LLukas22/scidocs huggingface dataset:
Validation of glutathione quantitation from STEAM spectra against edited 1H NMR spectroscopy at 4T: application to schizophrenia

Objective: Quantitation of glutathione (GSH) in the human brain in vivo using short echo time 1 H NMR spectroscopy is challenging because GSH resonances are not easily resolved. The main objective of this study was to validate such quantitation in a clinically relevant population using the resolved GSH resonances provided by edited spectroscopy. A secondary objective was to compare several of the neurochemical concentrations quantified along with GSH using LCModel analysis of short echo time spectra in schizophrenia versus control. Materials and Methods: GSH was quantified at 4T from short echo STEAM spectra and MEGA-PRESS edited spectra from identical volumes of interest (anterior cingulate) in ten volunteers. Neurochemical profiles were quantified in nine controls and 13 medicated schizophrenic patients. Results: GSH concentrations as quantified using STEAM, 1.6 ± 0.4 μmol/g (mean ± SD, n=10), were within error of those quantified using edited spectra, 1.4 ± 0.4 μmol/g, and were not different (p=0.4). None of the neurochemical measurements reached sufficient statistical power to detect differences smaller than 10% in schizophrenia versus control. As such, no differences were observed. Conclusions: Human brain GSH concentrations can be quantified in a clinical setting using short-echo time STEAM spectra at 4T.
Extraction et analyse de la phase aqueuse de l'emmental à 4 stades d'affinage

Résumé Grâce à la mise au point d'un équipement prototype de pressage, une amélioration de la méthodologie d'extraction de la phase aqueuse des fromages proposée initialement par Barthel et al (1928a) a été réalisée. Les phases aqueuses d'emmental à 4 stades d'affinage: sortie saumure, entrée et sortie cave chaude, commercialisation, ont été extraites et caractérisées sur les plans bactériologique, physico-chimique et biochimique. La teneur en substance sèche initialement de 90 g/kg de phase aqueuse atteint 170 g/kg dans le fromage affiné. Cet accroissement découle de l'élévation (multiplication par 5) de la teneur en azote solubilisé du fait de la protéolyse, notamment lors de l'affinage en cave chaude; 56% de l'azote total déterminé dans le fromage affiné sont sous la forme d'acides aminés libres. L'évolution des teneurs en sucre et en acides organiques est conforme à leur métabolisation par les bactéries lactiques et propioniques (consommation de 25% du lactate majoritairement de la forme L). L'analyse des formes minérales montre une évolution considérable des sels phosphocalciques par rapport au lait: rapport Ca/P variant entre 8,2 et 5,4 au lieu de 1,3. Les teneurs en Na et CI ne sont pas en accord avec leurs proportions dans la molécule de NaCI, ce qui conduit à penser qu'une partie de l'ion CI est mobilisé dans d'autres formes salines du type chlorhydrate. La caractérisation de la phase aqueuse des fromages apparaît au travers de cette première étude comme une méthodologie privilégiée de suivi de la fabrication et de l'affinage des fromages.
Comparison of a traditional and a Video Game Based Balance Training Program

The aim of the present study is to compare the efficiency of traditional and video game based balance training programs. 22 customers of a health care centre (age: M = 47.6 yrs; SD = 13.1) volunteered to participate in the experiment. They were randomly assigned to two experimental groups. One group underwent a traditional training program, while the other group trained using the Nintendo Wii Fit TM Balance Board. Between pre and post test procedures, training sessions were performed three times a week for three weeks. In addition to five balance tests (SEBT, ball-handling, two video games, dynamic balance), a questionnaire was applied concerning mood state, self-efficacy, physical activity enjoyment, flow and subjective experience in order to evaluate psychological effects of the interventions. Two-factor analyses of variance showed both general and differential improvements of the two groups for pre and post test measures. Both groups improved their balance performance in 4 of five tests. The traditional group showed a significantly greater improvement in two tests (SEBT: F(1,20) = 8.907, p = .007, η2 = .308; ball-handling: F(1,20) = 13.578, p = .001, η2 = .404), whereas the Wii group showed a significantly greater improvement in one test (Ski Slalom (F(1,20) = 5.101, p = .035, η2 = .203). Psychological questionnaires revealed neither significant pre-post effects nor differences between the groups for pre and post test measurements. The results confirm that the Nintendo Wii Fit TM may be a suitable medium of training balance in prevention and rehabilitation of adults. Specific effects of training are more pronounced than transfer between virtual and real performance. BALANCE, VIDEO GAMES, NINTENDO Wii Fit , REHABILITATION, PREVENTION
The dark side of the sharing economy ... and how to lighten it

