LLukas22/scidocs huggingface dataset:
Against Ambiguity

This paper argues that the widespread beliefthat ambiguity is beneficial in designcommunication stems from conceptual confusion.Communicating imprecise, uncertain andprovisional ideas is a vital part of designteamwork, but what is uncertain and provisionalneeds to be expressed as clearly as possible.Understanding what uncertainty informationdesigners can and should communicate, and how,is an urgent task for research. Viewing designcommunication as conveying permitted spaces forfurther designing is a useful rationalisationfor understanding what designers need fromtheir notations and computer tools, to achieveclear communication of uncertain ideas. Thepaper presents a typology of ways that designscan be uncertain. It discusses how sketches andother representations of designs can be bothintrinsically ambiguous, and ambiguous ormisleading by failing to convey informationabout uncertainty and provisionality, withreference to knitwear design, wherecommunication using inadequate representationscauses severe problems. It concludes thatsystematic use of meta-notations for conveyingprovisionality and uncertainty can reduce theseproblems.
Boundary and inertia effects on flow and heat transfer in porous media

The present work analyzes the effects of a solid boundary and the inertial forces on flow and heat transfer in porous media. Specific attention is given to flow through a porous medium in the vicinity of an impermeable boundary. The local volume-averaging technique has been utilized to establish the governing equations, along with an indication of physical limitations and assumptions made in the course of this development. A numerical scheme for the governing equations has been developed to investigate the velocity and temperature fields inside a porous medium near an impermeable boundary, and a new concept of the momentum boundary layer central to the numerical routine is presented. The boundary and inertial effects are characterized in terms of three dimensionless groups, and these effects are shown to be more pronounced in highly permeable media, high Prandtl-num~r fluids, large pressure gradients, and in the region close to the leading edge of the flow boundary layer.
Light propagation and large-scale inhomogeneities

We consider the effect on the propagation of light of inhomogeneities with sizes of order 10 Mpc or larger. The Universe is approximated through a variation of the Swiss-cheese model. The spherical inhomogeneities are void-like, with central underdensities surrounded by compensating overdense shells. We study the propagation of light in this background, assuming that the source and the observer occupy random positions, so that each beam travels through several inhomogeneities at random angles. The distribution of luminosity distances for sources with the same redshift is asymmetric, with a peak at a value larger than the average one. The width of the distribution and the location of the maximum increase with increasing redshift and length scale of the inhomogeneities. We compute the induced dispersion and bias on cosmological parameters derived from the supernova data. They are too small to explain the perceived acceleration without dark energy, even when the length scale of the inhomogeneities is comparable to the horizon distance. Moreover, the dispersion and bias induced by gravitational lensing at the scales of galaxies or clusters of galaxies are larger by at least an order of magnitude. Light Propagation and Large-Scale Inhomogeneities 2
Response to letter regarding article, "postprocedural aortic regurgitation in balloon-expandable and self-expandable transcatheter aortic valve replacement procedures: analysis of predictors and impact on long-term mortality: insights from the FRANCE2 registry".

