LLukas22/scidocs huggingface dataset:
Three-dimensional analysis of impacted maxillary third molars: A cone-beam computed tomographic study of the position and depth of impaction

PURPOSE
The classification of impacted maxillary third molars (IMTMs) facilitates interdisciplinary communication and helps estimate the degree of surgical difficulty. Thus, this study aimed to develop a 3-dimensional classification of the position and depth of impaction of IMTMs and to estimate their prevalence with respect to gender and age.


MATERIALS AND METHODS
This cross-sectional retrospective study analyzed images in sagittal and coronal cone-beam computed tomography (CBCT) sections of 300 maxillary third molars. The proposed classification was based on 3 criteria: buccolingual position (buccal, lingual, or central), mesial-distal position (mesioangular, vertical, or distoangular), and depth of impaction (low, medium, or high). CBCT images of IMTMs were classified, and the associations of the classifications with gender and age were examined using analysis of variance with the Scheffé post-hoc test. To determine the associations among the 3 classifications, the chi-square test was used (P<.05).


RESULTS
No significant association of the classifications with gender was observed. Age showed a significant relationship with depth of impaction (P=.0001) and mesial-distal position (P=.005). The most common positions were buccal (n=222), vertical (n=184), and low (n=124). Significant associations among the 3 tested classifications were observed.


CONCLUSION
CBCT enabled the evaluation of IMTMs in a 3-dimensional format, and we developed a proposal for a new classification of the position and depth of impaction of IMTMs.
Cemented versus Uncemented Hemiarthroplasty for Femoral Neck Fractures in Elderly Patients: A Meta-Analysis

OBJECTIVE
Controversy still exists regarding using cemented or uncemented hemiarthroplasty for femoral neck fractures in elderly patients. The aim of this study is to compare the effectiveness and safety of the two surgical techniques in femoral neck fracture patients over 70 years old.


METHODS
We searched PUBMED, EMBASE, Cochrane Library, CNKI and VIP Database from inception to December 2012 for relevant randomized controlled trials (RCTs). Outcomes of interest include postoperative hip function, residue pain, complication rates, mortality, reoperation rate, operation time and intraoperative blood loss. Odds ratios (OR) and weighted mean differences (WMD) from each trial were pooled using random-effects model or fixed-effects model given on the heterogeneity of the included studies.


RESULTS
7 RCTs involving 1,125 patients (1,125 hips) were eligible for meta-analysis. Our results demonstrate that cemented hemiarthroplasty is associated with better postoperative hip function (OR = 0.48, 95% CI, 0.31-0.76; P = 0.002), lower residual pain (OR = 0.43, 95%CI, 0.29-0.64; P<0.0001), less implant-related complications (OR = 0.15, 95%CI, 0.09-0.26; P<0.00001) and longer operation time (WMD = 7.43 min, 95% CI, 5.37-9.49 min; P<0.00001). No significant difference was observed between the two groups in mortality, cardiovascular and cerebrovascular complications, local complications, general complications, reoperation rate and intraoperative blood loss.


CONCLUSIONS
Compared with uncemented hemiarthroplasty, the existing evidence indicates that cemented hemiarthroplasty can achieve better hip function, lower residual pain and less implant-related complications with no increased risk of mortality, cardiovascular and cerebrovascular complications, general complications, local complications and reoperation rate in treating elderly patients with femoral neck fractures.
Gastro-oesophageal reflux related cough and its response to laparoscopic fundoplication.

BACKGROUND
This study was designed to determine prospectively the rate of cough before and after laparoscopic Nissen fundoplication performed for the control of gastro-oesophageal reflux disease.


METHODS
One hundred and ninety five consecutive patients (76 men) of mean (SD) age 46.9 (14.1) years with proven gastro-oesophageal reflux disease, who were either on long term omeprazole (n = 187) or who had not responded to a trial of omeprazole (n = 8), took part in the study which was carried out in a university teaching hospital that included a regional respiratory referral centre. Patients underwent oesophageal manometry, 24 hour oesophageal pH testing, and symptom score evaluation by an independent observer before and six months after laparoscopic Nissen fundoplication.


