LLukas22/scidocs huggingface dataset:
Segmented Virtual Ground Architecture for Low-Power Embedded SRAM

A new scheme to reduce the power consumption of static random access memories is presented. It is shown that using segmented virtual grounding (SVGND), it is possible to reduce both dynamic and static power consumption. The leakage power of the cells is reduced by reducing the voltage drop over a cell. The dynamic power dissipation is also reduced by eliminating the power consumption due to the discharge of the nondesired neighboring bitlines. The effectiveness of this scheme is compared to recently reported low-power schemes. It is shown that unlike those schemes, SVGND can accommodate multiple words in one row; a significant improvement in soft error rate tolerance
Leadership competencies: an introduction.

O ur goal with this column is to provide a useful, practical introduction to competency modeling, a practice that is already a mainstay in many health professions and that is likely to find expanded use within health administration in the coming years. The competency model recently made available by the Healthcare Leadership Alliance (HLA) will serve to frame subsequent installments of this column. The Alliance was formed as a partnership between six of the major healthcare leadership professional associations in administration, nursing, and medicine, including the American College of Healthcare Executives (ACHE), Healthcare Financial Management Association (HFMA), Health Information Management Systems Society (HIMSS), American Organization of Nurse Executives (AONE), American College of Physician Executives (ACPE), and Medical Group Management Association and American College of Medical Practice Executives (ACMPE). In this column, we will illustrate several of the ways competency models can be used efficiently and effectively by individual leaders, leadership teams, and organizations to support their organizational strategy. In this first installment, our focus is on clarifying what competencies are, what they can be used for, and what is currently happening within the profession related to competencies. We offer a practical definition of competencies, a task that calls for providing some historical context as well.
SUSTAINABLE ECOTOURISM ON ATLANTIC ISLANDS, WITH SPECIAL REFERENCE TO WHALE WATCHING, MARINE PROTECTED AREAS AND SANCTUARIES FOR CETACEANS

Ecotourism in the Atlantic islands region is well-established and growing. Still, in the whale watching and marine tourism sector, many so-called ecotourism enterprises fail to achieve the minimum standards required to qualify as ecotourism. In the Atlantic islands area, approximately 1.7 million people a year go whale watching, with a total expenditure of US$133 million. In this region, the 90 existing marine protected areas (MPAs) where cetaceans are present and the 59 proposed MPAs represent nearly 27 per cent of all MPAs with cetaceans worldwide. When whale watching is conducted in a sustainable manner, especially in or near a cetacean MPA, and with other regulations in place, it has the capacity to take a leading role in the development of an island-based ecotourism industry. Yet few MPAs have management plans that include strategies for sustainable ecotourism. Sustainable ecotourism depends, firstly, on the maintenance of a pristine natural environment. Using a cost benefit analysis approach (CBA), managers can enhance the benefits or values of ecotourism and reduce the costs. CBA can be a key part of a framework for sustainable ecotourism that includes a stakeholder-agreed management plan, a legal structure, such as an MPA, together with environmental legislation and a strategy for evaluating sustainability that includes periodic review. The management plan should also set a carrying capacity for ecotourism.
Profiling of phenolic compounds and their antioxidant and anticancer activities in pandan (Pandanus amaryllifolius Roxb.) extracts from different locations of Malaysia

BACKGROUND
Phytochemicals and antioxidants from plant sources are of increasing interest to consumers because of their roles in the maintenance of human health. Most of the secondary metabolites of herbs are used in a number of pharmaceutical products.


METHODS
Secondary metabolites composition and content of five flavonoids and three phenolic acids were evaluated and determined in Pandanus amaryllifolius extracts from three different locations of Malaysia by RP-HPLC; Total phenolic and total flavonoid content were determined using Folin-Ciocalteau and aluminum chloride colorimetric assay; The antioxidant activity of the extracts was determined by the ferric reducing antioxidant potential (FRAP) assay and 1,1-diphenyl-2-picrylhydrazyl (DPPH) assays. MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) Assay was employed to screen anticancer activity of extracts against MCF-7 cancer cell line.


