LLukas22/scidocs huggingface dataset:
What are the best outcome measures for assessing quality of life in plaque type psoriasis? A systematic review of the literature.

BACKGROUND
The assessment of health-related quality of life (QOL) is important in psoriasis. Despite this, among the wide variety of QOL questionnaires used in psoriasis, there is no consensus as to which is the best.


OBJECTIVE
The objective of this systematic review was to identify which of these measurements have acceptable evaluation criteria for both monitoring disease and research purposes. We looked at validity, reliability, sensitivity to change (responsiveness) and acceptability, which are common criteria for any score and specific criteria for QOL questionnaire.


MATERIALS AND METHODS
We performed a systematic review of all clinical studies investigating the QOL of psoriasis patients, published between January 1988 and June 2009.


RESULTS
Twenty-one QOL questionnaires were identified. Eight of these satisfied most of the validation criteria; they were multidimensional and had been used in clinical research: short form 36 (SF 36), Dermatology Life Quality Index (DLQI), Skindex 29, Skindex 17, Dermatology Quality of life Scale (DQOLS), Psoriasis Disability Index (PDI) Impact of Psoriasis Questionnaire (IPSO) and Psoriasis Index of Quality of Life (PSORIQOL). Construct validity, content validity and internal consistency were adequately assessed and good performance was achieved for all questionnaires. Reproducibility (undetermined for Skindex 17) and acceptability were good for all questionnaires. Sensitivity to change was determined good for the SF36, DLQI, Skindex 29 and PDI. Item bias, unidimensional structure and cross-cultural equivalence were poor for all but the Skindex 17 and SF36 questionnaires.


CONCLUSION
On the basis of this systematic review, we can conclude that the DLQI is easy to use in clinical practice because of its brevity and simplicity. SF36 is widely used in clinical trials. Skindex 29 and Skindex 17, although rarely used, are interesting because of their cross-cultural validation.
Endoscopic placement of a tracheal oxygen catheter: a new technique

Objective: In patients with chronic obstructive pulmonary disease (COPD), intratracheal oxygen insufflation (ITO) is an established therapeutic approach. We developed a new endoscopic technique of intratracheal catheter placement. The aim of this pilot study was to demonstrate its short-term feasibility in acutely extubated patients with moderate to severe COPD who require oxygen therapy. Design: A guide wire was inserted through a nasally passed bronchoscope and was positioned such that its tip was placed intratracheally. Using a “Seldinger technique“, the tracheal catheter was then inserted over the wire to a point 2–3 cm proximal to the carina and positioned under direct vision from the bronchoscope inserted through the contralateral nose. After catheter insertion, the guide wire was removed. The patients scored catheter-associated local discomfort using a visual analogue scale. In a randomly assigned, crossover design, the effectiveness of the endoscopically (e) inserted ITO catheter was assessed by measuring the capillary blood gases, respiratory rate (RR), tidal volume (Vt) and minute ventilation (MV) after 1 h breathing room air without eITO and 1 h after eITO (flow: 3 l/min). Measurements and results: The eITO catheter was placed in all patients without complications and with only minimal discomfort in two patients (spontaneously reversible cough). Compared to breathing room air, capillary O2 pressure increased (from 54.7 ± 9.4 to 82.8 ± 21.8 mmHg) whereas Vt (from 458.7 ± 86.8 to 358.3 ± 75.1 ml) and MV (from 7.7 ± 1.5 to 5.5 ± 1.1 l/min) decreased significantly (each p < 0.0001) with eITO in all patients. The capillary CO2 pressure and RR did not change. Conclusions: Acutely extubated patients in whom oxygen therapy is indicated may profit from eITO. This new technique works immediately and is thus an effective short-term intervention of potential value in the intensive care unit.
Fully Homomorphic Encryption without Bootstrapping

