LLukas22/scidocs huggingface dataset:
Emergency centre investigation of first-onset seizures in adults in the Western Cape, South Africa.

BACKGROUND
Patients with first-onset seizures commonly present to emergency centres (ECs). The differential diagnosis is broad, potentially life-threatening conditions need to be excluded, and these patients need to be correctly diagnosed and appropriately referred. There are currently no data on adults presenting with first-onset seizures to ECs in South Africa.


OBJECTIVE
To review which investigations were performed on adults presenting with first-onset seizures to six ECs in the Western Cape Province.


METHODS
A prospective, cross-sectional study was conducted from 1 July 2011 to 31 December 2011. All adults with first-onset seizures were included; children and trauma patients were excluded. Subgroup analyses were conducted regarding HIV status and inter-facility variation.


RESULTS
A total of 309 patients were included. Computed tomography (CT) scans were planned in 218 (70.6%) patients, but only performed in 169; 96 (56.8%) showed abnormalities judged to be causative (infarction, intracerebral haemorrhage and atrophy being the most common). At least 80% of patients (n=247) received a full renal and electrolyte screen, blood glucose testing and a full haematological screen. Lumbar puncture (LP) was performed in 67 (21.7%) patients, with normal cerebrospinal fluid findings in 51 (76.1%). Only 27 (8%) patients had an electroencephalogram, of which 5 (18%) were abnormal. There was a statistically significant difference in the number of CT scans (p=0.002) and LPs (p<0.001) performed in the HIV-positive group (n=49).


CONCLUSION
This study demonstrated inconsistency and wide local variance for all types of investigations done. It emphasises the need for a local guideline to direct doctors to appropriate investigations, ensuring better quality patient care and potential cost-saving.
Finite Element Method Simulation of Machining of AISI 1045 Steel With A Round Edge Cutting Tool Tu ğ

In this paper, FEM modeling and simulation of orthogonal cutting of AISI 1045 steel is studied by using dynamics explicit Arbirary Lagrangian Eulerian method. The simulation model utilizes the advantages offered by ALE method in simulating plastic flow around the round edge of the cutting tool and eliminates the need for chip separation criteria. JohnsonCook work material model is used for elastic plastic work deformations. A methodology developed to determine friction characteristics from orthogonal cutting tests is also utilized for chip-tool interfacial friction modeling. The simulation results include predicted chip formation as well as temperature and stress distributions. These results are highly essential in predicting machining induced residual stresses and other properties on the machined surface.
A trust-based consumer decision-making model in electronic commerce: The role of trust, perceived risk, and their antecedents

Are trust and risk important in consumers' electronic commerce purchasing decisions? What are the antecedents of trust and risk in this context? How do trust and risk affect an Internet consumer's purchasing decision? To answer these questions, we i) develop a theoretical framework describing the trust-based decision-making process a consumer uses when making a purchase from a given site, ii) test the proposed model using a Structural Equation Modeling technique on Internet consumer purchasing behavior data collected via a Web survey, and iii) consider the implications of the model. The results of the study show that Internet consumers' trust and perceived risk have strong impacts on their purchasing decisions. Consumer disposition to trust, reputation, privacy concerns, security concerns, the information quality of the Website, and the company's reputation, have strong effects on Internet consumers' trust in the Website. Interestingly, the presence of a third-party seal did not strongly influence consumers' trust. © 2007 Elsevier B.V. All rights reserved.
On the origin of the bilateral filter and ways to improve it

Additive noise removal from a given signal is an important problem in signal processing. Among the most appealing aspects of this field are the ability to refer it to a well-established theory, and the fact that the proposed algorithms in this field are efficient and practical. Adaptive methods based on anisotropic diffusion (AD), weighted least squares (WLS), and robust estimation (RE) were proposed as iterative locally adaptive machines for noise removal. Tomasi and Manduchi (see Proc. 6th Int. Conf. Computer Vision, New Delhi, India, p.839-46, 1998) proposed an alternative noniterative bilateral filter for removing noise from images. This filter was shown to give similar and possibly better results to the ones obtained by iterative approaches. However, the bilateral filter was proposed as an intuitive tool without theoretical connection to the classical approaches. We propose such a bridge, and show that the bilateral filter also emerges from the Bayesian approach, as a single iteration of some well-known iterative algorithm. Based on this observation, we also show how the bilateral filter can be improved and extended to treat more general reconstruction problems.
On parallel integer sorting

