LLukas22/scidocs huggingface dataset:
Serologic detection of Toxoplasma gondii infection in stray and household cats and its hematologic evaluation Detecção sorológica da infecção por Toxoplasma gondii em gatos errantes e domiciliados e sua avaliação hematológica

Aims: This study focused on the serologic detection of Toxoplasma gondii infection in two groups of cats: stray and household groups. In addition, hematologic assessment of seropositive and seronegative cats was done. Methods: Sixty cats were serologically tested for anti-Toxoplasma gondii antibodies using the latex agglutination test. Six collection sites for each group of cats were identified in the urban communities of Sta Rosa and San Pedro, Laguna, Philippines. The 60 cats collected were divided into 30 stray and 30 household cats. Results: Results revealed that 28 (46.67%) of the 60 cats were seropositive. There were more household cats (28.33%) which showed seropositivity compared to stray cats (18.33%), however the difference was statistically insignificant (p>0.05) . Hematologic tests through complete blood count showed significantly (p<0.05) higher number of seropositive cats with abnormalities on hemoglobin level, red blood cell count, segmenter (neutrophil) and monocyte counts compared to the control. Other parameters such as percent packed cell volume, white blood cell count, eosinophil and lymphocyte counts showed insignificant (p>0.05) results across seropositive cats and the control. Blood chemistry analysis showed significantly higher (p<0.05) potassium level irregularities in seropositive cats relative to the seronegative cats. Other parameters such as amylase, blood sugar, blood uric acid, creatinine and blood urea nitrogen were statistically insignificant (p>0.05). Conclusions: Although Toxoplasma gondii infection suggests possible cause of hematologic abnormalities, it is recommended that further studies on this aspect be done to provide more basic and clinical research information that would improve cat health management.
Investment, Inflation and Economic Growth Nexus

The paper has twofold objectives. Firstly, the impact of the inflation rate on economic growth with the possibility of two threshold levels for Pakistan using annual data from 1961 to 2008 is examined and secondly, nonlinear relationship between inflation and investment has been investigated. Inflation and growth models support the existence of a nonlinear relationship with two thresholds (6 percent and 11 percent). Inflation below the first threshold affects economic growth positively but insignificantly; at moderate rates of inflation, between the two threshold levels, the effect of inflation is significant and strongly negative and at high rates of inflation, above the second threshold, the marginal impact of additional inflation on economic growth diminishes but is still significantly negative. Investment is one of the possible channels through which inflation influences economic growth and the analysis indicates the nonlinear relationship between these two variables with only one threshold at 7 percent. Rate of inflation below the threshold level has positive but insignificant impact, while above the threshold it has strong negative and significant impact on the investment. Therefore, it is desirable to keep the inflation below 6 percent because it may be helpful for the achievement of robust economic growth and investment. 1 The authors are Staff Economist at Pakistan Institute of Development Economics (PIDE) Islamabad and PhD Student at Pakistan Institute of Development Economics (PIDE) Islamabad, respectively. The authors thank to Dr. Musleh ud Din Joint Director at Pakistan Institute of Development Economics (PIDE) Islamabad for valuable suggestions and Muhammad Javid Staff Economist at Pakistan Institute of Development Economics (PIDE) Islamabad for help in estimation. The authors wish to thank Dr. Mohsin S. Khan, Dr. Waqar Masood Khan and Dr. Wasim Shahid Malik for their useful comments on an earlier version
Mayo Clinic validation of the D'amico risk group classification for predicting survival following radical prostatectomy.

PURPOSE
The D'Amico risk group classification was originally developed to estimate the risk of biochemical recurrence following treatment for localized prostate cancer. We externally validated the ability of the risk groups to predict clinical progression, and cancer specific and overall survival following radical prostatectomy, and identify predictors of outcome in patients with high risk disease.


MATERIALS AND METHODS
We evaluated the records of 7,591 consecutive patients who underwent radical prostatectomy at our institution between 1987 and 2003. Postoperative survival was estimated using the Kaplan-Meier method. Cox proportional hazard regression models were used to analyze the ability of the risk groups to predict survival and to evaluate the impact of clinicopathological factors on outcome in patients at high risk.


