LLukas22/scidocs huggingface dataset:
Involvement in bullying and suicidal ideation in middle adolescence: a 2-year follow-up study

The objective of the study was to ascertain whether involvement in bullying increases the risk for subsequent suicidal ideation. A total of 2,070 Finnish girls and boys aged 15 were surveyed in the ninth grade (age 15) in schools, and followed up 2 years later in the Adolescent Mental Health Cohort Study. Involvement in bullying was elicited at age 15 by two questions focusing on being a bully and being a victim of bullying. Suicidal ideation was elicited by one item of the short Beck Depression Inventory at age 17. Baseline depressive symptoms and externalizing symptoms, age and sex were controlled for. Statistical analyses were carried out using cross-tabulations with Chi-square/Fisher’s exact test and logistic regression. Suicidal ideation at age 17 was 3–4 times more prevalent among those who had been involved in bullying at age 15 than among those not involved. Suicidal ideation at age 17 was most prevalent among former victims of bullying. Being a victim of bullying at age 15 continued to predict subsequent suicidal ideation when depressive and externalizing symptoms were controlled for. Being a bully at age 15 also persisted as borderline significantly predictive of suicidal ideation when baseline symptoms were controlled for. Findings indicate adolescent victims and perpetrators of bullying alike are at long-term risk for suicidal ideation.
Comparison of the prognostic value of cardiopulmonary exercise testing between male and female patients with heart failure.

BACKGROUND
Cardiopulmonary exercise testing (CPX) clearly holds prognostic value in the heart failure (HF) population. Studies investigating the prognostic value of CPX in individuals with HF have consistently examined predominantly male groups. The purpose of the present study was to examine the prognostic value of CPX in a female HF group.


METHODS
Seventy-five female and 337 male subjects diagnosed with HF participated in this study. The ability of peak oxygen consumption (VO(2)) and the minute ventilation/carbon dioxide production (VE/VCO(2)) slope to predict cardiac-related events were assessed.


RESULTS
In the year following CPX, the female group suffered 26 cardiac-related events (8 deaths/18 hospitalizations), while the male group suffered 89 cardiac-related events (20 deaths/69 hospitalizations). The hazard ratios for peak VO(2) and the VE/VCO(2) slope were 4.0 (95% confidence interval: 2.6-6.1, p<0.001) and 4.2 (95% confidence interval: 2.7-6.6, p<0.001) in the male group and 3.8 (95% confidence interval: 1.7-8.5, p<0.001) and 4.3 (95% confidence interval: 1.8-9.8, p<0.001) in the female group. In both the male and female groups, Cox multivariate analysis revealed VE/VCO(2) slope was the strongest predictor of cardiac-related events while peak VO(2) added significant predictive value and was retained in the regression.


CONCLUSION
The results of the present study indicate that the prognostic value of peak VO(2) and the VE/VCO(2) slope are similar in men and women diagnosed with HF. In both men and women, the prognostic power of the VE/VCO(2) slope is greater than that of peak VO(2).
Integrating talent and knowledge management: Where are the benefits?

Purpose – The purpose of this paper is to examine how the principles of talent management (TM) can be leveraged to enhance an organization’s knowledge management (KM) initiatives. Design/methodology/approach – This paper critically reviews the literature pertaining to the emerging concept of TM and specifically that which focuses on ‘‘smart talent management’’ i.e. the fusion of TM and KM concepts. The authors offer insights as to how TM can benefit KM and then discuss these insights with a focus group of KM practitioners. Findings – The fusion of the two concepts has so far only been considered by human resource scholars who have tended to examine how learnings from the field of KM can be leveraged to advance TM. The authors confront the issue in reverse and identify five KM concerns – identifying key knowledge workers, knowledge creation, knowledge sharing, developing knowledge competencies, and knowledge retention – which they argue can be advanced through the application of TM principles. Their focus group confirms that these KM concerns can benefit from the integration of TM principles, but some more than others. Originality/value – The fusion of TM and KM has so far only been considered from a HR perspective. This paper examines the fusion of the two concepts from a KM perspective. Five specific KM concerns which can benefit from the integration of a TM approach are detailed and then validated by a focus group of KM practitioners.
An active analog delay and the delay reference loop

