LLukas22/scidocs huggingface dataset:
Periodontal healing by periodontal ligament cell sheets in a teeth replantation model.

OBJECTIVE
Successful transplantation of avulsed teeth is to restore the attachment and regenerate the periodontal support. Different strategies have been applied in treatment from modification of teeth storage, antibiotic usage to peridontium tissue replacement. We developed a novel periodontal ligament cell-sheet delivery system to apply on delayed replanted teeth in promoting periodontal healing in a canine model.


DESIGN
Autologous periodontal ligament (PDL) fibroblasts were isolated from extracted premolars of beagle dog. The cell-sheets were fabricated using normal culture dish after stimulation of extracellular matrix formation. Teeth were surgically extracted and attached soft tissues were removed. After root canal treatment, the root of teeth were wrapped by the PDL cell-sheets and replanted back to prior socket accordingly whilst teeth without cell sheets as a control. Eight weeks after surgery, the animals were sacrificed and decalcified specimens were prepared. Regeneration of periodontal tissue was evaluated through histology assay.


RESULTS
Multi-layered PDL cell-sheet could be attached on tooth root and most cells on sheet-tooth constructs were viable before replantation. Minimum clinical signs of inflammation were observed in experiment. PDL cell-sheets group show significant higher occurrence of favourable healing (88.4%) than control group with low healing (5.3%). Periodontal ligament and cememtum tissue regeneration was observed in the experimental group, and the regenerated tissues showed high collagen type III, type I and fibronectin expression.


CONCLUSION
The periodontal ligament cell-sheets fabricated through normal cell culture dish has a potential for regeneration of periodontal ligament and may become a novel therapy for avulsed teeth replantation.
Priming Pharyngeal Motor Cortex by Repeated Paired Associative
Stimulation

BACKGROUND
Several stimulation parameters can influence the neurophysiological and behavioral effects of paired associative stimulation (PAS), a neurostimulation paradigm that repeatedly pairs a peripheral electrical with a central cortical (transcranial magnetic stimulation [TMS]) stimulus. This also appears to be the case when PAS is applied to the pharyngeal motor cortex (MI), with some variability in excitatory responses, questioning its translation into a useful therapy for patients with brain injury.


OBJECTIVE
To investigate whether repeated PAS in both "responders" and "nonresponders" could enhance cortical excitability in pharyngeal MI more robustly.


METHODS
Based on their responses after single PAS, healthy participants were stratified into 2 groups of "responders" and "nonresponders" and underwent 2 periods (60 minutes inter-PAS interval) of active and sham PAS in a randomized order. Neurophysiological measurements with single TMS pulses from pharyngeal motor representation were collected up to 90 minutes after the second PAS period.


RESULTS
Repeated PAS increased cortical excitability up to 95% at 60 minutes following the second PAS in both the "responders" and "nonresponders." Moreover, cortical excitability in the "nonresponders" was significantly different after repeated PAS compared with single and sham application (P = .02; z = -2.2).


CONCLUSIONS
Double dose PAS switched "nonresponders" to "responders." These results are important for PAS application to dysphagic stroke patients who do not initially respond to a single application.
Attention Based LSTM for Target Dependent Sentiment Classification

We present an attention-based bidirectional LSTM approach to improve the target-dependent sentiment classification. Our method learns the alignment between the target entities and the most distinguishing features. We conduct extensive experiments on a real-life dataset. The experimental results show that our model achieves state-of-the-art results.
New beginnings, continued success

In his first EIC message as D&T's new editor in chief, Tim Cheng notes that D&T has developed strong relationships with key electronic-design and test communities over the past several years. Such partnerships help to broaden the readership and further strengthen D&T's position as the leading magazine for the professional design, test, and design automation communities.
Breast cancer in elderly women: a different reality? Results from the NORA study.

