LLukas22/scidocs huggingface dataset:
A cone-ratio DEA approach for AMT justification

Evaluation and selection of advanced manufacturing technology (AMT) is a complex decision making process which requires careful consideration of various performance criteria. Initially, the decision-maker must identify a feasible set of AMT candidates, which broadly meet the budget constraints and system requirements. The competitive priorities (cost, time, quality, and #exibility) must then be set and matched against the performance variables in identifying preference relationships. The "nal step involves the evaluation of alternative systems based on performance criteria and preference relationships. This paper depicts the AMT selection process through an IDEF0 functional model. It utilizes a combination of a cone-ratio data envelopment analysis (CRDEA), which integrates decision-maker's preferences, and a new methodological extension in data envelopment analysis (DEA). The applicability of the proposed model is illustrated by using a real data set of industrial robots. ( 2000 Elsevier Science B.V. All rights reserved.
Cilostazol could ameliorate platelet responsiveness to clopidogrel in patients undergoing primary percutaneous coronary intervention.

BACKGROUND
Cilostazol increases the cyclic adenosine monophosphate levels in platelets and might ameliorate the antiplatelet activity of clopidogrel. This study investigated the additional effect of cilostazol on platelet aggregation measured by a VerifyNow analyzer and soluble CD40 ligand (sCD40L) as a marker of activated platelet in patients undergoing primary percutaneous coronary intervention (PCI).


METHODS AND RESULTS
Sixty cases of primary PCI were randomly assigned to dual (aspirin and clopidogrel) or triple (dual plus cilostazol) therapy. The antiplatelet effects of aspirin and clopidogrel were evaluated by VerifyNow tests. The plasma sCD40L levels at admission, 24 h and 21 days were measured by the ELISA method. The arachidonic acid induced platelet aggregation was similar in both groups. However, the triple group had a significantly lower P2Y12 reaction unit (dual 208.8+/-69.0 vs triple 168.2+/-79.2, p=0.041) and higher % inhibition of adenosine diphosphate (ADP)-induced platelet aggregation (dual 23.8+/-21.4% vs triple 40.5+/-21.0%, p=0.004). In the multivariate analysis, cilostazol was a negative predictor for low responders to clopidogrel (95% confidence interval 0.067-0.711). The plasma sCD40L levels were not significantly different between the 2 groups at the same point of time.


CONCLUSIONS
The addition of cilostazol to the combination of aspirin plus clopidogrel significantly increases the inhibition of ADP-induced platelet aggregation. However, there was no additive effect on aspirin-induced antiplatelet activity or lowering of sCD40L.
Putative copper- and zinc-binding motifs in Streptococcus pneumoniae identified by immobilized metal affinity chromatography and mass spectrometry.

The aim of metalloproteomics is to identify and characterize putative metal-binding proteins and metal-binding motifs. In this study, we performed a systematical metalloproteomic analysis on Streptococcus pneumoniae through the combined use of efficient immobilized metal affinity chromatography enrichment and high-accuracy linear ion trap-Orbitrap MS to identify metal-binding proteins and metal-binding peptides. In total, 232 and 166 putative metal-binding proteins were respectively isolated by Cu- and Zn-immobilized metal affinity chromatography columns, in which 133 proteins were present in both preparations. The putative metalloproteins are mainly involved in protein, nucleotide and carbon metabolisms, oxidation and cell cycle regulation. Based on the sequence of the putative Cu- and Zn-binding peptides, putative Cu-binding motifs were identified: H(X)mH (m=0-11), C(X)(2) C, C(X)nH (n=2-4, 6, 9), H(X)iM (i=0-10) and M(X)tM (t=8 or 12), while putative Zn-binding motifs were identified as follows: H(X)mH (m=1-12), H(X)iM (i=0-12), M(X)tM (t=0, 3 and 4), C(X)nH (n=1, 2, 7, 10 and 11). Equilibrium dialysis and inductively coupled plasma-MS experiments confirmed that the artificially synthesized peptides harboring differential identified metal-binding motifs interacted directly with the metal ions. The metalloproteomic study presented here suggests that the comparably large size and diverse functions of the S. pneumoniae metalloproteome may play important roles in various biological processes and thus contribute to the bacterial pathologies.
Greenlight photoselective 120-watt 532-nm lithium triborate laser vaporization prostatectomy in living canines.