Wireline signal processing circuits such as transversal equalizers rely on true time delay. An active analog delay stage is proposed that requires a sixteenth of the area of a comparable LC delay line. A delay reference loop is also presented to tune the delay stage against process, voltage, and temperature variations. A reference signal is introduced to tune the delay. The impact of non-idealities must be considered, to understand the relationship between the reference frequency and the locked time delay. A SiGe BiCMOS implementation of the active analog delay stage and delay reference loop is presented that operates to 10 Gb/s.
The effect of injecting botulinum toxin type a into the calf muscles on freezing of gait in Parkinson's disease: a double blind placebo-controlled pilot study.

OBJECTIVE
To assess the effect on freezing of gait (FOG) of botulinum toxin type A (BTX-A) injections in advanced Parkinson's disease (PD) patients.


METHOD
BTX-A 150 IU or normal saline was injected into each leg's calf muscles by a blinded investigator. FOG severity was assessed at set intervals (6-month follow-up).


RESULTS
Eleven age- and disease severity-matched PD patients with disabling FOG participated. Six patients received BTX-A and 5 received saline. No improvement was observed in either group over time. Leg weakness and falls lead to early termination.


CONCLUSION
BTX-A injections to the legs did not improve FOG and might increase fall risk.
Advanced Flooding Attack on a SIP Server

Voice over IP is gaining more popularity in today's communications. The Session Initiation Protocol (SIP) is the most popular VoIP signalling protocol is vulnerable to many kinds of attacks. Among all these attack, flood-based denial of service attacks have been identified as the biggest threat to SIP. Even though a great deal of research has been conducted into mitigating denial of service attacks, only a small proportion have been specific to SIP. This paper examines how denial of service attacks affect the performance of a SIP-based system, and proposes an Improved Security-Enhanced SIP System (ISESS) to mitigate such attacks. Experimental results are provided to demonstrate the effectiveness of ISESS. The experimental results show that with ISESS, during a flood-based denial of service attack, the performance of the system can be improved substantially.
Sustained function of alginate-encapsulated human islet cell implants in the peritoneal cavity of mice leading to a pilot study in a type 1 diabetic patient

Alginate-encapsulated human islet cell grafts have not been able to correct diabetes in humans, whereas free grafts have. This study examined in immunodeficient mice whether alginate-encapsulated graft function was inferior to that of free grafts of the same size and composition. Cultured human islet cells were equally distributed over free and alginate-encapsulated grafts before implantation in, respectively, the kidney capsule and the peritoneal cavity of non-obese diabetic mice with severe combined immunodeficiency and alloxan-induced diabetes. Implants were followed for in vivo function and retrieved for analysis of cellular composition (all) and insulin secretory responsiveness (capsules). Free implants with low beta cell purity (19 ± 1%) were non-functional and underwent 90% beta cell loss. At medium purity (50 ± 1%), they were functional at post-transplant week 1, evolving to normoglycaemia (4/8) or to C-peptide negativity (4/8) depending on the degree of beta cell-specific losses. Encapsulated implants immediately and sustainably corrected diabetes, irrespective of beta cell purity (16/16). Most capsules were retrievable as single units, enriched in endocrine cells that exhibited rapid secretory responses to glucose and glucagon. Single capsules with similar properties were also retrieved from a type 1 diabetic recipient at post-transplant month 3. However, the vast majority were clustered and contained debris, explaining the poor rise in plasma C-peptide. In immunodeficient mice, i.p. implanted alginate-encapsulated human islet cells exhibited a better outcome than free implants under the kidney capsule. They did not show primary non-function at low beta cell purity and avoided beta cell-specific losses by rapidly establishing normoglycaemia. Retrieved capsules presented secretory responses to glucose, which was also observed in a type 1 diabetic recipient. Trial registration: ClinicalTrials.gov NCT01379729 Funding: This study was supported by grants from the JDRF (centre grant 4-2005-1327), the Research Foundation Flanders (G.0801.10), the 6th and 7th Framework Program of the European Commission (numbers 512145 and 241883), and the Agency for Innovation by Science and Technology in Flanders (IWT-TBM7 090884).
Cybercrime: Understanding and addressing the concerns of stakeholders

