LLukas22/scidocs huggingface dataset:
Carbon dioxide in petrogenesis III: role of volatiles in the ascent of alkaline magma with special reference to xenolith-bearing mafic lavas

Kinetic and fluid dynamic constraints on deepseated magma migration rates suggest ascent velocities in the range 10 to 30 m/s, 10 -1 to 10m/s and 10 -2 to 5m/s for kimberlitic, garnet peridotite-bearing and spinel peridotite-bearing alkalic magmas. These rates virtually demand translithospheric magma transport by a fracture as opposed to diapiric mechanism. The hypothesis that volatile exsolution accelerates magma through the deep lithosphere is tested by solution of the appropriate set of conservation, mass balance and volatile component solubility equations governing the steady ascent (decompression) of compressible, two-phase magma (melt+ H20 + CO2) in which irreversible phenomena (friction, heat transfer) are accounted for. The results of the numerical experiments were designed to test the importance of melt bulk composition (kimberlite, nephelinite, alkali basalt), initial conditions (mass flux (~/), heat transfer coefficient (B), lumped friction factor (C f)), conduit width (D), initial magma volatile content and geothermal gradients. The fractional increase in ascent rate (A u/ul) is rarely greater than approximately 2 during translithospheric migration. The propellant hypothesis is rejected as a first-order mechanism driving magma acceleration during ascent. The most influential parameters governing ascent dynamics are ~ r CI ' D, B and the geotherm. Because of the relatively incompressible nature of the magmatic volatile phase at P > 100 MPa, the initial magma volatile content plays a secondary (although demonstrable) role. The main role of volatiles is in controlling the initial magma flux (~/) and the magma pressure during ascent. In adiabatic (B=0) simulations, magma ascends nearly isothermally. Generally, however, the assumption of adiabaticity is a poor one especially for flow through narrow (0.5 to 2 m) conduits in old (cold) lithosphere at rates ~ 10-1 m/s. The proposed fluid dynamic model is consistent with and complementary to the magma-driven crack propagation models. The generation of mantle metasomatic fluid is a corollary of the non-adiabatic ascent of volatile-bearing magma through the lithosphere. Magma heat death is an important process for the creation of mantle heterogeneity.
Urethral prolapse after durasphere injection

Urethral prolapse is an uncommon condition among adult patients. We report a case of adult female patient with urethral prolapse after Durasphere injection. The patient was successfully treated with excision of the prolapsed urethra and Durasphere mass, and fibrin glue injection to support the remaining part of urethra.
Capsule endoscopy versus colonoscopy for the detection of polyps and cancer.

BACKGROUND
An ingestible capsule consisting of an endoscope equipped with a video camera at both ends was designed to explore the colon. This study compared capsule endoscopy with optical colonoscopy for the detection of colorectal polyps and cancer.


METHODS
We performed a prospective, multicenter study comparing capsule endoscopy with optical colonoscopy (the standard for comparison) in a cohort of patients with known or suspected colonic disease for the detection of colorectal polyps or cancer. Patients underwent an adapted colon preparation, and colon cleanliness was graded from poor to excellent. We computed the sensitivity and specificity of capsule endoscopy for polyps, advanced adenoma, and cancer.


RESULTS
A total of 328 patients (mean age, 58.6 years) were included in the study. The capsule was excreted within 10 hours after ingestion and before the end of the lifetime of the battery in 92.8% of the patients. The sensitivity and specificity of capsule endoscopy for detecting polyps that were 6 mm in size or bigger were 64% (95% confidence interval [CI], 59 to 72) and 84% (95% CI, 81 to 87), respectively, and for detecting advanced adenoma, the sensitivity and specificity were 73% (95% CI, 61 to 83) and 79% (95% CI, 77 to 81), respectively. Of 19 cancers detected by colonoscopy, 14 were detected by capsule endoscopy (sensitivity, 74%; 95% CI, 52 to 88). For all lesions, the sensitivity of capsule endoscopy was higher in patients with good or excellent colon cleanliness than in those with fair or poor colon cleanliness. Mild-to-moderate adverse events were reported in 26 patients (7.9%) and were mostly related to the colon preparation.


