LLukas22/scidocs huggingface dataset:
Advanced practice nursing roles: development, implementation and evaluation.

AIM
The aim of this paper is to discuss six issues influencing the introduction of advanced practice nursing (APN) roles: confusion about APN terminology, failure to define clearly the roles and goals, role emphasis on physician replacement/support, underutilization of all APN role domains, failure to address environmental factors that undermine the roles, and limited use of evidence-based approaches to guide their development, implementation and evaluation.


BACKGROUND
Health care restructuring in many countries has led to substantial increases in the different types and number of APN roles. The extent to which these roles truly reflect advanced nursing practice is often unclear. The misuse of APN terminology, inconsistent titling and educational preparation, and misguided interpretations regarding the purpose of these roles pose barriers to realizing their full potential and impact on health. Role conflict, role overload, and variable stakeholder acceptance are frequently reported problems associated with the introduction of APN roles.


DISCUSSION
Challenges associated with the introduction of APN roles suggests that greater attention to and consistent use of the terms of the terms advanced nursing practice, advancement and advanced practice nursing is required. Advanced nursing practice refers to the work or what nurses do in the role and is important for defining the specific nature and goals for introducing new APN roles. The concept of advancement further defines the multi-dimensional scope and mandate of advanced nursing practice and distinguishes differences from other types of nursing roles. Advanced practice nursing refers to the whole field, involving a variety of such roles and the environments in which they exist. Many barriers to realizing the full potential of these roles could be avoided through better planning and efforts to address environmental factors, structures, and resources that are necessary for advanced nursing practice to take place.


CONCLUSIONS
Recommendations for the future introduction of APN roles can be drawn from this paper. These include the need for a collaborative, systematic and evidence-based process designed to provide data to support the need and goals for a clearly defined APN role, support a nursing orientation to advanced practice, promote full utilization of all the role domains, create environments that support role development, and provide ongoing evaluation of these roles related to predetermined goals.
The cost-effectiveness and public health benefit of nalmefene added to psychosocial support for the reduction of alcohol consumption in alcohol-dependent patients with high/very high drinking risk levels: a Markov model

OBJECTIVES
To determine whether nalmefene combined with psychosocial support is cost-effective compared with psychosocial support alone for reducing alcohol consumption in alcohol-dependent patients with high/very high drinking risk levels (DRLs) as defined by the WHO, and to evaluate the public health benefit of reducing harmful alcohol-attributable diseases, injuries and deaths.


DESIGN
Decision modelling using Markov chains compared costs and effects over 5 years.


SETTING
The analysis was from the perspective of the National Health Service (NHS) in England and Wales.


PARTICIPANTS
The model considered the licensed population for nalmefene, specifically adults with both alcohol dependence and high/very high DRLs, who do not require immediate detoxification and who continue to have high/very high DRLs after initial assessment.


DATA SOURCES
We modelled treatment effect using data from three clinical trials for nalmefene (ESENSE 1 (NCT00811720), ESENSE 2 (NCT00812461) and SENSE (NCT00811941)). Baseline characteristics of the model population, treatment resource utilisation and utilities were from these trials. We estimated the number of alcohol-attributable events occurring at different levels of alcohol consumption based on published epidemiological risk-relation studies. Health-related costs were from UK sources.


MAIN OUTCOME MEASURES
We measured incremental cost per quality-adjusted life year (QALY) gained and number of alcohol-attributable harmful events avoided.


RESULTS
Nalmefene in combination with psychosocial support had an incremental cost-effectiveness ratio (ICER) of £5204 per QALY gained, and was therefore cost-effective at the £20,000 per QALY gained decision threshold. Sensitivity analyses showed that the conclusion was robust. Nalmefene plus psychosocial support led to the avoidance of 7179 alcohol-attributable diseases/injuries and 309 deaths per 100,000 patients compared to psychosocial support alone over the course of 5 years.


CONCLUSIONS
Nalmefene can be seen as a cost-effective treatment for alcohol dependence, with substantial public health benefits.


