LLukas22/scidocs huggingface dataset:
Ovarectomy despite Negative Imaging in Anti-NMDA Receptor Encephalitis: Effective Even Late

Anti-NMDA receptor (NMDAR) encephalitis is an autoimmune antibody-mediated neuropsychiatric disorder. The disorder is known to be associated with ovarian teratoma and predominantly affects young women. Here, we report the case of a 34-year-old woman with anti-NMDAR encephalitis, in which detailed investigations gave no specific hint for an ovarian teratoma. Despite this, and due to a continuous severe clinical syndrome, an ovarectomy was performed and histological examination revealed an occult teratoma. The ovarectomy led to a remarkable improvement even with a long term intensive care treatment for 11 months. The most important lesson to be learned from this instructive case is that even though none of the investigations was indicative for an ovarian teratoma, including an explorative laparoscopy with biopsy, there still may be an occult ovarian teratoma. This shows that tumour search and diagnosis are extremely important in patients presenting with anti-NMDAR encephalitis, and a laparotomy and ovarectomy is justified. Furthermore, removal of the teratoma even 11 months after a very severe course is still therapeutically effective.
Something’s missing here: a look at the quality of rheumatology referral letters

A convincing body of evidence points to an early window of opportunity for the treatment of rheumatoid arthritis. However, data indicate that in many cases, this window of opportunity is missed. Once a patient does present to their primary care provider, important additional delays in rheumatology assessment can occur. To report the results of our study assessing referral letters to rheumatologists, we examined referral letters received over a one-year period by one full-time rheumatologist practicing at a tertiary-care center. We found only a small percentage of referral letters made mention of the pattern of joint involvement. Just 17% of consults indicated symptom duration. Only 2% mentioned any circadian rhythm of symptoms (such as morning stiffness), and only 6% provided information about functional status. Almost two-thirds (62%) of consults specified only ‘joint pain’ in the referral letter. We provide objective evidence that referral letters sent to rheumatologists are often lacking in key elements of the medical history. This lack of information means that appropriate triage of referrals by rheumatologists is very difficult. As a response to this, we have developed, with family physicians and rheumatologists, a standardized referral template which is being pilot-tested. Our ultimate goal is to improve wait times for patients with urgent conditions such as inflammatory arthritis.
Evaluating the Usability of Optimizing Text-based CAPTCHA Generation

A CAPTCHA is a test that can, automatically, tell human and computer programs apart. It is a mechanism widely used nowadays for protecting web applications, interfaces, and services from malicious users and automated spammers. Usability and robustness are two fundamental aspects with CAPTCHA, where the usability aspect is the ease with which humans pass its challenges, while the robustness is the strength of its segmentation-resistance mechanism. The collapsing mechanism, which is removing the space between characters to prevent segmentation, has been shown to be reasonably resistant to known attacks. On the other hand, this mechanism drops considerably the human-solvability of text-based CAPTCHAs. Accordingly, an optimizer has previously been proposed that automatically enhances the usability of a CAPTCHA generation without sacrificing its robustness level. However, this optimizer has not yet been evaluated in terms of improving the usability. This paper, therefore, evaluates the usability of this optimizer by conducting an experimental study. The results of this evaluation showed that a statistically significant enhancement is found in the usability of text-based CAPTCHA generation. Keywords—text-based CAPTCHA; usability; security; optimization; experimentation; evaluation
Relation-algebraic computation of fixed points with applications

We use relational algebra for describing sets and sets of sets and for computing all fixed points of certain functions on powersets. The method is illustrated by some examples from different problem domains, and results of our practical experiments with the RelView system are reported.
Subverting the market to help other consumers: The ‘la repasse’ phenomenon

