LLukas22/scidocs huggingface dataset:
Coronary plaque classification with intravascular ultrasound radiofrequency data analysis.

BACKGROUND
Atherosclerotic plaque stability is related to histological composition. However, current diagnostic tools do not allow adequate in vivo identification and characterization of plaques. Spectral analysis of backscattered intravascular ultrasound (IVUS) data has potential for real-time in vivo plaque classification.


METHODS AND RESULTS
Eighty-eight plaques from 51 left anterior descending coronary arteries were imaged ex vivo at physiological pressure with the use of 30-MHz IVUS transducers. After IVUS imaging, the arteries were pressure-fixed and corresponding histology was collected in matched images. Regions of interest, selected from histology, were 101 fibrous, 56 fibrolipidic, 50 calcified, and 70 calcified-necrotic regions. Classification schemes for model building were computed for autoregressive and classic Fourier spectra by using 75% of the data. The remaining data were used for validation. Autoregressive classification schemes performed better than those from classic Fourier spectra with accuracies of 90.4% for fibrous, 92.8% for fibrolipidic, 90.9% for calcified, and 89.5% for calcified-necrotic regions in the training data set and 79.7%, 81.2%, 92.8%, and 85.5% in the test data, respectively. Tissue maps were reconstructed with the use of accurate predictions of plaque composition from the autoregressive classification scheme.


CONCLUSIONS
Coronary plaque composition can be predicted through the use of IVUS radiofrequency data analysis. Autoregressive classification schemes performed better than classic Fourier methods. These techniques allow real-time analysis of IVUS data, enabling in vivo plaque characterization.
Providing patient education: impact on quantity and quality of family health history collection

Background: Family health history (FHH) is an underutilized tool in primary care to identify and risk-stratify individuals with increased cancer risk. Objective: Evaluate the influence of patient education on quantity and quality of FHH entered into a primary care-based software program, and impact on the program’s cancer risk management recommendations. Design: Two primary care practices within a larger type II hybrid implementation-effectiveness controlled clinical trial. Participants: English speaking non-adopted patients with a well visit appointment December 2012–March 2013. Interventions: One to two weeks prior to their well visit appointment, participants entered their FHH into the program. Participants were then provided educational materials describing key FHH components. They were instructed to use the interval to collect additional FHH information. Patients then returned for their scheduled appointment, and updated their FHH with any new information. Main Measures: Percentage per pedigree of relatives meeting individual quality criteria. Changes made after patient education and changes to recommendations for surveillance, chemoprevention or genetic counseling referral. Key Results: Post patient education, pedigrees exhibited a greater percentage (per pedigree) of: deceased relatives with age at death (84 vs. 81 % p = 0.02), deceased relatives with cause of death (91 vs. 87 % p = 0.02), relatives with a named health condition (45 vs. 42 % p = 0.002), and a greater percentage of relatives with high quality records (91 vs. 89 % p = 0.02). Of 43 participants with pedigree changes that could trigger changes in risk stratified prevention recommendations, 12 participants (28 %) received such changes. Conclusions: Patient education improves FHH collection and subsequent risk stratification utilized in providing actionable evidence-based care recommendations for cancer risk management.
Exploiting Memory Device Wear-Out Dynamics to Improve NAND Flash Memory System Performance

This paper advocates a device-aware design strategy to improve various NAND flash memory system performance metrics. It is well known that NAND flash memory program/erase (PE) cycling gradually degrades memory device raw storage reliability, and sufficiently strong error correction codes (ECC) must be used to ensure the PE cycling endurance. Hence, memory manufacturers must fabricate enough number of redundant memory cells geared to the worst-case device reliability at the end of memory lifetime. Given the memory device wear-out dynamics, the existing worst-case oriented ECC redundancy is largely under-utilized over the entire memory lifetime, which can be adaptively traded for improving certain NAND flash memory system performance metrics. This paper explores such device-aware adaptive system design space from two perspectives, including (1) how to improve memory program speed, and (2) how to improve memory defect tolerance and hence enable aggressive fabrication technology scaling. To enable quantitative evaluation, we for the first time develop a NAND flash memory device model to capture the effects of PE cycling from the system level. We carry out simulations using the DiskSim-based SSD simulator and a variety of traces, and the results demonstrate up to 32% SSD average response time reduction. We further demonstrate that the potential on achieving very good defect tolerance, and finally show that these two design approaches can be readily combined together to noticeably improve SSD average response time even in the presence of high memory defect rates.
The use of soft silicone solid implant molded intraoperatively for pectus excavatum surgical repair

