LLukas22/scidocs huggingface dataset:
PHYTO-PHARMACOLOGY of Berberis aristata DC: A REVIEW

Mazumder Papiya Mitra , *Das Saumya , Das Sanjita , Das Manas Kumar 3 Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi, India-835215 2* Department of Pharmaceutical Technology, Noida Institute of Engineering & Technology, Greater Noida, India-201306 Department of Pharmacy, IEC-CET, Greater Noida, India-201306 Corresponding author’s Email: awasthi_saumya22@rediffmail.com, Ph: 0091-9911756080, 0091-9911940620
Technical and management notes: Professional training for the engineer-manager (don't forget the “engineering”)

Engineering management is perhaps the most common career path for the successful engineer. In designing curricula to provide for the training of engineer-managers, engineering schools need to be responsive to the needs of the community and the individual engineer. These needs are best served by a program of study that addresses both the management needs and the engineering needs of the engineer-manager.
Triangulation in practice

Triangulation is the means by which an alternate perspective is used to validate, challenge or extend existing findings. It is frequently used when the field of study is difficult, demanding or contentious and presence research meets all of these criteria. We distinguish between the use of hard and soft triangulation—the former emphasising the challenging of findings, the latter being more confirmatory in character. Having reviewed a substantial number of presence papers, we conclude that strong triangulation is not widely used while soft triangulation is routinely employed. We demonstrate the usefulness of hard triangulation by contrasting an ontological analysis of in-ness with an empirical study of (computer) game playing. We conclude that presence research would be well served by the wider use of hard triangulation and for the reporting of anomalous and ill-fitting results.
Direct Torque Control of Doubly Star Induction Motor Using Fuzzy Logic Speed Controller

Received Nov 26, 2017 Revised Jan 22, 2018 Accepted Feb 25, 2018 This paper presents the simulation of the control of doubly star induction motor using Direct Torque Control (DTC) based on Proportional and Integral controller (PI) and Fuzzy Logic Controller (FLC). In addition, the work describes a model of doubly star induction motor in α-β reference frame theory and its computer simulation in MATLAB/SIMULINK®.The structure of the DTC has several advantages such as the short sampling time required by the TC schemes makes them suited to a very fast flux and torque controlled drives as well as the simplicity of the control algorithm.the generalpurpose induction drives in very wide range using DTC because it is the excellent solution. The performances of the DTC with a PI controller and FLC are tested under differents speeds command values and load torque. Keyword:
A Randomized, Double-Blind, Double-Dummy Study to Evaluate the Intranasal Human Abuse Potential and Pharmacokinetics of a Novel Extended-Release Abuse-Deterrent Formulation of Oxycodone

OBJECTIVE
Evaluate the human abuse potential (HAP) of an experimental, microsphere-in-capsule formulation of extended-release oxycodone (oxycodone DETERx®) (herein "DETERx").


DESIGN
Randomized, double-blind, double-dummy, positive- and placebo-controlled, single-dose, four-phase, four-treatment, crossover study.


SETTING
Clinical research site.


SUBJECTS
There were 39 qualifying subjects (72% male, 85% white, mean age of 27 years) with 36 completing all four Double-blind Treatment Periods.


METHODS
The four phases encompassed: 1) Screening; 2) Drug Discrimination; 3) Double-blind Treatment; and 4) Follow-up. Drug Discrimination tests ensured that subjects could distinguish placebo from opioid. The four Double-blind Treatments compared DETERx-administered as either a crushed intranasal (IN) or an intact oral (PO) preparation-with immediate-release oxycodone IN (OXY-IR IN) and with an intact IN and PO placebo DETERx control.


RESULTS
For primary pharmacokinetic (PK) assessments, abuse quotient (Cmax/Tmax) was lower with DETERx IN than DETERx PO; both treatments were substantially lower than OXY-IR IN (6.24, 8.60, and 69.6 ng/mL/h, respectively). For drug liking, the primary subjective pharmacodynamic (PD) endpoint, both DETERx IN and DETERx PO produced significantly lower scores than OXY-IR IN (P ≤ 0.0001 for each); DETERx IN was less liked than DETERx PO (P ≤ 0.05), mirroring the PK relationships. Objectively assessed pupillometry corroborated the more rapid and significantly greater effect of OXY-IR IN than either DETERx IN or DETERx PO (P ≤ 0.007 for each). Overall safety profiles of DETERx and OXY-IR were comparable and both were well tolerated.


