LLukas22/scidocs huggingface dataset:
Electroacupuncture inhibits chronification of the acute pain of knee osteoarthritis: study protocol for a randomized controlled trial

BACKGROUND
Previous studies have shown that electroacupuncture (EA) has a significant effect on acute pain, but it has not solved the clinical problem of the chronification of acute pain. Diffuse noxious inhibitory controls (DNIC) function as a reliable indicator to predict the risk of chronic pain events. DNIC function in knee osteoarthritis (KOA) patients has been demonstrated to gradually decrease during the development of chronic pain. The purpose of this study is to conduct a randomized, controlled clinical trial to determine if EA can repair impaired DNIC function and thus prevent chronification of the acute pain of KOA.


METHODS/DESIGN
This is a multicenter, single blind, randomized, controlled, three-arm, large-scale clinical trial. A total of 450 KOA patients will be randomly assigned to three groups. The strong EA group will receive EA with high-intensity current (2 mA < current < 5 mA) at the ipsilateral 'Neixiyan' (EX-LE5), 'Dubi'(ST35), 'Liangqiu'(ST34) and 'Xuehai' (SP10). The weak EA group will receive EA with low-intensity current (0 mA < current < 0.5 mA) on the same acupoints. The sham EA group will receive EA with low-intensity current (0 mA < current < 0.5 mA) with fine needles inserted superficially into the sites 2 cm lateral to the above acupoints. The patients will be treated with EA once a day, 30 minutes per session, in 5 sessions per week, for 2 weeks. In order to determine the best stage of KOA for effective EA intervention, patients within the treatment groups also will be divided into four stages. The primary outcomes are Visual Analog Scale (VAS), DNIC function and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Clinical assessments will be evaluated at baseline (before treatment) and after 5 to 10 sessions of treatment.


DISCUSSION
This trial will be helpful in identifying whether strong EA is more effective than weak EA in reversing chronification of acute pain through repairing the impaired DNIC function and in screening for the best stage of KOA for effective EA intervention.


TRIAL REGISTRATION
Chinese Clinical Trial Registry Number: ChiCTR-ICR-14005411. The date of registration is 31 October 2014.
Serotonergic nerve fibers in l-DOPA-derived dopamine release and dyskinesia

The 5-HT (5-hydroxytryptamine) system has been assigned a key role in the development of 3,4-dihydroxyphenyl-l-alanine (l-DOPA)-induced dyskinesia, mainly due to 5-HT neuronal ability to decarboxylate l-DOPA into dopamine. Nevertheless, knowledge of l-DOPA-induced events that could lead to development of dyskinesias are limited and therefore the present work has evaluated (i) the role of the 5-HT system in l-DOPA-derived dopamine synthesis when dopamine neurons are present, (ii) l-DOPA-induced effects on striatal dopamine release and clearance, and on 5-HT nerve fiber density, and (iii) the behavioral outcome of altered 5-HT transmission in dyskinetic rats. Chronoamperometric recordings demonstrated attenuated striatal l-DOPA-derived dopamine release (∼30%) upon removal of 5-HT nerve fibers in intact animals. Interestingly, four weeks of daily l-DOPA treatment yielded similar-sized dopamine peak amplitudes in intact animals as found after a 5-HT-lesion. Moreover, chronic l-DOPA exposure attenuated striatal 5-HT nerve fiber density in the absence of dopamine nerve terminals. Furthermore, fluoxetine-induced altered 5-HT transmission blocked dyskinetic behavior via action on 5-HT1A receptors. Taken together, the results indicate a central role for the 5-HT system in l-DOPA-derived dopamine synthesis and in dyskinesia, and therefore potential l-DOPA-induced deterioration of 5-HT function might reduce l-DOPA efficacy as well as promote the upcoming of motor side effects.
Endoscopic surgery for malignant tumors of the sinonasal tract and adjacent skull base: a 10-year experience.

BACKGROUND
The increasing expertise in the field of transnasal endoscopic surgery recently has expanded its indications to include the management of sinonasal malignancies. We report our experience with the endoscopic management of nasoethmoidal malignancies possibly involving the adjacent skull base.