We present an optimal algorithm for sortingn integers in the range [1,n c ] (for any constantc) for the EREW PRAM model where the word length isn ε , for any ε>0. Using this algorithm, the best known upper bound for integer sorting on the (O(logn) word length) EREW PRAM model is improved. In addition, a novel parallel range reduction algorithm which results in a near optimal randomized integer sorting algorthm is presented. For the case when the keys are uniformly distributed integers in an arbitrary range, we give an algorithm whose expected running time is optimal.
Benefits of partnered strength training for prostate cancer survivors and spouses: results from a randomized controlled trial of the Exercising Together project.

BACKGROUND
Prostate cancer can negatively impact quality of life of the patient and his spouse caregiver, but interventions rarely target the health of both partners simultaneously. We tested the feasibility and preliminary efficacy of a partnered strength training program on the physical and mental health of prostate cancer survivors (PCS) and spouse caregivers.


METHODS
Sixty-four couples were randomly assigned to 6 months of partnered strength training (Exercising Together, N = 32) or usual care (UC, N = 32). Objective measures included body composition (lean, fat and trunk fat mass (kg), and % body fat) by DXA, upper and lower body muscle strength by 1-repetition maximum, and physical function by the physical performance battery (PPB). Self-reported measures included the physical and mental health summary scales and physical function and fatigue subscales of the SF-36 and physical activity with the CHAMPS questionnaire.


RESULTS
Couple retention rates were 100 % for Exercising Together and 84 % for UC. Median attendance of couples to Exercising Together sessions was 75 %. Men in Exercising Together became stronger in the upper body (p < 0.01) and more physically active (p < 0.01) than UC. Women in Exercising Together increased muscle mass (p = 0.05) and improved upper (p < 0.01) and lower body (p < 0.01) strength and PPB scores (p = 0.01) more than UC.


CONCLUSIONS
Exercising Together is a novel couples-based approach to exercise that was feasible and improved several health outcomes for both PCS and their spouses.


IMPLICATIONS FOR CANCER SURVIVORS
A couples-based approach should be considered in cancer survivorship programs so that outcomes can mutually benefit both partners.


TRIAL REGISTRATION
ClinicalTrials.gov NCT00954044.
Validation of the functional assessment of cancer therapy-gastric module for the Chinese population

BACKGROUND
Quality of life (QoL) assessment has become an important aspect of the clinical management of gastric cancer (GC), which poses a greater health threat in Chinese populations around the world. Functional Assessment of Cancer Therapy-Gastric Module (FACT-Ga), a questionnaire developed specifically to measure QoL of patients with GC, has never been validated in Chinese subjects. The current study was designed to examine the psychometric properties of FACT-Ga as a GC specific QoL instrument for its future use in Chinese populations.


METHODS
A sample of 67 Chinese patients with GC in the National University Hospital, Singapore was investigated cross-sectionally. The participants independently completed either English or Chinese versions of the FACT-Ga and the European Quality of Life-5 Dimensions (EQ-5D). Reliability was measured as the Cronbach's α for EQ-5D, and five subscale scores and two total scores of FACT-Ga. The sensitivity to patients' clinical status was evaluated by comparing EQ-5D and FACT-Ga scores between clinical subgroups classified by Clinical Stage and Treatment Intent. The construct validity of FACT-Ga was assessed internally by examining the item-to-scale correlations and externally by contrasting the FACT-Ga subscales with the EQ-5D domains.