CONCLUSIONS
The use of capsule endoscopy of the colon allows visualization of the colonic mucosa in most patients, but its sensitivity for detecting colonic lesions is low as compared with the use of optical colonoscopy. (ClinicalTrials.gov number, NCT00604162.)
DrugBank: a comprehensive resource for in silico drug discovery and exploration

DrugBank is a unique bioinformatics/cheminformatics resource that combines detailed drug (i.e. chemical) data with comprehensive drug target (i.e. protein) information. The database contains >4100 drug entries including >800 FDA approved small molecule and biotech drugs as well as >3200 experimental drugs. Additionally, >14,000 protein or drug target sequences are linked to these drug entries. Each DrugCard entry contains >80 data fields with half of the information being devoted to drug/chemical data and the other half devoted to drug target or protein data. Many data fields are hyperlinked to other databases (KEGG, PubChem, ChEBI, PDB, Swiss-Prot and GenBank) and a variety of structure viewing applets. The database is fully searchable supporting extensive text, sequence, chemical structure and relational query searches. Potential applications of DrugBank include in silico drug target discovery, drug design, drug docking or screening, drug metabolism prediction, drug interaction prediction and general pharmaceutical education. DrugBank is available at http://redpoll.pharmacy.ualberta.ca/drugbank/.
Treatment of persistent shoulder pain with sodium hyaluronate: a randomized, controlled trial. A multicenter study.

BACKGROUND
Presently, there are no approved nonoperative therapies for the ongoing treatment of persistent shoulder pain. Preliminary data suggest that intra-articular sodium hyaluronate injections may be beneficial for the treatment of persistent shoulder pain resulting from various etiologies. The present study evaluated the efficacy and safety of sodium hyaluronate (Hyalgan; molecular weight, 500 to 730 kDa) for these patients.


METHODS
Six hundred and sixty patients with persistent shoulder pain and limitation resulting from glenohumeral joint osteoarthritis, rotator cuff tear, and/or adhesive capsulitis who had had a failure of conventional therapy were enrolled in this double-blind, randomized, phosphate-buffered saline solution-controlled study, and 456 patients completed twenty-six weeks of follow-up. Patients were randomized to receive either five weekly intra-articular injections of sodium hyaluronate, three weekly intra-articular injections of sodium hyaluronate followed by two weekly intra-articular injections of saline solution, or five weekly intra-articular injections of saline solution. The main outcomes were improvement in terms of shoulder pain on movement at thirteen weeks after the initiation of treatment (as assessed with use of a 100-mm visual analog scale) and the treatment effect throughout twenty-six weeks.


RESULTS
For the overall intent-to-treat population, patients who were managed with sodium hyaluronate had greater pain relief than controls did; significant differences were noted at Week 7 (for the five-injection hyaluronate group), Week 17 (for the three and five-injection hyaluronate groups), and Week 26 (for the three-injection hyaluronate group). Analysis of the stratified populations clearly established that this effect was due to benefits experienced by the patients with osteoarthritis. The treatment effect through twenty-six weeks was significant in patients with osteoarthritis in the three-injection (p = 0.003) and five-injection (p = 0.002) groups, with no significant difference for either regimen in patients without osteoarthritis. The safety profile was very favorable, with no product-related serious adverse effects and no between-group differences for any reported adverse event.


CONCLUSIONS
Although the primary end point of this study (that is, improvement in terms of shoulder pain at thirteen weeks) was not achieved, the overall findings, including secondary end points, indicate that sodium hyaluronate (500 to 730 kDa) is effective and well tolerated for the treatment of osteoarthritis and persistent shoulder pain that is refractory to other standard nonoperative interventions.
The Patient's Anastrozole Compliance to Therapy (PACT) Program: a randomized, in-practice study on the impact of a standardized information program on persistence and compliance to adjuvant endocrine therapy in postmenopausal women with early breast cancer.

BACKGROUND
Compliance and persistence are often overlooked in adjuvant breast cancer treatment.


