LLukas22/scidocs huggingface dataset:
IL6-STAT3-HIF signaling and therapeutic response to the angiogenesis inhibitor sunitinib in ovarian clear cell cancer.

PURPOSE
Ovarian clear cell adenocarcinoma (OCCA) is an uncommon histotype that is generally refractory to platinum-based chemotherapy. We analyze here the most comprehensive gene expression and copy number data sets, to date, to identify potential therapeutic targets of OCCA.


EXPERIMENTAL DESIGN
Gene expression and DNA copy number were carried out using primary human OCCA tumor samples, and findings were confirmed by immunohistochemistry on tissue microarrays. Circulating interleukin (IL) 6 levels were measured in serum from patients with OCCA or high-grade serous cancers and related to progression-free and overall survival. Two patients were treated with sunitinib, and their therapeutic responses were measured clinically and by positron emission tomography.


RESULTS
We find specific overexpression of the IL6-STAT3-HIF (interleukin 6-signal transducer and activator of transcription 3-hypoxia induced factor) pathway in OCCA tumors compared with high-grade serous cancers. Expression of PTHLH and high levels of circulating IL6 in OCCA patients may explain the frequent occurrence of hypercalcemia of malignancy and thromboembolic events in OCCA. We describe amplification of several receptor tyrosine kinases, most notably MET, suggesting other potential therapeutic targets. We report sustained clinical and functional imaging responses in two OCCA patients with chemotherapy-resistant disease who were treated with sunitinib, thus showing significant parallels with renal clear cell cancer.


CONCLUSIONS
Our findings highlight important therapeutic targets in OCCA, suggest that more extensive clinical trials with sunitinib in OCCA are warranted, and provide significant impetus to the growing realization that OCCA is molecularly and clinically distinct to other forms of ovarian cancer.
Title : Structural Design of Reinforced Concrete Tall Buildings

Structural Design of Reinforced Concrete Tall Buildings Author: Ali Sherif S. Rizk, Director, Dar al-Handasah Shair & Partners Subject: Structural Engineering
The utility of the microvascular anastomotic coupler in free tissue transfer.

BACKGROUND
The microvascular anastomosis remains a technically sensitive and critical determinant of success in free tissue transfer. The microvascular anastomotic coupling device is an elegant, friction-fit ring pin device that is becoming more widely used.


OBJECTIVE
To systematically review the literature to examine the utility of the microvascular coupler in free tissue transfer.


METHODS
A comprehensive database search was performed to identify eligible publications. Inclusion criteria were anastomotic coupler utilization and free-tissue transfer. Recorded information from eligible studies included patient age, follow-up, radiation history, number of free-flaps and failure rates, reconstruction subsites, number of coupled venous and arterial anastomoses, coupling time, conversion to sutured anastomosis, coupler size and thrombosis rates.


RESULTS
Twenty-five studies reporting on 3207 patients were included in the analysis. A total of 3576 free-flaps were performed within the following subsites: 1103 head and neck, 2094 breast, 300 limb or body, and 79 nonspecified. There were only 26 reported flap failures (0.7%). A total of 3497 venous and 342 arterial coupled anastomoses were performed. The primary outcome measure was thrombosis rates, and there were 61 venous (1.7%) and 12 arterial (3.6%) thromboses reported. Mean coupling time was 5 min, and 30 anastomoses (0.8%) were converted to suture.


CONCLUSION
Flap survival and revision-free application of the microvascular coupler occurred in more than 99% of cases. There is a substantial time savings with coupler use. Venous and arterial thrombosis rates are comparable with the best results achieved by sutured anastomosis and, when used by experienced surgeons, the coupler achieves superior results.
Outdoor directional radio propagation measurements in the V-band