RESULTS
For both FACT-Ga and EQ-5D, patients treated with curative intent rated their QoL higher than those treated for palliation, and early stage patients scored higher than those in the late stage. The sensitivity to clinical status of FACT-Ga scores were differential as four of seven FACT-Ga scores were significant for Treatment Intent while only one subscale score was significant for Clinical Stage. Six FACT-Ga scores had Cronbach's α of 0.8 or above indicating excellent reliability. For construct validity, 45 of 46 items converged about their respective subscales. The monotrait-multimethod correlations between QoL constructs of FACT-Ga and EQ-5D were stronger than the multitrait-multimethod correlations as theoretically hypothesized, suggesting good convergent and discriminant validities.


CONCLUSIONS
Given the excellent reliability and good construct validity, FACT-Ga scores are able to distinguish patient groups with different clinical characteristics in the expected direction. Therefore FACT-Ga can be used as a discriminative instrument for measuring QoL of Chinese patients with GC.
A Communication Goals Model of Online Persuasion

Online communication media are being used increasingly for attempts to persuade message receivers. This paper presents a theoretical model that predicts outcomes of online persuasion based on the structure of primary and secondary goals message receivers hold toward the communication.
A randomized controlled trial of ultrasound-guided peripherally inserted central catheters compared with standard radiograph in neonates

Objective:The placement of a peripherally inserted central catheter (PICC) routinely incorporates tip position confirmation using standard radiographs. In this study, we sought to determine whether real-time ultrasound (RTUS) could be used to place a PICC in a shorter time period, with fewer manipulations and fewer radiographs than the use of radiographs to determine accurate placement.Study Design:This was a prospective, randomized, trial of infants who required PICC placement. Catheters were placed using either standard radiograph, with blinded evaluation of the catheters using RTUS or with RTUS guidance, with input on catheter tip location. The number of radiographs required to confirm proper positioning, duration of the procedure and manipulations of the lines were recorded for both groups. Final confirmation of PICC placement was by radiographs in both groups.Result:A total of 64 patients were enrolled in the study, with 16 failed PICC attempts. Of the 48 remaining infants, 28 were in the standard placement group and 20 were in the RTUS-guided group. The mean±s.d. gestational ages and weight at time of placement were 30±4 weeks and 1229±485 g, respectively. The RTUS use significantly decreased the time of line placement by 30 min (P=0.034), and decreased the median number of manipulations (0 vs 1, P=0.032) and radiographs (1 vs 2 P=0.001) taken to place the catheters. Early identification of the PICC by RTUS was possible in all cases and would have saved an additional 38 min if radiographs were not required.Conclusion:In the hands of ultrasound (US)-experienced neonatologists, RTUS-guided PICC placement reduces catheter insertion duration, and is associated with fewer manipulations and radiographs when compared with conventional placement.
Steady-state analysis of the set-membership affine projection algorithm

Among the adaptive filtering algorithms the set-membership affine projection (SM-AP) algorithm has the attractive feature of not trading off misadjustment with convergence speed. This paper presents an analysis of the steady-state mean-square error (MSE) of the SM-AP algorithm. Our analysis relies on the energy conservation method and does not assume a specific probability distribution for the input vector. Moreover, since the SM-AP algorithm with a fixed-modulus error-based constraint vector generalizes some important algorithms, such as the SM normalized least-mean-square (SM-NLMS) algorithm, the results can be directly applied to these algorithms. Simulation results confirm the accuracy of our analysis.
Combining Cognitive Behavioural Therapy and Pharmacotherapy in the Treatment of Anxiety Disorders : True Gains or False Hopes ?

Anxiety disorders such as obsessive-compulsive disorder (OCD), panic disorder, social anxiety disorder (SAD), generalized anxiety disorder (GA) and posttraumatic stress disorder (PTSD) are the most common of the psychiatric disorders worldwide with a prevalence of up to 18% (1). These disorders often only receive little attention by mental health services despite their great contribution to overall clinical burden and economic costs Combining Cognitive Behavioural Therapy and Pharmacotherapy in the Treatment of Anxiety Disorders: True Gains or False Hopes?
Correlation between plasma clozapine concentration and heart rate variability in schizophrenic patients

