LLukas22/scidocs huggingface dataset:
Preventing traffic accidents with in-vehicle decision support systems - The impact of accident hotspot warnings on driver behaviour

Despite continuous investment in road and vehicle safety, as well as improvements in technology standards, the total amount of road traffic accidents has been increasing over the last decades. Consequently, identifying ways of effectively reducing the frequency and severity of traffic accidents is of utmost importance. In light of the depicted challenge, latest studies provide promising evidence that in-vehicle decision support systems (DSSs) can have significant positive effects on driving behaviour and collision avoidance. Going beyond existing research, we developed a comprehensive in-vehicle DSS, which provides accident hotspot warnings to drivers based on location analytics applied to a national historical accident dataset, composed of over 266,000 accidents. As such, we depict the design and field evaluation of an in-vehicle DSS, bridging the gap between real world location analytics and in-vehicle warnings. The system was tested in a country-wide field test of 57 professional drivers, with over 170,000km driven during a four-week period, where vehicle data were gathered via a connected car prototype system. Ultimately, we demonstrate that in-vehicle warnings of accident hotspots have a significant improvement on driver behaviour over time. In addition, we provide first evidence that an individual’s personality plays a key role in the effectiveness of in-vehicle DSSs. However, in contrast to existing lab experiments with very promising results, we were unable to find an immediate effect on driver behaviour. Hence, we see a strong need for further field experiments with high resolution car data to confirm that in-vehicle DSSs can deliver in diverse field situations. © 2017 Elsevier B.V. All rights reserved.
Wnt/β-Catenin Signaling Induces Proliferation, Survival and Interleukin-8 in Human Endothelial Cells

Wnts are secreted signaling proteins able to control diverse biological processes such as cell differentiation and proliferation. Many Wnts act through a canonical, β-catenin signaling pathway. Here, we report that Wnt receptors and transcriptional effectors are expressed in primary human endothelial cells and that Wnt/β-catenin signaling promotes angiogenesis. Human umbilical vein and microvascular endothelial cells express Wnt receptors, Frizzled-4, -5, -6, and β-catenin-associated transcription factors, Tcf-1, -3, -4 and Lef-1. In endothelial cells, ectopic expression of Wnt-1 stabilized cytosolic β-catenin, demonstrating activation of the Wnt/β-catenin canonical signaling pathway. Expression of Wnt-1 or a stabilized and active form of β-catenin, β-cateninS37A, promoted endothelial cell proliferation. Proliferation induced by Wnt/β-catenin signaling was optimal in the presence of bFGF. β-cateninS37A expression in endothelial cells promoted survival after growth factor deprivation. Using matrigel assays, Wnt-1 or β-cateninS37A expression promoted the formation of capillary-like networks. To help define the effectors of Wnt angiogenic function, microarray analysis was used to compare endothelial cells expressing Wnt-1 to control cells. Interleukin-8, a known angiogenic factor, was identified as a transcriptional target of Wnt/β-catenin signaling in endothelial cells. Expression of either Wnt-1 or β-cateninS37A induced Interleukin-8 transcripts and secreted protein. We thus conclude that Wnt/β-catenin signaling promotes angiogenesis possibly via the induction of known angiogenic regulators such as Interleukin-8.
IEEE 1451-1-6: Providing common network services over MQTT

IEEE 1451 has been around for almost 20 years and in that time it has seen many changes in the world of smart sensors. One of the most distinct paradigms to arise was the Internet-of-Things and with it, the popularity of light-weight and simple to implement communication protocols. One of these protocols in particular, MQ Telemetry Transport has become synonymous with large cloud service providers such as Amazon Web Services, IBM Watson, and Microsoft Azure, along with countless other services. While MQTT had be traditionally used in controlled networks within server centers, the simplicity of the protocol has caused it to be utilized on the open internet. Now being called the language of the IoT, it seems obvious that any standard that is aiming to bring a common network service layer to the IoT architecture should be able to utilize MQTT. This paper proposes potential methodologies to extend the Common Architectures and Network services found in the IEEE 1451 Family of Standard into applications which utilize MQTT.
Macular carotenoid supplementation in subjects with atypical spatial profiles of macular pigment.

