LLukas22/scidocs huggingface dataset:
Lord of a Visible World: An Autobiography in Letters

H.P. Lovecraft (1890-1937) has achieved renown as the leading author of supernatural fiction in the twentieth century. His novels have been translated into a dozen languages, and his work has inspired many contemporary authors in the fields of horror and science fiction, including Stephen King, Peter Straub, Ramsey Campbell, and Philip K. Dick. In Lord of a Visible World, the editors have amassed and arranged the letters of this prolific writer into the story of his life. The volume traces Lovecraft's upbringing in Providence, Rhode Island, his involvement with the pulp magazine Weird Tales, his short-lived marriage, and his later status as the preeminent man of letters in his field. In addition to conveying the candid details of his life, the volume also traces the evolution of his wide-ranging opinions. Lovecraft shows himself to be deeply engaged in the social, political, and cultural milieu of his time. The editors, two of the leading Lovecraft scholars, have meticulously edited the text, transcribing the letters from manuscript sources and supplying explanatory annotations throughout. Lord of a Visible World is of interest to both the general reader and the scholar, presenting for the first time a well-rounded portrait, in his own words, of a writer whose work has fascinated millions of readers.
Daily caffeine intake among Osijek High School students: questionnaire study.

AIM
To assess caffeine intake habits of Osijek high school students and identify the most important sources of caffeine intake.


METHODS
Adjusted Wisconsin University Caffeine Consumption Questionnaire was administered to 571 high school students (371 boys and 200 girls in the ninth grade) from Osijek, the largest town in eastern Croatia. The level of caffeine in soft drinks was determined by the high pressure liquid chromatography method, and in chocolate and coffee from the literature data.


RESULTS
Only 10% of our participants did not use foodstuffs containing caffeine. The intake of caffeine originated from soft drinks (50%), coffee (37%), and chocolate (13%). The mean caffeine concentration in soft drinks was 100-/+26.9 mg/L. The mean estimated caffeine intake was 62.8-/+59.8 mg/day. There was no statistically significant difference between boys and girls in caffeine consumption (1.0-/+0.9 mg/kg bw for boys vs 1.1-/+1.4 mg/kg bw for girls). Daily caffeine intake of 50-100 mg was recorded in 32% of girls and 29% of boys, whereas intake greater than 100 mg/day was recorded in 18% of girls and 25% of boys.


CONCLUSION
Soft drinks containing caffeine were the major source of caffeine intake in high school students. Large-scale public health measures are needed to inform the public on health issues related to excessive intake of caffeine-containing foodstuffs by children and adolescents.
BugCache for inspections: hit or miss?

Inspection is a highly effective but costly technique for quality control. Most companies do not have the resources to inspect all the code; thus accurate defect prediction can help focus available inspection resources. BugCache is a simple, elegant, award-winning prediction scheme that "caches" files that are likely to contain defects [12]. In this paper, we evaluate the utility of BugCache as a tool for focusing inspection, we examine the assumptions underlying BugCache with the aim of improving it, and finally we compare it with a simple, standard bug-prediction technique. We find that BugCache is, in fact, useful for focusing inspection effort; but surprisingly, we find that its performance, when used for inspections, is not much better than a naive prediction model -- viz., a model that orders files in the system by their count of closed bugs and chooses enough files to capture 20% of the lines in the system.
Safety and Efficacy of Nucleic Acid Polymers in Monotherapy and Combined with Immunotherapy in Treatment-Naive Bangladeshi Patients with HBeAg+ Chronic Hepatitis B Infection

