LLukas22/scidocs huggingface dataset:
Neoadjuvant therapy for downstaging of locally advanced hilar cholangiocarcinoma: a systematic review.

BACKGROUND
Hilar cholangiocarcinoma is a rare but highly lethal type of cancer. A minority of patients present with resectable disease. Surgery remains the only treatment modality offering a chance of long-term survival. Unresectable patients are typically offered palliative treatment. The aim of this systematic review was to summarize the evidence for neoadjuvant therapy followed by surgical resection in patients presenting with hilar cholangiocarcinoma.


METHODS
Cochrane databases, Medline, PubMed and EMBASE were systematically searched to identify articles describing neoadjuvant therapy and surgical resection or re-assessment of resectability in patients with hilar cholangiocarcinoma. Included were all articles with original research. Study selection and data extraction were performed separately by two reviewers using a standardized protocol.


RESULTS
From 732 articles 8 full text articles and 2 abstracts met the inclusion criteria. The 2 abstracts and 1 full text article were case reports, 3 articles were retrospective and 4 were prospective studies (2 phase I and 2 phase II studies). Photodynamic therapy, chemotherapy and radiation therapy were used in various indications in populations that included patients with hilar cholangiocarcinoma, some of which were primarily unresectable. Overall quality of articles was limited.


CONCLUSION
Current evidence suggests that neoadjuvant therapy in patients with unresectable hilar cholangiocarcinoma can be performed safely and in a selected group of patients can lead to subsequent surgical R0 resection. Surgical resection of downstaged patients should be assessed in properly designed phase II studies.
Neutrophilic dermatoses-Part I Dermatoses neutrofílicas – Parte I

This article addresses neutrophilic dermatoses, thus complementing the previous article (part I). The following dermatoses are introduced and discussed: subcorneal pustular dermatosis (Sneddon-Wilkinson disease), dermatitis cruris pustulosa et atrophicans, acute generalized exanthematous pustulosis, continuous Hallopeau acrodermatitis, palmoplantar pustulosis, infantile acropustulosis, Andrews' pustular bacteride and eosinophilic pustular folliculitis. A brief review of neutrophilic dermatoses in pediatric patients is also conducted.
“A year-long, fortnightly, observational survey in three European countries of patients with respiratory allergies induced by house dust mites: Methodology, demographics and clinical characteristics”

BACKGROUND
House dust mite (HDM) allergens constitute the leading trigger for the symptoms of persistent respiratory allergies (such as allergic rhinitis and asthma). However, the fluctuating, pernicious nature of the symptoms has given rise to a perception that HDM-induced respiratory allergy is not a "real" disease.


METHODS
In order to assess the self-reported disease profile and behaviour of adult patients with a self-reported history of severe, poorly controlled, physician-diagnosed HDM respiratory allergy, we performed an observational, international, multicentre survey in three European countries (France, Italy and Spain). Participants were included in the survey if they passed a short Internet-based screening questionnaire. Following completion of a detailed post-inclusion questionnaire, 28 fortnightly telephone interviews were used to gather extensive data on the participants' symptom prevalence and intensity, medical consultations, disease burden, quality of life, and medication use from late May 2012 to early July 2013.


RESULTS
Twenty-two thousand nine hundred ninety five individuals completed the Internet screening questionnaire and 339 respondents (67 % female) met all the inclusion criteria. 313 of the 339 (92 %) completed the post-inclusion questionnaire (n = 114 in Italy, 92 in France and 107 in Spain). The median time since the first symptoms of HDM allergy was over 13 years in all three countries. The response rate for the fortnightly interviews averaged 75 % (range: 29 to 97 %). The reported fortnightly prevalence of nasal and ocular symptoms peaked in the autumn (September to November) and spring (March to May). These peaks in prevalence coincided with increased reports of symptom worsening and higher physician consultation rates. In participants not allergic to pollen, the autumn and spring peaks were accompanied by a third peak in late December 2012. Very few participants reported that their symptoms had never improved (4 %) or never worsened (11 %) during the survey period.


