LLukas22/scidocs huggingface dataset:
Long-term prospective assessment of shoulder function after breast reconstruction involving a latissimus dorsi muscle flap transfer and postoperative radiotherapy.

BACKGROUND
Several investigators have evaluated the impaired function of the shoulder after removal of the latissimus dorsi muscle for breast reconstruction. However, a few investigators have studied whether including radiotherapy has a negative effect on functional recovery of the shoulder by a long-term follow-up after surgery. In this study, we compared objective measurements of shoulder function preoperatively and postoperatively for 3 years after latissimus dorsi muscle (LDM) flap transfer and postoperative radiotherapy (PRT).


METHODS
Eighteen patients who underwent unilateral transfer of a pedicled LDM flap and PRT within 2 months of breast-conserving surgery were enrolled in this study. Range of motion (ROM) and muscle strength in exhaustive shoulder movements were measured before surgery, and at 3 and 6 months, and 1 and 3 years.


RESULTS
The results of ROM measurements at 3months postsurgery showed significant decreases in both flexion and abduction by 7.1 and 9.2 % and at 3 years postsurgery by 4.7 and 5.7 %. The muscle strength measurements at 3 months postsurgery showed statistically significant decreases both in adduction and in the 2nd medial rotation by 30.7 and 25.9 % and at 3 years postsurgery by 36.4 and 20.4 %. A significant improvement in these impairments was not observed for 3 years after surgery compared with that at 3 months after surgery.


CONCLUSION
A combination of the LDM flap procedure and PRT could be associated with a higher incidence of tissue adhesions in both flexion and abduction and muscle deficit both in adduction and in the 2nd medial rotation.
Analysis of emission data from global commercial aviation: 2004 and 2006

The global commercial aircraft fleet in 2006 flew 31.26 million flights, burned 188.20 million metric tons of fuel, and covered 38.68 billion kilometers. This activity emitted substantial amounts of fossil-fuel combustion products within the upper troposphere and lower stratosphere that affect atmospheric composition and climate. The emissions products, such as carbon monoxide, carbon dioxide, oxides of nitrogen, sulfur compounds, and particulate matter, are not emitted uniformly over the Earth, so understanding the temporal and spatial distributions is important for modeling aviation’s climate impacts. Global commercial aircraft emission data for 2004 and 2006, provided by the Volpe National Transportation Systems Center, were computed using the Federal Aviation Administration’s Aviation Environmental Design Tool (AEDT). Continuous improvement in methodologies, including changes in AEDT’s horizontal track methodologies, and an increase in availability of data make some differences between the 2004 and 2006 inventories incomparable. Furthermore, the 2004 inventory contained a significant over-count due to an imperfect data merge and daylight savings error. As a result, the 2006 emissions inventory is considered more representative of actual flight activity. Here, we analyze both 2004 and 2006 emissions, focusing on the latter, and provide corrected totals for 2004. Analysis of 2006 flight data shows that 92.5% of fuel was burned in the Northern Hemisphere, 69.0% between 30N and 60N latitudes, and 74.6% was burned above 7 km. This activity led to 162.25 Tg of carbon from CO 2 emitted globCorrespondence to: J. T. Wilkerson (wilkejt1@stanford.edu) ally in 2006, more than half over three regions: the United States (25.5%), Europe (14.6), and East Asia (11.1). Despite receiving less than one percent of global emissions, the Arctic receives a uniformly dispersed concentration of emissions with 95.2% released at altitude where they have longer residence time than surface emissions. Finally, 85.2% of all flights by number in 2006 were short-haul missions, yet those flights were responsible for only 39.7% of total carbon from CO2. The following is a summary of these data which illustrates the global and regional aviation emissions footprints for 2004 and 2006, and provides temporal and spatial distribution statistics.
Ramosetron Reduces Symptoms of Irritable Bowel Syndrome With Diarrhea and Improves Quality of Life in Women.

BACKGROUND & AIMS
Previous studies have indicated that serotonin-3-receptor antagonists might have a sex-specific effect in patients with irritable bowel syndrome with diarrhea (IBS-D). Alosetron has been approved for the treatment of only women, and ramosetron has been approved for the treatment for only men. We performed a randomized, placebo-controlled, phase 3 study to determine whether ramosetron reduces symptoms of IBS-D in women.


