LLukas22/scidocs huggingface dataset:
Phosphor-Free Monolithic White-Light LED

Phosphor-free monolithic InGaN-based white-light LED has the advantages of simpler device process and potentially higher efficiency. Several techniques have been developed for implementing such white-light LEDs. Among them, the key issue is the growth of a high-quality high-indium InGaN/GaN quantum well (QW). An underlying InGaN layer growth technique is introduced for enhancing the crystal quality of a high-indium QW. To demonstrate the superior properties of a QW grown with this technique, a green LED is fabricated based on the underlying growth technique to compare with another LED of the same emission wavelength based on the conventional growth method. Then, the underlying growth technique is used to grow three yellow-emitting QWs of high efficiency. The yellow photons mix with blue light from an overgrown blue-emitting QW to produce white light. The improved properties of the phosphor-free monolithic white-light LED are discussed in detail.
Learning experience from the Coventry Community Personality Disorder Service

The Coventry Community Personality Disorder Service is a new service that has been developed successfully over the past two years, despite several challenges such as real difficulties with recruitment. This is a description of our model, its implementation and some of the emergent issues we encountered along the way.
Amitriptyline or not, that is the question: pharmacogenetic testing of CYP2D6 and CYP2C19 identifies patients with low or high risk for side effects in amitriptyline therapy.

BACKGROUND
Amitriptyline has been replaced in many countries by alternative and more expensive drugs based on claims of improved tolerability and toxicity and despite slightly reduced efficacy. Preliminary studies indicate that adverse effects could be linked to polymorphisms of drug-metabolizing enzymes, but information on their clinical impact remains scanty and includes mainly case reports. We conducted a prospective blinded two-center study seeking correlations between CYP2C19 and CYP2D6 genotypes, drug concentrations, adverse events, and therapy response.


METHODS
Fifty Caucasian inpatients with at least medium-grade depressive disorder received amitriptyline at a fixed dose of 75 mg twice a day. Blood samples for concentration monitoring of amitriptyline and nortriptyline were taken weekly until discharge along with evaluations of depression (Hamilton Depression Scale and Clinical Global Impression Scale) and side effect (Dosage Record and Treatment Emergent Symptoms Scale; DOTES) scores.


RESULTS
In a ROC analysis, nortriptyline but not amitriptyline concentrations correlated with side effects (DOTES sum score >or=5; area under the curve, 0.733; P = 0.008). Carriers of two functional CYP2D6 alleles had a significantly lower risk of side effects than carriers of only one functional allele (12.1% vs 76.5%; P = 0.00001). The lowest risk was observed for carriers of two functional CYP2D6 alleles combined with only one functional CYP2C19 allele [0 of 13 (0%) vs 9 of 11 (81.8%) for the high-risk group; P = 0.00004]. We found no correlations between drug concentrations or genotypes and therapeutic response.


CONCLUSIONS
Combined pharmacogenetic testing for CYP2D6 and CYP2C19 identifies patients with low risk for side effects in amitriptyline therapy and could possibly be used to individualize antidepressive regimens and reduce treatment cost. Identification of genotypes associated with slightly reduced intermediate metabolism may be more important than currently anticipated. It could also be the key to demonstrating cost-effectiveness for CYP2D6 genotyping in critical dose drugs.
High aquatic niche overlap in the newts Triturus cristatus and T. marmoratus (Amphibia, Urodela)

We studied spatial niche metrics of large-bodied newts (Triturus cristatus and T. marmoratus) in three breeding ponds in western France. Adults and larvae were sampled with underwater funnel traps. Larvae were identified to the species with diagnostic microsatellite DNA markers. The distribution of adult T. cristatus and T. marmoratus across pond regions differed in one out of six cases, no differences were observed between larvae (two ponds studied). Niche overlap and niche breadth indices across resource states defined as pond regions or individual traps were high (Schoener's C: pond regions 0.60–0.98, traps 0.35–0.71; Levins' B: pond regions 0.71–0.98, traps 0.35–0.76). Adults of large-bodied newts significantly differed in resource use from small-bodied newts (T. helveticus). The results are discussed in view of the occurrence of interspecific breeding attempts, and the unpredictable ecological characteristics of newt breeding ponds.
Bioavailability of phenolic acids

