LLukas22/scidocs huggingface dataset:
Functional Analysis of the Arlequin Mutant Corroborates the Essential Role of the ARLEQUIN/TAGL1 Gene during Reproductive Development of Tomato

Reproductive development of higher plants comprises successive events of organ differentiation and growth which finally lead to the formation of a mature fruit. However, most of the genetic and molecular mechanisms which coordinate such developmental events are yet to be identified and characterized. Arlequin (Alq), a semi-dominant T-DNA tomato mutant showed developmental changes affecting flower and fruit ripening. Sepals were converted into fleshy organs which ripened as normal fruit organs and fruits displayed altered ripening features. Molecular characterization of the tagged gene demonstrated that it corresponded to the previously reported tomato Agamous-like 1 (TAGL1) gene, the tomato ortholog of shatterproof MADS-box genes of Arabidopsis thaliana, and that the Alq mutation promoted a gain-of-function phenotype caused by the ectopic expression of TAGL1. Ectopic overexpression of TAGL1 resulted in homeotic alterations affecting floral organ identity that were similar to but stronger than those observed in Alq mutant plants. Interestingly, TAGL1 RNAi plants yielded tomato fruits which were unable to ripen. They displayed a yellow-orange color and stiffness appearance which are in accordance with reduced lycopene and ethylene levels, respectively. Moreover, pericarp cells of TAGL1 RNAi fruits showed altered cellular and structural properties which correlated to both decreased expression of genes regulating cell division and lignin biosynthesis. Over-expression of TAGL1 is able to rescue the non-ripening phenotype of rin and nor mutants, which is mediated by the transcriptional activation of several ripening genes. Our results demonstrated that TAGL1 participates in the genetic control of flower and fruit development of tomato plants. Furthermore, gene silencing and over-expression experiments demonstrated that the fruit ripening process requires the regulatory activity of TAGL1. Therefore, TAGL1 could act as a linking factor connecting successive stages of reproductive development, from flower development to fruit maturation, allowing this complex process to be carried out successfully.
Effect of knowledge of serum enzyme concentrations on doctors' interpretation of electrocardiographic manifestations in suspected myocardial infarction.

3 Berry FA Jr, Yarborough S, Yarborough N, Russell CM, Carpenter MA, Hendley JO. Transient bacteremia during dental manipulation in children. Pediatrics 1973;51:476-9. 4 Shanson DC, Thomas F, Wilson D. Effect of volume of blood cultured on detection of Streptococcus viridans bacteraemia. J Clin Pathol 1984;37:568-79. 5 Newsom SWB. Antibiotic prophylaxis for open-heart surgery. J Antimicrob Chemother 1978;4: 389-91.
“[The] Things What Happened with Our Family”: Property and Inheritance in August Wilson's The Piano Lesson1

ABSTRACT This article examines how property operates in August Wilson's The Piano Lesson. It locates particular questions about property within the historical context of the play's setting and delineates notions of black property and inheritance both in relation to and in contradistinction to the tradition of white property rights and privilege. The author also explains how the piano (as property) functions as both a divisive and a unifying family member among the Charleses.
Diagnostic value of intraoperative examination of sentinel lymph node in early cervical cancer: a prospective, multicenter study.

OBJECTIVES
Sentinel lymph node (SLN) biopsy is a surgical procedure proposed in early cervical cancer. This technique yields the potential interest to reduce the morbidity of complete lymphadenectomy, which could then be performed only in case of positive SLN. Intraoperative examination has a major per-operative role in predicting nodal involvement and preventing a second step procedure. The aim of this study was to assess the diagnostic value of intraoperative examination with frozen section (FS) or imprint cytology (IC) of SLNs in early cervical cancer.