RESULTS
One hundred and thirty three patients presented with reflux symptoms and 62 with respiratory symptoms; 68% of patients complained of cough before surgery (86% with respiratory symptoms, 60% with gastrointestinal symptoms). The percentage reflux time in 24 hours fell significantly (p < 0.0001) from a mean (SD) of 9.38 (10.99)% to 1.22 (2.92)%, lower oesophageal sphincter tone rose significantly (p < 0.0001) from a mean (SD) of 7.71 (5.90) mm Hg to 21.74 (10.84) mm Hg, and the cough score fell from a median value of 8.0 (IQR 12.0) to 0 (IQR 3) following surgery. Of the patients with cough, 51% were cough free after surgery and 31% improved. The patients with respiratory symptoms had a higher cough score before (median 12.0 (IQR 5.5) versus 4.0 (IQR 8.75), p < 0.0001) and after surgery (median 1 (7.5) versus 0.0 (IQR 1.0), p = 0.0045) than those with gastrointestinal symptoms.


CONCLUSIONS
Patients who present to gastroenterologists with severe reflux commonly complain of cough. Laparoscopic Nissen fundoplication is effective in the control of cough in patients with gastro-oesophageal reflux disease, with or without primary respiratory disease.
Assessing canopy PRI for water stress detection with diurnal airborne imagery

A series of diurnal airborne campaigns were conducted over an orchard field to assess the canopy Photochemical Reflectance Index (PRI) as an indicator of water stress. Airborne campaigns over two years were conducted with the Airborne Hyperspectral Scanner (AHS) over an orchard field to investigate changes in PRI, in the Transformed Chlorophyll Absorption in Reflectance Index (TCARI) normalized by the Optimized SoilAdjusted Vegetation Index (OSAVI) (TCARI/OSAVI), and in the Normalized Difference Vegetation Index (NDVI) as function of field-measured physiological indicators of water stress, such as stomatal conductance, stem water potential, steady-state fluorescence, and crown temperature. The AHS sensor was flown at three times on each 2004 and 2005 years, collecting 2 m spatial resolution imagery in 80 spectral bands in the 0.43– 12.5 μm spectral range. Indices PRI, TCARI/OSAVI, and NDVI were calculated from reflectance bands, and thermal bands were assessed for the retrieval of land surface temperature, separating pure crowns from shadows and sunlit soil pixels. The Photochemical Reflectance Index, originally developed for xanthophyll cycle pigment change detection was calculated to assess its relationship with water stress at a canopy level, and more important, to assess canopy structural and viewing geometry effects for water stress detection in diurnal airborne experiments. The FLIGHT 3D canopy reflectance model was used to simulate the bi-directional reflectance changes as function of the viewing geometry, background and canopy structure. This manuscript demonstrates that the airborne-level PRI index is sensitive to the de-epoxidation of the xanthophyll pigment cycle caused by water stress levels, but affected diurnally by the confounding effects of BRDF. Among the three vegetation indices calculated, only airborne PRI demonstrated sensitivity to diurnal changes in physiological indicators of water stress, such as canopy temperature minus air temperature (Tc–Ta), stomatal conductance (G), and stem water potential (ψ) measured in the field at the time of each image acquisition. No relationships were found from the diurnal experiments between NDVI and TCARI/OSAVI with the tree-measured physiological measures. FLIGHT model simulations of PRI demonstrated that PRI is highly affected by the canopy structure and background. © 2007 Elsevier Inc. All rights reserved.
A new period of volcanogenic massive sulfide formation in the Yilgarn: a volcanological study of the ca 2.76 Ga Hollandaire VMS deposit, Yilgarn Craton, Western Australia

This research was supported by Silver Lake Resources 
through an Honours project by S. E. Hull and through 
ongoing research as part of ARC Linkage Project 
LP110200747.
The differential broadens. EUS FNA appearance and cytological findings of pancreatic angiomyolipoma.

CONTEXT
Angiomyolipoma is a rare tumor characterized histologically by a mixture of spindle cells, adipose tissue, epithelioid cells, and vascular tissue. It usually involves the kidney followed by the liver whereby the majority of affected patients are female, and many cases arise in the setting of tuberous sclerosis.