METHODS
A retrospective analysis was performed of patients treated by an exclusive endoscopic approach (EEA) or a cranioendoscopic approach (CEA) from 1996 to 2006 managed by two surgical teams at the Departments of Otorhinolaryngology of the University of Brescia, and the University of Pavia/Insubria-Varese, Italy.


RESULTS
One-hundred eighty-four patients were considered eligible for the present analysis. An EEA was performed in 134 patients and the remaining 50 patients underwent the CEA. The most frequent histotypes encountered were adenocarcinoma (37%), squamous cell carcinoma (13.6%), olfactory neuroblastoma (12%), mucosal melanoma (9.2%), and adenoid cystic carcinoma (7.1%). Overall, 86 (46.7%) patients received some form of adjuvant treatment. The patients were followed up for a mean of 34.1 months (range, 2-123 months). The 5-year disease-specific survival was 91.4 +/- 3.9% and 58.8 +/- 8.6% (p = 0.0004) for the EEA and CEA group, respectively.


CONCLUSION
To the best of our knowledge, this is the largest series reported to date of malignant tumors of the sinonasal tract and adjacent skull base treated with pure endoscopic or cranioendoscopic techniques. A 5-year disease-specific survival of 91.4% and 58.8% for the EEA and the CEA groups, respectively, seem to indicate that endoscopic surgery, when properly planned and in expert hands, may be a valid alternative to standard surgical approaches for the management of malignancies of the sinonasal tract.
Green Reconfigurable Radio Systems

The wireless standards scene and its evolution strengthens the need for functional flexibility in future radios. Multimode terminals supporting an increasingly large variety of standards (cellular, WLANs, WMANs, WPANs) are subject to a cost increase that is addressed by more flexible radio interfaces. Energy efficiency, however, is the main obstacle to successfully deploying such reconfigurable radios. To address this, it is essential to design energy-scalable SDRs, both for the radio front-end and the digital baseband platform. Complementing this, an essential ingredient is an intelligent controller that optimally exploits this scalability and the run-time dynamics to translate potential energy scalability to actual low-power operation. To realize this goal, an energy-aware cross-layer radio management framework is introduced. It was instantiated in different case studies, showing the applicability of this approach in realistic setups. Results have shown that substantial gains can be achieved through effective cross-layer optimization and problem partitioning. Next, it was shown that SDRs will play a crucial role in enabling CRs, which will enable saving on both the scarce radio spectrum and battery lifetime. A key building block for the design of such CRs, i.e., the appropriate control intelligence to make the SDR platform cognitive, can be derived by incrementally building on the proposed framework. As a result, green (or environment friendly) reconfigurable radio systems will emerge, which offer a wide variety and ubiquitous availability of wireless services, while overcoming energy and spectrum scarcity
Physical impairment index: reliability, validity, and responsiveness in patients with acute low back pain.

STUDY DESIGN
Cohort study of patients with acute low back pain undergoing physical therapy.


OBJECTIVES
Examine the reliability and validity of the Physical Impairment Index in a group of patients with acute low back pain and determine the responsiveness and minimum detectable change of the index and its component tests.


SUMMARY OF THE BACKGROUND DATA
The Physical Impairment Index was originally described as a reliable and valid means of assessing physical impairment in patients with low back pain. The psychometric properties of the index have not been reported in patients with acute low back pain, nor has its responsiveness been examined.


METHODS
Seventy-eight patients with acute (<3 weeks duration) low back pain participating in a clinical trial were assessed at baseline and after 4 weeks. Interrater reliability of the index was examined in a subgroup of 20 patients. Validity was examined through correlations with concurrent measures of pain, disability, and psychosocial variables. Changes in the index over 4 weeks were used to assess responsiveness and minimum detectable change.


RESULTS
Interrater reliability of the index was high (intraclass correlation coefficient = 0.89), and its validity was generally supported by the pattern of correlations. The index was more responsive to change than any of its component tests but was less responsive than the Oswestry disability score. The minimum detectable change on the index was approximately 1 point.


