LLukas22/scidocs huggingface dataset:
Emergency Portacaval Shunt Versus Rescue Portacaval Shunt in a Randomized Controlled Trial of Emergency Treatment of Acutely Bleeding Esophageal Varices in Cirrhosis—Part 3

Emergency treatment of bleeding esophageal varices in cirrhosis is of singular importance because of the high mortality rate. Emergency portacaval shunt is rarely used today because of the belief, unsubstantiated by long-term randomized trials, that it causes frequent portal-systemic encephalopathy and liver failure. Consequently, portacaval shunt has been relegated solely to salvage therapy when endoscopic and pharmacologic therapies have failed. Question: Is the regimen of endoscopic sclerotherapy with rescue portacaval shunt for failure to control bleeding varices superior to emergency portacaval shunt? A unique opportunity to answer this question was provided by a randomized controlled trial of endoscopic sclerotherapy versus emergency portacaval shunt conducted from 1988 to 2005. Unselected consecutive cirrhotic patients with acute bleeding esophageal varices were randomized to endoscopic sclerotherapy (n = 106) or emergency portacaval shunt (n = 105). Diagnostic workup was completed and treatment was initiated within 8 h. Failure of endoscopic sclerotherapy was defined by strict criteria and treated by rescue portacaval shunt (n = 50) whenever possible. Ninety-six percent of patients had more than 10 years of follow-up or until death. Comparison of emergency portacaval shunt and endoscopic sclerotherapy followed by rescue portacaval shunt showed the following differences in measurements of outcomes: (1) survival after 5 years (72% versus 22%), 10 years (46% versus 16%), and 15 years (46% versus 0%); (2) median post-shunt survival (6.18 versus 1.99 years); (3) mean requirements of packed red blood cell units (17.85 versus 27.80); (4) incidence of recurrent portal-systemic encephalopathy (15% versus 43%); (5) 5-year change in Child’s class showing improvement (59% versus 19%) or worsening (8% versus 44%); (6) mean quality of life points in which lower is better (13.89 versus 27.89); and (7) mean cost of care per year ($39,200 versus $216,700). These differences were highly significant in favor of emergency portacaval shunt (all p < 0.001). Emergency portacaval shunt was strikingly superior to endoscopic sclerotherapy as well as to the combination of endoscopic sclerotherapy and rescue portacaval shunt in regard to all outcome measures, specifically bleeding control, survival, incidence of portal-systemic encephalopathy, improvement in liver function, quality of life, and cost of care. These results strongly support the use of emergency portacaval shunt as the first line of emergency treatment of bleeding esophageal varices in cirrhosis.
Layering concepts in anterior composite restorations.

SUMMARY
With increasing patient demands for esthetic dentition, composite resin restorations enjoy great popularity due to excellent esthetics, acceptable longevity, and relatively low costs. Shading concepts used by manufacturers, however, may be confusing to many clinicians.


PURPOSE
To review and describe the current main shading concepts, evaluate their potential for creating natural esthetics, and provide guidelines for application.
5G C-RAN architecture: A comparison of multiple optical fronthaul networks

The development of the fifth generation (5G) wireless technology is in progress to address the increasing demands for high capacity, low latency, and ubiquitous mobile access instigated by next-generation mobile and machine-centric applications. The Centralized/Cloud-Radio Access Network (C-RAN) architecture exploiting the small-cell paradigm has been identified as a promising approach to address the benchmarks of 5G networks. However, providing a reliable, cost-effective, and quality of service guaranteed end-to-end connectivity is one of the major challenges in 5G C-RAN. To identify the suitability of a fronthaul technology to satisfy the unprecedented demands of future 5G wireless network in a cost-effective manner, different architecture and technologies need to be equitably compared in terms of all major requirements of 5G fronthaul network such as bandwidth requirements, delay budgets, deployment costs, complexity of radio remote head (RRH), and the ability to support advanced wireless functions. Therefore, in this paper, we equitably compare a multiple fronthaul architectures that can be used for 5G networks. In particular, we first analyze the stringent requirements of the 5G fronthaul network. Then, we investigate the applicability of three fronthaul technologies (PLS, ARoF, and CPRI) for the C-RAN architecture. We provide comparative analyses of these technologies by elaborating on their ability to fulfill 5G latency and capacity requirements, the complexity of RRH, and also to support advanced wireless features such as cooperative communication. To provide a well-balanced comparison of these fronthaul technologies, we also comparatively analyze the deployment costs of these architectures by developing an optimization framework to plan 5G C-RAN. Our analyses provide insights into how a future-proof fronthaul network can be modeled for 5G C-RAN.
Iron supplementation in HIV-infected Malawian children with anemia: a double-blind, randomized, controlled trial.

