LLukas22/scidocs huggingface dataset:
QMC designs: Optimal order Quasi Monte Carlo integration schemes on the sphere

We study equal weight numerical integration, or Quasi Monte Carlo (QMC) rules, for functions in a Sobolev space Hs(Sd) with smoothness parameter s > d/2 defined over the unit sphere Sd in Rd+1. Focusing on N-point configurations that achieve optimal order QMC error bounds (as is the case for efficient spherical designs), we are led to introduce the concept of QMC designs: these are sequences of N-point configurations XN on S d such that the worst-case error satisfies sup f∈H(S), ‖f‖Hs≤1 ∣∣∣∣ 1 N ∑ x∈XN f(x)− ∫ Sd f(x) dσd(x) ∣∣∣∣ = O ( N−s/d ) , N → ∞, with an implied constant that depends on the Hs(Sd)-norm, but is independent of N . Here σd is the normalized surface measure on S d. We provide methods for generation and numerical testing of QMC designs. An essential tool is an expression for the worst-case error in terms of a reproducing kernel for the space Hs(Sd) with s > d/2. As a consequence of this and a recent result of Bondarenko et al. on the existence of spherical designs with appropriate number of points, we show that minimizers of the N-point energy for this kernel form a sequence of QMC designs for Hs(Sd). Furthermore, without appealing to the Bondarenko et al. result, we prove that point sets that maximize the sum of suitable powers of the Euclidean distance between pairs of points form a sequence of QMC designs for Hs(Sd) with s in the interval (d/2, d/2 + 1). For such spaces there exist reproducing kernels with simple closed forms that are useful for numerical testing of optimal order Quasi Monte Carlo integration. Numerical experiments suggest that many familiar sequences of point sets on the sphere (equal area points, spiral points, minimal [Coulomb or logarithmic] energy points, and Fekete points) are QMC designs for appropriate values of s. For comparison purposes we show that configurations of random points that are independently and uniformly distributed on the sphere do not constitute QMC designs for any s > d/2. If (XN ) is a sequence of QMC designs for H s(Sd), we prove that it is also a sequence of QMC designs for Hs ′ (Sd) for all s′ ∈ (d/2, s). This leads to the question of determining the supremum of such s (here called the QMC strength of the sequence), for which we provide estimates based on computations for the aforementioned sequences. Received by the editor August 15, 2012 and, in revised form, February 26, 2013. 2010 Mathematics Subject Classification. Primary 65D30, 65D32; Secondary 11K38, 41A55.
Simple, effective and safe vascular access site closure with the double-ProGlide preclose technique in 162 patients receiving transfemoral transcatheter aortic valve implantation.

OBJECTIVES
Aim of this study was to analyze feasibility, efficacy, and safety of a double-ProGlide preclose technique for access site closure after transfemoral transcatheter aortic valve implantation (TAVI).


BACKGROUND
An effective and safe transcutaneous closure device is advantageous in transfemoral TAVI to avoid surgical cut down of the large caliber sheath insertion site. The use of two ProGlide sutures has not been described in this context in a large patient cohort.


METHODS
ProGlide closure was used between 2010 and 2012 in 162 patients. ProGlide sutures were deployed in a preclose technique prior to insertion of the large caliber sheath. Success of the closure technique was defined as effective hemostasis and no further access site-related vascular or bleeding complications during the index hospitalization.


RESULTS
Patients were 82 ± 5 years old with a logistic EuroSCORE of 16.7 ± 12.5. Edwards SAPIEN valves were used in 81.5% and Medtronic CoreValves in 18.5%. The overall success rate of the double-ProGlide technique was 93.9%. Success rate was only 40.0% under circumstances of prolonged high-dose heparinization. Success rate was 96.8% among the patients on dual-antiplatelet therapy (DAPT). All 10 ProGlide failures could effectively be managed by either percutaneous angioplasty or surgical reconstruction. The rate of VARC major vascular complications was 4.3%. Thirty-day mortality was 5.6%.


