LLukas22/scidocs huggingface dataset:
Introduction to Decoherence Theory

This is an introduction to the theory of decoherence with an emphasis on its microscopic origins and its dynamic description. It is based on a lecture course given at the "International summer school on quantum information", Dresden. To appear in: Lecture Notes in Physics, Theoretical Foundations of Quantum Information, edited by A. Buchleitner and C. Viviescas.
Decentralized and centralized model predictive control to reduce the bullwhip effect in supply chain management

Mitigating the bullwhip effect is one of crucial problems in supply chain management. In this research, centralized and decentralized model predictive control strategies are applied to control inventory positions and to reduce the bullwhip effect in a benchmark four-echelon supply chain. The supply chain under consideration is described by discrete dynamic models characterized by balance equations on product and information flows with an ordering policy serving as the control schemes. In the decentralized control strategy, a MPC-EPSAC (Extended Prediction Self-Adaptive Control) approach is used to predict the changes in the inventory position levels. A closed-form solution of an optimal ordering decision for each echelon is obtained by locally minimizing a cost function, which consists of the errors between predicted inventory position levels and their setpoints, and a weighting function that penalizes orders. The single model predictive controller used in centralized control strategy optimizes globally and finds an optimal ordering policy for each echelon. The controller relies on a linear discrete-time state-space model to predict system outputs. But the predictions are approached by either of two multi-step predictors depending on whether the states of the controller model are directly observed or not. The objective function takes a quadratic form and thus the resulting optimization problem can be solved via standard quadratic programming method. The comparisons on performances of the two MPC strategies are illustrated with a numerical example. 2014 Elsevier Ltd. All rights reserved.
A Quantitative Histochemical Study of Alkaline Phosphatase Activity in Isolated Rat Duodenal Epithelial Cells

A simple separation method enabling the quantification of alkaline phosphatase activity in unfixed, isolated, individual, duodenal epithelial cells has been presented. The activity of intestinal brush border-bound alkaline phosphatase has been demonstrated using naphthol AS-BI phosphate as a substrate and hexazotized New Fuchsin as a simultaneous coupling agent. The amount of final reaction product, as measured cytophotometrically, increases linearly with incubation time (up to 10 min) and with substrate concentration (up to 0.4 mM). Maximum enzyme activity was obtained at pH 8.9. Variation of the substrate concentration revealed the kinetic parameters for naphthol AS-BI phosphate as Km = 0.17 ± 0.015 and Vmax = 13.9 ± 1.38. The specificity of the enzyme reaction was confirmed by the complete inhibition of the enzyme activity in the presence of l-cysteine (10 mm) and 80% inhibition with L - phenylalanine (30 mM). Comparison of alkaline phosphatase activity in 8-μm cryostat sections (beginning at the tip and proceeding to the cryptal part) along the villus axis, with the activity of individual cells obtained by successive separation, revealed similar values of the percentage quotient derived from the entire activities in these two different methods. This suggests that the presented separation procedure gives rise to isolation of the respective cells from the corresponding areas of the villus. Finally, the isolated cells can be used as a valuable tool for the quantitative analysis of alkaline phosphatase activity along the length of the villus.
Artistic QR Code Embellishment

A QR code is a two-dimensional barcode that encodes information. A standard QR code contains only regular black and white squares, and thus is unattractive. This paper proposes a novel framework for embellishing a standard QR code, to make it both attractive and recognizable by any human while maintaining its scanability. The proposed method is inspired by artistic methods. A QR code is typically embellished by stylizing the squares and embedding images into it. In the proposed framework, the regular squares are reshaped using a binary examplar, to make their local appearances resemble the example shape. Additionally, an error-aware warping technique for deforming the embedded image is proposed; it minimizes the error in the QR code that is generated by the embedding of the image to optimize the readability of the code. The proposed algorithm yields lower data error than previous global transformation techniques because the warping can locally deform the embedded image to conform to the squares that surround it. The proposed framework was examined by using it to embellish an extensive set of QR codes and to test the readability with various commercial QR code readers.
Solida: A Blockchain Protocol Based on Reconfigurable Byzantine Consensus

The decentralized cryptocurrency Bitcoin has experienced great success but also encountered many challenges. One of the challenges has been the long confirmation time. Another challenge is the lack of incentives at certain steps of the protocol, raising concerns for transaction withholding, selfish mining, etc. To address these challenges, we propose Solida, a decentralized blockchain protocol based on reconfigurable Byzantine consensus augmented by proof-of-work. Solida improves on Bitcoin in confirmation time, and provides safety and liveness assuming the adversary control less than (roughly) one-third of the total mining power.
The specificity and accuracy of (111)In-hexavalent lactoside in estimating liver reserve and its threshold value for mortality in mice.