Two large classes of phenolic acids were comprised in this review: benzoic acid derivatives and cinnamic acid derivatives. They have been found to be very extended in fruits and vegetables at different concentrations. For example, hydroxycinnamic acids concentration was higher than that found for hydroxybenzoic acids. Concerning their consumption, hydroxycinnamic acids provide larger contributions to the total polyphenol intake than benzoic acid derivatives or flavonoids. This phenolic acid intake is led by the coffee intake since it has very rich concentrations in hydroxycinnamic acids. Moreover, several experimental and epidemiological studies report the protection of phenolic acids against various degenerative diseases. However, despite all these interesting attributions and even if phenolic acids are the main polyphenols consumed, their bioavailability has not received as attention as that flavonoids. This concept is an essential step to understand the health-promoting properties of phenolic acids and to serve as tool to design in vivo and in vitro experiments to know their biological properties. Therefore, a compilation of bioavailability data of phenolic acids have been presented here paying attention to the two types of phenolic acid bioavailability, direct and indirect derived from the direct phenolic acid and flavonoid consumption, respectively. Then, a new relevant concept which may be named as total bioavailability of phenolic acids includes the direct absorption and metabolism of phenolic acids from food consumption and phenolic acids bioavailability as a result of the cleavage on the main skeleton ring of flavonoids by the gut microflora.
Transmit/receive isolator for UHF RFID reader with wideband balanced directional coupler

A wideband balanced directional coupler for UHF RFID reader is proposed. The wideband balanced coupler has a high isolation feature insensitive to load variations. The transmit and receive isolation characteristic is achieved for UHF RFID band (860∼960 MHz). The proposed structure has an isolation of more than 45dB in the UHF RFID band according to the variations in matching.
Mobile web and cloud services enabling Internet of Things

The Internet of Things (IoT) represents a comprehensive environment that consists of a large number of sensors and mediators interconnecting heterogeneous physical objects to the Internet. IoT applications are prominent in many areas such as smart city, smart workplace, smart plants, smart agriculture and various ubiquitous computing areas. The research roadmap of IoT spans across vast domains such as mobile computing, wireless and sensor networks, service oriented computing, middleware, cloud computing and big data analytics, taking advantage of several recent breakthroughs in the respective domains. Primarily, the challenges associated with realization of IoT scenarios can be summarized across three layers: sensing and smart devices layer, connectivity layer and cloud layer. The first layer deals with the physical objects, including energy-efficient communication of the devices and developing the associated standards so that the interaction among the devices is seamless. The connectivity layer deals with the sensor data acquisition and provisioning, through gateways and sinks. The top cloud layer deals with resource provisioning for storage and processing of the acquired data, in extracting domain specific information. The participation of smart phones both as sensors and the gateways, brings in the scope for mobile web services and mobile cloud services, into this cloud based IoT architecture. The paper takes the cross-layered approach and tries to address the primary challenges of IoT through mobile web and cloud services. The paper also discusses the state of the art of each of the respective research domains along with scope for extensions and recent trends.
Original Article Development of functional biscuit from soy flour &rice bran

The research intended to explore the possibility of fortifying the soy flour and rice bran to formulate the functional biscuit which have the ability to improve the quality of food products due to various functional properties. Suplementation of wheat flour with soya and rice bran was tried at 10 %, 15%, 20%, 25% level each. Prepared biscuit is subjected to physical, Sensory and nutritional analysis to evaluate the suitability of biscuit for consumption. The width of biscuit decreases from 44 to 36.2 with increasing in the level of substitution of composite flour of rice bran and soya. Similar tread shown by spread radio. However, biscuit thickness increases from 9.2 to 10.6 with increasing level of substitution. Nine-Point Hedonic Score System was used for sensory evaluation of prepared biscuit which is generally decreases with increasing the level of substitution. From overall acceptability rating, 15% soy flour +15% rice bran incorporated biscuit obtained the highest rating compare to other treatments. At p≤0.05, there were no significant difference between the control treatment and best rated supplemented biscuit (70:15:15) in general preference of sensory rating. Nutritional evaluation of best rated supplemented biscuit were protein (15.7%), fat (19.5%), fiber (2.2%), moisture (3.6%). Thus supplementation of soy flour and rice bran at 15% level each, would improve the nutritional quality without adversely affecting the sensory parameters. © 2011 Universal Research Publications. All rights reserved
Treatment of Lennox-Gastaut syndrome: overview and recent findings

