LLukas22/scidocs huggingface dataset:
Sensitivity of UHF PD measurements in power transformers

The reliability of electrical energy networks depends on the quality and availability of electrical equipment like power transformers. Local failures inside their insulation may lead to catastrophic breakdowns and might cause high outage and penalty costs. To prevent these destructive events power transformers are e.g. tested for partial discharge (PD) activity before commissioning and currently also during service. The current work deals with the electromagnetic PD detection method, also known as UHF method. The disadvantage of the UHF method is still the missing possibility for a calibration or at least a verification of the sensitivity. The so-called Sensitivity Check might show in future a relation between unconventionally measured UHF quantities to the apparent charge level in pico Coulomb. An important aspect is the attenuation of UHF signals within power transformers which is investigated in this paper.
Triage, decision-making and follow-up of patients referred to a UK forensic service: validation of the DUNDRUM toolkit

BACKGROUND
Forensic medium secure services in the UK are a scarce but essential resource providing care for those in the criminal justice system with severe mental disorder. Appropriate allocation of beds to those most in need is essential to ensure efficient use of this resource. To improve decision-making processes in a UK forensic service, an admissions panel utilized the DUNDRUM 1&2 (D1 & D2) triage instruments.


METHODS
Demographic, diagnostic and clinical information on a prospective sample of referrals to a UK adult forensic service was gathered (n = 195). D1 and D2 measures were scored by a panel of clinical managers considering referral information and clinician opinion in reaching their ratings; those not admitted were also followed up.


RESULTS
Within the sample, D1 ratings were predictive of decisions to admit (AUC = .79) and also differentiated between levels of security (F(4) = 16.54, p < .001). Non-admission was not significantly associated with increased risk of offending at follow-up. Items relating to self-harm and institutional behaviour did not show a predictive relationship with the panel decision to admit.


CONCLUSIONS
Use of a structured professional judgement tool showing good predictive validity has improved transparency of decisions and appears to be associated with more efficient use of resources, without increased risk to the public.
A multi-class SVM classification system based on learning methods from indistinguishable chinese official documents

0957-4174/$ see front matter 2011 Elsevier Ltd. A doi:10.1016/j.eswa.2011.08.176 q This work is supported by NSC, Taiwan, ROC und 194-029-MY2. ⇑ Corresponding author. E-mail addresses: fjh95p@cs.ccu.edu.tw (J. Fu), sin Support Vector Machines (SVM) has been developed for Chinese official document classification in Oneagainst-All (OAA) multi-class scheme. Several data retrieving techniques including sentence segmentation, term weighting, and feature extraction are used in preprocess. We observe that most documents of which contents are indistinguishable make poor classification results. The traditional solution is to add misclassified documents to the training set in order to adjust classification rules. In this paper, indistinguishable documents are observed to be informative for strengthening prediction performance since their labels are predicted by the current model in low confidence. A general approach is proposed to utilize decision values in SVM to identify indistinguishable documents. Based on verified classification results and distinguishability of documents, four learning strategies that select certain documents to training sets are proposed to improve classification performance. Experiments report that indistinguishable documents are able to be identified in a high probability and are informative for learning strategies. Furthermore, LMID that adds both of misclassified documents and indistinguishable documents to training sets is the most effective learning strategy in SVM classification for large set of Chinese official documents in terms of computing efficiency and classification accuracy. 2011 Elsevier Ltd. All rights reserved.
Results of a pivotal phase II study of brentuximab vedotin for patients with relapsed or refractory Hodgkin's lymphoma.

PURPOSE
Brentuximab vedotin is an antibody-drug conjugate (ADC) that selectively delivers monomethyl auristatin E, an antimicrotubule agent, into CD30-expressing cells. In phase I studies, brentuximab vedotin demonstrated significant activity with a favorable safety profile in patients with relapsed or refractory CD30-positive lymphomas.