UNLABELLED
Previous in vivo studies have suggested that nucleic acid polymers (NAPs) may reduce circulating levels of HBsAg in the blood by blocking its release from infected hepatocytes and that this effect may have clinical benefit. NAP treatment, was evaluated in two clinical studies in patients with HBeAg positive chronic HBV infection. The REP 101 study examined REP 2055 monotherapy in 8 patients and the REP 102 study examined REP 2139-Ca, in monotherapy in 12 patients, 9 of which transitioned to short term combined treatment with pegylated interferon alpha 2a or thymosin alpha 1. In both studies NAP monotherapy was accompanied by 2-7 log reductions of serum HBsAg, 3-9 log reductions in serum HBV DNA and the appearance of serum anti-HBsAg antibodies (10-1712 mIU / ml). Eight of the 9 patients transitioning to combined treatment with immunotherapy (pegylated interferon or thymosin alpha 1) in the REP 102 study experienced HBsAg loss and all 9 patients experienced substantial increases in serum anti-HBsAg antibody titers before withdrawal of therapy. For 52 weeks after removal of REP 2055 therapy, rebound of serum viremia (HBV DNA > 1000 copies / ml, HBsAg > 1IU / ml) was not observed in 3 / 8 patients. Suppression of serum virema was further maintained for 290 and 231 weeks in 2 of these patients. After withdrawal of all therapy in the 9 patients that transitioned to combination therapy in the REP 102 study, 8 patients achieved HBV DNA < 116 copies / ml after treatment withdrawal. Viral rebound occurred over a period of 12 to 123 weeks in 7 patients but was still absent in two patients at 135 and 137 weeks of follow-up. Administration tolerability issues observed with REP 2055 were rare with REP 2139-Ca but REP 2139-Ca therapy was accompanied by hair loss, dysphagia and dysgeusia which were considered related to heavy metal exposure endemic at the trial site. These preliminary studies suggest that NAP can elicit important antiviral responses during treatment which may improve the effect of immunotherapy. NAPs may be a potentially useful component of future combination therapies for the treatment of chronic hepatitis B.


TRIAL REGISTRATION
ClinicalTrials.gov NCT02646163 and NCT02646189.
Marketing Research Traditions: Toward Theoretical Unification or Pluralism?

Theories of marketing and their future directions are increasingly discussed topics. A significant theme is whether we can construct a unifying logic for the marketing discipline (Vargo and Lusch 2004), or whether marketing should be seen as a theoretically pluralistic field (Möller and Halinen 2000). This issue is first addressed by examining the characteristics of marketing as a scientific domain. Next, a selected set of research traditions or schools of marketing (marketing management, services marketing, marketing channels, interaction and network approach in business marketing, relationship marketing) are described in terms of their intellectual goals and metatheoretical assumptions. This evaluation suggests that the fundamental aspects in assessing the explanatory value, limitations, and relative closeness of research traditions are the assumptions they make about: (i) marketing exchange relationships, (ii) the context of this exchange, and (iii) the actors carrying out the exchanges, in addition to their epistemological and methodological bases. Lastly, the results are used to argue for the adoption of theoretical pluralism in the marketing discipline.
Etomidate speech and memory test (eSAM): a new drug and improved intracarotid procedure.

BACKGROUND
The intracarotid amobarbital procedure (IAP) is an important part of comprehensive investigation of patients who are candidates for surgical treatment of epilepsy. Owing to repeated and lengthy shortages of amobarbital, causing delays in elective surgery, attempts have been made to find a suitable alternative anesthetic. The authors report their experience using etomidate, a widely used agent for the induction of anesthesia.


METHODS
Sixteen consecutive patients requiring IAP to evaluate memory or to lateralize speech underwent the procedure using etomidate. Prior to the procedure a catheter was placed in the internal carotid artery and an angiogram was performed. EEG was recorded and read online by an electroencephalographer. An anesthetist injected the drug, administered by bolus followed by an infusion, which was maintained until each speech measure had been sampled and new memory items had been introduced. The infusion was then stopped and testing continued as in a standard IAP.


RESULTS
In all cases (30 hemispheres) contralateral hemiplegia followed injection. EEG slow waves were observed in every injected hemisphere, with some contralateral slowing anteriorly in 18. Global aphasia with preserved attention and cooperation followed dominant-hemisphere injections. These phenomena remained during infusion, and upon its termination returned gradually to baseline over a period of about 4 minutes.


CONCLUSIONS
Etomidate is a viable alternative to amobarbital, and its administration by bolus followed by infusion offers an improvement over the traditional intracarotid amobarbital procedure. Cognitive tests can be performed during an assured hemianesthesia of the injected hemisphere.
Improving management and effectiveness of home blood pressure monitoring: a qualitative UK primary care study.

BACKGROUND
Self-monitoring blood pressure (SMBP) is becoming an increasingly prevalent practice in UK primary care, yet there remains little conceptual understanding of why patients with hypertension engage in self-monitoring.


AIM
To identify psychological factors or processes prompting the decision to self-monitor blood pressure.


