LLukas22/scidocs huggingface dataset:
Model for assessing cardiovascular risk in a Korean population.

BACKGROUND
A model for predicting cardiovascular disease in Asian populations is limited.


METHODS AND RESULTS
In total, 57 393 consecutive asymptomatic Korean individuals aged 30 to 80 years without a prior history of cardiovascular disease who underwent a general health examination were enrolled. Subjects were randomly classified into the train (n=45 914) and validation (n=11 479) cohorts. Thirty-one possible risk factors were assessed. The cardiovascular event was a composite of cardiovascular death, myocardial infarction, and stroke. In the train cohort, the C-index (95% confidence interval) and Akaike Information Criterion were used to develop the best-fitting prediction model. In the validation cohort, the predicted versus the observed cardiovascular event rates were compared by the C-index and Nam and D'Agostino χ(2) statistics. During a median follow-up period of 3.1 (interquartile range, 1.9-4.3) years, 458 subjects had 474 cardiovascular events. In the train cohort, the best-fitting model consisted of age, diabetes mellitus, hypertension, current smoking, family history of coronary heart disease, white blood cell, creatinine, glycohemoglobin, atrial fibrillation, blood pressure, and cholesterol (C-index =0.757 [0.726-0.788] and Akaike Information Criterion =7207). When this model was tested in the validation cohort, it performed well in terms of discrimination and calibration abilities (C-index=0.760 [0.693-0.828] and Nam and D'Agostino χ(2) statistic =0.001 for 3 years; C-index=0.782 [0.719-0.846] and Nam and D'Agostino χ(2) statistic=1.037 for 5 years).


CONCLUSIONS
A risk model based on traditional clinical and biomarkers has a feasible model performance in predicting cardiovascular events in an asymptomatic Korean population.
Effect of stitch length on wound complications after closure of midline incisions: a randomized controlled trial.

HYPOTHESIS
In midline incisions closed with a single-layer running suture, the rate of wound complications is lower when a suture length to wound length ratio of at least 4 is accomplished with a short stitch length rather than with a long one.


DESIGN
Prospective randomized controlled trial.


SETTING
Surgical department.


PATIENTS
Patients operated on through a midline incision.


INTERVENTION
Wound closure with a short stitch length (ie, placing stitches <10 mm from the wound edge) or a long stitch length.


MAIN OUTCOME MEASURES
Wound dehiscence, surgical site infection, and incisional hernia.


RESULTS
In all, 737 patients were randomized: 381 were allocated to a long stitch length and 356, to a short stitch length. Wound dehiscence occurred in 1 patient whose wound was closed with a long stitch length. Surgical site infection occurred in 35 of 343 patients (10.2%) in the long stitch group and in 17 of 326 (5.2%) in the short stitch group (P = .02). Incisional hernia was present in 49 of 272 patients (18.0%) in the long stitch group and in 14 of 250 (5.6%) in the short stitch group (P < .001). In multivariate analysis, a long stitch length was an independent risk factor for both surgical site infection and incisional hernia.


CONCLUSION
In midline incisions closed with a running suture and having a suture length to wound length ratio of at least 4, current recommendations of placing stitches at least 10 mm from the wound edge should be changed to avoid patient suffering and costly wound complications.


TRIAL REGISTRATION
clinicaltrials.gov Identifier: NCT00508053.
In-Situ, Real-Time Detector for Faults in Solder Joint Networks Belonging to Operational, Fully Programmed Field Programmabmle Gate Arrays (FPGAS)

In this paper we introduce an in-situ solder-joint built-in self-test (SJ BIST) for detecting high-resistance faults in operational, fully-programmed field programmable gate arrays (FPGAs). The approach is simple to implement, offers a method to detect high- resistance faults that result from damaged solder-joints, and uses a maximum of one small capacitor externally-connected to each selected test pin or each group of two test pins.
Gum chewing promotes bowel motility after a radical retropubic prostatectomy.

