LLukas22/scidocs huggingface dataset:
Discrepancy of target sites between clinician and cytopathological reports in head neck fine needle aspiration: Did I miss the target or did the clinician mistake the organ site?

The diagnostic accuracy of fine needle aspiration cytology (FNAC) of head and neck lesions is relatively high, but cytologic interpretation might be confusing if the sample is lacking typical cytologic features according to labeled site by physician. These errors may have an impact on pathology search engines, healthcare costs or even adverse outcomes. The cytology archive database of multiple institutions in southern Iran and Australia covering the period 2001-2011, were searched using keywords: salivary gland, head, neck, FNAC, and cytology. All the extracted reports were reviewed. The reports which showed discordance between the clinician's impression of the organ involved and subsequent fine needle biopsy request, and the eventual cytological diagnosis were selected. The cytological diagnosis was confirmed by histology or cell block, with assistance from imaging, clinical outcome, physical examination, molecular studies, or microbiological culture. The total number of 10,200 head and neck superficial FNAC were included in the study, from which 48 cases showed discordance between the clinicians request and the actual site of pathology. Apart from the histopathology, the imaging, clinical history, physical examination, immunohistochemical study, microbiologic culture and molecular testing helped to finalize the target organ of pathology in 23, 6, 7, 8, 2, and 1 cases respectively. The commonest discrepancies were for FNAC of "salivary gland" [total: 20 with actual final pathology in: bone (7), soft tissue (5), lymph node (3), odontogenic (3) and skin (2)], "lymph node" [total: 12 with final pathology in: soft tissue (3), skin (3), bone (1) and brain (1)], "soft tissue" [total: 11 with final pathology in: bone (5), skin (2), salivary gland (1), and ocular region (1)] and "skin" [total: 5 with final pathology in: lymph node (2), bone (1), soft tissue (1) and salivary gland (1)]. The primary physician requesting FNAC of head and neck lesions are incorrect in their clinical impression of the actual site in nearly 0.5 percent of cases, due to the overlapping clinical and imaging findings or possibly due to inadequate history taking or physical examination.
Analyzing feature trajectories for event detection

We consider the problem of analyzing word trajectories in both time and frequency domains, with the specific goal of identifying important and less-reported, periodic and aperiodic words. A set of words with identical trends can be grouped together to reconstruct an event in a completely un-supervised manner. The document frequency of each word across time is treated like a time series, where each element is the document frequency - inverse document frequency (DFIDF) score at one time point. In this paper, we 1) first applied spectral analysis to categorize features for different event characteristics: important and less-reported, periodic and aperiodic; 2) modeled aperiodic features with Gaussian density and periodic features with Gaussian mixture densities, and subsequently detected each feature's burst by the truncated Gaussian approach; 3) proposed an unsupervised greedy event detection algorithm to detect both aperiodic and periodic events. All of the above methods can be applied to time series data in general. We extensively evaluated our methods on the 1-year Reuters News Corpus [3] and showed that they were able to uncover meaningful aperiodic and periodic events.
'Living stones' reveal alternative petal identity programs within the core eudicots.

Petals, defined as the showy laminar floral organs in the second floral whorl, have been shown to be under similar genetic control in distantly related core eudicot model organisms. On the basis of these findings, it is commonly assumed that the petal identity program regulated by B-class MADS-box gene homologs is invariant across the core eudicot clade. However, the core eudicots, which comprise >70% of angiosperm species, exhibit numerous instances of petal and sepal loss, transference of petal function between floral whorls, and recurrent petal evolution. In the face of these complex patterns of perianth evolution, the concept of a core eudicot petal identity program has not been tested. We therefore examined the petal identity program in the Caryophyllales, a core eudicot clade in which perianth differentiation into sepals and petals has evolved multiple times. Specifically, we analyzed the expression patterns of B- and C-class MADS-box homologs for evidence of a conserved petal identity program between sepal-derived and stamen-derived petaloid organs in the 'living stone' family Aizoaceae. We found that neither sepal-derived nor stamen-derived petaloid organs exhibit gene expression patterns consistent with the core eudicot petal identity program. B-class gene homologs are not expressed during the development of sepal-derived petals and are not implicated in petal identity in stamen-derived petals, as their transient expression coincides with early expression of the C-class homolog. We therefore provide evidence for petal development that is independent of B-class genes and suggest that different genetic control of petal identity has evolved within this lineage of core eudicots. These findings call for a more comprehensive understanding of perianth variation and its genetic causes within the core eudicots--an endeavor that will have broader implications for the interpretation of perianth evolution across angiosperms.
Commonsense reasoning and commonsense knowledge in artificial intelligence

