LLukas22/scidocs huggingface dataset:
What Makes a Neural Code Convex

Neural codes allow the brain to represent, process, and store information about the world. Combinatorial codes, comprised of binary patterns of neural activity, encode information via the collective behavior of populations of neurons. A code is called convex if its codewords correspond to regions defined by an arrangement of convex open sets in Euclidean space. Convex codes have been observed experimentally in many brain areas, including sensory cortices and the hippocampus, where neurons exhibit convex receptive fields. What makes a neural code convex? That is, how can we tell from the intrinsic structure of a code if there exists a corresponding arrangement of convex open sets? In this work, we provide a complete characterization of local obstructions to convexity. This motivates us to define max intersection-complete codes, a family guaranteed to have no local obstructions. We then show how our characterization enables one to use free resolutions of Stanley-Reisner ideals in order to detect violations of convexity. Taken together, these results provide a significant advance in understanding the intrinsic combinatorial properties of convex codes.
Surface-passivated GaAsP single-nanowire solar cells exceeding 10% efficiency grown on silicon.

Continued development of high-efficiency multi-junction solar cells requires growth of lattice-mismatched materials. Today, the need for lattice matching both restricts the bandgap combinations available for multi-junctions solar cells and prohibits monolithic integration of high-efficiency III-V materials with low-cost silicon solar cells. The use of III-V nanowires is the only known method for circumventing this lattice-matching constraint, and therefore it is necessary to develop growth of nanowires with bandgaps >1.4 eV. Here we present the first gold-free gallium arsenide phosphide nanowires grown on silicon by means of direct epitaxial growth. We demonstrate that their bandgap can be controlled during growth and fabricate core-shell nanowire solar cells. We further demonstrate that surface passivation is of crucial importance to reach high efficiencies, and present a record efficiency of 10.2% for a core-shell single-nanowire solar cell.
Hashing-Based Approximate Probabilistic Inference in Hybrid Domains

In recent years, there has been considerable progress on fast randomized algorithms that approximate probabilistic inference with tight tolerance and confidence guarantees. The idea here is to formulate inference as a counting task over an annotated propositional theory, called weighted model counting (WMC), which can be partitioned into smaller tasks using universal hashing. An inherent limitation of this approach, however, is that it only admits the inference of discrete probability distributions. In this work, we consider the problem of approximating inference tasks for a probability distribution defined over discrete and continuous random variables. Building on a notion called weighted model integration, which is a strict generalization of WMC and is based on annotating Boolean and arithmetic constraints, we show how probabilistic inference in hybrid domains can be put within reach of hashing-based WMC solvers. Empirical evaluations demonstrate the applicability and promise of the proposal.
Criticality of detailed modeling in semiconductor supply chain simulation

Supply chain management offers a large potential for organizations to reduce costs and improve customer service performance. Simulation of supply chains can help in these objectives by evaluating the impact of alternate inventory control policies. Supply chain simulation involves modeling of multiple factories across the chain and can get quite complex. Analysts typically carry out such simulation at a coarse level of detail to keep the complexity and computing resources manageable. However, modeling at coarse levels may reduce the accuracy of outputs and affect the quality of decisions. In this paper, we report on a study to compare the quality of results at different levels of details in a semiconductor supply chain simulation.
A possibilistic approach to selecting portfolios with highest utility score

The mean–variance methodology for the portfolio selection problem, originally proposed by Markowitz, has been one of the most important research ,elds in modern ,nance. In this paper we will assume that: (i) each investor can assign a welfare, or utility, score to competing investment portfolios based on the expected return and risk of the portfolios; and (ii) the rates of return on securities are modelled by possibility distributions rather than probability distributions. We will present an algorithm of complexity o(n) for ,nding an exact optimal solution (in the sense of utility scores) to the n-asset portfolio selection problem under possibility distributions. c © 2001 Elsevier Science B.V. All rights reserved.
Recovery of the blood pressure – cerebral flow relation after carotid stenting in elderly patients