METHODS
Prospective study in 7 centers (01/2005-06/2007) including patients with stage IA1 and lymphovascular space involvement to IB1 cervical cancer (squamous cell carcinoma, adenocarcinoma or adenosquamous carcinoma). SLNs were detected with a combined method (Tc99m+blue dye) and then removed laparoscopically. Intraoperative examination (FS or IC) was not systematically performed but recommended in case of macroscopical nodal enlargement in 5 centers. Results of intraoperative examination were compared with final histology performed by Hematoxylin-Eosin-Safran staining and immunohistochemistry. The diagnostic value of intraoperative examination was calculated.


RESULTS
One hundred and thirty-nine patients were analyzed in the study. The combined detection rate was 97.8% per patient, with 454 detected SLNs. One hundred and two patients (73.4%) had an intraoperative examination (97 patients with FS and 5 with IC). Among patients with intraoperative examination, 5 SLNs were positive (all with macrometastasis at final histology), as compared with 22 metastatic nodes at final result. The 17 false negative SLNs were: 4 macrometastasis, 4 micrometastasis and 9 isolated tumor cells. Sensitivity of the intraoperative examination per node was 20.7% [95%CI: 7.8%-45.4%] and the negative predictive value 93.0% [95%CI: 89.0%-95.9%].


CONCLUSIONS
Intraoperative examination of SLNs by FS and IC has a poor diagnostic value. This is mainly related to micrometastasis and isolated tumor cells, which are not detected by intraoperative techniques. Other techniques, like new molecular assays, should be investigated to improve intraoperative assessment of SLNs.
Effect of self-reported sexual arousal on responses to sex-related and non-sex-related disgust cues.

Prior to and during sexual intercourse, people are exposed to stimuli that in other contexts might act as disgust-eliciting cues. This study examined whether sexual arousal, in contrast to general arousal, could selectively reduce reported disgust for cues that pilot participants identified as sex or non-sex related. Male undergraduates were randomly assigned to one of four viewing groups. One group viewed erotic female images, a second clad female images, a third pleasantly arousing images (e.g., skydiving), and a fourth unpleasantly arousing images (e.g., an aimed gun). After the viewing phase, all participants were exposed to pairs of real disgust elicitors (sex versus non-sex related) drawn from various sensory modalities. Participants in the erotic images group, who rated being more sexually aroused than those in the other three groups, also reported being significantly less disgusted by sex-related elicitors. While the mechanism for this effect is not currently known, our findings suggest one plausible explanation for risky sexual behavior as well as having implications for the role of disgust in sexual dysfunction.
Fault Location Method Based on Single-End Measurements for Underground Cables

The fault location in underground cables is characterized as the technical difficulties due to complexities in cables. Based on the direct circuit analysis, a fault location algorithm for underground cables with no laterals is presented in this paper. The single-end phasor measurements, including the voltages and currents sampled in the substation side, are utilized to locate the single phase faults in the typical single-conductor cross-linked polyethylene (XLPE) cables rated at the medium voltage (MV) levels. The distinctive cable characteristics are considered, such as relatively large capacitance, effects of sheaths and sheath bonding methods. The different fault scenarios are taken into account as well. The effect of changes of cable parameters and application of static response load model are also investigated. The simulation studies demonstrate the proposed algorithm can achieve the high accuracy under various system and fault conditions.
Adjudication of etiology of acute kidney injury: experience from the TRIBE-AKI multi-center study

BACKGROUND
Adjudication of patient outcomes is a common practice in medical research and clinical trials. However minimal data exists on the adjudication process in the setting of Acute Kidney Injury (AKI) as well as the ability to judge different etiologies (e.g. Acute Tubular Necrosis (ATN), Pre-renal Azotemia (PRA)).


METHODS
We enrolled 475 consecutive patients undergoing cardiac surgery at four sites of the Translational Research Investigating Biomarker Endpoints in AKI (TRIBE-AKI) study. Three expert nephrologists performed independent chart review, utilizing clinical variables and retrospective case report forms with pre intra and post-operative data, and then adjudicated all cases of AKI (n = 67). AKI was defined as a > 50% increase in serum creatinine for baseline (RIFLE Risk). We examined the patterns of AKI diagnoses made by the adjudication panel as well as association of these diagnoses with pre and postoperative kidney injury biomarkers.


