LLukas22/scidocs huggingface dataset:
The More Electric Aircraft: Technology and challenges.

The More Electric Aircraft concept offers many potential benefits in the design and efficiency of future large, manned aircraft. In this article, typical aircraft electrical power systems and associated loads are described as well as the exciting future challenges for the aerospace industry. The importance of power electronics as an enabling technology for this step change in aircraft design is considered, and examples of typical system designs are discussed.
Nightmare Abbey/Crotchet Castle

Two 19th-century novels satirize romanticism, political theories, and society through witty dialogue.
Comparison of vildagliptin twice daily vs. sitagliptin once daily using continuous glucose monitoring (CGM): Crossover pilot study (J-VICTORIA study)

BACKGROUND
No previous studies have compared the DPP-4 inhibitors vildagliptin and sitagliptin in terms of blood glucose levels using continuous glucose monitoring (CGM) and cardiovascular parameters.


METHODS
Twenty patients with type 2 diabetes mellitus were randomly allocated to groups who received vildagliptin then sitagliptin, or vice versa. Patients were hospitalized at 1 month after starting each drug, and CGM was used to determine: 1) mean (± standard deviation) 24-hour blood glucose level, 2) mean amplitude of glycemic excursions (MAGE), 3) fasting blood glucose level, 4) highest postprandial blood glucose level and time, 5) increase in blood glucose level after each meal, 6) area under the curve (AUC) for blood glucose level ≥180 mg/dL within 3 hours after each meal, and 7) area over the curve (AOC) for daily blood glucose level <70 mg/dL. Plasma glycosylated hemoglobin (HbA1c), glycoalbumin (GA), 1,5-anhydroglucitol (1,5AG), immunoreactive insulin (IRI), C-peptide immunoreactivity (CPR), brain natriuretic peptide (BNP), and plasminogen activator inhibitor-1 (PAI-1) levels, and urinary CPR levels, were measured.


RESULTS
The mean 24-hour blood glucose level was significantly lower in patients taking vildagliptin than sitagliptin (142.1 ± 35.5 vs. 153.2 ± 37.0 mg/dL; p = 0.012). In patients taking vildagliptin, MAGE was significantly lower (110.5 ± 33.5 vs. 129.4 ± 45.1 mg/dL; p = 0.040), the highest blood glucose level after supper was significantly lower (206.1 ± 40.2 vs. 223.2 ± 43.5 mg/dL; p = 0.015), the AUC (≥180 mg/dL) within 3 h was significantly lower after breakfast (484.3 vs. 897.9 mg/min/dL; p = 0.025), and urinary CPR level was significantly higher (97.0 ± 41.6 vs. 85.2 ± 39.9 μg/day; p = 0.008) than in patients taking sitagliptin. There were no significant differences in plasma HbA1c, GA, 1,5AG, IRI, CPR, BNP, or PAI-1 levels between patients taking vildagliptin and sitagliptin.


CONCLUSIONS
CGM showed that mean 24-h blood glucose, MAGE, highest blood glucose level after supper, and hyperglycemia after breakfast were significantly lower in patients with type 2 diabetes mellitus taking vildagliptin than those taking sitagliptin. There were no significant differences in BNP and PAI-1 levels between patients taking vildagliptin and sitagliptin.


TRIAL REGISTRATION
UMIN000007687.
Home-based, early intervention with mechatronic toys for preterm infants at risk of neurodevelopmental disorders (CARETOY): a RCT protocol

BACKGROUND
Preterm infants are at risk for neurodevelopmental disorders, including motor, cognitive or behavioural problems, which may potentially be modified by early intervention. The EU CareToy Project Consortium (http://www.caretoy.eu) has developed a new modular system for intensive, individualized, home-based and family-centred early intervention, managed remotely by rehabilitation staff. A randomised controlled trial (RCT) has been designed to evaluate the efficacy of CareToy training in a first sample of low-risk preterm infants.