RESULTS
Highest value of total flavonoids (TF) and total phenolics (TP) was observed in pandan extract from Bachok locattion (1.87 mg/g DW and 6.72 mg/g DW) followed by Klang (1.32 mg/g DW; 5.07 mg/g DW) and Pontian (1.12 mg/g DW; 4.88 mg/g DW). Rutin just detected from Bachok location with value of 0.082 mg/g DW. High content of epicatechin (0.035 mg/g DW) and naringin (0.325 mg/g DW) were observed from Bachok location while, highest content of catechin (0.613 mg/g DW) and kaempferol (0.278 mg/g DW) was observed in pandan extract from Klang location. The extract of pandan from Bachok exhibited highest value of gallic acid (0.423 mg/g DW) and cinnamic acid (0.084 mg/g DW). Ferrulic acid just detected from pandan extract of Bachok location with concentration of 0.281 mg/g DW. Between studied locations Bachok exhibited highest value of DPPH (64.27%) and FRAP (517.2 μm of Fe (II)/g) activity followed by Klang (52.16%; 448.6 μm of Fe (II)/g) and Pontian (50.10%; 314.8 μm of Fe (II)/g). The preliminary screening showed pandan extracts from 3 locations possessed anticancer promoting activity against MCF-7 cell line, with 78.3%, 70.5% and 67.4% inhibition rate, respectively. Maximum MCF-7cell line inhibition was observed in pandan extract from Bachok location.


CONCLUSIONS
The samples collected from the North (Bachok) exhibited the highest TP, TF antioxidant and anticancer activity while those from the Southern portion (Pontian) appeared to have the lowest content of TP, TF and antioxidant activity.
Privacy-Preserving Collaborative Path Hiding for Participatory Sensing Applications

The presence of multimodal sensors on current mobile phones enables a broad range of novel mobile applications including, e.g., monitoring noise pollution or traffic and road conditions in urban environments. Data of unprecedented quantity and quality can be collected and reported by a possible user base of billions of mobile phone subscribers worldwide. The collection of detailed sensor and location data may however compromise user privacy. In this paper, we present a decentralized mechanism to preserve location privacy during the collection of sensor readings. As most sensor readings are geotagged, we propose to exchange them between users in physical proximity in order to jumble the paths followed by the users. We evaluate different strategies to exchange and report the sensor readings to the application using real-world GPS traces of mobile users. The results demonstrate the feasibility and efficacy of our proposed scheme, which can obfuscate up to 100% of the visited locations in the best instances.
Citric acid production from whey with sugars and additives by Aspergillus niger

Citric acid (CA) production by Aspergillus niger ATCC9642 from whey with different concentrations of sucrose, glucose, fructose, galactose riboflavin, tricalcium phosphate and methanol in surface culture process was studied. It was found that whey with 15% (w/v) sucrose with or without 1% methanol was the most favourable medium producing the highest amount (106.5 g/l) of citric acid. Lower CA was produced from whey with other concentrations of sugars and other additives used. Highest biomass of A. niger was produced with the addition of riboflavins. In general, extension of the fermentation (up to 20 days) resulted in an increase in CA and biomass, and decrease in both residual sucrose and pH values.
Implantable cardioverter-defibrillators in tetralogy of Fallot.

BACKGROUND
Tetralogy of Fallot is the most common form of congenital heart disease in implantable cardioverter-defibrillator (ICD) recipients, yet little is known about the value of ICDs in this patient population.


METHODS AND RESULTS
We conducted a multicenter cohort study in high-risk patients with Tetralogy of Fallot to determine actuarial rates of ICD discharges, identify risk factors, and characterize ICD-related complications. A total of 121 patients (median age 33.3 years; 59.5% male) were enrolled from 11 sites and followed up for a median of 3.7 years. ICDs were implanted for primary prevention in 68 patients (56.2%) and for secondary prevention in 53 (43.8%), defined by clinical sustained ventricular tachyarrhythmia or resuscitated sudden death. Overall, 37 patients (30.6%) received at least 1 appropriate and effective ICD discharge, with a median ventricular tachyarrhythmia rate of 213 bpm. Annual actuarial rates of appropriate ICD shocks were 7.7% and 9.8% in primary and secondary prevention, respectively (P=0.11). A higher left ventricular end-diastolic pressure (hazard ratio 1.3 per mm Hg, P=0.004) and nonsustained ventricular tachycardia (hazard ratio 3.7, P=0.023) independently predicted appropriate ICD shocks in primary prevention. Inappropriate shocks occurred in 5.8% of patients yearly. Additionally, 36 patients (29.8%) experienced complications, of which 6 (5.0%) were acute, 25 (20.7%) were late lead-related, and 7 (5.8%) were late generator-related complications. Nine patients died during follow-up, which corresponds to an actuarial annual mortality rate of 2.2%, which did not differ between the primary and secondary prevention groups.