CONCLUSIONS
In a survey in France, Italy and Spain, patients with severe HDM-induced respiratory allergies experienced a complex set of changing, troublesome symptoms throughout the year, with peaks in spring, autumn and (to a lesser extent) mid-winter.
Clinical tests to diagnose lumbar segmental instability: a systematic review.

STUDY DESIGN
Systematic literature review.


OBJECTIVES
To evaluate the diagnostic accuracy of clinical tests used to diagnose patients with structural lumbar segmental instability (LSI).


BACKGROUND
Patients with structural LSI represent an important, identifiable subgrouping of individuals with low back pain. Numerous clinical tests have been proposed to diagnose structural LSI; however, data on the diagnostic accuracy of these tests have not yet been evaluated through a systematic review of the literature.


METHODS
A systematic review was conducted in 6 electronic databases for diagnostic accuracy studies, published between January 1950 and March 2010, that evaluated clinical tests against radiological diagnosis of structural LSI. The diagnostic accuracy of the clinical tests from the retrieved articles was independently evaluated, reviewed, and quality scored using the QUADAS tool.


RESULTS
Four articles and a total of 11 clinical tests used in the diagnosis of structural LSI met the study inclusion criteria. The majority of tests had high specificity but low sensitivity, with positive likelihood ratios ranging from very small to moderate. QUADAS scores ranged from 16 to 25 out of a possible 26. The passive lumbar extension test was the most accurate clinical test, with high sensitivity (84%), specificity (90%), and a positive likelihood ratio of 8.8 (95% CI: 4.5, 17.3), indicating that this clinical test may be useful in the differential diagnosis of structural LSI.


CONCLUSION
This systematic review found that the majority of clinical tests routinely employed to diagnose structural LSI demonstrated only limited ability to do so. The results do, however, indicate that the passive lumbar extension test may be useful in orthopaedic clinical practice to diagnose structural LSI. Additional research is required to further validate its use for diagnosing structural LSI in all populations of those with low back pain.


LEVEL OF EVIDENCE
Diagnosis, level 2a.
Maturity-associated variation in the growth and functional capacities of youth football (soccer) players 13–15 years

The objective was to estimate the contribution of experience, body size and maturity status to variation in the functional capacities of adolescent football (soccer) players. The sample included 69 players 13.2–15.1 years of age from three clubs which competed in the highest division for their age group in the first Portuguese national division. Height and weight were measured and stage of pubic hair development was assessed at clinical examination. The number of years of experience in football was obtained at interview. Three tests of functional capacity were administered: 30-m dash (running speed), vertical jump (explosive power) and a yo-yo intermittent endurance test (aerobic resistance). Multiple linear regression analysis was used to estimate the relative contributions of age, stage of sexual maturity, height, weight and years of formal training in football to the three indicators of functional capacity. Stage of puberty, body size and years of training accounted for 21% to 50% of the variance in the three tasks. Sexual maturity status was the primary contributor to the variance in the intermittent shuttle run, whereas weight and height were the primary contributors to the explained variance in the 30-m dash and vertical jump, respectively. In conclusion, biological maturity status significantly influences the functional capacity of adolescent football players 13–15 years of age. Training is a significant contributor to aerobic resistance, whereas weight and height are significant contributors to the sprint and vertical jump, respectively.
Inter-Industry Wage Differentials in Ireland

This paper investigates inter-industry wage differentials in Ireland, taking advantage of access to a dataset that is uniquely suitable for this purpose, the 1996 Structure of Earnings Survey. This allows us to measure not simply overall differentials in the average wage across sectors, but also the extent to which these are associated with a range of employee, job, employer and sectoral characteristics. The results show that there are substantial differences in earnings across industrial sectors in Ireland, predominantly but not only reflecting differences in measured human capital of workers and attributes of their jobs. While unobserved individual and job characteristics may underpin the remaining differentials, efficiency wage or rent-sharing could also be playing a role. Including a range of firm and sectoral characteristics relevant to the latter does not markedly alter the scale of inter-industry differentials, but firm fixed effects seem important. The dispersion of wages across industries, controlling for observed employee, job and employer characteristics, is quite high in Ireland compared to other industrialised countries.
Learning models for visual 3D localization with implicit mapping