BACKGROUND & AIMS
The asialoglycoprotein receptor on hepatocyte membranes recognizes the galactose residues of glycoproteins. We investigated the specificity, accuracy and threshold value of asialoglycoprotein receptor imaging for estimating liver reserve via scintigraphy using (111)In-hexavalent lactoside in mouse models.


METHODS
(111)In-hexavalent lactoside scintigraphy for asialoglycoprotein receptor imaging was performed on groups of normal mice, orthotopic SK-HEP-1-bearing mice, subcutaneous HepG2-bearing mice, mice with 20-80% partial hepatectomy and mice with acute hepatitis induced by acetaminophen. Liver reserve was measured by relative liver uptake and compared with normal mice. Asialoglycoprotein receptor blockade was performed via an in vivo asialofetuin competitive binding assay.


RESULTS
A total of 73.64±7.11% of the injection dose accumulated in the normal liver tissue region, and radioactivity was barely detected in the hepatoma region. When asialoglycoprotein receptor was blocked using asialofetuin, less than 0.41±0.04% of the injection dose was detected as background in the liver. Asialoglycoprotein receptor imaging data revealed a linear correlation between (111)In-hexavalent lactoside binding and residual liver mass (R(2)=0.8548) in 20-80% of partially hepatectomized mice, demonstrating the accuracy of (111)In-hexavalent lactoside imaging for measuring the functional liver mass. Asialoglycoprotein receptor imaging data in mice with liver failure induced using 600mg/kg acetaminophen revealed 19-45% liver reserve relative to normal mice and a fatal threshold value of 25% liver reserve.


CONCLUSION
The (111)In-hexavalent lactoside imaging method appears to be a good, specific, visual and quantitative predictor of functional liver reserve. The diagnostic threshold for survival was at 25% liver reserve in mice.
Choosing Futures: Influence of Ethnic Origin in University Choice.

Purpose – This paper aims to determine the role of ethnic origin on university application among Leicester college students.Design/methodology/approach – The approach takes the form of a quantitative survey of 427 students in sixth form colleges in Leicester.Findings – Five distinct motivational factors were derived from a survey of 427 sixth form college students in Leicester (UK). For all ethnic groups, the student's career is the most important motivating factor; the other motivators are, however, more varied. The influence of the family was most important among Pakistani and African students. Indian and “other” Asian students were most strongly associated with academic and social motivators. White applicants, on the other hand, had no relative strengths with regard to common motivators. What was perhaps more apparent was how unimportant family was on influencing choice. There were also differences between the ethnic groups and the university type applied for. While Afro‐Caribbeans had 100 per cent acc...
Effect of a 72 Hour Stroke Care Bundle on Early Outcomes after Acute Stroke: A Non Randomised Controlled Study

BACKGROUND
Integrated care pathways (ICP) in stroke management are increasingly being implemented to improve outcomes of acute stroke patients. We evaluated the effect of implementing a 72 hour stroke care bundle on early outcomes among patients admitted within seven days post stroke to the national referral hospital in Uganda.


METHODS
In a one year non-randomised controlled study, 127 stroke patients who had 'usual care' (control group) were compared to 127 stroke patients who received selected elements from an ICP (intervention group). Patients were consecutively enrolled (controls first, intervention group second) into each group over 5 month periods and followed to 30-days post stroke. Incidence outcomes (mortality and functional ability) were compared using chi square test and adjusted for potential confounders. Kaplan Meier survival estimates and log rank test for comparison were used for time to death analysis for all strokes and by stroke severity categories. Secondary outcomes were in-hospital mortality, median survival time and median length of hospital stay.


RESULTS
Mortality within 7 days was higher in the intervention group compared to controls (RR 13.1, 95% CI 3.3-52.9). There was no difference in 30-day mortality between the two groups (RR 1.2, 95% CI 0.5-2.6). There was better 30-day survival in patients with severe stroke in the intervention group compared to controls (P = 0.018). The median survival time was 30 days (IQR 29-30 days) in the control group and 30 days (IQR 7-30 days) in the intervention group. In the intervention group, 41patients (32.3%) died in hospital compared to 23 (18.1%) in controls (P < 0.001). The median length of hospital stay was 8 days (IQR 5-12 days) in the controls and 4 days (IQR 2-7 days) in the intervention group. There was no difference in functional outcomes between the groups (RR 0.9, 95% CI 0.4-2.2).


CONCLUSIONS
While implementing elements of a stroke-focused ICP in a Ugandan national referral hospital appeared to have little overall benefit in mortality and functioning, patients with severe stroke may benefit on selected outcomes. More research is needed to better understand how and when stroke protocols should be implemented in sub-Saharan African settings.