PATIENTS AND METHODS
In this multinational, open-label, phase II study, the efficacy and safety of brentuximab vedotin were evaluated in patients with relapsed or refractory Hodgkin's lymphoma (HL) after autologous stem-cell transplantation (auto-SCT). Patients had histologically documented CD30-positive HL by central pathology review. A total of 102 patients were treated with brentuximab vedotin 1.8 mg/kg by intravenous infusion every 3 weeks. In the absence of disease progression or prohibitive toxicity, patients received a maximum of 16 cycles. The primary end point was the overall objective response rate (ORR) determined by an independent radiology review facility.


RESULTS
The ORR was 75% with complete remission (CR) in 34% of patients. The median progression-free survival time for all patients was 5.6 months, and the median duration of response for those in CR was 20.5 months. After a median observation time of more than 1.5 years, 31 patients were alive and free of documented progressive disease. The most common treatment-related adverse events were peripheral sensory neuropathy, nausea, fatigue, neutropenia, and diarrhea.


CONCLUSION
The ADC brentuximab vedotin was associated with manageable toxicity and induced objective responses in 75% of patients with relapsed or refractory HL after auto-SCT. Durable CRs approaching 2 years were observed, supporting study in earlier lines of therapy.
Efficacy and safety of ipratropium bromide/albuterol delivered via Respimat inhaler versus MDI.

We compared the efficacy and safety of ipratropium bromide/albuterol delivered via Respimat inhaler, a novel propellant-free inhaler, versus chlorofluorocarbon (CFC)-metered dose inhaler (MDI) and ipratropium Respimat inhaler in patients with COPD. This was a multinational, randomized, double-blind, double-dummy, 12-week, parallel-group, active-controlled study. Patients with moderate to severe COPD were randomized to ipratropium bromide/albuterol (20/100mcg) Respimat inhaler, ipratropium bromide/albuterol MDI [36mcg/206mcg (Combivent Inhalation Aerosol MDI)], or ipratropium bromide (20mcg) Respimat inhaler. Each medication was administered four times daily. Serial spirometry was performed over 6h (0.15min, then hourly) on 4 test days. The primary efficacy variable was forced expiratory volume in 1s (FEV(1)) change from test day baseline at 12 weeks. A total of 1209 of 1480 randomized, treated patients completed the study; the majority were male (65%) with a mean age of 64 yrs and a mean screening pre-bronchodilator FEV(1) (percent predicted) of 41%. Ipratropium bromide/albuterol Respimat inhaler had comparable efficacy to ipratropium bromide/albuterol MDI for FEV(1) area under the curve at 0-6h (AUC(0-6)), superior efficacy to ipratropium Respimat inhaler for FEV(1) AUC(0-4) and comparable efficacy to ipratropium Respimat inhaler for FEV(1) AUC(4-6). All active treatments were well tolerated. This study demonstrates that ipratropium bromide/albuterol 20/100mcg inhaler administered four times daily for 12 weeks had equivalent bronchodilator efficacy and comparable safety to ipratropium bromide/albuterol 36mcg/206mcg MDI, and significantly improved lung function compared with the mono-component ipratropium bromide 20 mcg Respimat inhaler. [Clinical Trial Identifier Number: NCT00400153].
Making the stabilizer ZX-calculus complete for scalars

The ZX-calculus is a graphical language for quantum processes with built-in rewrite rules. The rewrite rules allow equalities to be derived entirely graphically, leading to the question of completeness: can any equality that is derivable using matrices also be derived graphically? The ZX-calculus is known to be complete for scalar-free pure qubit stabilizer quantum mechanics, meaning any equality between two pure stabilizer operators that is true up to a non-zero scalar factor can be derived using the graphical rewrite rules. Here, we replace those scalar-free rewrite rules with correctly scaled ones and show that, by adding one new diagram element and a new rewrite rule, the calculus can be made complete for pure qubit stabilizer quantum mechanics with scalars. This completeness property allows amplitudes and probabilities to be calculated entirely graphically. We also explicitly consider stabilizer zero diagrams, i.e. diagrams that represent a zero matrix, and show that two new rewrite rules suffice to make the calculus complete for those.
Decrease of the atrial fibrillatory rate, increased organization of the atrial rhythm and termination of atrial fibrillation by AZD7009.

