LLukas22/scidocs huggingface dataset:
A hospital-site controlled intervention using audit and feedback to implement guidelines concerning inappropriate treatment of catheter-associated asymptomatic bacteriuria

BACKGROUND
Catheter-associated urinary tract infection (CAUTI) is one of the most common hospital-acquired infections. However, many cases treated as hospital-acquired CAUTI are actually asymptomatic bacteriuria (ABU). Evidence-based guidelines recommend that providers neither screen for nor treat ABU in most catheterized patients, but there is a significant gap between these guidelines and clinical practice. Our objectives are (1) to evaluate the effectiveness of an audit and feedback intervention for increasing guideline-concordant care concerning catheter-associated ABU and (2) to measure improvements in healthcare providers' knowledge of and attitudes toward the practice guidelines associated with the intervention.


METHODS/DESIGN
The study uses a controlled pre/post design to test an intervention using audit and feedback of healthcare providers to improve their compliance with ABU guidelines. The intervention and the control sites are two VA hospitals. For objective 1 we will review medical records to measure the clinical outcomes of inappropriate screening for and treatment of catheter-associated ABU. For objective 2 we will survey providers' knowledge and attitudes. Three phases of our protocol are proposed: the first 12-month phase will involve observation of the baseline incidence of inappropriate screening for and treatment of ABU at both sites. This surveillance for clinical outcomes will continue at both sites throughout the study. Phase 2 consists of 12 months of individualized audit and feedback at the intervention site and guidelines distribution at both sites. The third phase, also over 12 months, will provide unit-level feedback at the intervention site to assess sustainability. Healthcare providers at the intervention site during phase 2 and at both sites during phase 3 will complete pre/post surveys of awareness and familiarity (knowledge), as well as of acceptance and outcome expectancy (attitudes) regarding the relevant practice guidelines.


DISCUSSION
Our proposal to bring clinical practice in line with published guidelines has significant potential to decrease overdiagnosis of CAUTI and associated inappropriate antibiotic use. Our study will also provide information about how to maximize effectiveness of audit and feedback to achieve guideline adherence in the inpatient setting.


TRIAL REGISTRATION
NCT01052545.
Design and Control Principles of Hybrid Braking System for EV, HEV and FCV

Due to the introduction of electrical regenerative braking, the structure, design and control of braking system of an electric vehicle (EV), hybrid electrical vehicle (HEV) and fuel cell vehicle (FCV) is quite different from the pure mechanical braking system of conventional vehicles. Desirable braking performance not only guarantee to quickly stop the vehicle and maintain the traveling direction stable and controllable, but recapture the braking energy as much as possible on various conditions of road. In this paper, the braking energy characteristics on vehicle speed and braking power in typical urban driving cycles have been investigated. The results provide strong supports to the design and control of such hybrid braking system. Two hybrid braking systems have been introduced. One is parallel hybrid braking system, which has a simple structure and control. The other is fully controllable hybrid braking system. Two typical control strategies for this system have been established. One emphasizes optimal braking performance and the other on optimal braking energy recovery.
Characteristics of medication errors with parenteral cytotoxic drugs

Errors involving cytotoxic drugs have the potential of being fatal and should therefore be prevented. The objective of this article is to identify the characteristics of medication errors involving parenteral cytotoxic drugs in Sweden. A total of 60 cases reported to the national error reporting systems from 1996 to 2008 were reviewed. Classification was made to identify cytotoxic drugs involved, type of error, where the error occurred, error detection mechanism, and consequences for the patient. The most commonly involved cytotoxic drugs were fluorouracil, carboplatin, cytarabine and doxorubicin. The platinum-containing drugs often caused serious consequences for the patients. The most common error type were too high doses (45%) followed by wrong drug (30%). Twenty-five of the medication errors (42%) occurred when doctors were prescribing. All of the preparations were delivered to the patient causing temporary or life-threatening harm. Another 25 of the medication errors (42%) started with preparation at the pharmacies. The remaining 10 medication errors (16%) were due to errors during preparation by nurses (5/60) and administration by nurses to the wrong patient (5/60). It is of utmost importance to minimise the potential for errors in the prescribing stage. The identification of drugs and patients should also be improved.
FixMiner: Mining Relevant Fix Patterns for Automated Program Repair