We present a radically new approach to fully homomorphic encryption (FHE) that dramatically improves performance and bases security on weaker assumptions. A central conceptual contribution in our work is a new way of constructing leveled fully homomorphic encryption schemes (capable of evaluating arbitrary polynomial-size circuits), without Gentry’s bootstrapping procedure. Specifically, we offer a choice of FHE schemes based on the learning with error (LWE) or ring-LWE (RLWE) problems that have 2 security against known attacks. For RLWE, we have: • A leveled FHE scheme that can evaluate L-level arithmetic circuits with Õ(λ · L) per-gate computation – i.e., computation quasi-linear in the security parameter. Security is based on RLWE for an approximation factor exponential in L. This construction does not use the bootstrapping procedure. • A leveled FHE scheme that uses bootstrapping as an optimization, where the per-gate computation (which includes the bootstrapping procedure) is Õ(λ), independent of L. Security is based on the hardness of RLWE for quasi-polynomial factors (as opposed to the sub-exponential factors needed in previous schemes). We obtain similar results for LWE, but with worse performance. We introduce a number of further optimizations to our schemes. As an example, for circuits of large width – e.g., where a constant fraction of levels have width at least λ – we can reduce the per-gate computation of the bootstrapped version to Õ(λ), independent of L, by batching the bootstrapping operation. Previous FHE schemes all required Ω̃(λ) computation per gate. At the core of our construction is a much more effective approach for managing the noise level of lattice-based ciphertexts as homomorphic operations are performed, using some new techniques recently introduced by Brakerski and Vaikuntanathan (FOCS 2011). ∗Sponsored by the Air Force Research Laboratory (AFRL). Disclaimer: This material is based on research sponsored by DARPA under agreement number FA8750-11-C-0096 and FA8750-11-2-0225. The U.S. Government is authorized to reproduce and distribute reprints for Governmental purposes notwithstanding any copyright notation thereon. The views and conclusions contained herein are those of the authors and should not be interpreted as necessarily representing the official policies or endorsements, either expressed or implied, of DARPA or the U.S. Government. Approved for Public Release, Distribution Unlimited. †This material is based on research sponsored by DARPA under Agreement number FA8750-11-2-0225. All disclaimers as above apply.
Inflammatory, immune-mediated adverse reactions related to soft tissue dermal fillers.

BACKGROUND
An increasing number of persons seek medical solutions for esthetic indications and for diverse pathological conditions, such as malformations, trauma, or cancer. Despite manufacturers' and different authors' claims that fillers are non-immunogenic or that complications are uncommon, unwanted adverse reactions do occur.


OBJECTIVES
To review the literature regarding the multiple types of immune-mediated adverse reactions related to medical dermal filler injections/prosthesis.


METHODS
A comprehensive MEDLINE, PubMed, and Google Scholar electronic database search was performed (2000-January 2012). Selected articles published before 2000 referring to general concerns regarding the studied topic were also included. The search provided almost 300 articles. Finally, 235 studies were selected and included.


RESULTS
All known fillers present in the market have been shown to be able to provoke early- and late-onset inflammatory adverse reactions. Their true prevalence is unknown but appears to be significant. The majority of the late-onset adverse effects are inflammatory and immune-mediated in nature. Edema, granulomas, sarcoid-like disorders, and panniculitis are the findings most commonly seen. Rarely, systemic granulomatous and autoimmune diseases, and to lesser extent acute hypersensitivity reactions can be seen.


CONCLUSIONS
All implanted, injected, and blood-contact biomaterials trigger a wide variety of adverse reactions that may appear early or late and range from local to systemic. Most fillers act more as adjuvants than as direct T-cell activators, on a background of genetic predisposition. Their treatment has not been the subject of well-designed studies. Management of both acute and systemic reactions is often difficult and requires anti-inflammatory and occasionally immunosuppressive therapy.
Books, Places, Regions—A Natural Blend

Abstract Children love books, and through carefully chosen ones geographic concepts can be conveyed. Books are good resources—great background material for describing a place, emphasizing the culture of a region, highlighting a geographical issue, or clarifying where a place is in the world. This article explains how literature encourages geographic thinking, builds geographic skills, and develops lasting mental maps of places and regions.
Septal flash predicts cardiac resynchronization therapy response in patients with permanent atrial fibrillation.

AIMS
Patients with heart failure (HF) as well as atrial fibrillation (AF) have suboptimal response to cardiac resynchronization therapy (CRT). Identification of mechanical abnormalities, amenable to correction with CRT, might improve the selection of candidates and CRT efficiency. We evaluated whether abnormal septal motion, assessed by the presence of septal flash (SF) is related to CRT response in patients with AF.


METHODS AND RESULTS
Ninety-four CRT patients with AF were included. Echocardiography was performed in all subjects at baseline and at 12-month follow-up. Abnormal septal motion was defined by the presence of SF (early septal inward/outward motion within the isovolumic contraction period/QRS duration). Response to CRT was defined as a reduction (>15%) of the end-systolic volume of the left ventricle (LV). Univariate and multivariate analyses were performed to identify the predictors of CRT response. The mean age was 69 ± 8 years, 79% were males, and 59% of patients responded to CRT. Cardiovascular death was 14.4% and all-cause mortality was 16.5% during follow-up. Patients with SF at baseline that was acutely corrected by CRT were significantly more likely to respond than patients without SF. Baseline SF was an independent predictor of CRT response (OR 5.24; 95% CI 1.95-14.11).


