LLukas22/scidocs huggingface dataset:
A conceptual overview of the virtual networking laboratory

A state-of-the-art networking lab is expensive to create and operate. This paper provides a conceptual overview of the Virtual Networking Laboratory (VNL). The VNL offers educational materials that provide networking technicians hands-on training beyond that received in a traditional, physical laboratory setting. Using the VNL, technicians can install, configure and maintain emulated networks of arbitrary size within a single computer. Students would verify the proper configuration of the network, and troubleshoot systems to identify and correct improperly configured components. Built-in assessment tools automatically track and report skill mastery. Breaking the dependency on the physical networking laboratory means that this training could be delivered using distance learning technology, further expanding access. The VNL system provides a cost effective means of supporting the national need to provide hands-on training to network technicians.
Analysis of arginine and lysine methylation utilizing peptide separations at neutral pH and electron transfer dissociation mass spectrometry.

Arginine and lysine methylation are widespread protein post-translational modifications. Peptides containing these modifications are difficult to retain using traditional reversed-phase liquid chromatography because they are intrinsically basic/hydrophilic and often fragment poorly during collision induced fragmentation (CID). Therefore, they are difficult to analyze using standard proteomic workflows. To overcome these caveats, we performed peptide separations at neutral pH, resulting in increased retention of the hydrophilic/basic methylated peptides before identification using MS/MS. Alternatively trifluoroacetic acid (TFA) was used for increased trapping of methylated peptides. Electron-transfer dissociation (ETD) mass spectrometry was then used to identify and characterize methylated residues. In contrast to previous reports utilizing ETD for arginine methylation, we observed significant amount of side-chain fragmentation. Using heavy methyl stable isotope labeling with amino acids in cell culture it was shown that, similar to CID, a loss of monomethylamine or dimethylamine from the arginine methylated side-chain during ETD can be used as a diagnostic to determine the type of arginine methylation. CID of lysine methylated peptides does not lead to significant neutral losses, but ETD is still beneficial because of the high charge states of such peptides. The developed LC MS/MS methods were successfully applied to tryptic digests of a number of methylated proteins, including splicing factor proline-glutamine-rich protein (SFPQ), RNA and export factor-binding protein 2 (REF2-I) and Sul7D, demonstrating significant advantages over traditional LC MS/MS approaches.
Cryptographic schemes based on elliptic curve pairings

Cryptographic Schemes based on Elliptic Curve Pairings: Contributions to Public Key Cryptography and Key Agreement Protocols This thesis introduces the concept of certificateless public key cryptography (CLPKC). Elliptic curve pairings are then used to make concrete CL-PKC schemes and are also used to make other efficient key agreement protocols. CL-PKC can be viewed as a model for the use of public key cryptography that is intermediate between traditional certificated PKC and ID-PKC. This is because, in contrast to traditional public key cryptographic systems, CL-PKC does not require the use of certificates to guarantee the authenticity of public keys. It does rely on the use of a trusted authority (TA) who is in possession of a master key. In this respect, CL-PKC is similar to identity-based public key cryptography (ID-PKC). On the other hand, CL-PKC does not suffer from the key escrow property that is inherent in ID-PKC. Applications for the new infrastructure are discussed. We exemplify how CL-PKC schemes can be constructed by constructing several certificateless public key encryption schemes and modifying other existing ID based schemes. The lack of certificates and the desire to prove the schemes secure in the presence of an adversary who has access to the master key or has the ability to replace public keys, requires the careful development of new security models. We prove that some of our schemes are secure, provided that the Bilinear Diffie-Hellman Problem is hard. We then examine Joux’s protocol [90], which is a one round, tripartite key agreement protocol that is more bandwidth-efficient than any previous three-party key agreement protocol, however, Joux’s protocol is insecure, suffering from a simple man-in-the-middle attack. We shows how to make Joux’s protocol secure, presenting several tripartite, authenticated key agreement protocols that still require only one round of communication. The security properties of the new protocols are studied. Applications for the protocols are also discussed.
Migraine Associated with Gastrointestinal Disorders: Review of the Literature and Clinical Implications