AI has seen great advances of many kinds recently, but there is one critical area where progress has been extremely slow: ordinary commonsense.
Clinical and demographic characteristics of children with hypertension.

Most information describing hypertension in the young comes from single-center reports. To better understand contemporary demographic and clinical characteristics of hypertensive children and adolescents, we examined baseline data on 351 children aged 1 to <17 years old who were enrolled in 2 multicenter trials of valsartan. Anthropometric, laboratory, and demographic information at randomization was extracted from the clinical trials databases. Summary variables were created and compared for 3 age groups: <6 years (n=90), 6 to <12 years (n=131), and 12 to <17 years (n=130). Comparisons were also made between different etiologies of hypertension and for different anthropometric categories. Children<6 years old were significantly more likely to have secondary hypertension and were significantly less likely to have weight or body mass index>95 percentile compared with older children. Estimated glomerular filtration rate was significantly lower in children<6 years old (90.9±31.8 mL/min per 1.73 m2) than in the other 2 age groups (6 to <12 years, 141.4±42.1 mL/min per 1.73 m2; 12 to <17 years, 138.3±46.0 mL/min per 1.73 m2). Frequency of total cholesterol>95 percentile was significantly lower in children aged<6 years. Diastolic blood pressure index (subject blood pressure÷95 percentile) was significantly higher in children<6 years old (1.1 versus 1.0 in both the 6 to <12 years and 12 to <17 years groups; both P<0.0001). We conclude that hypertensive children<6 years are more likely to have secondary hypertension and to have higher diastolic blood pressure and lower glomerular filtration rate and are less likely to be obese or to have elevated cholesterol than school-aged children or adolescents. These findings emphasize unique aspects of childhood hypertension that should be considered when evaluating children and adolescents with elevated blood pressure and in designing future clinical trials.
Relevance of the diagnosis traumatic cervical Brown-Séquard-plus syndrome: an analysis based on the neurological and functional recovery in a prospective cohort of 148 patients

Study design:Prospective multi-center cohort study.Objectives:To compare the neurological and functional recovery between tetraplegic Brown-Séquard-plus syndrome (BSPS) and incomplete tetraplegia (non-BSPS).Setting:European Multicenter Study of Human Spinal Cord Injury (EM-SCI).Methods:BSPS was defined as a traumatic incomplete spinal cord injury (SCI) with ipsilateral weakness and contralateral loss of pinprick sensation at neurologic levels C2–T1. Acute (0–15 days) and chronic phase (6 or 12 months) were assessed for the American Spinal Injury Association (ASIA) sensory scores, upper extremity motor scores and lower extremity motor scores. Furthermore, chronic phase scores of all Spinal Cord Independence Measure (SCIM) II items were analyzed. Differences in neurological and functional outcome between BSPS patients and non-BSPS patients were calculated using Student's t-tests and Wilcoxon signed rank tests.Results:Out of 148 tetraplegic patients, 30 were diagnosed with BSPS. Patients with an ASIA impairment scale (AIS) B were significantly (P<0.001) more identified in non-BSPS patients (25%) compared with BSPS patients (3%), respectively. After 12 months, the median scores for sphincter management of the bladder for both BSPS and non-BSPS patients were 15. Both 25 and 75% quartile median scores were 15 for BSPS patients and 12 and 15 for non-BSPS patients (P<0.02). Except for the difference in bladder function, no significant differences were identified in other SCIM II subitems and ASIA motor or sensory scores between BSPS and non-BSPS patients when stratified for injury severity by excluding AIS B patients.Conclusion:Compared with incomplete tetraplegic patients, patients with cervical BSPS have a similar neurological and functional recovery when matched for the AIS.
Zooplankton-mediated changes of bacterial community structure