RESULTS
There was poor agreement across the panel of reviewers with their adjudicated diagnoses being independent of each other (Fleiss' Kappa = 0.046). Based on the agreement of the two out of three reviewers, ATN was the adjudicated diagnosis in 41 cases (61%) while PRA occurred in 13 (19%). Neither serum creatinine or any other biomarker of AKI (urine or serum), was associated with an adjudicated diagnosis of ATN within the first 24 post-operative hours.


CONCLUSION
The etiology of AKI after cardiac surgery is probably multi-factorial and pure forms of AKI etiologies, such as ATN and PRA may not exist. Biomarkers did not appear to correlate with the adjudicated etiology of AKI; however the lack of agreement among the adjudicators impacted these results.


TRIAL REGISTRATION
Clinicaltrials.gov: NCT00774137.
Question Generation from Paragraphs at UPenn: QGSTEC System Description

This paper describes the question generation system developed at UPenn for QGSTEC, 2010. The system uses predicate argument structures of sentences along with semantic roles for the question generation task from paragraphs. The semantic role labels are used to identify relevant parts of text before forming questions over them. The generated questions are then ranked to pick final six best questions.
Computer vision based road traffic accident and anomaly detection in the context of Bangladesh

Road traffic accident is one of the major causes of death in Bangladesh. In this article, we propose a method that uses road side video data to learn the traffic pattern and uses vision based techniques to track and determine various kinetic features of vehicles. Finally, the proposed method detects anomaly (possibility of accident) and accidents on the road. The proposed method shows approximately 85% accuracy level in detecting special situations.
Underpricing of New Equity Offerings by Privatized Firms: An International Test

In this paper, we study a large sample of 507 privatization offerings from 39 countries over the period 1979-1996. Our objectives are twofold. First, we document the extent of short-run underpricing of these privatization offerings and measure their variation across countries, industries, and years, as well as drawing comparisons to private company IPOs. Second, we test alternative explanations of the determinants of short-run underpricing drawing on various models of maximizing behavior by underwriters, augmented by variables that proxy for national political objectives. Overall, we find support for elements of asymmetric information theory, investor sentiment theory and the reputation building hypothesis. With the exception of the Gini coefficient, our political proxy variables are typically not significant. Thus to a significant degree, the investment banking strategies believed to characterize IPOs of private companies in industrial countries may also play a role in the IPO strategies of state-owned-enterprises in both industrial and lesser developed economies. JEL classification: G15, G24
Closed-loop identification of an industrial robot containing flexibilities

Closed loop identification of an industrial robot of the type ABB IRB 1400 is considered. Using data collected when the robot is subject to feedback control and moving around axis one linear black-box and physically parameterized models are identified. A main purpose is to model the mechanical flexibilities and it is found that the dynamics of the robot can be well approximated by a model consisting of three-masses connected by springs and dampers. It also found that the results of the identification depend on the properties of the input signal.
Make it SIMPLE: enhanced shock management by focused cardiac ultrasound

BACKGROUND
Shock is a spectrum of circulatory failure that, if not properly managed, would lead to high mortality. Special diagnostic and treatment strategies are essential to save lives. However, clinical and laboratory findings are always non-specific, resulting in clinical dilemmas.


MAIN CONTENT
Focused cardiac ultrasound (FoCUS) has emerged as one of the power tools for clinicians to answer simple clinical questions and guide subsequent management in hypotensive patients. This article will review the development and utility of FoCUS in different types of shock. The sonographic features and ultrasound enhanced management of hypotensive patients by a de novo "SIMPLE" approach will be described. Current evidence on FoCUS will also be reviewed.