Code comprehension is critical in software maintenance. Towards providing tools and approaches to support maintenance tasks, researchers have investigated various research lines related to how software code can be described in an abstract form. So far, studies on change pattern mining, code clone detection, or semantic patch inference have mainly adopted text-, tokenand tree-based representations as the basis for computing similarity among code fragments. Although, in general, existing techniques form clusters of “similar” code, our experience in patch mining has revealed that clusters of patches formed by such techniques do not usually carry explainable semantics that can be associated to bug-fixing patterns. In this paper, we propose a novel, automated approach for mining semantically-relevant fix patterns based on an iterative, three-fold, clustering strategy. Our technique, FixMiner, leverages different tree representations for each round of clustering: the Abstract syntax tree, the edit actions tree, and the code context tree. We have evaluated FixMiner on thousands of software patches collected from open source projects. Preliminary results show that we are able to mine accurate patterns, efficiently exploiting change information in AST diff trees. Eventually, FixMiner yields patterns which can be associated to the semantics of the bugs that the associated patches address. We further leverage the mined patterns to implement an automated program repair pipeline with which we are able to correctly fix 25 bugs from the Defects4J benchmark. Beyond this quantitative performance, we show that the mined fix patterns are sufficiently relevant to produce patches with a high probability of correctness: 80% of FixMiner’s A. Koyuncu, K. Liu, T. F. Bissyandé, D. Kim, J. Klein, K. Kim, and Y. Le Traon SnT, University of Luxembourg E-mail: {firstname.lastname}@uni.lu M. Monperrus KTH Royal Institute of Technology E-mail: martin.monperrus@csc.kth.se ar X iv :1 81 0. 01 79 1v 1 [ cs .S E ] 3 O ct 2 01 8 2 Anil Koyuncu et al. generated plausible patches are correct, while the closest related works, namely HDRepair and SimFix, achieve respectively 26% and 70% of correctness.
Prostate cancer - evidence of exercise and nutrition trial (PrEvENT): study protocol for a randomised controlled feasibility trial.

BACKGROUND
A growing body of observational evidence suggests that nutritional and physical activity interventions are associated with beneficial outcomes for men with prostate cancer, including brisk walking, lycopene intake, increased fruit and vegetable intake and reduced dairy consumption. However, randomised controlled trial data are limited. The 'Prostate Cancer: Evidence of Exercise and Nutrition Trial' investigates the feasibility of recruiting and randomising men diagnosed with localised prostate cancer and eligible for radical prostatectomy to interventions that modify nutrition and physical activity. The primary outcomes are randomisation rates and adherence to the interventions at 6 months following randomisation. The secondary outcomes are intervention tolerability, trial retention, change in prostate specific antigen level, change in diet, change in general physical activity levels, insulin-like growth factor levels, and a range of related outcomes, including quality of life measures.


METHODS/DESIGN
The trial is factorial, randomising men to both a physical activity (brisk walking or control) and nutritional (lycopene supplementation or increased fruit and vegetables with reduced dairy consumption or control) intervention. The trial has two phases: men are enrolled into a cohort study prior to radical prostatectomy, and then consented after radical prostatectomy into a randomised controlled trial. Data are collected at four time points (cohort baseline, true trial baseline and 3 and 6 months post-randomisation).


DISCUSSION
The Prostate Cancer: Evidence of Exercise and Nutrition Trial aims to determine whether men with localised prostate cancer who are scheduled for radical prostatectomy can be recruited into a cohort and subsequently randomised to a 6-month nutrition and physical activity intervention trial. If successful, this feasibility trial will inform a larger trial to investigate whether this population will gain clinical benefit from long-term nutritional and physical activity interventions post-surgery. Prostate Cancer: Evidence of Exercise and Nutrition Trial (PrEvENT) is registered on the ISRCTN registry, ref number ISRCTN99048944. Date of registration 17 November 2014.
Composable DevOps: Automated Ontology Based DevOps Maturity Analysis