BACKGROUND
The incidence of breast cancer increases with age, and the disease affects many older women; however, attitudes about prevention and treatment of breast cancer vary based on the patient's age. Older women have less access to clinical trials and fewer opportunities for treatment with innovative therapies. The National Oncological Research observatory on Adjuvant therapy in breast cancer (NORA) study was a cohort study designed to obtain information about adjuvant strategies for treatment of breast cancer after surgery, patterns of recurrence, and possible correlations between cancer-related events and biological factors.


PATIENTS AND METHODS
This report describes patient characteristics, disease status, and local and systemic adjuvant treatments in a population of breast cancer patients aged >or=65 years. The NORA study consecutively enrolled >3500 patients from 2000 through 2002 at 77 Italian hospitals; of these, 1085 were aged >or=65 years. Data on patient characteristics, cancer presentation, and treatments were analyzed to identify possible relationships between these factors and age.


RESULTS
The findings indicate that age is significantly related to later diagnosis and different patterns of treatment. Choice of adjuvant systemic treatment was primarily related to hormone receptor status and tumor stage but was strongly influenced by the patient's age; there was a proportional relationship between endocrine treatment and increasing age. Cyclophosphamide, methotrexate, and 5-fluorouracil as well as anthracyclines were widely used, but the use of taxanes was limited to a very small percentage of patients.


CONCLUSIONS
The findings of the NORA study may help to change attitudes that currently exclude a significant proportion of breast cancer patients from secondary prevention policies, more active treatment strategies, and clinical research trials based on age.
Male involvement in sexual and reproductive health in the Mendi district, Southern Highlands province of Papua New Guinea: a descriptive study

BACKGROUND
Lack of male involvement and support for sexual and reproductive health services is seen by many Papua New Guinean women as a barrier to accessing services. Poor utilization of services by both men and women is reflected in high maternal mortality and high rates of HIV/AIDS and sexually transmitted infections in the Southern Highlands Province. It is therefore important to understand the type of services provided, men's perceptions of these services and the Health Sector's capacity to involve men in its programs.


METHODS
Information from interviews of married men, officers in charge of health facilities, and information from a focus group discussion with village leaders was collected to assess possible constraints to reproductive and sexual health care delivery.


RESULTS
Although many men had heard about antenatal care, supervised births, family planning and sexually transmitted infections including, HIV/AIDS, many were unaware of their importance and of the types of services provided to address these issues. There was a very strong association between men's literacy and their knowledge of Sexual and Reproductive Health (SRH) issues, their discussion of these issues with their wives and their wives' utilisation of sexual and reproductive health services. Some men considered SRH services to be important but gave priority to social obligations. Although men made most decisions for sexual and reproductive issues, pregnancy, child birth and rearing of children were regarded as women's responsibilities. Knowledge of HIV/AIDS appeared to have changed sexual behaviour in some men. Services for men in this rural setting were inadequate and service providers lacked the capacity to involve men in reproductive health issues.


CONCLUSION
Poor knowledge, socio-cultural factors and inadequate and inappropriate services for men hampered utilization of services and impaired support for their wives' service utilization. Programmatic and policy initiatives should focus on improving service delivery to accommodate men in sexual and reproductive health.
Procrastination of Enjoyable

of Management, University of California, Los Angeles (e-mail: suzanne. shu@anderson.ucla.edu). Ayelet Gneezy is Assistant Professor of Marketing, Rady School of Management, University of California, San Diego (e-mail: agneezy@ucsd.edu). This article is based in part on Suzanne Shu’s doctoral dissertation. The authors thank the excellent JMR review team; Gal Zauberman; and dissertation committee members Richard Thaler, George Wu, Yuval Rottenstreich, and France Leclerc for their insightful comments and guidance. They also thank Alessandro Pevitero, the Museum of Contemporary Art in San Diego, the French Pastry Café, and AMC Theaters for providing data. Dilip Soman served as associate editor for this article. SUZANNE B. SHU and AYELET GNEEZY*
High dielectric constant in CaCu/sub 3/Ti/sub 4/O/sub 12/ multiphased ceramics

