LLukas22/scidocs huggingface dataset:
International Study to Predict Optimized Treatment for Depression (iSPOT-D), a randomized clinical trial: rationale and protocol

BACKGROUND
Clinically useful treatment moderators of Major Depressive Disorder (MDD) have not yet been identified, though some baseline predictors of treatment outcome have been proposed. The aim of iSPOT-D is to identify pretreatment measures that predict or moderate MDD treatment response or remission to escitalopram, sertraline or venlafaxine; and develop a model that incorporates multiple predictors and moderators.


METHODS/DESIGN
The International Study to Predict Optimized Treatment - in Depression (iSPOT-D) is a multi-centre, international, randomized, prospective, open-label trial. It is enrolling 2016 MDD outpatients (ages 18-65) from primary or specialty care practices (672 per treatment arm; 672 age-, sex- and education-matched healthy controls). Study-eligible patients are antidepressant medication (ADM) naïve or willing to undergo a one-week wash-out of any non-protocol ADM, and cannot have had an inadequate response to protocol ADM. Baseline assessments include symptoms; distress; daily function; cognitive performance; electroencephalogram and event-related potentials; heart rate and genetic measures. A subset of these baseline assessments are repeated after eight weeks of treatment. Outcomes include the 17-item Hamilton Rating Scale for Depression (primary) and self-reported depressive symptoms, social functioning, quality of life, emotional regulation, and side-effect burden (secondary). Participants may then enter a naturalistic telephone follow-up at weeks 12, 16, 24 and 52. The first half of the sample will be used to identify potential predictors and moderators, and the second half to replicate and confirm.


DISCUSSION
First enrolment was in December 2008, and is ongoing. iSPOT-D evaluates clinical and biological predictors of treatment response in the largest known sample of MDD collected worldwide.


TRIAL REGISTRATION
International Study to Predict Optimised Treatment - in Depression (iSPOT-D) ClinicalTrials.gov Identifier: NCT00693849. URL: http://clinicaltrials.gov/ct2/show/NCT00693849?term=International+Study+to+Predict+Optimized+Treatment+for+Depression&rank=1
Tangible products: redressing the balance between appearance and action

Over the past decade, our group has approached interaction design from an industrial design point of view. In doing so, we focus on a branch of design called “formgiving” Whilst formgiving is somewhat of a neologism in English, many other European languages do have a separate word for form-related design, including German (Gestaltung), Danish (formgivnin), Swedish (formgivning) and Dutch (vormgeving). . Traditionally, formgiving has been concerned with such aspects of objects as form, colour, texture and material. In the context of interaction design, we have come to see formgiving as the way in which objects appeal to our senses and motor skills. In this paper, we first describe our approach to interaction design of electronic products. We start with how we have been first inspired and then disappointed by the Gibsonian perception movement [1], how we have come to see both appearance and actions as carriers of meaning, and how we see usability and aesthetics as inextricably linked. We then show a number of interaction concepts for consumer electronics with both our initial thinking and what we learnt from them. Finally, we discuss the relevance of all this for tangible interaction. We argue that, in addition to a data-centred view, it is also possible to take a perceptual-motor-centred view on tangible interaction. In this view, it is the rich opportunities for differentiation in appearance and action possibilities that make physical objects open up new avenues to meaning and aesthetics in interaction design. Whilst formgiving is somewhat of a neologism in English, many other European languages do have a separate word for form-related design, including German (Gestaltung), Danish (formgivnin), Swedish (formgivning) and Dutch (vormgeving).
Anatomic bladder neck preservation during robotic-assisted laparoscopic radical prostatectomy: description of technique and outcomes.

BACKGROUND
Robotic-assisted laparoscopic radical prostatectomy (RALP) has been rapidly adopted despite a daunting learning curve with bladder neck dissection as a challenging step for newcomers.


OBJECTIVE
To describe an anatomic, reproducible technique of bladder neck preservation (BNP) and associated perioperative and long-term outcomes.


DESIGN, SETTINGS, AND PARTICIPANTS
From September 2005 to May 2009, data from 619 consecutive RALP were prospectively collected and compared on the basis of bladder neck dissection technique with 348 BNP and 271 standard technique (ST).


SURGICAL PROCEDURE
RALP with BNP.


MEASUREMENTS
Tumor characteristics, perioperative complications, and post-operative urinary control were evaluated at 4, 12 and 24 months using (1) the Expanded Prostate Cancer Index (EPIC) urinary function scale scored from 0-100; and (2) continence defined as zero pads per day.


