LLukas22/scidocs huggingface dataset:
Effect of heavy strength training on thigh muscle cross-sectional area, performance determinants, and performance in well-trained cyclists

The purpose of this study was to investigate the effect of heavy strength training on thigh muscle cross-sectional area (CSA), determinants of cycling performance, and cycling performance in well-trained cyclists. Twenty well-trained cyclists were assigned to either usual endurance training combined with heavy strength training [E + S; n = 11 (♂ = 11)] or to usual endurance training only [E; n = 9 (♂ = 7, ♀ = 2)]. The strength training performed by E + S consisted of four lower body exercises [3 × 4–10 repetition maximum (RM)], which were performed twice a week for 12 weeks. Thigh muscle CSA, maximal force in isometric half squat, power output in 30 s Wingate test, maximal oxygen consumption (VO2max), power output at 2 mmol l−1 blood lactate concentration ([la−]), and performance, as mean power production, in a 40-min all-out trial were measured before and after the intervention. E + S increased thigh muscle CSA, maximal isometric force, and peak power in the Wingate test more than E. Power output at 2 mmol l−1 [la−] and mean power output in the 40-min all-out trial were improved in E + S (P < 0.05). For E, only performance in the 40-min all-out trial tended to improve (P = 0.057). The two groups showed similar increases in VO2max (P < 0.05). In conclusion, adding strength training to usual endurance training improved determinants of cycling performance as well as performance in well-trained cyclists. Of particular note is that the added strength training increased thigh muscle CSA without causing an increase in body mass.
Five questions predicted long-term, severe, back-related functional limitations: evidence from three large prospective studies.

OBJECTIVES
The objectives of the study were as follows: (1) to investigate whether the predictive validity of a previously developed back pain prediction rule could be improved; (2) to determine if the rule can be shortened without loss of predictive validity; (3) to compare the rule with the physician's judgment; (4) to assess, in a different population, its 2-year predictive validity; and (5) to evaluate the clinical applicability of the rule in a first-line care setting.


STUDY DESIGN AND SETTING
One thousand two hundred and sixty-two participants were enrolled in the study (participation: 91%) before a medical consultation for nonspecific back pain in a large emergency room and were followed up for 2 years (follow-up: 92.5%). The effects of adding new items and deleting any one of the original items were evaluated. The predictions by the rule and the physicians were compared with the 2-year actual functional limitations (measured with the Roland-Morris Disability Questionnaire).


RESULTS
Although the final prediction rule included only five items (feeling everything is an effort, trouble getting breath, hot/cold spells, numbness/tingling in parts of body, and pain in heart/chest), its predictive validity was greater than that of the original 17-item version and was superior to the physician's prediction. The rule was easily applied.


CONCLUSION
A five-item clinical prediction rule of long-term back-related functional limitations could help first-line care physicians to concentrate the clinical attention on patients at higher risk.
Step-cut distal ulnar-shortening osteotomy.

PURPOSE
Several techniques for ulnar-shortening osteotomies have been described in recent years, reflecting the difficulties that sometimes are encountered in what seems to be a relatively simple procedure. We describe the use of a simple step-cut ulnar-shortening osteotomy stabilized with a lag screw and a palmarly placed 3.5-mm neutralization plate.


METHODS
Twenty-nine patients had the surgery. The indication was ulnar-impaction syndrome in 23 patients and symptomatic ulnar-plus variance secondary to trauma in 6 patients (4 with previous distal radius fractures, 2 with Essex-Lopresti injuries). The preoperative ulnar variance ranged from +1 mm to +6 mm.


RESULTS
The mean follow-up period was 34 months. All osteotomies healed uneventfully. The mean postoperative ulnar variance was +0.2 mm (range, -1 mm to +1.5 mm). Three patients had hardware removal.


CONCLUSIONS
The step-cut osteotomy resulted in solid union in all patients. It provides ample bone-to-bone contact and easier control of rotation, and no special instrumentation is necessary. Stable fixation permitted early mobilization of the wrist and palmar placement of the plate minimized the need for plate removal. This is a simple and effective technique for ulnar shortening.
The Effect of Physical Exercise After a Concussion: A Systematic Review and Meta-analysis.