In this paper results of a radio propagation measurement campaign at a centre frequency of 54 GHz and 70 GHz, with 6.0 GHz bandwidth are presented. An in-house built $2\times 2$ MIMO chirp-based channel sounder with standard horn antennas configured to provide simultaneously co and cross-polarized information, was used in the measurements. The receiver antennas were rotated in 5° steps to provide full azimuth spatial angular information. In the paper the results of the estimated path loss, delay spread and azimuth angular spread statistics for a street canyon scenario is presented. Lower delay spread values are observed with the transmitter and receiver antennas facing each other. The mean azimuth angular spread is similar across the two bands for the same polarisation. The path loss coefficient on the co-polarized link was 2.4 and 2.0 for the 54 GHz and 70 GHz respectively.
Data priority based slot allocation for Wireless Body Area Networks

This paper focuses on the slot allocation scheme of MAC protocol to achieve energy-efficiency for the Wireless Body Area Network (WBAN). The WBAN is adopted to realize the wireless communication between the patient and the monitoring station in a healthcare system. The energy of miniature sensor nodes in WBAN is mainly consumed in the wireless interface and MAC protocol. We propose a time division multiple access (TDMA) protocol which takes advantage of the fixed topology of the WBAN. To implement the sensor energy efficiency, a slot allocation scheme is taken into account. Considering the heterogeneity of nodes, we formulate the problem as a Binary Integer Nonlinear Dynamic Programming (BINDP) to setup data priorities to achieve high slot utilization. Two heuristic algorithms are designed to solve the problem. Our results show that the proposed algorithms have the advantages of less energy consumption, higher slot utilization rate, and lower delay of the system.
Essay-Anchor Attentive Multi-Modal Bilinear Pooling for Textbook Question Answering

Textbook Question Answering (TQA) [1] is a newly proposed task to answer arbitrary questions in middle school curricula, which has particular challenges to understand the long essays in additional to the images. Bilinear models [2], [3] are effective at learning high-level associations between questions and images, but are inefficient to handle the long essays. In this paper, we propose an Essay-anchor Attentive Multi-modal Bilinear pooling (EAMB), a novel method to encode the long essays into the joint space of the questions and images. The essay-anchors, embedded from the keywords, represent the essay information in a latent space. We propose a novel network architecture to pay special attention on the keywords in the questions, consequently encoding the essay information into the question features, and thus the joint space with the images. We then use the bilinear models to extract the multi-modal interactions to obtain the answers. EAMB successfully utilizes the redundancy of the pre-trained word embedding space to represent the essay-anchors. This avoids the extra learning difficulties from exploiting large network structures. Quantitative and qualitative experiments show the outperforming effects of EAMB on the TQA dataset.
Hedge Funds : Past , Present , and Future

H edge funds often make headlines because of spectacular losses or spectacular gains. In September 2006, a large hedge fund, Amaranth, reported losses of more than $6 billion apparently incurred in only one month, representing a negative return over that month of roughly 66 percent. Earlier in the year, newspapers focused on the $1.4 billion compensation in 2005 of hedge fund manager Boone Pickens and the 650 percent return that year of his BP Capital Commodity Fund (Anderson, 2006b). The importance of hedge funds in the daily life of financial markets does not make the same headlines, but hedge funds now account for close to half the trading on the New York and London stock exchanges (Anderson, 2006a). Chances are that you personally cannot invest in a hedge fund. Most U.S. investors cannot. Hedge funds are mostly unregulated. These funds can only issue securities privately. Their investors have to be individuals or institutions who meet requirements set out by the Securities and Exchange Commission, ensuring that the investors are knowledgeable and can bear a significant loss. Most likely, however, you personally can invest in mutual funds, which are heavily regulated in how they can invest their funds, how their managers can be paid, how they are governed, how they can charge investors for their services, and so on. The typical mutual fund cannot make the investments that provide the performance of Amaranth or the BP Capital Commodity Fund. The economic function of a hedge fund is exactly the same as the function of a mutual fund. In both cases, fund managers are entrusted with money from
A two-pole Halbach permanent magnet guideway for high temperature superconducting Maglev vehicle