DESIGN AND SETTING
A qualitative study of patients previously participating in a survey study about SMBP from four general practices in the West Midlands.


METHOD
Taped and transcribed in-depth interviews with 16 patients (6 currently monitoring, 2 used to self-monitor, and 8 had never self-monitored). Thematic analysis was undertaken.


RESULTS
Three main themes emerged: 'self' and 'living with hypertension' described the emotional element of living with an asymptomatic condition; 'self-monitoring behaviour and medication' described overall views about self-monitoring, current practice, reasons for monitoring, and the impact on medication adherence; and 'the GP-patient transaction' described the power relations affecting decisions to self-monitor. Self-monitoring was performed by some as a protective tool against the fears of a silent but serious condition, whereas others self-monitor simply out of curiosity. People who self-monitored tended not to discuss this with their nurse or GP, partly due to perceiving minimal or no interest from their clinician about home monitoring, and partly due to fear of being prescribed additional medication.


CONCLUSION
The decision to self-monitor appeared often to be an individual choice with no schedule or systems to integrate it with other medical care. Better recognition by clinicians that patients are self-monitoring, perhaps utilising the results in shared decision-making, might help integrate it into daily practice.
New models for evaluation of radiation-induced lifetime cancer risk and its uncertainty employed in the UNSCEAR 2006 report.

Generalized relative and absolute risk models are fitted to the latest Japanese atomic bomb survivor solid cancer and leukemia mortality data (through 2000), with the latest (DS02) dosimetry, by classical (regression calibration) and Bayesian techniques, taking account of errors in dose estimates and other uncertainties. Linear-quadratic and linear-quadratic-exponential models are fitted and used to assess risks for contemporary populations of China, Japan, Puerto Rico, the U.S. and the UK. Many of these models are the same as or very similar to models used in the UNSCEAR 2006 report. For a test dose of 0.1 Sv, the solid cancer mortality for a UK population using the generalized linear-quadratic relative risk model is estimated as 5.4% Sv(-1) [90% Bayesian credible interval (BCI) 3.1, 8.0]. At 0.1 Sv, leukemia mortality for a UK population using the generalized linear-quadratic relative risk model is estimated as 0.50% Sv(-1) (90% BCI 0.11, 0.97). Risk estimates varied little between populations; at 0.1 Sv the central estimates ranged from 3.7 to 5.4% Sv(-1) for solid cancers and from 0.4 to 0.6% Sv(-1) for leukemia. Analyses using regression calibration techniques yield central estimates of risk very similar to those for the Bayesian approach. The central estimates of population risk were similar for the generalized absolute risk model and the relative risk model. Linear-quadratic-exponential models predict lower risks (at least at low test doses) and appear to fit as well, although for other (theoretical) reasons we favor the simpler linear-quadratic models.
Multi-criteria supplier segmentation using a fuzzy preference relations based AHP

0377-2217/$ see front matter 2012 Elsevier B.V. A http://dx.doi.org/10.1016/j.ejor.2012.09.037 ⇑ Corresponding author. Tel.: +31 15 27 81716; fax E-mail addresses: j.rezaei@tudelft.nl (J. Rezaei), j.r. 1 Tel.: +31 15 27 84815; fax: +31 15 27 83177. One of the strategic activities of a firm is supplier segmentation, whereby a firm creates groups of suppliers to handle them differently. Existing literature provides several typologies of suppliers, each of which uses different dimensions/variables. In this paper, different typologies are combined by distinguishing two overarching dimensions, the capabilities and the willingness of suppliers to cooperate with a particular firm. These dimensions cover almost all the existing supplier segmentation criteria mentioned in existing literature. For each particular situation, these dimensions can be specified using a multi-criteria decision-making method. A methodology is proposed that includes a fuzzy Analytic Hierarchy Process (AHP) which uses fuzzy preference relations to incorporate the ambiguities and uncertainties that usually exist in human judgment. The proposed methodology is used to segment the suppliers of a broiler company. The result is a segmentation of suppliers based on two aggregated dimensions. Finally some strategies to handle different segments are discussed and concluding remarks and suggestions for future research are provided. 2012 Elsevier B.V. All rights reserved.
Newborn screening for cystic fibrosis.

BACKGROUND
Does newborn screening for cystic fibrosis (CF) improve clinical outcomes, quality of life and survival?


