LLukas22/scidocs huggingface dataset:
Further defining the language impairment of autism: is there a specific language impairment subtype?

UNLABELLED
Some children with autism demonstrate poor nonword repetition--a deficit considered to be a psycholinguistic marker of specific language impairment (SLI). The present study examined whether there is an SLI subtype among children with autism. We compared the language abilities of children with SLI (n=34, M age=11;10 S.D.=2;3), and children with autism with (Apoor, n=18, M age=10;11 S.D.=3;1) and without (Aapp, n=16, M age=10;8 S.D.=2;7) structural language difficulties. Participants were administered battery of standardized language and memory tests. Although there were some similarities in the language profile of the SLI and Apoor groups, the two groups differed on the tests of oromotor ability and verbal short-term memory and showed a different pattern of errors on the nonword repetition task. These findings providing evidence against the idea of an SLI subtype in autism. Further analyses suggested that the nonword repetition deficits experienced by some children with autism may arise when there is substantial impairment in multiple autistic domains.


LEARNING OUTCOMES
Readers will be introduced to (a) the current state of behavioral, cognitive and genetic research that has investigated the relation between SLI and autism, and (b) three hypotheses of why there exists similarity in the language characteristics of children with SLI and autism. Readers will then be taken through a detailed comparison of the language and memory abilities of group of children with each diagnosis. A theoretical model that seeks to explain the relation between these two disorders will be discussed.
Subgradient Methods for Saddle-Point Problems

We study subgradient methods for computing the saddle points of a convex-concave function. Our motivation is coming from networking applications where dual and primaldual subgradient methods have attracted much attention in designing decentralized network protocols. We first present a subgradient algorithm for generating approximate saddle points and provide per-iteration convergence rate estimates on the constructed solutions. We then focus on Lagrangian duality, where we consider a convex primal optimization problem and its Lagrangian dual problem, and generate approximate primaldual optimal solutions as approximate saddle points of the Lagrangian function. We present a variation of our subgradient method under the Slater constraint qualification and provide stronger estimates on the convergence rate of the generated primal sequences. In particular, we provide bounds on the amount of feasibility violation and on the primal objective function values at the approximate solutions. Our algorithm is particularly well-suited for problems where the subgradient of the dual function cannot be evaluated easily (equivalently, the minimum of the Lagrangian function at a dual solution cannot be computed efficiently), thus impeding the use of dual subgradient methods.
Effect of maternal glycemia on neonatal adiposity in a multiethnic Asian birth cohort.

CONTEXT
Gestational hyperglycemia increases the risk of obesity and diabetes in offspring later in life.


OBJECTIVE
We examined the relationship between gestational glycemia and neonatal adiposity in a multiethnic cohort of Singaporean neonates.


DESIGN
A prospective mother-offspring cohort study recruited 1247 pregnant mothers (57.2% Chinese, 25.5% Malay, 17.3% Indian) and performed 75-g, 2-hour oral glucose tolerance tests at 26-28 weeks' gestation; glucose levels were available for 1081 participants. Neonatal anthropometry (birth weight, length, triceps, and subscapular skinfolds) was measured, and percentage body fat (%BF) was derived using our published equation. Associations of maternal glucose with excessive neonatal adiposity [large for gestational age; %BF; and sum of skinfolds (∑SFT)>90th centile] were assessed using multiple logistic regression analyses.


RESULTS
Adjusting for potential confounders we observed strong positive continuous associations across the range of maternal fasting and 2-hour glucose in relation to excessive neonatal adiposity; each 1 SD increase in fasting glucose was associated with 1.31 [95% confidence interval (CI) 1.10-1.55], 1.72 (95% CI 1.31-2.27) and 1.64 (95% CI 1.32-2.03) increases in odds ratios for large for gestational age and %BF and ∑SFT greater than the 90th centile, respectively. Corresponding odds ratios for 2-hour glucose were 1.11 (95% CI 0.92-1.33), 1.55 (95% CI 1.10-2.20), and 1.40 (95% CI 1.10-1.79), respectively. The influence of high maternal fasting glucose on neonatal ∑SFT was less pronounced in Indians compared with Chinese (interaction P=.005).


