LLukas22/scidocs huggingface dataset:
Early and short-term acenocumarine or dalteparin for the prevention of central vein catheter-related thrombosis in cancer patients: a randomized controlled study based on serial venographies.

BACKGROUND
We evaluated efficacy and safety of early and short-term prophylaxis with acenocumarine or dalteparin in the prevention of non-occlusive or occlusive central vein catheter-related thrombosis (CVCrT).


PATIENTS AND METHODS
Consecutive cancer patients scheduled for chemotherapy randomly received: acenocumarine 1 mg/day for 3 days before and 8 days after central vein catheter (CVC) insertion; dalteparin 5000 IU 2 h before and daily for 8 days after CVC insertion; no anticoagulant treatment (NT). All patients underwent venography on days 8 and 30, some of them on days 90, 150 and 210 after CVC.


RESULTS
A total of 450 patients were randomized, 348 underwent at least two venography. Both acenocumarine and dalteparin reduced venography-detected CVCrT rate [21.9% acenocumarine versus 52.6% NT, odds ratio (OR) 0.3, P < 0.01; 40% dalteparin versus 52.6% NT, OR 0.6, P = 0.05]. Acenocumarine was more effective than dalteparin (OR 0.4, P = 0.01). The rate of occlusive CVCrT was not different in the three groups (0.9% acenocumarine, 3.3% dalteparin, 1.8% NT; P = 0.40). Most CVCrTs (95.6%) were observed on day 8 after CVC insertion and were non-occlusive.


CONCLUSIONS
In this study of early and short-term prophylaxis, acenocumarine was more effective than dalteparin on non-occlusive and asymptomatic CVCrT events. The first days following CVC insertion represent the highest risk for CVCrT.
Highly-Scalable Searchable Symmetric Encryption with Support for Boolean Queries

This work presents the design, analysis and implementation of the first searchable symmetric encryption (SSE) protocol that supports conjunctive search and general Boolean queries on outsourced symmetrically-encrypted data and that scales to very large databases and arbitrarilystructured data including free text search. To date, work in this area has focused mainly on single-keyword search. For the case of conjunctive search, prior dedivated SSE constructions (not using generic technique such as FHE or ORAM) required work linear in the total number of documents in the database and provided good privacy only for structured attribute-value data, rendering these solutions too slow and inflexible for large practical databases. In contrast, our solution provides a realistic and practical trade-off between performance and privacy by efficiently supporting very large databases at the cost of moderate and welldefined leakage to the outsourced server (leakage is in the form of data access patterns, never as direct exposure of plaintext data or searched values). Our design follows a careful process of trading security for efficiency which are both quantified via rigorous analysis. We present a detailed formal cryptographic analysis of the privacy and security of our protocols and establish precise upper bounds on the allowed leakage. To demonstrate the real-world practicality of our approach, we provide performance results of a prototype applied to several large representative data sets, including encrypted search over the whole English Wikipedia (and beyond). This is the full version of the paper with same title appearing at Crypto’2013. Rutgers U. Email: david.cash@cs.rutgers.edu. U. California Irvine. Email: stasio@ics.uci.edu. IBM Research. Email: csjutla@us.ibm.com IBM Research. Email: hugo@ee.technion.ac.il IBM Research. Email: marcelrosu@gmail.com IBM Research. Email: steiner@acm.org
Inflammatory bowel disease is associated with an increased risk of hospitalization for heart failure: a Danish Nationwide Cohort study.

BACKGROUND
Inflammatory bowel disease (IBD) has been linked to adverse cardiovascular events, but a relation to heart failure (HF) is uncertain. We investigated the IBD-associated risk of HF in a nationwide setting.


METHODS AND RESULTS
A total of 5 436 647 Danish citizens, with no history of IBD or HF, were included on January 1, 1997, and followed up until first hospitalization for HF, death, or December 31, 2011. Of these subjects, 23 681 developed IBD for which disease activity was determined continuously throughout the study. The risk of hospitalization for HF was estimated with a Poisson regression model adjusting for comorbidity and cardiovascular pharmacotherapy as time-dependent covariates. During a mean follow-up of 11.8 years in the reference population and 6.4 years in the IBD group, hospitalization for HF occurred in 553 subjects with IBD and 171 405 in the reference population. Patients with IBD had a 37% increased risk of hospitalization for HF (incidence rate ratio, 1.37; 95% confidence interval, 1.26-1.49) compared with the reference population. IBD activity-specific analyses showed markedly increased risk of HF hospitalization during flares (incidence rate ratio, 2.54; 95% confidence interval, 2.13-3.04) and persistent activity (incidence rate ratio, 2.73; 95% confidence interval, 2.25-3.33) but not in IBD remission (incidence rate ratio, 1.04; 95% confidence interval, 0.94-1.16).