We propose a formulation of visual localization that does not require construction of explicit maps in the form of point clouds or voxels. The goal is to learn an implicit representation of the environment at a higher, more abstract level, for instance that of objects. To study this approach we consider procedurally generated Minecraft worlds, for which we can generate visually rich images along with camera pose coordinates. We first show that Generative Query Networks (GQNs) enhanced with a novel attention mechanism can capture the visual structure of 3D scenes in Minecraft, as evidenced by their samples. We then apply the models to the localization problem, investigating both generative and discriminative approaches, and compare the different ways in which they each capture task uncertainty. Our results show that models with implicit mapping are able to capture the underlying 3D structure of visually complex scenes, and use this to accurately localize new observations, paving the way towards future applications in sequential localization. Supplementary video available at https://youtu.be/iHEXX5wXbCI.
An Approximate Minimum Degree Ordering Algorithm

An Approximate Minimum Degree ordering algorithm (AMD) for preordering a symmetric sparse matrix prior to numerical factorization is presented. We use techniques based on the quotient graph for matrix factorization that allow us to obtain computationally cheap bounds for the minimum degree. We show that these bounds are often equal to the actual degree. The resulting algorithm is typically much faster than previous minimum degree ordering algorithms, and produces results that are comparable in quality with the best orderings from other minimum degree algorithms. ENSEEIHT-IRIT, Toulouse, France. email: amestoy@enseeiht.fr. Computer and Information Sciences Department University of Florida, Gainesville, Florida, USA. phone: (904) 392-1481, email: davis@cis.ufl.edu. Technical reports and matrices are available via the World Wide Web at http://www.cis.ufl.edu/̃ davis, or by anonymous ftp at ftp.cis.ufl.edu:cis/tech-reports. Support for this project was provided by the National Science Foundation (ASC-9111263 and DMS-9223088). Portions of this work were supported by a post-doctoral grant from CERFACS. Rutherford Appleton Laboratory, Chilton, Didcot, Oxon. 0X11 0QX England, and European Center for Research and Advanced Training in Scientific Computation (CERFACS), Toulouse, France. email: isd@letterbox.rl.ac.uk. Technical reports, information on the Harwell Subroutine Library, and matrices are available via the World Wide Web at http://www.cis.rl.ac.uk/struct/ARCD/NUM.html, or by anonymous ftp at seamus.cc.rl.ac.uk/pub.
Designing an Energy Storage System Fuzzy PID Controller for Microgrid Islanded Operation

Recently, interest in microgrids, which are composed of distributed generation (DG), distributed storage (DS), and loads, has been growing as a potentially effective clean energy system to mitigate against climate change. The microgrid is operated in the grid-connected mode and the islanded mode according to the conditions of the upstream power grid. The role of the energy storage system (ESS) is especially important to maintain constant the frequency and voltage of an islanded microgrid. For this reason, various approaches for ESS control have been put forth. In this paper, a fuzzy PID controller is proposed to improve the frequency control performance of the ESS. This fuzzy PID controller consists of a fuzzy logic controller and a conventional PI controller, connected in series. The fuzzy logic controller has two input signals, and then the output signal of the fuzzy logic controller is the input signal of the conventional PI controller. For comparison of control performance, gains of each PI controller and fuzzy PID controller are tuned by the particle swam optimization (PSO) algorithm. In the simulation study, the control performance of the fuzzy PID was also tested under various operating conditions using the PSCAD/EMTDC simulation platform.
Inquiry teaching in mathematics through history of mathematics