PURPOSE
Efficiency, anatomic, and histopathologic outcomes of GreenLight HPS 120-W, 532-nm lithium triborate (LBO) laser photoselective vaporization of the prostate (PVP) in a survival model of living canines were studied and compared with the outcomes of the only benchmarked survival study of 60-W 532-nm potassium-titanyl-phosphate (KTP) laser PVP in living canines.


MATERIALS AND METHODS
Twelve dogs underwent anterograde PVP with the 120-W LBO laser and, 4 each, were euthanized 3 hours (acute), 3 days (early), or 8 weeks (chronic) postoperatively. Laser energy and time were recorded. Prostates were sectioned, measured, and histologically analyzed after hematoxylin and eosin (H&E), triphenyltetrazolium chloride (TTC), or Gomori trichrome (GT) staining and compared with a normal control.


RESULTS
LBO laser PVP at 120 W acutely created a 6.7 +/- 3.2 cm(3) cavity, hemostatically, and vaporized tissue 160% more efficiently (mean 1.3 cm(3)/min vs 0.5 cm(3)/min), 500% faster (mean 4.9 vs 29.1 min), and needed 121% less energy (mean 28.8 vs 63.6 kJ) than the 60-W KTP laser. Histologic staining with H&E and TTC demonstrated a coagulation zone of 1.5 +/- 0.3 mm for the 120-W LBO laser, comparable to the 1 to 2 mm for the 60-W KTP laser. H&E- and GT-stained, healed prostates at 8-weeks postoperatively showed reepithelialized cavities with minimal submucosal fibrosis compared with an identically stained normal and the benchmarked KTP laser PVP-treated prostates.


CONCLUSION
Our in vivo canine survival study demonstrates GreenLight HPS 120-W, 532-nm LBO laser PVP has substantially more vaporization efficiency and speed, with equally favorable tissue interaction and healing vis-à-vis those benchmarked for the 532-nm wavelength by KTP laser PVP.
Aiding off-road inertial navigation with high performance models of wheel slip

When GPS, or other absolute positioning, is un-available, terrain-relative velocity is crucial for dead reckoning and the vehicle's pose estimate. Unfortunately, the position-denied accuracy of the inertial navigation system (INS) is governed by the performance of the linear velocity aiding sources, such as wheel odometry, which are typically corrupted by large systematic errors due to wheel slip. As a result, affordable terrestrial inertial navigation is ineffective in estimating position when denied position fixes for an extended period of time. For mobile robots, the mapping between inputs and resultant behavior depends critically on terrain conditions which vary significantly over time and space which cannot be pre-programmed. Past work has used Integrated Perturbative Dynamics (IPD) to identify successively systematic and stochastic models of wheel slip, but treated the pose filter only as input without improving the odometry measurements used for vehicle navigation. We present a unique approach of a predictive vehicle slip model in a delayed state extended Kalman filter. The relative pose difference between the current state and delayed state is used as a measurement update to the vehicle slip model. These results create an opportunity to compensate for wheel slip effects in terrestrial inertial navigation. This paper presents the design, calibration, and verification of such a system and concludes that the position-denied performance of the compensated system is far superior.
A virtual electrical drive control laboratory: Neuro-fuzzy control of induction motors

Neural and fuzzy courses are widely offered at graduate and undergraduate level due to the successful applications of neural and fuzzy control to nonlinear and unmodeled dynamic systems, including electrical drives. However, teaching students a neurofuzzy controlled electrical drive in a laboratory environment is often difficult for schools with limited access to expensive equipment facilities. Therefore, computer simulations and dedicated software are needed to assist the students in visualizing the concepts and to provide graphical feedback during the learning process. In this article, an educational software is proposed for the neuro-fuzzy control of induction machine drives. The tool helps students learn the application of neuro-fuzzy control of electrical drives. The software has a flexible structure and graphical user interface. The neuro-fuzzy architecture, the motor and load parameters can be easily changed in the developed software. Neuro-fuzzy control performance of induction motors can be monitored graphically for various control structures and current controllers. 2006 Wiley Periodicals, Inc. Comput Appl Eng Educ 14: 211 221, 2006; Published online in Wiley InterScience (www.interscience.wiley.com); DOI 10.1002/cae.20082
A pilot study of the multiherb Kampo medicine bakumondoto for cough in patients with chronic obstructive pulmonary disease.

