LLukas22/scidocs huggingface dataset:
Cardiac exposures in breast cancer radiotherapy: 1950s-1990s.

PURPOSE
To estimate the doses to the heart and coronary arteries from common breast cancer radiotherapy (RT) regimens used worldwide from the 1950s to the 1990s.


METHODS AND MATERIALS
Virtual simulation and computed tomography planning were used to reconstruct the megavoltage and electron regimens. Manual planning was used for the orthovoltage and brachytherapy regimens. Several sources of variability associated with the dose estimates were assessed.


RESULTS
Breast or chest wall RT resulted in whole heart doses of 0.9-14 Gy for left-sided and of 0.4-6 Gy for right-sided irradiation. Internal mammary chain RT delivered heart doses of 3-17 Gy and 2-10 Gy for left- and right-sided irradiation, respectively. For most regimens, the dose to the left anterior descending coronary artery was greater than the heart dose. Scar boost, supraclavicular fossa, and axillary RT delivered mean cardiac doses of <or=3 Gy. The greatest source of variability in estimating dose from a given regimen was patient anatomy.


CONCLUSION
For most techniques, the greatest radiation doses were received by the anterior part of the heart and the left anterior descending coronary artery, a common site of atherosclerosis causing myocardial infarction. Irradiation of these structures might have contributed to the excess risk of death from heart disease seen after some past breast cancer RT regimens.
Gene expression changes controlling distinct adaptations in the heart and skeletal muscle of a hibernating mammal.

Throughout the hibernation season, the thirteen-lined ground squirrel (Ictidomys tridecemlineatus) experiences extreme fluctuations in heart rate, metabolism, oxygen consumption, and body temperature, along with prolonged fasting and immobility. These conditions necessitate different functional requirements for the heart, which maintains contractile function throughout hibernation, and the skeletal muscle, which remains largely inactive. The adaptations used to maintain these contractile organs under such variable conditions serves as a natural model to study a variety of medically relevant conditions including heart failure and disuse atrophy. To better understand how two different muscle tissues maintain function throughout the extreme fluctuations of hibernation we performed Illumina HiSeq 2000 sequencing of cDNAs to compare the transcriptome of heart and skeletal muscle across the circannual cycle. This analysis resulted in the identification of 1,076 and 1,466 differentially expressed genes in heart and skeletal muscle, respectively. In both heart and skeletal muscle we identified a distinct cold-tolerant mechanism utilizing peroxisomal metabolism to make use of elevated levels of unsaturated depot fats. The skeletal muscle transcriptome also shows an early increase in oxidative capacity necessary for the altered fuel utilization and increased oxygen demand of shivering. Expression of the fetal gene expression profile is used to maintain cardiac tissue, either through increasing myocyte size or proliferation of resident cardiomyocytes, while skeletal muscle function and mass are protected through transcriptional regulation of pathways involved in protein turnover. This study provides insight into how two functionally distinct muscles maintain function under the extreme conditions of mammalian hibernation.
Lessons learnt from SACMEQII: South African student performance in regional context

In regional context, South Africa is well resourced. Its per capita income (adjusted for purchasing power parity) currently ranks third out of the 14 countries surveyed in 2001 for the second wave of the SACMEQ (Southern African Consortium for Monitoring Education Quality) study (World Bank 2004). Further, public spending on education currently constitutes the single largest government budget line item, accounting for approximately 6 per cent of GDP (Republic of South Africa, National Treasury 2004). Given the relative abundance of private and public resources, educationalists and economists alike might be forgiven for predicting that South Africa’s educational outcomes are amongst the best in the region.
Manipulating mitochondrial DNA heteroplasmy by a mitochondrially targeted restriction endonuclease.