OBJECTIVE
To describe a new surgical technique to treat pectus excavatum utilizing low hardness solid silicone block that can be carved during the intraoperative period promoting a better aesthetic result.


METHODS
Between May 1994 and February 2013, 34 male patients presenting pectus excavatum were submitted to surgical repair with the use of low hardness solid silicone block, 10 to 30 Shore A. A block-shaped parallelepiped was used with height and base size coinciding with those of the bone defect. The block was carved intraoperatively according to the shape of the dissected space. The patients were followed for a minimum of 120 days postoperatively. The results and the complications were recorded.


RESULTS
From the 34 patients operated on, 28 were primary surgeries and 6 were secondary treatment, using other surgical techniques, bone or implant procedures. Postoperative complications included two case of hematomas and eight of seromas. It was necessary to remove the implant in one patient due to pain, and review surgery was performed in another to check prothesis dimensions. Two patients were submitted to fat grafting to improve the chest wall contour. The result was considered satisfactory in 33 patients.


CONCLUSION
The procedure proved to be fast and effective. The results of carved silicone block were more effective for allowing a more refined contour as compared to custom made implants.
SPECKLE SUPPRESSION THROUGH DUAL IMAGING POLARIMETRY, AND A GROUND-BASED IMAGE OF THE HR 4796A CIRCUMSTELLAR DISK

We demonstrate the versatility of a dual imaging polarimeter working in tandem with a Lyot coronagraph and Adaptive Optics to suppress the highly static speckle noise pattern—the greatest hindrance to ground-based direct imaging of planets and disks around nearby stars. Using a double difference technique with the polarimetric data, we quantify the level of speckle suppression, and hence improved sensitivity, by placing an ensemble of artificial faint companions into real data, with given total brightness and polarization. For highly polarized sources within 0.5, we show that we achieve 3 to 4 magnitudes greater sensitivity through polarimetric speckle suppression than simply using a coronagraph coupled to a high-order Adaptive Optics system. Using such a polarimeter with a classical Lyot coronagraph at the 3.63-m AEOS telescope, we have obtained a 6.5σ detection in the H-band of the 76 AU diameter circumstellar debris disk around the star HR 4796A. Our data represent the first ground-based image of the HR 4796A debris disk and clearly show the two outer ansae of the disk, evident in Hubble Space Telescope NICMOS/STIS imaging. Comparing our peak linearly polarized flux with the total intensity in the lobes as observed by NICMOS, we derive a lower limit to the fractional linear polarization of > 29% caused by dust grains in the disk. In addition, we fit simple morphological models of optically thin disks to our data allowing us to constrain the dust disk scale height (2.5 −1.3 AU) and scattering asymmetry parameter (g=<cos θ>= 0.20 +.07 −.10). These values are consistent with several lines of evidence suggesting that the HR 4796A disk is dominated by a micron-sized dust population, and are indeed typical of disks in transition between those surrounding the Herbig Ae stars to those associated with Vega-like stars. Subject headings: instrumentation: adaptive optics — methods: data analysis — stars: individual (HR 4796A)techniques: image processing —
Dermatitis caused by arthropods in domestic environment: an Italian multicentre study.

BACKGROUND
Skin diseases caused by mites and insects living in domestic environments have been rarely systematically studied.


OBJECTIVES
To study patients with dermatitis induced by arthropods in domestic environment describing their clinical features, isolating culprit arthropods and relating the clinical features to the parasitological data.


