LLukas22/scidocs huggingface dataset:
The Chemokine Receptor CX3CR1 Defines Three Antigen-Experienced CD8 T Cell Subsets with Distinct Roles in Immune Surveillance and Homeostasis.

Infections induce pathogen-specific T cell differentiation into diverse effectors (Teff) that give rise to memory (Tmem) subsets. The cell-fate decisions and lineage relationships that underlie these transitions are poorly understood. Here, we found that the chemokine receptor CX3CR1 identifies three distinct CD8+ Teff and Tmem subsets. Classical central (Tcm) and effector memory (Tem) cells and their corresponding Teff precursors were CX3CR1- and CX3CR1high, respectively. Viral infection also induced a numerically stable CX3CR1int subset that represented ∼15% of blood-borne Tmem cells. CX3CR1int Tmem cells underwent more frequent homeostatic divisions than other Tmem subsets and not only self-renewed, but also contributed to the expanding CX3CR1- Tcm pool. Both Tcm and CX3CR1int cells homed to lymph nodes, but CX3CR1int cells, and not Tem cells, predominantly surveyed peripheral tissues. As CX3CR1int Tmem cells present unique phenotypic, homeostatic, and migratory properties, we designate this subset peripheral memory (tpm) cells and propose that tpm cells are chiefly responsible for the global surveillance of non-lymphoid tissues.
Unique Features of Odorant-Binding Proteins of the Parasitoid Wasp Nasonia vitripennis Revealed by Genome Annotation and Comparative Analyses

Insects are the most diverse group of animals on the planet, comprising over 90% of all metazoan life forms, and have adapted to a wide diversity of ecosystems in nearly all environments. They have evolved highly sensitive chemical senses that are central to their interaction with their environment and to communication between individuals. Understanding the molecular bases of insect olfaction is therefore of great importance from both a basic and applied perspective. Odorant binding proteins (OBPs) are some of most abundant proteins found in insect olfactory organs, where they are the first component of the olfactory transduction cascade, carrying odorant molecules to the olfactory receptors. We carried out a search for OBPs in the genome of the parasitoid wasp Nasonia vitripennis and identified 90 sequences encoding putative OBPs. This is the largest OBP family so far reported in insects. We report unique features of the N. vitripennis OBPs, including the presence and evolutionary origin of a new subfamily of double-domain OBPs (consisting of two concatenated OBP domains), the loss of conserved cysteine residues and the expression of pseudogenes. This study also demonstrates the extremely dynamic evolution of the insect OBP family: (i) the number of different OBPs can vary greatly between species; (ii) the sequences are highly diverse, sometimes as a result of positive selection pressure with even the canonical cysteines being lost; (iii) new lineage specific domain arrangements can arise, such as the double domain OBP subfamily of wasps and mosquitoes.
Internal Patch Antenna With a Thin Air-Layer Substrate for GSM/DCS Operation in a PDA Phone

A thin dual-band internal patch antenna for Global System for Mobile Communication, 890-960 MHz/Digital Communication System, 1710-1880 MHz (GSM/DCS) operation in a Personal Digital Assistant (PDA) phone is presented. The antenna can generate two wide resonant modes for GSM (890-960 MHz) and DCS (1710-1880 MHz) operation, yet it requires an air-layer substrate of thickness 4 mm only, which is among the thinnest internal mobile phone antennas that have been reported. The antenna's top patch comprises a resonant narrow strip supporting a longer resonant path for GSM operation and a resonant subpatch supporting a shorter resonant path for DCS operation. By including a suitable widened end portion for the narrow strip and a suitable tapered end portion for the subpatch, increased bandwidths for the proposed thin internal mobile phone antenna are obtained. Detailed design considerations of the proposed antenna are described. In addition, the user's hand effects on the performances of the proposed antenna are studied
An experimental phased array for OAM generation

This paper presents an experimental 8-element circular phased patch array antenna which can generate radio beams carrying mode -1 orbital angular momentum. A microstrip feeding network is used to excite the radiation elements. Both input impedance and radiation patterns are investigated based on numerical and experimental methods.
Theory of Planned Behavior and Personality