METHODS/DESIGN
The trial, randomised, multi-center, evaluator-blinded, parallel group controlled, is designed according to CONSORT Statement. Eligible subjects are infants born preterm without major complications, aged 3-9 months of corrected age with specific gross-motor abilities defined by Ages & Stages Questionnaire scores. Recruited infants, whose parents will sign a written informed consent for participation, will be randomized in CareToy training and control groups at baseline (T0). CareToy group will perform four weeks of personalized activities with the CareToy system, customized by the rehabilitation staff. The control group will continue standard care. Infant Motor Profile Scale is the primary outcome measure and a total sample size of 40 infants has been established. Bayley-Cognitive subscale, Alberta Infants Motor Scale and Teller Acuity Cards are secondary outcome measures. All measurements will be performed at T0 and at the end of training/control period (T1). For ethical reasons, after this first phase infants enrolled in the control group will perform the CareToy training, while the training group will continue standard care. At the end of open phase (T2) all infants will be assessed as at T1. Further assessment will be performed at 18 months corrected age (T3) to evaluate the long-term effects on neurodevelopmental outcome. Caregivers and rehabilitation staff will not be blinded whereas all the clinical assessments will be performed, videotaped and scored by blind assessors. The trial is ongoing and it is expected to be completed by April 2015.


DISCUSSION
This paper describes RCT methodology to evaluate CareToy as a new tool for early intervention in preterm infants, first contribution to test this new type of system. It presents background, hypotheses, outcome measures and trial methodology.


TRIAL REGISTRATION
ClinicalTrials.gov: NCT01990183. EU grant ICT-2011.5.1-287932.
Predictors of resistance to preoperative trastuzumab and vinorelbine for HER2-positive early breast cancer.

PURPOSE
To assess pathologic complete response (pCR), clinical response, feasibility, safety, and potential predictors of response to preoperative trastuzumab plus vinorelbine in patients with operable, human epidermal growth factor receptor 2 (HER2)-positive breast cancer.


EXPERIMENTAL DESIGN
Forty-eight patients received preoperative trastuzumab and vinorelbine weekly for 12 weeks. Single and multigene biomarker studies were done in an attempt to identify predictors of response.


RESULTS
Eight of 40 (20%) patients achieved pCR (95% confidence interval, 9-36%). Of 9 additional patients recruited for protocol-defined toxicity analysis, 8 were evaluable; 42 of 48 (88%) patients had clinical response (16 patients, clinical complete response; 26 patients, clinical partial response). T(1) tumors more frequently exhibited clinical complete response (P = 0.05) and showed a trend to exhibit pCR (P = 0.07). Five (13%) patients experienced grade 1 cardiac dysfunction during preoperative treatment. Neither HER2 nor estrogen receptor status changed significantly after exposure to trastuzumab and vinorelbine. RNA profiling identified three top-level clusters by unsupervised analysis. Tumors with extremes of response [pCR (n = 3) versus nonresponse (n = 3)] fell into separate groups by hierarchical clustering. No predictive genes were identified in pCR tumors. Nonresponding tumors were more likely to be T(4) stage (P = 0.02) and express basal markers (P < 0.00001), growth factors, and growth factor receptors. Insulin-like growth factor-I receptor membrane expression was associated with a lower response rate (50% versus 97%; P = 0.001).


CONCLUSIONS
Preoperative trastuzumab plus vinorelbine is active and well tolerated in patients with HER2-positive, operable, stage II/III breast cancer. HER2-overexpressing tumors with a basal-like phenotype, or with expression of insulin-like growth factor-I receptor and other proteins involved in growth factor pathways, are more likely to be resistant to this regimen.
Leucocyte classification for leukaemia detection using image processing techniques

INTRODUCTION
The counting and classification of blood cells allow for the evaluation and diagnosis of a vast number of diseases. The analysis of white blood cells (WBCs) allows for the detection of acute lymphoblastic leukaemia (ALL), a blood cancer that can be fatal if left untreated. Currently, the morphological analysis of blood cells is performed manually by skilled operators. However, this method has numerous drawbacks, such as slow analysis, non-standard accuracy, and dependences on the operator's skill. Few examples of automated systems that can analyse and classify blood cells have been reported in the literature, and most of these systems are only partially developed. This paper presents a complete and fully automated method for WBC identification and classification using microscopic images.


METHODS
In contrast to other approaches that identify the nuclei first, which are more prominent than other components, the proposed approach isolates the whole leucocyte and then separates the nucleus and cytoplasm. This approach is necessary to analyse each cell component in detail. From each cell component, different features, such as shape, colour and texture, are extracted using a new approach for background pixel removal. This feature set was used to train different classification models in order to determine which one is most suitable for the detection of leukaemia.


