LLukas22/scidocs huggingface dataset:
Influence of estrogen therapy on calcium, phosphorus, and other regulatory hormones in postmenopausal women: the MESA study.

BACKGROUND
Estrogen therapy (ET) is associated with lower serum calcium and phosphorus concentrations and is known to increase bone mineral density (BMD). Other biomarkers of mineral metabolism may help understand the biological basis of these actions.


METHODS
We studied 2767 postmenopausal women in the Multi-Ethnic Study of Atherosclerosis, 862 (31%) of whom were using ET. We measured serum concentrations of calcium, phosphorus, 25-hydroxyvitamin D, 24,25-dihydoxyvitamin D, and fibroblast growth factor-23 and urinary fractional excretion of calcium (FEca) and phosphorus (FEphos). We examined the associations of ET with each biomarker. In addition, we tested whether the adjustment for biomarkers attenuated the association of ET with lumbar BMD measured by abdominal computed tomography in a subset of 810 women.


RESULTS
In adjusted models, women who used ET were younger in age [62 (SD 8) vs 66 (9) y, P < .001], had lower mean serum calcium [-13 mg/dL (95% confidence interval [CI] -0.17, -0.10), P < .001] and lower FEca [-0.15% (95% CI -0.21, -0.09), P < .001]. Mean serum phosphorus was lower [-0.19 mg/dL (95% CI -0.23, -0.15), P < .001] and FEphos [0.56% (95% CI 0.16, 0.96), P = .007] was higher in women on ET. Mean 25-hydroxyvitamin D and 24,25-dihydroxyvitamin D were higher [1.52 ng/dL (95% CI 0.57, 2.47), P = .002, and 0.26 ng/mL (95% CI 0.03, 0.48), P = .03, respectively] in women who used ET. Mean PTH and fibroblast growth factor-23 did not differ significantly by the use of ET. ET use was strongly associated with higher lumbar BMD [12.75 mg/cm³ (95% CI 7.77-17.73), P < .001]; however, mineral metabolism measures did not meaningfully alter this association.


CONCLUSIONS
In a multiethnic cohort of postmenopausal women, ET use was associated with lower serum calcium, lower FEca, lower serum phosphorus, and higher FEphos, suggesting these associations are attributable to increased calcium intake into bone and increased urinary phosphorus excretion. ET use was also associated with greater concentrations of vitamin D metabolites. ET-associated differences in these mineral metabolism measures did not meaningfully attenuate the strong association between ET use and lumbar BMD.
Segmentation of overlapping cervical cells: A variational method with star-shape prior

Accurate and automatic detection and delineation of cervical cells are two critical precursor steps to automatic Pap smear image analysis and detecting pre-cancerous changes in the uterine cervix. To overcome noise and cell occlusion, many segmentation methods resort to incorporating shape priors, mostly enforcing elliptical shapes (e.g. [1]). However, elliptical shapes do not accurately model cervical cells. In this paper, we propose a new continuous variational segmentation framework with star-shape prior using directional derivatives to segment overlapping cervical cells in Pap smear images. We show that our star-shape constraint better models the underlying problem and outperforms state-of-the-art methods in terms of accuracy and speed.
Palmprint verification using binary orientation co-occurrence vector

The development of accurate and robust palmprint verification algorithms is a critical issue in automatic palmprint authentication systems. Among various palmprint verification approaches, the orientation based coding methods, such as competitive code (CompCode), palmprint orientation code (POC) and robust line orientation code (RLOC), are state-of-the-art ones. They extract and code the locally dominant orientation as features and could match the input palmprint in real-time and with high accuracy. However, using only one dominant orientation to represent a local region may lose some valuable information because there are cross lines in the palmprint. In this paper, we propose a novel feature extraction algorithm, namely binary orientation co-occurrence vector (BOCV), to represent multiple orientations for a local region. The BOCV can better describe the local orientation features and it is more robust to image rotation. Our experimental results on the public palmprint database show that the proposed BOCV outperforms the CompCode, POC and RLOC by reducing the equal error rate (EER) significantly. 2009 Elsevier B.V. All rights reserved.
A systematic review and meta-analysis of Baihui (GV20)-based scalp acupuncture in experimental ischemic stroke

