LLukas22/scidocs huggingface dataset:
Development of a practical costing method for hospitals.

To realize an effective cost control, a practical and accurate cost accounting system is indispensable in hospitals. In traditional cost accounting systems, the volume-based costing (VBC) is the most popular cost accounting method. In this method, the indirect costs are allocated to each cost object (services or units of a hospital) using a single indicator named a cost driver (e.g., Labor hours, revenues or the number of patients). However, this method often results in rough and inaccurate results. The activity based costing (ABC) method introduced in the mid 1990s can prove more accurate results. With the ABC method, all events or transactions that cause costs are recognized as "activities", and a specific cost driver is prepared for each activity. Finally, the costs of activities are allocated to cost objects by the corresponding cost driver. However, it is much more complex and costly than other traditional cost accounting methods because the data collection for cost drivers is not always easy. In this study, we developed a simplified ABC (S-ABC) costing method to reduce the workload of ABC costing by reducing the number of cost drivers used in the ABC method. Using the S-ABC method, we estimated the cost of the laboratory tests, and as a result, similarly accurate results were obtained with the ABC method (largest difference was 2.64%). Simultaneously, this new method reduces the seven cost drivers used in the ABC method to four. Moreover, we performed an evaluation using other sample data from physiological laboratory department to certify the effectiveness of this new method. In conclusion, the S-ABC method provides two advantages in comparison to the VBC and ABC methods: (1) it can obtain accurate results, and (2) it is simpler to perform. Once we reduce the number of cost drivers by applying the proposed S-ABC method to the data for the ABC method, we can easily perform the cost accounting using few cost drivers after the second round of costing.
A DC to 22GHz, 2W high power distributed amplifier using stacked FET topology with gate periphery tapering

This paper describes a high power (2W) distributed amplifier (DA) MMIC. DA MMIC was fabricated using an Lg=0.25μm GaAs PHEMT process. DA MMIC contains an impedance transformer and heavily tapered gate periphery design for constant output power performance over 0.1 to 22GHz operational frequency. To obtain high voltage operation, the DA MMIC employed a three stacked FET topology. A 7-section DA demonstrated 2 W saturated output power and 12 dB small signal gain from 0.1 GHz to 22 GHz with peak output power of 3.5 W with power added efficiency (PAE) of 27%. Those test results exceeded recently reported GaN based power DA performance [4] with large margins.
Why You Should Run TPC-DS: A Workload Analysis

The Transaction Processing Performance Council (TPC) is completing development of TPC-DS, a new generation industry standard decision support benchmark. The TPC-DS benchmark, first introduced in the “The Making of TPC-DS” [9] paper at the 32 International Conference on Very Large Data Bases (VLDB), has now entered the TPC’s “Formal Review” phase for new benchmarks; companies and researchers alike can now download the draft benchmark specification and tools for evaluation. The first paper [9] gave an overview of the TPC-DS data model, workload model, and execution rules. This paper details the characteristics of different phases of the workload, namely: database load, query workload and data maintenance; and also their impact to the benchmark’s performance metric. As with prior TPC benchmarks, this workload will be widely used by vendors to demonstrate their capabilities to support complex decision support systems, by customers as a key factor in purchasing servers and software, and by the database community for research and development of optimization techniques.
Conflict coverage and conflict escalation