METHODS
We performed a prospective study of 576 female outpatients with IBS-D (according to the Rome III criteria), from February 2013 through February 2014, at 70 academic Gastroenterology Departments in Japan. After a 1-week baseline period, subjects received either 2.5 μg ramosetron (n = 292) or placebo (n = 284) once daily for 12 weeks. Primary end points were the monthly rates of response for relief from overall IBS symptoms and increased stool consistency at the last evaluation point. Quality of life (QOL) also was quantified.


RESULTS
A significantly higher proportion of patients given ramosetron reported global improvement (50.7%; 95% confidence interval [CI], 44.8-56.6) than patients given placebo (32.0%; 95% CI, 26.7-37.8)--a difference of 18.6% (95% CI, 10.7-26.5; P < .001). The relative risk was 1.58 (95% CI, 1.29-1.94) and the number needed to treat was 6 (95% CI, 4-10). A significantly higher proportion of patients in the ramosetron group reported increased stool consistency (40.8%; 95% CI, 35.1%-46.6%) than in the placebo group (24.3%; 95% CI, 19.4%-29.7%)--a difference of 16.5% (95% CI, 8.9%-24.0%; P < .001). Patients receiving ramosetron had significant reductions in abdominal pain and discomfort (P = .001) and greater improvement in QOL (P = .002) compared with placebo. Ramosetron induced constipation in 11.0% of patients.


CONCLUSIONS
In a randomized, placebo-controlled study of 576 women with IBS-D, 2.5 μg ramosetron per day reduced symptoms and increased stool consistency and QOL. Clinicaltrials.gov no: NCT01870895.
Topical henna for capecitabine induced hand–foot syndrome

Capecitabine is a chemotherapeutic drug for use in cancers. Hand–foot syndrome (HFS) is side effect of capecitabine which can lead the cessation of the therapy or dose reduction. Henna (Lawsonia inermis) is a traditionally used plant of Middle-East that is applied on hands and feet. Some of cancer patients in capecitabine treatment who developed HFS, we recommended to apply henna. In these patients, six patients were grade 3 HFS and four were grade 2 HFS. Complete response (CR) were seen in four of grade 3 HFS and all of grade 2; two grade 3 HFS improved to grade 1. So far, in the chemotherapy, there was no need of dose reduction and also no side effect of henna seen. Clinical improvement in these patients may relate to anti-inflammatory, antipyretic and analgesic effects of henna. Prospective studies are needed to show this therapeutic effect of henna.
Encapsualtion and reuse as viewed by Java students

Through audio-taped student interviews, this study examined beginning Java students' conceptions of object-oriented programming. Students rated programs on stylistic criteria including ease of comprehension, ease of debugging, ease of modification, ease of reuse, and overall quality of design. They also explained the reasons for their ratings. The results will be discussed and interpreted in light of previous research. Implications for instruction will also be examined.
Does an early home-based progressive resistance training program improve function following total hip replacement? Results of a randomized controlled study.

BACKGROUND
In-hospital progressive resistance training (PRT) has been shown to be an effective method of rehabilitation following hip surgery. The aim of this study was to assess whether a home-based PRT program would be beneficial in improving patients' muscle strength and physical function compared to standard rehabilitation.


METHODS
Subjects (n = 49) either received home-based PRT rehabilitation (n = 25) or standard rehabilitation (n = 24) in a prospective single blinded randomized trial carried out over a two-year period. The primary outcome measure was the maximal voluntary contraction of the operated leg quadriceps (MVCOLQ) with secondary measures of outcome being the sit to stand score (ST), timed up and go (TUG), stair climb performance (SCP), the 6 min walk test (6MWT), and lean mass of the operated leg (LM).


RESULTS
Twenty-six patients completed follow up at 1 year (n = 13 per group) for the final comparative analysis. All the outcome measures showed marked progressive improvements from the baseline measures at 9-12 months post op (Estimated effect (std error); p value)- MVCOLQ 26.50 (8.71) N p = 0.001; ST 1.37 (0.33) p = 0.0001; TUG -1.44 (0.45) s p =0.0001; SCP -3.41(0.80)s p = 0.0001; 6MWT 45.61 (6.10)m p = 0.0001; LM 20 (204)g p = 0.326) following surgery for both groups. Overall, there was no significant effect for participation in the exercise regime compared with standard care for all outcomes assessed.