Acupuncture for stroke has been used in China for over 2,000 years and nowadays is increasingly practiced elsewhere in the world. However, previous studies had conflicting findings on the results of acupuncture. Here, we conducted a systematic review and meta-analysis to assess the current evidence for the effect of Baihui (GV20)-based scalp acupuncture in animal models of focal cerebral ischemia. Six databases from the inception of each database up to June 2013 were electronically searched. Primary outcomes were infarct size and neurobehavioral outcome. Ultimately, 54 studies involving 1816 animals were identified describing procedures. Meta-analysis results showed that twelve studies reported significant effects of Baihui (GV20)-based scalp acupuncture for improving infarct volume compared with middle cerebral artery occlusion group (P < 0.01), and thirty-two studies reported significant effects of Baihui (GV20)-based scalp acupuncture for improving the neurological function score when compared with the control group (P < 0.01). In conclusion, Baihui (GV20)-based scalp acupuncture could improve infarct volume and neurological function score and exert potential neuroprotective role in experimental ischemic stroke.
Distributed clustering algorithms for data-gathering in wireless mobile sensor networks

One critical issue in wireless sensor networks is how to gather sensed information in an energy-efficient way since the energy is a scarce resource in a sensor node. Cluster-based architecture is an effective architecture for data-gathering in wireless sensor networks. However, in a mobile environment, the dynamic topology poses the challenge to design an energy-efficient data-gathering protocol. In this paper, we consider the cluster-based architecture and provide distributed clustering algorithms for mobile sensor nodes which minimize the energy dissipation for data-gathering in a wireless mobile sensor network. There are two steps in the clustering algorithm: cluster-head election step and cluster formation step. We first propose two distributed algorithms for cluster-head election. Then, by considering the impact of node mobility, we provide a mechanism to have a sensor node select a proper cluster-head to join for cluster formation. Our clustering algorithms will achieve the following three objectives: (1) there is at least one cluster-head elected, (2) the number of cluster-heads generated is uniform, and (3) all the generated clusters have the same cluster size. Last, we validate our algorithms through an extensive experimental analysis with Random Walk Mobility (RWM) model, Random Direction Mobility (RDM) model, and a Simple Mobility (SM) model as well as present our findings. © 2007 Elsevier Inc. All rights reserved.
Crossing Minimization Problems of Drawing Bipartite Graphs in Two Clusters

The crossing minimization problem is a classic and very important problem in graph drawing (Pach, Tòth 1997); the results directly affect the effectiveness of the layout, especially for very large scale graphs. But in many cases crossings cannot be avoided. In this paper we present two models for bipartite graph drawing, aiming to reduce crossings that cannot be avoided in the traditional bilayer drawings. We characterize crossing minimization problems in these models, and prove that they are NP-complete.
Mesures de défaut de compacité, application au système de Lamé

– We define the microlocal defect measures for boundary value systems satisfying the strong Lopatinski condition and we apply these notions to the study of the asymptotic propagation of the energy for the solutions of the Lamé system.  2001 Éditions scientifiques et médicales Elsevier SAS
The diagnostic challenge of small fibre neuropathy: clinical presentations, evaluations, and causes

Small fibre neuropathies are a heterogeneous group of disorders affecting thinly myelinated Aδ-fibres and unmyelinated C-fibres. Although multiple causes of small nerve fibre degeneration have been reported, including via genetic mutations, the cause of small fibre neuropathy remains unknown in up to 50% of cases. The typical clinical presentation of small fibre neuropathy is that of a symmetrical, length-dependent polyneuropathy associated with sensory or autonomic symptoms. More rarely, the clinical presentation is characterised by non-length-dependent, focal, or multifocal symptoms. The diagnostic tests to identify small fibre neuropathy include skin biopsy, quantitative sensory, and autonomic testing. Additional tests, such as those measuring small fibre-related evoked potentials and corneal confocal microscopy, might contribute to a better understanding of these neuropathies. Biochemical markers can also help in screening patients for the presence of small fibre neuropathy and to assess disease progression.
Impact of in-stent minimal lumen area at 9 months poststent implantation on 3-year target lesion revascularization-free survival: a serial intravascular ultrasound analysis from the TAXUS IV, V, and VI trials.

BACKGROUND
Intravascular ultrasound (IVUS) is used to assess intermediate lesions in native coronary arteries; minimum lumen area (MLA) <4.0 mm(2) is accepted as a cutoff for a significant stenosis. We evaluated the IVUS in-stent MLA at 9-month follow-up that best predicted subsequent target lesion revascularization (TLR)-free survival in patients from the TAXUS IV, V, and VI studies.


