LLukas22/scidocs huggingface dataset:
The impact of Web quality and playfulness on user acceptance of online retailing

We investigated the effect of playfulness on user acceptance of online retailing and tested the relationship between Web quality factors and user acceptance behavior. A survey of 942 users of Web-based online retailing was conducted to test our model. The results showed that playfulness plays an important role in enhancing user attitude and behavioral intention to use a site. We also found that Web quality, categorized into system, information, and service quality, had a significant impact on the perceived ease of use, playfulness, and usefulness, and consequently, that it encouraged website use in the context of online retailing. Our study thus provided a balanced and integrative framework for determining Web quality. It enhanced our knowledge of the effect of playfulness, which should help Web practitioners and researchers better understand user behavior in Web-based online retailing. # 2007 Elsevier B.V. All rights reserved.
Clinical validity of a negative computed tomography scan in patients with suspected pulmonary embolism: a systematic review.

CONTEXT
The clinical validity of using computed tomography (CT) to diagnose peripheral pulmonary embolism is uncertain. Insufficient sensitivity for peripheral pulmonary embolism is considered the principal limitation of CT.


OBJECTIVE
To review studies that used a CT-based approach to rule out a diagnosis of pulmonary embolism.


DATA SOURCES
The medical literature databases of PubMed, MEDLINE, EMBASE, CRISP, metaRegister of Controlled Trials, and Cochrane were searched for articles published in the English language from January 1990 to May 2004.


STUDY SELECTION
We included studies that used contrast-enhanced chest CT to rule out the diagnosis of acute pulmonary embolism, had a minimum follow-up of 3 months, and had study populations of more than 30 patients.


DATA EXTRACTION
Two reviewers independently abstracted patient demographics, frequency of venous thromboembolic events (VTEs), CT modality (single-slice CT, multidetector-row CT, or electron-beam CT), false-negative results, and deaths attributable to pulmonary embolism. To calculate the overall negative likelihood ratio (NLR) of a VTE after a negative or inconclusive chest CT scan for pulmonary embolism, we included VTEs that were objectively confirmed by an additional imaging test despite a negative or inconclusive CT scan and objectively confirmed VTEs that occurred during clinical follow-up of at least 3 months.


DATA SYNTHESIS
Fifteen studies met the inclusion criteria and contained a total of 3500 patients who were evaluated from October 1994 through April 2002. The overall NLR of a VTE after a negative chest CT scan for pulmonary embolism was 0.07 (95% confidence interval [CI], 0.05-0.11); and the negative predictive value (NPV) was 99.1% (95% CI, 98.7%-99.5%). The NLR of a VTE after a negative single-slice spiral CT scan for pulmonary embolism was 0.08 (95% CI, 0.05-0.13); and after a negative multidetector-row CT scan, 0.15 (95% CI, 0.05-0.43). There was no difference in risk of VTEs based on CT modality used (relative risk, 1.66; 95% CI, 0.47-5.94; P = .50). The overall NLR of mortality attributable to pulmonary embolism was 0.01 (95% CI, 0.01-0.02) and the overall NPV was 99.4% (95% CI, 98.7%-99.9%).


CONCLUSION
The clinical validity of using a CT scan to rule out pulmonary embolism is similar to that reported for conventional pulmonary angiography.
Androgen receptor expression relationship with semen variables in infertile men with varicocele.

PURPOSE
Androgen receptor, a member of the nuclear receptor superfamily, has important roles in male reproductive function. It is required for sexual differentiation, pubertal development, spermatogenesis regulation, meiosis completion and spermatocyte transition to haploid round spermatids. We assessed the association of androgen receptor expression and semen variables in infertile men with varicocele.


MATERIALS AND METHODS
A total of 299 men were grouped into healthy, fertile controls, infertile men without varicocele and men with infertility associated with varicocele. A history was obtained, clinical examination and semen analysis were done and reproductive hormones were estimated. Androgen receptor expression and the acrosome reaction were determined in recovered spermatozoa.