CONCLUSIONS
Overall, this study demonstrated that there is no significant difference between the two groups for participation in the home-based PRT exercise programme when compared to standard care for all outcomes.


TRIAL REGISTRATION
ISRCTN 1309951. Registered February 2011.
Research on Teaching System Construction of Applied Surveying Engineering Specialty with q3Sq as the Core

In order to adapt to the application of surveying and mapping engineering specialty construction, by modifying the teaching plan, increase the content of the practice, appropriate cuts theoretical study, based on "3S" as the core of the practical teaching system construction surveying and mapping engineering major. In Shenyang Jianzhu University of surveying and mapping engineering applied transition, for example, from the theoretical teaching, practical teaching and examination method, faculty construction, etc, to develop new teaching plan and training system. The application of surveying and mapping engineering to increase the "3S" as the core of the teaching and practice content, both can meet the demand of cultivating application-oriented surveying and mapping engineering specialty teaching, and increase students' employment channels. Keywords—application type; Major in surveying and mapping engineering; 3S; Teaching system
Combining the Best of Convolutional Layers and Recurrent Layers: A Hybrid Network for Semantic Segmentation

State-of-the-art results of semantic segmentation are established by Fully Convolutional neural Networks (FCNs). FCNs rely on cascaded convolutional and pooling layers to gradually enlarge the receptive fields of neurons, resulting in an indirect way of modeling the distant contextual dependence. In this work, we advocate the use of spatially recurrent layers (i.e. ReNet layers) which directly capture global contexts and lead to improved feature representations. We demonstrate the effectiveness of ReNet layers by building a Naive deep ReNet (N-ReNet), which achieves competitive performance on Stanford Background dataset. Furthermore, we integrate ReNet layers with FCNs, and develop a novel Hybrid deep ReNet (H-ReNet). It enjoys a few remarkable properties, including full-image receptive fields, end-to-end training, and efficient network execution. On the PASCAL VOC 2012 benchmark, the H-ReNet improves the results of state-of-the-art approaches Piecewise [1], CRFasRNN [2] and DeepParsing [3] by 3.6%, 2.3% and 0.2%, respectively, and achieves the highest IoUs for 13 out of the 20 object classes.
Hepatoprotective Effect of Carrot ( Daucus carota L . ) on Paracetamol Intoxicated Rats

Plant products play a crucial role in the hepatoprotection through its antioxidants property. Therefore, search for modern medicine of plant origin with this property has become a central focus on hepatoprotection today. This study investigated to search a new hepatoprotective agent from natural sources, the methanol extract of nutitional plant, Daucus carota leaves was tested against liver damage of albino rats. Levels of serum marker enzymes i.e. SGOT, SGPT (aminotransferases), ALP (alkaline phosphatase) and TB (total bilirubin) in serum respectively. The histopathological changes of liver sections were also compared with the respective controls. 30% paracetamol induced significant (P<0.05) increase in liver enzymes alongwith the hepatic necrosis and other visible disarrangements in hepatic tissues. Simultaneously, oral treatment with kaempferol (KF) isolated from D. carota plant reversed to all the serum and liver parameters, dose-dependently, in 30% paracetamol treated rats. The biochemical results were also compared with the standard drug i.e. silymarin. These findings indicate the hepatoprotective potential of D. carota fruit against liver damage might be due to the presence of flavonoid like KF constituents.
Mathematical Modeling of Triphasic Viral Dynamics in Patients with HBeAg-Positive Chronic Hepatitis B Showing Response to 24-Week Clevudine Therapy

BACKGROUND
Modeling of short-term viral dynamics of hepatitis B with traditional biphasic model might be insufficient to explain long-term viral dynamics. The aim was to develop a novel method of mathematical modeling to shed light on the dissociation between early and long-term dynamics in previous studies.


