LLukas22/scidocs huggingface dataset:
A comparison of home measurement and ambulatory monitoring of blood pressure in the adjustment of antihypertensive treatment.

BACKGROUND
The purpose of this study was to compare home and ambulatory blood pressure (BP) in the adjustment of antihypertensive treatment.


METHODS
After a 4-week washout period, patients whose untreated daytime diastolic ambulatory BP averaged > or = 85 mm Hg were randomized to be treated according to their ambulatory or home BP. Antihypertensive treatment was adjusted at 6-week intervals according to the mean daytime ambulatory diastolic BP or the mean home diastolic BP, depending on the patient's randomization group. If the diastolic BP stayed above 80 mm Hg, the physician blinded to randomization intensified hypertensive treatment.


RESULTS
Ninety-eight patients completed the study. During the 24-week follow-up period both systolic and diastolic BP decreased significantly within both groups (P < .001). At the end of the study, the systolic/diastolic differences between ambulatory (n = 46) and home (n = 52) BP groups in home, daytime ambulatory, night-time ambulatory, and 24-h ambulatory BP changes averaged 2.6/2.6 mm Hg, 0.6/1.7 mm Hg, 1.0/1.4 mm Hg, and 0.6/1.5 mm Hg, respectively (P range .06 to .75) A nonsignificant trend to more intensive drug therapy in the ambulatory BP group and a nonsignificant trend to larger share of patients reaching (57.7% v 43.5%, P = .16) the target pressure in the home BP group was observed due to the 3.8 mm Hg difference in ambulatory and home diastolic BP at randomization.


CONCLUSIONS
The adjustment of antihypertensive treatment based on either ambulatory or home BP measurement led to good BP control. No significant between-group differences in BP changes were seen at the end of the study. Additional research is needed to provide more conclusive results.
Obesity paradox in cancer: new insights provided by body composition.

BACKGROUND
Obesity, defined by body mass index (BMI), appears to have a paradoxical protective effect in several chronic diseases.


OBJECTIVE
We investigated the obesity paradox in cancer patients by using body composition.


DESIGN
The study was an observational study of 175 cancer patients assessed before chemotherapy. Obesity was defined as BMI (in kg/m(2)) ≥30 or fat mass index (FMI; fat mass divided by the square of height) ≥5.2 (men) and ≥8.2 (women) measured by using a bioelectrical impedance analysis. Low muscle mass (sarcopenia) was defined as fat-free mass index (fat-free mass divided by the square of height) <17.5 (men) and <15.1 (women).


RESULTS
Most patients were women (65.7%) and had a mean (±SD) age of 56.9 ± 12.8 y. According to BMI criteria, 60% of patients were overweight or obese. The median survival time for overweight (2.64 y; range: 0.23-3.16 y) and obese (2.61 y; range: 0.26-3.20 y) patients was significantly higher than for patients with a normal (2.04 y; range: 0.06-3.05 y) or low (0.52 y; range: 0.19-0.98 y) BMI (P < 0.001). Sarcopenic patients had shorter survival, regardless of their FMI. Obesity predicted higher survival rates only when sarcopenia was absent. In a multivariate Cox regression model, sarcopenia was an independent predictor of higher mortality (HR: 5.19; 95% CI: 2.58, 10.43) after we controlled for BMI, age, and tumor stage.


CONCLUSIONS
The obesity paradox is present in cancer patients only when obesity is defined by BMI. Patients with sarcopenic obesity had the poorest prognosis. Cancer patients with high mortality risk can be identified by a body-composition assessment.
[Histopathological diagnostic concordance in bone and soft tissue sarcomas between two comprehensive cancer centers from eastern and western Europe: a collaborative experience].

INTRODUCTION
This study aims to assess the degree of concordance of histological diagnosis of bone and soft tissue sarcomas between a Comprehensive Cancer Center (CCC) of Eastern Europe - not specialized in this area of pathology - and an important CCC of Western Europe, which is one of the coordinators of a clinical reference network in sarcoma pathology. The goal is to have an overview of the sarcomatous pathology in a region of Eastern Europe and to discover diagnostic discrepancies between the two centers, while determining their cause.


MATERIALS AND METHODS
The initial diagnosis was compared with the revised diagnosis on 110 specimens from 88 patients with bone or soft tissue sarcomas from East-European CCC, in a one-year period of time.


