LLukas22/scidocs huggingface dataset:
Data routing strategies in opportunistic mobile social networks: Taxonomy and open challenges

Opportunistic Mobile Social Network (MSN) is a kind of Delay Tolerant Network (DTN) in which nodes are mobile with social characteristics. Users in such network carry data, move and forward it to others for information dissemination. To enable efficient data routing in opportunistic MSNs, the social metrics of users, such as mobility pattern, social centrality, community and etc. are leveraged in context of MSNs. In this paper, we investigate the data routing strategies in opportunistic MSNs in the following aspects: (1) the architecture of MSNs and its routing challenges and (2) routing strategies investigation on the basis of different social metrics. We study opportunistic MSN architecture and investigate the social metrics from encounter, social features and social properties, respectively. We show that encounter information is important exemplification of social metrics in opportunistic MSNs. We present other social metrics such as social features and social properties, including social graph properties and community structure. We then elaborate the routing strategies from different perspectives accordingly: encounter-based routing strategies, routing schemes according to social features and routing strategies based on social properties. We discuss the open issues for data routing in opportunistic MSNs, including limitations of routing metrics, collection of social information, social privacy and security, future applications of opportunistic MSNs, and etc. © 2015 Published by Elsevier B.V.
Induction of a chronic disease state in patients with smoldering or indolent multiple myeloma by targeting interleukin 1{beta}-induced interleukin 6 production and the myeloma proliferative component.

OBJECTIVE
To conduct in vitro studies as well as a phase 2 clinical trial in patients with smoldering or indolent multiple myeloma to determine if interleukin 1 (IL-1) inhibitors can delay or prevent active myeloma.


PATIENTS AND METHODS
Stromal cells were cocultured with IL-1beta-expressing myeloma cells in the presence of dexamethasone, IL-1 receptor antagonist (IL-1Ra), or both. Levels of interleukin 6 (IL-6) and of apoptosis were also quantified. Between November 19, 2002, and May 24, 2007, 47 patients were enrolled in the study and subsequently treated with IL-1Ra. In 25 (53%) of the 47 study patients, low-dose dexamethasone (20 mg/wk) was added. The primary end point was progression-free survival (PFS).


RESULTS
In vitro, IL-1Ra was superior to dexamethasone at inhibiting IL-6 production; maximal IL-6 inhibition and apoptosis induction were achieved by addition of both IL-1Ra and dexamethasone. In the clinical trial, 3 patients achieved a minor response to IL-1Ra alone; 5 patients achieved a partial response and 4 patients a minor response after addition of dexamethasone. Seven patients showed a decrease in the plasma cell labeling index that paralleled a decrease in high-sensitivity C-reactive protein (hs-CRP) levels. The median overall PFS was 37.5 months. The median PFS for patients without (n=12) or with (n=35) a greater than 15% decrease in 6-month vs baseline hs-CRP levels was 6 months and more than 3 years, respectively (P=.002). Disease stability was maintained in 8 patients who received therapy for more than 4 years.


CONCLUSION
In patients with smoldering or indolent multiple myeloma who were at risk of progression to active myeloma, treatment with IL-1 inhibitors decreased the myeloma proliferative rate and hs-CRP levels in those who responded, leading to a chronic disease state and an improved PFS.


TRIAL REGISTRATION
clinicaltrials.gov identifier: NCT00635154.
MultiLogo: A Study of Children and Concurrent Programming

During the past decade, computer scientists have developed dozens of concurrent (or parallel) programming languages. These languages hold the promise of opening up exciting new applications for computers. But that will happen only if people can effectively learn, use, and understand these new languages. To explore these issues, I developed a concurrent extension to Logo (called MultiLogo), and conducted an experimental study with a group of elementary school students. The students used MultiLogo to control simple robotic devices built out of LEGO bricks. In analyzing the children's work, I developed three primary categories of MultiLogo programming bugs: problem-decomposition bugs, synchronization bugs, and object-oriented bugs. Based on the results, I recommend ways to improve the design and teaching of concurrent programming languages for nonexperts.
Imaging pelvic floor disorders: trend toward comprehensive MRI.

OBJECTIVE
The purpose of this article is to review the relevant anatomy and sonographic, fluoroscopic, and MRI options for evaluating patients with pelvic floor disorders.


