LLukas22/scidocs huggingface dataset:
Noninferiority of a task-shifting HIV care and treatment model using peer counselors and nurses among Ugandan women initiated on ART: evidence from a randomized trial.

OBJECTIVE
To assess the noninferiority of a task-shifting HIV treatment model relying on peer counselors and nurses compared with a physician-centered model among HIV-1-positive women initiated on antiretroviral therapy (ART) at a prevention of mother-to-child transmission clinic in Mulago Hospital, Uganda.


METHODS
HIV-1-infected ART eligible naive women were randomized to either nurse-peer (intervention) or doctor-counselor (standard model) arm. The primary endpoint was virologic success defined attaining a viral load < 400 RNA copies per milliliter 6-12 months after ART initiation. Noninferiority was defined as the lower 95% confidence limit for the difference in proportions with virologic success being less than 10%. Secondary outcomes included immunologic success (mean CD4 count increase from baseline) and pill count.


RESULTS
Data on 85 participants were analyzed (n = 45 in the intervention and n = 40 in the standard model). The proportion of participants with virologic success was similar in the standard and intervention models [91% versus 88% respectively; difference, 3%; 95% confidence interval (CI): -11% to 12%]. Probability of viral detection at 6-12 months' time point was similar in the 2 models (log-rank test P = 0.73). Immunologic and pill count indicators were also similar in the intervention and standard models, with mean CD4 increase of 217 versus 206 cells per microliter (difference, 11; 95% CI: -60 to 82 cells/μL) and pill counts of 99.8% versus 99.7% (difference, 0.0; 95% CI: -5% to 5%) respectively.


CONCLUSIONS
Nurses and peer counselors were not inferior in providing ART follow-up care to postpartum women, an approach that may help deliver treatment to many more HIV-infected people.
Mutualism between the territorial intertidal limpet Patella longicosta and the crustose alga Ralfsia verrucosa

Mutualistic relations between plants and animals are well documented on land but have received less attention in marine systems. This study examined the relationship between the territorial intertidal limpet Patella longicosta and the crustose brown alga Ralfsia verrucosa. Adult Patella are found exclusively in association with Ralfsia, on which they feed, while Ralfsia occurs primarily, but not exclusively, in Patella territories. Ralfsia benefits directly from both the presence and the territorial behaviour of Patella. Algal productivity was assessed by measuring oxygen evolution and utilization in situ and deriving photosynthesis/irradiance curves. Productivity was increased by about 30% by the presence of Patella in both summer (P max of grazed algae 0.0098; ungrazed algae 0.0063 mg C · cm-2 · h-1) and winter (P max grazed algae 0.0081; ungrazed algae 0.0053 mg-2 · C · h-1). Algal growth rates were not significantly increased by the application of limpet mucus in the laboratory. We did not examine nutrient regeneration by the limpet, but the increase in photosynthetic rate may depend on the limpet's grazing pattern which creates secondary sites for growth. Ralfsia also benefited from the territorial behaviour of Patella. The effects of different grazing regimes were investigated in different seasons by removing territorial limpets and either excluding all limpets using copper-based antifouling paint, or allowing access to non-territorial limpets (mostly P. oculus) using partial paint barriers. Exclusion of all limpets resulted in rapid overgrowth of Ralfsia plants by the foliose green alga Ulva sp.. Where non-territorial limpets had access to the plants overgrowth was reduced but Ralfsia plants were entirely removed by destructive grazing. Non-territorial grazers removed 90% of Ralfsia plants within 4 weeks in summer and 60% in winter. In control treatments P. longicosta prevented overgrowth by Ulva and actively excluded vagrant grazers, preventing overgrazing. Based on these findings, the association between the limpet and alga can be regarded as a nonobligate mutualism.
A phase I study with an expanded cohort to assess feasibility of intravenous docetaxel, intraperitoneal carboplatin and intraperitoneal paclitaxel in patients with previously untreated ovarian, fallopian tube or primary peritoneal carcinoma: a Gynecologic Oncology Group study.

OBJECTIVE
To define the maximum tolerated dose (MTD) and assess the feasibility of intravenous (IV) docetaxel, intraperitoneal (IP) carboplatin and IP paclitaxel in women with stage II-IV untreated ovarian, fallopian tube or primary peritoneal carcinoma.