Improving the sharing economy will require addressing myriad problems.
Decomposing the GenderWage Gap with Sample Selection Adjustment: Evidence from Colombia

Despite the remarkable improvement of female labor market characteristics, a sizeable gender wage gap exists in Colombia. We employ quantile regression techniques to examine the degree to which current small differences in the distribution of observable characteristics can explain the gender gap. We find that the gap is largely explained by gender differences in the rewards to labor market characteristics and not by differences in the distribution of characteristics. We claim that Colombian women experience both a “glass ceiling effect’’ and also (what we call) a “quicksand floor effect” because gender differences in returns to characteristics primarily affect women at the top and the bottom of the distribution. Also, self selection into the labor force is crucial for gender gaps: if all women participated in the labor force, the observed gap would be roughly 50% larger at all quantiles.
Universal Prediction

This paper consists of an overview on universal prediction from an information-theoretic perspective. Special attention is given to the notion of probability assignment under the self-information loss function, which is directly related to the theory of universal data compression. Both the probabilistic setting and the deterministic setting of the universal prediction problem are described with emphasis on the analogy and the differences between results in the two settings.
An exact algorithm for team orienteering problems

Optimising routing of vehicles constitutes a major logistic stake in many industrial contexts. We are interested here in the optimal resolution of special cases of vehicle routing problems, known as team orienteering problems. In these problems, vehicles are guided by a reward that can be collected from customers, while the length of routes is limited. The main difference with classical vehicle routing problems is that not all customers have to be visited. The solution method we propose here is based on a Branch & Price algorithm. It is, as far as we know, the first exact method proposed for such problems, except for a preliminary work from Gueguen (Methodes de résolution exacte pour problémes de tournées de véhicules. Thése de doctorat, école Centrale Paris 1999) and a work from Butt and Ryan (Comput Oper Res 26(4):427–441 1999). It permits to solve instances with up to 100 customers.
Sorafenib and irinotecan (NEXIRI) as second- or later-line treatment for patients with metastatic colorectal cancer and KRAS-mutated tumours: a multicentre Phase I/II trial

Background:This trial evaluated the feasibility and efficacy of combined sorafenib and irinotecan (NEXIRI) as second- or later-line treatment of patients with KRAS-mutated metastatic colorectal cancer (mCRC), who had progressed after irinotecan-based chemotherapy.Methods:In Phase I, in a 3+3 dose escalation schedule, patients received irinotecan (125, 150 or 180 mg m−2 every 2 weeks), in combination with 400 mg sorafenib b.d. The primary end point was the maximum-tolerated dose of irinotecan. In Phase II, the primary end point was disease control rate (DCR). Secondary end points were progression-free survival (PFS), overall survival (OS) and toxicity.Results:Phase I included 10 patients (median age 63 (49–73)); no dose-limiting toxicity was seen. In Phase II, 54 patients (median age 60 (43–80) years) received irinotecan 180 mg m−2 every 2 weeks with sorafenib 400 mg b.d. Nine patients (17%) remained on full-dose sorafenib. The DCR was 64.9% (95% CI, 51–77). Median PFS and OS were 3.7 (95% CI, 3.2–4.7) and 8.0 (95% CI, 4.8–9.7) months, respectively. Toxicities included Grade 3 diarrhoea (37%), neutropenia (18%), hand-foot syndrome (13%) and Grade 4 neutropenia (17%).Conclusion:The NEXIRI regimen showed promising activity as second- or later-line treatment in this heavily pretreated mCRC population (ClinicalTrials.gov NCT00989469).
Mapping Large Loops with a Single Hand-Held Camera