This paper aims to broaden our perspective on Consumer-to-Consumer (C-to-C) interactions. Recent studies on consumption have striven to shed light on the grey zone between market economies and moral economies. Our research goes one step further by focusing on C-to-C helping behaviours such as passing on tickets in public places (on the underground, in car parks, during city package tours, etc.). The hermeneutic analysis of these fraudulent practices shows that consumers undertake these microsubversions of the marketplace for the sake of citizenship. They act as contemporary Robin Hoods who turn market materials into flash token gifts for other consumers. In doing so, they daily reshape the boundaries of market/moral economies. Copyright © 2015 John Wiley & Sons, Ltd.
UvA-DARE ( Digital Academic Repository ) Regional and seasonal flight speeds of soaring migrants and the role of weather at hourly and daily scales

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Edge Computing for the Internet of Things: A Case Study

The amount of data generated by sensors, actuators, and other devices in the Internet of Things (IoT) has substantially increased in the last few years. IoT data are currently processed in the cloud, mostly through computing resources located in distant data centers. As a consequence, network bandwidth and communication latency become serious bottlenecks. This paper advocates edge computing for emerging IoT applications that leverage sensor streams to augment interactive applications. First, we classify and survey current edge computing architectures and platforms, then describe key IoT application scenarios that benefit from edge computing. Second, we carry out an experimental evaluation of edge computing and its enabling technologies in a selected use case represented by mobile gaming. To this end, we consider a resource-intensive 3-D application as a paradigmatic example and evaluate the response delay in different deployment scenarios. Our experimental results show that edge computing is necessary to meet the latency requirements of applications involving virtual and augmented reality. We conclude by discussing what can be achieved with current edge computing platforms and how emerging technologies will impact on the deployment of future IoT applications.
Diagnostic values of positron emission tomography versus triple-phase bone scan in hip arthroplasty loosening

The most frequent complications of total hip arthroplasty are septic and aseptic wear-induced loosening. A reliable differentiation between septic and aseptic loosening with current diagnostic tools is not possible. Therefore, we examined the diagnostic valency of positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) in cases of septic or aseptic hip arthroplasty loosening compared with conventional triple-phase bone scan (TPBS). Fifty patients with 70 total hip replacements (symptomatic n=50, asymptomatic n=20) were examined by means of FDG-PET and TPBS to detect septic and aseptic loosening and differentiate between the two. A differentiated algorithm subdivided into categories I–V was developed for FDG-PET. Additionally, standardized uptake values (SUV) were calculated from the lesion with the highest FDG uptake. Interpretations of the TPBS were done according to the criteria described by Wilson. The final diagnosis was based on operative findings including microbiological and histological examinations (n=50), while the remaining asymptomatic arthroplasties (n=20) were integrated into a clinical follow-up (≥9 months). Sensitivity/specificity of FDG-PET was 91%/92% (accuracy 91%) compared with 78%/70% (accuracy 74%) for TPBS. A high correlation could be proved between FDG-PET investigation and operative histopathological findings (rSpear≥0.9). No significant differences were found regarding cemented and uncemented implanted hip arthroplasties (p≥0.05). Calculation of the SUV turned out to be inappropriate as a sole criterion for image interpretation. FDG-PET is a promising, highly accurate examination method to detect polyethylene and metal wear-induced chronic inflammation followed by periprosthetic osteolysis. In addition, FDG-PET has a significantly higher sensitivity and specificity than TPBS for differentiating between aseptic loosening and infection.
Early organizations of biomedical engineering in the US

The author provides some facts about the early history of the Institute for Radio Engineers Professional Group on Medical Electronics, which later became today's IEEE Engineering in Medicine and Biology Society, to supplement the information given in a 1959 article by L.H. Montgomery, which is reprinted in ibid., vol.12, no.3, p.30-3 (1993).<<ETX>>
Faust on Film: A Hegelian Modern Art