Mutations in the mitochondrial DNA (mtDNA) can cause a variety of human diseases. In most cases, such mutations are heteroplasmic (i.e. mutated and wild-type mtDNA coexist) and a small percentage of wild-type sequences can have a strong protective effect against a metabolic defect. Because a genetic approach to correct mtDNA mutations is not currently available, the ability to modulate heteroplasmy would have a major impact in the phenotype of many patients with mitochondrial disorders. We show here that a restriction endonuclease targeted to mitochondria has this ability. A mitochondrially targeted PstI degraded mtDNA harboring PstI sites, in some cases leading to a complete loss of mitochondrial genomes. Recombination between DNA ends released by PstI was not observed. When expressed in a heteroplasmic rodent cell line, containing one mtDNA haplotype with two sites for PstI and another haplotype having none, the mitochondrial PstI caused a significant shift in heteroplasmy, with an accumulation of the mtDNA haplotype lacking PstI sites. These experiments provide proof of the principle that restriction endonucleases are feasible tools for genetic therapy of a sub-group of mitochondrial disorders. Although this approach is limited by the presence of mutation-specific restriction sites, patients with neuropathy, ataxia and retinitis pigmentosa (NARP) could benefit from it, as the T8399G mutation creates a unique restriction site that is not present in wild-type human mitochondrial DNA.
Inequality, Redistribution, and Rent-Seeking

This paper presents a non-median voter model of redistribution in which greater inequality leads to lower redistribution. Bargaining between interest groups and politicians over exemptions implies that individuals with sufficiently high income will not pay taxes in equilibrium. Therefore, voters will set tax rates low enough so as to control the incentives for rent-seeking. An increase in inequality, by putting more income in the hands of individuals that can buy exemptions, will lead to lower equilibrium redistribution. The model can be used to account for a negative relationship between inequality and growth and provides a new explanation of why the poor do not expropriate the rich in democracies.
Falsification Attacks against WPA-TKIP in a Realistic Environment

In this paper, we propose two new falsification attacks against Wi-Fi Protected Access Temporal Key Integrity Protocol (WPATKIP). A previous realistic attack succeeds only for a network that supports IEEE 802.11e QoS features by both an access point (AP) and a client, and it has an execution time of 12–15 min, in which it recovers a message integrity code (MIC) key from an ARP packet. Our first attack reduces the execution time for recovering a MIC key. It can recover the MIC key within 7–8 min. Our second attack expands its targets that can be attacked. This attack focuses on a new vulnerability of QoS packet processing, and this vulnerability can remove the condition that the AP supports IEEE 802.11e. In addition, we discovered another vulnerability by which our attack succeeds under the condition that the chipset of the client supports IEEE 802.11e even if the client disables this standard through the OS. We demonstrate that chipsets developed by several kinds of vendors have the same vulnerability. key words: wireless LAN network, WPA-TKIP, falsification attack, QoS, vulnerability
Diverse and Active Roles for Adipocytes During Mammary Gland Growth and Function

The mammary gland is unique in its requirement to develop in close association with a depot of adipose tissue that is commonly referred to as the mammary fat pad. As discussed throughout this issue, the mammary fat pad represents a complex stromal microenvironment that includes a variety of cell types. In this article we focus on adipocytes as local regulators of epithelial cell growth and their function during lactation. Several important considerations arise from such a discussion. There is a clear and close interrelationship between different stromal tissue types within the mammary fat pad and its adipocytes. Furthermore, these relationships are both stage- and species-dependent, although many questions remain unanswered regarding their roles in these different states. Several lines of evidence also suggest that adipocytes within the mammary fat pad may function differently from those in other fat depots. Finally, past and future technologies present a variety of opportunities to model these complexities in order to more precisely delineate the many potential functions of adipocytes within the mammary glands. A thorough understanding of the role for this cell type in the mammary glands could present numerous opportunities to modify both breast cancer risk and lactation performance.
Increased F3-Isoprostanes in the Canadian Inuit Population Could Be Cardioprotective by Limiting F2-Isoprostane Production.

CONTEXT
F3-isoprostanes (F3-IsoPs), derived from peroxidation of eicosapentaenoic acid (C20:5n-3), could be cardioprotective by limiting production of F2-isoprostanes (F2-IsoPs), a cardiovascular disease risk factor.


