LLukas22/scidocs huggingface dataset:
Real-time efficient FPGA implementation of aes algorithm

An efficient optimized area and speed FPGA implementation for the Advanced Encryption Standard is proposed in this paper. The iterative looping method is adopted with multistage sub-pipelining architecture to achieve a 1.33 Gbps throughput for the AES-128 bit Encryption process. The proposed design operates at 425 MHz with 303 CLB slices on a Xilinx Virtex-5 XC5VLX50 FPGA Device. For real-time hardware evaluation, an end-user Java based application is developed. The software application is linked to the hardware design through the Xilinx MicroBlaze soft processor core.
Nonintrusive appliance load monitoring: Review and outlook

Consumer systems for home energy management can provide significant energy saving. Such systems may be based on nonintrusive appliance load monitoring (NIALM), in which individual appliance power consumption information is disaggregated from single-point measurements. The disaggregation methods constitute the most important part of NIALM systems. This paper reviews the methodology of consumer systems for NIALM in residential buildings.
Evaluation of epoetin supplemented with oral iron in patients with solid malignancies and chronic anemia not receiving anticancer treatment.

OBJECTIVE
To evaluate the effectiveness and improvement in quality of life (QOL) of epoetin alfa administration supplemented with oral iron as a therapeutic regimen for patients with solid malignancies and anemia of chronic disease (ACD), not receiving chemotherapy and/or radiotherapy.


PATIENTS AND METHODS
A total of 100 patients with cancer-related anemia, not subjected to chemotherapy and/or radiotherapy, were randomized to receive for a maximum of 24 weeks either oral iron, equivalent to 200 mg elemental iron once daily, or epoetin alfa 40,000 IU subcutaneously once weekly plus oral iron once daily.


RESULTS
Patients in the epoetin alfa group had, from baseline to study end, a mean increase in hemoglobin (Hb) levels of 2.4 g/dL, whereas in the control group the mean Hb level decreased by 0.1 g/dL, (p<0.001). Improvement in QOL as assessed by the LASA and the FACT-An questionnaire were greater in patients in the epoetin alfa group than in the control group (mean change, LASA-energy level: 30.4 mm vs. 0.4 mm, -daily activities: 31.7 mm vs. 0.4 mm, -overall well-being. 32.4 mm vs. 4.9, FACT-An: 43.3 vs. 13.4, respectively). As for ECOG score, patients in the epoetin alfa group had a mean improvement of 0.16 from baseline to study end (control group: 0.06). Improvement in QOL parameters and in ECOG scores correlated positively with increased hemoglobin levels.


CONCLUSION
Our results suggest that weekly epoetin alfa therapy supplemented with daily oral iron increases Hb levels and improves QOL in patients with solid malignancies and ACD who are not receiving chemotherapy and/or radiotherapy. This regimen offers optimal therapy in this population taking into consideration physician's convenience and patient's compliance.
Online support: Impact on anxiety in women who experience an abnormal screening mammogram.

OBJECTIVES
To determine whether an online support tool can impact anxiety in women experiencing an abnormal mammogram.


MATERIALS AND METHODS
We developed an online support system using the Comprehensive Health Enhancement Support System (CHESS) designed for women experiencing an abnormal mammogram as a model. Our trial randomized 130 of these women to online support (the intervention group) or to a list of five commonly used Internet sites (the comparison group). Surveys assessed anxiety and breast cancer worry, and patient satisfaction at three important clinical time points: when women were notified of their abnormal mammogram, at the time of diagnostic imaging, and at the time of biopsy (if biopsy was recommended).


RESULTS
Study participants in the intervention group showed a significant decrease in anxiety at the time of biopsy compared to the comparison group (p = 0.017). However, there was no significant difference in anxiety between the intervention group and the comparison group at the time of diagnostic work-up. We discontinued assessment of patient satisfaction after finding that many women had substantial difficulty answering the questions that referenced their physician, because they did not understand who their physician was for this process of care.


