LLukas22/scidocs huggingface dataset:
His595Tyr polymorphism in the methionine synthase reductase (MTRR) gene is associated with pancreatic cancer risk.

BACKGROUND & AIMS
This study attempts to elucidate a part of the genetic predisposition to the sporadic invasive ductal adenocarcinoma of the pancreas focusing on the genes implicated in the gene-environment interactions in carcinogenesis.


METHODS
First, 227 single nucleotide polymorphisms (SNPs) of 46 genes were genotyped on 198 cases and 182 controls. The SNPs, which showed a significant association, were further genotyped on additional samples to perform a joint analysis (total 317 cases vs 1232 controls). The gene selected by joint analysis was resequenced for a high-density SNP typing and a haplotype analysis on 702 cases and 785 controls. Function of the risk and wild-type haplotypes was assessed using cells transfected with complementary DNA (cDNA).


RESULTS
The joint analysis with multiple testing adjustment identified 2 SNPs on the methionine synthase reductase (MTRR) gene: rs162049 (intronic SNP), Fisher exact test, P = .0018; OR, 1.33; 95% CI: 1.11-1.60 and rs10380 (His595Tyr), Fisher exact test, P = .0063; OR, 1.45; 95% CI: 1.11-1.88. The SNPs remained significant in the recessive model after the permutation test for multiple testing (rs162049, P = .024; rs10380, P = .023) in the high-density analysis. Stable transfectants of the risk haplotype MTRR cDNA showed significantly elevated homocysteine levels in a culture medium, a lower level of the LINE-1 methylation, and a lower expression of the MTRR protein than did the transfectants with the wild-type haplotype cDNA.


CONCLUSIONS
Our study suggested a common missense SNP of the MTRR gene as a novel pancreatic cancer susceptibility factor with a functional significance in folate-related metabolism and the genome-wide methylation status.
Efficacy of pacing therapies for treating atrial tachyarrhythmias in patients with ventricular arrhythmias receiving a dual-chamber implantable cardioverter defibrillator.

BACKGROUND
Although overdrive pacing for treating atrial flutter is well established, the efficacy of device-based atrial pacing for treating spontaneous atrial tachyarrhythmias in patients with implantable cardioverter defibrillators (ICD) is unknown. This study evaluated the efficacy of novel pacing therapies for treating atrial tachyarrhythmias in patients receiving a dual-chamber ICD to treat ventricular tachyarrhythmias.


METHODS AND RESULTS
A Jewel AF ICD was implanted in 537 patients with ventricular arrhythmia who were followed for 11.4+/-8.2 months (74% had a documented history of atrial tachyarrhythmias). The device discriminated atrial tachycardia (AT) from atrial fibrillation (AF) on the basis of cycle length and regularity, and it used 3 different methods of overdrive atrial pacing (Ramp, Burst+, and 50-Hz burst) to treat AT episodes and one method (50-Hz burst) to treat AF episodes. Pacing successfully terminated 59% of 1500 spontaneous AT episodes in 127 patients and 30% of 880 AF episodes in 101 patients (P<0.001). With AT and AF episodes combined, pacing efficacy was 48%. Pacing efficacy was significantly reduced at AT cycle lengths </=220 ms and AF cycle lengths </=160 ms (P<0.01) The median time from pacing to AT/AF termination was 1.1 minute for the pacing successes and 96 minutes for the failures (P<0.001).


CONCLUSIONS
Atrial pacing terminated 48% of AT/AF episodes in patients with a history of ventricular arrhythmias. Pacing efficacy was greater for device-classified AT than AF. Pacing efficacy was significantly influenced by tachycardia cycle length. Successful pacing significantly reduces the time required for AT/AF termination.
The Effects of Wal-Mart on Local Labor Markets

