LLukas22/scidocs huggingface dataset:
Cognitive effects of topiramate revealed by standardised low-resolution brain electromagnetic tomography (sLORETA) of event-related potentials

OBJECTIVE
To evaluate the effect of topiramate (TPM) on event-related potentials (ERPs) in patients with epilepsy.


METHODS
Neuropsychological tests and ERP study using auditory oddball paradigm were conducted before and after treatment with TPM in drug-naive epilepsy patients. To detect target brain regions in which ERP changed during the cognitive task, cortical current densities of ERP components were analysed using standardised low-resolution electromagnetic tomography (sLORETA).


RESULTS
Neuropsychological tests (n=18 patients) showed that TPM significantly decreased the score in digit span, Corsi block and Controlled Oral Word Association word fluency. Repeated-measures analysis of variance of ERP data (n=13 patients) revealed that P2 amplitude was significantly increased at Fz electrode following treatment with TPM. Statistical non-parametric map of sLORETA between pre- and post-TPM ERPs revealed that current density of P200 component was significantly reduced by TPM in bilateral parieto-occipital, temporolimbic and dorsolateral right prefrontal regions.


CONCLUSIONS
Our findings suggest that TPM affects selective brain regions which may be related to cognitive side effects.


SIGNIFICANCE
Source localisation of ERPs can be helpful in identifying target brain regions for the cognitive side effects of anti-epileptic drugs.
The Evolutionary Origins of Mood and Its Disorders

The term 'mood' in its scientific usage refers to relatively enduring affective states that arise when negative or positive experience in one context or time period alters the individual's threshold for responding to potentially negative or positive events in subsequent contexts or time periods. The capacity for mood appears to be phylogenetically widespread and the mechanisms underlying it are highly conserved in diverse animals, suggesting it has an important adaptive function. In this review, we discuss how moods can be classified across species, and what the selective advantages of the capacity for mood are. Core moods can be localised within a two-dimensional continuous space, where one axis represents sensitivity to punishment or threat, and the other, sensitivity to reward. Depressed mood and anxious mood represent two different quadrants of this space. The adaptive function of mood is to integrate information about the recent state of the environment and current physical condition of the organism to fine-tune its decisions about the allocation of behavioural effort. Many empirical observations from both humans and non-human animals are consistent with this model. We discuss the implications of this adaptive approach to mood systems for mood disorders in humans.
Design of koch fractal bow tie antenna for wireless applications

The crowding of wireless band has necessitated the development of multiband and wideband wireless antennas. Because of the self similar characteristics, fractal concepts have emerged as a design methodology for compact multiband antennas. A Koch-like fractal curve is proposed to transform ultra-wideband (UWB) bow-tie into so called Koch-like sided fractal bow-tie dipole. A small isosceles triangle is cut off from center of each side of the initial isosceles triangle, then the procedure iterates along the sides like Koch curve does, forming the Koch-like fractal bow-tie geometry, used for multiband applications. ADS software is used to design the proposed antennna. It has covers the applications like GSM, wireless band and other wireless communications. Keywords—fractal; koch curve; bow tie antenna; ADS(Advanced Design System);
Hybrid Deposition Manufacturing : Design Strategies for Multimaterial Mechanisms Via Three-Dimensional Printing and Material Deposition

This paper describes a novel fabrication technique called hybrid deposition manufacturing (HDM), which combines additive manufacturing (AM) processes such as fused deposition manufacturing (FDM) with material deposition and embedded components to produce multimaterial parts and systems for robotics, mechatronics, and articulated mechanism applications. AM techniques are used to print both permanent components and sacrificial molds for deposited resins and inserted parts. Design strategies and practical techniques for developing these structures and molds are described, taking into account considerations such as printer resolution, build direction, and printed material strength. The strengths of interfaces between printed and deposited materials commonly used in the authors’ implementation of the process are measured to characterize the robustness of the resulting parts. The process is compared to previously documented layered manufacturing methodologies, and the authors present examples of systems produced with the process, including robot fingers, a multimaterial airless tire, and an articulated camera probe. This effort works toward simplifying fabrication and assembly complexity over comparable techniques, leveraging the benefits of AM, and expanding the range of design options for robotic mechanisms. [DOI: 10.1115/1.4029400]
A Performance Study of Monitoring and Information Services for Distributed Systems

