LLukas22/scidocs huggingface dataset:
[External multicentric validation of two scores predicting the risk of relapse in patients with borderline ovarian tumors: The nomogram of Bendifallah and the score of Ouldamer].

BACKGROUND
Borderline ovarian tumors are rare and can occur in young women. For these patients, a fertility sparing surgery should be discussed. Two predicting borderline ovarian tumor relapse risk models were developed in 2014 (Nomogram of Bendifallah) and 2017 (Score of Ouldamer). This study aimed to valid in an external population, these two scores using a multi-institutional BOT database.


METHODS
In this bicentric and retrospective study, all consecutive patients comprising the variable nomogram documented treated between January 2006 and December 2012 for BOT in centre hospitalier de Poissy-Saint-Germain and hôpital René-Huguenin were included. A ROC model was established for each predicting scores.


RESULTS
Sixty-five patients were included in the study. Twelve patients showed a recurrence (19%), three of them experienced an infiltrative cancer (5%). The median time of recurrence was 25 months (range: 8-115). The concordance index for the Nomogram of Bendifallah and the Score of Ouldamer were 0.88 (IC 95% [0.78-0.98]) and 0.87 (IC 95% [0.77-0.96]) respectively.


CONCLUSION
This study from an independent population valids the Bendifallah nomogram and Ouldamer score for clinical use in predicting borderline ovarian recurrence.
Combined Therapeutic Effect of Probucol and Cilostazol on Endothelial Function in Patients with Silent Cerebral Lacunar Infarcts and Hypercholesterolemia: A Preliminary Study

OBJECTIVE
This study evaluated the efficacy of combined therapy with probucol and cilostazol on endothelial function in silent lacunar cerebral infarcts (SLCI) and mild hypercholesterolemia.


SUBJECTS AND METHODS
Flow-mediated vasodilatation (FMD) and nitroglycerin-induced vasodilatation (NMD) were measured before and after 4 weeks of combined therapy with probucol (500 mg/day) and cilostazol (200 mg/day) in 34 patients with a mean age of 72 ± 7 years (range 57-80 years) with SLCI, mild hypercholesterolemia (low-density lipoprotein cholesterol >100 mg/dl) and impaired endothelial function (FMD <6%). Patients were randomly allocated to one of the following two treatment groups: (1) aspirin (100 mg/day) with behavioral modifications, such as diet and/or exercise therapy (A group or control group, n = 17), and (2) probucol and cilostazol treatment (PC group, n = 17), also with behavioral modifications.


RESULTS
Although the baseline FMD was not different between the two treatment arms (2.7 ± 1.5 vs. 2.6 ± 1.5%, n.s.), the posttreatment FMD was significantly improved in the PC group (from 2.7 ± 1.5 to 3.5 ± 1.7%, p < 0.05) but not in the A group (from 2.6 ± 1.5 to 2.9 ± 1.4%, n.s.). No differences were observed between baseline and posttreatment NMD in either group. The effects of treatments on lipid profiles were more profound in the PC group.


CONCLUSION
Combined treatment with probucol and cilostazol resulted in subacute improvement in FMD/endothelial function in patients with SLCI with mild hypercholesterolemia. This combination therapy has the potential to reduce the risk of cardiovascular events via improvements in endothelial function and lipid profiles.
Using Videotape As a Supplement to Traditional Student Teacher Supervision.

MFOI/PC01 Plus Postage. Evaluation Methods; Feedback; Higher Education; Preservice Teacher Education; Program Development; Program Implementation; Secondary Education; Self Evaluation (Individuals); *Student Teachers; Student Teaching; *Supervisory Methods; *Teacher Evaluation; Teacher Role; *Teacher Supervision; *Videotape Recordings Studies have found that the more familiar student teachers are with competency-based assessment measures and the more exposure they have to self-assessment and assessment by supervising teachers and professors, the more competent they will be in class. Programs that involve videotaping student teachers have been found to be effective assessment strategies. Various studies and programs have been conducted in which videotape recordings of teaching behaviors of student teachers are produced as part of a self-assessment or evaluation by other educators. In one example, student teachers videotaped themselves as they taught and then mailed the videotapes to a faculty supervisory team on a university campus; the team viewed the tapes and initiated conference calls to the student teachers and their cooperating teachers to provide feedback. In another study, students felt that optimum learning occurred when the student teacher and the supervisor viewed the tape together and discussed the evaluation in the context of the lesson being watched. One obstacle to program effectiveness may be the discomfort student teachers experience when learning to use new technology such as camcorders. The roles of the supervisor, the cooperating teacher, and the student teacher in utilizing videotaping as a supplemental supervisory tool are clarified. (IDD) *********************************************************************** Reproductions supplied by EDRS are the best that can be made from the original document. ***********************************************************************
Arsenic exposure to drinking water in the Mekong Delta.

