LLukas22/scidocs huggingface dataset:
Eculizumab for dense deposit disease and C3 glomerulonephritis.

BACKGROUND AND OBJECTIVES
The principle defect in dense deposit disease and C3 glomerulonephritis is hyperactivity of the alternative complement pathway. Eculizumab, a monoclonal antibody that binds to C5 to prevent formation of the membrane attack complex, may prove beneficial.


DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS
In this open-label, proof of concept efficacy and safety study, six subjects with dense deposit disease or C3 glomerulonephritis were treated with eculizumab every other week for 1 year. All had proteinuria >1 g/d and/or AKI at enrollment. Subjects underwent biopsy before enrollment and repeat biopsy at the 1-year mark.


RESULTS
The subjects included three patients with dense deposit disease (including one patient with recurrent dense deposit disease in allograft) and three patients with C3 glomerulonephritis (including two patients with recurrent C3 glomerulonephritis in allograft). Genetic and complement function testing revealed a mutation in CFH and MCP in one subject each, C3 nephritic factor in three subjects, and elevated levels of serum membrane attack complex in three subjects. After 12 months, two subjects showed significantly reduced serum creatinine, one subject achieved marked reduction in proteinuria, and one subject had stable laboratory parameters but histopathologic improvements. Elevated serum membrane attack complex levels normalized on therapy and paralleled improvements in creatinine and proteinuria.


CONCLUSIONS
Clinical and histopathologic data suggest a response to eculizumab in some but not all subjects with dense deposit disease and C3 glomerulonephritis. Elevation of serum membrane attack complex before treatment may predict response. Additional research is needed to define the subgroup of dense deposit disease/C3 glomerulonephritis patients in whom eculizumab therapy can be considered.
Towards a design generation methodology

Inspired by the recent advances of deep learning and computer graphics techniques in generating sophisticated artistic styles and architectural designs, we envision a general design generation methodology that uses various specification and generative methods and tools in an integral design cycle.
Operating room planning and scheduling: A literature review

This paper provides a review of recent research on operating room planning and scheduling. We evaluate the literature on multiple fields that are related to either the problem setting (e.g. performance measures or patient classes) or the technical features (e.g. solution technique or uncertainty incorporation). Since papers are pooled and evaluated in various ways, a diversified and detailed overview is obtained that facilitates the identification of manuscripts related to the reader’s specific interests. Throughout the literature review, we summarize the significant trends in research on operating room planning and scheduling and we identify areas that need to be addressed in the future.
Fuzzy Cognitive Network Process: Comparisons With Fuzzy Analytic Hierarchy Process in New Product Development Strategy

Fuzzy analytic hierarchy process (F-AHP) has increasingly been applied in many areas. However, as the perception and cognition toward the semantic representation for the linguistic rating scale used by the fuzzy pairwise comparison in F-AHP are still open to discuss, F-AHP very likely produces misapplications. This research proposes the fuzzy cognitive network process (F-CNP) as an ideal alternative to F-AHP. A new product development application using F-AHP is revised using F-CNP. This study shows that the proposed F-CNP yields better results due to the appropriate mathematical definition of the fuzzy paired interval scale for the human perception of paired difference.
Lucid dreaming treatment for nightmares: a pilot study.

BACKGROUND
The goal of this pilot study was to evaluate the effects of the cognitive-restructuring technique 'lucid dreaming treatment' (LDT) on chronic nightmares. Becoming lucid (realizing that one is dreaming) during a nightmare allows one to alter the nightmare storyline during the nightmare itself.


METHODS
After having filled out a sleep and a posttraumatic stress disorder questionnaire, 23 nightmare sufferers were randomly divided into 3 groups; 8 participants received one 2-hour individual LDT session, 8 participants received one 2-hour group LDT session, and 7 participants were placed on the waiting list. LDT consisted of exposure, mastery, and lucidity exercises. Participants filled out the same questionnaires 12 weeks after the intervention (follow-up).