Enclosure experiments in the mesotrophic Schöhsee in northern Germany were designed to study the impact of metazooplankton on components of the microbial food web (bacteria, flagellates, ciliates). Zooplankton was manipulated in 500-liter epilimnetic mesocosms so that either Daphnia or copepods were dominating, or metazooplankton was virtually absent. The bacterial community responded immediately to changes in zooplankton composition. Biomass, productivity, and especially the morphology of the bacteria changed drastically in the different treatments. Cascading predation effects on the bacterioplankton were transmitted mainly by phagotrophic protozoans which had changed in species composition and biomass. When Daphnia dominated, protozoans were largely suppressed and the original morphological structure of the bacteria (mainly small rods and cocci) remained throughout the experiment. Dominance of copepods or the absence of metazoan predators resulted in a mass appearance of bacterivorous protists (flagellates and ciliates). They promoted a fast decline of bacterial abundance and a shift to the predominance of morphologically inedible forms, mainly long filaments. After 3 days they formed 80–90% of the bacterial biomass. The results indicate that metazooplankton predation on phagotrophic protozoans is a key mechanism for the regulation of bacterioplankton density and community structure.
Generalized Nash Equilibria for the Service Provisioning Problem in Multi-Cloud Systems

The adoption of cloud technologies is steadily increasing. In such systems, applications can benefit from nearly infinite virtual resources on a pay-per-use basis. However, being the cloud massively multi-tenant and characterized by highly variable workloads the development of more and more effective provisioning policies assumes paramount importance. Boosted by the success of the cloud, the application of Game Theory models and methodologies has also become popular, since they have been demonstrated to suit perfectly to cloud social, economic, and strategic structures. This paper aims to study, model and efficiently solve the cost minimization problem associated with the service provisioning of SaaS virtual machines in multiple IaaSs. We propose a game-theoretic approach for the runtime management of resources from multiple IaaS providers to be allocated to multiple competing SaaSs, along with a cost model including revenues and penalties for requests execution failures. A distributed algorithm for identifying Generalized Nash Equilibria has been developed and analysed in detail. The effectiveness of our approach has been assessed by performing a wide set of analyses under multiple workload conditions. Results show that our algorithm is scalable and provides significant cost savings with respect to alternative methods (80 percent on average). Furthermore, increasing the number of IaaS providers SaaSs can achieve 9-15 percent cost savings from the workload distribution on multiple IaaSs.
Macroscopic rotation of photon polarization induced by a single spin

Entangling a single spin to the polarization of a single incoming photon, generated by an external source, would open new paradigms in quantum optics such as delayed-photon entanglement, deterministic logic gates or fault-tolerant quantum computing. These perspectives rely on the possibility that a single spin induces a macroscopic rotation of a photon polarization. Such polarization rotations induced by single spins were recently observed, yet limited to a few 10(-3) degrees due to poor spin-photon coupling. Here we report the enhancement by three orders of magnitude of the spin-photon interaction, using a cavity quantum electrodynamics device. A single hole spin in a semiconductor quantum dot is deterministically coupled to a micropillar cavity. The cavity-enhanced coupling between the incoming photons and the solid-state spin results in a polarization rotation by ± 6° when the spin is optically initialized in the up or down state. These results open the way towards a spin-based quantum network.
COSMOS * : a COmponent System MOdel for Software Architectures

Software architecture and component-based development are complementary approaches to the development of intensive software systems. Software architecture describes a system in terms of its logical architectural components, while component-based development focuses on the reuse of existing software components for building new software systems. However, software components are usually developed in programming languages that do not include component and software architecture abstractions, such as interfaces, architectural components and architectural connectors. So there is a gap between the conception of an abstract software architecture and its concrete implementation in a programming language. The COSMOS* model uses programming language features and well-known design patterns to represent software architectures explicitly in the program code. The COSMOS* model defines the specification and implementation of COSMOS* components, COSMOS* connectors, COSMOS* architectural configurations, and COSMOS* composite components. Case studies applying the COSMOS* model are discussed using the Java programming language.
Time course of lesion development in the hairless guinea-pig model of sulfur mustard-induced dermal injury.