What effect does Wal-Mart, the world’s largest retailer, have on local retail employment and earnings in the United States? In this lecture, Professor David Neumark will show that a WalMart store opening reduces county-level retail employment by about 150 workers. This implies that each Wal-Mart worker replaces about 1.4 retail workers and, on average, generates a 2.7 per cent reduction in average retail employment. The results also show that a Wal-Mart store leads to a decline in county-level retail earnings of about $1.2 million, or a 1.3 per cent average reduction at the county-level. Given that there is rising retail employment in the US, the presence of Wal-Mart does not necessarily imply higher unemployment, but does imply there is likely to be lower retail employment growth at a county level in the presence of Wal-Mart stores. ANU COLLEGE OF BUSINESS & ECONOMICS, CRAWFORD SCHOOL OF ECONOMICS & GOVERNMENT AND ANU COLLEGE OF ASIA & THE PACIFIC PRESENT:
Why Do Part-Time Workers Earn Less? The Role of Worker and Job Skills

Part-time workers receive considerably lower hourly earnings than do fulltime workers. Using Current Population Survey earnings files for September 1995 through December 2002, the author finds that measurable worker and job characteristics, including occupational skill requirements, account for much of the part-time penalty. Longitudinal analysis of the data indicates that much of the remaining gap reflects worker heterogeneity, evidenced by small wage gains and losses among workers switching between part-time and full-time jobs. The lower skills of part-time than full-time workers result primarily from limited work experience and accumulation of human capital. Little evidence can be found of a large wage gap between part-time and full-time women. A part-time wage penalty is found for men, but men account for less than one-third of total part-time employment.
Effect of Taurine Supplements on Fat Absorption in Cystic Fibrosis

ABSTRACT: Patients with cystic fibrosis have an increased proportion of glycine conjugated bile acids with diminished tauroconjugates which could contribute to fat malabsorption. Twenty-two CF children with documented steatorrhea were supplemented with taurine capsules (30 mg/kg/day) and placebo during separate 6-month treatment periods. Alteration of the glycine/taurine conjugation pattern was verified in two patients who showed a predominance of tauroconjugates as a result of taurine supplementation. On taurine, steatorrhea was reduced (p < 0.05) by 17.6 ± 9.7% in 19 patients who completed the study as was the excretion of long-chain saturated fatty acids. There was no change in linoleic acid (C 18:2) excretion. In the 10 patients with a more severe degree of steatorrhea the decrease in fat loss approached 20% and a close relationship was found (r = 0.84, p < 0.01) between the extent of the fatty acid loss on placebo and the decrease of this loss on taurine. A linear relationship was found between the percentage decrease of individual fatty acids and their log solubility in water. No change was found in the daily excretion of bile acids, neutral sterols, and nitrogen. Fasting plasma fatty acids, cholesterol, and triglycerides were also unchanged. Monitoring of growth over the two 6-month periods revealed a marginal (p < 0.1) increase of weight velocity expressed as a percentage expected for age (83.4 ± 11.3 → 117.1 ± 16.5). The increase in height velocity in response to taurine showed a more modest trend (95.3 ± 7.8 → 110.7 ± 10.6). These data provide some support for the use of taurine supplements as an adjuvant form of therapy, particularly in patients with a more severe degree of steatorrhea. Additional clinical testing is warranted before recommending its general use.
Safety and Immunogenicity of H1/IC31®, an Adjuvanted TB Subunit Vaccine, in HIV-Infected Adults with CD4+ Lymphocyte Counts Greater than 350 cells/mm3: A Phase II, Multi-Centre, Double-Blind, Randomized, Placebo-Controlled Trial

BACKGROUND
Novel tuberculosis vaccines should be safe, immunogenic, and effective in various population groups, including HIV-infected individuals. In this phase II multi-centre, double-blind, placebo-controlled trial, the safety and immunogenicity of the novel H1/IC31 vaccine, a fusion protein of Ag85B-ESAT-6 (H1) formulated with the adjuvant IC31, was evaluated in HIV-infected adults.


METHODS
HIV-infected adults with CD4+ T cell counts >350/mm3 and without evidence of active tuberculosis were enrolled and followed until day 182. H1/IC31 vaccine or placebo was randomly allocated in a 5:1 ratio. The vaccine was administered intramuscularly at day 0 and 56. Safety assessment was based on medical history, clinical examinations, and blood and urine testing. Immunogenicity was determined by a short-term whole blood intracellular cytokine staining assay.


