LLukas22/scidocs huggingface dataset:
The feasibility and acceptability of a diet and exercise trial in overweight and obese black breast cancer survivors: The Stepping STONE study.

PURPOSE
Black breast cancer survivors have high rates of obesity and low physical activity levels. Little is known about the acceptability and feasibility of interventions in this population.


OBJECTIVE
A two-arm RCT was launched to assess the efficacy of a culturally targeted 12-week multimodal lifestyle intervention in overweight and obese black survivors.


METHODS
Intervention components included nutrition education, exercise groups, and survivor-led motivational interviewing phone sessions. The analytic sample included women who completed the trial (intervention n=10; control n=12). Anthropometric measures, physical activity, and VO2max were assessed at baseline and follow-up. Change scores (intervention vs. control) were assessed with Wilcoxon rank-sum tests. A process evaluation assessed intervention acceptability.


RESULTS
Overall adherence was 70% and overall satisfaction was high (86%). Despite the 5% weight loss target, the intervention group lost 0.8% but BMI improved. Total physical activity levels increased in the intervention vs. control arm (+3501METmin/week vs. +965METmin/week, respectively). VO2max improved in the intervention group (+0.10±1.03kg/L/min). Intervention participants reduced energy intake (-207.3±31.5kcals) and showed improvements in fat intake (-15.5±3.8g), fiber (+3.2±1.2g) and % energy from fat (-4.8±3.1%). Survivors suggested providing diet/exercise information within a cancer context.


CONCLUSIONS
Group and individualized intervention strategies are acceptable to black survivors. Observed differences between self-report and objective outcomes may suggest reporting bias or changes in body composition. Increasing supervised intervention components and assessment of body composition will be important for future trials.
165-GHz Transceiver in SiGe Technology

Two D-band transceivers, with and without amplifiers and static frequency divider, transmitting simultaneously in the 80-GHz and 160-GHz bands, are fabricated in SiGe HBT technology. The transceivers feature an 80-GHz quadrature Colpitts oscillator with differential outputs at 160 GHz, a double-balanced Gilbert-cell mixer, 170-GHz amplifiers and broadband 70-GHz to 180-GHz vertically stacked transformers for single-ended to differential conversion. For the transceiver with amplifiers and static frequency divider, which marks the highest level of integration above 100 GHz in silicon, the peak differential down-conversion gain is -3 dB for RF inputs at 165 GHz. The single-ended, 165-GHz transmitter output generates -3.5 dBm, while the 82.5-GHz differential output power is +2.5 dBm. This transceiver occupies 840 mum times 1365 mum, is biased from 3.3 V, and consumes 0.9 W. Two stand-alone 5-stage amplifiers, centered at 140 GHz and 170 GHz, were also fabricated showing 17 dB and 15 dB gain at 140 GHz and 170 GHz, respectively. The saturated output power of the amplifiers is +1 dBm at 130 GHz and 0 dBm at 165 GHz. All circuits were characterized over temperature up to 125degC. These results demonstrate for the first time the feasibility of SiGe BiCMOS technology for circuits in the 100-180-GHz range.
Krishi Ville — Android based solution for Indian agriculture

Information and Communication Technology (ICT) in agriculture is an emerging field focusing on the enhancement of agricultural and rural development in India. It involves innovative applications using ICT in the rural domain. The advancement of ICT can be utilized for providing accurate and timely relevant information and services to the farmers, thereby facilitating an environment for remunerative agriculture. This paper describes a mobile based application for farmers which would help them in their farming activities. We propose an android based mobile application — Krishi Ville which would take care of the updates of the different agricultural commodities, weather forecast updates, agricultural news updates. The application has been designed taking indian farming in consideration.
The study on the epidemiology of psychological, alimentary health and nutrition (SEPAHAN): Overview of methodology