The objective of these studies was to provide detailed analyses of the time course of sulfur mustard (SM) vapor-induced clinical, histological, and biochemical changes following cutaneous exposure in hairless guinea-pigs. Three 6 cm(2) sites on the backs of each guinea-pig were exposed to SM vapor (314 mg(3) ) for 6 minutes (low dose) or 12 minutes (high dose). Animals were killed at 6, 24, and 48 hours, or 2 weeks postexposure. Erythema, edema, histopathology, and analysis of matrix metalloproteinase (MMP)-2 and -9 content were evaluated. Erythema was observed by 6 hours, and edema by 24 hours postexposure. Vapor exposure caused epidermal necrosis with varying degrees of dermatitis, ulceration, hemorrhage, and separation of the dermis from the epidermis. Later changes included epidermal regeneration with hyperplasia and formation of granulation tissue in the dermis with loss of hair follicles and glandular structures. Relative amounts of pro and active MMP-2 and MMP-9 were significantly increased in the high-dose SM group at 2 weeks. Erythema, edema, and histologic changes are consistent with findings among human victims of SM attack. This model, with observations to 2 weeks, will be useful in assessing the efficacy of countermeasures against SM.
Assessment of serum N-terminal pro-B-type natriuretic peptide concentration for differentiation of congestive heart failure from primary respiratory tract disease as the cause of respiratory signs in dogs.

OBJECTIVE
To determine whether serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentration is useful in discriminating between cardiac and noncardiac (ie, primary respiratory tract disease) causes of respiratory signs (ie, coughing, stertor, stridor, excessive panting, increased respiratory effort, tachypnea, or overt respiratory distress) in dogs.


DESIGN
Multicenter cross-sectional study.


ANIMALS
P 115 dogs with respiratory signs.


PROCEDURES
Dogs with respiratory signs were solicited for study. Physical examination, thoracic radiography, and echocardiography were used to determine whether respiratory signs were the result of cardiac (ie, congestive heart failure) or noncardiac (ie, primary respiratory tract disease) causes. Serum samples for NT-proBNP assay were obtained at time of admission for each dog. Receiver-operating characteristic curves were constructed to determine the ability of serum NT-proBNP concentration to discriminate between cardiac and noncardiac causes of respiratory signs.


RESULTS
Serum NT-proBNP concentration was significantly higher in dogs with cardiac versus noncardiac causes of respiratory signs. In dogs with primary respiratory tract disease, serum NT-proBNP concentration was significantly higher in those with concurrent pulmonary hypertension than in those without. A serum NT-proBNP cutoff concentration > 1,158 pmol/L discriminated between dogs with congestive heart failure and dogs with primary respiratory tract disease with a sensitivity of 85.5% and a specificity of 81.3%.


CONCLUSIONS AND CLINICAL RELEVANCE
Measuring serum NT-proBNP concentration in dogs with respiratory signs helps to differentiate between congestive heart failure and primary respiratory tract disease as an underlying cause.
Predictors for Half-Year Outcome of Impairment in Daily Life for Back Pain Patients Referred for Physiotherapy: A Prospective Observational Study

BACKGROUND AND OBJECTIVE
From observational studies, there is only sparse information available on the predictors of development of impairment in daily life for patients receiving physiotherapy. Therefore, our aim was to identify factors which predict impairment in daily life for patients with back pain 6 months after receiving physiotherapy.


METHODS
We conducted a prospective cohort study with 6-month follow-up. Patients were enrolled for treatment in private physiotherapy practices. Patients with a first physiotherapy referral because of thoracic or low back pain, aged 18 to 65 years were included. Primary outcome impairment was measured utilising the 16-item version of the Musculoskeletal Function Assessment Questionnaire. Therapy was documented on a standardized form. Baseline scores for impairment in daily life, symptom characteristics, sociodemographic and psychosocial factors, physical activity, nicotine consumption, intake of analgesics, comorbidity and delivered primary therapy approach were investigated as possible predictors. Univariate and multiple linear regression analyses were performed.