RESULTS
47 of the 48 randomised participants completed both vaccinations. In total, 459 mild or moderate and 2 severe adverse events were reported. There were three serious adverse events in two vaccinees classified as not related to the investigational product. Local injection site reactions were more common in H1/IC31 versus placebo recipients (65.0% vs. 12.5%, p = 0.015). Solicited systemic and unsolicited adverse events were similar by study arm. The baseline CD4+ T cell count and HIV viral load were similar by study arm and remained constant over time. The H1/IC31 vaccine induced a persistent Th1-immune response with predominately TNF-α and IL-2 co-expressing CD4+ T cells, as well as polyfunctional IFN-γ, TNF-α and IL-2 expressing CD4+ T cells.


CONCLUSION
H1/IC31 was well tolerated and safe in HIV-infected adults with a CD4+ Lymphocyte count greater than 350 cells/mm3. The vaccine did not have an effect on CD4+ T cell count or HIV-1 viral load. H1/IC31 induced a specific and durable Th1 immune response.


TRIAL REGISTRATION
Pan African Clinical Trials Registry (PACTR) PACTR201105000289276.
Intelligent UUVs: Some issues on ROV dynamic positioning

Intelligent unmanned underwater vehicles (UUVs) fall under two main group categories: the remotely operated vehicles (ROVs), which are characterized by remote operation and presence of a tether cable; and the autonomous underwater vehicles (AUVs), which are characterized by their autonomous behavior and absence of a tether cable. One fundamental issue of the UUV design is the dynamic position control system. This system plays a crucial role together with the sensor architecture in the degree of system autonomy that can be achieved. This paper is concerned with a few issues when dynamically positioning remotely operated underwater vehicles (ROVs). By restricting the operating regime of ROVs to slow velocity requirements the paper investigates the implementation of a few decentralized control strategies and compare their performance measures, which are assessed by simulating a nonlinear ROV system model for each control strategy. Issues concerning input tracking, disturbance rejection, and plant variations are discussed. The evaluations consider the use of linear PID feedback and feedforward variants, and a robust nonlinear control strategies applied to a full order, fully coupled, and nonlinear vehicle model. These evaluations consider a vehicle undertaking standard mission activities where the tether cable dynamics, with load estimates obtained from a lumped mass cable model, and the vehicle actuator system are present. The paper shows that much of the performance deterioration may be attributed mainly due to cable inertia. The authors also verify that the nonlinear robust control strategy does not necessarily allow for better performance over the linear feedback control strategies implemented when vehicle motions are confined to slow velocity profiles. These and other partial results will aid the design of the control system for an underwater vehicle currently under construction
Partial discharge monitoring for power transformer using UHF sensors. Part 2: field experience

Because of the large capital value of power transformers and their critical role in the electricity network, there is an increasing need for non-intrusive diagnostic and monitoring tools to assess their internal condition. The UHF technique is being applied increasingly to monitor partial discharges (PD) in power transformers and has been shown to be much more sensitive than acoustic techniques when the signal path passes through solid insulation. Field trials were performed on five power transformers ranging in size from 18 to 1000 MVA and in voltage from 25 to 400 kV. The results of PD tests on power transformers provide sufficient evidence to justify making provision for UHF sensors on new transformers to facilitate their monitoring when required during the service lifetime.
Combining cycles of the Canadian Community Health Survey.

BACKGROUND
A single cycle of the Canadian Community Health Survey (CCHS) may not meet researchers' analytical needs. This article presents methods of combining CCHS cycles and discusses issues to consider if these data are to be combined. An empirical example illustrates the proposed methods.


DATA AND METHODS
Two methods can be used to combine CCHS cycles: the separate approach and the pooled approach. With the separate approach, estimates are calculated for each cycle separately and then combined. The pooled approach combines data at the micro-data level, and the resulting dataset is treated as if it is a sample from one population.