AIM
To investigate the efficacy of gum chewing in aiding the recovery of bowel motility after a radical retropubic prostatectomy


METHODS
Thirty-seven patients who underwent retropubic radical prostatectomy from January 2010 to February 2012 for localized prostate cancer were enrolled. They were divided, in an alternate pattern, into the gum-chewing group and the control group. Patient demographics and operative outcomes were compared. The time to first postoperative passage of flatus and bowel movement, the duration of hospital stay and the side effects were recorded.


RESULTS
The patients' demographics and operative outcomes showed no differences between the control (n = 19) and gum-chewing (n = 18) groups. The time to flatus was significantly shorter in the gum-chewing group than in the control group (27.1 vs 39.8 h), and the time-to-first bowel movement was faster in gum-chewing patients (46.1 vs 60.7 h). Surgical hospital stay was shorter in gum-chewing group than in the control group (5.1 vs 6.4 days).


CONCLUSIONS
Gum chewing has a positive effect on the recovery of bowel motility and reduction of surgical hospital stay after a radical prostatectomy. Although retropubic radical prostatectomy does not involve bowel manipulation, gum chewing is an effective and side-effect-free method for the resolution of ileus after surgery.
Designing online selling mechanisms: Transparency levels and prices

Sellers increasingly compete with innovative Internet-based selling mechanisms, revealing or concealing market information. Transparency strategy involves design choices by firms that influence the availability and accessibility of information about products and prices. We develop decision support models for suppliers to set prices for online mechanisms with different transparency levels. We then empirically analyze the price levels set by airlines across transparent and opaque online travel agencies. Our results suggest that airlines can increase profit by increasing price differentials or influencing OTA transparency differences. We also discuss application generality and limitations of our results.
Prepregnancy BMI influences maternal and fetal outcomes in women with isolated gestational hyperglycaemia: a multicentre study.

AIM
This multicentre study analyzed the maternal and fetal outcomes of women who had one elevated 3-h oral glucose tolerance test (isolated gestational hyperglycaemia [IGH]).


METHODS
From 1999 to 2003, data were collected for 606 IGH women from 31 Italian obstetric or diabetic centres, including time and mode of delivery, gestational hypertension, preeclampsia, eclampsia, congenital malformations, and neonatal mortality and morbidity, to compare them with the general pregnant Italian population. A prognostic model for the outcome of pregnancy was constructed, and the concurrence of certain specified conditions was considered a positive outcome, whereas pregnancies that failed to meet one or more of the stated conditions were classified as "complicated".


RESULTS
Macrosomia was significantly more frequent in women with IGH than in the normal pregnant population (10.7 vs 7.4%, respectively; P=0.003). Stillbirth and neonatal mortality rates did not differ from those in normal pregnancies, while a slight rise in the frequency of major malformations was not statistically significant (1.48 vs 0.89%, respectively; P<0.11). Multivariate logistic analyses confirmed that the prepregnancy body mass index (BMI) was an independent predictor of a complicated pregnancy. As for fetal growth, multivariate logistic analyses according to BMI showed that being overweight or obese were strong predictors of macrosomia.


CONCLUSION
These findings in a large cohort of Italian women with IGH confirm the detrimental effect of even minimally altered glucose tolerance on fetal outcome. Also, prepregnancy obesity plays an important role in raising the risk of adverse perinatal outcomes in such patients.
Predictors of adherence to a skill-building intervention in dementia caregivers.

BACKGROUND
Treatment adherence is a widely recognized problem in health services but understudied in caregiver intervention research. This study examines caregiver sociodemographic and psychological characteristics, patient illness severity, and treatment implementation factors as predictors of caregiver adherence to a skills training intervention to help families manage dementia care problems at home.


METHODS
The sample consisted of 105 caregivers randomized to the Home Environmental Skill-Building Program at the Philadelphia site of the National Institutes of Health (NIH) Resources for Enhancing Alzheimer's Caregiver Health (REACH I). The intervention, implemented by occupational therapists, consisted of education, problem solving, communication, environmental and task simplification techniques, and home modifications. Adherence was measured by a proportion score representing the percentage of strategies used by participants compared to the total number of strategies prescribed during intervention (Strategy Use).