METHODS
Patients received docetaxel (55-75 mg/m(2)) IV and carboplatin (AUC 5-7) IP on day 1 and paclitaxel 60 mg/m(2) IP on day 8. A standard 3+3 design was used in the dose escalation phase. A 2-stage group sequential design with 20 patients at the MTD was used in the feasibility phase.


RESULTS
The MTD determined during the dose escalation phase was day 1 docetaxel 75 mg/m(2) IV, carboplatin AUC 6 IP and day 8 IP paclitaxel 60 mg/m(2). Forty-six patients were enrolled in the feasibility portion at this dose level. Six were unevaluable. Fifteen evaluable patients had dose-limiting toxicities (DLTs) within the first four cycles. These DLTs were prolonged neutropenia (2), neutropenic fever (7), grade 4 thrombocytopenia (1), grade 4 dehydration (1), grade 3 infection (2), grade 3 oral mucositis (1) and pulmonary embolism (1).


CONCLUSIONS
Docetaxel 75 mg/m(2) IV, carboplatin AUC 6 IP administered on day 1, and paclitaxel 60 mg/m(2) IP administered on day 8, is the MTD when considering one cycle of treatment but was not feasible over four cycles due to bone marrow toxicity. We recommend reduction of carboplatin to AUC 5 should this regimen be considered for treatment in women with newly diagnosed advanced ovarian cancer.
A process model to estimate biodiesel production costs.

'Biodiesel' is the name given to a renewable diesel fuel that is produced from fats and oils. It consists of the simple alkyl esters of fatty acids, most typically the methyl esters. We have developed a computer model to estimate the capital and operating costs of a moderately-sized industrial biodiesel production facility. The major process operations in the plant were continuous-process vegetable oil transesterification, and ester and glycerol recovery. The model was designed using contemporary process simulation software, and current reagent, equipment and supply costs, following current production practices. Crude, degummed soybean oil was specified as the feedstock. Annual production capacity of the plant was set at 37,854,118 l (10 x 10(6)gal). Facility construction costs were calculated to be US dollar 11.3 million. The largest contributors to the equipment cost, accounting for nearly one third of expenditures, were storage tanks to contain a 25 day capacity of feedstock and product. At a value of US dollar 0.52/kg (dollar 0.236/lb) for feedstock soybean oil, a biodiesel production cost of US dollar 0.53/l (dollar 2.00/gal) was predicted. The single greatest contributor to this value was the cost of the oil feedstock, which accounted for 88% of total estimated production costs. An analysis of the dependence of production costs on the cost of the feedstock indicated a direct linear relationship between the two, with a change of US dollar 0.020/l (dollar 0.075/gal) in product cost per US dollar 0.022/kg (dollar 0.01/lb) change in oil cost. Process economics included the recovery of coproduct glycerol generated during biodiesel production, and its sale into the commercial glycerol market as an 80% w/w aqueous solution, which reduced production costs by approximately 6%. The production cost of biodiesel was found to vary inversely and linearly with variations in the market value of glycerol, increasing by US dollar 0.0022/l (dollar 0.0085/gal) for every US dollar 0.022/kg (dollar 0.01/lb) reduction in glycerol value. The model is flexible in that it can be modified to calculate the effects on capital and production costs of changes in feedstock cost, changes in the type of feedstock employed, changes in the value of the glycerol coproduct, and changes in process chemistry and technology.
FINANCIAL MARKET CONTAGION IN THE ASIAN CRISIS

This paper tests for evidence of contagion between the financial markets of Thailand, Malaysia, Indonesia, Korea, and the Philippines. We find that correlations in currency and sovereign spreads increase significantly during the crisis period, whereas the equity market correlations offer mixed evidence. We construct a set of dummy variables using daily news to capture the impact of own-country and cross-border news on the markets. We show that after controlling for owncountry news and other fundamentals, there is evidence of cross-border contagion in the currency and equity markets. [JEL F30, F40, G15]
Changes in environmental tobacco smoke exposure and asthma morbidity among urban school children.

BACKGROUND
Environmental tobacco smoke (ETS) exposure is associated with poor asthma outcomes in children. However, little is known about natural changes in ETS exposure over time in children with asthma and how these changes may affect health-care utilization. This article documents the relationship between changes in ETS exposure and childhood asthma morbidity among children enrolled in a clinical trial of supervised asthma therapy.