RESULTS
Preoperative risk group stratification predicted the patient risk of biochemical and local recurrence, systemic progression, and cancer specific and overall survival (each p <0.001). The HR of death from prostate cancer after surgery in patients with high or intermediate risk disease was 11.5 (95% CI 5.9 to 22.3, p <0.0001) and 6.3 (95% CI 3.3 to 12.3, p <0.0001), respectively, compared to patients at low risk. In patients in the high risk group biopsy Gleason score (p = 0.006), pathological Gleason score (p = 0.006), pathological tumor stage (p = 0.04), positive lymph nodes (p = 0.02) and positive surgical margins (p = 0.008) predicted death from prostate cancer.


CONCLUSIONS
We validated the ability of the risk group stratification to predict disease progression and patient survival following radical prostatectomy. Additional prognostic information from surgical staging may assist in individualized postoperative management, particularly for patients at high risk.
Ideal rectangular cross-section Si-Fin channel double-gate MOSFETs fabricated using orientation-dependent wet etching

Ultranarrow and ideal rectangular cross section silicon(Si)-Fin channel double-gate MOSFETs (FXMOSFETs) have successfully been fabricated for the first time using [110]-oriented silicon-on-insulator (SOI) wafers and orientation-dependent wet etching. The transconductance (g/sub m/) normalized by 2/spl times/(Fin height) is found to be as high as 700 /spl mu/S//spl mu/m at V/sub d/=1 V in the fabricated 13-nm-thick and 82-nm-high Si- Fin channel double-gate MOSFET with a 105-nm gate length and a 2.2-nm gate oxide. The almost-ideal S-slope of 64 mV/decade is demonstrated in a 145-nm gate length device. These excellent results show that the Si-Fin channel with smooth [111]-oriented sidewalls is suitable to realize a high-performance FXMOSFET. The short-channel effects (SCEs) are effectively suppressed by reducing the Si-Fin thickness to 23 nm or less.
Mediated and direct effects of the North Atlantic Ocean on winter temperatures in northwest Europe

This study has used a multiple regression model to quantify the importance of wintertime mean North Atlantic sea-surface temperatures (SSTs) for explaining (simultaneous) variations in wintertime mean temperatures in northwestern Europe. Although wintertime temperature variations are primarily determined by atmospheric flow patterns, it has been speculated that North Atlantic SSTs might also provide some additional information. To test this hypothesis, we have attempted to explain 1900–93 variations in wintertime mean central England temperature (CET) by using multiple regression with contemporaneous winter mean North Atlantic sea-level pressures (SLPs) and SSTs as explanatory variables. With no SST information, the leading SLP patterns (including the North Atlantic oscillation) explain 63% of the total variance in winter mean CET; however, SSTs alone are capable of explaining only 16% of the variance in winter mean CET. Much of the SST effect is ‘indirect’ in that it supplies no more significant information than already contained in the mean SLP; e.g. both SLP and SST together can only explain 68% of the variance. However, there is a small (5% variance) direct effect due to SST that is not mediated by mean SLP, which has a spatial pattern resembling the Newfoundland SST pattern identified by Ratcliffe and Murray (1970. Quarterly Journal of the Royal Meteorological Society 96: 226–246). In predictive mode, however, using explanatory variables from preceding seasons, SSTs contain more information than SLP factors. On longer time scales, the variance explained by contemporaneous SST increases, but the SLP explanatory variables still provide a better model than the SST variables. Copyright  2003 Royal Meteorological Society.
Scheduling for heterogeneous Systems using constrained critical paths

