LLukas22/scidocs huggingface dataset:
EMailAnalyzer : an e-mail mining plug-in for the ProM framework

Increasingly information systems log historic information in a systematic way. Workflow management systems, but also ERP, CRM, SCM, and B2B systems often provide a so-called “event log”, i.e., a log recording the execution of activities. Thus far, process mining has been focusing on such structured event logs resulting in powerful analysis techniques and tools for discovering process, control, data, organizational, and social structures from event logs. Unfortunately, many work processes are not supported by systems providing structured logs. Instead very basic tools such as a text editors, spreadsheets, and e-mail are used. This report explores the application of process mining to e-mail, i.e., unstructured or semi-structured e-mail messages are converted in event logs suitable for the application of process mining tools. This report presents the tool EMailAnalyzer which analyzes and transforms e-mail messages in MS Outlook to a format that can be used by our process mining tools. The main innovative aspect of this work is that our analysis is not restricted to the social network, the main goal is to discover interaction patterns and processes.
Soft-tissue and cortical-bone thickness at orthodontic implant sites.

INTRODUCTION
To obtain sufficient stability of implants, the thickness of the soft tissue and the cortical bone in the placement site must be considered. However, the literature contains few anatomical studies of orthodontic implants.


METHODS
To measure soft-tissue and cortical-bone thicknesses, maxillae from 23 Korean cadavers were decalcified, and buccopalatal cross-sectional specimens were obtained. These specimens were made at 3 maxillary midpalatal suture areas: the interdental area between the first and second premolars (group 1), the interdental area between the second premolar and the first molar (group 2), and the interdental area between the first and second molars (group 3).


RESULTS
In all groups, buccal soft tissues were thickest closest to and farthest from the cementoenamel junction (CEJ) and thinnest in the middle. Palatal soft-tissue thickness increased gradually from the CEJ toward the apical region in all groups. Buccal cortical-bone was thickest closest to and farthest from the CEJ and thinnest in the middle in groups 1 and 2. Palatal cortical-bone thickness was greatest 6 mm apical to the CEJ in groups 1 and 3, and 2 mm apical to the CEJ in group 2. Along the midpalatal suture, palatal mucosa remained uniformly 1 mm thick posterior to the incisive papilla.


CONCLUSIONS
Surgical placement of miniscrew implants for orthodontic anchorage in the maxillary molar region requires consideration of the placement site and angle based on anatomical characteristics.
Ultrafiltration in decompensated heart failure with cardiorenal syndrome.

BACKGROUND
Ultrafiltration is an alternative strategy to diuretic therapy for the treatment of patients with acute decompensated heart failure. Little is known about the efficacy and safety of ultrafiltration in patients with acute decompensated heart failure complicated by persistent congestion and worsened renal function.


METHODS
We randomly assigned a total of 188 patients with acute decompensated heart failure, worsened renal function, and persistent congestion to a strategy of stepped pharmacologic therapy (94 patients) or ultrafiltration (94 patients). The primary end point was the bivariate change from baseline in the serum creatinine level and body weight, as assessed 96 hours after random assignment. Patients were followed for 60 days.


RESULTS
Ultrafiltration was inferior to pharmacologic therapy with respect to the bivariate end point of the change in the serum creatinine level and body weight 96 hours after enrollment (P=0.003), owing primarily to an increase in the creatinine level in the ultrafiltration group. At 96 hours, the mean change in the creatinine level was -0.04±0.53 mg per deciliter (-3.5±46.9 μmol per liter) in the pharmacologic-therapy group, as compared with +0.23±0.70 mg per deciliter (20.3±61.9 μmol per liter) in the ultrafiltration group (P=0.003). There was no significant difference in weight loss 96 hours after enrollment between patients in the pharmacologic-therapy group and those in the ultrafiltration group (a loss of 5.5±5.1 kg [12.1±11.3 lb] and 5.7±3.9 kg [12.6±8.5 lb], respectively; P=0.58). A higher percentage of patients in the ultrafiltration group than in the pharmacologic-therapy group had a serious adverse event (72% vs. 57%, P=0.03).