Academic misconduct in the forms of cheating and plagiarism is a large and growing problem that has been acknowledged in both the public and academic realms. In 2000, three-quarters of American college and university students said they had cheated on an exam (Williams, 2001). Additionally, according to a survey by Who’s Who Among American High School Students, more than four-fifths said cheating was common in top-rated high schools (Williams, 2001). Cheating, plagiarism and other forms of academic misconduct have been documented in several large, multi-institution survey-based studies (Davis, Grover, Becker, & McGregor, 1992; McCabe & Trevino, 1993, 1997; Whitley, 1998) as well as in a number of smaller survey and experimental studies conducted at individual institutions (Bolin, 2004; Bunn, Caudill, & Gropper, 1992; Smyth, & Davis, 2004). There has been a relative paucity of work, however, that has tried to explain academic misconduct behaviors based on a theoretical model. In the current study, we draw on Ajzen’s (1991) Theory of Planned Behavior to integrate previous research and predict academic misconduct.
Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome.

BACKGROUND
Traditional approaches to mechanical ventilation use tidal volumes of 10 to 15 ml per kilogram of body weight and may cause stretch-induced lung injury in patients with acute lung injury and the acute respiratory distress syndrome. We therefore conducted a trial to determine whether ventilation with lower tidal volumes would improve the clinical outcomes in these patients.


METHODS
Patients with acute lung injury and the acute respiratory distress syndrome were enrolled in a multicenter, randomized trial. The trial compared traditional ventilation treatment, which involved an initial tidal volume of 12 ml per kilogram of predicted body weight and an airway pressure measured after a 0.5-second pause at the end of inspiration (plateau pressure) of 50 cm of water or less, with ventilation with a lower tidal volume, which involved an initial tidal volume of 6 ml per kilogram of predicted body weight and a plateau pressure of 30 cm of water or less. The primary outcomes were death before a patient was discharged home and was breathing without assistance and the number of days without ventilator use from day 1 to day 28.


RESULTS
The trial was stopped after the enrollment of 861 patients because mortality was lower in the group treated with lower tidal volumes than in the group treated with traditional tidal volumes (31.0 percent vs. 39.8 percent, P=0.007), and the number of days without ventilator use during the first 28 days after randomization was greater in this group (mean [+/-SD], 12+/-11 vs. 10+/-11; P=0.007). The mean tidal volumes on days 1 to 3 were 6.2+/-0.8 and 11.8+/-0.8 ml per kilogram of predicted body weight (P<0.001), respectively, and the mean plateau pressures were 25+/-6 and 33+/-8 cm of water (P<0.001), respectively.


CONCLUSIONS
In patients with acute lung injury and the acute respiratory distress syndrome, mechanical ventilation with a lower tidal volume than is traditionally used results in decreased mortality and increases the number of days without ventilator use.
PAPILLON: expressive eyes for interactive characters

PAPILLON is a technology for designing highly expressive animated eyes for interactive characters, robots and toys. Expressive eyes are essential in any form of face-to-face communication [2] and designing them has been a critical challenge in robotics, as well as in interactive character and toy development.
A theoretical analysis on parameter estimation for the weibull wind speed distribution

The Weibull distribution has been found to be a suitable fit for the empirical distribution of the wind speed measurement samples. We discuss the application of the Maximum Likelihood Estimation (MLE) method and the Method of Moments (MOM) for fitting the 2-parameter Weibull distribution to wind speed measurements. We also prove that both the MLE and MOM yields unique parameter estimates.
Synthesis of High Performance Fractional-Slot Permanent-Magnet Machines With Coil-Pitch of Two Slot-Pitches

