LLukas22/scidocs huggingface dataset:
Hybrid I&C Grounding in PFBR

Nuclear Power plants require well established grounding scheme towards personnel safety and smooth control of the plant. Combination of Single & Multi point grounding with Faraday cage configuration is followed in Prototype Fast Breeder Reactor (PFBR). This paper explains the scheme.
The A 1 chieve study : a 60000-person , global , prospective , observational study of basal , mealtime , and biphasic insulin analogs in daily clinical practice

Siddharth N. Shaha, León Litwakb, Jihad Haddadc, Praful N. Chakkarward,*, Issam Hajjaji e a Department of Endocrinology, S.L. Raheja Hospital, Mumbai, India b Hospital Italiano de Buenos Aires, Buenos Aires, Argentina c Endocrinology Section, Bader Medical Complex, Amman, Jordan d Novo Nordisk Region International Operations A/S, Zurich, Switzerland e National Centre for Diabetes & Endocrinology, Tripoli, Libya
Peripheral blood mono-nuclear cells implantation in patients with peripheral arterial disease: a pilot study for clinical and biochemical outcome of neoangiogenesis

BACKGROUND
Substantial progresses in the management of peripheral arterial disease (PAD) have been made in the past two decades. Progress in the understanding of the endothelial-platelet interaction during health and disease state has resulted in better antiplatelet drugs that can prevent platelet aggregation, activation and thrombosis during angioplasty and stenting. A role in physiological and pathological angiogenesis in adults has been recently shown in bone marrow-derived circulating endothelial progenitors (BM-DCEPs) identified in the peripheral blood. These findings have paved the way for the development of therapeutic neovascularization techniques using endothelial progenitors.


METHODS
This pilot study includes five patients, aged 60 to 75, with a history of claudication and recruited from September 2010 to February 2011 at the A.O.U. Federico II of Naples.PBMNCs have been implanted three times in the limb with the worst ABI value in all the patients included in the study.The clinical follow up was performed during the subsequent 12 months from the beginning of the treatment.


RESULTS
In four patients there was a regression of ulcerative lesions.One patient's condition improved after the first implantation but later did not respond to the further treatments.All patients achieved a pain relief as judged by the numeric pain scale. Pain relief remained satisfactory in three patients for one year. Pain gradually returned to the pre-treatment level in two patients.All patients referred an ameliorating in their quality of life expressed even by an improvement in claudication free walking distance.These improvements are reflected also by intra-arterial digital subtraction angiography (IADSA) that shows an improvement of arterial vascularization.


CONCLUSIONS
The data from this study suggest an efficacy of BM-DCEPs implantation in terms of improvement of the vascularization and quality of life in patients affected by Peripheral Arterial Disease. Nevertheless a double-blind placebo-controlled study is needed to confirm our findings.
Perindopril improves six minute walking distance in older patients with left ventricular systolic dysfunction: a randomised double blind placebo controlled trial.

OBJECTIVE
To evaluate the effects of the angiotensin converting enzyme inhibitor perindopril on six minute walking distance and quality of life in very old patients with left ventricular systolic dysfunction.


DESIGN
Prospective, double blind placebo controlled trial.


SETTING
Medicine for the elderly day hospital.


PATIENTS
66 patients (average age 81) with left ventricular systolic dysfunction identified by echocardiography.


INTERVENTIONS
10 weeks of treatment with titrated doses of perindopril or placebo.


MAIN OUTCOME MEASURES
Six minute walking distance 10 weeks following treatment, quality of life measurements including the Minnesota living with heart failure questionnaire and the 36 item short form health survey.


RESULTS
In patients with left ventricular systolic dysfunction, six minute walking distance was significantly increased in the treatment group (37.1 m) compared with the placebo group (-0.3 m, p < 0.001). The medication was well tolerated and there were no significant adverse events.


CONCLUSIONS
Six minute walking distance is improved considerably by treatment with perindopril in older patients with heart failure caused by left ventricular systolic dysfunction.
Biplanar proximal phalanx closing wedge osteotomy for hallux rigidus.