BACKGROUND
The atrial fibrillatory rate (AFR), on AZD7009 as compared to placebo, was investigated as a potential biomarker for electrophysiological effect in early antiarrhythmic drug development.


METHODS
Patients with permanent AF received infusions of AZD7009 and placebo in an exploratory two-way, single-blind, randomized cross-over study. The ECG was continuously recorded, and following QRST cancellation the AFR, its standard deviation (SD), the exponential decay and the atrial electrogram amplitude were determined as 3-min averages.


RESULTS
The mean AFR rapidly decreased by 43% from baseline (394 ± 38 to 225 ± 61 fibrillations/min, p=0.0003) on AZD7009, but not on placebo. The SD of the AFR and the exponential decay decreased in parallel. In 2 of 8 patients, termination of AF occurred after the AFR had decreased by 58% and 53%, respectively.


CONCLUSIONS
The AFR may potentially serve as a biomarker of electrophysiological effects in early evaluation of rhythm control agents.
Lignin peroxidase of Phanerochaete chrysosporium. Evidence for an acidic ionization controlling activity.

The active site amino acid residues of lignin peroxidase are homologous to those of other peroxidases; however, in contrast to other peroxidases, no pH dependence is observed for the reaction of ferric lignin peroxidase with H2O2 to form compound I (Andrawis, A., Johnson, K.A., and Tien, M. (1988) J. Biol. Chem. 263, 1195-1198). Chloride binding is used in the present study to investigate this reaction further. Chloride binds to lignin peroxidase at the same site as cyanide and hydrogen peroxide. This is indicated by the following. 1) Chloride competes with cyanide in binding to lignin peroxidase. 2) Chloride is a competitive inhibitor of lignin peroxidase with respect to H2O2. The inhibition constant (Ki) is equal to the dissociation constant (Kd) of chloride at all pH values studied. Chloride binding is pH dependent: chloride binds only to the protonated form of lignin peroxidase. Transient-state kinetic studies demonstrate that chloride inhibits lignin peroxidase compound I formation in a pH-dependent manner with maximum inhibition at low pH. An apparent pKa was calculated at each chloride concentration; the pKa increased as the chloride concentration increased. Extrapolation to zero chloride concentration allowed us to estimate the intrinsic pKa for the ionization in the lignin peroxidase active site. The results reported here provide evidence that an acidic ionizable group (pKa approximately 1) at the active site controls both lignin peroxidase compound I formation and chloride binding. We propose that the mechanism for lignin peroxidase compound I formation is similar to that of other peroxidases in that it requires the deprotonated form of an ionizable group near the active site.
From Cybernetics to Second-Order Cybernetics : A Comparative Analysis of Their Central Ideas

> Context • The enactive paradigm in the cognitive sciences is establishing itself as a strong and comprehensive alternative to the computationalist mainstream. However, its own particular historical roots have so far been largely ignored in the historical analyses of the cognitive sciences. > Problem • In order to properly assess the enactive paradigm’s theoretical foundations in terms of their validity, novelty and potential future directions of development, it is essential for us to know more about the history of ideas that has led to the current state of affairs. > Method • The meaning of the disappearance of the field of cybernetics and the rise of second-order cybernetics is analyzed by taking a closer look at the work of representative figures for each of the phases – Rosenblueth, Wiener and Bigelow for the early wave of cybernetics, Ashby for its culmination, and von Foerster for the development of the second-order approach. > Results • It is argued that the disintegration of cybernetics eventually resulted in two distinct scientific traditions, one going from symbolic AI to modern cognitive science on the one hand, and the other leading from second-order cybernetics to the current enactive paradigm. > Implications • We can now understand that the extent to which the cognitive sciences have neglected their cybernetic parent is precisely the extent to which cybernetics had already carried the tendencies that would later find fuller expression in second-order cybernetics. >
The Roles of Habit, Self-Efficacy, and Satisfaction in Driving Continued Use of Self-Service Technologies: A Longitudinal Study