T ranscatheter aortic valve replacement (TAVR) is a technique to treat patients with symptomatic aortic steno-sis and contraindications or at high risk for conventional surgical valve replacement. 1 Two revalving devices based on different technical concepts, self-expandable (SE) or balloon-expandable (BE), have been developed and are currently available. Background—Significant postprocedural aortic regurgitation (AR) is observed in 10% to 20% of cases after transcatheter aortic valve replacement (TAVR). The prognostic value and the predictors of such a complication in balloon-expandable (BE) and self-expandable (SE) TAVR remain unclear. Methods and Results—TAVR was performed in 3195 consecutive patients at 34 hospitals. Postprocedural transthoracic echocardiography was performed in 2769 (92%) patients of the eligible population, and these patients constituted the study group. Median follow-up was 306 days (Q1–Q3=178–490). BE and SE devices were implanted in 67.6% (n=1872) and 32.4% (n=897). Delivery was femoral (75.3%) or nonfemoral (24.7%). A postprocedural AR≥grade 2 was observed in 15.8% and was more frequent in SE (21.5%) than in BE-TAVR (13.0%, P=0.0001). Extensive multivariable analysis confirmed that the use of a SE device was one of the most powerful independent predictors of postprocedural AR≥grade 2. For BE-TAVR, 8 independent predictors of postprocedural AR≥grade 2 were identified including femoral delivery (P=0.04), larger aortic annulus (P=0.0004), and smaller prosthesis diameter (P=0.0001). For SE-TAVR, 2 independent predictors were identified including femoral delivery(P=0.0001). Aortic annulus and prosthesis diameter were not predictors of postprocedural AR for SE-TAVR. A postprocedural AR≥grade 2, but not a postprocedural AR=grade 1, was a strong independent predictor of 1-year mortality for BE (hazard ratio=2.50; P=0.0001) and SE-TAVR (hazard ratio=2.11; P=0.0001). Although postprocedural AR≥grade 2 was well tolerated in patients with AR≥grade 2 at baseline (1-year mortality=7%), it was associated with a very high mortality in other subgroups: renal failure (43%), AR<grade 2 at baseline (31%), low transaortic gradient (35%), or nonfemoral delivery (45%). Conclusions—Postprocedural AR≥grade 2 was observed in 15.8% of successful TAVR and was the strongest independent predictor of 1-year mortality. The use of the SE device was a powerful independent predictor of postprocedural AR≥grade 2.
The mineralocorticoid receptor agonist, fludrocortisone, differentially inhibits pituitary–adrenal activity in humans with psychotic major depression

INTRODUCTION
Hypothalamic-pituitary-adrenal (HPA) axis dysregulation has been linked with major depression, particularly psychotic major depression (PMD), with mineralocorticoid receptors (MRs) playing a role in HPA-axis regulation and the pathophysiology of depression. Herein we hypothesize that the MR agonist fludrocortisone differentially inhibits the HPA axis of psychotic major depression subjects (PMDs), non-psychotic major depression subjects (NPMDs), and healthy control subjects (HCs).


METHODS
Fourteen PMDs, 16 NPMDs, and 19 HCs were admitted to the Stanford University Hospital General Clinical Research Center. Serum cortisol levels were sampled at baseline and every hour from 18:00 to 23:00h, when greatest MR activity is expected, on two consecutive nights. On the second afternoon at 16:00h all subjects were given 0.5mg fludrocortisone. Mean cortisol levels pre- and post-fludrocortisone and percent change in cortisol levels were computed.


RESULTS
There were no significant group differences for cortisol at baseline: F(2,47)=.19, p=.83. There were significant group differences for post-fludrocortisone cortisol: F(2,47)=5.13, p=.01, which were significantly higher in PMDs compared to HCs (p=.007), but not compared to NPMDs (p=.18). There were no differences between NPMD's and HC's (p=.61). Also, PMDs had a lower percent change from baseline in cortisol levels at 2200h than NPMDs (p=.01) or HCs (p=.009).


CONCLUSIONS
Individuals with psychotic major depression compared to healthy control subjects have diminished feedback inhibition of the hypothalamic-pituitary-adrenal (HPA) axis in response to the mineralocorticoid receptor agonist fludrocortisone. To our knowledge, this is the first study to examine HPA axis response to MR stimulation in major depression (with and without psychosis), and only the third study to demonstrate that exogenously administered fludrocortisone can down-regulate the HPA axis in humans.
Study on co-pyrolysis characteristics of rice straw and Shenfu bituminous coal blends in a fixed bed reactor.

