LLukas22/scidocs huggingface dataset:
Cluster randomized controlled trial of a patient and general practitioner intervention to improve the management of multiple risk factors after stroke: stop stroke.

BACKGROUND AND PURPOSE
Stroke is a major public health concern worldwide and survivors remain at high risk of recurrence. Secondary prevention requires management of multiple risk factors but current management is suboptimal. Evidence of the effectiveness of interventions to improve poststroke risk factor management from well-designed trials is limited. We assessed the effectiveness of a patient and general practitioner systematic follow-up intervention to improve risk factor management after stroke.


METHODS
We undertook a pragmatic cluster trial involving 523 consecutive incident stroke survivors identified using the population South London Stroke Register and registered with general practices in inner-city London. Practices were randomized to receive the intervention or usual care. The intervention entailed systematically identifying stroke survivors' risk factors for recurrence and providing tailored evidence-based management advice to general practitioners, patients, and caregivers at 10 weeks, 5 months, and 8 months poststroke. The primary outcome was management of key modifiable risk factors for stroke at 1 year with 3 end points: treatment with antihypertensive therapy, treatment with antiplatelet therapy, and smoking cessation. Hierarchical testing was used to adjust for multiple endpoints. Analysis was by intention to treat. This study is registered as number ISRCTN10730637.


RESULTS
The absolute risk reduction (and 95% CI) for each outcome was -3.7% (-13.0% to 5.6%) for treatment with antihypertensives; -2.3% (-12.0% to 7.6%) for treatment with antiplatelets; and -0.6% (-14.5% to 13.5%) for smoking cessation. Treatment effects were confirmed in the generalized linear model adjusting for clustering and predefined confounders.


CONCLUSIONS
No improvement in risk factor management was demonstrated as a result of this patient, caregiver, and healthcare professional systematic follow-up system. Further evidence of how to effectively alter behavior of patients/caregivers and professionals is required if tailored information on risk and its treatment is to be of any clinical benefit.
LATENT SPACE MODELS FOR MULTIVIEW NETWORK DATA.

Social relationships consist of interactions along multiple dimensions. In social networks, this means that individuals form multiple types of relationships with the same person (e.g., an individual will not trust all of his/her acquaintances). Statistical models for these data require understanding two related types of dependence structure: (i) structure within each relationship type, or network view, and (ii) the association between views. In this paper, we propose a statistical framework that parsimoniously represents dependence between relationship types while also maintaining enough flexibility to allow individuals to serve different roles in different relationship types. Our approach builds on work on latent space models for networks [see, e.g., J. Amer. Statist. Assoc.97 (2002) 1090-1098]. These models represent the propensity for two individuals to form edges as conditionally independent given the distance between the individuals in an unobserved social space. Our work departs from previous work in this area by representing dependence structure between network views through a multivariate Bernoulli likelihood, providing a representation of between-view association. This approach infers correlations between views not explained by the latent space model. Using our method, we explore 6 multiview network structures across 75 villages in rural southern Karnataka, India [Banerjee et al. (2013)].
Axions and Their Relatives

A review of the status of axions and axion-like particles is given. Special attention is devoted to the recent results of the PVLAS collaboration, which are in conflict with the CAST data and with the astrophysical constraints. Solutions to the puzzle and the implications for new physics are discussed. The question of axion-like particles being dark matter is also addressed.
Introduction: attachment theory and psychotherapy.

In this introduction to the JCLP: In Session 69(11) issue on attachment theory and psychotherapy, the key points of attachment theory (Bowlby, , , 1981) and its relevance to psychotherapy are briefly described. The aim of this issue is to provide case illustrations of how an attachment theory perspective and principles can expand our understanding of psychotherapy practice.
Simulated worlds: rapid generation of web-based role-play

This paper describes and discusses the pedagogical foundations and the technical features that enables rapid generation of role-play simulations on the Web. The pedagogical approach of this learning technology is based on the principles of dynamic goal-based learning, and learning by doing within the context of authentic educational settings where students are allowed the opportunity to acquire the intended learning outcomes by making mistakes in safe environments. Based on this clearly articulated and proven pedagogical design, we are able to develop a process by which a designer can quickly create a web-based role-play simulation. Incremental modification is an essential feature in this rapid cyclic development process allowing further refinement to the simulation as it progresses. The technology used to support this environment is FablusiTM Role-Play Simulation Generator (see Fablusi Website at http://www.Fablusi.com/authoring/).
Five-Month Observation of Persistent Diabetic Macular Edema after Intravitreal Injection of Ozurdex Implant

AIMS
This retrospective analysis was aimed at evaluating the effectiveness of treatment of persistent diabetic macular edema with intravitreal injections of 0.7 mg dexamethasone implant Ozurdex. The study comprised three male patients (6 eyes).


