LLukas22/scidocs huggingface dataset:
Risk of transferring malignant cells with transplanted frozen-thawed ovarian tissue.

Ovarian tissue cryopreservation and transplantation is a real option to preserve and restore fertility in young cancer patients. However, there is a concern regarding the possible presence of malignant cells in the ovarian tissue, which could lead to recurrence of the primary disease after reimplantation. A review of the existing literature was done to evaluate the risk of transplanting malignant cells in case of the main malignant indications for ovarian tissue cryopreservation. For ovarian tissue from patients with hematologic malignancies, it is of paramount importance to identify minimal residual disease before ovarian tissue transplantation. Indeed, these pathologies, reviewed here in detail, are considered to be most at risk of ovarian metastasis.
Holonic manufacturing scheduling: architecture, cooperation mechanism, and implementation

A Holonic Manufacturing System (HMS) is a manufacturing system where key elements, such as machines, cells, factories, parts, products, operators, teams, etc., are modeled as \holons" having autonomous and cooperative properties. The decentralized information structure, the distributed decision-making authority, the integration of physical and informational aspects, and the cooperative relationship among holons, make the HMS a new paradigm, with great potential for meeting today's agile manufacturing challenges. Critical issues to be investigated include how to de ne holons for a given problem context, what should be the appropriate system architecture, and how to design e ective cooperation mechanisms for good system performance. In this paper, holonic scheduling is developed for a factory consisting of multiple cells. Relevant holons are identi ed, and their relationships are delineated through a novel modeling of the interactions among parts, machines, and cells. The cooperation mechanisms among holons are established based on the pricing concept of market economy following \Lagrangian relaxation" of mathematical optimization, and cooperation across cells is performed without accessing individual cells' local information nor intruding on their decision authority. The system also possesses structural recursivity and extendibility. Numerical testing shows that the method can generate near-optimal schedules with quanti able quality in a timely fashion, and has comparable computational requirements and performance as compared to the centralized method following single-level Lagrangian relaxation. The method thus provides a theoretical foundation for guiding the cooperation among holons, leading to globally near-optimal performance.
General surgery residents' perception of robot-assisted procedures during surgical training.

INTRODUCTION
With the continued expansion of robotically assisted procedures, general surgery residents continue to receive more exposure to this new technology as part of their training. There are currently no guidelines or standardized training requirements for robot-assisted procedures during general surgical residency. The aim of this study was to assess the effect of this new technology on general surgery training from the residents' perspective.


METHODS
An anonymous, national, web-based survey was conducted on residents enrolled in general surgery training in 2013. The survey was sent to 240 Accreditation Council for Graduate Medical Education-approved general surgery training programs.


RESULTS
Overall, 64% of the responding residents were men and had an average age of 29 years. Half of the responses were from postgraduate year 1 (PGY1) and PGY2 residents, and the remainder was from the PGY3 level and above. Overall, 50% of the responses were from university training programs, 32% from university-affiliated programs, and 18% from community-based programs. More than 96% of residents noted the availability of the surgical robot system at their training institution. Overall, 63% of residents indicated that they had participated in robotic surgical cases. Most responded that they had assisted in 10 or fewer robotic cases with the most frequent activities being assisting with robotic trocar placement and docking and undocking the robot. Only 18% reported experience with operating the robotic console. More senior residents (PGY3 and above) were involved in robotic cases compared with junior residents (78% vs 48%, p < 0.001). Overall, 60% of residents indicated that they received no prior education or training before their first robotic case. Approximately 64% of residents reported that formal training in robotic surgery was important in residency training and 46% of residents indicated that robotic-assisted cases interfered with resident learning. Only 11% felt that robotic-assisted cases would replace conventional laparoscopic surgery in the future.


CONCLUSIONS
This study illustrates that although the most residents have a robot at their institution and have participated in robotic surgery cases, very few residents received formal training before participating in a robotic case.
Bivalirudin is associated with improved clinical and economic outcomes in heart failure patients undergoing percutaneous coronary intervention: Results from an observational database.