METHODS AND RESULTS
In the combined TAXUS IV, V, and VI randomized trials, 9-month IVUS was available in 635 patients (331 treated with paclitaxel-eluting stents [PES] and 304 treated with bare-metal stents [BMS]) who did not require TLR in the first 9 months postintervention and who were followed for 3 years. The in-stent MLA that best predicted 3-year TLR-free survival was determined. At 9-months follow-up, IVUS-measured in-stent MLA was 5.7 + or -2.3 mm(2) in the PES group and 4.8 + or - 2.3 mm(2) in the BMS group. Between 9 months and 3 years, TLR was required in 4.9% of patients who were treated with PES and 6.7% of patients who were treated with BMS. Multivariate analysis identified MLA at 9 months as a significant predictor of late TLR (hazard ratio, 0.63 [0.43-0.93]; P = 0.02). The ability of MLA to predict late TLR was further assessed using receiver operating characteristic analysis. MLA was found to be an acceptable discriminator for both PES (c = 0.7448) and BMS (c = 0.7329). Finally, the optimal thresholds of MLA that best predicted subsequent TLR-free survival were determined to be 4.2 mm(2) for PES and 4.0 mm(2) for BMS.


CONCLUSIONS
In the combined IVUS analysis of TAXUS IV, V, and VI, patients who did not require TLR within the first 9 months had a high subsequent TLR-free survival rate whether treated with PES or BMS. MLA measured by IVUS at 9 months predicted subsequent TLR with a cutoff similar to intermediate, de novo lesions in native coronary arteries.
Aquatic numerical modelling — A management tool regarding dispersion and decay of pollutants

Abstract Numerical models are valuable tools in water quality management. The paper provides an introduction to the application of numerical models in aquatic environmental management. The introduction takes it offset in the needs of management tools and the basic mass balance of a suspended/dissolved substance. The questions of when and how to benefit from numerical models are discussed. Four cases are used to illustrate the span in present application of numerical models in aquatic environmental management. The paper also addresses the future challenges for development of models.
Racial/ethnic differences in pregnancy-related hypertensive disease in nulliparous women.

OBJECTIVE
Hypertension and cardiovascular disease rates vary by race/ethnicity in nonpregnant adults. We aimed to examine racial/ethnic differences in prevalence and severity of hypertensive diseases during pregnancy in nulliparous women.


DESIGN, SETTING, PARTICIPANTS
Nulliparous women with singleton deliveries and electronic medical record data on demographics and pregnancy outcomes (n = 56,617) were selected from the Consortium on Safe Labor (2002-2008). Multivariable logistic regression was performed to calculate the adjusted odds of gestational hypertension, mild preeclampsia, severe preeclampsia, eclampsia, chronic hypertension, superimposed preeclampsia, and unspecified hypertension for women who were non-Hispanic Black, Hispanic, Asian/Pacific Islander, and multiracial/other race/ethnicity, compared with non-Hispanic White women.


RESULTS
Non-Hispanic Black women had higher odds of entering pregnancy with chronic hypertension (adjusted odds ratio (AOR) = 1.43, 95% confidence interval (CI) 1.11-1.84) and had higher odds of developing mild (AOR = 1.26, 95% Cl 1.10-1.45), severe (AOR = 1.31, 95% Cl 1.10-1.57) or superimposed preeclampsia (AOR = 1.98, 95% ClI 1.40-2.80) compared to non-Hispanic White women. Hispanic women and Asian/Pacific Islanders had higher odds of remaining normotensive (AOR = 1.22, 95% CI 1.12-1.33 and AOR=1.55, 95% CI 1.31-1.84, respectively). Conclusions: Odds for specific gestational hypertensive diseases varied by race/ethnicity among women during their first pregnancy. Non-Hispanic Black women experienced more severe disease, while Hispanic women and Asian/Pacific Islanders had an overall decreased risk compared to non-Hispanic Whites. Patterns of racial/ethnic variation associated with hypertensive diseases during pregnancy were similar to racial/ethnic associations reported for adult-onset cardiovascular disease, suggesting that there may be common pathways and shared risk factors.
Effect of Electrode Configuration and Capacitor Size on Internal Atrial Defibrillation Threshold Using Leads Currently Used for Ventricular Defibrillation.

