LLukas22/scidocs huggingface dataset:
Turning the Tides: Coping with Trauma and Addiction through Residential Adolescent Group Therapy.

TOPIC
Evidence-based group therapy in an inpatient setting that provides an integrated treatment approach for both trauma and addiction in female adolescents.


PURPOSE
The purpose of this evidence-based practice (EBP) project was to implement and assess the impact of an integrated group therapy approach for both posttraumatic stress disorder (PTSD) and substance use disorder (SUD) in adolescent females as part of a residential treatment program.


SOURCES
The Iowa Model of EBP guided this EBP project. Judith Herman's three-stage model of trauma recovery and the Skills Training in Affective and Interpersonal Regulation (STAIR) model served as the theoretical framework for the group therapy curriculum. Two programs, Seeking Safety, by Lisa Najavits and VOICES, by Stephanie Covington, provided a guide for group topics and activities.


CONCLUSIONS
Patients that participated in Turning the Tides© group therapy curriculum reported a decrease in overall PTSD symptoms and decreased functional impairment scores, based on the Child PTSD Symptoms Scale. However, there was a statistically significant increase in the use of as needed medications following the completion of group therapy. Postgroup evaluations from patients indicated a genuine desire to engage in the group therapy as well as an increased sense of trust with facilitators. Implications for psychiatric nursing include the delivery of safe, quality patient care as evidenced by positive improvement in patient outcomes.
Cross-cultural validation of the Leeds sleep evaluation questionnaire (LSEQ) in insomnia patients.

The Leeds sleep evaluation questionnaire (LSEQ) is a standardized self-reporting instrument comprising ten 100 mm visual analogue scales that pertain to the ease of getting to sleep (GTS), quality of sleep (QOS), ease of awakening from sleep (AFS) and alertness and behaviour following wakefulness (BFW). Although the LSEQ has been used in a variety of populations, published psychometric data on insomnia patients are limited. The LSEQ reliability and construct validity was evaluated in 396 French insomnia patients aged 55 years and over, who were treated with placebo (2 weeks) and melatonin (3 weeks). The results supported LSEQ internal consistency, reliability and construct validity with minor differences from those of the original English version. Then the internal consistency of the LSEQ was evaluated in 257 insomnia patients (age 20-80 years) in France and Israel who, following a 1 week placebo baseline, were randomized to placebo or melatonin treatment for 3 weeks. Cronbach's alpha and Pearson's r correlation coefficients for placebo and drug treatment conditions (p<0.001 for all) supported LSEQ internal consistency in different treatment and age groups and in different languages. It is concluded that the consistency, reliability and validity of the four LSEQ domains allows them to be singled out as independent outcome variables in cross cultural sleep research and clinical practice in adult and elderly patients with insomnia.
AHA Scientific Statement Acute Heart Failure Syndromes : Emergency Department Presentation , Treatment , and Disposition : Current Approaches and Future Aims

Copyright © 2010 American Heart Association. All rights reserved. Print ISSN: 0009-7322. Online 72514 Circulation is published by the American Heart Association. 7272 Greenville Avenue, Dallas, TX DOI: 10.1161/CIR.0b013e3181f9a223 published online Oct 11, 2010; Circulation Care, Perioperative and Resuscitation Critical Association Council on Clinical Cardiology and Council on Cardiopulmonary, Parshall, Gary S. Francis, Mihai Gheorghiade and on behalf of the American Heart Anderson, Cynthia Arslanian-Engoren, W. Brian Gibler, James K. McCord, Mark B. Neal L. Weintraub, Sean P. Collins, Peter S. Pang, Phillip D. Levy, Allen S. Statement From the American Heart Association Treatment, and Disposition: Current Approaches and Future Aims. A Scientific Acute Heart Failure Syndromes: Emergency Department Presentation, http://circ.ahajournals.org located on the World Wide Web at: The online version of this article, along with updated information and services, is
The Population of the Lake Taupo Region, New Zealand, 1839-1859

Early historical estimates of population size, missionary census records, and other documentary evidence indicate that the population of the Lake Tau po region was of the order of llOO to 1600 in the mid-nineteenth century.
Clevudine demonstrates potent antiviral activity in naïve chronic hepatitis B patients.