BACKGROUND
Outcomes with bivalirudin compare favorably with heparin ± GPIIb/IIIa receptor inhibition (heparin ± GPI) during percutaneous coronary intervention (PCI). Patients with congestive heart failure (CHF) have increased risk for complications. The objective was to investigate clinical and economic outcomes for bivalirudin ± GPI vs. heparin ± GPI among PCI patients with CHF.


METHODS
Using the Premier Hospital Database, PCI patients with CHF were stratified by anticoagulant: bivalirudin, bivalirudin ± GPI, heparin and heparin ± GPI. The probability of receiving bivalirudin ± GPI was estimated using individual and hospital variables. Using propensity scores, each bivalirudin ± GPI patient was matched to a heparin ± GPI patient. The primary outcome was in-hospital death. Bleeding rates, transfusion, length of stay and in-hospital cost were ascertained.


RESULTS
Overall, 116,313 patients at 315 hospitals received bivalirudin (n = 45,559) bivalirudin + GPI (n = 8,115), heparin (n = 27,972) or heparin + GPI (n = 34,667). Patients had STEMI (21.2%), NSTEMI (29.1%), unstable angina (16.6%), stable angina (5.7%) or other ischemic heart disease (24.2%). Of these, 79.1% of bivalirudin patients matched, resulting in 84,948 analyzed patients. Compared with heparin ± GPI patients, bivalirudin ± GPI patients had fewer deaths (3.3% vs. 3.9%; p < 0.0001), less clinically apparent bleeding (10.2% vs. 11.4%; p < 0.0001), clinically apparent bleeding with transfusion (2.7% vs. 3.2%, p <0.0001), and transfusion (8.5% vs. 9.8%, p < 0.0001). Patients receiving bivalirudin had shorter length of stay (6.3 vs. 6.8 days; p < 0.0001) and lower in-hospital cost (mean $26,706 vs. $27,166 [median $19,414 vs. $19,798]; p < 0.0001). In conclusion, this is the largest retrospective analysis of PCI patients with CHF and demonstrates bivalirudin ± GPI compared with heparin ± GPI is associated with lower inpatient rates of death, bleeding, and cost.
Treatment of Hypertension: Favourable Effect of the Twice-Daily Compared to the Once-Daily (Evening) Administration of Perindopril and Losartan.

BACKGROUND/AIMS
Little is known about the effect of twice daily administration of same dose of ACE inhibitor and ARB on the diurnal/nocturnal blood pressure (BP) ratio. We aimed to assess the effect of two widely used long-acting drugs: perindopril and losartan in the treatment of hypertension comparing the once-daily (evening) vs. twice-daily (morning and evening) administration with the same daily doses.


METHODS
Untreated primary hypertensive patients without complaints (a total of 164: 65 men, 99 women, 55.7 ± 13.7 years of age, 41-41 patients per treated groups) were selected with non-dipper phenomenon, estimated by diurnal index (DI) <10%. The effect of evening (8 mg perindopril or 100 mg losartan) vs morning and evening (4-4 mg perindopril or 50-50 mg losartan) administration was determined on a 14-day treatment by ABPM.


RESULTS
The mean BP, the percent time elevation index, and the hyperbaric impact decreased in both drug groups. Significant difference was observed in the DI in the case of twice-daily administration vs once-daily evening dosing.