RESULTS
At follow-up the nightmare frequency of both treatment groups had decreased. There were no significant changes in sleep quality and posttraumatic stress disorder symptom severity. Lucidity was not necessary for a reduction in nightmare frequency.


CONCLUSIONS
LDT seems effective in reducing nightmare frequency, although the primary therapeutic component (i.e. exposure, mastery, or lucidity) remains unclear.
Trolls just want to have fun

In two online studies (total N = 1215), respondents completed personality inventories and a survey of their Internet commenting styles. Overall, strong positive associations emerged among online commenting frequency, trolling enjoyment, and troll identity, pointing to a common construct underlying the measures. Both studies revealed similar patterns of relations between trolling and the Dark Tetrad of personality: trolling correlated positively with sadism, psychopathy, and Machiavellianism, using both enjoyment ratings and identity scores. Of all personality measures, sadism showed the most robust associations with trolling and, importantly, the relationship was specific to trolling behavior. Enjoyment of other online activities, such as chatting and debating, was unrelated to sadism. Thus cyber-trolling appears to be an Internet manifestation of everyday sadism. 2014 Elsevier Ltd. All rights reserved.
Data processing of high-rate low-voltage distribution grid recordings for smart grid monitoring and analysis

Power networks will change from a rigid hierarchic architecture to dynamic interconnected smart grids. In traditional power grids, the frequency is the controlled quantity to maintain supply and load power balance. Thereby, high rotating mass inertia ensures for stability. In the future, system stability will have to rely more on real-time measurements and sophisticated control, especially when integrating fluctuating renewable power sources or high-load consumers like electrical vehicles to the low-voltage distribution grid. In the present contribution, we describe a data processing network for the in-house developed low-voltage, high-rate measurement devices called electrical data recorder (EDR). These capture units are capable of sending the full high-rate acquisition data for permanent storage in a large-scale database. The EDR network is specifically designed to serve for reliable and secured transport of large data, live performance monitoring, and deep data mining. We integrate dedicated different interfaces for statistical evaluation, big data queries, comparative analysis, and data integrity tests in order to provide a wide range of useful post-processing methods for smart grid analysis. We implemented the developed EDR network architecture for high-rate measurement data processing and management at different locations in the power grid of our Institute. The system runs stable and successfully collects data since several years. The results of the implemented evaluation functionalities show the feasibility of the implemented methods for signal processing, in view of enhanced smart grid operation.
Face Recognition-A Tool for Automated Attendance System

Student attendance in a classroom is a time consuming task when done manually. Face recognition is a biometric powerful tool to authenticate a person. The other biometric attendance methods waste time as the students have to make a queue to touch their thumb on the scanning device. So, automated attendance system using face recognition is the efficient one for student attendance. Image acquisition, face detection and face recognition are the three parts of this system. The issue of fake attendance and proxies can be solved by using this system. This paper gives an overview of some known methods used to implement this system and also the benefits and drawbacks of it. This paper also proposes an efficient method by which we can implement such a system with high accuracy. Keywords— Student attendance, biometric, automated attendance system, face detection, face recognition
Plasma choline depletion is associated with decreased peripheral blood leukocyte acetylcholine in children with cystic fibrosis.

BACKGROUND
Choline is an important constituent of acetylcholine. Choline is needed for acetylcholine in the nonneuronal acetylcholine system that includes epithelial cells of the lung and intestine, endothelial cells, and immune cells. Plasma free choline concentrations are low in children with cystic fibrosis (CF), but the implications for acetylcholine are unknown.


OBJECTIVE
We determined the relation between plasma free choline and related metabolites and leukocyte acetylcholine in children with CF and in a control group of healthy children without CF.


DESIGN
This was a cross-sectional study in 34 children with CF who were pancreatic insufficient and taking pancreatic enzyme-replacement therapy and in 16 healthy children. Plasma free choline, betaine, dimethylglycine, methionine, homocysteine, and leukocyte acetylcholine concentrations were quantified by using isotope-dilution HPLC-tandem mass spectrometry.