RESULTS
Androgen receptor expression was significantly decreased in infertile men with varicocele more than in infertile men without varicocele compared to fertile controls. Androgen receptor correlated positively with sperm count, motility, normal forms, velocity, linear velocity, acrosome reaction and α-glucosidase. It correlated negatively with serum follicle-stimulating hormone and estradiol. Multiple stepwise regression analysis of androgen receptor expression revealed that the sperm acrosome reaction and linearity index were the most affected independent variables.


CONCLUSIONS
Androgen receptor expression was significantly decreased in infertile men with varicocele more than in infertile men without varicocele compared to fertile men. Androgen receptor expression correlated positively with sperm count, motility, normal forms, velocity, linear velocity and acrosome reaction.
Maternal mental health in primary care in five low- and middle-income countries: a situational analysis

BACKGROUND
The integration of maternal mental health into primary health care has been advocated to reduce the mental health treatment gap in low- and middle-income countries (LMICs). This study reports findings of a cross-country situation analysis on maternal mental health and services available in five LMICs, to inform the development of integrated maternal mental health services integrated into primary health care.


METHODS
The situation analysis was conducted in five districts in Ethiopia, India, Nepal, South Africa and Uganda, as part of the Programme for Improving Mental Health Care (PRIME). The analysis reports secondary data on the prevalence and impact of priority maternal mental disorders (perinatal depression, alcohol use disorders during pregnancy and puerperal psychosis), existing policies, plans and services for maternal mental health, and other relevant contextual factors, such as explanatory models for mental illness.


RESULTS
Limited data were available at the district level, although generalizable data from other sites was identified in most cases. Community and facility-based prevalences ranged widely across PRIME countries for perinatal depression (3-50 %) and alcohol consumption during pregnancy (5-51 %). Maternal mental health was included in mental health policies in South Africa, India and Ethiopia, and a mental health care plan was in the process of being implemented in South Africa. No district reported dedicated maternal mental health services, but referrals to specialised care in psychiatric units or general hospitals were possible. No information was available on coverage for maternal mental health care. Challenges to the provision of maternal mental health care included; limited evidence on feasible detection and treatment strategies for maternal mental disorders, lack of mental health specialists in the public health sector, lack of prescribing guidelines for pregnant and breastfeeding women, and stigmatising attitudes among primary health care staff and the community.


CONCLUSIONS
It is difficult to anticipate demand for mental health care at district level in the five countries, given the lack of evidence on the prevalence and treatment coverage of women with maternal mental disorders. Limited evidence on effective psychosocial interventions was also noted, and must be addressed for mental health programmes, such as PRIME, to implement feasible and effective services.
Dose-intensive response-based chemotherapy and radiation therapy for children and adolescents with newly diagnosed intermediate-risk hodgkin lymphoma: a report from the Children's Oncology Group Study AHOD0031.

PURPOSE
The Children's Oncology Group study AHOD0031, a randomized phase III study, was designed to evaluate the role of early chemotherapy response in tailoring subsequent therapy in pediatric intermediate-risk Hodgkin lymphoma. To avoid treatment-associated risks that compromise long-term health and to maintain high cure rates, dose-intensive chemotherapy with limited cumulative doses was used.


PATIENTS AND METHODS
Patients received two cycles of doxorubicin, bleomycin, vincristine, etoposide, cyclophosphamide, and prednisone (ABVE-PC) followed by response evaluation. Rapid early responders (RERs) received two additional ABVE-PC cycles, followed by complete response (CR) evaluation. RERs with CR were randomly assigned to involved-field radiotherapy (IFRT) or no additional therapy; RERs with less than CR were nonrandomly assigned to IFRT. Slow early responders (SERs) were randomly assigned to receive two additional ABVE-PC cycles with or without two cycles of dexamethasone, etoposide, cisplatin, and cytarabine (DECA). All SERs were assigned to receive IFRT.