CASE REPORT
We report a case of a 33-year-old female with an asymptomatic incidental right renal mass suggestive of an angiomyolipoma in conjunction with numerous pancreatic masses.


CONCLUSIONS
The utility of EUS in the differential diagnosis of pancreatic tumors is well established. This is the first known reported EUS detection and FNA confirmation of angiomyolipoma metastatic to the pancreas and should now be added to the already broad differential of metastatic pancreatic tumors.
Comparison between transcatheter and surgical prosthetic valve implantation in patients with severe aortic stenosis and reduced left ventricular ejection fraction.

BACKGROUND
Patients with severe aortic stenosis and reduced left ventricular ejection fraction (LVEF) have a poor prognosis with conservative therapy but a high operative mortality when treated surgically. Recently, transcatheter aortic valve implantation (TAVI) has emerged as an alternative to surgical aortic valve replacement (SAVR) for patients considered at high or prohibitive operative risk. The objective of this study was to compare TAVI and SAVR with respect to postoperative recovery of LVEF in patients with severe aortic stenosis and reduced LV systolic function.


METHODS AND RESULTS
Echocardiographic data were prospectively collected before and after the procedure in 200 patients undergoing SAVR and 83 patients undergoing TAVI for severe aortic stenosis (aortic valve area ≤1 cm(2)) with reduced LV systolic function (LVEF ≤50%). TAVI patients were significantly older (81±8 versus 70±10 years; P<0.0001) and had more comorbidities compared with SAVR patients. Despite similar baseline LVEF (34±11% versus 34±10%), TAVI patients had better recovery of LVEF compared with SAVR patients (ΔLVEF, 14±15% versus 7±11%; P=0.005). At the 1-year follow-up, 58% of TAVI patients had a normalization of LVEF (>50%) as opposed to 20% in the SAVR group. On multivariable analysis, female gender (P=0.004), lower LVEF at baseline (P=0.005), absence of atrial fibrillation (P=0.01), TAVI (P=0.007), and larger increase in aortic valve area after the procedure (P=0.01) were independently associated with better recovery of LVEF.


CONCLUSION
In patients with severe aortic stenosis and depressed LV systolic function, TAVI is associated with better LVEF recovery compared with SAVR. TAVI may provide an interesting alternative to SAVR in patients with depressed LV systolic function considered at high surgical risk.
Human papilloma virus infection and cervical dysplasia.

UNLABELLED
Pap testing is considered to be the best screening tool for cervical cancer but there is currently great interest in the possible application of human papilloma virus (HPV) testing to supplement Pap screening for cervical cancer.


AIM
To determine the prevalence of high-risk HPV types in the studied population and to explore the association between high-risk HPV types and cervical dysplasia.


MATERIAL AND METHODS
Cross-sectional study conducted at the Iasi Cuza Voda Obstetrics-Gynecology Hospital and Suceava County Hospital. 332 women who underwent colposcopy for cervical lesions between 2006 and 2011 were included in this study.


RESULTS
The overall prevalence of HPV was 57.23%. HPV prevalence differs significantly in the three age groups up to 50 years. It was highest in patients below the age of 40 and progressively lower with advancing age. The overall prevalence of cervical dysplasia was 56.62%. The prevalence of cervical dysplasia was highest in the age groups up to 40 years. The most important determinant of HPV infection is age.


CONCLUSIONS
Persistence of HPV appears to be associated with progression to squamous intraepithelial lesion. Dysplasia is often missed in a cervical sample either because of human error in screening and interpretation, or because of suboptimal quality of Pap smear. Incorporation of HPV testing into the present Pap screening program has the potential of making screening for cervical cancer more effective, and a necessary prelude to assessing this is by determining the prevalence of the high-risk types.
QuickTime VR: an image-based approach to virtual environment navigation