BACKGROUND
It is unknown whether iron supplementation in human immunodeficiency virus (HIV)-infected children living in regions with high infection pressure is safe or beneficial. A 2-arm, double-blind, randomized, controlled trial was conducted to examine the effects of iron supplementation on hemoglobin, HIV disease progression, and morbidity.


METHODS
HIV-infected Malawian children aged 6-59 months with moderate anemia (hemoglobin level, 7.0-9.9 g/dL) were randomly assigned to receive 3 mg/kg/day of elemental iron and multivitamins (vitamins A, C, and D) or multivitamins alone for 3 months. Participants were followed for 6 months.


RESULTS
A total of 209 children were randomly assigned to treatment, and 196 (93.8%) completed 6 months of follow-up. Iron supplementation was associated with greater increases in hemoglobin concentrations (adjusted mean difference [aMD], 0.60; 95% confidence interval [CI], .06-1.13; P = .03) and reduced the risk of anemia persisting for up to 6 months follow-up (adjusted prevalence ratio, 0.59; 95% CI, .38-.92; P = .02). Children who received iron had a better CD4 percentage response at 3 months (aMD, 6.00; 95% CI, 1.84-10.16; P = .005) but an increased incidence of malaria at 6 months (incidence rate, 120.2 vs 71.7; adjusted incidence rate ratio [aIRR], 1.81 [95% CI, 1.04-3.16]; P = .04), especially during the first 3 months (incidence rate, 78.1 vs 36.0; aIRR, 2.68 [95% CI, 1.08-6.63]; P = .03).


CONCLUSIONS
Iron supplementation in anemic HIV-infected children has beneficial effects on hemoglobin, anemia, and immunity but increases the risk of malaria. Thus, iron supplementation in HIV-infected children living in malaria-endemic areas should only be provided in combination with adequate protection from malaria.


CLINICAL TRIALS REGISTRATION
ISRCTN-62947977.
19q13.11 deletion syndrome: a novel clinically recognisable genetic condition identified by array comparative genomic hybridisation.

BACKGROUND
Deletions of chromosome 19 have rarely been reported, with the exception of some patients with deletion 19q13.2 and Blackfan-Diamond syndrome due to haploinsufficiency of the RPS19 gene. Such a paucity of patients might be due to the difficulty in detecting a small rearrangement on this chromosome that lacks a distinct banding pattern. Array comparative genomic hybridisation (CGH) has become a powerful tool for the detection of microdeletions and microduplications at high resolution in patients with syndromic mental retardation.


METHODS AND RESULTS
Using array CGH, this study identified three interstitial overlapping 19q13.11 deletions, defining a minimal critical region of 2.87 Mb, associated with a clinically recognisable syndrome. The three patients share several major features including: pre- and postnatal growth retardation with slender habitus, severe postnatal feeding difficulties, microcephaly, hypospadias, signs of ectodermal dysplasia, and cutis aplasia over the posterior occiput. Interestingly, these clinical features have also been described in a previously reported patient with a 19q12q13.1 deletion. No recurrent breakpoints were identified in our patients, suggesting that no-allelic homologous recombination mechanism is not involved in these rearrangements.


