LLukas22/scidocs huggingface dataset:
Francaise d ' Oncologie Pediatrique LMB 89 protocol : highly effective multiagent chemotherapy tailored to the tumor burden and initial response in 561 unselected children with B-cell lymphomas and L 3 leukemia

Citation for published version (APA): Patte, C., Auperin, A., Michon, J., Leverger, G., Frappaz, D., Lutz, P., ... Terrier-Lacombe, M-J. (2001). The Societe Francaise d'Oncologie Pediatrique LMB89 protocol: highly effective multiagent chemotherapy tailored to the tumor burden and initial response in 561 unselected children with B-cell lymphomas and L3 leukemia. Blood, 97(11), 3370-3379. DOI: 10.1182/blood.V97.11.3370
Writing the woman artist : essays on poetics, politics, and portraiture

Writing the Woman Artist is a collection of essays that explore the ways women writers portray women painters, sculptors, writers, and performers.
The influence of technology anxiety on consumer use and experiences with self-service technologies

The explosion of new technologies is revolutionizing the retail environment. Yet, not all consumers choose to use the new technologies nor do all consumers see these changes as improvements. In this research, we explore usage patterns and benefits of using self-service technologies (SSTs) based on a sample of 823 consumers. We also assess the influence of individual characteristics, specifically technology anxiety (TA) and particular demographics, on SST usage patterns and satisfaction levels. The findings indicate that respondents with higher levels of TA use fewer SSTs and that TA is a better, more consistent predictor of SST usage than are demographic variables. In addition, TA was found to influence overall levels of satisfaction, intentions to use the SST again and the likelihood of participating in positive word-ofmouth for those consumers who had an initially satisfying experience. D 2002 Elsevier Science Inc. All rights reserved.
Does Size Matter? Authorship Attribution, Small Samples, Big Problem

The aim of this study is to find a minimal size of text samples for authorship attribution that would provide stable results independent of random noise. A few controlled tests for different sample lengths, languages and genres are discussed and compared. Although I focus on Delta methodology, the results are valid for many other multidimensional methods relying on word frequencies and "nearest neighbor" classifications.
Screening for Psychosocial Risk in Dutch Families of a Child With Cancer: Reliability, Validity, and Usability of the Psychosocial Assessment Tool.

OBJECTIVE
The Psychosocial Assessment Tool (PAT) was developed to screen for psychosocial risk in families of a child diagnosed with cancer. The current study is the first describing the cross-cultural adaptation, reliability, validity, and usability of the PAT in an European country (Dutch translation).


METHODS
A total of 117 families (response rate 59%) of newly diagnosed children with cancer completed the PAT2.0 and validation measures.


RESULTS
Acceptable reliability was obtained for the PAT total score (α = .72) and majority of subscales (0.50-0.82). Two subscales showed inadequate internal consistency (Social Support α = .19; Family Beliefs α = .20). Validity and usability were adequate. Of the families, 66% scored low (Universal), 29% medium (Targeted), and 5% high (Clinical) risk.


CONCLUSIONS
This study confirms the cross-cultural applicability, reliability, and validity of the PAT total score. Reliability left room for improvement on subscale level. Future research should indicate whether the PAT can be used to provide cost-effective care.
Experimental peri-implant tissue breakdown around different dental implant surfaces: clinical and radiographic evaluation in dogs.

PURPOSE
Tissue reactions to 4 different implant surfaces were evaluated in regard to the development and progression of ligature-induced peri-implantitis.


MATERIALS AND METHODS
In 6 male mongrel dogs, a total of 36 dental implants with different surfaces (9 titanium plasma-sprayed, 9 hydroxyapatite-coated, 9 acid-etched, and 9 commercially pure titanium) were placed 3 months after mandibular premolar extraction. After 3 months with optimal plaque control, abutment connection was performed. Forty-five days later, cotton ligatures were placed around the implants to induce peri-implantitis. At baseline and 20, 40, and 60 days after placement, the presence of plaque, peri-implant mucosal redness, bleeding on probing, probing depth, clinical attachment loss, mobility, vertical bone loss, and horizontal bone loss were assessed.


