LLukas22/scidocs huggingface dataset:
How do symbolic and non-symbolic numerical magnitude processing skills relate to individual differences in children's mathematical skills? A review of evidence from brain and behavior

• NOTICE: this is the author's version of a work that was accepted for publication in Trends in Neuroscience and Education. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Trends in Neuroscience and Education, 2 (2), 2013, DOI: 10.1016/j.tine.2013.06.001
The Role of the Paramedic Practitioner in the UK

The ‘Paramedic Practitioner’ role has developed against a background of change in primary care service provision, apparently resulting in an increasing utilisation of emergency ambulance services. This presents opportunities to extend the scope of practice of paramedics and other health professionals in the diagnosis and management of patients with minor illnesses and injuries. Such patients commonly present via calls to traditional emergency numbers (999) or are referred from other unscheduled care agencies. Paramedic practitioners can reduce the number of patients inappropriately transported to hospital by approximately half, thus meeting an NHS aim of ‘treating the right patients in the right place at the right time’. Other opportunities exist in the form of extended roles in critical care and the management of the chronically ill in the community. Currently, a number of pilot programmes exist but vary considerably with respect to type and duration of training, permitted scope of practice, and even the job title of these new practitioners. To be successful, these major changes in the role of ambulance professionals will require the paramedic profession to take leadership through its own professional body (the British Paramedic Association (BPA) in the establishment of defined standards of practice. A shift from vocational training to university-based education will be necessary to meet the intellectual demands of the autonomous management of these patient populations. Uniformity of job title and legal restrictions on its use are also required. These new opportunities for practice will offer a structured clinical career for ambulance professionals for the first time. The BPA has proposed that Emergency Medical Technicians will have a university Certificate; paramedics a university Diploma; paramedic practitioners an Honours Degree; and advanced paramedic practitioners a Masters Degree. Consultant paramedics holding PhDs will support their peers in furthering professional practice. The ambulance profession is coming of age...
Hospital care of osteoporosis-related vertebral fractures

 Resource implications of hospitalization for osteoporosis-related vertebral fracture are sparsely documented. This study utilized data abstracted from a national sample of hospitalized patients to identify characteristics of patients who are hospitalized with vertebral fracture and their patterns of resource utilization. These were compared with patterns observed for hip fracture hospitalizations. Data from the Nationwide Inpatient Sample (NIS) for 1997 were used to identify men and women age 45 years and above who had a primary diagnosis of vertebral fracture. After patients whose fractures might have been due to metastatic cancer or severe trauma were excluded, 68 901 individuals hospitalized for vertebral fracture were identified. Seventy-seven percent of these were women, most were white, 75 years and older, and had multiple comorbid diagnoses. Total charges averaged US$8000–10 000 per hospitalization and were higher in men. Mean length of stay was just under 6 days and more than 50% of discharged patients required some form of continuing care. Hospitalizations for vertebral fracture occurred at only one-fourth the rate of those for hip fracture, and created only half the hospital charges per admission. Vertebral fracture accounted for over 400 000 total hospital days and generated charges in excess of US$500 million. This resource impact is considerably higher than has been described in prior studies.
Factors that influence radioactive iodine use for thyroid cancer.

BACKGROUND
There is variation in the use of radioactive iodine (RAI) as treatment for well-differentiated thyroid cancer. The factors involved in physician decision-making for RAI remain unknown.


METHODS
We surveyed physicians involved in postsurgical management of patients with thyroid cancer from 251 hospitals. Respondents were asked to rate the factors important in influencing whether a thyroid cancer patient receives RAI. Multivariable analyses controlling for physician age, gender, specialty, case volume, and whether they personally administer RAI, were performed to determine correlates of importance placed on patients' and physicians' worry about death from cancer and differences between low- versus higher-case-volume physicians.


