LLukas22/scidocs huggingface dataset:
Hip disability and osteoarthritis outcome score (HOOS) – validity and responsiveness in total hip replacement

BACKGROUND
The aim of the study was to evaluate if physical functions usually associated with a younger population were of importance for an older population, and to construct an outcome measure for hip osteoarthritis with improved responsiveness compared to the Western Ontario McMaster osteoarthritis score (WOMAC LK 3.0).


METHODS
A 40 item questionnaire (hip disability and osteoarthritis outcome score, HOOS) was constructed to assess patient-relevant outcomes in five separate subscales (pain, symptoms, activity of daily living, sport and recreation function and hip related quality of life). The HOOS contains all WOMAC LK 3.0 questions in unchanged form. The HOOS was distributed to 90 patients with primary hip osteoarthritis (mean age 71.5, range 49-85, 41 females) assigned for total hip replacement for osteoarthritis preoperatively and at six months follow-up.


RESULTS
The HOOS met set criteria of validity and responsiveness. It was more responsive than WOMAC regarding the subscales pain (SRM 2.11 vs. 1.83) and other symptoms (SRM 1.83 vs. 1.28). The responsiveness (SRM) for the two added subscales sport and recreation and quality of life were 1.29 and 1.65, respectively. Patients <or= 66 years of age (range 49-66) reported higher responsiveness in all five subscales than patients >66 years of age (range 67-85) (Pain SRM 2.60 vs. 1.97, other symptoms SRM 3.0 vs. 1.60, activity of daily living SRM 2.51 vs. 1.52, sport and recreation function SRM 1.53 vs. 1.21 and hip related quality of life SRM 1.95 vs. 1.57).


CONCLUSION
The HOOS 2.0 appears to be useful for the evaluation of patient-relevant outcome after THR and is more responsive than the WOMAC LK 3.0. The added subscales sport and recreation function and hip related quality of life were highly responsive for this group of patients, with the responsiveness being highest for those younger than 66.
An Empirical Analysis of Traceability in the Monero Blockchain

Monero is a privacy-centric cryptocurrency that allows users to obscure their transactions by including chaff coins, called “mixins,” along with the actual coins they spend. In this paper, we empirically evaluate two weaknesses in Monero’s mixin sampling strategy. First, about 62% of transaction inputs with one or more mixins are vulnerable to “chain-reaction” analysis — that is, the real input can be deduced by elimination. Second, Monero mixins are sampled in such a way that they can be easily distinguished from the real coins by their age distribution; in short, the real input is usually the “newest” input. We estimate that this heuristic can be used to guess the real input with 80% accuracy over all transactions with 1 or more mixins. Next, we turn to the Monero ecosystem and study the importance of mining pools and the former anonymous marketplace AlphaBay on the transaction volume. We find that after removing mining pool activity, there remains a large amount of potentially privacy-sensitive transactions that are affected by these weaknesses. We propose and evaluate two countermeasures that can improve the privacy of future transactions. DOI 10.1515/popets-2018-0025 Received 2017-11-30; revised 2018-03-15; accepted 2018-03-16. *Corresponding Author: Malte Möser: Princeton University, E-mail: mmoeser@princeton.edu Kyle Soska: Carnegie Mellon University, E-mail:
Preferences in distributing scarce goods

Abstract Respondents rated their preference for distributing scarce goods in four studies. Study 1, in which respondents were presented with brief scenarios, and Study 2, in which respondents were presented with single statements about the scarcity, showed that preferences among four different means of distribution (order of application, the market, merit, and random) varied with the nature of the scarcity. There was a tendency for respondents to prefer methods currently employed by society. Study 3 compared the preferences for the market system versus regulation of respondents brought up in a market or a regulated (communist) economy, and Study 4 compared preferences for New Zealand and German students. The results suggest that preferences are not a simple product of either economic upbringing or current practice. PsycINFO classification : 2239; 3040; 3920
Left ventricular strain and peak systolic velocity: responses to controlled changes in load and contractility, explored in a porcine model

BACKGROUND
Tissue velocity echocardiography is increasingly used to evaluate global and regional cardiac function. Previous studies have suggested that the quantitative measurements obtained during ejection are reliable indices of contractility, though their load-sensitivity has been studied in different settings, but still remains a matter of controversy. We sought to characterize the effects of acute load change (both preload and afterload) and change in inotropic state on peak systolic velocity and strain as a measure of LV contractility.