Monitoring and information services form a key component of a distributed system, or Grid. A quantitative study of such services can aid in understanding the performance limitations, advise in the deployment of the systems, and help evaluate future development work. To this end, we study the performance of three monitoring and information services for distributed systems: the Globus Toolkit’s Monitoring and Discovery Service (MDS), the European Data Grid Relational Grid Monitoring Architecture (R-GMA) and Hawkeye, part of the Condor project. We perform experiments to test their scalability with respect to number of users, number of resources and amount of data collected. Our study shows that each approach has different behaviors, often due to their different design goals. In the four sets of experiments we conducted to evaluate the performance of the service components under different circumstances, we found a strong advantage to caching or prefetching the data, as well as the need to have primary components at well connected sites due to high load seen by all systems.
Comparison of the efficacy of aroma-acupressure and aromatherapy for the treatment of dementia-associated agitation

BACKGROUND
One of the most common symptoms observed in patients with dementia is agitation, and several non-pharmacological treatments have been used to control this symptom. However, because of limitations in research design, the benefit of non-pharmacological treatments has only been demonstrated in certain cases. The purpose of this study was to compare aroma-acupressure and aromatherapy with respect to their effects on agitation in patients with dementia.


METHODS
In this experimental study, the participants were randomly assigned to three groups: 56 patients were included in the aroma-acupressure group, 73 patients in the aromatherapy group, and 57 patients in the control group who received daily routine as usual without intervention. The Cohen-Mansfield Agitation Inventory (CMAI) scale and the heart rate variability (HRV) index were used to assess differences in agitation. The CMAI was used in the pre-test, post-test and post-three-week test, and the HRV was used in the pre-test, the post-test and the post-three-week test as well as every week during the four-week interventions.


RESULTS
The CMAI scores were significantly lower in the aroma-acupressure and aromatherapy groups compared with the control group in the post-test and post-three-week assessments. Sympathetic nervous activity was significantly lower in the fourth week in the aroma-acupressure group and in the second week in the aromatherapy group, whereas parasympathetic nervous activity increased from the second week to the fourth week in the aroma-acupressure group and in the fourth week in the aromatherapy group.


CONCLUSIONS
Aroma-acupressure had a greater effect than aromatherapy on agitation in patients with dementia. However, agitation was improved in both of the groups, which allowed the patients with dementia to become more relaxed. Future studies should continue to assess the benefits of aroma-acupressure and aromatherapy for the treatment of agitation in dementia patients.


TRIAL REGISTRATION
ChiCTR-TRC-14004810; Date of registration: 2014/6/12.
The normative imperatives of business and marketing strategy: grounding strategy in resource-advantage theory

Determining the strategic thrust of the firm, it may be argued, is the principal task of top management. This task is aided by recent theories of business and marketing strategy, including the normative imperatives based on industry factors, resource factors, competences, market orientation, and relationship marketing. Choosing wisely from among the various theories of strategy requires an accurate understanding of the contexts of competition. This article argues that resource-advantage theory, an evolutionary, disequilibrium-provoking process theory of competition, provides that understanding. That is, resource-advantage theory grounds theories of business and marketing strategy.
An Asian Origin of Virulent Aeromonas hydrophila Responsible for Disease Epidemics in United States-Farmed Catfish