Background. As a sensitive and convenient means for the cerebral hemodynamic monitoring, dynamic cerebral autoregulation testing could be especially useful in medical conditions where less invasive diagnostics and therapies are preferred. This study analysed the effect of carotid stenting on dynamic autoregulation in elderly patients focussing on the relation between blood pressure and cerebral blood flow velocity. Methods. We examined 20 patients age 69 ± 8 years with coexisting cerebrovascular and medical risk factors before and at least six month after stenting of severe carotid stenoses. Data were compared to 24 age-matched healthy controls. Slow spontaneous oscillations were studied in continuous recordings of Transcranial Doppler and beat-to-beat blood pressure. Analysis was based on the “high-pass filter model”, which predicts a positive phase relationship between these oscillations. Findings. Whereas phase shift angles were diminished (20.4 ± 14.1°) before stenting, after stenting these values were significantly increased to normal (48.1 ± 16.6°), to the level of controls (46.7 ± 15.9°). Medical conditions such as coronary artery disease, arterial hypertension, and dyslipidemia did not diminish this recovery. The level of increase was inversely correlated with the initial autoregulatory deficit (r = −0.68) which was largest with insufficient collateral blood supply and symptomatic carotid stenoses. Conclusions. The study showed that an impaired cerebral autoregulation may recover after stent-guided carotid angioplasty even in the elderly with co-existing medical conditions. In this respect to regain vasomotor capability, patients with cerebrovascular risk factors seemed to benefit particularly.
Maternal Valacyclovir and Infant Cytomegalovirus Acquisition: A Randomized Controlled Trial among HIV-Infected Women

BACKGROUND
Studies in HIV-1-infected infants and HIV-1-exposed, uninfected infants link early cytomegalovirus (CMV) acquisition with growth delay and cognitive impairment. We investigated maternal valacyclovir to delay infant acquisition of CMV.


METHODS
Pregnant women with HIV-1, HSV-2 and CD4 count >250 cells/µl were randomized at 34 weeks gestation to 500 mg twice-daily valacyclovir or placebo for 12 months. Maternal CMV DNA was measured in plasma at 34 weeks gestation, in cervical secretions at 34 and 38 weeks gestation, and in breast milk at 7 postpartum timepoints; infant CMV DNA was measured in dried blood spots at 8 timepoints including birth.


RESULTS
Among 148 women, 141 infants were compared in intent-to-treat analyses. Maternal and infant characteristics were similar between study arms. Infant CMV acquisition did not differ between study arms, with 46/70 infants (66%) in placebo arm and 47/71 infants (66%) in the valacyclovir arm acquiring CMV; median time to CMV detection did not differ. CMV DNA was detected in 92% of 542 breast milk specimens with no difference in CMV level between study arms. Change in cervical shedding of CMV DNA between baseline and 38 weeks was 0.40-log greater in the placebo arm than the valacyclovir arm (p = 0.05).


CONCLUSIONS
In this cohort of HIV-1-seropositive mothers, two-thirds of infants acquired CMV by one year. Maternal valacyclovir had no effect on timing of infant CMV acquisition or breast milk CMV viral loads, although it modestly reduced cervical CMV shedding. Maternal prophylaxis to reduce infant CMV acquisition warrants further evaluation in trials with antiviral agents.


TRIALS REGISTRATION
ClinicalTrials.gov NCT00530777.
Modeling and Detection of Hotspot in Shaded Photovoltaic Cells

In this paper, we address the problem of modeling the thermal behavior of photovoltaic (PV) cells undergoing a hotspot condition. In case of shading, PV cells may experience a dramatic temperature increase, with consequent reduction of the provided power. Our model has been validated against experimental data, and has highlighted a counterintuitive PV cell behavior, that should be considered to improve the energy efficiency of PV arrays. Then, we propose a hotspot detection scheme, enabling to identify the PV module that is under hotspot condition. Such a scheme can be used to avoid the permanent damage of the cells under hotspot, thus their drawback on the power efficiency of the entire PV system.
Inside case-based explanation

Case-Based Reasoning (CBR) is a rapidly growing eld in AI. It is a memorydriven approach to problem solving; completed solutions to problems are stored in an `episodic' memory, retrieved and adaptively applied to solve new problems. \Inside Case-based Reasoning" [4], the popular predecessor to this book, is a well written introductory text for the subject. This book is an attempt to expand the theory of CBR from a problem solving technique to a model of cognition. The main philosophical claim is that CaseBased Explanation (CBE) underlies understanding and learning (p21):
Depressive symptoms and menopausal burden in the midlife.