OBJECTIVE
The objective of the study was to determine whether the n-3-polyunsaturated (PUFA)-rich Inuit diet is associated with a lower plasma ratio of F2-IsoPs to F3-IsoPs.


DESIGN
This was a cross-sectional observational study.


SETTING
The study was conducted in 36 Canadian Arctic Inuit communities.


PARTICIPANTS
Participants included a random subset (n = 233) of Inuit adults taken from a population-based survey.


MAIN OUTCOME MEASURES
Plasma F2-IsoPs and F3-IsoPs, cardiometabolic risk factors (blood lipids, C-reactive protein, blood pressure, fasting glucose) and markers of dietary exposure (erythrocyte n-3 and n-6 PUFA, blood levels of Se, mercury, polychlorinated biphenyls) were measured.


RESULTS
Inuit aged 40 years old and older vs younger Inuit showed higher concentrations of plasma F3-IsoPs and erythrocyte n-3 PUFA and lower plasma F2-IsoPs concentrations despite having higher blood lipids, fasting glucose, systolic blood pressure, and percentage body fat. Plasma F3-IsoPs were not associated with any cardiometabolic measures. When subjects were categorized into tertiles according to total n-3 PUFA erythrocyte concentrations, F3-IsoPs increased with increasing tertiles, whereas the F2-IsoP to F3-IsoP ratio was lowest at the highest n-3 tertile. The F2-IsoP to F3-IsoP ratio was significantly predicted by C20:5n-3 (β= -.365, P = .002); C20:4n-6:C20:5n-3 (β = .056, P = .006), blood mercury (β = -.812, P =.015), blood Se (β = -1.95, P = .015), and smoking (β = .745, P = .025).


CONCLUSIONS
Plasma F3-IsoPs were not associated with cardiometabolic risk factors previously seen with F2-IsoPs. Higher n-3 fatty acid status was associated with lower plasma F2-IsoPs and higher plasma F3-IsoPs, which provides partial explanation to the cardioprotective effects of the n-3 PUFA-rich Inuit diet.
Self-Supervised GAN to Counter Forgetting

GANs involve training two networks in an adversarial game, where each network’s task depends on its adversary. Recently, several works have framed GAN training as an online or continual learning problem [1–6]. We focus on the discriminator, which must perform classification under an (adversarially) shifting data distribution. When trained on sequential tasks, neural networks exhibit forgetting. For GANs, discriminator forgetting leads to training instability [1]. To counter forgetting, we encourage the discriminator to maintain useful representations by adding a self-supervision. Conditional GANs have a similar effect using labels. However, our self-supervised GAN does not require labels, and closes the performance gap between conditional and unconditional models. We show that, in doing so, the self-supervised discriminator learns better representations than regular GANs.
A High Gain Rectangular Microstrip Patch Antenna Using "Different C Patterns" Metamaterial Design in L-Band

Design of rectangular microstrip patch antenna loaded with “different C patterns” left-handed metamaterial structure has been proposed. The proposed metamaterial structure is designed at a height of 3.2 mm from the ground plane for L-band (1 GHz-2 GHz) applications. The most interesting feature of the design is the ability of enhancing the gain and total efficiency of the antenna without effecting the other important parameters like bandwidth and directivity. The double negative (DNG) properties of metamaterial (−μ and −ε) have been proved by simulated S parameters. By using the “different C patterns” metamaterial structure, the return loss of the rectangular microstrip patch antenna is significantly reduced by 24 dB at a resonating frequency of 2 GHz. The proposed antenna is most suitable for wireless local area network (WLAN) application operating at 2 GHz.
Cutaneous lupus erythematosus: issues in diagnosis and treatment.