In this era of the emerging digitized, mobilized, and cloudified enterprises, the concept of the "compos able business" is the most critical piece which ties everything together. The digital enterprise is here, and its prime characteristic is that is essentially detaches and segregates existing businesses and reassembles them according to market demands. Every industry, from transportation to eyewear is up for disruption, and developers are in the forefront of this movement. In turn, these developers are under intense pressure to accelerate time to market. The compos able enterprise approach requires a reconsideration of traditional models of the entire IT organization. These organization and their processes need to be broken up into components that follow certain key design principles such as The Minimal Functions with least Dependencies, portability, Shared Knowledge, Predictable Contracts and Maximized Human Value. The last three bullet points encapsulate the very definition of DevOps [3]. The concept of better integration between Development and Operations is a valuable objective. The goal is to foster measurable incremental cultural change to derive most overall value out of the union of people, process and technology. But the cultural issues, reward models, and risk allocation create obvious barriers in attaining those goals. The common industry belief is to use the compos able enterprise framework to build a platform using the right tools and you will have attained DevOps nirvana. In this paper we will explore valuable lessons learned from our mistakes in tool centric adoption of IT Infrastructure Library (ITIL) [8]. We will also show how we applied those lessons to develop a lightweight compos able/contextual DevOps framework that learns and measure itself to avoid those cultural pitfalls.
Left dorsal speech stream components and their contribution to phonological processing.

Models propose an auditory-motor mapping via a left-hemispheric dorsal speech-processing stream, yet its detailed contributions to speech perception and production are unclear. Using fMRI-navigated repetitive transcranial magnetic stimulation (rTMS), we virtually lesioned left dorsal stream components in healthy human subjects and probed the consequences on speech-related facilitation of articulatory motor cortex (M1) excitability, as indexed by increases in motor-evoked potential (MEP) amplitude of a lip muscle, and on speech processing performance in phonological tests. Speech-related MEP facilitation was disrupted by rTMS of the posterior superior temporal sulcus (pSTS), the sylvian parieto-temporal region (SPT), and by double-knock-out but not individual lesioning of pars opercularis of the inferior frontal gyrus (pIFG) and the dorsal premotor cortex (dPMC), and not by rTMS of the ventral speech-processing stream or an occipital control site. RTMS of the dorsal stream but not of the ventral stream or the occipital control site caused deficits specifically in the processing of fast transients of the acoustic speech signal. Performance of syllable and pseudoword repetition correlated with speech-related MEP facilitation, and this relation was abolished with rTMS of pSTS, SPT, and pIFG. Findings provide direct evidence that auditory-motor mapping in the left dorsal stream causes reliable and specific speech-related MEP facilitation in left articulatory M1. The left dorsal stream targets the articulatory M1 through pSTS and SPT constituting essential posterior input regions and parallel via frontal pathways through pIFG and dPMC. Finally, engagement of the left dorsal stream is necessary for processing of fast transients in the auditory signal.
Diagnosis and Anti-Reflux Therapy for GERD with Respiratory Symptoms: A Study Using Multichannel Intraluminal Impedance-pH Monitoring

BACKGROUND/AIMS
Respiratory symptoms are often associated with gastroesophageal reflux disease (GERD). Although the role of multichannel intraluminal impedance-pH (MII-pH) monitoring in GERD is clear, little is known regarding the characteristics of patients with respiratory symptoms based on MII-pH monitoring and anti-reflux therapy. We evaluated a cohort of GERD patients to identify the MII-pH parameters of GERD-related respiratory symptoms and to assess the anti-reflux therapy outcomes.


METHODS
We undertook a prospective study of patients who were referred for GERD evaluation from January 2011 to January 2012. One hundred ninety-five patients underwent MII-pH monitoring and esophageal manometry, and one hundred sixty-five patients underwent invasive anti-reflux therapy that included laparoscopic Toupet fundoplication (LTF) and the Stretta procedure. The patient characteristics and MII-pH parameters were analyzed, and the symptom scores were assessed at baseline and at 1- and 3-year follow-up evaluations.