CONCLUSIONS
A continuous relationship between maternal glycemia and excessive neonatal adiposity extends across the range of maternal glycemia. Compared with Chinese infants, Indian infants may be less susceptible to excessive adiposity from high maternal glucose levels.
Yoga leads to multiple physical improvements after stroke, a pilot study.

OBJECTIVE
To assess change in physical functioning (pain, range of motion (ROM), strength, and endurance) after 8 weeks of therapeutic-yoga.


DESIGN
Planned analyses of data from a randomized pilot study of yoga after stroke.


SETTING
University-based research laboratory.


PARTICIPANTS
People with chronic stroke (N=47) randomized to therapeutic-yoga (n=37) or wait-list control (n=10).


INTERVENTIONS
16 sessions of therapeutic yoga (twice a week/8 weeks). Yoga was delivered in a standardized and progressive format with postures, breathing, and meditation, and relaxation in sitting, standing, and supine.


MAIN MEASURES
Pain was assessed with the PEG, a 3-item functional measure of the interference of pain. ROM included neck and hip active and passive ROM measurements). Upper and lower extremity strength were assessed with the arm curl test and chair-to-stand test, respectively. Endurance was assessed with the 6-minute walk and modified 2-min step test.


RESULTS
After a Bonferroni Correction, pain, neck ROM, hip passive ROM, upper extremity strength, and the 6-min walk scores all significantly improved after 8 weeks of engaging in yoga. No changes occurred in the wait-list control group.


CONCLUSIONS
A group therapeutic-yoga intervention may improve multiple aspects of physical functioning after stroke. Such an intervention may be complementary to traditional rehabilitation.
Management of injuries to the anterior cruciate ligament: results of a survey of orthopaedic surgeons in Canada.

OBJECTIVE
To identify the approaches to management of anterior cruciate ligament (ACL) injury by Canadian orthopedic surgeons.


METHODS
A questionnaire was mailed to 234 physicians randomly chosen from the Canadian Orthopaedic Association directory to obtain the following information: 1) how orthopaedic surgeons diagnose acute hemarthroses; 2) how patients in any of three common ACL injury scenarios would be managed; 3) what variations exist in surgical technique; and 4) how patient variables such as age, gender, and alignment influence the decision-making process.


RESULTS
The return rate was 72%, and 56% of respondents were from academic centers. Patients such as those described in the protocol are routinely managed by 80% of the respondents. The diagnosis of acute hemarthrosis is predominantly made by means of clinical examination and radiographs. Magnetic resonance imaging (MRI) is used occasionally by 43% and routinely by 6% of those who responded; arthroscopy is used routinely by 24%. For the competitive athlete with a complete ACL tear, 64% would recommend reconstruction and 33% would recommend bracing and rehabilitation. For reconstruction, 59% would use bone-patellar tendon-bone (B-PT-B) autograft and 32% would use hamstring tendon autograft; 40% would incorporate the ACL stump during reconstruction. Of the respondents, 77% would advocate ACL reconstruction for competitive athletes with chronic ACL injury. Of these, 63% would use B-PT-B autograft and 27% would use hamstring tendons. If bracing and rehabilitation failed, 98% would recommend ACL reconstruction. In ACL reconstruction, synthetic augmentation would be used by 12% in chronic cases and by 16% in acute cases. In making the decision to perform ACL reconstruction, 53% consider limb alignment to be important and 67% consider moderate patellofemoral pain to be important. Seventy-one percent are influenced by patellofemoral pain when choosing a surgical technique, with a trend toward semitendinosis autograft rather than B-PT-B autograft reconstruction. For the 8-year-old child with an acute ACL injury, 63% of the respondents would recommend rehabilitation and bracing. For the 14-year-old, 45% would recommend rehabilitation and bracing and 37% would recommend ACL reconstruction after physeal closure.


