LLukas22/scidocs huggingface dataset:
Virtual Reality for Industrial Applications

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Intravenous paracetamol as adjunctive treatment for postoperative pain after cardiac surgery: a double blind randomized controlled trial.

BACKGROUND
Nonsteroidal anti-inflammatory drugs and opioids are routinely used after cardiac surgery in order to mitigate postoperative pain; however, these drugs are burdened by side effects. Tramadol and paracetamol are believed to be lacking in such side effects. The aim of this study was to examine the efficacy of intravenous paracetamol as an adjunctive analgesic to a tramadol-based background analgesia after cardiac surgery.


METHODS
A total of 113 patients participated in this single center, placebo-controlled, double-blind, randomized trial. Fifty-six patients were randomized to receive paracetamol and 57 to placebo. Intravenous study drug (1 g) was administered 15 min before the end of surgery and every 6h for 72 h. Standard analgesia (tramadol) and anti-emetic prophylactic regimen (ondansetron) were available to both patient groups. Postoperative pain was evaluated by visual analog scale, and it was measured at rest and during a deep breath. A rescue dose of 2-5 mg of intravenous morphine was administered whenever the VAS score was greater than 3.


RESULTS
Baseline characteristics were equivalent between the two groups. At 12, 18, 24 h after the end of operation, patients who received paracetamol had significantly less pain at rest (p=0.0041, 0.0039, 0.0044, respectively); after this time the two groups did not differ. During a deep breath the difference was significant only at 12 h (p=0.0040). Paracetamol group required less cumulative morphine than placebo group (48 mg vs 97 mg) even if the difference did not reach statistical significance (p=0.274).


CONCLUSIONS
In patients undergoing cardiac surgery, intravenous paracetamol in combination with tramadol provides effective pain control.
John McCarthy's legacy

This special issue is dedicated to John McCarthy, founding father of Artificial Intelligence. It contains a collection of recent contributions to the field of knowledge representation and reasoning, a field that McCarthy founded and that has been a main focus of his research during the last half century. In this introductory article, we survey some of McCarthy's major contributions to the field of knowledge representation and reasoning, and situate the papers in this special issue in the context of McCarthy's previous work.
Prevalence and clinical significance of the MYD88 (L265P) somatic mutation in Waldenstrom's macroglobulinemia and related lymphoid neoplasms.

A study has shown that MYD88 (L265P) is a recurring somatic mutation in Waldenström's macroglobulinemia (WM). We developed an allele-specific polymerase chain reaction (PCR) for this mutation, and analyzed bone marrow or peripheral blood samples from 58 patients with WM, 77 with IgM monoclonal gammopathy of undetermined significance (IgM-MGUS), 84 with splenic marginal zone lymphoma (SMZL), and 52 with B-cell chronic lymphoproliferative disorders (B-CLPD). MYD88 (L265P) was detected in 58/58 (100%) patients with WM, 36/77 (47%) with IgM-MGUS, 5/84 (6%) with SMZL, and 3/52 (4%) with B-CLPD. Compared to IgM-MGUS patients with wild-type MYD88, those carrying MYD88 (L265P) showed significantly higher levels of IgM (P < .0001) and presented Bence-Jones proteinuria more frequently at diagnosis (P = .002). During follow-up, 9 patients with IgM-MGUS progressed to WM or to marginal zone lymphoma. Using a case-control approach, the risk of evolution of patients carrying MYD88 (L265P) was significantly higher than that of patients with wild-type MYD88 (odds ratio 4.7, 95% confidence interval 0.8 to 48.7, P = .047). These findings indicate that the allele-specific PCR we developed is a useful diagnostic tool for patients with WM or IgM-MGUS. In this latter condition, MYD88 (L265P) is associated with greater disease burden and higher risk of disease progression, and the mutation may therefore also represent a useful prognostic marker.
A randomised controlled trial of induced hypermagnesaemia following aneurysmal subarachnoid haemorrhage.

BACKGROUND
The effect of serum magnesium concentration on the incidence of cerebral arterial vasospasm following aneurysmal subarachnoid haemorrhage (SAH) is unclear.


OBJECTIVE
To test whether induced hypermagnesaemia reduces the incidence of cerebral arterial vasospasm following aneurysmal SAH.


METHODS
The study was conducted at two tertiary hospitals in Australia and patients were recruited between 1 April 2005 and 31 December 2009. Within 72 hours of aneurysmal SAH, patients were randomly assigned to a high or normal target for serum magnesium concentration (1.60-2.50 mmol/L or 0.65-1.05 mmol/L, respectively). The primary end point was cerebral arterial vasospasm diagnosed by blinded assessment of digital subtraction angiography. Secondary outcomes included severity of vasospasm and functional recovery at 90 days. Analysis was by intention to treat.