This study was designed to investigate the impact of macular carotenoid supplementation on the spatial profile of macular pigment (MP) in subjects where the profile does not exhibit the typical central peak (i.e. peaked MP at foveal epicentre). Thirty one healthy subjects with such atypical MP spatial profiles were assigned to one of three intervention groups: Group 1: (n = 10), 20 mg/day lutein (L), 2 mg/day zeaxanthin (Z); Group 2: (n = 10), 10 mg/day meso-zeaxanthin (MZ), 10 mg/day L, 2 mg/day Z; Group 3: (n = 10), 17 mg/day MZ, 3 mg/day L, 2 mg/day Z. Subjects were instructed to take one capsule daily over an 8-week period. MP at 0.25°, 0.5°, 1°, 1.75° and 3° was measured using customized-heterochromatic flicker photometry at baseline, four weeks and 8 weeks. Over the study period, we report no statistically significant increase in MP at any eccentricity in Group 1 (p > 0.05, for all eccentricities). There was a trend towards an increase in MP at all eccentricities in Group 2, with a significant increase found at 0.25° and 0.50° (p = 0.000 and p = 0.016, respectively). There was a statistically significant increase evident in MP at 0.25° in Group 3 (p = 0.005), but at no other eccentricity (p > 0.05, for all other). We report that the typical central peak of MP can be realised in subjects with atypical spatial profiles, following supplementation with a preparation containing all three macular carotenoids, but not with a supplement lacking MZ. The implications of our findings, in terms of visual performance and/or a (photo)-protective effect, warrant additional study.
Do Massive Open Online Course Platforms Support Employability?

Past research suggests that many individuals take Massive Open Online Courses (MOOCs) for employment-related reasons. It is unclear, however, how learners leverage MOOCs for employment and how effectively these platforms support employability. To explore this further, we surveyed 441 learners and interviewed 22 learners motivated to take MOOCs for reasons related to financial limitations and/or reasons related to employment. Using the three dimensions of employability as a frameworkâhuman and social capital, career identity, and personal adaptabilityâwe find that while most of our participants were optimistic about the potential for MOOCs to improve their employability, there was very limited tangible evidence of employment mobility from taking MOOCs. Though MOOCs support human capital, there are opportunities to further support social capital, career identity, and personal adaptability. We contribute a deeper understanding of learners who use MOOCs for employment and provide concrete design implications for MOOC platforms to better support employability in the future. We found very few low SES learners using MOOCs for reasons of employment and identify opportunities for MOOCs to reach and support these learners.
A systematic review of shockwave therapies in soft tissue conditions: focusing on the evidence.

BACKGROUND
'Shock wave' therapies are now extensively used in the treatment of musculoskeletal injuries. This systematic review summarises the evidence base for the use of these modalities.


METHODS
A thorough search of the literature was performed to identify studies of adequate quality to assess the evidence base for shockwave therapies on pain in specific soft tissue injuries. Both focused extracorporeal shockwave therapy (F-ESWT) and radial pulse therapy (RPT) were examined.


RESULTS
23 appropriate studies were identified. There is evidence for the benefit of F-ESWT and of RPT in a number of soft tissue musculoskeletal conditions, and evidence that both treatment modalities are safe. There is evidence that F-ESWT is effective in the treatment of plantar fasciitis, calcific tendinitis, and that RPT is effective in plantar fasciitis. Where benefit is seen in F-ESWT, it appears to be dose dependent, with greater success seen with higher dose regimes. There is low level evidence for lack of benefit of low-dose F-ESWT and RPT in non-calcific rotator cuff disease and mixed evidence in lateral epicondylitis.
Machine learning application in MOOCs: Dropout prediction