PATIENTS AND METHODS
PACT was a prospective, multicenter, randomized, open, parallel-group study assessing whether educational materials (EMs) enhanced compliance with aromatase inhibitor (AI) therapy in postmenopausal women with early, hormone-receptor-positive (HR+) breast cancer. The primary end points were compliance (proportion taking ≥ 80% anastrozole) at 12 months and persistence (proportion reporting anastrozole intake during the study period).


RESULTS
Four thousand eight hundred and forty-four patients were randomly assigned 1:1 to receive standard therapy or standard therapy with EMs. There was no difference between arms in compliance (N = 2740; 88.5%/88.8%, respectively, P = 0.81) or persistence rates (N = 2740; 40.5%/43.0%, respectively, P = 0.18). Modified end point analyses found no differences in compliance between arms based on the classification of: (i) patients with missing documentation or follow-up visit <9 months as non-compliant (N = 4397, P = 0.15); (ii) patients with early (≤ 292 days) 12-month follow-up documentation excluded (N = 4091, P = 0.19); (iii) patients reaching ≥ 80% compliance during individual follow-up as compliant (N = 4397, P = 0.26). Modified persistence analyses found no difference between arms (N = 4397, P = 0.37).


CONCLUSIONS
Addition of EMs to standard therapy did not significantly affect compliance and persistence with adjuvant anastrozole. CLINICALTRIALS ID: NCT00555867.
Predation by Orius insidiosus (Heteroptera: Anthocoridae) on Life Stages and Species of Frankliniella Flower Thrips (Thysanoptera: Thripidae) in Pepper Flowers

We compared predation of Orius insidiosus (Say) on adult and second instars of Frankliniella occidentalis (Pergande) andon adults ofF. occidentalis andF. tritici (Fitch) in arenaswith pepper ßowers. Also, we compared the dispersal of these thrips in the presence and absence of the predator. For each experiment, two densities of thrips (10 and 20 total thrips) and two time exposures (10 and 34 h) were tested. Second instars were more likely to move from the ßower where they were released than were F. occidentalis adults. F. tritici dispersed more than F. occidentalis. The presence of the predator enhanced movement by thrips from ßowers in which they were released. Despite differences in preymovement,O. insidiosus successfully preyed on all types of prey that were offered. However, O. insidiosus appeared to deal differently with each type of prey. Predation of both larvae and adults was most likely to occur inside ßowers. In trials with adults and second instars of F. occidentalis, larvaewere signiÞcantlymorevulnerable topredation thanwereadults.F. tritici, themore active species, may have been vulnerable to predation because of higher rates of encounter with the predator; however, O. insidiosus may have had greater attack success against the less active F. occidentalis. The ability ofO. insidiosus to prey successfully ondifferent life stages and species of thrips in complex environments indicates that it is an efÞcient predator of thrips and an important biological control agent.
Concurrent chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma: treatment outcomes of a prospective, multicentric clinical study.

BACKGROUND AND PURPOSE
To evaluate long-term outcome in locoregionally advanced nasopharyngeal carcinoma (NPC) treated with intensity-modulated radiation therapy (IMRT) and concurrent chemotherapy.


MATERIAL AND METHODS
Between January 2006 and August 2008, 249 patients with stage III-IVb NPC were treated by IMRT plus concurrent chemotherapy in this multicenter prospective study.


RESULTS
With a mean follow-up of 54.1 months, the 5-year actuarial rates of overall survival (OS), local recurrence-free survival (LRFS), regional recurrence-free survival (RRFS), and distant metastasis-free survival (DMFS) were 78.4%, 86.8%, 88.4%, 78.0%, respectively. There were 29 local recurrences, 25 regional recurrences and 52 distant metastases, respectively. Distant metastasis is the main cause of treatment failure. N-stage was an independent prognostic factor for LRFS, RRFS, DMFS and OS. Acute toxicity ⩾grade III mainly consisted of mucositis (34.9%), neutropenia (11.2%), xerostomia (5.6%), and dermatitis (5.2%). The main documented late toxicity was xerostomia, and the severity of xerostomia decreased over time. At 24 months after treatment, 13.2% of patients had grade 2 xerostomia, and none had grade 3 or 4 xerostomia.