RESULTS AND LIMITATIONS
Mean age for BNP versus ST was 57.1±6.6 yr versus 58.9±6.7 yr (p=0.033), while complication rates did not vary significantly by technique. Estimated blood loss was 183.7±95.8 ml versus 224.6±108 ml (p=0.938) in men who underwent BNP versus ST. The overall positive margin rate was 12.8%, which did not differ at the prostate base for BNP versus ST (1.4% vs. 2.2%, p=0.547). Mean urinary function scores for BNP versus ST at 4, 12, and 24 mo were 64.6 versus 57.2 (p=0.037), 80.6 versus 79.0 (p=0.495), and 94.1 versus 86.8 (p<0.001). Similarly, BNP versus ST continence rates at 4, 12, and 24 mo were 65.6% versus 26.5% (p<0.001), 86.4% versus 81.4% (p=0.303), and 100% versus 96.1% (p=0.308).


CONCLUSIONS
BNP versus ST is associated with quicker recovery of urinary function and similar cancer control.
A phase I/II trial of rAd/p53 (SCH 58500) gene replacement in recurrent ovarian cancer

Purpose: To determine the safety, gene transfer, host immune response, and pharmacokinetics of a replication-deficient adenovirus encoding human, recombinant, wild-type p53 (SCH 58500) delivered into the peritoneal cavity (i.p.) alone and sequentially in combination with platinum-based chemotherapy, of patients with recurrent ovarian, primary peritoneal, or fallopian tube cancer containing aberrant or mutant p53. Methods: SCH 58500 was administered i.p. to three groups of patients with heavily pretreated recurrent disease. Group 1 (n=17) received a single dose of SCH 58500 escalated from 7.5×1010 to 7.5×1012 particles. Group 2 (n=9) received two or three doses of SCH 58500 given alone for one cycle, and then with chemotherapy for two cycles. The SCH 58500 dose was further escalated to 2.5×1013 particles/dose in group 2. A third group (n=15) received a 5-day regimen of SCH 58500 given at 7.5×1013 particles/dose per day i.p. alone for cycle 1 and then with intravenous carboplatin/paclitaxel chemotherapy for cycles 2 and 3. Results: No dose-limiting toxicity resulted from the delivery of 236/287 (82.2%) planned doses of SCH 58500. Fever, hypotension abdominal complaints, nausea, and vomiting were the most common adverse events. Vector-specific transgene expression in tumor was documented by RT-PCR in cells from both ascitic fluid and tissue biopsies. Despite marked increases in serum adenoviral antibody titers, transgene expression was measurable in 17 of 20 samples obtained after two or three cycles of SCH 58500. Vector was detectable in peritoneal fluid by 24 hours and persisted for as long as 7 days whereas none was detected in urine or stool. There was poor correlation between CT scans and CA125 responses. CA125 responses, defined as a greater than 50% decrement in serum CA125 from baseline, were documented in 8 of 16 women who completed three cycles of the multidose regimen. Conclusion: CT scans are not a valid measure of response to i.p. SCH 58500 due to extensive adenoviral-induced inflammatory changes. Intraperitoneal SCH 58500 is safe, well tolerated, and combined with platinum-based chemotherapy can be associated with a significant reduction of serum CA125 in heavily pretreated patients with recurrent ovarian, primary peritoneal, or fallopian tube cancer.
Comparison between NSAID and intra-articular corticosteroid injection in frozen shoulder of diabetic patients; a randomized clinical trial.

INTRODUCTION
Frozen shoulder or adhesive capsulitis is a relatively common encountered musculo-skeletal disease in which arouses following soft tissue involvement of glenohumeral joint and presents with pain and limitation of shoulder' active and passive motions. The incidence of frozen shoulder among diabetic patients is about 10-20%, stiffness in such patients is more severe and should be managed actively. Local Glucocorticoid injection, NSAIDs and physiotherapy each can relief the symptoms. The aim of this study was to compare the efficacy of glenohumeral injection of Glucocorticoid with NSAIDs in frozen shoulder of diabetic patients.


METHOD
The randomized clinical trial study conducted during Feb 2009-Aug 2010 on diabetic patients with frozen shoulder that were referred to rheumatology and endocrinology clinics, Yazd, Iran. Diagnostic criteria of capsulitis were pain of shoulder and range of motion limitation in all directions. The patients were divided into 2 groups, patients of first group received NSAID while the latter group were undergone intra-articular corticosteroid injection. After 1 week, home exercise was done for both group and evaluation of the patients after first visit was done likewise 2nd, 6th, 12th and 24th weeks. All registered data were transformed into SPSS-15 software and analyzed.


RESULTS
Totally 57 patients (19 males (33.3%) and 38 females (66.7%) were included in the analysis. There was no significant difference between sex (P=0.4) and age (P=0.19) of patients. No significant relation was detected between 2 groups after 24 weeks according to range of motion in flexion (P=0.51), abduction (P=0.76), external rotation (0.12) and internal rotation (P=0.91). Also any significant difference in pain score was not detected (P=0.91).