RESULTS
Of 162 patients, 81 were assigned to the normal range group and 81 were assigned to the high-range group; the primary outcome was available for 78 and 79 patients, respectively. The groups had similar baseline characteristics. Vasospasm occurred in 40 patients (50.6%) and 50 patients (64.1%) assigned to high-range and normal-range groups, respectively (adjusted OR, 0.51; 95% CI, 0.26-1.02; P = 0.06). At 90 days, neurological recovery between the groups was not significantly different (adjusted OR for worse outcome, 0.71; 95% CI, 0.39-1.32; P = 0.28). Patients in the high-range group were treated with more noradrenaline to support arterial blood pressure (79 [16- 218] mg) v 59 [14-129] mg; P = 0.03) and had lower mean (SD) serum calcium concentration (1.9 [0.2] mmol/L v 2.1 [0.2] mmol/L, P < 0.001).


CONCLUSION
Patients assigned a higher serum magnesium concentration had a reduced incidence of vasospasm as seen by angiography, but the difference was not statistically significant. Clinically significant outcomes were not different between groups. A firm recommendation for induced hypermagnesaemia cannot be made from this study.


TRIAL REGISTRATION NUMBER
ACTRN12605000058673.
Association between acquired rifamycin resistance and the pharmacokinetics of rifabutin and isoniazid among patients with HIV and tuberculosis.

BACKGROUND
The occurrence of acquired rifamycin resistance despite use of directly observed therapy for tuberculosis is associated with advanced human immunodeficiency virus (HIV) disease and highly intermittent administration of antituberculosis drugs. Beyond these associations, the pathogenesis of acquired rifamycin resistance is unknown.


METHODS
We performed a pharmacokinetic substudy of patients in a trial of treatment with twice-weekly rifabutin and isoniazid.


RESULTS
A total of 102 (60%) of 169 patients in the treatment trial participated in the pharmacokinetic substudy, including 7 of 8 patients in whom tuberculosis treatment failure or relapse occurred in association with acquired rifamycin-resistant mycobacteria (hereafter, "ARR failure or relapse"). The median rifabutin area under the concentration-time curve (AUC(0-24)) was lower for patients with than for patients without ARR failure or relapse (3.3 vs. 5.2 microg*h/mL; P = .06, by the Mann-Whitney exact test). In a multivariate analysis adjusted for CD4+ T cell count, the mean rifabutin AUC(0-24) was significantly lower for patients with ARR failure or relapse than for other patients (3.0 microg*h/mL [95% confidence interval {CI}, 1.9-4.5] vs. 5.2 microg*h/mL [95% CI, 4.6-5.8]; P = .02, by analysis of covariance). The median isoniazid AUC(0-12) was not significantly associated with ARR failure or relapse (20.6 vs. 28.0 microg*h/mL; P = .24, by the Mann-Whitney exact test). However, in a multivariate logistic regression model that adjusted for the rifabutin AUC(0-24), a lower isoniazid AUC(0-12) was associated with ARR failure or relapse (OR, 10.5; 95% CI, 1.1-100; P = .04).


CONCLUSIONS
Lower plasma concentrations of rifabutin and, perhaps, isoniazid were associated with ARR failure or relapse in patients with tuberculosis and HIV infection treated with twice-weekly therapy.
The challenge of maximizing safety in radiation oncology.

There is a growing interest in the evolving nature of safety challenges in radiation oncology. Understandably, there has been a great deal of focus on the mechanical and computer aspects of new high-technology treatments (eg, intensity-modulated radiation therapy). However, safety concerns are not limited to dose calculations and data transfer associated with advanced technologies. They also stem from fundamental changes in our workflow (eg, multiple hand-offs), the relative loss of some traditional "end of the line" quality assurance tools (port films and light fields), condensed fractionation schedules, and an under-appreciation for the physical limitations of new techniques. Furthermore, changes in our workspace and tools (eg, electronic records, planning systems), and workloads (eg, billing, insurance, regulations) may have unforeseen effects on safety. Safety initiatives need to acknowledge the multiple factors affecting risk. Our current challenges will not be adequately addressed simply by defining new policies and procedures. Rather, we need to understand the frequency and causes of errors better, particularly those that are most likely to cause harm. Then we can incorporate principles into our workspace that minimize these risks (eg, automation, standardization, checklists, redundancy, and consideration of "human factors" in the design of products and workspaces). Opportunities to enhance safety involve providing support through diligent examinations of staffing, schedules, communications, teamwork, and work environments. We need to develop a culture of safety in which all team members are alerted to the possibility of harm, and they all work together to maximize safety. The goal is not to eliminate every error. Rather, we should focus our attention on conditions (eg, rushing) that can cause real patient harm, and/or those conditions that reflect systemic problems that might lead to errors more likely to cause harm. Ongoing changes in clinical practice mandate continued vigilance to minimize the risks of error, combined with new, nontraditional approaches to create a safer patient environment.
Assisted partner notification services to augment HIV testing and linkage to care in Kenya: study protocol for a cluster randomized trial