RESULTS
Using our method, 245 of 267 total leucocytes were properly identified (92% accuracy) from 33 images taken with the same camera and under the same lighting conditions. Performing this evaluation using different classification models allowed us to establish that the support vector machine with a Gaussian radial basis kernel is the most suitable model for the identification of ALL, with an accuracy of 93% and a sensitivity of 98%. Furthermore, we evaluated the goodness of our new feature set, which displayed better performance with each evaluated classification model.


CONCLUSIONS
The proposed method permits the analysis of blood cells automatically via image processing techniques, and it represents a medical tool to avoid the numerous drawbacks associated with manual observation. This process could also be used for counting, as it provides excellent performance and allows for early diagnostic suspicion, which can then be confirmed by a haematologist through specialised techniques.
Isotope approach to assess hydrologic connections during Marcellus Shale drilling.

Water and gas samples were collected from (1) nine shallow groundwater aquifers overlying Marcellus Shale in north-central West Virginia before active shale gas drilling, (2) wells producing gas from Upper Devonian sands and Middle Devonian Marcellus Shale in southwestern Pennsylvania, (3) coal-mine water discharges in southwestern Pennsylvania, and (4) streams in southwestern Pennsylvania and north-central West Virginia. Our preliminary results demonstrate that the oxygen and hydrogen isotope composition of water, carbon isotope composition of dissolved inorganic carbon, and carbon and hydrogen isotope compositions of methane in Upper Devonian sands and Marcellus Shale are very different compared with shallow groundwater aquifers, coal-mine waters, and stream waters of the region. Therefore, spatiotemporal stable isotope monitoring of the different sources of water before, during, and after hydraulic fracturing can be used to identify migrations of fluids and gas from deep formations that are coincident with shale gas drilling.
Relationships of methacholine and adenosine monophosphate responsiveness with serum vascular endothelial growth factor in children with asthma.

BACKGROUND
Airway hyperresponsiveness, which is a characteristic feature of asthma, is usually measured by means of bronchial challenge with direct or indirect stimuli. Vascular endothelial growth factor (VEGF) increases vascular permeability and angiogenesis, leads to mucosal edema, narrows the airway diameter, and reduces airway flow.


OBJECTIVE
To examine the relationships between serum VEGF level and airway responsiveness to methacholine and adenosine monophosphate (AMP) in children with asthma.


METHODS
Peripheral blood eosinophil counts, serum eosinophil cationic protein (ECP) concentrations, and serum VEGF concentrations were measured in 31 asthmatic children and 26 control subjects. Methacholine and AMP bronchial challenges were performed on children with asthma.


RESULTS
Children with asthma had a significantly higher mean (SD) level of VEGF than controls (361.2 [212.0] vs 102.7 [50.0] pg/mL; P < .001). Blood eosinophil counts and serum ECP levels significantly correlated inversely with AMP provocation concentration that caused a decrease in forced expiratory volume in 1 second of 20% (PC20) (r = -0.474, P =.01; r = -0.442, P =.03, respectively), but not with methacholine PC20 (r = -0.228, P = .26; r = -0.338, P =.10, respectively). Serum VEGF levels significantly correlated with airway responsiveness to AMP (r = -0.462; P = .009) but not to methacholine (r = -0.243; P = .19).


CONCLUSIONS
Serum VEGF levels were increased in children with asthma and were related to airway responsiveness to AMP but not to methacholine. Increased VEGF levels in asthmatic children may result in increased airway responsiveness by mechanisms related to airway inflammation or increased permeability of airway vasculature.
An Automatic Controller Extractor for HDL Descriptions at the RTL