UNLABELLED
Since 2009, catfish farming in the southeastern United States has been severely impacted by a highly virulent and clonal population of Aeromonas hydrophila causing motile Aeromonas septicemia (MAS) in catfish. The possible origin of this newly emerged highly virulent A. hydrophila strain is unknown. In this study, we show using whole-genome sequencing and comparative genomics that A. hydrophila isolates from diseased grass carp in China and catfish in the United States have highly similar genomes. Our phylogenomic analyses suggest that U.S. catfish isolates emerged from A. hydrophila populations of Asian origin. Furthermore, we identified an A. hydrophila strain isolated in 2004 from a diseased catfish in Mississippi, prior to the onset of the major epidemic outbreaks in Alabama starting in 2009, with genomic characteristics that are intermediate between those of the Asian and Alabama fish isolates. Investigation of A. hydrophila strain virulence demonstrated that the isolate from the U.S. catfish epidemic is significantly more virulent to both channel catfish and grass carp than is the Chinese carp isolate. This study implicates the importation of fish or fishery products into the United States as the source of highly virulent A. hydrophila that has caused severe epidemic outbreaks in United States-farmed catfish and further demonstrates the potential for invasive animal species to disseminate bacterial pathogens worldwide.


IMPORTANCE
Catfish aquaculture farming in the southeastern United States has been severely affected by the emergence of virulent Aeromonas hydrophila responsible for epidemic disease outbreaks, resulting in the death of over 10 million pounds of catfish. Because the origin of this newly emerged A. hydrophila strain is unknown, this study used a comparative genomics approach to conduct a phylogenomic analysis of A. hydrophila isolates obtained from the United States and Asia. Our results suggest that the virulent isolates from United States-farmed catfish have a recent common ancestor with A. hydrophila isolates from diseased Asian carp. We have also observed that an Asian carp isolate, like recent U.S. catfish isolates, is virulent in catfish. The results from this study suggest that the highly virulent U.S. epidemic isolates emerged from an Asian source and provide another example of the threat that invasive species pose in the dissemination of bacterial pathogens.
On the design of D2D synchronization in 3GPP Release-12

This document reviews the main design decisions that have been made for the physical layer design of the Device-to-Device (D2D) synchronization signals and channels as part of the 3GPP Release-12 specification work. The intention is to provide some context and background to the agreed design decisions because this rationale will not be described in the 3GPP specifications.
HANDEXOS : TOWARDS A SUPPORT DEVICE FOR HAND ACTIVITIES AND

HANDEXOS is an exoskeleton device for supporting th e human hand and performing teleoperation activities. It could be used to opera te both in remote-manipulation mode and directly in microgravity environments. In manipulation mode, crew or operators within the space ship could tele-control the endeffector of a robot in the space during the executi on of extravehicular activities (EVA) by means of an advanced upper limb exoskeleton. The ch oice of an appropriate man-machine interface (MMI) is important to allow a correct and dexterous grasp of objects of regular and irregular shapes in the space. Many different t chnologies have been proposed, from conventional joysticks to exoskeletons, but the ari sing number of more and more dexterous space manipulators such as Robonaut [1] or Eurobot [2] leads researchers to design novel MMIs with the aim to be more capable to exploit all functional advantages offered by new space robots. From this point of view exoskeletons better suite for execution of remote control-task than conventional joysticks, facilitat ing commanding of three dimensional trajectories and saving time in crew’s operation a nd training [3]. Moreover, it’s important to point out that in micro gravity environments the astronauts spend most time doing motor exercises, so HANDEXOS can be useful in supporting such motor practice, assisting human operators in overco ming physical limitations deriving from the fatigue in performing EVA. It is the goal of this paper to provide a detailed description of HANDEXOS mechanical design and to present the results of the preliminar y simulations derived from the implementation of the exoskeleton/human finger dyna mic model for different actuation solutions.
Phase I-II trial of weekly bicalutamide in men with elevated prostate-specific antigen and negative prostate biopsies.

BACKGROUND
Men with elevated prostate-specific antigen (PSA) and negative prostate biopsies are at risk for prostate cancer. The antiandrogen bicalutamide has a prolonged half-life, thus potentially allowing an intermittent administration to retain activity while reducing toxicity. We conducted a phase I-II trial of weekly bicalutamide in men with PSA >4 ng/mL and negative biopsies.