OBJECTIVE
The goal of this study was to assess whether menopausal symptoms were more common and/or more severe among women with depressive symptoms.


METHODS
A cross-sectional survey of 1358 women, ages 45-70, at two large integrated health plans (Seattle; Boston) was performed. Information on demographics, medical and reproductive history, medication use, menopausal experience and depressive symptoms (PHQ-8) were collected. Women taking HT were excluded. Logistic regression models adjusted for age and body mass index tested the associations between menopausal symptoms (hot flushes, night sweats, vaginal dryness and dyspareunia) and presence of moderate/severe depressive symptoms.


RESULTS
770 women were included; 98 (12.7%) had moderate/severe depressive symptoms and 672 (87.3%) had no/mild depressive symptoms. Women with moderate/severe depressive symptoms were almost twice as likely to report recent vasomotor symptoms (hot flashes and or night sweats) vs. women with no/mild depressive symptoms (adjusted odds ratio (aOR) 1.67, 95%CI 1.04-2.68), and to report them as severe (aOR 1.63, 95%CI 0.95-2.83). A higher symptom burden was observed despite the fact that 20% of women with moderate/severe depressive symptoms (vs. 4.6% no/mild depressive symptoms) were using an SSRI or SNRI, medications known to improve vasomotor symptoms. The percentage of women with menopausal symptoms, and the percentage with severe vasomotor symptoms were linearly associated with the depressive symptom score.


CONCLUSIONS
Depressive symptoms "amplified" the menopausal experience, or alternatively, severe vasomotor symptoms worsened depressive symptoms.
Ranibizumab and bevacizumab for neovascular age-related macular degeneration.

BACKGROUND
Clinical trials have established the efficacy of ranibizumab for the treatment of neovascular age-related macular degeneration (AMD). In addition, bevacizumab is used off-label to treat AMD, despite the absence of similar supporting data.


METHODS
In a multicenter, single-blind, noninferiority trial, we randomly assigned 1208 patients with neovascular AMD to receive intravitreal injections of ranibizumab or bevacizumab on either a monthly schedule or as needed with monthly evaluation. The primary outcome was the mean change in visual acuity at 1 year, with a noninferiority limit of 5 letters on the eye chart.


RESULTS
Bevacizumab administered monthly was equivalent to ranibizumab administered monthly, with 8.0 and 8.5 letters gained, respectively. Bevacizumab administered as needed was equivalent to ranibizumab as needed, with 5.9 and 6.8 letters gained, respectively. Ranibizumab as needed was equivalent to monthly ranibizumab, although the comparison between bevacizumab as needed and monthly bevacizumab was inconclusive. The mean decrease in central retinal thickness was greater in the ranibizumab-monthly group (196 μm) than in the other groups (152 to 168 μm, P=0.03 by analysis of variance). Rates of death, myocardial infarction, and stroke were similar for patients receiving either bevacizumab or ranibizumab (P>0.20). The proportion of patients with serious systemic adverse events (primarily hospitalizations) was higher with bevacizumab than with ranibizumab (24.1% vs. 19.0%; risk ratio, 1.29; 95% confidence interval, 1.01 to 1.66), with excess events broadly distributed in disease categories not identified in previous studies as areas of concern.