BACKGROUND
Data evaluating the role of exercise in patients with a concussion are contradictory. Studies have reported improvement in the Post-Concussion Symptom Scale (PCSS) score, whereas others showed no effect on the PCSS score.


PURPOSE
To conduct a systematic review and meta-analysis on the role of physical exercise on different outcomes in patients with a concussion.


STUDY DESIGN
Systematic review and meta-analysis.


METHODS
A search of 5 databases from the earliest available date to September 30, 2016, and a hand search of a few articles were performed. Trial registries were reviewed, and authors of multiple studies were contacted to find additional published or unpublished studies. Randomized controlled trials (RCTs), cohort studies, and before and after (pre-post) studies evaluating the effect of physical exercise, compared with control, in patients with a concussion or mild traumatic brain injury were included.


RESULTS
The search generated 1096 studies. Of these, 14 studies (5 RCTs, 1 propensity score matching study, 3 cohort studies, and 5 before and after studies) met our inclusion criteria. Exercise significantly decreased the PCSS score (mean difference, -13.06; 95% CI, -16.57 to -9.55; P < .00001; I2 = 44%), percentage of patients with symptoms of a concussion (risk ratio, 0.74; 95% CI, 0.63 to 0.86; P = .0001; I2 = 0%), and days off work (17.7 days vs 32.2 days, respectively; P < .05) compared with control. Exercise improved the reaction time (standard mean difference, -0.43; 95% CI, -0.80 to -0.06; P = .02) component of the Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT) score without affecting the Balance Error Scoring System (BESS) score and neuropsychological parameters. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) scores were moderate for the PCSS, symptoms, ImPACT, BESS, and neuropsychological tests.


CONCLUSION
Physical exercise appears to improve the PCSS score and symptoms in patients with a concussion. A high-quality RCT evaluating different intensities of exercise at different time points, for different durations after a concussion, for different races/ethnicities, and for sex needs to be conducted to evaluate a clear effect of exercise in patients with a concussion.
Reliability and validity of the Turkish version of the Memorial Symptom Assessment Scale in cancer patients.

AIM
The Memorial Symptom Assessment Scale (MSAS) is a multidimensional tool developed to evaluate measure the prevalence, characteristics and distress of common symptoms related to cancer. A validated Turkish version has now become available. The aim of this study was to evaluate its reliability and validity.


METHODS
One hundred-twenty patients were included into this study. The MSAS, The Rotterdam Symptom Checklist (RSCL), and Karnofsky Performance Status Scale (KPSS) were used for data collection. Content and criterion validities were examined. Reliability analyses of the MSAS were performed using internal consistency reliability and test-retest reliability.


RESULTS
The most frequently reported symptom (90%) was problems with sexual interest or activity. Item-total correlations ranged between 0.03 and 0.64. There was a high correlation between total MSAS and the RSCL (r=0.875, p<0.01). The internal consistency reliabilities of subscales of the MSAS and total MSAS were moderately high, with Cronbach alpha coefficients ranging from 0.71 to 0.84. The MSAS's test - re-test reliability was 0.78.


CONCLUSION
The MSAS for cancer patients was determined to be a valid and reliable instrument for the use in the Turkish population. It is recommended that the MSAS-Turkish version can be used as a tool for comprehensive symptom assessment in planning nursing care for cancer patients.
Unsupervised Detection and Promotion of Authoritative Domains for Medical Queries in Web Search

Medical or Health related search queries constitute a significant portion of the total number of queries searched everyday on the web. For health queries, the authenticity or authoritativeness of search results is of utmost importance besides relevance. So far, research in automatic detection of authoritative sources on the web has mainly focused on a) link structure based approaches and b) supervised approaches for predicting trustworthiness. However, the aforementioned approaches have some inherent limitations. For example, several content farm and low quality sites artificially boost their link-based authority rankings by forming a syndicate of highly interlinked domains and content which is algorithmically hard to detect. Moreover, the number of positively labeled training samples available for learning trustworthiness is also limited when compared to the size of the web. In this paper, we propose a novel unsupervised approach to detect and promote authoritative domains in health segment using click-through data. We argue that standard IR metrics such as NDCG are relevance-centric and hence are not suitable for evaluating authority. We propose a new authority-centric evaluation metric based on side-by-side judgment of results. Using real world search query sets, we evaluate our approach both quantitatively and qualitatively and show that it succeeds in significantly improving the authoritativeness of results when compared to a standard web ranking baseline. ∗Corresponding Author
Increased risk of HIV-1 transmission in pregnancy: a prospective study among African HIV-1-serodiscordant couples.