CONCLUSION
Abnormal septal motion, assessed by the presence of SF, is a mechanism amenable to CRT correction. Its correction is associated with a higher likelihood of CRT response in HF patients with long-standing AF. This could improve the selection of candidates to CRT in a subgroup with particularly poor response and long-term prognosis.
Rigour and grounded theory research.

BACKGROUND
Grounded theory methodology is a suitable qualitative research approach for clinical inquiry into nursing practice, leading to theory development in nursing. Given the variations in, and subjectivity attached to, the manner in which qualitative research is carried out, it is important for researchers to explain the process of how a theory about a nursing phenomenon was generated. Similarly, when grounded theory research reports are reviewed for clinical use, nurses need to look for researchers' explanations of their inquiry process.


AIM
The focus of this article is to discuss the practical application of grounded theory procedures as they relate to rigour.


METHOD
Reflecting on examples from a grounded theory research study, we suggest eight methods of research practice to delineate further Beck's schema for ensuring, credibility, auditability and fittingness, which are all components of rigour.


FINDINGS
The eight methods of research practice used to enhance rigour in the course of conducting a grounded theory research study were: (1) let participants guide the inquiry process; (2) check the theoretical construction generated against participants' meanings of the phenomenon; (3) use participants' actual words in the theory; (4) articulate the researcher's personal views and insights about the phenomenon explored; (5) specify the criteria built into the researcher's thinking; (6) specify how and why participants in the study were selected; (7) delineate the scope of the research; and (8) describe how the literature relates to each category which emerged in the theory.


CONCLUSIONS
The eight methods of research practice should be of use to those in nursing research, management, practice and education in enhancing rigour during the research process and for critiquing published grounded theory research reports.
Employee relationship and knowledge sharing: a case study of a Taiwanese finance and securities firm

Received: 26 July 2003 Accepted: 11 December 2003 Abstract Knowledge is a very important resource for preserving valuable heritage, learning new things, solving problems, creating core competences, and initiating new situations for both individual and organizations now and in the future. Knowledge sharing may be a power to encourage knowledge exchange and creation in the organizations in order to recognize their competitive advantages – the brainpower or intellectual capital. In this paper, we propose statistical hypotheses and implement statistical tests in a branch of a Taiwanese finance and securities firm in order to investigate the issue of employee relationship within the case firm, together with the attitudes and intentions toward knowledge sharing with their colleagues. By testing four hypotheses, we find that the relationship between some employees and the case firm is good, and those employees would like to share working knowledge and experience with colleagues voluntarily and unconditionally. On the other hand, the relationship between some employees and the case firm is not probably good, and those employees are reluctant to share working knowledge and experience with colleagues or under some conditional terms. Some research findings propose as managerial issue for discussion and future work. Finally, this paper concludes that the success of knowledge sharing in organizations, depend not only technological means, but is also related to behavioral factors. Knowledge Management Research & Practice (2004) 2, 24–34. doi:10.1057/palgrave.kmrp.8500016
Pharmacological characterization of CP-547,632, a novel vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for cancer therapy.

Signaling through vascular endothelial growth factor (VEGF) receptors (VEGFRs) is a key pathway initiating endothelial cell proliferation and migration resulting in angiogenesis, a requirement for human tumor growth and metastasis. Abrogation of signaling through VEGFR by a variety of approaches has been demonstrated to inhibit angiogenesis and tumor growth. Small molecule inhibitors of VEGFR tyrosine kinase have been shown to inhibit angiogenesis, inhibit tumor growth, and prevent metastases. Our goal was to discover and characterize an p.o. active VEGFR-2 small molecule inhibitor. A novel isothiazole, CP-547,632, was identified as a potent inhibitor of the VEGFR-2 and basic fibroblast growth factor (FGF) kinases (IC(50) = 11 and 9 nM, respectively). It is selective relative to epidermal growth factor receptor, platelet-derived growth factor beta, and other related TKs. It also inhibits VEGF-stimulated autophosphorylation of VEGFR-2 in a whole cell assay with an IC(50) value of 6 nM. After oral administration of CP-547,632 to mice bearing NIH3T3/H-ras tumors, VEGFR-2 phosphorylation in tumors was inhibited in a dose-dependent fashion (EC(50) = 590 ng/ml). These plasma concentrations correlated well with the observed concentrations of the compound necessary to inhibit VEGF-induced corneal angiogenesis in BALB/c mice. A sponge angiogenesis assay was used to directly compare the inhibitory activities of CP-547,632 against FGF receptor 2 or VEGFR-2; this compound potently inhibits both basic FGF and VEGF-induced angiogenesis in vivo. The antitumor efficacy of this agent was evaluated after once daily p.o. administration to athymic mice bearing human xenografts and resulted in as much as 85% tumor growth inhibition. CP-547,632 is a well-tolerated, orally-bioavailable inhibitor presently under clinical investigation for the treatment of human malignancies.
Visualization of PLC programs using XML