Cybercrime and cybercriminal activities continue to impact communities as the steady growth of electronic information systems enables more online business. The collective views of sixty-six computer users and organizations, that have an exposure to cybercrime, were analyzed using concept analysis and mapping techniques in order to identify the major issues and areas of concern, and provide useful advice. The findings of the study show that a range of computing stakeholders have genuine concerns about the frequency of information security breaches and malware incursions (including the emergence of dangerous security and detection avoiding malware), the need for e-security awareness and education, the roles played by law and law enforcement, and the installation of current security software and systems. While not necessarily criminal in nature, some stakeholders also expressed deep concerns over the use of computers for cyberbullying, particularly where younger and school aged users are involved. The government’s future directions and recommendations for the technical and administrative management of cybercriminal activity were generally observed to be consistent with stakeholder concerns, with some users also taking practical steps to reduce cybercrime risks. a 2011 Elsevier Ltd. All rights reserved.
Epidemiological and prognostic factors involved in upper gastrointestinal bleeding: results of a French prospective multicenter study.

BACKGROUND AND STUDY AIMS
The mortality rate from upper gastrointestinal bleeding (UGIB) remains high, at 5 % - 10 %. The aim of the current study was to describe the epidemiological characteristics, prognostic factors, and actual practice in a cohort of patients with UGIB admitted to French general hospitals.


METHODS
From March 2005 to February 2006, a prospective multicenter study was conducted at 53 French hospitals. A total of 3298 patients admitted for UGIB were enrolled consecutively. Patient data were collected up to the date of discharge from hospital.


RESULTS
Data were available for 2130 men and 1073 women (mean age 63 ± 18 years), one-third of whom were taking drugs that would increase the risk of UGIB. The two main causes of bleeding were peptic ulcers (38 %) and esophagogastric varices (EGV) or portal hypertensive gastropathy (24.5 %). Mean Rockall score was 5.0 ± 2.3. Endoscopy was performed on 96 % of patients (within 24 hours in 79 %), and 66 % of those with ulcers and 62.5 % of the EGV patients underwent hemostatic therapy when indicated. Rebleeding occurred in 9.9 % of the patients, and 8.3 % died. Independent predictors of rebleeding were: need for transfusion (odds ratio [OR] 19.1; 95 % confidence interval [95 %CI] 10.1 - 35.9); hemoglobin < 10 g/dL (OR: 1.7; 95 %CI 1.1 - 3.3); Rockall score (OR: 1.4 for each 1 point score increase; 95 %CI 1.0 - 1.9), systolic blood pressure < 100 mmHg (OR: 1.9; 95 %CI 1.4 - 2.5), and signs of recent bleeding (OR: 2.4; 95 %CI 1.7 - 3.5). Independent predictors of mortality were: Rockall score (OR: 2.8; 95 %CI 2.0 - 4.0), co-morbidities (OR: 3.6 for each additional co-morbidity; 95 %CI 2.0 - 6.3), and systolic blood pressure < 100 mmHg (OR: 2.1; 95 %CI 1.8 - 2.8). Rockall score, blood pressure and co-morbidities were taken as continuous variables meaning that the OR was 1.4 for every point increase, it was the same for blood pressure.


CONCLUSION
UGIB still occurs mainly as a result of peptic ulcers and portal hypertension in France, and causes significant rates of mortality. There is scope for improvement via better prevention (better use of UGIB-facilitating drugs), endoscopic therapy, and management of co-morbidities.
Banana peel: A novel substrate for cellulase production under solid-state fermentation

The feasibility of using banana peel for the production of cellulase by Trichoderma viride GIM 3.0010 in solid-state fermentation was evaluated in this study. The effect of incubation time, incubation temperature, initial moisture content of the medium, inoculum size and supplementation of carbon sources and nitrogen sources on cellulase production was investigated. When banana peel was moistened to the moisture content of 65% with the inoculum size of 1.5 × 10 9 spores / flask and incubated at 30°C for 144 h, the maximum activities of filter paper activity (FPA), carboxy methyl cellulase sodium activity (CMCase) and β-glucosidase (BG) reached 5.56, 10.31 and 3.01 U/gds, respectively. These results indicated that banana peel provided necessary nutrients for cell growth and cellulase synthesis. It can be used as a potential substrate for cellulase production by T. viride GIM 3.0010 under solid-state fermentation. To the best of our knowledge, this is the first report on cellulase production using banana peel.
Radiation therapy and chemotherapy-induced oral mucositis.