RESULTS
Among 1,712 eligible patients, 4-year event-free survival (EFS) was 85.0%: 86.9% for RERs and 77.4% for SERs (P < .001). Four-year overall survival was 97.8%: 98.5% for RERs and 95.3% for SERs (P < .001). Four-year EFS was 87.9% versus 84.3% (P = .11) for RERs with CR who were randomly assigned to IFRT versus no IFRT, and 86.7% versus 87.3% (P = .87) for RERs with positron emission tomography (PET) -negative results at response assessment. Four-year EFS was 79.3% versus 75.2% (P = .11) for SERs who were randomly assigned to DECA versus no DECA, and 70.7% versus 54.6% (P = .05) for SERs with PET-positive results at response assessment.


CONCLUSION
This trial demonstrated that early response assessment supported therapeutic titration (omitting radiotherapy in RERs with CR; augmenting chemotherapy in SERs with PET-positive disease). Strategies directed toward improved response assessment and risk stratification may enhance tailoring of treatment to patient characteristics and response.
Oral leukoedema with mucosal desquamation caused by toothpaste containing sodium lauryl sulfate.

E4 CUTIS WWW.CUTIS.COM To the Editor: A 34-year-old woman presented for evaluation of dry mouth and painless peeling of the oral mucosa of 2 months’ duration. She denied any other skin eruptions, dry eyes, vulvar or vaginal pain, or recent hair loss. A recent antinuclear antibodies test was negative. The patient’s medical history was otherwise unremarkable and her current medications included multivitamins only. Oral examination revealed peeling gray-white tissue on the buccal mucosa and mouth floor (Figure 1). After the tissue was manually removed with a tongue blade, the mucosal base was normal in color and texture. The patient denied bruxism, biting of the mucosa or other oral trauma, or use of tobacco or nonsteroidal anti-inflammatory drugs. Biopsies from the buccal mucosa were performed to rule out erosive lichen planus and autoimmune blistering disorders. Microscopy revealed parakeratosis and intracellular edema of the mucosa. An intraepithelial cleft at the parakeratotic surface also was present (Figure 2). Minimal inflammation was noted. Fungal staining and direct immunofluorescence were negative. The gray-white clinical appearance of the oral mucosa resembled leukoedema, but the peeling phenomenon was uncharacteristic. Histologically, leukoedema typically has a parakeratotic and acanthotic epithelium with marked intracellular edema of the spinous layer.1,2 Our patient demonstrated
Question or tone 2? How language experience and linguistic function guide pitch processing

How does language experience shape pitch processing? Do speakers of tone languages, which use pitch to signal lexical contrasts (e.g., Mandarin Chinese) attend to pitch movements more closely than speakers of intonation languages (e.g., English)? Contradictory findings have been reported in the literature. In the current study, we hypothesize that listeners should be particularly attentive to any pitch information that signals meaningful information in the native language. This includes pitch movements signaling lexical contrasts (present in tone languages only) as well as postlexical contrasts (present in all languages). Both Mandarin and Dutch listeners performed speeded ABX match to sample tasks on the same sets of nonsense words. As predicted, the same pitch movements were attended to differentially by the two language populations depending on the role that information played in the native language. Mandarin speakers were more attentive than Dutch listeners to pitch movements as these signaled potential lexical contrasts in Mandarin (but not Dutch). Importantly, Dutch listeners were more attentive to pitch movements signaling postlexical information than to pitch movements signaling no meaningful information. These findings underscore the importance of postlexical information in online speech processing, and explain apparent contradictions in the
Rationale and design of a randomized cluster trial to improve guideline-adherence of secondary preventive drugs prescription after coronary artery bypass grafting in China: Measurement and Improvement Studies of Surgical Coronary Revascularization: Secondary Prevention (MISSION-1) Study.

OBJECTIVES
The benefits of secondary preventive drugs after coronary artery bypass grafting have been thoroughly established. However, the prescription rates of these drugs are low at discharge in China. We sought to evaluate the effectiveness of continuous quality improvement with mobile-based interventions for clinicians on improving the guideline-adherence of secondary preventive drugs prescription.