Due to the growing complexity of PLC programs there is an increasing interest in the application of formal methods in this area. Formal methods allow rigid proving of system properties in verification and validation. One way to apply formal methods is to utilize a formal design approach in PLC programming. However, for existing software that has to be optimized, changed, or ported to new systems there is the need for an approach that can start from a given PLC program. Therefore, formalization of PLC programs is a topic of current research. This paper outlines a re-engineering approach based on the formalization of PLC programs. The transformation into a vendor independent format and the visualization of the structure of PLC programs are identified as an important intermediate step in this process. It is shown how XML and corresponding technologies can be used for the formalization and visualization of an existing PLC program.
A 201.4 GOPS 496 mW Real-Time Multi-Object Recognition Processor With Bio-Inspired Neural Perception Engine

A 201.4 GOPS real-time multi-object recognition processor is presented with a three-stage pipelined architecture. Visual perception based multi-object recognition algorithm is applied to give multiple attentions to multiple objects in the input image. For human-like multi-object perception, a neural perception engine is proposed with biologically inspired neural networks and fuzzy logic circuits. In the proposed hardware architecture, three recognition tasks (visual perception, descriptor generation, and object decision) are directly mapped to the neural perception engine, 16 SIMD processors including 128 processing elements, and decision processor, respectively, and executed in the pipeline to maximize throughput of the object recognition. For efficient task pipelining, proposed task/power manager balances the execution times of the three stages based on intelligent workload estimations. In addition, a 118.4 GB/s multi-casting network-on-chip is proposed for communication architecture with incorporating overall 21 IP blocks. For low-power object recognition, workload-aware dynamic power management is performed in chip-level. The 49 mm2 chip is fabricated in a 0.13 ¿m 8-metal CMOS process and contains 3.7 M gates and 396 KB on-chip SRAM. It achieves 60 frame/sec multi-object recognition up to 10 different objects for VGA (640 × 480) video input while dissipating 496 mW at 1.2 V. The obtained 8.2 mJ/frame energy efficiency is 3.2 times higher than the state-of-the-art recognition processor.
The role of moderating factors in user technology acceptance

Along with increasing investments in new technologies, user technology acceptance becomes a frequently studied topic in the information systems discipline. The last two decades have seen user acceptance models being proposed, tested, refined, extended and unified. These models have contributed to our understanding of user technology acceptance factors and their relationships. Yet they have also presented two limitations: the relatively low explanatory power and inconsistent influences of the factors across studies. Several researchers have recently started to examine the potential moderating effects that may overcome these limitations. However, studies in this direction are far from being conclusive. This study attempts to provide a systematic analysis of the explanatory and situational limitations of existing technology acceptance studies. Ten moderating factors are identified and categorized into three groups: organizational factors, technological factors and individual factors. An integrative model is subsequently established, followed by corresponding propositions pertaining to the moderating factors. r 2005 Elsevier Ltd. All rights reserved.
The creation of virtual teeth with and without tooth pathology for a virtual learning environment in dental education.

PURPOSE
To describe the development and opportunities for implementation of virtual teeth with and without pathology for use in a virtual learning environment in dental education.


MATERIAL AND METHODS
The creation of virtual teeth begins by scanning a tooth with a cone beam CT. The resulting scan consists of multiple two-dimensional grey-scale images. The specially designed software program ColorMapEditor connects these two-dimensional images to create a three-dimensional tooth. With this software, any aspect of the tooth can be modified, including its colour, volume, shape and density, resulting in the creation of virtual teeth of any type.


RESULTS
This article provides examples of realistic virtual teeth with and without pathology that can be used for dental education. ColorMapEditor offers infinite possibilities to adjust and add options for the optimisation of virtual teeth.


DISCUSSION
Virtual teeth have unlimited availability for dental students, allowing them to practise as often as required. Virtual teeth can be made and adjusted to any shape with any type of pathology. Further developments in software and hardware technology are necessary to refine the ability to colour and shape the interior of the pulp chamber and surface of the tooth to enable not only treatment but also diagnostics and thus create a greater degree of realism.


CONCLUSION
The creation and use of virtual teeth in dental education appears to be feasible but is still in development; it offers many opportunities for the creation of teeth with various pathologies, although an evaluation of its use in dental education is still required.