OBJECTIVES
To examine whether newborn screening for CF prevents or reduces irreversible organ damage and improves clinical outcomes, quality of life and survival in people with CF without unacceptable adverse effects.


SEARCH STRATEGY
We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Trials Register comprising references identified from electronic database searches, handsearches of relevant journals and abstract books of conference proceedings.The Group's Trials Register last searched: June 2008.


SELECTION CRITERIA
Randomised or quasi-randomised controlled trials, published and unpublished, comparing screening to clinical diagnosis in people with CF.


DATA COLLECTION AND ANALYSIS
Two authors independently assessed trial eligibility and quality and independently extracted data. Allocation concealment was unclear in both studies and sequence generation adequate in one.


MAIN RESULTS
Searches identified six trials. Two trials involving 1,124,483 neonates (210 with CF) with a maximum follow up of 17 years were eligible for inclusion. Varying study designs, outcomes reported and summary measures precluded calculation of pooled estimates and only data from one study were analysed. Severe malnutrition was less common among screened participants. Compared with screened participants, the odds ratio of weight below the tenth percentile was 4.12 (95% CI 1.64 to 10.38) and for height was 4.62 (95% CI 1.69 to 12.61) in the control group.At age seven, 88% of screened participants and 75% of controls had lung function parameters within normal limits of at least 89% predicted. At diagnosis chest radiograph scores were significantly better among screened participants; 33% of screened versus 50% of control participants had Wisconsin chest X-ray (WCXR) scores over five (P = 0.097) and 24% of screened versus 45% of control participants had Brasfield chest X-ray (BCXR) scores under 21 (P = 0.042)). Over time, chest radiograph scores were worse in the screened group (WCXR P = 0.017 and BCXR P = 0.041). Results were no longer significant after adjustment for genotype, pancreatic status, and Pseudomonas aeruginosa-culture results. In screened participants colonisation with Pseudomonas aeruginosa occurred earlier. Estimates suggest diagnosis through screening is less expensive.


AUTHORS' CONCLUSIONS
Two randomised controlled trials assessing neonatal screening in CF were identified; data from one study were included. Nutritional benefits are apparent. Screening provides potential for better pulmonary outcomes, but confounding factors influenced long-term pulmonary prognosis of people with CF. Screening seems less expensive than traditional diagnosis.
MosaicShape: stochastic region grouping with shape prior

A method that combines shape-based object recognition and image segmentation is proposed for shape retrieval from images. Given a shape prior represented in a multi-scale curvature form, the proposed method identifies the target objects in images by grouping oversegmented image regions. The problem is formulated in a unified probabilistic framework, and object segmentation and recognition are accomplished simultaneously by a stochastic Markov Chain Monte Carlo (MCMC) mechanism. Within each sampling move during the simulation process, probabilistic region grouping operations are influenced by both the image information and the shape similarity constraint. The latter constraint is measured by a partial shape matching process. A generalized cluster sampling algorithm is presented in A. Barbu and S. Zhu (2003), combined with a large sampling jump and other implementation improvements, and greatly speeds up the overall stochastic process. The proposed method supports the segmentation and recognition of multiple occluded objects in images. Experimental results are provided for both synthetic and real images.
Clinical course and outcomes of type-2 diabetic patients after treatment intensification for insufficient glycaemic control - results of the 2 year prospective DiaRegis follow-up

BackgroundIn cases where antidiabetic monotherapy is unable to sufficiently control glucose levels in patients with type-2 diabetes, treatment needs to be intensified. Determining factors that may be predictors for the occurrence of comorbidities in these patients is essential for improving the efficacy of clinical diabetes care.MethodsThe DiaRegis prospective cohort study included 3,810 type-2 diabetics for whom the treating physician aimed to intensify and optimise antidiabetic treatment due to insufficient glucose control. Treatment intensification was defined as increasing the dose of the originally prescribed drug, and/or selecting an alternative drug, and/or prescribing an additional drug. The aims were to monitor the co-morbidity burden of type-2 diabetic patients over a follow-up of two years, and to identify multivariable adjusted predictors for the development of comorbidity and cardiovascular events.ResultsA total of 3,058 patients completed the 2 year follow-up. A substantial proportion of these patients had co-morbidities such as vascular disease, neuropathy, and heart failure at baseline. After treatment intensification, there was an increased use of DPP-4 inhibitors, insulin, and GLP-1 analogues, achieving reductions in HbA1c, fasting plasma glucose, and postprandial glucose. During the 2 year period 2.5% of patients (n = 75) died, 3.2% experienced non-fatal macrovascular events, 11.9% experienced microvascular events, and 4.3% suffered onset of heart failure. Predictors for combined macro-/microvascular complications/heart failure/death were found to be age (OR 1.36; 95% CI 1.10–1.68), prior vascular disease (1.73; 1.39–2.16), and history of heart failure (2.78; 2.10–3.68).ConclusionsDetermining the factors that contribute to co-morbidities during intensive glucose-lowering treatment is essential for improving the efficacy of diabetes care. Our results indicate that age, prior vascular disease, and heart failure constitute important predictors of poor cardiovascular outcomes in patients receiving such therapy.
Sexual assault and posttraumatic stress disorder: A review of the biological, psychological and sociological factors and treatments