RESULTS
Regression analysis with intraclass correlation adjustment for interventionist effects revealed that caregivers with better physical health (p <.001), greater treatment exposure (p <.001), more problem areas addressed (p =.012), and for whom more active therapeutic techniques (role play) were used (p =.004) demonstrated greater adherence. Other caregiver characteristics, patient cognitive impairment, and troublesome behaviors were not significantly related to caregiver adherence.


CONCLUSIONS
Modifiable caregiver and treatment implementation factors, including active engagement of caregivers, were associated with adherence, whereas patient characteristics were not. Caregivers with poor health may be at risk for not benefiting from intervention, suggesting that efforts, including instruction in preventive care and allocating time to attend to their own health care needs, be directed towards improving their health.
Computing and Applying Trust in Web-based Social Networks

Title of dissertation: COMPUTING AND APPLYING TRUST IN WEB-BASED SOCIAL NETWORKS Jennifer Ann Golbeck, Doctor of Philosophy, 2005 Dissertation directed by: Professor James Hendler Department of Computer Science The proliferation of web-based social networks has lead to new innovations in social networking, particularly by allowing users to describe their relationships beyond a basic connection. In this dissertation, I look specifically at trust in web-based social networks, how it can be computed, and how it can be used in applications. I begin with a definition of trust and a description of several properties that affect how it is used in algorithms. This is complemented by a survey of web-based social networks to gain an understanding of their scope, the types of relationship information available, and the current state of trust. The computational problem of trust is to determine how much one person in the network should trust another person to whom they are not connected. I present two sets of algorithms for calculating these trust inferences: one for networks with binary trust ratings, and one for continuous ratings. For each rating scheme, the algorithms are built upon the defined notions of trust. Each is then analyzed theoretically and with respect to simulated and actual trust networks to determine how accurately they calculate the opinions of people in the system. I show that in both rating schemes the algorithms presented can be expected to be quite accurate. These calculations are then put to use in two applications. FilmTrust is a website that combines trust, social networks, and movie ratings and reviews. Trust is used to personalize the website for each user, displaying recommended movie ratings, and ordering reviews by relevance. I show that, in the case where the user's opinion is divergent from the average, the trust-based recommended ratings are more accurate than several other common collaborative filtering techniques. The second application is TrustMail, an email client that uses the trust rating of each sender as a score for the message. Users can then sort messages according to their trust value. I conclude with a description of other applications where trust inferences can be used, and how the lessons from this dissertation can be applied to infer information about relationships in other complex systems. COMPUTING AND APPLYING TRUST IN WEB-BASED SOCIAL NETWORKS by Jennifer Ann Golbeck Dissertation Submitted to the Faculty of the Graduate School of the University of Maryland, College Park in partial fulfillment of the requirements for the degree of Doctor of Philosophy 2005 Advisory Committee: Professor James Hendler, Chair/Advisor Professor Ashok Agrawala Professor Mark Austin Professor Benjamin Bederson Professor Lise Getoor Professor Ben Shneiderman ©Copyright by Jennifer Ann Golbeck 2005
Специальные знания сила

The author considers the substance and nature of criminalistic knowledge, its role and function in efforts to detect and disclose crimes and crminalistic didactics.
Abdominal obesity and metabolic syndrome: exercise as medicine?

Background
Metabolic syndrome is defined as a cluster of at least three out of five clinical risk factors: abdominal (visceral) obesity, hypertension, elevated serum triglycerides, low serum high-density lipoprotein (HDL) and insulin resistance. It is estimated to affect over 20% of the global adult population. Abdominal (visceral) obesity is thought to be the predominant risk factor for metabolic syndrome and as predictions estimate that 50% of adults will be classified as obese by 2030 it is likely that metabolic syndrome will be a significant problem for health services and a drain on health economies.Evidence shows that regular and consistent exercise reduces abdominal obesity and results in favourable changes in body composition. It has therefore been suggested that exercise is a medicine in its own right and should be prescribed as such.