Though still existent traditional state propaganda as characteristic during the World Wars (see Lasswell, 1927; Knightly, 1975; and chapters 2 and 4 of this volume) has been partly delegated to professional PR agencies in recent conflicts (Kunczik, 1990). During both the Gulf War (MacAlthur, 1992) and the Bosnia conflict (Beham. 1996), the role of PR agencies became so massive, and filters used to sort out virtual PR reality from real facts so few, that it became extremely difficult to assess the situation without knowing what the PR firms had transmitted. But this was only a first step in what may be called the privatization of propaganda (Luostarinen & Kempf, 2(00). During the Bosnia conflict, journalists themselves deliberately threw away professional rules and standards of truth in the name of a moral enterprise 'that is aware of its responsibilities; and will not stand neutrally between good and evil, right and wrong, the victim and the oppressor' (Bell, 1997). As one of the results of the post-Cold War military conflicts, journalists have become aware that the media do not just report about war and peace, but they play an active part in the game. As a reaction to this insight, a new school of war reporting is taking over the media world, which BBC correspondent Martin Bell (1997) calls the Journalism of Attachment. This Journalism of Attachment says that reporters cannot remain detached or neutral in the face of modern evils like genocide in Bosnia, but that journalists have to take side with the victims and demand that something must be done. So far, the Journalism of Attachment sounds like a worthy appeal for concerned reporting and seems to share the same values as Peace Journalism. But the problem with Journalism of Attachment is that it has no vision of constructive conflict transformation and no analysis of the political and social roots of wars. Journalism of Attachment depicts war as an exclUSively moral struggle in which Right fights Wrong. As journalists appoint themselves judges of who is good or evil in the world, and as they place moral pressure on the international community to take sides, the Journalism of Attachment replaces the rules of journalism with the rules of propaganda. The coverage of the Bosnia and Kosovo conWcts is full of examples of how journalists served their moral impetus by means of information control and fabrication of news (see chapter 13 below),
Preliminary experience with the LionHeart left ventricular assist device in patients with end-stage heart failure.

BACKGROUND
The Arrow LionHeart LVD 2000 left ventricular assist device is the first fully implantable system designed for destination therapy. We report on 2 years of experience with this device, which we implanted for the first time in October 1999.


METHODS
Since October 1999, 6 male patients between 55 and 69 years of age (mean 65 +/- 6 years) have received the device at our center; all were in New York Heart Association functional class IV and ineligible for heart transplantation.


RESULTS
All surgical procedures were uneventful, with a timely extubation in 5 of 6 patients. Duration of support was 17 to 670 (mean 245 +/- 138) days, with a cumulative experience of 4.5 years. Three patients recovered to be discharged from hospital under support and are long-term survivors. Three patients died 17, 31, and 112 days after implantation from multiple organ failure without being discharged to their homes. The survival rate is 50% after 18 months. There were no major system-related problems or any device-related infections, which are otherwise commonly found among vertricular assist device patients.


CONCLUSIONS
Our preliminary experience demonstrates the reliability and efficacy of the different parts of the system. Nevertheless, further sophistication is needed to reduce the size of its components, which so far still constitutes a limiting factor.
Group skyline computation

Given a multi-dimensional dataset of tuples, skyline computation returns a subset of tuples that are not dominated by any other tuples when all dimensions are considered together. Conventional skyline computation, however, is inadequate to answer various queries that need to analyze not just individual tuples of a dataset but also their combinations. In this paper, we study group skyline computation which is based on the notion of dominance relation between groups of the same number of tuples. It determines the dominance relation between two groups by comparing their aggregate values such as sums or averages of elements of individual dimensions, and identifies a set of skyline groups that are not dominated by any other groups. We investigate properties of group skyline computation and develop a group skyline algorithm GDynamic which is equivalent to a dynamic algorithm that fills a table of skyline groups. Experimental results show that GDynamic is a practical group skyline algorithm. 2011 Elsevier Inc. All rights reserved.
A cluster randomized trial to evaluate the efficacy of a school-based behavioral intervention for health promotion among children aged 3 to 5

BACKGROUND
The onset of inadequate behaviors leading to the development of risk factors for chronic diseases is known to occur early in life. An effective program for health promotion should therefore focus on children and their environment, as the starting point for behavior development. The overarching objective of the Program SI! (Salud Integral - Comprehensive Health) is to intervene at the school level, to establish and develop life-lasting habits that will help preserving health during adulthood. The Program SI! comprises five consecutive subprograms according to the five stages of education in Spain, the first being in preschoolers. This study aims to evaluate the efficacy of Program SI! to establish and improve lifestyle behaviors in children (preschoolers aged 3-5 years), their parents, and teachers, and also improving the school environment. A secondary objective is to evaluate improvements in cardiovascular health-related markers (anthropometric parameters, blood pressure, and dietary and physical activity patterns) in these same children.