This paper presents a method for Simultaneous Localization and Mapping (SLAM), relying on a monocular camera as the only sensor, which is able to build outdoor, closed-loop maps much larger than previously achieved with such input. Our system, based on the Hierarchical Map approach [1], builds independent local maps in real-time using the EKF-SLAM technique and the inverse depth representation proposed in [2]. The main novelty in the local mapping process is the use of a data association technique that greatly improves its robustness in dynamic and complex environments. A new visual map matching algorithm stitches these maps together and is able to detect large loops automatically, taking into account the unobservability of scale intrinsic to pure monocular SLAM. The loop closing constraint is applied at the upper level of the Hierarchical Map in near real-time. We present experimental results demonstrating monocular SLAM as a human carries a camera over long walked trajectories in outdoor areas with people and other clutter, even in the more difficult case of forward-looking camera, and show the closing of loops of several hundred meters.
Correlated Beliefs, Returns, and Stock Market Volatility

Firm-level stock returns exhibit comovement above that in fundamentals, and the gap tends to be higher in developing countries. We investigate whether correlated beliefs among sophisticated, but imperfectly informed, traders can account for the patterns of return correlations across countries. We take a unique approach by turning to direct data on market participants’ information namely, real-time firm-level earnings forecasts made by equity market analysts. The correlations of firm-level forecasts exceed those of fundamentals and are strongly related to return correlations across countries. A calibrated information-based model demonstrates that the correlation of beliefs implied by analyst forecasts leads to return correlations broadly in line with the data, both in levels and across countries the correlation between predicted and actual is 0.63. Our findings have implications for market-wide volatility the model-implied correlations alone can explain 44% of the cross-section of aggregate volatility. The results are robust to controlling for a number of alternative factors put forth by the existing literature. JEL Classification: G15, G12, G17, D8
MAGNETIC FIELD PRODUCED BY A TILE PERMANENT MAGNET WHOSE POLARIZATION IS BOTH UNIFORM AND TANGENTIAL

This paper presents the exact 3D calculation of the magnetic field produced by a tile permanent magnet whose polarization is both tangential and uniform. Such a calculation is useful for optimizing magnetic couplings or for calculating the magnetic field produced by alternate magnet structures. For example, our 3D expressions can be used for calculating the magnetic field produced by a Halbach structure. All our expressions are determined by using the coulombian model. This exact analytical approach has always proved its accuracy and its usefulness. As a consequence, the tile permanent magnet considered is represented by using the fictitious magnetic pole densities that are located on the faces of the magnet. In addition, no simplifying assumptions are taken into account for calculating the three magnetic field components. Moreover, it is emphasized that the magnetic field expressions are fully three-dimensional. Consequently, the expressions obtained are valid inside and outside of the tile permanent magnet, whatever its dimensions. Such an approach allows us to realize easily parametric studies.
Basal and Adrenocorticotropic Hormone Stimulated Plasma Cortisol Levels Among Egyptian Autistic Children: Relation to Disease Severity

BACKGROUND
Autism is a disorder of early childhood characterized by social impairment, communication abnormalities and stereotyped behaviors. The hypothalamic-pituitary-adrenocortical (HPA) axis deserves special attention, since it is the basis for emotions and social interactions that are affected in autism.


AIM
To assess basal and stimulated plasma cortisol, and adrenocorticotropic hormone (ACTH) levels in autistic children and their relationship to disease characteristics.


METHODS
Fifty autistic children were studied in comparison to 50 healthy age-, sex- and pubertal stage- matched children. All subjects were subjected to clinical evaluation and measurement of plasma cortisol (basal and stimulated) and ACTH. In addition, electroencephalography (EEG) and intelligence quotient (IQ) assessment were done for all autistic children.


RESULTS
Sixteen% of autistic patients had high ACTH, 10% had low basal cortisol and 10% did not show adequate cortisol response to ACTH stimulation. Autistic patients had lower basal (p = 0.032) and stimulated cortisol (p = 0.04) and higher ACTH (p = 0.01) than controls. Childhood Autism Rating Scale (CARS) score correlated positively with ACTH (r = 0.71, p = 0.02) and negatively with each of basal (r = -0.64, p = 0.04) and stimulated cortisol (r = -0.88, p < 0.001). Hormonal profile did not differ in relation to EEG abnormalities, IQ and self- aggressive symptoms.


