LLukas22/scidocs huggingface dataset:
Contribution of glucocerebrosidase mutation in a large cohort of sporadic Parkinson's disease in Taiwan.

BACKGROUND AND PURPOSE
The association between glucocerebrosidase (GBA) mutations and Parkinson's disease (PD) is attracting increased attention worldwide. In patients of Chinese ethnicity, other than the common L444P mutation, a few mutations have been reported. However, the contribution of GBA to PD can be answered only by a thorough investigation of its mutations in a unique large population.


METHODS
We enrolled 1747 participants: 967 PD patients and 780 healthy individuals. We screened entire GBA coding regions and exon-intron boundaries in 30 randomly chosen PD patients, followed by testing five variants (L444P, D409H, R120W, L174P, and Q497R) in all participants. The G2385R and R1628P in LRRK2 had been previously studied in almost all participants.


RESULTS
  In total, 36 patients (3.72%) carried a heterozygous mutant GBA allele (27 L444P, 7 RecNciI, and 2 D409H). Only two controls (0.26%) carried heterozygous GBA mutation (1 L444P and 1 RecNciI). In PD group, the mean age at onset in carriers was younger than in non-carriers. The difference in percentage of mutation frequencies between patients and controls was highly significant for the L444P mutation (P < 0.0001). One L444P carrier was also associated with LRRK2 G2385R variant, but no atypical Parkinsonism was observed.


CONCLUSIONS
The present study ascertains that L444P mutation in GBA gene may contribute to an earlier onset of development of PD in Han/Chinese population. Following LRRK2 variants, GBA is the second most frequent mutations indicated for sporadic PD development in the Han/Chinese population. These GBA carriers are associated with an earlier onset of Parkinsonism.
The Potent and Broadly Neutralizing Human Dengue Virus-Specific Monoclonal Antibody 1C19 Reveals a Unique Cross-Reactive Epitope on the bc Loop of Domain II of the Envelope Protein

UNLABELLED
Following natural dengue virus (DENV) infection, humans produce some antibodies that recognize only the serotype of infection (type specific) and others that cross-react with all four serotypes (cross-reactive). Recent studies with human antibodies indicate that type-specific antibodies at high concentrations are often strongly neutralizing in vitro and protective in animal models. In general, cross-reactive antibodies are poorly neutralizing and can enhance the ability of DENV to infect Fc receptor-bearing cells under some conditions. Type-specific antibodies at low concentrations also may enhance infection. There is an urgent need to determine whether there are conserved antigenic sites that can be recognized by cross-reactive potently neutralizing antibodies. Here, we describe the isolation of a large panel of naturally occurring human monoclonal antibodies (MAbs) directed to the DENV domain II fusion loop (FL) envelope protein region from subjects following vaccination or natural infection. Most of the FL-specific antibodies exhibited a conventional phenotype, characterized by low-potency neutralizing function and antibody-dependent enhancing activity. One clone, however, recognized the bc loop of domain II adjacent to the FL and exhibited a unique phenotype of ultrahigh potency, neutralizing all four serotypes better than any other previously described MAb recognizing this region. This antibody not only neutralized DENV effectively but also competed for binding against the more prevalent poor-quality antibodies whose binding was focused on the FL. The 1C19 human antibody could be a promising component of a preventative or therapeutic intervention. Furthermore, the unique epitope revealed by 1C19 suggests a focus for rational vaccine design based on novel immunogens presenting cross-reactive neutralizing determinants.


IMPORTANCE
With no effective vaccine available, the incidence of dengue virus (DENV) infections worldwide continues to rise, with more than 390 million infections estimated to occur each year. Due to the unique roles that antibodies are postulated to play in the pathogenesis of DENV infection and disease, there is consensus that a successful DENV vaccine must protect against all four serotypes. If conserved epitopes recognized by naturally occurring potently cross-neutralizing human antibodies could be identified, monovalent subunit vaccine preparations might be developed. We characterized 30 DENV cross-neutralizing human monoclonal antibodies (MAbs) and identified one (1C19) that recognized a novel conserved site, known as the bc loop. This antibody has several desirable features, as it neutralizes DENV effectively and competes for binding against the more common low-potency fusion loop (FL) antibodies, which are believed to contribute to antibody-mediated disease. To our knowledge, this is the first description of a potent serotype cross-neutralizing human antibody to DENV.
The effect of continuous versus intermittent renal replacement therapy on the outcome of critically ill patients with acute renal failure (CONVINT): a prospective randomized controlled trial