RESULTS
The average thickness of the retina at baseline was 632  μm, the medial BCVA was 0.8 logMAR, and corrected intraocular pressure was 13.7 mmHg. The maximum decrease in mean retinal thickness was observed at four weeks following the treatment and was 365  μm (-267  μm) and visual acuity improved by an average of two lines and was 0.6 logMAR. The largest increase in mean retinal thickness to average of 528  μm (+164  μm) occurred at 16 weeks and the average BCVA was 0.614 lines BCVA logMAR. In one eye, there was a steroid cataract development after the third dose of dexamethasone implant of 0.7 mg.


CONCLUSIONS
The intravitreal dexamethasone implant treatment of patients with persistent diabetic macular edema in whom laser photocoagulation proved to be ineffective and as a result they required a monthly injection of anti-VEGF factors (Ranibizumab, Bevacizumab) may be a good alternative to extending the interval of injections. However, reinjections involve a high risk of developing poststeroid cataracts, which is not without significance in middle-aged patients.
Defining nicotine dependence for genetic research: evidence from Australian twins.

BACKGROUND
Whether current criteria used to define nicotine dependence are informative for genetic research is an important empirical question. The authors used items of the DSM-IV and of the Heaviness of Smoking Index to characterize the nicotine dependence phenotype and to identify salient symptoms in a genetically informative community sample of Australian young adult female and male twins.


METHOD
Phenotypic and genetic factor analyses were performed on nine dependence symptoms (the seven DSM-IV substance dependence criteria and the two Heaviness of Smoking Index (HSI) items derived from the Fagerström Tolerance Questionnaire, time to first cigarette in the morning and number of cigarettes smoked per day). Phenotypic and genetic analyses were restricted to ever smokers.


RESULTS
Phenotypic nicotine dependence symptom covariation was best captured by two factors with a similar pattern of factor loadings for women and men. In genetic factor analysis item covariation was best captured by two genetic but one shared environmental factor for both women and men; however, item factor loadings differed by gender. All nicotine dependence symptoms were substantially heritable, except for the DSM-IV criterion of 'giving up or reducing important activities in order to smoke', which was weakly familial.


CONCLUSIONS
The salient behavioral indices of nicotine dependence are similar for women and men. DSM-IV criteria of tolerance, withdrawal, and experiencing difficulty quitting and HSI items time to first cigarette in the morning and number of cigarettes smoked per day may represent the most highly heritable symptoms of nicotine dependence for both women and men.
RIGOROUS PHOTOGRAMMETRIC PROCESSING OF HIGH RESOLUTION SATELLITE IMAGERY

This paper deals with investigations on the geometric reconstruction and sensor calibration of satellite–based optical imaging systems using linear arrays in pushbroom mode, like SPOT, IRS–1C and MOMS–2P/PRIRODA. The geometric model of the sensor is based on an extension of a SPOT model developed by V. Kratky. This geometric solution combines the principle of rigorous photogrammetric bundle formulation with additional constraints derived from known relations assuming an elliptic orbit. The attitude parameters are modelled by a simple polynomial model being linear or quadratic. Ephemeris data (orbital position and attitude data) are not necessary but are optional. The parameters of the interior orientation, e.g. focal length and principle point coordinates, are determined by self–calibration. The sensor model can be easily extended to process images from other high resolution imaging systems as they become available. The flexibility and very good accuracy of the solution will be demonstrated with MOMS–2P/PRIRODA imagery, since multiple scenes with overlapping images are available with a relatively high image resolution.
Smartphone Addiction Inventory (SPAI): Psychometric properties and confirmatory factor analysis

The Smartphone Addiction Inventory (SPAI) was developed to assess smartphone addiction in Taiwanese university students. The purpose of the current research is to evaluate the factor structure and psychometric properties of the SPAI in Italian university students. A total of 485 university students (29.3% boys) completed the SPAI and the Young’s Internet Addiction Test (IAT). The proposed four-factor model of the SPAI-I was tested by computing CFA, and the results of the goodness of fit indices indicated an ambiguous solution. An exploratory-confirmatory cross validation strategy was applied for a better trimming of SPAI-I factorial structure. Results suggested a five-factor solution that explained 53% of the total variance (Time Spent, Compulsivity, Daily Life Interference, Craving, and Sleep Interference). Excellent internal consistency and five factor correlations were reported for the SPAI-I. This five-factor model showed good convergent validity with the Internet Addiction Disorder Test. Considering that evidence shows that overuse of a smartphone can be associated with adverse and problematic effects, the SPAI-I should be useful for determining its potential for the use in future research in Europe and for comparing the evaluation of smartphone overuse of young European people with other international Asiatic studies that have incorporated the SPAI. © 2016 Elsevier Ltd. All rights reserved.
Densest Subgraph in Dynamic Graph Streams