CONCLUSIONS
The observed hormonal changes may be due to a dysfunction in the HPA axis in autistic individuals. Further studies are warranted regarding the role of HPA axis dysfunction in the pathogenesis of autism.
Sentiment classification: The contribution of ensemble learning

Article history: Received 27 August 2012 Received in revised form 1 August 2013 Accepted 5 August 2013 Available online 15 August 2013
Emotion-focused family therapy for eating disorders in children and adolescents.

UNLABELLED
Family-based therapy (FBT) is regarded as best practice for the treatment of eating disorders in children and adolescents. In FBT, parents play a vital role in bringing their child or adolescent to health; however, a significant minority of families do not respond to this treatment. This paper introduces a new model whereby FBT is enhanced by integrating emotion-focused therapy (EFT) principles and techniques with the aims of helping parents to support their child's refeeding and interruption of symptoms. Parents are also supported to become their child's 'emotion coach'; and to process any emotional 'blocks' that may interfere with their ability to take charge of recovery. A parent testimonial is presented to illustrate the integration of the theory and techniques of EFT in the FBT model. EFFT (Emotion-Focused Family Therapy) is a promising model of therapy for those families who require a more intense treatment to bring about recovery of an eating disorder.


KEY PRACTITIONER MESSAGE
More intense therapeutic models exist for treatment-resistant eating disorders in children and adolescents. Emotion is a powerful healing tool in families struggling with an eating disorder. Working with parent's emotions and emotional reactions to their child's struggles has the potential to improve child outcomes.
Digital Double-loop PID Controller for Inverted Pendulum

Inverted pendulum system is a complicated, unstable and multivariable nonlinear system. In order to control the angle and displacement of inverted pendulum system effectively, a novel double-loop digital PID control strategy is presented in this paper. Based on impulse transfer function, the model of the single linear inverted pendulum system is divided into two parts according to the controlled parameters. The inner control loop that is formed by the digital PID feedback control can control the angle of the pendulum, while in order to control the cart displacement, the digital PID series control is adopted to form the outer control loop. The simulation results show the digital control strategy is very effective to single inverted pendulum and when the sampling period is selected as 50 ms, the performance of the digital control system is similar to that of the analog control system. Copyright © 2013 IFSA.
Football incident analysis: a new video based method to describe injury mechanisms in professional football.

OBJECTIVES
To develop and test a new video based method for match analysis that combines football specific and medical information to achieve a better understanding of the injury mechanisms and events leading up to high risk situations.


METHODS
Football incident analysis (FIA) is a video based method describing incidents that may result in an injury using 19 variables and categories modified from match analysis. Videos from 35 of 76 (46%) official Norwegian under 21 matches played from 1994 to 1998 were analysed. Two football experts classified each incident on the basis of predetermined criteria, and their results were compared using interobserver and intraobserver reliability tests.


RESULTS
kappa correlation coefficients for interobserver and intraobserver agreement were very good for 63% and 95% and good for 37% and 5% of the variables respectively. Fifty two incidents were recorded (1.6 incidents per team per match or 94 per 1000 player hours), and 16 (31%) led to injuries (0.5 injuries per match or 29 injuries per 1000 player hours). FIA results showed that 28 incidents occurred while attacking in midfield zone 2 or the attacking zone, and 24 took place while defending in the defensive zone or midfield zone 1. Midfielders were exposed in 67% of the incidents, mainly in breakdown attacks or during long attacks by the opposing team. Of the 28 incidents during offence, only one was classified as having great potential to score a goal. Most incidents (70%) were the result of tackling duels both in the offensive and defensive playing phases. Of the 21 offensive incidents resulting from tackling duels, in 19 cases the exposed player was unaware of the tackling (passive duellist).


