LLukas22/scidocs huggingface dataset:
Reduced mortality in association with the acute respiratory distress syndrome (ARDS).

BACKGROUND
A study was undertaken to investigate possible reductions in mortality and/or changes in outcome predictive factors in patients with the acute respiratory distress syndrome (ARDS) managed in a single centre.


METHODS
The study was a prospective observational cohort study of two patient populations with ARDS. Group 1 comprised 41 patients enrolled between May 1990 and April 1993, and group 2 consisted of 78 patients enrolled between June 1993 and March 1997. The end points of the study were mortality and various factors predictive of death.


RESULTS
There was a marked reduction in mortality between groups 1 and 2 (66% versus 34%; relative risk 1.77; CI 1.23 to 2.55). There were no significant differences between the groups in terms of age (40.6 (3.3) versus 45.5 (2.2) years), APACHE score (14.5 (0.72) versus 13.6 (0.1)), lung injury score (2.95 (0.07) versus 2.8 (0.1)), incidence of multi-organ failure (29% versus 32%), incidence of sepsis (31% versus 39%), or PaO2/FIO2 (kPa) ratio (11.8 (0.67) versus 12.0 (0.6)). There was a significantly lower proportion of men in group 1 (51% versus 74%). The case mix of the two groups was closely matched: following elective surgery 48% versus 48%, trauma 17% versus 16%, primary lung injury 12% versus 24%. Patients in group 1 were supported using several ventilatory and other modes (volume preset, non-inverse ratio ventilation, n = 15; pressure controlled inverse ratio ventilation (PC-IRV), n = 11; ultra high frequency jet ventilation (UHFJV), n = 13; an intravascular oxygenation device (IVOX) and extracorporeal gas exchange (ECGE), n = 2). Within group 1 no significant difference in mortality was observed between the patients on volume controlled ventilation and the remainder. In group 2 all patients received PC-IRV (n = 78) but, in addition, some received other support techniques (UHFJV n = 4, ECGE n = 2). In group 1 only sepsis on admission (21% (survivors) versus 56% (non-survivors)) predicted death. In group 2 age of survivors and non-survivors (41.2 (2.6) versus 52.6 (3.5)), APACHE score (12.2 (0.6) versus 15.8 (0.9)), and PaO2/FIO2 (12.8 (0.86) versus 10.5 (0.72)) predicted survival, but not the incidence of sepsis or multi-organ failure.


CONCLUSIONS
In recent years a highly significant reduction in mortality associated with ARDS has been observed between two groups of patients well matched for disease severity and case mix. Changes in ICU organisation rather than specific interventions may account for this reduction, although different ventilatory and other management strategies used in the two groups may also be relevant.
Treatment of insomnia with hypnotics resulting in improved sexual functioning in post-menopausal women.

BACKGROUND
This study sought to determine whether trazodone used in hypnotic doses, compared to the hypnotic agent zopiclone, had any specific positive effect on sexual function in non-depressive post-menopausal women with insomnia.


SUBJECTS AND METHODS
Fifty (50) subjects participated in the study. Insomnia and sexual performance were evaluated before and after 4 weeks of hypnotic treatment.


RESULTS
At week four, both treatments improved sleep quality to a similar degree. Sexual function also improved significantly with both treatments, with no significant difference between the groups.


CONCLUSIONS
In post-menopausal women, sexual problems and sleep problems may be related and solving sleep problems may help sexual functioning, independently of depression.
Multitouch finger registration and its applications

We present a simple finger registration technique that can distinguish in real-time which hand and fingers of the user are touching the touchscreen. The finger registration process is activated whenever the user places a hand, in any orientation, anywhere on the touchscreen. Such a finger registration technique enables the design of intuitive multitouch interfaces that directly map different combinations of the user's fingers to the interface operations. In this paper, we first study the effectiveness and robustness of the finger registration process. We then demonstrate the usability of our finger registration method for two new interfaces. Specifically, we describe the Palm Menu, which is an intuitive dynamic menu interface that minimizes hand and eye movement during operations, and a virtual mouse interface that enables user to perform mouse operations in multitouch environment. We conducted controlled experiments to compare the performance of the Palm Menu against common command selection interfaces and the virtual mouse against traditional pointing devices.
TRIZ for software architecture