BACKGROUND
Physiologic and behavioral changes during pregnancy may alter HIV-1 susceptibility and infectiousness. Prospective studies exploring pregnancy and HIV-1 acquisition risk in women have found inconsistent results. No study has explored the effect of pregnancy on HIV-1 transmission risk from HIV-1-infected women to male partners.


METHODS
In a prospective study of African HIV-1-serodiscordant couples, we evaluated the relationship between pregnancy and the risk of HIV-1 acquisition among women and HIV-1 transmission from women to men.


RESULTS
Three thousand three hundred and twenty-one HIV-1-serodiscordant couples were enrolled, 1085 (32.7%) with HIV-1 susceptible female partners and 2236 (67.3%) with susceptible male partners. HIV-1 incidence in women was 7.35 versus 3.01 per 100 person-years during pregnant and nonpregnant periods [hazard ratio 2.34, 95% confidence interval (CI) 1.33-4.09]. This effect was attenuated and not statistically significant after adjusting for sexual behavior and other confounding factors (adjusted hazard ratio 1.71, 95% CI 0.93-3.12). HIV-1 incidence in male partners of infected women was 3.46 versus 1.58 per 100 person-years when their partners were pregnant versus not pregnant (hazard ratio 2.31, 95% CI 1.22-4.39). This effect was not attenuated in adjusted analysis (adjusted hazard ratio 2.47, 95% CI 1.26-4.85).


CONCLUSION
HIV-1 risk increased two-fold during pregnancy. Elevated risk of HIV-1 acquisition in pregnant women appeared in part to be explained by behavioral and other factors. This is the first study to show that pregnancy increased the risk of female-to-male HIV-1 transmission, which may reflect biological changes of pregnancy that could increase HIV-1 infectiousness.
Labor-Friendly Corporate Practices: Is What is Good for Employees Good for Shareholders?

As corporate managers interact with nonshareholder stakeholders, potential tradeoffs emerge and questions arise as to how these interactions impact shareholder value. We argue that this shareholder–stakeholder debate is an important issue within the overall corporate governance and corporate policy domain and examine one such stakeholder group – employees – by studying labor-friendly corporate practices. We find that announcements of labor-friendly policies are associated with positive abnormal stock returns. Labor-friendly firms also outperform otherwise similar firms, both in terms of long-run stock market returns and operating results. In addition, we find that the probability and benefits of labor-friendliness increase with the demand for highly skilled labor. Our analysis of excess executive compensation suggests that top management derives no pecuniary benefits from labor-friendly practices. We interpret our results as consistent with a genuine concern for employees translating into higher productivity and profitability, which in turn facilitate value creation. It appears that the benefits of labor-friendly practices significantly outweigh the costs and that what is good for employees is good for shareholders.
Geometric Robustness of Deep Networks: Analysis and Improvement

Deep convolutional neural networks have been shown to be vulnerable to arbitrary geometric transformations. However, there is no systematic method to measure the invariance properties of deep networks to such transformations. We propose ManiFool as a simple yet scalable algorithm to measure the invariance of deep networks. In particular, our algorithm measures the robustness of deep networks to geometric transformations in a worst-case regime as they can be problematic for sensitive applications. Our extensive experimental results show that ManiFool can be used to measure the invariance of fairly complex networks on high dimensional datasets and these values can be used for analyzing the reasons for it. Furthermore, we build on ManiFool to propose a new adversarial training scheme and we show its effectiveness on improving the invariance properties of deep neural networks.1
A qualitative analysis of software security patterns