Arsenic (As) contamination of groundwater drinking sources was investigated in the Mekong Delta, Vietnam in order to assess the occurrence of As in the groundwater, and the magnitude of As exposure of local residents through measurements of As in toenails of residents consuming groundwater as their major drinking water source. Groundwater (n=68) and toenail (n=62) samples were collected in Dong Thap Province, adjacent to the Mekong River, in southern Vietnam. Fifty-three percent (n=36) of the wells tested had As content above the World Health Organization's (WHO) recommended limit of 10 ppb. Samples were divided into Northern (mean As=4.0 ppb) and Southern (329.0 ppb) groups; wells from the Southern group were located closer to the Mekong River. Elevated As contents were associated with depth (<200 m), salinity (low salinity), and redox state (reducing conditions) of the study groundwater. In 79% of the wells, As was primarily composed of the reduced As(III) species. Arsenic content in nails collected from local residents was significantly correlated to As in drinking water (r=0.49, p<0.001), and the relationship improved for pairs in which As in drinking water was higher than 1 ppb (r=0.56, p<0.001). Survey data show that the ratio of As in nail to As in water varied among residents, reflecting differential As bioaccumulation in specific exposed sub-populations. The data show that water filtration and diet, particularly increased consumption of animal protein and dairy, and reduced consumption of seafood, were associated with lower ratios of As in nail to As in water and thus could play important roles in mitigating As exposure in areas where As-rich groundwater is the primary drinking water source.
Combining frequency-difference and ultrasound modulated electrical impedance tomography

Electrical impedance tomography (EIT) is highly affected by modeling errors regarding electrode positions and the shape of the imaging domain. In this work, we propose a new inclusion detection technique that is completely independent of such errors. Our new approach is based on a combination of frequency-difference and ultrasound modulated EIT measurements. AMS classification scheme numbers: 35R30, 35J25
The relationship among receptive and expressive vocabulary, listening comprehension, pre-reading skills, word identification skills, and reading comprehension by children with reading disabilities.

PURPOSE
Some researchers (F. R. Vellutino, F. M. Scanlon, & M. S. Tanzman, 1994) have argued that the different domains comprising language (e.g., phonology, semantics, and grammar) may influence reading development in a differential manner and at different developmental periods. The purpose of this study was to examine proposed causal relationships among different linguistic subsystems and different measures of reading achievement in a group of children with reading disabilities.


METHODS
Participants were 279 students in 2nd to 3rd grade who met research criteria for reading disability. Of those students, 108 were girls and 171 were boys. In terms of heritage, 135 were African and 144 were Caucasian. Measures assessing pre-reading skills, word identification, reading comprehension, and general oral language skills were administered.


RESULTS
Structural equation modeling analyses indicated receptive and expressive vocabulary knowledge was independently related to pre-reading skills. Additionally, expressive vocabulary knowledge and listening comprehension skills were found to be independently related to word identification abilities.


CONCLUSION
Results are consistent with previous research indicating that oral language skills are related to reading achievement (e.g., A. Olofsson & J. Niedersoe, 1999; H. S. Scarborough, 1990). Results from this study suggest that receptive and expressive vocabulary knowledge influence pre-reading skills in differential ways. Further, results suggest that expressive vocabulary knowledge and listening comprehension skills facilitate word identification skills.
A Comparative Study of Student Engagement, Satisfaction, and Academic Success among International and American Students.

