LLukas22/scidocs huggingface dataset:
Hemispherectomy in pediatric patients with epilepsy: a study of 45 cases with special emphasis on epileptic syndromes

In this study we report the clinical outcomes of hemispherectomy for epilepsy in pediatric patients with special emphasis on the epileptic syndromes and their etiologies. We retrospectively studied 45 patients with medically refractory epilepsy with hemispheric lesions who underwent hemispherectomy at the “Hospital de Pediatría Prof. Dr. Juan P. Garrahan”, Buenos Aires, Argentina between February 1990 and February 2010. Patients had been assessed using a standard protocol involving clinical, neuroradiological, neurophysiological, and neuropsychological teams. Twenty-seven males and 18 females with a mean age of 8.5 years (range, 2 months to 18 years) who underwent epilepsy surgery for refractory epilepsy were assessed. The mean time of follow-up was 9.5 years (range, 1 to 16 years). The following epileptic syndromes were recognized: West syndrome in 15 patients (33.5%), Rasmussen syndrome in 13 (29%), focal symptomatic epilepsy in 8 (17.5%), startle epilepsy in 6 (13.5%), Lennox–Gastaut syndrome in 2 (5%), and continuous spikes and waves during slow sleep in 1 (2%). The surgical specimens revealed malformations of cortical development in 18 patients (40%), Rasmussen encephalitis in 13 (29%), porencephalic lesions in 10 (22%), gliosis in 2 (4.4%), tumor in 1 (2.2%), and Sturge–Weber syndrome in 1 (2.2%). The outcome of hemispherectomy in pediatric patients is good for those with refractory epilepsies, such as West syndrome, Lennox–Gastaut syndrome, epileptic encephalopathy with continuous spikes and waves during slow sleep, and startle epilepsy arising from a hemispheric lesion associated with hemiplegia.
Survival benefit in a randomized clinical trial of faecal occult blood screening for colorectal cancer.

BACKGROUND
Early detection of colorectal cancer could reduce cancer-specific mortality. The aim of this trial was to evaluate the effect of faecal occult blood test (FOBT) screening on colorectal cancer mortality in a Swedish population.


METHODS
All 68,308 citizens in Göteborg born between 1918 and 1931 were randomized to a screening or a control group at the age of 60-64 years. All were screened two to three times with rehydrated Hemoccult-II. Compliance was 70.0 per cent (23,916 individuals). Those with a positive test result were offered sigmoidoscopy and a double-contrast enema. The primary endpoint was death from colorectal cancer.


RESULTS
After a mean of 9 years from the last screening, there was a significant reduction in colorectal cancer mortality in the screening group compared with the control group. The overall risk ratio of death from colorectal cancer was 0.84 (95 per cent confidence interval 0.71 to 0.99). The groups did not differ in incidence of colorectal cancer or in overall mortality.


CONCLUSION
FOBT screening significantly reduces colorectal cancer mortality.
created by a radially magnetized tile permanent magnet

This paper presents the exact analytical formulation of the three components of the magnetic field created by a radially magnetized tile permanent magnet. These expressions take both the magnetic pole surface densities and the magnetic pole volume density into account. So, this means that the tile magnet curvature is completely taken into account. Moreover, the magnetic field can be calculated exactly in any point of the space, should it be outside the tile magnet or inside it. Consequently, we have obtained an accurate 3D magnetic field as no simplifying assumptions have been used for calculating these three magnetic components. Thus, this result is really interesting. Furthermore, the azimuthal component of the field can be determined without any special functions. In consequence, its computational cost is very low which is useful for optimization purposes. Besides, all the other expressions obtained are based on elliptic functions or special functions whose numerical calculation is fast and robust and this allows us to realize parametric studies easily. Eventually, we show the interest of this formulation by applying it to one example: the calculation and the optimization of alternate magnetization magnet devices. Such devices are commonly used in various application fields: sensors, motors, couplings, etc. The point is that the total field is calculated by using the superposition theorem and summing the contribution to the field of each tile magnet in any point of the space. This approach is a good alternative to a finite element method because the calculation of the magnetic field is done without any simplifying assumption.
The Hermitian two matrix model with an even quartic potential