CONCLUSIONS
The Physical Impairment Index appears to be a reliable and valid measure of physical impairment for patients with acute low back pain and may be useful as an adjunct outcome measure for studies involving these patients. Further research on patients with chronic pain is needed before it can be advocated for outcomes research with this population.
DIVILAR: diversifying intermediate language for anti-repackaging on android platform

App repackaging remains a serious threat to the emerging mobile app ecosystem. Previous solutions have mostly focused on the postmortem detection of repackaged apps by measuring similarity among apps. In this paper, we propose DIVILAR, a virtualization-based protection scheme to enable self-defense of Android apps against app repackaging. Specifically, it re-encodes an Android app in a diversified virtual instruction set and uses a specialized execute engine for these virtual instructions to run the protected app. However, this extra layer of execution may cause significant performance overhead, rendering the solution unacceptable for daily use. To address this challenge, we leverage a light-weight hooking mechanism to hook into Dalvik VM, the execution engine for Dalvik bytecode, and piggy-back the decoding of virtual instructions to that of Dalvik bytecode. By compositing virtual and Dalvik instruction execution, we can effectively eliminate this extra layer of execution and significantly reduce the performance overhead. We have implemented a prototype of DIVILAR. Our evaluation shows that DIVILAR is resilient against existing static and dynamic analysis, including these specific to VM-based protection. Further performance evaluation demonstrates its efficiency for daily use (an average of 16.2 and 8.9 increase to the start time and run time, respectively).
The Effect of Exogenous Glucose-Dependent Insulinotropic Polypeptide in Combination With Glucagon-Like Peptide-1 on Glycemia in the Critically Ill

OBJECTIVE
Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) have additive insulinotropic effects when coadministered in health. We aimed to determine whether GIP confers additional glucose lowering to that of GLP-1 in the critically ill.


RESEARCH DESIGN AND METHODS
Twenty mechanically ventilated critically ill patients without known diabetes were studied in a prospective, randomized, double-blind, crossover fashion on 2 consecutive days. Between T0 and T420 minutes, GLP-1 (1.2 pmol/kg·min(-1)) was infused intravenously with either GIP (2 pmol/kg·min(-1)) or 0.9% saline. Between T60 and T420 minutes, nutrient liquid was infused into the small intestine at 1.5 kcal/min.


RESULTS
Adding GIP did not alter blood glucose or insulin responses to small intestinal nutrient. GIP increased glucagon concentrations slightly before nutrient delivery (P=0.03), but not thereafter.


CONCLUSIONS
The addition of GIP to GLP-1 does not result in additional glucose-lowering or insulinotropic effects in critically ill patients with acute-onset hyperglycemia.
Matching Handwritten Document Images

Given a pair of handwritten documents written by different individuals, compute a document similarity score irrespective of (i) handwritten styles, (ii) word forms, word ordering and word overflow. • IIIT-HWS: Introducing a large scale synthetic corpus of handwritten word images for enabling deep architectures. • HWNet: A deep CNN architecture for state of the art handwritten word spotting in multi-writer scenarios. • MODS: Measure of document similarity score irrespective of word forms, ordering and paraphrasing of the content. • Applications in Educational Scenario: Comparing handwritten assignments, searching through instructional videos. 2. Contributions 3. Challenges
Cervical cancer screening in the urgent care setting

OBJECTIVE: To determine the feasibility of cervical cancer screening in an urgent care clinic. DESIGN: Prospective randomized trial. SETTING: Public teaching hospital. PATIENTS: Women presenting to the urgent care clinic whose evaluation necessitated a pelvic examination were eligible for participation. Women who had a hysterectomy, had a documented Pap test at our institution in the past year, did not speak English or Spanish, or had significant vaginal bleeding were excluded. Women presenting to the gynecology clinic for a scheduled Pap test were used as a comparison group for rates of follow-up, Pap smear adequacy, and Pap smear abnormalities. INTERVENTIONS: Women randomized to the intervention group had a Pap test performed as part of their pelvic examination, while women in the usual care group were encouraged to schedule an appointment in the gynecology clinic at a later date. The women in the two groups completed identical questionnaires regarding cervical cancer risk factors and demographic information. MEASUREMENTS AND MAIN RESULTS: Ninety-four (84.7%) of 111 women in the intervention group received a Pap test, as compared with 25 (29%) of 86 in the usual care group (P<.01). However, only 5 (24%) of 21 women with abnormal Pap smears in the intervention group received follow-up compared with 6 (60%) of 10 women seen during the same time period in the gynecology clinic for self-referred, routine annual examinations (P=.11). Pap smears obtained in the urgent care clinic were similar to those in the gynecology clinic with regard to abnormality rate (22.3% vs 20%; P=.75, respectively) and specimen adequacy (67% vs 72%; P=.54, respectively). CONCLUSIONS: Urgent care clinic visits can be used as opportunities to perform Pap test screening in women who are unlikely to adhere to cervical cancer screening recommendations. However, to accure the full potential benefit from this intervention, an improved process to ensure patient follow-up must be developed.
Dot-product engine for neuromorphic computing: Programming 1T1M crossbar to accelerate matrix-vector multiplication