CONCLUSIONS
At 1 year, bevacizumab and ranibizumab had equivalent effects on visual acuity when administered according to the same schedule. Ranibizumab given as needed with monthly evaluation had effects on vision that were equivalent to those of ranibizumab administered monthly. Differences in rates of serious adverse events require further study. (Funded by the National Eye Institute; ClinicalTrials.gov number, NCT00593450.).
Motivation as the Readiness to Act on Moral Commitments

A famous musician was walking through a park. A busker recognized him and immediately begged him to play. The musician initially refused, but a crowd began to grow and chant with the anticipation of witnessing a concert.
Recurrent World Models Facilitate Policy Evolution

A generative recurrent neural network is quickly trained in an unsupervised manner to model popular reinforcement learning environments through compressed spatiotemporal representations. The world model’s extracted features are fed into compact and simple policies trained by evolution, achieving state of the art results in various environments. We also train our agent entirely inside of an environment generated by its own internal world model, and transfer this policy back into the actual environment. Interactive version of paper: https://worldmodels.github.io
Towards a standardized method of developing quality indicators for palliative care: protocol of the Quality indicators for Palliative Care (Q-PAC) study

BACKGROUND
In recent years, there have been several studies, using a wide variety of methods, aimed at developing quality indicators for palliative care. In this Quality Indicators for Palliative Care study (Q-PAC study) we have applied a scientifically rigorous method to develop a comprehensive and valid quality indicator set which can contribute to a standardized method for use in other countries.


METHODS AND DESIGN
Firstly, an extensive literature review identified existing international quality indicators and relevant themes for measuring quality in palliative care. Secondly, the most relevant of these were selected by an expert panel. Thirdly, those prioritized by the experts were scored by a second multidisciplinary expert panel for usability and relevance, in keeping with the RAND/UCLA-method, combining evidence with consensus among stakeholders. This panel included carers and policymakers as well as patients and next-of-kin. Fourthly, the draft set was tested and evaluated in practice for usability and feasibility; the indicators were then translated into questionnaires presented to patients, next-of-kin and care providers. To encourage the acceptance and use of the indicators, stakeholders, including national palliative care organizations, were involved throughout the whole project.


CONCLUSION
Our indicator development trajectory resulted in a set of quality indicators applicable to all patients in all palliative care settings. The set includes patient and relative perspectives and includes outcome, process and structure indicators. Our method can contribute internationally to a more standardized and rigorous approach to developing quality indicators for palliative care.
Association of preoperative levels of selected blood inflammatory markers with prognosis in gliomas

BACKGROUND
Red cell distribution width (RDW), neutrophil-lymphocyte ratio (NLR), and platelet count (PLT) routinely tested as part of the complete blood count are indicative of systemic inflammation. The prognostic significance of NLR and PLT in cancer was demonstrated in many studies while the role of RDW has been hardly investigated. The present study aimed to assess the association of RDW, NLR, and PLT with survival and tumor grade in glioma patients.


METHODS
Clinical data from 178 patients with primary gliomas treated in a single institution were retrospectively analyzed. Receiver operating characteristic curves for cutoff value determination, Kaplan-Meier survival analysis, various bivariate tests, and univariate and multivariate Cox regression analyses were performed.


RESULTS
Patients with high RDW (≥13.95) and NLR (≥4) levels had worse overall survival (OS) (Wilcoxon test, P<0.026 and P<0.003, respectively) while the effect of thrombocytosis (≥400×109/L) on prognosis was not significant. Besides, a strong association between RDW and NLR was found (Spearman's rho =0.230, P<0.02; χ2=8.887, P<0.03; Mann-Whitney U-test, P<0.017). Moreover, RDW and NLR were significantly associated with tumor grade. In univariate Cox analysis, elevated NLR (hazard ratio, HR 1.385; confidence interval, CI 1.020-1.881, P<0.037), older age (HR 0.452, CI 0.329-0.621, P<0), and higher tumor grade (HR 1.624, CI 1.187-2.223, P<0.002) were associated with poor outcomes. In the multivariate analysis, tumor grade, age, and Karnofsky performance score were identified as being independently prognostic for OS.


CONCLUSION
Preoperative NLR and RDW values can help to evaluate disease progression and outcomes in patients with gliomas, thereby contributing to patient follow-up optimization.
Casinos, Crime, and Community Costs

We examine the relationship between casinos and crime using county-level data for the United States between 1977 and 1996. Casinos were nonexistent outside Nevada before 1978, and expanded to many other states during our sample period. Most factors that reduce crime occur before or shortly after a casino opens, whereas those that increase crime, including problem and pathological gambling, occur over time. The results suggest that the effect on crime is low shortly after a casino opens, and grows over time. Roughly 8 of crime in casino counties in 1996 was attributable to casinos, costing the average adult 75 per year.
System barriers to the evidence-based care of acute coronary syndrome patients in China: qualitative analysis.