RESULTS
Mean (±SE) plasma free choline was 9.30 ± 0.37 and 6.54 ± 0.38 μmol/L (P < 0.05) and leukocyte acetylcholine was 1.21 ± 0.016 and 0.077 ± 0.011 pmol leukocyte acetylcholine/10(6) cells (P < 0.05) in control children and children with CF, respectively. Leukocyte acetylcholine was positively correlated with plasma free choline concentration in children with CF (r = 0.412, P < 0.05) but not in control children. Plasma betaine, dimethylglycine, and methionine concentrations were also lower in children with CF than in control children (P < 0.05).


CONCLUSIONS
A low free choline and methyl status in children with CF is associated with reduced acetylcholine in leukocytes. Whether these changes are explained by a mutation in the CF transmembrane conductance regulator or disturbances in choline metabolism and the implications for immune cell dysfunction in CF are unknown. This trial was registered at clinicaltrials.gov as NCT01150136.
Boosting Neural Networks

Boosting is a general method for improving the performance of learning algorithms. A recently proposed boosting algorithm, Ada Boost, has been applied with great success to several benchmark machine learning problems using mainly decision trees as base classifiers. In this article we investigate whether Ada Boost also works as well with neural networks, and we discuss the advantages and drawbacks of different versions of the Ada Boost algorithm. In particular, we compare training methods based on sampling the training set and weighting the cost function. The results suggest that random resampling of the training data is not the main explanation of the success of the improvements brought by Ada Boost. This is in contrast to bagging, which directly aims at reducing variance and for which random resampling is essential to obtain the reduction in generalization error. Our system achieves about 1.4 error on a data set of on-line handwritten digits from more than 200 writers. A boosted multilayer network achieved 1.5 error on the UCI letters and 8.1 error on the UCI satellite data set, which is significantly better than boosted decision trees.
Perceived security, privacy, and trust concerns within Social Networking Sites: The role of Information sharing and relationships development in the Malaysian Higher Education Institutions' marketing

Nowadays, higher education is facing big challenges that made a lot of Higher Education Institutions (HEIs) become increasingly interested in attracting more students. Social Networking Sites (SNSs) such as Facebook have experienced exponential growth in recent years. These SNSs offer attractive means of online social interactions and communications, but also raise privacy security, and trust concerns. This study identified the effect of security, privacy, and trust in SNSs in order to share information and develop new relationships, which will affect students' enrollment and employees' application in HEIs. From the survey of 66 participants, the findings suggested that perceived privacy and perceived trust in other members in SNSs is significantly related with the Information sharing. Also, members' trust in SNSs and its members positively associated with development of new relationships, which is positively associated with students' enrollment and employees' application in HEIs. However, there is no significant impact from information sharing to develop new relationships in SNSs.
Estudo de avaliação da efi cácia do ácido tranexâmico tópico e injetável no tratamento do melasma Study evaluating the effi cacy of topical and injected tranexamic acid in treatment of melasma

Introduction: Melasma is an acquired hypermelanosis of multifactorial etiology. It is a great therapeutic chalenge. Tranexamic acid (TA) has been reported as an alternative therapy. Objective: To evaluate the effi cacy and safety of TA in treatment of melasma, comparing the use of localized microinjection versus topical therapy. Method: Eighteen women with melasma were selected and divided into 2 groups. Group A: At-home topical application of TA 3% twice a day. Group B: 12 applications of intradermal injections of TA (4 mg/ml) weekly. Before and after treatment, the groups were compared according to the following parameters: photographic evolution, Melasma Area and Severity Index (MASI) evolution, self-assessment and colorimetry. Results: Seventeen patients completed the study. In group A, photographic evaluation showed improvement in 12,5%, worsening in 50%, and 37.5% had no change. In group B, there was improvement in 66.7% and 22.2% had no change. For the MASI, there was signifi cant improvement (p = 0.0026), with no difference between treatments (p = 0.6512). In group A self-assessment, 37.5% of the patients rated as good and 50% as imperceptible. In group B, 66.7% rated as good and 33.3% as imperceptible. Colorimetric evaluation showed signifi cant improvement on both treatments (p = 0.0008). Conclusion: Although the subjective clinical evaluation has demonstrated the superiority of injected treatment, in objective evaluation, both treatments were signifi cantly effective, presenting TA as a promising new therapeutic option for melasma.
APC Haploinsufficiency, but Not CTNNB1 or CDH1 Gene Mutations, Accounts for a Fraction of Familial Adenomatous Polyposis Patients Without APC Truncating Mutations