CONCLUSIONS
In a nationwide cohort, IBD was associated with an increased risk of hospitalization for HF, and this risk was strongly correlated to periods of active disease. The mechanisms underlying this finding warrant further studies.
Predictors of early death risk in older patients treated with first-line chemotherapy for cancer.

PURPOSE
Objective factors for making choices about the treatment of elderly patients with cancer are lacking. This investigation aimed to help physicians select appropriate treatments through the identification of factors that predict early death (< 6 months) after initiation of chemotherapy treatment.


PATIENTS AND METHODS
Previously untreated patients greater than 70 years of age who were scheduled for first-line chemotherapy for various types of cancer were included. Baseline abbreviated comprehensive geriatric assessment (aCGA), including the Mini-Mental State Exam, Timed Get Up and Go (GUG), Activities of Daily Living (ADL), Instrumental Activities in Daily Living (IADL), Mini Nutritional Assessment (MNA), Geriatric Depression Scale (GDS15), and comorbidities index (Cumulative Index Rating Scale-Geriatric), was carried out. Prognostic factors of early death were sought from aCGA results and traditional oncology measures.


RESULTS
A total of 348 patients were included across 12 centers in Southwest France (median age, 77.45 years; ratio of men to women, 1.47; advanced disease, 65%). Abnormal aCGA scores were observed for 18.1% of patients on the ADL, 73.0% of patients on the IADL, 24.1% of patients on the GUG, 19.0% of patients on the MMS, 44.0% of patients on the GDS15, and 64.9% of patients on the MNA. Advanced disease (odds ratio [OR], 3.9; 95% CI, [1.58 to 9.73]), a low MNA score (OR 2.77; 95% CI, [1.24 to 6.18]), male sex (OR, 2.40; 95% CI, [1.2 to 4.82]), and long GUG (OR, 2.55; 95% CI, [1.32 to 4.94] were associated with higher risk of early death.


CONCLUSION
In patients greater than 70 years of age with cancer, advanced disease, a low MNA score, and poor mobility predicted early death. We recommend that the MNA and GUG, performed by a trained nurse, be maintained as part of routine pretreatment workup in these patients to identify at-risk patients and to inform the decision-making process for chemotherapy.
AutoTutor Detects and Responds to Learners Affective and Cognitive States

This paper provides a synthesis of our research towards the development of an affect-sensitive Intelligent Tutoring System called AutoTutor. The affect-sensitive AutoTutor detects the emotions (boredom, flow/engagement, confusion, frustration) of a learner by monitoring conversational cues, gross body language, and facial features. It is also mindful of the learners’ affective and cognitive states in selecting its pedagogical and motivational dialogue moves. Finally, the AutoTutor embodied pedagogical agent synthesizes affective responses through animated facial expressions and modulated speech. The paper provides an overview of our theoretical framework, methodology, implementation details, and results.
Characteristics of different power systems neutral grounding techniques: facts and fiction

Power Systems Grounding is probably the most misunderstood element of any Power Systems design. Therefore, this paper will review the characteristics of different Power Systems Grounding techniques as currently applied -and misapplied within industry today. In many cases, misunderstood concepts and perceptions of the purpose and type of Power Systems Grounding to be selected dates back to the 1940's and earlier. Since that time much research, coupled with experience, has taken place that is now available to industry. This paper will review the many different system grounding practices and present information on different grounding methods. Safety, National Electric Code requirements, and operational considerations, such as continuity of service, will be investigated. Finally, examples of proper applications within various industries will be given.
Midterm II Answer Key ECON 504 - Microeconomics II