METHODS
Thirteen anesthetized juvenile pigs were studied, using direct measurement of left ventricular pressure and volume and transthoracic echocardiography. Transient inflation of a vena cava balloon catheter produced controlled load alterations. At least eight consecutive beats in the sequence were analyzed with tissue velocity echocardiography during the load alteration and analyzed for change in peak systolic velocities and strain during same contractile status with a controlled load alteration. Two pharmacological inotropic interventions were also included to generate several myocardial contractile conditions in each animal.


RESULTS
Peak systolic velocities reflected the drug-induced changes in contractility in both radial and longitudinal axis. During the acute load change, the peak systolic velocities remain stable when derived from signal in the longitudinal axis and from the radial axis. The peak systolic velocity parameter demonstrated no strong relation to either load or inotropic intervention, that is, it remained unchanged when load was systematically and progressively varied (peak systolic velocity, longitudinal axis, control group beat 1-5.72 ± 1.36 with beat 8-6.49 ± 1.28 cm/sec, 95% confidence interval), with the single exception of the negative inotropic intervention group where peak systolic velocity decreased a small amount during load reduction (beat 1-3.98 ± 0.92 with beat 8-2.72 ± 0.89 cm/sec). Systolic strain, however, showed a clear degree of load-dependence.


CONCLUSIONS
Peak systolic velocity appears to be load-independent as tested by beat-to-beat load reduction, while peak systolic strain appears to be load-dependent in this model. Peak systolic velocity, in a controlled experimental model where successive beats during load alteration are assessed, has a strong relation to contractility. Peak systolic velocity, but not peak strain rate, is largely independent of load, in this model. More study is needed to confirm this finding in the clinical setting.
Mechanics of Crystalline Nanowires : An Experimental Perspective

A wide variety of crystalline nanowires (NWs) with outstanding mechanical properties have recently emerged. Measuring their mechanical properties and understanding their deformation mechanisms are of important relevance to many of their device applications. On the other hand, such crystalline NWs can provide an unprecedented platform for probing mechanics at the nanoscale. While challenging, the field of experimental mechanics of crystalline nanowires has emerged and seen exciting progress in the past decade. This review summarizes recent advances in this field, focusing on major experimental methods using atomic force microscope (AFM) and electron microscopes and key results on mechanics of crystalline nanowires learned from such experimental studies. Advances in several selected topics are discussed including elasticity, fracture, plasticity, and anelasticity. Finally, this review surveys some applications of crystalline nanowires such as flexible and stretchable electronics, nanocomposites, nanoelectromechanical systems (NEMS), energy harvesting and storage, and strain engineering, where mechanics plays a key role. [DOI: 10.1115/1.4035511]
Evolving Algebras and Partial Evaluation

We describe an automated partial evaluator for evolving algebras implemented at the University of Michigan.
Hydatidosis of slaughtered cattle in Wolaita Sodo Abattoir, southern Ethiopia