CONCLUSION
The double-ProGlide preclose technique offers a simple, highly effective, and safe method for closure of the arterial access site after transfemoral TAVI. The double-ProGlide strategy results in low rates of major vascular complications and translates into favorable early outcome.
Functional connectivity classification of autism identifies highly predictive brain features but falls short of biomarker standards

OBJECTIVES
Autism spectrum disorders (ASD) are diagnosed based on early-manifesting clinical symptoms, including markedly impaired social communication. We assessed the viability of resting-state functional MRI (rs-fMRI) connectivity measures as diagnostic biomarkers for ASD and investigated which connectivity features are predictive of a diagnosis.


METHODS
Rs-fMRI scans from 59 high functioning males with ASD and 59 age- and IQ-matched typically developing (TD) males were used to build a series of machine learning classifiers. Classification features were obtained using 3 sets of brain regions. Another set of classifiers was built from participants' scores on behavioral metrics. An additional age and IQ-matched cohort of 178 individuals (89 ASD; 89 TD) from the Autism Brain Imaging Data Exchange (ABIDE) open-access dataset (http://fcon_1000.projects.nitrc.org/indi/abide/) were included for replication.


RESULTS
High classification accuracy was achieved through several rs-fMRI methods (peak accuracy 76.67%). However, classification via behavioral measures consistently surpassed rs-fMRI classifiers (peak accuracy 95.19%). The class probability estimates, P(ASD|fMRI data), from brain-based classifiers significantly correlated with scores on a measure of social functioning, the Social Responsiveness Scale (SRS), as did the most informative features from 2 of the 3 sets of brain-based features. The most informative connections predominantly originated from regions strongly associated with social functioning.


CONCLUSIONS
While individuals can be classified as having ASD with statistically significant accuracy from their rs-fMRI scans alone, this method falls short of biomarker standards. Classification methods provided further evidence that ASD functional connectivity is characterized by dysfunction of large-scale functional networks, particularly those involved in social information processing.
Effects of Gua-Sha therapy on breast engorgement: a randomized controlled trial.

BACKGROUND
Breast engorgement is a common problem that affects the initiation and duration of breastfeeding. Limited solutions are available to relieve the discomfort associated with breast engorgement. Thus, further investigation of methods to achieve effective relief of symptoms is critical to promote breastfeeding success.


PURPOSE
: The purpose of this study was to determine the effects of two breast care methods, that is, scraping (Gua-Sha) therapy (administered to the experimental group) and traditional breast care (i.e., massage and heating; administered to the control group).


METHODS
A randomized controlled trial was conducted on 54 postpartum women at a Level III medical teaching hospital. Participant inclusion criteria included postpartum breastfeeding women (a) who had an uncomplicated delivery and (b) who were experiencing breast engorgement problems. The Gua-Sha protocol selected appropriate acupoint positions, which included ST16, ST18, SP17, and CV17. Each position was lightly scraped seven times in two cycles. For the control group, we used hot packs and massage for 20 min in accordance with recommendations given in an obstetrical technique textbook.


RESULTS
Results showed no statistical differences between the two groups at baseline. Body temperature, breast temperature, breast engorgement, pain levels, and discomforting levels were statistically different between the two groups at 5 and 30 min after intervention (p < .001). The results of generalized estimating equation analysis indicated that, with the exception of body temperature, all variables remained more significant (p < .0001) to improving engorgement symptoms in the experimental group than those in the control group, after taking related variables into account.


