LLukas22/scidocs huggingface dataset:
Effect of repeated dietary counseling on serum lipoproteins from infancy to adulthood.

BACKGROUND AND OBJECTIVE
As atherosclerosis is a lifelong process, prevention of exposure to its risk factors should start at an early age. Our aim was to study the influences of repeated low saturated fat dietary counseling on dietary intakes and lipoprotein measures from infancy to adulthood.


METHODS
Dietary intakes (food records) and serum lipid profile were studied annually from 7 months to 19 years of age in an atherosclerosis prevention study (Special Turku Coronary Risk Factor Intervention Project), comprising 540 children in the intervention group and 522 children in the control group. Serum total and high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG) were measured and used to estimate very low-density lipoprotein-TG, intermediate-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and HDL(2)-C, as well as apolipoproteins A-1 and B.


RESULTS
Compared with controls, the intervention children had a lower saturated fat intake (mean daily difference [95% confidence interval] between groups: -2.1 [-2.3, -1.9] percentage of total energy intake in boys; -1.9 [-2.1, -1.7] percentage of total energy intake in girls, both P < .001) and LDL-C concentration (difference [95% confidence interval] between groups: -0.18 [-0.26, -0.10] mmol/L, P < .001 in boys; -0.10 [-0.19, -0.01] mmol/L, P = .037 in girls), whereas HDL-C and apolipoprotein A-1 did not differ between the study groups. In boys, total cholesterol and intermediate-density lipoprotein cholesterol, very low-density lipoprotein-TG, apolipoprotein B, and TG concentrations were also lower in the intervention than in the control group, whereas no differences were found in girls.


CONCLUSIONS
Repeated dietary counseling is effective in decreasing saturated fat intake and serum LDL-C values from infancy until 19 years of age in both genders. In boys, significant intervention effects are evident in various lipoprotein measures, indicating a more favorable lipid profile in the counseling group.
Subchondral bone remodeling is related to clinical improvement after joint distraction in the treatment of ankle osteoarthritis.

OBJECTIVE
In osteoarthritis (OA), subchondral bone changes alter the joint's mechanical environment and potentially influence progression of cartilage degeneration. Joint distraction as a treatment for OA has been shown to provide pain relief and functional improvement through mechanisms that are not well understood. This study evaluated whether subchondral bone remodeling was associated with clinical improvement in OA patients treated with joint distraction.


METHOD
Twenty-six patients with advanced post-traumatic ankle OA were treated with joint distraction for 3 months using an Ilizarov frame in a referral center. Primary outcome measure was bone density change analyzed on computed tomography (CT) scans. Longitudinal, manually segmented CT datasets for a given patient were brought into a common spatial alignment. Changes in bone density (Hounsfield Units (HU), relative to baseline) were calculated at the weight-bearing region, extending subchondrally to a depth of 8mm. Clinical outcome was assessed using the ankle OA scale.


RESULTS
Baseline scans demonstrated subchondral sclerosis with local cysts. At 1 and 2 years of follow-up, an overall decrease in bone density (-23% and -21%, respectively) was observed. Interestingly, density in originally low-density (cystic) areas increased. Joint distraction resulted in a decrease in pain (from 60 to 35, scale of 100) and functional deficit (from 67 to 36). Improvements in clinical outcomes were best correlated with disappearance of low-density (cystic) areas (r=0.69).


CONCLUSIONS
Treatment of advanced post-traumatic ankle OA with 3 months of joint distraction resulted in bone density normalization that was associated with clinical improvement.
Academia and ordinance [My First Job]

George W. Zobrist, an associate editor with IEEE Potentials, looks back at his 50-year career.
FairAccess: a new Blockchain-based access control framework for the Internet of Things