Massive Open Online Course(MOOC) is undergoing explosive growth recently, both the number of MOOC platforms and courses are increasing dramatically during these years. One of the major concerns in MOOC is high dropout rate, we study dropout prediction in MOOCs, using student's learning activities data in a period of time to measure how likely students would drop out in next couple of days. We collect 39 courses data from XuetangX platform, which is based on the open source Edx platform. Using supervised classification approach in the machine learning field, we achieve 89% accuracy in dropout prediction task with gradient boosting decision tree model. We describe details in drop out prediction framework, including data extraction from Edx platform, data preprocessing, feature engineering and performance test on several supervised classification models.
Water Quality Assessment of River Ogun Using Multivariate Statistical Techniques

Variations in water quality of River Ogun around the cattle market, Isheri along Lagos-Ibadan express road were evaluated using multivariate statistical techniques such as principal component analysis (PCA) and cluster analysis (CA) to analyze the similarities or dissimilarities among the sampling points so as to identify spatial and temporal variations in water quality and sources of contamination over time. Water quality data were generated from 8 sampling points during 6 year sampling periods (i.e., 2000, 2005, 2006, 2009, 2010, and 2011). The samples were analyzed for 14 physico-chemical parameters and heavy metals such as temperature, pH, total solids (TS), total dissolved solids (TDS), suspended solids (SS), oil and grease, dissolved oxygen (DO), chemical oxygen demand (COD), Cl, alkalinity, total hardness (TH), , , and heavy metals (Cd, Cu, Fe, Ni, Pb, Mn, and Zn). Three zones were differentiated based on the cluster analysis results, and implied similar water quality features. Thus, the water quality around the site may be categorized as relatively less polluted, moderately polluted and highly polluted. The PCA assisted to extract and recognize the factors responsible for water quality variations over the years. The results showed that the index which changes the quality of the water differs. The natural, inorganic and organic parameters e.g., temperature, TS, and etc., were the most significant parameters contributing to the variations in the water quality over the years. This shows that a parameter that can be significant in contributing to water quality in one season may less or not be significant in another. This result may be used to reduce the number of samples analyzed both in space and time, without much loss of information. This will assist the decision makers in identifying priorities to improve water quality that has deteriorated due to pollution from various anthropogenic activities. 2 4 SO  3 NO  3 4 PO 
BioRuby: bioinformatics software for the Ruby programming language

SUMMARY
The BioRuby software toolkit contains a comprehensive set of free development tools and libraries for bioinformatics and molecular biology, written in the Ruby programming language. BioRuby has components for sequence analysis, pathway analysis, protein modelling and phylogenetic analysis; it supports many widely used data formats and provides easy access to databases, external programs and public web services, including BLAST, KEGG, GenBank, MEDLINE and GO. BioRuby comes with a tutorial, documentation and an interactive environment, which can be used in the shell, and in the web browser.


AVAILABILITY
BioRuby is free and open source software, made available under the Ruby license. BioRuby runs on all platforms that support Ruby, including Linux, Mac OS X and Windows. And, with JRuby, BioRuby runs on the Java Virtual Machine. The source code is available from http://www.bioruby.org/.


CONTACT
katayama@bioruby.org
Genetic analysis of yield and quantitative traits in pigeonpea (Cajanus cajan L. Millsp.)

Basic information on genetics and inheritance of quantitative characters, which is necessary to develop future breeding programme, is not widely studied in pigeonpea. Hence, present study was conducted among 5 generations in four pigeonpea crosses to know significance of additive-dominance model, gene action involved in inheritance of quantitative characters, heritability and genetic advance. “Scaling” and “joint scaling test” was significant for most characters indicating that additive-dominance model alone is not enough to explain the inheritance of a character. Though additive variance was more, dominance variance also played important role for most of the traits. Positive and negative alleles were found to be distributed between parents. Additive gene effect (d) was significant for pods per plant and seeds per pod whereas dominance gene effect (h) was more predominant among pod yield and seed yield. Dominance × Dominance inter-allelic interactions (l) was more important than Additive × Additive type (i) for most of the traits studied which could be exploited by selecting individuals based on their performance in recurrent selection. Complementary gene action was observed among many traits with few exhibiting duplicate gene action. Heritability and genetic advance was high indicating the effectiveness of selection. Since dominance effects is also present along with additive effects selection could be practised in later generations to identify high yielding genotypes.
Inverse solution mapping of epicardial potentials: quantitative comparison with epicardial contact mapping.