RESULTS
The results did not show significant differences among the surfaces for any parameter during the study (P > .05). All surfaces were equally susceptible to ligature-induced peri-implantitis over time (P < .001). Correlation analysis revealed a statistically significant relationship between width of keratinized tissue and vertical bone loss (r2 = 0.81; P = .014) and between mobility and vertical bone loss (r2 = 0.66; P = .04), both for the titanium plasma-sprayed surface.


DISCUSSION AND CONCLUSIONS
The present data suggest that all surfaces were equally susceptible to experimental peri-implantitis after a 60-day period.
Large-scale production of foot-and-mouth disease virus (serotype Asia1) VLP vaccine in Escherichia coli and protection potency evaluation in cattle

BACKGROUND
Foot-and-mouth disease (FMD) is an acute, highly contagious disease that infects cloven-hoofed animals. Vaccination is an effective means of preventing and controlling FMD. Compared to conventional inactivated FMDV vaccines, the format of FMDV virus-like particles (VLPs) as a non-replicating particulate vaccine candidate is a promising alternative.


RESULTS
In this study, we have developed a co-expression system in E. coli, which drove the expression of FMDV capsid proteins (VP0, VP1, and VP3) in tandem by a single plasmid. The co-expressed FMDV capsid proteins (VP0, VP1, and VP3) were produced in large scale by fermentation at 10 L scale and the chromatographic purified capsid proteins were auto-assembled as VLPs in vitro. Cattle vaccinated with a single dose of the subunit vaccine, comprising in vitro assembled FMDV VLP and adjuvant, developed FMDV-specific antibody response (ELISA antibodies and neutralizing antibodies) with the persistent period of 6 months. Moreover, cattle vaccinated with the subunit vaccine showed the high protection potency with the 50 % bovine protective dose (PD50) reaching 11.75 PD50 per dose.


CONCLUSIONS
Our data strongly suggest that in vitro assembled recombinant FMDV VLPs produced from E. coli could function as a potent FMDV vaccine candidate against FMDV Asia1 infection. Furthermore, the robust protein expression and purification approaches described here could lead to the development of industrial level large-scale production of E. coli-based VLPs against FMDV infections with different serotypes.
A Pedagogical Note on the Open Economy IS-LM Model

This note will be of particular value to teachers of the intermediate macroeconomic theory course. It identifies a serious limitation in the diagrammatic presentation of the IS-LM model when the increasingly difficult-to-ignore influence of international capital flows on the balance of payments is recognized.
Methodology for robot mapping and navigation in assisted living environments

Robust navigation in living environments demands high requirements on the control system of a robot. Due to typically narrow passages between obstacles, precise navigation is required. To achieve accuracy in navigation, detailed representation of the environment around the robot needs to be developed. Robust and precise mapping of the environment helps in overcoming the dynamics in the living environment like movement of furniture and human beings. Prompt recovery from unreachable paths while navigating is also an essential component of the living environment robots. This paper describes a behaviour-based navigation system in assisted living environments. The navigation system uses a grid map created from data obtained from laser scanner and ultrasonic sensors mounted on a small sized robot, ARTOS. ARTOS is specially designed for indoor living environments able to navigate through narrow corridors and closely placed furniture in the living environment.
Midterm Outcome of Coronary Artery Bypass Grafting in Young Patients: A Multicenter Italian Study.

BACKGROUND
Myocardial revascularization in young patients should be durable enough to avoid new cardiovascular events or repeated revascularization procedures. The aim of this study was to evaluate the late outcomes of patients less than 50 years of age undergoing coronary artery bypass grafting (CABG) in comparison with older patients.


METHODS
This study was a survival analysis of a pooled multicenter prospective cohort of patients who underwent CABG.


