LLukas22/scidocs huggingface dataset:
Interstitial solute transport in 3D reconstructed neuropil occurs by diffusion rather than bulk flow.

The brain lacks lymph vessels and must rely on other mechanisms for clearance of waste products, including amyloid [Formula: see text] that may form pathological aggregates if not effectively cleared. It has been proposed that flow of interstitial fluid through the brain's interstitial space provides a mechanism for waste clearance. Here we compute the permeability and simulate pressure-mediated bulk flow through 3D electron microscope (EM) reconstructions of interstitial space. The space was divided into sheets (i.e., space between two parallel membranes) and tunnels (where three or more membranes meet). Simulation results indicate that even for larger extracellular volume fractions than what is reported for sleep and for geometries with a high tunnel volume fraction, the permeability was too low to allow for any substantial bulk flow at physiological hydrostatic pressure gradients. For two different geometries with the same extracellular volume fraction the geometry with the most tunnel volume had [Formula: see text] higher permeability, but the bulk flow was still insignificant. These simulation results suggest that even large molecule solutes would be more easily cleared from the brain interstitium by diffusion than by bulk flow. Thus, diffusion within the interstitial space combined with advection along vessels is likely to substitute for the lymphatic drainage system in other organs.
Improved accuracy in estimation of left ventricular function parameters from QGS software with Tc-99m tetrofosmin gated-SPECT: a multivariate analysis.

UNLABELLED
The purpose of this study was to verify whether the accuracy of left ventricular parameters related to left ventricular function from gated-SPECT improved or not, using multivariate analysis.


METHODS
Ninety-six patients with cardiovascular diseases were studied. Gated-SPECT with the QGS software and left ventriculography (LVG) were performed to obtain left ventricular ejection fraction (LVEF), end-diastolic volume (EDV) and end-systolic volume (ESV). Then, multivariate analyses were performed to determine empirical formulas for predicting these parameters. The calculated values of left ventricular parameters were compared with those obtained directly from the QGS software and LVG.


RESULTS
Multivariate analyses were able to improve accuracy in estimation of LVEF, EDV and ESV. Statistically significant improvement was seen in LVEF (from r = 0.6965 to r = 0.8093, p < 0.05). Although not statistically significant, improvements in correlation coefficients were seen in EDV (from r = 0.7199 to r = 0.7595, p = 0.2750) and ESV (from r = 0.5694 to r = 0.5871, p = 0.4281).


CONCLUSION
The empirical equations with multivariate analysis improved the accuracy in estimating LVEF from gated-SPECT with the QGS software.
Towards the ictalurid catfish transcriptome: generation and analysis of 31,215 catfish ESTs

EST sequencing is one of the most efficient means for gene discovery and molecular marker development, and can be additionally utilized in both comparative genome analysis and evaluation of gene duplications. While much progress has been made in catfish genomics, large-scale EST resources have been lacking. The objectives of this project were to construct primary cDNA libraries, to conduct initial EST sequencing to generate catfish EST resources, and to obtain baseline information about highly expressed genes in various catfish organs to provide a guide for the production of normalized and subtracted cDNA libraries for large-scale transcriptome analysis in catfish. A total of 17 cDNA libraries were constructed including 12 from channel catfish (Ictalurus punctatus) and 5 from blue catfish (I. furcatus). A total of 31,215 ESTs, with average length of 778 bp, were generated including 20,451 from the channel catfish and 10,764 from blue catfish. Cluster analysis indicated that 73% of channel catfish and 67% of blue catfish ESTs were unique within the project. Over 53% and 50% of the channel catfish and blue catfish ESTs, respectively, had significant similarities to known genes. All ESTs have been deposited in GenBank. Evaluation of the catfish EST resources demonstrated their potential for molecular marker development, comparative genome analysis, and evaluation of ancient and recent gene duplications. Subtraction of abundantly expressed genes in a variety of catfish tissues, identified here, will allow the production of low-redundancy libraries for in-depth sequencing. The sequencing of 31,215 ESTs from channel catfish and blue catfish has significantly increased the EST resources in catfish. The EST resources should provide the potential for microarray development, polymorphic marker identification, mapping, and comparative genome analysis.
Toward automating a human behavioral coding system for married couples' interactions using speech acoustic features