OBJECTIVES
To evaluate the effect of bakumondoto, Kampo medicine, on cough in patients with chronic obstructive pulmonary disease (COPD).


DESIGN
A 16-week, randomized, open-labeled, cross-over design.


SETTING
Outpatient clinics at one university hospital and two general hospitals in Japan from May 2007 to March 2009.


PARTICIPANTS
Twenty-four elderly patients (14 men and 9 women aged over 65) with COPD.


INTERVENTION
Treatment with or without bakumondoto for 8 weeks in a cross-over design.


MEASUREMENTS
The primary outcome measurements were the frequency and intensity of cough assessed by a visual analogue scale (VAS) and a daily cough diary. Secondary outcome measurements were quality of life (QOL) assessed using St. George's Respiratory Questionnaire (SGRQ) and lung functions measured using spirometry.


RESULTS
Treatment with bakumondoto significantly improved cough severity during the first treatment period (week 0 vs. week 8, p=0.004) and showed a trend to decrease during the second treatment period (week 8 vs. week 16, p=0.129) assessed by the VAS. Neither QOL nor lung function was affected by the treatment with bakumondoto.


CONCLUSION
Bakumondoto may be effective in suppressing cough in elderly patients with COPD. To further confirm the efficacy, a larger and placebo-controlled study with objective cough assessment is necessary.
Antenna Pattern Synthesis Utilizing Spherical Bessel Functions

Pattern synthesis of linear antennas utilizing the spherical bessel functions is presented. This leads to antenna current distribution by the Legendre polynomials of the first kind, which are of finite support. Some examples are given to illustrate this procedure.
Unicellular leneages to understand the origin of metazoan multicellularity: a genomics and cell biology perspective

Trabajo presentado en la BSCB (Britsh Society for Cell Biology) / BSDB (British Society for Developmental Biology) Joint Spring Meeting, celebrada en Coventry del 16 al 19 de marzo de 2014.
Oral bacteria in the occluded arteries of patients with Buerger disease.

OBJECTIVE
Recent studies have suggested that infectious organisms play a role in vascular diseases. In this study, to explore a possible link between oral infection and Buerger disease, we investigated whether oral (periodontal) bacteria were present in occluded arteries removed from patients with characteristic Buerger disease.


METHODS
Fourteen male patients with a smoking history who had developed characteristics of Buerger disease before the age of 50 years were included in this study. Occluded arteries, including superficial femoral (n = 4), popliteal (n = 2), anterior tibial (n = 4), and posterior tibial (n = 4) arteries, were removed and studied. A periodontist performed a periodontal examination on each patient and collected dental plaque and saliva samples from them at the same time. The polymerase chain reaction method was applied to detect whether seven species of periodontal bacteria--Porphyromonas gingivalis, Tannerella forsythensis, Treponema denticola, Campylobacter rectus, Actinobacillus actinomycetemcomitans, Prevotella intermedia , and Prevotella nigrescens--were present in the occluded arteries and oral samples. In addition, arterial specimens from seven control patients were examined by polymerase chain reaction analysis.


RESULTS
DNA of oral bacteria was detected in 13 of 14 arterial samples and all oral samples of patients with Buerger disease. Treponema denticola was found in 12 arterial and all oral samples. Campylobacter rectus, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythensis, and Prevotella nigrescens were found in 14% to 43% of the arterial samples and 71% to 100% of the oral samples. A pathologic examination revealed that arterial specimens showed the characteristics of an intermediate-chronic-stage or chronic-stage lesion of Buerger disease. All 14 patients with Buerger disease had moderate to severe periodontitis. None of the control arterial samples was positive for periodontal bacteria.


