LLukas22/scidocs huggingface dataset:
Effects of meals rich in either monounsaturated or saturated fat on lipid concentrations and on insulin secretion and action in subjects with high fasting triglyceride concentrations.

BACKGROUND
The nature of dietary fats and fasting concentrations of triglycerides affect postprandial hypertriglyceridemia and glucose homeostasis.


OBJECTIVES
The objectives were to examine the effects of meals enriched in monounsaturated fatty acids (MUFAs) or saturated fatty acids (SFAs) on postprandial lipid, glucose, and insulin concentrations and to examine the extent of β cell function and insulin sensitivity in subjects with high fasting triglyceride concentrations.


DESIGN
Fourteen men with fasting hypertriglyceridemia and normal glucose tolerance were given meals (≈10 kcal/kg body weight) containing MUFAs, SFAs, or no fat. Blood samples were collected at baseline and hourly over 8 h for analysis.


RESULTS
The high-fat meals significantly increased postprandial concentrations of triglycerides, nonesterified fatty acids, and insulin and postprandial indexes of β cell function. However, postprandial indexes of insulin sensitivity decreased significantly. These effects were significantly attenuated with MUFAs relative to SFAs.


CONCLUSIONS
MUFAs postprandially buffered β cell hyperactivity and insulin intolerance relative to SFAs in subjects with high fasting triglyceride concentrations. These data suggest that, in contrast with SFAs, MUFA-based strategies may provide cardiovascular benefits to persons at risk by limiting lipid and insulin excursions and may contribute to optimal glycemic control after meal challenges.
Securing web applications from injection and logic vulnerabilities: Approaches and challenges

Context: Web applications are trusted by billions of users for performing day-to-day activities. Accessibility, availability and omnipresence of web applications have made them a prime target for attackers. A simple implementation flaw in the application could allow an attacker to steal sensitive information and perform adversary actions, and hence it is important to secure web applications from attacks. Defensive mechanisms for securing web applications from the flaws have received attention from both academia and industry. Objective: The objective of this literature review is to summarize the current state of the art for securing web applications from major flaws such as injection and logic flaws. Though different kinds of injection flaws exist, the scope is restricted to SQL Injection (SQLI) and Cross-site scripting (XSS), since they are rated as the top most threats by different security consortiums. Method: The relevant articles recently published are identified from well-known digital libraries, and a total of 86 primary studies are considered. A total of 17 articles related to SQLI, 35 related to XSS and 34 related to logic flaws are discussed. Results: The articles are categorized based on the phase of software development life cycle where the defense mechanism is put into place. Most of the articles focus on detecting the flaws and preventing attacks against web applications. Conclusion: Even though various approaches are available for securing web applications from SQLI and XSS, they are still prevalent due to their impact and severity. Logic flaws are gaining attention of the researchers since they violate the business specifications of applications. There is no single solution to mitigate all the flaws. More research is needed in the area of fixing flaws in the source code of applications.
Rationale and design of the Kanyini guidelines adherence with the polypill (Kanyini-GAP) study: a randomised controlled trial of a polypill-based strategy amongst Indigenous and non Indigenous people at high cardiovascular risk

BACKGROUND
The Kanyini Guidelines Adherence with the Polypill (Kanyini-GAP) Study aims to examine whether a polypill-based strategy (using a single capsule containing aspirin, a statin and two blood pressure-lowering agents) amongst Indigenous and non-Indigenous people at high risk of experiencing a cardiovascular event will improve adherence to guideline-indicated therapies, and lower blood pressure and cholesterol levels.


METHODS/DESIGN
The study is an open, randomised, controlled, multi-centre trial involving 1000 participants at high risk of cardiovascular events recruited from mainstream general practices and Aboriginal Medical Services, followed for an average of 18 months. The participants will be randomised to one of two versions of the polypill, the version chosen by the treating health professional according to clinical features of the patient, or to usual care. The primary study outcomes will be changes, from baseline measures, in serum cholesterol and systolic blood pressure and self-reported current use of aspirin, a statin and at least two blood pressure lowering agents. Secondary study outcomes include cardiovascular events, renal outcomes, self-reported barriers to indicated therapy, prescription of indicated therapy, occurrence of serious adverse events and changes in quality-of-life. The trial will be supplemented by formal economic and process evaluations.