TRIAL REGISTRATION NUMBERS
This cost-effectiveness analysis was developed based on data from three randomised clinical trials: ESENSE 1 (NCT00811720), ESENSE 2 (NCT00812461) and SENSE (NCT00811941).
HICO: A Benchmark for Recognizing Human-Object Interactions in Images

We introduce a new benchmark "Humans Interacting with Common Objects" (HICO) for recognizing human-object interactions (HOI). We demonstrate the key features of HICO: a diverse set of interactions with common object categories, a list of well-defined, sense-based HOI categories, and an exhaustive labeling of co-occurring interactions with an object category in each image. We perform an in-depth analysis of representative current approaches and show that DNNs enjoy a significant edge. In addition, we show that semantic knowledge can significantly improve HOI recognition, especially for uncommon categories.
Grounded theory research: literature reviewing and reflexivity.

AIM
This paper is a report of a discussion of the arguments surrounding the role of the initial literature review in grounded theory.


BACKGROUND
Researchers new to grounded theory may find themselves confused about the literature review, something we ourselves experienced, pointing to the need for clarity about use of the literature in grounded theory to help guide others about to embark on similar research journeys.


DISCUSSION
The arguments for and against the use of a substantial topic-related initial literature review in a grounded theory study are discussed, giving examples from our own studies. The use of theoretically sampled literature and the necessity for reflexivity are also discussed. Reflexivity is viewed as the explicit quest to limit researcher effects on the data by awareness of self, something seen as integral both to the process of data collection and the constant comparison method essential to grounded theory.


CONCLUSION
A researcher who is close to the field may already be theoretically sensitized and familiar with the literature on the study topic. Use of literature or any other preknowledge should not prevent a grounded theory arising from the inductive-deductive interplay which is at the heart of this method. Reflexivity is needed to prevent prior knowledge distorting the researcher's perceptions of the data.
k-way Hypergraph Partitioning via n-Level Recursive Bisection

We develop a multilevel algorithm for hypergraph partitioning that contracts the vertices one at a time. Using several caching and lazy-evaluation techniques during coarsening and refinement, we reduce the running time by up to two-orders of magnitude compared to a naive n-level algorithm that would be adequate for ordinary graph partitioning. The overall performance is even better than the widely used hMetis hypergraph partitioner that uses a classical multilevel algorithm with few levels. Aided by a portfolio-based approach to initial partitioning and adaptive budgeting of imbalance within recursive bipartitioning, we achieve very high quality. We assembled a large benchmark set with 310 hypergraphs stemming from application areas such VLSI, SAT solving, social networks, and scientific computing. We achieve significantly smaller cuts than hMetis and PaToH, while being faster than hMetis. Considerably larger improvements are observed for some instance classes like social networks, for bipartitioning, and for partitions with an allowed imbalance of 10%. The algorithm presented in this work forms the basis of our hypergraph partitioning framework KaHyPar (Karlsruhe Hypergraph Partitioning).
Manualized therapy for PTSD: flexing the structure of cognitive processing therapy.

OBJECTIVE
This study tested a modified cognitive processing therapy (MCPT) intervention designed as a more flexible administration of the protocol. Number of sessions was determined by client progress toward a priori defined end-state criteria, "stressor sessions" were inserted when necessary, and therapy was conducted by novice CPT clinicians.


METHOD
A randomized, controlled, repeated measures, semicrossover design was utilized (a) to test the relative efficacy of the MCPT intervention compared with a symptom-monitoring delayed treatment (SMDT) condition and (b) to assess within-group variation in change with a sample of 100 male and female interpersonal trauma survivors with posttraumatic stress disorder (PTSD).


RESULTS
Hierarchical linear modeling analyses revealed that MCPT evidenced greater improvement on all primary (PTSD and depression) and secondary (guilt, quality of life, general mental health, social functioning, and health perceptions) outcomes compared with SMDT. After the conclusion of SMDT, participants crossed over to MCPT, resulting in a combined MCPT sample (n = 69). Of the 50 participants who completed MCPT, 58% reached end-state criteria prior to the 12th session, 8% at Session 12, and 34% between Sessions 12 and 18. Maintenance of treatment gains was found at the 3-month follow-up, with only 2 of the treated sample meeting criteria for PTSD. Use of stressor sessions did not result in poorer treatment outcomes.