METHODS/DESIGN
24 public schools from the city of Madrid (Spain) were allocated through stratified randomization to intervention or control. The intervention schools follow the Program SI!, which provides didactic units, emotions cards, healthy tips, and online resources. The intervention schools integrate the Program SI! into their scholar curriculum organized in four complete weeks during each academic year during the 3 years of preschool education. Control schools follow their normal curriculum. Primary outcomes are 1-year, and 3-year changes from baseline of scores for knowledge, attitudes, and habits (KAH) of children, their parents and teachers in regards to a healthy lifestyle. Secondary outcomes are 1-year, and 3-year changes from baseline in clinical and anthropometric parameters of children.


DISCUSSION
The Program SI! is a long-term health promotion program starting in 3 years old. It incorporates the traditional areas of intervention (diet and physical activity), introducing additional components such as knowledge of the human body and management of emotions to achieve a comprehensive intervention. The Program SI! is designed to be an effective, sustainable health promotion program for the adoption of healthy behaviors from early in life.


TRIAL REGISTRATION



TRIAL REGISTRATION NUMBER
NCT01579708.
Associations of ECP (eosinophil cationic protein)-gene polymorphisms to allergy, asthma, smoke habits and lung function in two Estonian and Swedish sub cohorts of the ECRHS II study

BACKGROUND
The Eosinophil Cationic Protein (ECP) is a potent multifunctional protein. Three common polymorphisms are present in the ECP gene, which determine the function and production of the protein. The aim was to study the relationship of these ECP gene polymorphisms to signs and symptoms of allergy and asthma in a community based cohort (The European Community Respiratory Health Survey (ECRHS)).


METHODS
Swedish and Estonian subjects (n = 757) were selected from the larger cohort of the ECRHS II study cohort. The prevalence of the gene polymorphisms ECP434(G>C) (rs2073342), ECP562(G>C) (rs2233860) and ECP c.-38(A>C) (rs2233859) were analysed by DNA sequencing and/or real-time PCR and related to questionnaire-based information of allergy, asthma, smoking habits and to lung functions.


RESULTS
Genotype prevalence showed both ethnic and gender differences. Close associations were found between the ECP434(G>C) and ECP562(G>C) genotypes and smoking habits, lung function and expression of allergic symptoms. Non-allergic asthma was associated with an increased prevalence of the ECP434GG genotype. The ECP c.-38(A>C) genotypes were independently associated to the subject being atopic.


CONCLUSION
Our results show associations of symptoms of allergy and asthma to ECP-genotypes, but also to smoking habits. ECP may be involved in impairment of lung functions in disease. Gender, ethnicity and smoking habits are major confounders in the evaluations of genetic associations to allergy and asthma.
The miRNA Profile of Human Pancreatic Islets and Beta-Cells and Relationship to Type 2 Diabetes Pathogenesis

Recent advances in the understanding of the genetics of type 2 diabetes (T2D) susceptibility have focused attention on the regulation of transcriptional activity within the pancreatic beta-cell. MicroRNAs (miRNAs) represent an important component of regulatory control, and have proven roles in the development of human disease and control of glucose homeostasis. We set out to establish the miRNA profile of human pancreatic islets and of enriched beta-cell populations, and to explore their potential involvement in T2D susceptibility. We used Illumina small RNA sequencing to profile the miRNA fraction in three preparations each of primary human islets and of enriched beta-cells generated by fluorescence-activated cell sorting. In total, 366 miRNAs were found to be expressed (i.e. >100 cumulative reads) in islets and 346 in beta-cells; of the total of 384 unique miRNAs, 328 were shared. A comparison of the islet-cell miRNA profile with those of 15 other human tissues identified 40 miRNAs predominantly expressed (i.e. >50% of all reads seen across the tissues) in islets. Several highly-expressed islet miRNAs, such as miR-375, have established roles in the regulation of islet function, but others (e.g. miR-27b-3p, miR-192-5p) have not previously been described in the context of islet biology. As a first step towards exploring the role of islet-expressed miRNAs and their predicted mRNA targets in T2D pathogenesis, we looked at published T2D association signals across these sites. We found evidence that predicted mRNA targets of islet-expressed miRNAs were globally enriched for signals of T2D association (p-values <0.01, q-values <0.1). At six loci with genome-wide evidence for T2D association (AP3S2, KCNK16, NOTCH2, SCL30A8, VPS26A, and WFS1) predicted mRNA target sites for islet-expressed miRNAs overlapped potentially causal variants. In conclusion, we have described the miRNA profile of human islets and beta-cells and provide evidence linking islet miRNAs to T2D pathogenesis.
Frequency and pattern of de-novo three-vessel and left main coronary artery disease; insights from single center enrolment in the SYNTAX study.