Different CCT powders containing several phases, CaCu/sub 3/Ti/sub 4/O/sub 12/ (major phase), CaTiO/sub 3/ and CuO are elaborated by a "soft chemistry" method. Three main types of sintered ceramics are realized: a monophased consisting of the pure CCT phase, a biphased (CCT + CaTiO/sub 3/), and a three-phased (CCT + CaTiO/sub 3/ + copper oxide (CuO or Cu/sub 2/O)). All of them present original dielectric properties. Values up to 8 /spl times/ 10/sup 5/ at 1 kHz are obtained for the relative permittivity with relatively low losses. The origin of such huge permittivity values and the influence of the structure (presence of additional phases) on the dielectric properties of the ceramics are discussed.
A Model of Prefrontal Cortical Mechanisms for Goal-directed Behavior

Many behavioral tasks require goal-directed actions to obtain delayed reward. The prefrontal cortex appears to mediate many aspects of goal-directed decision making. This article presents a model of prefrontal cortex function emphasizing the influence of goal-related activity on the choice of the next motor output. The model can be interpreted in terms of key elements of Reinforcement Learning Theory. Different neocortical minicolumns represent distinct sensory input states and distinct motor output actions. The dynamics of each minicolumn include separate phases of encoding and retrieval. During encoding, strengthening of excitatory connections forms forward and reverse associations between each state, the following action, and a subsequent state, which may include reward. During retrieval, activity spreads from reward states throughout the network. The interaction of this spreading activity with a specific input state directs selection of the next appropriate action. Simulations demonstrate how these mechanisms can guide performance in a range of goal-directed tasks, and provide a functional framework for some of the neuronal responses previously observed in the medial prefrontal cortex during performance of spatial memory tasks in rats.
Estimation of road profile for vehicle dynamics motion: Experimental validation

Knowledge of vehicle dynamic data is essential for the enhancement of active safety systems such as suspensions and trajectory control systems. Vehicle controllability analysis on real roads can be obtained only if valid road profile and tire road friction model are known. With regard to the road profile, this study focuses on a real-time estimation method based on Kalman filter. Besides, this paper presents a method for calculating loads on the wheels using road profile. The proposed method is based on the dynamic response of a vehicle instrumented with available sensors. The estimation process is applied and compared to real experimental data obtained with two inertial methods in real conditions. Experimental results show the accuracy and the potential of the proposed estimation process.
Numerical Simulation of Low Mach Number Reactive Flows

A new formulation for the numerical solution of low Mach number compressible flow problems is presented and analyzed. In this formulation the thermal part (energy and species equations) is solved implicitly and decoupled from the momentum equation, whereas the hydrodynamic part (momentumcontinuity) is advanced in time using a high order splitting approach which results in overall high order accuracy in time and minimal errors in mass conservation. These errors are analyzed using both analytical tools and benchmark numerical examples. Results from two-dimensional simulations with one-step global reaction in opposed jet flame and porous particle configurations are also presented.
Radiographic predictors for maxillary canine impaction.

INTRODUCTION
The aims of this study were to compare 3-dimensional cone-beam computed tomography (CBCT) images of patients with unilaterally impacted canines and to determine the possible radiographic factors for prediction of maxillary canine impactions.


METHODS
The sample consisted of 65 patients ranging in age from 9.6 to 13.8 years. The patients comprised 43 girls and 22 boys, with a mean age of 12.1 years and a median age of 12.2 years (±SD 1.23 years). Of the impacted maxillary canines, 32 were located on the right side and 33 on the left side. CBCT radiography was available for all patients. The diagnosis of a unilaterally impacted canine was determined from the patients' dental records as a unilateral failure of the canine to erupt at its appropriate site in the dental arch in contrast to normal eruption of the contralateral side. Radiographic follow-up assessment to identify unilateral impaction was performed for 1 year. The radiographic variables generated and the specific features investigated were collected with 3-dimensional CBCT imaging and compared between the impacted and the contralateral maxillary canines.