CONCLUSIONS
In a randomized trial involving patients hospitalized for acute decompensated heart failure, worsened renal function, and persistent congestion, the use of a stepped pharmacologic-therapy algorithm was superior to a strategy of ultrafiltration for the preservation of renal function at 96 hours, with a similar amount of weight loss with the two approaches. Ultrafiltration was associated with a higher rate of adverse events. (Funded by the National Heart, Lung, and Blood Institute; ClinicalTrials.gov number, NCT00608491.).
Manson's point: A facial landmark to identify the facial artery.

INTRODUCTION
The anatomy of the facial artery, its tortuosity, and branch patterns are well documented. To date, a reliable method of identifying the facial artery, based on surface landmarks, has not been described. The purpose of this study is to characterize the relationship of the facial artery with several facial topographic landmarks, and to identify a location where the facial artery could predictably be identified.


METHODS
Following institutional review board approval, 20 hemifacial dissections on 10 cadaveric heads were performed. Distances from the facial artery to the oral commissure, mandibular angle, lateral canthus, and Manson's point were measured. Distances were measured and confirmed clinically using Doppler examination in 20 hemifaces of 10 healthy volunteers.


RESULTS
Manson's point identifies the facial artery with 100% accuracy and precision, within a 3 mm radius in both cadaveric specimens and living human subjects. Cadaveric measurements demonstrated that the facial artery is located 19 mm ± 5.5 from the oral commissure, 31 mm ± 6.8 from the mandibular angle, 92 mm ± 8.0 from the lateral canthus. Doppler examination on healthy volunteers (5 male, 5 female) demonstrated measurements of 18 mm ± 4.0, 50 mm ± 6.4, and 79 mm ± 8.2, respectively.


CONCLUSIONS
The identification of the facial artery is critical for the craniofacial surgeon in order to avoid inadvertent injury, plan for local flaps, and in preparation of a recipient vessel for free tissue microvascular reconstruction. Manson's point can aid the surgeon in consistently indentifying the facial artery.
Intervenable factors associated with suicide risk in transgender persons: a respondent driven sampling study in Ontario, Canada

BACKGROUND
Across Europe, Canada, and the United States, 22-43 % of transgender (trans) people report a history of suicide attempts. We aimed to identify intervenable factors (related to social inclusion, transphobia, or sex/gender transition) associated with reduced risk of past-year suicide ideation or attempt, and to quantify the potential population health impact.


METHODS
The Trans PULSE respondent-driven sampling (RDS) survey collected data from trans people age 16+ in Ontario, Canada, including 380 who reported on suicide outcomes. Descriptive statistics and multivariable logistic regression models were weighted using RDS II methods. Counterfactual risk ratios and population attributable risks were estimated using model-standardized risks.


RESULTS
Among trans Ontarians, 35.1 % (95 % CI: 27.6, 42.5) seriously considered, and 11.2 % (95 % CI: 6.0, 16.4) attempted, suicide in the past year. Social support, reduced transphobia, and having any personal identification documents changed to an appropriate sex designation were associated with large relative and absolute reductions in suicide risk, as was completing a medical transition through hormones and/or surgeries (when needed). Parental support for gender identity was associated with reduced ideation. Lower self-reported transphobia (10(th) versus 90(th) percentile) was associated with a 66 % reduction in ideation (RR = 0.34, 95 % CI: 0.17, 0.67), and an additional 76 % reduction in attempts among those with ideation (RR = 0.24; 95 % CI: 0.07, 0.82). This corresponds to potential prevention of 160 ideations per 1000 trans persons, and 200 attempts per 1,000 with ideation, based on a hypothetical reduction of transphobia from current levels to the 10(th) percentile.


CONCLUSIONS
Large effect sizes were observed for this controlled analysis of intervenable factors, suggesting that interventions to increase social inclusion and access to medical transition, and to reduce transphobia, have the potential to contribute to substantial reductions in the extremely high prevalences of suicide ideation and attempts within trans populations. Such interventions at the population level may require policy change.
[Effects of acute octreotide infusion on renal function in patients with cirrhosis and portal hypertension].