RESULTS
Complete diagnostic agreement was observed in 55 cases (62.5%), a partial agreement in 23 cases (26.1%) and a major disagreement in 10 cases (11.4%). Major discrepancies of the histological type was observed in only 3 cases (3.4%): one case of discordance benign/malignant and 2 cases of discordance mesenchymal/non mesenchymal. Minor histological discrepancies - not affecting the management of the patient - were observed in 18 cases (20.4%). A major discordance in grading - potentially changing the management of the patient - was noted in 7 cases (7.9%), and a minor discrepancy in 5 cases (5.7%).


DISCUSSIONS
Some histological types were clearly overdiagnosed, like "adult fibrosarcomas" and "malignant peripheral nerve sheet tumors" (MPNST), mostly converted after the audit into "undifferentiated spindle cell sarcomas" or other types of sarcomas. Some "unclassified" sarcomas and "undifferentiated pleomorphic sarcomas" could be re-classified with the aid of an extensive panel of antibodies. Overall, immunohistochemistry was responsible, but not in exclusivity, for half of the minor discrepancies, and for 2 out of 3 cases of major histological discrepancies. Otherwise, the main cause of discrepancies was the difficulties in the interpretation of the morphology. Molecular biology was decisive in one case. Most grading discrepancies resulted from the appreciation of the mitotic index.


CONCLUSIONS
The profile of the sarcomatous pathology in the northwest region of Romania does not appear to differ significantly from other parts of Europe or the world, but a prospective epidemiological study would be necessary to confirm this assessment. The expansion of immunohistochemical antibody panel, the over-specialization of pathologists and, in the future, the establishment of a national network of referral centers in sarcoma pathology, are required for a high level of histological diagnosis in Eastern Europe. A periodic external audit, continuing this trans-European collaboration between the two centers, would be beneficial for monitoring progress.
Plants in Heavy Metal Soils

Heavy metals have a molecular mass >5.0 g cm 3 which is distinctly higher than the average particle density of soils (2.65 g cm ). Several heavy metals such as iron (Fe), manganese (Mn), zinc (Zn), copper (Cu), cobalt (Co), or molybdenum (Mo) are essential for the growth of organisms. Others have a single function and only in some organisms such as vanadium (V) in some peroxidases and in Vnitrogenases or nickel (Ni) in hydrogenases. The remainder of the heavy metals is always toxic to organisms: cadmium (Cd), lead (Pb), uranium (U), thallium (Tl), chromium (Cr), silver (Ag), and mercury (Hg). Arsenic (As) and selenium (Se) are nonheavy metals. However, since they partly share toxicity features with heavy metals, they are often referred to as “metalloids” in publications. All soils contain heavy metals. In nonheavy metal soils, the concentrations of Zn, Cu, Pb, Ni, Cd and Cr range between 0.0001 and 0.065%, whereas Mn and Fe can reach 0.002% and 10.0%, respectively (Ernst 1974). With the exception of iron, all heavy metals above a concentration of 0.1% in the soil become toxic to plants and therefore change the community structure of plants in a polluted habitat. However, each plant species has a specific threshold value for each heavy metal where it exerts toxicity (Ernst 1982). Plants specifically adapted to life on heavy metal-rich soils (“heavy metal soils”) are termed metallophytes. Zinc-rich soils (0.1–10.0% Zn) often contain a high content of Pb, but virtually no Cd, whereas soils with a high copper content (0.1–3.2% Cu) have higher concentrations of other heavy metals such a Zn, Pb, Co, Ni including Cd (Ernst 1974). Soils that carry metallophytes can be classified by the content of their main heavy metal: serpentine soils are rich in Ni, seleniferous soils carry Se, calamine
The Validity of Beck Depression Inventory and Hamilton Rating Scale for Depression Items in the Assessment of Depression Among Patients with Multiple Sclerosis