RESULTS
Statistically significant differences were found between the impacted and nonimpacted canines. Based on these results, clinical relevance and correlations among the variables-canine rotation, canine crown position, canine cusp tip to the midline and to the occlusal plane, canine angle to the midline, and canine angle to the lateral incisor-were considered as variables in a multivariable prediction model. A prediction model using CBCT for canine impaction was established (area under the curve, 0.965; 95% confidence interval, 0.936 to 0.995). Canine crown position, canine cusp tip to the occlusal plane, and canine angulation to the lateral incisor were the relevant predictors in this model.


CONCLUSIONS
Prediction of canine impaction based on CBCT was excellent. The probability of canine impaction obtained from the prediction model can help orthodontists to define the optimal intervention method.
Early effect on general interest, and short-term antidepressant efficacy and safety of agomelatine (25-50mg/day) and escitalopram (10-20mg/day) in outpatients with Major Depressive Disorder. A 12-week randomised double-blind comparative study.

BACKGROUND
A double-blind, randomized, study was conducted in 29 centers in Romania to evaluate the effect of agomelatine 25-50mg/day (n=144 patients) on general interest, overall clinical efficacy, and functionality in comparison with escitalopram 10-20mg/day (n=143 patients) in out-patients diagnosed with moderate to severe Major Depressive Disorder (MDD).


METHODS
The primary endpoint of the study was the score difference between agomelatine and escitalopram were assessed on the item 13 of the Quick Inventory of Depressive Symptomatology (16-Item) Self-Report (QIDS-SR16) over the first week period. Secondary measures include the primary criterion on the 12-week period, the within-group evolution over 12 weeks of the 17-item Hamilton Depression Scale (HAM-D17) total score, CGI severity of illness (CGI-S) and CGI-I scores, and functionality by using the self-rated Sheehan Disability Scale (SDS).


RESULTS
After one week, the mean General Interest score showed no statistically significant difference between treatments. Over 12 weeks, patients felt more and more interested in other people and activities than before having taken medication. Both agomelatine and escitalopram improved depressive symptoms and symptom-related functional impairment of patients. Both agomelatine and escitalopram were well-tolerated by patients.


LIMITATIONS
The strength of our results would benefit from additional data from trials using a similar design and other active comparators.


CONCLUSION
There was no difference in week 1 changes of interest between agomelatine and escitalopram. The relatively good tolerability of agomelatine and escitalopram is confirmed.
Efficacy of a behavioral self-help treatment with or without therapist guidance for co-morbid and primary insomnia -a randomized controlled trial

BACKGROUND
Cognitive behavioral therapy is treatment of choice for insomnia, but availability is scarce. Self-help can increase availability at low cost, but evidence for its efficacy is limited, especially for the typical insomnia patient with co-morbid problems. We hypothesized that a cognitive behaviorally based self-help book is effective to treat insomnia in individuals, also with co-morbid problems, and that the effect is enhanced by adding brief therapist telephone support.


METHODS
Volunteer sample; 133 media-recruited adults with insomnia. History of sleep difficulties (mean [SD]) 11.8 [12.0] years. 92.5% had co-morbid problems (e.g. allergy, pain, and depression). Parallel randomized (block-randomization, n ≥ 21) controlled "open label" trial; three groups-bibliotherapy with (n = 44) and without (n = 45) therapist support, and waiting list control (n = 44). Assessments before and after treatment, and at three-month follow-up. Intervention was six weeks of bibliotherapeutic self-help, with established cognitive behavioral methods including sleep restriction, stimulus control, and cognitive restructuring. Therapist support was a 15-minute structured telephone call scheduled weekly. Main outcome measures were sleep diary data, and the Insomnia Severity Index.