BACKGROUND
Octreotide is used in the treatment of acute variceal bleeding, based on its inhibitory effects of post-prandial splanchnic hyperemia and splanchnic venoconstriction. The consequences of these haemodynamic changes on renal circulation are not well known in cirrhotic patients.


AIM
To evaluate the effects of acute octreotide administration on several parameters of renal function, including free water clearance, in patients with cirrhosis with or without ascites.


PATIENTS AND METHODS
Twenty cirrhotic patients, Child-Pugh A orB, with or without ascites, with esophageal varices, normal renal function and free of medications (vasoactive drugs or diuretics) were assigned to 2 different protocols. Protocol 1: 10 patients were randomized to receive octreotide or placebo, as a bolus followed by a continuous infusion. Glomerular filtration rate (GFR) and renal plasma flow (PRF) were measured, in basal conditions and during the drug or placebo administration. Protocol 2: 10 additional patients were randomized in the same way and free water clearance and urinary sodium excretion were again measured in the basal period and during the drug or placebo infusion.


RESULTS
After octreotide or placebo administration no significant changes were observed neither in GFR nor in PRF. The free water clearance decreased significantly during octreotide administration (3.12 ml/min+/-1.04 SE vs 0.88+/-0.39, p<.03). In both protocols no changes in mean arterial pressure were observed.


CONCLUSIONS
Acute administration of octreotide to cirrhotic patients with portal hypertension, with or without ascites, did not produce any change in glomerular filtration rate or in estimated renal plasm blood flow. However the free water clearance decreased significantly. This effect, under chronic administration, could be clinically important and deserves further studies.
[Diagnostic yield and safety of bronchoscopic cryotechnique in routine diagnostics for suspected lung cancer].

BACKGROUND
Cryoprobes with flexible catheters are an additional important tool for endobronchial interventional therapy and histologic diagnosis. Different studies compared the diagnostic effectiveness and complications to the forceps as a standard. However, routine endoscopic procedures require a combined use of different methods in order to achieve the highest diagnostic yield. We investigated the impact of cryotechnique in comparison with combined diagnostic tools during routine diagnostics of malignant tumors.


PATIENTS AND METHODS
A consecutive series of patients undergoing routine diagnostic for lung cancer was included over a 30 months period (n = 469). The use of the cryotechnique, the complication rates and diagnostic value were prospectively documented. Cryotechnique was used on top of conventional technologies.


RESULTS
A histologic proof of tumor by cryotechnique in centrally located tumors was delivered more frequently compared to forceps biopsies alone (81.4 versus 59.9% and 66.2 versus 37.7% in peripheral lesions). However, when the other non-cryotechniques were taken into account, the value was reduced in central probes (7.4%; p = 0.02), but remained high for peripheral findings (19.3%; p < 0.002). The frequency of complications seemed unchanged, however severe bleeding occurred.


CONCLUSION
The cryotechnique bears high diagnostic potential beside its therapeutic value, also in routine investigations. The changed complication profile of this technology needs to be addressed in the informed consent and secured airway management may be helpful.
Image-Dependent Gamut Mapping as Optimization Problem

We explore the potential of image-dependent gamut mapping as a constrained optimization problem. The performance of our new approach is compared to standard reference gamut mapping algorithms in psycho-visual tests.
Impact of inadequate adherence on response to subcutaneously administered anti-tumour necrosis factor drugs: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort

OBJECTIVE
Non-adherence to DMARDs is common, but little is known about adherence to biologic therapies and its relationship to treatment response. The purpose of this study was to investigate the association between self-reported non-adherence to s.c. anti-TNF therapy and response in individuals with RA.


METHODS
Participants about to start s.c. anti-TNF therapy were recruited to a large UK multicentre prospective observational cohort study. Demographic information and disease characteristics were assessed at baseline. Self-reported non-adherence, defined as whether the previous due dose of biologic therapy was reported as not taken on the day agreed with the health care professional, was recorded at 3 and 6 months following the start of therapy. The 28-joint DAS (DAS28) was recorded at baseline and following 3 and 6 months of therapy. Multivariate linear regression was used to examine these relationships.