BACKGROUND
HIV case-finding and linkage to care are critical for control of HIV transmission. In Kenya, >50% of seropositive individuals are unaware of their status. Assisted partner notification is a public health strategy that provides HIV testing to individuals with sexual exposure to HIV and are at risk of infection and disease. This parallel, cluster-randomized controlled trial will evaluate the effectiveness, cost-effectiveness, and feasibility of implementing HIV assisted partner notification services at HIV testing sites (clusters) in Kenya.


METHODS/DESIGN
Eighteen sites were selected among health facilities in Kenya with well-established, high-volume HIV testing programs, to reflect diverse communities and health-care settings. Restricted randomization was used to balance site characteristics between study arms (n = 9 per arm). Sixty individuals testing HIV positive ('index partners') will be enrolled per site (inclusion criteria: ≥18 years, positive HIV test at a study site, willing to disclose sexual partners, and never enrolled for HIV care; exclusion criteria: pregnancy or high risk of intimate partner violence). Index partners provide names and contact information for all sexual partners in the past 3 years. At intervention sites, study staff immediately contact sexual partners to notify them of exposure, offer HIV testing, and link to care if HIV seropositive. At control sites, passive partner referral is performed according to national guidelines, and assisted partner notification is delayed by 6 weeks. Primary outcomes, assessed 6 weeks after index partner enrollment and analyzed at the cluster level, are the number of partners accepting HIV testing and number of HIV infections diagnosed and linked to care per index partner. Secondary outcomes are the incremental cost-effectiveness of partner notification and the costs of identifying >1 partner per index case. Participants are closely monitored for adverse outcomes, particularly intimate partner violence. The study is unblinded due to practical limitations.


DISCUSSION
This rigorously designed trial will inform policy decisions regarding implementation of HIV partner notification services in Kenya, with possible application to other parts of sub-Saharan Africa. Examination of effectiveness and cost-effectiveness in diverse settings will enable targeted application and define best practices.


TRIAL REGISTRATION
ClinicalTrials.gov NCT01616420 .
Parallel Computing Experiences with CUDA

The CUDA programming model provides a straightforward means of describing inherently parallel computations, and NVIDIA's Tesla GPU architecture delivers high computational throughput on massively parallel problems. This article surveys experiences gained in applying CUDA to a diverse set of problems and the parallel speedups over sequential codes running on traditional CPU architectures attained by executing key computations on the GPU.
Security for Automated , Distributed Configuration Management

Installation, configuration, and administration of desktop software is a non-trivial process. Even a simple application can have numerous dependencies on hardware, device drivers, operating system versions, dynamically linked libraries, and even on other applications. These dependencies can cause surprising failures during the normal process of installations, updates and re-configurations. Diagnosing and resolving such failures involves detailed knowledge of the hardware and software installed in the machine, configuration manifests of particular applications, version incompatibilities, etc. This is usually too hard for end-users, and even for technical support personnel, specially in small businesses. It may be necessary to involve software vendors and outside consultants or laboratories. Employees working on sensitive, proprietary projects may even have to resort to calling the help line of an application vendor and discussing details of their desktop configuration. In order establish valid licensing, the user may be forced to disclose additional details such as the user’s identity, machine identification, software serial number, etc. This type of disclosure may reveal proprietary information or (worse) security vulnerabilities, and increase the risk of attack by hackers or cyber-criminals. An adequate solution to the distributed configuration management problem needs to address the security concerns of users, administrators, software vendors and outside consultants: keeping details of installations private, authenticating licensed users and software vendors, protecting the integrity of software, secure delegation across administrative boundaries, and protecting proprietary information. Existing commercial and research systems [12, 8] provide distributed configuration management by distributing configuration information and software over local and wide-area networks. They provide flexible, automated, distributed configuration management. However, many or most of the security issues listed above remain to be addressed. These issues are the central focus of our research. ∗Address for the first two authors: Dept. of Computer Science, Room 2063, Engineering Unit II, Davis, CA 95616. Last author: CertCo Inc., 55 Broad St., Suite 22, New York City, NY 10004
Using short message service to encourage interactivity in the classroom