DISCUSSION
The Kanyini-GAP trial will provide new evidence as to whether or not a polypill-based strategy improves adherence to effective cardiovascular medications amongst individuals in whom these treatments are indicated.


TRIAL REGISTRATION
This trial is registered with the Australian New Zealand Clinical Trial Registry ACTRN126080005833347.
Effect of erythropoietin on exercise capacity in patients with moderate to severe chronic heart failure.

BACKGROUND
Patients with chronic heart failure (CHF) are frequently anemic. An increase in hemoglobin could enhance exercise performance by increasing oxygen delivery. We investigated the effect of erythropoietin (EPO) on exercise performance in anemic patients with CHF.


METHODS AND RESULTS
Twenty-six anemic patients aged 57+/-11 years were randomized to receive EPO (15 000 to 30 000 IU per week) or placebo for 3 months. Parameters measured at baseline and end therapy included blood parameters (hemoglobin, hematocrit, plasma volume), exercise parameters (peak oxygen consumption [VO2], exercise duration, 6-minute walk), muscle aerobic metabolism (half-time of VO2 and near infrared recovery), and forearm vasodilatory function. EPO was well tolerated by all patients. Twelve patients in the EPO group felt improvement versus 1 in the placebo group (P<0.05). There were significant increases in hemoglobin (11.0+/-0.5 to 14.3+/-1.0 g/dL, P<0.05), peak VO2 (11.0+/-1.8 to 12.7+/-2.8 mL. min(-1) x kg(-1), P<0.05) and exercise duration (590+/-107 to 657+/-119 s, P<0.004) in the EPO group but no significant changes in the control group. Resting and hyperemic forearm vascular resistance and indices of the rate of muscle oxidative capacity were unchanged in both groups.


CONCLUSION
EPO significantly enhances exercise capacity in patients with CHF. One mechanism of improvement in VO2 is increased oxygen delivery from increased hemoglobin concentration.
Analysis of the EEG Signal for a Practical Biometric System

This paper discusses the effectiveness of the EEG signal for human identification using four or less of channels of two different types of EEG recordings. Studies have shown that the EEG signal has biometric potential because signal varies from person to person and impossible to replicate and steal. Data were collected from 10 male subjects while resting with eyes open and eyes closed in 5 separate sessions conducted over a course of two weeks. Features were extracted using the wavelet packet decomposition and analyzed to obtain the feature vectors. Subsequently, the neural networks algorithm was used to classify the feature vectors. Results show that, whether or not the subjects’ eyes were open are insignificant for a 4– channel biometrics system with a classification rate of 81%. However, for a 2–channel system, the P4 channel should not be included if data is acquired with the subjects’ eyes open. It was observed that for 2– channel system using only the C3 and C4 channels, a classification rate of 71% was achieved. Keywords—Biometric, EEG, Wavelet Packet Decomposition, Neural Networks
Evaluating spatiotemporal interest point features for depth-based action recognition

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Use of cytomegalovirus intravenous immune globulin for the adjunctive treatment of cytomegalovirus in hematopoietic stem cell transplant recipients.

STUDY OBJECTIVE
To describe the characteristics and clinical outcomes of hematopoietic stem cell transplant (HSCT) recipients who received adjunctive cytomegalovirus intravenous immune globulin (CMV-IVIG) for probable or proven CMV disease.


DESIGN
Retrospective cohort study.


SETTING
Large, university-affiliated, tertiary-care medical center.


PATIENTS
Thirty-five adult HSCT recipients who received at least one dose of CMV-IVIG for adjunctive treatment of probable or proven CMV disease between January 1, 1999, and December 31, 2007.