The purpose of this paper is to investigate the relationship between German Expressionist film and Hegel’s system of aesthetics. Through an analysis of the aesthetic qualities of Hanns Ewers’ The Student of Prague (1913) and F.W. Murnau’s Faust, I believe we have evidence to believe that the subjectivity that German Expressionist film sought to capture is aligned with the ‘interiority’ that Hegel believes Romantic art expresses. Further, I will consider whether these two films indicate that film as an artistic medium falls within Hegel’s characterization of Modern art. I believe that because both Student of Prague and Faust use elements of Romantic art in an effort to convey the melancholy spirit, and that the melancholy spirit is reflection and product of a uniquely modern Germany, these films indicate that film as a medium fulfill the requirements Hegel sets for Modern art. INDEX WORDS: Hegel, Modern Art, Film, German Expressionism, Student of Prague (1913), Faust (1926), Melancholy FOUST ON FILM: A HEGELIAN MODERN ART
Impact of Sagittal Balance on Clinical Outcomes in Surgically Treated T12 and L1 Burst Fractures: Analysis of Long-Term Outcomes after Posterior-Only and Combined Posteroanterior Treatment

Objective. Long-term radiological and clinical outcome retrospective study of surgical treatment for T12 and L1 burst fractures in perspective of sagittal balance measures. Methods. Patients with age of 16-60 years, complete radiographs, early surgical treatment surgery, and follow-up (F/U) > 18 months were included and strict exclusion criteria applied. Regional and thoracolumbar kyphosis angles (RKA and TLA) were measured preoperatively and at final F/U, as were parameters of the spinopelvic sagittal alignment. Clinical outcomes were assessed using validated measures. Results. 36 patients with age mean age of 39 years and F/U of 69 months were included. 61% of patients were treated with bisegmental posterior instrumentation (POST-I) and 39% with combined posteroanterior instrumented fusion (PA-F). At F/U, several indicators for clinical outcomes showed a significant correlation with radiographic measures in the overall cohort with inferior clinical outcomes corresponding with increasing residual deformity and sagittal malalignment. Statistical analysis failed to reach level of significance for the differences between POST-I and PA-F group at final F/U. Only a strong trend towards better restoration of the thoracolumbar alignment was observed for the PA-F group in terms of the RKA and TLA. Conclusions. Results in a surgically treated cohort of T12 and L1 burst fracture patients indicate that superior clinical outcomes depend on restoration of sagittal alignment.
Workforce management in omnichannel service centers with heterogeneous channel response urgencies

Article history: Received 7 May 2017 Received in revised form 7 September 2017 Accepted 17 October 2017 Available online xxxx Workforce staffing and assignment decisions are of critical importance for meeting the challenge of minimizing operational costs while providing satisfactory customer service. These decisions are particularly challenging for omnichannel service centers, where customers can request services via different communication channels (e.g., phone, e-mail, live-chat, social media) that have different service quality and response requirements. We present a formulation of the omnichannel workforce management problem that accounts for variations in response urgencies of different channels as well as diminishing agent performances due to channel switching. We develop an algorithm that efficiently provides solutions for this problem and determines the number and channel allocation of service agentswithin the service center. Through numerical experiments, we study the performance of the algorithm among various service center configurations with equal cost characteristics. The results indicate that the proposed algorithm can identify service center structures that outperform many alternative structures, including those commonly-adopted in the real-world. © 2017 Published by Elsevier B.V.
Differential impact of methylphenidate and atomoxetine on sustained attention in youth with attention-deficit/hyperactivity disorder.

BACKGROUND
This study examined the effects of atomoxetine (ATX) and OROS methylphenidate (MPH) on laboratory measures of inhibitory control and attention in youth with attention-deficit/hyperactivity disorder (ADHD). It was hypothesized that performance would be improved by both treatments, but response profiles would differ because the medications work via different mechanisms.