METHODS
Data for this analysis come from a large randomized clinical trial of supervised asthma therapy in which 290 children with persistent asthma were randomized to receive either usual care or supervised asthma therapy. No smoking cessation counseling or ETS exposure education was provided to caregivers; however, children were given 20 min of asthma education, which incorporated discussion of the avoidance of asthma triggers, including ETS. Asthma morbidity and ETS exposure data were collected from caregivers via telephone interviews at baseline and at the 1-year follow-up.


RESULTS
At baseline, 28% of caregivers reported ETS exposure in the home and 19% reported exposure outside of the primary household only. Among children whose ETS exposure decreased from baseline, fewer hospitalizations (p = 0.034) and emergency department (ED) visits (p < or = 0.001) were reported in the 12 months prior to the second interview compared to the 12 months prior to the first interview. Additionally, these children were 48% less likely (p = 0.042) to experience an episode of poor asthma control (EPAC).


CONCLUSIONS
This is the first study to demonstrate an association between ETS exposure reduction and fewer EPACs, respiratory-related ED visits, and hospitalizations. These findings emphasize the importance of ETS exposure reduction as a mechanism to improve asthma control and morbidity. Potential policy implications include supporting ETS reductions and smoking cessation interventions for parents and caregivers of children with asthma. Research to identify the most cost-effective strategy is warranted.
Title of Document : CONCUSSION : EXAMINING THE EFFECT OF NEURONAL OXIDATIVE STRESS ON THE PATHOPHYSIOLOGY OF BRAIN AND BLOOD BRAIN BARRIER CELLS

Neuronal stretching during concussion alters glucose transport and reduces neuronal viability, also affecting other cells in the brain and the Blood Brain Barrier (BBB). Our hypothesis is that oxidative stress (OS) generated in neurons during concussions contributes to this outcome. To validate this, we investigated: (1) whether OS independently causes alterations in brain and BBB cells, namely human neuron-like, neuroblastoma cells (NCs), astrocyte cells (ACs) and brain microvascular endothelial cells (ECs), and (2) whether OS originated in NCs (as in concussion) is responsible for causing the subsequent alterations observed in ACs and ECs. We used H2O2 treatment to mimic OS, validated by examining the resulting reactive oxygen species, and evaluated alterations in cell morphology, expression and localization of the glucose transporter GLUT1, and the overall cell viability. Our results showed that OS, either directly affecting each cell type or originally affecting NCs, caused changes in several morphological parameters (surface area, Feret diameter, circularity, inter-cellular distance), slightly varied GLUT1 expression and lowered the overall cell viability of all NCs, ACs, and ECs. Therefore, we can conclude that oxidative stress, which is known to be generated during concussion, caused alterations in NCs, ACs, and ECs whether independently originated in each cell or when originated in the NCs and could further propagate the ACs and ECs. CONCUSSION: EXAMINING THE EFFECT OF NEURONAL OXIDATIVE STRESS ON THE PATHOPHYSIOLOGY OF BRAIN AND BLOOD BRAIN BARRIER CELLS
Determinants of quality of life in type 2 diabetes population: the inclusion of personality

The identification of factors that affect quality of life (QoL) is crucial to ameliorate the increasing burden of diabetes. This study tested a multi-dimensional model that consisted of factors across three domains (personal, medical, and lifestyle factors) to understand determinants of QoL in adults with type 2 diabetes. A total of 1,147 adults with type 2 diabetes completed a self-report survey which assessed demographic factors, personality (activity sub-trait), medical factors (diabetes duration, insulin use, number of comorbidities, and Body Mass Index), lifestyle behaviors (smoking, physical activity, and diet), and two indicators of QoL [i.e., health-related quality of life (HRQL) and life satisfaction (LS)]. The model explained 27.1 and 18.2% of the variance for HRQL and LS, respectively. Age was positively related to HRQL (β = 0.14, P < 0.01). Personality (sub-activity trait) was the strongest, independent variable in both HRQL (β = 0.25, P < 0.01) and LS (β = 0.25, P < 0.01) after controlling for demographic, medical, and lifestyle factors. Physical activity was positively associated (β = 0.14, P < 0.01) with HRQL but not with LS. Personality may be a useful screening tool to distinguish adults with type 2 diabetes who are at risk for poor QoL.
Treatment Interruption after Pregnancy: Effects on Disease Progression and Laboratory Findings

OBJECTIVE
To assess clinical progression and inflammatory markers among women stopping or continuing antiretroviral therapy (ART) after pregnancy.