CONCLUSIONS
Patients with tetralogy of Fallot and ICDs for primary and secondary prevention experience high rates of appropriate and effective shocks; however, inappropriate shocks and late lead-related complications are common.
Orexin A in the VTA Is Critical for the Induction of Synaptic Plasticity and Behavioral Sensitization to Cocaine

Dopamine neurons in the ventral tegmental area (VTA) represent a critical site of synaptic plasticity induced by addictive drugs. Orexin/hypocretin-containing neurons in the lateral hypothalamus project to the VTA, and behavioral studies have suggested that orexin neurons play an important role in motivation, feeding, and adaptive behaviors. However, the role of orexin signaling in neural plasticity is poorly understood. The present study shows that in vitro application of orexin A induces potentiation of N-methyl-D-aspartate receptor (NMDAR)-mediated neurotransmission via a PLC/PKC-dependent insertion of NMDARs in VTA dopamine neuron synapses. Furthermore, in vivo administration of an orexin 1 receptor antagonist blocks locomotor sensitization to cocaine and occludes cocaine-induced potentiation of excitatory currents in VTA dopamine neurons. These results provide in vitro and in vivo evidence for a critical role of orexin signaling in the VTA in neural plasticity relevant to addiction.
Collagens in the developing and diseased nervous system

Collagens are extracellular proteins characterized by a structure in triple helices. There are 28 collagen types which differ in size, structure and function. Their architectural and functional roles in connective tissues have been widely assessed. In the nervous system, collagens are rare in the vicinity of the neuronal soma, occupying mostly a “marginal” position, such as the meninges, the basement membranes and the sensory end organs. In neural development, however, where various ECM molecules are known to be determinant, recent studies indicate that collagens are no exception, participating in axonal guidance, synaptogenesis and Schwann cell differentiation. Insights on collagens function in the brain have also been derived from neural pathophysiological conditions. This review summarizes the significant advances which underscore the function and importance of collagens in the nervous system.
Disaster risk reduction : a development concern

This document is an output from a project funded by the UK Department for International Development (DFID) for the benefit of developing countries. The views expressed are not necessarily those of DFID. Contents Contents i List of tables ii List of figures ii List of boxes ii Acronyms iii Acknowledgements iv Summary 1 1. Introduction: why worry about disasters? 7 Objectives of this Study 7 Global disaster trends 7 Why donors should be concerned 9 What donors can do 9 2. What makes a disaster? 11 Characteristics of a disaster 11 Disaster risk reduction 12 The diversity of hazards 12 Vulnerability and capacity, coping and adaptation 15 Resilience 16 Poverty and vulnerability: links and differences 16 'The disaster management cycle' 17 3. Why should disasters be a development concern? 19 3.1 Disasters hold back development 19 Disasters undermine efforts to achieve the Millennium Development Goals 19 Macroeconomic impacts of disasters 21 Reallocation of resources from development to emergency assistance 22 Disaster impact on communities and livelihoods 23 3.2 Disasters are rooted in development failures 25 Dominant development models and risk 25 Development can lead to disaster 26 Poorly planned attempts to reduce risk can make matters worse 29 Disaster responses can themselves exacerbate risk 30 3.3 'Disaster-proofing' development: what are the gains? 31 From 'vicious spirals' of failed development and disaster risk… 31 … to 'virtuous spirals' of risk reduction 32 Disaster risk reduction can help achieve the Millennium Development Goals 33 … and can be cost-effective 33 4. Why does development tend to overlook disaster risk? 36 4.1 Introduction 36 4.2 Incentive, institutional and funding structures 36 Political incentives and governance in disaster prone countries 36 Government-donor relations and moral hazard 37 Donors and multilateral agencies 38 NGOs 41 4.3 Lack of exposure to and information on disaster issues 41 4.4 Assumptions about the risk-reducing capacity of development 43 ii 5. Tools for better integrating disaster risk reduction into development 45 Introduction 45 Poverty Reduction Strategy Papers (PRSPs) 45 UN Development Assistance Frameworks (UNDAFs) 47 Country assistance plans 47 National Adaptation Programmes of Action (NAPAs) 48 Partnership agreements with implementing agencies and governments 49 Programme and project appraisal guidelines 49 Early warning and information systems 49 Risk transfer mechanisms 51 International initiatives and policy forums 51 Risk reduction performance targets and indicators for donors 52 6. Conclusions and recommendations 53 6.1 Main conclusions 53 6.2 Recommendations 54 Core recommendation …
Data Mining: An Overview from a Database Perspective