Lennox-Gastaut syndrome (LGS) is a rare, age-related syndrome, characterized by multiple seizure types, a specific electro-encephalographic pattern, and mental regression. However, published data on the etiology, evolution, and therapeutic approach of LGS are contradictory, partly because the precise definition of LGS used in the literature varies. In the most recent classification, LGS belongs to the epileptic encephalopathies and is highly refractory to all antiepileptic drugs. Numerous treatments, medical and non-medical, have been proposed and results mostly from open studies or case series have been published. Sometimes, patients with LGS are included in a more global group of patients with refractory epilepsy. Only 6 randomized double-blind controlled trials of medical treatments, which included patients with LGS, have been published. Overall, treatment is rarely effective and the final prognosis remains poor in spite of new therapeutic strategies. Co-morbidities need specific treatment. This paper summarizes the definition, diagnosis and therapeutic approach to LGS, including not only recognized antiepileptic drugs, but also "off label" medications, immune therapy, diet, surgery and some perspectives for the future.
Abstract commensurators of profinite groups

COMMENSURATORS OF PROFINITE GROUPS YIFTACH BARNEA, MIKHAIL ERSHOV, AND THOMAS WEIGEL Abstract. In this paper we initiate a systematic study of the abstract commensurators of profinite groups. The abstract commensurator of a profinite group G is a group Comm(G) which depends only on the commensurability class of G. We study various properties of Comm(G); in particular, we find two natural ways to turn it into a topological group. We also use Comm(G) to study topological groups which contain G as an open subgroup (all such groups are totally disconnected and locally compact). For instance, we construct a topologically simple group which contains the pro-2 completion of the Grigorchuk group as an open subgroup. On the other hand, we show that some profinite groups cannot be embedded as open subgroups of compactly generated topologically simple groups. Several celebrated rigidity theorems, such as Pink’s analogue of Mostow’s strong rigidity theorem for simple algebraic groups defined over local fields and the Neukirch-Uchida theorem, can be reformulated as structure theorems for the commensurators of certain profinite groups. In this paper we initiate a systematic study of the abstract commensurators of profinite groups. The abstract commensurator of a profinite group G is a group Comm(G) which depends only on the commensurability class of G. We study various properties of Comm(G); in particular, we find two natural ways to turn it into a topological group. We also use Comm(G) to study topological groups which contain G as an open subgroup (all such groups are totally disconnected and locally compact). For instance, we construct a topologically simple group which contains the pro-2 completion of the Grigorchuk group as an open subgroup. On the other hand, we show that some profinite groups cannot be embedded as open subgroups of compactly generated topologically simple groups. Several celebrated rigidity theorems, such as Pink’s analogue of Mostow’s strong rigidity theorem for simple algebraic groups defined over local fields and the Neukirch-Uchida theorem, can be reformulated as structure theorems for the commensurators of certain profinite groups.
The Impact of Stigma and Personal Experiences on the Help-Seeking Behaviors of Medical Students With Burnout.

PURPOSE
Because of the high prevalence of burnout among medical students and its association with professional and personal consequences, the authors evaluated the help-seeking behaviors of medical students with burnout and compared their stigma perceptions with those of the general U.S. population and age-matched individuals.


METHOD
The authors surveyed students at six medical schools in 2012. They measured burnout, symptoms of depression, and quality of life using validated instruments and explored help-seeking behaviors, perceived stigma, personal experiences, and attitudes toward seeking mental health treatment.


RESULTS
Of 2,449 invited students, 873 (35.6%) responded. A third of respondents with burnout (154/454; 33.9%) sought help for an emotional/mental health problem in the last 12 months. Respondents with burnout were more likely than those without burnout to agree or strongly agree with 8 of 10 perceived stigma items. Respondents with burnout who sought help in the last 12 months were twice as likely to report having observed supervisors negatively judge students who sought care (odds ratio [OR] 2.06 [95% confidence interval (CI) 1.25-3.39], P < .01). They also were more likely to have observed peers reveal a student's emotional/mental health problem to others (OR 1.63 [95% CI 1.08-2.47], P = .02). A smaller percentage of respondents would definitely seek professional help for a serious emotional problem (235/872; 26.9%) than of the general population (44.3%) and age-matched individuals (38.8%).