METHODS
ART-naïve women with CD4+ lymphocyte counts >350 cells/uL initiating ART during pregnancy had clinical events and laboratory markers compared over one year postpartum between those stopping (n = 59) or continuing (n = 147) ART.


RESULTS
Slopes in CD4 count and HIV RNA did not differ between groups overall and in subsets of ZDV or combination therapy. The hazard ratio (HR) of a new class B event was 2.09 (95% CI 0.79-5.58) among women stopping ART, 1.24 (0.31-4.95) in those stopping ZDV, and 2.93 (0.64-13.36) among those stopping combination therapy. Women stopping ART had increased immune activation. No significant differences were seen in C-reactive protein, lipids, leptin, or interleukin-6.


CONCLUSIONS
While changes in CD4 and HIV RNA levels over one year were similar between women stopping or continuing ART postpartum, higher immune activation among women stopping therapy requires further study.
Cardiac Valve Noise Reduction by Non-Drug Interventions Improves the Sleep Quality of Patients after Mechanical Cardiac Valve Implantation.

PURPOSE
To investigate the effects of non-drug interventions on the sleep quality of patients after mechanical cardiac valve implantation.


METHODS
In this prospective, randomized, controlled trial, 64 patients scheduled for mechanical mitral valve replacement were recruited. Patients underwent cognitive behavioral therapy and wore noise cancelling earplugs and eye mask. Sleep quality was evaluated on the 4th after admission and the 5th days after operation. The primary outcome was the total sleep quality score differences between the 4th day after admission and the 5th day after operation.


RESULTS
All patients had been suffering from poor sleep quality for a month before admission. There was no difference between both groups on the 4th day after admission. Overall sleep quality in the intervention group was better than in the control group on the 5th day after operation. The subjective sleep quality of the patients in each group was significantly lower on the 5th day after the operation than on the 4th day after admission (P <0.05).


CONCLUSION
Non-drug intervention could improve the sleep quality of patients after mechanical cardiac valve implantation and help the postoperative recovery of the patients. (


TRIAL REGISTRATION
ChiCTR-TRC-14004405, 21 March 2014.).
Example-based synthesis of 3D object arrangements

We present a method for synthesizing 3D object arrangements from examples. Given a few user-provided examples, our system can synthesize a diverse set of plausible new scenes by learning from a larger scene database. We rely on three novel contributions. First, we introduce a probabilistic model for scenes based on Bayesian networks and Gaussian mixtures that can be trained from a small number of input examples. Second, we develop a clustering algorithm that groups objects occurring in a database of scenes according to their local scene neighborhoods. These contextual categories allow the synthesis process to treat a wider variety of objects as interchangeable. Third, we train our probabilistic model on a mix of user-provided examples and relevant scenes retrieved from the database. This mixed model learning process can be controlled to introduce additional variety into the synthesized scenes. We evaluate our algorithm through qualitative results and a perceptual study in which participants judged synthesized scenes to be highly plausible, as compared to hand-created scenes.
Transport layer protocols and architectures for satellite networks