This paper presents feasible slot/pole number combinations of machines with two slot-pitches. They are becoming popular since they not only exhibit the low torque ripple but also the low harmonic content of the magnetomotive force. Some examples of such windings are reported in the literature, but they are limited to a specific slot/pole combination. On the contrary, a general theory is presented in this paper. The main rules for the design of such windings are illustrated and the relationship of slot (Ns) and pole (2p) number, and winding topologies for machines with two slot-pitches is derived. Then, the average torque, torque ripple, eddy current magnet loss, and saliency ratio of machines with slot/pole combinations Ns = 2(2p ± 1) and Ns = 2(2p ± 2) are investigated by the finite-element method and compared with the conventional one. The Ns = 2(2p ± 1) machines have the high average torque and the low-torque ripple compared with Ns = 2(2p ± 2) machines. In addition, the eddy current magnet losses for both machines are limited, and the saliency ratio of the interior permanent magnet (IPM) machine is improved compared with the conventional slot/pole number combinations. Finally, the experimental results on surface-mounted permanent magnet and IPM machines are given for validation of theoretical analyses and finite element (FE) results.
CT of agenesis and atrophy of the right hepatic lobe

Background: To identify and differentiate agenesis and severe atrophy of the right hepatic lobe on computed tomography (CT). Methods: The CT examinations of three cases of agenesis and 11 cases of severe atrophy of the right hepatic lobe were reviewed. We evaluated visibility of the three hepatic veins, the two main portal veins (including their branches if necessary), the dilated intrahepatic ducts, enlargement of the medial and lateral segments of the left lobe and caudate lobe of the liver, presence of a retrohepatic gallbladder, hyperattenuation of the atrophic liver parenchyma, posterolateral interposition of the hepatic flexure of the colon, and upward migration of the right kidney. Results: In the three cases of agenesis, no structure can be recognized as the right hepatic vein, right portal vein, or dilated right intrahepatic ducts. In the 11 cases of severe lobar atrophy, the right portal vein (or its branches) was recognized in eight cases, the right hepatic vein in four cases, and the dilated right intrahepatic ducts in 11 cases. The degree of enlargement of the lateral segment does not necessarily change inversely with the size of the medial segment and the caudate lobe. The retrohepatic gallbladder is present in eight cases (two in agenesis and six in atrophy). The phenomenon of hyperattenuation of the atrophic liver parenchyma was noted in six cases. Conclusion: Even though a retrohepatic gallbladder and a severely distorted hepatic morphology due to compensatory hypertrophy of the left and caudate lobes may raise a suspicion of agenesis of the right lobe of the liver, absence of visualization of all of the right hepatic vein, right portal vein and its branches, and dilated right intrahepatic ducts is a prerequisite of the diagnosis of agenesis of the right hepatic lobe on CT. In severe lobar atrophy, at least one of these structures is recognizable.
Prediction of long-term clinical outcomes using simple functional exercise performance tests in patients with COPD: a 5-year prospective cohort study

The 1-min sit-to-stand (1-min STS) test and handgrip strength test have been proposed as simple tests of functional exercise performance in chronic obstructive pulmonary disease (COPD) patients. We assessed the long-term (5-year) predictive performance of the 1-min sit-to-stand and handgrip strength tests for mortality, health-related quality of life (HRQoL) and exacerbations in COPD patients. In 409 primary care patients, we found the 1-min STS test to be strongly associated with long-term morality (hazard ratio per 3 more repetitions: 0.81, 95% CI 0.65 to 0.86) and moderately associated with long-term HRQoL. Neither test was associated with exacerbations. Our results suggest that the 1-min STS test may be useful for assessing the health status and long-term prognosis of COPD patients. This study was registered at http://www.clinicaltrials.gov/ (NCT00706602, 25 June 2008).
Excellent short-term results of hip resurfacing in a selected population of young patients.

BACKGROUND
Hip resurfacing (HR) is an alternative option to total hip arthroplasty (THA) in a population of selected patients (young and/or active).


HYPOTHESIS
The short-term survivorship rate is as least as good as that for THA with no abnormal increase in serum metal ion levels.


MATERIALS AND METHODS
A continuous prospective series of 502 hip resurfacings in 481 patients mean age 48.7 years old (±10.3; 18-68) (Conserve Plus, Wright Medical Technology) was analyzed clinically, radiologically and biologically (total blood chrome, cobalt and titanium metal ion levels). Mean follow up was 4.1 years (1.9-4.9).


