LLukas22/scidocs huggingface dataset:
A relational psychoanalysis perspective on the necessity of acknowledging failure in order to restore the facilitating and containing features of the intersubjective relationship (the shared third).

Relational psychoanalysis has emphasized that the analyst’s awareness of her failures in recognition and hurtful re-opening of old wounds requires of her an internal struggle with self-regulation, with her own shame and guilt. This struggle takes place in the watchful presence of someone who is (sometimes hypervigilantly) listening to and monitoring the signs of the analyst’s internal state. If, in response to the patient’s hyper-arousal, the analyst retreats from the ‘music’ of mutual regulation (Knoblauch, 2000) into a dissociative use of observation in order to calm down, the patient can feel it. If, however, we are mindful of our failures, gradually we will learn together to recover from ruptures in attunement, and thus become sensitive to and use more effectively the inexplicable gaps created by the patient’s unintegrated or warring self-parts and the analyst’s failure to contain them. Thus moments of excess that fail to evoke a mirroring knowledge can serve instead to signal the unformulated, undifferentiated malaise, despair or fear. This perspective on ruptures represents an amplification of my original articulation of the process of mutual recognition as one of breakdown and restoration of intersubjective space (Benjamin, 1988). This expanded relational perspective includes the awareness of multiple self-parts that create different dyadic pairings within the same relationship and a view of intersubjectivity that emphasizes not just the fact of mutual influence (Stolorow and Atwood) but the consciousness that that there is a bi-directional dance between patient and analyst that each person registers differently – a cocreated dance governed by what we call the third (Ogden, 1994). In previous discussions of the intersubjective third I have distinguished between ‘a primordial third’, which refers to the musical or rhythmic exchange of gestures between caretaker and child as well as the procedural principles of lawful relating that underlie it, and a ‘symbolic third’, which makes use of more developed narrative elements and involves procedural rules based on consensus, negotiation, and recognition, especially recognition of the other’s separate subjectivity (Benjamin, 2004). Because of the inevitability that things will sometimes go wrong, that we will enact frightening and shameful aspects of our internal world that both Int J Psychoanal (2009) 90:441–450 doi: 10.1111/j.1745-8315.2009.00163.x
Relationships Between Risk Factors and Fractures Differ by Type of Fracture: A Population-Based Study of 12192 Perimenopausal Women

Relationship between selected factors and fractures according to type of fracture were retrospectively examined in 12192 women aged 47–56 years responding to the baseline postal enquiry of the Kuopio Osteoporosis Study, Finland, in 1989. A total of 1358 women reported fractures sustained during the previous 9.4 years, i.e. at ages 38–57 years. The incidence of fractures per 1000 person-years was 17.2 after menopause and 9.5 before (p < 0.0001). The adjusted fracture risk was elevated in smokers versus non-smokers (OR: 1.5; (95%CI = 1.3–1.9) and in those with chronic health disorders versus the healthy (OR = 1.3; 95% CI 1.1–1.5). Long-term work disability was associated with fractures independently of health disorders (OR = 1.3; 95% CI 1.1–1.6). Anthropometric measures were not associated with the overall fracture risk. Menopause was strongly and linearly related to wrist fracture but not to ankle fracture. A 1 SD increase in body mass index decreased the risk of wrist fracture by 21% (p = 0.0001) but increased that of ankle fracture by 24% (p = 0.002). Smoking was related to ankle fracture (OR = 2.2; 95% CI 1.6–3.2) but not to wrist fracture (OR = 0.9; 95% CI 0.6–1.4). Health disorders were more markedly associated with fractures other than those of the wrist or ankle. Relationships between several risk factors and pre- and perimenopausal fractures vary by type of fracture. This may affect, for example, the comparability of studies with varying fracture profiles.
Impact of critical care nursing on 30-day mortality of mechanically ventilated older adults.