CONCLUSION
The combination of the inability to identify the physician providing care during the mammography work-up and anxiety effects seen only after an interaction with the breast imaging team may indicate that online support only decreases the anxiety of women in concert with direct interpersonal support from the healthcare team.
The Colombian Novel, 1844–1987

The Colombian Novel, 1844-1987. RAYMOND LESLIE WILLIAMS. Austin: University of Texas Press, 1991. 279 pp. $32.50 (cloth). ISBN 0-292-75542-2.
Modulated model predictive current control for direct matrix converter with fixed switching frequency

Matrix converters have become popular due to their capability for direct ac-ac conversion without a dc-link capacitor. Several modulation methods have been proposed for matrix converters including Space Vector Modulation (SVM), which has been widely used in conjunction with numerous different control approaches as it can ensure sinusoidal input and output currents with unity power factor and fixed switching frequency. Model Predictive Control (MPC) is a control strategy introduced recently for power converters with several benefits like fast transient response and possibility to control multiple variables without cascaded loops; however it produces a variable switching frequency. This paper introduces a new control technique for direct matrix converters that combines the features of the classical MPC and SVM technique into a Modulated Model Predictive Control (M2PC) with fixed switching frequency. Simulation results showing the effectiveness of the method in controlling a direct matrix converter feeding a passive RL load are presented in this paper.
Phase I dose-escalating study of ES-285 given as a three-hour intravenous infusion every three weeks in patients with advanced malignant solid tumors

Background ES-285 (spisulosine) is a novel compound derived from the marine mollusk Spisula polynoma with evidence of preclinical antitumor activity. This phase I clinical trial was designed to identify the maximum tolerated dose (MTD) and the recommended dose for phase II trials (RD), as well as to evaluate the safety profile, pharmacokinetics and preliminary efficacy data of ES-285 in patients with advanced solid tumors. Patients and Methods Sixty-one patients at two medical institutions were treated with a 3-h ES-285 intravenous infusion every 3 weeks. Nine dose levels were evaluated. Results No dose-limiting toxicities (DLTs) were observed during dose escalation from 4 to 128 mg/m2. Six patients had seven DLTs at the three highest dose levels tested: 256 mg/m2 (n = 2), 200 mg/m2 (n = 3) and 160 mg/m2 (n = 1). Grade 3/4 transaminase increases (n = 3), grade 3/4 central nervous system disorders [confusion (n = 2) and ataxia (n = 1)], and grade 3 pyrexia (n = 1) were the dose-limiting toxicities found with this ES-285 administration schedule. Pharmacokinetic analysis showed ES-285 dose linearity, wide distribution and a long half-life. One non-confirmed partial response was observed in a patient with metastatic melanoma treated with ES-285 128 mg/m2, and 18 patients showed stable disease at different dose levels, lasting longer than 3 months in six patients. Conclusion Dose level VIII (200 mg/m2) was considered the MTD, and dose level IX (160 mg/m2) was defined as the RD. Limited antitumor activity was observed.
The ZX-calculus is complete for stabilizer quantum mechanics

The ZX-calculus is a graphical calculus for reasoning about quantum systems and processes. It is known to be universal for pure state qubit quantum mechanics, meaning any pure state, unitary operation and post-selected pure projective measurement can be expressed in the ZX-calculus. The calculus is also sound, i.e. any equality that can be derived graphically can also be derived using matrix mechanics. Here, we show that the ZX-calculus is complete for pure qubit stabilizer quantum mechanics, meaning any equality that can be derived using matrices can also be derived pictorially. The proof relies on bringing diagrams into a normal form based on graph states and local Clifford operations.
The Personality Belief Questionnaire-Short Form: Development and Preliminary Findings

