LLukas22/scidocs huggingface dataset:
Treatment of Helicobacter pylori in patients with duodenal ulcer hemorrhage— a long-term randomized, controlled study

OBJECTIVE:Eradication of Helicobacter pylori (H. pylori) in patients with uncomplicated duodenal ulcers prevents long-term recurrence of ulcers. We aimed to study whether treatment of H. pylori prevents the long-term recurrence of duodenal ulcer hemorrhage.METHODS:Patients with duodenal ulcer bleeding and confirmed H. pylori infection were recruited. A total of 120 patients were randomly assigned to triple therapy (DeNoltab 120 mg, amoxycillin 500 mg, and metronidazole 300 mg four times daily) or DeNoltab 120 mg four times daily alone. No maintenance therapy was given during the follow-up period. The endpoints were the cumulative rates of symptomatic and bleeding duodenal ulcer recurrences.RESULTS:Of the patients receiving the triple regimen, 85.1% had H. pylori eradicated as compared to 2.0% of patients receiving DeNoltab (p < 0.05). More patients in the DeNoltab group than those in the Triple group had recurrence of ulcer bleeding, but this did not reach statistical significance (12/60 vs 6/60, p = 0.20). Logistic regression analysis on clinical, personal, and endoscopic characteristics identified persistent H. pylori infection as the only independent predictor of recurrence of duodenal ulcer bleeding.CONCLUSIONS:Treatment of H. pylori alone with the present bismuth-based triple therapy in patients with duodenal ulcer hemorrhage did not result in significant reduction in further bleeding episodes, although a trend was seen for the group that was given triple therapy. On the other hand, posttreatment H. pylori status was found to be an independent predictor of bleeding recurrence.
Burnout in Counselor Education: The Role of Cynicism and Fit in Predicting Turnover Intention

This study explored the experience of burnout in counselor education faculty, and how it relates to perceived worklife fit and turnover intention. Participants experienced a moderate level of burnout in the areas of exhaustion, cynicism, and professional inefficacy. The results of a MANOVA revealed that male and female participants differed on a composite measure of burnout, fit, and turnover intention, but there were no significant multivariate differences based on race or tenure status. Both cynicism and perceived worklife fit uniquely contributed to the prediction of turnover intention, together explaining 29% of the total variance in turnover intention. Further directions for research in this population were discussed. Author's Notes The authors would like to gratefully acknowledge Greg Hatchett for his mentorship and feedback throughout the process. Thanks are also due to colleagues and friends, past and present, whose guidance, feedback, and support have been invaluable.
Amino acids and antioxidant properties of the oyster mushrooms , Pleurotus ostreatus and Pleurotus sajor-caju

The objective of this study was to investigate the amino acid composition and antioxidant properties of two oyster mushroom species, Pleurotus ostreatus andPleurotus sajor-caju , commercially cultivated in NE Thailand. Proximate composition and dietary fibre of dried mushrooms were determined. Amino acid composition of fresh mushrooms was analysed by HPLC. Water and ethanol extracts were obtained from dried mushrooms and determined for total phenolic contents (TPC) by the Folin-Ciocalteu method, free radical scavenging efficacy by the DPPH method, and reducing power by the ferric reducing-antioxidant power method. Except for protein, proximate compositions of dried mushrooms were significantly different. Similar amino acid profiles in both mushrooms were obtained, with glutamic acid, aspartic acid, and arginine being the three most abundant. Water extracts contained higher TPC and possessed better antioxidant activities than did ethanol extracts for both mushrooms. Overall, P. ostreatuspossessed more antioxidant than P. sajor-caju. The EC50 of P. ostreatusandP. sajor-cajuwater extracts were 11.56 and 13.38 mg/ml, respectively, while those of the ethanol extracts were 31.75 and 58.44 mg/ml, respectively.
The Topological Space E 2 T . Simple Closed Curves