RESULTS
Five percent of patients (572 of 11,087) were less than 50 years of age. The prevalence of female sex, pulmonary disease, diabetes, stroke, and extracardiac arteriopathy was lower compared with that in older patients. Left ventricular function was more well preserved in patients less than 50 years of age, but the prevalence of recent myocardial infarction and the need for emergency surgical intervention was significantly higher in young patients. Multiple propensity score-adjusted analysis showed that patients aged less than 50 years had a significantly lower risk of mortality, even when compared with the 50- to 59-year stratum. In the propensity score-matched population (544 pairs), patients less than 50 years of age had significantly better 7-year outcomes compared with patients aged 50 years or more: survival (95.6% versus 81.1%; p < 0.0001), freedom from stroke (97.4% versus 95.3%; p = 0.009), freedom from major adverse cardiac and cerebrovascular events (MACCE) (76.6% versus 63.9%; p = 0.002). Similar freedom from myocardial infarction (90.1% versus 90.1%; p = 0.68) and repeated revascularization (87.1% versus 87.2%; p = 0.65) was observed in patients less than 50 years of age and those older than 50 years.


CONCLUSIONS
Patients less than 50 years of age undergoing CABG have an excellent outcome compared with elderly patients. These data indicate that despite its premature onset, coronary artery disease in young patients does not have a more aggressive course than that in older patients.
Photonic Crystals: Molding the Flow of Light (second Edition)

John D. Joannopoulos, Steven G. Johnson, Joshua N. Winn & Robert D. Meade: Photonic Crystals: Molding the Flow of Light (Second Edition) is published by Princeton University Press and copyrighted, © 2008, by Princeton University Press. All rights reserved. No part of this book may be reproduced in any form by any electronic or mechanical means (including photocopying, recording, or information storage and retrieval) without permission in writing from the publisher, except for reading and browsing via the World Wide Web. Users are not permitted to mount this file on any network servers.
Outcomes at 2 years of age after repeat doses of antenatal corticosteroids.

BACKGROUND
We previously reported the results of a randomized, controlled trial showing that repeat doses of antenatal corticosteroids reduced the risk of respiratory distress syndrome and serious neonatal morbidity. However, data have not been available regarding longer-term effects of this treatment.


METHODS
Women who had received an initial course of corticosteroid treatment 7 or more days previously were randomly assigned to receive an intramuscular injection of corticosteroid (11.4 mg of betamethasone) or saline placebo; the dose was repeated weekly if the mother was still considered to be at risk for preterm delivery and the duration of gestation was less than 32 weeks. We assessed survival free of major neurosensory disability and body size of the children at 2 years of corrected age.


RESULTS
Of the 1085 children who were alive at 2 years of age, 1047 (96.5%) were seen for assessment (521 exposed to repeat-corticosteroid treatment and 526 exposed to placebo). The rate of survival free of major disability was similar in the repeat-corticosteroid and placebo groups (84.4% and 81.0%, respectively; adjusted relative risk, 1.04, 95% confidence interval, 0.98 to 1.10; adjusted P=0.20). There were no significant differences between the groups in body size, blood pressure, use of health services, respiratory morbidity, or child behavior scores, although children exposed to repeat doses of corticosteroids were more likely than those exposed to placebo to warrant assessment for attention problems (P=0.04).


CONCLUSIONS
Administration of repeat doses of antenatal corticosteroids reduces neonatal morbidity without changing either survival free of major neurosensory disability or body size at 2 years of age. (Current Controlled Trials number, ISRCTN48656428 [controlled-trials.com].).
Efficacy and safety of ABT-335 (fenofibric acid) in combination with rosuvastatin in patients with mixed dyslipidemia: a phase 3 study.

OBJECTIVE
To evaluate a new formulation of fenofibric acid (ABT-335) co-administered with 2 doses of rosuvastatin in patients with mixed dyslipidemia.


METHODS
In a phase 3, multicenter, randomized, double-blind, active-controlled study, a total of 1445 patients with LDL-C>or=130 mg/dL, TG>or=150 mg/dL, and HDL-C<40 mg/dL (<50 mg/dL for women) were randomized to either ABT-335 (135 mg), rosuvastatin (10, 20, or 40 mg), or ABT-335+rosuvastatin 10 or 20 mg, and treated for 12 weeks. The primary efficacy comparisons were mean percent change in HDL-C and TG (ABT-335+rosuvastatin vs. corresponding dose of rosuvastatin), and LDL-C (ABT-335+rosuvastatin vs. ABT-335).