Recent years have witnessed increased use of self-service technologies (SSTs) across the services sector, which has dramatically changed the nature of the service delivery process. Although an abundance of research has investigated how customers evaluate a new SST and what drives the initial adoption, little is known about how customers interact with, and adapt to, an SST after their first experience. Thus, this study focuses on the dynamic and complex process through which customers move from initial adoption to continued use, after repeated interactions with an SST. A three-wave longitudinal study examines how habit, self-efficacy, and satisfaction affect SST usage over time in a retailing context. The results indicate that as learning occurs and experience accumulates, customers’ continued use of an SST is initially largely rational driven (self-efficacy), then largely emotional driven (satisfaction), and, finally, habitual (habit). Over time, habit completely mediates the impact of intentions on future usage. The article concludes with a discussion of the managerial implications and directions for further research.
No-Needle, Single-Visit Adult Male Circumcision with Unicirc: A Multi-Centre Field Trial

BACKGROUND
Voluntary medical male circumcision (VMMC) is a priority HIV preventive intervention. Current adult circumcision methods need improvement.


METHODS
Field trial in 3 primary care centres. Minimally invasive VMMC using the Unicirc instrument following topical lidocaine/prilocaine anesthetic. Men were followed up at 1 and 4 weeks.


RESULTS
We circumcised 110 healthy volunteers. Two men complained of transient burning pain during circumcision, but none required injectable anaesthesia. Median blood loss was 1ml and median procedure time was 9.0 min. There were 7 (6.3%) moderate complications (5 (4.5%) post-operative bleeds requiring suture and 2 (1.8%) post-operative infections) affecting 7 men. No men experienced significant wound dehiscence. 90.4% of men were fully healed at 4 weeks of follow-up and all were highly satisfied.


CONCLUSIONS
Use of topical anaesthesia obviates the need for injectable anesthetic and makes the Unicirc procedure nearly painless. Unicirc is rapid, easy to learn, heals by primary intention with excellent cosmetic results, obviates the need for a return visit for device removal, and is potentially cheaper and safer than other methods. Use of this method will greatly facilitate scale-up of mass circumcision programs.


TRIAL REGISTRATION
ClinicalTrials.gov NCT02091726.
Effects of β-alanine supplementation and high-intensity interval training on endurance performance and body composition in men; a double-blind trial

BACKGROUND
Intermittent bouts of high-intensity exercise result in diminished stores of energy substrates, followed by an accumulation of metabolites, promoting chronic physiological adaptations. In addition, beta-alanine has been accepted has an effective physiological hydrogen ion (H+) buffer. Concurrent high-intensity interval training (HIIT) and beta-alanine supplementation may result in greater adaptations than HIIT alone. The purpose of the current study was to evaluate the effects of combining beta-alanine supplementation with high-intensity interval training (HIIT) on endurance performance and aerobic metabolism in recreationally active college-aged men.


METHODS
Forty-six men (Age: 22.2 +/- 2.7 yrs; Ht: 178.1 +/- 7.4 cm; Wt: 78.7 +/- 11.9; VO2peak: 3.3 +/- 0.59 l.min-1) were assessed for peak O2 utilization (VO2peak), time to fatigue (VO2TTE), ventilatory threshold (VT), and total work done at 110% of pre-training VO2peak (TWD). In a double-blind fashion, all subjects were randomly assigned into one either a placebo (PL - 16.5 g dextrose powder per packet; n = 18) or beta-alanine (BA - 1.5 g beta-alanine plus 15 g dextrose powder per packet; n = 18) group. All subjects supplemented four times per day (total of 6 g/day) for the first 21-days, followed by two times per day (3 g/day) for the subsequent 21 days, and engaged in a total of six weeks of HIIT training consisting of 5-6 bouts of a 2:1 minute cycling work to rest ratio.


RESULTS
Significant improvements in VO2peak, VO2TTE, and TWD after three weeks of training were displayed (p < 0.05). Increases in VO2peak, VO2TTE, TWD and lean body mass were only significant for the BA group after the second three weeks of training.