RESULTS
The survey response rate was 63% (534/853). Extent of disease, adequacy of surgical resection, patients' willingness to receive RAI, and patients' age were the factors physicians were most likely to report as quite or very important in influencing recommendations for RAI to patients with thyroid cancer. Interestingly, both physicians' and patients' worry about death from thyroid cancer were also important in determining RAI use. Physicians with less thyroid cancer cases per year were more likely than higher-volume physicians to report patients' (p<0.001) and physicians' worry about death (p=0.016) as quite or very important in decision-making. Other factors more likely to be of greater importance in determining RAI use for physicians with lower thyroid cancer patient volume versus higher include the accepted standard at the affiliated hospital (p=0.020), beliefs about RAI expressed by colleagues comanaging patients (p=0.003), and patient distance from the nearest facility administering RAI (p=0.012).


CONCLUSION
In addition to the extent of disease and adequacy of surgical resection, physicians place importance on physician and patient worry about death from thyroid cancer when deciding whether to treat a patient with RAI. The factors important to physician decision-making differ based on physician thyroid-cancer case-volume, with worry about death being more influential for low-case-volume physicians. As the mortality from thyroid cancer is low, the importance placed on death in decision making may be unwarranted.
Coming of Age: A Longitudinal Study of TLS Deployment

The Transport Layer Security (TLS) protocol is the de-facto standard for encrypted communication on the Internet. However, it has been plagued by a number of different attacks and security issues over the last years. Addressing these attacks requires changes to the protocol, to server- or client-software, or to all of them. In this paper we conduct the first large-scale longitudinal study examining the evolution of the TLS ecosystem over the last six years. We place a special focus on the ecosystem's evolution in response to high-profile attacks.
 For our analysis, we use a passive measurement dataset with more than 319.3B connections since February 2012, and an active dataset that contains TLS and SSL scans of the entire IPv4 address space since August 2015. To identify the evolution of specific clients we also create the---to our knowledge---largest TLS client fingerprint database to date, consisting of 1,684 fingerprints.
 We observe that the ecosystem has shifted significantly since 2012, with major changes in which cipher suites and TLS extensions are offered by clients and accepted by servers having taken place. Where possible, we correlate these with the timing of specific attacks on TLS. At the same time, our results show that while clients, especially browsers, are quick to adopt new algorithms, they are also slow to drop support for older ones. We also encounter significant amounts of client software that probably unwittingly offer unsafe ciphers. We discuss these findings in the context of long tail effects in the TLS ecosystem.
Effects of lansoprazole plus amoxycillin on the cure of Helicobacter pylori infection in Japanese peptic ulcer patients.

AIM
The effect of lansoprazole plus amoxycillin on curing Helicobacter pylori infection and peptic ulcer recurrence was evaluated.


METHOD
The study group was composed of 68 patients with gastric ulcers and 51 with duodenal ulcers, all were H. pylori-positive. The participants were assigned at random to the lansoprazole alone group (lansoprazole 30 mg o.m. for 6 or 8 weeks) or the lansoprazole plus amoxycillin group (lansoprazole alone regimen plus amoxycillin at 500 mg q.d.s. concomitantly for the first 2 weeks). Healed patients were not given maintenance treatment with acid secretion inhibitors. The cure rate for H. pylori infection and the ulcer recurrence rate after 1 year were investigated.


RESULT
The cure rate for H. pylori infection was 4.2% in patients receiving lansoprazole alone and 38.5% in patients receiving lansoprazole plus amoxycillin (P < 0.01) for gastric ulcers, and 0% in patients receiving lansoprazole alone and 61.9% in patients receiving lansoprazole plus amoxycillin (P < 0.001) for duodenal ulcers. The recurrence rate was 42.3% in patients receiving lansoprazole alone and 28.6% in patients receiving lansoprazole plus amoxycillin for gastric ulcers, and 66.7% for patients receiving lansoprazole alone and 11.1% for patients receiving lansoprazole plus amoxycillin (P < 0.001) for duodenal ulcers. None of the patients with gastric or duodenal ulcers cured of H. pylori infection had a recurrence.


CONCLUSION
Concomitant use of lansoprazole and amoxycillin increased the curative effects on H. pylori infection. However, the cure rates with this regimen remained inadequate.
Effect of a Low–Resource-Intensive Lifestyle Modification Program Incorporating Gymnasium-Based and Home-Based Resistance Training on Type 2 Diabetes Risk in Australian Adults 

OBJECTIVE
The purpose of this study was to assess the effectiveness of a low-resource-intensive lifestyle modification program incorporating resistance training and to compare a gymnasium-based with a home-based resistance training program on diabetes diagnosis status and risk.