A key element to designing software architectures of good quality is the systematic handling of contradicting quality requirements and the structuring principles that support them. The theory of inventive problem solving (TRIZ) by Altshuller offers tools that can be used to define such a systematic way. This paper describes the idea and preliminary results of using inventive principles and the contradiction matrix for the resolution of contradictions in the design of software architectures. By rearchitecting a flight simulation system these tools are analysed and their further development is proposed. © 2010 Published by Elsevier Ltd.
Dynamic Allocation of Pharmaceutical Detailing and Sampling for Long-Term Profitability

T U.S. pharmaceutical industry spent upwards of $18 billion on marketing drugs in 2005; detailing and drug sampling activities accounted for the bulk of this spending. To stay competitive, pharmaceutical managers need to maximize the return on these marketing investments by determining which physicians to target as well as when and how to target them. In this paper, we present a two-stage approach for dynamically allocating detailing and sampling activities across physicians to maximize long-run profitability. In the first stage, we estimate a hierarchical Bayesian, nonhomogeneous hidden Markov model to assess the shortand long-term effects of pharmaceutical marketing activities. The model captures physicians’ heterogeneity and dynamics in prescription behavior. In the second stage, we formulate a partially observable Markov decision process that integrates over the posterior distribution of the hidden Markov model parameters to derive a dynamic marketing resource allocation policy across physicians. We apply the proposed approach in the context of a new drug introduction by a major pharmaceutical firm. We identify three prescription-behavior states, a high degree of physicians’ dynamics, and substantial longterm effects for detailing and sampling. We find that detailing is most effective as an acquisition tool, whereas sampling is most effective as a retention tool. The optimization results suggest that the firm could increase its profits substantially while decreasing its marketing spending. Our suggested framework provides important implications for dynamically managing customers and maximizing long-run profitability.
The association between duration of breastfeeding and adult intelligence.

CONTEXT
A number of studies suggest a positive association between breastfeeding and cognitive development in early and middle childhood. However, the only previous study that investigated the relationship between breastfeeding and intelligence in adults had several methodological shortcomings.


OBJECTIVE
To determine the association between duration of infant breastfeeding and intelligence in young adulthood.


DESIGN, SETTING, AND PARTICIPANTS
Prospective longitudinal birth cohort study conducted in a sample of 973 men and women and a sample of 2280 men, all of whom were born in Copenhagen, Denmark, between October 1959 and December 1961. The samples were divided into 5 categories based on duration of breastfeeding, as assessed by physician interview with mothers at a 1-year examination.


MAIN OUTCOME MEASURES
Intelligence, assessed using the Wechsler Adult Intelligence Scale (WAIS) at a mean age of 27.2 years in the mixed-sex sample and the Børge Priens Prøve (BPP) test at a mean age of 18.7 years in the all-male sample. Thirteen potential confounders were included as covariates: parental social status and education; single mother status; mother's height, age, and weight gain during pregnancy and cigarette consumption during the third trimester; number of pregnancies; estimated gestational age; birth weight; birth length; and indexes of pregnancy and delivery complications.


RESULTS
Duration of breastfeeding was associated with significantly higher scores on the Verbal, Performance, and Full Scale WAIS IQs. With regression adjustment for potential confounding factors, the mean Full Scale WAIS IQs were 99.4, 101.7, 102.3, 106.0, and 104.0 for breastfeeding durations of less than 1 month, 2 to 3 months, 4 to 6 months, 7 to 9 months, and more than 9 months, respectively (P =.003 for overall F test). The corresponding mean scores on the BPP were 38.0, 39.2, 39.9, 40.1, and 40.1 (P =.01 for overall F test).


