LLukas22/scidocs huggingface dataset:
Affective priming in schizophrenia with and without affective negative symptoms

In the present study automatic perceptual sensitivity to facial affect information was examined in chronic schizophrenic patients. An affective priming task including subliminal and supraliminal presentations of sad and happy facial affect was administered to schizophrenia patients with a flat affect expression (n = 30), schizophrenia patients suffering from anhedonia (n = 30), schizophrenia patients not suffering from anhedonia or flat affect (n = 28), and a group of healthy controls (n = 30). Subjects had to judge valence of neutral Chinese ideographs. Anhedonic and flat affect patients but not patients without affect symptoms were found to be sensitive to negative facial affect on an automatic processing level. None of the schizophrenic patient groups but healthy controls showed a subliminal valence-congruent priming effect based on positive facial affect. Anhedonia as assessed by standardised psychiatric rating was related to a subliminal sensitivity to negative facial expression and a valence-inverted perception of positive facial expression. This pattern of results is largely consistent with predictions derived from Meehl’s model of anhedonia. The aversive automatic perception of positive facial expression primarily found in anhedonic patients but also in schizophrenic control patients could lie in structural disturbances concerning the regulation of intimacy and distance.
Prevalence of molar-incisor hypomineralization (MIH) in children seeking dental care at the Schools of Dentistry of the University of Buenos Aires (Argentina) and University of la Republica (Uruguay).

UNLABELLED
The objectives of this study are to compare the prevalence of MIH in children seeking dental care spontaneously at the Department of Comprehensive Children's Dentistry of the University of Buenos Aires (UBA) and Department of Pediatric Dentistry of the University of La República (UdelaR) and to analyze the distribution according to year of birth, sex, age, number of affected teeth and maximum degree of severity in molars and incisors. During 2010, nine pediatric dentists from both schools (Kappa = 0.94) assessed all children born between 1993 and 2003 whose 4 first molars and 8 permanent incisors had erupted. Specially designed charts were used to record sex, year of birth, institution, presence of MIH, number of affected incisors and molars and maximum degree of severity for each tooth. Two groups were formed: UBA: A (n = 512) and UdelaR: B (n = 463).


RESULTS
975 children (11.6 +/- 2.67 years) were evaluated. The prevalence of MIH in the total sample was 6.56%, without significant differences between A and B (p = 0.76). There was no significant difference between groups regarding age (p = 0. 95) or sex (p = 0.30). A significant increase was found in both institutions according to year of birth during the study period. (A: p = 0.0017) B: p = 0. 0058).


CONCLUSIONS
The results of this study show a similar prevalence of MIH among patients seeking dental care at the Schools of Dentistry of the University of Buenos Aires (Argentina) and University of la República (Uruguay). No significant difference was found comparing the distribution by sex, affected teeth or severity of each tooth. A highly significant positive correlation was found regarding the year of birth. The relevance of MIH as an emerging pathology requires studies on larger samples covering the entire countries.
Text extraction in complex color documents

Text extraction in mixed-type documents is a pre-processing and necessary stage for many document applications. In mixed-type color documents, text, drawings and graphics appear with millions of di0erent colors. In many cases, text regions are overlaid onto drawings or graphics. In this paper, a new method to automatically detect and extract text in mixed-type color documents is presented. The proposed method is based on a combination of an adaptive color reduction (ACR) technique and a page layout analysis (PLA) approach. The ACR technique is used to obtain the optimal number of colors and to convert the document into the principal of them. Then, using the principal colors, the document image is split into the separable color plains. Thus, binary images are obtained, each one corresponding to a principal color. The PLA technique is applied independently to each of the color plains and identi4es the text regions. A merging procedure is applied in the 4nal stage to merge the text regions derived from the color plains and to produce the 4nal document. Several experimental and comparative results, exhibiting the performance of the proposed technique, are also presented. ? 2002 Pattern Recognition Society. Published by Elsevier Science Ltd. All rights reserved.
Phased multipolar radiofrequency pulmonary vein isolation is as effective and safe as conventional irrigated point-to-point ablation. A prospective randomised 1-year implantable cardiac monitoring device follow-up trial