METHODS
The study was performed in 105 subjects with clinical and anamnestic data compatible with the differential diagnosis of ectoparasitoses in domestic environments. Clinical data and arthropods findings obtained by indoor dust direct examination were studied.


RESULTS
Indoor dust direct examination demonstrated possible arthropods infestation in 98 subjects (93.3%), more frequently mites (56.1%) (mainly Pyemotes ventricosus and Glycyphagus domesticus) than insects (43.9%) (mainly Formicidae and Bethylidae). Strophulus (46.9%) and urticaria-like eruption (36.7%) in upper limbs and trunk with severe extent were prevalent. Itch was mostly severe (66.3%) and continuous (55.1%). Ectoparasitoses occurred frequently with acute course in summer (44.9%) and spring (30.6%).


CONCLUSIONS
Possible correlation between clinical and aetiological diagnosis of arthropods ectoparasitoses in domestic environments needs the close cooperation between dermatologist and parasitologist. This is crucial to successfully and definitely resolve skin lesions by eradicating the factors favouring infestation.
Gas sensors: A review

In this paper a review of different technologies for gas sensors is presented. The different types of gas sensors technologies including catalytic gas sensor, electrochemical gas sensors, thermal conductivity gas sensor, optical gas sensor and acoustic gas sensor are discussed together with their principle of operation. The Surface Acoustic Wave Gas Sensor technology is discussed in greater detail. The advantages and disadvantages of each sensor technology are also highlighted. All these technologies have been used for several decades for the development of highly sensitive and responsive gas sensors for the detection of flammable and hazardous gases. However, for improved sensitivity and selectivity for these sensors, future trends and outlook for researchers are suggested in the conclusion of this article. Copyright © 2014 IFSA Publishing, S. L.
Experimental investigation of geyser boiling in an annular two-phase closed thermosyphon

-Geyser boiling in a vertical annular two-phase closed thermosyphon was experimentally studied. The effects of the heat load, condenser temperature, degree of liquid fill and length of the evaporator on the characteristics of the geyser boiling were investigated in detail for both water and ethanol as working fluids. Flow visualization at light heat load clearly illustrates the process of geyser boiling. It also indicates that it occurs more frequently and irregularly at high heat load. The wall temperature measurement dictates that the period of geyser boiling is shorter at a higher heat load, a shorter evaporator length and a smaller liquid fill. Additionally, the heat transfer coefficient is found to increase approximately linearly with the heat load on a logarithmic scale. An empirical equation was proposed to correlate the data for the heat transfer coefficient. A criterion was suggested for the occurrence of geyser boiling based on the present data.
Hysteroscopic Resection in Fertility-Sparing Surgery for Atypical Hyperplasia and Endometrial Cancer: Safety and Efficacy.

STUDY OBJECTIVES
To evaluate the rate of intrauterine adhesions after hysteroscopic resection of hyperplastic and/or cancer areas and the efficacy of combined treatment.


DESIGN
Observational retrospective study.


SETTING
Patients affected by endometrial atypical hyperplasia of the endometrium or early stage endometrial carcinoma.


PATIENTS
Twenty-three patients, up to 45 years of age.


INTERVENTION
Conservative treatment based on hysteroscopic resection of hyperplastic and/or cancer areas and subsequent therapy with megestrol acetate 160 mg/day.