In order to improve the levitation performance of the high temperature superconducting (HTS) magnetic levitation (Maglev) vehicle, a two-pole Halbach array’s permanent magnet guideway (PMG) is proposed, which is called as Halbach PMG. The finite element method (FEM) calculations indicate that Halbach PMG has a wider high-field region than the present PMG of equal PM’s transverse section. The levitation force of bulk HTSCs with the present PMG and Halbach PMG are measured. The results show that at different levitation gaps, the force ratios based on the Halbach PMG are about 2.3 times larger than that on the present PMG, which greatly increases the load capability of the system. Therefore, both the numerical analysis and experimental results have confirmed that the Halbach PMG will further enhance the performance of the vehicle and it is possible to decrease the total numbers of onboard HTSCs, reducing overall costs. So based on the Halbach PMG, we further study the width ratios between HTSCs and PMG for making the better use of the onboard HTSCs. Some preliminary results are given. These results are important for further HTS Maglev vehicle system designs using Halbach PMG. 2007 Elsevier B.V. All rights reserved.
Multi-scale capture of facial geometry and motion

We present a novel multi-scale representation and acquisition method for the animation of high-resolution facial geometry and wrinkles. We first acquire a static scan of the face including reflectance data at the highest possible quality. We then augment a traditional marker-based facial motion-capture system by two synchronized video cameras to track expression wrinkles. The resulting model consists of high-resolution geometry, motion-capture data, and expression wrinkles in 2D parametric form. This combination represents the facial shape and its salient features at multiple scales. During motion synthesis the motion-capture data deforms the high-resolution geometry using a linear shell-based mesh-deformation method. The wrinkle geometry is added to the facial base mesh using nonlinear energy optimization. We present the results of our approach for performance replay as well as for wrinkle editing. CR Categories: I.3.5 [Computer Graphics]: Computational Geometry and Object Modeling—Hierarchy and Geometric Transformations; I.3.7 [Computer Graphics]: Three-Dimensional Graphics and Realism—Animation
On sensitivity of central solutions in semidefinite programming

In this paper we study the properties of the analytic central path of a semide nite programming problem under perturbation of a set of input parameters. Speci cally, we analyze the behavior of solutions on the central path with respect to changes on the right hand side of the constraints, including the limiting behavior when the central optimal solution is approached. Our results are of interest for the sake of numerical analysis, sensitivity analysis and parametric programming. Under the primal-dual Slater condition and the strict complementarity condition we show that the derivatives of central solutions with respect to the right hand side parameters converge as the path tends to the central optimal solution. Moreover, the derivatives are bounded, i.e. a Lipschitz constant exists. This Lipschitz constant can be thought of as a condition number for the semide nite programming problem. It is a generalization of the familiar condition number for linear equation systems and linear programming problems. However, the generalized condition number depends on the right hand side parameters as well, whereas it is well-known that in the linear programming case the condition number depends only on the constraint matrix. We demonstrate that the existence of strictly complementary solutions is important for the Lipschitz constant to exist. Moreover, we give an example in which the set of right hand side parameters for which the strict complementarity condition holds is neither open nor closed. This is remarkable since a similar set for which the primal-dual Slater condition holds is always open.
Rickettsia rickettsii infection of the EA.hy 926 endothelial cell line: morphological response to infection and evidence for oxidative injury.