Pulmonary vein isolation (PVI) is conventionally performed using 3D electroanatomical mapping to guide point-to-point ablation. The Pulmonary Vein Ablation Catheter (PVAC)® is a phased multipolar ablation (PMRA) catheter designed for rapid PVI using radiological anatomical information. Comparison of these methods of PVI using continuous beat-to-beat monitoring was undertaken. Fifty patients with drug-refractory, symptomatic paroxysmal atrial fibrillation (PAF) were recruited. Patients all had REVEAL® XT ILR or a DDDRP permanent pacemaker (PPM) inserted prior to PVI. PPM was programmed to monitoring mode (ODO). Patients were randomised 1:1 to undergo PVI with either point-to-point irrigated radiofrequency ablation (Conv) or PMRA technology. Follow-up was performed at 0, 3, 6, 9, and 12 months using Holter downloads to assess arrhythmia burden. Outcomes were examined following a 3-month blanking period. The AF burden pre-ablation, at 3-month and at 12-month post-ablations, was not significantly different (pre-ablation AF burdens (mean ± SE) Conv 16.6 ± 5.0 %, PVAC 17.0 ± 5.6 %, 3 months Conv 4.0 ± 1.6 %, PVAC 4.7 ± 1.5 %, 12 months Conv 4.3 ± 2.3 %, PVAC 3.8 ± 1.5 %). In both groups, there was a significant reduction in AF burden from pre-ablation (at 3 months p = 0.01, p = 0.04, at 12 months p = 0.04, p = 0.03 for Conv and PMRA groups, respectively). Overall success rate for zero AF recurrence at 12 months was 54 %. PMRA PVI is comparable to conventional technology for AF extinction at 1 year. The PMRA is as safe as conventional technology but enables the operator to perform the procedure faster. Device monitored success rates were lower than other studies not utilising such intensive monitoring confirming that sporadic ECG monitoring is not sufficient to detect all AF recurrence. NCT01095770. URL: https://clinicaltrials.gov/ct2/show/NCT01095770
Lesbian Life and Literature: A Survey of Recent German-Language Publications

The article discusses similarities and differences of Lesbian/Gay politics and culture in German-speaking countries and in the USA and surveys recent non-fiction German-language publications, documenting widespread cultural borrowing and a keen interest in historical research. A new genre, the "merged anthology," juxtaposes the pioneering work of non-German writers/activists in translation with original German contributions on related themes. Recent scholarly works provide a historical survey of Lesbian literature and document the existence of Lesbian subcultures in the GDR, in Switzerland in the 1930s and 1940s, and in Germany during the Third Reich. Analysis of the specifically German situation demonstrates the intrinsic connection between homophobia, racism, and institutionalized violence by the State. (JC)
A Black-box Approach for Response Quality Evaluation of Conversational Agent Systems

The evaluation of conversational agents or chatterbots question answering systems is a major research area that needs much attention. Before the rise of domain-oriented conversational agents based on natural language understanding and reasoning, evaluation is never a problem as information retrieval-based metrics are readily available for use. However, when chatterbots began to become more domain specific, evaluation becomes a real issue. This is especially true when understanding and reasoning is required to cater for a wider variety of questions and at the same time to achieve high quality responses. This paper discusses the inappropriateness of the existing measures for response quality evaluation and the call for new standard measures and related considerations are brought forward. As a short-term solution for evaluating response quality of conversational agents, and to demonstrate the challenges in evaluating systems of different nature, this research proposes a blackbox approach using observation, classification scheme and a scoring mechanism to assess and rank three example systems, AnswerBus, START and AINI. Keywords—Evaluation, conversational agents, Response Quality, chatterbots
Prognostic value of changes in N-terminal pro-brain natriuretic peptide in Val-HeFT (Valsartan Heart Failure Trial).

OBJECTIVES
This study sought to evaluate the association between changes over time of N-terminal pro-brain natriuretic peptide (NT-proBNP) expressed in different ways and outcome in patients with stable and chronic heart failure (HF).