INTRODUCTION
Acute renal failure (ARF) requiring renal replacement therapy (RRT) occurs frequently in ICU patients and significantly affects mortality rates. Previously, few large clinical trials investigated the impact of RRT modalities on patient outcomes. Here we investigated the effect of two major RRT strategies (intermittent hemodialysis (IHD) and continuous veno-venous hemofiltration (CVVH)) on mortality and renal-related outcome measures.


METHODS
This single-center prospective randomized controlled trial ("CONVINT") included 252 critically ill patients (159 male; mean age, 61.5 ± 13.9 years; Acute Physiology and Chronic Health Evaluation (APACHE) II score, 28.6 ± 8.8) with dialysis-dependent ARF treated in the ICUs of a tertiary care academic center. Patients were randomized to receive either daily IHD or CVVH. The primary outcome measure was survival at 14 days after the end of RRT. Secondary outcome measures included 30-day-, intensive care unit-, and intrahospital mortality, as well as course of disease severity/biomarkers and need for organ-support therapy.


RESULTS
At baseline, no differences in disease severity, distributions of age and gender, or suspected reasons for acute renal failure were observed. Survival rates at 14 days after RRT were 39.5% (IHD) versus 43.9% (CVVH) (odds ratio (OR), 0.84; 95% confidence interval (CI), 0.49 to 1.41; P = 0.50). 14-day-, 30-day, and all-cause intrahospital mortality rates were not different between the two groups (all P > 0.5). No differences were observed in days on RRT, vasopressor days, days on ventilator, or ICU-/intrahospital length of stay.


CONCLUSIONS
In a monocentric RCT, we observed no statistically significant differences between the investigated treatment modalities regarding mortality, renal-related outcome measures, or survival at 14 days after RRT. Our findings add to mounting data demonstrating that intermittent and continuous RRTs may be considered equivalent approaches for critically ill patients with dialysis-dependent acute renal failure.


TRIAL REGISTRATION
NCT01228123, clinicaltrials.gov.
The 52-Week High and Momentum Investing

When coupled with a stock’s current price, a readily available piece of information— the 52-week high price—explains a large portion of the profits from momentum investing. Nearness to the 52-week high dominates and improves upon the forecasting power of past returns (both individual and industry returns) for future returns. Future returns forecast using the 52-week high do not reverse in the long run. These results indicate that short-term momentum and long-term reversals are largely separate phenomena, which presents a challenge to current theory that models these aspects of security returns as integrated components of the market’s response to news. There is substantial evidence that stock prices do not follow random walks and that returns are predictable. Jegadeesh and Titman (1993) show that stock returns exhibit momentum behavior at intermediate horizons. A self-financing strategy that buys the top 10% and sells the bottom 10% of stocks ranked by returns during the past 6 months, and holds the positions for 6 months, produces profits of 1% per month. Moskowitz and Grinblatt (1999) argue that momentum in individual stock returns is driven by momentum in industry returns. DeBondt and Thaler (1985), Lee and Swaminathan (2000), and Jegadeesh and Titman (2001) document long-term reversals in stock returns. Stocks that perform poorly in the past perform better over the next 3 to 5 years than stocks that perform well in the past. Barberis, Shleifer and Vishny (1998), Daniel, Hirshleifer, and Subrahmanyam (1998), and Hong and Stein (1999) present theoretical models that attempt to explain the coexistence of intermediate horizon momentum and long horizon reversals in individual stock returns as the result of systematic violations of rational behavior by traders. In Barberis, Shleifer, and Vishny and in Hong and Stein, momentum occurs because traders are slow to revise their priors when new information arrives. Longterm reversals occur because when traders finally do adjust, they overreact. In Daniel, Hirshleifer, and Subrahmanyam, momentum occurs because traders overreact to prior information when new information confirms it. Long-term reversals occur as the overreaction is corrected in the long run. In all three models, short-term momentum and long-term reversals are sequential components of the process by which the market absorbs news. In this paper, we find that a readily available piece of information – the 52week high price – largely explains the profits from momentum investing. We examine the 52-week high because the models predict, in particular, that traders are slow to react, or overreact, to good news. A stock whose price is at or near its 52week high is a stock for which good news has recently arrived. This may be the time when biases in how traders react to news, and hence profits to momentum investing, are at their peaks. Indeed, we find that profits to a momentum strategy based on nearness to the 52-week high are superior to those where the arrival of news is measured by a return computed over a fixed-length interval in the past (e.g., 6 months).
Optical properties of PbTiO3 films deposited by sol-gel process and pulsed laser deposition: a comparison