Solution The unique pure strategy subgame perfect equilibrium is (Rr, r). 2. (30pts.) An entrepreneur has a project that she presents to a capitalist. She has her own money that she could invest in the project and is looking for additional funding from the capitalist. The project is either good (denoted g) (with probability p) or it is bad (denoted b) (with probability 1− p) and only the entrepreneur knows the quality of the project. The entrepreneur (E) decides whether to invest her own money (I) or not (N), the capitalist (C) observes whether the entrepreneur has invested or not and then decides whether to invest his money (i) or not (n). Figure 1 represents the game and gives the payoffs, where the first number is the entrepreneur’s payoff and the second number is the capitalist’s. (a) (20pts.) Find the set of pure strategy perfect Bayesian equilibria of this game.
Learning executable semantic parsers for natural language understanding

Semantic parsing is a rich fusion of the logical and the statistical worlds.
Feature Selection and Combination Criteria for Improving Accuracy in Protein Structure Prediction

The classification of protein structures is essential for their function determination in bioinformatics. At present, a reasonably high rate of prediction accuracy has been achieved in classifying proteins into four classes in the SCOP database according to their primary amino acid sequences. However, for further classification into fine-grained folding categories, especially when the number of possible folding patterns as those defined in the SCOP database is large, it is still quite a challenge. In our previous work, we have proposed a two-level classification strategy called hierarchical learning architecture (HLA) using neural networks and two indirect coding features to differentiate proteins according to their classes and folding patterns, which achieved an accuracy rate of 65.5%. In this paper, we use a combinatorial fusion technique to facilitate feature selection and combination for improving predictive accuracy in protein structure classification. When applying various criteria in combinatorial fusion to the protein fold prediction approach using neural networks with HLA and the radial basis function network (RBFN), the resulting classification has an overall prediction accuracy rate of 87% for four classes and 69.6% for 27 folding categories. These rates are significantly higher than the accuracy rate of 56.5% previously obtained by Ding and Dubchak. Our results demonstrate that data fusion is a viable method for feature selection and combination in the prediction and classification of protein structure.
RETRACTED ARTICLE: Acamprosate and its efficacy in treating alcohol dependent adolescents

Background: About 50 % of adult alcoholic patients relapse within 3 months of treatment. Previous studies have suggested that acamprosate may help to prevent such relapse. The aim of our study was to assess the efficacy and safety of long-term acamprosate treatment in alcohol dependence of adolescents. Methods: In this, double-blind, placebo-controlled study, we recruited 26 patients, aged 16–19 years, with chronic or episodic alcohol dependence. Patients were randomly allocated treatment with acamprosate (1332 mg daily) or placebo for 90 days. Patients were assessed on the day treatment started and on days 30, and 90 by interview, self report, questionnaire, and laboratory screening. Findings: 13 acamprosate-treated and 13 placebo-treated patients completed the treatment phase: of those withdrawn, 11 (1 vs 6) relapsed, 5 (3 vs 2) refused to continue treatment, 3 (1 vs 2) had concurrent illness, and 2 (1 vs 1) had adverse side-effects. At the end of treatment, 7 acamprosate treated and 2 placebo-treated patients had been continuously abstinent (p = 0.0076). Mean cumulative abstinence duration was significantly greater in the acamprosate group than in the placebo group (79.8 [SD 37.5] vs 32.8 [19.0] days; p = 0.012). Interpretation: Acamprosate is an effective and well-tolerated pharmacological adjunct to psychosocial treatment programmes.
Mutations in HIV-1 reverse transcriptase potentially associated with hypersusceptibility to nonnucleoside reverse-transcriptase inhibitors: effect on response to efavirenz-based therapy in an urban observational cohort.

BACKGROUND
Hypersusceptibility to nonnucleoside reverse-transcriptase inhibitors (NNRTIs) was described in association with reverse-transcriptase (RT) mutations conferring resistance to nucleoside reverse-transcriptase inhibitors (NRTIs). We evaluated the effect of RT mutations associated with hypersusceptibility to NNRTIs on the response to efavirenz-based therapy.


METHODS
We analyzed an observational database of patients for whom highly active antiretroviral therapy failed and who received genotypic resistance testing-guided therapy, either efavirenz or protease inhibitor (PI) based. Study end points were achievement of virus load <80 copies/mL, achievement of virus load <80 copies/mL without rebound to >500 copies/mL, and changes in CD4 cell counts.