CONCLUSION
Disorders of the pelvic floor are a heterogeneous and complex group of problems. Imaging can help elucidate the presence and extent of pelvic floor abnormalities. MRI is particularly well suited for global pelvic floor assessment including pelvic organ prolapse, defecatory function, and pelvic floor support structure integrity.
Investigations on the effects of friction modeling in finite element simulation of machining

Accurately predicting the physical cutting process variables, e.g. temperature, velocity, strain and stress fields, plays a pivotal role for predictive process engineering for machining processes. These predicted field variables, however, are highly influenced by workpiece constitutive material model (i.e. flow stress), thermo-mechanical properties and contact friction law at the tool–chip–workpiece interfaces. This paper aims to investigate effects of friction modeling at the tool–chip–workpiece interfaces on chip formation process in predicting forces, temperatures and other field variables such as normal stress and shear stress on the tool by using advanced finite element (FE) simulation techniques. For this purpose, two distinct FE models with Arbitrary Lagrangian Eulerian (ALE) fully coupled thermal-stress analyses are employed to study not only the effects of FE modeling with different ALE techniques but also to investigate the influence of limiting shear stress at the tool–chip contact on frictional conditions, which was never done before. A detailed friction modeling at the tool–chip and tool–work interfaces is also carried by coupling sticking and sliding frictions. Experiments and simulations have been performed for machining of AISI 4340 steel using tungsten carbide tooling and the simulation results under increasing limit shear stress have been compared to experiments. The influence of limiting shear stress on the tool–chip contact friction was explored and validity of friction modeling approaches was examined. The results presented in this work not only provide a clear understanding of friction in FEM modeling of machining but also advance the process knowledge in
Entrapment Neuropathies in the Upper and Lower Limbs: Anatomy and MRI Features

Peripheral nerve entrapment occurs at specific anatomic locations. Familiarity with the anatomy and the magnetic resonance imaging (MRI) features of nerve entrapment syndromes is important for accurate diagnosis and early treatment of entrapment neuropathies. The purpose of this paper is to illustrate the normal anatomy of peripheral nerves in the upper and lower limbs and to review the MRI features of common disorders affecting the peripheral nerves, both compressive/entrapment and noncompressive, involving the suprascapular nerve, the axillary nerve, the radial nerve, the ulnar nerve, and the median verve in the upper limb and the sciatic nerve, the common peroneal nerve, the tibial nerve, and the interdigital nerves in the lower limb.
Longitudinal immune monitoring of patients receiving intratumoral injection of a MART-1 T-cell receptor-transduced cell line (C-Cure 709).

BACKGROUND AIMS
Adoptive transfer of tumor-specific lymphocytes is a promising strategy in the treatment of cancer. We conducted intratumoral administration of an allogeneic irradiated continuous T-cell line (C-Cure 709) expressing an HLA-A2-restricted MART-1-specific T-cell receptor (TCR) into HLA-A2(+) melanoma patients. The C-Cure 709 cell line is cytotoxic against MART-1(+) HLA-A2(+) melanoma cell lines and secretes several immune stimulatory cytokines upon stimulation.


METHODS
Anti-tumor immune responses against the commonly expressed tumor antigen (Ag) MART-1 were longitudinally analyzed in peripheral blood by fluorescence-activated cell sorting (FACS) before and after intratumoral injection of C-Cure 709.


RESULTS
No treatment-induced increase in Ag-specific T-cell frequencies was observed in peripheral blood, and the phenotype of MART-1-specific T cells was very stable during the treatment. Interestingly, despite a very stable frequency of MART-1-specific T cells over the course of treatment, clonotype mapping revealed that the response was in fact highly diverse and dynamic, with new clonotypes emerging during treatment. Only a few clonotypes were recurrently detected in consecutive samples. One MART-1-specific T-cell clone disappearing from peripheral blood was later detected in a metastatic lesion.


CONCLUSIONS
Sequence analyzes of the CDR3 region revealed conserved structural characteristics in the MART-1-specific TCR used by T-cell clones.
Bilingual language learning: An ERP study relating early brain responses to speech, language input, and later word production

Research on the development of speech processing in bilingual children has typically implemented a cross-sectional design and relied on behavioral measures. The present study is the first to explore brain measures within a longitudinal study of this population. We report results from the first phase of data analysis in a longitudinal study exploring Spanish-English bilingual children and the relationships among (a) early brain measures of phonetic discrimination in both languages, (b) degree of exposure to each language in the home, and (c) children’s later bilingual word production abilities. Speech discrimination was assessed with event-related brain potentials (ERPs). A bilingual questionnaire was used to quantify the amount of language exposure from all adult speakers in the household, and subsequent word production was evaluated in both languages. Our results suggest that bilingual infants’ brain responses to speech differ from the pattern shown by monolingual infants. Bilingual infants did not show neural discrimination of either the Spanish or English contrast at 6–9 months. By 10–12 months of age, neural discrimination was observed for both contrasts. Bilingual infants showed continuous improvement in neural discrimination of the phonetic units from both languages with increasing age. Group differences in bilingual infants’ speech discrimination abilities are related to the amount of exposure to each of their native languages in the home. Finally, we show that infants’ later word production measures are significantly related to both their early neural discrimination skills and the amount exposure to the two languages early in development. & 2011 Elsevier Ltd. All rights reserved.
Forensic analysis of Telegram Messenger on Android smartphones