Vector-matrix multiplication dominates the computation time and energy for many workloads, particularly neural network algorithms and linear transforms (e.g, the Discrete Fourier Transform). Utilizing the natural current accumulation feature of memristor crossbar, we developed the Dot-Product Engine (DPE) as a high density, high power efficiency accelerator for approximate matrix-vector multiplication. We firstly invented a conversion algorithm to map arbitrary matrix values appropriately to memristor conductances in a realistic crossbar array, accounting for device physics and circuit issues to reduce computational errors. The accurate device resistance programming in large arrays is enabled by close-loop pulse tuning and access transistors. To validate our approach, we simulated and benchmarked one of the state-of-the-art neural networks for pattern recognition on the DPEs. The result shows no accuracy degradation compared to software approach (99 % pattern recognition accuracy for MNIST data set) with only 4 Bit DAC/ADC requirement, while the DPE can achieve a speed-efficiency product of 1,000× to 10,000× compared to a custom digital ASIC.
Robust GMM Based Gender Classification using Pitch and RASTA-PLP Parameters of Speech

A novel gender classification system has been proposed based on Gaussian mixture models, which apply the combined parameters of pitch and 10th order relative spectral perceptual linear predictive coefficients to model the characteristics of male and female speech. The performances of gender classification system have been evaluated on the conditions of clean speech, noisy speech and multi-language. The simulations show that the performance of the proposed gender classifier is excellent; it is very robust for noise and completely independent of languages; the classification accuracy is as high as above 98% for all clean speech and remains 95% for most noisy speech, even the SNR of speech is degraded to OdB
A New Proposed Dynamic Quantum with Re-Adjusted Round Robin Scheduling Algorithm and Its Performance Analysis

Scheduling is the central concept used frequently in Operating System. It helps in choosing the processes for execution. Round Robin (RR) is one of the most widely used CPU scheduling algorithm. But, its performance degrades with respect to context switching, which is an overhead and it occurs during each scheduling. Overall performance of the system depends on choice of an optimal time quantum, so that context switching can be reduced. In this paper, we have proposed a new variant of RR scheduling algorithm, known as Dynamic Quantum with Re-adjusted Round Robin (DQRRR) algorithm. We have experimentally shown that performance of DQRRR is better than RR by reducing number of context switching, average waiting time and average turnaround time.
Internet addiction in students: Prevalence and risk factors

The last decade has witnessed a large increase in research on the newly emerging mental health problem of Internet addiction. Rather than looking at Internet addiction per se, this study focused on particular activities on the Internet that might be potentially addictive and linked them to personality traits that might predispose individuals to Internet addiction. The aims of this study were (i) to assess the prevalence of clinically significant levels of Internet addiction, and to (ii) discern the interplay between personality traits and specific Internet uses in increasing the risk for Internet addiction. This cross-sectional online survey used data from 2,257 students of an English university. Results indicated that 3.2% of the students were classified as being addicted to the Internet. The included personality traits and uses of online activities explained 21.5% of the variance in Internet addiction. A combination of online shopping and neuroticism decreased the risk for Internet addiction, whereas a combination of online gaming and openness to experience increased it. In addition to this, frequent usage of online shopping and social online activities, high neuroticism and low agreeableness significantly increased the chances of being addicted to the Internet. Findings and their implications
Acid-Suppressive Therapy With Esomeprazole for Relief of Unexplained Chest Pain in Primary Care: A Randomized, Double-Blind, Placebo-Controlled Trial