Co-pyrolysis behaviors of rice straw and Shenfu bituminous coal were studied in a fixed bed reactor under nitrogen atmosphere. The pyrolysis temperatures were 700°C, 800°C and 900°C, respectively. Six different biomass ratios were used. Gas, tar components were analyzed by a gas chromatograph and a gas chromatography-mass spectrometry respectively. Under co-pyrolysis conditions, the gas volume yields are higher than the calculated values. Co-pyrolysis tar contains more phenolics, less oxygenate compounds than calculated values. The addition of biomass changes the atmosphere during the pyrolysis process and promotes tar decomposition. The SEM results show that the differences between the blended char and their parents char are not significant. The results of char yields and ultimate analysis also show that no significant interactions exist between the two kinds of particles. The changes of gas yield and components are caused by the secondary reactions and tar decomposition.
Optimisation of machining parameters in interrupted cylindrical grinding using the Grey-based Taguchi method

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Hyperbolic Embedding and Routing for Dynamic Graphs

We propose an embedding and routing scheme for arbitrary network connectivity graphs, based on greedy routing and utilizing virtual node coordinates. In dynamic multihop packet-switching communication networks, routing elements can join or leave during network operation or exhibit intermittent failures. We present an algorithm for online greedy graph embedding in the hyperbolic plane that enables incremental embedding of network nodes as they join the network, without disturbing the global embedding. Even a single link or node removal may invalidate the greedy routing success guarantees in network embeddings based on an embedded spanning tree subgraph. As an alternative to frequent reembedding of temporally dynamic network graphs in order to retain the greedy embedding property, we propose a simple but robust generalization of greedy distance routing called Gravity–Pressure (GP) routing. Our routing method always succeeds in finding a route to the destination provided that a path exists, even if a significant fraction of links or nodes is removed subsequent to the embedding. GP routing does not require precomputation or maintenance of special spanning subgraphs and, as demonstrated by our numerical evaluation, is particularly suitable for operation in tandem with our proposed algorithm for online graph embedding.
Scrum of scrums solution for large size teams using scrum methodology

Scrum is a structured framework to support complex product development. However, Scrum methodology faces a challenge of managing large teams. To address this challenge, in this paper we propose a solution called Scrum of Scrums. In Scrum of Scrums, we divide the Scrum team into teams of the right size, and then organize them hierarchically into a Scrum of Scrums. The main goals of the proposed solution are to optimize communication between teams in Scrum of Scrums; to make the system work after integration of all parts; to reduce the dependencies between the parts of system; and to prevent the duplication of parts in the system. [Qurashi SA, Qureshi MRJ. Scrum of Scrums Solution for Large Size Teams Using Scrum Methodology. Life Sci J 2014;11(8):443-449]. (ISSN:1097-8135). http://www.lifesciencesite.com. 58
Boosting for transfer learning with multiple sources

Transfer learning allows leveraging the knowledge of source domains, available a priori, to help training a classifier for a target domain, where the available data is scarce. The effectiveness of the transfer is affected by the relationship between source and target. Rather than improving the learning, brute force leveraging of a source poorly related to the target may decrease the classifier performance. One strategy to reduce this negative transfer is to import knowledge from multiple sources to increase the chance of finding one source closely related to the target. This work extends the boosting framework for transferring knowledge from multiple sources. Two new algorithms, MultiSource-TrAdaBoost, and TaskTrAdaBoost, are introduced, analyzed, and applied for object category recognition and specific object detection. The experiments demonstrate their improved performance by greatly reducing the negative transfer as the number of sources increases. TaskTrAdaBoost is a fast algorithm enabling rapid retraining over new targets.
Beneficial effects of hypnosis and adverse effects of empathic attention during percutaneous tumor treatment: when being nice does not suffice.

PURPOSE
To determine how hypnosis and empathic attention during percutaneous tumor treatments affect pain, anxiety, drug use, and adverse events.


MATERIALS AND METHODS
For their tumor embolization or radiofrequency ablation, 201 patients were randomized to receive standard care, empathic attention with defined behaviors displayed by an additional provider, or self-hypnotic relaxation including the defined empathic attention behaviors. All had local anesthesia and access to intravenous medication. Main outcome measures were pain and anxiety assessed every 15 minutes by patient self-report, medication use (with 50 mug fentanyl or 1 mg midazolam counted as one unit), and adverse events, defined as occurrences requiring extra medical attention, including systolic blood pressure fluctuations (> or =50 mm Hg change to >180 mm Hg or <105 mm Hg), vasovagal episodes, cardiac events, and respiratory impairment.