Observational methods are fundamental to the study of human behavior in the behavioral sciences. For example, in the context of research on intimate relationships, psychologists’ hypotheses are often empirically tested by video recording interactions of couples and manually coding relevant behaviors using standardized coding systems. This coding process can be time-consuming, and the resulting coded data may have a high degree of variability because of a number of factors (e.g., inter-evaluator differences). These challenges provide an opportunity to employ engineering methods to aid in automatically coding human behavioral data. In this work, we analyzed a large corpus of married couples’ problem-solving interactions. Each spouse was manually coded with multiple session-level behavioral observations (e.g., level of blame toward other spouse), and we used acoustic speech features to automatically classify extreme instances for six selected codes (e.g., “low” vs. “high” blame). Specifically, we extracted prosodic, spectral, and voice quality features to capture global acoustic properties for each spouse and trained gender-specific and gender-independent classifiers. The best overall automatic system correctly classified 74.1% of the instances, an improvement of 3.95% absolute (5.63% relative) over our previously reported best results. We compare performance for the various factors: across codes, gender, classifier type, and feature type. 2011 Elsevier B.V. All rights reserved.
The VASOGRADE: A Simple Grading Scale for Prediction of Delayed Cerebral Ischemia After Subarachnoid Hemorrhage.

BACKGROUND AND PURPOSE
Patients are classically at risk of delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage. We validated a grading scale-the VASOGRADE-for prediction of DCI.


METHODS
We used data of 3 phase II randomized clinical trials and a single hospital series to assess the relationship between the VASOGRADE and DCI. The VASOGRADE derived from previously published risk charts and consists of 3 categories: VASOGRADE-Green (modified Fisher scale 1 or 2 and World Federation of Neurosurgical Societies scale [WFNS] 1 or 2); VASOGRADE-Yellow (modified Fisher 3 or 4 and WFNS 1-3); and VASOGRADE-Red (WFNS 4 or 5, irrespective of modified Fisher grade). The relation between the VASOGRADE and DCI was assessed by logistic regression models. The predictive accuracy of the VASOGRADE was assessed by receiver operating characteristics curve and calibration plots.


RESULTS
In a cohort of 746 patients, the VASOGRADE significantly predicted DCI (P<0.001). The VASOGRADE-Yellow had a tendency for increased risk for DCI (odds ratio [OR], 1.31; 95% CI, 0.77-2.23) when compared with VASOGRADE-Green; those with VASOGRADE-Red had a 3-fold higher risk of DCI (OR, 3.19; 95% CI, 2.07-4.50). Studies were not a significant confounding factor between the VASOGRADE and DCI. The VASOGRADE had an adequate discrimination for prediction of DCI (area under the receiver operating characteristics curve=0.63) and good calibration.


CONCLUSIONS
The VASOGRADE results validated previously published risk charts in a large and diverse sample of subarachnoid hemorrhage patients, which allows DCI risk stratification on presentation after subarachnoid hemorrhage. It could help to select patients at high risk of DCI, as well as standardize treatment protocols and research studies.
Effects of aerobic training during hemodialysis on heart rate variability and left ventricular function in end-stage renal disease patients.

INTRODUCTION
Decreased heart rate variability (HRV) in patients with end stage renal disease (ESRD) undergoing hemodialysis is predictive of cardiac death, especially due to sudden death.


OBJECTIVE
To evaluate the effects of aerobic training during hemodialysis on HRV and left ventricular function in ESRD patients.


METHODS
Twenty two patients were randomized into two groups: exercise (n = 11; 49.6 ± 10.6 years; 4 men) and control (n = 11; 43.5 ± 12.8; 4 men). Patients assigned to the exercise group were submitted to aerobic training, performed during the first two hours of hemodialysis, three times weekly, for 12 weeks. HRV and left ventricular function were assessed by 24 hours Holter monitoring and echocardiography, respectively.