METHODS
One hundred and two youth (77 male; mean age = 10.5 ± 2.7 years) with ADHD received ATX (1.4 ± 0.5 mg/kg) and MPH (52.4 ± 16.6 mg) in a randomized, double-blind, crossover design. Medication was titrated in 4-6-week blocks separated by a 2-week placebo washout. Inhibitory control and attention measures were obtained at baseline, following washout, and at the end of each treatment using Conners' Continuous Performance Test II (CPT-II), which provided age-adjusted T-scores for reaction time (RT), reaction time variability (RT variability), and errors. Repeated-measures analyses of variance were performed, with Time (premedication, postmedication) and Treatment type (ATX, MPH) entered as within-subject factors. Data from the two treatment blocks were checked for order effects and combined if order effects were not present.


CLINICAL TRIAL REGISTRATION
Clinicaltrials.gov: NCT00183391.


RESULTS
Main effects for Time on RT (p = .03), RTSD (p = .001), and omission errors (p = .01) were significant. A significant Drug × Time interaction indicated that MPH improved RT, RTSD, and omission errors more than ATX (p < .05). Changes in performance with treatment did not correlate with changes in ADHD symptoms.


CONCLUSIONS
MPH has greater effects than ATX on CPT measures of sustained attention in youth with ADHD. However, the dissociation of cognitive and behavioral change with treatment indicates that CPT measures cannot be considered proxies for symptomatic improvement. Further research on the dissociation of cognitive and behavioral endpoints for ADHD is indicated.
Supporting Composite Smart Home Services with Semantic Fault Management

The proliferation of smart home technologies providing home users with digital services presents an interoperability problem. This paper asserts that the value of these services can be greatly extended by enabling technology-neutral compositions of these home services, and furthermore that the reliability of such composite services will be of paramount importance to ensuring widespread deployment. Therefore fault management capabilities must accompany the composition capabilities in order to increase the robustness and reliability of such services. This paper proposes a web services-based abstraction layer for home area network service composition and a semantically informed fault management system for composed services, which can assist in diagnosis and correction of problems with composite services in smart homes of the future. Prototyping work and use cases are also described and initial metrics are presented that investigate the overhead of introducing the technology neutral abstraction layer.
Advancement of global health: key messages from the Disease Control Priorities Project

The Disease Control Priorities Project (DCPP), a joint project of the Fogarty International Center of the US National Institutes of Health, the WHO, and The World Bank, was launched in 2001 to identify policy changes and intervention strategies for the health problems of low-income and middle-income countries. Nearly 500 experts worldwide compiled and reviewed the scientific research on a broad range of diseases and conditions, the results of which are published this week. A major product of DCPP, Disease Control Priorities in Developing Countries, 2nd edition (DCP2), focuses on the assessment of the cost-effectiveness of health-improving strategies (or interventions) for the conditions responsible for the greatest burden of disease. DCP2 also examines crosscutting issues crucial to the delivery of quality health services, including the organisation, financial support, and capacity of health systems. Here, we summarise the key messages of the project.
An analytical review of vasculobiliary injury in laparoscopic and open cholecystectomy.

OBJECTIVES
Biliary injuries are frequently accompanied by vascular injuries, which may worsen the bile duct injury and cause liver ischemia. We performed an analytical review with the aim of defining vasculobiliary injury and setting out the important issues in this area.


METHODS
A literature search of relevant terms was performed using OvidSP. Bibliographies of papers were also searched to obtain older literature.


RESULTS
 Vasculobiliary injury was defined as: an injury to both a bile duct and a hepatic artery and/or portal vein; the bile duct injury may be caused by operative trauma, be ischaemic in origin or both, and may or may not be accompanied by various degrees of hepatic ischaemia. Right hepatic artery (RHA) vasculobiliary injury (VBI) is the most common variant. Injury to the RHA likely extends the biliary injury to a higher level than the gross observed mechanical injury. VBI results in slow hepatic infarction in about 10% of patients. Repair of the artery is rarely possible and the overall benefit unclear. Injuries involving the portal vein or common or proper hepatic arteries are much less common, but have more serious effects including rapid infarction of the liver.