BACKGROUND
Although previous studies examined the prognostic value of repeated determinations of BNP in HF, there are only limited data on the clinical utility of serial measurements of the inactive peptide NT-proBNP in a large population of ambulatory patients with chronic HF with sufficient follow-up time.


METHODS
The NT-proBNP was measured at randomization and after 4 months in 1,742 patients enrolled in the placebo arm of Val-HeFT (Valsartan Heart Failure Trial). Changes in NT-proBNP concentrations over 4 months were expressed as absolute change from baseline, percent relative changes, or categorical changes across a threshold value and related to subsequent mortality.


RESULTS
A single determination of NT-proBNP (area under the curve at 4 months: 0.702, 95% confidence interval [CI]: 0.669 to 0.735) showed a higher prognostic discrimination than continuous changes of concentrations, expressed either as absolute (0.592, 95% CI: 0.549 to 0.634) or relative changes (0.602, 95% CI: 0.566 to 0.639). A Cox proportional hazards model showed that stratification of patients into 4 categories according to NT-proBNP levels at 2 time points 4 months apart with respect to a threshold concentration provided prognostic information in patients with chronic HF beyond that of a single determination.


CONCLUSIONS
Serial determinations of NT-proBNP concentration and classification into few categories of changes according to threshold levels may be a superior strategy for risk stratification of patients with chronic and stable HF.
Fecal sludge management (FSM): analytical tools for assessing FSM in cities

This paper describes the results of a research study which aimed in part to develop a method for rapidly assessing fecal sludge management (FSM) in lowand middle-income cities. The method uses innovative tools to assess both the institutional context and the outcome in terms of the amount of fecal sludge safely managed. To assess FSM outcomes, a fecal sludge matrix and accompanying flow diagram was developed to illustrate the different pathways fecal sludge takes from containment in water closets, pits and tanks, through to treatment and reuse/disposal. This was supplemented by an FSM service delivery assessment (SDA) tool which measures the quality of the enabling environment, the level of service development and the level of commitment to service sustainability. The tools were developed through an iterative process of literature review, consultation and case studies. This paper considers previous work done on FSM, suggest reasons why it is often neglected in favour of sewerage, and highlights the importance of supporting the increasing focus on solving the FSM challenge. The tools are presented here as useful initial scoping instruments for use in advocacy around the need for a change in policy, funding or indeed a city’s overall approach to urban sanitation.
Light transmittance and micro-mechanical properties of bulk fill vs. conventional resin based composites

The aim of this study was to quantify the blue light that passes through different incremental thicknesses of bulk fill in comparison to conventional resin-based composites (RBCs) and to relate it to the induced mechanical properties. Seven bulk fill, five nanohybrid and two flowable RBCs were analysed. Specimens (n = 5) of three incremental thicknesses (2, 4 and 6 mm) were cured from the top for 20 s, while at the bottom, a spectrometer monitored in real time the transmitted irradiance. Micro-mechanical properties (Vickers hardness, HV, and indentation modulus, E) were measured at the top and bottom after 24 h of storage in distilled water at 37 °C. Electron microscope images were taken for assessing the filler distribution and size. Bulk fill RBCs (except SonicFill) were more translucent than conventional RBCs. Low-viscosity bulk fill materials showed the lowest mechanical properties. HV depends highly on the following parameters: material (ηp 2 = 0.952), incremental thickness (0.826), filler volume (0.747), filler weight (0.746) and transmitted irradiance (0.491). The bottom-to-top HV ratio (HVbt) was higher than 80 % in all materials in 2- and 4-mm increments (except for Premise), whereas in 6-mm increments, this is valid only in four bulk fill materials (Venus Bulk Fill, SDR, x-tra fil, Tetric EvoCeram Bulk Fill). The depth of cure is dependent on the RBC’s translucency. Low-viscosity bulk fill RBCs have lower mechanical properties than all other types of analysed materials. All bulk fill RBCs (except SonicFill) are more translucent for blue light than conventional RBCs. Although bulk fill RBCs are generally more translucent, the practitioner has to follow the manufacturer’s recommendations on curing technique and maximum incremental thickness.
An EOQ model with quantity discounts for both purchasing price and freight cost