OBJECTIVES
Clevudine has demonstrated antiviral potency in the treatment of naïve chronic hepatitis B patients in pivotal studies. The objectives of this study were to evaluate the safety and efficacy of a 1-year treatment with clevudine in chronic hepatitis B patients.


METHODS
This is a post-marketing surveillance using case report forms which were submitted to the health authorities.


RESULTS
Analysis of individual data showed that hepatitis B virus (HBV) DNA after a 1-year treatment was <141,500 copies/ml in 96% of hepatitis B e antigen (HBeAg)-positive and 100% of HBeAg-negative patients. The proportion of patients with HBV DNA <2,000 copies/ml after a 1-year treatment was 74%: 71% of HBeAg-positive and 93% of HBeAg-negative patients. Most of the patients with HBV DNA below the detection limit with each assay at week 24 showed sustained viral suppression up to week 48. The proportion of patients who showed normal alanine aminotransferase at week 48 was 86% in HBeAg-positive patients and 87% in HBeAg-negative patients. The rates of HBeAg-loss were 21%. Two patients showed viral breakthrough during treatment.


CONCLUSION
Clevudine monotherapy demonstrates potent antiviral activity as well as biochemical and serological response with a 0.7% rate of viral breakthrough in naïve chronic hepatitis B patients.
Role of salivary anti-SSA/B antibodies for diagnosing 
primary Sjögren’s syndrome

UNLABELLED
The diagnosis of primary Sjögren's syndrome (pSS) is complex, and the saliva test is a potential method to improve the existing diagnostic criteria.


OBJECTIVE
To estimate the diagnostic accuracy of salivary anti-SSA/B antibodies in primary Sjögren's syndrome (pSS), and to analyze their correlations with clinical and laboratory profiles.


STUDY DESIGN
This study enrolled 100 pSS patients and 140 non-pSS controls, including 40 rheumatoid arthritis (RA) patients, 40 systemic lupus erythematosus (SLE) patients, and 60 healthy controls. Unstimulated whole saliva and stimulated parotid saliva samples were collected from the subjects. Salivary anti-SSA/B antibodies were measured using an enzyme-linked immunosorbent assay (ELISA). Clinical and laboratory data were retrieved from the medical records.


RESULTS
In the pSS group, the sensitivity of anti-SSA and anti-SSB antibodies in whole saliva was 49% and 29%, respectively, and the specificity was 87.5% and 95%. The sensitivity of anti-SSA and anti-SSB antibodies in parotid saliva was 32% and 8%, respectively, and the specificity was 95.52% and 97.86%, respectively. In the pSS group, the diagnostic accuracy of anti-SSA/B antibodies in whole saliva was significantly higher than in parotid saliva (p<0.05), but was significantly lower than in serum (p<0.05). The salivary flow rate in the pSS group positive for whole salivary anti-SSA was significantly lower than in the negative group (p<0.05). The prevalence of rheumatoid factor and antinuclear factor were significantly higher in salivary SSB-positive pSS patients than in SSB-negative patients (p<0.05).


CONCLUSIONS
Compared to parotid saliva, whole saliva is a more suitable diagnostic fluid. Using salivary anti-SSA/B antibodies as a single test item is insufficient given the relatively low sensitivity. Further studies should investigate the possibility of combining tests for different salivary autoantibodies as a method for diagnosing pSS.
Off-treatment virologic relapse and outcomes of re-treatment in chronic hepatitis B patients who achieved complete viral suppression with oral nucleos(t)ide analogs

BACKGROUND
The durability of off-treatment virologic responses has not been fully elucidated in chronic hepatitis B (CHB) patients who have previously achieved complete virologic suppression with nucleos(t)ide analog (NA) therapy. This study aimed to assess off-treatment virologic relapse rates and to characterize the outcomes of subsequent re-treatment in CHB patients who have discontinued oral NA following complete virologic suppression.


METHODS
Ninety-five CHB patients who showed complete virologic suppression were withdrawn from NAs: entecavir, lamivudine, and clevudine in 67, 15, and 13 patients, respectively. Consolidation therapy was given for 6 and 12 months for HBeAg-positive and -negative CHB, respectively, before cessation. Virologic relapse was managed with the same NA that had induced complete virologic response before discontinuation.