CONCLUSIONS
Only a third of medical students with burnout seek help. Perceived stigma, negative personal experiences, and the hidden curriculum may contribute.
Energy management in a parallel hybrid electric vehicle with a continuously variable transmission

This paper describes a control strategy for the energy management of a post-transmission parallel hybrid electric vehicle (PHEV) equipped with a continuously variable transmission (CVT). Results are presented highlighting the dynamic behavior of the model, as well as the fuel consumption normalized to a base case. A dynamic, forward simulation of a complete compact class vehicle including driver model and computer controller was written in Matlab / Simulink. Modeled vehicle components include: internal combustion engine, engine clutch, CVT, electric motor, lead-acid battery, vehicle driveline, hydraulic brakes, and the vehicle and tire dynamics.
Sevelamer is cost effective versus calcium carbonate for the first-line treatment of hyperphosphatemia in new patients to hemodialysis: a patient-level economic evaluation of the INDEPENDENT-HD study.

BACKGROUND
The recent multicenter, randomized, open-label INDEPENDENT study demonstrated that sevelamer improves survival in new to hemodialysis (HD) patients compared with calcium carbonate. The objective of this study was to determine the cost-effectiveness of sevelamer versus calcium carbonate for patients new to HD, using patient-level data from the INDEPENDENT study.


STUDY DESIGN
Cost-effectiveness analysis.


SETTING AND POPULATION
Adult patients new to HD in Italy.


MODEL, PERSPECTIVE, TIMEFRAME
A patient-level cost-effectiveness analysis was conducted from the perspective of the Servizio Sanitario Nazionale, Italy's national health service. The analysis was conducted for a 3-year time horizon. The cost of dialysis was excluded from the base case analysis.


INTERVENTION
Sevelamer was compared to calcium carbonate.


OUTCOMES
Total life years (LYs), total costs, and the incremental cost per LY gained were calculated. Bootstrapping was used to estimate confidence intervals around LYs, costs, and cost-effectiveness and to calculate the cost-effectiveness acceptability curve.


RESULTS
Sevelamer was associated with a gain of 0.26 in LYs compared to calcium carbonate, over the 3-year time horizon. Total drug costs were €3,282 higher for sevelamer versus calcium carbonate, while total hospitalization costs were €2,020 lower for sevelamer versus calcium carbonate. The total incremental cost of sevelamer versus calcium carbonate was €1,262, resulting in a cost per LY gained of €4,897. The bootstrap analysis demonstrated that sevelamer was cost effective compared with calcium carbonate in 99.4 % of 10,000 bootstrap replicates, assuming a willingness-to-pay threshold of €20,000 per LY gained.


LIMITATIONS
Data on hospitalizations was taken from a post hoc retrospective chart review of the patients included in the INDEPENDENT study. Patient quality of life or health utility was not included in the analysis.


CONCLUSIONS
Sevelamer is a cost-effective alternative to calcium carbonate for the first-line treatment of hyperphosphatemia in new to HD patients in Italy.
Plasma concentrations of estradiol in women suffering from schizophrenia treated with conventional versus atypical antipsychotics

BACKGROUND
Low estrogen levels leading to an elevated rate of menstrual dysfunctions such as amenorrhea and irregular menstruation have been described in women with schizophrenia and have often been attributed to antipsychotic-induced hyperprolactinemia. However, there is some evidence that "hypoestrogenism" in schizophrenic women does not occur exclusively under medication with hyperprolactinemia-inducing antipsychotics. While the precise mechanism of low estrogen levels in schizophrenic women has not been elucidated yet, "hypoestrogenism" is of clinical relevance because estrogen seems to endow an antipsychotic-like effect in schizophrenia and thus positively affect the course of illness in schizophrenic women. In addition, low levels of estrogen might have a negative effect on bone mineral density and on the cardiovascular system.