Purpose of this review
This review provides a summary of the current evidence on the pathophysiology of dysfunctional adipose tissue (adiposopathy). It describes the relationship of adiposopathy to metabolic syndrome and how exercise may mediate these processes, and evaluates current evidence on the clinical efficacy of exercise in the management of abdominal obesity. The review also discusses the type and dose of exercise needed for optimal improvements in health status in relation to the available evidence and considers the difficulty in achieving adherence to exercise programmes.


Conclusion
There is moderate evidence supporting the use of programmes of exercise to reverse metabolic syndrome although at present the optimal dose and type of exercise is unknown. The main challenge for health care professionals is how to motivate individuals to participate and adherence to programmes of exercise used prophylactically and as a treatment for metabolic syndrome.
A phase I and pharmacokinetic study of ILX-295501, an oral diarylsulfonylurea, on a weekly for 3 weeks every 4-week schedule in patients with advanced solid malignancies.

PURPOSE
This study was conducted to assess the feasibility of administering the oral diarylsulfonylurea (DSU) ILX-295501 on a weekly for 3 weeks every 4-week schedule. The study also sought to determine the maximum tolerated dose (MTD) of ILX-295501 on this schedule, characterize its pharmacokinetic behavior, and seek preliminary evidence of anticancer activity.


EXPERIMENTAL DESIGN
The initial starting dose of ILX-295501 was 100 mg/m(2), which was equivalent to one-sixth of the highest dose that did not induce irreversible toxicity in dogs, and, using a modified Fibonnaci search scheme to guide dose level selection, the following dose levels were evaluated: 100, 200, 400, 600, 900, 1350, and 1800 mg/m(2). Because severe toxicities were being reported in other trials at doses that encompassed this range and a cumulative toxicity profile was emerging, the study was suspended and then reinitiated to further reevaluate the lower dosing range. In the second part of the study, the following dose levels were selected a priori for evaluation: 400, 800, 1000, 1250, and 1500 mg/m(2); and a modified continual reassessment model was used for dose assignment to determine the MTD, which was defined a priori as the highest dose in which the incidence of dose-limiting toxicity in the first course did not exceed 20%.


RESULTS
Forty-nine patients were treated with 142 courses of ILX-295501 at doses ranging from 100 to 1800 mg/m(2). The incidences of dose-limiting toxicity, principally neutropenia and thrombocytopenia, were unacceptably high at ILX-295501 doses exceeding 1000 mg/m(2), which was determined to be the MTD for both minimally pretreated and heavily pretreated (HP) patients. In contrast to the first generation of DSUs, particularly sulofenur, clinically relevant levels of oxidized hemoglobin (methemoglobin) and secondary hemolytic anemia, were not noted. One HP patient with non-small cell lung carcinoma experienced a partial response. Pharmacokinetic studies revealed that ILX-295501 was absorbed slowly, with peak plasma concentrations (C(max)) achieving 6.02 h, on average, after oral administration. The pharmacokinetic behavior of ILX-295501 was characterized by dose proportionality, a relatively small apparent volume of distribution at steady state (V(ss)/F), averaging 8.02 +/- 14.08 liters, and low apparent total body clearance (CL(t)/F) rate (mean, 0.036 +/- 0.116 liters/h). The initial drug distribution phase was rapid [harmonic mean half-life (t(1/2alpha)), 2.1 +/- 7.0 min], whereas the terminal elimination phase was slow (harmonic mean t(1/2beta,) 150.6 +/- 80.2 h).


CONCLUSIONS
The recommended dose for Phase II studies of the oral DSU ILX-295501 administered weekly for 3 weeks every 4 weeks is 1000 mg/m(2)/day for both minimally pretreated and HP patients. The characteristics of the myelosuppressive effects of ILX-295501, the paucity of severe nonhematological toxicities, and preliminary antitumor activity warrant disease-directed evaluations of ILX-295501.
Meta-analytic evidence for effects of mindfulness training on dimensions of self-reported dispositional mindfulness.

