LLukas22/scidocs huggingface dataset:
A Randomized , Double-Blinded , Placebo-Controlled Phase II Trial of Recombinant Human Leukemia Inhibitory Factor ( rhuLIF , Emfilermin , AM 424 ) to Prevent Chemotherapy-Induced Peripheral Neuropathy

Purpose: To determine whether recombinant human leukemia inhibitory factor (rhuLIF, AM424, emfilermin) can prevent or ameliorate the development of chemotherapyinduced peripheral neuropathy (CIPN) after treatment with carboplatin (AUC 6) and paclitaxel (175 mg/m over 3 hours). Experimental Design: Randomized double-blind placebo-controlled phase II clinical trial. Eligible patients had solid tumors for which treatment with carboplatin/paclitaxel was appropriate. The primary end point was a standardized composite peripheral nerve electrophysiology (CPNE) score, based on nerve velocities and amplitudes, measured at baseline and after four cycles of chemotherapy. Secondary efficacy end points included CPNE score at last cycle and at exit evaluation, vibration perception threshold, H-reflex latency, symptom scores, and quantitative assessment of neurologic signs. Study drug was given s.c. daily for 7 days starting the day before chemotherapy. Patients were randomized to receive low-dose rhuLIF (2 Mg/kg), high-dose rhuLIF (4 Mg/kg), or placebo. Results: Patients (n = 117) were randomized across seven neurology test centers. Thirty-six patients received low dose rhuLIF (2 Mg/kg), 39 received high dose rhuLIF (4 Mg/kg) and 42 received placebo. rhuLIF was well tolerated with 95% compliance and no adverse effects on quality of life. No differences between groups in CPNE or any of the individual neurologic testing variables were observed between baseline and cycle 4 or by the secondary
Evaluating the On-Demand Mobile Charging in Wireless Sensor Networks

Recently, adopting mobile energy chargers to replenish the energy supply of sensor nodes in wireless sensor networks has gained increasing attention from the research community. Different from energy harvesting systems, the utilization of mobile energy chargers is able to provide more reliable energy supply than the dynamic energy harvested from the surrounding environment. While pioneering works on the mobile recharging problem mainly focus on the optimal offline path planning for the mobile chargers, in this work, we aim to lay the theoretical foundation for the on-demand mobile charging (DMC) problem, where individual sensor nodes request charging from the mobile charger when their energy runs low. Specifically, in this work, we analyze the on-demand mobile charging problem using a simple but efficient Nearest-Job-Next with Preemption (NJNP) discipline for the mobile charger, and provide analytical results on the system throughput and charging latency from the perspectives of the mobile charger and individual sensor nodes, respectively. To demonstrate how the actual system design can benefit from our analytical results, we present two examples on determining the essential system parameters such as the optimal remaining energy level for individual sensor nodes to send out their recharging requests and the minimal energy capacity required for the mobile charger. Through extensive simulation with real-world system settings, we verify that our analytical results match the simulation results well and the system designs based on our analysis are effective.
Monitoring IgA multiple myeloma: immunoglobulin heavy/light chain assays.

BACKGROUND
The use of electrophoresis to monitor monoclonal immunoglobulins migrating in the β fraction may be difficult because of their comigration with transferrin and complement proteins.


METHODS
Immunoassays specific for IgGκ, IgGλ, IgAκ, IgAλ, IgMκ, and IgMλ heavy/light chain (HLC) were validated for use in the clinical laboratory. We assessed sample stability, inter- and intraassay variability, linearity, accuracy, and reference intervals for all 6 assays. We tested accuracy by verifying that the sum of the concentrations for the HLC-pairs accounted for the total immunoglobulins in each of 129 healthy sera, and that the HLC-pair ratios (rHLCs) were outside the reference interval in 97% of 518 diagnostic multiple myeloma (MM) samples.