 Forty schizophrenic patients treated with 50–600 mg/day of clozapine as monotherapy and 40 normal control subjects were tested for heart rate variability (HRV) which is mediated by the vagus nerve using acetylcholine as neurotransmitter. As compared to the control subjects, the patients showed essentially reduced HRV parameters which were negatively correlated with the plasma clozapine levels. Therefore, clozapine’s anticholinergic effect is correlated to the plasma clozapine level when measured by the decrease of HRV. We suggest that HRV data might be useful as a predictor for plasma clozapine levels.
The security of shopping online

The online shopping is increasingly being accepted Internet users, which reflects the online shopping convenient, fast, efficient and economic advantage. Online shopping, personal information security is a major problem in the Internet. This article summarizes the characteristics of online shopping and the current development of the main safety problems, and make online shopping related security measures and transactions.
Brain responses to lexical-semantic priming in children at-risk for dyslexia

Deviances in early event-related potential (ERP) components reflecting auditory and phonological processing are well-documented in children at familial risk for dyslexia. However, little is known about brain responses which index processing in other linguistic domains such as lexicon, semantics and syntax in this group. The present study investigated effects of lexical-semantic priming in 20- and 24-month-olds at-risk for dyslexia and typically developing controls in two ERP experiments. In both experiments an early component assumed to reflect facilitated lexical processing for primed words was enhanced in the at-risk group compared to the control group. Moreover, an N400-like response which was prominent in the control group was attenuated or absent in at-risk children. Results suggest that deficiencies in young children at-risk for dyslexia are not restricted to perceptual and lower-level phonological abilities, but also affect higher order linguistic skills such as lexical and semantic processing.
Obesity relationships with community design, physical activity, and time spent in cars.

BACKGROUND
Obesity is a major health problem in the United States and around the world. To date, relationships between obesity and aspects of the built environment have not been evaluated empirically at the individual level.


OBJECTIVE
To evaluate the relationship between the built environment around each participant's place of residence and self-reported travel patterns (walking and time in a car), body mass index (BMI), and obesity for specific gender and ethnicity classifications.


METHODS
Body Mass Index, minutes spent in a car, kilometers walked, age, income, educational attainment, and gender were derived through a travel survey of 10,878 participants in the Atlanta, Georgia region. Objective measures of land use mix, net residential density, and street connectivity were developed within a 1-kilometer network distance of each participant's place of residence. A cross-sectional design was used to associate urban form measures with obesity, BMI, and transportation-related activity when adjusting for sociodemographic covariates. Discrete analyses were conducted across gender and ethnicity. The data were collected between 2000 and 2002 and analysis was conducted in 2004.


RESULTS
Land-use mix had the strongest association with obesity (BMI >/= 30 kg/m(2)), with each quartile increase being associated with a 12.2% reduction in the likelihood of obesity across gender and ethnicity. Each additional hour spent in a car per day was associated with a 6% increase in the likelihood of obesity. Conversely, each additional kilometer walked per day was associated with a 4.8% reduction in the likelihood of obesity. As a continuous measure, BMI was significantly associated with urban form for white cohorts. Relationships among urban form, walk distance, and time in a car were stronger among white than black cohorts.


CONCLUSIONS
Measures of the built environment and travel patterns are important predictors of obesity across gender and ethnicity, yet relationships among the built environment, travel patterns, and weight may vary across gender and ethnicity. Strategies to increase land-use mix and distance walked while reducing time in a car can be effective as health interventions.
Plasma proteasome level is a reliable early marker of malignant transformation of liver cirrhosis.

BACKGROUND
Proteasomes are the main non-lysosomal proteolytic structures which regulate crucial cellular processes. Circulating proteasome levels can be measured using an ELISA test and can be considered as a tumour marker in several types of malignancy. Given that there is no sensitive marker of hepatocellular carcinoma (HCC) in patients with cirrhosis, we measured plasma proteasome levels in 83 patients with cirrhosis (33 without HCC, 50 with HCC) and 40 controls.