Improvements in stable, or dispositional, mindfulness are often assumed to accrue from mindfulness training and to account for many of its beneficial effects. However, research examining these assumptions has produced mixed findings, and the relation between dispositional mindfulness and mindfulness training is actively debated. A comprehensive meta-analysis was conducted on randomized controlled trials (RCTs) of mindfulness training published from 2003-2014 to investigate whether (a) different self-reported mindfulness scale dimensions change as a result of mindfulness training, (b) key aspects of study design (e.g., control condition type, population type, and intervention type) moderate training-related changes in dispositional mindfulness scale dimensions, and (c) changes in mindfulness scale dimensions are associated with beneficial changes in mental health outcomes. Scales from widely used dispositional mindfulness measures were combined into 5 categories for analysis: Attention, Description, Nonjudgment, Nonreactivity, and Observation. A total of 88 studies (n = 5,787) were included. Changes in scale dimensions of mindfulness from pre to post mindfulness training produced mean difference effect sizes ranging from small to moderate (g = 0.28-0.49). Consistent with the theorized role of improvements in mindfulness in training outcomes, changes in dispositional mindfulness scale dimensions were moderately correlated with beneficial intervention outcomes (r = .27-0.30), except for the Observation dimension (r = .16). Overall, moderation analyses revealed inconsistent results, and limitations of moderator analyses suggest important directions for future research. We discuss how the findings can inform the next generation of mindfulness assessment. (PsycINFO Database Record
The intergenerational transmission of intimate partner violence in Bangladesh

Background A number of individual risk factors for intimate partner violence (IPV) have been identified in Bangladesh. However, the etiology of IPV, intergenerational transmission, has never been tested in Bangladesh. Objective We examined whether witnessing inter-parental physical violence (IPPV) was associated with IPV to identify whether IPV passes across generations in Bangladesh. Methods We used nationally representative data of currently married women from the Bangladesh Demographic and Health Survey-2007. Variations in experiencing IPV were assessed by Chi-square tests. Logistic regression models were fit to determine the association between witnessing IPPV and different types of IPV against women. Results One-fourth of women witnessed IPPV and experienced IPV. After adjusting for the covariates, women who witnessed IPPV were 2.4 (95% confidence interval [CI]: 2.0-2.8) times more likely to experience any kind of IPV, 2.5 (95% CI: 2.0-3.0) times more likely to experience moderate physical IPV, 2.3 (95% CI: 1.8-3.0) times more likely to experience severe physical IPV, and 1.8 (95% CI: 1.4-2.3) times more likely to experience sexual IPV. Age, age at first marriage, literacy, work status, wealth, justified wife beating, and women's autonomy were also identified as significant correlates of IPV. Conclusions This study's results indicate that IPV passes from one generation to another. We make recommendations for preventing IPPV so that subsequent generations can enjoy healthy, respectful, nonviolent relationships in married life without exposure to IPV in Bangladesh.
Rapid Identification Authentication Protocol for Mobile Nodes in Internet of Things with Privacy Protection

Mobile nodes in the Internet of things often move from one cluster to another, in which cryptography based protocols are required to provide rapid identification authentication and privacy protection. A single-step protocol was presented for the occasion that the mobile node joins a new cluster. The presented protocol contains a valid request message and an answer authentication message, which rapidly implements identification authentication and privacy protection. The protocol’s privacy protection properties were formalized in the applied pi calculus and security performance was analyzed. It is concluded that the proposed protocol can resist replay attack, eavesdropping attack, and tracking or location privacy attack. It satisfies both untraceability and forward privacy these two privacy protection properties. Compared with other single-step protocols such as basic hash protocol and OSK protocol, the proposed protocol has less communication overhead, more security and more privacy protection properties over these related protocols.