We consider the two matrix model with an even quartic potential W (y) = y/4 + αy/2 and an even polynomial potential V (x). The main result of the paper is the formulation of a vector equilibrium problem for the limiting mean density for the eigenvalues of one of the matrices M1. The vector equilibrium problem is defined for three measures, with external fields on the first and third measures and an upper constraint on the second measure. The proof is based on a steepest descent analysis of a 4 × 4 matrix valued Riemann-Hilbert problem that characterizes the correlation kernel for the eigenvalues of M1. Our results generalize earlier results for the case α = 0, where the external field on the third measure was not present.
Job characteristics and job satisfaction among physicians involved with research in the veterans health administration.

PURPOSE
Research conducted by physicians generates knowledge and has led to important advances and changes in the health care system. Physician retention is a concern facing many health care systems, and job satisfaction and attitudes play a role in retention. This study examined whether physicians who are involved with research have greater job satisfaction and more positive job characteristics perceptions.


METHOD
Cross-sectional analysis examined this research question using a sample of 7,734 physicians across 135 medical centers in the Department of Veterans Affairs (VA) in 2008. Using existing survey results, ratings on job characteristics (job autonomy, skill development opportunities, work and family balance, and performance feedback) and job satisfaction were regressed on research involvement in a multilevel hierarchical generalized linear model. The model controlled for physician-level characteristics and organization-level characteristics related to research activities.


RESULTS
Analyses revealed that physicians who spent part of their time involved with research activities were more likely to report favorable job characteristics ratings. Physicians involved with research were also more likely to be satisfied with their job. Physicians who worked in medical centers with greater levels of research funding were more likely to report favorable ratings for job characteristics and job satisfaction.


CONCLUSIONS
Involvement with research was associated with more favorable job characteristics and job satisfaction perceptions among physicians in VA. Although there is a time and opportunity cost involved with research, medical centers that provide physicians with the opportunity to conduct research may have a more satisfied workforce.
RacerX: effective, static detection of race conditions and deadlocks

This paper describes RacerX, a static tool that uses flow-sensitive, interprocedural analysis to detect both race conditions and deadlocks. It is explicitly designed to find errors in large, complex multithreaded systems. It aggressively infers checking information such as which locks protect which operations, which code contexts are multithreaded, and which shared accesses are dangerous. It tracks a set of code features which it uses to sort errors both from most to least severe. It uses novel techniques to counter the impact of analysis mistakes. The tool is fast, requiring between 2-14 minutes to analyze a 1.8 million line system. We have applied it to Linux, FreeBSD, and a large commercial code base, finding serious errors in all of them. RacerX is a static tool that uses flow-sensitive, interprocedural analysis to detect both race conditions and deadlocks. It uses novel strategies to infer checking information such as which locks protect which operations, which code contexts are multithreaded, and which shared accesses are dangerous. We applied it to FreeBSD, Linux and a large commercial code base and found serious errors in all of them.
Homeless young people and technology: ordinary interactions, extraordinary circumstances

In this forum we will celebrate research that helps to successfully bring the benefits of computing technologies to children, older adults, people with disabilities, and other populations that are often ignored in the design of mass-marketed products. Juan Pablo Hourcade, Editor
Training affects knee kinematics and kinetics in cutting maneuvers in sport.

PURPOSE
The current study examined how different training affects the kinematics and applied moments at the knee during sporting maneuvers and the potential to reduce loading of the anterior cruciate ligament (ACL). The training programs were 1) machine weights, 2) free weights, 3) balance training, and 4) machine weights + balance training.


METHODS
Fifty healthy male subjects were allocated either to a control group or to one of four 12-wk training programs. Subjects were tested before and after training, performing running and cutting maneuvers from which knee angle and applied knee moments were assessed. Data analyzed were peak applied flexion/extension, varus/valgus, and internal/external rotation moments, as well as knee flexion angles during specific phases of stance during the maneuvers.