METHODS AND RESULTS
The quality MISSION-1 study is a cluster-randomized controlled trial. We enrolled 60 hospitals with a bypass surgery volume of more than 30 a year and randomly assigned them into the intervention group or the control group in a 1:1 ratio using minimized random grouping. The intervention group undertakes a series of mobile-based interventions, while the control group maintains a routine practice pattern. All sites consecutively register patients who underwent isolated coronary artery bypass grafting and submit in-hospital data. We require supporting documents regarding prescription information at discharge to adjudicate the outcome measures. The estimated sample size of enrolled patients is 9,600. The primary outcome measure is the prescription rate of statins for eligible patients at discharge. The secondary outcome measures are β-blockers, angiotensin-converting enzyme inhibitors or angiotensin receptor blockers, and optimal medical therapy. MISSION-1 study is now recruiting patients.


CONCLUSIONS
The MISSION-1 study has the potential to identify the effectiveness of interventions on improving secondary prevention adherence at discharge after bypass surgery in China and further disseminate findings to other settings to improve the quality of care.
Tenidap is neuroprotective in a pilocarpine rat model of temporal lobe epilepsy.

BACKGROUND
Tenidap is a liposoluble non-steroidal anti-inflammatory drug that is easily distributed in the central nervous system and also inhibits the production and activity of cyclooxygenase-2 (COX-2) and cytokines in vitro. This study aimed to evaluate the neuroprotective effect of tenidap in a pilocarpine rat model of temporal lobe epilepsy (TLE).


METHODS
Tenidap was administered daily at 10 mg/kg for 10 days following pilocarpine-induced status epilepticus (SE) in male Wistar rats after which prolonged generalized seizures resulted in TLE. After tenidap treatment, spontaneous recurrent seizures (SRSs) were recorded by video monitoring (for 7 hours per day for 14 days). The frequency and severity of the SRSs were observed. Histological and immunocytochemical analyses were used to evaluate the neuroprotective effect of tenidap and detect COX-2 expression, which may be associated with neuronal death.


RESULTS
There were 46.88 ± 10.70 survival neurons in tenidap-SE group, while there were 27.60 ± 5.18 survival neurons in saline-SE group at -2.4 mm field in the CA3 area. There were 37.75 ± 8.78 survival neurons in tenidap-SE group, while there were 33.40 ± 8.14 survival neurons in saline-SE group at -2.4 mm field in the CA1 area. Tenidap treatment significantly reduced neuronal damage in the CA3 area (P < 0.05) and slightly reduced damage in the CA1 area. Tenidap markedly inhibited COX-2 expression in the hippocampus, especially in the CA3 area.


CONCLUSION
Tenidap conferred neuroprotection to the CA3 area in a pilocarpine-induced rat model of TLE by inhibiting COX-2 expression.
Image Resolution Enhancement using Inter-Subband Correlation in Wavelet Domain

Wavelet-based resolution enhancement methods improve the image resolution by estimating the high-frequency band information. In this paper, we propose a new resolution enhancement method using inter-subband correlation in which the sampling phase in DWT is considered. Interpolation filters are designed by analyzing correlations between subbands having different sampling phases in the lower level, and applied to the correlated subbands in the higher level. The filters are estimated under the assumption that correlations between two subbands in the higher level are similar to that in the lower level in DWT. The experimental results show that our proposed method outperforms the conventional interpolation methods including the other wavelet-based methods with respect to peak signal-to-noise-ratio (PSNR) as well as the subjective quality.
PACE – the first placebo controlled trial of paracetamol for acute low back pain: statistical analysis plan

BACKGROUND
Paracetamol (acetaminophen) is recommended in most clinical practice guidelines as the first choice of treatment for low back pain, however there is limited evidence to support this recommendation. The PACE trial is the first placebo controlled trial of paracetamol for acute low back pain. This article describes the statistical analysis plan.


RESULTS
PACE is a randomized double dummy placebo controlled trial that investigates and compares the effect of paracetamol taken in two regimens for the treatment of low back pain. The protocol has been published. The analysis plan was completed blind to study group and finalized prior to initiation of analyses. All data collected as part of the trial were reviewed, without stratification by group, and classified by baseline characteristics, process of care and trial outcomes. Trial outcomes were classified as primary and secondary outcomes. Appropriate descriptive statistics and statistical testing of between-group differences, where relevant, have been planned and described.