RESULTS
Intention-to-treat analyses of 133 participants showed significant improvements in both self-help groups from pre to post treatment compared to waiting list. For example, treatment with and without support gave shorter sleep onset latency (improvement minutes [95% Confidence Interval], 35.4 [24.2 to 46.6], and 20.6 [10.6 to 30.6] respectively), and support gave a higher remission rate (defined as ISI score below 8; 61.4%), than bibliotherapy alone (24.4%, p's < .001). Improvements were not seen in the control group (sleep onset latency 4.6 minutes shorter [-1.5 to 10.7], and remission rate 2.3%). Self-help groups maintained gains at three-month follow-up.


CONCLUSIONS
Participants receiving self-help for insomnia benefited markedly. Self-help, especially if therapist-supported, has considerable potential to be as effective as individual treatment at lower cost, also for individuals with co-morbid problems.


TRIAL REGISTRATION
ClinicalTrials.gov: NCT01105052.
Code2Vec: Embedding and Clustering Medical Diagnosis Data

Identifying disease comorbidities and grouping medical diagnoses into disease incidents are two important problems in health care delivery and assessment. Using vector space embeddings produced using the Global Vectors (GloVe) algorithm, we are able to find useful vector representations of diagnosis codes that can identify related diagnoses and thus improve identification of related disease incidents.
Day-to-day measurement of patient-reported outcomes in exacerbations of chronic obstructive pulmonary disease

BACKGROUND
Exacerbations of chronic obstructive pulmonary disease (COPD) are a major burden to patients and to society. Little is known about the possible role of day-to-day patient-reported outcomes during an exacerbation. This study aims to describe the day-to-day course of patient-reported health status during exacerbations of COPD and to assess its value in predicting clinical outcomes.


METHODS
Data from two randomized controlled COPD exacerbation trials (n = 210 and n = 45 patients) were used to describe both the feasibility of daily collection of and the day-to-day course of patient-reported outcomes during outpatient treatment or admission to hospital. In addition to clinical parameters, the BORG dyspnea score, the Clinical COPD Questionnaire (CCQ), and the St George's Respiratory Questionnaire were used in Cox regression models to predict treatment failure, time to next exacerbation, and mortality in the hospital study.


RESULTS
All patient-reported outcomes showed a distinct pattern of improvement. In the multivariate models, absence of improvement in CCQ symptom score and impaired lung function were independent predictors of treatment failure. Health status and gender predicted time to next exacerbation. Five-year mortality was predicted by age, forced expiratory flow in one second % predicted, smoking status, and CCQ score. In outpatient management of exacerbations, health status was found to be less impaired than in hospitalized patients, while the rate and pattern of recovery was remarkably similar.


CONCLUSION
Daily health status measurements were found to predict treatment failure, which could help decision-making for patients hospitalized due to an exacerbation of COPD.
The Top Chinese Mobile Health Apps: A Systematic Investigation

BACKGROUND
China's mHealth market is on track to become a global leader by industry size. The Chinese mobile app market and health care system have peculiarities that distinguish them from other app markets. To date, Chinese mHealth apps have not been systematically investigated.


OBJECTIVE
The objective of this study was to provide an overview of Chinese mHealth apps as of December 2015.


METHODS
We identified and investigated the most downloaded apps from the iOS and Android platforms. For each app, we analyzed and recorded its main service offered, mHealth initiative, disease and specialty focus, app cost, target user, Web app availability, and emphasis on information security. Standard descriptive statistics were used.


RESULTS
A total of 234 apps met the inclusion criteria and were investigated. The apps targeting nonhealth care professionals focused on providing telemedicine and appointment-making services. The apps targeting health care professionals focused on education and peer reviewed articles. The most common disease-specific apps focused primarily on diabetes, hypertension, and hepatitis management. Most apps were free and available on both iOS and Android platforms.


CONCLUSIONS
The primary mHealth initiatives targeted by the apps reflect Chinese patients' demand for access to medical care. Disease-specific apps are also representative of disease prevalence in China. Government press releases suggest that new policies on the horizon may shift the industry.