RESULTS
Patients treated with hypnosis experienced significantly less pain and anxiety than those in the standard care and empathy groups at several time intervals and received significantly fewer median drug units (mean, 2.0; interquartile range [IQR], 1-4) than patients in the standard (mean, 3.0; IQR, 1.5-5.0; P = .0147) and empathy groups (mean, 3.50; IQR, 2.0-5.9; P = .0026). Thirty-one of 65 patients (48%) in the empathy group had adverse events, which was significantly more than in the hypnosis group (eight of 66; 12%; P = .0001) and standard care group (18 of 70; 26%; P = .0118).


CONCLUSIONS
Procedural hypnosis including empathic attention reduces pain, anxiety, and medication use. Conversely, empathic approaches without hypnosis that provide an external focus of attention and do not enhance patients' self-coping can result in more adverse events. These findings should have major implications in the education of procedural personnel.
Catch Me If You Can: A Cloud-Enabled DDoS Defense

We introduce a cloud-enabled defense mechanism for Internet services against network and computational Distributed Denial-of-Service (DDoS) attacks. Our approach performs selective server replication and intelligent client re-assignment, turning victim servers into moving targets for attack isolation. We introduce a novel system architecture that leverages a "shuffling" mechanism to compute the optimal re-assignment strategy for clients on attacked servers, effectively separating benign clients from even sophisticated adversaries that persistently follow the moving targets. We introduce a family of algorithms to optimize the runtime client-to-server re-assignment plans and minimize the number of shuffles to achieve attack mitigation. The proposed shuffling-based moving target mechanism enables effective attack containment using fewer resources than attack dilution strategies using pure server expansion. Our simulations and proof-of-concept prototype using Amazon EC2 [1] demonstrate that we can successfully mitigate large-scale DDoS attacks in a small number of shuffles, each of which incurs a few seconds of user-perceived latency.
ISSARS: An integrated software environment for structure-specific earthquake ground motion selection

motion selection DTU Orbit (12/12/2018)  ISSARS: An integrated software environment for structure-specific earthquake ground motion selection Current practice enables the design and assessment of structures in earthquake prone areas by performing time history analysis with the use of appropriately selected strong ground motions. This study presents a Matlab-based software environment, which is integrated with a finite element analysis package, and aims to improve the efficiency of earthquake ground motion selection by accounting for the variability of critical structural response quantities. This additional selection criterion, which is tailored to the specific structure studied, leads to more reliable estimates of the mean structural response quantities used in design, while fulfils the criteria already prescribed by the European and US seismic codes and guidelines. To demonstrate the applicability of the software environment developed, an existing irregular, multi-storey, reinforced concrete building is studied for a wide range of seismic scenarios. The results highlight the applicability of the software developed and the benefits of applying a structure-specific criterion in the process of selecting suites of earthquake motions for the seismic design and assessment. (C) 2013 Elsevier Ltd. All rights reserved.
The Use of Mobile Money Application and Smallholder Farmer Market Participation: Evidence form Cote d Ivoire and Tanzania

With the growing food security concerns market participation of smallholder farmers has regained the attention of policy makers and agricultural development community. The widespread adoption of information and communication technologies in Sub-Saharan Africa over the last decade have paved the way for the introduction of digital solutions such as mobile money that have a potential to enhance access to input and output markets. Using a conceptual framework based on the Transaction Cost Economics theory, we propose a hypothesis that the ability to make quick and low-cost money transfers through mobile money application can lower the transaction costs associated with hold-up risks of participating in distant markets. This hypothesis is tested using the data from the CGAP survey in Cote d Ivoire and Tanzania. The methods include Heckman Probit model to account for sample selection bias. The findings indicate that the stallholder farmers who use the mobile money for receiving payments from buyers are more likely to sell their product in city and regional markets versus farm gate options such as middleman and village markets. Key words: market participation, mobile money, transaction costs, Sub-Saharan Africa Acknowledgement :
Perspectives on technology mediated learning in secondary school mathematics classrooms