Familial adenomatous polyposis (FAP) is an autosomal dominant condition characterized by the development of hundreds to thousands of colorectal adenomatous polyps. In addition to the classic form, there is also attenuated polyposis (attenuated adenomatous polyposis coli; AAPC), which is characterized by a milder phenotype. FAP/AAPC is caused by germline mutations in the adenomatous polyposis coli (APC) gene. Very recently, germline mutations in the base-excision repair gene MYH have been associated with recessive inheritance of multiple colorectal adenomas in a subset of patients. APC pathogenic alterations are mostly (>95%) represented by frameshift or nonsense mutations leading to the synthesis of a truncated protein. We identified 20 APC truncating mutation carriers out of 30 FAP/AAPC patients from different Italian kindreds. In the remaining 10 patients, we searched for alterations other than truncating mutations by enzymatic mutation detection, real-time quantitative RT-PCR, and genotyping of polymorphic markers encompassing the APC locus. Moreover, to assess whether mutations of genes interacting with APC can substitute or act in association with APC alterations, we sequenced both CTNNB1 (β-catenin) and CDH1 (E-cadherin) genes. No CTNNB1 or CDH1 mutations were found. On the contrary, four patients showed a reduced APC gene expression compared with healthy subjects. In three of the four cases, genotyping results were compatible with a constitutive allelic deletion. In one case this conclusion was confirmed by haplotype segregation analysis. Our results support the notion that FAP/AAPC can result from APC constitutive haploinsufficiency, with gene deletion being a possible cause of reduced gene expression.
High-impact environmental research

ES&T looks at the people, events, and issues that led to the publication of 10 highly cited papers.
Motor Development and Physical Activity: A Longitudinal Discordant Twin-Pair Study.

INTRODUCTION
Previous longitudinal research suggests that motor proficiency in early life predicts physical activity in adulthood. Familial effects including genetic and environmental factors could explain the association, but no long-term follow-up studies have taken into account potential confounding by genetic and social family background. The present twin study investigated whether childhood motor skill development is associated with leisure-time physical activity levels in adulthood independent of family background.


METHODS
Altogether, 1550 twin pairs from the FinnTwin12 study and 1752 twin pairs from the FinnTwin16 study were included in the analysis. Childhood motor development was assessed by the parents' report of whether one of the co-twins had been ahead of the other in different indicators of motor skill development in childhood. Leisure-time physical activity (MET·h·d) was self-reported by the twins in young adulthood and adulthood. Statistical analyses included conditional and ordinary linear regression models within twin pairs.


RESULTS
Using all activity-discordant twin pairs, the within-pair difference in a sum score of motor development in childhood predicted the within-pair difference in the leisure-time physical activity level in young adulthood (P < 0.001). Within specific motor development indicators, learning to stand unaided earlier in infancy predicted higher leisure-time MET values in young adulthood statistically significantly in both samples (FinnTwin12, P = 0.02; and FinnTwin16, P = 0.001) and also in the pooled data set of the FinnTwin12 and FinnTwin16 studies (P < 0.001). Having been more agile than the co-twin as a child predicted higher leisure-time MET values up to adulthood (P = 0.03).