CONCLUSION
The results of the survey indicate that, with respect to some of the issues, there is a wide variation in management of acute and chronic ACL injuries among Canadian orthopedic surgeons. Future research and randomized, controlled clinical trials should be directed toward these areas.
Does a GLP-1 receptor agonist change glucose tolerance in patients treated with antipsychotic medications? Design of a randomised, double-blinded, placebo-controlled clinical trial

BACKGROUND
Metabolic disturbances, obesity and life-shortening cardiovascular morbidity are major clinical problems among patients with antipsychotic treatment. Especially two of the most efficacious antipsychotics, clozapine and olanzapine, cause weight gain and metabolic disturbances. Additionally, patients with schizophrenia-spectrum disorders not infrequently consume alcohol. Glucagon-like peptide-1 (GLP-1) has shown to improve glycaemic control and reduce alcohol intake among patients with type 2 diabetes.


OBJECTIVES
To investigate whether the beneficial effects of GLP-1 analogues on glycaemic control and alcohol intake, in patients with type 2 diabetes, can be extended to a population of pre-diabetic psychiatric patients receiving antipsychotic treatment.


METHODS AND ANALYSIS
Trial design, intervention and participants: The study is a 16-week, double-blinded, randomised, parallel-group, placebo-controlled clinical trial, designed to evaluate the effects of the GLP-1 analogue liraglutide on glycaemic control and alcohol intake compared to placebo in patients who are prediabetic, overweight (body mass index ≥27 kg/m(2)), diagnosed with a schizophrenia-spectrum disorder and on stable treatment with either clozapine or olanzapine.


OUTCOMES
The primary endpoint is the change in glucose tolerance from baseline (measured by area under the curve for the plasma glucose excursion following a 4 h 75 g oral glucose tolerance test) to follow-up at week 16. The secondary endpoints include changes of dysglycaemia, body weight, waist circumference, blood pressure, secretion of incretin hormones, insulin sensitivity and β cell function, dual-energy X-ray absorption scan (body composition), lipid profile, liver function and measures of quality of life, daily functioning, severity of the psychiatric disease and alcohol consumption from baseline to follow-up at week 16. Status: Currently recruiting patients.


ETHICS AND DISSEMINATION
Ethical approval has been obtained. Before screening, all patients will be provided oral and written information about the trial. The study will be disseminated by peer-review publications and conference presentations.


TRIAL REGISTRATION NUMBER
ClinicalTrials.gov: NCT01845259, EudraCT: 2013-000121-31.
Monetary Policy Rules Based on Real-Time Data

This paper examines the magnitude of informational problems associated with the implementation and interpretation of simple monetary policy rules. Using Taylor’s rule as an example, I demonstrate that real-time policy recommendations differ considerably from those obtained with ex post revised data. Further, estimated policy reaction functions based on ex post revised data provide misleading descriptions of historical policy and obscure the behavior suggested by information available to the Federal Reserve in real time. These results indicate that reliance on the information actually available to policy makers in real time is essential for the analysis of monetary policy rules. (JEL E52, E58)
DRIVERS' PERCEPTIONS OF HEADLIGHT GLARE FROM ONCOMING AND FOLLOWING VEHICLES

Safety Administration, in the interest of information exchange. The opinions, findings and conclusions expressed in this publication are those of the author(s) and not necessarily those of the Department of Transportation or the National Highway Traffic Safety Administration. The United States Government assumes no liability for its contents or use thereof. If trade or manufacturers' names are mentioned, it is only because they are considered essential to the object of the publication and should not be construed as an endorsement. The United States Government does not endorse products or manufacturers. Recently, U.S. drivers have been expressing concern over the discomfort and reduced visibility that they experience from headlight glare from other vehicles. Drivers have focused their concern on the relatively new high intensity discharge lights, high mounted lights, and various auxiliary lights. In order to better understand this glare problem, the National Highway Traffic Safety Administration collected data on drivers' perception of glare from a representative sample of U.S. drivers. The survey was conducted through Omnibus Survey of the Bureau of Transportation Statistics. The present study is based on the information (data) collected on two types of glare: glare from oncoming and following vehicles. The survey data were analyzed to find out how U.S. drivers perceive the two types of glare and if glare perception is associated with respondents' age and gender. Contingency analysis was conducted to establish these associations. The statistics showed that a sizeable number of respondents feel that glare was 'disturbing'. The percent frequency distributions were used to better understand the age and gender profiles of drivers who felt disturbed by the nighttime glare. It was found that the age group 35 to 44 had the highest percentage of night drivers as well as among those who felt glare 'disturbing'. In addition, female respondents of this age group were more of the opinion that the glare from oncoming and following vehicles was 'disturbing' as compared with other age groups of their own gender or even of the opposite gender.
A Genetic Algorithm for Solving RSA Problem in Elastic Optical Networks with Dedicated Path Protection