RESEARCH DESIGN AND METHODS
A quasi-experimental two-group study was undertaken with 122 participants with diabetes risk factors; 36.9% had impaired glucose tolerance (IGT) or impaired fasting glucose (IFG) at baseline. The intervention included a 6-week group self-management education program, a gymnasium-based or home-based 12-week resistance training program, and a 34-week maintenance program. Fasting plasma glucose (FPG) and 2-h plasma glucose, blood lipids, blood pressure, body composition, physical activity, and diet were assessed at baseline and week 52.


RESULTS
Mean 2-h plasma glucose and FPG fell by 0.34 mmol/l (95% CI -0.60 to -0.08) and 0.15 mmol/l (-0.23 to -0.07), respectively. The proportion of participants with IFG or IGT decreased from 36.9 to 23.0% (P = 0.006). Mean weight loss was 4.07 kg (-4.99 to -3.15). The only significant difference between resistance training groups was a greater reduction in systolic blood pressure for the gymnasium-based group (P = 0.008).


CONCLUSIONS
This intervention significantly improved diabetes diagnostic status and reduced diabetes risk to a degree comparable to that of other low-resource-intensive lifestyle modification programs and more intensive interventions applied to individuals with IGT. The effects of home-based and gymnasium-based resistance training did not differ significantly.
Psychosocial interventions for adults with visible differences: a systematic review

UNLABELLED
Background. Some individuals with visible differences have been found to experience psychosocial adjustment problems that can lead to social anxiety and isolation. Various models of psychosocial intervention have been used to reduce social anxiety and appearance related distress in this population. The objective of this review was to update a previous systematic review assessing the efficacy of psychosocial intervention programs for adults with visible differences. The original review (Bessell & Moss, 2007) identified 12 papers for inclusion. Methods. A search protocol identified studies from 13 electronic journal databases.


METHODS
Studies were selected in accordance with pre-set inclusion criteria and relevant data were extracted. Results. This update identified an additional four papers that met the inclusion criteria. Two papers provided very limited evidence for the efficacy of a combined cognitive-behavioural and social skills training approach. None of the papers provided sufficient evidence for the optimal duration, intensity or setting of psychosocial interventions for this population. Discussion. The review concluded that a greater number of Randomised Controlled Trials and experimental studies were required to increase the methodological validity of intervention studies.
SOCIAL RESPONSIBILITY AND STRATEGIC MANAGEMENT : TOWARD AN ENTERPRISE STRATEGY CLASSIFICATION

Corporate social responsibility is incorporated into strategic management at the enterprise strategy level. This paper delineates the domain of enterprise strategy by focusing on how well a firm's social performance matches its competences and stakeholders rather than on the "quantity" of a firm's social responsibility. Enterprise strategy is defined and a classification of enterprise strategies is set forth.
Nonparametric statistical testing of EEG- and MEG-data

In this paper, we show how ElectroEncephaloGraphic (EEG) and MagnetoEncephaloGraphic (MEG) data can be analyzed statistically using nonparametric techniques. Nonparametric statistical tests offer complete freedom to the user with respect to the test statistic by means of which the experimental conditions are compared. This freedom provides a straightforward way to solve the multiple comparisons problem (MCP) and it allows to incorporate biophysically motivated constraints in the test statistic, which may drastically increase the sensitivity of the statistical test. The paper is written for two audiences: (1) empirical neuroscientists looking for the most appropriate data analysis method, and (2) methodologists interested in the theoretical concepts behind nonparametric statistical tests. For the empirical neuroscientist, a large part of the paper is written in a tutorial-like fashion, enabling neuroscientists to construct their own statistical test, maximizing the sensitivity to the expected effect. And for the methodologist, it is explained why the nonparametric test is formally correct. This means that we formulate a null hypothesis (identical probability distribution in the different experimental conditions) and show that the nonparametric test controls the false alarm rate under this null hypothesis.
Cost of Delivering Health Care Services in Public Sector Primary and Community Health Centres in North India

BACKGROUND
With the commitment of the national government to provide universal healthcare at cheap and affordable prices in India, public healthcare services are being strengthened in India. However, there is dearth of cost data for provision of health services through public system like primary & community health centres. In this study, we aim to bridge this gap in evidence by assessing the total annual and per capita cost of delivering the package of health services at PHC and CHC level. Secondly, we determined the per capita cost of delivering specific health services like cost per antenatal care visit, per institutional delivery, per outpatient consultation, per bed-day hospitalization etc.