The introduction of technology resources into mathematics classrooms promises to create opportunities for enhancing students’ learning through active engagement with mathematical ideas; however, little consideration has been given to the pedagogical implications of technology as a mediator of mathematics learning. This paper draws on data from a three year longitudinal study of senior secondary school classrooms to examine pedagogical issues in using technology in mathematics teaching – where “technology” includes not only computers and graphics calculators but also projection devices that allow screen output to be viewed by the whole class. We theorise and illustrate four roles for technology in relation to such teaching and learning interactions – master, servant, partner, and extension of self. Our research shows how technology can facilitate collaborative inquiry, during both small group interactions and whole class discussions where students use the computer or calculator and screen projection to share and test their mathematical understanding.
Systemic Immune Suppression Predicts Diminished Merkel Cell Carcinoma – Specific Survival Independent of Stage

Merkel cell carcinoma (MCC) is an aggressive cutaneous malignancy linked to a contributory virus (Merkel cell polyomavirus). Multiple epidemiologic studies have established an increased incidence of MCC among persons with systemic immune suppression. Several forms of immune suppression are associated with increased MCC incidence, including hematologic malignancies, HIV/AIDS, and immunosuppressive medications for autoimmune disease or transplant. Indeed, immune-suppressed individuals represent B10% of MCC patients, a significant overrepresentation relative to the general population. We hypothesized that immune-suppressed patients may have a poorer MCC-specific prognosis and examined a cohort of 471 patients with a combined follow-up of 1,427 years (median 2.1 years). Immune-suppressed patients (n1⁄4 41) demonstrated reduced MCC-specific survival (40% at 3 years) compared with patients with no known systemic immune suppression (n1⁄4 430; 74% MCC-specific survival at 3 years). By competing risk regression analysis, immune suppression was a stage-independent predictor of worsened MCC-specific survival (hazard ratio 3.8, Po0.01). Thus, immune-suppressed individuals have both an increased chance of developing MCC and poorer MCC-specific survival. It may be appropriate to follow these higher-risk individuals more closely, and, when clinically feasible, there may be a benefit of diminishing iatrogenic systemic immune suppression.
Micturitional dryness and attitude of parents towards enuresis in children attending outpatient unit of a tertiary hospital in Abeokuta, Southwest Nigeria.

BACKGROUND
There is significant variability of the age at which children achieve dryness.


OBJECTIVES
We determine the age at achievement of micturational dryness and attitude of parents about enuresis among urban Nigerian children.


METHOD
A total of 346 questionnaires were administered to parents of children between the ages of 12 - 180 months who came for routine paediatric care at the outpatient unit of Federal Medical Centre, Abeokuta.


RESULTS
At age 36 months, 86 (51.8 %) and 34 (20.5 %) out of 166 children had achieved dryness at daytime and night time respectively. Achievement of dryness was significantly related to low maternal education (p = 0.022) and low social class (p = 0.009). Twenty-four (26.7 %) children had nocturnal enuresis. Four (4.4 %) of these children also had diurnal enuresis. All the parents/guardians were aware about enuresis but only 9.8 % correctly identified it as a health problem. Even though none of the children with enuresis ever visited health facility for their problem, a statistically significant proportion of the parents desire to discuss with health practitioners (p = 0.015).


CONCLUSIONS
The proportion of children achieving dryness by age 36 months is very small when compared with children from developed parts of the world. There is also a high prevalence of enuresis which are not reported. Therefore, health workers in the tropics should as a routine enquire about enuresis in their daily paediatric care particularly for those children from polygamous homes and high social class.