RESULTS
The balance training group decreased their peak valgus and peak internal rotation moments during weight acceptance in all maneuvers. This group also lowered their flexion moments during the sidestep to 60 degrees . Free weights training induced increases in the internal rotation moment and decreases in knee flexion angle in the peak push-off phase of stance. Machine weights training elicited increases in the flexion moment and reduced peak valgus moments in weight acceptance. Machine weights + balance training resulted in no changes to the variables assessed.


CONCLUSIONS
Balance training produced reductions in peak valgus and internal rotation moments, which could lower ACL injury risk during sporting maneuvers. Strength training tended to increase the applied knee loading known to place strain on the ACL, with the free weights group also decreasing the amount of knee flexion. It is recommended that balance training be implemented because it may reduce the risk of ACL injury.
Beyond citation analysis: a model for assessment of research impact.

QUESTION
Is there a means of assessing research impact beyond citation analysis?


SETTING
The case study took place at the Washington University School of Medicine Becker Medical Library.


METHOD
This case study analyzed the research study process to identify indicators beyond citation count that demonstrate research impact.


MAIN RESULTS
The authors discovered a number of indicators that can be documented for assessment of research impact, as well as resources to locate evidence of impact. As a result of the project, the authors developed a model for assessment of research impact, the Becker Medical Library Model for Assessment of Research.


CONCLUSION
Assessment of research impact using traditional citation analysis alone is not a sufficient tool for assessing the impact of research findings, and it is not predictive of subsequent clinical applications resulting in meaningful health outcomes. The Becker Model can be used by both researchers and librarians to document research impact to supplement citation analysis.
Do Patients Want to Talk to Their Physicians about Organ Donation? Attitudes and Knowledge about Organ Donation: A Study of Orange County, California Residents

This study surveyed Orange County, California residents to determine their attitudes and knowledge about organ donation and in particular to determine what factors influence the decision to donate one's organs upon death. Respondents were recruited from the Orange County Superior Court jury pool (N = 378). Each completed a 44 item questionnaire. Findings from the analysis of Questionnaire Data reveal that nearly three-quarters of respondents had considered donating their organs, yet less than one-third had made arrangements to donate. Having an accurate knowledge about organ donation and being willing to accept a donated organ were particularly robust factors associated with the likelihood to donate. Having spoken with a physician was also a positive factor, yet just 5% of the sample had done so, and two-thirds of respondents did not want to discuss organ donation with their physician. The study's findings suggest that enhanced recruitment may be achieved by focusing on education (especially increased emphasis on the family's role) and by targeting both parents and their children. Finally, although physicians are encouraged to discuss organ donation with patients, more information is needed to explain why patients may not want to talk about this topic with their doctors.
Prevention and management of vision loss relating to facial filler injections.

INTRODUCTION
With the increased use of filler and fat injections for aesthetic purposes, there has been a corresponding increase in the incidence of complications. Vision loss as an uncommon but devastating vascular side effect of filler injections was the focus of this paper.


METHODS
A review committee, consisting of plastic surgeons, aesthetic medical practitioners, ophthalmologists and dermatologists from Singapore, was convened by the Society of Aesthetic Medicine (Singapore) to review and recommend methods for the prevention and management of vision loss secondary to filler injections.


RESULTS
The committee agreed that prevention through proper understanding of facial anatomy and good injection techniques was of foremost importance. The committee acknowledged that there is currently no standard management for these cases. Based on existing knowledge, injectors may follow a proposed course of action, which can be divided into immediate, definitive and supportive. The goals were to reduce intraocular pressure, dislodge the embolus to a more peripheral location, remove or reverse central ischaemia, preserve residual retinal function, and prevent the deterioration of vision. Dissolving a hyaluronic acid embolus remains a controversial option. It is proposed that injectors must be trained to recognise symptoms, institute immediate actions and refer patients without delay to dedicated specialists for definitive and supportive management.