RESULTS
The baseline RT mutations M41L, M184V, L210W, and T215Y and the M41L/T215Y and M41L/T215Y/M184V combinations were associated with virological suppression for efavirenz-treated patients, whereas, for PI-treated patients, only the M184V mutation was associated with virological suppression, and the L210W mutation showed a negative correlation; no correlation was found between any mutation and virological response without rebound.


CONCLUSIONS
The M41L, M184V, L210W, and T215Y mutations were associated with a better, although transient, virological outcome in patients treated with efavirenz-based regimens.
Effect of intracoronary streptokinase administered immediately after primary percutaneous coronary intervention on long-term left ventricular infarct size, volumes, and function.

OBJECTIVES
The purpose of this study was to investigate the reflections of the improvement in microvascular perfusion provided by adjuvant intracoronary streptokinase (ICSK) on late-phase infarct size and left ventricular volumes and functions.


BACKGROUND
It has been shown that ICSK given immediately after primary percutaneous coronary intervention (PCI) improves myocardial perfusion in the early days of ST-segment elevation acute myocardial infarction.


METHODS
Ninety-five patients undergoing primary PCI were randomized to ICSK 250 kU (n = 51) or no additional therapy (n = 44). Two days later, coronary hemodynamic indexes were measured to evaluate tissue-level perfusion. After 6 months, angiography, echocardiography, and technetium-99m single-photon emission computed tomography (SPECT) were performed.


RESULTS
At 2 days, all indexes of microvascular function were significantly better in the ICSK group than in the control group, including coronary flow reserve (2.5 vs. 1.7, p < 0.001) and index of microvascular resistance (20.2 vs. 34.2, p < 0.001). At 6 months, infarct size (22.7% vs. 32.9%; p = 0.003) and left ventricular end-systolic (41.1 ml vs. 60.9 ml; p = 0.009) and end-diastolic volumes (95.5 ml vs. 118.3 ml; p = 0.006) were significantly smaller, and the ejection fraction was significantly higher (57.2% vs. 51.8%; p = 0.018) in the ICSK group compared with the control group.


CONCLUSIONS
In this study, it has been demonstrated that low-dose ICSK given immediately after primary PCI significantly limits long-term infarct size and preserves left ventricular volumes and functions. (Effect of Complementary Intracoronary Streptokinase Administration Immediately After Primary Percutaneous Coronary Intervention on Microvascular Perfusion and Late Term Infarct Size in Patients With Acute Myocardial Infarction; NCT00302419).
Dilemmas in the diagnosis of acute community-acquired bacterial meningitis

Rapid diagnosis and treatment of acute community-acquired bacterial meningitis reduces mortality and neurological sequelae, but can be delayed by atypical presentation, assessment of lumbar puncture safety, and poor sensitivity of standard diagnostic microbiology. Thus, diagnostic dilemmas are common in patients with suspected acute community-acquired bacterial meningitis. History and physical examination alone are sometimes not sufficient to confirm or exclude the diagnosis. Lumbar puncture is an essential investigation, but can be delayed by brain imaging. Results of cerebrospinal fluid (CSF) examination should be interpreted carefully, because CSF abnormalities vary according to the cause, patient's age and immune status, and previous treatment. Diagnostic prediction models that use a combination of clinical findings, with or without test results, can help to distinguish acute bacterial meningitis from other causes, but these models are not infallible. We review the dilemmas in the diagnosis of acute community-acquired bacterial meningitis, and focus on the roles of clinical assessment and CSF examination.
Low-harmonic, three-phase rectifier that applies current injection and a passive resistance emulator

A new three-phase diode bridge rectifier that provides low harmonic distortion of the input currents applying current injection technique is proposed in this paper. The rectifier applies a novel passive resistance emulator consisting of four diodes and a transformer with the volt-ampere rating of 3.57% of the rectifier-rated power. Optimization of the transformer turns ratio is performed in order to minimize the input current total harmonic distortion (THD). It is shown that with the optimal turns ratio the input current THD equals 3.72%. Dependence of the input current THD on the load current is analyzed, and it is shown that at low load currents the rectifier operates in the discontinuous conduction mode with the THD of 7.79%. The analytical results are experimentally verified on a 2 kW rectifier, indicating that the input current THD lower than 8% is provided within a wide range of the load current variations applying simple circuitry.
The significance of one-station N2 disease in the prognosis of patients with nonsmall-cell lung cancer.