Two studies are reported which document the development and psychometric properties of an abbreviated version of the Personality Belief Questionnaire (PBQ). In the first study, the seven PBQ items with the highest item–total correlations with each PBQ scale were used to construct experimental scales. These scales showed good internal consistency and discriminated five personality disorders as predicted. Items from the experimental scales were then incorporated into a new measure—the PBQ Short Form (SF)—which was administered to an independent sample of psychiatric patients. The PBQ-SF scales showed good reliability and correlated significantly with depression, anxiety, dysfunctional attitudes, neuroticism, self-esteem, and psychosocial functioning. Findings suggest that the overall elevation of a PBQ-SF profile is influenced by a general distress factor, whereas variability of PBQ-SF scales within a profile reveals disorder-specific effects. It is concluded that the PBQ-SF is a practical alternative as a measure of personality disorder beliefs.
Phase I study of weekly DN-101, a new formulation of calcitriol, in patients with cancer

DN-101 is a new, high-dose, oral formulation of calcitriol under investigation for the treatment of cancer. We sought to evaluate the tolerability and pharmacokinetics (PK) of weekly doses of DN-101 in patients with advanced cancer. Patients who completed a previously reported single dose escalation study of DN-101 [Beer et al. (2005) Clin Cancer Res 11:7794–7799] were eligible for this continuation weekly dosing study. Cohorts of 3–10 patients were treated at doses of 15, 30, 45, 60, and 75 μg calcitriol. Once 45 μg was established as the maximum tolerated dose (MTD), this cohort was expanded to include 18 patients. Dose limiting toxicity (DLT) was defined as ≥grade 2 hypercalcemia or ≥grade 3 persistent treatment-related toxicities. Thirty-seven patients were recruited. DLT of transient reversible grade 2 hypercalcemia (serum calcium of 11.6–12.5 mg/dL) occurred in two of six patients treated with 60 μg of DN-101. No DLT was observed in the 18 patients who received DN-101 weekly at 45 μg. Overall, DN-101 was well tolerated. The most frequent adverse events were fatigue (27%), hypercalcemia (19%, including five grade 1, two grade 2, and no grade 3 or 4 events), and grade 1 nausea (16%). PK parameters following repeat dosing were comparable to those for the initial dose (n = 4). The MTD for weekly DN-101 was established as 45 μg. The DLTs observed were two episodes of rapidly reversible grade 2 hypercalcemia in two of the six patients treated at 60 μg weekly. Repeat doses of DN-101 at 45 μg weekly are well tolerated and this dose is suitable for studies of weekly DN-101 in cancer patients.
Developing an IoT Smart City framework

In this paper, we discuss key findings, technological challenges and socioeconomic opportunities in Smart City era. Most of the conclusions were gathered during SmartSantander project, an EU project that is developing a city-scale testbed for IoT and Future Internet experimentation, providing an integrated framework for implementing Smart City services.
Status of Wetlands in Bangalore and its Conservation aspects

Wetlands are among the most important ecosystems, that are valuable as sources, sinks, and transformers of a multitude of chemical, biological, and genetic materials. The interaction of man with wetlands is the first humanizing system initiated in the process of evolution and development of many civilizations. Societies have enjoyed an ancient association with wetlands and have learned to obtain multiple benefitsnatural resources, amenities and environmental services. In recent years, the wetland values are overlooked resulting due to population pressures and unplanned development. This has threatened the very existence of these vital ecosystems. In order to stem the tide of destruction, especially for wetlands located in urban setup suitable guidelines to assess the ecological integrity and effective monitoring programs are required. This includes collecting sufficient information on the various functions, components and attributes of wetlands to reduce the ongoing ecological imbalance. In view of this there is a need to periodically monitor these systems. Water quality assessment of seven waterbodies located at various places in Bangalore urban district has been monitored for a period of twelve months, based on the findings of the study suitable restoration measures are suggested. Ecological restoration and ecosystem management is an essential component of any habitat conservation. The management of wetlands has become important because these ecosystems are still being reclaimed or encroached for agricultural activities, aquaculture, for sewage disposal, etc. Hence for developing a site specific management plan for wetlands it is imperative to gather baseline information so as to understand the structure and functions of a wetland. In the recent past the wetlands of Bangalore are drawing considerable attention and concern because of their importance realised. The present paper attempts to identify some of the major threats, wetland face today and make suitable suggestions to draw the attention of to wetland biologists, conservationists, planners and policy makers.
Involving consumers in designing, conducting, and interpreting randomised controlled trials: questionnaire survey.