Higher education is becoming increasingly globalized and internationalized, and the number of international students studying in U.S. institutions of higher education is continuously growing. International students contribute to their own success, campus diversity, campus internationalization, and the U.S. economy. However, it is not merely enough to bring international students—it is critical to serve them, retain them, and graduate them. Programs and services that stimulate international student engagement in educationally purposeful activities are crucial. Student engagement in effective educational practices is associated with high levels of learning and personal development. While student engagement has been studied extensively for American students, this is not the case for international students. The purpose of this study was to examine the relationship between student engagement and student satisfaction and the academic success of international and American students using 2008 National Survey of Student Engagement (NSSE) data. Specifically, it investigated how institutional type (classification and control) and critical mass (percentage of international students and academic major) affect student engagement (represented by five NSSE benchmarks) and how student engagement affects student satisfaction and academic success. In addition, this study compared student engagement of international and American students. This study is significant for research by informing the audience about the extent to which international students are satisfied with their experiences, how they interact with peers and faculty, and how they participate in educational activities. It contributes to policy by informing institutions how funds should be allocated toward particular effective educational practices and to practice by informing administrators, faculty, and staff about
A web-based self-help intervention for partners of cancer patients based on Acceptance and Commitment Therapy: a protocol of a randomized controlled trial

BACKGROUND
There is a growing recognition that cancer not only affects the lives of the patients, but also the lives of their partners. Partners of cancer patients are highly involved in the illness trajectory by providing informal care and they often experience distress. However, supporting interventions for this group are scarce and existing interventions bear several limitations. On the basis of the need for theory- and evidence-based supportive interventions for partners of cancer patients, the web-based self-help intervention Hold on, for each other has been developed. This intervention is based on Acceptance and Commitment Therapy. The primary objective of the RCT is to investigate the (cost-) effectiveness of the intervention. Additional goals are (1) to examine if psychological flexibility, self-compassion, mastery, supportive behavior, posttraumatic growth and resilience are mediators of the intervention's effects on the partners' mental health; (2) to examine the moderating effects of the socio demographics (age, gender, education, working situation, family situation) and disease-related characteristics of the patients (sort of cancer, stage of disease, duration and treatment of cancer); and (3) to investigate to what extend participants are satisfied with the intervention, which parts of the intervention are mostly used, and how adherent the users are.


METHODS/DESIGN
A three-armed randomized controlled trial (RCT) will be conducted to compare two versions of the intervention Hold on, for each other with a waiting list control condition. Both intervention conditions contain the same content and differ only with regard to the form of professional support (personal support versus automatic support). Adult partners of cancer patients with mild to moderate depressive and anxiety symptoms, will be recruited through a multi-component strategy. Online measurements by self-assessment will be made on four measurement points (prior to randomization (baseline-measurement) and 3, 6 and 12 months after baseline).


DISCUSSION
When proven effective, Hold on, for each other can be an invaluable contribution to the healthcare system and it could be offered to all partners of cancer patients who are in need for additional support.


TRIAL REGISTRATION
Dutch Trial Register, trial registration number NTR4035, date of registration: 17 March 2013.
Population pharmacokinetics of lamotrigine in Chinese children with epilepsy

Aim:To establish a population pharmacokinetics (PPK) model for lamotrigine (LTG) in Chinese children with epilepsy in order to formulate an individualized dosage guideline.Methods:LTG steady-state plasma concentration data from therapeutic drug monitoring (TDM) were collected retrospectively from 284 patients, with a total of 404 plasma drug concentrations. LTG concentrations were determined using a HPLC method. The patients were divided into 2 groups: PPK model group (n=116) and PPK valid group (n=168). A PPK model of LTG was established with NONMEM based on the data from PPK model group according to a one-compartment model with first order absorption and elimination. To validate the basic and final model, the plasma drug concentrations of the patients in PPK model group and PPK valid group were predicted by the two models.Results:The final regression model for LTG was as follows: CL (L/h)=1.01*(TBW/27.87)0.635*e−0.753*VPA*e0.868*CBZ*e0.633*PB, Vd (L)= 16.7*(TBW/27.87). The final PPK model was demonstrated to be stable and effective in the prediction of serum LTG concentrations by an internal and external approach validation.Conclusion:A PPK model of LTG in Chinese children with epilepsy was successfully established with NONMEM. LTG concentrations can be predicted accurately by this model. The model may be very useful for establishing initial LTG dosage guidelines.
THE BIOLOGIC BASIS OF TRANSGENDER IDENTITY: 2D:4D FINGER LENGTH RATIOS IMPLICATE A ROLE FOR PRENATAL ANDROGEN ACTIVITY.