OBJECTIVES
The mortality rate for mechanically ventilated older adults in ICUs is high. A robust research literature shows a significant association between nurse staffing, nurses' education, and the quality of nurse work environments and mortality following common surgical procedures. A distinguishing feature of ICUs is greater investment in nursing care. The objective of this study is to determine the extent to which variation in ICU nursing characteristics-staffing, work environment, education, and experience-is associated with mortality, thus potentially illuminating strategies for improving patient outcomes.


DESIGN
Multistate, cross-sectional study of hospitals linking nurse survey data from 2006 to 2008 with hospital administrative data and Medicare claims data from the same period. Logistic regression models with robust estimation procedures to account for clustering were used to assess the effect of critical care nursing on 30-day mortality before and after adjusting for patient, hospital, and physician characteristics.


SETTING
Three hundred and three adult acute care hospitals in California, Florida, New Jersey, and Pennsylvania.


PATIENTS
The patient sample included 55,159 older adults on mechanical ventilation admitted to a study hospital.


INTERVENTIONS
None.


MEASUREMENTS AND MAIN RESULTS
Patients in critical care units with better nurse work environments experienced 11% lower odds of 30-day mortality than those in worse nurse work environments. Additionally, each 10% point increase in the proportion of ICU nurses with a bachelor's degree in nursing was associated with a 2% reduction in the odds of 30-day mortality, which implies that the odds on patient deaths in hospitals with 75% nurses with a bachelor's degree in nursing would be 10% lower than in hospitals with 25% nurses with a bachelor's degree in nursing. Critical care nurse staffing did not vary substantially across hospitals. Staffing and nurse experience were not associated with mortality after accounting for these other nurse characteristics.


CONCLUSIONS
Patients in hospitals with better critical care nurse work environments and higher proportions of critical care nurses with a bachelor's degree in nursing experienced significantly lower odds of death.
Association of CYP2C19 polymorphisms and lansoprazole-associated respiratory adverse effects in children.

OBJECTIVE
To determine whether cytochrome P450 (CYP)2C19 haplotype associates with lansoprazole-associated adverse event frequency.


STUDY DESIGN
Respiratory adverse events from a clinical trial of lansoprazole in children with asthma were analyzed for associations with extensive or poor metabolizer (PM) phenotype based on CYP2C19 haplotypes. Carriers of CYP2C19*2, *3, *8, or *9 alleles were PMs; carriers of 2 wild-type alleles were extensive metabolizers (EMs). Plasma concentrations of lansoprazole were determined in PM and EM phenotypes.


RESULTS
The frequency of upper respiratory infection among PMs (n = 45) was higher than that among EMs (n = 91), which in turn was higher than that in placebo subjects (n = 135; P = .0039). The frequency of sore throat (ST) was similarly distributed among EMs and PMs (P = .0015). The OR (95% CI) for upper respiratory infections in PMs was 2.46 (1.02-5.96) (P = .046); for EMs, the OR (95% CI) was 1.55 (0.86-2.79). The OR (95% CI) for ST in EMs and PMs was 2.94 (1.23-7.05, P = .016) vs 1.97 (1.09-3.55, P = .024), respectively. Mean ± SD plasma concentrations of lansoprazole were higher in PMs than in EMs: 207 ± 179 ng/mL vs 132 ± 141 ng/mL (P = .04).


CONCLUSIONS
Lansoprazole-associated upper respiratory infections and ST in children are related in part to CYP2C19 haplotype. Our data suggest that lansoprazole-associated adverse events in children may be mitigated by adjusting the conventional dose in PMs. Additional studies are required to replicate our findings.
Powering the Future with the Integrated Power System