CONCLUSION
The use of HIIT to induce significant aerobic improvements is effective and efficient. Chronic BA supplementation may further enhance HIIT, improving endurance performance and lean body mass.
Health co-benefits and risks of public health adaptation strategies to climate change: a review of current literature

Many public health adaptation strategies have been identified in response to climate change. This report reviews current literature on health co-benefits and risks of these strategies to gain a better understanding of how they may affect health. A literature review was conducted electronically using English language literature from January 2000 to March 2012. Of 812 articles identified, 22 peer-reviewed articles that directly addressed health co-benefits or risks of adaptation were included in the review. The co-benefits and risks identified in the literature most commonly relate to improvements in health associated with adaptation actions that affect social capital and urban design. Health co-benefits of improvements in social capital have positive influences on mental health, independently of other determinants. Risks included reinforcing existing misconceptions regarding health. Health co-benefits of urban design strategies included reduced obesity, cardiovascular disease and improved mental health through increased physical activity, cooling spaces (e.g., shaded areas), and social connectivity. Risks included pollen allergies with increased urban green space, and adverse health effects from heat events through the use of air conditioning. Due to the current limited understanding of the full impacts of the wide range of existing climate change adaptation strategies, further research should focus on both unintended positive and negative consequences of public health adaptation.
Electricity from methane by reversing methanogenesis

Given our vast methane reserves and the difficulty in transporting methane without substantial leaks, the conversion of methane directly into electricity would be beneficial. Microbial fuel cells harness electrical power from a wide variety of substrates through biological means; however, the greenhouse gas methane has not been used with much success previously as a substrate in microbial fuel cells to generate electrical current. Here we construct a synthetic consortium consisting of: (i) an engineered archaeal strain to produce methyl-coenzyme M reductase from unculturable anaerobic methanotrophs for capturing methane and secreting acetate; (ii) micro-organisms from methane-acclimated sludge (including Paracoccus denitrificans) to facilitate electron transfer by providing electron shuttles (confirmed by replacing the sludge with humic acids), and (iii) Geobacter sulfurreducens to produce electrons from acetate, to create a microbial fuel cell that converts methane directly into significant electrical current. Notably, this methane microbial fuel cell operates at high Coulombic efficiency.
Dislocation/separation injuries among US high school athletes in 9 selected sports: 2005-2009.

OBJECTIVE
To investigate the epidemiology of dislocations/separations in a nationally representative sample of high school student-athletes participating in 9 sports.


DESIGN
Descriptive epidemiologic study.


SETTING
Sports injury data for the 2005-2009 academic years were collected using an Internet-based injury surveillance system, Reporting Information Online (RIO).


PARTICIPANTS
A nationally representative sample of 100 US high schools.


ASSESSMENT OF RISK FACTORS
Injuries sustained as a function of sport and gender.


MAIN OUTCOME MEASURES
Dislocation/separation rates, body site, outcome, surgery, and mechanism.


RESULTS
Dislocations/separations represented 3.6% (n = 755) of all injuries. The most commonly injured body sites were the shoulder (54.9%), wrist/hand (16.5%), and knee (16.0%); 18.4% of dislocations/separations were recurrences of previous injuries at the same body site; 32.3% of injuries were severe (ie, student-athletes unable to return to play within 3 weeks of the injury date), and 11.8% required surgical repair. The most common mechanisms of injury were contact with another player (52.4%) and contact with the playing surface (26.4%). Injury rates varied by sport. In gender-comparable sports, few variations in patterns of injury existed. Rates were highest in football (2.10 per 10 000 athletic exposures) and wrestling (1.99) and lowest in baseball (0.24) and girls' soccer (0.27).


CONCLUSIONS
Although dislocation/separation injuries represent a relatively small proportion of all injuries sustained by high school student-athletes, the severity of these injuries indicates a need for enhanced injury prevention efforts. Developing effective targeted preventive measures depends on increasing our knowledge of dislocation/separation rates, patterns, and risk factors among high school athletes.