Recent studies suggest that migraine may be associated with gastrointestinal (GI) disorders, including irritable bowel syndrome (IBS), inflammatory bowel syndrome, and celiac disease. Here, an overview of the associations between migraine and GI disorders is presented, as well as possible mechanistic links and clinical implications. People who regularly experience GI symptoms have a higher prevalence of headaches, with a stronger association with increasing headache frequency. Children with a mother with a history of migraine are more likely to have infantile colic. Children with migraine are more likely to have experienced infantile colic compared to controls. Several studies demonstrated significant associations between migraine and celiac disease, inflammatory bowel disease, and IBS. Possible underlying mechanisms of migraine and GI diseases could be increased gut permeability and inflammation. Therefore, it would be worthwhile to investigate these mechanisms further in migraine patients. These mechanisms also give a rationale to investigate the effects of the use of pre- and probiotics in migraine patients.
Introduction of imatinib as first-line therapy for chronic myeloid leukemia in Cuba.

INTRODUCTION
Chronic myeloid leukemia is the first malignant disease to be associated with a genetic lesion and is the first leukemia to provide a genotype model conducive to targeted molecular therapy. It is a chronic clonal myeloproliferative disorder, originating in a pluripotent stem cell common to all three hematopoietic lineages, characterized by overproduction of myeloid cells in all stages of maturation. Approval of the use of imatinib in the United States in 2001 and its introduction in the treatment of chronic myeloid leukemia changed the evolution and prognosis of the disease and began the era of molecular therapy for malignancies. Imatinib is highly effective and causes fewer adverse reactions than earlier treatments based on interferon and hydroxyurea. In Cuba, chronic myeloid leukemia has been treated with interferon since 1998. Starting in 2003, imatinib was gradually introduced for use in newly-diagnosed chronic myeloid leukemia patients.


OBJECTIVE
Evaluate the use of imatinib as first-line therapy for chronic myeloid leukemia in a group of Cuban patients, based on hematologic, cytogenetic, and molecular response; overall and event-free survival rates; and most frequency and severity of adverse reactions.


METHODS
During May 2003 to May 2008, 33 newly-diagnosed chronic myeloid leukemia patients (25 adults, 8 children; <6 months from diagnosis) received a single daily oral dose of imatinib 400 mg from the time of study enrollment. Variables used: (1) to evaluate treatment efficacy: hematologic, cytogenetic, and molecular response; overall and event-free survival; and (2) to evaluate safety: presence of adverse reactions leading to definitive interruption of treatment or death.


RESULTS
Complete hematologic response occurred in 100% of patients, major cytogenetic response in 90.9%, and complete cytogenetic response in 48.5%. Molecular response occurred in 36.4% of patients. With a mean follow-up of 39 months, overall survival was 96% and estimated five-year event-free survival was 85%. No adverse reactions occurred in 39.5% of patients. Adverse reactions most frequently observed were myelosuppression (24.2%) and digestive disorders (21.2%). These were followed, in decreasing order, by edema, primarily orbital (9.1%), skin depigmentation (3%), and cardiac arrhythmias (3%).


CONCLUSIONS
In the present study, imatinib was effective first-line therapy for patients with newly-diagnosed chronic myeloid leukemia, as determined by overall and event-free survival rates. No severe adverse reactions were observed.
The prognostic importance of comorbidity for mortality in patients with stable coronary artery disease.

OBJECTIVES
To identify the prevalent and prognostically important coexisting illnesses among single coronary artery disease (CAD) patients.


BACKGROUND
As the population ages, physicians are increasingly required to make decisions concerning patients with multiple co-existing illnesses (comorbidity). Many trials of CAD therapy have excluded patients with significant comorbidity, such that there are limited data to guide the management of those patients.


METHODS
To consider the long-term prognostic importance of comorbid illness, we examined a cohort of 1471 patients with CAD who underwent cardiac catheterization between 1985 and 1989 and were followed up through 2000 in the Duke Databank for Cardiovascular Diseases. Weights were assigned to individual diseases according to their prognostic significance in Cox proportional hazards models, thus creating a new CAD-specific index. The new index was compared with the widely used Charlson index, according to prevalence of conditions, individual and overall associations with survival, and agreement.