In this work we address the problem of static Routing and Spectrum Assignment (RSA) in a flexible grid optical network with dedicated path protection consideration. Since RSA is a difficult problem, we make use of the Genetic Algorithm (GA) metaheuristic to provide nearoptimal solutions to the problem. We investigate the effectiveness of GA for a set of network scenarios. Evaluation results show that the proposed algorithm outperforms reference algorithms from the literature. 1
Novel Corrosion Inhibitor for Mild Steel in HCl

Corrosion inhibitory effects of new synthesized compound namely 5,5'- ((1Z,1'Z)-(1,4-phenylenebis(methanylylidene))bis(azanylylidene))bis(1,3,4-thiadiazole-2-thiol) (PBB) on mild steel in 1.0 M HCl was investigated at different temperatures using open circuit potential (OCP), potentiodynamic polarization (PDP) and electrochemical impedance spectroscopy (EIS). Results showed that PBB inhibited mild steel corrosion in acid solution and indicated that the inhibition efficiencies increased with the concentration of inhibitor, but decreased proportionally with temperature. Changes in impedance parameters suggested the adsorption of PBB on the mild steel surface, leading to the formation of protective films.
Dental erosion. Definition, classification and links.

An overview of tooth wear, i.e. of non-carious destructive processes affecting the teeth including abrasion, demastication, attrition, abfraction, resorption and erosion is presented. The nomenclature and classification of dental erosion commonly used in the dental literature are summarized. They are based on etiology (extrinsic, intrinsic, idiopathic), on clinical severity (Classes I to III), on pathogenetic activity (manifest, latent) or on localization (perimolysis). Interactions between erosion and abrasion, demastication, attrition, and abfraction as well as caries and low salivary flow rate are highlighted.
Neuropsychological functioning in children with Tourette syndrome with and without attention-deficit/hyperactivity disorder.

OBJECTIVE
Neuropsychological functioning in children with Tourette syndrome (TS) has been characterized by subtle deficits in response inhibition, visual-motor integration, and fine-motor coordination. The association of these deficits with the tics of the TS versus co-occurring attention-deficit/hyperactivity disorder (ADHD) has not been well understood because of small sample sizes and lack of adequate control conditions. We examined neuropsychological functioning in relatively large and well-characterized samples of children categorized as TS, TS-plus-ADHD, ADHD, and unaffected controls.


METHOD
A total of 56 children with TS-only, 45 with TS-plus-ADHD, 64 with ADHD, and 71 healthy community control subjects were assessed on a battery of neuropsychological measures including the Connors' Continuous Performance Test (CPT), the Stroop Color-Word Interference Test (Stroop), the Beery Visual-Motor Integration Test (VMI), and the Purdue Pegboard Test.


RESULTS
There were no differences between children with TS-only and unaffected controls on the measures of response inhibition and visual-motor integration. Boys with TS-only but not girls with TS-only were impaired in the dominant hand Purdue performance. Children with ADHD were impaired on all study measures. Children with TS-plus-ADHD revealed no deficits on the Stroop, VMI, and Purdue tests but were impaired on the sustained attention portion of the CPT.


CONCLUSIONS
These results indicate that co-occurring ADHD may be responsible for the neuropsychological deficits, or at least those assessed in the present study, in children with TS. Explanations in terms of neurobiological mechanisms of co-occurring TS and ADHD, as well as possible compensatory mechanisms in children with TS, are discussed.
Asymmetry of Inframammary Folds in Patients Undergoing Augmentation Mammaplasty.