BACKGROUND
Catheter ablation of ventricular tachycardia (VT) is still one of the most challenging procedures in cardiac electrophysiology, limited, in part, by unmappable arrhythmias that are nonsustained or poorly tolerated. Calculation of the inverse solution from body surface potential mapping (sometimes known as ECG imaging) has shown tremendous promise and can rapidly map these arrhythmias, but we lack quantitative assessment of its accuracy in humans. We compared inverse solution mapping with computed tomography-registered electroanatomic epicardial contact catheter mapping to study the resolution of this technique, the influence of myocardial scar, and the ability to map VT.


METHODS AND RESULTS
For 4 patients undergoing epicardial catheter mapping and ablation of VT, 120-lead body surface potential mappings were obtained during implantable defibrillator pacing, catheter pacing from 79 epicardial sites, and induced VT. Inverse epicardial electrograms computed using individualized torso/epicardial surface geometries extracted from computed tomography images were compared with registered electroanatomic contact maps. The distance between estimated and actual epicardial pacing sites was 13 ± 9 mm over normal myocardium with no stimulus-QRS delay but increased significantly over scar (P=0.013) or was close to scar (P=0.014). Contact maps during right ventricular pacing correlated closely to inverse solution isochrones. Maps of inverse epicardial potentials during 6 different induced VTs indicated areas of earliest activation, which correlated closely with clinically identified VT exit sites for 2 epicardial VTs.


CONCLUSIONS
Inverse solution maps can identify sites of epicardial pacing with good accuracy, which diminishes over myocardial scar or over slowly conducting tissue. This approach can also identify epicardial VT exit sites and ventricular activation sequences.
A phase 2 study of vorinostat in acute myeloid leukemia.

BACKGROUND
This two-stage, multi-institutional, randomized phase 2 trial assessed the toxicity and response rate associated with two treatment schedules of the histone deacetylase inhibitor, vorinostat (suberoylanilide hydroxamic acid; SAHA) in patients with relapsed acute myeloid leukemia and in selected untreated patients with high-risk acute myeloid leukemia.


DESIGN AND METHODS
Patients with relapsed or untreated acute myeloid leukemia who were not candidates for chemotherapy entered one of the two treatment arms. In both arms a total dose of 8400 mg of vorinostat was delivered in each 21-day cycle of treatment: in arm A the dose regimen was 400 mg daily whereas in arm B the dose regimen was 200 mg three times daily for 14 days followed by 1 week rest.


RESULTS
Data from all 37 patients were used for the analyses. In arm A (n=15), the confirmed complete remission rate was 0% (95% CI, 0% to 23%); this arm was closed at the planned interim analysis. In arm B (n=22), the confirmed complete remission rate was 4.5% (1 response; 95% CI, 0.4% to 24%), with a duration of response exceeding 398 days. The median time to treatment failure in arm A was 42 days (95% CI, 26 to 57); although a minimum of four cycles of treatment were planned, 11 patients (79%) received no more than two cycles. The median time to treatment failure in arm B was 46 days (95% CI, 20 to 71); 13 patients (59%) received no more than two cycles of treatment.


CONCLUSIONS
Vorinostat monotherapy demonstrated minimal activity in this group of patients with acute myeloid leukemia. Therapy was discontinued in many patients before the planned four cycles had been administered, either because of failure of vorinostat to control the leukocyte count or patients' and physicians' preference. Future studies of vorinostat in acute myeloid leukemia should focus on combinations with other drugs with which it might interact pharmacodynamically. ClinicalTrials.gov Identifier: NCT00305773.
Beneficial psychological effects of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in healthy human volunteers.