267 ABSTRACT For the past four years, Advanced Surface Machinery Programs (SEA 03R2) has been developing the Integrated Power System (IPS) to reduce ship acquisition and life cycle costs while still meeting all ship performance requirements. IPS provides electrical power to ship service loads and electric propulsion for a wide range of ship applications including surface combatants, aircraft carriers, amphibious ships, auxiliary ships, sealift and high value commercial ships. IPS consists of an architecture and a family of modules from which affordable and high performance configurations can be developed for the full range of ship applications. Two years ago, the initial IPS concepts were presented at ASNE Day 1994. Since then, much has been learned through the Reduced Scale Advanced Development (RSAD) and Full Scale Advanced Development (FSAD) programs. This paper describes the fundamental IPS architecture, details the evolving "family of modules" and their interface standards, and outlines the "Mass Customization" based design process for achieving customer performance requirements with an affordable IPS configuration. Lcdr. Norbert Doerry, USN, Henry Robey, LCdr. John Amy, USN, and Chester Petry
Serotonergic Deficits and Impaired Passive-Avoidance Learning in Rats by MDEA: A Comparison With MDMA

The serotonergic deficits induced by 3,4-methylenedioxyethamphetamine (MDEA, "eve"), were examined and compared with 3,4 methylenedioxymethamphetamine (MDMA, "ecstasy"). A single dose of MDEA (10, 20, or 40 mg/kg IP) induced a dose-related hyperthermia, but only the highest dose significantly reduced 5-HT content and 5-HT transporter density in the frontal cortex and in the hippocampus 7 days later. Long-term serotonergic deficits were much more marked when MDEA was given repeatedly (40 mg/kg IP., b.i.d., for 4 consecutive days). Single or repeated administration of MDEA induced no change on 5-HT1A receptor density in the frontal cortex, brain stem, or hippocampus, although 3 h after both treatments plasma corticosterone levels were significantly increased. MDEA (5-20 mg/kg, IP) produced significant retention deficits in a passive-avoidance learning task. Conversely, 7 days after the repeated administration of MDEA (40 mg/kg b.i.d., for 4 consecutive days) no effect on passive-avoidance performance was observed unless rats were treated again with another dose of MDEA (20 mg/kg IP) 30 min before the training trial. The 5-HT1A receptor antagonist, WAY 100635, prevented the impairment in retention performance induced by 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), but not by MDEA or MDMA, indicating that the effect of these amphetamine derivates was not mediated by 5-HT1A receptor activation. The results suggest the risk of serotonergic dysfunction associated with MDEA abuse in humans.
Intellectual capital - defining key performance indicators for organizational knowledge assets

Measuring intellectual capital is on the agenda of most 21st century organisations. This paper takes a knowledge-based view of the firm and discusses the importance of measuring organizational knowledge assets. Knowledge assets underpin capabilities and core competencies of any organisation. Therefore, they play a key strategic role and need to be measured. This paper reviews the existing approaches for measuring knowledge based assets and then introduces the knowledge asset map which integrates existing approaches in order to achieve comprehensiveness. The paper then introduces the knowledge asset dashboard to clarify the important actor/infrastructure relationship, which elucidates the dynamic nature of these assets. Finally, the paper suggests to visualise the value pathways of knowledge assets before designing strategic key performance indicators which can then be used to test the assumed causal relationships. This will enable organisations to manage and report these key value drivers in today’s economy. Introduction In the last decade management literature has paid significant attention to the role of knowledge for global competitiveness in the 21st century. It is recognised as a durable and more sustainable strategic resource to acquire and maintain competitive advantages (Barney, 1991a; Drucker, 1988; Grant, 1991a). Today’s business world is characterised by phenomena such as e-business, globalisation, higher degrees of competitiveness, fast evolution of new technology, rapidly changing client demands, as well as changing economic and political structures. In this new context companies need to develop clearly defined strategies that will give them a competitive advantage (Porter, 2001; Barney, 1991a). For this, organisations have to understand which capabilities they need in order to gain and maintain this competitive advantage (Barney, 1991a; Prahalad and Hamel, 1990). Organizational capabilities are based on knowledge. Thus, knowledge is a resource that forms the foundation of the company’s capabilities. Capabilities combine to The Emerald Research Register for this journal is available at The current issue and full text archive of this journal is available at www.emeraldinsight.com/researchregister www.emeraldinsight.com/1463-7154.htm The authors would like to thank, Göran Roos, Steven Pike, Oliver Gupta, as well as the two anonymous reviewers for their valuable comments which helped us to improve this paper. Intellectual capital
Determinants of parental authorization for involvement of newborn infants in clinical trials.

