRELATION

This paper develops a generalized autoregressive conditional correlation ~GARCC! model when the standardized residuals follow a random coefficient vector autoregressive process+ As a multivariate generalization of the Tsay ~1987, Journal of the American Statistical Association 82, 590– 604! random coefficient autoregressive ~RCA! model, the GARCC model provides a motivation for the conditional correlations to be time varying+ GARCC is also more general than the Engle ~2002, Journal of Business & Economic Statistics 20, 339–350! dynamic conditional correlation ~DCC! and the Tse and Tsui ~2002, Journal of Business & Economic Statistics 20, 351–362! varying conditional correlation ~VCC! models and does not impose unduly restrictive conditions on the parameters of the DCC model+ The structural properties of the GARCC model, specifically, the analytical forms of the regularity conditions, are derived, and the asymptotic theory is established+ The Baba, Engle, Kraft, and Kroner ~BEKK! model of Engle and Kroner ~1995, Econometric Theory 11, 122–150! is demonstrated to be a special case of a multivariate RCA process+ A likelihood ratio test is proposed for several special cases
Uptake and acceptability of antenatal HIV testing: randomised controlled trial of different methods of offering the test.

OBJECTIVE
To determine the uptake and acceptability of different methods of a universal offer of voluntary HIV testing to pregnant women.


DESIGN
Randomised controlled trial involving four combinations of written and verbal communication, followed by the direct offer of a test. The control group received no information and no direct offer of a test, although testing was available on request.


SETTING
Hospital antenatal clinic covering most of the population of the city of Edinburgh.


SUBJECTS
3024 pregnant women booking at the clinic over a 10 month period.


MAIN OUTCOME MEASURES
Uptake of HIV testing and women's knowledge, satisfaction, and anxiety.


RESULTS
Uptake rates were 6% for those in the control group and 35% for those directly offered the test. Neither the style of leaflet nor the length of discussion had an effect on uptake. Significant independent predictors of uptake were a direct test offer; the midwife seen; and being unmarried, previously tested, and younger age. Knowledge of the specific benefits of testing increased with the amount of information given, but neither satisfaction nor anxiety was affected by the type of offer.


CONCLUSIONS
The universal offer of HIV testing is not intrusive and is acceptable to pregnant women. A policy of offering the HIV test to all women resulted in higher uptake and did not increase anxiety or dissatisfaction. Uptake depends more on the midwife than the method of offering the test. Low uptake rates and inadequate detection of HIV infection point to the need to assess a more routine approach to testing.
Far cortical locking can reduce stiffness of locked plating constructs while retaining construct strength.

BACKGROUND
Several strategies to reduce construct stiffness have been proposed to promote secondary bone healing following fracture fixation with locked bridge plating constructs. However, stiffness reduction is typically gained at the cost of construct strength. In the present study, we tested whether a novel strategy for stiffness reduction, termed far cortical locking, can significantly reduce the stiffness of a locked plating construct while retaining its strength.


METHODS
Locked plating constructs and far cortical locking constructs were tested in a diaphyseal bridge plating model of the non-osteoporotic femoral diaphysis to determine construct stiffness in axial compression, torsion, and bending. Subsequently, constructs were dynamically loaded until failure in each loading mode to determine construct strength and failure modes. Finally, failure tests were repeated in a validated model of the osteoporotic femoral diaphysis to determine construct strength and failure modes in a worst-case scenario of bridge plating in osteoporotic bone.


RESULTS
Compared with the locked plating constructs, the initial stiffness of far cortical locking constructs was 88% lower in axial compression (p < 0.001), 58% lower in torsion (p < 0.001), and 29% lower in bending (p < 0.001). Compared with the locked plating constructs, the strength of far cortical locking constructs was 7% lower (p = 0.005) and 16% lower (p < 0.001) under axial compression in the non-osteoporotic and osteoporotic diaphysis, respectively. However, far cortical locking constructs were 54% stronger (p < 0.001) and 9% stronger (p = 0.04) under torsion and 21% stronger (p < 0.001) and 20% stronger (p = 0.02) under bending than locked plating constructs in the non-osteoporotic and osteoporotic diaphysis, respectively. Within the initial stiffness range, far cortical locking constructs generated nearly parallel interfragmentary motion. Locked plating constructs generated significantly less motion at the near cortex adjacent to the plate than at the far cortex (p < 0.01).


CONCLUSIONS
Far cortical locking significantly reduces the axial stiffness of a locked plating construct. This gain in flexibility causes only a modest reduction in axial strength and increased torsional and bending strength.
Extracting linguistic rules from data sets using fuzzy logic and genetic algorithms

Linguistic rules in natural language are useful and consistent with human way of thinking. They are very important in multi-criteria decision making due to their interpretability. In this paper, our discussions concentrate on extracting linguistic rules from data sets. In the end, we firstly analyze how to extract complex linguistic data summaries based on fuzzy logic. Then, we formalize linguistic rules based on complex linguistic data summaries, in which, the degree of confidence of linguistic rules from a data set can be explained by linguistic quantifiers and its linguistic truth from the fuzzy logical point of view. In order to obtain a linguistic rule with a higher degree of linguistic truth, a genetic algorithm is used to optimize the number and parameters of membership functions of linguistic values. Computational results show that the proposed method is an alternative method for extracting linguistic rules with linguistic truth from data sets. & 2011 Elsevier B.V. All rights reserved.