BACKGROUND
Many procedures have been described for surgical treatment of symptomatic hallux rigidus. Dorsal cheilectomy of the metatarsophalangeal joint combined with a dorsal-based closing wedge osteotomy of the proximal phalanx (i.e., Moberg procedure) has been described as an effective procedure. For patients with hallux rigidus and clinically significant hallux valgus interphalangeus, the authors previously described a dorsal cheilectomy combined with a biplanar closing wedge osteotomy of the proximal phalanx, combining a Moberg osteotomy with an Akin osteotomy. The purpose of this study was to describe the clinical results of this procedure.


METHODS
This article is a retrospective review of prospectively gathered data that reports the clinical and radiographic results of dorsal cheilectomy combined with a biplanar oblique closing wedge proximal phalanx osteotomy (i.e., Moberg-Akin procedure) for patients with symptomatic hallux rigidus and hallux valgus interphalangeus. Consecutive patients were followed and evaluated for clinical and radiographic healing, satisfaction, and ultimate need for additional procedure(s). Thirty-five feet in 34 patients underwent the procedure.


RESULTS
All osteotomies healed. At an average of 22.5 months of follow-up, 90% of patients reported good or excellent results, with pain relief, improved function, and fewer shoe wear limitations following this procedure. Hallux valgus and hallux interphalangeal angles were radiographically improved. Other than one patient who requested hardware removal, no patients required additional surgical procedures.


CONCLUSIONS
Dorsal cheilectomy combined with a Moberg-Akin procedure was an effective and durable procedure with minimal morbidity in patients with hallux rigidus combined with hallux valgus interphalangeus.
Revision anterior cruciate ligament reconstruction: an update

With the rising number of anterior cruciate ligament (ACL) reconstructions performed, revision ACL reconstruction is increasingly common nowadays. A broad variety of primary and revision ACL reconstruction techniques have been described in the literature. Recurrent instability after primary ACL surgery is often due to non-anatomical ACL graft reconstruction and altered biomechanics. Anatomical reconstruction must be the primary goal of this challenging revision procedure. Recently, revision ACL reconstruction has been described using double bundle hamstring graft. Successful revision ACL reconstruction requires an exact understanding of the causes of failure and technical or diagnostic errors. The purpose of this article is to review the causes of failure, preoperative evaluation, graft selection and types of fixation, tunnel placement, various types of surgical techniques and clinical outcome of revision ACL reconstruction.
A de-identifier for medical discharge summaries

OBJECTIVE
Clinical records contain significant medical information that can be useful to researchers in various disciplines. However, these records also contain personal health information (PHI) whose presence limits the use of the records outside of hospitals. The goal of de-identification is to remove all PHI from clinical records. This is a challenging task because many records contain foreign and misspelled PHI; they also contain PHI that are ambiguous with non-PHI. These complications are compounded by the linguistic characteristics of clinical records. For example, medical discharge summaries, which are studied in this paper, are characterized by fragmented, incomplete utterances and domain-specific language; they cannot be fully processed by tools designed for lay language.


METHODS AND RESULTS
In this paper, we show that we can de-identify medical discharge summaries using a de-identifier, Stat De-id, based on support vector machines and local context (F-measure=97% on PHI). Our representation of local context aids de-identification even when PHI include out-of-vocabulary words and even when PHI are ambiguous with non-PHI within the same corpus. Comparison of Stat De-id with a rule-based approach shows that local context contributes more to de-identification than dictionaries combined with hand-tailored heuristics (F-measure=85%). Comparison with two well-known named entity recognition (NER) systems, SNoW (F-measure=94%) and IdentiFinder (F-measure=36%), on five representative corpora show that when the language of documents is fragmented, a system with a relatively thorough representation of local context can be a more effective de-identifier than systems that combine (relatively simpler) local context with global context. Comparison with a Conditional Random Field De-identifier (CRFD), which utilizes global context in addition to the local context of Stat De-id, confirms this finding (F-measure=88%) and establishes that strengthening the representation of local context may be more beneficial for de-identification than complementing local with global context.
Recurrence After Marginal Excision for Atypical Lipomatous Tumors Versus Lipomas of the Extremities.