OBJECTIVE
The biologic basis for gender identity is unknown. Research has shown that the ratio of the length of the second and fourth digits (2D:4D) in mammals is influenced by biologic sex in utero, but data on 2D:4D ratios in transgender individuals are scarce and contradictory. We investigated a possible association between 2D:4D ratio and gender identity in our transgender clinic population in Albany, New York.


METHODS
We prospectively recruited 118 transgender subjects undergoing hormonal therapy (50 female to male [FTM] and 68 male to female [MTF]) for finger length measurement. The control group consisted of 37 cisgender volunteers (18 females, 19 males). The length of the second and fourth digits were measured using digital calipers. The 2D:4D ratios were calculated and analyzed with unpaired t tests.


RESULTS
FTM subjects had a smaller dominant hand 2D:4D ratio (0.983 ± 0.027) compared to cisgender female controls (0.998 ± 0.021, P = .029), but a ratio similar to control males (0.972 ± 0.036, P =.19). There was no difference in the 2D:4D ratio of MTF subjects (0.978 ± 0.029) compared to cisgender male controls (0.972 ± 0.036, P = .434).


CONCLUSION
Our findings are consistent with a biologic basis for transgender identity and the possibilities that FTM gender identity is affected by prenatal androgen activity but that MTF transgender identity has a different basis.


ABBREVIATIONS
2D:4D = 2nd digit to 4th digit; FTM = female to male; MTF = male to female.
A prospective, randomized, double‐blind, multicentre, parallel‐group, active controlled study to compare efficacy and safety of biosimilar adalimumab (Exemptia; ZRC‐3197) and adalimumab (Humira) in patients with rheumatoid arthritis

AIM
In this study, efficacy, tolerability and safety of biosimilar adalimumab (Exemptia; Zydus Cadila) was compared with reference adalimumab (Humira; AbbVie) in patients with moderate to severe rheumatoid arthritis (RA).


METHOD
In this multicentre, prospective, randomized, double-blind, active controlled parallel arm study, 120 patients with moderate to severe RA were given 40 mg of either test adalimumab (Exemptia) or reference adalimumab (Humira) by subcutaneous route every other week for 12 weeks. The primary endpoint was proportion of responders in two tretament groups by American College of Rheumatology 20 (ACR20) at week 12. The secondary endpoints were change in Disease Activity Score of 28 joints - C-reactive protein (DAS28-CRP) and proportion of patients with an ACR50 and ACR70 response in two treatment groups at week 12. Safety outcomes were also assessed.


RESULTS
After 12 weeks, patients treated every other week with test adalimumab (Zydus Cadila) had statistically similar response rates as compared to reference adalimumab (AbbVie): ACR20 (82% vs. 79.2%; P > 0.7); ACR50 (46%, vs. 43.4%; P > 0.7); ACR70 (14% vs. 15.1%; P > 0.8). The change in DAS28-CRP score was -2.1 ± 1.09 and -2.1 ± 1.21, in test and reference products, respectively. It was statistically significant compared to baseline, but not significantly different between the two products. Three serious adverse events and no death was reported during the study. Both adalimumab preparations were safe and well tolerated in this study.


CONCLUSION
The results demonstrated biosimilarity with respect to efficacy, tolerability and safety of test adalimumab (Exemptia) and reference adalimumab (Humira) in patients with moderate to severe RA.
The Role of Conspiracist Ideation and Worldviews in Predicting Rejection of Science

BACKGROUND
Among American Conservatives, but not Liberals, trust in science has been declining since the 1970's. Climate science has become particularly polarized, with Conservatives being more likely than Liberals to reject the notion that greenhouse gas emissions are warming the globe. Conversely, opposition to genetically-modified (GM) foods and vaccinations is often ascribed to the political Left although reliable data are lacking. There are also growing indications that rejection of science is suffused by conspiracist ideation, that is the general tendency to endorse conspiracy theories including the specific beliefs that inconvenient scientific findings constitute a "hoax."