METHODS
To test the "hypoestrogenism hypothesis", hormone levels in 75 women with schizophrenia diagnosed according to DSM-IV and ICD-10 were determined in the follicular, periovulatory, and luteal phases of the menstrual cycle. Levels of estradiol, prolactin, luteinizing hormone (LH), follicle-stimulating hormone (FSH), progesterone, and testosterone were assessed.


RESULTS
The serum levels of estradiol were generally reduced during the entire menstrual cycle compared to normal reference values. With low levels of LH over the entire cycle and of progesterone in the luteal phase, anovulatory cycles were assumed. Hypoestrogenism was found in about 60% of the patients in accordance with a strict definition (estradiol serum level below 30 pg/ml in the follicular phase and below 100 pg/ml in the periovulatory phase). To rule out a possible effect of hyperprolactinemia on the gonadal axis and a subsequent effect on estradiol levels from treatment with conventional ("typical") antipsychotics, serum estradiol levels of patients treated with certain atypical antipsychotics known to induce only a mild increase in prolactin, or no increase at all, were compared with those from patients treated with conventional antipsychotics. The data clearly indicate high prolactin levels in the latter, but low levels in the group treated with atypical antipsychotics. In both groups, however, low levels of estradiol compared to normal reference values were measured.


CONCLUSIONS
The present findings provide evidence that hypoestrogenism in schizophrenia occurs in women with and without antipsychotic-induced hyperprolactinemia. Further research should be conducted to clarify the cause of hypoestrogenism in schizophrenic women and focus on possible clinical implications.
Security and privacy issues in cloud computing

This paper shows a quick review of cloud computing technology along with its deployment and service models. We have focused in the security issues of cloud computing and we have listed most of the solutions which are available to solve these issues. Moreover, we have listed the most popular threats which been recognized by cloud security alliance (CSA). Also there are some other threats has been mentioned in this paper. Finally the privacy issues has been explained.
Altering source or amount of dietary carbohydrate has acute and chronic effects on postprandial glucose and triglycerides in type 2 diabetes: Canadian trial of Carbohydrates in Diabetes (CCD).

BACKGROUND AND AIMS
Nutrition recommendations for type 2 diabetes (T2DM) are partly guided by the postprandial responses elicited by diets varying in carbohydrate (CHO). We aimed to explore whether long-term changes in postprandial responses on low-glycemic-index (GI) or low-CHO diets were due to acute or chronic effects in T2DM.


METHODS AND RESULTS
Subjects with diet-alone-treated T2DM were randomly assigned to high-CHO/high-GI (H), high-CHO/low-GI (L), or low-CHO/high-monounsaturated-fat (M) diets for 12-months. At week-0 (Baseline) postprandial responses after H-meals (55% CHO, GI = 61) were measured from 0800 h to 1600 h. After 12 mo subjects were randomly assigned to H-meals or study diet meals (L, 57% CHO, GI = 50; M, 44% CHO, GI = 61). This yielded 5 groups: H diet with H-meals (HH, n = 34); L diet with H- (LH, n = 17) or L-meals (LL, n = 16); and M diet with H- (MH, n = 18) or M meals (MM, n = 19). Postprandial glucose fluctuations were lower in LL than all other groups (p < 0.001). Changes in postprandial-triglycerides differed among groups (p < 0.001). After 12 mo in HH and MM both fasting- and postprandial-triglycerides were similar to Baseline while in MH postprandial-triglycerides were significantly higher than at Baseline (p = 0.028). In LH, triglycerides were consistently (0.18-0.34 mmol/L) higher than Baseline throughout the day, while in LL the difference from Baseline varied across the day from 0.04 to 0.36 mmol/L (p < 0.001).


CONCLUSION
Low-GI and low-CHO diets have both acute and chronic effects on postprandial glucose and triglycerides in T2DM subjects. Thus, the composition of the acute test-meal and the habitual diet should be considered when interpreting the nutritional implications of different postprandial responses.
Fuzzy Fingerprint Vault

Biometrics-based authentication has the potential to eliminate illegal key exchange problem associated with traditional cryptosystems. In this paper, we explore the utilization of a fingerprint minutiae line based representation scheme in a new cryptographic construct called fuzzy vault. Minutiae variability is quantified for a fingerprint database marked by a human expert.