LLukas22/scidocs huggingface dataset:
Seroprevalence of herpes simplex virus types 1 and 2--United States, 1999-2010.

BACKGROUND
Herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) are common infections with serious sequelae. HSV-1 is an increasingly important cause of genital herpes in industrialized countries.


METHODS
Using nationally representative data from the National Health and Nutrition Examination Survey (NHANES), we examined HSV-1 and HSV-2 seroprevalence among 14- to 49-year-olds in the United States. We estimated seroprevalence in 1999-2004 and 2005-2010, stratified by sociodemographic characteristics and sexual behaviors. We also reviewed HSV-1 and HSV-2 seroprevalence from 1976-1980 to 2005-2010.


RESULTS
In 2005-2010, the seroprevalence of HSV-1 was 53.9%, and the seroprevalence of HSV-2 was 15.7%. From 1999-2004 to 2005-2010, HSV-1 seroprevalence declined by nearly 7% (P < .01), but HSV-2 seroprevalence did not change significantly. The largest decline in HSV-1 seroprevalence from 1999-2004 to 2005-2010 was observed among adolescents aged 14-19 years, among whom seroprevalence declined by nearly 23%, from 39.0% to 30.1% (P < .01). In this age group, HSV-1 seroprevalence declined >29% from 1976-1980 to 2005-2010 (P < .01).


CONCLUSIONS
An increasing number of adolescents lack HSV-1 antibodies at sexual debut. In the absence of declines in HSV-2 infections, the prevalence of genital herpes may increase.
Stochastic Gradient Descent Tricks

Chapter 1 strongly advocates the stochastic back-propagation method to train neural networks. This is in fact an instance of a more general technique called stochastic gradient descent (SGD). This chapter provides background material, explains why SGD is a good learning algorithm when the training set is large, and provides useful recommendations.
Opportunities and challenges in developing risk prediction models with electronic health records data: a systematic review

OBJECTIVE
Electronic health records (EHRs) are an increasingly common data source for clinical risk prediction, presenting both unique analytic opportunities and challenges. We sought to evaluate the current state of EHR based risk prediction modeling through a systematic review of clinical prediction studies using EHR data.


METHODS
We searched PubMed for articles that reported on the use of an EHR to develop a risk prediction model from 2009 to 2014. Articles were extracted by two reviewers, and we abstracted information on study design, use of EHR data, model building, and performance from each publication and supplementary documentation.


RESULTS
We identified 107 articles from 15 different countries. Studies were generally very large (median sample size = 26 100) and utilized a diverse array of predictors. Most used validation techniques (n = 94 of 107) and reported model coefficients for reproducibility (n = 83). However, studies did not fully leverage the breadth of EHR data, as they uncommonly used longitudinal information (n = 37) and employed relatively few predictor variables (median = 27 variables). Less than half of the studies were multicenter (n = 50) and only 26 performed validation across sites. Many studies did not fully address biases of EHR data such as missing data or loss to follow-up. Average c-statistics for different outcomes were: mortality (0.84), clinical prediction (0.83), hospitalization (0.71), and service utilization (0.71).


CONCLUSIONS
EHR data present both opportunities and challenges for clinical risk prediction. There is room for improvement in designing such studies.
Forest Elephant Crisis in the Congo Basin 

Debate over repealing the ivory trade ban dominates conferences of the Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES). Resolving this controversy requires accurate estimates of elephant population trends and rates of illegal killing. Most African savannah elephant populations are well known; however, the status of forest elephants, perhaps a distinct species, in the vast Congo Basin is unclear. We assessed population status and incidence of poaching from line-transect and reconnaissance surveys conducted on foot in sites throughout the Congo Basin. Results indicate that the abundance and range of forest elephants are threatened from poaching that is most intense close to roads. The probability of elephant presence increased with distance to roads, whereas that of human signs declined. At all distances from roads, the probability of elephant occurrence was always higher inside, compared to outside, protected areas, whereas that of humans was always lower. Inside protected areas, forest elephant density was correlated with the size of remote forest core, but not with size of protected area. Forest elephants must be prioritised in elephant management planning at the continental scale.
A Facilitator to Discover and Compose Services

In this paper, we present our approach of facilitator that allows automatic service composition in distributed systems. We propose a facilitator based on ontologies and knowledge representation that allows clients to discover a service and to get the result of the service execution without direct interactions with their providers. We extend the functionality of the facilitator to be a composition engine and we show how it composes services to satisfy the client’s
Marginal utility of montelukast for persistent asthma.