CONCLUSION
Focused cardiac ultrasound provides timely and valuable information for the evaluation of shock. It helps to improve the diagnostic accuracy, narrow the possible differential diagnoses, and guide specific management. SIMPLE is an easy-to-remember mnemonic for non-cardiologists or novice clinical sonographers to apply FoCUS and interpret the specific sonographic findings when evaluating patients in shock.
Generating Test Plans for Acceptance Tests from UML Activity Diagrams

The Unified Modeling Language (UML) is the standard to specify the structure and behaviour of software systems. The created models are a constitutive part of the software specification that serves as guideline for the implementation and the test of software systems. In order to verify the functionality which is defined within the specification documents, the domain experts need to perform an acceptance test. Hence, they have to generate test cases for the acceptance test. Since domain experts usually have a low level of software engineering knowledge, the test case generation process is challenging and error-prone. In this paper we propose an approach to generate high-level acceptance test plans automatically from business processes. These processes are modeled as UML Activity Diagrams (ACD). Our method enables the application of an all-path coverage criterion to business processes for testing software systems.
Arch2030: A Vision of Computer Architecture Research over the Next 15 Years

Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation. 1 Summary Application trends, device technologies and the architecture of systems drive progress in information technologies. However,
Large loop versus straight-wire excision of the transformation zone for treatment of cervical intraepithelial neoplasia: a randomised controlled trial of electrosurgical techniques.

OBJECTIVE
To compare two electrosurgical techniques, straight-wire excision of transformation zone (SWETZ) with large loop excision of transformation zone, as a cone procedure (LLETZ-cone), for the treatment of cervical intraepithelial neoplasia (CIN), when disease is present at the cervical canal.


DESIGN
Randomised controlled trial.


SETTING
Two public hospitals, one in Rio de Janeiro, Brazil and one in Dublin, Ireland.


POPULATION
One hundred and three women with indication to treat CIN located at cervical canal.


METHODS
Women were randomised to receive LLETZ-cone or SWETZ.


OUTCOMES
Main outcome was the incidence of complete excision of disease at endocervical margin of the surgical specimen. Secondary outcomes were complete excision at ectocervical and stromal margins, time to complete the procedure, specimen fragmentation, blood loss and death after 1 year.


RESULTS
Fifty-two women were allocated to LLETZ-cone and 51 to SWETZ. Ten women were lost for main outcome because of damaged specimens. Forty-two women in the LLETZ-cone group had free endocervical margin versus 43 women in the SWETZ group (relative risk 1.04, 95% confidence interval [95% CI] 0.87-1.25; P = 0.64). For secondary outcomes related to margins, we observed a relative risk of 1.15 (95% CI 0.95-1.39; P = 0.15) for ectocervical free margin. For free stromal margin, the relative risk was 1.07 (95% CI 0.89-1.29; P = 0.47). No death was observed.


CONCLUSIONS
This study was inconclusive; SWETZ and LLETZ-cone were equally effective to treat endocervical disease, with no difference in protecting against margin involvement. Higher, but not severe, blood loss and longer surgical time were observed in the SWETZ group.
Celebrity Endorsement : A Strategic Promotion Perspective DR

Introduction Strategic Positioning and effective communication are the two most important “mantras” guiding brand success in today’s competitive marketing environment. Corporate are ensuring all possible efforts to promote their brands and to grab the customer’s mind share. The impetus is on attracting the customer’s attention and developing positive associations not just to influence recall but also to induce trial and eventually effect purchase decisions.
Psychological Stress and Welfare in Fish

Galhardo L, Oliveira RF. Psychological Stress and Welfare in Fish. Annu Rev Biomed Sci 2009;11:1-20. The ability to respond to stress is vital to the survival of any living organism, though sustained reactions can become detrimental to the health and welfare of animals. Stress responses of vertebrates are known through several studies in their physiological, behavioural and psychological components, under acute and chronic contexts. In fish, the physiological and behavioural aspects of stress are considerably well known phenomena and show striking similarities to those of other vertebrates. However, the psychological component is not well known. Some authors deny mental experiences to fish on the basis of their lack of neocortex. Nevertheless, recent studies have shown neuroendocrine, cognitive and emotional processes in fish that are not only equivalent to other vertebrates, but also allow inferring some forms of mental representation. The integration of psychological elements in fish stress physiology is insufficiently studied, but, as discussed in this article, there is already indirect evidence to admit that some form of stimuli appraisal can take place in fish. This fact has profound implications on the regulation of the stress response, as well as on fish welfare and its management. ©by São Paulo State University ISSN 1806-8774
An economic analysis of online streaming music services