CONCLUSION
Based on our study, both intra-articular corticosteroid and NSAID are effective in treatment of adhesive capsulitis and there is no significant difference between efficacies of these 2 treatment modalities in diabetic patients.
Combined genetic and transcriptional profiling of acute myeloid leukemia with normal and complex karyotypes.

BACKGROUND AND OBJECTIVES
Acute myeloid leukemia (AML) is a heterogeneous group of diseases. Patients with a normal karyotype constitute the largest single group; multiple chromosome rearrangements involving three or more chromosomes occur in 5 10% of AML patients. The pathophysiologic mechanisms underlying both groups are largely unknown. In the current study, we have systematically combined transcriptional profiles with cytogenetic data from 15 AML patients with either normal or complex karyotypes.


DESIGN AND METHODS
The expression profiles were investigated by unsupervised hierarchical clustering, supervised cluster analysis, and comparative genomic microarray analysis. In addition, the samples were analyzed by G-banding and/or spectral karyotyping and comparative genomic hybridization.


RESULTS
Our results show that AML with complex karyotypes exhibit a gene expression profile that is specific to this group of patients. The differentially expressed genes included several located on 5q and 7q, as well as genes involved in controlling cell division. We also found that DNA gains and losses caused by multiple chromosome rearrangements result in altered gene expression in a gene-dosage-dependent manner.


INTERPRETATION AND CONCLUSIONS
These data provide insight into the mechanisms of multiple chromosome rearrangements and further demonstrate that the expression patterns of AML are strongly linked to the karyotypic status, even for the relatively undefined cytogenetic subgroup AML with complex karyotype.
Broadband ESD protection circuits in CMOS technology

Two broadband circuits for I/O protection employ on-chip T-coil networks and standard ESD devices. Fabricated in 0.18 /spl mu/m CMOS technology, the input and output circuits tolerate 1000 V and 800 V, respectively, and introduce 3 dB eye closure at 10 Gb/s.
Constructivism in Theory and Practice: Toward a Better Understanding

Although constructivism is a concept that has been embraced my many teachers over the past 15 years, the meanings that are attached to this term are varied and often inadequately understood. Teachers need to have a sound understanding of what constructivism means to evaluate its promise and to use it knowledgeably and effectively. This paper explicates some of the theoretical background of constructivism and then presents a detailed example in which a traditional classroom lesson and a constructivist version of the same lesson are described and analyzed. Also discussed are pervasive myths and important instructional issues of this widely advocated and increasingly popular philosophical framework for teaching across the entire K-12 curriculum.
Fusion of color and infrared video for moving human detection

We approach the task of human silhouette extraction from color and thermal image sequences using automatic image registration. Image registration between color and thermal images is a challenging problem due to the difficulties associated with finding correspondence. However, the moving people in a static scene provide cues to address this problem. In this paper, we propose a hierarchical scheme to automatically find the correspondence between the preliminary human silhouettes extracted from synchronous color and thermal image sequences for image registration. Next, we discuss strategies for probabilistically combining cues from registered color and thermal images for improved human silhouette detection. It is shown that the proposed approach achieves good results for image registration and human silhouette extraction. Experimental results also show a comparison of various sensor fusion strategies and demonstrate the improvement in performance over nonfused cases for human silhouette extraction. 2006 Published by Elsevier Ltd on behalf of Pattern Recognition Society.
An empirical investigation of employee portal success

Employee portals are utilized by many companies to improve companies’ information exchange, communication, and employee collaboration, as well as to better support their business processes. Owing to limited IT budgets and the need to justify investments in employee portals, assessing the benefits of these is an important field in research and practice. Thus, the purpose of this study is to gain a better understanding of employee portal success. We introduce a theoretical model for this that is based on the DeLone and McLean IS Success Model. Furthermore, we develop hypotheses regarding the associations between different models’ success dimensions and test them using more than 10,000 employees’ responses collected in a survey of 22 companies. Our results indicate that besides the factors contributing to IS success in general, other success dimensions – like the quality of the collaboration and process support – have to be considered when aiming for a successful employee portal. The study’s findings make it possible for practitioners to understand the levers with which to improve their employee portals. By empirically validating a comprehensive success model for employee portals, the study’s results advance theoretical development in the area of collaboration-centered systems and present a basis for further research in this field. 2010 Elsevier B.V. All rights reserved.
Development of children born to mothers with cancer during pregnancy: comparing in utero chemotherapy-exposed children with nonexposed controls.

OBJECTIVE
Cancer is diagnosed in approximately 1 per 1000 pregnant women. Lifesaving cancer therapy given to the mother during pregnancy appears in conflict with the interest of the developing fetus. Often, termination of pregnancy is suggested but has not been proven in any type of cancer to improve maternal prognosis, while very few studies have documented the long-term effects of in utero chemotherapy exposure on child outcome. To counsel patients about the risk of continuing a pregnancy while undergoing cancer treatment, we performed developmental testing to provide more detailed follow-up on children exposed in utero to chemotherapy.