CONCLUSIONS
Pharmacokinetic and pharmacodynamic outcomes suggest that DETERx IN has relatively low HAP; continued research in larger populations is suggested.
Genetic and environmental influences on the prospective correlation between systemic inflammation and coronary heart disease death in male twins.

OBJECTIVE
Because of lack of evidence, we aimed to examine to what degree low-grade systemic inflammation and coronary heart disease (CHD) death shared common genetic and environmental substrates.


APPROACH AND RESULTS
From the 41-year prospective National Heart, Lung, and Blood Institute Twin Study, we included 950 middle-aged male twins at baseline (1969-1973). Low-grade systemic inflammation was measured with plasma levels of interleukin-6 (IL-6) and C-reactive protein. Univariate and bivariate structural equation models were used, adjusted for a risk score for CHD death. The score-adjusted heritability was 19% for IL-6, 27% for C-reactive protein, and 22% for CHD death. The positive phenotypic correlation of IL-6 with CHD death (radjusted=0.27; 95% confidence interval [CI], 0.08-0.43) was driven by additive genetic factors (contribution [relative contribution], 0.30 [111%]) but attenuated by unique environment (-0.03 [-11%]). The genetic correlation between IL-6 and CHD death was 0.74 (95% CI, 0.21-1.00), whereas the unique environmental correlation was -0.05 (95% CI, -0.35 to 0.25). The proportion of genetic variance for CHD death shared with that for IL-6 was 74%. The phenotypic correlation of C-reactive protein with CHD death (radjusted=0.10; 95% CI, -0.02 to 0.22) was explained by additive genetic factors (0.20 [149%]) but was attenuated by the unique environment (-0.09 [-49%]). The genetic correlation of C-reactive protein with CHD death was 0.63 (95% CI, -0.07 to 1.00), whereas the unique environmental correlation was -0.07 (95% CI, -0.29 to 0.17).


CONCLUSIONS
Low-grade systemic inflammation, measured by IL-6, and long-term CHD death share moderate genetic substrates that augment both traits.
Paradoxical effects of testing: repeated retrieval attempts enhance the likelihood of later accurate and false recall.

The testing effect is the finding that taking an initial test enhances the likelihood of later recall. The present report examines the extent to which this benefit of testing comes with a cost: an enhanced likelihood of erroneously recalling incorrect information. Subjects were given short lists of semantic associates (e.g., hill, valley, climb); each list converged upon a related nonpresented word (e.g., mountain). After presentation of some lists, the subjects received no initial test; after others, one initial free recall test; and after others, three successive free recall tests. The probabilities of final free recall (and the probability of reporting vivid recollection of the moment of encoding) of both studied and related, nonstudied words (e.g., mountain) were highest when three initial tests had been taken, intermediate following one initial test, and lowest when no initial test had occurred. The beneficial effects of testing carry the cost of increases in erroneous memory for related information.
Metformin: An Old Drug for the Treatment of Diabetes but a New Drug for the Protection of the Endothelium

The anti-diabetic and oral hypoglycaemic agent metformin, first used clinically in 1958, is today the first choice or 'gold standard' drug for the treatment of type 2 diabetes and polycystic ovary disease. Of particular importance for the treatment of diabetes, metformin affords protection against diabetes-induced vascular disease. In addition, retrospective analyses suggest that treatment with metformin provides therapeutic benefits to patients with several forms of cancer. Despite almost 60 years of clinical use, the precise cellular mode(s) of action of metformin remains controversial. A direct or indirect role of adenosine monophosphate (AMP)-activated protein kinase (AMPK), the fuel gauge of the cell, has been inferred in many studies, with evidence that activation of AMPK may result from a mild inhibitory effect of metformin on mitochondrial complex 1, which in turn would raise AMP and activate AMPK. Discrepancies, however, between the concentrations of metformin used in in vitro studies versus therapeutic levels suggest that caution should be applied before extending inferences derived from cell-based studies to therapeutic benefits seen in patients. Conceivably, the effects, or some of them, may be at least partially independent of AMPK and/or mitochondrial respiration and reflect a direct effect of either metformin or a minor and, as yet, unidentified putative metabolite of metformin on a target protein(s)/signalling cascade. In this review, we critically evaluate the data from studies that have investigated the pharmacokinetic properties and the cellular and clinical basis for the oral hypoglycaemic, insulin-sensitising and vascular protective effects of metformin.
Convergent-beam electron diffraction of CaZr4O9, a complex zirconia alloy phase