CONCLUSIONS
Routine arteriography is recommended in patients with a biliary injury if early repair is contemplated. Consideration should be given to delaying repair of a biliary injury in patients with occlusion of the RHA. Patients with injuries to the portal vein or proper or common hepatic should be emergently referred to tertiary care centers.
High dynamic range imaging pipeline on the GPU

Use of high dynamic range (HDR) images and video in image processing and computer graphics applications is rapidly gaining popularity. However, creating and displaying high resolution HDR content on CPUs is a time consuming task. Although some previous work focused on real-time tone mapping, implementation of a full HDR imaging (HDRI) pipeline on the GPU has not been detailed. In this article we aim to fill this gap by providing a detailed description of how the HDRI pipeline, from HDR image assembly to tone mapping, can be implemented exclusively on the GPU. We also explain the trade-offs that need to be made for improving efficiency and show timing comparisons for CPU versus GPU implementations of the HDRI pipeline.
Clinical profile and significance of delayed enhancement in hypertrophic cardiomyopathy.

BACKGROUND
Contrast-enhanced cardiovascular magnetic resonance with delayed enhancement (DE) can provide in vivo assessment of myocardial fibrosis. However, the clinical significance of DE in hypertrophic cardiomyopathy (HCM) remains unresolved.


METHODS AND RESULTS
Cine and cardiovascular magnetic resonance with DE were performed in 202 HCM patients (mean age, 42+/-17 years; 71% male), DE was compared with clinical and demographic variables, and patients were followed up for 681+/-249 days for adverse disease events. DE was identified in 111 (55%) HCM patients, occupying 9%+/-11% of left ventricular myocardial volume, including >25% DE in 10% of patients. The presence of DE was related to occurrence of heart failure symptoms (P=0.05) and left ventricular systolic dysfunction (P=0.001). DE was present in all patients with ejection fraction < or =50% but also in 53% (102/192) of patients with preserved ejection fraction (P<0.001); %DE was both inversely related to (r=-0.3; P<0.001) and an independent predictor of ejection fraction (r=-0.4; P<0.001). DE (7%+/-7% of left ventricle) was present in 54 patients who were asymptomatic (and with normal ejection fraction). Over the follow-up period, the annualized adverse cardiovascular event rate in patients with DE exceeded that in patients without DE but did not achieve statistical significance (5.5% versus 3.3%; P=0.5).


CONCLUSIONS
In a large HCM cohort, DE was an independent predictor of systolic dysfunction but with only a modest relationship to heart failure symptoms. These data suggest an important role for myocardial fibrosis in the clinical course of HCM patients but are not sufficient at this time to consider DE as an independent risk factor for adverse prognosis.
Small sample performance of bias-corrected sandwich estimators for cluster-randomized trials with binary outcomes.

The sandwich estimator in generalized estimating equations (GEE) approach underestimates the true variance in small samples and consequently results in inflated type I error rates in hypothesis testing. This fact limits the application of the GEE in cluster-randomized trials (CRTs) with few clusters. Under various CRT scenarios with correlated binary outcomes, we evaluate the small sample properties of the GEE Wald tests using bias-corrected sandwich estimators. Our results suggest that the GEE Wald z-test should be avoided in the analyses of CRTs with few clusters even when bias-corrected sandwich estimators are used. With t-distribution approximation, the Kauermann and Carroll (KC)-correction can keep the test size to nominal levels even when the number of clusters is as low as 10 and is robust to the moderate variation of the cluster sizes. However, in cases with large variations in cluster sizes, the Fay and Graubard (FG)-correction should be used instead. Furthermore, we derive a formula to calculate the power and minimum total number of clusters one needs using the t-test and KC-correction for the CRTs with binary outcomes. The power levels as predicted by the proposed formula agree well with the empirical powers from the simulations. The proposed methods are illustrated using real CRT data. We conclude that with appropriate control of type I error rates under small sample sizes, we recommend the use of GEE approach in CRTs with binary outcomes because of fewer assumptions and robustness to the misspecification of the covariance structure.