LLukas22/scidocs huggingface dataset:
Sorting of Permutations by Cost-Constrained Transpositions

The problem of finding a minimum decomposition of a permutation in terms of transpositions with predetermined non-uniform and non-negative costs is addressed. Alternatively, computing the transposition distance between two permutations, where transpositions are endowed with arbitrary non-negative costs, is studied. For such cost functions, polynomial-time, constant-approximation decomposition algorithms are described. For metric-path costs, exact polynomial-time decomposition algorithms are presented. The algorithms in this paper represent a combination of Viterbi-type algorithms and graph-search techniques for minimizing the cost of individual transpositions, and dynamic programing algorithms for finding minimum cost decompositions of cycles. The presented algorithms have a myriad of applications in information theory, bioinformatics, and algebra.
Maxillary molar and premolar indices in North Indians: A Dimorphic Study

Tooth morphometry is known to be influenced by cultural, environmental and racial factors. Tooth size standards can be used in age and sex determination. One hundred models (50 males & 50 females) of normal occlusion were evaluated and significant correlations (p<0.001) were found to exist between the combined maxillary incisor widths and the maxillary intermolar and interpremolar arch widths. The study establishes the morphometric criterion for premolar and molar indices and quantifies the existence of a statistically significant sexual dimorphism in arch widths (p<0.02). INTRODUCTION Teeth are an excellent material in living and non-living populations for anthropological, genetic, odontologic and forensic investigations 1 .Their morphometry is known to be influenced by cultural, environmental and racial factors. The variations in tooth form are a common occurrence & these can be studied by measurements. Out of the two proportionswidth and length, the former is considered to be more important 2 . Tooth size standards can be used in age and sex determination 3 . Whenever it is possible to predict the sex, identification is simplified because then only missing persons of one sex need to be considered. In this sense identification of sex takes precedence over age 4 . Various features like tooth morphology and crown size are characteristic for males and females 5 .The present study on the maxillary arch takes into account the premolar arch width, molar arch width and the combined width of the maxillary central incisors in both the sexes. Pont's established constant ratio's between tooth sizes and arch widths in French population which came to be known as premolar and molar indices 6 .In the ideal dental arch he concluded that the ratio of combined incisor width to transverse arch width was .80 in the premolar area and .64 in the molar area. There has been a recent resurgence of interest in the clinical use of premolar and molar indices for establishing dental arch development objectives 7 . The present study was conducted to ascertain whether or not Pont's Index can be used reliably on north Indians and to establish the norms for the same. MATERIAL AND METHODS SELECTION CRITERIA One hundred subjects, fifty males and fifty females in the age group of 17-21 years were selected for the study as attrition is considered to be minimal for this age group. The study was conducted on the students of Sudha Rustagi College of Dental Sciences & Research, Faridabad, Haryana. INCLUSION CRITERIA Healthy state of gingival and peridontium.
A Tender Pulsatile Mass in a Patient with Splenomegaly.

A 30-years-old lady having lump in left upper abdomen for 10 years and now she presented with severe pain in same area with radiation to left shoulder for 1 week. Clinical examination revealed pallor, icterus, massive splenomegaly and a tender pulsatile lump of size 6 6 cm adjacent to spleen with a bruit. On investigations she was anemic with a hemoglobin of 8.7 g/dl (normal, 14–18 g/dl), total leukocyte count of 3800/ mm (normal, 4000–10000/mm), platelet count of 76000/ mm (normal 1.5–4.5 lakhs/mm), total bilirubin of 1.1mg/
Towards spoken clinical-question answering: evaluating and adapting automatic speech-recognition systems for spoken clinical questions

OBJECTIVE
To evaluate existing automatic speech-recognition (ASR) systems to measure their performance in interpreting spoken clinical questions and to adapt one ASR system to improve its performance on this task.