CONCLUSIONS
Findings suggest that individuals respond at a variable rate to CPT, with significant benefit from additional therapy when indicated and excellent maintenance of gains. Insertion of stressor sessions did not alter the efficacy of the therapy.
Pantoprazole may enhance antiplatelet effect of enteric-coated aspirin in patients with acute coronary syndrome.

BACKGROUND
Antiplatelet therapy has proven beneficial in the treatment of cardiovascular disease. Proton pump inhibitors (PPIs) are commonly used for gastroprotection in patients receiving antiplatelet therapy. Several trials have been carried out to establish interactions between PPIs, clopidogrel and soluble formulations of aspirin, but no studies with PPIs and enteric-coated (EC) forms of aspirin have been conducted. The aim of this study was to assess if concomitant pantoprazole usage influences antiplatelet effect of EC aspirin in patients with acute coronary syndrome treated with percutaneous coronary intervention (PCI) and dual antiplatelet therapy.


METHODS
Thirty-one consecutive patients were prospectively enrolled in the randomized, crossover, open-labelled designed study. The first 16 patients were given orally 40 mg of pantoprazole for the first four days while the next 15 subjects were treated with pantoprazole from the fifth to the eighth day of hospitalisation. Blood samples were collected at 6.00 a.m., 10.00 a.m., 2.00 p.m., and 7.00 p.m. on the fourth and eighth day of hospitalization. Aggregation in response to arachidonic acid was assessed in the whole blood on a new generation impedance aggregometer.


RESULTS
Lower overall platelet aggregation in patients treated with pantoprazole (p < 0.03) was observed. When aggregation of platelets was analyzed separately at different times, the differences reached statistical significance six hours after the administration of pantoprazole and antiplatelet agents. The highest absolute difference in arachidonic acid-dependent aggregation was observed two hours after drug ingestion.


CONCLUSIONS
Co-administration of pantoprazole may enhance the antiplatelet effect of enteric-coated aspirin in patients with acute coronary syndrome undergoing PCI.
Functional roles of nucleosome stability and dynamics.

Nucleosome is a histone-DNA complex known as the fundamental repeating unit of chromatin. Up to 90% of eukaryotic DNA is wrapped around consecutive octamers made of the core histones H2A, H2B, H3 and H4. Nucleosome positioning affects numerous cellular processes that require robust and timely access to genomic DNA, which is packaged into the tight confines of the cell nucleus. In living cells, nucleosome positions are determined by intrinsic histone-DNA sequence preferences, competition between histones and other DNA-binding proteins for genomic sequence, and ATP-dependent chromatin remodelers. We discuss the major energetic contributions to nucleosome formation and remodeling, focusing especially on partial DNA unwrapping off the histone octamer surface. DNA unwrapping enables efficient access to nucleosome-buried binding sites and mediates rapid nucleosome removal through concerted action of two or more DNA-binding factors. High-resolution, genome-scale maps of distances between neighboring nucleosomes have shown that DNA unwrapping and nucleosome crowding (mutual invasion of nucleosome territories) are much more common than previously thought. Ultimately, constraints imposed by nucleosome energetics on the rates of ATP-dependent and spontaneous chromatin remodeling determine nucleosome occupancy genome-wide, and shape pathways of cellular response to environmental stresses.
Potential-based bounded-cost search and Anytime Non-Parametric A*

Article history: Received 1 May 2012 Received in revised form 1 May 2014 Accepted 3 May 2014 Available online 10 May 2014
Sets with Cardinality Constraints in Satisfiability Modulo Theories