CONCLUSIONS
This is the first study to identify oral microorganisms in the lesions of Buerger disease. Our findings suggest a possible etiologic link between Buerger disease and chronic infections such as oral bacterial infections.
Nurses as participants in research: an evaluation of recruitment techniques.

BACKGROUND
Recruitment and retention of participants, as well as response rates, can be challenging in nursing research. This can be because of the questions asked; the choice of methodology; the methods used to collect data; the characteristics of potential participants; the sample size required; and the duration of the study. Additionally, conducting research with nurses as participants presents several issues for them, including the time needed to participate in the research, the competing commitments for clinical practice, the political and environmental climate, and recruitment itself.


AIM
To report on research studies conducted by the authors at a tertiary teaching hospital, to show the lessons learned when recruiting nurses to participate in nursing research.


DISCUSSION
The authors discuss factors that supported recruitment of nurses in these studies, including the use of the personal touch and multiple recruitment strategies in a single study.


CONCLUSION
Videos and photography facilitate interdisciplinary research and can be a valuable means of non-verbal data collection, especially with participants affected by disabilities, and can support research methods, such as the use of questionnaires.


IMPLICATIONS FOR PRACTICE
Recruiting nurses for research can be challenging. We suggest that researchers consider using more than one recruitment strategy when recruiting nurse participants. Recruitment is more successful if researchers align the aim(s) of the research with nurse's concerns and contexts.
Weight loss intervention adherence and factors promoting adherence: a meta-analysis

BACKGROUND
Adhering to weight loss interventions is difficult for many people. The majority of those who are overweight or obese and attempt to lose weight are simply not successful. The objectives of this study were 1) to quantify overall adherence rates for various weight loss interventions and 2) to provide pooled estimates for factors associated with improved adherence to weight loss interventions.


METHODS
We performed a systematic literature review and meta-analysis of all studies published between January 2004 and August 2015 that reviewed weight loss intervention adherence.


RESULTS
After applying inclusion and exclusion criteria and checking the methodological quality, 27 studies were included in the meta-analysis. The overall adherence rate was 60.5% (95% confidence interval [CI] 53.6-67.2). The following three main variables were found to impact adherence: 1) supervised attendance programs had higher adherence rates than those with no supervision (rate ratio [RR] 1.65; 95% CI 1.54-1.77); 2) interventions that offered social support had higher adherence than those without social support (RR 1.29; 95% CI 1.24-1.34); and 3) dietary intervention alone had higher adherence than exercise programs alone (RR 1.27; 95% CI 1.19-1.35).


CONCLUSION
A substantial proportion of people do not adhere to weight loss interventions. Programs supervising attendance, offering social support, and focusing on dietary modification have better adherence than interventions not supervising attendance, not offering social support, and focusing exclusively on exercise.
Metformin versus laparoscopic ovarian drilling in clomiphene- and insulin-resistant women with polycystic ovary syndrome.

OBJECTIVE
To compare the hormonal-metabolic profiles and reproductive outcomes in clomiphene-resistant patients with polycystic ovary syndrome and insulin resistance between women receiving metformin and those undergoing laparoscopic ovarian drilling.


METHODS
A total of 110 eligible participants were randomly allocated to diagnostic laparoscopy plus metformin therapy (group 1, n=55) or laparoscopic ovarian drilling (group 2, n=55). The t test was used for mean comparisons of hormonal-metabolic parameters and OGTT values before and after treatment. The chi(2) test was used for comparisons of ovulation, pregnancy, and abortion rates.


RESULTS
Groups 1 and 2 showed a significant decline in testosterone, insulin-like growth factor-1 (P<0.001 vs P<0.001), and luteinizing hormone (P<0.05 vs P<0.001), while the glucose to insulin ratio was significantly increased (P<0.001 vs P<0.05) compared with baseline. Group 2 patients had more regular cycles and higher rates of ovulation and pregnancy compared with group 1: 76.4% [42/55] vs 58.2% [32/55], P<0.04; 50.8% [131/258] vs 33.5% [94/281], P<0.001; and 38.2% [21/55] vs 20.0% [11/55], P<0.03, respectively. The difference in the early abortion rate between the groups was not statistically significant.