CONCLUSIONS
Based on these results, the authors suggest that this chromosomal abnormality may represent a novel clinically recognisable microdeletion syndrome caused by haploinsufficiency of dosage sensitive genes in the 19q13.11 region.
Autonomous ultra-low power DC/DC converter for Microbial Fuel Cells

In this paper, an ultra-low voltage and power DC/DC converter is presented. This converter harvests energy from a Microbial Fuel Cell (MFC) in order to feed another circuit such as an autonomous wireless sensor. The MFC behaves as a voltage generator of 475mV open-circuit voltage with a 600Ω serial internal impedance. The maximum delivered power is therefore around 100μW. The DC/DC converter provides output voltage in the range 2–7.5V and performs impedance matching with source. The converter achieves when associated with the MFC, 60% peak efficiency. Furthermore, this DC/DC converter is self-operating without the need for external power source of start-up assistance.
Intermediate stage Hodgkin's disease: preliminary results on 210 patients treated with four ABVD chemotherapy cycles plus extended versus involved field radiotherapy.

BACKGROUND
To improve long-term survival by reducing toxicity in intermediate stage Hodgkin's disease patients, we compared the effects of involved field (IF) versus extended field (EF) irradiation administered after four cycles of ABVD regimen.


MATERIALS AND METHODS
Two hundred and ten Hodgkin's disease patients, at clinical stage II with risk factors and III without risk factors, were enrolled in the randomized study HD94. After four courses of ABVD regimen, patients who achieved complete remission (CR) or partial remission (PR) were randomly assigned to the IF or EF arm. The Kaplan-Meier method was adopted to estimate overall survival (OS) and relapse-free survival (RFS).


RESULTS
After a median follow-up of 78 months (range 13-111 months), OS was 98% and 96%, respectively, in the EF and IF arms; RFS was 94% and 91%, respectively, in the EF and IF arms.


CONCLUSION
We confirm the efficacy of four cycles of ABVD regimen, with suitable dose intensity, and radiotherapy as consolidation therapy, in intermediate stage Hodgkin's disease patients (CR = 99.5% and OS = 95%). We also found that involved field radiotherapy results were as effective as extended field, without acute toxicity.
Blockchain in internet of things: Challenges and Solutions

The Internet of Things (IoT) is experiencing exponential growth in research and industry, but it still suffers from privacy and security vulnerabilities. Conventional security and privacy approaches tend to be inapplicable for IoT, mainly due to its decentralized topology and the resource-constraints of the majority of its devices. BlockChain (BC) that underpin the cryptocurrency Bitcoin have been recently used to provide security and privacy in peer-to-peer networks with similar topologies to IoT. However, BCs are computationally expensive and involve high bandwidth overhead and delays, which are not suitable for IoT devices. This position paper proposes a new secure, private, and lightweight architecture for IoT, based on BC technology that eliminates the overhead of BC while maintaining most of its security and privacy benefits. The described method is investigated on a smart home application as a representative case study for broader IoT applications. The proposed architecture is hierarchical, and consists of smart homes, an overlay network and cloud storages coordinating data transactions with BC to provide privacy and security. Our design uses different types of BC’s depending on where in the network hierarchy a transaction occurs, and uses distributed trust methods to ensure a decentralized topology. Qualitative evaluation of the architecture under common threat models highlights its effectiveness in providing security and privacy for IoT applications.
Functioning in middle aged and older patients with schizophrenia and depressive symptoms: relationship to psychopathology.

BACKGROUND
Depressive symptoms are common in middle aged and older patients with schizophrenia. The authors hypothesized that worse functioning in these patients would be associated with worse psychopathology.


METHODS
Outpatients with schizophrenia were > or =40 years old with subsyndromal depression and Hamilton Depression Rating Scale Scores of > or =8. Exclusions were dementia, two months of either mania or major depression or 1 month active substance abuse/dependence. The authors administered performance based functional assessments, the Positive and Negative Syndrome Scale of Schizophrenia [PANSS], and Calgary Depression Rating Scale.


RESULTS
PANSS (-) scores were negatively correlated with the UCSD Performance Skills Based Assessment, Social Skills Performance Assessment and Medication Management Ability Assessment total error (MMAA) scores. Digit symbol scores served as a moderator of the relationship between MMAA and PANSS (-) scores.