CONCLUSIONS
IMRT with concurrent cisplatin chemotherapy resulted in encouraging rates of local and distant control and overall survival with acceptable rates of acute and limited rates of late toxicity in patients with locoregionally advanced NPC. Distant metastasis remained the main cause of failure. More effective systemic therapy should be explored for patients with advanced N-stage.
Associations between smoking and alcohol drinking and suicidal behavior in Korean adolescents: Korea Youth Behavioral Risk Factor Surveillance, 2006.

OBJECTIVE
To assess any association between cigarette smoking and heavy drinking and suicidal ideation and suicide attempts among boys and girls in a nationally representative sample of Korean adolescents.


METHOD
The analysis was performed using data from the 2006 Korea Youth Behavioral Risk Factor Surveillance study, which included a representative sample of middle and high school students in Korea. Logistic regression analyses were conducted to examine whether smoking and drinking were associated with suicidal behavior among boys and girls, controlling for demographic characteristics, perceived stress, perceived sadness/hopelessness, and chronic disease.


RESULTS
Of the 70,486 study subjects, 23.3% (19.1% of boys and 27.9% of girls) reported suicidal ideation and 5.3% (4.6% of boys and 6.1% of girls) reported having attempted suicide during the previous 12 months. Cigarette smoking and heavy drinking were found to be significantly associated with suicidal ideation and suicidal attempts among boys and girls.


CONCLUSION
Smoking and heavy drinking among adolescents are important factors related to suicidal ideation and attempting suicide in boys and girls. Further research is needed to clarify any causal connection between cigarette smoking and heavy drinking and suicidal ideation and suicide attempts.
Joint Optical Flow and Temporally Consistent Semantic Segmentation

The importance and demands of visual scene understanding have been steadily increasing along with the active development of autonomous systems. Consequently, there has been a large amount of research dedicated to semantic segmentation and dense motion estimation. In this paper, we propose a method for jointly estimating optical flow and temporally consistent semantic segmentation, which closely connects these two problem domains and leverages each other. Semantic segmentation provides information on plausible physical motion to its associated pixels, and accurate pixel-level temporal correspondences enhance the accuracy of semantic segmentation in the temporal domain. We demonstrate the benefits of our approach on the KITTI benchmark, where we observe performance gains for flow and segmentation. We achieve stateof-the-art optical flow results, and outperform all published algorithms by a large margin on challenging, but crucial dynamic objects.
Structured hypocaloric diet is more effective than behavioral therapy in reducing metabolic syndrome in Mexican postmenopausal women: a randomized controlled trial.

OBJECTIVE
This study aims to compare the effects of a lifestyle intervention using a behavioral therapy (BT) approach with the effects of a cardioprotective structured hypocaloric diet on metabolic syndrome in Mexican postmenopausal women.


METHODS
This study is a randomized clinical trial (2006-2009) of Mexican postmenopausal women with metabolic syndrome (Adult Treatment Panel III criteria) who were recruited from the Postmenopause Clinic of the National Institute of Perinatology in Mexico City. Women were assigned to one of two groups--group 1 (structured hypocaloric diet; n = 63): energy restriction (-300 to -500 kcal/d) emphasizing cardioprotective dietary changes; and group 2 (BT; n = 55): goal setting, problem-solving, and stimulus control to achieve cardioprotective dietary and lifestyle recommendations. Metabolic syndrome prevalence, as well as weight, waist circumference, fat mass, and fasting biochemical markers (glucose and lipid profile), were measured at baseline and at 2, 4, and 6 months after the intervention. Metabolic syndrome risk (relative risk and absolute risk reduction), mean differences between groups, and logistic regression were evaluated using Statistical Package for the Social Sciences software, version 17.0.


RESULTS
A total of 118 women were studied (mean [SD] age, 53.81 [6.43] y). No baseline differences were observed between groups. At the end of the study, a higher reduction in metabolic syndrome prevalence was observed in group 1 (-38.1%) compared with group 2 (-12.7%; relative risk, 0.237; 95% CI, 0.092-0.608; P = 0.003). The effect was maintained even when adjusted by age, hormone therapy and antihypertensive drug use.