Boolean Algebra with Presburger Arithmetic (BAPA) is a decidable logic that can express constraints on sets of elements and their cardinalities. Problems from verification of complex properties of software often contain fragments that belong to quantifier-free BAPA (QFBAPA). Deciding the satisfiability of QFBAPA formulas has been shown to be NP-complete using an eager reduction to quantifier-free Presburger arithmetic that exploits a sparse-solution property. In contrast to many other NP-complete problems (such as quantifier-free firstorder logic or linear arithmetic), the applications of QFBAPA to a broader set of problems has so far been hindered by the lack of an efficient implementation that can be used alongside other efficient decision procedures. We overcome these limitations by extending the efficient SMT solver Z3 with the ability to reason about cardinality constraints. Our implementation uses the DPLL(T ) mechanism of Z3 to reason about the top-level propositional structure of a QFBAPA formula, improving the efficiency compared to previous implementations. Moreover, we present a new algorithm for automated decomposition of QFBAPA formulas. Our algorithm alleviates the exponential explosion of considering all Venn regions, significantly improving the tractability of formulas with many set variables. Because it is implemented as a theory plugin, our implementation enables Z3 to prove formulas that use QFBAPA constructs alongside constructs from other theories that Z3 supports (e.g. linear arithmetic, uninterpreted function symbols, algebraic data types), as well as in formulas with quantifiers. We have applied our implementation to verification of functional programs; we show it can automatically prove formulas that no automated approach was reported to be able to prove before.
Concatenated p-mean Word Embeddings as Universal Cross-Lingual Sentence Representations

Average word embeddings are a common baseline for more sophisticated sentence embedding techniques. However, they typically fall short of the performances of more complex models such as InferSent. Here, we generalize the concept of average word embeddings to power mean word embeddings. We show that the concatenation of different types of power mean word embeddings considerably closes the gap to state-of-the-art methods monolingually and substantially outperforms these more complex techniques crosslingually. In addition, our proposed method outperforms different recently proposed baselines such as SIF and Sent2Vec by a solid margin, thus constituting a much harder-to-beat monolingual baseline. Our data and code are publicly available.1
Attention to visual speech gestures enhances hemodynamic activity in the left planum temporale.

Observing a speaker's articulatory gestures can contribute considerably to auditory speech perception. At the level of neural events, seen articulatory gestures can modify auditory cortex responses to speech sounds and modulate auditory cortex activity also in the absence of heard speech. However, possible effects of attention on this modulation have remained unclear. To investigate the effect of attention on visual speech-induced auditory cortex activity, we scanned 10 healthy volunteers with functional magnetic resonance imaging (fMRI) at 3 T during simultaneous presentation of visual speech gestures and moving geometrical forms, with the instruction to either focus on or ignore the seen articulations. Secondary auditory cortex areas in the bilateral posterior superior temporal gyrus and planum temporale were active both when the articulatory gestures were ignored and when they were attended to. However, attention to visual speech gestures enhanced activity in the left planum temporale compared to the situation when the subjects saw identical stimuli but engaged in a nonspeech motion discrimination task. These findings suggest that attention to visually perceived speech gestures modulates auditory cortex function and that this modulation takes place at a hierarchically relatively early processing level.
Seasonal variations in air-water exchange of polychlorinated biphenyls in lake superior.

Instantaneous and seasonal fluxes of polychlorinated biphenyls (PCBs) across the Lake Superior air-water interface were predicted using a modified two-film gasexchange model. Instantaneous fluxes of CPCB (sum of 80 congeners) were calculated from air and water samples collected simultaneously during short cruises in 1988,1990, and 1992. Volatilization fluxes dominated in late summer in warmer waters (15-22 "C) while CPCBs were deposited into cool springtime waters (-2 "C). Seasonal fluxes were calculated using air samples collected at 12-day intervals over 2 years (1991-1992). Gas-phase CPCB exhibited two concentration maxima: in May and in August. The monthly average homolog concentrations were modeled as the sum of two Lorentzian functions and applied to the two-film gas-exchange model. The largest volatilization fluxes were calculated for fall, when water temperatures were relatively warm (7-10 "C) and vapor PCB concentrations were low (-65 pg/m3). Vapor deposition to Lake Superior is indicated from late April through May, into 0-3 "C water when vapor CPCB concentrations peak at -200 pg/m3. The annual CPCB flux from Lake Superior for 1992 is 250 kg/yr.
Pathophysiology of Peyronie's disease