RESULTS
After 12 weeks of protocol, no significant differences were observed in time and frequency domains measures of HRV in both groups. The ejection fraction improved non-significantly in exercise group (67.5 ± 12.6% vs. 70.4 ± 12%) and decreased non-significantly in control group (73.6 ± 8.4% vs. 71.4 ± 7.6%).


CONCLUSION
A 12-week aerobic training program performed during hemodialysis did not modify HRV and did not significantly improve the left ventricular function.
Maternal care and birth outcomes among ethnic minority women in Finland

BACKGROUND
Care during pregnancy and labour is of great importance in every culture. Studies show that people of migrant origin have barriers to obtaining accessible and good quality care compared to people in the host society. The aim of this study is to compare the access to and use of maternity services, and their outcomes among ethnic minority women having a singleton birth in Finland.


METHODS
The study is based on data from the Finnish Medical Birth Register in 1999-2001 linked with the information of Statistics Finland on woman's country of birth, citizenship and mother tongue. Our study data included 6,532 women of foreign origin (3.9% of all singletons) giving singleton birth in Finland during 1999-2001 (compared to 158,469 Finnish origin singletons).


RESULTS
Most women have migrated during the last fifteen years, mainly from Russia, Baltic countries, Somalia and East Europe. Migrant origin women participated substantially in prenatal care. Interventions performed or needed during pregnancy and childbirth varied between ethnic groups. Women of African and Somali origin had most health problems resulted in the highest perinatal mortality rates. Women from East Europe, the Middle East, North Africa and Somalia had a significant risk of low birth weight and small for gestational age newborns. Most premature newborns were found among women from the Middle East, North Africa and South Asia. Primiparous women from Africa, Somalia and Latin America and Caribbean had most caesarean sections while newborns of Latin American origin had more interventions after birth.


CONCLUSION
Despite good general coverage of maternal care among migrant origin women, there were clear variations in the type of treatment given to them or needed by them. African origin women had the most health problems during pregnancy and childbirth and the worst perinatal outcomes indicating the urgent need of targeted preventive and special care. These study results do not confirm either healthy migrant effect or epidemiological paradox according to which migrant origin women have considerable good birth outcomes.
Unveiling the Longitudinal Association between Short Sleep Duration and the Incidence of Obesity: the Penn State Cohort

Objective:Several epidemiologic, longitudinal studies have reported that short sleep duration is a risk factor for the incidence of obesity. However, the vast majority of these studies used self-reported measures of sleep duration and did not examine the role of objective short sleep duration, subjective sleep disturbances and emotional stress.Design:Longitudinal, population-based study.Subjects:We studied a random sample of 815 non-obese adults from the Penn State Cohort in the sleep laboratory for one night using polysomnography (PSG) and followed them up for a mean of 7.5 years. Subjective and objective measures of sleep as well as emotional stress were obtained at baseline. Obesity was defined as a body mass index (BMI) ⩾30 kg/ m-2.Results:The incidence of obesity was 15% and it was significantly higher in women and in individuals who reported sleep disturbances, shorter sleep duration and higher emotional stress. Significant mediating effects showed that individuals with subjective sleep disturbances who developed obesity reported the shortest sleep duration and the highest emotional stress, and that subjective sleep disturbances and emotional stress were independent predictors of incident obesity. Further analyses revealed that the association between short sleep duration, subjective sleep disturbances and emotional stress with incident obesity was stronger in young and middle-age adults. Objective short sleep duration was not associated with a significantly increased risk of incident obesity.Conclusion:Self-reported short sleep duration in non-obese individuals at risk of developing obesity is a surrogate marker of emotional stress and subjective sleep disturbances. Objective short sleep duration is not associated with a significant increased risk of incident obesity. The detection and treatment of sleep disturbances and emotional stress should become a target of our preventive strategies against obesity.
Rickets vs. abuse: a national and international epidemic