Traditionally, virtual reality systems use 3D computer graphics to model and render virtual environments in real-time. This approach usually requires laborious modeling and expensive special purpose rendering hardware. The rendering quality and scene complexity are often limited because of the real-time constraint. This paper presents a new approach which uses 360-degree cylindrical panoramic images to compose a virtual environment. The panoramic image is digitally warped on-the-fly to simulate camera panning and zooming. The panoramic images can be created with computer rendering, specialized panoramic cameras or by "stitching" together overlapping photographs taken with a regular camera. Walking in a space is currently accomplished by "hopping" to different panoramic points. The image-based approach has been used in the commercial product QuickTime VR, a virtual reality extension to Apple Computer's QuickTime digital multimedia framework. The paper describes the architecture, the file format, the authoring process and the interactive players of the VR system. In addition to panoramic viewing, the system includes viewing of an object from different directions and hit-testing through orientation-independent hot spots. CR
The Aharonov-Bohm effects: Variations on a subtle theme

© 2009 American Institute of Physics, S-0031-9228-0909-020-6 Quantum phenomena that were once thought to limit measurement capabilities are now being harnessed to enhance them and to improve the sensitivity of nanometer-size devices. Persistent questioning and probing of quantum phenomena has yielded many such advances. However, the Aharonov–Bohm effect, a modern cornerstone of quantum mechanics, is not yet a good example of that kind of progress. The AB effect was already implicit in the 1926 Schrödinger equation, but it would be another three decades before theorists Yakir Aharonov and David Bohm pointed it out.1 And to this day, the investigation and exploitation of the AB effect remain far from finished. Our discussion of the AB effect begins with a seemingly innocent question: What happens to an electron as it passes by an infinitely long ideal solenoid? One might expect that the electron is unaffected. Outside the solenoid, the magnetic and electric fields B and E, and thus the Lorentz force, are all zero. But in quantum mechanics one describes an interaction not by the forces involved but rather by the Hamiltonian. The canonical momentum in the electromagnetic Hamiltonian has a term proportional to the magnetic vector potential A, which is defined (with some gauge freedom) by B = ∇ × A. Before the AB paper, the vector potential was generally thought of as a useful mathematical artifice without independent physical reality. Aharonov and Bohm changed all that. The Aharonov–Bohm effects: Variations on a subtle theme
Zero-Shot Dialog Generation with Cross-Domain Latent Actions

This paper introduces zero-shot dialog generation (ZSDG), as a step towards neural dialog systems that can instantly generalize to new situations with minimal data. ZSDG enables an end-to-end generative dialog system to generalize to a new domain for which only a domain description is provided and no training dialogs are available. Then a novel learning framework, Action Matching, is proposed. This algorithm can learn a cross-domain embedding space that models the semantics of dialog responses which, in turn, lets a neural dialog generation model generalize to new domains. We evaluate our methods on a new synthetic dialog dataset, and an existing human-human dialog dataset. Results show that our method has superior performance in learning dialog models that rapidly adapt their behavior to new domains and suggests promising future research.1
Low-dose naltrexone for the treatment of fibromyalgia: findings of a small, randomized, double-blind, placebo-controlled, counterbalanced, crossover trial assessing daily pain levels.

OBJECTIVE
To determine whether low dosages (4.5 mg/day) of naltrexone reduce fibromyalgia severity as compared with the nonspecific effects of placebo. In this replication and extension study of a previous clinical trial, we tested the impact of low-dose naltrexone on daily self-reported pain. Secondary outcomes included general satisfaction with life, positive mood, sleep quality, and fatigue.


METHODS
Thirty-one women with fibromyalgia participated in the randomized, double-blind, placebo-controlled, counterbalanced, crossover study. During the active drug phase, participants received 4.5 mg of oral naltrexone daily. An intensive longitudinal design was used to measure daily levels of pain.


RESULTS
When contrasting the condition end points, we observed a significantly greater reduction of baseline pain in those taking low-dose naltrexone than in those taking placebo (28.8% reduction versus 18.0% reduction; P = 0.016). Low-dose naltrexone was also associated with improved general satisfaction with life (P = 0.045) and with improved mood (P = 0.039), but not improved fatigue or sleep. Thirty-two percent of participants met the criteria for response (defined as a significant reduction in pain plus a significant reduction in either fatigue or sleep problems) during low-dose naltrexone therapy, as contrasted with an 11% response rate during placebo therapy (P = 0.05). Low-dose naltrexone was rated equally tolerable as placebo, and no serious side effects were reported.