CONCLUSIONS
A cardioprotective structured hypocaloric diet is more effective than the BT approach in reducing metabolic syndrome after 6 months of intervention. Both strategies have positive effects on different individual cardiovascular risk factors.
Discounts and rebates granted to public payers for medicines in European countries

OBJECTIVE
The objective of this study was to provide an overview about the existence and types of discounts and rebates granted to public payers by the pharmaceutical industry in European countries.


METHODS
Data were collected via a questionnaire in spring 2011. Officials from public authorities for pharmaceutical pricing and reimbursement represented in the PPRI (Pharmaceutical Pricing and Reimbursement Information) network provided the information and reviewed the compilation.


RESULTS
Information is available from 31 European countries. Discounts and rebates granted to public payers by pharmaceutical industry were reported for 25 European countries. Such discounts exist both in the in- and out-patient sectors in 21 countries and in the in-patient sector only in four countries. Six countries reported not having any regulations or agreements regarding the discounts and rebates granted by industry. The most common discounts and rebates are price reductions and refunds linked to sales volume but types such as in-kind support, price-volume and risk-sharing agreements are also in place. A mix of various types of discounts and rebates is common. Many of these arrangements are confidential. Differences regarding types, the organizational and legal framework, validity and frequency of updates and the amount of the discounts and rebates granted exist among the surveyed countries.


CONCLUSIONS
In Europe, discounts and rebates on medicines granted by pharmaceutical industry to public payers are common tools to contain public pharmaceutical expenditure. They appear to be used as a complimentary measure when price regulation does not achieve the desired results and in the few European countries with no or limited price regulation. The confidential character of many of these arrangements impedes transparency and may lead to a distortion of medicines prices. An analysis of the impact on these measures is recommended.
Accelerating Deep Convolutional Networks using low-precision and sparsity

We explore techniques to significantly improve the compute efficiency and performance of Deep Convolution Networks without impacting their accuracy. To improve the compute efficiency, we focus on achieving high accuracy with extremely low-precision (2-bit) weight networks, and to accelerate the execution time, we aggressively skip operations on zero-values. We achieve the highest reported accuracy of 76.6% Top-1/93% Top-5 on the Imagenet object classification challenge with low-precision network while reducing the compute requirement by ∼3× compared to a full-precision network that achieves similar accuracy. Furthermore, to fully exploit the benefits of our low-precision networks, we build a deep learning accelerator core, DLAC, that can achieve up to 1 TFLOP/mm2 equivalent for single-precision floating-point operations (∼2 TFLOP/mm2 for half-precision), which is ∼5× better than Linear Algebra Core [16] and ∼4× better than previous deep learning accelerator proposal [8].
Trans-Eurasian transport of ozone and its precursors

[1] Long-range transport of air across the European and Asian continents brings substantial quantities of ozone and other oxidants to northeast Asia from upwind sources over Europe and North America. This transport differs significantly from that over the Pacific and Atlantic Oceans because of weaker and less frequent frontal systems over the continent and because of weaker convective lifting over European sources. Slower O3 formation, faster destruction at low altitudes, and greater deposition over continental regions lead to Europe having a smaller impact on O3 than other source regions. We present chemical transport model studies of the formation and transport of O3 from European precursor sources and investigate the extent of their impacts over Eurasia. We focus on measurement sites at 100 E, representing the inflow to east Asia on which regional pollutant sources build, and on northeast Asia, which may be directly affected by transport across Eurasia. The seasonality in O3 production over Europe is simulated well, and transport principally in the boundary layer propagates these changes in O3 over Eurasia, leading to monthly mean impacts at Mondy, Siberia, of 0.5–3.5 ppbv. Impacts over Japan are smaller, 0.2–2.5 ppbv, and are very similar to those from North American sources, which dominate at higher altitudes. By following the effect of daily emissions independently, we clearly demonstrate that this greater North American impact is associated with lifting over the Atlantic. European and North American sources contribute to background O3 over Japan in the anticyclonic conditions that favor regional O3 buildup and are thus expected to have a small but significant effect on regional air quality. Finally, we demonstrate that location and transport lead to European sources having a different impact on OH, and hence on tropospheric oxidizing capacity and climate, from other major Northern Hemisphere source regions.