DESIGN AND MEASUREMENTS
The authors evaluated two well-known ASR systems on spoken clinical questions: Nuance Dragon (both generic and medical versions: Nuance Gen and Nuance Med) and the SRI Decipher (the generic version SRI Gen). The authors also explored language model adaptation using more than 4000 clinical questions to improve the SRI system's performance, and profile training to improve the performance of the Nuance Med system. The authors reported the results with the NIST standard word error rate (WER) and further analyzed error patterns at the semantic level.


RESULTS
Nuance Gen and Med systems resulted in a WER of 68.1% and 67.4% respectively. The SRI Gen system performed better, attaining a WER of 41.5%. After domain adaptation with a language model, the performance of the SRI system improved 36% to a final WER of 26.7%.


CONCLUSION
Without modification, two well-known ASR systems do not perform well in interpreting spoken clinical questions. With a simple domain adaptation, one of the ASR systems improved significantly on the clinical question task, indicating the importance of developing domain/genre-specific ASR systems.
Reactivation of herpes simplex virus type 2 after initiation of antiretroviral therapy.

BACKGROUND
The association between initiation of antiretroviral therapy (ART) for human immunodeficiency virus (HIV) infection and possible herpes simplex virus type 2 (HSV-2) shedding and genital ulcer disease (GUD) has not been evaluated.


METHODS
GUD and vaginal HSV-2 shedding were evaluated among women coinfected with HIV and HSV-2 (n = 440 for GUD and n = 96 for HSV-2 shedding) who began ART while enrolled in a placebo-controlled trial of HSV-2 suppression with acyclovir in Rakai, Uganda. Monthly vaginal swabs were tested for HSV-2 shedding, using a real-time quantitative polymerase chain reaction assay. Prevalence risk ratios (PRRs) of GUD were estimated using log binomial regression. Random effects logistic regression was used to estimate odds ratios (ORs) of HSV-2 shedding.


RESULTS
Compared with pre-ART values, GUD prevalence increased significantly within the first 3 months after ART initiation (adjusted PRR, 1.94; 95% confidence interval [CI], 1.04-3.62) and returned to baseline after 6 months of ART (adjusted PRR, 0.80; 95% CI, .35-1.80). Detection of HSV-2 shedding was highest in the first 3 months after ART initiation (adjusted OR, 2.58; 95% CI, 1.48-4.49). HSV-2 shedding was significantly less common among women receiving acyclovir (adjusted OR, 0.13; 95% CI, .04-.41).


CONCLUSIONS
The prevalence of HSV-2 shedding and GUD increased significantly after ART initiation, possibly because of immune reconstitution inflammatory syndrome. Acyclovir significantly reduced both GUD and HSV-2 shedding and should be considered to mitigate these effects following ART initiation.
Part-of-Speech Tagger for Marathi Language using Limited Training Corpora

Part-of-speech tagging in Marathi language is a very complex task as Marathi is highly inflectional in nature & free word order language. In this paper we have demonstrated a rule-based Part-of-Speech tagger for Marathi Language. The hand–constructed rules that are learned from corpus and some manual addition after studying the grammar of Marathi language are added and that are used for developing the tagger. Disambiguation is done by analyzing
Looking for Logic in Vision

This paper presents how the axioms of equivalence can be induced from visual observation without assuming background knowledge. The present research was conducted upon a system that combines computer vision with inductive logic programming that was first designed to learn protocol behaviour from observation.
Copyright and the net: is legislation the answer? (panel session)

These and related issues will confront the 105th Congress in the coming year. They will also be examined by this panel, which will discuss controversies surrounding the extension of copyright law to deal with cyberspace. Examples include: How does proposed legislation reflect, the net? How much influence have lobbyists for the entertainment industry had in writing legislation? What should be the role of professional societies in analyzing policy initiatives?
Two-Stage Offshoring: An Investigation of the Irish Bridge