RESULTS
There were no dislocations. There were 5 cases of revision surgery with component replacement (including 2 infections). Implant survivorship using implant removal as the criteria (excluding infection) was 99.4% at 4 years (CI 95%: 98.1-99.8). The evaluation of metal ion levels showed a significant increase in cobalt from a preoperative level of 0.24 μg/L (0.01-3.6) to 0.86 μg/L (0.01-5.7) at the final follow-up (P<0.001). Chrome and titanium levels went from 0.68 μg/L (0.01-4.4) and 2.36 μg/L (0.39-7) to 1.28 μg/L (0.1-5.5) and 4.49 μg/L (1.29-8.21) respectively (P<0.001). All clinical scores had significantly improved at the final follow-up. Mean frontal plane cup inclination was 42.7° (35-62).


DISCUSSION
In a selected population of young and/or active patients, the short-term results of hip resurfacing are excellent. At the postoperative 4-year follow-up the rate of complications (in particular the absence of dislocations) was less than that for THA in young and/or active patients. Certain conditions must be respected to obtain these results; frontal plane cup inclination of between 40 and 45°, a femoral head diameter of at least 48 mm and good quality femoral bone.


LEVEL OF EVIDENCE
IV.
Acute lung injury and the acute respiratory distress syndrome in Ireland: a prospective audit of epidemiology and management

INTRODUCTION
The aim of this study was to describe the epidemiology and management of acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS) in Ireland.


METHODS
As part of a 10-week prospective national audit of patient demographics and organ failure incidence in intensive care in Ireland, all patients with ALI/ARDS in 14 participating centres were prospectively identified using American European Consensus Conference definitions.


RESULTS
There were 1,029 admissions during the study period; of these, 728 patients were invasively ventilated. A total of 196 (19%) patients had ALI/ARDS, and 141 of these (72%) had ALI/ARDS on admission and a further 55 (28%) developed ALI/ARDS after admission. For the patients with ALI/ARDS, the mean (+/- standard deviation) age was 58 +/- 17 years and 62% were male. The most common predisposing risk factors were pneumonia (50%) and nonpulmonary sepsis (26%). Mean (+/- standard deviation) tidal volume/kg was 7.0 +/- 1.7 ml/kg. Median (interquartile range) duration of ventilation was 6.8 (2.0 to 12.8) days. Median (interquartile range) length of stay in the intensive care unit was 10.0 (5.0 to 18.5) days. The overall intensive care unit mortality for ALI/ARDS was 32.3%. Lower baseline arterial oxygen tension/fraction of inspired oxygen ratio and higher Sequential Organ Failure Assessment scores were associated with increased mortality. Although not significant, patients receiving treatment with a statin during admission had a 73% lower odds of death (odds ratio 0.27, 95% confidence interval 0.06 to 1.21; P = 0.09).


CONCLUSION
The incidence of ALI/ARDS is high and is associated with significant mortality. Protective lung ventilation is used commonly throughout participating centres. With low tidal volume ventilation, the degree of hypoxaemia is associated with outcome. These data will inform future multicentre clinical trials in ALI/ARDS in Ireland.
Hospital variation in intravenous inotrope use for patients hospitalized with heart failure: insights from Get With The Guidelines.

BACKGROUND
Prior claims analyses suggest that the use of intravenous inotropic therapy for patients hospitalized with heart failure varies substantially by hospital. Whether differences in the clinical characteristics of the patients explain observed differences in the use of inotropic therapy is not known.


METHODS AND RESULTS
We sought to characterize institutional variation in inotrope use among patients hospitalized with heart failure before and after accounting for clinical factors of patients. Hierarchical generalized linear regression models estimated risk-standardized hospital-level rates of inotrope use within 209 hospitals participating in Get With The Guidelines-Heart Failure (GWTG-HF) registry between 2005 and 2011. The association between risk-standardized rates of inotrope use and clinical outcomes was determined. Overall, an inotropic agent was administered in 7691 of 126 564 (6.1%) heart failure hospitalizations: dobutamine 43%, dopamine 24%, milrinone 17%, or a combination 16%. Patterns of inotrope use were stable during the 7-year study period. Use of inotropes varied significantly between hospitals even after accounting for patient and hospital characteristics (median risk-standardized hospital rate, 5.9%; interquartile range, 3.7%-8.6%; range, 1.3%-32.9%). After adjusting for case-mix and hospital structural differences, model intraclass correlation indicated that 21% of the observed variation in inotrope use was potentially attributable to random hospital effects (ie, institutional preferences). Hospitals with higher risk-standardized inotrope use had modestly longer risk-standardized length of stay (P=0.005) but had no difference in risk-standardized inpatient mortality (P=0.12).