CONCLUSIONS
Negative symptoms were associated with functioning. The relationship between negative symptoms and medication errors seem to weaken in subjects with quicker processing speed.
PTZ camera based position tracking in IP-surveillance system

Tracking people or moving objects across a PTZ camera and maintaining a track within a camera is a challenging task in applications of video surveillance. In this paper we propose a novel object positioning tracking framework, PTZ camera based position tracking system, which is also known as PCTS, can help estimate the position of an object by using camera parameters, pan and tilt. From object motion vector, the relevant information such as time, background and geographic parameters can be recorded in database as well. In the experiment, the change of a personpsila position is recorded by the PTZ camera in real time. The PCTS provides a feasible solution for position analysis and security surveillance services in future.
Efficacy of nerve root versus interspinous injections of glucocorticoids in the treatment of disk-related sciatica. A pilot, prospective, randomized, double-blind study.

STUDY OBJECTIVES
Pilot study comparing the short-term efficacy on pain and functional impairment of nerve root sheath versus interspinous glucocorticoid injections in patients admitted to a French rheumatology department for disk-related sciatica or femoral neuralgia.


PATIENTS AND METHODS
Thirty patients with refractory nerve root pain (sciatica, n = 29; femoral neuralgia, n = 1) for a mean of four months were randomized to nerve root injection (n = 17) or interspinous injection (n = 13) of the same mixture of 0.10 g of lidocaine hydrochloride and 3.75 mg of cortivazol. Both injection methods were performed under analgesia and benzodiazepine sedation to maintain double blinding. Each patient was evaluated daily during the first seven days of bed rest in the hospital, then after discharge on postinjection day 28.


RESULTS
Prompt pain relief was obtained in both groups. On day 1, the mean pain scale score (0-100) fell from 70 +/- 3.9 to 26 +/- 5.6 in the nerve root group and from 63 +/- 4 to 23 +/- 4.7 in the interspinous group. These results were sustained on D7 and D28.


CONCLUSIONS
The unusually high level of efficacy of glucocorticoid injection in our study may be ascribable in part to strong placebo and Hawthorne effects and in part to the intrinsic effects of the injections. Whether nerve root injection is superior over interspinous injection remains unproven.
Validation of the AVITA BPM15S wrist blood pressure monitor for home blood pressure monitoring according to the European Society of Hypertension International Protocol revision 2010.

OBJECTIVE
The present study aimed to evaluate the accuracy of the automated oscillometric wrist blood pressure monitor AVITA BPM15S for home blood pressure monitoring according to the International Protocol revision 2010 of the European Society of Hypertension.


METHOD
Systolic and diastolic blood pressures were sequentially measured in 33 Chinese adults (15 women, mean age 51 years) using a mercury sphygmomanometer (two observers) and the AVITA BPM15S device (one supervisor). Ninety-nine pairs of comparisons were obtained from 33 participants for judgments in two parts with three grading phases.


RESULTS
The AVITA BPM15S device achieved the targets in part 1 of the validation study. The number of absolute differences between the device and observers within 5, 10, and 15 mmHg were 85/99, 94/99, and 98/99, respectively, for systolic blood pressure, and 82/99, 96/99, and 98/99, respectively, for diastolic blood pressure. The device also achieved the criteria in part 2 of the validation study. Thirty-two and 28 participants for systolic and diastolic blood pressure, respectively, had at least two of the three device-observer differences within 5 mmHg (required ≥ 24). No participant had all of the three device-observer comparisons greater than 5 mmHg for systolic or diastolic blood pressure.


CONCLUSION
The AVITA wrist blood pressure monitor BPM15S fulfilled the requirements of the International Protocol revision 2010 and hence can be recommended for home use in an adult population.
Learning to extract information from semi-structured text using a discriminative context free grammar