Security and privacy are huge challenges in Internet of Things (IoT) environments, but unfortunately, the harmonization of the IoT-related standards and protocols is hardly and slowly widespread. In this paper, we propose a new framework for access control in IoT based on the blockchain technology. Our first contribution consists in providing a reference model for our proposed framework within the Objectives, Models, Architecture and Mechanism specification in IoT. In addition, we introduce FairAccess as a fully decentralized pseudonymous and privacy preserving authorization management framework that enables users to own and control their data. To implement our model, we use and adapt the blockchain into a decentralized access control manager. Unlike financial bitcoin transactions, FairAccess introduces new types of transactions that are used to grant, get, delegate, and revoke access. As a proof of concept, we establish an initial implementation with a Raspberry PI device and local blockchain. Finally, we discuss some limitations and propose further opportunities. Copyright © 2017 John Wiley & Sons, Ltd.
The utility of tumour markers in assessing the response to chemotherapy in advanced bladder cancer

In patients with advanced bladder cancer receiving chemotherapy, early assessment of response can avoid unnecessary toxicity. The aim of this study was to assess the role of tumour markers in monitoring response. Serum levels of one or more of markers β human chorionic gonadotrophin (βhCG), carcinoembryomic antigen (CEA), CA125 and CA19.9 were measured in 74 patients with advanced bladder cancer receiving chemotherapy from 1992 to 1997. Forty-three of 74 (58%) of patients had at least one raised marker (1.5 times upper limit of normal range). This was more common in patients with extra-pelvic disease than in those with disease confined to the pelvis (P= 0.002). Thirty-eight of 78 (49%) assessable patients had a radiological response. Neither clinical response (P= 0.81) nor survival (P= 0.16) differed between marker-negative and marker-positive patients. Clinical response was strongly related to marker response in the 35 comparable patients (P= 0.0001). No patient had a clinical response without response of at least one marker. Ninety per cent of patients who achieved a marker response had done so by 8 weeks. Monitoring of tumour markers in patients with advanced bladder cancer can help predict the response to chemotherapy. © 2000 Cancer Research Campaign
Mathematical modeling of the capacity fade of Li-ion cells

A capacity fade prediction model has been developed for Li-ion cells based on a semi-empirical approach. Correlations for variation of capacity fade parameters with cycling were obtained with two different approaches. The first approach takes into account only the active material loss, while the second approach includes rate capability losses too. Both methods use correlations for variation of the film resistance with cycling. The state of charge (SOC) of the limiting electrode accounts for the active material loss. The diffusion coefficient of the limiting electrode was the parameter to account for the rate capability losses during cycling. © 2003 Elsevier Science B.V. All rights reserved.
Effects of the chromanol 293 B , a selective blocker of the slow , component of the delayed rectifier K q current , on repolarization in human and guinea pig ventricular myocytes

q Ž . Objectives: The slow component of the delayed rectifier K current I is believed to be important in cardiac repolarization, and Ks may be a potential target for antiarrhythmic drugs, but its study has been limited by a lack of specific blockers. The chromanol derivate 293B blocks currents expressed by minK and not HERG in Xenopus oocytes, but little is known about its effects on native currents and action potentials. We aimed to establish the effects of 293B on K, Na and Ca currents and action potentials in human and guinea pig cardiomyocytes. Methods: Whole-cell patch clamp techniques were applied to assess the effects of 293B on isolated myocytes at Ž . 368C. Results: Delayed rectifier current I elicited by pulses to q60 mV from a holding potential of y50 mV in guinea pig myocytes K Ž . was strongly inhibited by 293B maximum inhibition 96.9"0.8%; 50% inhibitory concentration, EC , 1.02 mM , but I during pulses 50 K Ž . to y10 mV was unaffected 3.9"8.4% inhibition at 50 mM . Half-activation voltages, current-voltage relations, and current densities of drug-resistant and drug-sensitive I correspond to those of I and I respectively. Inward rectifier K current, Na current and L-type K Kr Ks Ca current were unaffected by 293B. Transient outward current in human ventricular myocytes was inhibited by 293B at an EC of 24 50 mM, less than one twentieth the potency for I inhibition in guinea pig myocytes. While dofetilide prolonged action potential duration Ks Ž . APD with strong reverse use dependence, 293B prolonged guinea pig and human ventricular APD to a similar fractional extent at all frequencies. Conclusions: 293B is a selective I blocker, and the frequency dependence of APD prolongation caused by this I blocker Ks Ks is different from that caused by I blockade: 293B may be an interesting tool to study the physiologic role of I and the antiarrhythmic Kr Ks potential of I blockade. q 1998 Elsevier Science B.V. All rights reserved. Ks
Referrals for bowel ultrasound in clinical practice: a survey in 12 nationwide centres in Italy.