RESULTS
Of the 195 patients, 96 (49.2%) exhibited respiratory symptoms and significantly more reflux episodes (70.7±29.3) than patients without respiratory symptoms (64.7±24.4, p = 0.044) based on the MII-pH monitoring results. Moreover, the group of patients with respiratory symptoms exhibited more proximal reflux episodes (35.2±21.3) than the non-respiratory symptomatic group (28.3±17.9, p = 0.013). One hundred twenty-five patients following the Stretta procedure (n = 60, 31 with respiratory symptoms) or LTF (n = 65, 35 with respiratory symptoms) completed the designated 3-year follow-up period and were included in the final analysis. The symptom scores after anti-reflux therapy all decreased relative to the corresponding baseline values (p<0.05), and there were no significant differences in the control of respiration between the Stretta procedure and LTF (p>0.05). However, LTF significantly reduced the recurrence (re-operation) rate compared with the Stretta procedure (0 vs. 19.4%, p = 0.006).


CONCLUSIONS
MII-pH monitoring effectively detected respiratory-related predictive parameters, including total/proximal reflux episodes and symptom correlations. We found that GERD patients with respiratory symptoms exhibited more proximal and total reflux episodes but not more acid-related episodes, as determined by MII-pH monitoring. Thus, such monitoring could be useful for diagnosing atypical GERD patients with respiratory symptoms. Furthermore, LTF exhibited a more significant effect on controlling typical symptoms in all GERD patients and reducing the recurrence rate than the Stretta procedure in patients with respiratory symptoms.
Why Total Quality Management Programs Do Not Persist: The Role of Management Quality and Implications for Leading a TQM Transformation

Top-down total quality management (TQM) programs often fail to create deep and sustained change in organizations. They become a fad soon replaced by another fad. Failure to institutionalize TQM can be attributed to a gap between top management’s rhetoric about their intentions for TQM and the reality of implementation in various subunits of the organization. The gap varies from subunit to subunit due to the quality of management in each. By quality of management is meant the capacity of senior team to (1) develop commitment to the new TQM direction and behave and make decisions that are consistent with it, (2) develop the cross-functional mechanisms, leadership skills, and team culture needed for TQM implementation, and (3) create a climate of open dialogues about progress in the TQM transformation that will enable learning and further change. The TQM transformations will persist only if top management requires and ultimately institutionalizes an honest organizational-wide conversation that surfaces valid data about the quality of management in each subunit of the firm and leads to changes in management quality or replacement of managers. Subject Areas: Leadership and Organizational Learning, Organizational Change, Strategy Implementation, and Total Quality Management.
Analysing qos trade-offs in wireless sensor networks

Quality of Service (QoS) support for wireless sensor networks (WSN) is a fairly new topic that is gaining more and more interest. This paper introduces a method for configuring the nodes of a WSN such that application-level QoS constraints are met. This is a complex task, since the search space is typically extremely large. The method is based on a recent algebraic approach to Pareto analysis, that we use to reason about QoS trade-offs. It features an algorithm that keeps the working set of possible configurations small, by analysing parts of the network in a hierarchical fashion, and meanwhile discarding configurations that are inferior to other configurations. Furthermore, we give WSN models for two different applications, in which QoS trade-offs are made explicit. Test results show that the models are accurate and that the method is scalable and thus practically usable for WSN, even with large numbers of nodes.
Apixaban Plus Mono Versus Dual Antiplatelet Therapy in Acute Coronary Syndromes: Insights From the APPRAISE-2 Trial.

BACKGROUND
Bleeding limits anticoagulant treatment in patients with acute coronary syndromes (ACS).


OBJECTIVES
We investigated whether background concomitant antiplatelet therapy influences the effects of apixaban after ACS.


METHODS
This study examined high-risk ACS patients who were treated with aspirin or aspirin plus clopidogrel and who were randomized to apixaban 5 mg twice daily or placebo. In a post-hoc analysis, we assessed whether the effect of apixaban on efficacy and safety outcomes varied by the concomitant antiplatelet regimen by using simple Cox modeling and marginal structural models with propensity scores and antiplatelet therapy as a time-dependent covariate.