STUDY DESIGN
Mother-infant pairs, enrolled in the Cancer and Pregnancy Registry, were offered developmental testing for children who were ≥18 months of age. Based on age, the Bayley Scales of Infant Development-Third Edition, the Wechsler Preschool and Primary Scale of Intelligence-Revised, the Wechsler Intelligence Scale for Children, Third Edition, or the Wechsler Individual Achievement Test was administered. All parents or primary caregivers completed the Child Behavior Checklist, a parent questionnaire to assess behavior and emotional issues. Results of children exposed to chemotherapy before delivery were compared with children whose mothers were also diagnosed with cancer during pregnancy but did not receive chemotherapy before delivery.


RESULTS
No significant differences were noted in cognitive skills, academic achievement, or behavioral competence between the chemotherapy-exposed group and the unexposed children. Of children, 95% scored within normal limits on cognitive assessments; 71% and 79% of children demonstrated at or above age equivalency in mathematics and reading scores, respectively; and 79% of children scored within normal limits on measures of behavior. Older children had significantly higher rates of internalizing behavior problems.


CONCLUSION
We could not demonstrate a significant difference in cognitive ability, school performance, or behavioral competence for children exposed to chemotherapy in utero compared with nonexposed controls. The majority of these children scored within normal limits on all developmental measures. Premature birth was more prevalent in the chemotherapy-exposed group yet did not predict developmental outcome. Older children in the sample demonstrated higher rates of internalizing behavior problems.
Propostas para minimizar os riscos de acidentes de trânsito envolvendo crianças e adolescentes

This paper analyses traffic safety problems concerning children and adolescents. It proposes a programme intended to prevent traffic accidents, including measures related to urban aspects and to traffic education, engineering and enforcement. The programme proposed aims at preventing pedestrian accidents and includes a traffic accident data system, the checking of all pedestrian routes and main crossings, with special attention to traffic lights, traffic education actions, blackspot treatment, remedial measures directed to pavements, enforcement and rescue services with medical care for the injured. The analyses focusing on traffic education practice in Brazil has indicated that it will not promote changes to users’ behaviour. Therefore, the article points out the basis for a new approach.
Carbon stocks of mangroves and losses arising from their conversion to cattle pastures in the Pantanos de Centla, Mexico

The conservation of mangroves and other coastal “blue carbon” ecosystems is receiving heightened attention because of recognition of their high ecosystem carbon stocks as well as vast areas undergoing land conversion. However, few studies have paired intact mangroves with degraded sites to determine carbon losses due to land conversion. To address this gap we quantified total ecosystem carbon stocks in mangroves and cattle pastures formed from mangroves in the large wetland complex of the Pantanos de Centla in SE Mexico. The mean total ecosystem carbon stocks of fringe and estuarine tall mangroves was 1358 Mg C/ha. In contrast the mean carbon stocks of cattle pastures was 458 Mg C/ha. Based upon a biomass equivalence of losses from the top 1 m of mangrove soils, the losses in carbon stocks from mangrove conversion are conservatively estimated at 1464 Mg CO2e/ha. These losses were 7-fold that of emissions from tropical dry forest to pasture conversion and 3-fold greater than emissions from Amazon forest to pasture conversion. However, we found that limiting ecosystem carbon stocks differences to the surface 1 m or even 2 m soil depth will miss losses that occurred from deeper horizons. Mangrove conversion to other land uses comes at a great cost in terms of greenhouse gas emissions as well losses of other important ecosystem services.
COMMENT MINING, POPULARITY PREDICTION, AND SOCIAL NETWORK ANALYSIS by

...........................................................................................................................7 Chapter 1: Introduction ................................................................................................8 1.1. Motivation ..................................................................................................................9 1.2. Problem Hypothesis .................................................................................................11 1.3. Contributions............................................................................................................11 1.4. Thesis Outline ..........................................................................................................11 Chapter 2 : Background ...............................................................................................13 2.1. Social Networks .......................................................................................................13 2.2. Implicit versus Explicit Social Network Formations ...............................................14 2.3. Social Network Analysis versus Dynamic Network Analysis .................................15 2.4. Related Research ......................................................................................................16 2.5. Social Bookmarking and Digg Network ..................................................................18 Chapter 3: User Characterization ..............................................................................21 3.1. Network Description and Statistics ..........................................................................21 3.2. Degree Distribution ..................................................................................................22 3.3. Egonet Analysis .......................................................................................................23 3.4. User Membership Analysis ......................................................................................27 Chapter 4: Comparative Analysis of Network Formations .....................................31 4.