In recent work, conditional Markov chain models (CMM) have been used to extract information from semi-structured text (one example is the Conditional Random Field [10]). Applications range from finding the author and title in research papers to finding the phone number and street address in a web page. The CMM framework combines a priori knowledge encoded as features with a set of labeled training data to learn an efficient extraction process. We will show that similar problems can be solved more effectively by learning a discriminative context free grammar from training data. The grammar has several distinct advantages: long range, even global, constraints can be used to disambiguate entity labels; training data is used more efficiently; and a set of new more powerful features can be introduced. The grammar based approach also results in semantic information (encoded in the form of a parse tree) which could be used for IR applications like question answering. The specific problem we consider is of extracting personal contact, or address, information from unstructured sources such as documents and emails. While linear-chain CMMs perform reasonably well on this task, we show that a statistical parsing approach results in a 50% reduction in error rate. This system also has the advantage of being interactive, similar to the system described in [9]. In cases where there are multiple errors, a single user correction can be propagated to correct multiple errors automatically. Using a discriminatively trained grammar, 93.71% of all tokens are labeled correctly (compared to 88.43% for a CMM) and 72.87% of records have all tokens labeled correctly (compared to 45.29% for the CMM).
A pilot study to establish a clinical model to perform phase II studies of breast cancer chemopreventive agents in women at high risk with biomarkers as surrogate endpoints for activity.

PURPOSE
Use of surrogate end point biomarkers in phase II trials may help select agents that appear to have activity and might be evaluated in future phase III definitive trials of breast cancer prevention. We performed a pilot clinical trial to establish the logistics for a clinical model to perform phase II studies of breast cancer chemopreventive agents in women at high risk with novel imaging techniques and candidate surrogate end point biomarkers for activity. We chose tamoxifen to establish proof of principal with a known effective agent.


EXPERIMENTAL DESIGN
Women at a high risk of developing a new breast cancer and for whom tamoxifen was recommended were eligible. The women underwent baseline and 3 and 6 months mammogram and magnetic resonance imaging (MRI) of one breast to identify areas of water-like intensity (epithelial) and to determine the changes over time and MRI-directed core breast biopsies of these areas for surrogate end point biomarkers analysis.


RESULTS
From August 1999 to March 2001, 26 women underwent baseline imaging and core biopsies. Sixteen women took tamoxifen and 10 chose not to. Overall, 79% of the samples contained glandular tissue evaluable for histology, but only 66% of the samples were evaluable for marker analysis. Only 12 patients had specimens with glandular tissue sufficient for marker analysis both at baseline and in at least one follow-up. Because of the small number of women with matched samples, marker analysis was not informative.


CONCLUSIONS
This study shows the feasibility of obtaining serial core breast biopsies from women at a high risk of developing a new breast cancer. Patient participation in this model is satisfactory, and such a model may provide indication of drug activity. MRI-directed biopsy did not provide a high yield of evaluable samples, and additional work on adequate collection of epithelial tissue for surrogate end point biomarker analysis is thus necessary.
Fast and Stable Color Balancing for Images and Augmented Reality

This paper addresses the problem of globally balancing colors between images. The input to our algorithm is a sparse set of desired color correspondences between a source and a target image. The global color space transformation problem is then solved by computing a smooth vector field in CIE Lab color space that maps the gamut of the source to that of the target. We employ normalized radial basis functions for which we compute optimized shape parameters based on the input images, allowing for more faithful and flexible color matching compared to existing RBF-, regression- or histogram-based techniques. Furthermore, we show how the basic per-image matching can be efficiently and robustly extended to the temporal domain using RANSAC-based correspondence classification. Besides interactive color balancing for images, these properties render our method extremely useful for automatic, consistent embedding of synthetic graphics in video, as required by applications such as augmented reality.
Fast unfolding of community hierarchies in large networks

Introduction The typical size of large networks such as social network services, mobile phone networks or the web now counts in millions when not billions of nodes and these scales demand new methods to retrieve comprehensive information from their structure. A promising approach consists in decomposing the networks into communities of strongly connected nodes, with the nodes belonging to different communities only sparsely connected. Finding exact optimal partitions in networks is known to be computationally intractable, mainly due to the explosion of the number of possible partitions as the number of nodes increases. It is therefore of high interest to propose algorithms to find reasonably “good” solutions of the problem in a reasonably “fast” way. One of the fastest algorithms consists in optimizing the modularity of the partition in a greedy way (Clauset et al, 2004), a method that, even improved, does not allow to analyze more than a few millions nodes (Wakita et al, 2007).