OBJECTIVES:High-quality data regarding the efficacy of acid-suppressive treatment for unexplained chest pain are lacking. The aim of this study was to evaluate the efficacy of esomeprazole in primary-care treatment of patients with unexplained chest pain stratified for frequency of reflux/regurgitation symptoms.METHODS:Patients with a ≥2-week history of unexplained chest pain (unrelated to gastroesophageal reflux) who had at least moderate pain on ≥2 of the last 7 days were stratified by heartburn/regurgitation frequency (≤1 day/week (stratum 1) vs. ≥2 days/week (stratum 2)) and randomized to 4 weeks of double-blind treatment with twice-daily esomeprazole 40 mg or placebo. Chest pain relief during the last 7 days of treatment (≤1 day with minimal symptoms assessed daily using a 7-point scale) was analyzed by stratum in keeping with the predetermined analysis plan.RESULTS:Overall, 599 patients (esomeprazole: 297, placebo: 302) were randomized. In stratum 1, more esomeprazole than placebo recipients achieved chest pain relief (38.7% vs. 25.5%; P=0.018); no between-treatment difference was observed in stratum 2 (27.2% vs. 24.2%; P=0.54). However, esomeprazole was superior to placebo in a post-hoc analysis of the whole study population (combined strata; 33.1% vs. 24.9%; P=0.035).CONCLUSIONS:A 4-week course of high-dose esomeprazole provided statistically significant relief of unexplained chest pain in primary-care patients who experienced infrequent or no heartburn/regurgitation, but there was no such significant reduction in patients with more frequent reflux symptoms.
Impairment of olfaction and mucociliary clearance after expanded endonasal approach using vascularized septal flap reconstruction for skull base tumors.

BACKGROUND
Endoscopic skull base surgery is now the preferred treatment option to remove skull base tumors.


OBJECTIVE
To evaluate the patient's sense of smell and mucociliary clearance time (MCT) after skull base surgery.


METHODS
Patients with pituitary adenoma underwent a transnasal transsphenoidal endoscopic approach (TTEA group, n = 36), whereas patients with other benign parasellar tumors underwent an expanded endonasal approach (EEA group, n = 14) with a vascularized septal flap. Assessment of symptoms (Visual Analogue Scale), olfactometry (Barcelona Smell Test, BAST-24), and MCT (saccharin test) were performed before and 3 months after surgery.


RESULTS
Before surgery, patients reported poorer BAST-24 scores on detection, identification, and forced choice than the healthy population, but both study groups had similar sinonasal symptoms, BAST-24, and MCT scores. After surgery, no changes in symptom scores (Visual Analogue Scale) were observed except for the loss of smell (26.7 ± 30.5 mm, P < .05) and posterior nasal discharge (29.7 ± 30.3 mm, P < .05) compared with baseline (5.2 ± 11.3, 19.1 ± 25.3, respectively). EEA patients reported higher loss of smell and posterior nasal discharge compared with TTEA. TTEA and EEA groups had similar scores on postoperative BAST-24. After surgery, however, patients showed prolonged saccharin test (15.6 ± 10.8 min, P < .05) compared with baseline (8.4 ± 4.4 min). In addition, EEA patients reported longer MCT than TTEA patients.


CONCLUSION
EEA but not TTEA has a short-term (3 months) negative impact on patient's olfaction and mucociliary clearance. Patients should be informed about smell loss as a consequence of skull base surgery to prevent legal claims. Likewise, further research and some modifications on reconstruction flaps are encouraged to avoid damaging the olfactory neuroepithelium.
Evaluation of neutrinos mass based on ENU model

Based on principles of the Expansive Nondecelerative Universe model that enables to quantify and localize the gravitational energy density, and stemming from the see-saw mechanism, the mass of electron, muon and tau neutrinos are determined in an independent way.
New Frontiers in Formal Methods: Learning, Cyber-Physical Systems, Education, and Beyond

We survey promising directions for research in the area of formal methods and its applications, including fundamental questions about the combination of formal methods and machine learning, and applications to cyberphysical systems and education.