RESULTS
Three hundred and ninety-two patients with a median disease duration of 7 years [interquartile range (IQR) 3-15] were recruited. Adherence data were available in 286 patients. Of these, 27% reported non-adherence to biologic therapy according to the defined criteria at least once within the first 6-month period. In multivariate linear regression analysis, older age, lower baseline DAS28 and ever non-adherence at either 3 or 6 months from baseline were significantly associated with a poorer DAS28 response at 6 months to anti-TNF therapy.


CONCLUSION
Patients with RA who reported not taking their biologic on the day agreed with their health care professional showed poorer clinical outcomes than their counterparts, emphasizing the need to investigate causes of non-adherence to biologics.
Growth disturbance following ACL reconstruction with use of an epiphyseal femoral tunnel: a case report.

A nterior cruciate ligament (ACL) tears in skeletally immature patients are increasing in prevalence. This appears to be the result of a heightened suspicion for such injuries, more readily available imaging, and the ever-increasing physical demands and competitiveness of organized youth sports. As a result, there is increased interest in early ACL reconstruction to potentially prevent further intra-articular damage to the knee. Multiple surgical techniques for ACL reconstruction described for adults are not appropriate in skeletally immature patients because they involve large drill holes across the physis, fixation or bone blocks that cross the physis, or tensioning of a graft across the physis, all of which have been shown to result in growth disturbances. Because of these concerns, multiple surgical techniques to address ACL tears in patients with open physes have been described, including primary repair, extraarticular tenodesis, transphyseal reconstruction, partial transphyseal reconstruction, and physeal sparing techniques. Growth disturbances have been reported with the use of most of these techniques. Anderson described a technique of ACL reconstruction that avoids drilling tunnels across the physis. Theoretically, this should decrease the incidence of growth disturbance following ACL reconstruction in skeletally immature patients. With this technique, both the femoral and the tibial tunnels are drilled entirely within the epiphysis, and an all-soft-tissue graft is used for the reconstruction. Good results were found in twelve patients at the time of follow-up, two to eight years postoperatively, and to our knowledge a growth disturbance has never been reported after the use of this technique. Here, we describe a case of distal femoral valgus angulation associated with use of an epiphyseal femoral tunnel for a revision ACL reconstruction in an immature patient. The patient and his family consented to, and institutional review board approval was obtained for, presentation of this case.
Laparoscopic rectal resection with anal sphincter preservation for rectal cancer

Total mesorectal excision (TME) is the surgical gold standard treatment for middle and low third rectal carcinoma. Laparoscopy has gradually become accepted for the treatment of colorectal malignancy after a long period of questions regarding its safety. The purposes of this study were to examine prospectively our experience with laparoscopic TME and high rectal resections, to evaluate the surgical outcomes and oncologic adequacy, and to discuss the role of this procedure in the treatment of rectal cancer. Between December 1992 and December 2004, all patients who underwent elective laparoscopic sphincter preserving rectal resection for rectal cancer were enrolled prospectively in this study. Data collection included preoperative, operative, postoperative and oncologic results with long-term follow-up. A total of 218 patients were operated on during the study period: 142 patients underwent laparoscopic TME and 76 patients underwent anterior resection. Of the TME patients, 122 patients were operated using the double-stapling technique, and 20 patients underwent colo-anal anastomosis with hand-sewn sutures. Mean operative time was 138 min (range, 107–205), and mean blood loss was 120 ml (range, 30–350). Conversion to open surgery occurred in 26 cases (12%). Mortality rate during the first 30 days was 1%. Anastomotic leaks were observed in 10.5% of the patients. Of these, 61.9% needed reoperation and diverting stoma, and the rest were treated conservatively. Three patients had postoperative bleeding requiring relaparoscopy. Other minor complications (infection and urinary retention) occurred in 9.1% of patients. Mean ambulation time and mean hospital stay were 1.6 days (range, 1–5) and 6.4 days (range, 3–28) , respectively. Patients were followed for a mean period of 57 months. No port site metastases were observed during follow-up. The recurrence rate was 6.8 %. Overall survival rate was 67% after 5 years and 53.5% after 10 years. Laparoscopic anterior resection and TME with anal sphincter preservation for rectal cancer is feasible and safe. The short- and long-term outcomes reported in this series are comparable with those of conventional surgery.
Chapter 2 Developing a Sustainable Supply Chain Strategy