Streaming music services represent the music industry’s greatest prospective source of revenue and are well established among consumers. This paper presents a theory of a streaming music business model consisting of two types of services provided by a monopolist. The first service, which offers access free of charge, is of low quality and financed by advertising. The second service charges its users and is of high quality. The analysis demonstrates that if users are highly tolerant of commercials, the monopolist benefits from advertising funding and hence charges a high price to users of the fee-based service to boost demand for the advertising supported service. The analysis addresses the welfare consequences of such a business model and shows it is an effective policy for combating digital piracy. 2013 Elsevier B.V. All rights reserved.
Exploitation of Cross-Site Scripting (XSS) Vulnerability on Real World Web Applications and its Defense

Attacks on web applications are growing rapidly with the opening of new technologies, HTML tags and JavaScript functions. Cross-Site Scripting (XSS) vulnerabilities are being exploited by the attackers to steal web browser's resources (cookies, credentials etc. ) by injecting the malicious JavaScript code on the victim's web applications. The existing techniques like filtering of tags and special characters, maintaining a list of vulnerable sites etc. cannot eliminate the XSS vulnerabilities completely. In this paper, initially we have tried out the experiments on the exploitation of XSS vulnerabilities using local host server (i. e. XAMPP). After this, we have investigated for the XSS vulnerabilities on social networking sites (like Facebook, Orkut, Blogs, Twitter etc. ) and tried to exploit the same on blogs. Finally, on the basis of some analysis and results, we have discussed a novel technique of mitigating this XSS vulnerability by introducing a Sandbox environment on the web browser.
Surgically Managed Clinical Stage IIIA-Clinical N2 Lung Cancer in The Society of Thoracic Surgeons Database.

BACKGROUND
The role of surgical resection in patients with clinical stage IIIA-N2 positive (cIIIA-N2) lung cancer is controversial, partly because of the variability in short- and long-term outcomes. The objective of this study was to characterize the management of cIIIA-N2 lung cancer in The Society of Thoracic Surgeons General Thoracic Surgery Database (STS-GTSD).


METHODS
The STS-GTSD was queried for patients who underwent operations for cIIIA-N2 lung cancer between 2002 and 2012. A subset of patients aged older than 65 years was linked to Medicare data.


RESULTS
Identified were 3,319 surgically managed, cIIIA-N2 patients, including 1,784 (54%) treated with upfront resection (treatment naïve upfront surgery group, and 1,535 (46%) with induction therapy. A positron emission tomography scan was documented in 93% of patients, and 51% of patients were coded in STS-GTSD as having undergone invasive mediastinal staging. Nodal overstaging (cN2→pN0/N1) was observed in 43% of upfront surgery patients. Lobectomy was performed in 69% of patients and pneumonectomy in 11%. Operative mortality was similar between patients treated with upfront surgery (1.9%) and induction therapy (2.5%, p = .2583). The unadjusted Kaplan-Meier estimate of 5-year survival of cIII-N2 patients treated with induction therapy then resection was 35%.


CONCLUSIONS
STS surgeons achieve excellent short- and long-term results treating predominantly lobectomy-amenable cIIIA-N2 lung cancer. However, prevalent overstaging and abstention from induction therapy suggest "overcoding" of false positives on imaging or variable compliance with current guidelines for cIIIA-N2 lung cancer. Efforts are needed to improve clinical stage determination and guideline compliance in the GTSD for this cohort.
Political Status of Puerto Rico: Options for Congress [June 7, 2011]

This report discusses the current U.S.-Puerto Rico relationship, the history of said relationship, and the current political state of Puerto Rico, as well as relevant pieces of U.S. Congressional legislation concerning Puerto Rico.