Mining information and knowledge from large databases has been recognized by many researchers as a key research topic in database systems and machine learning, and by many industrial companies as an important area with an opportunity of major revenues. Researchers in many di erent elds have shown great interest in data mining. Several emerging applications in information providing services, such as data warehousing and on-line services over the Internet, also call for various data mining techniques to better understand user behavior, to improve the service provided, and to increase the business opportunities. In response to such a demand, this article is to provide a survey, from a database researcher's point of view, on the data mining techniques developed recently. A classi cation of the available data mining techniques is provided and a comparative study of such techniques is presented. Index Terms | Data mining, knowledge discovery, association rules, classi cation, data clustering, pattern matching algorithms, data generalization and characterization, data cubes, multiple-dimensional databases. J. Han was supported in part by the research grant NSERC-A3723 from the Natural Sciences and Engineering Research Council of Canada, the research grant NCE:IRIS/Precarn-HMI5 from the Networks of Centres of Excellence of Canada, and research grants from MPR Teltech Ltd. and Hughes Research Laboratories.
An Investigation into the Induction Motor of Tesla Model S Vehicle

There are no scientific publications on a electric motor in Tesla cars, so let's try to deduce something. Tesla's induction motor is very enigmatic so the paper tries to introduce a basic model. This secrecy could be interesting for the engineering and physics students. Multidisciplinary problem is considered: kinematics, mechanics, electric motors, numerical methods, control of electric drives. Identification based on three points in the steady-state torque-speed curve of the induction motor is presented. The field weakening mode of operation of the motor is analyzed. The Kloss' formula is obtained. The main aim of the article is determination of a mathematical description of the torque vs. speed curve of induction motor and its application for vehicle motion modeling. Additionally, the moment of inertia of the motor rotor and the electric vehicle mass are considered in one equation as electromechanical system. Presented approach may seem like speculation, but it allows to understand the problem of a vehicle motion. The article composition is different from classical approach - studying should be intriguing.
A multi-centre, randomised controlled trial of cognitive therapy to prevent harmful compliance with command hallucinations

BACKGROUND
Command hallucinations are among the most distressing, high risk and treatment resistant symptoms for people with psychosis; however, currently, there are no evidence-based treatment options available for this group. A cognitive therapy grounded in the principles of the Social Rank Theory, is being evaluated in terms of its effectiveness in reducing harmful compliance with command hallucinations.


METHODS/DESIGN
This is a single blind, intention-to-treat, multi-centre, randomized controlled trial comparing Cognitive Therapy for Command Hallucinations + Treatment as Usual with Treatment as Usual alone. Eligible participants have to fulfil the following inclusion criteria: i) ≥16 years; ii) ICD-10 diagnosis of schizophrenia or related disorder; iii) command hallucinations for at least 6 months leading to risk of harm to self or others. Following the completion of baseline assessments, eligible participants will be randomly allocated to either the Cognitive Therapy for Command Hallucinations + Treatment as Usual group or the Treatment as Usual group. Outcome will be assessed at 9 and 18 months post randomization with assessors blind to treatment allocation. The primary outcome is compliance behaviour and secondary outcomes include beliefs about voices' power, distress, psychotic symptoms together with a health economic evaluation. Qualitative interviews with services users will explore the acceptability of Cognitive Therapy for Command Hallucinations.