Software security, which has attracted the interest of the industrial and research community during the last years, aims at preventing security problems by building software without the so-called security holes. One way to achieve this goal is to apply specific patterns in software architecture. In the same way that the well-known design patterns for building well-structured software have been defined, a new kind of patterns called security patterns have emerged. These patterns enable us to incorporate a level of security already at the design phase of a software system. There exists no strict set of rules that can be followed in order to develop secure software. However, a number of guidelines have already appeared in the literature. Furthermore, the key problems in building secure software and major threat categories for a software system have been identified. An attempt to evaluate known security patterns based on how well they follow each principle, how well they encounter with possible problems in building secure software and for which of the threat categories they do take care of, is performed in this paper. Thirteen security patterns were evaluated based on these three sets of criteria. The ability of some of these patterns to enhance the security of the design of a software system is also examined by an illustrative example of fortifying a published design. a 2006 Elsevier Ltd. All rights reserved.
Efficacy of salmeterol xinafoate in the treatment of COPD.

STUDY OBJECTIVES
To examine and compare the efficacy and safety of salmeterol xinafoate, a long-acting inhaled beta2-adrenergic agonist, with inhaled ipratropium bromide and inhaled placebo in patients with COPD.


DESIGN
A stratified, randomized, double-blind, double-dummy, placebo-controlled, parallel group clinical trial.


SETTING
Multiple sites at clinics and university medical centers throughout the United States.


PATIENTS
Four hundred eleven symptomatic patients with COPD with FEV1 < or = 65% predicted and no clinically significant concurrent disease.


INTERVENTIONS
Comparison of inhaled salmeterol (42 microg twice daily), inhaled ipratropium bromide (36 microg four times a day), and inhaled placebo (2 puffs four times a day) over 12 weeks.


RESULTS
Salmeterol xinafoate was significantly (p < 0.0001) better than placebo and ipratropium in improving lung function at the recommended doses over the 12-week trial. Both salmeterol and ipratropium reduced dyspnea related to activities of daily living compared with placebo; this improvement was associated with reduced use of supplemental albuterol. Analyses of time to first COPD exacerbation revealed salmeterol to be superior to placebo and ipratropium (p < 0.05). Adverse effects were similar among the three treatments.


CONCLUSIONS
These collective data support the use of salmeterol as first-line bronchodilator therapy for the long-term treatment of airflow obstruction in patients with COPD.
Qualitative exploration of a client-centered, goal-directed approach to community-based occupational therapy for adults with traumatic brain injury.

OBJECTIVES
We explored the clinical application of goal-directed therapy in community-based rehabilitation from the perspective of clients with traumatic brain injury (TBI), their significant others, and their treating occupational therapists.


METHOD
Twelve people with TBI and their significant others completed an outpatient, goal-directed, 12-week occupational therapy program. Semistructured interviews with 12 participants, 10 significant others, and 3 occupational therapists involved in delivering the therapy programs explored their experiences of goal-directed therapy.


RESULTS
Participants, their significant others, and therapists described goal-directed therapy positively, expressing satisfaction with progress made.


CONCLUSION
Goals provide structure, which facilitates participation in rehabilitation despite the presence of barriers, including reduced motivation and impaired self-awareness. A therapist-facilitated, structured, goal-setting process in which the client, therapist, and significant others work in partnership can enhance the process of goal setting and goal-directed rehabilitation in a community rehabilitation context.
Cheese analogues: a review

Cheese analogues are usually defined as products made by blending individual constituents, including non-dairy fats or proteins, to produce a cheese-like product to meet specific requirements. They are being used increasingly due to their cost-effectiveness, attributable to the simplicity of their manufacture and the replacement of selected milk ingredients by cheaper vegetable products. Sales of cheese analogues are closely linked to developments in the convenience food sector, where they extend the supply and lower the cost. Moreover, there is an ever-increasing interest among consumers in food products which contain less total fat, saturated fat, cholesterol, and calories. Development of cheese analogues involves the use of fat and/or protein sources other than those native to milk, together with a flavour system simulating as closely as possible that of the natural product. It is also necessary to develop a suitable processing regime capable of combining these elements to provide the required textural and functional properties. Cheese analogues may be regarded as engineered products. Cheese analogues represent little threat to the continued consumption of natural cheeses: Their major role at present is undoubtedly in the cost-cutting exercises of pizza manufacturers. The dairy industry has to take the view that imitation products are the result of developments in product technology and market demand. Thus not to get involved would mean curtailment of product innovation and market opportunities. r 2001 Elsevier Science Ltd. All rights reserved.
Preoperative plasma plasminogen activator inhibitor type-1 and serum C-reactive protein levels in patients with colorectal cancer. The RANX05 Colorectal Cancer Study Group.