We explain how history of mathematics can function as a means for enacting inquiry learning activities in mathematics as a scientific subject. It will be discussed how students develop informed conception about i) the epistemology of mathematics, ii) of how mathematicians produce mathematical knowledge, and iii) what kind of questions that drive mathematical research. We give examples from the mathematics education at Roskilde University and we show how (teacher) students from this program are themselves capable of using history to establish inquiry learning environments in mathematics in high school. The realization is argued for in the context of an explicit-reflective framework in the sense of Abd-El-Khalick (2013) and his work in science education.
A comparison between concept maps, mind maps, conceptual diagrams, and visual metaphors as complementary tools for knowledge construction and sharing

Received: 8 February 2006 Revised: 31 March 2006 Accepted: 13 April 2006 Online publication date: 22 June 2006 Abstract In this article, Novak's concept mapping technique is compared to three other types of visualization formats, namely mind maps, conceptual diagrams, and visual metaphors. The application parameters and the respective advantages and disadvantages of each format for learning and knowledge sharing are reviewed and discussed. It is argued that the combination of these four visualization types can play to the strength of each one. The article then provides real-life examples from such a use in undergraduate and graduate university teaching. The results provide first indications that the different visualization formats can be used in complementary ways to enhance motivation, attention, understanding and recall. The implications for a complementary use of these visualization formats in class room and meeting contexts are discussed and a future research agenda in this domain is articulated. Information Visualization (2006) 5, 202--210. doi:10.1057/palgrave.ivs.9500131
Exercise training but not rosiglitazone improves endothelial function in prediabetic patients with coronary disease.

BACKGROUND
Impaired glucose tolerance (IGT) is associated with endothelial dysfunction and upregulation of inflammatory markers, which is potentially reversible by adequate treatment. It was our aim to compare the impact of exercise training with that of rosiglitazone on endothelial function and inflammatory markers in patients with IGT and coronary artery disease (CAD).


METHODS
Patients with IGT and CAD were randomly assigned to either exercise training (n=13), rosiglitazone (8 mg; n=11), or a control group (n=10). During the first week, exercise training consisted of 6 x 15 min/d followed by three weeks of 30 min/d submaximal ergometer exercise. In addition, group exercise training of 1 h was performed twice per week.


RESULTS
After 4 weeks, triglycerides and uric acid were significantly lower in the exercise group whereas fasting glucose, HbA1c, low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol, C-reactive protein, fibrinogen, and body mass index did not differ between groups. In the exercise group, exercise capacity (123+/-33 vs. 144+/-31 W; P=0.006) and endothelium-dependent, flow-mediated vasodilatation (P<0.01) increased significantly, whereas in the rosiglitazone group and in the control group (P=n.s.) no changes were seen.


CONCLUSION
In patients with IGT and CAD, 4 weeks of exercise training exert significant and superior improvement of endothelium-dependent vasodilatation as compared with rosiglitazone therapy or usual care. This finding should be seen as an even further encouragement to recommend and, where available, prescribe exercise training to our patients.
Tuning in to European Dissonance

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Increase in urinary leukotriene LTE4 levels in acute asthma: correlation with airflow limitation.

BACKGROUND
Leukotrienes play a key role in the pathophysiology of chronic asthma. Activation of leukotriene pathways is accompanied by rises in detectable urinary levels of leukotriene E4 (LTE4). The relationship between urinary LTE4 levels and factors associated with acute asthma has not been determined.


METHODS
Adults aged 15-54 years presenting with moderate to severe acute asthma were evaluated at emergency departments in 16 US sites. Forced expiratory volume in 1 second (FEV1) was measured during the first 60 minutes after arrival and at specified times until discharge or admission. Urine samples for measurement of LTE4 levels were obtained either on arrival at the study site and/or before discharge. Patients were seen 2 weeks later for follow up, at which time repeat FEV1 measurements and urine samples for LTE4 were obtained.