In the May 2007 issue of Pediatric Radiology, the article “Can classic metaphyseal lesions follow uncomplicated caesarean section?” [1] suggested that enough trauma could occur under these circumstances to produce fractures previously described as “highly specific for child abuse” [2]. However, the question of whether themetaphyses were normal to begin with was not raised. Why should this be an issue? Vitamin D deficiency (DD), initially believed to primarily affect the elderly and dark-skinned populations in the US, is now being demonstrated in otherwise healthy young adults, children, and infants of all races. In a review article on vitamin D published in the New England Journal of Medicine last year [3], Holick reviewed some of the recent literature, showing deficiency and insufficiency rates of 52% among Hispanic and African-American adolescents in Boston, 48% among white preadolescent females in Maine, 42% among African American females between 15 and 49 years of age, and 32% among healthy white men and women 18 to 29 years of age in Boston. A recent study of healthy infants and toddlers aged 8 to 24 months in Boston found an insufficiency rate of 40% and a deficiency rate of 12.1% [4]. In September 2007, a number of articles about congenital rickets were published in the Archives of Diseases in Childhood including an international perspective of mother and newborn DD reported from around the world [5]. Concentrations of 25-hydroxyvitamin D [25(OH)D] less than 25 nmol/l (10 ng/ml) were found in 18%, 25%, 80%, 42% and 61% of pregnant women in the UK, UAE, Iran, northern India and New Zealand, respectively, and in 60 to 84% of non-western women in the Netherlands. Currently, most experts in the US define DD as a 25(OH)D level less than 50 nmol/l (20 ng/ml). Levels between 20 and 30 ng/ml are considered to indicate insufficiency, reflecting increasing parathyroid hormone (PTH) levels and decreasing calcium absorption [3]. With such high prevalence of DD in our healthy young women, congenital deficiency is inevitable, since neonatal 25(OH)D concentrations are approximately two-thirds the maternal level [6]. Bodnar et al. [7] at the University of Pittsburgh, in the largest US study of mother and newborn infant vitamin D levels, found deficient or insufficient levels in 83% of black women and 92% of their newborns, as well as in 47% of white women and 66% of their newborns. The deficiencies were worse in the winter than in the summer. Over 90% of these women were on prenatal vitamins. Research is currently underway to formulate more appropriate recommendations for vitamin D supplementation during pregnancy (http://clinicaltrials.gov, ID: R01 HD043921). The obvious question is, “Why has DD once again become so common?” Multiple events have led to the high rates of DD. In the past, many foods were fortified with Pediatr Radiol (2008) 38:1210–1216 DOI 10.1007/s00247-008-1001-z
Early Access to the Cardiac Catheterization Laboratory for Patients Resuscitated From Cardiac Arrest Due to a Shockable Rhythm: The Minnesota Resuscitation Consortium Twin Cities Unified Protocol

BACKGROUND
In 2013 the Minnesota Resuscitation Consortium developed an organized approach for the management of patients resuscitated from shockable rhythms to gain early access to the cardiac catheterization laboratory (CCL) in the metro area of Minneapolis-St. Paul.


METHODS AND RESULTS
Eleven hospitals with 24/7 percutaneous coronary intervention capabilities agreed to provide early (within 6 hours of arrival at the Emergency Department) access to the CCL with the intention to perform coronary revascularization for outpatients who were successfully resuscitated from ventricular fibrillation/ventricular tachycardia arrest. Other inclusion criteria were age >18 and <76 and presumed cardiac etiology. Patients with other rhythms, known do not resuscitate/do not intubate, noncardiac etiology, significant bleeding, and terminal disease were excluded. The primary outcome was survival to hospital discharge with favorable neurological outcome. Patients (315 out of 331) who were resuscitated from VT/VF and transferred alive to the Emergency Department had complete medical records. Of those, 231 (73.3%) were taken to the CCL per the Minnesota Resuscitation Consortium protocol while 84 (26.6%) were not taken to the CCL (protocol deviations). Overall, 197 (63%) patients survived to hospital discharge with good neurological outcome (cerebral performance category of 1 or 2). Of the patients who followed the Minnesota Resuscitation Consortium protocol, 121 (52%) underwent percutaneous coronary intervention, and 15 (7%) underwent coronary artery bypass graft. In this group, 151 (65%) survived with good neurological outcome, whereas in the group that did not follow the Minnesota Resuscitation Consortium protocol, 46 (55%) survived with good neurological outcome (adjusted odds ratio: 1.99; [1.07-3.72], P=0.03).