OBJECTIVE
Parents have the right to decide on behalf of their infants whether to enroll them in controlled clinical trials. We determined the degree to which such parental decisions are influenced by risk and benefit considerations compared with other factors.


DESIGN
Cross-sectional survey.


PARTICIPANTS
Parents who had recently given or declined consent to one of three controlled trials in the neonatal intensive care unit.


INTERVENTION
Parents were asked to complete a questionnaire that consisted of 15 sociodemographic items and 13 scaled responses to statements assessing the probability and magnitude of risk and benefit as well as perceived illness severity, attitudes toward research, and the consent process.


ANALYSIS
Responses were subjected to factor analysis to identify underlying constructs. The sample was then randomly split, and multiple regression was performed on each half.


RESULTS
The response rate was 83% (103 of 124) for those who had consented and 86% (37 of 43) for those who had declined. Factor analysis yielded three factors: (1) illness severity, (2) perceptions of risk or benefit and attitudes to research, and (3) sociodemographic characteristics. Multiple linear regression showed a significant multiple correlation of consent decision (r = .502), but only the second factor contributed. The analyses on split halves of the sample were comparable. Thirty-two percent of all parents agreed with the statement, "I would prefer to have the doctors advise me whether my baby should be in the study, rather than asking me to decide."


CONCLUSIONS
In making consent decisions on behalf of their newborn infants, parents are influenced by risk and benefit assessments, attitudes toward research, and the integrity of the consent process. Illness severity or sociodemographic characteristics do not seem to be of similar importance. Rather than making the decision alone, a significant minority of parents would prefer to have the physicians advise them whether to volunteer their infants for a clinical trial.
End-to-End Instance Segmentation and Counting with Recurrent Attention

While convolutional neural networks have gained impressive success recently in solving structured prediction problems such as semantic segmentation, it remains a challenge to differentiate individual object instances in the scene. Instance segmentation is very important in a variety of applications, such as autonomous driving, image captioning, and visual question answering. Techniques that combine large graphical models with low-level vision have been proposed to address this problem; however, we propose an end-to-end recurrent neural network (RNN) architecture with an attention mechanism to model a human-like counting process, and produce detailed instance segmentations. The network is jointly trained to sequentially produce regions of interest as well as a dominant object segmentation within each region. The proposed model achieves state-of-the-art results on the CVPPP leaf segmentation dataset [12] and KITTI vehicle segmentation dataset [5].
Paradigms of shared knowledge

Collaborative learning is all about sharing knowledge. Without a shared base of knowledge (common ground), discourse itself is impossible, let alone collaborative interaction. Collaborators must share a means of communication (language), a joint focus (object-orientation), and a compatible orientation (perspective). In addition to being dependent upon the presence of existing shared knowledge, successful collaboration or collaborative learning involves the construction of new knowledge, created jointly and thereby shared by the participants. Knowledge can take many forms, not necessarily rational, propositional, explicit, factual knowledge. There is tacit and explicit knowledge, focal and background, propositional and procedural, personal and institutional, individual and group.
Effectiveness of holistic physiotherapy for low back pain.

BACKGROUND
Low back pain is a term used to designate a wide and complete assemblage of symptoms that has become a cause of disability in the 21th century man. Until recently, it was believed that low back pain caused by intervertebral disc disease and degenerative progresses. At present, an increasing number of studies are linking the condition to conditions of osteoarticular and musculoligamentous structures in the spine and the associated statics of the pelvis.