RESULTS
Combination therapy with ABT-335+rosuvastatin 10 mg resulted in significantly (p<0.001) greater improvements in HDL-C (20.3% vs. 8.5%) and TG (-47.1% vs. -24.4%) compared to rosuvastatin 10 mg; and LDL-C (-37.2% vs. -6.5%) compared to ABT-335. Similarly, significantly (p<0.001) greater improvements were observed with ABT-335+rosuvastatin 20 mg in HDL-C (19.0% vs. 10.3%) and TG (-42.9% vs. -25.6%) compared to rosuvastatin 20 mg; and LDL-C (-38.8% vs. -6.5%) compared to ABT-335 monotherapy. Greater improvements in multiple secondary endpoints were noted with combination therapy compared to prespecified monotherapies. Both combination therapy doses were generally well tolerated, with a safety profile consistent with ABT-335 and rosuvastatin monotherapies. No rhabdomyolysis or unexpected hepatic, renal, or muscle safety signals were identified.


CONCLUSION
In patients with mixed dyslipidemia, combination therapy with ABT-335+rosuvastatin resulted in more effective control of multiple lipid parameters than either monotherapy alone, with a safety profile similar to both monotherapies. This combination may be an appropriate therapeutic option to treat mixed dyslipidemia.
The Impact of Emotional Intelligence on Nursing: An Overview

In this paper we focus on the role that Emotional Intelligence has on nursing. We pay attention to both students and professionals and the role emotional intelligence has on emotional self-concept and burnout. Our studies with nursing students yield positive relations between the Clarity and Emotional Repair components of Perceived Emotional Intelligence and all scales of the self-concept scale. On the other hand, nursing professionals that have clear feelings about their emotions and situations that occur, and are capable of dealing with those emotions, have lower levels of stress in their work. Also, those nurses who show a high ability to curtail their negative emotional states and prolong positive emotional states show higher levels of overall health than those individuals who have trouble regulating their emotions. Our results imply that the emotional and cognitive dimensions have to be taken into account in future training programs for nursing professionals and students
The SEP4 Gene of Arabidopsis thaliana Functions in Floral Organ and Meristem Identity

The ABC model of flower organ identity is widely recognized as providing a framework for understanding the specification of flower organs in diverse plant species. Recent studies in Arabidopsis thaliana have shown that three closely related MADS-box genes, SEPALLATA1 (SEP1), SEP2 and SEP3, are required to specify petals, stamens, and carpels because these organs are converted into sepals in sep1 sep2 sep3 triple mutants. Additional studies indicate that the SEP proteins form multimeric complexes with the products of the B and C organ identity genes. Here, we characterize the SEP4 gene, which shares extensive sequence similarity to and an overlapping expression pattern with the other SEP genes. Although sep4 single mutants display a phenotype similar to that of wild-type plants, we find that floral organs are converted into leaf-like organs in sep1 sep2 sep3 sep4 quadruple mutants, indicating the involvement of all four SEP genes in the development of sepals. We also find that SEP4 contributes to the development of petals, stamens, and carpels in addition to sepals and that it plays an important role in meristem identity. These and other data demonstrate that the SEP genes play central roles in flower meristem identity and organ identity.
Ca.U.M.Ha. robotic hand (Cassino-Underactuated-Multifinger-Hand)

The mechatronic design of Ca.U.M.Ha. (Cassino-Underactuated-Multifinger-Hand) and the analysis of some experimental grasping tests of a built prototype are presented in this paper. Ca.U.M.Ha. robotic hand shows an anthropomorphic design since provided of four articulated fingers and a simplified contrasting thumb, which are all joined to a rigid palm. The main characteristics of Ca.U.M.Ha. are the underactuation of each finger mechanism with three phalanxes and the common operation through PWM (pulse- width-modulation) modulated pneumatic digital valves of the four articulated fingers with pneumatic actuation. The actuation force control of Ca.U.M.Ha. is obtained by controlling the pressure in the pushing chambers of the pneumatic actuators.
Compressed sensing and Cholesky decomposition on FPGAs and GPUs