1 Integrative Functional Gastroenterology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. 2 Food Security Research Center And Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran. 3 Psychosomatic Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. 4 Behavioral Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. 5 Integrative Functional Gastroenterology Research Center And Psychosomatic Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. 6 University of Adelaide, Discipline of Medicine, Adelaide, Australia. 7 Discipline of Psychiatry, University of Sydney And Department of Psychiatry, Westmead Hospital, Sydney, New South Wales, Australia. 8 Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, United States And Faculty of Health, University of Newcastle, Callaghan, NSW 2308, Australia.
A 96-GHz Ortho-Mode Transducer for the Polatron

We describe the design, simulation, fabrication, and performance of a 96-GHz ortho-mode transducer (OMT) to be used for the Polatron—a bolometric receiver with polarization capability. The OMT has low loss, good isolation, and moderately broad bandwidth, and its performance closely resembles simulation results.
Low-Load Bench Press Training to Fatigue Results in Muscle Hypertrophy Similar to High-Load Bench Press Training

The purpose of this study was to determine whether the training responses observed with low-load resistance exercise to volitional fatigue translates into significant muscle hypertrophy, and compare that response to high-load resistance training. Nine previously untrained men (aged 25 [SD 3] years at the beginning of the study, standing height 1.73 [SD 0.07] m, body mass 68.9 [SD 8.1] kg) completed 6 weeks of high load-resistance training (HL-RT) (75% of one repetition maximal [1RM], 3-sets, 3x/wk) followed by 12 months of detraining. Following this, subjects completed 6 weeks of low load-resistance training (LL-RT) to volitional fatigue (30% 1 RM, 4 sets, 3x/wk). Increases (p < 0.05) in magnetic resonance imaging-measured triceps brachii and pectoralis major muscle cross-sectional areas were similar for both HL-RT (11.9% and 17.6%, respectively) and LL-RT (9.8% and 21.1%, respectively). In addition, both groups increased (p < 0.05) 1RM and maximal elbow extension strength following training; however, the percent increases in 1RM (8.6% vs. 21.0%) and elbow extension strength (6.5% vs. 13.9%) were significantly (p < 0.05) lower with LL-RT. Both protocols elicited similar increases in muscle cross-sectional area, however differences were observed in strength. An explanation of the smaller relative increases in strength may be due to the fact that detraining after HL-RT did not cause strength values to return to baseline levels thereby producing smaller changes in strength. In addition, the results may also suggest that the consistent practice of lifting a heavy load is necessary to maximize gains in muscular strength of the trained movement. These results demonstrate that significant muscle hypertrophy can occur without high-load resistance training and suggests that the focus on percentage of external load as the important deciding factor on muscle hypertrophy is too simplistic and inappropriate.
Treating a Sex Addict Through Marital Sex Therapy

The treatment of sexual addiction can be viewed within the context of addiction and family therapy. A case of sexual addiction is presented and an intervention model is explicated. The application of the model emphasizes the importance of family participation in the treatment. This article describes the family treatment of a "sex addict." This term was popularized by Patrick Carnes in his highly-publicized book Out of the Shadows: Understanding Sexual Addiction (Carnes, 1983). Whether or not one can precisely define addictive sex, it is clear some people admit they cannot control their sexual behavior to the point it seriously interferes with their lives in terms of health, occupation, or family (Edwards, 1986). Others prefer to label these behavioral patterns as sexual compulsions (Quadland, 1985) or simply as problems of sexual control (Coleman, 1986). Some authorities are concerned the term is too value-laden, nonspecific, and assumes falsely that there is an accepted definition of normal sexual behavior (Coleman, 1986; Edwards, 1986). Carnes (1986) responds by saying people label themselves: "The fact remains that a significant number of people have identified themselves as sexual addicts: people whose sexual behavior has become 'unstoppable' despite serious consequences" (p. 4). Before describing a particular case, the author will make a few remarks about the interface of family therapy and the addiction field generally and about the etiology of sexual addiction specifically.
Interaction Networks for Learning about Objects, Relations and Physics