CONCLUSIONS AND IMPLICATIONS FOR PRACTICE
Our findings provided empirical evidence supporting that Gua-Sha therapy may be used as an effective technique in the management of breast engorgement. By using Gua-Sha therapy, nurses can handle breast engorgement problems more effectively in primary care and hence help patients both physically and psychologically.
Life-cycle carbon and cost analysis of energy efficiency measures in new commercial buildings

Energy efficiency in new building construction has become a key target to lower nation-wide energy use. The goals of this paper are to estimate life-cycle energy savings, carbon emission reduction, and costeffectiveness of energy efficiency measures in new commercial buildings using an integrated design approach, and estimate the implications from a cost on energy-based carbon emissions. A total of 576 energy simulations are run for 12 prototypical buildings in 16 cities, with 3 building designs for each building-location combination. Simulated energy consumption and building cost databases are used to determine the life-cycle cost-effectiveness and carbon emissions of each design. The results show conventional energy efficiency technologies can be used to decrease energy use in new commercial buildings by 20–30% on average and up to over 40% for some building types and locations. These reductions can often be done at negative life-cycle costs because the improved efficiencies allow the installation of smaller, cheaper HVAC equipment. These improvements not only save money and energy, but reduce a building’s carbon footprint by 16% on average. A cost on carbon emissions from energy use increases the return on energy efficiency investments because energy is more expensive, making some cost-ineffective projects economically feasible. Published by Elsevier B.V. Abbreviations: AIRR, adjusted internal rate of return; ASHRAE, American Society of Heating, Refrigerating, and Air-Conditioning Engineers; BEES, building for environmental and economic sustainability; CBECS, commercial buildings energy consumption survey; EIA, U.S. Department of Energy’s Energy Information Administration; eGRID, U.S. Environmental Protection Agency’s 2007 Emissions and Generation Integrated Database; EPA, Environmental Protection Agency; HVAC, heating, ventilation, and air conditioning; LCC, life-cycle costing; LEC, low energy case; LEED, leadership in energy and environmental design; M, R, and R, maintenance, repair, and replacement; MARR, minimum average rate of return; NIST, National Institute of Standards and Technology; NREL, National Renewable Energy Laboratory; tCO2e, ton of carbon dioxide equivalent. * Tel.: +1 301 975 6857; fax: +1 301 975 4032. E-mail address: joshua.kneifel@nist.gov.
Progress in digital integrated electronics [Technical literaiture, Copyright 1975 IEEE. Reprinted, with permission. Technical Digest. International Electron Devices Meeting, IEEE, 1975, pp. 11-13.]

This article is reprinted from the Internaional Electron Devices Meeting (1975). It discusses the complexity of integrated circuits, identifies their manufacture, production, and deployment, and addresses trends to their future deployment.
Dosimetric rationale and early experience at UFPTI of thoracic proton therapy and chemotherapy in limited-stage small cell lung cancer.

BACKGROUND
Concurrent chemoradiotherapy (CRT) is the standard of care in patients with limited-stage small cell lung cancer (SCLC). Treatment with conventional x-ray therapy (XRT) is associated with high toxicity rates, particularly acute grade 3+ esophagitis and pneumonitis. We present outcomes for the first known series of limited-stage SCLC patients treated with proton therapy and a dosimetric comparison of lung and esophageal doses with intensity-modulated radiation therapy (IMRT).


MATERIAL AND METHODS
Six patients were treated: five concurrently and one sequentially. Five patients received 60-66 CGE in 30-34 fractions once daily and one patient received 45 CGE in 30 fractions twice daily. All six patients received prophylactic cranial irradiation. Common Terminology Criteria for Adverse Events, v3.0, was used to grade toxicity. IMRT plans were also generated and compared with proton plans.


RESULTS
The median follow-up was 12.0 months. The one-year overall and progression-free survival rates were 83% and 66%, respectively. There were no cases of acute grade 3+ esophagitis or acute grade 2+ pneumonitis, and no other acute grade 3+ non-hematological toxicities were seen. One patient with a history of pulmonary fibrosis and atrial fibrillation developed worsening symptoms four months after treatment requiring oxygen. Three patients died: two of progressive disease and one after a fall; the latter patient was disease-free at 36 months after treatment. Another patient recurred and is alive, while two patients remain disease-free at 12 months of follow-up. Proton therapy proved superior to IMRT across all esophageal and lung dose volume points.