TRIAL REGISTRATION
Pan African Clinical Trials Registry PACTR201510001272347.
Cost Effectiveness of Entecavir versus Lamivudine with Adefovir Salvage in HBeAg-Positive Chronic Hepatitis B

Objective: To evaluate the cost effectiveness of treatment of hepatitis B e antigen (HBeAg)-positive chronic hepatitis B (CHB) with entecavir compared with lamivudine with adefovir salvage, based primarily on the results of a recent 2-year, randomised, multicentre, clinical trial (n = 709). Previous economic analyses have been limited by the lack of comparative clinical data for entecavir and lamivudine beyond 1-year duration and for salvage therapy. Methods: We conducted a cost-utility analysis using a Markov model from a USpayer perspective over a lifetime time horizon. The hypothetical cohort was 35-year-old patients with HBeAg-positive CHB. We evaluated 2 years of treatment with entecavir 0.5mg/day versus lamivudine 100mg/day, plus addition of adefovir 10mg/day for patients who developed virologic breakthrough due to resistance to either drug. In a scenario analysis, we considered adefovir plus lamivudine combination therapy for treatment-naive patients. Clinical and economic inputs ($US, year 2006 values) were derived from publicly available data, and probabilistic sensitivity analyses were conducted to evaluate uncertainty in the results. Results: The estimated 10-year cumulative incidence of cirrhosis for patients initiated on entecavir was 2.3% lower than for those on lamivudine (20.5% vs 22.8%). The discounted incremental cost per QALY gained was $US7600 in the base-case analysis, and the 95% central range from probabilistic sensitivity analysis was $US2500–$US19 100. Combination therapy for treatment-naive patients led to an increase in costs without improvement in patient outcomes compared with entecavir monotherapy. Conclusions: Our analysis suggests entecavir improves health outcomes in a cost-effective manner compared with lamivudine with adefovir salvage or combination therapy, and highlights the importance of using evidence-based effectiveness estimates in economic studies of CHB therapies.
Effects of Classroom Seating Arrangements on Children's question-asking

This study investigated the relationship between classroom seating arrangements and the question-asking of fourth-graders. Data were collected during 53 lessons spread over 8 weeks. Children were assigned to sit in a semicircle and then in a row-and-column seating arrangement for 2 weeks each. This rotation was repeated. Both children’s questions and the teacher’s verbal reactions were recorded using an observational system based on Kearsley’s question taxonomy. The results showed that children asked more questions in the semicircle than in the row-and-column arrangement, and that the pattern of question characteristics was stable over time. The findings also revealed that, within the row-and-column arrangement, there was an actionzone in which children asked more questions per lesson. The results are interpreted in terms of Steinzor’s postulation that social interaction is encouraged when individuals are able to establish face-to-face contact.
An unusual exit wound as a result of a shotgun suicide to the head.

The location of a gunshot entrance wound as well as the wound path trajectory are the main findings that help to determine the position from which a weapon was fired and thus distinguish firearm suicides from homicides and accidents. We present a case of a 28-year old man, who was found dead in his car. Because of an unusual position of the firearm, which was clamped into the steering wheel, and an unclear entrance/exit wound, an autopsy was performed. The deceased showed typical signs of a contact shotgun wound to the head with an entrance wound in the right temporal region and an exit wound in the midface. With the help of gunpowder attachments and a muzzle imprint at the entrance site, a wound channel from the right lower posterior part of the temporal region to the left anterior part of the mid-facial region could be reconstructed. The stellate wound in the midface was assessed as an atypical exit wound. The cause of death was a contact shotgun shot to the right temple with a consequent central regulatory failure due to extensive brain injury. The manner of death was concluded to be a suicide.
optCluster: An R Package for Determining the Optimal Clustering Algorithm

There exist numerous programs and packages that perform validation for a given clustering solution; however, clustering algorithms fare differently as judged by different validation measures. If more than one performance measure is used to evaluate multiple clustering partitions, an optimal result is often difficult to determine by visual inspection alone. This paper introduces optCluster, an R package that uses a single function to simultaneously compare numerous clustering partitions (created by different algorithms and/or numbers of clusters) and obtain a "best" option for a given dataset. The method of weighted rank aggregation is utilized by this package to objectively aggregate various performance measure scores, thereby taking away the guesswork that often follows a visual inspection of cluster results. The optCluster package contains biological validation measures as well as clustering algorithms developed specifically for RNA sequencing data, making it a useful tool for clustering genomic data.