MEASUREMENTS AND MAIN RESULTS
All-cause mortality at hospital discharge was the primary outcome. All patients received an allogeneic HSCT. Twenty-six patients (74%) had pneumonitis, nine (26%) had enteritis, and 29 (83%) had CMV viremia. All patients received concomitant antiviral therapy; 31 (89%) received ganciclovir, and 14 (40%) received foscarnet. All-cause mortality at hospital discharge was 49% (17 patients). Patient characteristics associated with mortality included requiring intubation for CMV pneumonia (11 [79%] of 14 nonsurvivors vs 3 (25%) of 12 survivors, p=0.016) and earlier disease onset after HSCT (median 48 days for nonsurvivors vs 106 days for survivors, p<0.001). In the multivariate analysis, only requiring intubation for CMV pneumonia remained a significant risk factor for increased mortality. A low rate of adverse events was attributed to CMV-IVIG, with mild hypertension (two patients [6%]) and erythema and chills (one patient [3%]) being the most common.


CONCLUSION
The mortality rate in our study population was similar to previous reports in the literature and may be somewhat lower than rates reported with antiviral monotherapy. Our analysis suggests that factors associated with mortality include the need for intubation and, possibly, earlier onset of CMV disease after HSCT. Treatment with CMV-IVIG appears to be well tolerated in HSCT recipients. These findings support further trials of CMV-IVIG efficacy in this setting.
Developments of fuzzy PID controllers

This paper describes the development and tuning methods for a novel self-organizing fuzzy proportional integral derivative (PID) controller. Before applying fuzzy logic, the PID gains are tuned using a conventional tuning method. At supervisory level, fuzzy logic readjusts the PID gains online. In the first tuning method, fuzzy logic at the supervisory level readjusts the three PID gains during the system operation. In the second tuning method, fuzzy logic only readjusts the proportional PID gain, and the corresponding integral and derivative gains are readjusted using the Ziegler–Nichols tuning method while the system is in operation. For the compositional rule of inferences in the fuzzy PID and the self-organizing fuzzy PID schemes two new approaches are introduced: the min implication function with the mean of maxima defuzzification method, and the max-product implication function with the centre of gravity defuzzification method. The fuzzy PID controller, the self-organizing fuzzy PID controller and the PID controller are all applied to a non-linear revolute-joint robot arm for step input and path tracking experiments using computer simulation. For the step input and path tracking experiments, the novel self-organizing fuzzy PID controller produces a better output response than the fuzzy PID controller; and in turn both controllers exhibit better process output than the PID controller.
Sudden quadriplegia after acute cervical disc herniation.

BACKGROUND
Acute neurological deterioration secondary to cervical disc herniation not related to external trauma is very rare, with only six published reports to date. In most cases, acute symptoms were due to progression of disc herniation in the presence of pre-existing spinal canal stenosis.


CASE REPORT
A 42-year-old man developed weakness and numbness in his arms and legs immediately following a sneeze. On physical examination he had upper motor neuron signs that progressed over a few hours to a complete C5 quadriplegia. An emergent magnetic resonance imaging study revealed a massive C4/5 disc herniation. He underwent emergency anterior cervical discectomy and fusion. Postoperatively, the patient remained quadriplegic. Eighteen days later, while receiving rehabilitation therapy, he expired secondary to a pulmonary embolus. Autopsy confirmed complete surgical decompression of the spinal cord.


CONCLUSIONS
Our case demonstrates that acute quadriplegia secondary to cervical disc herniation may occur without a history of myelopathy or spinal canal stenosis after an event as benign as a sneeze.
Numerical simulation of instantaneous backflow through central clearance of bileaflet mechanical heart valves at closure: shear stress and pressure fields within clearance

Instantaneous backflow through central clearance of bileaflet heart valves at the instant of closure is investigated. An Edwards-Duromedics valve in the mitral position is employed to measure the transient pressures near the entrance and exit region in an in vitro flow chamber. A region surrounding the clearance is modelled, and two-dimensional quasi-steady-state numerical simulations are performed, with the measured transient pressure difference across the clearance as a driving force for the flow. The results show that pressure difference several times larger than the driving pressure used to close the valve is established across the clearance for about 0·5 ms at the moment of closure. The resulting average wall shear stress is an order of magnitude larger than the turbulent Reynolds stresses reported distal to the valve during opening. A local jump in the shear stress distribution and fall in the pressure distribution are observed at the entrance region. Rounding of the corners in the channel entrance attenuates these spikes. The results of the study indicate that backflow through clearance at closure may be one reason for the haemolysis and thrombosis associated with mechanical heart valves, despite the short duration of the flow field.
Reports of repetitive penile-genital penetration often have no definitive evidence of penetration.