BACKGROUND
The efficacy of a new pharmacologic agent for asthma, in this instance the leukotriene receptor antagonist montelukast, is determined in controlled trials in research subjects. The utility of a new drug is determined by multiple uncontrollable factors in individual patients.


OBJECTIVE
To assess the utility of montelukast in the management of persistent asthma.


DESIGN
Observational, retrospective.


SETTING
Suburban multispecialty medical clinic.


METHODS
From April 1998, montelukast was prescribed for 110 patients with persistent but controlled asthma, primarily for the corticosteroid-sparing effect. Outcomes after 1 year were determined from audits of medical records and responses to questionnaires.


RESULTS
At least 56% of patients continued receiving montelukast for the entire year. However, compared to those patients who had discontinued montelukast therapy, those who continued receiving it had no difference in the use of inhaled or systemic corticosteroid or inhaled beta(2)-agonist therapy.


CONCLUSION
Montelukast had marginal utility in the management of these adult patients with controlled persistent asthma.
ICT and the Environment in Developing Countries: A Review of Opportunities and Developments

Both developed and developing countries face many environmental challenges, including climate change, improving energy efficiency and waste management, addressing air pollution, water quality and scarcity, and loss of natural habitats and biodiversity. Drawing on the existing literature, this paper presents an overview of how the Internet and the ICT and related research communities can help tackle environmental challenges in developing countries. The review focuses on the role of ICTs in climate change mitigation, mitigating other environmental pressures, and climate change adaptation.
Detectable byzantine agreement secure against faulty majorities

It is well-known that n players, connected only by pairwise secure channels, can achieve Byzantine agreement only if the number t of cheaters satisfies t < n/3, even with respect to computational security. However, for many applications it is sufficient to achieve detectable broadcast. With this primitive, broadcast is only guaranteed when all players are non-faulty ("honest"), but all non-faulty players always reach agreement on whether broadcast was achieved or not. We show that detectable broadcast can be achieved regardless of the number of faulty players (i.e., for all t < n). We give a protocol which is unconditionally secure, as well as two more efficient protocols which are secure with respect to computational assumptions, and the existence of quantum channels, respectively.These protocols allow for secure multi-party computation tolerating any t < n, assuming only pairwise authenticated channels. Moreover, they allow for the setup of public-key infrastructures that are consistent among all participants --- using neither a trusted party nor broadcast channels.Finally, we show that it is not even necessary for players to begin the protocol at the same time step. We give a "detectable Firing Squad" protocol which can be initiated by a single user at any time and such that either all honest players end up with synchronized clocks, or all honest players abort.
XEN WORLDS : XEN AND THE ART OF COMPUTER ENGINEERING EDUCATION