Cutaneous lupus erythematosus (LE) may present in a variety of clinical forms. Three recognized subtypes of cutaneous LE are acute cutaneous LE (ACLE), subacute cutaneous LE (SCLE), and chronic cutaneous LE (CCLE). ACLE may be localized (most often as a malar or 'butterfly' rash) or generalized. Multisystem involvement as a component of systemic LE (SLE) is common, with prominent musculoskeletal symptoms. SCLE is highly photosensitive, with predominant distribution on the upper back, shoulders, neck, and anterior chest. SCLE is frequently associated with positive anti-Ro antibodies and may be induced by a variety of medications. Classic discoid LE is the most common form of CCLE, with indurated scaly plaques on the scalp, face, and ears, with characteristic scarring and pigmentary change. Less common forms of CCLE include hyperkeratotic LE, lupus tumidus, lupus profundus, and chilblain lupus. Common cutaneous disease associated with, but not specific for, LE includes vasculitis, livedo reticularis, alopecia, digital manifestations such as periungual telangiectasia and Raynaud phenomenon, photosensitivity, and bullous lesions. The clinical presentation of each of these forms, their diagnosis, and the inter-relationships between cutaneous LE and SLE are discussed. Common systemic findings in SLE are reviewed, as are diagnostic strategies, including histopathology, immunopathology, serology, and other laboratory findings. Treatments for cutaneous LE initially include preventive (e.g. photoprotective) strategies and topical therapies (corticosteroids and topical calcineurin inhibitors). For skin disease not controlled with these interventions, oral antimalarial agents (most commonly hydroxychloroquine) are often beneficial. Additional systemic therapies may be subdivided into conventional treatments (including corticosteroids, methotrexate, thalidomide, retinoids, dapsone, and azathioprine) and newer immunomodulatory therapies (including efalizumab, anti-tumor necrosis factor agents, intravenous immunoglobulin, and rituximab). We review evidence for the use of these medications in the treatment of cutaneous LE.
Which cognitive abilities underlie computational thinking? Criterion validity of the Computational Thinking Test

Computational thinking (CT) is being located at the focus of educational innovation, as a set of problemsolving skills that must be acquired by the new generations of students to thrive in a digital world full of objects driven by software. However, there is still no consensus on a CT definition or how to measure it. In response, we attempt to address both issues from a psychometric approach. On the one hand, a Computational Thinking Test (CTt) is administered on a sample of 1,251 Spanish students from 5th to 10th grade, so its descriptive statistics and reliability are reported in this paper. On the second hand, the criterion validity of the CTt is studied with respect to other standardized psychological tests: the Primary Mental Abilities (PMA) battery, and the RP30 problem-solving test. Thus, it is intended to provide a new instrument for CT measurement and additionally give evidence of the nature of CT through its associations with key related psychological constructs. Results show statistically significant correlations at least moderately intense between CT and: spatial ability (r 1⁄4 0.44), reasoning ability (r 1⁄4 0.44), and problemsolving ability (r 1⁄4 0.67). These results are consistent with recent theoretical proposals linking CT to some components of the Cattel-Horn-Carroll (CHC) model of intelligence, and corroborate the conceptualization of CT as a problem-solving ability. © 2016 Elsevier Ltd. All rights reserved.
Coronary sinus ostium in the lateral right atrium: Implications for the electrophysiologist

Introduction The coronary sinus (CS) is a critical structure that has helped aid electrophysiologists by providing information about epicardial activation along the mitral annulus. Additionally, the advent of biventricular pacing utilizes the CS venous system for lead placement. The CS collects the venous drainage of the atrial and ventricular venous branches and drains into the right atrium (RA). CS anomalies have been recognized, namely atresia of the CS ostium, unroofed CS, connection with the left atrium, and even hypoplasia of the CS. We report 3 cases of CS ostium opening in the midlateral RA. This anomaly may provide new insight into the development of the CS as well as provide an explanation for difficult cannulation of the CS.
The Hawthorne Effect: a randomised, controlled trial

BACKGROUND
The 'Hawthorne Effect' may be an important factor affecting the generalisability of clinical research to routine practice, but has been little studied. Hawthorne Effects have been reported in previous clinical trials in dementia but to our knowledge, no attempt has been made to quantify them. Our aim was to compare minimal follow-up to intensive follow-up in participants in a placebo controlled trial of Ginkgo biloba for treating mild-moderate dementia.