OBJECTIVES
The goals were to evaluate the association of definitive hymenal findings with the number of reported episodes of penile-genital penetration, pain, bleeding, dysuria, and time since assault for girls presenting for nonacute, sexual assault examinations.


METHODS
Charts of all girls 5 to 17 of age who provided a history of nonacute, penile-genital, penetrative abuse were reviewed. Interviews and examinations occurred over a 4-year period at a children's advocacy center. Characteristics of the histories provided by the subjects were examined for associations with definitive findings of penetrative trauma.


RESULTS
Five hundred six patients were included in the study. Of the 56 children with definitive examination results, 52 had no history of consensual penile-vaginal intercourse and all were > or =10 years of age. Analysis was unable to detect an association between the number of reported penile-genital penetrative events and definitive genital findings. Eighty-seven percent of victims who provided a history of >10 penetrative events had no definitive evidence of penetration. A history of bleeding with abuse was more than twice as likely for subjects with definitive findings. Children <10 years of age were twice as likely to report >10 penetrative events, although none had definitive findings on examination.


CONCLUSIONS
Most victims who reported repetitive penile-genital contact that involved some degree of perceived penetration had no definitive evidence of penetration on examination of the hymen. Similar results were seen for victims of repetitive assaults involving perceived penetration over long periods of time, as well as victims with a history of consensual sex.
Land-use and land-cover change in Atlantic Forest landscapes

The Atlantic Forest is one of the most threatened tropical biomes, with much of the standing forest in small (less than 50 ha), disturbed and isolated patches. The pattern of land-use and land-cover change (LULCC) which has resulted in this critical scenario has not yet been fully investigated. Here, we describe the LULCC in three Atlantic Forest fragmented landscapes (São Paulo, Brazil) between 1960–1980s and 1980–2000s. The three studied landscapes differ in the current proportion of forest cover, having 10%, 30% and 50% respectively. Between the 1960s and 1980s, forest cover of two landscapes was reduced while the forest cover in the third landscape increased slightly. The opposite trend was observed between the 1980s and 2000s; forest regeneration was greater than deforestation at the landscapes with 10% and 50% of forest cover and, as a consequence, forest cover increased. By contrast, the percentage of forest cover at the landscape with 30% of forest cover was drastically reduced between the 1980s and 2000s. LULCC deviated from a random trajectory, were not constant through time in two study landscapes and were not constant across space in a given time period. This landscape dynamism in single locations over small temporal scales is a key factor to be considered in models of LULCC to accurately simulate future changes for the Atlantic Forest. In general, forest patches became more isolated when deforestation was greater than forest regeneration and became more connected when forest regeneration was greater than deforestation. As a result of the dynamic experienced by the study landscapes, individual forest patches currently consist of a mosaic of different forest age classes which is likely to impact biodiversity. Furthermore, landscape dynamics suggests the beginning of a forest transition in some Atlantic Forest regions, what could be of great importance for biodiversity conservation due to the potential effects of young secondary forests in reducing forest isolation and maintaining a significant amount of the original biodiversity. 2012 Elsevier B.V. All rights reserved.
Anterior skull base surgery: open versus endoscopic.

PURPOSE OF REVIEW
Anterior cranial base surgery is undergoing a revolution in minimally invasive techniques. Both open, microscopic and transnasal endoscopic approaches have gained considerable attention in the last few years. The purpose of the current article is to evaluate recent advances in open and endoscopic approaches to the anterior skull base.


RECENT FINDINGS
Recent data have evaluated the endoscopic anatomy of the skull base, defined surgical corridors, addressed anatomical limitations to endoscopic skull base surgery, and discussed the limitations of skull base reconstruction. Over the same period of time, new surgical transcranial approaches have challenged the traditional operative corridors to the anterior skull base. In this study, the most recently published data pertaining to open and endoscopic approaches to the anterior cranial base are reviewed.