CONCLUSIONS
A standard analysis plan was developed for the results of the PACE study. This plan comprehensively describes the data captured and pre-determined statistical tests of relevant outcome measures. The plan demonstrates transparent and verifiable use of the data collected. This a priori plan will be followed to ensure rigorous standards of data analysis are strictly adhered to.


TRIAL REGISTRATION
Australia and New Zealand Clinical Trials Registry ACTRN12609000966291.
Implications of the fit between organizational structure and ERP: A structural contingency theory perspective

Despite the tremendous popularity and great potential, the field of Enterprise Resource Planning (ERP) adoption and implementation is littered with remarkable failures. Though many contributing factors have been cited in the literature, we argue that the integrated nature of ERP systems, which generally requires an organization to adopt standardized business processes reflected in the design of the software, is a key factor contributing to these failures. We submit that the integration and standardization imposed by most ERP systems may not be suitable for all types of organizations and thus the ‘‘fit’’ between the characteristics of the adopting organization and the standardized business process designs embedded in the adopted ERP system affects the likelihood of implementation success or failure. In this paper, we use the structural contingency theory to identify a set of dimensions of organizational structure and ERP system characteristics that can be used to gauge the degree of fit, thus providing some insights into successful ERP implementations. Propositions are developed based on analyses regarding the success of ERP implementations in different types of organizations. These propositions also provide directions for future research that might lead to prescriptive guidelines for managers of organizations contemplating implementing ERP systems. r 2008 Elsevier Ltd. All rights reserved.
Improving Person Tracking Using an Inexpensive Thermal Infrared Sensor

This paper proposes a person tracking framework using a scanning low-resolution thermal infrared (IR) sensor colocated with a wide-angle RGB camera. The low temporal and spatial resolution of the low-cost IR sensor make it unable to track moving people and prone to false detections of stationary people. Thus, IR-only tracking using only this sensor would be quite problematic. We demonstrate that despite the limited capabilities of this low-cost IR sensor, it can be used effectively to correct the errors of a real-time RGB camera-based tracker. We align the signals from the two sensors both spatially (by computing a pixel-to-pixel geometric correspondence between the two modalities) and temporally (by modeling the temporal dynamics of the scanning IR sensor), which enables multi-modal improvements based on judicious application of elementary reasoning. Our combined RGB+IR system improves upon the RGB camera-only tracking by: rejecting false positives, improving segmentation of tracked objects, and correcting false negatives (starting new tracks for people that were missed by the camera-only tracker). Since we combine RGB and thermal information at the level of RGB camera-based tracks, our method is not limited to the particular camera-based tracker that we used in our experiments. Our method could improve the results of any tracker that uses RGB camera input alone. We collect a new dataset and demonstrate the superiority of our method over RGB camera-only tracking.
Force and Position Control System for Freehand Ultrasound

A hand-held force-controlled ultrasound probe has been developed for medical imaging applications. The probe-patient contact force can be held constant to improve image stability, swept through a range, or cycled. The mechanical portion of the device consists of a ball screw linear actuator driven by a servo motor, along with a load cell, accelerometer, and limit switches. The performance of the system was assessed in terms of the frequency response to simulated sonographer hand motion and in hand-held image feature tracking during simulated patient motion. The system was found to attenuate contact force variation by 97% at 0.1 Hz, 83% at 1 Hz, and 33% 10 Hz, a range that spans the typical human hand tremor frequency spectrum. In studies with 15 human operators, the device applied the target contact force with ten times less variation than in conventional ultrasound imaging. An ergonomic, human-in-the-loop, imaging-workflow enhancing control scheme, which combines both force- and position-control, permits smooth making and breaking of probe-patient contact, and helps the operator keep the probe centered within its range of motion. By controlling ultrasound probe contact force and consequently the amount of tissue deformation, the system enhances the repeatability, usability, and diagnostic capabilities of ultrasound imaging.