RESULTS
The Charlson index and the CAD-specific index were highly associated with long-term survival and almost equivalent to left ventricular ejection fraction. When considering the components of the Charlson index, diabetes, renal insufficiency, chronic obstructive pulmonary disease, and peripheral vascular disease had greater prognostic significance among CAD patients, whereas peptic ulcer disease, connective tissue disease, and lymphoma were less significant. Hemiplegia, leukemia, lymphoma, severe liver disease, and acquired immunodeficiency syndrome were rarely identified among patients undergoing coronary angiography.


CONCLUSIONS
Comorbid disease is strongly associated with long-term survival in patients with CAD. These data suggest co-existing illnesses should be measured and considered in clinical trials, disease registries, quality comparisons, and counseling of individual patients.
Unipolar and Bipolar PWM Inverter

Inverter is basically an interface between DC source like photovoltaic cell and AC networks. There are many inverter topologies but output current distortion and efficiency are the two main parameters for the selection of inverters. Two such topologies are described herein. In this paper, the SPWM (Sinusoidal Pulse Width Modulation) technique of unipolar and bipolar inverters is presented and the models are simulated in MATLAB – Simulink. The H-Bridge inverter topologies (both unipolar and bipolar) are made up of power electronic switches and are fed with constant amplitude pulses with varying duty cycle for each period. The SPWM pulses are generated by comparison of two wavesa carrier wave, which is triangular in this case and a modulating reference wave whose frequency is the desired frequency, which is sinusoidal in this case. This pulse width modulation inverter is characterized by simple circuitry and rugged control scheme that is SPWM technique to obtain inverter output voltage control and to reduce its harmonic content.
"Low-field" intraoperative MRI: a new scenario, a new adaptation.

AIM
To describe the adaptation of Cruces University Hospital to the use of intraoperative magnetic resonance imaging (ioMRI), and how the acquisition and use of this technology would impact the day-to-day running of the neurosurgical suite.


MATERIALS AND METHODS
With the approval of the ethics committee, an observational, prospective study was performed from June 2012 to April 2014, which included 109 neurosurgical procedures with the assistance of ioMRI. These were performed using the Polestar N-30 system (PSN30; Medtronic Navigation, Louisville, CO), which was integrated into the operating room.


RESULTS
A total of 159 procedures were included: 109 cranial surgeries assisted with ioMRI and 50 control cases (no ioMRI use). There were no statistical significant differences when anaesthetic time (p=0.587) and surgical time (p=0.792) were compared; however, an important difference was shown in duration of patient positioning (p<0.0009) and total duration of the procedure (p<0.0009) between both groups.


CONCLUSIONS
The introduction of ioMRI is necessary for most neurosurgical suites; however, a few things need to be taken into consideration when adapting to it. Increase procedure time, the use of specific MRI-safe devices, as well as a checklist for each patient to minimise risks, should be taken into consideration.
Endoscopic versus microscopic transsphenoidal pituitary adenoma surgery: a meta-analysis

BACKGROUND
Endoscopic transsphenoidal surgery has gradually come to be regarded as a preferred option in the treatment of pituitary adenomas because of its advantages of improved visualization and its minimal invasiveness. The aim of this study was to compare and evaluate the outcomes and complications of endoscopic and microscopic transsphenoidal surgery in the treatment of pituitary adenomas.


METHODS
We performed a systematic literature search of MEDLINE, EMBASE, the Cochrane Library and the Web of Science between January 1992 and May 2013. Studies with consecutive patients that explicitly and fully compared endoscopic and microscopic approaches in the treatment of pituitary adenomas were included.


RESULTS
A total of 15 studies (n = 1,014 patients) met the inclusion criteria among 487 studies that involved endoscopic surgery and 527 studies that dealt with microscopic surgery. The rate of gross tumor removal was higher in the endoscopic group than in the microscopic group. The post-operative rates of septal perforation were less frequent in patients who underwent endoscopic surgery. There was no significant difference between the two techniques in the incidence rates of meningitis, diabetes insipidus, cerebrospinal fluid leak, epistaxis or hypopituitarism. The post-operative hospital stay was significantly shorter for the endoscopic surgery group compared with the microscopic surgery group (P < 0.05). There was no significant difference in the length of the operation (P > 0.05).