BACKGROUND
The value of ultrasound (US) in assessing gastrointestinal diseases is well documented, but its demand in clinical practice is unknown. This survey evaluated the demand for bowel US in Italy.


METHODS
Twelve sonographers of the Gastroenterology Section of the Italian Society of Ultrasound participated in a 1-month survey; they compiled a questionnaire assessing total number of patients referred for abdominal US and for gastrointestinal tract US, type of referring physician, indications and results of examinations.


RESULTS
The survey included 2424 examinations, 586 of which (24%) investigated the gastrointestinal tract: 280 for signs or symptoms and 268 for follow-up of pre-existing gastrointestinal diseases. Referring physicians were mainly gastroenterologists (78%) and general practitioners (13%). Organic lesions were found or suspected in 292 examinations.


CONCLUSIONS
Bowel US is used in Italy in routine practice, mainly by gastroenterologists and general practitioners, both for follow-up of pre-existing diseases and for gastrointestinal complaints.
High efficiency Ka-band power amplifier MMICs fabricated with a 0.15µm GaN on SiC HEMT process

The design and performance of two high efficiency Ka-band power amplifier MMICs utilizing a 0.15µm GaN HEMT process technology is presented. Measured in-fixture continuous wave (CW) results for the 3-stage amplifiers demonstrates 8–9W of output power for the balanced MMIC and 4.5–6W for the single-ended configuration. The associated power added (PAE) efficiency of both amplifiers exceeds 25% at Ka-band. The die sizes for the balanced and single-ended MMICs are 2.55×3.80mm<sup>2</sup> and 1.39×3.42mm<sup>2</sup> respectively.
The effectiveness of manual stretching in the treatment of plantar heel pain: a systematic review

BACKGROUND
Plantar heel pain is a commonly occurring foot complaint. Stretching is frequently utilised as a treatment, yet a systematic review focusing only on its effectiveness has not been published. This review aimed to assess the effectiveness of stretching on pain and function in people with plantar heel pain.


METHODS
Medline, EMBASE, CINAHL, AMED, and The Cochrane Library were searched from inception to July 2010. Studies fulfilling the inclusion criteria were independently assessed, and their quality evaluated using the modified PEDro scale.


RESULTS
Six studies including 365 symptomatic participants were included. Two compared stretching with a control, one study compared stretching to an alternative intervention, one study compared stretching to both alternative and control interventions, and two compared different stretching techniques and durations. Quality rating on the modified Pedro scale varied from two to eight out of a maximum of ten points. The methodologies and interventions varied significantly between studies, making meta-analysis inappropriate. Most participants improved over the course of the studies, but when stretching was compared to alternative or control interventions, the changes only reached statistical significance in one study that used a combination of calf muscle stretches and plantar fascia stretches in their stretching programme. Another study comparing different stretching techniques, showed a statistically significant reduction in some aspects of pain in favour of plantar fascia stretching over calf stretches in the short term.


CONCLUSIONS
There were too few studies to assess whether stretching is effective compared to control or other interventions, for either pain or function. However, there is some evidence that plantar fascia stretching may be more effective than Achilles tendon stretching alone in the short-term. Appropriately powered randomised controlled trials, utilizing validated outcome measures, blinded assessors and long-term follow up are needed to assess the efficacy of stretching.
Patient Navigation and Time to Diagnostic Resolution: Results for a Cluster Randomized Trial Evaluating the Efficacy of Patient Navigation among Patients with Breast Cancer Screening Abnormalities, Tampa, FL

OBJECTIVES
The objective of this study was to evaluate a patient navigation (PN) program that attempts to reduce the time between a breast cancer screening abnormality and definitive diagnosis among medically underserved populations of Tampa Bay, Florida.


METHODS
The Moffitt Patient Navigation Research Program conducted a cluster randomized design with 10 primary care clinics. Patients were navigated from time of a breast screening abnormality to diagnostic resolution. This paper examined the length of time between breast abnormality and definitive diagnosis, using a shared frailty Cox proportional hazard model to assess PN program effect.