CONCLUSION
In this small series of SCLC patients treated with proton therapy with radical intent, treatment was well tolerated with no cases of acute grade 3+ esophagitis or acute grade 2+ pneumonitis. Dosimetric comparison showed better sparing of lung and esophagus with proton therapy. Proton therapy merits further investigation as a method of reducing the toxicity of CRT.
Visual 3-D SLAM from UAVs

The aim of the paper is to present, test and discuss the implementation of Visual SLAM techniques to images taken from Unmanned Aerial Vehicles (UAVs) outdoors, in partially structured environments. Every issue of the whole process is discussed in order to obtain more accurate localization and mapping from UAVs flights. Firstly the issues related to the visual features of objects in the scene, their distance to the UAV and the related image acquisition system features and their calibration are evaluated for improving the whole process. Other important, considered issues are related to the image processing techniques, such as interest point detection, the matching procedure and the scaling factor. The whole system has been tested using the COLIBRI mini UAV in partially structured environments. The results that have been obtained for localization, tested against the GPS information of the flights, show that Visual SLAM delivers reliable localization and mapping that makes it suitable for some outdoors applications when flying UAVs.
A pilot study of oxaliplatin, fluorouracil and folinic acid (FOLFOX-6) as first-line chemotherapy in advanced or recurrent gastric cancer.

BACKGROUND
To evaluate the efficacy and toxicity of an oxaliplatin, fluorouracil (5-FU), and folinic acid (FOLFOX-6) combination therapy in patients with advanced or recurrent gastric cancer.


METHODS
Patients with previously untreated advanced or recurrent gastric cancer received oxaliplatin 100 mg/m(2) and leucovorin 400 mg/m(2) (2-hour intravenous infusion) followed by a 5-FU bolus of 400 mg/m(2) (10-min infusion) and then 5-FU 2,600-3,000 mg/m(2) (46-hour continuous infusion). The chemotherapy was repeated every 14 days.


RESULTS
Fifty-one patients were enrolled in this study. Of these, 46 were assessable for efficacy, and all patients were assessable for toxicity. Three of 51 patients achieved a complete response, and 18 had partial responses, giving an overall response rate of 41.2%. Stable disease was observed in 11 (21.6%) patients and progressive disease in 14 (27.5%). The median time to progression was 5.4 months, and the median overall survival was 12.1 months. NCI-CTC grade 3/4 hematological toxicities were neutropenia and anemia in 9.8 and 7.8% of the patients, respectively. Grade 3 peripheral neuropathy was recorded in 3 (5.9%) patients. Other NCI-CTC grade 3 or 4 toxicities included diarrhea in 3 patients (5.9%) and vomiting in 5 (9.8%). There were no treatment-related deaths.


CONCLUSIONS
This oxaliplatin/5-FU/folinic acid regimen shows good efficacy and an acceptable toxicity profile in advanced or recurrent gastric cancer patients; further clinical trials are warranted.
Correction: The Nerve Growth Factor Receptor CD271 Is Crucial to Maintain Tumorigenicity and Stem-Like Properties of Melanoma Cells

BACKGROUND
Large-scale genomic analyses of patient cohorts have revealed extensive heterogeneity between individual tumors, contributing to treatment failure and drug resistance. In malignant melanoma, heterogeneity is thought to arise as a consequence of the differentiation of melanoma-initiating cells that are defined by cell-surface markers like CD271 or CD133.