METHODS AND MAIN RESULTS
Approximately 5% of endometrial cancers (ECs) are diagnosed in women younger than 40 years old, usually with a good prognosis. From 2010 to 2014, 23 patients, up to age 45 years, who were affected by endometrial cancer (EC) grade 1 or atypical complex hyperplasia (ACH) and who wished to preserve fertility, underwent conservative treatment based on hysteroscopic resection of the hyperplastic and/or cancer areas and subsequent therapy with megestrol acetate 160 mg/day. Data with regard to age, body mass index, symptoms, history of infertility, and previous assisted reproductive technologies attempts, obstetrics history, previous diagnosis of intrauterine sinechiae, hysteroscopic findings, duration of therapy, follow-up reports, and reproductive outcomes were collected and analyzed. Of the 23 patients enrolled in the study, 3 patients (13%) presented with an endometrioid EC grade 1, and 20 patients (87%) had ACH. Twelve patients (52.2%) had complete remission after 3 months of progestin therapy, 9 patients (39.1%) had a complete remission after 6 months, and 2 (8.7%) patients had remission after 9 months. Six patients underwent a second hysteroscopic resection. The 3 patients with an initial diagnosis of EC had complete remission after a mean of 4 months of high-dose progestin therapy; in patients with ACH, remission occurred after a mean of 3 months. In all patients, intrauterine adhesions were not detected at any follow-up diagnostic hysteroscopy. After a median follow-up time of 25 months (range 8-37), we registered 1 (4.3%) relapse of disease. A total of 7 pregnancies in 6 patients were counted, after an average time of 7.4 months (range 3-13 months) after the end of progestin therapy.


CONCLUSIONS
Hysteroscopic resection of hyperplastic and/or cancer areas before high dosage progestin therapy seems to be a safe and effective approach in the management of ACH and in patients with early EC who wish to preserve fertility.
PIK3R1 mutations in SHORT syndrome.

SHORT syndrome (OMIM 269880) is a rare autosomal-dominant disorder characterized by short stature, hyperextensibility of joints, hernias, ocular depression, ophthalmic anomalies (Rieger anomaly, posterior embryotoxon, glaucoma), teething delay, partial lipodystrophy, insulin resistance and facial dysmorphic signs. Heterozygous mutations in PIK3R1 were recently identified in 14 families with SHORT syndrome. Eight of these families had a recurrent missense mutation (c.1945C>T; p.Arg649Trp). We report on two unrelated patients with typical clinical features of SHORT syndrome and additional problems such as pulmonary stenosis and ectopic kidney. Analysis of PIK3R1 revealed the mutation c.1945C>T; p.Arg649Trp de novo in both patients. These two patients not only provide additional evidence that PIK3R1 mutations cause SHORT syndrome, but also broaden the clinical spectrum of this syndrome and further confirm that the amino acid exchange c.1945C>T; p.Arg649Trp is a hotspot mutation in this gene.
A Comprehensive Gold Standard for the Enron Organizational Hierarchy

Many researchers have attempted to predict the Enron corporate hierarchy from the data. This work, however, has been hampered by a lack of data. We present a new, large, and freely available gold-standard hierarchy. Using our new gold standard, we show that a simple lower bound for social network-based systems outperforms an upper bound on the approach taken by current NLP systems.
Glacial activity and catchment dynamics in northwest Greece: Long-term river behaviour and the slackwater sediment record for the last glacial to interglacial transition☆

Article History: Pleistocene glacial activity t Accepted 25 April 2008 Available online 25 May 2008
Agile estimation using people and project related factors

The key measures of any project about its perfectness are ability to complete in the scheduled time and within the estimated cost. Cost and effort are important factors whenever a project is developed. The estimation of cost and effort is a difficult task in Agile environment. It has been observed that the current Agile methods mostly depends on an expert opinion, planning poker and historical data of project for estimation of cost, size, effort and duration. In absence of the historical data and experts the previous methods are not efficient. So there is need of an algorithmic method, which can calculate cost and effort of the project. In this direction S.Bhalero, Maya Ingel [2] has considered some project-related factors that calculate the size as well as duration of the project. However, several other project as well as people related factors may affect the Agile environment. In this work an Algorithmic estimation method is being proposed considering various factors thereby estimating the more accurate release date, cost, effort and duration for the project. The effectiveness and feasibility of the proposed algorithm has been shown by considering three cases in which different levels of factors are taken and compared.
Resolving "You" in Multi-Party Dialog