Xen Worlds is being developed to provide a method for performing assignments and lab work in information assurance, operating systems and networking courses that require root access to the individual machines, or the entire network. Currently, there is no existing approach that addresses the root access requirement and the entire life-cycle of an assignment from problem definition, to turn-in of the end product. The Xen Worlds project is aimed at creating a versatile “virtual lab” where an entire network of virtual machines, (a Xen World), can be provided to each student that will allow on-campus and distance education students 24/7 access via SSH, allow students to turn-in a virtual machine or an entire network as the finished product and allow for grading to occur directly on those machines instead of grading a few select artifacts such as configuration files, programs or outputs. To achieve these goals, Xen Worlds builds on several open source products, including utilities for creating virtual network bridges and the Xen virtual machine monitor developed at the University of Cambridge. Combining these building blocks and custom software into a versatile architecture, it has been possible to create an environment that supports multiple backends; provides administrative tools to the students for starting, stopping, resetting, saving and turningin their virtual machines; isolating the Xen Worlds from each other; and allowing the instructor direct access to the virtual machines for grading purposes. The potential of this project was demonstrated by creating a prototype that provided 30 students with their own virtual machine for an entire semester, with all 30 virtual machines being run on a single desktop computer with a Pentium 4 processor and 2GB of RAM. An upper limit of 30 virtual machines being provided was dictated by the amount of physical RAM required by each virtual machine on the desktop computer. The current version of Xen Worlds spreads the virtual machines over many backend computers, allowing up to 240 virtual machines in arbitrary network topologies. Our current goal is to prove Xen Worlds’ potential as an instructional tool, and demonstrate its lower cost compared to commercial solutions such as VMWare. A milestone towards this goal is to provide 1000 virtual machines continuously operating for an entire semester to 200 students in a variety of classes using less than $10,000 in commodity hardware.
Early, transient depletion of plasmacytoid dendritic cells ameliorates autoimmunity in a lupus model

Plasmacytoid dendritic cells (pDCs) have long been implicated in the pathogenesis of lupus. However, this conclusion has been largely based on a correlative link between the copious production of IFN-α/β by pDCs and the IFN-α/β "signature" often seen in human lupus patients. The specific contribution of pDCs to disease in vivo has not been investigated in detail. For this reason, we generated a strain of BXSB lupus-prone mice in which pDCs can be selectively depleted in vivo. Early, transient ablation of pDCs before disease initiation resulted in reduced splenomegaly and lymphadenopathy, impaired expansion and activation of T and B cells, reduced antibodies against nuclear autoantigens and improved kidney pathology. Amelioration of pathology coincided with decreased transcription of IFN-α/β-induced genes in tissues. PDC depletion had an immediate impact on the activation of immune cells, and importantly, the beneficial effects on pathology were sustained even though pDCs later recovered, indicating an early pDC contribution to disease. Together, our findings demonstrate a critical function for pDCs during the IFN-α/β-dependent initiation of autoimmune lupus and point to pDCs as an attractive therapeutic target for the treatment of SLE.
Sustained Responders Have Better Quality of Life and Productivity Compared With Treatment Failures Long After Antiviral Therapy for Hepatitis C

OBJECTIVES:We sought to compare the health status of patients with a sustained response to antiviral therapy for hepatitis C virus (HCV) infection with that of treatment failures, using health-related quality of life and preference (utility) measures.METHODS:Sustained responders had undetectable HCV viral levels 6 months after antiviral therapy. After antiviral therapy, participants completed, by mail or interview, the hepatitis-specific Medical Outcomes Study Short-Form 36-Item Health Survey (SF-36), the Health Utilities Index Mark 2/3 (HUI2/3), and time trade-off (TTO) for current health. The respondents provided information on demographics, history of substance abuse, comorbidities, and health history. Detailed clinical information was obtained by chart review. The respondents also indicated whether they missed work, volunteer opportunities, or household activities during the previous 3 months because of hepatitis C infection or its treatment.RESULTS:A total of 235 patients (133 responders and 102 treatment failures) completed questionnaires at an average of 3.7 years after the end of treatment. Treatment failures had significantly lower scores on the eight SF-36 domains (P<0.01), lower scores on the hepatitis-specific domains (P<0.0001), and lower physical (42.5 vs. 49.2) and mental (40.5 vs. 46.1) component summary scores (P<0.01). HUI3 (0.57 vs. 0.70), HUI2 (0.74 vs. 0.80), SF-6D (0.65 vs. 0.71), and TTO (0.84 vs. 0.89) were lower for treatment failures (P<0.05). The regression-adjusted difference in HUI3, SF-6D, physical summary score, and mental summary score was 0.08 (P=0.04), 0.05 (P=0.004), 5.22 (P=0.001), and 5.73 (P<0.0001), respectively. Differences in the HUI2 and TTO scores were not significant after adjustment for demographic and clinical variables. Treatment failures were more likely to have missed work, volunteer opportunities, or household activities in the previous 3 months because of hepatitis C infection or its treatment (44 vs. 9%, P<0.001).CONCLUSIONS:Patients with a sustained response to antiviral therapy for chronic HCV infection have better quality of life than treatment failures do. Our study validates the benefits associated with the sustained response to antiviral therapy in a real-world clinic population and shows that these benefits are maintained over the long term.
Total quality management (TQM) strategy and organisational characteristics: Evidence from a recent WTO member