Interactivity in the classroom is reported to promote a more active learning environment, facilitate the building of learning communities, provide greater feedback for lecturers, and help student motivation. Various definitions of interactivity exist in the literature, alternately focusing on the participants, structure and technology. The PLS TXT UR Thoughts research project builds on existing definitions to define interactivity as a message loop originating from and concluding with the student. The authors chose to introduce mobile phones and short message service (SMS) within the classroom due to the ubiquity of mobile phones among students and the interactive potential of SMS. SMS is a low-threshold application used widely by students to quickly send concise, text-based messages at any time. The research presented involved students sending SMS in real-time, in class, via their personal mobile phones. Using a modem interfacing with customised software to produce SMS files, the lecturer can view the messages and verbally develop the interactive loop with students during class. The SMS are available online after class, allowing interactive loops to further develop via threaded comments. 2005 Elsevier Ltd. All rights reserved.
Combining Internal Probing with Artificial Neural Networks for Optimal RFIC Testing

In order to reduce production costs of RF devices, it is important to remove bad circuits very early in the production flow. It is all the more true for dies designed to be integrated in complex systems. Thus highly efficient RF wafer testing is mandatory for those applications to prevent the loss of assembled systems due to defective RF dies. The problem is that current RF probing technologies hardly fulfil the industrial test requirements in terms of accuracy, reliability and cost. The proposed method proves to be a very interesting alternative to validate RF parameters with no need of expensive RF equipments (RF probes and RF automated test equipments (ATE)). A new test strategy based on DC or very low frequency (LF) measurements, which allows the elimination of expensive RF tests, is presented. The main idea is to insert some simple design for test (DfT) circuitry within the chip. This DfT provides relevant information on the structural behavior of the device blocks. The internal node data are additional to standard DC test measurements like power supply current or advanced DC test signatures (e.g. Vdd ramping), and LF measurements like gain in loopback mode. Since RF performance of each block is directly related to such structural data, it is possible to predict the RF characteristics of the blocks without time consuming RF measurements. RF parameters estimation is performed using nonlinear artificial neural networks
Manipulation Planning with Probabilistic Roadmaps

This paper deals with motion planning for robots manipulating movable objects among obstacles. We propose a general manipulation planning approach capable of addressing continuous sets for modeling both the possible grasps and the stable placements of the movable object, rather than discrete sets generally assumed by the previous approaches. The proposed algorithm relies on a topological property that characterizes the existence of solutions in the subspace of configurations where the robot grasps the object placed at a stable position. It allows us to devise a manipulation planner that captures in a probabilistic roadmap the connectivity of sub-dimensional manifolds of the composite configuration space. Experiments conducted with the planner in simulated environments demonstrate its efficacy to solve complex manipulation problems. KEY WORDS—manipulation task planning, path planning, probabilistic roadmaps
A readout system for pellistors with pulsed thermal feedback

Catalytic flammable gas sensors are used for safety in places where the accumulation of flammable gasses can generate a blast. These devices measure the flammable gas concentration via the heat produced by the catalysis of the gas by a heated catalytic coating. We propose the design and implementation of a readout system based on feedback heat pulses. In the proposed system, the heat of catalysis is directly measured via its compensation by a controlled feedback heat power. Contrary to that proposed sensor operation, previous potentiometric schemes would measure a sensor temperature increase resulting from the heat of catalysis. This proposed readout scheme for so-called “pellistor” sensors is expected to improve the measurement performance while providing a simpler implementation than previous systems.
Cost-effectiveness of internet and telephone treatment for smoking cessation: an economic evaluation of The iQUITT Study.

BACKGROUND
Internet and telephone treatments for smoking cessation can reach large numbers of smokers. There is little research on their costs and the impact of adherence on costs and effects.


OBJECTIVE
To conduct an economic evaluation of The iQUITT Study, a randomised trial comparing Basic Internet, Enhanced Internet and Enhanced Internet plus telephone counselling ('Phone') at 3, 6, 12 and 18 months.


METHODS
We used a payer perspective to evaluate the average and incremental cost per quitter of the three interventions using intention-to-treat analysis of 30-day single-point prevalence and multiple-point prevalence (MPP) abstinence rates. We also examined results based on adherence. Costs included commercial charges for each intervention. Discounting was not included given the short time horizon.


RESULTS
Basic Internet had the lowest cost per quitter at all time points. In the analysis of incremental costs per additional quitter, Enhanced Internet+Phone was the most cost-effective using both single and MPP abstinence metrics. As adherence increased, the cost per quitter dropped across all arms. Costs per quitter were lowest among participants who used the 'optimal' level of each intervention, with an average cost per quitter at 3 months of US$7 for Basic Internet, US$164 for Enhanced Internet and US$346 for Enhanced Internet+Phone.


CONCLUSIONS
'Optimal' adherence to internet and combined internet and telephone interventions yields the highest number of quitters at the lowest cost. Cost-effective means of ensuring adherence to such evidence-based programmes could maximise their population-level impact on smoking prevalence.