The study was carried out from July 2007 to June 2008 in Wolaita Sodo Abattoir to assess the status of hydatidosis in cattle. Routine meat inspection, hydatid cyst count and characterization were conducted. Out of 400 cattle slaughtered in Wolaita Sodo Abattoir 64 (16%) animals were found harboring hydatid cysts. Thorough meat inspection in the abattoir revealed that 74 visceral organ were found harboring one or more hydatid cysts. The infection of the lung, liver, spleen and kidney were found to be 45.94% 45.94%, 6.75% and 1.35% respectively. From the total of 283 hydatid cysts counted 153(54.06%), 17(6.00%), 5(1.76%), 108(38.16%) were found to be small, medium, large and calcified cysts respectively and 170(60.28%), 5(1.76%) and 108(38.16%) were sterile, fertile and calcified cysts respectively. The rate of cyst calcification was higher in the liver than in the lung while fertility rate was higher among the cysts of the lung. Hydatid cyst viability rate of 40% was observed.
International Futurism in Arts and Literature

This publication offers for the first time an inter-disciplinary and comparative perspective on Futurism in a variety of countries and artistic media. 20 scholars discuss how the movement shaped the concept of a cultural avant-garde and how it influenced the development of modernist art and literature around the world.
A new class of meta-pyridine-urea oligomers for selective identification of mercury(II) ions

Abstract A series of new pyridine-urea oligomers were synthesized and tested for their ability to recognize ions in PBS or Ac buffer solution by fluorescence. The results showed that the ability of oligourea urea to selectively recognize Hg 2+ was gradually enhanced with the increase of chain, which was further proved by DFT calculation. The 1:2 stoichiometry was established for the L7 -Hg 2+ complex on the basis of Job's plot. The binding constant ( K B ) and the lowest detection limit for Hg 2+ were also determined. DFT calculations were used to optimize the structures of L2-7 and its Hg 2+ complexes. Highly sensitive and selective probes for the recognition of Hg 2+ based on this report are expected to be developed and used for in vivo detection.
Exploring isovist fields : space and shape in architectural and urban morphology

The space that can be seen from any vantage point is called an isovist and the set of such spaces forms a visual field whose extent defines different isovist fields based on different geometric properties. I suggest that our perceptions of moving within such fields might be related to these geometric properties. I begin with a formal representation of isovists and their fields, introducing simple geometric measures based on distance, area, perimeter, compactness, and convexity. I suggest a feasible computational scheme for measuring such fields, and illustrate how we can visualize their spatial and statistical properties by using maps and frequency distributions. I argue that the classification of fields based on these measures must be a prerequisite to the proper analysis of architectural and urban morphologies. To this end, I present two hypothetical examples based on simple geometries and three real examples based on London's Tate Gallery, Regent Street, and the centre of the English town of Wolverhampton. Although such morphologies can often be understood in terms of basic geometrical elements such as corridors, streets, rooms, and squares, isovist analysis suggests that visual fields have their own form which results from the interaction of geometry and movement. To illustrate how such analysis can be used, I outline methods of partitioning space, covering it with a small number of relatively independent isovists, and perceiving space by recording properties of the isovist fields associated with paths through that space. DOI:10.1068/b2725
Initiation of Antiretroviral Therapy in Early Asymptomatic HIV Infection.

BACKGROUND
Data from randomized trials are lacking on the benefits and risks of initiating antiretroviral therapy in patients with asymptomatic human immunodeficiency virus (HIV) infection who have a CD4+ count of more than 350 cells per cubic millimeter.


METHODS
We randomly assigned HIV-positive adults who had a CD4+ count of more than 500 cells per cubic millimeter to start antiretroviral therapy immediately (immediate-initiation group) or to defer it until the CD4+ count decreased to 350 cells per cubic millimeter or until the development of the acquired immunodeficiency syndrome (AIDS) or another condition that dictated the use of antiretroviral therapy (deferred-initiation group). The primary composite end point was any serious AIDS-related event, serious non-AIDS-related event, or death from any cause.