OBJECTIVE
To assess the extent to which consumers are involved in the work of clinical trial coordinating centres in the United Kingdom and the nature of consumers' involvement in randomised trials coordinated by these centres.


DESIGN
National surveys using structured questionnaires with some open ended sections.


SETTING
103 clinical trial coordinating centres in the United Kingdom identified through a database assembled in 1997 by the NHS clinical trials adviser.


PARTICIPANTS
Named contacts at 62 coordinating centres and investigators in 60 trials that were identified as involving consumers.


MAIN OUTCOME MEASURES
Number of coordinating centres and number of trials in which consumers were involved and the nature of consumers' involvement.


RESULTS
Of the 62 eligible centres, 23 reported that consumers had already been involved in their work, and most respondents were positive about this involvement. 17 centres planned to involve consumers. 15 centres had no plans to involve consumers, but only four of these considered such involvement irrelevant. Responses from investigators about the 48 individual trials were mostly positive, with respondents commenting that input from consumers had helped refine research questions, improve the quality of patient information, and make the trial more relevant to the needs of patients.


CONCLUSIONS
Consumer involvement in the design and conduct of controlled trials seems to be growing and seems to be welcomed by most researchers. Such involvement seems likely to improve the relevance to consumers of the questions addressed and the results obtained in controlled trials.
Introducing the HOPE (Hypospadias Objective Penile Evaluation)-score: a validation study of an objective scoring system for evaluating cosmetic appearance in hypospadias patients.

OBJECTIVE
To determine the reliability and internal validity of the Hypospadias Objective Penile Evaluation (HOPE)-score, a newly developed scoring system assessing the cosmetic outcome in hypospadias.


PATIENTS AND METHODS
The HOPE scoring system incorporates all surgically-correctable items: position of meatus, shape of meatus, shape of glans, shape of penile skin and penile axis. Objectivity was established with standardized photographs, anonymously coded patients, independent assessment by a panel, standards for a "normal" penile appearance, reference pictures and assessment of the degree of abnormality. A panel of 13 pediatric urologists completed 2 questionnaires, each consisting of 45 series of photographs, at an interval of at least 1 week. The inter-observer reliability, intra-observer reliability and internal validity were analyzed.


RESULTS
The correlation coefficients for the HOPE-score were as follows: intra-observer reliability 0.817, inter-observer reliability 0.790, "non-parametric" internal validity 0.849 and "parametric" internal validity 0.842. These values reflect good reproducibility, sufficient agreement among observers and a valid measurement of differences and similarities in cosmetic appearance.


CONCLUSIONS
The HOPE-score is the first scoring system that fulfills the criteria of a valid measurement tool: objectivity, reliability and validity. These favorable properties support its use as an objective outcome measure of the cosmetic result after hypospadias surgery.
The multiple meanings of open government data: Understanding different stakeholders and their perspectives

The Multiple Meanings of Open Government Data: Understanding Different Stakeholders and Their Perspectives Felipe Gonzalez-Zapata & Richard Heeks Centre for Development Informatics, University of Manchester, Manchester, M13 9PL, UK Corresponding author: Prof. Richard Heeks, Centre for Development Informatics, IDPM, SEED, University of Manchester, Manchester, M13 9PL, UK, +44-161-275-2870 richard.heeks@manchester.ac.uk
Point defect of titanium sesquioxide Ti2O3 as the application of next generation Li-ion batteries