METHODS
We undertook economic costing of fourteen public health facilities (seven PHCs and CHCs each) in three North-Indian states viz., Haryana, Himachal Pradesh and Punjab. Bottom-up costing method was adopted for collection of data on all resources spent on delivery of health services in selected health facilities. Analysis was undertaken using a health system perspective. The joint costs like human resource, capital, and equipment were apportioned as per the time value spent on a particular service. Capital costs were discounted and annualized over the estimated life of the item. Mean annual costs and unit costs were estimated along with their 95% confidence intervals using bootstrap methodology.


RESULTS
The overall annual cost of delivering services through public sector primary and community health facilities in three states of north India were INR 8.8 million (95% CI: 7,365,630-10,294,065) and INR 26.9 million (95% CI: 22,225,159.3-32,290,099.6), respectively. Human resources accounted for more than 50% of the overall costs at both the level of PHCs and CHCs. Per capita per year costs for provision of complete package of preventive, curative and promotive services at PHC and CHC were INR 170.8 (95% CI: 131.6-208.3) and INR162.1 (95% CI: 112-219.1), respectively.


CONCLUSION
The study estimates can be used for financial planning of scaling up of similar health services in the urban areas under the aegis of National Health Mission. The estimates would be also useful in undertaking equity analysis and full economic evaluations of the health systems.
Protocol for assessing the hypotensive effect of evening administration of acetylsalicylic acid: study protocol for a randomized, cross-over controlled trial

BACKGROUND
The objective of this study is to evaluate the antihypertensive effect of bedtime administration of low doses of aspirin in patients with treated hypertension and high cardiovascular risk on low-dose aspirin for secondary prevention, in order to optimize their usual treatment and reduce their cardiovascular risk.


METHODS/DESIGN
This is a prospective phase IV multicentre, randomised, triple-blind, placebo-controlled, cross-over clinical trial. We will include 258 individuals with hypertension treated with low-dose aspirin for secondary prevention. These patients will be randomly recruited, by approximately 40 primary care physicians collaborating in the study, mainly in the Guipúzcoa West, Bilbao and Barcelona areas. The 258 patients will be randomly allocated to treatments to create two comparable groups. In the first period, the intervention group will take aspirin at night and placebo in the morning, while the control group will take their aspirin in the morning and placebo in the evening for 2 months. After a washout period of 15 to 30 days, there will be a second 2-month period for which groups will swap treatments. Participants will undergo ambulatory blood pressure monitoring at baseline, at the end of first period and then again at the beginning and end of the second period. The main outcome measure is the change in mean blood pressure over 24 h, and as secondary outcomes we will also assess changes in systolic and diastolic blood pressure, during the day and night, and the relationship between them. Lastly, we will explore whether non-dipper patients convert into dippers with the intervention.


DISCUSSION
The goal of this research is to provide the scientific basis for indicating a change in the time of aspirin administration from morning to evening, by primary health practitioners, to improve the patient control of blood pressure and more effectively reduce their cardiovascular risk, by combining this hypotensive effect with the well-known anti-platelet effect of low-dose aspirin.