CONCLUSIONS
The present study indicates that the endoscopic transsphenoidal approach is safer and more effective than microscopic surgery in the treatment of pituitary adenomas.
EFFECTS OF ICT CONNECTEDNESS, PERMEABILITY, FLEXIBILITY, AND NEGATIVE SPILLOVERS ON BURNOUT AND JOB AND FAMILY SATISFACTION

This study investigates the effects of information and communication technologies (ICTs), permeability, flexibility, and spillovers of work into home and home into work on job burnout and job and family satisfaction. Results from a random sample of 612 office workers show that individuals who reported being satisfied with their jobs tended to feel that the Internet could help them accomplish work-related tasks, that traditional media could help them relax after work, and had a highly permeable boundary between their home domain and a highly flexible work environment. On the other hand, people who experienced low job satisfaction faced high work spillovers into home life and high burnout. The findings underscore that the connectedness of ICTs is not the main issue for assessing the consequences associated with ICTs. Rather, individual control over what passes through the boundaries shapes the consequences people experience.
Eye-position dependence of three-dimensional ocular rotation-axis orientation during head impulses in humans

 If horizontal saccades or smooth-pursuit eye movements are made with the line-of-sight at different elevations, the three-dimensional (3D) angular rotation axis of the globe tilts by half the vertical eye eccentricity. This phenomenon is named ”half-angle rule” and is a consequence of Listing’s law. It was recently found that the ocular rotation axis during the horizontal vestibulo-ocular reflex (VOR) on a turntable also tilts in the direction of the line-of-sight by about a quarter of the eye’s vertical eccentricity. This is surprising, since, in a ”perfect” VOR, the angular rotation axis of the eye should be independent from the position of the eye to fully compensate for the 3D angular head rotation. We asked whether this quarter-angle strategy is a general property of the VOR or whether the 3D kinematics of ocular movements evoked by vestibular stimulation would be less eye-position dependent at higher stimulus frequencies. Nine healthy subjects were exposed to horizontal head impulses (peak velocity ∼250°/s). The line-of-sight was systematically changed along the vertical meridian of a tangent screen. Three-dimensional eye and head movements were monitored with dual search coils. The 3D orientation of the angular eye-in-head rotation axis was determined by calculating the average angular velocity vectors of the initial 10° displacements. Then, the difference between the tilt angles of the ocular rotation axis during upward and downward viewing was determined and divided by the difference of vertical eccentricity (”tilt angle coefficient”). Control experiments included horizontal saccades, smooth-pursuit eye movements, and eye movements evoked by slow, passive head rotations at the same vertical eye eccentricities. On average, the ocular rotation axis during horizontal head-impulse testing at different elevations of the line-of-sight was closely aligned with the rotation axis of the head (tilt angle coefficient of pooled abducting and adducting eye movements: 0.11±0.17 SD). Values for slow head impulses, however, exceeded somewhat the quarter angle (0.33±0.12), while smooth-pursuit movements (0.50±0.09) and saccades (0.44±0.11) were closest to the half angle. These results demonstrate that the 3D orientation of the ocular rotation axis during rapid head thrusts is relatively independent of the direction of the line-of-sight and that ocular rotations elicited by head impulses are kinematically different from saccades, despite similar movement dynamics.
Chitosan/silk fibroin-based, Schwann cell-derived extracellular matrix-modified scaffolds for bridging rat sciatic nerve gaps.