CONCLUSIONS
Steps to prevent and manage vision loss based on current evidence and best clinical practices are outlined in this paper. Empirical referral to any emergency department or untrained doctors may lead to inordinate delays and poor outcomes for the affected eye.
A pilot randomized controlled trial of the feasibility of a self-directed coping skills intervention for couples facing prostate cancer: Rationale and design

BACKGROUND
Although it is known both patients' and partners' reactions to a prostate cancer diagnosis include fear, uncertainty, anxiety and depression with patients' partners' reactions mutually determining how they cope with and adjust to the illness, few psychosocial interventions target couples. Those that are available tend to be led by highly trained professionals, limiting their accessibility and long-term sustainability. In addition, it is recognised that patients who might benefit from conventional face-to-face psychosocial interventions do not access these, either by preference or because of geographical or mobility barriers. Self-directed interventions can overcome some of these limitations and have been shown to contribute to patient well-being. This study will examine the feasibility of a self-directed, coping skills intervention for couples affected by cancer, called Coping-Together, and begin to explore its potential impact on couples' illness adjustment. The pilot version of Coping-Together includes a series of four booklets, a DVD, and a relaxation audio CD.


METHODS/DESIGN
In this double-blind, two-group, parallel, randomized controlled trial, 70 couples will be recruited within 4 months of a prostate cancer diagnosis through urology private practices and randomized to: 1) Coping-Together or 2) a minimal ethical care condition. Minimal ethical care condition couples will be mailed information booklets available at the Cancer Council New South Wales and a brochure for the Cancer Council Helpline. The primary outcome (anxiety) and additional secondary outcomes (distress, depression, dyadic adjustment, quality of life, illness or caregiving appraisal, self-efficacy, and dyadic and individual coping) will be assessed at baseline (before receiving study material) and 2 months post-baseline. Intention-to-treat and per protocol analysis will be conducted.


DISCUSSION
As partners' distress rates exceed not only population norms, but also those reported by patients themselves, it is imperative that coping skills interventions target the couple as a unit and enhance both partners' ability to overcome cancer challenges. This pilot study will examine the feasibility and potential efficacy of Coping-Together in optimising couples' illness adjustment. This is one of the first feasibility studies to test this innovative coping intervention, which in turn will contribute to the larger literature advocating for psychosocial care of couples affected by prostate cancer.


TRIAL REGISTRATION
Australian New Zealand Clinical Trials Registry ACTRN12611000438954.
Integrated management of type 2 diabetes mellitus and depression treatment to improve medication adherence: a randomized controlled trial.

PURPOSE
Depression commonly accompanies diabetes, resulting in reduced adherence to medications and increased risk for morbidity and mortality. The objective of this study was to examine whether a simple, brief integrated approach to depression and type 2 diabetes mellitus (type 2 diabetes) treatment improved adherence to oral hypoglycemic agents and antidepressant medications, glycemic control, and depression among primary care patients.


METHODS
We undertook a randomized controlled trial conducted from April 2010 through April 2011 of 180 patients prescribed pharmacotherapy for type 2 diabetes and depression in primary care. Patients were randomly assigned to an integrated care intervention or usual care. Integrated care managers collaborated with physicians to offer education and guideline-based treatment recommendations and to monitor adherence and clinical status. Adherence was assessed using the Medication Event Monitoring System (MEMS). We used glycated hemoglobin (HbA(1c)) assays to measure glycemic control and the 9-item Patient Health Questionnaire (PHQ-9) to assess depression.


RESULTS
Intervention and usual care groups did not differ statistically on baseline measures. Patients who received the intervention were more likely to achieve HbA(1c) levels of less than 7% (intervention 60.9% vs. usual care 35.7%; P < .001) and remission of depression (PHQ-9 score of less than 5: intervention 58.7% vs. usual care 30.7%; P < .001) in comparison with patients in the usual care group at 12 weeks.


CONCLUSIONS
A randomized controlled trial of a simple, brief intervention integrating treatment of type 2 diabetes and depression was successful in improving outcomes in primary care. An integrated approach to depression and type 2 diabetes treatment may facilitate its deployment in real-world practices with competing demands for limited resources.
The influence of strut thickness and cell design on immediate apposition of drug-eluting stents assessed by optical coherence tomography.