In this paper we present a methodology for the forensic analysis of the artifacts generated on Android smartphones by Telegram Messenger, the official client for the Telegram instant messaging platform, which provides various forms of secure individual and group communication, by means of which both textual and non-textual messages can be exchanged among users, as well as voice calls. Our methodology is based on the design of a set of experiments suitable to elicit the generation of artifacts and their retention on the device storage, and on the use of virtualized smartphones to ensure the generality of the results and the full repeatability of the experiments, so that our findings can be reproduced and validated by a third-party. In this paper we show that, by using the proposed methodology, we are able (a) to identify all the artifacts generated by Telegram Messenger, (b) to decode and interpret each one of them, and (c) to correlate them in order to infer various types of information that cannot be obtained by considering each one of them in isolation. As a result, in this paper we show how to reconstruct the list of contacts, the chronology and contents of the messages that have been exchanged by users, as well as the contents of files that have been sent or received. Furthermore, we show how to determine significant properties of the various chats, ∗Corresponding author. Address: viale T. Michel 11, 15121 Alessandria (Italy). Phone: +39 0131 360188. Email addresses: cosimo.anglano@uniupo.it (Cosimo Anglano), massimo.canonico@uniupo.it (Massimo Canonico), marco.guazzone@uniupo.it (Marco Guazzone) Preprint submitted to Digital Investigation December 21, 2017 groups, and channels in which the user has been involved (e.g., the identifier of the creator, the date of creation, the date of joining, etc.). Finally, we show how to reconstruct the log of the voice calls made or received by the user. Although in this paper we focus on Telegram Messenger, our methodology can be applied to the forensic analysis of any application running on the Android platform.
Psychological, physical, and academic correlates of cyberbullying and traditional bullying.

PURPOSE
To examine the relationship between children's and adolescents' experiences with cyberbullying and traditional bullying and psychological health, physical health, and academic performance.


METHODS
Nine hundred thirty-one students in grades 6 through 12 completed an anonymous survey examining their experiences with cyberbullying and traditional bullying. Also included were measures of anxiety, depression, self-esteem, physical well-being, school attendance, and academic performance.


RESULTS
Participants were categorized as belonging to one of four groups: cyber victims, cyberbullies, cyber bully/victims, and those not involved in cyberbullying. A similar categorization was done with traditional bullying. Those in the bully/victim groups (and particularly the cyber bully/victim group) had the most negative scores on most measures of psychological health, physical, health, and academic performance.


CONCLUSIONS
There appears to be a substantial, although not perfect, overlap between involvement in traditional bullying and cyberbullying. Additionally, the physical, psychological, and academic correlates of the two types of bullying resembled one another.
Anti-inflammatory and anticoagulant effects of pravastatin in patients with type 2 diabetes.

OBJECTIVE
Type 2 diabetes is associated with increased plasma concentrations of coagulation and inflammation markers. Different studies have shown that treatment with hydroxymethylglutaryl-CoA reductase inhibitors (statins) is associated with antithrombotic and anti-inflammatory effects in addition to a cholesterol-lowering effect. Our objective was to evaluate the effect of pravastatin (40 mg/day) on coagulation and inflammation markers in type 2 diabetic patients.


RESEARCH DESIGN AND METHODS
This was an open, randomized, crossover study designed with an 8-week intervention period. The study group was comprised of 50 patients with type 2 diabetes (median HbA(1c) 7.1%) and serum total cholesterol of 5-10 mmol/l. We evaluated plasma levels of fibrinogen, F1 + 2, D-dimer, soluble tissue factor (sTF), von Willebrand Factor antigen (vWFag), and C-reactive protein (CRP) in blood samples drawn after fasting on day 1 and after 8 and 16 weeks.


RESULTS
Significant reductions of total cholesterol (-22%; P < 0.001), LDL cholesterol (-32%; P < 0.001), and triglycerides (-10%; P < 0.05) were achieved after 8 weeks of treatment with pravastatin. In addition, significant reductions of plasma levels of F1 + 2 (-4.4%; P < 0.05), vWFag (-5.3%; P < 0.05), and sTF (-3.4%; P < 0.05) were observed after treatment with pravastatin. Furthermore, plasma levels of CRP were also significantly reduced (-13%; P < 0.05). Levels of fibrinogen and D-dimer did not decrease after treatment with pravastatin.