RESULTS
We assessed diagnostic samples and posttreatment sera in 32 IgG and 30 IgA patients for HLC concentrations, rHLC, and total immunoglobulins and compared these nephelometry results with serum protein electrophoresis (SPEP) and immunofixation electrophoresis (IFE). In sample sets from patients with IgG MM, the sensitivity of SPEP was almost the same as for rHLC, and no additional advantage was conferred by running HLC assays. In pre- and posttreatment samples from patients with IgA MM, the SPEP, rHLC, and IFE identified clonality in 28%, 56%, and 61%, respectively. In addition, when M-spikes were quantifiable, the concentration of the involved HLC was linearly related to that of the SPEP M-spike, with a slope near 1.


CONCLUSIONS
The use of IgA HLC assays for monitoring β-migrating IgA monoclonal proteins can substitute for the combination of SPEP, IFE, and total IgA quantification.
Effect of switch to the highest dose of rosuvastatin versus add-on-statin fenofibrate versus add-on-statin nicotinic acid/laropiprant on oxidative stress markers in patients with mixed dyslipidemia.

INTRODUCTION
Oxidative stress plays an important role in atherosclerosis. Both F2-isoprostane (8-iso-PGF2a) and oxidized low-density lipoprotein (ox-LDL) have emerged as biomarkers of oxidative stress and have been proposed as useful biomarkers that could potentially be used as indicators of cardiovascular disease.


METHODS
This is a prespecified analysis of a prospective, randomized, open-label, blinded endpoint (PROBE) study (ClinicalTrials.gov identifier: NCT01010516). Patients (N = 100) with mixed dyslipidemia on a standard statin dose (10-40 mg simvastatin or 10-20 mg atorvastatin or 5-10 mg rosuvastatin) who had not achieved lipid targets were randomized to switch to the highest dose of rosuvastatin (40 mg/day) or to add-on-statin extended release nicotinic acid (ER-NA)/laropiprant (LRPT) (1000/20 mg/day for the first 4 weeks followed by 2000/40 mg/day for the next 8 weeks) or to add-on-statin micronized fenofibrate (200 mg/day) for a total of 3 months. Levels of plasma and urine F2-isoprostane and plasma ox-LDL were assessed at baseline and 3 months later.


RESULTS
Plasma F2-isoprostane levels decreased similarly in all groups. On the other hand, both ox-LDL and urine F2-isoprostane levels decreased similarly in the add-on ER-NA/LRPT and rosuvastatin monotherapy group, while a less pronounced decrease was observed in the add-on fenofibrate group.


CONCLUSIONS
All treatment interventions reduced the concentration of the assessed oxidative stress markers, but the reduction was more pronounced in the add-on ER-NA/LRPT and rosuvastatin monotherapy groups, compared with add-on fenofibrate. Specifically designed studies should address the abovementioned risk factors modulation in terms of cardiovascular risk.
A spline-based algorithm for continuous time-delay estimation using sampled data

Time delay estimation (TDE) lies at the heart of signal processing algorithms in a broad range of application areas, including communications, coherent imaging, speech processing, and acoustics. In medical ultrasound for example, TDE is used in blood flow estimation, tissue motion measurement, tissue elasticity estimation, phase aberration correction, and a number of other algorithms. Because of its central significance, TDE accuracy, precision, and computational cost are of critical importance. Furthermore, because TDE is typically performed on sampled signals - and delay estimates are usually desired over a continuous domain - time delay estimator performance should be considered in conjunction with associated interpolation. In this paper, we present a new time-delay estimator that directly determines continuous time-delay estimates from sampled data. The technique forms a spline-based, piece-wise continuous representation of the reference signal then solves for the minimum of the sum squared error between the reference and the delayed signals to determine their relative time delay. Computer simulation results clearly show that the proposed algorithm significantly outperforms other algorithms in terms of jitter and bias over a broad range of conditions. We also describe a modified version of the algorithm that includes companding with only a minor increase in computational cost
About the Interpretation of Gravitationally Induced Neutrino Oscillation Phases

We present some thoughts on how to interpret the gravitionally induced neutrino oscillation phases presented by us in our 1996 Gravity Research Foundation Essay.
Botulinum toxin treatment of children with cerebral palsy — a short review of different injection techniques