Abstract The point-group and space-group symmetry of the controversial fluorite-based stoichiometric superlath phase of o 1 (CaZr 4 O 9 : Z=16), considered to be a coherently-intergrown subphase of lime-stabilized zirconia, is examined. Using convergent-beam and selected-area electron diffraction, it is determined that the space group of o 1 is C2/ c , in apparent agreement with earlier studies utilizing other diffraction techniques.
An adaptive image Euclidean distance

Article history: Received 13 October 2007 Received in revised form 12 June 2008 Accepted 31 July 2008
Body size, physical activity, and risk of triple-negative and estrogen receptor-positive breast cancer.

BACKGROUND
Triple-negative breast cancer, characterized by a lack of hormone receptor and HER2 expression, is associated with a particularly poor prognosis. Focusing on potentially modifiable breast cancer risk factors, we examined the relationship between body size, physical activity, and triple-negative disease risk.


METHODS
Using data from 155,723 women enrolled in the Women's Health Initiative (median follow-up, 7.9 years), we assessed associations between baseline body mass index (BMI), BMI in earlier adulthood, waist and hip circumference, waist-hip ratio, recreational physical activity, and risk of triple-negative (n=307) and estrogen receptor-positive (ER+, n=2,610) breast cancers.


RESULTS
Women in the highest versus lowest BMI quartile had 1.35-fold (95% CI, 0.92-1.99) and 1.39-fold (95% CI, 1.22-1.58) increased risks of triple-negative and ER+ breast cancers, respectively. Waist and hip circumferences were positively associated with risk of ER+ breast cancer (Ptrend=0.01 for both measures) but were not associated with triple-negative breast cancer. Compared with women who reported no recreational physical activity, women in the highest activity tertile had similarly lower risks of triple-negative and ER+ breast cancers (HR=0.77; 95% CI, 0.51-1.13; and HR=0.85; 95% CI, 0.74-0.98, respectively).


CONCLUSIONS
Despite biological and clinical differences, triple-negative and ER+ breast cancers are similarly associated with BMI and recreational physical activity in postmenopausal women. The biological mechanisms underlying these similarities are uncertain and these modest associations require further investigation.


IMPACT
If confirmed, these results suggest potential ways postmenopausal women might modify their risk of both ER+ and triple-negative breast cancers.
YETI on the Cloud

The York Extensible Testing Infrastructure (YETI) is an automated random testing tool that allows to test programs written in various programming languages. While YETI is one of the fastest random testing tools with over a million method calls per minute on fast code, testing large programs or slow code -- such as libraries using intensively the memory -- might benefit from parallel executions of testing sessions. This paper presents the cloud-enabled version of YETI. It relies on the Hadoop package and its map/reduce implementation to distribute tasks over potentially many computers. This would allow to distribute the cloud version of YETI over Amazon's Elastic Compute Cloud (EC2).
Parsing Indoor Scenes Using RGB-D Imagery

This paper presents an approach to parsing the Manhattan structure of an indoor scene from a single RGBD frame. The problem of recovering the floor plan is recast as an optimal labeling problem which can be solved efficiently using Dynamic Programming.
Full-Body MRI in Patients With an Implantable Cardioverter-Defibrillator: Primary Results of a Randomized Study.

BACKGROUND
Magnetic resonance imaging (MRI) of patients with conventional implantable cardioverter-defibrillators (ICD) is contraindicated.