CONCLUSIONS
The results indicated that pravastatin reduces levels of coagulation and inflammation markers in type 2 diabetic patients. These antithrombotic and anti-inflammatory effects of treatment with statins could play a role in reducing cardiovascular complications in type 2 diabetic patients.
Job characteristics and quality of working life in the IT workforce: the role of gender

Women are largely underrepresented in the Information Technology (IT) workforce. Our research examines the factors related to the work environment that may contribute to the high turnover of women in the IT workforce. There is substantial research providing support for the relationship between job and organizational factors, on one hand, and quality of working life (QWL) (e.g., low job satisfaction and high job strain), on the other hand. In this paper, we conduct secondary data analysis of questionnaire survey collected from a sample of 1,278 employees of a single organization. We examine the impact of gender and job type (i.e. IT job versus non-IT job) on various indicators of quality of working life, as well as on the relationship between job and organizational factors (i.e. feedback, autonomy, skill variety, task significance, task identity and work pressure) and QWL. Results show that IT workers reported higher job satisfaction and lower job strain than non-IT workers. Gender had no impact on QWL. Feedback and autonomy were consistently related to job satisfaction, and work pressure was consistently related to job strain, irrespective of gender and type of job. On the other hand, women IT workers' job satisfaction was affected by work pressure, and women IT workers' job strain was affected by task significance. Women IT workers' job strain was not affected by autonomy, whereas job strain experienced by non-IT workers was affected by autonomy.
Serum Autotaxin/ENPP2 Correlates with Insulin Resistance in Older Humans with Obesity

OBJECTIVE
Autotaxin (ATX) is an adipocyte-derived lysophospholipase D that generates the lipid signaling molecule lysophosphatidic acid (LPA). The ATX/LPA pathway in adipose tissue has recently been implicated in obesity and insulin resistance in animal models, but the role of circulating ATX in humans remains unclear. The aim of the present study was to determine the relationship between serum ATX and insulin resistance.


METHODS
Older (60-75 years), nondiabetic human participants with overweight or obesity (BMI 25-37 kg m(-2) ) were characterized for metabolic phenotype including measures of energy, glucose, and lipid homeostasis. The relationship between serum ATX and metabolic parameters was then determined using correlative and predictive statistics.


RESULTS
Serum ATX was higher in females than in males. After controlling for sex, serum ATX correlated with multiple measures of adiposity and glucose homeostasis/insulin action. Serum ATX and BMI also independently predicted glucose infusion rate during a hyperinsulinemic euglycemic clamp and homeostatic model assessment of insulin resistance after controlling for sex and medication use.


CONCLUSIONS
Serum ATX correlates with and predicts measures of glucose homeostasis and insulin sensitivity in older humans, suggesting that it may be a potential pathogenic factor and/or diagnostic/therapeutic target for insulin resistance in this population.
Estimating Bargaining Games in Distribution Channels

The issue of power in distribution channels remains a topic of interest among both practitioners and researchers of marketing. This interest has, no doubt, been fueled by the growing power of retailers and the emergence of retail powerhouses such as Walmart. Power, in a distribution channels context, is often dened as the ability to appropriate a larger share of the total channel surplus. In a simple manufacturer-retailer setting wholesale prices determine the prot share a given channel member appropriates and consequently, power is directly related to the process of wholesale price setting. In most previous studies of channel interactions, it is assumed that the wholesale price is set by the manufacturer unilaterally, i.e. the manufacturer makes a take-it or leave-it o¤er to the retailer. A few notable exceptions are the theoretical works of Villas Boas and Iyer (2002) and Sha¤er and OBrien (2004) who examine channel relations and price setting in a formal bilateral bargaining framework. There is also enough anecdotal evidence to suggest that wholesale prices are indeed set via a bargaining process rather than by unilateral mandates issued by manufacturers. This paper relies on Nash bargaining theory to propose and implement an econometric framework to investigate channel structure and power. In a supermarket/retail store setting, we assume that the wholesale prices are negotiated between competing manufacturers and a common retailer. We model the negotiation process using a modied Nash bargaining framework with asymmetric bargaining powers. The wholesale prices that emerge as an outcome of the bargaining process are a function of anticipated prots and relative bargaining powers. The theoretical solution suggests that gains from trade be split in proportion to the bargaining powers of the trading parties. We contrast our proposed model with some of the standard models used in the Empirical Industrial Organization literature (e.g. Manufacturer Stackelberg) by calibrating each model to data from two di¤erent product categories. We nd that in terms of t, our proposed model performs better than extant models of channel interactions and hence provides empirical evidence to support bargaining as the more plausible pricing mechanism in distribution channels. While our results continue to support notions of power obtained in previous studies (e.g. a manufacturer with a high market share has relatively more power) they also shed light on nuances that were hitherto unexplored. Particular among there are the factors that inuence bargaining power such as cost advantages and brand equity.