Lead titanate PbTiO3(PT) thin films were prepared on single-crystal MgO(100) substrates by sol-gel process (SG) and pulsed laser deposition (PLD) techniques. The SG coating solutions were synthesized from lead (II) acetate, titanium isopropoxide precursors using acetic acid and diethanolamine (DEA). The SG films were spin coated at 2000 rpm, dried in air at 350 degree(s)C and rapid thermally annealed at between 400-650 degree(s)C temperature range. PLD films were grown at 2x10-6 Torr chamber pressure in flowing oxygen and at the substrate temperature of 600 degree(s)C. The films were characterized by x-ray diffraction (XRD), scanning electron microscopy (SEM), and scanning spectrophotometry. The optical properties of the PT films were evaluated from spectral transmittance and reflectance measurements. Optical and structural properties of SG and PLD thin films grown at 600 degree(s)C substrate temperature were compared. XRD analysis indicates that PLD films grow strongly textured on MgO(100) substrate. In contrast, SG films were randomly oriented. SEM showed that the surface of the SG PT films heat treated at above 600 degree(s)C had smaller grains. In contrast PLD grown films had a well-developed dense and uniform grain structure with larger grain size. The optical constants such as refractive index (n), extinction coefficient (k) and optical band gap (Eg) values were found to depend on the preparation techniques. The optical band gap values are in the range of 2.98-3.24 eV depending on the deposition method.© (2001) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
R Peak Detection in Electrocardiogram Signal Based on an Optimal Combination of Wavelet Transform, Hilbert Transform, and Adaptive Thresholding

Electrocardiogram (ECG) is one of the most common biological signals which play a significant role in the diagnosis of heart diseases. One of the most important parts of ECG signal processing is interpretation of QRS complex and obtaining its characteristics. R wave is one of the most important sections of this complex, which has an essential role in diagnosis of heart rhythm irregularities and also in determining heart rate variability (HRV). This paper employs Hilbert and wavelet transforms as well as adaptive thresholding method to investigate an optimal combination of these signal processing techniques for the detection of R peak. In the experimental sections of this paper, the proposed algorithms are evaluated using both ECG signals from MIT-BIH database and synthetic data simulated in MATLAB environment with different arrhythmias, artifacts, and noise levels. Finally, by using wavelet and Hilbert transforms as well as by employing adaptive thresholding technique, an optimal combinational method for R peak detection namely WHAT is obtained that outperforms other techniques quantitatively and qualitatively.
Technology Adoption among Small and Medium Enterprises ( SME ' s ) : A Research Agenda

This paper presents the research agenda that has been proposed to develop an integrated model to explain technology adoption of SMEs in Malaysia. SMEs form over 90% of all business entities in Malaysia and they have been contributing to the development of the nation. Technology adoption has been a thorn issue among SMEs as they require big outlay which might not be available to the SMEs. Although resource has been an issue among SMEs they cannot lie low and ignore the technological advancements that are taking place at a rapid pace. With that in mind this paper proposes a model to explain the technology adoption issue among SMEs. Keywords-Technology adoption, integrated model, Small and Medium Enterprises (SME), Malaysia
Stochastic mobility-based path planning in uncertain environments

