LLukas22/scidocs huggingface dataset:
MADAPT: managed aspects for dynamic adaptation based on profiling techniques

An increasingly significant cost associated with dynamically adaptive middleware is the complexity of managing the code responsible for adaptive behaviour. It is not surprising that, due to the fine-grained nature of trace-data collection and the subtle adaptation that can result, more flexible systems are typically more complex to manage. This paper makes the case for using aspect-oriented programming (AOP) [6] as a means to achieve adaptive middleware based on fine-grained, customizable, profiling techniques. A feasibility-study combining Java Management Extensions (JMX) [3] and AOP shows the effectiveness of the synergy between the management support for application services offered by JMX, and the structured support for crosscutting concerns offered by AOP.
Inhibition of NIPBL enhances the chemosensitivity of non-small-cell lung cancer cells via the DNA damage response and autophagy pathway

Background
Previously, we reported that high expression of nipped-B-like protein (NIPBL) was strongly correlated with poor prognosis, tumor differentiation, and lymph node metastasis. Survival analysis indicated that NIPBL expression was a potential prognostic factor for non-small cell lung cancer (NSCLC). Moreover, loss of NIPBL decreased lung cancer cells proliferation, migration, invasion and promoted apoptosis as well as sensitivity to chemotherapeutic agents. However, the deep mechanisms were not explored.


Purpose
The objective of this study was to identify the role of NIPBL in DNA damage response, as well as autophagy pathway, so as to interpret the mechanisms of how NIPBL knockdown enhances the chemosensitivity of lung cancer cell.


Methods
Cells (NCI-H1299 and NCI-H1650) were transfected by specific siRNAs before immunofluorescence and single-cell gel electrophoresis, which were mainly used to observe the differences of DNA damage in different groups. Additionally, protein were obtained and then analyzed by western blot and mass spectroscopy.


Results
In this study, we found that knockdown of NIPBL resulted in accumulation of phosphorylated H2AX (γ-H2AX) foci and higher levels of DNA damage, as revealed by comet assay. Western blot assay revealed that loss of NIPBL decreased expression of ATM/ATR, Rad3-related protein and Ku70/Ku80, but increased expression of LC3-B and depletion of p62. Using mass spectroscopy, we identified eight proteins that were significantly differentially expressed upon NIPBL knockdown. Gene Ontology analysis revealed that these proteins are mainly involved in DNA repair, mismatch repair, and binding to damaged DNA. The expression changes in two of the proteins, MSH2 and STAT1, were verified by Western blotting in NIPBL-knockdown cells.


Conclusions
In summary, these results reflected that loss of NIPBL impairs the DNA damage response and promotes autophagy. And NIPBL suppression may represent a novel strategy for preventing chemotherapy resistance in lung cancer.
A phase 3, open-label, randomized trial to evaluate the safety and efficacy of levofloxacin inhalation solution (APT-1026) versus tobramycin inhalation solution in stable cystic fibrosis patients.

BACKGROUND
Inhaled antibiotics are standard of care for persons with cystic fibrosis (CF) and chronic Pseudomonas aeruginosa airway infection. APT-1026 (levofloxacin inhalation solution, LIS) is fluoroquinolone in development. We compared the safety and efficacy of LIS to tobramycin inhalation solution (TIS) in persons ≥12 years old with CF and chronic P. aeruginosa infection.


METHODS
This multinational, randomized (2:1), non-inferiority study compared LIS and TIS over three 28-day on/off cycles. Day 28 FEV(1) % predicted relative change was the primary endpoint. Time to exacerbation and patient-reported quality of life were among secondary endpoints.


RESULTS
Baseline demographics for 282 subjects were comparable. Non-inferiority was demonstrated (1.86% predicted mean FEV(1) difference [95% CI -0.66 to 4.39%]). LIS was well-tolerated, with dysgeusia (taste distortion) as the most frequent adverse event.