The notation and terminology used here have been introduced in the following articles: [22], [21], [14], [1], [24], [20], [6], [7], [18], [4], [8], [23], [17], [25], [11], [16], [9], [19], [2], [5], [15], [3], [10], [12], and [13]. We follow the rules: p1, p2, q1, q2 will denote points of E 2 T and P , Q, P1, P2 will denote subsets of E 2 T . The following propositions are true: (1) If p1 6= p2 and p1 ∈ E and p2 ∈ E2, then there exist P1, P2 such that P1 is an arc from p1 to p2 and P2 is an arc from p1 to p2 and E = P1∪P2 and P1 ∩ P2 = {p1, p2}. (2) E is compact. (3) For every map f from (E T ) Q into (E T ) P such that f is a homeomorphism and Q is an arc from q1 to q2 and P 6= ∅ and for all p1, p2 such that p1 = f(q1) and p2 = f(q2) holds P is an arc from p1 to p2. Let us consider P . We say that P is a simple closed curve if and only if: (Def.1) P 6= ∅ and there exists a map f from (E 2 T ) E into (E T) P such that f is a homeomorphism.
Timing of multiple late Quaternary glaciations in the Hunza Valley, Karakoram Mountains, northern Pakistan: Defined by cosmogenic radionuclide dating of moraines

Moraines and associated landforms in the upper Hunza Valley, Karakoram Mountains, northern Pakistan, provide an excellent record of multiple glaciations. During the late Quaternary, glaciers advanced at least eight times. By using 10Be and 26Al surface-exposure dating on moraine boulders and scoured bedrock, we determined the timing of glaciation for four of these glacial advances: ca. 54.7–43.2 ka (Borit Jheel glacial stage), ca. 25.7–21.8 ka (Ghulkin I glacial stage), ca. 18.4–15.3 ka (Ghulkin II glacial stage), and ca. 10.8–9.0 ka (Batura glacial stage). For two of the older advances, the Yunz and Shanoz glacial stages, our data set a limit of .60 ka. Although, at present, the uncertainties in dating make it impossible to describe unequivocally the climate processes controlling glaciations in the Hunza Valley, the results suggest that precipitation changes related to oscillations in the southwest Asian monsoonal system combine with cooling that is broadly associated with Heinrich events to cause glacial advances in this region.
DISCRETE SCALE INVARIANCE IN STOCK MARKETS BEFORE CRASHES

We propose a picture of stock market crashes as critical points in a hierachical system with discrete scaling. The critical exponent is then complex, leading to log-periodic fluctuations in stock market indexes. We present " experimental " evidence in favor of this prediction. This picture is in the spirit of the known earthquake-stock market analogy and of recent work on log-periodic fluctuations associated with earthquakes. The study of earthquakes as critical points has been of interest for some time now [1, 2, 3, 4, 5]. At a critical point one expects a scaling regime to set in. Recently it has been suggested [6, 7] that the underlying scale invariance is discrete, as expected for a hierarchical system. Then the critical exponent is complex and the scaling law near the critical point is " decorated " by log-periodic corrections (ℜτ α+iω = τ α cos(ω log τ)) Evidence for such log-periodic fluctuations was found [6] in measurements of the concentration of Cl − and SO −− 4 ions in mineral water collected over the 20 months immediately pre-ceeding the 1995 Kobe earthquake at a source close to its epicenter. Similar evidence was also found [7] in the cumulative Benioff strain in connection with the 1989 Loma Prieta earthquake. It was proposed [6] that monitoring log-periodic fluctuations may ultimately prove useful in earthquake prediction. Such fluctuations seem generic in hierarchically organized rupture processes. In the spirit of an earthquake-stock market analogy, this has led us to consider the possibility that log-periodic fluctuations may appear in stock market indices over a period preceding a crash. The stock market index (S&P 500, Dow-Jones, NIKKEI, ...) is to play here the same role as the Cl − ion concentration played in the the analysis of the Kobe earthquake. Fortunately such indices are closely monitored and good data are plentiful. The scaling 1 variable is again time t. Call c(t) the index as a function of time. Truncating at the first harmonic of a general log-periodic correction, we can then write for c(t) the same formula as that given in [6] for the ion concentration c(t) = A + B(t c − t) α [1 + C cos[ω log(t c − t) + ϕ]]. (1) As a first test of this idea let us consider the crash which occured in New York on October 19, 1987. As the relevant index let us use the S&P 500, …
Indoor air quality monitoring using wireless sensor network