This paper presents a comparative study on the relationship between implementing total quality management (TQM) and organisational characteristics (size, type of industry, type of ownership, and degree of innovation) in a newly industrialised country in South East Asia. Vietnam has become the 150th member of the World Trade Organisation (WTO) since January 2007, and this is the first empirical study to examine TQM practices in Vietnam. Analysis through Structural Equation Modelling, t-test and MANOVA of survey data from 222 manufacturing and service companies produced three major findings. First, this study supports previous research findings that TQM can be considered as set of practices. Second, industries in Vietnam have deployed certain TQM practices (customer focus and top management commitment) at much higher levels than others, namely information and analysis system, education and training, employee empowerment, and process management. Finally, MANOVA shows a clear difference in TQM practices by company size, industry type, and degree of innovation. Large companies had higher implementation levels across almost all practices except for teamwork and open organisation when compared to smalland medium-sized companies. TQM practices were statistically more significant in manufacturing companies compared to service companies, and firms having a higher degree of innovation also showed higher levels of TQM practice implementation. In particular, the low deployment of TQM practices in service industries, where TQM has been considered as orderqualifier, highlights the challenges for Vietnam’s service industries that pursue TQM to successfully compete in the global marketplace.
44Sc-PSMA-617 for radiotheragnostics in tandem with 177Lu-PSMA-617—preclinical investigations in comparison with 68Ga-PSMA-11 and 68Ga-PSMA-617

BACKGROUND
The targeting of the prostate-specific membrane antigen (PSMA) is of particular interest for radiotheragnostic purposes of prostate cancer. Radiolabeled PSMA-617, a 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid (DOTA)-functionalized PSMA ligand, revealed favorable kinetics with high tumor uptake, enabling its successful application for PET imaging (68Ga) and radionuclide therapy (177Lu) in the clinics. In this study, PSMA-617 was labeled with cyclotron-produced 44Sc (T 1/2 = 4.04 h) and investigated preclinically for its use as a diagnostic match to 177Lu-PSMA-617.


RESULTS
44Sc was produced at the research cyclotron at PSI by irradiation of enriched 44Ca targets, followed by chromatographic separation. 44Sc-PSMA-617 was prepared under standard labeling conditions at elevated temperature resulting in a radiochemical purity of >97% at a specific activity of up to 10 MBq/nmol. 44Sc-PSMA-617 was evaluated in vitro and compared to the 177Lu- and 68Ga-labeled match, as well as 68Ga-PSMA-11 using PSMA-positive PC-3 PIP and PSMA-negative PC-3 flu prostate cancer cells. In these experiments it revealed similar in vitro properties to that of 177Lu- and 68Ga-labeled PSMA-617. Moreover, 44Sc-PSMA-617 bound specifically to PSMA-expressing PC-3 PIP tumor cells, while unspecific binding to PC-3 flu cells was not observed. The radioligands were investigated with regard to their in vivo properties in PC-3 PIP/flu tumor-bearing mice. 44Sc-PSMA-617 showed high tumor uptake and a fast renal excretion. The overall tissue distribution of 44Sc-PSMA-617 resembled that of 177Lu-PSMA-617 most closely, while the 68Ga-labeled ligands, in particular 68Ga-PSMA-11, showed different distribution kinetics. 44Sc-PSMA-617 enabled distinct visualization of PC-3 PIP tumor xenografts shortly after injection, with increasing tumor-to-background contrast over time while unspecific uptake in the PC-3 flu tumors was not observed.