CONCLUSION
Independent of a wide range of possible confounding factors, a significant positive association between duration of breastfeeding and intelligence was observed in 2 independent samples of young adults, assessed with 2 different intelligence tests.
Reduction of relative centrifugal forces increases growth factor release within solid platelet-rich-fibrin (PRF)-based matrices: a proof of concept of LSCC (low speed centrifugation concept)

Purpose The present study evaluated the platelet distribution pattern and growth factor release (VEGF, TGF-β1 and EGF) within three PRF (platelet-rich-fibrin) matrices (PRF, A-PRF and A-PRF+) that were prepared using different relative centrifugation forces (RCF) and centrifugation times. Materials and methods immunohistochemistry was conducted to assess the platelet distribution pattern within three PRF matrices. The growth factor release was measured over 10 days using ELISA. Results The VEGF protein content showed the highest release on day 7; A-PRF+ showed a significantly higher rate than A-PRF and PRF. The accumulated release on day 10 was significantly higher in A-PRF+ compared with A-PRF and PRF. TGF-β1 release in A-PRF and A-PRF+ showed significantly higher values on days 7 and 10 compared with PRF. EGF release revealed a maximum at 24 h in all groups. Toward the end of the study, A-PRF+ demonstrated significantly higher EGF release than PRF. The accumulated growth factor releases of TGF-β1 and EGF on day 10 were significantly higher in A-PRF+ and A-PRF than in PRF. Moreover, platelets were located homogenously throughout the matrix in the A-PRF and A-PRF+ groups, whereas platelets in PRF were primarily observed within the lower portion. ​Discussion the present results show an increase growthfactor release by decreased RCF. However, further studies must be conducted to examine the extent to which enhancing the amount and the rate of released growth factors influence wound healing and biomaterial-based tissue regeneration. ​Conclusion These outcomes accentuate the fact that with a reduction of RCF according to the previously LSCC (described low speed centrifugation concept), growth factor release can be increased in leukocytes and platelets within the solid PRF matrices.
High-efficiency design of multiphase synchronous mode soft-switching converter for wide input and load range

A four-phase interleaved bidirectional dc-dc converter with coupled inductor is adopted in both boost- and buck-mode operations. The circuit allows synchronous mode operation to achieve zero-voltage switching. Together with the use of low Rds-on power MOSFET as the switching device, ultra high efficiency can be obtained. This paper shows a high-voltage example system operating completely in synchronous mode with 99.2% efficiency at the full load, but only 93% at 10% load. A low-voltage system example is then proposed to operate in synchronous mode under light-load condition and in continuous conducting mode under heavy load condition to achieve high efficiency over a wide load range. The peak efficiency of the second example system reaches 99.5% in between 10 and 20% load and maintains above 98% throughout the rest of load range.
Closing a Front Door to Homelessness among Veterans

The U.S. Department of Veterans Affairs (VA) has been identified as a mainstream institution to help prevent homelessness among America’s veterans. The large numbers of incarcerated veterans with serious mental illnesses and substance abuse disorders who are at risk for homelessness support the need for expanded VA outreach to this population. Since 2002, the VA has contacted almost 6,500 veterans in prison or jail. Its leadership role in affording comprehensive health, mental health, social resources, corrections outreach, and current policy and planning strategies positions the VA to provide system wide service to veterans leaving correctional institutions. As this VA outreach program proceeds, examining the links among program assumptions, veteran needs and outcomes, and existing evaluation processes can help to maintain focus on homelessness prevention strategies.
Knowledge, attitude and practice assessment of construction workers for HIV/AIDS in Sri Lanka.

BACKGROUND
Human immunodeficiency virus (HIV) prevalence is relatively lower in Sri Lanka than in other Asian countries; however, the number of HIV-infected persons has rapidly increased in recent years.


METHODOLOGY
A baseline study on HIV, acquired immunodeficiency virus (AIDS), and sexually transmitted infections (STI) knowledge, attitude, and practice was conducted at two construction sites in Sri Lanka from January to February 2007 to design an effective intervention strategy for the construction workers.


RESULTS
Among 611 respondents (mostly males, mean age 32.8 years), nearly two-thirds lived away from home. Knowledge was fairly good on AIDS prevention but poorer on STI than on HIV. Some misconceptions were also observed. A high percentage did not consider HIV/AIDS as their own personal issue, and over 50% respondents expressed discriminatory attitudes towards HIV positives. Condom access was limited due to social and cultural norms. Mobility was not significantly associated with practice of prevention of HIV and STI.