Reasoning about objects, relations, and physics is central to human intelligence, and 1 a key goal of artificial intelligence. Here we introduce the interaction network, a 2 model which can reason about how objects in complex systems interact, supporting 3 dynamical predictions, as well as inferences about the abstract properties of the 4 system. Our model takes graphs as input, performs objectand relation-centric 5 reasoning in a way that is analogous to a simulation, and is implemented using 6 deep neural networks. We evaluate its ability to reason about several challenging 7 physical domains: n-body problems, rigid-body collision, and non-rigid dynamics. 8 Our results show it can be trained to accurately simulate the physical trajectories of 9 dozens of objects over thousands of time steps, estimate abstract quantities such 10 as energy, and generalize automatically to systems with different numbers and 11 configurations of objects and relations. Our interaction network implementation 12 is the first general-purpose, learnable physics engine, and a powerful general 13 framework for reasoning about object and relations in a wide variety of complex 14 real-world domains. 15
L1000FWD: fireworks visualization of drug-induced transcriptomic signatures

Motivation
As part of the NIH Library of Integrated Network-based Cellular Signatures program, hundreds of thousands of transcriptomic signatures were generated with the L1000 technology, profiling the response of human cell lines to over 20 000 small molecule compounds. This effort is a promising approach toward revealing the mechanisms-of-action (MOA) for marketed drugs and other less studied potential therapeutic compounds.


Results
L1000 fireworks display (L1000FWD) is a web application that provides interactive visualization of over 16 000 drug and small-molecule induced gene expression signatures. L1000FWD enables coloring of signatures by different attributes such as cell type, time point, concentration, as well as drug attributes such as MOA and clinical phase. Signature similarity search is implemented to enable the search for mimicking or opposing signatures given as input of up and down gene sets. Each point on the L1000FWD interactive map is linked to a signature landing page, which provides multifaceted knowledge from various sources about the signature and the drug. Notably such information includes most frequent diagnoses, co-prescribed drugs and age distribution of prescriptions as extracted from the Mount Sinai Health System electronic medical records. Overall, L1000FWD serves as a platform for identifying functions for novel small molecules using unsupervised clustering, as well as for exploring drug MOA.


Availability and implementation
L1000FWD is freely accessible at: http://amp.pharm.mssm.edu/L1000FWD.


Supplementary information
Supplementary data are available at Bioinformatics online.
Duality for differential games and optimal control

A class of linear differential games is shown to be equivalent to some optimalcontrol problems; the body of available concepts and results for the latter, involving time-optimality, uniqueness of optimal controls, feedback controls, can thus be brought to bear on the former. In this paper, the emphasis is on the reduction rather than on the consequences. In particular, we can include rather general forms of exterior state constraints, even though the interesting results now known treat control systems constrained to coset spaces [1], [5]. The trend of this paper is the exact opposite of Isaacs' natural interpretation of differential games as extension of the optimal control problem. A further implication is that the games treated are valueless, in that problems of value (existence and its value) do not intrude themselves.
Lambda-calculus models of programming languages.

Two aspect of programming languages, recursive definitions and type declarations are analyzed in detail. Church's %-calculus is used as a model of a programming language for purposes of the analysis. The main result on recursion is an analogue to Kleene's first recursion theorem: If A = FA for any %-expressions A and F, then A is an extension of YF in the sense that if E[YF], any expression containing YF, has a normal form then E[YF] = E[A]. Y is Curry's paradoxical combinator. The result is shown to be invariant for many different versions of Y. A system of types and type declarations is developed for the %-calculus and its semantic assumptions are identified. The system is shown to be adequate in the sense that it permits a preprocessor to check formulae prior to evaluation to prevent type errors. It is shown that any formula with a valid assignment of types to all its subexpressions must have a normal form. Thesis Supervisor: John M. Wozencraft Title: Professor of Electrical Engineering
The radial temperature profile of the solar wind: SOLAR WIND RADIAL TEMPERATURE PROFILE