OBJECTIVES
To characterize the current patient population regarding extent and pattern of coronary artery disease (CAD) in a routine cardiac catheterization practice with special focus on de-novo three-vessel coronary artery and/or left main disease (3-VD/LM) during enrolment in the SYNTAX study (synergy between PCI with Taxus drug-eluting stent and cardiac surgery) comparing percutaneous coronary intervention (PCI) with drug-eluting stents (DES) and coronary artery bypass grafting (CABG) in 3-VD/LM.


METHODS
During a 4-month study enrolment period, a total of 3319 consecutive adult patients undergoing coronary angiography were prospectively recorded. Patients with de-novo 3-VD/LM were screened in the daily heart team conference by interventional cardiologists and cardiac surgeons concerning suitability for study enrolment. Complexity of CAD was quantified by the SYNTAX score.


RESULTS
A total of 694 patients (20.9%) presented with 3-VD/LM, of which 271 had previous CABG and 232 previous PCI treatment. Of the 191 patients with de-novo 3-VD/LM, SYNTAX study exclusion criteria were present in 87 patients consisting mostly of acute myocardial infarction (n=47) or concomitant indications for additional heart surgery (n=35). A total of 104 patients (54.4% of all screened) were potentially suitable for study enrolment. Of these, 13 patients refused study participation, 10 presented with uncertain protocol adherence and 6 were already participating in other cardiovascular trials. A total of 67 patients were therefore enrolled in the SYNTAX study, representing 9.7% of 3-VD/LM and 35.1% of all screened patients. Twenty-four patients were not amenable for PCI and were therefore assigned to the CABG registry. Compared to the randomized cohort, these patients had more complex CAD (SYNTAX score 34 vs 26, p=0.003) with significantly more chronic coronary vessel occlusion (70.8% vs 22.5%, p=0.04). In the randomized cohort, CABG and PCI patients were comparable in age (PCI 69.7 years vs CABG 67.2 years), additive EuroSCORE (4.8 vs 4.4), EF (57.8% vs 52.4%), number of coronary lesions (4.5 vs 4.6), left main disease (42.9% vs 52.6%) and coronary vessel occlusion.


CONCLUSIONS
Patients with de-novo 3-VD/LM represented a small proportion of patients undergoing coronary angiography at our center. However, SYNTAX study inclusion and randomization rates of these screened patients were high. Chronic vessel occlusion and high SYNTAX scores were more common in CABG registry patients compared to randomized patients.
Increased heart rate and reduced heart-rate variability are associated with subclinical inflammation in middle-aged and elderly subjects with no apparent heart disease.

AIM
Elevation of inflammation markers, high heart rate, and reduced heart-rate variability are all strong markers of mortality in a broad spectrum of patients. The association between these markers has not been clarified thoroughly. We investigated the associations between markers of inflammation, heart rate, and heart-rate variability.