CONCLUSION
This study showed that the construction workers were not specially at higher risk of HIV at that time. In order to minimize the potential risk of infection, however, it would be effective to reduce stigma and discrimination among them through the prevention program, working together with community or religious leaders in the areas. More comprehensive assessment among other population groups would also be beneficial to identify their risk of infection.
Effects of a new sensory re-education training tool on hand sensibility and manual dexterity in people with multiple sclerosis.

OBJECTIVE
To describe and evaluate the effects of a new home-based sensory re-education training tool on hand sensibility and manual dexterity in people with MS experiencing upper limb sensory deficits.


METHODS
Twenty-five people with relapsing-remitting MS (18 women), mean age 50.6 years (SD = 11.4), volunteered to participate. Participants were initially assigned to a 7-week control phase followed by a 3-week home-based sensory re-education phase. Measurements used were the nine-hole peg test, the two point discrimination test, the monofilaments test and the functional dexterity test. Measurements were collected at baseline, following the control phase and at the end of the trial.


RESULTS
Participants demonstrated an improvement in the nine-hole peg (26.8 (SD = 3.5) vs. 22.6 (SD = 3.2); mean difference (95% CI) 4.9 (0.9, 7.1), P = 0.03) and functional dexterity tests (38.6 (SD = 4.4) vs. 33.8 (SD = 4.9); mean difference (95% CI) 4.8 (1.8, 7.0); P = 0.02) at the end of the sensory re-education phase compared to the end of the control phase. No differences were observed as to the monofilaments and two-point discrimination tests.


CONCLUSIONS
Sensory re-education training does not affect the level of sensory impairment in the hand but may lead to improvement in select measures of manual dexterity.
Psilocybin – Summary of knowledge and new perspectives

Psilocybin, a psychoactive alkaloid contained in hallucinogenic mushrooms, is nowadays given a lot of attention in the scientific community as a research tool for modeling psychosis as well as due to its potential therapeutic effects. However, it is also a very popular and frequently abused natural hallucinogen. This review summarizes all the past and recent knowledge on psilocybin. It briefly deals with its history, discusses the pharmacokinetics and pharmacodynamics, and compares its action in humans and animals. It attempts to describe the mechanism of psychedelic effects and objectify its action using modern imaging and psychometric methods. Finally, it describes its therapeutic and abuse potential.
Interruption of treatment with individual therapeutic drug classes in adults with multidrug-resistant HIV-1 infection.

BACKGROUND
Many antiretroviral-treated human immunodeficiency virus (HIV)-infected patients experience sustained immunologic and virologic benefit despite the presence of multidrug-resistant HIV. We hypothesized that the use of simplified regimens could maintain treatment benefit while preventing viral evolution and reducing drug-related toxicity and costs.


METHODS
We conducted a 48-week nonrandomized study of adults with multidrug-resistant HIV type 1 infection. Subjects interrupted protease inhibitor (PI) (n=18), reverse-transcriptase inhibitor (RTI) (n=6), or nonnucleoside RTI (NNRTI) (n=6) treatment.


RESULTS
At study entry, subjects had a median reduction in HIV RNA levels of 1.2 log10 copies/mL relative to pretreatment levels. Interruption of PI treatment was associated with stable HIV RNA levels (mean change per week, +0.005 log10 copies/mL; P=.36). PI mutations waned and replicative capacity and HIV RNA levels increased after long-term observation. HIV RNA levels also remained stable in subjects interrupting NNRTI treatment. In contrast, all subjects who interrupted RTI treatment exhibited immediate increases in HIV RNA levels, and most exhibited a subsequent loss of the M184V mutation.


CONCLUSIONS
These data indicate that nucleoside analogues often exert continued antiviral activity in the setting of drug-resistance mutations and that both nucleoside analogues and PIs can select for drug-resistance mutations that reduce viral fitness. These observations support the evaluation of treatment strategies aimed at maintaining the treatment benefit of therapy while reducing drug exposure.
Early versus late maturation arrest: reproductive outcomes of testicular failure.

PURPOSE
There is a paucity of data characterizing infertile men with maturation arrest. We hypothesized that men with early stage maturation arrest could be clinically distinguished from men with late maturation arrest and would have worse reproductive outcomes.