METHODS
Eighty subjects were nonrandomly assigned to a three-arm trial to either bicalutamide 50 mg/wk (n = 26) or 100 mg/wk (n = 28) or no treatment (n = 26) for 6 months. Blood samples were obtained at 0, 3, and 6 months, and prostate biopsies were repeated after 6 months. The outcome measures were 6-month changes of tissue Ki-67 (primary end point), high-grade prostatic intraepithelial neoplasia (HG-PIN), proliferative inflammatory atrophy, circulating PSA, and sex hormones.


RESULTS
Ki-67 expression was higher in HG-PIN than in normal tissue (10% versus 3%; P < 0.01) but was not modulated by bicalutamide in normal luminal cells. A trend toward an improvement of HG-PIN status was found in treated subjects (26% improved, 60% had no change, 15% worsened) as compared with the no-treatment arm (4% improved, 83% had no change, 13% worsened; P = 0.07). Proliferative inflammatory atrophy prevalence was not reduced by bicalutamide. Bicalutamide reduced PSA by 50% in both arms and raised testosterone and estradiol levels. Asymptomatic breast swelling was noted in 40% of the treated cases.


CONCLUSIONS
A weekly administration of bicalutamide seems to be reasonably safe and shows an encouraging signal of activity on HG-PIN prevalence, supporting further studies of this schedule in men at high risk despite the negative primary end-point findings on Ki-67.
Periodic motion planning for virtually constrained Euler-Lagrange systems

The paper suggests an explicit form of a general integral of motion for some classes of dynamical systems including n-degrees of freedom Euler–Lagrange systems subject to (n − 1) virtual holonomic constraints. The knowledge of this integral allows to extend the classical results due to Lyapunov for detecting a presence of periodic solutions for a family of second order systems, and allows to solve the periodic motion planning task for underactuated Euler–Lagrange systems, when there is only one not directly actuated generalized coordinate. As an illustrative example, we have shown how to create a periodic oscillation of the pendulum for a cart–pendulum system and how then to make them orbitally exponentially stable following the machinery developed in [A. Shiriaev, J. Perram, C. Canudas-de-Wit, Constructive tool for an orbital stabilization of underactuated nonlinear systems: virtual constraint approach, IEEE Trans. Automat. Control 50 (8) (2005) 1164–1176]. The extension here also considers time-varying virtual constraints. © 2006 Elsevier B.V. All rights reserved.
Sketch-Based SIP Flooding Detection Using Hellinger Distance

The Voice over IP (VoIP) application utilizes the Internet to provide voice service; thus it is susceptible to various security issues common on the IP networks, such as the flooding attack. Moreover, VoIP uses the Session Initiation Protocol (SIP) for session control and management. The transactional nature of SIP makes flooding attack an even severer threat, which can consequentially lead to denial of service (DoS). In this paper, we develop an efficient online SIP flooding detection scheme by integrating the sketch technique with Hellinger distance (HD) based detection. The sketch data structure can summarize the SIP call generating process into a fixed set of data for developing a probability model. The HD technique, combined with on-line traffic estimation, can efficiently identify attacks by monitoring the distance between current traffic distribution and the estimated distribution based on history information. Compared to the original HD detection system, our technique achieves the advantages of higher accuracy, flexibility to deal with multi-attribute attacks and DDoS attacks, and the ability to track the period of attack. Computer simulation results are presented to demonstrate the performance of the proposed technique.
Prefix-Randomized Query-Tree Protocol for RFID Systems

In this paper we present a new tree search-based protocol for the anti-collision problem of RFID systems. This protocol builds a binary search tree according to the prefixes chosen randomly by tags rather than using their ID-based prefixes. Therefore, the tag identification time of the proposed protocol is no longer limited by the tag ID distribution and ID length as the conventional tree search protocol. The time complexity of the protocol is derived and shown that it can identify tags faster than the Query-Tree protocol.
An Algorithmic Proof of Suslin′s Stability Theorem for Polynomial Rings