RESULTS
The cumulative rates of virologic relapse at 12 and 24 months were 73.8% and 87.1%, respectively. The relapse rates were independent of HBeAg positivity, HBeAg seroconversion, and type of oral NA. In a multivariate analysis, duration of oral NA therapy was the only significant predicting factor associated with off-treatment virologic relapse. Although the majority of patients regained complete virologic suppression, some patients did not respond to re-treatment with the initial NA and developed genotypic resistance.


CONCLUSIONS
NA consolidation therapy for 6 and 12 months is associated with high off-treatment virologic relapse in HBeAg-positive and -negative CHB patients, respectively. Drugs with high genetic barriers to resistance should be considered as a rescue therapy for off-treatment relapse in CHB.
Giant cell arteritis and polymyalgia rheumatica: usefulness of vascular magnetic resonance imaging studies in the diagnosis of aortitis.

OBJECTIVES
One of the unresolved challenges posed in giant cell (temporal) arteritis (GCA) is the detection and monitoring of large-artery complications, particularly aortitis. Recent investigations support vascular magnetic resonance imaging (MRI) studies in this issue. We report our preliminary experience with this imaging technique in the study of the aorta and its proximal branches in patients with GCA and/or polymyalgia rheumatica (PMR).


METHODS
Between 2000 and 2003, six patients with GCA and/or PMR seen in our department were diagnosed with aortitis using vascular MRI studies. In all cases, the study was performed according to a specifically designed protocol that included MRI and MR angiography (MRA).


RESULTS
MRI was a hepful non-invasive method for diagnosis of aortitis in all cases, providing accurate information about its extent. In particular, MRI had a higher ability to detect earlier stages of vasculitis disclosing subclinical aortitis in five of the six patients. The main signs of early vascular inflammation observed were vessel wall thickness and oedema (six cases) and increased mural enhancement on postcontrast T1-weighted images (four cases). MRA disclosed lumen changes (stenosis) in two patients. On follow-up studies, whereas vascular stenosis and vessel wall thickness remained invariable, vascular wall oedema and contrast enhancement improved significantly when disease activity decreased.


CONCLUSION
MRI may be a useful technique for diagnosing patients with occult major artery involvement in GCA, whether presenting with classic symptoms of temporal arteritis or PMR. Its utility for monitoring the course of the disease and response to treatment requires further confirmation.
Mining a Sub-Matrix of Maximal Sum

Biclustering techniques have been widely used to identify homogeneous subgroups within large data matrices, such as subsets of genes similarly expressed across subsets of patients. Mining a max-sum sub-matrix is a related but distinct problem for which one looks for a (non-necessarily contiguous) rectangular sub-matrix with a maximal sum of its entries. Le Van et al. [6] already illustrated its applicability to gene expression analysis and addressed it with a constraint programming (CP) approach combined with large neighborhood search (CP-LNS). In this work, we exhibit some key properties of this NP-hard problem and define a bounding function such that larger problems can be solved in reasonable time. Two different algorithms are proposed in order to exploit the highlighted characteristics of the problem: a CP approach with a global constraint (CPGC) and mixed integer linear programming (MILP). Practical experiments conducted both on synthetic and real gene expression data exhibit the characteristics of these approaches and their relative benefits over the original CP-LNS method. Overall, the CPGC approach tends to be the fastest to produce a good solution. Yet, the MILP formulation is arguably the easiest to formulate and can also be competitive.
European Collaborative Study Defining Clinical Profile Outcomes and Novel Prognostic Criteria in Monoclonal Immunoglobulin M-Related Light Chain Amyloidosis.

PURPOSE
Immunoglobulin M (IgM)-related light chain (AL) amyloidosis, which accounts for 6% to 10% of all AL amyloidosis cases, is a rare and poorly studied clinical entity. Its natural history and management is not clearly defined. Prognostic and response criteria for AL amyloidosis in general have not been validated in this population.