METHODOLOGY/PRINCIPAL FINDINGS
We conducted a propensity weighted internet-panel survey of the U.S. population and show that conservatism and free-market worldview strongly predict rejection of climate science, in contrast to their weaker and opposing effects on acceptance of vaccinations. The two worldview variables do not predict opposition to GM. Conspiracist ideation, by contrast, predicts rejection of all three scientific propositions, albeit to greatly varying extents. Greater endorsement of a diverse set of conspiracy theories predicts opposition to GM foods, vaccinations, and climate science.


CONCLUSIONS
Free-market worldviews are an important predictor of the rejection of scientific findings that have potential regulatory implications, such as climate science, but not necessarily of other scientific issues. Conspiracist ideation, by contrast, is associated with the rejection of all scientific propositions tested. We highlight the manifold cognitive reasons why conspiracist ideation would stand in opposition to the scientific method. The involvement of conspiracist ideation in the rejection of science has implications for science communicators.
Incidence of primary central nervous system germ cell tumors in childhood: a regional survey in Kumamoto prefecture in southern Japan.

BACKGROUND/AIMS
Central nervous system germ cell tumors (CNS-GCTs) are relatively rare. While their incidence was thought to be higher in East Asia than the USA, recent evidence suggests the difference between Japan and the USA is not statistically significant. The aim of this study was to determine the rate of pediatric primary CNS-GCTs in Kumamoto prefecture, Japan.


METHODS
We surveyed 6,615 new cases of primary intracranial tumors diagnosed in Kumamoto prefecture between 1989 and 2011. Among these, 251 (3.8%) occurred in patients younger than 15 years. The age-adjusted incidence rates were calculated by the direct method using 5-year age groupings; the incidence in the total Japanese population in the year 2000 was the standard.


RESULTS
During the 23-year period, 70 cases of primary GCT were diagnosed. Of these tumors, 31 (44.3%) arose in patients aged between 0 and 14 years (22 boys, 9 girls). Their tumor location was pineal in 45.2%; the other sites were nonpineal. There were more germinomas (64.5%) than nongerminomas (35.5%) in this group. The age-adjusted annual incidence rate was 0.45 cases (boys: 0.64, girls: 0.28) per 10(5) children. At 2.29, the ratio of CNS-GCTs was higher in these boys than girls. Our data showed higher rates than data from CBTRUS 2012 (0.18/10(5)), SEER 2008 (0.15/10(5)) and Germany (0.10/10(5)).


CONCLUSIONS
Our survey showed that the incidence of primary CNS-GCTs in children was higher in Kumamoto prefecture than in the USA and other Western countries, suggesting that racial backgrounds play a role.
Virtual Rehabilitation Environment Using Principles of Intrinsic Motivation and Game Design

This paper presents a novel multimodal virtual rehabilitation environment. Its design and implementation are based on principles related to intrinsic motivation and game design. The system consists of visual, acoustic, and haptic modalities. Elements contributing to intrinsic motivation are carefully joined in the three modalities to increase patients' motivation during the long process of rehabilitation. The message in a bottle (MIB) virtual scenario is designed to allow interplay between motor and cognitive challenges in the exercising patient. The user first needs to perform a motor action to receive a cognitive challenge that is finally solved by a second motor action. Visual feedback provides the most relevant information related to the task. Acoustic feedback consists of environmental sounds, music, and spoken instructions or encouraging statements for the patient. The haptic modality generates tactile information related to the environment and provides various modes of assistance for the patient's arm movements. The MIB scenario was evaluated with 16 stroke patients, who rated it positively using the Intrinsic Motivation Inventory questionnaire. Additionally, the MIB scenario seems to elicit higher motivation than a simpler pick-and-place training task.