RESULTS
Here we confirmed that the nerve growth factor receptor (CD271) is a crucial determinant of tumorigenicity, stem-like properties, heterogeneity and plasticity in melanoma cells. Stable shRNA mediated knock-down of CD271 in patient-derived melanoma cells abrogated their tumor-initiating and colony-forming capacity. A genome-wide expression profiling and gene-set enrichment analysis revealed novel connections of CD271 with melanoma-associated genes like CD133 and points to a neural crest stem cell (NCSC) signature lost upon CD271 knock-down. In a meta-analysis we have determined a shared set of 271 differentially regulated genes, linking CD271 to SOX10, a marker that specifies the neural crest. To dissect the connection of CD271 and CD133 we have analyzed 10 patient-derived melanoma-cell strains for cell-surface expression of both markers compared to established cell lines MeWo and A375. We found CD271+ cells in the majority of cell strains analyzed as well as in a set of 16 different patient-derived melanoma metastases. Strikingly, only 2/12 cell strains harbored a CD133+ sub-set that in addition comprised a fraction of cells of a CD271+/CD133+ phenotype. Those cells were found in the label-retaining fraction and in vitro deduced from CD271+ but not CD271 knock-down cells.


CONCLUSIONS
Our present study provides a deeper insight into the regulation of melanoma cell properties and points CD271 out as a regulator of several melanoma-associated genes. Further, our data strongly suggest that CD271 is a crucial determinant of stem-like properties of melanoma cells like colony-formation and tumorigenicity.
3-T MRI reveals cranial and thoracic inflammatory changes in giant cell arteritis

Giant cell arteritis (GCA) is a diagnostic challenge. The correct diagnosis is needed for immediate initiation of corticosteroid treatment since blindness is a dreaded complication. Typically, the superficial cranial arteries are affected by this granulomatous vasculitis of large- and medium-sized arteries. However, GCA is not limited to the cranial arteries. Involvement of various arteries such as the cervical and thoracic arteries can also occur. Here, we report a case of histologically proven GCA with cranial and extracranial involvement. We illustrate the usefulness of a comprehensive vascular high-resolution magnetic resonance imaging examination that combines assessment of mural inflammatory changes of the small temporal and occipital arteries with the evaluation of extracranial vasculature to assist in the difficult non-invasive diagnosis and to determine the extent of this inflammatory disease.
Software-Defined Networks for Future Networks and Services

In 2013, the IEEE Future Directions Committee (FDC) formed an SDN work group to explore the amount of interest in forming an IEEE Software-Defined Network (SDN) Community. To this end, a Workshop on “SDN for Future Networks and Services” (SDN4FNS’13) was organized in Trento, Italy (Nov. 11-13 2013). Following the results of the workshop, in this paper, we have further analyzed scenarios, prior-art, state of standardization, and further discussed the main technical challenges and socio-economic aspects of SDN and virtualization in future networks and services. A number of research and development directions have been identified in this white paper, along with a comprehensive analysis of the technical feasibility and business availability of those fundamental technologies. A radical industry transition towards the “economy of information through softwarization” is expected in the near future. Keywords—Software-Defined Networks, SDN, Network Functions Virtualization, NFV, Virtualization, Edge, Programmability, Cloud Computing.
Modelling the long term impact of climate change on the carbon budget of Lake Simcoe, Ontario using INCA-C.

This study presents a process-based model of dissolved organic carbon concentration ([DOC]) in catchments draining into Lake Simcoe, Ontario. INCA-C, the Integrated Catchment model for Carbon, incorporates carbon biogeochemical processes in a terrestrial system with hydrologic flow paths to simulate watershed wide [DOC]. The model successfully simulates present-day inter-annual and seasonal [DOC] dynamics in tributaries draining catchments with mixed or contrasting land cover in the Lake Simcoe watershed (LSW). The sensitivity of INCA-C to soil moisture, hydrologic controls and land uses within a watershed demonstrates its significance as a tool to explore pertinent environmental issues specific to the LSW. Projections of climate change under A1B and A2 SRES scenarios suggest a continuous monotonic increase in [DOC] in surface waters draining into Lake Simcoe. Large variations in seasonal DOC dynamics are predicted to occur during summer with a possibility of displacement of summer [DOC] maxima towards winter and a prolongation of summer [DOC] levels into the autumn. INCA-C also predicts possible increases in dissolved inorganic carbon in some tributaries with rising temperature suggesting increased CO(2) emissions from rivers as climate changes.