Background: Previous studies have shown that endocardial atrial defibrillation, using lead configurations specifically designed for ventricular defibrillation, is feasible but the substantial patient discomfort might prevent the widespread use of the technique unless significant improvements in shock tolerability are achieved. It has been suggested that the peak voltage or the peak current but not the total energy delivered determines the patient pain perception and therefore, lower defibrillating voltage and current achieved with modifications in lead and waveforms may increase shock tolerability. This study was undertaken to evaluate the effect, on the atrial defibrillation threshold (ADFT), of the addition of a patch electrode (mimicking the can electrode) to the right ventricle (RV)-superior vena cava (SVC) lead configuration. The influence of capacitor size on ADFT using the RV-SVC+skin patch configuration was also assessed. Methods: In 10 patients (pts) (Group 1) cardioversion thresholds were evaluated using biphasic shocks in two different configurations: 1) right ventricle (RV) to superior vena cava (SVC); 2) RV to SVC+skin patch. In a second group of twelve patients (Group 2) atrial defibrillation thresholds of biphasic waveforms that differed with the total capacitance (90 or 170 µF) were assessed using the RV to SVC+skin patch configuration. Results: In Group 1 AF was terminated in 10/10 pts (100 %) with both configurations. There was no significant difference in delivered energy at the defibrillation threshold between the two configurations (7.1 ± 5.1 J vs 7.1 ± 2.6 J; p < 0.05). In group 2 AF was terminated in 12/12 pts (100%) with both waveforms. The 170 µF waveform provided a significantly lower defibrillating voltage (323.7 ± 74.6 V vs 380 ± 70.2 V; p < 0.03) and current (8.1 ± 2.7 A vs 10.0 ± 2.3 A; p < 0.04) than the 90 µF waveform. All pts, in both groups, perceived the shock of the lowest energy tested (180 V) as painful or uncomfortable. Conclusions: The addition of a patch electrode to the RV-SVC lead configuration does not reduce the ADFT. Shocks from larger capacitors defibrillate with lower voltage and current but pts still perceive low energy subthreshold shocks as painful or uncomfortable.
A New Type of Socio-Economic System

By permission of MIT Press reproduced below is the full text of Orcutt G (1957) ‘A new type of socio-economic system’, Review of Economics and Statistics, 39(2), 116-123.
Measuring neuromuscular fatigue in cervical spinal musculature of military helicopter aircrew.

UNLABELLED
Neck pain and muscle function in aircrew have received considerable attention. We hypothesized normalized electromyography (EMG) frequency would provide insight into appropriate methods to assess muscle fatigue in helicopter aircrew.


METHODS
40 helicopter aircrew performed isometric testing that included maximal voluntary contractions (MVC) and 70% MVC endurance protocols of extension, flexion, and left and right lateral flexion for cervical muscles. Bilateral muscle activity in the splenius capitis, sternocleidomastoid, and upper trapezius was monitored with EMG. Normalized mean EMG frequency was calculated for each muscle at the start and end of the 70% MVC trials to determine which muscles fatigued and limited force maintenance during each isometric movement.


RESULTS
For extension, the left and right splenius capitis fatigued by approximately 21-22% (p < 0.01); for flexion, the left and right sternocleidomastoid fatigued by approximately 11-14% (p < 0.01); for right flexion, the right sternocleidomastoid fatigued by approximately 15% (p < 0.01); for left flexion, the left spenus capitis and left sternocleidomastoid fatigued by approximately 7.2% (p = 0.02) and approximately 11.2% (p = 0.03), respectively; in no trials did the trapezius muscles display fatigue as measured by EMG.