Compressed sensing (CS) is a revolutionary signal acquisition theory, enabling signal acquisition at a rate that is below the Nyquist sampling rate. However, CS signal reconstruction algorithms are computationally expensive. One of the key computation steps in CS algorithms is to iteratively compute a Cholesky decomposition. Modern application acceleration devices, such as FPGAs and GPUs, can accelerate Cholesky decomposition and CS signal reconstruction computation. This paper presents high performance parallel Cholesky decomposition algorithms for GPU and FPGA implementation. For GPUs, an optimized Cholesky decomposition algorithm is developed with high parallelism, reduced data copying, and improved memory access. For FPGAs, a dedicated pipelined hardware architecture for Cholesky decomposition is designed. Only one pipelined triangular linear equation solver is needed for solving Cholesky decomposition and Cholesky decomposition-based linear equation systems. Moreover, CS signal reconstruction algorithms are accelerated on GPUs and FPGAs for fast signal recovery based on our iterative Cholesky decomposition. Results show that the proposed Cholesky decomposition on FPGAs and GPUs are much faster than LAPACK and MAGMA for small matrices. For accelerating CS signal reconstruction algorithms, our FPGA implementation can achieve around 15 speedup and our GPU implementation can achieve about a 38 speedup compared with the CPU using LAPACK and the hybrid CPU/GPU system with MAGMA. 2012 Elsevier B.V. All rights reserved.
Neurologic involvement in scleroderma: a systematic review.

OBJECTIVES
To perform a systematic review of neurologic involvement in Systemic sclerosis (SSc) and Localized Scleroderma (LS), describing clinical features, neuroimaging, and treatment.


METHODS
We performed a literature search in PubMed using the following MeSH terms, scleroderma, systemic sclerosis, localized scleroderma, localized scleroderma "en coup de sabre", Parry-Romberg syndrome, cognitive impairment, memory, seizures, epilepsy, headache, depression, anxiety, mood disorders, Center for Epidemiologic Studies Depression (CES-D), SF-36, Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Patient Health Questionnaire-9 (PHQ-9), neuropsychiatric, psychosis, neurologic involvement, neuropathy, peripheral nerves, cranial nerves, carpal tunnel syndrome, ulnar entrapment, tarsal tunnel syndrome, mononeuropathy, polyneuropathy, radiculopathy, myelopathy, autonomic nervous system, nervous system, electroencephalography (EEG), electromyography (EMG), magnetic resonance imaging (MRI), and magnetic resonance angiography (MRA). Patients with other connective tissue disease knowingly responsible for nervous system involvement were excluded from the analyses.


RESULTS
A total of 182 case reports/studies addressing SSc and 50 referring to LS were identified. SSc patients totalized 9506, while data on 224 LS patients were available. In LS, seizures (41.58%) and headache (18.81%) predominated. Nonetheless, descriptions of varied cranial nerve involvement and hemiparesis were made. Central nervous system involvement in SSc was characterized by headache (23.73%), seizures (13.56%) and cognitive impairment (8.47%). Depression and anxiety were frequently observed (73.15% and 23.95%, respectively). Myopathy (51.8%), trigeminal neuropathy (16.52%), peripheral sensorimotor polyneuropathy (14.25%), and carpal tunnel syndrome (6.56%) were the most frequent peripheral nervous system involvement in SSc. Autonomic neuropathy involving cardiovascular and gastrointestinal systems was regularly described. Treatment of nervous system involvement, on the other hand, varied in a case-to-case basis. However, corticosteroids and cyclophosphamide were usually prescribed in severe cases.


CONCLUSIONS
Previously considered a rare event, nervous system involvement in scleroderma has been increasingly recognized. Seizures and headache are the most reported features in LS en coup de sabre, while peripheral and autonomic nervous systems involvement predominate in SSc. Moreover, recently, reports have frequently documented white matter lesions in asymptomatic SSc patients, suggesting smaller branches and perforating arteries involvement.
Georeferencing Wikipedia pages using language models from Flickr

The task of assigning geographic coordinates to web resources has recently gained in popularity. In particular, several recent initiatives have focused on the use of language models for georeferencing Flickr photos, with promising results. Such techniques, however, require the availability of large numbers of spatially grounded training data. They are therefore not directly applicable for georeferencing other types of resources, such as Wikipedia pages. As an alternative, in this paper we explore the idea of using language models that are trained on Flickr photos for finding the coordinates of Wikipedia pages. Our experimental results show that the resulting method is able to outperform popular methods that are based on gazetteer look-up.