ern circuit designs, verification has become the major bottleneck in the entire design process.1 To cope with the exponential state-space growth, researchers have proposed some techniques2,3 to reduce this state space in functional verification at the register transfer level (RTL). Because most design errors are related to the design’s control part, one possible solution is to separate the data paths from the controllers and verify the control part only. However, in the proposed techniques, the capability of extracting controllers relies on specific control-register labels, which users must assign manually. In large designs, labeling the hundreds of control registers is inconvenient. More importantly, if the original designers are not available—for example, when using vendor-provided intellectual property—assigning labels becomes very difficult. In modern designs, almost all controllers consist of finite-state machines (FSMs). Therefore, by locating the FSMs, we can find the possible locations of controllers. Some vendors claim their tools4 can automatically extract FSMs in the original hardware description language (HDL) code. However, most of these tools depend on a specific coding style or user intervention. The literature offers some approaches for translating HDL code into FSMs by compiler techniques.5,6 As we know, a compiler translates predefined language constructs into other forms. Therefore, compiler-based approaches must also limit users’ coding styles. It can be difficult to deal with real designs from various designers with varying coding styles. To overcome the problems of existing approaches, we propose a novel method for extracting FSMs in HDL code written at the RTL by recognizing the general patterns of FSMs in the process-module (PM) graph. These general patterns are derived from the relationship between an FSM’s current states and its next states, not the language constructs. Therefore, the writing style of HDL code is almost entirely unrestricted. Hints or comments in the source code aren’t needed either. We already reported on the preliminary stage of this work.7 The reported experimental results on several real designs from different designers with various coding styles have shown the effectiveness and efficiency of our algorithm. Because we use the general FSM patterns in the recognition process, some special designs, such as the program counters and the accumulators used in arithmetic logic, may be identified as general FSMs. Although these have general FSM structures, they are in fact only An Automatic Controller Extractor for HDL Descriptions at the RTL Automatic Controller Extractor
Façade: An Experiment in Building a Fully-Realized Interactive Drama

Contemporary games are making significant strides towards offering complex, immersive experiences for players. We can now explore sprawling 3D virtual environments populated by beautifully rendered characters and objects with autonomous behavior, engage in highly visceral action-oriented experiences offering a variety of missions with multiple solutions, and interact in ever-expanding online worlds teeming with physically customizable player avatars.
FLAG-IDA in the treatment of refractory/relapsed acute myeloid leukemia: single-center experience

 We evaluated the efficacy and toxicity profiles of the combination of fludarabine, high-dose cytosine arabinoside (AraC), idarubicin, and granulocyte colony-stimulating factor (G-CSF) in refractory/relapsed acute myeloblastic leukemia (AML) patients. Between October 1998 and February 2002, 46 AML patients were treated with FLAG-IDA (fludarabine 30 mg/m2, AraC 2 g/m2 for 5 days, idarubicin 10 mg/m2 for 3 days, and G-CSF 5 µg/kg from day +6 until neutrophil recovery). Thirty patients were in relapse after conventional chemotherapy including cytarabine, etoposide, and daunorubicin or mitoxantrone according to the GIMEMA protocols. Four were in relapse after autologous peripheral stem cell transplantation and two after allogeneic bone marrow transplantation. Ten patients had refractory disease (after 10 days of standard doses of cytarabine, 3 days of mitoxantrone or daunorubicin, and 5 days of etoposide). Recovery of neutrophils and platelets required a median of 19 and 22 days from the start of therapy. Complete remission (CR) was obtained in 24 of 46 patients (52.1%) and 3 of 46 (6.6%) died during reinduction therapy: 2 due to cerebral hemorrhage and 1 due to fungemia (Candida tropicalis). Fever >38.5°C was observed in 40 of 46 patients (86.9%), 27 had fever of unknown origin (FUO) and 13 documented infections; 31 of 46 (67.3%) developed mucositis and 14 of 46 (30.4%) had grade 2 WHO transient liver toxicity. After achieving CR, 11 patients received allogeneic stem cell transplantation, 4 patients received autologous stem cell transplantation, 4 were judged unable to receive any further therapy, and 5 refused other therapy. Ten patients are at present in continuous CR after a median follow-up of 13 months (range: 4–24). In our experience, FLAG-IDA is a well-tolerated and effective regimen in relapsed/refractory AML. The toxicity is acceptable, enabling most patients to receive further treatment, including transplantation procedures.
After the origin of life

SummaryAs to the primary morphogenesis which occurred after the origin of life, two conditions are considered.(a)It must be a non-specific pattern.(b)It must be one of the simplest patterns.
The above conditions are satisfied by the morphogenetic polarity. Actually, the simplest polar pattern is divided into two classes. The first of these is represented by a regional protrusion of the surface of a sphere (Fig. 1B), and the second by a regional inversion (Fig. 1C). That means that the first morphogenesis might take place towards two directions: regional protrusion and regional inversion of the globular organism. Both of them might be conditioned by the appearance of protoplasmic polarity.
A Trajectory-Based Ball Tracking Framework with Visual Enrichment for Broadcast Baseball Videos