CONCLUSIONS
Use of intravenous inotropic agents during hospitalization for heart failure varies significantly among US hospitals even after accounting for patient and hospital factors.
Portfolio Management using Reinforcement Learning

In this project, we use deep Q-learning to train a neural network to manage a stock portfolio of two stocks. In most cases the neural networks performed on par with benchmarks, although some models did significantly better according in terms of raw returns.
ChillFish: A Respiration Game for Children with ADHD

Breathing exercises can help children with ADHD control their stress level, but it can be hard for a child to sustain attention throughout such an exercise. In this paper, we present ChillFish, a breath-controlled biofeedback game designed in collaboration with ADHD professionals to investigate the possibilities of combining breathing exercises and game design. Based on a pilot study with 16 adults, we found that playing ChillFish had a positive effect, helping the participants to reach a relaxed state similar to the one offered by traditional breathing exercises. Further, we analyze the opportunities and challenges of creating a tangible respiration-based controller and use it as a core game mechanic. Finally, we discuss the challenge of balancing engagement and relaxation in physically controlled games for children with ADHD in order to make a game that can be calming and still sustain their attention.
Carotid intraplaque hemorrhage predicts recurrent symptoms in patients with high-grade carotid stenosis.

BACKGROUND AND PURPOSE
Carotid intraplaque hemorrhage (IPH), known to be associated with plaque instability, may convey a higher stroke risk. The aim of this study was to assess whether the identification of IPH by MRI predicts recurrent clinical cerebrovascular events.


METHODS
Sixty-six patients with high-grade symptomatic carotid stenosis underwent MRI of the carotid arteries and were followed until carotid endarterectomy or 30 days.


RESULTS
Of the 66 patients with a median follow up of 33.5 days, 44 (66.7%) were found on MRI to have ipsilateral carotid IPH. Fifteen recurrent events were associated with ipsilateral carotid IPH. Only 2 recurrent events occurred in the absence of IPH. IPH increased the risk of recurrent ischemia (hazard ratio=4.8; 95% CI=1.1 to 20.9, P<0.05).


CONCLUSIONS
IPH as detected by MRI predicts recurrent cerebrovascular events in patients with symptomatic high-grade carotid stenosis.
Interfacial Studies of Organic Field-Effect Transistors

Interfacial Studies in Organic Field-Effect Transistors
Segment-before-Detect: Vehicle Detection and Classification through Semantic Segmentation of Aerial Images

Like computer vision before, remote sensing has been radically changed by the introduction of deep learning and, more notably, Convolution Neural Networks. Land cover classification, object detection and scene understanding in aerial images rely more and more on deep networks to achieve new state-of-the-art results. Recent architectures such as Fully Convolutional Networks can even produce pixel level annotations for semantic mapping. In this work, we present a deep-learning based segment-before-detect method for segmentation and subsequent detection and classification of several varieties of wheeled vehicles in high resolution remote sensing images. This allows us to investigate object detection and classification on a complex dataset made up of visually similar classes, and to demonstrate the relevance of such a subclass modeling approach. Especially, we want to show that deep learning is also suitable for object-oriented analysis of Earth Observation data as effective object detection can be obtained as a byproduct of accurate semantic segmentation. First, we train a deep fully convolutional network on the ISPRS Potsdam and the NZAM/ONERA Christchurch datasets and show how the learnt semantic maps can be used to extract precise segmentation of vehicles. Then, we show that those maps are accurate enough to perform vehicle detection by simple connected component extraction. This allows us to study the repartition of vehicles in the city. Finally, we train a Convolutional Neural Network to perform vehicle classification on the VEDAI dataset, and transfer its knowledge to classify the individual vehicle instances that we detected.