METHODS
We investigated the viral decay pattern in 50 patients from the phase III clinical trial of 24-week clevudine therapy, who showed virological response and HBsAg decline. Immune effectors were added as a new compartment in the model equations. We determined some parameter values in the model using the non-linear least square minimization method.


RESULTS
Median baseline viral load was 8.526 Log(10)copies/mL, and on-treatment viral load decline was 5.683 Log(10)copies/mL. The median half-life of free virus was 24.89 hours. The median half-life of infected hepatocytes was 7.39 days. The viral decay patterns were visualized as triphasic curves with decreasing slopes over time: fastest decay in the first phase; slowest in the third phase; the second phase in between.


CONCLUSIONS
In the present study, mathematical modeling of hepatitis B in patients with virological response and HBsAg decline during 24-week antiviral therapy showed triphasic viral dynamics with direct introduction of immune effectors as a new compartment, which was thought to reflect the reduction of clearance rate of infected cells over time. This modeling method seems more appropriate to describe long-term viral dynamics compared to the biphasic model, and needs further validation.
Vaginal lacerations from consensual intercourse in adolescents.

OBJECTIVE
(1) To describe lacerations of the vaginal fornices, an injury known to be associated with consensual sexual intercourse, including known complications and treatment course, (2) to contrast these injuries with injuries sustained during sexual assault, and (3) to discuss the assessment of adolescent patients for sexual injuries.


METHODS
We present a case series of 4 female adolescent patients seen at a children's hospital over a period of 6 months. Each patient developed significant vaginal bleeding after sexual intercourse, and 3 of the patients presented to the emergency department with vital signs consistent with compensated shock.


RESULTS
Each patient was evaluated by pediatric surgery, and found to have a laceration of the vagina. Three of the patients described consensual intercourse prior to the onset of bleeding, and had lacerations of the vaginal fornices; these patients were determined to have injuries resulting from consensual sexual intercourse. The fourth patient reported sexual assault as the cause of her injuries, and was treated for longitudinal lacerations of the vaginal wall.


CONCLUSIONS
Lacerations of the upper vagina are not frequently reported in forced vaginal intercourse, but are occasionally reported as injuries sustained during consensual coitus. In the absence of reported sexual assault, a severe vaginal fornix laceration is consistent with the diagnosis of coital injury from consensual intercourse. Diagnosis and treatment of this injury can be delayed due to the sensitive nature of these injuries. Bleeding can be profuse, leading to hemorrhagic shock, and these injuries may require transfusion of blood products and surgical repair in some cases. Complications may include hemoperitoneum, pneumoperitoneum, or retroperitoneal hematoma, even in the absence of complete vaginal perforation.


PRACTICE IMPLICATIONS
Knowledge of the consensual sexual injuries that may occur in adolescent patients can guide diagnosis, treatment, and counseling for the patient and her family, preventing long-term medical complications and legal consequences.
The effects of technology use in postsecondary education: A meta-analysis of classroom applications

This meta-analysis is a study of the experimental literature of technology use in postsecondary education from 1990 up to 2010 exclusive of studies of online or distance education previously reviewed by Bernard et al. (2004). It reports the overall weighted average effects of technology use on achievement and attitude outcomes and explores moderator variables in an attempt to explain how technology treatments lead to positive or negative effects. Out of an initial pool of 11,957 study abstracts, 1105 were chosen for analysis, yielding 879 achievement and 181 attitude effect sizes after pre-experimental designs and studies with obvious methodological confounds were removed. The random effects weighted average effect size for achievement was gþ 1⁄4 0.27, k 1⁄4 879, p < .05, and for attitude outcomes it was gþ 1⁄4 0.20, k 1⁄4 181, p < .05. The collection of achievement outcomes was divided into two sub-collections, according to the amount of technology integration in the control condition. These were no technology in the control condition (k 1⁄4 479) and some technology in the control condition (k 1⁄4 400). Random effects multiple meta-regression analysis was run on each sub-collection revealing three significant predictors (subject matter, degree of difference in technology use between the treatment and the control and pedagogical uses of technology). The set of predictors for each sub-collection was both significant and homogeneous. Differences were found among the levels of all three moderators, but particularly in favor of cognitive support applications. There were no significant predictors for attitude outcomes. Crown Copyright 2013 Published by Elsevier Ltd. All rights reserved.
An empirical study on how expert knowledge affects bug reports