Designing efficient transmission mechanisms for advanced satellite networks is a demanding task, requiring the definition and the implementation of protocols and architectures well suited to this challenging environment. In particular, transport protocols performance over satellite networks is impaired by the characteristics of the satellite radio link, specifically by the long propagation delay and the possible presence of segment losses due to physical channel errors. The level of impact on performance depends upon the link design (type of constellation, link margin, coding and modulation) and operational conditions (link obstructions, terminal mobility, weather conditions, etc.). To address these critical aspects a number of possible solutions have been presented in the literature, ranging from limited modifications of standard protocols (e.g. TCP, transmission control protocol) to completely alternative protocol and network architectures. However, despite the great number of different proposals (or perhaps also because of it), the general framework appears quite fragmented and there is a compelling need of an integration of the research competences and efforts. This is actually the intent of the transport protocols research line within the European SatNEx (Satellite Network of Excellence) project. Stemming from the authors’ work on this project, this paper aims to provide the reader with an updated overview of all the possible approaches that can be pursued to overcome the limitations of current transport protocols and architectures, when applied to satellite communications. In the paper the possible solutions are classified in the following categories: optimization of TCP interactions with lower layers, TCP enhancements, performance enhancement proxies (PEP) and delay tolerant networks (DTN). Advantages and disadvantages of the different approaches, as well as their interactions, are investigated and discussed, taking into account performance improvement, complexity, and compliance to the standard semantics. From this analysis, it emerges that DTN architectures could integrate some of the most efficient solutions from the other categories, by inserting them in a new rigorous framework. These innovative architectures therefore may represent a promising solution for solving some of the important problems posed at the transport layer by satellite networks, at least in a medium-tolong-term perspective. Copyright # 2006 John Wiley & Sons, Ltd.
Fatal Naegleria fowleri Meningoencephalitis, Italy

We report the first case of primary amebic meningoencephalitis in Italy, in a 9-year-old boy. Clinical course was fulminant, and diagnosis was made by identifying amebas in stained brain sections and by indirect immunofluorescence analysis. Naegleria fowleri was characterized as genotype I on the basis of polymerase chain reaction test results.
Compact broadband transition from double-ridge waveguide to coaxial line for phased array feed

This paper discloses a new very broadband compact transition between double-ridge waveguide and coaxial line. The transition includes an original waveguide to coaxial mode converter and modified impedance transformer. Very good performance is predicted theoretically and confirmed experimentally over a 3:1 bandwidth.
Creation of a Local Interface Terminology to SNOMED CT

This paper describes the steps followed in the creation of a local Interface Terminology to SNOMED CT (as reference terminology) with a strong focus on user acceptability. The resulting list of terms is used for clinical data input by physicians and nurses at the Hospital Italiano in Buenos Aires, Argentina. Description includes data model, mappings to SNOMED CT and classifications, subsets definitions and extensibility mechanisms. The Interface Terminology is currently used in the recording of diagnosis and procedures in inpatient discharge summaries and its coverage is improving from user feedback. Its current size is 24,800 concepts, 67% of them needed post-coordination for appropriate semantic representation, due to a very flexible policy that allows the use of any number of modifiers on concepts.
Multiscale simulations of primary atomization

A liquid jet upon atomization breaks up into small droplets that are orders of magnitude smaller than its diameter. Direct numerical simulations of atomization are exceedingly expensive computationally. Thus, the need to perform multiscale simulations. In the present study, we performed multiscale simulations of primary atomization using a Volume-of-Fluid (VOF) algorithm coupled with a two-way coupling Lagrangian particle-tracking model to simulate the motion and influence of the smallest droplets. Collisions between two particles are efficiently predicted using a spatial-hashing algorithm. The code is validated by comparing the numerical simulations for the motion of particles in several vortical structures with analytical solutions. We present simulations of the atomization of a liquid jet into droplets which are modeled as particles when away from the primary jet. We also present the probability density function of the droplets thus obtained and show the evolution of the PDF in space.
Implementing Intelligent Traffic Control System for Congestion Control , Ambulance Clearance , and Stolen Vehicle Detection

In this paper, we proposed an Implementing Intelligent Traffic Control for Congestion, Ambulance clearance, and Stolen Vehicle Detection. This system was implemented based on present criteria that tracking three conditions in those one is heavy traffic control and another one is making a root of emergency vehicle like ambulance and VIP vehicle. In this paper we are going to implement a sensor network work which is used to detect the traffic density and also use RFID reader and tags. We use ARM7 system-on-chip to read the RFID tags attached to the vehicles. It counts number of vehicles that passes on a particular path during a specified duration. If the RFID tag read belongs to the stolen vehicles. GSM SIM300 used for message send to the police control room. In addition, when an ambulance approaching the junction, it will communicate the traffic controller in the junction to turn on the green light. This module uses Zigbee modules on CC2500. Keywords— ZigBee, CC2500, GSM, SIM300, ARM-9, ambulance vehicle stolen vehicle, congestion control, traffic junction.