Peyronie's disease is an inflammatory condition characterized by the formation of fibrous, noncompliant nodules in the tunica albuginea which can impede tunical expansion during penile erection, leading to deformity and bending. While the cause of this disease is thought to be due to microvascular trauma and abnormal wound healing, other hypotheses include genetic predisposition. In this review the pathophysiology of Peyronie's disease is discussed as well as current hypothese regarding its origin.
Decision Tree Algorithms Predict the Diagnosis and Outcome of Dengue Fever in the Early Phase of Illness

BACKGROUND
Dengue is re-emerging throughout the tropical world, causing frequent recurrent epidemics. The initial clinical manifestation of dengue often is confused with other febrile states confounding both clinical management and disease surveillance. Evidence-based triage strategies that identify individuals likely to be in the early stages of dengue illness can direct patient stratification for clinical investigations, management, and virological surveillance. Here we report the identification of algorithms that differentiate dengue from other febrile illnesses in the primary care setting and predict severe disease in adults.


METHODS AND FINDINGS
A total of 1,200 patients presenting in the first 72 hours of acute febrile illness were recruited and followed up for up to a 4-week period prospectively; 1,012 of these were recruited from Singapore and 188 from Vietnam. Of these, 364 were dengue RT-PCR positive; 173 had dengue fever, 171 had dengue hemorrhagic fever, and 20 had dengue shock syndrome as final diagnosis. Using a C4.5 decision tree classifier for analysis of all clinical, haematological, and virological data, we obtained a diagnostic algorithm that differentiates dengue from non-dengue febrile illness with an accuracy of 84.7%. The algorithm can be used differently in different disease prevalence to yield clinically useful positive and negative predictive values. Furthermore, an algorithm using platelet count, crossover threshold value of a real-time RT-PCR for dengue viral RNA, and presence of pre-existing anti-dengue IgG antibodies in sequential order identified cases with sensitivity and specificity of 78.2% and 80.2%, respectively, that eventually developed thrombocytopenia of 50,000 platelet/mm(3) or less, a level previously shown to be associated with haemorrhage and shock in adults with dengue fever.


CONCLUSION
This study shows a proof-of-concept that decision algorithms using simple clinical and haematological parameters can predict diagnosis and prognosis of dengue disease, a finding that could prove useful in disease management and surveillance.
A New Incompleteness Result for Hoare's System

A structure A is presented for which Hoare's formal system for partial correctness is incomplete, even if the entire first-order theory of A is included among the axioms. It follows that the language of first-order logic is insufficient to express all loop invariants. The implications of this result for program-proving are discussed.
Portraying Witnesses. The Apostles in Early Christian Art and Poetry, written by Dijkstra, R.

Bespreking van: Roald Dijkstra,Portraying Witnesses. The Apostles in Early Christian Art and Poetry s.l.:s.n. ,2014 978-94-6259-163-9
Effectiveness of computer-generated (virtual reality) graded exposure in the treatment of acrophobia.

OBJECTIVE
The authors' goal was to examine the efficacy of computer-generated (virtual reality) graded exposure in the treatment of acrophobia (fear of heights).


METHOD
Twenty college students with acrophobia were randomly assigned to virtual reality graded exposure treatment (N = 12) or to a waiting-list comparison group (N = 8). Seventeen students completed the study. Sessions were conducted individually over 8 weeks. Outcome was assessed by using measures of anxiety, avoidance, attitudes, and distress associated with exposure to heights before and after treatment.


RESULTS
Significant differences between the students who completed the virtual reality treatment (N = 10) and those on the waiting list (N = 7) were found on all measures. The treatment group was significantly improved after 8 weeks, but the comparison group was unchanged.


CONCLUSIONS
The authors conclude that treatment with virtual reality graded exposure was successful in reducing fear of heights.