METHODS
Participants in a dementia trial were randomised to intensive follow-up (with comprehensive assessment visits at baseline and two, four and six months post randomisation) or minimal follow-up (with an abbreviated assessment at baseline and a full assessment at six months). Our primary outcomes were cognitive functioning (ADAS-Cog) and participant and carer-rated quality of life (QOL-AD).


RESULTS
We recruited 176 participants, mainly through general practices. The main analysis was based on Intention to treat (ITT), with available data. In the ANCOVA model with baseline score as a co-variate, follow-up group had a significant effect on outcome at six months on the ADAS-Cog score (n = 140; mean difference = -2.018; 95%CI -3.914, -0.121; p = 0.037 favouring the intensive follow-up group), and on participant-rated quality of life score (n = 142; mean difference = -1.382; 95%CI -2.642, -0.122; p = 0.032 favouring minimal follow-up group). There was no significant difference on carer quality of life.


CONCLUSION
We found that more intensive follow-up of individuals in a placebo-controlled clinical trial of Ginkgo biloba for treating mild-moderate dementia resulted in a better outcome than minimal follow-up, as measured by their cognitive functioning.


TRIAL REGISTRATION
Current controlled trials: ISRCTN45577048.
Multiclass Learnability and the ERM principle

We study the sample complexity of multiclass prediction in several learning settings. For the PAC setting our analysis reveals a surprising phenomenon: In sharp contrast to binary classification, we show that there exist multiclass hypothesis classes for which some Empirical Risk Minimizers (ERM learners) have lower sample complexity than others. Furthermore, there are classes that are learnable by some ERM learners, while other ERM learners will fail to learn them. We propose a principle for designing good ERM learners, and use this principle to prove tight bounds on the sample complexity of learning symmetric multiclass hypothesis classes—classes that are invariant under permutations of label names. We further provide a characterization of mistake and regret bounds for multiclass learning in the online setting and the bandit setting, using new generalizations of Littlestone’s dimension.
Challenges in the diagnosis of fetal non-chromosomal abnormalities at 11-13 weeks.

OBJECTIVE
To examine the performance of the 11-13 weeks scan in detecting non-chromosomal abnormalities.


METHODS
Prospective first-trimester screening study for aneuploidies, including basic examination of the fetal anatomy, in 45 191 pregnancies. Findings were compared to those at 20-23 weeks and postnatal examination.


RESULTS
Aneuploidies (n = 332) were excluded from the analysis. Fetal abnormalities were observed in 488 (1.1%) of the remaining 44 859 cases; 213 (43.6%) of these were detected at 11-13 weeks. The early scan detected all cases of acrania, alobar holoprosencephaly, exomphalos, gastroschisis, megacystis and body stalk anomaly, 77% of absent hand or foot, 50% of diaphragmatic hernia, 50% of lethal skeletal dysplasias, 60% of polydactyly, 34% of major cardiac defects, 5% of facial clefts and 14% of open spina bifida, but none of agenesis of the corpus callosum, cerebellar or vermian hypoplasia, echogenic lung lesions, bowel obstruction, most renal defects or talipes. Nuchal translucency (NT) was above the 95th percentile in 34% of fetuses with major cardiac defects.


CONCLUSION
At 11-13 weeks some abnormalities are always detectable, some can never be and others are potentially detectable depending on their association with increased NT, the phenotypic expression of the abnormality with gestation and the objectives set for such a scan.
Vibration Control of Flexible-link Manipulators

In this paper, vibration control of flexible-link manipulators is considered. A nonlinear partial differential equation describing the dynamics of a two-link planar manipulator with a flexible forearm is derived. The zero-dynamics of a rigid/flex (hybrid) manipulator are given. Thereafter, different controllers are synthesized. The controller design strategies are based upon an inner-loop controller which corresponds to the rigid body motion of the manipulator taking into consideration the vibrations of the manipulator and an outer-loop controller for further vibration damping and robustness enhancement of the closed-loop dynamics to parameter variations in the system. The measurements used in the outer-loop controller are obtained through accelerometer and strain gages mounted on the flexible forearm. The control methodologies advocated in this paper are applicable to the multi-link flexible manipulators.