This paper investigates two-stage offshoring as experienced by the Irish sites of two large global companies, headquartered in the United States, with significant software development operations. As part of these companies, the Irish sites act as a bridge in their offshoring arrangements: While the U.S. sites offshore work to Ireland, the Irish sites offshore work further to India and, hence, have experience of being both customer and vendor in two-stage offshore sourcing relationships. Using a framework derived from relational exchange theory (RET), we conducted multiple case study research to investigate and develop an initial theoretical model of the implementation of this two-stage offshoring bridge model. Our study shows that while both companies act as bridges in two-stage offshoring arrangements, their approaches differ in relation to (1) team integration, (2) organizational level implementation, and (3) site hierarchy. Although, there are opportunities afforded by the bridge model at present, the extent to which these opportunities will be viable into the future is open to question. As revealed in our study, temporal location seems to favor a bridge location such as Ireland, certainly with United States–Asian partners. However, location alone will not be enough to maintain position in future two-stage offshoring arrangements. Furthermore, our research supports the view that offshoring tends to progress through a staged sequence of progressively lower cost destinations. Such a development suggests that two-stage offshoring, as described in this paper, will eventually become what we would term multistage offshoring.
Improving Care of Patients At-Risk for Osteoporosis: A Randomized Controlled Trial

Despite accurate diagnostic tests and effective therapies, the management of osteoporosis has been observed to be suboptimal in many settings. We tested the effectiveness of an intervention to improve care in patients at-risk of osteoporosis. Randomized controlled trial. Primary care physicians and their patients at-risk of osteoporosis, including women 65 years and over, men and women 45 and over with a prior fracture, and men and women 45 and over who recently used ≥90 days of oral glucocorticoids. A multifaceted program of education and reminders delivered to primary care physicians as well as mailings and automated telephone calls to patients. Outcome: Either undergoing a bone mineral density (BMD) testing or filling a prescription for a bone-active medication during the 10 months of follow-up. After the intervention, 144 (14%) patients in the intervention group and 97 (10%) patients in the control group received either a BMD test or filled a prescription for an osteoporosis medication. This represents a 4% absolute increase and a 45% relative increase (95% confidence interval 9–93%, p = 0.01) in osteoporosis management between the intervention and control groups. No differences between groups were observed in the incidence of fracture. An intervention targeting primary care physicians and their at-risk patients increased the frequency of BMD testing and/or filling prescriptions for osteoporosis medications. However, the absolute percentage of at-risk patients receiving osteoporosis management remained low.
Left ventricular systolic dysfunction associated with pulmonary hypertension riociguat trial (LEPHT): rationale and design.

AIMS
Pulmonary hypertension (PH) due to systolic left ventricular dysfunction (PH-sLVD) frequently complicates heart failure (HF), and greatly worsens the prognosis of patients with sLVD, but as yet has no approved treatment. The LEPHT study aims to characterize the haemodynamic profile, safety, tolerability, and pharmacokinetic profile of riociguat (BAY 63-2521), an oral stimulator of soluble guanylate cyclase, in patients with PH-sLVD.


METHODS AND RESULTS
This 16-week, phase IIb, randomized, placebo-controlled, double-blind study enrols patients with PH-sLVD, defined as left ventricular ejection fraction (LVEF) ≤40% and mean pulmonary arterial pressure (PAP(mean)) ≥25 mmHg at rest. Patients using optimized HF medication will receive placebo or riociguat 0.5 mg, 1 mg, or up to 2 mg three times daily. The dose will be titrated for 8 weeks, based on systolic blood pressure and well-being, followed by 8 weeks of treatment at a stable dose. The primary efficacy variable is PAP(mean), while secondary efficacy endpoints include LVEF, exercise capacity, quality of life, and other haemodynamic and echocardiographic measurements. Safety and pharmacokinetics will also be assessed. After the 16-week study, patients will have the opportunity to be treated with riociguat in a long-term extension phase.