UNLABELLED
Increasing the intensity of radiation therapy and chemotherapy in the management of cancer has increased the incidence of adverse effects, especially oral mucositis.


AIM AND METHODS
a bibliographical review was conducted on the definition of oral mucositis, its clinical findings, the incidence, its etiology, the pathophysiology, associated morbidity, prevention and treatment.


RESULTS
current studies define oral mucositis as a very frequent and painful inflammation with ulcers on the oral mucosa that are covered by a pseudo membrane. The incidence and severity of lesions are influenced by patient and treatment variables. Oral mucositis is a result of two major mechanisms: direct toxicity on the mucosa and myelosuppression due to the treatment. Its pathophysiology is composed of four interdependent phases: an initial inflammatory/vascular phase; an epithelial phase; an ulcerative/bacteriological phase; and a healing phase. It is considered a potential source of life-threatening infection and often is a dose-limiting factor in anticancer therapy. Some interventions have been shown to be potentially effective to prevent and treat oral mucositis. Further intensive research through well-structured clinical trials to obtain the best scientific evidence over the standard therapy of oral mucositis is necessary to attain ideal parameters for radiotherapy and chemotherapy.
Optimal base complexes for quadrilateral meshes

In this paper we give an explicit algorithm to optimize the global structure of quadrilateral meshes i.e base complexes, using a graph perfect matching. The approach consists of constructing a special graph over the singularity set of the mesh and finding all quadrilateral based complex subgraphs of that graph. We show by construction that there is always an optimal base complex to a given quadrilateral mesh relative to coarseness versus geometry awareness. Local structures of the mesh induce extra constraints which have been previously ignored but can give a completely different layout. These are diagonal, multiple and close to zero length edges. We give an efficient solution to solve these problems and improve the computation speed. Generally all base complex optimization schemes are bounded by the topology of the singularities, we explore the space of layouts encoded in the graph to identify removable singularities of the mesh while simultaneously optimize the base complex. This is the author’s version. The final version is published at CAGD elsevier (GMP2017).
In vivo reflectance confocal microscopy of equivocal melanocytic lesions detected by digital dermoscopy follow-up.

BACKGROUND
Digital follow-up is a useful method for the detection of melanoma in atypical mole syndrome patients. The combination of digital follow-up (DFU) and reflectance confocal microscopy (RCM) could be useful to increase the accuracy in the classification of equivocal lesions in atypical mole syndrome patients.


OBJECTIVES
To assess the impact of RCM analysis on sensitivity and specificity of digital follow-up in a high-risk melanoma setting.


METHODS
Retrospective study with dermoscopy and RCM of consecutive equivocal atypical melanocytic lesions exhibiting changes in digital dermoscopy in a referral centre.


RESULTS
Sixty-four lesions from 51 patients were included. Thirteen changing lesions (20.3%) corresponded to eight melanomas in situ and five invasive melanomas with Breslow less than 1 mm. Fifty-one lesions corresponded to melanocytic naevus with variable atypia. Total dermoscopy scores were not different between naevus and melanoma neither in the baseline (mean 5.06 and 5.24; P = 0.37) nor in the follow-up dermoscopic control (mean 5.44 and 5.55; P = 0.37). The only significant dermoscopic feature associated with melanoma in multivariate analysis was the presence of streaks after follow-up (P = 0.027; OR = 3.6; CI 1.50-8.70). The confocal microscopy evaluation (by means both the Modena and Barcelona methods) showed a sensitivity and specificity for the diagnosis of melanoma of 100% and 69% respectively. Based on our experience, the combination of RCM and DFU could have avoided 35 of 51 nevi excised.


CONCLUSIONS
Reflectance confocal microscopy evaluation of equivocal lesions detected by DFU improved the accuracy in the detection of melanoma. The combination of dermoscopy, DFU and confocal microscopy in equivocal lesions can be useful to dramatically reduce the number of excisions of benign lesions in atypical mole syndrome patients.
Rheumatic heart disease and pregnancy in Nigerian women.