Extracellular matrix (ECM) plays a prominent role in establishing and maintaining an ideal microenvironment for tissue regeneration, and ECM scaffolds are used as a feasible alternative to cellular and molecular therapy in the fields of tissue engineering. Because of their advantages over tissue-derived ECM scaffolds, cultured cell-derived ECM scaffolds are beginning to attract attention, but they have been scarcely studied for peripheral nerve repair. Here we aimed to develop a tissue engineered nerve scaffold by reconstituting nerve cell-derived ECM with natural biomaterials. A protocol was adopted to prepare and characterize the cultured Schwann cell (SC)-derived ECM. A chitosan conduit and silk fibroin (SF) fibers were prepared, cultured with SCs for ECM deposition, and subjected to decellularization, followed by assembly into a chitosan/SF-based, SC-derived ECM-modified scaffold, which was used to bridge a 10 mm rat sciatic nerve gap. The results from morphological analysis as well as electrophysiological examination indicated that regenerative outcomes achieved by our developed scaffold were similar to those by an acellular nerve graft (namely a nerve tissue-derived ECM scaffold), but superior to those by a plain chitosan/SF scaffold. Moreover, blood and histopathological parameters confirmed the safety of scaffold modification by SC-derived ECM. Therefore, a hybrid scaffold based on joint use of acellular and classical biomaterials represents a promising approach to nerve tissue engineering.
The magnitude of the association between smoking and the risk of developing cancer in Brazil: a multicenter study

OBJECTIVES
To estimate the magnitude of association and identify the aetiological fraction (AF) attributable to smoking in the development of different types of cancers in Brazil.


SETTING
We conducted a case-control study, including 231 102 patients registered in the Cancer Hospital Registries (CHR) in the period from 1998 to 2011.


PARTICIPANTS
A total of 204 131 cancer cases relating to 30 topographies were compared with 26 971 cases of non-melanoma skin cancer.


PRIMARY AND SECONDARY OUTCOME MEASURES
Smoking exposure was considered at the time of hospital registration. We calculated OR, unadjusted and adjusted for gender, age and alcohol consumption, with 95% CIs.


RESULTS
After adjustment, the risk of developing cancer associated with smoking was very high (piriform sinus, bronchi and lung, larynx, hypopharynx, oropharynx and oral cavity), high (oesophagus and bladder), moderate (anus and anal canal stomach, nasal cavity, middle ear and paranasal sinuses, pancreas, nasopharynx, other parts of the biliary tract and kidney and low (liver, gall)). There was no association between smoking and cancers of the central nervous system and myeloid leukaemia. For thyroid cancer there was a decreased risk of developing the disease. The AF was higher than 50% for hypopharynx, larynx, bronchi and lung, oropharynx, oral cavity and oesophagus cancers.


CONCLUSIONS
This study confirms a high risk of developing cancer of the hypopharynx, bronchi and lung, larynx, oropharynx and oral cavity, oesophagus and bladder cancer among smokers and establishes the AF attributable to smoking in the development of different types of cancer in Brazil.
The Role of Strategic Information Systems (SIS) in Supporting and Achieving the Competitive Advantages (CA): An Empirical Study on Saudi Banking Sector

The purpose of this research paper is to identify the significant role of Strategic Information Systems (SIS) in supporting the Competitive Advantage (CA). It also explains its role on the dimensions that increase the competitive advantage which are the operational efficiency, information quality and innovation. In order to achieve the goal of this study and to collect the primary data, the researchers designed a survey, in the form of an electronic questionnaire. This survey instrument consisted of 20 questions. It was distributed to members of the study sample, which contains the managers at all levels, and the employees in the Saudi banking sector. The number of the participants included in the survey was 147. The results of this study revealed that there is a significant role of strategic information systems on increasing operational efficiency, improving the quality of information and promoting innovation. This in turn enabled the organizations to achieve higher levels of competitive advantages. The strategic information systems have deep consequences for organizations that adopt them; managers could achieve great and sustainable competitive advantages from such systems if carefully considered and developed. On the other hand, this study was conducted in the banking sector in KSA context. So, more research is needed in other sectors and in the context of other countries; to confirm and generalize the results. Finally, the paper’s primary value lies in its ability to provide the evidence that the strategic information systems play a significant role in supporting and achieving the competitive advantages in Saudi Arabia, particularly in the banking sector. Since there was a lack of such research in the Saudi context, this paper can provide a theoretical basis for future researchers as well as practical implications for managers. Keywords—Strategic information systems (SIS); competitive advantage (CA); operational efficiency; information quality; innovation