This study reviewed the medical records of 90 patients with lipomas (47 patients) and atypical lipomatous tumors (ALT)/well-differentiated liposarcomas (WDL) (43 patients) of the extremities treated from 2006 to 2012. All patients had preoperative biopsy and postoperative histologic analysis of the tumors; surgical margins were marginal in all cases. Histologic sections of the tissue blocks from the excised specimens were re-reviewed for all patients; a consensus with postoperative histologic analysis was confirmed. Molecular chromosome analysis was performed on fluorescence in situ hybridization in tissue sections from the tissue blocks in all cases for the purpose of this study; a ratio greater than 2 was considered to represent murine double-minute 2 (MDM2) amplification consistent with a diagnosis of ALT/WDL. Mean follow-up was 52 months (range, 14-96 months). Local recurrence and metastasis rates and the relationship of patient age and sex with tumor size and location were evaluated. None of the patients with lipomas experienced local recurrence compared with 6 patients (13.9%) with ALT/WDL who experienced local recurrence within a mean of 48 months (range, 33-96 months); this difference was statistically significant. None of the patients in either group experienced metastasis prior to the study period. Local recurrence did not correlate statistically with patient age or sex, or with tumor size or location. [Orthopedics. 2016; 39(4):e610-e614.].
Validation of self-reported diabetes in a representative sample of São Paulo city

OBJECTIVE To validate the self-reported diabetes mellitus in adults and older adults living in the city of São Paulo, Brazil. METHODS We have used data of 569 subjects (284 adults and 285 older adults), participants of the population-based cross-sectional study Inquérito de Saúde do Município de São Paulo (Health Survey of São Paulo). Fasting glucose ≥ 7.0 mmol/L (126 mg/dL) and/or use of drugs (oral hypoglycemic and/or insulin) defined the diagnosis of diabetes mellitus. We have validated the self-reported diabetes mellitus by calculating the sensitivity, specificity, positive predictive values, and negative predictive values. We have used Poisson regression with robust variance to verify the factors associated with the sensitivity of the self-reported datum. For all analyses, we have considered the sample design of the study. RESULTS The sensitivity of self-reported diabetes mellitus was 63.8% (95%CI 49.2-76.3), specificity was 99.7% (95%CI 99.1-99.9), positive predictive value was 95.5% (95%CI 84.4-98.8), and negative predictive value was 96.9% (95%CI 94.9-98.2). The correct reporting of diabetes mellitus was more prevalent among older adults (PR = 2.0; 95%CI 1.2-3.5) than among adults. CONCLUSIONS The use of the datum of self-reported diabetes mellitus is valid, especially among older adults living in the city of São Paulo. The results highlight the need to track diabetes mellitus in asymptomatic subjects who have one or more risk factors for it, mainly in the adult population of this city.
Static validation of security protocols

Chiara Bodei a, Mikael Buchholtz b, Pierpaolo Degano a, Flemming Nielson b and Hanne Riis Nielson b a Dipartimento di Informatica, Università di Pisa, Via F. Buonarroti 2, I-56127 Pisa, Italy E-mail: {chiara,degano}@di.unipi.it b Informatics and Mathematical Modelling, Technical University of Denmark, Richard Petersens Plads bldg 321, DK-2800 Kongens Lyngby, Denmark E-mail: {mib,nielson,riis}@imm.dtu.dk
Study of Attenuation and Dispersion Through the Skin in Intrabody Communications Systems

Intrabody communication (IBC) is a technique that uses the human body as a transmission medium for electrical signals to connect wireless body sensors, e.g., in biomedical monitoring systems. In this paper, we propose a simple, but accurate propagation model through the skin based on a distributed-parameter circuit in order to obtain general expressions that could assist in the design of IBC systems. In addition, the model is based on the major electrophysiological properties of the skin. We have found the attenuation and dispersion parameters and they have been successfully compared with several published results, thus showing the tuning capability of the model to different experimental conditions. Finally, we have evaluated different digital modulation schemes in order to assess the tradeoffs between symbol rate, bit error rate, and distance between electrodes of the skin communication channel.
Modern Multivariate Statistical Techniques