In this paper, we consider the problem of approximating the densest subgraph in the dynamic graph stream model. In this model of computation, the input graph is defined by an arbitrary sequence of edge insertions and deletions and the goal is to analyze properties of the resulting graph given memory that is sub-linear in the size of the stream. We present a single-pass algorithm that returns a (1 + ) approximation of the maximum density with high probability; the algorithm uses O( −2npolylog n) space, processes each stream update in polylog(n) time, and uses poly(n) post-processing time where n is the number of nodes. The space used by our algorithm matches the lower bound of Bahmani et al. (PVLDB 2012) up to a poly-logarithmic factor for constant . The best existing results for this problem were established recently by Bhattacharya et al. (STOC 2015). They presented a (2 + ) approximation algorithm using similar space and another algorithm that both processed each update and maintained a (4 + ) approximation of the current maximum density in polylog(n) time per-update.
Improving SCTP Performance by Jitter-Based Congestion Control over Wired-Wireless Networks

With the advances of wireless communication technologies, wireless networks gradually become themost adopted communication networks in the new generation Internet. Computing devices and mobile devices may be equipped with multiple wired and/or wireless network interfaces. Stream Control Transmission Protocol (SCTP) has been proposed for reliable data transport and its multihoming feature makes use of network interfaces effectively to improve performance and reliability. However, like TCP, SCTP suffers unnecessary performance degradation over wired-wireless heterogeneous networks. The main reason is that the original congestion control scheme of SCTP cannot differentiate loss events so that SCTP reduces the congestion window inappropriately. In order to solve this problem and improve performance, we propose a jitter-based congestion control scheme with end-to-end semantics over wired-wireless networks. Besides, we solved ineffective jitter ratio problem which may cause original jitter-based congestion control scheme to misjudge congestion loss as wireless loss. Available bandwidth estimation scheme will be integrated into our congestion control mechanism to make the bottleneck more stabilized. Simulation experiments reveal that our scheme (JSCTP) gives prominence to improve performance effectively over wired-wireless networks.
Hemodynamic Predictors of Heart Failure Morbidity and Mortality: Fluid or Flow?

BACKGROUND
Patients with advanced heart failure may continue for prolonged times with persistent hemodynamic abnormalities; intermediate- and long-term outcomes of these patients are unknown.


METHODS AND RESULTS
We used ESCAPE (Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness) trial data to examine characteristics and outcomes of patients with invasive hemodynamic monitoring during an acute heart failure hospitalization. Patients were stratified by final measurement of cardiac index (CI; L/min/m2) and pulmonary capillary wedge pressure (PCWP; mmHg) before catheter removal. The study groups were CI ≥ 2/PCWP < 20 (n = 74), CI ≥ 2/PCWP ≥ 20 (n = 37), CI < 2/PCWP < 20 (n = 23), and CI < 2/PCWP ≥ 20 (n = 17). Final CI was not associated with the combined risk of death, cardiovascular hospitalization, and transplantation (hazard ratio [HR]1.03, 95% confidence interval 0.96-1.11 per 0.2 L/min/m2 decrease, P = .39), but final PCWP ≥ 20 mmHg was associated with increased risk of these events (HR 2.03, 95% confidence interval 1.31-3.15, P < .01), as was higher final right atrial pressure (HR 1.09, 95% confidence interval 1.06-1.12 per mmHg increase, P < .01).


CONCLUSION
Final PCWP and final right atrial pressure were stronger predictors of postdischarge outcomes than CI in patients with advanced heart failure. The ability to lower filling pressures appears to be more prognostically important than improving CI in the management of patients with advanced heart failure. ClinicalTrials.govIdentifier: NCT00000619.
American voter to economic voter: Evolution of an idea

Abstract That The American Voter has had, and continues to have, a profound influence on the study of political behavior goes without saying. However, that influence has not touched all its subfields. Oddly, it has had next to no impact in investigations of economic voting. This peculiarity is striking, because the book has an extensive chapter on the topic, Chapter 14 entitled “The Economic Antecedents of Political Behavior.” Furthermore, in Chapter 14, the major theories and findings known today are laid out. Here we document this fact, then trace the “loss” of this potentially seminal essay. We conclude with a plausible explanation for this loss, and suggest a new direction economic voting research might take, based on revived attention to this neglected contribution.
Body Weight and Plasma Levels of Ghrelin and Leptin during Treatment with Olanzapine