The ability of mobile robots to generate feasible trajectories online is an important requirement for their autonomous operation in unstructured environments. Many path generation techniques focus on generation of time- or distance-optimal paths while obeying dynamic constraints, and often assume precise knowledge of robot and/or environmental (i.e. terrain) properties. In uneven terrain, it is essential that the robot mobility over the terrain be explicitly considered in the planning process. Further, since significant uncertainty is often associated with robot and/or terrain parameter knowledge, this should also be accounted for in a path generation algorithm. Here, extensions to the rapidly exploring random tree (RRT) algorithm are presented that explicitly consider robot mobility and robot parameter uncertainty based on the stochastic response surface method (SRSM). Simulation results suggest that the proposed approach can be used for generating safe paths on uncertain, uneven terrain.
Three-dimensional fusion of coronary arteries with myocardial perfusion distributions: clinical validation.

UNLABELLED
Clinical decisions regarding diagnosis and effective treatment of coronary artery disease frequently require integration of information from various imaging modalities, which are acquired, processed, and read at different physical locations and times. We have developed methods to integrate the information in 2 cardiac imaging studies, perfusion SPECT and coronary angiography. Three-dimensional (3D) models of the coronary artery tree created from biplane angiograms were automatically aligned with 3D models of the left ventricular epicardial surface created from perfusion SPECT. Myocardial mass at risk was used as a unique measure to validate the accuracy of the unification.


METHODS
Thirty patients were injected with the perfusion agent (99m)Tc-tetrosfosmin during balloon occlusion while undergoing percutaneous transluminal coronary angioplasty for single-vessel coronary artery disease. Thus, a single, severe perfusion defect was induced by a single coronary artery occlusion of known severity and placement. The accuracy of the unification was measured by computing the overlap between physiologic area at risk, determined using SPECT perfusion quantification techniques only, and anatomic area at risk, determined using coronary artery anatomy aligned with the epicardial surface of the left ventricle.


RESULTS
The unification resulted in an 80% overlap of areas at risk, and an overlap of 84% of normal areas, for all coronary artery distributions. The mass at risk measured based on the unified anatomic information correlated with the physiologically based mass at risk as y = 0.92x + 10.3 g; r = 0.76, SEE = 10.4 g.


CONCLUSION
A unification algorithm for automatically registering 3D models of the epicardial surface from perfusion SPECT and 3D coronary artery trees from coronary angiography has been presented and validated in 30 patient studies.
Patient-experienced effect of an active implementation of a disease management programme for COPD – a randomised trial

BACKGROUND
People living with chronic disease currently account for the majority of the total healthcare costs. The Central Denmark Region implemented a disease management programme (DMP) for chronic obstructive pulmonary disease (COPD) in 2008. This presented an opportunity to examine the effect of an evidence-based, planned and proactive implementation of a DMP compared to the usual implementation strategy.


METHODS
We performed a block- and cluster-randomised controlled trial with two groups and an extra external control group. The primary outcome was patients' assessment of their care after using an active implementation model for a DMP for COPD measured with the Patient-Assessment-of-Chronic-Illness-Care (PACIC) instrument. At baseline, questionnaires were sent to 2,895 patients identified by an algorithm based on health registry data on lung-related contacts to the healthcare system. Patients were asked to confirm or refute their diagnosis of COPD. Of those who responded, 1,445 (72.8%) confirmed their diagnosis. PACIC data were collected at baseline and at a 12-month follow-up for 744 (51.1%) patients.


RESULTS
Comparing the three groups after the implementation of the DMP, we found a statistically significantly higher change in the PACIC score in the intervention group than in the control groups. No statistically significant differences were found between the control and the external control groups in any of the dimensions.


CONCLUSIONS
Reinforcing the role of general practice as coordinator for care-and self-management-support with an active implementation of a DMP for COPD made patients score higher on the PACIC instrument, which indicates a better experience of the received healthcare.