METHODS AND RESULTS
Patients with HCC were sub-classified into three groups according to tumour mass. alpha-Fetoprotein (AFP) was also measured. Plasma proteasome levels were significantly higher in patients with HCC compared to controls (4841 (SEM 613) ng/ml vs 2534 (SEM 187) ng/ml; p<0.001) and compared to patients with cirrhosis without HCC (2077 (SEM 112) ng/ml; p<0.001). This difference remained significant when the subgroup of patients with low tumour mass (proteasome level 3970 (SEM 310) ng/ml, p<0.001) was compared to controls and patients with cirrhosis without HCC. Plasma proteasome levels were independent of the cause of cirrhosis and were weakly correlated with AFP levels. With a cut-off of 2900 ng/ml, diagnostic specificity for HCC was 97% with a sensitivity of 72%, better than results obtained with AFP. Diagnostic relevance of plasma proteasome measurement was also effective in low tumour mass patients (sensitivity 76.2% vs 57.1% for AFP).


CONCLUSION
The plasma proteasome level is a reliable marker of malignant transformation in patients with cirrhosis, even when there is a low tumour mass.
Late Simultaneous Metastasis of Renal Cell Carcinoma to the Submandibular and Thyroid Glands Seven Years after Radical Nephrectomy

Background. Renal cell carcinoma (RCC) metastasis to the salivary glands is extremely rare. Most cases reported previously have involved the parotid gland and only six cases involving the submandibular gland exist in the current literature. Metastasis of RCC to thyroid gland is also rare but appears to be more common than to salivary glands. Methods and Results. We present the first case of simultaneous metastasis to the submandibular and thyroid glands from clear cell RCC in a 61-year-old woman who presented seven years after the primary treatment. The submandibular and thyroid glands were excised completely with preservation of the marginal mandibular and recurrent laryngeal nerves, respectively. Conclusion. Metastatic disease should always be considered in the differential diagnosis for patients who present with painless salivary or thyroid gland swelling with a previous history of RCC. If metastatic disease is confined only to these glands, prompt surgical excision can be curative.
Co-medication of statins and CYP3A4 inhibitors before and after introduction of new reimbursement policy.

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT
HMG-CoA reductase inhibitors (statins) are frequently used drugs in the treatment of dyslipidaemia. Co-medication with interacting drugs increases the risk of statin-induced muscular side-effects. Simvastatin exhibits particularly high interaction potential due to substantial metabolism via cytochrome P450 3A4 (CYP3A4).


WHAT THIS STUDY ADDS
In June 2005, a new reimbursement policy was introduced by the Norwegian Medicines Agency stating that simvastatin should be prescribed as first-line lipid-lowering therapy. Following introduction of the new policy, the number of patients co-medicated with simvastatin and CYP3A4 inhibitors almost doubled. A potential consequence is increased incidence of muscular side-effects in the statin-treated population.


AIMS
To assess the prevalence of co-medication of statins and CYP3A4 inhibitors before and after introduction of a new Norwegian reimbursement policy, which states that all patients should be prescribed simvastatin as first-line lipid-lowering therapy.


METHODS
Data from patients receiving simvastatin, lovastatin, pravastatin, fluvastatin or atorvastatin in 2004 and 2006, including co-medication of potent CYP3A4 inhibitors, were retrieved from the Norwegian Prescription Database covering the total population of Norway. Key measurements were prevalence of continuous statin use (two or more prescriptions on one statin) and proportions of different statin types among all patients and those co-medicated with CYP3A4 inhibitors.


RESULTS
In 2004, 5.9% (n= 272 342) of the Norwegian population received two or more prescriptions on one statin compared with 7.0% (n= 324 267) in 2006. The relative number of simvastatin users increased from 39.7% (n= 112 122) in 2004 to 63.1% (n= 226 672) in 2006. A parallel increase was observed within the subpopulation co-medicated with statins and CYP3A4 inhibitors, i.e. from 42.9% (n= 7706) in 2004 to 63.6% (n= 13 367) in 2006. For all other statins the number of overall users decreased to a similar extent to those co-medicated with CYP3A4 inhibitors.


CONCLUSIONS
In both 2004 and 2006, the choice of statin type did not depend on whether the patient used a CYP3A4 inhibitor or not. Considering the pronounced interaction potential of simvastatin with CYP3A4 inhibitors, a negative influence of the new policy on overall statin safety seems likely.