PATIENTS AND METHODS
We retrospectively gathered data for 250 patients diagnosed with IgM AL amyloidosis from three European amyloidosis centers. Clinical features, hematologic response, and overall survival (OS) were analyzed. The current staging and response criteria in non-IgM AL amyloidosis was applied to this series to assess its utility in this patient cohort.


RESULTS
Patients with IgM AL amyloidosis have a significant IgM paraprotein (median, 10 g/L), less frequent lambda light chain isotype, and evaluable difference between involved and uninvolved free light chains (dFLCs; > 50 mg/L) in only two thirds of patients. Bone marrow showed clear non-Hodgkin lymphoma as the underlying disorder in 54% of patients. Cardiac involvement (45%) is less common but there is more frequent lymph node (20%) and neuropathic (28%) involvement compared with non-IgM AL. Fifty-seven percent of patients achieved a hematologic response (14% very good partial response/complete response [VGPR/CR]), with median OS not reached for patients achieving VGPR/CR, 64 months for PR, and 28 months for nonresponders (P < .001). On multivariate analysis, cardiac involvement, advanced Mayo disease stage, neuropathic involvement, and liver involvement were independent factors that had an impact on survival. Combining abnormal N-terminal pro-brain natriuretic peptide (NT-proBNP) and troponin T with liver involvement and the presence of neuropathy gives a better risk model: median OS of patients with none, one, or two or more abnormal factors was 90, 33, and 16 months, respectively.


CONCLUSION
IgM AL amyloidosis is a distinct clinical entity. Low-risk disease can be defined by combining cardiac involvement with novel prognostic markers. Deeper hematologic responses translate into improved outcomes, yet deep responses remain dismally poor, which highlights the urgent need for novel therapies.
Prehospital endotracheal intubation: elemental or detrimental?

This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2015 and co-published as a series in Critical Care. Other articles in the series can be found online at http://ccforum.com/series/annualupdate2015. Further information about the Annual Update in Intensive Care and Emergency Medicine is available from http://www.springer.com/series/8901.
Three-Level Resonant Converter With Double $LLC$  Resonant Tanks for High-Input-Voltage Applications

A new resonant converter having low voltage stress and nearly constant efficiency against line variation for high- and wide-input-voltage applications is presented in this paper. It is similar to a three-level zero-voltage-switching pulsewidth modulation converter (TL ZVS PWMC) with two flying capacitors. In the proposed converter, however, two flying capacitors are used as the resonant capacitors, and the output voltage regulation is achieved by frequency modulation. The main advantages of the proposed converter are that, since the sum of the voltages of two resonant capacitors is constant and is equal to half of the input voltage, the voltage across each switch clamps to half of the input voltage and keeps the balance. Moreover, all main switches and rectifier diodes are softly switched under full-line and full-load conditions, and high efficiency can be constantly achieved over a wide input voltage range. These advantages solve the drawbacks on TL ZVS PWMCs. The features, operation principles, and relevant analysis results over a wide input voltage range of the proposed converter are presented in this paper. The validity of this study is confirmed by the experimental results of a prototype converter with 400-600-V input, 48-V/10-A output, and 200-kHz resonant frequency. The experimental results show that the maximum efficiency of the proposed converter is 95.08% under a full-load and a 600-V input and slightly varies across the 400-600-V input voltage range.
Evaluation of Status of Cadmium, Lead, and Nickel Levels in Biological Samples of Normal and Night Blindness Children of Age Groups 3–7 and 8–12 Years

The causes of night blindness in children are multifactorial, and particular consideration has been given to childhood trace metals toxicity, which is the most common problem found in underdeveloped countries. This study was designed to compare the levels of cadmium (Cd), lead (Pb), and nickel (Ni) in scalp hair, blood, and urine of night blindness children age ranged 3–7 and 8–12 years of both genders, comparing them to sex- and age-matched controls. A microwave-assisted wet acid digestion procedure was developed as a sample pretreatment, for the determination of Cd, Pb, and Ni in biological samples of night blindness children. The proposed method was validated by using conventional wet digestion and certified reference samples of hair, blood, and urine. The digests of all biological samples were analyzed for Cd, Pb, and Ni by electrothermal atomic absorption spectrometry. The results indicated significantly higher levels of Cd, Pb, and Ni in the biological samples (blood, scalp hair, and urine) of male and female night blindness children, compared with control subjects of both genders. These data present guidance to clinicians and other professional investigating toxicity of trace metals in biological samples of night blindness children.
Screening for the detection of impaired fasting glucose, impaired glucose tolerance and type 2 diabetes in welfare homes residents from south-eastern region of Poland.