Summary: The early onset of rheumatic fever and rapid progression to severe and incapacitating chronic valve disease, as in other developing tropical countries, has been repeatedly highlighted in Nigeria. Of interest is the fact that the peak frequency of age distribution is in the early child-bearing age. This study was undertaken to evaluate the clinical course of 44 pregnancies in 32 Nigerian women between 16 and 38 years of age (mean 27), with rheumatic heart disease. The patients received careful clinical assessment on follow-up at 1 to 4 week intervals depending on grade of symptoms and stage of gestation. All deliveries were conducted in the hospital and patients were clinically reassessed 6 months after delivery. The key to grading of symptoms was the New York Heart Association functional classification, coordinated with findings on detailed clinical examination. The majority of the cases were gravida 3 but closely followed by primigravidae. Mitral valve disease with dominant incompetence was the commonest valve lesion. Nevertheless, acute pulmonary edema (11 cases), the cause in 2 of the 3 maternal deaths, was the most frequent complication. Congestive heart failure occurred in 7 cases, and infective endocarditis in 4 cases. The only patient with mitral valve prosthesis was on warfarin prophylaxis and had 2 of the 3 stillbirths in the series. On clinical reassessment 6 months later, there was evidence of progression of functional state in 8, and interestingly, more maternal deaths occurred in less than a year. These findings are no doubt related to the presently limited medical facilities, inadequate socioeconomic and public health standards, and the need for health education in the country, and not excluding the seemingly rapid progression of rheumatic heart disease itself. In light of such circumstances, the relevant aspects of the accepted program of management in the more developed temperate countries would need to be meaningfully adjusted and suggestions have been made to this effect.
Comparative study related to cardiovascular safety between bupivacaine (S75-R25) and ropivacaine in brachial plexus block.

BACKGROUND AND OBJECTIVES
Bupivacaine is a first choice for regional anesthesia considering its effectiveness, long duration and less motor blockade. Bupivacaine (S75-R25) is a mixture of optical isomers containing 75% levobupivacaine (S-) and 25% dextrobupivacaine (R+) created by a Brazilian pharmaceutical company. This investigation compared cardiac safety and efficacy of bupivacaine S75-R25 with vasoconstrictor and ropivacaine for brachial plexus blockade.


METHODS
Patients were randomized to receive brachial plexus anesthesia with either bupivacaine S75-R25 with epinephrine 1:200,000 (bupi) or ropivacaine (ropi), both at 0.50%, in 30 mL solution. We registered a continuous Holter ECG throughout the procedure, as well as the Lovett scale of force in addition to monitoring (heart rate, pulse oximetry and non-invasive blood pressure). The incidence of adverse events was compared with the chi-square or Fisher test.


RESULTS
We allocated forty-four patients into two groups. They did not show any difference related to age, weight or height, gender, as well as for surgical duration. Supraventricular arrhythmias were not different before or after the plexus blockade, independent of the local anesthetic chosen. Loss of sensitivity was faster for the bupivacaine group (23.1 ± 11.7 min) compared to the ropivacaine one (26.8 ± 11.5 min), though not significant (p = 0.205, Student t). There was a reduction in the cardiac rate, observed during the twenty-four-hour Holter monitoring.


CONCLUSIONS
This study showed similar efficacy between bupivacaine S75-R25 for brachial plexus blockade and ropivacaine, with similar incidences of supraventricular arrhythmias.
Wind speed prediction using support vector regression

In this paper the wind speed forecasting in a wind farm, applying the algorithm of support vector regression (SVR) to the mean 10-minute time series is presented. By comparing its performance with an back propagation neural network model through simulation results, we could find following facts: firstly, both algorithms are applicable for prediction the wind speed time series in future; secondly, the prediction effect of support vector regression outperforms the back propagation neural network model as indicated by the prediction graph and by the mean square errors and mean absolute errors. Finally, we selected three different stages of the wind speed curve to analyze, the results show that the proposed algorithm fit the original wind speed curve well at the whole process, but the back propagation neural network is inapplicability for the rise stage when the ascent rate suddenly become flatness of the original wind speed curve.