MATERIALS AND METHODS
We retrospectively reviewed the records of all patients with nonobstructive azoospermia and cryptozoospermia who underwent testis mapping and sperm extraction from 2002 to 2009 and for whom histopathological findings were available. Patients had uniform maturation arrest if multiple biopsies revealed maturation arrest at the spermatogonia/spermatocyte (early maturation arrest) or the spermatid (late maturation arrest) stage. Clinical parameters and pregnancy outcomes of in vitro fertilization/intracytoplasmic sperm injection were examined. Statistical analysis consisted of univariate and multivariate analysis.


RESULTS
Uniform maturation arrest was identified in 49 of 219 men (22.3%) undergoing testicular sperm extraction. On multivariate analysis men with maturation arrest had significantly larger testes (p=0.01), decreased follicle-stimulating hormone (p=0.05) and more detectable genetic abnormalities (p=0.01) than men with other histopathological conditions. Men with late maturation arrest had decreased follicle-stimulating hormone (p=0.02), increased testosterone (p=0.03) and a higher sperm retrieval rate at testicular sperm extraction (p=0.01) than men with early maturation arrest. Predictors of successful sperm retrieval were larger testes, cryptozoospermia, late maturation arrest and hypospermatogenesis (each p≤0.05). Pregnancy outcomes for men with maturation arrest were not significantly different from those for men with other histopathological conditions.


CONCLUSIONS
Maturation arrest is a common, diverse histopathological subtype of severe male infertility. Compared to men with late maturation arrest those with early maturation arrest have increased follicle-stimulating hormone, decreased testosterone and a decreased probability of mature spermatozoa. In vitro fertilization/intracytoplasmic sperm injection outcomes were similar when spermatozoa were discovered during testicular sperm extraction.
Enhanced production of asiaticoside from hairy root cultures of Centella asiatica (L.) Urban elicited by methyl jasmonate

Transformed root (“hairy root”) cultures have been shown to be a good model for the study of many secondary metabolites. However, economically important compounds such as asiaticoside and madecassoside are produced in insignificant amounts in the root of Centella asiatica (L.) Urban. To overcome this problem, C. asiatica was transformed using Agrobacterium rhizogenes strain R1000 that harbors pCAMBIA1302 encoding the hygromycin phosphotransferase (hpt) and green fluorescence protein (mgfp5) genes and the hairy culture was coupled with elicitation technique. Hairy roots were obtained at a frequency of up to 14.1% from a tissue junction between the leaf and petiole. Abundant hairy roots were observed when co-cultivation of the plant with A. rhizogenes was done for 7 days (36.1%). Transformation was confirmed by PCR and Southern blot analyses. Five weeks after inoculation, no asiaticoside was detected in the hairy root samples. However, when 0.1 mM methyl jasmonate (MJ) was applied as an elicitor to the culture medium for 3 weeks, a large quantity of asiaticoside was generated (7.12 mg/g, dry wt). In the case of gene expression, 12 h after MJ treatment the expression of the CabAS (C. asiatica putative β-amyrin synthase) gene in the hairy roots is significantly different from that of the control and this level of transcripts was maintained for 14 days. Our results showed that production of C. asiatica hairy roots could be optimized and the resulting cultures could be elicited with MJ treatment for enhanced production of asiaticoside.
Modeling opinion dynamics in social networks

Our opinions and judgments are increasingly shaped by what we read on social media -- whether they be tweets and posts in social networks, blog posts, or review boards. These opinions could be about topics such as consumer products, politics, life style, or celebrities. Understanding how users in a network update opinions based on their neighbor's opinions, as well as what global opinion structure is implied when users iteratively update opinions, is important in the context of viral marketing and information dissemination, as well as targeting messages to users in the network.
 In this paper, we consider the problem of modeling how users update opinions based on their neighbors' opinions. We perform a set of online user studies based on the celebrated conformity experiments of Asch [1]. Our experiments are carefully crafted to derive quantitative insights into developing a model for opinion updates (as opposed to deriving psychological insights). We show that existing and widely studied theoretical models do not explain the entire gamut of experimental observations we make. This leads us to posit a new, nuanced model that we term the BVM. We present preliminary theoretical and simulation results on the convergence and structure of opinions in the entire network when users iteratively update their respective opinions according to the BVM. We show that consensus and polarization of opinions arise naturally in this model under easy to interpret initial conditions on the network.