Abstract By means of first-principles calculation, we explore the vacancy mechanism of titanium sesquioxide (Ti 2 O 3 ) and further investigate the influence of vacancy on the electronic properties of Ti 2 O 3 . Two vacancy models are considered. We find that Ti 2 O 3 prefers to form oxygen vacancy (O -va ) in comparison to Ti vacancy (Ti -va ) because the removed oxygen atom improves the localized hybridization between Ti and O. The low concentration of vacancies is more thermodynamic stability than that of high concentration of vacancies. In comparison to titanium dioxide (TiO 2 ), Ti 2 O 3 exhibits the metallic behavior due to the band overlap between the conduction band and the valence band. Importantly, we find that those vacancies enhance the electronic transport of Ti 2 O 3 because the removed atom promotes the band overlaps at the Fermi level ( E F ).
A two-phase heuristic for the scheduling of independent tasks on computational grids

The sensitivity analysis of a cellular genetic algorithm with local search is used to design a new and simpler heuristic for the problem of scheduling independent tasks. The proposed heuristic improves the previously known Min-Min heuristic. Moreover, it provides schedules of similar quality to the reference cellular genetic algorithm in a significantly reduced runtime. This heuristic is evaluated across twelve different classes of scheduling instances.
A Review of Big Data Security and Privacy Protection Technology

To study and solve the issues of big data security and privacy protection is the key to promote the healthy development of big data. In this paper, a 3D big data security and privacy protection model based on life cycle, security goal and user role is presented, and the security challenges and security goals of big data are analyzed from different aspects. The feasible technology and its application in big data security and privacy protection are expounded and analyzed, and the in-depth research direction of big data security and privacy protection is discussed and summarized.
Simple real-time QRS detector with the MaMeMi filter

Detection of QRS complexes in ECG signals is required to determine heart rate, and it is an important step in the study of cardiac disorders. ECG signals are usually affected by noise of low and high frequency. To improve the accuracy of QRS detectors several methods have been proposed to filter out the noise and detect the characteristic pattern of QRS complex. Most of the existing methods are at a disadvantage from relatively high computational complexity or high resource needs making them less optimized for its eywords: onlinear filters iomedical signal processing RS detection eal-time systems mbedded software implementation on portable embedded systems, wearable devices or ultra-low power chips. We present a new method to detect the QRS signal in a simple way with minimal computational cost and resource needs using a novel non-linear filter. © 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Challenges in Umbilical Cord Blood Stem Cell Banking for Stem Cell Reviews and Reports

Twenty years has passed since the first report of a successful cord blood transplant was reported in 1989 in a child with Fanconi’s anemia. During these 20 years, the cord blood field has had dramatic growth, with over 400,000 cord blood units donated and stored worldwide for unrelated use. Approximately, 14,000 unrelated cord blood transplants have been performed to date for patients with hematologic malignancies and bone marrow disorders, and who do not have matched family or unrelated donors. In contrast, about 900,000 cord blood units have been stored privately for personal use, with about 100 autologous transplants performed. Twenty years ago, due to the low cell dose, cord blood transplants were only performed in children. Today, with the use of better banking techniques, reduced intensity transplants, and double cord blood transplantation, the majority of cord blood transplants are being performed in adults. In this chapter, we review the scientific basis for cord blood transplantation, and outcome data in both pediatric and adult transplantation. We will then focus on the recent concerns regarding private and public cord blood banking. Finally, we discuss the future of cord blood transplantation, and the exciting work beginning outside of oncology.
Description of shape information for 2-D and 3-D objects

The description of the spatial characteristics of twoand three-dimensional objects, in the framework of MPEG-7, is considered. The shape of an object is one of its fundamental properties, and this paper describes an e$cient way to represent the coarse shape, scale and composition properties of an object. This representation is invariant to resolution, translation and rotation, and may be used for both two-dimensional (2-D) and three-dimensional (3-D) objects. This coarse shape descriptor will be included in the eXperimentation Model (XM) of MPEG-7. Applications of such a description to search object databases, in particular the CAESAR anthropometric database are discussed. ( 2000 Elsevier Science B.V. All rights reserved.