CONCLUSION
The LEPHT study will provide valuable information on the haemodynamic, echocardiographic, and preliminary clinical effects of riociguat in patients with PH-sLVD. Trial registration NCT01065454.
Genetic association of the CCR5 region with lipid levels in at-risk cardiovascular patients.

BACKGROUND
There is mounting evidence to suggest that chemokine receptor 5 (CCR5) plays an important role in the development and progression of atherosclerosis. A naturally occurring variant of the CCR5 gene CCR532, exists at allele frequencies of typically 10% in European populations and results in a nonfunctional CCR5 receptor.


METHODS AND RESULTS
The CCR5Delta32 deletion and 26 other variants within the chemokine receptor 2-CCR5-chemokine receptor-like protein 2 (CCRL2) gene cluster spanning 59 kilobases of chromosome 3 were genotyped in 5748 subjects from the Treating to New Targets atorvastatin trial to determine whether genetic associations could be identified with circulating lipid values and cardiovascular disease. Our results demonstrate an association between the CCR5Delta32 deletion and increased plasma high-density lipoprotein cholesterol and decreased plasma triglycerides, both of which are beneficial from a cardiovascular perspective. Three single-nucleotide polymorphisms (rs1154428, rs6808835, and rs6791599) in CCRL2 in linkage disequilibrium (r(2)> or =0.65) with CCR5Delta32 and located up to 45 kilobases distal to it were associated with high-density lipoprotein cholesterol. The high-density lipoprotein cholesterol and triglycerides findings were replicated in an additional set of >6000 individuals from the Incremental Decrease in Endpoints through Aggressive Lipid Lowering atorvastatin trial.


CONCLUSIONS
Our study provides evidence that a locus within the region of the genome encompassing the CCR5-CCRL2 region is associated with lipid levels and suggests that chemokine activity influences lipid levels in populations with preexisting cardiovascular disease. CLINICAL TRIAL REGISTRATION- clinicaltrials.gov. Identifier: TNT, NCT00327691; IDEAL, NCT00159835.
Reducing medical claims cost to Ghana’s National Health Insurance scheme: a cross-sectional comparative assessment of the paper- and electronic-based claims reviews

BACKGROUND
A robust medical claims review system is crucial for addressing fraud and abuse and ensuring financial viability of health insurance organisations. This paper assesses claims adjustment rate of the paper- and electronic-based claims reviews of the National Health Insurance Scheme (NHIS) in Ghana.


METHODS
The study was a cross-sectional comparative assessment of paper- and electronic-based claims reviews of the NHIS. Medical claims of subscribers for the year, 2014 were requested from the claims directorate and analysed. Proportions of claims adjusted by the paper- and electronic-based claims reviews were determined for each type of healthcare facility. Bivariate analyses were also conducted to test for differences in claims adjustments between healthcare facility types, and between the two claims reviews.


RESULTS
The electronic-based review made overall adjustment of 17.0% from GHS10.09 million (USD2.64 m) claims cost whilst the paper-based review adjusted 4.9% from a total of GHS57.50 million (USD15.09 m) claims cost received, and the difference was significant (p < 0.001). However, there were no significant differences in claims cost adjustment rate between healthcare facility types by the electronic-based (p = 0.0656) and by the paper-based reviews (p = 0.6484).


CONCLUSIONS
The electronic-based review adjusted significantly higher claims cost than the paper-based claims review. Scaling up the electronic-based review to cover claims from all accredited care providers could reduce spurious claims cost to the scheme and ensure long term financial sustainability.
Value of debriefing during simulated crisis management: oral versus video-assisted oral feedback.

BACKGROUND
The debriefing process during simulation-based education has been poorly studied despite its educational importance. Videotape feedback is an adjunct that may enhance the impact of the debriefing and in turn maximize learning. The purpose of this study was to investigate the value of the debriefing process during simulation and to compare the educational efficacy of two types of feedback, oral feedback and videotape-assisted oral feedback, against control (no debriefing).