Let k be a field. Then Gaussian elimination over k and the Euclidean division algorithm for the univariate polynomial ring k[x] allow us to write any matrix in SLn(k) or SLn(k[x]), n ≥ 2, as a product of elementary matrices. Suslin’s stability theorem states that the same is true for the multivariate polynomial ring SLn(k[x1, . . . , xm]) with n ≥ 3. As Gaussian elimination gives us an algorithmic way of finding an explicit factorization of the given matrix into elementary matrices over a field, we develop a similar algorithm over polynomial rings.
The Effects of Sprint Interval vs. Continuous Endurance Training on Physiological And Metabolic Adaptations in Young Healthy Adults

The purpose of this study was to compare the effects of sprint interval training (SIT) and continuous endurance training (CET) on selected anthropometric, aerobic, and anaerobic performance indices as well as the blood lipid profile, inflammatory and muscle damage markers in healthy young males. Fifteen recreationally active male volunteers (age: 21.7 ±2.2 years, body mass: 83.0 ±8.0 kg, body height: 1.82 ±0.05 m) were divided into two groups according to their initial VO2max levels. Training programs were conducted 3 times per week for 7 weeks. The SIT program consisted of 4-6 Wingate anaerobic sprints with a 4.5 min recovery, while CET consisted of 30-50 min cycling at 60% VO2max. Biochemical, anthropometric and fitness assessments were performed both pre and post-intervention. Significant improvements in VO2max, anaerobic power and capacity, and VO2 utilization during the submaximal workout and significant decreases in body fat and in waist circumference after the intervention occurred in both SIT and CET groups. Significantly greater gross efficiency was measured in the CET group. No differences in the lipid profile or serum levels of inflammatory, myocardial and skeletal muscle damage markers were observed after the training period. The study results agree with the effectiveness of a 30 s all-out training program with a reduced time commitment for anthropometric, aerobic and anaerobic adaptation and eliminate doubts about its safety as a model.
Cellular automata for real-time generation of infinite cave levels

This paper presents a reliable and efficient approach to procedurally generating level maps based on the self-organization capabilities of cellular automata (CA). A simple CA-based algorithm is evaluated on an infinite cave game, generating playable and well-designed tunnel-based maps. The algorithm has very low computational cost, permitting realtime content generation, and the proposed map representation provides sufficient flexibility with respect to level design.
Moving from customer lifetime value to customer equity

We study the consequence of moving from Customer Lifetime Value maximization to Customer Equity maximization. Customer equity has traditionally been seen as the discounted sum of the lifetime earnings from all current and future customers and thus it has been largely assumed that maximizing customer lifetime value would lead to maximum customer equity. We show that the transition from CLV to CE is not that straightforward. Although the CLV model is appropriate for managing a single non-replaceable customer, the application of a CLV model to the acquisition and valuation of customers as an ongoing concern for the firm leads to sub-optimal customer relationship management and acquisition strategies. This leads the firm following a CLV maximization approach to have a smaller and less profitable customer base than one that follows a CE maximization strategy.
The use of engineering documentation in support of a high density logic test system

Introduction of System 360 placed unprecedented technical demands on all IBM facilities. This paper describes the application of Engineering Design Automation Information in support of the development and implementation of a manufacturing test data system.
Understanding Referring Expressions in Situated Language Some Challenges for Real-World Agents Donna

Past research efforts to construct embodied conversational agents have focused on features of multi-channel communication that are made possible by embodiment. This paper draws attention instead to 4 crucial aspects of the linguistic forms that an embodied agent will encounter, and that language understanding agents must master in order to converse and collaborate with humans in the real world. If language technology is to be ready to support conversation in the copresent technologies that will soon arrive, these deficiencies in linguistic competence must be addressed now.