CONCLUSION
The smaller agonist muscles were the most susceptible to fatigue during submaximal isometric endurance movements in the cervical muscles of helicopter aircrew.
Psychophysical measures of visual acuity in autism spectrum conditions

Previously reported superior visual acuity (VA) in autism spectrum conditions (ASC) may have resulted from methodological settings used (Ashwin, Ashwin, Rhydderch, Howells, & Baron-Cohen, 2009). The current study re-tested whether participants with (N=20) and without (N=20) ASC differ on psychophysical measures of VA. Participants' vision was corrected before acuity measurement, minimising refractive blur. VA was assessed with an ETDRS chart as well as the Freiburg Visual Acuity and Contrast Test (FrACT). FrACT testing was undertaken at 4m (avoiding limitations of pixel-size), using 36 trials (avoiding fatigue). Best corrected VA was significantly better than the initial habitual acuity in both groups, but adults with and without ASC did not differ on ETDRS or FrACT binocular VA. Future research should examine at which level of visual processing sensory differences emerge.
Long-Term Results of the HD2000 Trial Comparing ABVD Versus BEACOPP Versus COPP-EBV-CAD in Untreated Patients With Advanced Hodgkin Lymphoma: A Study by Fondazione Italiana Linfomi.

PURPOSE
The randomized HD2000 trial compared six cycles of ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine), four escalated plus two standard cycles of BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone), and six cycles of COPP-EBV-CAD (cyclophosphamide, lomustine, vindesine, melphalan, prednisone, epidoxorubicin, vincristine, procarbazine, vinblastine, and bleomycin; CEC) in patients with advanced-stage Hodgkin lymphoma. After a median follow-up of 42 months, patients who received BEACOPP were reported to have experienced better progression-free survival (PFS) but not better overall survival (OS) results than those receiving ABVD. We here report a post hoc analysis of this trial after a median follow-up of 10 years.


PATIENTS AND METHODS
Three hundred seven patients were enrolled, 295 of whom were evaluable. At the time of our analysis, the median follow-up for the entire group was 120 months (range, 4 to 169 months).


RESULTS
The 10-year PFS results for the ABVD, BEACOPP, and CEC arms were 69%, 75%, and 76%, respectively; corresponding OS results were 85%, 84%, and 86%. Overall, 13 second malignancies were reported: one in the ABVD arm and six each in the BEACOPP and CEC arms. The cumulative risk of developing second malignancies at 10 years was 0.9%, 6.6%, and 6% with ABVD, BEACOPP, and CEC, respectively; the risk with either BEACOPP or CEC was significantly higher than that reported with ABVD (P = .027 and .02, respectively).


CONCLUSION
With these mature results, we confirm that patients with advanced Hodgkin lymphoma have similar OS results when treated with ABVD, BEACOPP, or CEC. However, with longer follow-up, we were not able to confirm the superiority of BEACOPP over ABVD in terms of PFS, mainly because of higher mortality rates resulting from second malignancies observed after treatment with BEACOPP and CEC.
Optical PPM synchronization for photon counting receivers

The performance of two signal synchronization schemes for photon counting receivers used in optical PPM communication systems operating in low-flux conditions, such as proposed deep space optical communication links, are analyzed. The pilot symbol insertion and inter-symbol guard time synchronization schemespsila performance are compared under conditions of equal throughput and equal peak or average power at representative operating points, including frequency offset due to transmit and receiver oscillator instability.
Effects of Community-Based Cardiac Rehabilitation on Body Composition and Physical Function in Individuals with Stable Coronary Artery Disease: 1.6-Year Followup

OBJECTIVE
To examine long-term changes in physical function and body composition in coronary artery disease (CAD) patients participating in ongoing community-based cardiac rehabilitation (CR).


DESIGN
Thirty-four individuals (69.7 ± 8.2 years; 79% men) participated in this longitudinal observational study. Baseline and follow-up assessments included incremental shuttle walk, short physical performance battery, handgrip strength, chair stands, body composition, last year physical activity, and CR attendance.


RESULTS
Participants attended 38.5 ± 30.3% sessions during 1.6 ± 0.2 year followup. A significant increase in 30-second chair stands (17.0 ± 4.7 to 19.6 ± 6.4, P < 0.001), body weight (75.8 ± 11.1 to 77.2 ± 12.1 kg, P = 0.001), and body fat (27.0 ± 9.5 to 29.1 ± 9.6%, P < 0.001) and a decline in handgrip strength (36.4 ± 9.4 to 33.0 ± 10.6 kg·f, P < 0.001) and muscle mass (40.8 ± 5.6 to 39.3 ± 5.8%, P < 0.001) were observed during followup. There was no significant change in shuttle walk duration. CR attendance was not correlated to observed changes.


CONCLUSIONS
Elderly CAD patients participating in a maintenance CR program improve lower-body muscle strength but experience a decline in handgrip strength and unfavourable changes in body composition, irrespective of CR attendance.