CONCLUSIONS
The twice-daily administration with the same daily dose of perindopril or losartan seems to be more effective compared to the once daily evening administration in eliminating the non-dipper phenomenon. According to some authors the non-dipping phenomenon increases cardiovascular risk, while others are of the opinion that the association of non-dipping with cardiovascular events does not necessarily mean that selective treatment of non-dipping improves cardiovascular outcomes.
A comparative study on two types of transparent patch antennas

Properties of optically transparent patch antennas designed from meshed conductor and transparent conductive films are studied and compared. It is shown that at S band, meshed antenna provides the best antenna efficiency for the highest transparency. It is practical to design a 90% transparent meshed antenna with more than 60% transparency. Indium tin oxide (ITO) films, although less visible to human eyes than conductive meshes, at an optical transparency of 80%, provide an antenna efficiency of less than 30% at 2.5 GHz. AgHT (silver coated polyester film) film has lower transparency compared to ITO films for the same antenna efficiency. It is also shown that with the progress in material processing, the efficiency of an ITO patch antenna can be improved to be comparable to a meshed one. In addition, one can improve the efficiency of an antenna designed from ITO films by increasing the operational frequency.
Poverty and Productivity in Female-Headed Households in Zimbabwe

A household survey conducted in rural Zimbabwe in 2001 is used to compare the position of de facto and de jure female-headed households to those with a male head. These households are characterised by different forms of poverty that impinge on their ability to improve agricultural productivity. However, once inputs are accounted for, it is only for growing cotton that femaleheaded households’ productivity is lower than that found for male-headed households. General poverty alleviation policies will benefit the female-headed household but specific interventions via extension services and access to marketing consortia are also indicated. JEL classification: O12
ParaDock: a flexible non-specific DNA—rigid protein docking algorithm

Accurate prediction of protein-DNA complexes could provide an important stepping stone towards a thorough comprehension of vital intracellular processes. Few attempts were made to tackle this issue, focusing on binding patch prediction, protein function classification and distance constraints-based docking. We introduce ParaDock: a novel ab initio protein-DNA docking algorithm. ParaDock combines short DNA fragments, which have been rigidly docked to the protein based on geometric complementarity, to create bent planar DNA molecules of arbitrary sequence. Our algorithm was tested on the bound and unbound targets of a protein-DNA benchmark comprised of 47 complexes. With neither addressing protein flexibility, nor applying any refinement procedure, CAPRI acceptable solutions were obtained among the 10 top ranked hypotheses in 83% of the bound complexes, and 70% of the unbound. Without requiring prior knowledge of DNA length and sequence, and within <2 h per target on a standard 2.0 GHz single processor CPU, ParaDock offers a fast ab initio docking solution.
New diagnostic criteria and severity assessment of acute cholangitis in revised Tokyo guidelines

BACKGROUND
The Tokyo Guidelines for the management of acute cholangitis and cholecystitis were published in 2007 (TG07) and have been widely cited in the world literature. Because of new information that has been published since 2007, we organized the Tokyo Guidelines Revision Committee to conduct a multicenter analysis to develop the updated Tokyo Guidelines (TG13).


METHODS/MATERIALS
We retrospectively analyzed 1,432 biliary disease cases where acute cholangitis was suspected. The cases were collected from multiple tertiary care centers in Japan. The 'gold standard' for acute cholangitis in this study was that one of the three following conditions was present: (1) purulent bile was observed; (2) clinical remission following bile duct drainage; or (3) remission was achieved by antibacterial therapy alone, in patients in whom the only site of infection was the biliary tree. Comparisons were made for the validity of each diagnostic criterion among TG13, TG07 and Charcot's triad.


RESULTS
The major changes in diagnostic criteria of TG07 were re-arrangement of the diagnostic items and exclusion of abdominal pain from the diagnostic list. The sensitivity improved from 82.8 % (TG07) to 91.8 % (TG13). While the specificity was similar to TG07, the false positive rate in cases of acute cholecystitis was reduced from 15.5 to 5.9 %. The sensitivity of Charcot's triad was only 26.4 % but the specificity was 95.6 %. However, the false positive rate in cases of acute cholecystitis was 11.9 % and not negligible. As for severity grading, Grade II (moderate) acute cholangitis is defined as being associated with any two of the significant prognostic factors which were derived from evidence presented recently in the literature. The factors chosen allow severity assessment to be performed soon after diagnosis of acute cholangitis.