Measuring depression in patients with chronic illnesses such as multiple sclerosis (MS) is potentially complicated by the fact that several somatic symptoms of depression are also common in chronic illnesses. Whether standard assessment measures such as the Beck Depression Inventory (BDI) and Hamilton Rating Scale for Depression (HRSD) should exclude certain somatic symptoms when used in MS has been examined previously, but there is no clear consensus on this issue. The present study evaluated the utility of individual BDI and HRSD items for assessing depression in MS patients by examining how individual items responded to depression treatment in 42 (29 female) depressed MS patients. All 21 BDI items and 12 of 17 HRSD items decreased significantly with treatment, suggesting that all BDI items tap depression, as do 12 of 17 HRSD items. Thus, the present data support the inclusion of all BDI items when measuring depression in MS. Decisions on whether or not to use all HRSD items or only the 12 shown here to capture depression may depend on the study purpose and design.
Human herpesvirus-8: detection of novel herpesvirus-like DNA sequences in Kaposi's sarcoma and other lesions

Kaposi's sarcoma (KS) is a malignancy suspected of having an infectious etiology. Unique viral DNA sequences were recognized in KS lesions, using a novel technique that identifies small differences between two complex genomes. The virus had homology with the herpesvirus family, especially Epstein Barr virus (EBV), yet it was distinct from the known herpesviridae, and was appropriately named human herpesvirus 8 (HHV-8) or Kaposi's sarcoma-associated herpesvirus (KSHV). HHV-8 DNA sequences were present in AIDS-associated KS, classic KS, African endemic KS, Mediterranean KS, iatrogenic KS, and KS in homosexual men without HIV infection. HHV-8 DNA sequences were also present in peripheral blood mononuclear cells (PBMC) of KS+ patients; body-cavity-based lymphomas in HIV positive patients without KS; and in tissue from a number of malignant and non-malignant lesions in patients without HIV infection. The role of HHV-8 in KS and other malignancies is not known. Viruses are notoriously trophic for lesional tissue. Therefore, in order to determine the role of HHV-8 in KS pathogenesis, HHV-8 needs to be isolated and shown to induce immortalization in a suitable system. Regardless of its role in KS, another human herpesvirus has been discovered, and the extent of its pathogenicity needs to be uncovered.
Effects of rhizobium inoculation, sulfur and phosphorus applications on yield, yield components and nutrient uptakes in chickpea ( Cicer arietinum L.)

This study was carried out to determine the effects of sulfur and phosphorus application and rhizobium inoculation for a chickpea variety, Aziziye-94, under Eastern Turkey conditions in 2004 and 2005. The trial was laid out in split-split block design with three replications. Chickpea variety was applied on three different sulfur levels (0, 50 and 100 kg ha), phosphorus levels (0, 40 and 80 kg ha) and inoculation (inoculated and uninoculated). Whereas the highest grain yield were obtained from 80 kg ha 1 P with 819 kg ha from 100 kg ha S with 758 and from inoculation with 723 kg ha. In the first year, they were obtained from 80 kg ha P with 879 kg ha from 100 kg ha S with 818 and from inoculation with 784 kg ha in the second year. Nutrient uptake by grain of chickpea significantly increased due to sulfur doses, except for P uptake in grain at the year of 2004 and S uptake in grain at the year of 2005. Sulfur application significantly increased the uptake of Fe, Mn, Zn and Cu in grain in the both years. The effects of different doses of phosphorus application on nutrient uptakes by grain were found to be statistically significant in both years.
Purification and characterization of the kinetic parameters of cellulase produced from wheat straw by Trichoderma viride under SSF and its detergent compatibility

This paper reports the purification and characterization of kinetic parameters of cellulase produced from Trichoderma viride under still culture solid state fermentation technique using cheap and an easily available agricultural waste material, wheat straw as growth supported substrate. Trichoderma viride was cultured in fermentation medium of wheat straw under some previously optimized growth conditions and maximum activity of 398 ± 2.43 U/mL obtained after stipulated fermentation time period. Cellulase was purified 2.33 fold with specific activity of 105 U/mg in comparison to crude enzyme extract using ammonium sulfate precipitation, dialysis and Sephadex-G100 column chromatography. The enzyme was shown to have a relative low molecular weight of 58 kDa by sodium dodecyl sulphate poly-acrylamide gel electrophoresis. The purified enzyme displayed 6.5 and 55 ̊C as an optimum pH and temperature respectively. Using carboxymethyl cellulose as substrate, the enzyme showed maximum activity (Vmax) of 148 U/mL with its corresponding KM value of 68 μM. Among activators/inhibitors SDS, EDTA, and Hg showed inhibitory effect on purified cellulase whereas, the enzyme activated by Co and Mn at a concentration of 1 mM. The purified cellulase was compatible with four local detergent brands with up to 20 days of shelf life at room temperature suggesting its potential as a detergent additive for improved washing therefore, it is concluded that it may be potentially useful for industrial purposes especially for detergent and
Parasitic contamination of vegetables in Jos, Nigeria.