A complex computing problem may be efficiently solved on a system with multiple processing elements by dividing its implementation code into several tasks or modules that execute in parallel. The modules may then be assigned to and scheduled on the processing elements so that the total execution time is minimum. Finding an optimal schedule for parallel programs is a non-trivial task and is considered to be NP-complete. For heterogeneous systems having processors with different characteristics, most of the scheduling algorithms use greedy approach to assign processors to the modules. This paper suggests a novel approach called constrained earliest finish time (CEFT) to provide better schedules for heterogeneous systems using the concept of the constrained critical paths (CCPs). In contrast to other approaches used for heterogeneous systems, the CEFT strategy takes into account a broader view of the input task graph. Furthermore, the statically generated CCPs may be efficiently scheduled in comparison with other approaches. The experimentation results show that the CEFT scheduling strategy outperforms the well-known HEFT, DLS and LMT strategies by producing shorter schedules for a diverse collection of task graphs. 2012 Elsevier B.V. All rights reserved.
Design and Analysis of a Halbach Magnetized Magnetic Screw for Artificial Heart

This paper introduces a high-force-density linear actuator for an artificial heart, which is based on the concept of a magnetic screw-nut. The novelty of the proposed magnetic screw is adaptation of Halbach permanent-magnet (PM) array disposed helically. PMs are placed on both the screw and the nut. The configuration of the newly designed magnetic screws is presented, and its electromagnetic performances are analyzed. The proposed Halbach magnetized magnetic screw is evaluated as compared with a radially magnetized magnetic screw using the time-stepping finite-element method, verifying the advantages of the proposed structure.
A Novel Evolutionary Kernel Intuitionistic Fuzzy $C$ -means Clustering Algorithm

This study proposes a novel evolutionary kernel intuitionistic fuzzy c-means clustering algorithm (EKIFCM) that combines Atanassov's intuitionistic fuzzy sets (IFSs) with kernel-based fuzzy c-means (KFCM), and genetic algorithms (GA) are optimally used simultaneously to select the parameters of the EKIFCM. The EKIFCM can obtain the advantages of intuitionistic fuzzy sets, kernel functions, and GA in actual clustering problems. Experiments on 2-D synthetic datasets and machine learning repository (http://archive.ics.uci.edu/beta/) datasets show that the proposed EKIFCM is more efficient than conventional algorithms such as the k-means (KM), FCM, Gustafson-Kessel (GK) clustering algorithm, Gath-Geva (GG) clustering algorithm, Chaira's intuitionistic fuzzy c-means (IFCM), and kernel-based fuzzy c-means with Gaussian kernel functions [KFCM(G)] in standard measurement indexes.
Post-infective and chronic fatigue syndromes precipitated by viral and non-viral pathogens: prospective cohort study.

OBJECTIVE
To delineate the risk factors, symptom patterns, and longitudinal course of prolonged illnesses after a variety of acute infections.


DESIGN
Prospective cohort study following patients from the time of acute infection with Epstein-Barr virus (glandular fever), Coxiella burnetii (Q fever), or Ross River virus (epidemic polyarthritis).


SETTING
The region surrounding the township of Dubbo in rural Australia, encompassing a 200 km geographical radius and 104,400 residents.


PARTICIPANTS
253 patients enrolled and followed at regular intervals over 12 months by self report, structured interview, and clinical assessment.


OUTCOME MEASURES
Detailed medical, psychiatric, and laboratory evaluations at six months to apply diagnostic criteria for chronic fatigue syndrome. Premorbid and intercurrent illness characteristics recorded to define risk factors for chronic fatigue syndrome. Self reported illness phenotypes compared between infective groups.


RESULTS
Prolonged illness characterised by disabling fatigue, musculoskeletal pain, neurocognitive difficulties, and mood disturbance was evident in 29 (12%) of 253 participants at six months, of whom 28 (11%) met the diagnostic criteria for chronic fatigue syndrome. This post-infective fatigue syndrome phenotype was stereotyped and occurred at a similar incidence after each infection. The syndrome was predicted largely by the severity of the acute illness rather than by demographic, psychological, or microbiological factors.