CONCLUSIONS
More advanced childhood motor development is associated with higher leisure-time MET values in young adulthood at least partly independent of family background in both men and women.
Industrial-Organizational Psychology and Organizational Behavior Management : An Objective Comparison

This article compares traditional industrial-organizational psychology (I-O) research published in Journal of Applied Psychology (JAP) with organizational behavior management (OBM) research published in Journal of Organizational Behavior Management (JOBM). The purpose of this comparison was to identify similarities and differences with respect to research topics and methodologies, and to offer suggestions for what OBM researchers and practitioners can learn from I-O. Articles published in JAP from 1987-1997 were reviewed and compared to articles published during the same decade in JOBM (Nolan, Jarema, & Austin, 1999). This comparison includes Barbara R. Bucklin, Alicia M. Alvero, Alyce M. Dickinson, John Austin, and Austin K. Jackson are affiliated with Western Michigan University. Address correspondence to Alyce M. Dickinson, Department of Psychology, Western Michigan University, Kalamazoo, MI 49008-5052 (E-mail: alyce.dickinson@ wmich.edu.) Journal of Organizational Behavior Management, Vol. 20(2) 2000 E 2000 by The Haworth Press, Inc. All rights reserved. 27 D ow nl oa de d by [ W es te rn M ic hi ga n U ni ve rs ity ] at 1 1: 14 0 3 Se pt em be r 20 12 JOURNAL OF ORGANIZATIONAL BEHAVIOR MANAGEMENT 28 (a) author characteristics, (b) authors published in both journals, (c) topics addressed, (d) type of article, and (e) research characteristics and methodologies. Among the conclusions are: (a) the primary relative strength of OBM is its practical significance, demonstrated by the proportion of research addressing applied issues; (b) the greatest strength of traditional I-O appears to be the variety and complexity of organizational research topics; and (c) each field could benefit from contact with research published in the other. [Article copies available for a fee from The Haworth Document Delivery Service: 1-800-342-9678. E-mail address: <getinfo@haworthpressinc.com> Website: <http://www.HaworthPress.com>]
A predictive model to identify hospitalized cancer patients at risk for 30-day mortality based on admission criteria via the electronic medical record.

BACKGROUND
This study sought to develop a predictive model for 30-day mortality in hospitalized cancer patients, by using admission information available through the electronic medical record.


METHODS
Observational cohort study of 3062 patients admitted to the oncology service from August 1, 2008, to July 31, 2009. Matched numbers of patients were in the derivation and validation cohorts (1531 patients). Data were obtained on day 1 of admission and included demographic information, vital signs, and laboratory data. Survival data were obtained from the Social Security Death Index.


RESULTS
The 30-day mortality rate of the derivation and validation samples were 9.5% and 9.7% respectively. Significant predictive variables in the multivariate analysis included age (P < .0001), assistance with activities of daily living (ADLs; P = .022), admission type (elective/emergency) (P = .059), oxygen use (P < .0001), and vital signs abnormalities including pulse oximetry (P = .0004), temperature (P = .017), and heart rate (P = .0002). A logistic regression model was developed to predict death within 30 days: Score = 18.2897 + 0.6013*(admit type) + 0.4518*(ADL) + 0.0325*(admit age) - 0.1458*(temperature) + 0.019*(heart rate) - 0.0983*(pulse oximetry) - 0.0123 (systolic blood pressure) + 0.8615*(O2 use). The largest sum of sensitivity (63%) and specificity (78%) was at -2.09 (area under the curve = -0.789). A total of 25.32% (100 of 395) of patients with a score above -2.09 died, whereas 4.31% (49 of 1136) of patients below -2.09 died. Sensitivity and positive predictive value in the derivation and validation samples compared favorably.


CONCLUSIONS
Clinical factors available via the electronic medical record within 24 hours of hospital admission can be used to identify cancer patients at risk for 30-day mortality. These patients would benefit from discussion of preferences for care at the end of life.