BACKGROUND
Organizational and wider health system factors influence the implementation and success of interventions. Clinical Pathways in Acute Coronary Syndromes 2 is a cluster randomized trial of a clinical pathway-based intervention to improve acute coronary syndrome care in hospitals in China. We performed a qualitative evaluation to examine the system-level barriers to implementing clinical pathways in the dynamic healthcare environment of China.


METHODS AND RESULTS
A qualitative descriptive analysis of 40 in-depth interviews with health professionals conducted in a sample of 10 hospitals purposively selected to explore barriers to implementation of the intervention. Qualitative data were analyzed using the Framework method. In-depth interviews identified 5 key system-level barriers to effective implementation: (1) leadership support for implementing quality improvement, (2) variation in the capacity of clinical services and quality improvement resources, (3) fears of patient disputes and litigation, (4) healthcare funding constraints and high out-of-pocket expenses, and (5) patient-related factors.


CONCLUSIONS
System-level barriers affect the ability of acute coronary syndrome clinical pathways to change practice. Addressing these barriers in the context of current and planned national health system reform will be critical for future improvements in the management of acute coronary syndromes, and potentially other hospitalized conditions, in China. Clinical Trial Registration- URL: http://www.anzctr.org.au/default.aspx. Register. Unique identifier: ACTRN12609000491268.
Diffusion-weighted MRI in acute stroke within the first 6 hours: 1.5 or 3.0 Tesla?

OBJECTIVES
To compare the sensitivity and specificity of 1.5-T and 3.0-T diffusion-weighted MRI (DWI) to detect hyperacute ischemic stroke lesions.


METHODS
We blindly reviewed the DWI of 135 acute stroke patients and 34 controls performed at 1.5 T (n = 108) or 3.0 T (n = 61). The stroke patients all had subsequently proved carotid territory ischemic stroke and were imaged within the first 6 hours after stroke onset. Four readers (2 neuroradiologists and 2 stroke neurologists) blinded to clinical data and magnetic field strength recorded the presence of ischemic lesions on DWI and apparent diffusion coefficient (ADC) maps if necessary. Sensitivity, specificity, and false-negative rates were computed. Signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), and DWI contrasts were calculated at both field strengths.


RESULTS
The accuracy of DWI in stroke diagnosis was superior at 1.5 T (98.8%) than at 3.0 T (90.9%, p = 0.03). The sensitivity decreased from 99.1% at 1.5 T to 92.5% at 3.0 T (p = 0.06) and the specificity from 97.8% to 84.1% (p = 0.002). ADC map readings did not improve accuracy, sensitivity, or specificity. The false-negative rate was 0.6% at 1.5 T and 6.1% at 3.0 T. Type of readers, stroke severity, and type of the coil did not affect diagnosis value. SNR and CNR were significantly higher at 3 T (p < 0.0001) but DWI contrast was lower (p = 0.04).


CONCLUSIONS
Blind reading by 4 experts of a large series of images shows that 1.5-T diffusion-weighted MRI (DWI) is better than 3.0-T DWI for the imaging of hyperacute stroke during the therapeutic window of thrombolysis.
Terms of Trade and Global Efficiency Effects of Free Trade Agreements, 1990-2002

This paper infers the terms of trade effects of the Free Trade Agreements (FTAs) of the 1990s. Using panel data methods to resolve two way causality between trade and FTAs, we estimate large FTA effects on bilateral trade volume in 2 digit manufacturing goods from 1990-2002. We deduce the terms of trade changes implied by these volume effects for 40 countries plus a rest-of-the-world aggregate using the structural gravity model. Some countries gain over 10%, some lose less than 0.2%. Overall, using a novel measure of the change in iceberg melting, global efficiency rises 0.62%. JEL Classification Codes: F13, F14, F16