RESULTS
A total of 4685 patients were followed for a mean of 3.0 years. At study entry, the median HIV viral load was 12,759 copies per milliliter, and the median CD4+ count was 651 cells per cubic millimeter. On May 15, 2015, on the basis of an interim analysis, the data and safety monitoring board determined that the study question had been answered and recommended that patients in the deferred-initiation group be offered antiretroviral therapy. The primary end point occurred in 42 patients in the immediate-initiation group (1.8%; 0.60 events per 100 person-years), as compared with 96 patients in the deferred-initiation group (4.1%; 1.38 events per 100 person-years), for a hazard ratio of 0.43 (95% confidence interval [CI], 0.30 to 0.62; P<0.001). Hazard ratios for serious AIDS-related and serious non-AIDS-related events were 0.28 (95% CI, 0.15 to 0.50; P<0.001) and 0.61 (95% CI, 0.38 to 0.97; P=0.04), respectively. More than two thirds of the primary end points (68%) occurred in patients with a CD4+ count of more than 500 cells per cubic millimeter. The risks of a grade 4 event were similar in the two groups, as were the risks of unscheduled hospital admissions.


CONCLUSIONS
The initiation of antiretroviral therapy in HIV-positive adults with a CD4+ count of more than 500 cells per cubic millimeter provided net benefits over starting such therapy in patients after the CD4+ count had declined to 350 cells per cubic millimeter. (Funded by the National Institute of Allergy and Infectious Diseases and others; START ClinicalTrials.gov number, NCT00867048.).
Suicide pact by mutual simultaneous arm amputation.

BACKGROUND
Dyadic suicide pacts are cases in which two individuals (and very rarely more) agree to die together. These account for fewer than 1% of all completed suicides.


OBJECTIVE
The authors describe two men in a long-term domestic partnership who entered into a suicide pact and, despite utilizing a high-lethality method (simultaneous arm amputation with a power saw), survived.


METHOD
The authors investigated the psychiatric, psychological, and social causes of suicide pacts by delving into the history of these two participants, who displayed a very high degree of suicidal intent. Psychiatric interviews and a family conference call, along with the strong support of one patient's family, were elicited.


RESULTS
The patients, both HIV-positive, showed high levels of depression and hopelessness, as well as social isolation and financial hardship. With the support of his family, one patient was discharged to their care, while the other partner was hospitalized pending reunion with his partner.


DISCUSSION
This case illustrates many of the key, defining features of suicide pacts that are carried out and also highlights the nature of the dependency relationship.
YodaNN: An Architecture for Ultralow Power Binary-Weight CNN Acceleration

Convolutional neural networks (CNNs) have revolutionized the world of computer vision over the last few years, pushing image classification beyond human accuracy. The computational effort of today’s CNNs requires power-hungry parallel processors or GP-GPUs. Recent developments in CNN accelerators for system-on-chip integration have reduced energy consumption significantly. Unfortunately, even these highly optimized devices are above the power envelope imposed by mobile and deeply embedded applications and face hard limitations caused by CNN weight I/O and storage. This prevents the adoption of CNNs in future ultralow power Internet of Things end-nodes for near-sensor analytics. Recent algorithmic and theoretical advancements enable competitive classification accuracy even when limiting CNNs to binary (+1/−1) weights during training. These new findings bring major optimization opportunities in the arithmetic core by removing the need for expensive multiplications, as well as reducing I/O bandwidth and storage. In this paper, we present an accelerator optimized for binary-weight CNNs that achieves 1.5 TOp/s at 1.2 V on a core area of only 1.33 million gate equivalent (MGE) or 1.9 mm 2 and with a power dissipation of 895  $\mu$ W in UMC 65-nm technology at 0.6 V. Our accelerator significantly outperforms the state-of-the-art in terms of energy and area efficiency achieving 61.2 TOp/s/W@0.6 V and 1.1 TOp/s/MGE@1.2 V, respectively.
Adult scoliosis: prevalence, SF-36, and nutritional parameters in an elderly volunteer population.

STUDY DESIGN
A prospective self-assessment analysis and evaluation of nutritional and radiographic parameters in a consecutive series of healthy adult volunteers older than 60 years.


OBJECTIVES
To ascertain the prevalence of adult scoliosis, assess radiographic parameters, and determine if there is a correlation with functional self-assessment in an aged volunteer population.