OBJECTIVES
This multicenter, randomized trial evaluated safety and efficacy of a novel ICD system specially designed for full-body MRI without restrictions on heart rate or pacing dependency. The primary safety objective was >90% freedom from MRI-related events composite endpoint within 30 days post-MRI. The primary efficacy endpoints were ventricular pacing capture threshold and ventricular sensing amplitude.


METHODS
Subjects received either a single- or dual-chamber ICD. In a 2:1 randomization, subjects either underwent MRI at 1.5-T of the chest, cervical, and head regions to maximize radiofrequency exposure up to 2 W/kg specific absorption rate and gradient field exposure to 200 T/m/s per axis (MRI group, n = 175), or they underwent a 1-h waiting period without MRI (control group, n = 88). A subset of MRI patients underwent ventricular fibrillation induction testing post-MRI to characterize defibrillation function.


RESULTS
In 42 centers, 275 patients were enrolled (76% male, age 60.4 ± 13.8 years). The safety endpoint was met with 100% freedom from the composite endpoint (p < 0.0001). Both efficacy endpoints were met with minimal differences in the proportion of MRI and control patients who demonstrated a ≤0.5 V increase in ventricular pacing capture threshold (100% MRI vs. 98.8% control, noninferiority p < 0.0001) or a ≤50% decrease in R-wave amplitude (99.3% MRI vs. 98.8% control, noninferiority p = 0.0001). A total of 34 ventricular tachyarrhythmia/ventricular fibrillation episodes (20 induced; 14 spontaneous) occurred in 24 subjects post-MRI, with no observed effect on sensing, detection, or treatment.


CONCLUSIONS
This is the first randomized clinical study of an ICD system designed for full-body MRI at 1.5-T. These data support that the system is safe and the MRI scan does not adversely affect electrical performance or efficacy. (Confirmatory Clinical Trial of the Evera MRI System for Conditionally-Safe MRI Access; NCT02117414).
Knowledge management modeling in public sector organizations : a case study

Purpose – The purpose of this paper is to describe the successful use of a knowledge management (KM) model in a public sector organization. Design/methodology/approach – Building on the theoretical foundation of others, this case study demonstrates the value of KM modeling in a science-based initiative in the Canadian public service. Findings – The Inukshuk KM model, which comprises the five elements of technology, leadership, culture, measurement, and process, provides a holistic approach in public service KM. Practical implications – The proposed model can be employed by other initiatives to facilitate KM planning and implementation. Originality/value – This the first project to consider how KM models may be implemented in a Canadian public service environment.
Evaluation of the safety, pharmacodynamic, and pharmacokinetic effects following oral coadministration of immediate-release morphine with ethanol in healthy male participants.

OBJECTIVE
This paper aimed to evaluate the effects of coadministered immediate-release morphine and ethanol on safety, pharmacokinetic, and pharmacodynamic measures.


METHODS
In the first stage of a randomized, double-blind, placebo-controlled, crossover study, 16 healthy men with a history of moderate drinking received morphine 50 mg+ethanol 0.7 g/kg, morphine 50 mg+ethanol placebo, and morphine placebo+ethanol 0.7 g/kg. In the second stage, participants received either a lower (30 mg) or higher (80 mg) morphine dose (alone and in combination with ethanol) depending on their tolerability to treatments in stage 1. Safety, pharmacodynamic (including visual analog scales, pupillometry, capnography, and psychomotor and cognitive measures), and pharmacokinetic assessments were conducted.


RESULTS
With the exception of one severe adverse event (AE), all others were mild or moderate in intensity. Morphine resulted in dose-related increases in AEs. When morphine was administered with ethanol, similar AEs were observed (dizziness, headache, somnolence, nausea, and vomiting), but these were sometimes more frequent compared with those observed with either drug alone. No consistent additive or interaction effects were observed on pharmacodynamic measures. Ethanol had no apparent effects on the pharmacokinetics of morphine or its metabolites.