BACKGROUND
Stent strut malapposition correlates with poor intimal coverage and this may increase the risk of late stent thrombosis. At present, there is limited data on whether stent strut thickness and stent design impact on acute apposition. We aimed to investigate the influence of stent strut thickness and design on acute stent strut apposition (SSA) immediately following drug-eluting stent (DES) implantation using optical coherence tomography (OCT), a technique with higher resolution and fewer artefacts than intravascular ultrasound.


METHODS
Thirty-six DES in 23 patients (25 lesions) were studied by OCT. SSA was defined as embedded when a strut was buried in the intima for more than half its thickness, protruding when apposed to the intima but not embedded and malapposed when there was no intimal contact.


RESULTS
Cypher Select stents were implanted in 52%, Taxus Liberte in 32%, Costar in 12% and Endeavour in 4%. A total of 6402 struts were evaluated. Despite stent optimisation using balloons with a final balloon/artery ratio of 1.26+/-0.19 at a maximum inflation pressure of 17.5+/-3.0 atm, only 57.1+/-20.7% of struts were embedded, whereas 33.8+/-18.4% were protruding and 9.1+/-7.4% were malapposed. Stent type was a strong predictor of malapposition on logistic multilevel analysis (OR 3.95, 95%CI: 1.27-12.23, p=0.017). At 12 months follow-up, there were no adverse clinical events.


CONCLUSION
Despite angiographic optimisation with high pressures and adequately sized balloons, malapposed stent struts are frequently found in complex coronary lesions and more often following the implantation of Cypher Select stents which have a thicker stent strut and closed cell design. With no adverse clinical events at 12 months follow-up, this likely represents a benign phenomenon at least as long as combined anti-platelet therapy is maintained.
VOICE RECOGNITION USING NEURAL NETWORKS

One solution to the crime and illegal immigration problem facing South Africa is the use of biometrics techniques and technology. Biometrics a re methods for recognizing a user based on unique physiological and/or behavioural characteristics of the user. This paper presents the results of a n ongoing work in using neural networks for voice recognition. KeywordVoice recognition, Neural Networks
Established dietary estimates of net acid production do not predict measured net acid excretion in patients with Type 2 diabetes on Paleolithic–Hunter–Gatherer-type diets

Background/objectives:Formulas developed to estimate diet-dependent net acid excretion (NAE) generally agree with measured values for typical Western diets. Whether they can also appropriately predict NAE for ‘Paleolithic-type’ (Paleo) diets—which contain very high amounts of fruits and vegetables (F&V) and concurrent high amounts of protein is unknown. Here, we compare measured NAEs with established NAE estimates in subjects with Type 2 diabetes (T2D).Subjects/methods:Thirteen subjects with well-controlled T2D were randomized to either a Paleo or American Diabetes Association (ADA) diet for 14 days. Twenty-four hour urine collections were performed at baseline and end of the diet period, and analyzed for titratable acid, bicarbonate and ammonium to calculate measured NAE. Three formulas for estimating NAE from dietary intake were used; two (NAE_diet R or L) that include dietary mineral intake and sulfate- and organic acid (OA) production, and one that is empirically derived (NAE_diet F) only considering potassium and protein intake.Results:Measured NAE on the Paleo diet was significantly lower than on the ADA-diet (+31±22 vs 112±52 mEq/day, P=0.002). Although all formula estimates showed similar and reasonable correlations (r=0.52–0.76) with measured NAE, each one underestimated measured values. The formula with the best correlation did not contain an estimate of dietary OA production.Conclusions:Paleo-diets are lower in NAE than typical Western diets. However, commonly used formulas clearly underestimate NAE, especially for diets with very high F&V (as the Paleo diet), and in subjects with T2D. This may be due to an inappropriate estimation of proton loads stemming from OAs, underlining the necessity for improved measures of OA-related proton sources.