RESULTS
One hundred and eighty four patients were evaluated; LTE4 results from both the acute and follow up periods were available for analysis in 146. Urinary LTE4 levels were increased during asthma exacerbations compared with levels obtained 2 weeks later (geometric means 111.7 and 75.6 pg/mg creatinine, respectively, mean percentage change -32.3; 95% confidence interval (CI) for the mean percentage change -39.6 to -24.3, p<0.001). The correlation between improvement in FEV1 and decline in LTE4 over the 2 week interval was significant (p<0.001, r=0.43).


CONCLUSIONS
Activation of leukotriene pathways in acute asthma is correlated with the degree of airflow obstruction, and resolution of the asthma exacerbation is associated with a reduction in leukotriene levels.
Light my fire

As S&S counts down to the September issue's once-a-decade poll to find the Greates Film of All Time, French critic Nicole Brenez makes the case for one of the key revolutionary activist films of the 1960s, "The Hour of the Furnaces"
Virtual Reality Goes to War: A Brief Review of the Future of Military Behavioral Healthcare

Numerous reports indicate that the incidence of posttraumatic stress disorder (PTSD) in returning OEF/OIF military personnel is creating a significant healthcare challenge. These findings have served to motivate research on how to better develop and disseminate evidence-based treatments for PTSD. Virtual Reality delivered exposure therapy for PTSD has been previously used with reports of positive outcomes. This article details how virtual reality applications are being designed and implemented across various points in the military deployment cycle to prevent, identify and treat combat-related PTSD in OIF/OEF Service Members and Veterans. The summarized projects in these areas have been developed at the University of Southern California Institute for Creative Technologies, a U.S. Army University Affiliated Research Center, and this paper will detail efforts to use virtual reality to deliver exposure therapy, assess PTSD and cognitive function and provide stress resilience training prior to deployment.
Robust Physical-World Attacks on Deep Learning Models.

Recent studies show that the state-of-the-art deep neural networks (DNNs) are vulnerable to adversarial examples, resulting from small-magnitude perturbations added to the input. Given that that emerging physical systems are using DNNs in safety-critical situations, adversarial examples could mislead these systems and cause dangerous situations. Therefore, understanding adversarial examples in the physical world is an important step towards developing resilient learning algorithms. We propose a general attack algorithm, Robust Physical Perturbations (RP2), to generate robust visual adversarial perturbations under different physical conditions. Using the real-world case of road sign classification, we show that adversarial examples generated using RP2 achieve high targeted misclassification rates against standard-architecture road sign classifiers in the physical world under various environmental conditions, including viewpoints. Due to the current lack of a standardized testing method, we propose a two-stage evaluation methodology for robust physical adversarial examples consisting of lab and field tests. Using this methodology, we evaluate the efficacy of physical adversarial manipulations on real objects. With a perturbation in the form of only black and white stickers, we attack a real stop sign, causing targeted misclassification in 100% of the images obtained in lab settings, and in 84.8% of the captured video frames obtained on a moving vehicle (field test) for the target classifier.
Evidence based physical activity for school-age youth.

OBJECTIVES
To review the effects of physical activity on health and behavior outcomes and develop evidence-based recommendations for physical activity in youth.


STUDY DESIGN
A systematic literature review identified 850 articles; additional papers were identified by the expert panelists. Articles in the identified outcome areas were reviewed, evaluated and summarized by an expert panelist. The strength of the evidence, conclusions, key issues, and gaps in the evidence were abstracted in a standardized format and presented and discussed by panelists and organizational representatives.


RESULTS
Most intervention studies used supervised programs of moderate to vigorous physical activity of 30 to 45 minutes duration 3 to 5 days per week. The panel believed that a greater amount of physical activity would be necessary to achieve similar beneficial effects on health and behavioral outcomes in ordinary daily circumstances (typically intermittent and unsupervised activity).


CONCLUSION
School-age youth should participate daily in 60 minutes or more of moderate to vigorous physical activity that is developmentally appropriate, enjoyable, and involves a variety of activities.