CONCLUSION
Although metformin results in a better attenuation of insulin resistance, laparoscopic ovarian drilling is associated with higher rates of ovulation and pregnancy.
Learning Bayesian networks for clinical time series analysis

INTRODUCTION
Autonomous chronic disease management requires models that are able to interpret time series data from patients. However, construction of such models by means of machine learning requires the availability of costly health-care data, often resulting in small samples. We analysed data from chronic obstructive pulmonary disease (COPD) patients with the goal of constructing a model to predict the occurrence of exacerbation events, i.e., episodes of decreased pulmonary health status.


METHODS
Data from 10 COPD patients, gathered with our home monitoring system, were used for temporal Bayesian network learning, combined with bootstrapping methods for data analysis of small data samples. For comparison a temporal variant of augmented naive Bayes models and a temporal nodes Bayesian network (TNBN) were constructed. The performances of the methods were first tested with synthetic data. Subsequently, different COPD models were compared to each other using an external validation data set.


RESULTS
The model learning methods are capable of finding good predictive models for our COPD data. Model averaging over models based on bootstrap replications is able to find a good balance between true and false positive rates on predicting COPD exacerbation events. Temporal naive Bayes offers an alternative that trades some performance for a reduction in computation time and easier interpretation.
Clinical, radiological, and pathological features of 24 atypical intracranial epidermoid cysts.

OBJECT
Most intracranial epidermoid cysts typically present with long T1 and T2 signals on MR images. Other epidermoid cysts with atypical MR images are often misdiagnosed as other diseases. In this study the authors aimed to analyze the incidence and the clinical, radiological, and pathological features of atypical epidermoid cysts.


METHODS
Among 428 cases of intracranial epidermoid cysts that were surgically treated between 2002 and 2008 at Beijing Tiantan Hospital, cases with an atypical MR imaging appearance were chosen for analysis. Clinical and pathological parameters were recorded and compared in patients with lesions demonstrating typical and atypical MR appearance.


RESULTS
An atypical epidermoid cyst accounts for 5.6% of the whole series. Radiologically, 58.3% of atypical epidermoids were misdiagnosed as other diseases. Compared with a typical epidermoid cyst, atypical epidermoid lesions were significantly larger (p = 0.016, chi-square test). Pathologically, hemorrhage was found in 21 patients with atypical epidermoid cyst and is significantly correlated with granulation (p = 0.010, Fisher exact test). Old hemorrhage was found in 13 cases and was significantly correlated with cholesterol crystals. Twenty-one patients were followed up for 1.3-8.6 years after surgery. The 5- and 8-year survival rates were both 100%. Three patients experienced cyst recurrence. The 5- and 8-year recurrence-free rates were 95% and 81.4%, respectively.


CONCLUSIONS
Radiologically, an atypical epidermoid cyst should be differentiated from dermoid cyst, teratoma, schwannoma, glioma, craniopharyngioma, and cavernous angioma. A tendency toward spontaneous hemorrhage is confirmed in atypical epidermoid cysts, and a hypothesis was proposed for spontaneously intracystic hemorrhage in atypical epidermoid cysts. Follow-up confirmed long-term survival of patients with atypical epidermoid cysts.
Towards a Better Metric for Evaluating Question Generation Systems

There has always been criticism for using ngram based similarity metrics, such as BLEU, NIST, etc, for evaluating the performance of NLG systems. However, these metrics continue to remain popular and are recently being used for evaluating the performance of systems which automatically generate questions from documents, knowledge graphs, images, etc. Given the rising interest in such automatic question generation (AQG) systems, it is important to objectively examine whether these metrics are suitable for this task. In particular, it is important to verify whether such metrics used for evaluating AQG systems focus on answerability of the generated question by preferring questions which contain all relevant information such as question type (Wh-types), entities, relations, etc. In this work, we show that current automatic evaluation metrics based on n-gram similarity do not always correlate well with human judgments about answerability of a question. To alleviate this problem and as a first step towards better evaluation metrics for AQG, we introduce a scoring function to capture answerability and show that when this scoring function is integrated with existing metrics, they correlate significantly better with human judgments. The scripts and data developed as a part of this work are made publicly available.1