BACKGROUND
Intestinal parasites are very common in developing countries including Nigeria. There are diverse ways of their transmission; the study attempts to determine the level of intestinal parasitic contamination on vegetables sold in Jos.


METHODS
Sample of 200 each of Tomatoes (Lycopersium sativus), Letus (Loctus satival) Carrot (Davcus carota L) Cabbage (Brassica Denceal) and Green leafy vegetables were analyzed using standardized Centrifugal-floatation technique methods.


RESULTS
Of the 1250 samples of vegetables examined, 450 (36.0%) were positive for intestinal parasites, cabbage recorded the highest prevalence of 64% while tomatoes had the least prevalence of 20%.


CONCLUSION
Vegetables in Jos are heavily contaminated with intestinal parasites and there is need for public enlightenment campaign on the danger of consuming inadequately washed and prepared vegetables.
Spring 5-2012 Best Intentions : Health Monitoring Technology and Children .

In this paper we describe findings from two studies aimed at understanding how health monitoring technology affects the parent-child relationship, examining emotional response and barriers to using this type of technology. We present suggestions for the design of health monitoring technology intended to enhance self-care in children without creating parent-child conflict. Our recommendations integrate the study findings, developmental stage specific concerns, and prior HCI research aimed at children’s health. Author
Fashion Coordinates Recommender System Using Photographs from Fashion Magazines

Fashion magazines contain a number of photographs of fashion models, and their clothing coordinates serve as useful references. In this paper, we propose a recommender system for clothing coordinates using full-body photographs from fashion magazines. The task is that, given a photograph of a fashion item (e.g. tops) as a query, to recommend a photograph of other fashion items (e.g. bottoms) that is appropriate to the query. With the proposed method, we use a probabilistic topic model for learning information about coordinates from visual features in each fashion item region. We demonstrate the effectiveness of the proposed method using real photographs from a fashion magazine and two fashion style sharing services with the task of making top (bottom) recommendations given bottom (top) photographs.
Chiral extrapolations and the covariant small scale expansion

Abstract We calculate the nucleon and the delta mass to fourth order in a covariant formulation of the small scale expansion. We analyze lattice data from the MILC Collaboration and demonstrate that the available lattice data combined with our knowledge of the physical values for the nucleon and delta masses lead to consistent chiral extrapolation functions for both observables up to fairly large pion masses. This holds in particular for very recent data on the delta mass from the QCDSF Collaboration. The resulting pion–nucleon sigma term is σ π N = 48.9 MeV . This first quantitative analysis of the quark-mass dependence of the structure of the Δ ( 1232 ) in full QCD within chiral effective field theory suggests that (the real part of) the nucleon–delta mass-splitting in the chiral limit, Δ 0 = 0.33 GeV , is slightly larger than at the physical point. Further analysis of simultaneous fits to nucleon and delta lattice data are needed for a precision determination of the properties of the first excited state of the nucleon.
Sex-based differences in clinical practice and outcomes for Japanese patients with acute myocardial infarction undergoing primary percutaneous coronary intervention.

BACKGROUND
 Limited data are available for sex-based differences in Japanese patients with acute myocardial infarction (AMI) undergoing primary percutaneous coronary intervention (PCI).


METHODS AND RESULTS
 The study patients comprised 1,197 women and 3,182 men who underwent primary PCI for AMI in 2005-2007. Compared with the men, the women were significantly older, and had significantly longer onset-to-balloon time and lower rate of follow-up coronary angiography. In-hospital mortality was higher among women than men (8.7% vs. 4.9%, P<0.001). Although the cumulative incidence of all-cause death at 3 years was also higher for women (17.7% vs. 10.7%, P<0.001), the adjusted risk for all-cause death was comparable [hazard ratio (HR, women vs. men)=0.94, 95% confidence interval (CI): 0.71-1.24, P=0.66]. The incidence (12.1% vs. 12.4%, P=0.77) and the adjusted risk (HR=0.99, 95% CI 0.78-1.24, P=0.92) for any clinically-driven coronary revascularization were both comparable. However, regarding any non-clinically-driven coronary revascularization, the incidence (19.6% vs. 27.8%, P<0.001) and the adjusted risk (HR=0.79, 95% CI 0.65-0.95, P=0.012) were both lower in women relative to men.