Indoor air quality (IAQ) is a term describing the air quality of a building; especially it refers to the health and comfort of building occupants. It refers to the nature of the conditioned air that circulates throughout space/area, where we work and live in. IAQ can be affected by microbial contaminants (mold, fungus) which largely depend on temperature and humidity condition of a room, gaseous pollutants (including carbon monoxide, carbon dioxide, volatile organic compounds etc) and dust particles or aerosols. These pollutants can induce adverse health effects to building occupants. To avoid such adverse effects, an air quality monitoring system is utmost required. This paper aims to develop a wireless solution for indoor air quality monitoring. The proposed solution is to measure the environmental parameters like temperature, humidity, gaseous pollutants, aerosol/Particulate Matter to determine the environmental health of an indoor space. It also represents that in terms of Air Quality Index (AQI) and gives environmental information as input for controlling HVAC (Heating, Ventilation and Air Conditioning) system in a smart building. A toolkit has been developed to view the live air quality data of deployed regions in the form of numbers and graphs.
The natural history of primary progressive multiple sclerosis.

BACKGROUND
Primary progressive multiple sclerosis (PPMS) carries the worst prognosis of the multiple sclerosis (MS) subtypes and is currently untreatable. A previous analysis of the British Columbia MS database challenged the view that disability progression is rapid in PPMS, but identified few predictors of disease progression. Here, we extend previous analyses in an updated PPMS retrospective cohort study of prevalent cases.


METHODS
We used Kaplan-Meier survival analyses and Cox regression models to investigate the influence of gender, age at onset, and onset symptoms on time to and age at Expanded Disability Status Scale (EDSS) 6.0 in patients with PPMS.


RESULTS
Of 5,779 patients with definite MS, 552 (10%) had PPMS. Median time to EDSS 6.0 was 14.0 years (95% confidence interval [CI] 11.3-16.7), reached at a median age of 58.6 years (95% CI 56.8-60.3). Sensory onset symptoms were associated with a longer time to and an older age at EDSS 6.0 (multivariable hazard ratios 0.55 [95% CI 0.35-0.87] and 0.54 [0.35-0.85]). Younger age at disease onset was associated with a longer time to but a younger age at EDSS 6.0. Gender and other onset symptoms were not associated with these outcomes. Fifty patients with PPMS (9%) fulfilled criteria for benign MS (EDSS < or =3.0 after 10 years' disease duration).


CONCLUSIONS
We identified 2 predictors of a slower disease progression in primary progressive multiple sclerosis. Sensory onset symptoms were associated with both a longer time to and a higher age at Expanded Disability Status Scale (EDSS) 6.0. A younger age at disease onset was associated with a longer time to EDSS 6.0, but patients with an early disease onset reached EDSS 6.0 at a younger age.
Effects of altitude on performance of elite track-and-field athletes.

PURPOSE
Lower barometric air pressure at altitude can affect competitive performance of athletes in some sports. Reported here are the effects of various altitudes on elite track-and-field athletes' performance.


METHODS
Lifetime track-and-field performances of athletes placed in the top 16 in at least 1 major international competition between 2000 and 2009 were downloaded from the database at tilastopaja.org. There were 132,104 performances of 1889 athletes at 794 venues. Performances were log-transformed and analyzed using a mixed linear model with fixed effects for 6 levels of altitude and random quadratic effects to adjust for athlete age.


RESULTS
Men's and women's sprint events (100-400 m) showed marginal improvements of ~0.2% at altitudes of 500-999 m, and above 1500 m all but the 100- and 110-m hurdles showed substantial improvements of 0.3-0.7%. Some middle- and long-distance events (800-10,000 m) showed marginal impairments at altitudes above 150 m, but above 1000 m the impairments increased dramatically to ~2-4% for events >800 m. There was no consistent trend in the effects of altitude on field events up to 1000 m; above 1000 m, hammer throw showed a marginal improvement of ~1% and discus was impaired by 1-2%. Above 1500 m, triple jump and long jump showed marginal improvements of ~1%.