This paper presents experiments into the resolution of “you” in multi-party dialog, dividing this process into two tasks: distinguishing between generic and referential uses; and then, for referential uses, identifying the referred-to addressee(s). On the first task we achieve an accuracy of 75% on multi-party data. We achieve an accuracy of 47% on determining the actual identity of the referent. All results are achieved without the use of visual information.
Real-time lane detection by using multiple cues

People have a growing interest for driver assistant systems that are used to monitor the driving conditions by visual technique, and warn and guide drivers the road conditions. This paper proposes a real-time lane detection algorithm which is a necessary part for driver assistant system and unmanned vehicle. The algorithm presented in this paper integrates multiple cues, including bar filter which is efficient to detect bar-shape objects like road lane, color cue, and Hough Transform (HT). After obtaining integrated multiple cues we utilize particle filtering technique to realize lane tracking, which guarantees the robust and real-time lane detection. Experimental results show that the algorithm gives a precise and robust detection of lane in various situations.
A Gradient-Based Comparison Measure for Visual analysis of Multifield Data

We introduce a multifield comparison measure for scalar fields that helps in studying relations between them. The comparison measure is insensitive to noise in the scalar fields and to noise in their gradients. Further, it can be computed robustly and efficiently. Results from the visual analysis of various data sets from climate science and combustion applications demonstrate the effective use of the measure.
Multicenter prospective trial of hypofractionated radiation treatment, toceranib, and prednisone for measurable canine mast cell tumors.

BACKGROUND
Mast cell tumors (MCT) are common cutaneous tumors in dogs and when not amenable to surgical excision can present a therapeutic challenge. New treatment protocols for unresectable MCT are needed.


HYPOTHESIS
The combination of toceranib, prednisone, and hypofractionated radiation treatment (RT) will be well tolerated and efficacious.


ANIMALS
Seventeen client-owned dogs with measurable MCT amenable to RT.


METHODS
Prospective clinical trial. All dogs received prednisone, omeprazole, diphenhydramine, and toceranib. Toceranib was administered for 1 week before initiating RT, consisting of 24 Gy delivered in 3 or 4 fractions.


RESULTS
On an intent-to-treat basis, the overall response rate was 76.4%, with 58.8% of dogs achieving a complete response and 17.6% a partial response. The median time to best response was 32 days, and the median progression-free interval was 316 days. The overall median survival time was not reached with a median follow-up of 374 days. The most common toxicoses were gastrointestinal and hepatic.


CONCLUSIONS AND CLINICAL IMPORTANCE
The combination of hypofractionated RT, toceranib, and prednisone was tolerated and efficacious in the majority of dogs. Response rates and durations were higher than those reported for toceranib as a single-agent treatment for MCT. This combination is a viable treatment option for unresectable MCT.
Pareto based artificial bee colony algorithm for multi objective single model assembly line balancing with uncertain task times

Assembly line balancing is significant for efficient and cost effective production of the products and is therefore gaining popularity in recent years. However, several uncertain events in assembly lines might causes variation in the task time and due to these variations there always remains a possibility that completion time of tasks might exceed the predefined cycle time. To hedge against this issue, a single model assembly line balancing problem with uncertain task times and multiple objectives is presented. Current research is aimed to minimize cycle time in addition to maximize the probability that completion time of tasks on stations will not exceed the cycle time and minimize smoothness index simultaneously. A Pareto based artificial bee colony algorithm is proposed to get Pareto solution of the multiple objectives. The proposed algorithm called Pareto based artificial bee colony algorithm (PBABC) introduces some extra steps i.e., sorting of food sources, niche technique and preserve some elitists in the standard artificial bee colony algorithm (ABC) to get Pareto solution. Furthermore, the effective parameters of the proposed algorithm are tuned using Taguchi method. Experiments are performed to solve standard assembly line balancing problems taken from operations research (OR) library. The performance of proposed PBABC algorithm is compared with a famous multi objective optimization algorithm NSGA II, in literature. Computational result shows that proposed PBABC algorithm outperforms NSGA II in terms of the quality of Pareto solutions and computational time. 2014 Elsevier Ltd. All rights reserved.