TRIAL REGISTRATION
NCT01228708.
A generic RTOS model for real-time systems simulation with systemC

The main difficulties in designing real-time systems are related to time constraints: if an action is performed too late, it is considered as a fault (with different levels of criticism). Designers need to use a solution that fully supports timing constraints and enables them to simulate early on the design process a real-time system. One of the main difficulties in designing HW/SW systems resides in studying the effect of serializing tasks on processors running a Real-Time Operating System (RTOS). In this paper, we present a generic model of RTOS based onSystemC. It allows assessing real-time performances and the influence of scheduling according to RTOS properties such as scheduling policy, context-switch time and scheduling latency.
Final results of the Balloon vs Optimal Atherectomy Trial (BOAT)

BACKGROUND
Previous directional coronary atherectomy (DCA) trials have shown no significant reduction in angiographic restenosis, more in-hospital complications, and higher 1-year mortality than conventional balloon angioplasty (percutaneous transluminal coronary angioplasty [PTCA]). DCA, however, has subsequently evolved toward a more "optimal" technique (larger devices, more extensive tissue removal, and routine postdilation to obtain diameter stenosis <20%).


METHODS AND RESULTS
The Balloon vs Optimal Atherectomy Trial (BOAT) was conducted to evaluate whether optimal DCA provides short- and long-term benefits compared with balloon angioplasty. One thousand patients with single de novo, native vessel lesions were randomized to either DCA or PTCA at 37 participating centers. Lesion success was obtained in 99% versus 97% (P=.02) of patients to a final residual diameter stenosis of 15% versus 28% (P<.0001) for DCA and PTCA, respectively, the latter including stents in 9.3% of the patients. There was no increase in major complications (death, Q-wave myocardial infarction, or emergent coronary artery bypass graft surgery [2.8% versus 3.3%]), although creatine kinase-MB >3X normal was more common with DCA (16% versus 6%; P<.0001). Angiographic restudy (in 79.6% of eligible patients at 7.2+/-2.6 [median, 6.9] months) showed a significant reduction in the prespecified primary end point of angiographic restenosis by DCA (31.4% versus 39.8%; P=.016). Clinical follow-up to 1 year showed nonsignificant 13% to 17% reductions in the DCA arm of the study for mortality rate (0.6% versus 1.6%; P=.14), target-vessel revascularization (17.1% versus 19.7%; P=.33), target-site revascularization (15.3% versus 18.3%; P=.23), and target-vessel failure (death, Q-wave myocardial infarction, or target-vessel revascularization, 21.1% versus 24.8%; P=.17).


CONCLUSIONS
Optimal DCA provides significantly higher short-term success, lower residual stenosis, and lower angiographic restenosis than conventional PTCA, despite failing to reach statistical significance for reducing late clinical events compared with PTCA with stent backup.
Bronfenbrenner's Ecological Systems Theory

This theory looks at a child’s development within the context of the system of relationships that form his or her environment. Bronfenbrenner’s theory defines complex “layers” of environment, each having an effect on a child’s development. This theory has recently been renamed “bioecological systems theory” to emphasize that a child’s own biology is a primary environment fueling her development. The interaction between factors in the child’s maturing biology, his immediate family/community environment, and the societal landscape fuels and steers his development. Changes or conflict in any one layer will ripple throughout other layers. To study a child’s development then, we must look not only at the child and her immediate environment, but also at the interaction of the larger environment as well.
Is “ Backshoring ” a New Fad or a Viable Business Option ?

Recently, the news about companies bringing back their formerly offshored products and processes has increased. There are indicators that after 50 years of extensive offshoring, companies are rethinking their strategies and realizing the advantages of onshore production and services. For some companies, offshoring might continue as an appropriate strategy, while for others the disadvantages dominate as offshore locations lengthen their delivery times, increase capital tied up in safety stock, and open up the company to uncontrollable quality issues. Another strengthening factor for the backshoring trend is that the conditions of low-cost and industrialized countries have changed as well. Lately, the former ones have faced increasing wage rates and labor shortages, while the latter ones have been able to employ new technologies to increase their productivity (Imberman, 2013; Tate, 2014; Tate, Ellram, Schoenherr and Petersen, 2014a).