RESULTS
1,039 patients were eligible for the study because of an abnormal breast cancer screening/clinical abnormality (494 navigated; 545 control). Analysis of PN effect by two time periods of resolution (0-3 months and > 3 months) showed a lagged effect of PN. For patients resolving in the first three months, the adjusted Hazard Ratio (aHR) was 0.85 (95% Confidence Interval [CI]: 0.64-1.13) suggesting that PN had no effect on resolution time during this period. Beyond three months, however, navigated patients resolved more quickly to diagnostic resolution compared with the control group (aHR 2.8, 95%CI: 1.30-6.13). The predicted aHR at 3 months was 1.2, which was not statistically significant, while PN had a significant positive effect beyond 4.7 months.


CONCLUSIONS
PN programs may increase the timeliness of diagnostic resolution for patients with a breast cancer-related abnormality. PN did not speed diagnostic resolution during the initial three months of follow up but started to reduce time to diagnostic resolution after three months and showed a significant effect after 4.7 months.


TRIAL REGISTRATION
ClinicalTrials.gov NCT00375024.
The VCDQ--a Questionnaire for symptom monitoring in vocal cord dysfunction.

BACKGROUND
Vocal cord dysfunction (VCD) typically involves abnormal adduction of the vocal cords during inspiration, mimics the symptoms of asthma and leads to the prescription of ineffective medications.


OBJECTIVE
We aimed to develop a clinical tool to monitor symptoms and response to treatment in confirmed VCD.


METHODS
We collated symptoms of VCD from focus groups comprising patients and healthcare professionals; phrases describing these symptoms were assessed for face validity and internal correlation and rated for importance. The resultant 12-item questionnaire (VCDQ) rated the impact of each on a 5-point Likert scale (total score range 12-60) and was tested for reliability, concurrent validity and performance in 31 patients with endoscopically confirmed VCD (± asthma), 29 asthmatics with no history of VCD and 14 healthy controls. We assessed response to speech and language therapy and the minimal important difference by measuring the VCDQ pre- and post- therapy in a 20 new patients.


RESULTS
The VCDQ had excellent test-retest reliability and differentiated VCD vs. healthy (Mann-Whitney U-test: z = -5.390, P < 0.001) and asthma (z = -5.730, P < 0.001). All patients improved post-therapy, assessed both by a global rating of change score (GRCS) and by the VCDQ [median (IQR) score pre-therapy 50.5 (48.0 - 54.8), post-therapy 35.0 (29.3 - 41.8), P < 0.001]. The minimal important difference in the VCDQ associated with a rating of 'minimally better' on the GRCS was 4 points.


CONCLUSIONS AND CLINICAL RELEVANCE
The VCDQ is a valid and responsive tool suitable for measuring changes in symptoms in patients with VCD. It also gives insight into which symptoms are important to patients and could guide future therapy refinements. Future assessments of novel therapies for this condition should use an appropriately validated tool such as the VCDQ to measure response.
Estimating the current and future costs of Type 1 and Type 2 diabetes in the UK, including direct health costs and indirect societal and productivity costs.

AIMS
To estimate the current and future economic burdens of Type 1 and Type 2 diabetes in the UK.


METHODS
A top-down approach was used to estimate costs for 2010/2011 from aggregated data sets and literature. Prevalence and population data were used to project costs for 2035/2036. Direct health costs were estimated from data on diagnosis, lifestyle interventions, ongoing treatment and management, and complications. Indirect costs were estimated from data on mortality, sickness, presenteeism (potential loss of productivity among people who remain in work) and informal care.


RESULTS
Diabetes cost approximately £ 23.7bn in the UK in 2010/2011: £ 9.8bn in direct costs (£1bn for Type 1 diabetes and £ 8.8bn for Type 2 diabetes) and £ 13.9bn in indirect costs (£ 0.9bn and £ 13bn). In real terms, the 2035/2036 cost is estimated at £ 39.8bn: £ 16.9bn in direct costs (£ 1.8bn for Type 1 diabetes and £ 15.1bn for Type 2 diabetes) and £ 22.9bn in indirect costs (£ 2.4bn and £ 20.5bn). Sensitivity analysis applied to the direct costs produced a range of costs: between £ 7.9bn and £ 11.7bn in 2010/2011 and between £ 13.8bn and £20bn in 2035/2036. Diabetes currently accounts for approximately 10% of the total health resource expenditure and is projected to account for around 17% in 2035/2036.