CONCLUSIONS
A relatively uniform post-infective fatigue syndrome persists in a significant minority of patients for six months or more after clinical infection with several different viral and non-viral micro-organisms. Post-infective fatigue syndrome is a valid illness model for investigating one pathophysiological pathway to chronic fatigue syndrome.
Some New Parallel Mechanisms Containing the Planar Four-Bar Parallelogram

A parallelogram allows the output link to remain at a fixed orientation with respect to an input link, for which it acts as a unique role in the design of parallel mechanisms. In this paper, the unique role of a parallelogram is used completely to design some new parallel mechanisms with two to six degrees of freedom (DoFs). In these mechanisms, some with three DoFs possess the advantage of very high rotational capability and some with two DoFs have the translational output of a rigid body. More than that, the design concept is also applied first to some parallel mechanisms to improve the systems’ rotational capability. The parallel mechanisms proposed in this paper have wide applications in industrial robots, simulators, micromanipulators, parallel kinematics machines, and any other manipulation devices in which high rotational capability and stiffness are needed. Especially, the paper provides new concepts of the design of novel parallel mechanisms and the improvement of rotational capability for such systems. KEY WORDS—parallel mechanism, degrees of freedom, rotational capability, mechanical design, parallelogram
The study of evasion of packed PE from static detection

Static detection of packed portable executables (PEs) relies primarily on structural properties of the packed PE, and also on anomalies in the packed PE caused by packing tools. This paper outlines weaknesses in this method of detection. We show that these structural properties and anomalies are contingent features of the executable, and can be more or less easily modified to evade static detection.
Perceived Organizational Support, Job Satisfaction, Task Performance and Organizational Citizenship Behavior in China

We examined the relationships of perceived organizational support and job satisfaction with organizational citizenship behavior and task performance in China. Employees from two large-scale state-owned enterprises (SOE) completed measures of perceived organizational support and job satisfaction and their immediate supervisors completed measures of task performance and four facets of organizational citizenship behavior. Data analyzed using zero-order correlation and hierarchical regression analysis showed positive correlations of perceived organizational support and job satisfaction with task performance, and also showed positive associations of perceived organizational support and job satisfaction with organizational citizenship behavior and each of its four dimensions.
Through the looking glass - why no wonderland? Computer applications in architecture in the USA

Abstract one objective of the paper is to survey computer-aided design activities in the USA as they apply to architectural design. Normally, such reviews limit their focus to software, and possibly hardware, developments. However, the economic and institutional environments of a country largely determine the rate and direction of research and its application, and this is especially true of computer-aided design. Thus, a second objective of the paper is to place the current efforts in the USA within this wider context. A survey is attempted, not only of the innovative research and applications of computers in architectural design, but also the context in which these developments have been taken place. Also surveyed are the changes in the environment for computer-aided architectural design that have been proposed or are taking place.
An experimental comparison of classification algorithms for imbalanced credit scoring data sets

In this paper, we set out to compare several techniques that can be used in the analysis of imbalanced credit scoring data sets. In a credit scoring context, imbalanced data sets frequently occur as the number of defaulting loans in a portfolio is usually much lower than the number of observations that do not default. As well as using traditional classification techniques such as logistic regression, neural networks and decision trees, this paper will also explore the suitability of gradient boosting, least square support vector machines and random forests for loan default prediction. Five real-world credit scoring data sets are used to build classifiers and test their performance. In our experiments, we progressively increase class imbalance in each of these data sets by randomly undersampling the minority class of defaulters, so as to identify to what extent the predictive power of the respective techniques is adversely affected. The performance criterion chosen to measure this effect is the area under the receiver operating characteristic curve (AUC); Friedman’s statistic and Nemenyi post hoc tests are used to test for significance of AUC differences between techniques. The results from this empirical study indicate that the random forest and gradient boosting classifiers perform very well in a credit scoring context and are able to cope comparatively well with pronounced class imbalances in these data sets. We also found that, when faced with a large class imbalance, the C4.5 decision tree algorithm, quadratic discriminant analysis and k-nearest neighbours perform significantly worse than the best performing classifiers. 2011 Elsevier Ltd.
A bioinspired soft actuated material.

A class of soft actuated materials that can achieve lifelike motion is presented. By embedding pneumatic actuators in a soft material inspired by a biological muscle fibril architecture, and developing a simple finite element simulation of the same, tunable biomimetic motion can be achieved with fully soft structures, exemplified here by an active left ventricle simulator.
Correlation of p53 status with outcome of neoadjuvant chemotherapy using paclitaxel and doxorubicin in stage IIIB breast cancer.