[1] The Voyager data show a decrease in temperature in the inner heliosphere, an increase in temperature from 30– 50 AU, a decrease from 50–63 AU, followed by another increase from 63–68 AU. Models of pickup proton heating predict a monotonic temperature rise beyond about 30 AU but do not account for the smaller scale (few AU) temperature variations. At 1 AU, the solar wind temperature is a strong function of the solar wind speed. We find that incorporating a temperature dependence on speed into the pickup proton heating results can reproduce much of the smaller-scale temperature variation observed out to 68 AU. The same speed-temperature dependence provides good fits to data from both the outer heliosphere and from near Earth. Since a large fraction of the proton energy results from heating, this work implies that the heating rate is a function of the speed.
Perceptions and Practices regarding Breastfeeding among Postnatal Women at a District Tertiary Referral Government Hospital in Southern India

Background. Breastfeeding is the optimal method for achieving a normal growth and development of the baby. This study aimed to study mothers' perceptions and practices regarding breastfeeding in Mangalore, India. Methodology. A cross-sectional study of 188 mothers was conducted using a structured proforma. Results. Importance of breast feeding was known to most mothers. While initiation of breast feeding within one hour of birth was done by majority of mothers, few had discarded colostrum and adopted prelacteal feeding. Mothers opined that breast feeding is healthy for their babies (96.3%) and easier than infant feeding (79.8%), does not affect marital relationship (51%), and decreases family expenditure (61.1%). However, there were poor perceptions regarding the advantages of breast milk with respect to nutritive value, immune effect, and disease protection. Few respondents reported discontinuation of breastfeeding in previous child if the baby had fever/cold (6%) or diarrhea (18%) and vomiting (26%). There was a statistically significant association between mother's educational level and perceived importance of breastfeeding and also between the mode of delivery and initiation of breast feeding (p < 0.05). Conclusion. Importance of breast feeding was known to most mothers. Few perceptions related to breast milk and feeding along with myths and disbeliefs should be rectified by health education.
Tofacitinib or adalimumab versus placebo in rheumatoid arthritis.

BACKGROUND
Tofacitinib (CP-690,550) is a novel oral Janus kinase inhibitor that is being investigated for the treatment of rheumatoid arthritis.


METHODS
In this 12-month, phase 3 trial, 717 patients who were receiving stable doses of methotrexate were randomly assigned to 5 mg of tofacitinib twice daily, 10 mg of tofacitinib twice daily, 40 mg of adalimumab once every 2 weeks, or placebo. At month 3, patients in the placebo group who did not have a 20% reduction from baseline in the number of swollen and tender joints were switched in a blinded fashion to either 5 mg or 10 mg of tofacitinib twice daily; at month 6, all patients still receiving placebo were switched to tofacitinib in a blinded fashion. The three primary outcome measures were a 20% improvement at month 6 in the American College of Rheumatology scale (ACR 20); the change from baseline to month 3 in the score on the Health Assessment Questionnaire-Disability Index (HAQ-DI) (which ranges from 0 to 3, with higher scores indicating greater disability); and the percentage of patients at month 6 who had a Disease Activity Score for 28-joint counts based on the erythrocyte sedimentation rate (DAS28-4[ESR]) of less than 2.6 (with scores ranging from 0 to 9.4 and higher scores indicating greater disease activity).


RESULTS
At month 6, ACR 20 response rates were higher among patients receiving 5 mg or 10 mg of tofacitinib (51.5% and 52.6%, respectively) and among those receiving adalimumab (47.2%) than among those receiving placebo (28.3%) (P<0.001 for all comparisons). There were also greater reductions in the HAQ-DI score at month 3 and higher percentages of patients with a DAS28-4(ESR) below 2.6 at month 6 in the active-treatment groups than in the placebo group. Adverse events occurred more frequently with tofacitinib than with placebo, and pulmonary tuberculosis developed in two patients in the 10-mg tofacitinib group. Tofacitinib was associated with an increase in both low-density and high-density lipoprotein cholesterol levels and with reductions in neutrophil counts.