DISCUSSION
Cognitive behaviour therapy is recommended for people with psychosis; however, its focus and evaluation has primarily revolved around the reduction of psychotic symptoms. In this trial, however, the focus of the cognitive behavioural intervention is on individuals' appraisals, behaviour and affect and not necessarily symptoms; this is also reflected in the outcome measures used. If successful, the results will mark a significant breakthrough in the evidence base for service users and clinicians and will provide a treatment option for this group where none currently exist. The trial will open the way for further breakthrough work with the 'high risk' population of individuals with psychosis, which we would intend to pursue.


TRIAL REGISTRATION
ISRCTN: ISRCTN62304114.
Parkinson’s disease and the frequent reasons for emergency admission

INTRODUCTION
Available data suggest that Parkinson's disease (PD) patients have a significant socioeconomic impact owing partly to increased hospital and drug utilization. The aims of this study were to provide a profile of patients with PD who required admission to hospital and to determine the reasons for emergency admission.


PATIENTS AND METHODS
Between September 1st, 2004 and August 31st, 2006, patients with PD who were admitted to our emergency department (ED) were included in the study. Patients with PD who were diagnosed by a neurologist formerly, and admitted to the ED with any reason constituted the study population. Demographical data, reasons for admission, years exposed to PD, number of admissions to the emergency department in the past 12 months, prior Hoehn and Yahr (H&Y) scores were recorded. H&Y was performed again for all patients 4 weeks after discharge.


RESULTS
Seventy-six patients with PD were included in the study. Reasons for admission to hospital were infectious diseases (31.6%), trauma (27.6%), cardiovascular emergencies (14.5%), cerebrovascular emergencies (11.8%), gastrointestinal emergencies (7.9%), and electrolyte disturbances (6.6%), respectively. There was no dependence between the time of exposure to PD and H&Y score. Number of emergency admittance in the last 12 months was independent from the last H&Y score (p = 0.297). However, there was a dependency between the reasons for emergency admittance and the H&Y scores (p = 0.023).


DISCUSSION
H&Y score is not dependent on the emergency admittance or on the outcome after discharge from the emergency department. The motor disability by itself cannot predict the whole picture of PD and the systemic complications leading to emergency admittance.
STD/HIV control in Malawi and the search for affordable and effective urethritis therapy: a first field evaluation.

OBJECTIVES
To evaluate gonococcal (GU) and nongonococcal urethritis (NGU), chlamydia antigen, and serostatus for syphilis and human immunodeficiency virus (HIV) among males attending a Malawian STD clinic with complaints of urethral discharge and/or dysuria. To collect demographic and behavioural data and to determine the effectiveness of five treatments for urethritis.


METHODS
Urethritis was diagnosed using microscopy and culture for Neisseria gonorrhoeae. Sera were screened with rapid plasma reagin (RPR) and if reactive, with microhaemagglutination for Treponema pallidum (MHA-TP). HIV antibodies and chlamydia antigen were detected using enzyme immunoassay. Patients were randomised for treatment, cure was assessed 8-10 days later.


RESULTS
At enrolment, GU was diagnosed in 415 (80.3%) and NGU in 59 (11.2%) of 517 males. Chlamydia antigen was found in 26 (5.2%) of 497 specimens tested. Syphilis seropositivity rate (RPR and MHA-TP reactive) was 10.7%. Overall HIV seroprevalence was 44.2%; 71.7% of men with reactive syphilis serology were HIV(+) compared with 40.9% of syphilis seronegatives (OR: 3.6, p < 0.001). Trimethoprim 320 mg/sulphamethoxazole 1600 mg by mouth for 2 days (TMPSMX), or the combination of amoxicillin 3 gm, probenicid 1 gm, and clavulanate 125 mg by mouth once (APC), failed to cure gonorrhoea effectively. Amoxicillin 3 gm, probenicid 1 gm, and clavulanate 125 mg, by mouth once with doxycycline 100 mg BID for 7 days (APC-D), gentamicin 240 mg IM once (GENT), ciprofloxacin 250 mg by mouth once (CIPRO) cured 92.9% to 95% of gonorrhoea. APC-D treatment did not generate less NGU at follow-up. HIV serostatus did not affect cure of urethritis.


CONCLUSION
All patients presenting with urethritis should be treated syndromically using a simple algorithm and screened for syphilis seroreactivity for appropriate treatment and counselling.