Sexual assault occurs with alarming frequency in Canada. The prevalence of Posttraumatic Stress Disorder (PTSD) in assault survivors is drastically higher than the national prevalence of the disorder, which is a strong indication that the current therapies for sexual-assault-related PTSD are in need of improvement. Increasing knowledge and understanding of the pathologies associated with rape trauma in biological, psychological and sociological domains will help to develop more effective treatments for survivors. A dysregulation of the Hypothalamic-Pituitary-Adrenal (HPA) axis is observed in survivors of sexual assault and this may be a fundamental cause of the structural and functional abnormalities contributing to PTSD symptoms. Pharmacotherapies are available to treat PTSD; however, they are often inadequate or unwanted by the survivor. Psychological health is compromised following interpersonal trauma and many psychological therapies are available, but with varying efficacy. A person's cognitions have a dramatic effect on the onset, severity, and progress of PTSD following sexual assault. Sociological impacts of assault influence the development of PTSD through victim-blaming attitudes and the perpetuation of rape myths. Perceived positive regard and early social support is shown to be important to successful recovery. Education is vital in rape prevention and to foster a supportive environment for survivors. The biological, psychological and sociological impacts and treatments should not remain mutually exclusive. A better appreciation of the biopsychosocial repercussions of sexual assault will aid in developing a more holistic and individualized therapy to help alleviate the physical and emotional pain following the trauma of rape.
Treatment of acute venous thromboembolism with dabigatran or warfarin and pooled analysis.

BACKGROUND
Dabigatran and warfarin have been compared for the treatment of acute venous thromboembolism (VTE) in a previous trial. We undertook this study to extend those findings.


METHODS AND RESULTS
In a randomized, double-blind, double-dummy trial of 2589 patients with acute VTE treated with low-molecular-weight or unfractionated heparin for 5 to 11 days, we compared dabigatran 150 mg twice daily with warfarin. The primary outcome, recurrent symptomatic, objectively confirmed VTE and related deaths during 6 months of treatment occurred in 30 of the 1279 dabigatran patients (2.3%) compared with 28 of the 1289 warfarin patients (2.2%; hazard ratio, 1.08; 95% confidence interval [CI], 0.64-1.80; absolute risk difference, 0.2%; 95% CI, -1.0 to 1.3; P<0.001 for the prespecified noninferiority margin for both criteria). The safety end point, major bleeding, occurred in 15 patients receiving dabigatran (1.2%) and in 22 receiving warfarin (1.7%; hazard ratio, 0.69; 95% CI, 0.36-1.32). Any bleeding occurred in 200 dabigatran (15.6%) and 285 warfarin (22.1%; hazard ratio, 0.67; 95% CI, 0.56-0.81) patients. Deaths, adverse events, and acute coronary syndromes were similar in both groups. Pooled analysis of this study RE-COVER II and the RE-COVER trial gave hazard ratios for recurrent VTE of 1.09 (95% CI, 0.76-1.57), for major bleeding of 0.73 (95% CI, 0.48-1.11), and for any bleeding of 0.70 (95% CI, 0.61-0.79).


CONCLUSION
Dabigatran has similar effects on VTE recurrence and a lower risk of bleeding compared with warfarin for the treatment of acute VTE.


CLINICAL TRIAL REGISTRATION URL
www.clinicaltrials.gov. Unique identifiers: NCT00680186 and NCT00291330.