RESULTS
A total of 792 patients participated in the study (59% female, mean age 44.4 (SD 11.4), with 6-month follow-up results available from 391 patients. In univariate analysis 17 variables reached significance. In multiple linear regression identified predictors were: impairment in daily life before therapy, mental disorders, duration of the complaints, self-prognosis on work ability, rheumatoid arthritis, age, form of stress at work and physical activity. The variables explain 34% of variance (adjusted R(2), p<0.001).


CONCLUSIONS
With minimal information available from observational studies on the predictors of development of back problems for physiotherapy patients, this study adds new knowledge for forming appropriate referral guidelines. Impairment in daily life before therapy, mental disorder as comorbidity and the duration of the complaints can be named as outstanding factors. The results of this study can be used to facilitate comparison of patient therapy goals with the prognosis in everyday practice.
Prediction Games and Arcing Algorithms

The theory behind the success of adaptive reweighting and combining algorithms (arcing) such as Adaboost (Freund & Schapire, 1996a, 1997) and others in reducing generalization error has not been well understood. By formulating prediction as a game where one player makes a selection from instances in the training set and the other a convex linear combination of predictors from a finite set, existing arcing algorithms are shown to be algorithms for finding good game strategies. The minimax theorem is an essential ingredient of the convergence proofs. An arcing algorithm is described that converges to the optimal strategy. A bound on the generalization error for the combined predictors in terms of their maximum error is proven that is sharper than bounds to date. Schapire, Freund, Bartlett, and Lee (1997) offered an explanation of why Adaboost works in terms of its ability to produce generally high margins. The empirical comparison of Adaboost to the optimal arcing algorithm shows that their explanation is not complete.
Evaluation of Optimal Parameters for machining with Wire cut EDM Using Grey-Taguchi Method

The main objective of this work is to demonstrate the optimization of Wire Electrical Discharge Machining process parameters for the machining of H13 HOT DIE STEEL, with multiple responses Material Removal Rate (MRR), surface roughness (Ra) based on the Grey–Taguchi Method. taguchi’sL27(2 1 x3 8 ) Orthogonal Array was used to conduct experiments, which correspond to randomly chosen different combinations of process parameter setting, with eight process parameters: TON, TOFF, IP, SV WF, WT, SF, WP each to be varied in three different levels. Data related to the each response viz. material removal rate (MRR), surface roughness (Ra) have been measured for each experimental run; With Grey Relational Analysis Optimal levels of process parameters were identified. The relatively significant parameters were determined by Analysis of Variance. The variation of output responses with process parameters were mathematically modeled by using non-linear regression analysis. The models were checked for their adequacy. Result of confirmation experiments showed that the established mathematical models can predict the output responses with reasonable accuracy.
Suicide by prisoners. National clinical survey.

BACKGROUND
The number of suicides in prison has increased over recent years. This is the first study to describe the clinical care of a national sample of prison suicides.


AIMS
To describe the clinical and social circumstances of self-inflicted deaths among prisoners.


METHOD
A national clinical survey based on a 2-year sample of self-inflicted deaths in prisoners. Detailed clinical and social information was collected from prison governors and prison health care staff.


RESULTS
There were 172 self-inflicted deaths: 85 (49%; 95% CI 42-57) were of prisoners on remand; 55 (32%; 95% CI 25-39) occurred within 7 days of reception into prison. The commonest method was hanging or self-strangulation (92%; 95% CI 88-96). A total of 110 (72%; 95% CI 65-79) had a history of mental disorder. The commonest primary diagnosis was drug dependence (39, 27%; 95% CI 20-35). Eighty-nine (57%; 95% CI 49-64) had symptoms suggestive of mental disorder at reception into prison.


CONCLUSIONS
Suicide prevention measures should be concentrated in the period immediately following reception into prison. Because hanging is the commonest method of suicide, removal of potential ligature points from cells should be a priority.