Although enhanced appetite and weight gain are potential side effects of treatment with antipsychotic agents, particularly olanzapine and clozapine, the mechanisms underlying these side effects are poorly understood. Leptin and ghrelin were recently identified as hormones that play crucial roles in the regulation of energy balance and glucose metabolism. To elucidate relationships between weight change and plasma levels of ghrelin and leptin, we investigated the circulating ghrelin and leptin levels and body weight during olanzapine treatment. Twenty-four patients with schizophrenia were examined during 6-month administration of olanzapine. Ghrelin, leptin, weight and body mass index (BMI) were measured before and after 2, 4, 8, 12, 16, and 24 weeks of olanzapine treatment. The concentration of glucose and various lipid metabolic parameters were measured at baseline and at 24 weeks. Significant increases in weight, BMI and leptin were observed at week 24. On the other hand, the serum levels of ghrelin decreased significantly after olanzapine treatment. In addition, the level of ghrelin was negatively correlated with the leptin level, BMI and weight. The leptin level was positively correlated with both BMI and weight. Ghrelin is associated with metabolic changes, in combination with leptin, during olanzapine treatment. However, further large-scale and longitudinal studies are warranted to elucidate the metabolic changes involving ghrelin, leptin and insulin during treatment with antipsychotics.
Chronic Cellular Imaging of Mouse Visual Cortex During Operant Behavior and Passive Viewing

Nearby neurons in mammalian neocortex demonstrate a great diversity of cell types and connectivity patterns. The importance of this diversity for computation is not understood. While extracellular recording studies in visual cortex have provided a particularly rich description of behavioral modulation of neural activity, new methods are needed to dissect the contribution of specific circuit elements in guiding visual perception. Here, we describe a method for three-dimensional cellular imaging of neural activity in the awake mouse visual cortex during active discrimination and passive viewing of visual stimuli. Head-fixed mice demonstrated robust discrimination for many hundred trials per day after initial task acquisition. To record from multiple neurons during operant behavior with single-trial resolution and minimal artifacts, we built a sensitive microscope for two-photon calcium imaging, capable of rapid tracking of neurons in three dimensions. We demonstrate stable recordings of cellular calcium activity during discrimination behavior across hours, days, and weeks, using both synthetic and genetically encoded calcium indicators. When combined with molecular and genetic technologies in mice (e.g., cell-type specific transgenic labeling), this approach allows the identification of neuronal classes in vivo. Physiological measurements from distinct classes of neighboring neurons will enrich our understanding of the coordinated roles of diverse elements of cortical microcircuits in guiding sensory perception and perceptual learning. Further, our method provides a high-throughput, chronic in vivo assay of behavioral influences on cellular activity that is applicable to a wide range of mouse models of neurologic disease.
Correlations between two plaque indices in assessment of toothbrush effectiveness.

BACKGROUND
The Rustogi et al. Modified Navy (RMNPI) and Turesky et al Modification of the Quigley Hein (TQHPI) plaque indices are commonly used to measure plaque removal. This study evaluated the possible correlations of both indices using data relative to a single use assessment of plaque removal using commercially available toothbrushes.


METHODS
Single use crossover study designs have been previously reported. Disclosed plaque was scored pre- and post-brushing using both the RMNPI and the TQHPI. Sixty subjects, with an initial mean RMNPI score of 0.6 or greater, were enrolled and completed the study. No minimum score was required for TQHPI. After the initial scoring, the order for each index was randomized so that each subject was scored with either RMNPI followed by TQHPI or vice versa. Two manual toothbrushes [Oral-B CrossAction (CA) and Colgate Navigator (NA)] and one battery-powered brush (Crest SpinBrush Pro) (SBP) were evaluated in the trial. One examiner performed all clinical measurements. Pearson correlations were performed on whole mouth, buccal, and lingual plaque scores for the CA toothbrush.


RESULTS
Strong positive correlations were found between the two plaque indices for pre- and post-brushing scores for the whole mouth and on lingual and buccal surfaces, where Pearson correlation coefficients ranged between 0.963 and 0.995. There was no correlation between the pre-brushing plaque score and the amount of plaque removed by brushing indicating that higher plaque levels before brushing do not necessarily predict that greater amounts of plaque will be removed during toothbrushing. Each toothbrush was found to be safe and significantly reduced plaque levels after a single brushing (t-test, p=0.0001). Significantly greater plaque reductions were found with the CA than the NA and SBP toothbrushes at whole mouth, lingual, and approximal surfaces for both indices (analysis of variance (ANOVA), p < or = 0.0002 for all comparisons).


CONCLUSIONS
Strong positive correlations were found between two plaque indices (the RMNPI and TQHPI) for pre- and post-brushing scores at whole mouth, lingual, and buccal surfaces as assessed using data from a single use assessment of plaque removal. Efficacy data from this study demonstrated the CA toothbrush provided superior cleaning when compared to the NA manual toothbrush and SBP battery toothbrush.


CLINICAL IMPLICATIONS
Two commonly used indices for assessing plaque removal in clinical studies are RMNPI and TQHPI. However, each index differs in the way plaque is scored. This study used both indices to assess comparative toothbrush efficacy and showed a strong correlation between indices for both pre- and post- brushing plaque scores. The result suggests that both indices demonstrate sufficient sensitivity to differentiate toothbrush efficacy.