CONCLUSIONS
In middle-and long-distance runners, altitudes as low as 150 to 299 m can impair performance. Higher altitudes (≥1000 m) are generally required before decreases in discus performance or enhancements in sprinting, triple and long jump, or hammer throw are seen.
Why Share Knowledge? The Influence of ICT on the Motivation for Knowledge Sharing

Information and communication technology (ICT) can enhance knowledge sharing by lowering temporal and spatial barriers between knowledge workers, and improving access to information about knowledge. Looking at ICT for knowledge sharing in this light, however, has limited value, because it ignores when and how the quality of knowledge sharing will be enhanced. A more encompassing perspective will come about if ICT is studied with relation to the motivation for knowledge sharing. The article explores this perspective by developing a theoretical model identifying and linking the variables involved. By presenting the outcomes of an empirical investigation, it also illustrates the differential effects of ICT on the motivation for knowledge sharing in different settings. Copyright ? 1999 John Wiley & Sons, Ltd and Cornwallis Emmanuel Ltd.
Interventional versus conservative treatment for patients with unstable angina or non-ST-elevation myocardial infarction: the British Heart Foundation RITA 3 randomised trial

BACKGROUND
Current guidelines suggest that, for patients at moderate risk of death from unstable coronary-artery disease, either an interventional strategy (angiography followed by revascularisation) or a conservative strategy (ischaemia-driven or symptom-driven angiography) is appropriate. We aimed to test the hypothesis that an interventional strategy is better than a conservative strategy in such patients.


METHODS
We did a randomised multicentre trial of 1810 patients with non-ST-elevation acute coronary syndromes (mean age 62 years, 38% women). Patients were assigned an early intervention or conservative strategy. The antithrombin agent in both groups was enoxaparin. The co-primary endpoints were a combined rate of death, non-fatal myocardial infarction, or refractory angina at 4 months; and a combined rate of death or non-fatal myocardial infarction at 1 year. Analysis was by intention to treat.


FINDINGS
At 4 months, 86 (9.6%) of 895 patients in the intervention group had died or had a myocardial infarction or refractory angina, compared with 133 (14.5%) of 915 patients in the conservative group (risk ratio 0.66, 95% CI 0.51-0.85, p=0.001). This difference was mainly due to a halving of refractory angina in the intervention group. Death or myocardial infarction was similar in both treatment groups at 1 year (68 [7.6%] vs 76 [8.3%], respectively; risk ratio 0.91, 95% CI 0.67-1.25, p=0.58). Symptoms of angina were improved and use of antianginal medications significantly reduced with the interventional strategy (p<0.0001).


INTERPRETATION
In patients presenting with unstable coronary-artery disease, an interventional strategy is preferable to a conservative strategy, mainly because of the halving of refractory or severe angina, and with no increased risk of death or myocardial infarction.
Building the Internet of Things with bluetooth smart

The Internet of Things, or the IoT, is an emerging, disruptive technology that enables physical devices to communicate across disparate networks. IP has been the de facto standard for seamless interconnectivity in the traditional Internet; and piggybacking on the success of IP, 6LoWPAN has been the first standardized technology to realize it for networks of resource-constrained devices. In the recent past Bluetooth Low Energy (BLE) a.k.a Bluetooth Smart a subset of the Bluetooth v4.0 and the latest v4.2 stack, has surfaced as an appealing alternative, with many competing advantages over available low-power communication technologies in the IoT space such as IEEE 802.15.4. However, BLE is a closed standard and lacks open hardware and firmware support, something that hinders innovation and development in this field. In this article, we aim to overcome some of the constraints in BLE’s core building blocks by making three contributions: first, we present the design of a new open hardware platform for BLE; second, we provide a Contiki O.S. port for the new platform; and third, we identify research challenges and opportunities in 6LoWPAN-connected Bluetooth Smart. We believe that the knowledge and insights will facilitate IoT innovations based on this promising technology. © 2016 Elsevier B.V. All rights reserved.
Improving the Information Security Model by using TFI