RESULTS
For the separate approach, it is recommended that the simple average of the estimates be used. For the pooled approach, it is recommended that weights be scaled by a constant factor where a period estimate covering the time periods of the individual cycles can be created. The choice of method depends on the aim of the analysis and the availability of data.


INTERPRETATION
Combining cycles should be considered only if the most current period estimates do not suffice. Both methods will obscure cycle-to-cycle trends and will not reveal changing behaviours related to public health initiatives.
Treatment of gustatory hyperlacrimation (crocodile tears) with injection of botulinum toxin into the lacrimal gland

Purpose To establish the efficacy and safety of botulinum toxin in the treatment of Crocodile Tear Syndrome and record any possible complications.Methods Four patients with unilateral aberrant VII cranial nerve regeneration following an episode of facial paralysis consented to be included in this study after a comprehensive explanation of the procedure and possible complications was given. On average, an injection of 20 units of botulinum toxin type A (Dysport®) was given to the affected lacrimal gland. The effect was assessed with a Schirmer’s test during taste stimulation. Careful recording of the duration of the effect and the presence of any local or systemic complications was made.Results All patients reported a partial or complete disappearance of the reflex hyperlacrimation following treatment. Schirmer’s tests during taste stimulation documented a significant decrease in tear secretion. The onset of effect of the botulinum toxin was typically 24–48 h after the initial injection and lasted 4–5 months. One patient had a mild increase in his preexisting upper lid ptosis, but no other local or systemic side effects were experienced.Conclusions The injection of botulinum toxin type A into the affected lacrimal glands of patients with gusto-lacrimal reflex is a simple, effective and safe treatment.
Permutation Search Methods are Efficient, Yet Faster Search is Possible

We survey permutation-based methods for approximate knearest neighbor search. In these methods, every data point is represented by a ranked list of pivots sorted by the distance to this point. Such ranked lists are called permutations. The underpinning assumption is that, for both metric and non-metric spaces, the distance between permutations is a good proxy for the distance between original points. Thus, it should be possible to efficiently retrieve most true nearest neighbors by examining only a tiny subset of data points whose permutations are similar to the permutation of a query. We further test this assumption by carrying out an extensive experimental evaluation where permutation methods are pitted against state-of-the art benchmarks (the multi-probe LSH, the VP-tree, and proximity-graph based retrieval) on a variety of realistically large data set from the image and textual domain. The focus is on the highaccuracy retrieval methods for generic spaces. Additionally, we assume that both data and indices are stored in main memory. We find permutation methods to be reasonably efficient and describe a setup where these methods are most useful. To ease reproducibility, we make our software and data sets publicly available.
Coparenting among lesbian, gay, and heterosexual couples: associations with adopted children's outcomes.

Coparenting is associated with child behavior in families with heterosexual parents, but less is known about coparenting among lesbian- and gay-parent families. Associations were studied among self-reported divisions of labor, coparenting observations, and child adjustment (Mage  = 3 years) among 104 adoptive families headed by lesbian, gay, or heterosexual couples. Lesbian and gay couples reported sharing child care, whereas heterosexual couples reported specialization (i.e., mothers did more child care than fathers). Observations confirmed this pattern-lesbian and gay parents participated more equally than heterosexual parents during family interaction. Lesbian couples showed the most supportive and least undermining behavior, whereas gay couples showed the least supportive behavior, and heterosexual couples the most undermining behavior. Overall, supportive coparenting was associated with better child adjustment.
Novel High Step-Up DC–DC Converter for Fuel Cell Energy Conversion System

A novel high step-up dc-dc converter for fuel cell energy conversion is presented in this paper. The proposed converter utilizes a multiwinding coupled inductor and a voltage doubler to achieve high step-up voltage gain. The voltage on the active switch is clamped, and the energy stored in the leakage inductor is recycled. Therefore, the voltage stress on the active switch is reduced, and the conversion efficiency is improved. Finally, a 750-W laboratory prototype converter supplied by a proton exchange membrane fuel cell power source and an output voltage of 400 V is implemented. The experimental results verify the performances, including high voltage gain, high conversion efficiency, and the effective suppression of the voltage stress on power devices. The proposed high step-up converter can feasibly be used for low-input-voltage fuel cell power conversion applications.
Extracting Pre-ordering Rules from Predicate-Argument Structures