Pitching contents play the key role in the resultant victory or defeat in a baseball game. Utilizing the physical characteristic of ball motion, this paper presents a trajectory-based framework for automatic ball tracking and pitching evaluation in broadcast baseball videos. The task of ball detection and tracking in broadcast baseball videos is very challenging because in video frames, the noises may cause many ball-like objects, the ball size is small, and the ball may deform due to its high speed movement. To overcome these challenges, we first define a set of filters to prune most non-ball objects but retain the ball, even if it is deformed. In ball position prediction and trajectory extraction, we analyze the 2D distribution of ball candidates and exploit the characteristic that the ball trajectory presents in a near parabolic curve in video frames. Most of the non-qualified trajectories are pruned, which greatly improves the computational efficiency. The missed balls can also be recovered in the trajectory by applying the position prediction. The experiments of ball tracking on the testing sequences of JPB, MLB and CPBL captured from different TV channels show promising results. The ball tracking framework is able to extract the ball trajectory, superimposed on the video, and in near real-time provide visual enrichment before the next pitch coming up without specific cameras or equipments set up in the stadiums. It can also be utilized in strategy analysis and intelligence statistics for player training.
Rhinoplasty for Middle Eastern noses.

BACKGROUND
Rhinoplasty remains one of the most challenging operations, as exemplified in the Middle Eastern patient. The ill-defined, droopy tip, wide and high dorsum, and thick skin envelope mandate meticulous attention to preoperative evaluation and efficacious yet safe surgical maneuvers. The authors provide a systematic approach to evaluation and improvement of surgical outcomes in this patient population.


METHODS
A retrospective, 3-year review identified patients of Middle Eastern heritage who underwent primary rhinoplasty and those who did not but had nasal photographs. Photographs and operative records (when applicable) were reviewed. Specific nasal characteristics, component-directed surgical techniques, and aesthetic outcomes were delineated.


RESULTS
The Middle Eastern nose has a combination of specific nasal traits, with some variability, including thick/sebaceous skin (excess fibrofatty tissue), high/wide dorsum with cartilaginous and bony humps, ill-defined nasal tip, weak/thin lateral crura relative to the skin envelope, nostril-tip imbalance, acute nasolabial and columellar-labial angles, and a droopy/hyperdynamic nasal tip. An aggressive yet nondestructive surgical approach to address the nasal imbalance often requires soft-tissue debulking, significant cartilaginous framework modification (with augmentation/strengthening), tip refinement/rotation/projection, low osteotomies, and depressor septi nasi muscle treatment. The most common postoperative defects were related to soft-tissue scarring, thickened skin envelope, dorsum irregularities, and prolonged edema in the supratip/tip region.


CONCLUSIONS
It is critical to improve the strength of the cartilaginous framework with respect to the thick, noncontractile skin/soft-tissue envelope, particularly when moderate to large dorsal reduction is required. A multitude of surgical maneuvers are often necessary to address all the salient characteristics of the Middle Eastern nose and to produce the desired aesthetic result.
Query-biased learning to rank for real-time twitter search

By incorporating diverse sources of evidence of relevance, learning to rank has been widely applied to real-time Twitter search, where users are interested in fresh relevant messages. Such approaches usually rely on a set of training queries to learn a general ranking model, which we believe that the benefits brought by learning to rank may not have been fully exploited as the characteristics and aspects unique to the given target queries are ignored. In this paper, we propose to further improve the retrieval performance of learning to rank for real-time Twitter search, by taking the difference between queries into consideration. In particular, we learn a query-biased ranking model with a semi-supervised transductive learning algorithm so that the query-specific features, e.g. the unique expansion terms, are utilized to capture the characteristics of the target query. This query-biased ranking model is combined with the general ranking model to produce the final ranked list of tweets in response to the given target query. Extensive experiments on the standard TREC Tweets11 collection show that our proposed query-biased learning to rank approach outperforms strong baseline, namely the conventional application of the state-of-the-art learning to rank algorithms.