In the context of information systems and information technology, information security is a concept that is becoming widely used. The European Network of Excellence INTEROP classifies information security as a nonfunctional aspect of interoperability and as such it is an integral part of the design process for interoperable systems. In the last decade, academics and practitioners have shown their interest in information security, for example by developing security models for evaluating products and setting up security specifications in order to safeguard the confidentiality, integrity, availability and accountability of data. Earlier research has shown that measures to achieve information security in the administrative or organisational level are missing or inadequate. Therefore, there is a need to improve information security models by including vital elements of information security. In this paper, we introduce a holistic view of information security based on a Swedish model combined with a literature survey. Furthermore we suggest extending this model using concepts based on semiotic theory and adopting the view of an information system as constituted of the technical, formal and informal (TFI) parts. The aim is to increase the understanding of the information security domain in order to develop a well-founded theoretical framework, which can be used both in the analysis and the design phase of interoperable systems. Finally, we describe and apply the Information Security (InfoSec) model to the results of three different case studies in the healthcare domain. Limits of the model will be highlighted and an extension will be proposed.
Alcohol beverage drinking, diet and body mass index in a cross-sectional survey

Objective: The study was carried out to determine the associations of alcohol beverage drinking with macronutrients, antioxidants, and body mass index. Setting: Dietary subsample of the 1992 Finmonica cardiovascular risk factor survey in Finland; a cross-sectional study. Subjects: 985 women and 863 men were drawn from the population register in the four monitoring areas. All subjects were 25–64 y of age. Methods: The mailed questionnaire included questions covering socioeconomic factors, physical activity, smoking, and alcohol consumption. The diet was assessed using a three-day food record. Results: The dietary differences between abstainers and alcohol consumers were more significant than between consumers of different alcoholic beverages. Among drinkers, fat intake as a percentage of energy was higher and carbohydrate intake was lower than among abstainers. Those who preferred wine, however, had the highest vitamin C intake; female wine drinkers also had the highest carotenoid intake. With the exception of those who mainly preferred spirits, alcohol energy was not added to the diet but seemed to substitute food items both in men and women. Despite the similar total daily energy intakes, daily energy expenditure, and physical activity index, male drinkers were leaner than abstainers. In women, the proportion of underreporters of energy intake increased with increasing alcohol consumption, and the association between alcohol and body mass index was similar to that in men after the exclusion of underreporters. Conclusions: Alcohol consumers were leaner than abstainers, and wine drinkers in particular had more antioxidants in their diet. Sponsorship: The Finnish Foundation for Alcohol Studies.
GUIR at SemEval-2017 Task 12: A Framework for Cross-Domain Clinical Temporal Information Extraction

• Medians calculated from participating systems in each task (6 unsupervised TS & ES, 5 unsupervised TA & EA, 4 unsupervised CR, 11 supervised TS & ES, 10 supervised TA & EA (modality), 9 supervised EA (others), 8 supervised CR. • Baselines: MEMORIZE for TS, ES, TA, EA. CLOSEST for CR. • TA & EA – One CRF model per attribute – Same features as for TS and ES – Extended window of ±3 • CR – Supervised classification: Gradient boosted trees – Classify each candidate relation based on type – Candidate relations are all intra-sentence entity pairs – Features: • Entity features: type, attributes, text, suffix, semantic role labeling • Relation features: token distance, constituency and dependency tree paths (n-grams)
Cell–cell and cell–matrix dynamics in intraperitoneal cancer metastasis

The peritoneal metastatic route of cancer dissemination is shared by cancers of the ovary and gastrointestinal tract. Once initiated, peritoneal metastasis typically proceeds rapidly in a feed-forward manner. Several factors contribute to this efficient progression. In peritoneal metastasis, cancer cells exfoliate into the peritoneal fluid and spread locally, transported by peritoneal fluid. Inflammatory cytokines released by tumor and immune cells compromise the protective, anti-adhesive mesothelial cell layer that lines the peritoneal cavity, exposing the underlying extracellular matrix to which cancer cells readily attach. The peritoneum is further rendered receptive to metastatic implantation and growth by myofibroblastic cell behaviors also stimulated by inflammatory cytokines. Individual cancer cells suspended in peritoneal fluid can aggregate to form multicellular spheroids. This cellular arrangement imparts resistance to anoikis, apoptosis, and chemotherapeutics. Emerging evidence indicates that compact spheroid formation is preferentially accomplished by cancer cells with high invasive capacity and contractile behaviors. This review focuses on the pathological alterations to the peritoneum and the properties of cancer cells that in combination drive peritoneal metastasis.