CONCLUSIONS
This study shows that football incident analysis is a potentially valuable tool for understanding the events leading up to injuries in football.
Collective action in culturally similar and dissimilar groups: an experiment on parochialism, conditional cooperation, and their linkages ☆,☆☆

This study examines the effects of ingroup favoritism and outgroup hostility (“parochialism”), as well as of conditionally cooperative strategies, in explaining contributions to experimental public goods games. The experimental conditions vary group composition along two culturally inheritable traits (political party preference and religious affiliation) and one trivial, “minimal” trait (birth season). We contrast ingroup, outgroup, and random group conditions and investigate the relation between the own contribution to the public good and the expectations about other group members' behavior in each one of them. We find evidence for ingroup favoritism but no support for a separate tendency towards outgroup hostility. Further, conditional cooperation and ingroup bias are, to some extent, linked. Subjects had higher expectations of the contributions of ingroup members, and their own behavior was more strongly conditioned on other group members' expected behavior in the ingroup conditions. In ingroup contexts, subjects displayed a form of “strong reciprocity” by giving more than they expected others to at high expectation levels but less at low expectation levels. Once these interactions are taken into account, we do not find a direct effect of ingroup bias anymore. We discuss these results in the light of theories of cultural group selection and conclude that too much emphasis may have been laid on direct intergroup conflict. Our results suggest that differential cooperativeness, rather than parochialism, may characterize the behavior of individuals in cultural ingroups and outgroups. © 2009 Elsevier Inc. All rights reserved.
Biological functions of hCG and hCG-related molecules

BACKGROUND
hCG is a term referring to 4 independent molecules, each produced by separate cells and each having completely separate functions. These are hCG produced by villous syncytiotrophoblast cells, hyperglycosylated hCG produced by cytotrophoblast cells, free beta-subunit made by multiple primary non-trophoblastic malignancies, and pituitary hCG made by the gonadotrope cells of the anterior pituitary.


RESULTS AND DISCUSSION
hCG has numerous functions. hCG promotes progesterone production by corpus luteal cells; promotes angiogenesis in uterine vasculature; promoted the fusion of cytotrophoblast cell and differentiation to make syncytiotrophoblast cells; causes the blockage of any immune or macrophage action by mother on foreign invading placental cells; causes uterine growth parallel to fetal growth; suppresses any myometrial contractions during the course of pregnancy; causes growth and differentiation of the umbilical cord; signals the endometrium about forthcoming implantation; acts on receptor in mother's brain causing hyperemesis gravidarum, and seemingly promotes growth of fetal organs during pregnancy. Hyperglycosylated hCG functions to promote growth of cytotrophoblast cells and invasion by these cells, as occurs in implantation of pregnancy, and growth and invasion by choriocarcinoma cells. hCG free beta-subunit is produced by numerous non-trophoblastic malignancies of different primaries. The detection of free beta-subunit in these malignancies is generally considered a sign of poor prognosis. The free beta-subunit blocks apoptosis in cancer cells and promotes the growth and malignancy of the cancer. Pituitary hCG is a sulfated variant of hCG produced at low levels during the menstrual cycle. Pituitary hCG seems to mimic luteinizing hormone actions during the menstrual cycle.
Pelagic and coastal sources of P‐wave microseisms: Generation under tropical cyclones

[1] Nonlinear wave‐wave interactions generate double‐ frequency (DF) microseisms, which include both surface waves (mainly Rayleigh‐type) and compressional (P) waves. Although it is unclear whether DF surface waves generated in deep oceans are observed on land, we show that beamforming of land‐based seismic array data allows detection of DF P waves generated by ocean waves from Super Typhoon Ioke in both pelagic and coastal regions. Two distinct spectral bands associated with different P‐wave source locations are observed. The short‐period DF band (0.16– 0.35 Hz) is dominated by P waves generated in the deep ocean by local wind seas under the storm. In contrast, P waves in the long‐period DF band (0.1–0.15 Hz) are weaker and generated closer to the coast of Japan from swell interactions. The accurate identification of DF P‐wave microseism source areas is useful to monitor ocean wave‐wave interactions due to tropical cyclones and to image Earth structure using ambient seismic noise. Citation: Zhang, J., P. Gerstoft, and P. D. Bromirski (2010), Pelagic and coastal sources of P‐wave microseisms: Generation under tropical cyclones, Geophys. Res. Lett., 37, L15301, doi:10.1029/2010GL044288.