CONCLUSION
The preliminary evidence continues to show that low-dose naltrexone has a specific and clinically beneficial impact on fibromyalgia pain. The medication is widely available, inexpensive, safe, and well-tolerated. Parallel-group randomized controlled trials are needed to fully determine the efficacy of the medication.
Progress in the pathogenesis and genetics of Parkinson's disease.

Recent progresses in the pathogenesis of sporadic Parkinson's disease (PD) and genetics of familial PD are reviewed. There are common molecular events between sporadic and familial PD, particularly between sporadic PD and PARK1-linked PD due to alpha-synuclein (SNCA) mutations. In sporadic form, interaction of genetic predisposition and environmental factors is probably a primary event inducing mitochondrial dysfunction and oxidative damage resulting in oligomer and aggregate formations of alpha-synuclein. In PARK1-linked PD, mutant alpha-synuclein proteins initiate the disease process as they have increased tendency for self-aggregation. As highly phosphorylated aggregated proteins are deposited in nigral neurons in PD, dysfunctions of proteolytic systems, i.e. the ubiquitin-proteasome system and autophagy-lysosomal pathway, seem to be contributing to the final neurodegenerative process. Studies on the molecular mechanisms of nigral neuronal death in familial forms of PD will contribute further on the understanding of the pathogenesis of sporadic PD.
Microarray analysis of early stage serous ovarian cancers shows profiles predictive of favorable outcome.

PURPOSE
Although few women with advanced serous ovarian cancer are cured, detection of the disease at an early stage is associated with a much higher likelihood of survival. We previously used gene expression array analysis to distinguish subsets of advanced cancers based on disease outcome. In the present study, we report on gene expression of early-stage cancers and validate our prognostic model for advanced-stage cancers.


EXPERIMENTAL DESIGN
Frozen specimens from 39 stage I/II, 42 stage III/IV, and 20 low malignant potential cancers were obtained from four different sites. A linear discriminant model was used to predict survival based upon array data.


RESULTS
We validated the late-stage survival model and show that three of the most differentially expressed genes continue to be predictive of outcome. Most early-stage cancers (38 of 39 invasive, 15 of 20 low malignant potential) were classified as long-term survivors (median probabilities 0.97 and 0.86). MAL, the most differentially expressed gene, was further validated at the protein level and found to be an independent predictor of poor survival in an unselected group of advanced serous cancers (P = 0.0004).


CONCLUSIONS
These data suggest that serous ovarian cancers detected at an early stage generally have a favorable underlying biology similar to advanced-stage cases that are long-term survivors. Conversely, most late-stage ovarian cancers seem to have a more virulent biology. This insight suggests that if screening approaches are to succeed it will be necessary to develop approaches that are able to detect these virulent cancers at an early stage.
Design and Implementation of a Homomorphic-Encryption Library

We describe the design and implementation of a software library that implements the Brakerski-Gentry-Vaikuntanathan (BGV) homomorphic encryption scheme, along with many optimizations to make homomorphic evaluation runs faster, focusing mostly on effective use of the Smart-Vercauteren ciphertext packing techniques. Our library is written in C++ and uses the NTL mathematical library. It is distributed under the terms of the GNU General Public License (GPL). Partially supported by DARPA under agreement number FA8750-11-C-0096. The U.S. Government is authorized to reproduce and distribute reprints for Governmental purposes notwithstanding any copyright notation thereon. The views and conclusions contained herein are those of the authors and should not be interpreted as necessarily representing the official policies or endorsements, either expressed or implied, of DARPA or the U.S. Government. Distribution Statement “A” (Approved for Public Release, Distribution Unlimited). Also partially supported by the Intelligence Advanced Research Projects Activity (EARP) via Department of Interior National Business Center (DoI/NBC) contract number D11PC20202. The U.S. Government is authorized to reproduce and distribute reprints for Governmental purposes notwithstanding any copyright annotation thereon. Disclaimer: The views and conclusions contained herein are those of the authors and should not be interpreted as necessarily representing the official policies or endorsements, either expressed or implied, of IARPA, DoI/NBC, or the U.S. Government.