The intramuscular application of botulinum toxin type A (BoNT/A) has emerged to be an established treatment option to reduce muscular hyperactivity due to spasticity in children with cerebral palsy. Accurate injection is a prerequisite for efficient and safe treatment with BoNT/A. So far, treatment procedures have not been standardized. This paper is a short review of different injection techniques, i.e., manual needle placement as well as guidance by electromyography, electrical stimulation, and ultrasound. Advantages and disadvantages of the different injection techniques are discussed with a focus on needle positioning within the targeted muscle, injection close to the neuromuscular junction and diffusion of BoNT/A within the target muscles and through fascia. The additional information gained by each injection technique is weighed in terms of the clinical impact for children with cerebral palsy.
PDLK: Plagiarism detection using linguistic knowledge

Plagiarism is described as the reuse of someone else’s previous ideas, work or even words without sufficient attribution to the source. This paper presents a method to detect external plagiarism using the integration of semantic relations between words and their syntactic composition. The problem with the available methods is that they fail to capture the meaning in comparison between a source document sentence and a suspicious document sentence, when two sentences have same surface text (the words are the same) or they are a paraphrase of each other. Therefore it causes inaccurate or unnecessary matching results. However, this method can improve the performance of plagiarism detection because it is able to avoid selecting the source text sentence whose similarity with suspicious text sentence is high but its meaning is different. It is executed by computing the semantic and syntactic similarity of the sentence-to-sentence. Besides, the proposed method expands the words in sentences to tackle the problem of information limit. It bridges the lexical gaps for semantically similar contexts that are expressed in a different wording. This method is also capable to identify various kinds of plagiarism such as the exact copied text, paraphrasing, transformation of sentences and changing of word structure in the sentences. As a result, the experimental results have displayed that the proposed method is able to improve the performance compared with the participating systems in PAN-PC11. The experimental results also displayed that the proposed method demonstrates better performance as compared to other existing techniques on PAN-PC-10 and PAN-PC-11 datasets. © 2015 Elsevier Ltd. All rights reserved.
Systematic evaluation of a recently introduced 2-microm continuous-wave thulium laser for vaporesection of the prostate.

BACKGROUND AND PURPOSE
A novel 2-microm continuous wave (CW) thulium laser device for interventional treatment of benign prostatic hyperplasia was recently introduced into clinical practice and is postulated to have several advantages over more established laser devices. A systematic ex-vivo evaluation of the thulium laser was undertaken to compare the results to transurethral resection of the prostate (TURP) and the potassium-titanyl-phosphate (KTP) laser as reference standard methods.


MATERIALS AND METHODS
The RevoLix CW thulium laser system was evaluated in the well-established model of the isolated blood-perfused porcine kidney to determine its tissue ablation capacity and hemostatic properties at different power settings. Histologic examination of the ablated tissue followed. The results were compared to the reference standards, TURP and 80-W KTP laser.


RESULTS
At a power setting of 70 W, the CW thulium laser displays a higher tissue ablation rate, reaching 6.56+/-0.69 g after 10 minutes, compared to the 80 W KTP laser (3.99+/-0.48 g; P<0.05). Only 30 seconds were needed to resect tissue with the same surface area using TURP, resulting in 8.28+/-0.38 g of tissue removal. With a bleeding rate of 0.16+/-0.07 g/min, the CW thulium laser offers hemostatic properties equal to those of the KTP laser (0.21+/-0.07 g/min), and a significantly reduced bleeding rate compared to TURP (20.14+/-2.03 g/min; P<0.05). The corresponding depths of the coagulation zones were 264.7+/-41.3 microm for the CW thulium laser, 666.9+/-64.0 microm for the KTP laser (P<0.05), and 287.1+/-27.5 microm for TURP.