EA.hy 926 is a permanent human cell line that expresses highly differentiated functions characteristic of human vascular endothelium. Rickettsia rickettsii can efficiently infect and cause a cytopathic effect in EA.hy 926 cells. R. rickettsii produced visible lytic plaques in EA.hy 926 cells at 10 d post-infection (p.i.) following application of a secondary agarose overlay containing 2 micrograms emetine ml-1 and 40 micrograms NaF ml-1 on day 2. Rickettsial growth in EA.hy 926 cells had a similar profile to that occurring in human umbilical vein endothelial cells (HUVEC) and rickettsiae catalysed polymerization of actin tails. Intracellular multiplication of R. rickettsii resulted in significant changes in the internal morphology of EA.hy 926 cells, most notably extensive dilatation of the membranes of the endoplasmic reticulum and outer nuclear envelope by 72 h p.i. These events correlated with significant alterations in the host-cell antioxidant system, including decreased levels of intracellular reduced glutathione and glutathione peroxidase activity and increased amounts of intracellular peroxide through to 96 h of infection. These findings are similar to the changes described previously for R. rickettsii-infected HUVEC and suggest that common mechanisms associated with rickettsia-induced oxidative injury occur in the two cell lines. EA.hy 926 cells were also used to investigate the influence of the antioxidant alpha-lipoic acid on rickettsial infection. Overnight pretreatment with 1-500 microM alpha-lipoic acid did not prevent cells from being destroyed following infection with rickettsiae. Supplementation of the culture medium with 1 and 10 microM alpha-lipoic acid 2 h after rickettsial inoculation also did not provide any protective effect. However, 100, 200 and 500 microM alpha-lipoic acid increased the viability of infected cells at 96 h to 45, 51 and 70%, respectively compared with 26% for untreated, infected samples. Thiol levels and glutathione peroxidase activity in treated, infected cells increased and peroxide content decreased proportionally to increasing alpha-lipoic acid concentrations. Furthermore, treatment with 500 microM alpha-lipoic acid for 72 h p.i. completely prevented ultrastructural changes in infected cells. In conclusion, the permanent endothelial cell line EA.hy 926 is susceptible to injury induced by R. rickettsii infection. Although the cellular changes resulting from infection are not identical in all aspects to that demonstrated previously in HUVEC, the increased reproducibility and convenience of EA.hy 926 cells make them suitable for biochemical and morphological studies.
Long-Term Psychosocial Functioning in Women with Bilateral Prophylactic Mastectomy: Does Preservation of the Nipple-Areolar Complex Make a Difference?

Nipple-sparing prophylactic mastectomy (PM) is an option for women at high-risk for breast cancer, and may offer better cosmetic results than a skin-sparing PM where the nipple-areolar complex (NAC) is removed. However, there may be residual breast cancer risk due to the maintained NAC. It is unclear if sparing the NAC with PM impacts on psychosocial functioning, including cancer-related distress and body image after PM. This was a cross-sectional survey study of women who had undergone bilateral PM (no previous breast cancer) recruited through surgical or cancer genetics clinics. All women completed standardized questionnaires assessing cancer-related distress, anxiety, depression, satisfaction with decision, decision regret, and health-related quality of life related to breast surgery. Outcomes were compared between women with nipple-areola-sparing PM (NAC-PM) and skin-sparing PM (SS-PM). Overall, 137 women completed the study; 53 (39 %) had NAC-PM and 84 (61 %) had SS-PM. The mean age of the study population was 41.5 years [standard deviation (SD) 8.8] and the mean time between PM and questionnaire completion was 50 months (SD 31). On the BREAST-Q, we found that women with NAC-PM had significantly higher levels of satisfaction with breasts (p = 0.01), satisfaction with outcome (p = 0.02), and sexual well-being (p < 0.001) compared with SS-PM. No statistically significant differences in total cancer-related distress (p = 0.89), anxiety (p = 0.86), or depression (p = 0.93) were observed between the two groups. Overall, women with NAC-PM had better body image and sexual functioning compared with women with SS-PM, while both groups had comparable levels of cancer-related distress and perception of breast cancer risk.
Methylphenidate for attention-deficit/hyperactivity disorder in children and adolescents: Cochrane systematic review with meta-analyses and trial sequential analyses of randomised clinical trials

STUDY QUESTION
Is methylphenidate beneficial or harmful for the treatment of attention-deficit/hyperactivity disorder (ADHD) in children and adolescents?


METHODS
Electronic databases were searched up to February 2015 for parallel and crossover randomised clinical trials comparing methylphenidate with placebo or no intervention in children and adolescents with ADHD. Meta-analyses and trial sequential analyses (TSA) were conducted. Quality was assessed using GRADE. Teachers, parents, and observers rated ADHD symptoms and general behaviour.