METHODS
Forty-two anesthesia residents were enrolled in the study. After completing a pretest scenario, participants were randomly assigned to receive no debriefing, oral feedback, or videotape-assisted oral feedback. The debriefing focused on nontechnical skills performance guided by crisis resource management principles. Participants were then required to manage a posttest scenario. The videotapes of all performances were later reviewed by two blinded independent assessors who rated participants' nontechnical skills using a validated scoring system.


RESULTS
Participants' nontechnical skills did not improve in the control group, whereas the provision of oral feedback, either assisted or not assisted with videotape review, resulted in significant improvement (P < 0.005). There was no difference in improvement between oral and video-assisted oral feedback groups.


CONCLUSIONS
Exposure to a simulated crisis without constructive debriefing by instructors offers little benefit to trainees. The addition of video review did not offer any advantage over oral feedback alone. Valuable simulation training can therefore be achieved even when video technology is not available.
Orbit Determination and Differential-drag Control of Planet Labs Cubesat Constellations

We present methodology and mission results from orbit determination of Planet Labs nanosatellites and differential-drag control of their relative motion. Orbit determination (OD) is required on Planet Labs satellites to accurately predict the positioning of satellites during downlink passes and we present a scalable OD solution for large fleets of small satellites utilizing two-way ranging. In the second part of this paper, we present mission results from relative motion differential-drag control of a constellation of satellites deployed in the same orbit.
Self-Taught Low-Rank Coding for Visual Learning

The lack of labeled data presents a common challenge in many computer vision and machine learning tasks. Semisupervised learning and transfer learning methods have been developed to tackle this challenge by utilizing auxiliary samples from the same domain or from a different domain, respectively. Self-taught learning, which is a special type of transfer learning, has fewer restrictions on the choice of auxiliary data. It has shown promising performance in visual learning. However, existing self-taught learning methods usually ignore the structure information in data. In this paper, we focus on building a self-taught coding framework, which can effectively utilize the rich low-level pattern information abstracted from the auxiliary domain, in order to characterize the high-level structural information in the target domain. By leveraging a high quality dictionary learned across auxiliary and target domains, the proposed approach learns expressive codings for the samples in the target domain. Since many types of visual data have been proven to contain subspace structures, a low-rank constraint is introduced into the coding objective to better characterize the structure of the given target set. The proposed representation learning framework is called self-taught low-rank (S-Low) coding, which can be formulated as a nonconvex rank-minimization and dictionary learning problem. We devise an efficient majorization–minimization augmented Lagrange multiplier algorithm to solve it. Based on the proposed S-Low coding mechanism, both unsupervised and supervised visual learning algorithms are derived. Extensive experiments on five benchmark data sets demonstrate the effectiveness of our approach.
Data stream mining in ubiquitous environments: state-of-the-art and current directions

In this article, we review the state-of-the-art techniques in mining data streams for mobile and ubiquitous environments. We start the review with a concise background of data stream processing, presenting the building blocks for mining data streams. In a wide range of applications, data streams are required to be processed on small ubiquitous devices like smartphones and sensor devices. Mobile and ubiquitous data mining target these applications with tailored techniques and approaches addressing scarcity of resources and mobility issues. Two categories can be identified for mobile and ubiquitous mining of streaming data: single-node and distributed. This survey will cover both categories. Mining mobile and ubiquitous data require algorithms with the ability to monitor and adapt the working conditions to the available computational resources. We identify the key characteristics of these algorithms and present illustrative applications. Distributed data stream mining in the mobile environment is then discussed, presenting the Pocket Data Mining framework. Mobility of users stimulates the adoption of context-awareness in this area of research. Context-awareness and collaboration are discussed in the Collaborative Data Stream Mining, where agents share knowledge to learn adaptive accurate models. © 2014 John Wiley & Sons, Ltd.