CONCLUSION
TG13 present a new standard for the diagnosis, severity grading, and management of acute cholangitis.
Antecedents and consequences of mobile phone usability: Linking simplicity and interactivity to satisfaction, trust, and brand loyalty

Usability is a central issue for mobile phone design and service because users need to access various functionalities via limited user interfaces (UI) often while they are on the road. In this paper, we propose simplicity and interactivity as the key determinants of mobile phone usability and assess their significance in an empirical setting. Furthermore, we examine the effects of mobile phone usability on user satisfaction, trust, and brand loyalty and provide a holistic view of the causal relationships between the proposed UI features and important organizational variables for building and maintaining long-term customer relationships. The study was conducted using survey questionnaire data collected from 310 mobile phone users in South Korea. The findings of the study confirm that simplicity and interactivity are two significant determinants of mobile phone usability and that interface simplicity is an important precondition for positive interactivity and usability experience. Our findings also show that usability is a distal determinant of brand loyalty, exerting its influence indirectly through the mediators of satisfaction and trust. We discuss the implications of the study findings for usability research and UI design. 2014 Elsevier B.V. All rights reserved. * Corresponding author at: Seoul National University, 8203A, Bd. 200, Gwanangno 599, Gwanak-gu, Seoul 151-921, Republic of Korea. Tel.: +82 2 880 4722; fax: +82 2 873 5080. E-mail addresses: dongwon.lee@rhsmith.umd.edu (D. Lee), moonj@snu.ac.kr (J. Moon), yongjkim@sogang.ac.kr (Y.J. Kim), munyi@kaist.ac.kr (M.Y. Yi).
Development of a Practical ERP Pre – Implementation Assessment Model for Organisations in Tanzania

1, 2,3, 4 University of Dar es salaam, College of Engineering and Technology, Department of Mechanical and Industrial Engineering, Dar es Salaam, Tanzania ---------------------------------------------------------------------***--------------------------------------------------------------------Abstract Tanzanian organisations faces challenges associated with ERP implementation in order to fully benefits from technology in terms of improved productivity, competitiveness and efficiency. However, implementation of ERP systems in developing countries is complicated, costly and challenges related to business -Information technology alignment. This paper proposes a practical model for assessment of pre-implementation of an enterprise in Tanzania prior to implementation of ERP system. Finally, the researchers conclude on the position of pre-implementation assessment towards successful implementation of ERP system in an organization.
Efficient and non-parametric reasoning over user preferences

We consider the problem of modeling and reasoning about statements of ordinal preferences expressed by a user, such as monadic statement like “X is good,” dyadic statements like “X is better than Y,” etc. Such qualitative statements may be explicitly expressed by the user, or may be inferred from observable user behavior. This paper presents a novel technique for efficient reasoning about sets of such preference statements in a semantically rigorous manner. Specifically, we propose a novel approach for generating an ordinal utility function from a set of qualitative preference statements, drawing upon techniques from knowledge representation and machine learning. We provide theoretical evidence that the new method provides an efficient and expressive tool for reasoning about ordinal user preferences. Empirical results further confirm that the new method is effective on real-world data, making it promising for a wide spectrum of applications that require modeling and reasoning about user preferences.
Experimental verification of the feasibility of a quantum channel between space and Earth

Extending quantum communication to Space environments would enable to perform fundamental experiments on quantum physics as well as applications of quantum information at planetary and interplanetary scales. Here, we report the first experimental implementation of a scheme for single-photon exchange between a satellite and an Earth-based station. We built an experiment that mimics a single photon source on a satellite, exploiting the telescope at the Matera Laser Ranging Observatory of the Italian Space Agency to detect the transmitted photons. Weak laser pulses, emitted by the ground-based station, are directed towards a satellite equipped with cube-corner retroreflectors. These reflect a small portion of the pulse, with an average of less-than-one photon per pulse directed to our receiver, as required for the faint-pulse quantum communication. We were able to detect returns from satellite Ajisai, a low-earth orbit geodetic satellite, whose orbit has a perigee height of 1485 km. PACS: 03.67.Hk Quantum communication, 07.87.+v Spaceborne and space research instruments, apparatus, and components.
Advanced Message Queuing Protocol