CONCLUSION
In this standardized ex-vivo investigation, the 2-microm CW thulium laser offered a higher tissue ablation capacity and similar hemostatic properties as those of the KTP laser, and in comparison to TURP both tissue ablation and the bleeding rate were significantly reduced.
Genetic and Environmental Causes of Variation in Trait Resilience in Young People

The aim of this multi-informant twin study was to determine the relative role of genetic and environmental factors in explaining variation in trait resilience in adolescents. Participants were consenting families (N = 2,638 twins in 1,394 families), from seven national cohorts (age 12-18 years, both sexes) of monozygotic and dizygotic twins reared together. Questionnaire data on the adolescents' Ego-resilience (ER89) was collected from mothers, fathers and twins, and analysed by means of multivariate genetic modelling. Variance in trait resilience was best represented in an ADE common pathways model with sex limitation. Variance in the latent psychometric resilience factor was largely explained by additive genetic factors (77% in boys, 70% in girls), with the remaining variance (23 and 30%) attributable to non-shared environmental factors. Additive genetic sources explained more than 50% of the informant specific variation in mothers and fathers scores. In twins, additive and non-additive genetic factors together explained 40% and non-shared environmental factor the remaining 60% of variation. In the mothers' scores, the additive genetic effect was larger for boys than for girls. The non-additive genetic factor found in the twins' self ratings was larger in boys than in girls. The remaining sex differences in the specific factors were small. Trait resilience is largely genetically determined. Estimates based on several informants rather than single informants approaches are recommended.
Subliminal Persuasion and Its Potential for Driver Behavior Adaptation

Mental overload is a problem drivers are increasingly exposed to in today's complex task of vehicle operation and is one of the causes of traffic accidents or hazards. To keep road safety high but allow for additional information to be forwarded to the driver, we propose to employ subliminal persuasion: a technique where the information is transferred below the level of conscious awareness. Thus, the driver becomes aware of the information, but his/her cognitive load is unaltered. To analyze the potential of this approach, we have designed a case study implementing an “eco-driving” strategy operating in the background. Driving economy is thereby estimated based on vehicles' mileage gathered in real time from numerous sensors in and around the car, and information is conveyed to the driver with very light, not attentively perceivable, vibration patterns originating from tactor elements integrated into the safety belt or the car seat. The main research hypothesis followed in this paper and investigated in real driving studies is that drivers would operate their vehicles more economically on vibrotactile instructions perceived inattentively, as compared with the case without any notifications. Indeed, results indicate an improvement in driving economy for segments driven with subliminal feedback compared with routes driven without assistance but not without qualifications. Statistical significance has been proven for the safety belt interface, whereas it has not been substantiated for the tactile car seat. (However, more research is needed to validate the applicability of subliminal persuasion across a wider range of driving and in-vehicle tasks.).
Performance of Turbo coded wireless link for SISO-OFDM, SIMO-OFDM, MISO-OFDM and MIMO-OFDM system

In this paper, performance of a Turbo coded OFDM wireless link is evaluated in the presence of Rayleigh fading for SISO, SIMO, MISO and MIMO system. Data are encoded using turbo encoder then modulated by QPSK or 16 QAM or 64 QAM and further encoded using STBC, and the encoded data are split into n streams which are modulated by OFDM and simultaneously transmitted using n transmit antennas. It is observed that the turbo coded SISO-OFDM system provides 21 dB coding gain at 10−4, turbo coded SIMO-OFDM system provides 20 and 13 db coding gain for 2 and 4 receive antennas respectively at a BER of 10−6, turbo coded MISO-OFDM system provides 17 and 12 dB coding gain for 2 and 4 transmit antennas respectively at a BER of 10−6 and turbo coded MIMO-OFDM system provides 11 to 13 dB coding gain for different combination of transmit and receive antennas at BER 10−6 compare to uncoded SISO-OFDM, SIMO-OFDM, MISO-OFDM and MIMO-OFDM system.
Evaluation of the ureter and ureterovesicular junction using helical computed tomographic excretory urography in healthy dogs.