BACKGROUND
Preoperative plasma plasminogen activator inhibitor-1 (PAI-1) is a prognostic variable in patients with colorectal cancer. It has been suggested, however, that plasma PAI-1 is a nonspecific prognostic parameter similar to the acute-phase reactant C-reactive protein (CRP). In the present study we analyzed the association between plasma PAI-1 and serum CRP in patients scheduled for elective resection of colorectal cancer. In addition, the prognostic value of PAI-1 and CRP was studied in this patient cohort.


METHODS
PAI-1 and CRP were analyzed in citrated plasma and serum, respectively, obtained preoperatively from 594 patients. Patients who required preoperative blood transfusion received SAGM blood, in which soluble PAI-1 is not present. None of the patients received pre- or postoperative adjuvant chemotherapy, and all were followed in the outpatient clinic for at least 5 years or until death. The association of PAI-1 and CRP, respectively, with survival was tested using the median value of PAI-1 and the upper normal limit for CRP. Analyses were performed by inclusion of all patients, and in the subgroup of patients, who underwent curative resection.


RESULTS
The median follow-up period was 6.8 (5.4-7.9) years. The median value of plasma PAI-1 was 35.8 ng/ml, and values greater than 94 nmol/L identified patients with increased CRP levels. Comparison of the molecules showed that PAI-1 was weakly correlated with CRP (r = .26; P <.0001). Both molecules showed a Dukes independent distribution. In univariate survival analyses high levels of PAI-1 were found associated with poor prognosis and low levels with good prognosis (P = .02, HR: 1.3). Similarly, high levels of CRP were found associated with poor prognosis and low levels with good prognosis (P <.0001, HR: 1.9). In a multivariate statistical analysis including Dukes classification, gender, age, tumor location, perioperative blood transfusion, PAI-1 and CRP, plasma PAI-1 was a dependent prognostic variable, while serum CRP (P <.0001; HR: 1.4; 95% CI: 1.3-1.5) was found to be a Dukes independent prognostic variable. Similar analyses, excluding patients with Dukes' D disease showed serum CRP to be an independent prognostic variable (P <.0001; HR: 1.3: 95% CI: 1.2-1.5).


CONCLUSIONS
This study did not show a strong correlation between plasma PAI-1 and serum CRP in patients with colorectal cancer. Serum CRP was found to be a Dukes independent prognostic variable in this patient cohort, and was found to identify a subgroup of curatively resected patients at risk for short survival.
Does hotel attribute importance differ by hotel? Focusing on hotel star-classifications and customers' overall ratings

Hotel guests’ expectations and actual experiences on hotel service quality often fail to coincide due to guests’ unusually high anticipations, hotels’ complete breakdowns in delivering their standard, or the combination of both. Moreover, this disconfirmation could be augmented contingent upon the level of hotel segment (hotel star-classification) and the overall rating manifested by previous guests. By incorporating a 2 2 matrix design in which a hotel star-classification configures one dimension (2 versus 4 stars) and a customers’ overall rating (lower versus higher overall ratings) configures the other, this explorative multiple case study uses conjoint analyses to examine the differences in the comparative importance of the six hotel attributes (value, location, sleep quality, rooms, cleanliness, and service) among four prominent hotel chain brands located in the United States. Four major and eight minor propositions are suggested for future empirical research based on the results of the four combined studies. Through the analysis of online data, this study may enlighten hotel managers with various ways to accommodate hotel guests’ needs. 2015 Elsevier Ltd. All rights reserved.