Bug reports are crucial software artifacts for both software maintenance researchers and practitioners. A typical use of bug reports by researchers is to evaluate automated software maintenance tools: a large repository of reports is used as input for a tool, and metrics are calculated from the tool’s output. But this process is quite different from practitioners, who distinguish between reports written by experts, such as programmers, and reports written by non-experts, such as users. Practitioners recognize that the content of a bug report depends on its author’s expert knowledge. In this paper, we present an empirical study of the textual difference between bug reports written by experts and non-experts. We find that a significant difference exists, and that this difference has a significant impact on the results from a state-of-the-art feature location tool. Through an additional study, we also found no evidence that these encountered differences were caused by the increased usage of terms from the source code in the expert bug reports. Our recommendation is that researchers evaluate maintenance tools using different sets of bug reports for experts and non-experts. Copyright c © 0000 John Wiley & Sons, Ltd.
Structure and innervation of the labia minora: more than minor skin folds.

OBJECTIVE
: The objective of this study was to examine the histologic features of the labia minora, within the context of the female sexual response.


METHODS
: Eight cadaver vulvectomy specimens were used for this study. All specimens were embedded in paraffin and were serially sectioned. Selected sections were stained with hematoxylin and eosin, elastic Masson trichrome, and S-100 antibody stains.


RESULTS
: The labia minora are thinly keratinized structures. The primary supporting tissue is collagen, with many vascular and neural elements structures throughout its core and elastin interspersed throughout.


CONCLUSIONS
: The labia minora are specialized, highly vascular folds of tissue with an abundance of neural elements. These features corroborate previous functional and observational data that the labia minora engorge with arousal and have a role in the female sexual response.
Be precise and suffer less pain! A comment on ``A brief intervention utilising visual feedback reduces pain and enhances tactile acuity in CLBP patients''.

of multisensory information can lead people to over24 generalize their responses (i.e. pain) to a sensory in25 put, which may itself contribute to the development of 26 maldaptive behavior which may lead to the develop27 ment of chronic pain [3,4]. On a similar path, the fear28 avoidance model predicts that imprecision in encoding 29 may contribute to the acquisition of pain-related fear 30 which also can contribute to development and mainte31 nance of persistent pain problems [4]. In line with as32 sumption of these models, results of the study by Trapp 33 and colleagues showed that the learned fear through 34 the imprecise association between sensory experience 35 and pain can be changed through new learning. Precise 36 encoding of sensory experiences in chronic low back 37 pain patients helped them to reduce their pain. 38
Types of coping strategies are associated with increased depressive symptoms in patients with obstructive sleep apnea.

STUDY OBJECTIVES
Some, but not all, researchers report that obstructive sleep apnea (OSA) patients experience increased depressive symptoms. Many psychological symptoms of OSA are explained in part by other OSA comorbidities (age, hypertension, body mass). People who use more passive and less active coping report more depressive symptoms. We examined relationships between coping and depressive symptoms in OSA.


SETTING
N/A.


DESIGN/PARTICIPANTS
64 OSA (respiratory disturbance index (RDI) > or = 15) patients were studied with polysomnography and completed Ways of Coping (WC), Profile of Mood States (POMS), Center for Epidemiological Studies-Depression (CESD) scales. WC was consolidated into Approach (active) and Avoidance (passive) factors. Data were analyzed using SPSS 9.0 regression with CESD as the dependent variable and WC Approach and Avoidance as the independent variables.


INTERVENTIONS
N/A.


MEASUREMENTS AND RESULTS
WC Approach factor (B=-1.105, beta=-.317, p=.009) was negatively correlated and WC Avoidance factor (B=1.353, beta=.376, p=.007) was positively correlated with CESD scores. These factors explained an additional 8% of CESD variance (p<.001) beyond that explained by the covariates: demographic variables, RDI, and fatigue (as measured by the POMS).


CONCLUSIONS
More passive and less active coping was associated with more depressive symptoms in OSA patients. The extent of depression experienced by OSA patients may not be due solely to effects of OSA itself. Choice of coping strategies may help determine who will experience more depressive symptoms.