The advanced message queuing protocol (AMQP) working group's goal is to create an open standard for an interoperable enterprise-scale asynchronous messaging protocol. AMQP is finally addressing the lack of enterprise messaging interoperability standards. This relatively simple yet compellingly powerful enterprise messaging protocol is thus poised to open up a bright new era for enterprise messaging
Will early reconstruction prevent abnormal kinematics after ACL injury? Two-year follow-up using dynamic radiostereometry in 14 patients operated with hamstring autografts

Previous studies have reported that Anterior Cruciate Ligament (ACL) reconstruction does not restore normal tibial rotation in patients with chronic instability and repeated episodes of giving way. We hypothesised that early ACL reconstruction, using quadruple hamstring autografts, before the pivoting episodes had occurred, would protect the knee joint from developing abnormal kinematics with increased external tibial rotation during flexion. Fourteen consecutive patients (8 men, 6 women) with a median age of 24 years (18–43), with a complete, isolated unilateral ACL rupture and an intact contralateral knee, were studied. The operations were performed by one experienced surgeon, using quadruple hamstring autografts. We used dynamic radiostereometry (RSA) with tantalum markers inserted in both the injured and the intact contralateral knee to study the pattern of knee motion during active and weight-bearing knee extension. The patients were evaluated pre-operatively and followed for 2 years after the ACL reconstruction. The anterior-posterior laxity was measured using the KT-1000. Before surgical repair of the ACL, the internal/external tibial rotation or abduction/adduction did not differ significantly between the injured and intact knees (P = 0.27–0.91). Separate studies of the anterior-posterior translation of the medial and lateral femoral flexion facet centres (MFC and LFC) relative to a fixed tibia did not reveal any significant differences between the injured and intact knees (P = 0.21–0.59). Pre-operatively, the KT-1000 laxity measurements showed a side-to-side difference of 2.5 (1.0–5.5) mm. At 2 years, the laxity side-to-side difference was 0.5 (0–3.0) mm (P = 0.001), and there were still no significant differences between the injured and intact knees in terms of internal/external tibial rotation and abduction/adduction (P = 0.13–0.60). Nor did the anterior-posterior translation of the flexion facet centres differs (P = 0.27–0.97). During the first 6–8 weeks after the ACL injury, before pivoting episodes had occurred, the kinematics of the injured knee were normal and did not differ from those of the intact contralateral knee. Reconstruction of the ACL within 10 weeks after injury using quadruple hamstring autografts resulted in unchanged knee kinematics for 2 years and no difference compared with the intact contralateral knee. Surgical repair during the early phase after the injury appears to protect the knee from developing abnormal knee motion after an ACL rupture. III.
Current practice in measuring usability: Challenges to usability studies and research

How to measure usability is an important question in HCI research and user interface evaluation. We review current practice in measuring usability by categorizing and discussing usability measures from 180 studies published in core HCI journals and proceedings. The discussion distinguish several problems with the measures, including whether they actually measure usability, if they cover usability broadly, how they are reasoned about, and if they meet recommendations on how to measure usability. In many studies, the choice of and reasoning about usability measures fall short of a valid and reliable account of usability as quality-in-use of the user interface being studied. Based on the review, we discuss challenges for studies of usability and for research into how to measure usability. The challenges are to distinguish and empirically compare subjective and objective measures of usability; to focus on developing and employing measures of learning and retention; to study long-term use and usability; to extend measures of satisfaction beyond post-use questionnaires; to validate and standardize the host of subjective satisfaction questionnaires used; to study correlations between usability measures as a means for validation; and to use both micro and macro tasks and corresponding measures of usability. In conclusion, we argue that increased attention to the problems identified and challenges discussed may strengthen studies of usability and usability research. r 2005 Elsevier Ltd. All rights reserved.