BACKGROUND
The role of p53 in modulating apoptosis has suggested that it may affect efficacy of anticancer agents. We prospectively evaluated p53 alterations in 73 patients with locally advanced breast cancer (IIIB) submitted to neoadjuvant chemotherapy.


PATIENTS AND METHODS
Patients received three cycles of paclitaxel (175 mg/m2) and doxorubicin (60 mg/m2) every 21 days. Tumor sections were analyzed before treatment for altered patterns of p53 expression using immunohistochemistry and DNA sequencing.


RESULTS
An overall response rate of 83.5% was obtained, including 15.1% complete pathological responses. The regimen was well tolerated with 17.7% grade 2/3 nausea and 12.8% grade 3/4 leukopenia. There was a statistically significant correlation between response and expression of p53. Of the 25 patients who obtained a complete clinical response, two were classified as positive (P = 0.004, chi-square). Of 11 patients who obtained a complete pathological remission, one was positive (P = 0.099, chi-square). Discussion The combination is highly effective in locally advanced breast cancer. A negative expression of p53 indicates a higher chance of responding to this regimen. The p53 status may be used as a biological marker to identify those patients who would benefit from more aggressive treatments.
The use of Likert scales with children.

OBJECTIVE
We investigated elementary school children's ability to use a variety of Likert response formats to respond to concrete and abstract items.


METHODS
111 children, aged 6-13 years, responded to 2 physical tasks that required them to make objectively verifiable judgments, using a 5-point response format. Then, using 25 items, we ascertained the consistency between responses using a "gold standard" yes/no format and responses using 5-point Likert formats including numeric values, as well as word-based frequencies, similarities to self, and agreeability.


RESULTS
All groups responded similarly to the physical tasks. For the 25 items, the use of numbers to signify agreement yielded low concordance with the yes/no answer format across age-groups. Formats based on words provided higher, but not perfect, concordance for all groups.


CONCLUSIONS
Researchers and clinicians need to be aware of the limited understanding that children have of Likert response formats.
A double-blind randomized study comparing the effects of continuing or not continuing rosiglitazone + metformin therapy when starting insulin therapy in people with Type 2 diabetes1

AIMS
To compare the efficacy and safety of either continuing or discontinuing rosiglitazone + metformin fixed-dose combination when starting insulin therapy in people with Type 2 diabetes inadequately controlled on oral therapy.


METHODS
In this 24-week double-blind study, 324 individuals with Type 2 diabetes inadequately controlled on maximum dose rosiglitazone + metformin therapy were randomly assigned to twice-daily premix insulin therapy (target pre-breakfast and pre-evening meal glucose < or = 6.5 mmol/l) in addition to either rosiglitazone + metformin (8/2000 mg) or placebo.


RESULTS
Insulin dose at week 24 was significantly lower with rosiglitazone + metformin (33.5 +/- 1.5 U/day, mean +/- se) compared with placebo [59.0 +/- 3.0 U/day; model-adjusted difference -26.6 (95% CI -37.7, -15,5) U/day, P < 0.001]. Despite this, there was greater improvement in glycaemic control [HbA(1c) rosiglitazone + metformin vs. placebo 6.8 +/- 0.1 vs. 7.5 +/- 0.1%; difference -0.7 (-0.8, -0.5)%, P < 0.001] and more individuals achieved glycaemic targets (HbA(1c) < 7.0% 70 vs. 34%, P < 0.001). The proportion of individuals reporting at least one hypoglycaemic event during the last 12 weeks of treatment was similar in the two groups (rosiglitazone + metformin vs. placebo 25 vs. 27%). People receiving rosiglitazone + metformin in addition to insulin reported greater treatment satisfaction than those receiving insulin alone. Both treatment regimens were well tolerated but more participants had oedema [12 (7%) vs. 4 (3%)] and there was more weight gain [3.7 vs. 2.6 kg; difference 1.1 (0.2, 2.1) kg, P = 0.02] with rosiglitazone + metformin.


CONCLUSIONS
Addition of insulin to rosiglitazone + metformin enabled more people to reach glycaemic targets with less insulin, and was generally well tolerated.