CONCLUSIONS
 In current Japanese clinical practice for AMI, onset-to-balloon time was significantly longer in women than in men. Female sex was associated with lower follow-up coronary angiography rate and lower incidence of any non-clinically-driven coronary revascularization, whereas the incidence of any clinically-driven coronary revascularization was comparable between the sexes.
Rediscovering Computational Autopoiesis

This paper summarises some initial empirical results from a new computer model (arti cial chemistry) which exhibits spontaneous emergence and persistence of autopoietic organisation. The model is based on a system originally presented by Varela, Maturana and Uribe [8]. In carrying out this re-implementation it was found that an additional interaction (chain-based bond inhibition), not documented in the original description by Varela et al., is critical to the realisation of the autopoietic phenomena. This required interaction was re-discovered only following careful examination of (unpublished) source code for an early version of the original model. The purpose of the paper is thus twofold: rstly to identify and discuss this previously undocumented, but essential, interaction; and secondly to argue, on the basis of this particular case, for the importance of exploiting the emerging technologies which support publication of completely detailed software models (in addition, of course, to conventional publication of summary experimental results).
A systematic review of the content of critical appraisal tools

BACKGROUND
Consumers of research (researchers, administrators, educators and clinicians) frequently use standard critical appraisal tools to evaluate the quality of published research reports. However, there is no consensus regarding the most appropriate critical appraisal tool for allied health research. We summarized the content, intent, construction and psychometric properties of published, currently available critical appraisal tools to identify common elements and their relevance to allied health research.


METHODS
A systematic review was undertaken of 121 published critical appraisal tools sourced from 108 papers located on electronic databases and the Internet. The tools were classified according to the study design for which they were intended. Their items were then classified into one of 12 criteria based on their intent. Commonly occurring items were identified. The empirical basis for construction of the tool, the method by which overall quality of the study was established, the psychometric properties of the critical appraisal tools and whether guidelines were provided for their use were also recorded.


RESULTS
Eighty-seven percent of critical appraisal tools were specific to a research design, with most tools having been developed for experimental studies. There was considerable variability in items contained in the critical appraisal tools. Twelve percent of available tools were developed using specified empirical research. Forty-nine percent of the critical appraisal tools summarized the quality appraisal into a numeric summary score. Few critical appraisal tools had documented evidence of validity of their items, or reliability of use. Guidelines regarding administration of the tools were provided in 43% of cases.


CONCLUSIONS
There was considerable variability in intent, components, construction and psychometric properties of published critical appraisal tools for research reports. There is no "gold standard' critical appraisal tool for any study design, nor is there any widely accepted generic tool that can be applied equally well across study types. No tool was specific to allied health research requirements. Thus interpretation of critical appraisal of research reports currently needs to be considered in light of the properties and intent of the critical appraisal tool chosen for the task.
Financial early warning system model and data mining application for risk detection

One of the biggest problems of SMEs is their tendencies to financial distress because of insufficient finance background. In this study, an early warning system (EWS) model based on data mining for financial risk detection is presented. CHAID algorithm has been used for development of the EWS. Developed EWS can be served like a tailor made financial advisor in decision making process of the firms with its automated nature to the ones who have inadequate financial background. Besides, an application of the model implemented which covered 7853 SMEs based on Turkish Central Bank (TCB) 2007 data. By using EWS model, 31 risk profiles, 15 risk indicators, 2 early warning signals, and 4 financial road maps has been determined for financial risk mitigation. 2011 Elsevier Ltd. All rights reserved.
State of the art for risk management in software acquisition

This paper presents the state of the art for risk management in software acquisition. To determine it, a systematic review protocol for Software Engineering is used. Furthermore, the systematic re-view focuses on identifying initiatives and reports of risk manage-ment proposals for software acquisition in small settings. Results show increasing research in risk management and the need for more in-depth studies.