CONCLUSIONS
In patients with rheumatoid arthritis receiving background methotrexate, tofacitinib was significantly superior to placebo and was numerically similar to adalimumab in efficacy. (Funded by Pfizer; ORAL Standard ClinicalTrials.gov number, NCT00853385.).
Interval exchange transformations: Applications of Keane's construction and disjointness

Interval Exchange Transformations: Applications of Keane's Construction and Disjointness by Jon Chaika This thesis is divided into two parts. The first part uses a family of Interval Exchange Transformations constructed by Michael Keane to show that IETs can have some particular behavior including: 1. IETs can be topologically mixing. 2. A minimal IET can have an ergodic measure with Hausdorff dimension a for any a € [0,1]. 3. The complement of the generic points for Lebesgue measure in a minimal nonuniquely ergodic IET can have Hausdorff dimension 0. Note that this is a dense G& set. The second part shows that almost every pair of IETs are different. In particular, the product of almost every pair of IETs is uniquely ergodic. In proving this we show that any sequence of natural numbers of density 1 contains a rigidity sequence for almost every IET, strengthening a result of Veech.
Consumption of cosmetic products by the French population. First part: frequency data.

The aim of this study was to assess the percentage of users, the frequency of use and the number of cosmetic products consumed at home by the French population. The evaluation was performed for adult, child and baby consumers. Pregnant women were also taken into account in this work. All in all, 141 products cosmetics including general hygiene, skin care, hair care, hair styling, make-up, fragrances, solar, shaving and depilatory products were studied. The strengths of the study were the separation of data by sex and by age groups, the consideration of a priori at risk subpopulations and the consideration of a large number of cosmetic products. These current consumption data could be useful for safety assessors and for safety agencies in order to protect the general population and these at risk subpopulations.
Statistical Validation of a Web-Based GIS Application and Its Applicability to Cardiovascular-Related Studies

PURPOSE
There is abundant evidence that neighborhood characteristics are significantly linked to the health of the inhabitants of a given space within a given time frame. This study is to statistically validate a web-based GIS application designed to support cardiovascular-related research developed by the NIH funded Research Centers in Minority Institutions (RCMI) Translational Research Network (RTRN) Data Coordinating Center (DCC) and discuss its applicability to cardiovascular studies.


METHODS
Geo-referencing, geocoding and geospatial analyses were conducted for 500 randomly selected home addresses in a U.S. southeastern Metropolitan area. The correlation coefficient, factor analysis and Cronbach's alpha (α) were estimated to quantify measures of the internal consistency, reliability and construct/criterion/discriminant validity of the cardiovascular-related geospatial variables (walk score, number of hospitals, fast food restaurants, parks and sidewalks).


RESULTS
Cronbach's α for CVD GEOSPATIAL variables was 95.5%, implying successful internal consistency. Walk scores were significantly correlated with number of hospitals (r = 0.715; p < 0.0001), fast food restaurants (r = 0.729; p < 0.0001), parks (r = 0.773; p < 0.0001) and sidewalks (r = 0.648; p < 0.0001) within a mile from homes. It was also significantly associated with diversity index (r = 0.138, p = 0.0023), median household incomes (r = -0.181; p < 0.0001), and owner occupied rates (r = -0.440; p < 0.0001). However, its non-significant correlation was found with median age, vulnerability, unemployment rate, labor force, and population growth rate.


CONCLUSION
Our data demonstrates that geospatial data generated by the web-based application were internally consistent and demonstrated satisfactory validity. Therefore, the GIS application may be useful to apply to cardiovascular-related studies aimed to investigate potential impact of geospatial factors on diseases and/or the long-term effect of clinical trials.