RESULTS
At baseline, of 7,364 patients, 16.3% (n = 1,202) were on aspirin alone, and 79.0% (n = 5,814) were on aspirin plus clopidogrel. A total of 19.2% (n = 1,415) switched antiplatelet therapy during follow-up. No differential effect of apixaban versus placebo was observed for the composite endpoint of cardiovascular death, myocardial infarction, and ischemic stroke in patients taking aspirin (12.21 per 100 patient-years vs. 13.21 per 100 patient-years; adjusted hazard ratio [HR]: 0.91; 95% confidence interval [CI]: 0.62 to 1.32) or aspirin plus clopidogrel (13.22 vs. 14.24; adjusted HR: 0.95; 95% CI: 0.78 to 1.14; p(interaction)= 0.84). Compared with placebo, apixaban increased Thrombolysis In Myocardial Infarction major bleeding in patients taking aspirin (1.48 vs. 0.25; adjusted HR: 6.62; 95% CI: 0.75 to 51.73) and in patients taking aspirin plus clopidogrel (2.58 vs. 1.02; adjusted HR: 2.44; 95% CI: 1.34 to 4.45; p(interaction)= 0.41). Similar results were obtained with marginal structural models and in patients treated with and without percutaneous coronary intervention.


CONCLUSIONS
Post-ACS treatment with apixaban versus placebo showed no efficacy, but it increased bleeding regardless of concomitant therapy with aspirin alone or aspirin plus clopidogrel. (Apixaban for Prevention of Acute Ischemic Events 2 [APPRAISE-2]; NCT00831441).
High-level synthesis scheduling and allocation using genetic algorithms

In this article a scheduling method is presented which is capable of allocating supplementary resources during scheduling. This makes it very suitable in synthesis strategies based on lower bound estimations techniques. The method is based on genetic algorithms. Special coding techniques and analysis methods are used to improve the runtime and quality of the results. The scheduler can easily be extended to coverother architectural issues and (for example) providesways to make trade-offs between functional unit allocation and register allocation. Experiments and comparisons show high quality results and fast run times that outperform results produced by other heuristic scheduling methods
Comparison of Fecal Inflammatory Markers in Crohn's Disease.

BACKGROUND
Fecal biomarkers are used increasingly to monitor Crohn's disease (CD). However, the relative accuracy of different markers in identifying inflammation has been poorly evaluated. We evaluated fecal calprotectin (FC), lactoferrin (FL), and S100A12 (FS) using endoscopic validation in a prospective study of the progression of CD after intestinal resection.


METHODS
Data were collected from 135 participants in a prospective, randomized, controlled trial aimed at preventing postoperative CD recurrence. Three hundred nineteen stool samples were tested for FC, FL, and FS preoperatively and 6, 12, and 18 months after resection. Colonoscopy was performed at 6 and/or 18 months. Endoscopic recurrence was assessed blindly using the Rutgeerts score. C-reactive protein (CRP) and Crohn's Disease Activity Index (CDAI) were assessed.


RESULTS
FC, FL, and FS concentrations were elevated preoperatively (median: 1347, 40.9, and 8.4 μg/g, respectively). At 6 months postoperatively, marker concentrations decreased (166, 3.0, 0.9 μg/g) and were higher in recurrent disease than remission (275 versus 72 μg/g, P < 0.001; 5.7 versus 1.6 μg/g, P = 0.007; 2.0 versus 0.8 μg/g, P = 0.188). FC > 135 μg/g, FL > 3.4 μg/g, and FS > 10.5 μg/g indicated endoscopic recurrence (score ≥ i2) with a sensitivity, specificity, and negative predictive value (NPV) of 0.87, 0.66, and 91%; 0.70, 0.68, and 81%; 0.91, 0.12, and 71%, respectively. FC and FL correlated significantly with the presence and severity of endoscopic recurrence, whereas FS, CRP and CDAI did not.


CONCLUSIONS
FC was the optimal fecal marker for monitoring disease activity in postoperative CD and was superior to CRP and CDAI. FL offered modest sensitivity for detecting recurrent disease, whereas S100A12 was sensitive but had low specificity and NPV.