CONCLUSIONS
The in vitro characteristics and in vivo kinetics of 44Sc-PSMA-617 were more similar to 177Lu-PSMA-617 than to 68Ga-PSMA-617 and 68Ga-PSMA-11. Due to the almost four-fold longer half-life of 44Sc as compared to 68Ga, a centralized production of 44Sc-PSMA-617 and transport to satellite PET centers would be feasible. These features make 44Sc-PSMA-617 particularly appealing for clinical application.
Wetland hydrologic class change from prior to European settlement to present on the Des Moines Lobe, Iowa

It has been hypothesized that wetland restoration policies have favored the restoration of the wettest classes of wetlands on the Des Moines Lobe of the prairie pothole region. To test this hypothesis we compared pre-drainage wetland distributions based on soils data and National Wetland Inventory (NWI) estimates of contemporary wetland distributions on the Des Moines Lobe. Based on the NWI data, the Des Moines Lobe today has only 3–4% of the wetland area that it had prior to the onset of drainage. On the basis of their soils, pre-drainage wetlands were predominantly temporarily flooded to saturated wetlands (84%), with only about 6% of the wetlands with water regimes classified as semi-permanently to permanently flooded. Depending on the interpretation of wetland modifiers on NWI maps, wetlands classified by the NWI as semi-permanent to permanently flooded make up more than 41% of the wetland area while wetlands with temporarily flooded to saturated water regimes account for 45–58% of the Lobe’s wetland area. The water regimes of contemporary wetlands when compared to their historic regimes suggest that many of today’s wetlands have different water regimes than they did prior to the onset of drainage. Because of the regional lowering of the groundwater table, many of today’s wetlands have drier water regimes, but some have wetter water regimes because they receive drainage tile inputs. Our results indicate that restoration has favored the wettest classes of wetlands and that temporarily to saturated wetland classes have not been restored in proportion to their relative abundance in the pre-drainage landscape.
Price dynamics of vertically differentiated information markets

We e@ore the price dynamicsof a verticallyMkmntiated marketin which two or more sellers compete to providean informationgood orserviceto a populationof lmyers.Each sellerofh-s the good or serviceat a iixed levd of “quality”, and attempts to set its price in sud a way that it mtities its om profit. Five dii%rentsellerpricingstrategies, rangingwidelyfrom onesthat requireperfectknowledgeand unlimitedcomputationalpowerto onesthat requireverylittle lmowledgeor computationalcapability,are employedin two d.ifkmntbuyer populations, and the resulting collective dynamics are studied using a comb-mationof analysis and simulation. In a population of quality-sensitivebuyers, all pricing strategieslead to a ptice eqpilibriutnpredictedby a game-theoreticanalysis. However,in a population of price-sensitivebuyers,most pricingstrategieslead to large-amplitudecyclicalprice wars. The circumstancesunderwhichcyclicalpricewarsoccurcanbe explainedin terms of the topology of an underlying’>rofit landscape” [1].
Social behavior and brand devotion among iPhone innovators

Convergence of communication technologies and innovative product features are expanding the markets for technological products and services. Prior literature on technology acceptance and use has focused on utilitarian belief factors as predictors of rational adoption decisions and subsequent user behavior. This presupposes that consumers’ intentions to use technology are based on functional or utilitarian needs. Using netnographic evidence on iPhone usage, this study suggests that innovative consumers adopt and use new technology for not just utilitarian but also for experiential outcomes. The study presents an interpretive analysis of the consumption behavior of very early iPhone users. Apple introduced iPhone as a revolutionary mobile handset offering integrated features and converged services—a handheld computercum-phone with a touch-screen web browser, a music player, an organizer, a note-taker, and a camera. This revolutionary product opened up new possibilities to meld functional tasks, hedonism, and social signaling. The study suggests that even utilitarian users have hedonic and social factors present in their consumption patterns. © 2010 Elsevier Ltd. All rights reserved.