Long-term trends pose challenges for supply chain managers and make increasing requirements on the strategic management expertise of today’s companies. These trends include ongoing globalisation and the increasing intensity of competition, the growing demands of security, environmental protection and resource scarcity and, last but not least, the need for reliable, flexible and cost-efficient business systems capable of supporting customer differentiation. More than ever, modern supply chain managers are confronted with dynamic and complex supply chains and therefore with trends and developments that are hard to predict. In years to come, supply chain management will therefore take on additional strategic tasks that extend beyond its current more operational scope of activity. In order to respond to these changes and remain competitive, supply chain managers need to be able to identify and understand new sustainability issues in their company and business environment. This calls, especially in respect of global, international, and fragmented supply chains, not only for highly efficient supply chain operations, but also for networking skills that must continuously adapt to sustainability demands to create sustainable,
Neither cytochrome P450 family genes nor neuroendocrine factors could independently predict the SSRIs treatment in the Chinese Han population.

OBJECTIVE
This study was intended to explore the relationship between the genetic polymorphisms of the 8 single nucleotide polymorphisms (SNPs) at CYP genes, neuroendocrine factors and the response to selective serotonin reuptake inhibitors (SSRIs) in Chinese Han depressive patients.


METHOD
This was a 6-week randomized controlled trial consisting of 290 Chinese Han depressive patients treated with SSRIs. 8 SNPs of CYP450 genes and 7 neuroendocrine factors were detected. Allele and genotype frequencies were compared between responders and non-responders. The relationships between neuroendocrine factors and treatment response were also analyzed.


RESULTS
No significant differences were found in clinical features between 2 groups at the baseline. No statistical correlation was found between either the genotype or allele frequencies of SNPs in CYP1A2, CYP2C19, or CYP2D6 gene and the -efficacy of SSRIs. There were strong linkage disequilibria between rs4986894, rs1853205, and rs12767583 of CYP2C19 genes, and rs2472299, rs2472300 of CYP1A2 genes. No associations were found between the above haplotypes and the antidepressant response. No neuroendocrine factor was a significant predictor for a response to SSRI antidepressants independently. The combination of neuroendocrine factors, however, predicted the response by 76.1%.


CONCLUSION
There were no significant associations between the 6 SNPs of CYP gene polymorphisms and SSRI response. Neither cytochrome P450 family genes nor neuroendocrine factors independently predict the patients' response to the antidepressants separately. A combination of neuroendocrine factors, however, does have the potential to predict the response.
Responsive Supply Chain : A Competitive Strategy in a Networked Economy

Supply chain management (SCM) has been considered as the most popular operations strategy for improving organizational competitiveness in the twenty-first century. In the early 1990s, agile manufacturing (AM) gained momentum and received due attention from both researchers and practitioners. In the mid-1990s, SCM began to attract interest. Both AM and SCM appear to differ in philosophical emphasis, but each complements the other in objectives for improving organizational competitiveness. For example, AM relies more on strategic alliances/partnerships (virtual enterprise environment) to achieve speed and flexibility. But the issues of cost and the integration of suppliers and customers have not been given due consideration in AM. By contrast, cost is given a great deal of attention in SCM, which focuses on the integration of suppliers and customers to achieve an integrated value chain with the help of information technologies and systems. Considering the significance of both AM and SCM for firms to improve their performance, an attempt has been made in this paper to analyze both AM and SCM with the objective of developing a framework for responsive supply chain (RSC). We compare their characteristics and objectives, review the selected literature, and analyze some case experiences on AM and SCM, and develop an integrated framework for a RSC. The proposed framework can be employed as a competitive strategy in a networked economy in which customized products/services are produced with virtual organizations and exchanged using e-commerce. 2007 Elsevier Ltd. All rights reserved.