This paper deals with an EOQ model in which both the unit purchasing price and the freight cost depend on the quantity of the lot size. The model adopts all units quantity discounts for the price and a general form of discounts for the freight cost. Investigation of the properties of an optimal solution allows us to develop an algorithm whose validity is illustrated through an example problem.
Anatomical variations between the sciatic nerve and the piriformis muscle: a contribution to surgical anatomy in piriformis syndrome

To detect the variable relationship between sciatic nerve and piriformis muscle and make surgeons aware of certain anatomical features of each variation that may be useful for the surgical treatment of the piriformis syndrome. The gluteal region of 147 Caucasian cadavers (294 limbs) was dissected. The anatomical relationship between the sciatic nerve and the piriformis muscle was recorded and classified according to the Beaton and Anson classification. The literature was reviewed to summarize the incidence of each variation. The sciatic nerve and piriformis muscle relationship followed the typical anatomical pattern in 275 limbs (93.6 %). In 12 limbs (4.1 %) the common peroneal nerve passed through and the tibial nerve below a double piriformis. In one limb (0.3 %) the common peroneal nerve coursed superior and the tibial nerve below the piriformis. In one limb (0.3 %) both nerves penetrated the piriformis. In one limb (0.3 %) both nerves passed above the piriformis. Four limbs (1.4 %) presented non-classified anatomical variations. When a double piriformis muscle was present, two different arrangements of the two heads were observed. Anatomical variations of the sciatic nerve around the piriformis muscle were present in 6.4 % of the limbs examined. When dissection of the entire piriformis is necessary for adequate sciatic nerve decompression, the surgeon should explore for the possible existence of a second tendon, which may be found either inferior or deep to the first one. Some rare, unclassified variations of the sciatic nerve should be expected during surgical intervention of the region.
Production and innovation when techniques are tacit: The case of education

Abstract The central theme of this paper is that the conventional economic theory of production does not hold, even approximately, in a field like education. After examining the result of input-output studies in education and the effect of government attempts to enhance education effectiveness, we provide a sketch of a new production theory for sectors where techniques are poorly articulated and idiosyncratic.
Supervised conventional interferon α2a in combination with ribavirin therapy is the preferred alternative for treatment of chronic hepatitis C

OBJECTIVE
To document the significant sustained virological response with supervised conventional interferon α and ribavirin therapy in hepatitis C virus (HCV)-infected patients, this study was planned.


MATERIALS AND METHODS
Sixty chronic hepatitis C naive patients were included in this study. Complete blood counts, prothrombin time, ALT, AST, and qualitative HCV RNA were done. Conventional interferon (INF) α2a, 3MIU, S.C and ribavirin 1000 mg PO was given as supervised therapy for 24 weeks in genotype 3 and 48 weeks in genotype 1 and 4 HCV patients. Qualitative HCV RNA was repeated at 12 weeks, 24 weeks for HCV infections with genotype 1, 2, 3 and 4, at 48 weeks for genotype 1 and 4, and thereafter 6 months after completion of treatment. End virological and sustained virological responses were observed.


RESULTS
Out of 60 patients, 55 completed the study. Five patients were lost to follow-up. Overall SVR was seen in 47 patients (85.4%) and 4 patients had relapses.


CONCLUSION
Significant sustained virological response rates were seen in patients with supervised conventional INF α2a and ribavirin therapy.
Software-defined networking (SDN): a survey

With the advent of cloud computing, many new networking concepts have been introduced to simplify network management and bring innovation through network programmability. The emergence of the software-defined networking (SDN) paradigm is one of these adopted concepts in the cloud model so as to eliminate the network infrastructure maintenance processes and guarantee easy management. In this fashion, SDN offers real-time performance and responds to high availability requirements. However, this new emerging paradigm has been facing many technological hurdles; some of them are inherent, while others are inherited from existing adopted technologies. In this paper, our purpose is to shed light on SDN related issues and give insight into the challenges facing the future of this revolutionary network model, from both protocol and architecture perspectives. Additionally, we aim to present different existing solutions and mitigation techniques that address SDN scalability, elasticity, dependability, reliability, high availability, resiliency, security, and performance concerns. Copyright © 2017 John Wiley & Sons, Ltd.
Clinical trial: once-daily mesalamine granules for maintenance of remission of ulcerative colitis - a 6-month placebo-controlled trial.