AVAILABILITY
This package is available for free through the Comprehensive R Archive Network (CRAN) at http://cran.rproject.org/web/packages/optCluster/.
Cyberbullying: The hidden side of college students

The purpose of this study was to investigate how university students perceive their involvement in the cyberbullying phenomenon, and its impact on their well-being. Thus, this study presents a preliminary approach of how college students’ perceived involvement in acts of cyberbullying can be measured. Firstly, Exploratory Factor Analysis (N = 349) revealed a unidimensional structure of the four scales included in the Cyberbullying Inventory for College Students. Then, Item Response Theory (N = 170) was used to analyze the unidimensionality of each scale and the interactions between participants and items. Results revealed good item reliability and Cronbach’s a for each scale. Results also showed the potential of the instrument and how college students underrated their involvement in acts of cyberbullying. Additionally, aggression types, coping strategies and sources of help to deal with cyberbullying were identified and discussed. Lastly, age, gender and course-related issues were considered in the analysis. Implications for researchers and practitioners are discussed. 2014 Elsevier Ltd. All rights reserved.
Tooth extraction in patients receiving oral or intravenous bisphosphonate administration: A trigger for BRONJ development?

INTRODUCTION
Scientific debate outlines tooth extraction as a potential trigger for the onset of bisphosphonate-related osteonecrosis of the jaw (BRONJ). Therefore, the aim of this study was to investigate the outcome of tooth extractions in patients receiving bisphosphonate therapy.


PATIENTS AND METHODS
A retrospective cohort study was performed on patients with a history of oral or intravenous bisphosphonate administration and tooth extraction between 2007 and 2013 in a single university hospital oral and maxillofacial surgical unit. In all patients, extractions were performed according to the guidelines of the German Society of Oral and Maxillofacial Surgery. The outcome variable was the onset of typical BRONJ signs during postoperative follow-up.


RESULTS
In 72 subjects (53 female, 19 male; mean age 67.5 years) receiving oral (n = 27) and/or intravenous (n = 45) bisphosphonates due to malignant tumor (n = 43) or osteoporosis (n = 29), 216 tooth extractions were performed. The mean duration of intake was 36.2 months. In 67 out of 72 patients (93.1%) and 209 out of the 216 extraction sites the postoperative course was uneventful and the wounds healed without complications. Three of the 72 patients (4.2%) developed osteonecrosis of the jaw in four of the 216 extraction sites (1.9%). Duration and route of administration, oral hygiene and steroid intake were identified as potential risk factors for the development of BRONJ.


CONCLUSION
Tooth extraction in patients receiving bisphosphonates can be performed in a safe and predictable way, even in high-risk patients, when performed according to established guidelines. It is not tooth extractions themselves, but rather prevailing infectious conditions that may be a key risk factor for the development of BRONJ.
40 Gb/s analog IC chipset for optical receiver using SiGe HBTs

A preamplifier with 35 GHz bandwidth and 48.7 dB/spl Omega/ transimpedance gain, an automatic-gain-control (AGC) amplifier core with 31 GHz bandwidth, and a 40 Gb/s decision circuit are presented for future optical-transmission systems at a data rate of 40 Gb/s in global communication systems. A self-aligned selective-epitaxial SiGe-base heterojunction bipolar transistor is used to implement these circuits. This analog IC chipset meets the requirements for a 40 Gb/s optical receiver.
Wireless Hand Gesture Capture through Wearable Passive Tag Sensing

For wearable computing to become more widely accepted, the associated Human-Computer Interface must move past today's keyboard, keypad, touch screen, or other bulky hand-held interfaces to allow a user to specify input through their fingers without taking their eyes and attention off their immediate focus. Accordingly, we have developed a wearable system to track hand gestures with passive RFID sensor tags. This system is composed of an ultra-high frequency (UHF) reader and small, passive, finger-worn tags powered by transmit RF energy, each equipped with a variety of sensors that could be used to detect gestures. The primary physical goals of the system were to be comfortable and wearable without interfering with other everyday activities while tracking particular hand movements that could be used to control a wearable computer or aid in interaction with ubiquitous or other wearable devices. This paper first introduces our hardware, then gives some example user interface implementations, such as a mouse scrolled by hand position and a click specified by finger proximity, entering input by touching fingers, setting options when moving the hand to a particular spot of the user's apparel labeled with a passive RFID tag, and otherwise mapping control onto motion of the hand, arm, and fingers. The overall system was fully functional, but as this is an early implementation, it was still very much limited by transmit power and antenna efficiency, due to the constraints on the size of the passive tags. Means of scaling to lower power and smaller size are suggested.
The challenges and government responses to the ranks building of private entrepreneurs in Taizhou

This paper briefly reviews the important role of the private entrepreneurs in the local economic development in Taizhou, and then analyzes the challenges of the ranks building of the private entrepreneurs, and the role of team-building mechanism played by the local government. At last, some effective government measures are brought to promote the team building of private enterprises in Taizhou.