SUMMARY
The data provide support for both open and endoscopic approaches to the anterior cranial base. Limitations to the approaches are discussed.
Outcome of intensive immunosuppression and autologous stem cell transplantation in patients with severe rheumatoid arthritis is associated with the composition of synovial T cell infiltration.

OBJECTIVE
To determine clinical and immunological correlates of high dose chemotherapy (HDC) + autologous stem cell transplantation (ASCT) in patients with severe rheumatoid arthritis (RA), refractory to conventional treatment.


METHODS
Serial samples of peripheral blood and synovial tissue were obtained from seven patients with RA treated with HDC and autologous peripheral blood grafts enriched for CD34+ cells. Disease activity was assessed with the Disease Activity Score (DAS), serum concentrations of C reactive protein (CRP), and human immunoglobulin (HIg) scans, and the extent of immunoablation was determined by immunophenotyping of peripheral blood mononuclear cells, and immunohistochemistry and double immunofluorescence of synovium.


RESULTS
Clinical responders (n = 5) had a larger number of cells at baseline expressing CD3, CD4, CD27, CD45RA, CD45RB, and CD45RO in synovium (p < 0.05), higher activity on HIg scans (p = 0.08), and a trend towards higher concentrations of CRP in serum than non-responders (n = 2). Subsequent remissions and relapses in responders paralleled reduction and re-expression, respectively, of T cell markers. A relatively increased expression of CD45RB and CD45RO on synovial CD3+ T cells was seen after HDC + ASCT. No correlations were found between DAS and changes in B cells or macrophage infiltration or synoviocytes.


CONCLUSIONS
HDC + ASCT results in profound but incomplete immunoablation of both the memory and naïve T cell compartment, which is associated with longlasting clinical responses in most patients. The findings provide strong circumstantial evidence for a role of T cells in established RA, and demonstrate a role for the synovium in post-transplantation T cell reconstitution.
Activation of persons living with HIV for treatment, the great study

BACKGROUND
Patient empowerment represents a potent tool for addressing racial, ethnic and socioeconomic disparities in health care, particularly for chronic conditions such as HIV infection that require active patient engagement. This multimodal intervention, developed in concert with HIV patients and clinicians, aims to provide HIV patients with the knowledge, skills, attitudes and tools to become more activated patients.


METHODS/DESIGN
Randomized controlled trial of a multimodal intervention designed to activate persons living with HIV. The intervention includes four components: 1) use of a web-enabled hand-held device (Apple iPod Touch) loaded with a Personal Health Record (ePHR) customized for HIV patients; 2) six 90-minute group-based training sessions in use of the device, internet and the ePHR; 3) a pre-visit coaching session; and 4) clinician education regarding how they can support activated patients. Outcome measures include pre- post changes in patient activation measure score (primary outcome), eHealth literacy, patient involvement in decision-making and care, medication adherence, preventive care, and HIV Viral Load.


DISCUSSION
We hypothesize that participants receiving the intervention will show greater improvement in empowerment and the intervention will reduce disparities in study outcomes. Disparities in these measures will be smaller than those in the usual care group. Findings have implications for activating persons living with HIV and for other marginalized groups living with chronic illness.


TRIAL REGISTRATION
ClinicalTrials.gov Identifier: NCT02165735, 6/13/2014.
Research of Improved FP-Growth Algorithm in Association Rules Mining

Association rules mining is an important technology in data mining. FP-Growth (frequent-pattern growth) algorithm is a classical algorithm in association rules mining. But the FP-Growth algorithm in mining needs two times to scan database, which reduces the efficiency of algorithm. Through the study of association rules mining and FP-Growth algorithm, we worked out improved algorithms of FP-Growth algorithm—Painting-Growth algorithm and N (not) Painting-Growth algorithm (removes the painting steps, and uses another way to achieve). We compared two kinds of improved algorithms with FP-Growth algorithm. Experimental results show that Painting-Growth algorithm ismore than 1050 andNPainting-Growth algorithm is less than 10000 in data volume; the performance of the two kinds of improved algorithms is better than that of FP-Growth algorithm.