CONCLUSIONS
Coadministration of single doses of morphine and ethanol tested in this study did not affect the safety, pharmacodynamics, or pharmacokinetics of morphine or ethanol administered alone. Copyright © 2014 John Wiley & Sons, Ltd.
A Practical Dynamic Buffer Overflow Detector

Despite previous efforts in auditing software manually and automatically, buffer overruns are still being discovered in programs in use. A dynamic bounds checker detects buffer overruns in erroneous software before it occurs and thereby prevents attacks from corrupting the integrity of the system. Dynamic buffer overrun detectors have not been adopted widely because they either (1) cannot guard against all buffer overrun attacks, (2) break existing code, or (3) incur too high an overhead. This paper presents a practical detector called CRED (C Range Error Detector) that avoids each of these deficiencies. CRED finds all buffer overrun attacks as it directly checks for the bounds of memory accesses. Unlike the original referent-object based bounds-checking technique, CRED does not break existing code because it uses a novel solution to support program manipulation of out-of-bounds addresses. Finally, by restricting the bounds checks to strings in a program, CRED’s overhead is greatly reduced without sacrificing protection in the experiments we performed. CRED is implemented as an extension of the GNU C compiler version 3.3.1. The simplicity of our design makes possible a robust implementation that has been tested on over 20 open-source programs, comprising over 1.2 million lines of C code. CRED proved effective in detecting buffer overrun attacks on programs with known vulnerabilities, and is the only tool found to guard against a testbed of 20 different buffer overflow attacks[34]. Finding overruns only on strings impose an overhead of less This research was performed while the first author was at Stanford University, and this material is based upon work supported in part by the National Science Foundation under Grant No. 0086160. than 26% for 14 of the programs, and an overhead of up to 130% for the remaining six, while the previous state-ofthe-art bounds checker by Jones and Kelly breaks 60% of the programs and is 12 times slower. Incorporating wellknown techniques for optimizing bounds checking into CRED could lead to further performance improvements.
THE LYAPUNOV AND DIMENSION SPECTRA OF EQUILIBRIUMMEASURES FOR CONFORMAL EXPANDING MAPS

In this note, we nd an explicit relationship between the dimension spectrum for equilibrium measures and the Lyapunov spectrum for conformal repellers. We explicitly compute the Lyapunov spectrum and show that it is a delta function. We observe that while the Lyapunov exponent exists for almost every point with respect to an ergodic measure, the set of points for which the Lyapunov exponent does not exist has positive Hausdorr dimension if the SRB measure does not coincide with the measure of maximal entropy. It follows that for such conformal repellers, the set of points for which the pointwise dimension of the measure of maximal entropy does not exist has positive Hausdorr dimension. In EP], Eckmann and Procaccia suggested an analysis of the spectrum of Lyapunov exponents for chaotic dynamical systems which is similar to the multifractal analysis of measures invariant under chaotic dynamical systems. This suggestion was further investigated on a physical level by Sz epfalusy and T el ST] and by T el T]. In this note, we nd an explicit relationship between the dimension spectrum for equilibrium measures (see Appendix) and the Lyapunov spectrum for conformal expanding maps. We also explicitly compute the Lyapunov spectrum and show that it is a delta function. Using the multifractal analysis of equilibrium measures for conformal repellers in PW1], we show that while the Lyapunov exponent exists for almost every point with respect to an ergodic measure, the set of points for which the Lyapunov exponent does not exist has positive Hausdorr dimension if the SRB measure (Sinai-Ruelle-Bowen) B] does not coincide with the measure of maximal entropy. It follows that for such conformal repellers, the set of points for which the pointwise dimension of the measure of maximal entropy does not exist has positive Hausdorr dimension. The dimension spectrum is one of the principle components in the multifractal analysis of measures. In PW1] the authors eeected a complete multifractal analysis of equilibrium measures for conformal expanding maps. Examples of conformal expanding maps include Markov one-dimensional maps, rational maps whose Julia sets are hyperbolic, and conformal endomorphisms of the torus. See PW1] for deenitions and examples. Let M be a smooth manifold and g : M ! M a C 2 map. Suppose that is a compact invariant subset of M and consider the map g restricted to. We say that g is a conformal
Matching resumes and jobs based on relevance models

We investigate the difficult problem of matching semi-structured resumes and jobs in a large scale real-world collection. We compare standard approaches to Structured Relevance Models (SRM), an extensionof relevance-based language model for modeling and retrieving semi-structured documents. Preliminary experiments show that the SRM approach achieved promising performance and performed better than typical unstructured relevance models.