CHAPTER 3 Page 46, line –15: (K × J)-matrix. Page 47, Equation (3.5): −EF should be −EF . Page 49, line –6: R should be <. Page 53, line –7: “see Exercise 3.4” is not relevant here. Page 53, Equation (3.43): Last term on rhs should be ∂yJ ∂xK . Page 60, Equation (3.98): σ should be σ. Page 61, line 8: (3.106) should be (3.105). Pages 61, 62, Equations (3.109), (3.110), and (3.111): The identity matrices have different dimensions — In the top row of each matrix, the identity matrix has dimension r and in the bottom row it has dimension s. Page 62, line 1: “r-vector” should be “(r + s)-vector.” Page 62, Equation (3.111): ΣXY should be ΣY X . Page 64, Equation (3.127): |Σ| should be |Σ|. Page 62, Equation (3.133): I(2.2) should be I(2,2). Page 65, line 8 (2nd line of property 2): Wr should be Wp. Page 65, property 4: Restate as follows. Let X = (X1, · · · ,Xn) , where Xi ∼ Nr(0,Σ), i = 1, 2, . . . , n, are independently and identically distributed (iid). Let A be a symmetric (n×n)-matrix with ν = rank(A), and let a be a fixed r-vector. Let y = Xa. Then, X AX ∼ Wr(ν,Σ) iff yAy ∼ σ aχ 2 ν , where σ 2 a = a Σa. Page 66, Equation (3.143): last term on rhs, +n should be −n2 . Page 67, line 3: Should read tr(TT ) = ∑r i=1 t 2 ii + ∑ i>j t 2 ij . Page 67, line –6: Should read “idempotent with rank n − 1.” Page 67, line –3: bX should be X b. Page 67, Equation (3.148): n should be n − 1.
cuDNN: Efficient Primitives for Deep Learning

We present a library that provides optimized implementations for deep learning primitives. Deep learning workloads are computationally intensive, and optimizing the kernels of deep learning workloads is difficult and time-consuming. As parallel architectures evolve, kernels must be reoptimized for new processors, which makes maintaining codebases difficult over time. Similar issues have long been addressed in the HPC community by libraries such as the Basic Linear Algebra Subroutines (BLAS) [2]. However, there is no analogous library for deep learning. Without such a library, researchers implementing deep learning workloads on parallel processors must create and optimize their own implementations of the main computational kernels, and this work must be repeated as new parallel processors emerge. To address this problem, we have created a library similar in intent to BLAS, with optimized routines for deep learning workloads. Our implementation contains routines for GPUs, and similarly to the BLAS library, could be implemented for other platforms. The library is easy to integrate into existing frameworks, and provides optimized performance and memory usage. For example, integrating cuDNN into Caffe, a popular framework for convolutional networks, improves performance by 36% on a standard model while also reducing memory consumption.
Chocolate intake increases urinary excretion of polyphenol-derived phenolic acids in healthy human subjects.

BACKGROUND
Proanthocyanidins, the most abundant polyphenols in chocolate, are not depolymerized in the stomach and reach the small intestine intact, where they are hardly absorbed because of their high molecular weight. In vitro and in vivo studies using pure compounds as substrates suggest that proanthocyanidins and the related catechin monomers may be degraded into more bioavailable low-molecular-weight phenolic acids by the microflora in the colon.


OBJECTIVE
The aim of the study was to estimate the amounts of phenolic acids formed by the microflora and excreted in the urine of human subjects after consumption of polyphenol-rich chocolate.


DESIGN
After consumption of a polyphenol-free diet for 2 d and a subsequent overnight fast, 11 healthy subjects (7 men and 4 women) consumed 80 g chocolate containing 439 mg proanthocyanidins and 147 mg catechin monomers. All urine was collected during the 24 h before chocolate consumption and at 3, 6, 9, 24, and 48 h after chocolate consumption. Aromatic acids were identified in urine by gas chromatography-mass spectrometry and were quantified by HPLC-electrospray ionization tandem mass spectrometry.


RESULTS
Chocolate intake increased the urinary excretion of the 6 following phenolic acids: m-hydroxyphenylpropionic acid, ferulic acid, 3,4-dihydroxyphenylacetic acid, m-hydroxyphenylacetic acid, vanillic acid, and m-hydroxybenzoic acid.


CONCLUSION
The antioxidant and biological effects of chocolate may be explained not solely by the established absorption of catechin monomers but also by the absorption of microbial phenolic acid metabolites.
TET2 mutations improve the new European LeukemiaNet risk classification of acute myeloid leukemia: a Cancer and Leukemia Group B study.

PURPOSE
To determine the frequency of TET2 mutations, their associations with clinical and molecular characteristics and outcome, and the associated gene- and microRNA-expression signatures in patients with primary cytogenetically normal acute myeloid leukemia (CN-AML).


PATIENTS AND METHODS
Four-hundred twenty-seven patients with CN-AML were analyzed for TET2 mutations by polymerase chain reaction and direct sequencing and for established prognostic gene mutations. Gene- and microRNA-expression profiles were derived using microarrays.