TRIAL REGISTRATION
ClinicalTrials.gov NCT01741922.
Pseudoangiomatous Stromal Hyperplasia: A Rare Cause of Idiopathic Gigantomastia

1 Adam J. Oppenheimer, MD Fiala Aesthetics Orlando, Fla. Daniel C. Oppenheimer, MD Department of Imaging Sciences, University of Rochester Rochester, N.Y. Thomas G. S. Fiala, MD Fiala Aesthetics, Altamonte Springs, Fla. Sharon Noori, MD Health First, Department of General Surgery, Holmes Regional Medical Center Melbourne, Fla. Sir: W read with interest Roy et al’s1 case report of a patient with pseudoangiomatous stromal hyperplasia (PASH) causing gigantomastia. We report a similar case in a 29-year-old woman with rapidly progressing macromastia (Fig. 1), who also complained of cyclical breast swelling and multiple palpable breast masses, with biopsy proven PASH. Although we commend the aesthetic result achieved by Roy et al1, we differ in our algorithm. Because of the propensity for PASH to recur and owing to its inherently diffuse involvement within the breast tissues, we opted for a more aggressive approach: bilateral Wise-pattern mastectomy with immediate tissue expander reconstruction. At the time of the mastectomy, several large (5–7 cm) discrete breast masses were identified, one of which was histopathologically consistent with a benign phyllodes tumor (a fibroepithelial stromal tumor with malignant potential).2 Reconstruction proceeded using the Wise pattern: the lower pole of the breast was deepithelialized and used as soft-tissue reinforcement, reapproximating the dermal edge against the cut edge of the pectoralis major muscle, in place of an alloplastic dermal tissue matrix.3 The patient’s expansion proceeded uneventfully, and no chemoradiation was recommended by the institutional tumor board. She underwent expander–implant exchange using 425-cc Sientra (Santa Barbara, Calif.) textured round base anatomic devices bilaterally and is without complications now 3 months postoperatively (Fig. 2). Although PASH is rare, and most commonly a benign clinical entity, there have been reports of malignancy arising within PASH.4 Indeed, in our patient, a phyllodes tumor was found as a synchronous mass. Although benign, this lesion does harbor malignant potential. Furthermore, recurrence rates up to 22% have been reported in the literature for PASH.5 Therefore, we feel that a more aggressive treatment plan is indicated when PASH is identified. Given the abundance of breast skin in these patients, a Wisepattern mastectomy with expander–implant based reconstruction is a viable and aesthetically pleasing option, which also obviates the burdensome need for ongoing oncological surveillance in these patients.
Randomized, placebo-controlled, double-blind study assessing the efficacy and safety of paliperidone palmitate in Asian patients with schizophrenia

BACKGROUND
This 13-week, double-blind study was conducted to confirm the efficacy and safety of paliperidone palmitate (PP), at dosing regimens approved in other countries, in Asian patients with schizophrenia.


METHODS
Asian patients (aged ≥20 years) diagnosed with schizophrenia (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition-Text Revision criteria), and having a Positive and Negative Syndrome Scale (PANSS) total score of 60 to 120 were enrolled and randomized (1:1) to a PP or placebo group. Patients received PP intramuscularly at recommended doses: initiation dose 150 mg equivalent (eq) PP on day 1 and 100 mg eq PP on day 8 (deltoid); and a monthly maintenance dose of 75 mg eq PP on days 36 and 64 (deltoid or gluteal). The change from baseline to week 13 in PANSS total scores (primary endpoint), Clinical Global Impression-Severity (CGI-S) scores, and PANSS Marder factor scores and subscales, and responder rate at week 13 were evaluated. Safety was also assessed.


RESULTS
The PANSS total score (P<0.0001, least-squares mean change from baseline to week 13: PP, -3.5; placebo, +6.2), CGI-S score (P<0.0001), and PANSS Marder factor scores (P≤0.0025) were significantly improved at week 13 in the PP group versus placebo. More treatment responders (≥30% decrease in PANSS total score) were in the PP group (22.8%) versus placebo (8.5%). Insomnia (PP 17.0% versus placebo 15.2%), injection site pain (13.2% versus 6.7%), nasopharyngitis (12.6% versus 6.1%), psychiatric symptoms (11.3% versus 26.2%), and extrapyramidal symptoms (10.1% versus 4.9%) were the most frequently occurring treatment-emergent adverse events.


CONCLUSION
PP is efficacious for Asian patients with schizophrenia at the dosing regimen approved in other countries, with a similar safety and tolerability profile.