*Correspondence to: Michaël Messaoudi; Email: mmessaoudi@etap-lab.com In a recent clinical study, we demonstrated in the general population that Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 (PF) taken in combination for 30 days decreased the global scores of hospital anxiety and depression scale (HADs), and the global severity index of the Hopkins symptoms checklist (HSCL90), due to the decrease of the sub-scores of somatization, depression and angerhostility spheres. Therefore, oral intake of PF showed beneficial effects on anxiety and depression related behaviors in human volunteers. From there, it is interesting to focus on the role of this probiotic formulation in the subjects with the lowest urinary free cortisol levels at baseline. This addendum presents a secondary analysis of the effects of PF in a subpopulation of 25 subjects with urinary free cortisol (UFC) levels less than 50 ng/ml at baseline, on psychological distress based on the percentage of change of the perceived stress scale (PSs), the HADs and the HSCL-90 scores between baseline and follow-up. The data show that PF improves the same scores as in the general population (the HADs global score, the global severity index of the HSCL-90 and three of its sub-scores, i.e., somatization, depression and anger-hostility), as well as the PSs score and three other subscores of the HSCL-90, i.e., “obsessive compulsive,” “anxiety” and “paranoidideation.” Moreover, in the HSCL-90, Beneficial psychological effects of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in healthy human volunteers
Combining content-based and collaborative recommendations: A hybrid approach based on Bayesian networks

Recommender systems enable users to access products or articles that they would otherwise not be aware of due to the wealth of information to be found on the Internet. The two traditional recommendation techniques are content-based and collaborative filtering. While both methods have their advantages, they also have certain disadvantages, some of which can be solved by combining both techniques to improve the quality of the recommendation. The resulting system is known as a hybrid recommender system. In the context of artificial intelligence, Bayesian networks have been widely and successfully applied to problems with a high level of uncertainty. The field of recommendation represents a very interesting testing ground to put these probabilistic tools into practice. This paper therefore presents a new Bayesian network model to deal with the problem of hybrid recommendation by combining content-based and collaborative features. It has been tailored to the problem in hand and is equipped with a flexible topology and efficient mechanisms to estimate the required probability distributions so that probabilistic inference may be performed. The effectiveness of the model is demonstrated using the MovieLens and IMDB data sets. 2010 Elsevier Inc. All rights reserved.
Outcomes of men with screen-detected prostate cancer eligible for active surveillance who were managed expectantly.

BACKGROUND
The incidence of small, localised, well-differentiated prostate cancer (PCa) is increasing, mainly as a result of screening. Many of these cancers will not progress, and radical therapy may lead to substantial overtreatment. Active surveillance (AS) has emerged as an alternative.


OBJECTIVE
To retrospectively validate the currently used criteria for eligibility for AS.


DESIGN, SETTING, AND PARTICIPANTS
For this cohort study, data from 616 men who were diagnosed with PCa between 1994 and 2007 at a mean age of 66.3 yr in four centres of the European Randomized Study of Screening for Prostate Cancer (ERSPC) were combined. All patients fit the criteria for AS (prostate-specific antigen [PSA] < or = 10.0 ng/ml, PSA-density < 0.2 ng/ml per ml, stage T1C/T2, Gleason score < or = 3 + 3 = 6, and < or = 2 positive biopsy cores), and initially they were managed expectantly. Median follow-up was 3.91 yr.


MEASUREMENTS
Disease specific-, overall-, and treatment-free survival were studied. Present PSA characteristics were assessed and also compared between men who were switching to deferred active therapy during follow-up and men remaining untreated.


RESULTS AND LIMITATIONS
The calculated (Kaplan-Meier) 10-yr PCa-specific survival (21 patients at risk) was 100%, which sharply contrasted with 77% overall survival. Men still alive showed favourable PSA characteristics. Although the calculated 10-yr treatment-free survival was only 43%, objective signs of progression often did not indicate the shift to radical treatment. The cohort consisted of men on AS and those on watchful waiting (WW); information on comorbidity or psychological distress was not available.


CONCLUSIONS
AS seems justified in selected men with screen-detected PCa. Prospective protocol-based AS programs are necessary to optimise selection criteria and to find the appropriate trigger points for switching to active therapy. Possible negative psychological reactions with AS against improved quality of life by withholding side-effects from radical treatment should be considered.