To the Editor: This response (1) confirms that many chiropractors find it impossible to accept the key messages regarding spinal manipulation therapy (SMT), namely that this therapy lacks a plausible rationale (2) and its risks outweigh its benefits (3). The risks are, of course, far greater than the relatively few deaths seem to imply. Several hundred cases of severe but non-fatal adverse events are on record (e.g. 4,5). The benefits of SMT have, so far, not been demonstrated; even the many chiropractors who criticised my review (6–12), have not produced convincing evidence for such benefit. Why? The answer is simple: there is none! In the most recent Cochrane review of SMT for chronic low back pain, the main indication for chiropractors, concluded that ‘there is no clinically relevant difference between SMT and other interventions for reducing pain’ (13). For all other conditions, the evidence is even more squarely negative (14). If we focus on the bigger picture, we are confronted with balancing little benefit with considerable risks. The result of such an evaluation can never be positive – no matter how we turn and twist the complex details of this debate. Prof. E. Ernst Director, Complementary Medicine, Peninsula Medical School, University of Exeter, 25 Victoria Park Road, Exeter, EX2 4NT, UK Email: edzard.ernst@pms.ac.uk
Protective Coatings on Metals. Number 3, 1970 (Selected Articles),

Abstract : ;Contents: The surface alloying of the alloy ZhS6K using three elements; Certain results derived from testing and study of compacted heat-resistant coatings; The structure and properties of heat-resistant alloys with vacuum diffusion coatings.
Impact of Data and Task Characteristics on Design of Spatio-Temporal Data Visualization Tools

It is widely recognized that data visualization may be a powerful methodology for exploratory analysis. In order to fulfill this claim, visualization software must be carefully designed taking into account two principal aspects: characteristics of the data to be visualized and the exploratory tasks to be supported. The tasks that may potentially arise in data exploration are, in their turn, dependent on the data. In the chapter, we present visualization software tools for three different types of spatio-temporal data developed using a task-driven approach to design. We demonstrate that different exploratory tasks may be anticipated in these three cases and that different techniques are required to properly support exploration of the data. Prior to the consideration of the examples, we briefly describe the typologies of data and tasks we use in our work. 10.1 Scope and Perspective This chapter offers a view on geovisualization from the perspective of computer scientists with an extensive experience in developing software tools for exploratory analysis of spatial data. Our tools are mostly based on combination of familiar techniques from various disciplines: Cartography, Statistical Graphics, Information Visualization, and Human–Computer Interaction. Traditional mapping and graphing techniques are enhanced with interactivity and manipulability. Typically, the ideas concerning useful technique combinations and enhancements come to us when we examine some specific datasets received from people interested in exploring these data. It is commonly recognized that techniques used for graphical representation of data must correspond to characteristics of the data (Bertin, 1983), and the same applies to software tools for visual data exploration. However, as we have learned from our Exploring Geovisualization J. Dykes, A.M. MacEachren, M.-J. Kraak (Editors) q 2005 Elsevier Ltd. All rights reserved. 201 preprint : November 2004 do not redistribute. J. Dykes, A.M. MacEachren, M-J. Kraak (2005), Exploring Geovisualization, Pergamon, 732pp. 0-08-044531-4 experience, the route from data characteristics to the development of appropriate tools consists of two parts: first, data characteristics determine the potential questions (tasks) that may emerge in the process of the data exploration; second, the tasks make requirements of the tools and thereby define the space of possible design options. In this chapter, we advocate the task – analytical approach to the selection of appropriate visualization techniques and design of tools for the exploratory analysis of geographically referenced data. For this purpose, we offer three examples of geovisualization tool design for different types of spatio-temporal data. Prior to the consideration of the examples, we introduce the typological framework we use for revealing the set of potential tasks from the characteristics of datasets to analyze. We hope this material will be useful both for designers of geovisualization tools and for analysts applying existing tools to their data.