Word ordering remains as an essential problem for translating between languages with substantial structural differences, such as SOV and SVO languages. In this paper, we propose to automatically extract pre-ordering rules from predicateargument structures. A pre-ordering rule records the relative position mapping of a predicate word and its argument phrases from the source language side to the target language side. We propose 1) a lineartime algorithm to extract the pre-ordering rules from word-aligned HPSG-tree-tostring pairs and 2) a bottom-up algorithm to apply the extracted rules to HPSG trees to yield target language style source sentences. Experimental results are reported for large-scale English-to-Japanese translation, showing significant improvements of BLEU score compared with the baseline SMT systems.
Tip shaping in primary rhinoplasty: an algorithmic approach.

BACKGROUND
Underprojection and lack of tip definition often coexist. Techniques that improve both nasal tip refinement and projection are closely interrelated, and an algorithmic approach can be developed to improve the predictability of the dynamic changes that occur. Use of nondestructive and nonpalpable techniques that enhance nasal tip shape are emphasized.


METHODS
A retrospective review of primary rhinoplasty patients was undertaken to delineate the precise role of preoperative analysis, intraoperative evaluation, and execution of specific surgical techniques in creating nasal tip refinement and projection. Specific case studies are used to demonstrate the efficacy and predictability of these maneuvers.


RESULTS
Successful tip refinement and projection depends on (1) proper preoperative analysis of the deformity; (2) a fundamental understanding of the intricate and dynamic relationships between tip-supporting structures that contribute to nasal tip shape and projection; and (3) execution of the operative plan using controlled, nondestructive, and predictable surgical techniques.


CONCLUSIONS
A simplified algorithmic approach to creating aesthetic nasal tip shape and projection in primary rhinoplasty has been established to aid the rhinoplasty surgeon in reducing the inherent unpredictability of combined techniques and improving long-term aesthetic outcomes.
Cyclophosphamide, vincristine, and prednisone followed by tositumomab and iodine-131-tositumomab in patients with untreated low-grade follicular lymphoma: eight-year follow-up of a multicenter phase II study.

PURPOSE
The efficacy and safety of cyclophosphamide, vincristine, and prednisone (CVP) followed by tositumomab and iodine-131 ((131)I) -tositumomab therapy were evaluated in a multicenter phase II study in patients with untreated low-grade follicular lymphoma.


PATIENTS AND METHODS
Patients received six cycles of CVP followed by one cycle of tositumomab and (131)I-tositumomab (one dosimetric dose and one therapeutic dose). The treatment was evaluated for efficacy and safety.


RESULTS
All 30 patients enrolled completed CVP as well as tositumomab and (131)I-tositumomab therapy. The overall response rate after completion of therapy was 100%, with 28 patients (93%) achieving a complete response (CR) and two patients achieving a partial response. Of the 17 patients with bone marrow involvement at enrollment, 15 achieved a confirmed CR. Fourteen of 15 patients with bulky disease (> or = 5 cm) had a CR after treatment completion. After a median follow-up of 8.4 years, the median response duration had not been reached (range, 3 to 111+ months). Five-year progression-free and overall survival rates were 56% and 83%, respectively. The most common grade > or = 3 hematologic adverse events were neutropenia (87%) and thrombocytopenia (37%). Nineteen patients received growth factor support, and three required blood product transfusions. No patients developed human antimurine antibodies. Two patients developed myelodysplastic syndrome/acute myeloid leukemia.


CONCLUSION
These mature data demonstrate that sequential therapy with a non-anthracycline-containing regimen comprising CVP followed by one cycle of tositumomab and (131)I-tositumomab produced high response rates with adequate safety and durable remissions and that this regimen represents a highly active treatment for first-line therapy of follicular non-Hodgkin's lymphoma.