METHODS AND RESULTS
Six hundred and forty-three healthy men and women between 55 and 75 years of age and with no prior history of cardiovascular disease or stroke were included in the study. The baseline study included a physical examination, fasting laboratory tests, and 24-h ambulatory ECG monitoring. We selected the time-domain components of heart-rate variability for further analyses. C-reactive protein concentration and white blood cell count were selected as markers of inflammation. After identifying parameters related to measures of heart-rate variability, we used regression analyses to evaluate independent associations. Heart-rate variability, as measured by the standard deviation of the time between normal-to-normal complexes or the standard deviation of the average of normal-to-normal intervals for each 5-min period, was negatively associated with smoking, C-reactive protein, white blood cell count, blood sugar and triglyceride concentration, female gender, and diabetes. In contrast, physical activity was strongly associated with higher heart-rate variability. In multivariate regression analyses, increased heart-rate and reduced heart-rate variability were significantly and independently related to white blood cell count or C-reactive protein concentration.


CONCLUSION
Increased heart rate and reduced heart-rate variability are associated with subclinical inflammation in healthy middle-aged and elderly subjects. The increased mortality that has been reported in these settings may thus have a common aetiology. An autonomic imbalance in favour of the sympathetic system may interact with inflammatory processes to play a more important role in the process of atherosclerosis than previously thought.
Development of Risk Score for Predicting 3-Year Incidence of Type 2 Diabetes: Japan Epidemiology Collaboration on Occupational Health Study

OBJECTIVE
Risk models and scores have been developed to predict incidence of type 2 diabetes in Western populations, but their performance may differ when applied to non-Western populations. We developed and validated a risk score for predicting 3-year incidence of type 2 diabetes in a Japanese population.


METHODS
Participants were 37,416 men and women, aged 30 or older, who received periodic health checkup in 2008-2009 in eight companies. Diabetes was defined as fasting plasma glucose (FPG) ≥ 126 mg/dl, random plasma glucose ≥ 200 mg/dl, glycated hemoglobin (HbA1c) ≥ 6.5%, or receiving medical treatment for diabetes. Risk scores on non-invasive and invasive models including FPG and HbA1c were developed using logistic regression in a derivation cohort and validated in the remaining cohort.


RESULTS
The area under the curve (AUC) for the non-invasive model including age, sex, body mass index, waist circumference, hypertension, and smoking status was 0.717 (95% CI, 0.703-0.731). In the invasive model in which both FPG and HbA1c were added to the non-invasive model, AUC was increased to 0.893 (95% CI, 0.883-0.902). When the risk scores were applied to the validation cohort, AUCs (95% CI) for the non-invasive and invasive model were 0.734 (0.715-0.753) and 0.882 (0.868-0.895), respectively. Participants with a non-invasive score of ≥ 15 and invasive score of ≥ 19 were projected to have >20% and >50% risk, respectively, of developing type 2 diabetes within 3 years.


CONCLUSIONS
The simple risk score of the non-invasive model might be useful for predicting incident type 2 diabetes, and its predictive performance may be markedly improved by incorporating FPG and HbA1c.
Resource-based theories of competitive advantage : A ten-year retrospective

The resource-based view can be positioned relative to at least three theoretical traditions: SCPbased theories of industry determinants of firm performance, neo-classical microeconomics, and evolutionary economics. In the 1991 article, only the first of these ways of positioning the resourcebased view is explored. This article briefly discusses some of the implications of positioning the resource-based view relative to these other two literatures; it also discusses some of the empirical implications of each of these different resource-based theories. © 2001 Elsevier Science Inc. All rights reserved.
New signatures and sources for the detection of WIMP dark matter in the solar system11Research supported in part by DOE.

Abstract I first outline new results on the angular modulation of WIMP dark matter scattering on targets in terrestrial laboratories, based on our uncertainties of the WIMP halo distribution, I then outline an exciting new result which indicates that for the high end of allowed SUSY WIMP scattering cross sections there exists a new distribution of WIMP dark matter in our solar system which could produce a dramatically different signal from halo WIMP dark matter in terrestrial detectors.
Generating a shoe last shape using Laplacian deformation

Body-shape data from 3D digitizers are utilized to design various products. We present the method generating a shoe last shape from 3D scanned foot data. To generate a producible last shape that fit to subject's foot, we apply designing method originated from a shoemaker to the foot shape. Then the constraints on last shape are derived. We deform a template surface with Laplacian deformation under the constraints. As a result of that, we try to obtain a custom last shape.