CONCLUSIONS
Type 1 and Type 2 diabetes are prominent diseases in the UK and are a significant economic burden. Data differentiating between the costs of Type 1 and Type 2 diabetes are sparse. Complications related to the diseases account for a substantial proportion of the direct health costs. As prevalence increases, the cost of treating complications will grow if current care regimes are maintained.
Triazolam and zolpidem: effects on human memory and attentional processes

Rationale: The imidazopyridine hypnotic zolpidem may produce less memory and cognitive impairment than classic benzodiazepines, due to its relatively low binding affinity for the benzodiazepine receptor subtypes found in areas of the brain which are involved in learning and memory. Objectives: The study was designed to compare the acute effects of single oral doses of zolpidem (5, 10, 20 mg/70 kg) and the benzodiazepine hypnotic triazolam (0.125, 0.25, and 0.5 mg/70 kg) on specific memory and attentional processes. Methods: Drug effects on memory for target (i.e., focal) information and contextual information (i.e., peripheral details surrounding a target stimulus presentation) were evaluated using a source monitoring paradigm, and drug effects on selective attention mechanisms were evaluated using a negative priming paradigm, in 18 healthy volunteers in a double-blind, placebo-controlled, crossover design. Results: Triazolam and zolpidem produced strikingly similar dose-related effects on memory for target information. Both triazolam and zolpidem impaired subjects’ ability to remember whether a word stimulus had been presented to them on the computer screen or whether they had been asked to generate the stimulus based on an antonym cue (memory for the origin of a stimulus, which is one type of contextual information). The results suggested that triazolam, but not zolpidem, impaired memory for the screen location of picture stimuli (spatial contextual information). Although both triazolam and zolpidem increased overall reaction time in the negative priming task, only triazolam increased the magnitude of negative priming relative to placebo. Conclusions: The observed differences between triazolam and zolpidem have implications for the cognitive and pharmacological mechanisms underlying drug-induced deficits in specific memory and attentional processes, as well for the cognitive and brain mechanisms underlying these processes.
Fragmentation or cohesion? Visualizing the process and consequences of information system diversity, 1993-2012

Received: 27 October 2014 Revised: 29 December 2015 Accepted: 12 January 2016 Abstract In information systems (IS) literature, there is ongoing debate as to whether the field has become fragmented and lost its identity in response to the rapid changes of the field. The paper contributes to this discussion by providing quantitative measurement of the fragmentation or cohesiveness level of the field. A co-word analysis approach aiding in visualization of the intellectual map of IS is applied through application of clustering analysis, network maps, strategic diagram techniques, and graph theory for a collection of 47,467 keywords from 9551 articles, published in 10 major IS journals and the proceedings of two leading IS conferences over a span of 20 years, 1993 through 2012. The study identified the popular, core, and bridging topics of IS research for the periods 1993–2002 and 2003–2012. Its results show that research topics and subfields underwent substantial change between those two periods and the field became more concrete and cohesive, increasing in density. Findings from this study suggest that the evolution of the research topics and themes in the IS field should be seen as part of the natural metabolism of the field, rather than a process of fragmentation or disintegration. European Journal of Information Systems advance online publication, 22 March 2016; doi:10.1057/ejis.2016.5
Towards an Enterprise Architecture for Public Administration using a Top-Down Approach

The use of Enterprise Architectures is becoming increasingly widespread in the private sector. Borrowing insights from enterprise reference architectures developed during the last decade, IT vendors and companies belonging to specific industries are establishing reference data and process models advancing the standardization of their businesses and creating a more integrated environment for their activities. Although public administrations share the same problem of non-standardization, which is being magnified rapidly in a changing and demanding environment, little has been done so far in the direction of integration. This article builds a basis, shows initial directions and attempts to stimulate interest in a PA enterprise framework. Following a top-down approach and employing concepts from the fields of public administration, enterprise integration and generic process and data modeling the outline of the ArchPad enterprise architecture for Public Administration is presented.