BACKGROUND
Ulcerative colitis (UC) is a chronic relapsing and remitting idiopathic inflammatory bowel disorder.


AIM
To evaluate once-daily mesalamine (mesalazine) granules (MG) for maintenance of remission of UC.


METHODS
Randomized, double-blind, placebo-controlled trial of patients (n=209 MG, n=96 placebo) with UC in remission [revised Sutherland Disease Activity Index (SDAI) rectal bleeding=0, mucosal appearance <2] who took MG 1.5 g or placebo once-daily for up to 6 months. Primary efficacy endpoint: the percentage of patients who remained relapse-free at month 6/end of treatment. Relapse was defined as SDAI rectal bleeding score ≥1 and a mucosal appearance score ≥2, a UC flare, or initiation of medication to treat a UC flare.


RESULTS
The percentage of relapse-free patients at month 6/end of treatment was higher with MG than placebo (78.9% vs. 58.3%, P < 0.001) in the intent-to-treat analysis. Significant differences (P ≤ 0.025) favouring MG were observed for most secondary endpoints including improvement in rectal bleeding, physician's disease activity rating, stool frequency, the SDAI at month 6/end of treatment, patients classified as a treatment success and relapse-free duration. The incidence of adverse events was similar between groups.


CONCLUSIONS
Once-daily mesalamine (mesalazine) was effective in maintaining remission of UC for 6 months.
Comprehensive proteome analysis of Actinoplanes sp. SE50/110 highlighting the location of proteins encoded by the acarbose and the pyochelin biosynthesis gene cluster.

UNLABELLED
Acarbose is an α-glucosidase inhibitor produced by Actinoplanes sp. SE50/110 that is medically important due to its application in the treatment of type2 diabetes. In this work, a comprehensive proteome analysis of Actinoplanes sp. SE50/110 was carried out to determine the location of proteins of the acarbose (acb) and the putative pyochelin (pch) biosynthesis gene cluster. Therefore, a comprehensive state-of-the-art proteomics approach combining subcellular fractionation, shotgun proteomics and spectral counting to assess the relative abundance of proteins within fractions was applied. The analysis of four different proteome fractions (cytosolic, enriched membrane, membrane shaving and extracellular fraction) resulted in the identification of 1582 of the 8270 predicted proteins. All 22 Acb-proteins and 21 of the 23 Pch-proteins were detected. Predicted membrane-associated, integral membrane or extracellular proteins of the pch and the acb gene cluster were found among the most abundant proteins in corresponding fractions. Intracellular biosynthetic proteins of both gene clusters were not only detected in the cytosolic, but also in the enriched membrane fraction, indicating that the biosynthesis of acarbose and putative pyochelin metabolites takes place at the inner membrane.


BIOLOGICAL SIGNIFICANCE
Actinoplanes sp. SE50/110 is a natural producer of the α-glucosidase inhibitor acarbose, a bacterial secondary metabolite that is used as a drug for the treatment of type 2 diabetes, a disease which is a global pandemic that currently affects 387 million people and accounts for 11% of worldwide healthcare expenditures (www.idf.org). The work presented here is the first comprehensive investigation of protein localization and abundance in Actinoplanes sp. SE50/110 and provides an extensive source of information for the selection of genes for future mutational analysis and other hypothesis driven experiments. The conclusion that acarbose or pyochelin family siderophores are synthesized at the inner side of the cytoplasmic membrane determined from this work, indicates that studying corresponding intermediates will be challenging. In addition to previous studies on the genome and transcriptome, the work presented here demonstrates that the next omic level, the proteome, is now accessible for detailed physiological analysis of Actinoplanes sp. SE50/110, as well as mutants derived from this and related species.