BACKGROUND
Variation in the anatomical position of the inframammary fold (IMF) in women remains poorly studied.


OBJECTIVES
The purpose of this study was to evaluate the incidence of asymmetry between IMF locations on the chest wall of women undergoing breast augmentation and to determine breast measurements associated with IMF asymmetry.


METHODS
Three-dimensional imaging analysis of the breasts was performed in 111 women with micromastia, using the Vectra Imaging System(TM). The following measurements were recorded: vertical distance between right and left IMF (inter-fold distance), vertical distance between nipples (inter-nipple distance), and difference between projection of right and left breasts in anterior-posterior direction.


RESULTS
Asymmetry between the right and left IMF positions was found in the majority of patients (95.4%), with symmetry only found in 5 patients (4.6%). In the majority of patients (60.3%), the right IMF was located inferior to the left IMF with median inter-fold distance 0.4 cm (range, 0.1, 2.1 cm). In 39 patients (35.1%), the left IMF was located inferior to the right with median inter-fold distance 0.4 cm (range, 0.1, 1.7 cm). There was strong correlation between the degree of asymmetry of IMF and asymmetry of nipple areola complex (NAC) positions (r = 0.687, P < .01).


CONCLUSIONS
The majority of women with micromastia demonstrate asymmetry of the IMF, which correlates with asymmetry of NAC location. The authors propose a classification system based on most commonly observed IMF locations as types I (right IMF inferior to left), type II (left IMF inferior to right) and type III (both IMF located on the same level). LEVEL OF EVIDENCE 4: Diagnostic.
Emotional conflict occurs at an early stage: Evidence from the emotional face–word Stroop task

The perceptual processing of emotional conflict was studied using electrophysiological techniques to measure event-related potentials (ERPs). The emotional face-word Stroop task in which emotion words are written in prominent red color across a face was use to study emotional conflict. In each trial, the emotion word and facial expression were either congruent or incongruent (in conflict). When subjects were asked to identify the expression of the face during a trial, the incongruent condition evoked a more negative N170 ERP component in posterior lateral sites than in the congruent condition. In contrast, when subjects were asked to identify the word during a trial, the incongruent condition evoked a less negative N170 component than the congruent condition. The present findings extend our understanding of the control processes involved in emotional conflict by demonstrating that differentiation of emotional congruency begins at an early perceptual processing stage.
Study protocol: Improving patient choice in treating low back pain (IMPACT - LBP): A randomised controlled trial of a decision support package for use in physical therapy

BACKGROUND
Low back pain is a common and costly condition. There are several treatment options for people suffering from back pain, but there are few data on how to improve patients' treatment choices. This study will test the effects of a decision support package (DSP), designed to help patients seeking care for back pain to make better, more informed choices about their treatment within a physiotherapy department. The package will be designed to assist both therapist and patient.


METHODS/DESIGN
Firstly, in collaboration with physiotherapists, patients and experts in the field of decision support and decision aids, we will develop the DSP. The work will include: a literature and evidence review; secondary analysis of existing qualitative data; exploration of patients' perspectives through focus groups and exploration of experts' perspectives using a nominal group technique and a Delphi study.Secondly, we will carry out a pilot single centre randomised controlled trial within NHS Coventry Community Physiotherapy. We will randomise physiotherapists to receive either training for the DSP or not. We will randomly allocate patients seeking treatment for non specific low back pain to either a physiotherapist trained in decision support or to receive usual care. Our primary outcome measure will be patient satisfaction with treatment at three month follow-up. We will also estimate the cost-effectiveness of the intervention, and assess the value of conducting further research.


DISCUSSION
Informed shared decision-making should be an important part of any clinical consultation, particularly when there are several treatments, which potentially have moderate effects. The results of this pilot will help us determine the benefits of improving the decision-making process in clinical practice on patient satisfaction.


TRIAL REGISTRATION
Current Controlled Trials ISRCTN46035546.