BACKGROUND
A retrospective study was conducted to define the characteristics and the prognosis of N2 disease subgroups according to their patterns of spread.


METHODS
From January 1993 to December 2004, 1,329 patients underwent lung resection for bronchogenic carcinoma The records of all patients with positive mediastinal lymph nodes at the surgical specimen (pIIIA/N2) after radical resection were analyzed, and the pattern of mediastinal lymphatic spread was classified according to regional spread, to skip metastasis, and to one or two or more lymph node stations, in relation to primary tumor location. Age, sex, type of resection, right or left lesion, T status, primary tumor location, tumor size, tumor central or peripheral location, histology, and survival were recorded and analyzed. Survival was analyzed according to regional spread or not, number of mediastinal lymph node stations involved, and skip metastasis status.


RESULTS
Among 302 cases (22.7%) with positive mediastinal lymph nodes pIIIA/N2, 66 (22%) were skip metastases, 72 (24%) had a nonregional mode of spread, and 199 (66%) included two or more stations of mediastinal lymph node invasion. Cox regression analysis of all cases disclosed malignant invasion in only one mediastinal lymph node station as the only favorable factor of survival (p < 0.001, odds ratio 0.57, 95% confidence interval: 0.42 to 0.78).


CONCLUSIONS
The presence of one-station mediastinal lymph node metastasis in patients with nonsmall-cell lung cancer who underwent major lung resection with complete mediastinal lymph node dissection proved to be a good prognostic factor that should be taken into account in the future.
Pilot study of adjuvant chemotherapy with 3-week combination of S-1 and cisplatin for patients with stage II-IV (M0) gastric cancer

Purpose The feasibility of a 3-week combination of S-1 and cisplatin as an adjuvant chemotherapy for patients with curatively resected gastric cancer was investigated. Experimental design Korean patients with stage II-IV (M0) gastric adenocarcinoma who underwent a gastrectomy with D2 lymph node resection were enrolled. The S-1 was administered orally at 80 mg/m2 divided into two daily doses for 14 days, while the cisplatin was administered at 60 mg/m2 intravenously over 2 h every 21 days. The patients received a maximum of six cycles. Results From January 2006 to July 2010, 74 patients were included in this study. The median patient age was 56 years (range, 22–71), and 51.4% (38/74) of the patients had a performance status of 0. The median number of chemotherapy cycles administered was 6 (range, 1–6). The median relative dose intensity was 86.4% for S-1 and 80.0% for cisplatin. With a median follow-up duration of 13.9 months, the median relapse-free survival (RFS) and overall survival (OS) have not yet been reached. Fifteen relapses (20.3%) were documented. Plus, the estimated RFS rate was 60.5% at 3 years. The treatments were generally well tolerated. The most frequently observed grade 3–4 hematological toxicity was neutropenia (35.1%), and only 1 cycle of neutropenic fever occurred. The most frequently observed grade 3–4 non-hematological toxicities were nausea (4.1%) and asthenia (4.1%), and all the other grade 3–4 non-hematological toxicities were observed in less than 3% of the patients. Conclusions Postoperative adjuvant S-1 plus cisplatin for 18 weeks was found to be feasible for patients with stage II-IV (M0) gastric adenocarcinoma following complete surgical resection.
A Study of Ultra-Thin Single Layer Frequency Selective Surface Microwave Absorbers With Three Different Bandwidths Using Double Resonance

In this paper, we present three ultra-thin frequency selective surface (FSS) microwave absorbers on a single layer, that have three remarkable features. First, the various absorbing bandwidths can be obtained in our absorber by adjusting the two absorbing peaks, which are produced by two different resonance effects on the FSS. By manipulating the dimension parameters, we design the dual-band, 3-dB and 10-dB band absorbers. We achieved the absorber's thickness of 0.039λg with the single layer due to high loss of inter-digital capacitor patterns on the FSS. Additionally, the proposed absorbers are insensitive to polarized electromagnetic (EM) waves because of the symmetric structure of the FSS. In this study, the absorber mechanism and transmission line (TL) modeling for the absorber design are studied. Each of the proposed absorbers is analyzed by using the TL equivalent circuit model and full-wave analysis. The loss factor is studied in order to demonstrate the origin of losses, and a parametric study is conducted to explain how to vary the absorbing bandwidths. The performances of each proposed absorber are also experimentally demonstrated.