STUDY ANSWER AND LIMITATIONS
The analyses included 38 parallel group trials (n=5111, median treatment duration 49 days) and 147 crossover trials (n=7134, 14 days). The average age across all studies was 9.7 years. The analysis suggested a beneficial effect of methylphenidate on teacher rated symptoms in 19 parallel group trials (standardised mean difference (SMD) -0.77, n=1698), corresponding to a mean difference of -9.6 points on the ADHD rating scale. There was no evidence that methylphenidate was associated with an increase in serious adverse events (risk ratio 0.98, nine trials, n=1532; TSA adjusted intervention effect RR 0.91). Methylphenidate was associated with an increased risk of non-serious adverse events (1.29, 21 trials, n=3132; TSA adjusted RR 1.29). Teacher rated general behaviour seemed to improve with methylphenidate (SMD -0.87, five trials, n=668) A change of 7 points on the child health questionnaire (CHQ) has been deemed a minimal clinically relevant difference. The change reported in a meta-analysis of three trials corresponds to a mean difference of 8.0 points on the CHQ (range 0-100 points), which suggests that methylphenidate may improve parent reported quality of life (SMD 0.61, three trials, n=514). 96.8% of trials were considered high risk of bias trials according to the Cochrane guidelines. All outcomes were assessed very low quality according to GRADE.


WHAT THIS STUDY ADDS
The results suggest that among children and adolescents with a diagnosis of ADHD, methylphenidate may improve teacher reported symptoms of ADHD and general behaviour and parent reported quality of life. However, given the risk of bias in the included studies, and the very low quality of outcomes, the magnitude of the effects is uncertain. Methylphenidate is associated with an increased risk of non-serious but not serious adverse events.


FUNDING, COMPETING INTERESTS, DATA SHARING
Region Zealand Research Foundation and Copenhagen Trial Unit. Competing interests are given in the full paper on bmj.com. Full data are available in the version of this review published in The Cochrane Library.
Time distortion associated with smartphone addiction: Identifying smartphone addiction via a mobile application (App).

BACKGROUND
Global smartphone penetration has brought about unprecedented addictive behaviors.


AIMS
We report a proposed diagnostic criteria and the designing of a mobile application (App) to identify smartphone addiction.


METHOD
We used a novel empirical mode decomposition (EMD) to delineate the trend in smartphone use over one month.


RESULTS
The daily use count and the trend of this frequency are associated with smartphone addiction. We quantify excessive use by daily use duration and frequency, as well as the relationship between the tolerance symptoms and the trend for the median duration of a use epoch. The psychiatrists' assisted self-reporting use time is significant lower than and the recorded total smartphone use time via the App and the degree of underestimation was positively correlated with actual smartphone use.


CONCLUSIONS
Our study suggests the identification of smartphone addiction by diagnostic interview and via the App-generated parameters with EMD analysis.
3D Virtual worlds and the metaverse: Current status and future possibilities

Moving from a set of independent virtual worlds to an integrated network of 3D virtual worlds or Metaverse rests on progress in four areas: immersive realism, ubiquity of access and identity, interoperability, and scalability. For each area, the current status and needed developments in order to achieve a functional Metaverse are described. Factors that support the formation of a viable Metaverse, such as institutional and popular interest and ongoing improvements in hardware performance, and factors that constrain the achievement of this goal, including limits in computational methods and unrealized collaboration among virtual world stakeholders and developers, are also considered.
Scientific workflow design for mere mortals

Recent years have seen a dramatic increase in research and development of scientific workflow systems. These systems promise to make scientists more productive by automating data-driven and computeintensive analyses. Despite many early achievements, the long-term success of scientific workflow technology critically depends on making these systems useable by ‘‘mere mortals’’, i.e., scientists who have a very good idea of the analysis methods they wish to assemble, but who are neither software developers nor scripting-language experts. With these users in mind, we identify a set of desiderata for scientific workflow systems crucial for enabling scientists to model and design the workflows they wish to automate themselves. As a first step towards meeting these requirements, we also show how the collection-oriented modeling and design (comad) approach for scientific workflows, implemented within the Kepler system, can help provide these critical, design-oriented capabilities to scientists. © 2008 Elsevier B.V. All rights reserved.