Abdominal computed tomography (CT) using a protocol designed for evaluation of the ureters was performed on six normal purpose-bred research dogs. After noncontrast CT, a postcontrast scan was performed 3 min post midpoint of injection of 400 mgI/kg body weight of diatrizoate meglumine/sodium. Ureteral and ureterovesicular junction anatomy were readily assessed with minimal patient preparation. The ureters were similar in size to reported values and the renal pelvis, ureter, and ureterovesicular junction were easily identified on both noncontrast and contrast-enhanced scans. There was a significant relationship between bladder volume and interureterovesicular junction distance but not between bladder volume and ureterovesicular junction to internal urethral orifice distance. A reliable bony landmark for the identification of the internal urethral orifice could not be determined. The results of this preliminary study of normal anatomy should facilitate the clinical use of CT in the evaluation of ureteral disease (e.g., ureteral ectopia).
Strong coupling through optical positioning of a quantum dot in a photonic crystal cavity

in a photonic crystal cavity Susanna M. Thon, Matthew T. Rakher, Hyochul Kim, Jan Gudat, William T. M. Irvine, Pierre M. Petroff, and Dirk Bouwmeester Department of Physics, University of California Santa Barbara, Santa Barbara, California 93106, USA Huygens Laboratory, Leiden University, P.O. Box 9504, 2300 RA Leiden, The Netherlands Department of Materials, University of California Santa Barbara, Santa Barbara, California 93106, USA Department of ECE, University of California Santa Barbara, Santa Barbara, California 93106, USA
The role of school health centers in health care access and client outcomes.

OBJECTIVES
We describe the impact of school health centers in Alameda County, California, on adolescents' access to care and their mental and physical health outcomes.


METHODS
We used a multimethod evaluation of 12 school health centers to track data on clients (n=7410), services, and provider-reported outcomes; client pre-post surveys (n=286); and student focus groups (n=105 participants).


RESULTS
School health centers were the most commonly reported source of medical (30%), family planning (63%), and counseling (31%) services for clients. Mental health providers reported significant improvements (P<.05) from baseline to follow-up in clients' presenting concerns and resiliency factors. Medical providers and clients also reported general improvements in reproductive health, particularly in the use of birth control other than condoms. Student focus group participants noted that school health centers helped improve access to services students might not seek out otherwise, particularly counseling and family planning services. Furthermore, students noted that they liked school health centers because of their confidentiality, free services, convenience, and youth-friendly staff.


CONCLUSIONS
School health centers increase access to care and improve mental health, resiliency, and contraceptive use.
Engineering animations in user interfaces

Graphical User Interfaces used to be static, graphically representing one software state after the other. However, animated transitions between these static states are an integral part in modern user interfaces and processes for both their design and implementation remain a challenge for designers and developers.
 This paper proposes a Petri net model-based approach to support the design, implementation and validation of animated user interfaces by providing a complete and unambiguous description of the entire user interface including animations. A process for designing interactive systems focusing on animations is presented, along with a framework for the definition and implementation of animation in user interfaces. The framework proposes a two levels approach for defining a high-level view of an animation (focusing on animated objects, their properties to be animated and on the composition of animations) and a low-level one dealing with detailed aspects of animations such as timing and optimization. A case study (in the domain of interactive Television) elaborating the application of the presented process and framework exemplifies the contribution.
Toward a framework for data quality in cloud-based health information system

This Cloud computing is a promising platform for health information systems in order to reduce costs and improve accessibility. Cloud computing represents a shift away from computing being purchased as a product to be a service delivered over the Internet to customers. Cloud computing paradigm is becoming one of the popular IT infrastructures for facilitating Electronic Health Record (EHR) integration and sharing. EHR is defined as a repository of patient data in digital form. This record is stored and exchanged securely and accessible by different levels of authorized users. Its key purpose is to support the continuity of care, and allow the exchange and integration of medical information for a patient. However, this would not be achieved without ensuring the quality of data populated in the healthcare clouds as the data quality can have a great impact on the overall effectiveness of any system. The assurance of the quality of data used in healthcare systems is a pressing need to help the continuity and quality of care. Identification of data quality dimensions in healthcare clouds is a challenging issue as data quality of cloud-based health information systems arise some issues such as the appropriateness of use, and provenance. Some research proposed frameworks of the data quality dimensions without taking into consideration the nature of cloud-based healthcare systems. In this paper, we proposed an initial framework that fits the data quality attributes. This framework reflects the main elements of the cloud-based healthcare systems and the functionality of EHR.