RESULTS
TET2 mutations, found in 23% of patients, were associated with older age (P < .001) and higher pretreatment WBC (P = .04) compared with wild-type TET2 (TET2-wt). In the European LeukemiaNet (ELN) favorable-risk group (patients with CN-AML who have mutated CEBPA and/or mutated NPM1 without FLT3 internal tandem duplication [FLT3-ITD]), TET2-mutated patients had shorter event-free survival (EFS; P < .001) because of a lower complete remission (CR) rate (P = .007), and shorter disease-free survival (DFS; P = .003), and also had shorter overall survival (P = .001) compared with TET2-wt patients. TET2 mutations were not associated with outcomes in the ELN intermediate-I-risk group (CN-AML with wild-type CEBPA and wild-type NPM1 and/or FLT3-ITD). In multivariable models, TET2 mutations were associated with shorter EFS (P = .004), lower CR rate (P = .03), and shorter DFS (P = .05) only among favorable-risk CN-AML patients. We identified a TET2 mutation-associated gene-expression signature in favorable-risk but not in intermediate-I-risk patients and found distinct mutation-associated microRNA signatures in both ELN groups.


CONCLUSION
TET2 mutations improve the ELN molecular-risk classification in primary CN-AML because of their adverse prognostic impact in an otherwise favorable-risk patient subset. Our data suggest that these patients may be candidates for alternative therapies.
Subjective sleep quality, objective sleep characteristics, insomnia symptom severity, and daytime sleepiness in women aged 50 and older with nonmetastatic breast cancer.

PURPOSE/OBJECTIVES
To examine subjective sleep quality in women aged 50 and older as predicted by cancer status, age, number of comorbidities, and symptoms of depressed mood; and to describe objective sleep characteristics, insomnia symptom severity, and daytime sleepiness.


DESIGN
Descriptive.


SETTING
Urban university and private oncology clinics in the southern United States.


SAMPLE
32 women with and 35 without nonmetastatic breast cancer, aged 50-90 years (X=64.9, SD=4.67).


METHODS
Two telephone interviews, the Pittsburgh Sleep Quality Index, Profile of Mood States, three days of home actigraphy, Insomnia Severity Index, Epworth Sleepiness Scale, and medical records review.


MAIN RESEARCH VARIABLES
Subjective quality of sleep; secondary objectives were sleep characteristics, insomnia symptoms, and daytime sleepiness.


FINDINGS
Poor subjective sleep quality was predicted by depressed mood (p<0.00005). All mean objective sleep characteristics were similar for the breast cancer and comparison groups. Nocturnal awakenings were excessive (9.2 versus 7.3). Mean sleep onset latency was longer for the breast cancer group than for the comparison group (34.8 versus 15.6 minutes). Mean insomnia severity scores for the breast cancer group indicated subthreshold insomnia symptoms, and no clinically significant insomnia for the comparison group (8.9 versus 6.4). Mean daytime sleepiness scores were normal for both groups (7 versus 6).


CONCLUSIONS
Subjective sleep quality was predicted by depressed mood only. Sleep in the breast cancer group was characterized by poor sleep quality, frequent nocturnal awakenings, and insomnia symptoms.


IMPLICATIONS FOR NURSING
Screening and monitoring in women aged 50 and older with breast cancer may help promote early sleep intervention; however, additional collaborative research regarding the underlying causes of sleep disruption is needed.
Knowledge management and competitive advantage : The interaction effect of market orientation

This paper examines the relationship between knowledge management and competitive advantage, in a developing country, Uganda; with a particular focus on the interacting influence of market orientation. A sample size of 718 organizations was selected from a population of 11,153 organizations using a simple random sampling method. Primary data were collected through a self-administered questionnaire. Descriptive and inferential statistics were used in the analysis. The findings show that there is a positive correlation between knowledge management and competitive advantage; which relationship is greatly enhanced by the interaction impact of market orientation. When market-based knowledge is appropriately responded to, it augments the competitiveness of the organization. In addition, this is an indication that competitive advantage is best achieved through a combination of knowledge-based resources. Based on the results, a number of managerial implications were identified such as: creating a balance between knowledge management and market orientation. Among the advanced recommendations is the need for the development of proactive market-oriented organization.