MATERIAL AND METHODS
The study compared the outcomes of two different plysiotherapeutic approaches to treatment of low pack pain in group of 60 female patients. In the experimental group, a customised programme of treatment was based on postisometric relaxation of muscles and ligaments, active mobilisation of the spine, Kibler Fold mobilisation, Kinesiology Taping and Maigne's relaxing exercises. the control group underwent electrotherapy procedures and performed a set of exercises usually recommended for low back pain. Intensity of pain and difficulty in performing daily activities were evaluated at baseline and on completion of the treatment: the measurements included mobility of the spine, static balance of the pelvis, tenderness and tension of muscles and ligaments and presence of cell-pain zones. Statistics analysis used basic statistics concerning the distribution of the examined characteristics and a comparison of means in independent groups using the Mann-Whitney U test.


RESULTS
As a result of the treatment, low back pain was reduced in about 90% of patients in the experimental group, while static balance of the pelvis, tone of the muscles and ligaments and spinal mobility improved in approximately 80% of these patients. In the control group, radiating pain decreased and ligaments in 25% of participants, white the other parameters did not change significantly. The results were statistically significant at < 0.05.


CONCLUSION
These results confirm a high holistic physiotherapy including elements of osteopathy such as post-isometric muscle relaxation, active mobilisation, Kibler Fold mobilisation, customised self-therapy and Kinesiology Taping.
Mining point-of-interest data from social networks for urban land use classification and disaggregation

Over the last few years, much online volunteered geographic information (VGI) has emerged and has been increasingly analyzed to understand places and cities, as well as human mobility and activity. However, there are concerns about the quality and usability of such VGI. In this study, we demonstrate a complete process that comprises the collection, unification, classification and validation of a type of VGI—online point-of-interest (POI) data—and develop methods to utilize such POI data to estimate disaggregated land use (i.e., employment size by category) at a very high spatial resolution (census block level) using part of the Boston metropolitan area as an example. With recent advances in activity-based land use, transportation, and environment (LUTE) models, such disaggregated land use data become important to allow LUTE models to analyze and simulate a person’s choices of work location and activity destinations and to understand policy impacts on future cities. These data can also be used as alternatives to explore economic activities at the local level, especially as government-published census-based disaggregated employment data have become less available in the recent decade. Our new approach provides opportunities for cities to estimate land use at high resolution with low cost by utilizing VGI while ensuring its quality with a certain accuracy threshold. The automatic classification of POI can also be utilized for other types of analyses on cities. 2014 Elsevier Ltd. All rights reserved.
Randomized, double-blind, placebo-controlled study to assess the efficacy and toxicity of subcutaneous ketamine in the management of cancer pain.

PURPOSE
The anesthetic ketamine is widely used for pain related to cancer, but the evidence to support its use in this setting is weak. This study aimed to determine whether ketamine is more effective than placebo when used in conjunction with opioids and standard adjuvant therapy in the management of chronic uncontrolled cancer pain. Ketamine would be considered of net benefit if it provided clinically relevant improvement in pain with limited breakthrough analgesia and acceptable toxicity.


PATIENTS AND METHODS
In this multisite, dose-escalation, double-blind, randomized, placebo-controlled phase III trial, ketamine or placebo was delivered subcutaneously over 3 to 5 days.


RESULTS
In all, 185 participants were included in the primary analysis. There was no significant difference between the proportion of positive outcomes (0.04; 95% CI, -0.10 to 0.18; P = .55) in the placebo and intervention arms (response rates, 27% [25 of 92] and 31% [29 of 93]). Pain type (nociceptive v neuropathic) was not a predictor of response. There was almost twice the incidence of adverse events worse than baseline in the ketamine group after day 1 (incidence rate ratio, 1.95; 95% CI, 1.46 to 2.61; P < .001) and throughout the study. Those receiving ketamine were more likely to experience a more severe grade of adverse event per day (odds ratio, 1.09; 95% CI, 1.00 to 1.18; P = .039). The number of patients needed to treat for one additional patient to have a positive outcome from ketamine was 25 (95% CI, six to ∞). The number needed to harm, because of toxicity-related withdrawal, was six (95% CI, four to 13).


CONCLUSION
Ketamine does not have net clinical benefit when used as an adjunct to opioids and standard coanalgesics in cancer pain.