CONCLUSIONS
Early access to the CCL after cardiac arrest due to a shockable rhythm in a selected group of patients is feasible in a large metropolitan area in the United States and is associated with a 65% survival rate to hospital discharge with a good neurological outcome.
Assessing structural changes in axial spondyloarthritis using a low-dose biplanar imaging system.

OBJECTIVES
Patients with axial SpA experience repeated spine imaging. EOS is a new low-dose imaging system with significantly lower irradiation than conventional radiography (CR). The objective was to explore the EOS performances compared with CR for the classification and follow-up of SpA.


METHODS
We performed an observational, cross-sectional, single-centre study including SpA patients (definite diagnosis by expert opinion) and control patients [definite chronic mechanical low back pain (cLBP)]. All patients underwent pelvic and frontal and lateral CR of the entire spine and two-dimensional (2D) EOS imaging on the same day. Images were blindly assessed for sacroiliitis [modified New York criteria (mNY)] and for ankylosis of the spine [modified Stoke AS Spine Score (mSASSS)]. Global ease of interpretation was rated on a scale of 0-10. The primary outcome was intermodality agreement, with an a priori defined non-inferiority limit of 0.7. Interobserver, intra-observer and intermodality agreement were measured by kappa, weighted kappa, intraclass correlation coefficient and Bland-Altman plots.


RESULTS
Forty-eight SpA patients [mean age 47.6 years (s.d. 14.9), symptom duration 21.4 years (s.d. 13.3), 35 (70%) men] and 48 cLBP controls [mean age 49.1 years (s.d. 10.7), 9 (22.5%) men] were included. Intermodality agreement between EOS and CR was 0.50 (95% CI 0.26, 0.75) and 0.97 (95% CI 0.95, 0.98) for sacroiliitis and mSASSS, respectively. Ease of interpretation was greater for CR [8.2 (s.d. 0.9)] compared with EOS [7.2 (s.d. 0.8), P < 0.0001).


CONCLUSION
Our results suggest that EOS could replace CR for the follow-up of structural damage of the spine, but its place in the classification of sacroiliitis needs to be further explored.
Collaborative navigation with ground vehicles and personal navigators

An integrated positioning solution termed `collaborative positioning' employs multiple location sensors with different accuracy on different platforms for sharing of their absolute and relative localizations. Typical application scenarios are dismounted soldiers, swarms of UAV's, team of robots, emergency crews and first responders. The stakeholders of the solution (i.e., mobile sensors, users, fixed stations and external databases) are involved in an iterative algorithm to estimate or improve the accuracy of each node's position based on statistical models. This paper studies the challenges to realize a public and low-cost solution, based on mass users of multiple-sensor platforms. For the investigation field experiments revolved around the concept of collaborative navigation, and partially indoor navigation. For this purpose different sensor platforms have been fitted with similar type of sensors, such as geodetic and low-cost high-sensitivity GNSS receivers, tactical grade IMU's, MEMS-based IMU's, miscellaneous sensors, including magnetometers, barometric pressure and step sensors, as well as image sensors, such as digital cameras and Flash LiDAR, and ultra-wide band (UWB) receivers. The employed platforms in the tests include a train on a building roof, mobile mapping vans, a personal navigator and a foot tracker unit. In terms of the tests, the data from the different platforms are recorded simultaneously. Several field experiments conducted in a week at the University of Nottingham are described and investigated in the paper. The personal navigator and a foot tracker unit moved on the building roof, then trough the building down to where it logged data simultaneously with the vans, all of them moving together and relative to each other. The platforms then logged data simultaneously covering various accelerations, dynamics, etc. over longer trajectories. Promising preliminary results of the field experiments showed that a positioning accuracy on the few meter level can be achieved for the navigation of the different platforms.
Australia - PaintMyTrip Travel

Among the seven continents of the world, Australia is the smallest by landmass and second smallest by population. When compared to other continents, australia is small But it is the sixth largest country in the world by landmass. Because of the concentrated..