SUMMARY OF BACKGROUND DATA
There exists little data studying the prevalence of scoliosis in a volunteer aged population, and correlation between deformity and self-assessment parameters.


METHODS
There were 75 subjects in the study. Inclusion criteria were: age > or =60 years, no known history of scoliosis, and no prior spine surgery. Each subject answered a RAND 36-Item Health Survey questionnaire, a full-length anteroposterior standing radiographic assessment of the spine was obtained, and nutritional parameters were analyzed from blood samples. For each subject, radiographic, laboratory, and clinical data were evaluated. The study population was divided into 3 groups based on frontal plane Cobb angulation of the spine. Comparison of the RAND 36-Item Health Surveys data among groups of the volunteer population and with United States population benchmark data (age 65-74 years) was undertaken using an unpaired t test. Any correlation between radiographic, laboratory, and self-assessment data were also investigated.


RESULTS
The mean age of the patients in this study was 70.5 years (range 60-90). Mean Cobb angle was 17 degrees in the frontal plane. In the study group, 68% of subjects met the definition of scoliosis (Cobb angle >10 degrees). No significant correlation was noted among radiographic parameters and visual analog scale scores, albumin, lymphocytes, or transferrin levels in the study group as a whole. Prevalence of scoliosis was not significantly different between males and females (P > 0.03). The scoliosis prevalence rate of 68% found in this study reveals a rate significantly higher than reported in other studies. These findings most likely reflect the targeted selection of an elderly group. Although many patients with adult scoliosis have pain and dysfunction, there appears to be a large group (such as the volunteers in this study) that has no marked physical or social impairment.


CONCLUSIONS
Previous reports note a prevalence of adult scoliosis up to 32%. In this study, results indicate a scoliosis rate of 68% in a healthy adult population, with an average age of 70.5 years. This study found no significant correlations between adult scoliosis and visual analog scale scores or nutritional status in healthy, elderly volunteers.
The Individualized Diet and Exercise Adherence Pilot Trial (IDEA-P) in prostate cancer patients undergoing androgen deprivation therapy: study protocol for a randomized controlled trial

BACKGROUND
Androgen deprivation therapy (ADT) is the foundation of treatment for men with metastatic prostate cancer and is now frequently incorporated into multimodality strategies for the curative treatment of locally advanced prostate cancer. Nevertheless, the catabolic effects of ADT result in meaningful adverse effects on physiological and quality of life outcomes, which may, in turn, increase the risk of functional decline, frailty, cardiovascular disease, and metabolic syndrome. Recent evidence demonstrates that lifestyle intervention promoting change in exercise and dietary behaviors is a promising approach, and may offset, or even reverse, the adverse effects accompanying ADT. Unfortunately, the limited existing studies of the effects of exercise and dietary interventions targeting patients with prostate cancer on ADT are characterized by high attrition rates and poor postintervention maintenance of treatment effects. Consequently, the Individualized Diet and Exercise Adherence Pilot Trial (IDEA-P) is designed to contrast the effects of a lifestyle intervention designed to promote independent self-management of exercise and dietary behavior with those of standard care disease management approach in the treatment of prostate cancer.


METHODS/DESIGN
A total of 40 patients with prostate cancer undergoing ADT will be randomly assigned to lifestyle intervention or standard care. Outcomes of interest in IDEA-P include changes in self-reported and objectively assessed physical function and physical activity, dietary behavior, body composition, muscular strength, and quality of life. Outcomes will be obtained at baseline, 2-month, and 3-month assessments by trial personnel blinded to participants' randomization assignment.


DISCUSSION
Findings from this study will establish the feasibility and preliminary efficacy of an innovative lifestyle intervention designed to promote progressively independent self-regulated exercise and dietary behavior change in the treatment of patients with prostate cancer undergoing ADT.


TRIAL REGISTRATION
ClinicalTrials.gov NCT02050906.