CONCLUSIONS
LIS is a safe and effective therapy for the management of CF patients with chronic P. aeruginosa infection.
Global Sourcing Strategy and Performance of Knowledge-Intensive Business Services: A Two-Stage Strategic Fit Model

This research contributes to the understanding of global sourcing strategy of knowledge-intensive business services (KIBSs) by offering an explanation for the differential performance among firms, even when they use similar global sourcing strategies. Using a systems integrator as the sourcing firm’s perspective, the authors argue that complex KIBSs involve a complicated mixture of interfaces in that the performance of an individual KIBS is insufficient in defining the overall performance of the integrated KIBS system. The theoretical framework uses a two-stage strategic fit model that emphasizes the conditions under which global sourcing of KIBSs influences performance. Firms that strategically coalign sourcing strategy with KIBS attributes for each KIBS activity should perform more effectively than firms that lack such a coalignment. After selecting an appropriate sourcing strategy, the firm’s dynamic capabilities (i.e., absorptive capacity and integration capability) may accentuate or attenuate the performance of the strategy at the integrated KIBS system level. Thus, although managers may be tempted to source KIBSs globally to reduce labor costs, they must examine both the KIBS attributes and the firm’s dynamic capabilities.
Wii-based Balance Therapy to Improve Balance Function of Children with
Cerebral Palsy: A Pilot Study

[Purpose] Cerebral palsy is a sensorimotor disorder that affects the control of posture and movement. The Nintendo(®) Wii Fit offers an inexpensive, enjoyable, suitable alternative to more complex systems for children with cerebral palsy. The aim of this study was to investigate the efficacacy of Wii-based balance therapy for children with ambulatory cerebral palsy. [Subjects] This pilot study design included fourteen ambulatory patients with cerebral palsy (11 males, 3 females; mean age 12.07 ± 3.36 years). [Methods] Balance functions before and after treatment were evaluated using one leg standing, the functional reach test, the timed up and go test, and the 6-minute walking test. The physiotherapist prescribed the Wii Fit activities,and supervised and supported the patients during the therapy sessions. Exercises were performed in a standardized program 2 times a week for 12 weeks. [Results] Balance ability of every patient improved. Statistically significant improvements were found in all outcome measures after 12 weeks. [Conclusion] The results suggest that the Nintendo(®) Wii Fit provides a safe, enjoyable, suitable and effective method that can be added to conventional treatments to improve the static balance of patients with cerebral palsy; however, further work is required.
Highly sensitive and selective hydrogen single-nanowire nanosensor

Metal oxides such as ZnO have been used as hydrogen sensors for a number of years. Through doping, the gas response of zinc oxide to hydrogen has been improved. Cadmium-doped ZnO nanowires (NWs) with high aspect ratio have been grown by electrodeposition. Single doped ZnO NWs have been isolated and contacted to form a nanodevice. Such nanosystem demonstrates an enhanced gas response and selectivity for the detection of hydrogen at room temperature compared to previously reported H2 nanosensors based on pure single-ZnO NWs or multiple NWs. A dependence of the gas response of a single Cd–ZnO nanowire on the NW diameter and Cd content was observed. It is shown that cadmium-doping in single-crystal zinc oxide NWs can be used to optimize their response to gases without the requirement of external heaters. The sensing mechanisms responsible for such improved response to hydrogen are
International validation of the out-of-hospital cardiac arrest score in the United States.

OBJECTIVE
Investigators in France have developed a risk score to predict death or poor neurologic outcome after out-of-hospital cardiac arrest. The aim of this study is to externally validate this score in an independent patient population in the United States.


DESIGN
Retrospective, observational, cohort study.


PATIENTS
Patients being admitted to the intensive care unit after out-of-hospital cardiac arrest.


SETTING
Two geographically distinct tertiary care hospitals in the United States.


INTERVENTIONS
None.


MEASUREMENTS AND MAIN RESULTS
The primary end point was poor outcome, defined as either death or a Cerebral Performance Category score of 3-5. The secondary end point was all-cause mortality. Calibration was assessed by comparing the number of expected outcomes based on the logistic model of the French study with observed outcomes within this study using Hosmer-Lemeshow C test (goodness-of-fit). Discrimination was assessed by calculation of the area under the receiver operating characteristic curve. Of a total of 128 patients, 99 (77%) had a poor outcome, including 91 nonsurvivors (71%). The probability of poor neurologic outcome and mortality increased stepwise with increasing out-of-hospital cardiac arrest score. Graphic display of observed against predicted outcomes and goodness-of-fit test indicated good calibration of the score (p = .4). The score showed good discrimination for poor outcome (area under the receiving operating characteristic curve, 0.85; 95% confidence interval, 0.79-0.92) and for mortality (area under the receiving operating characteristic curve, 0.85; 95% confidence interval, 0.78-0.91). In patients with an out-of-hospital cardiac arrest score >40 points and >60 points, the positive predictive value for poor outcome was 97% and 100%, respectively.


CONCLUSIONS
This study found good calibration and high discrimination of the out-of-hospital cardiac arrest score in two geographically distinct patient populations in the United States. Particularly, this score had a high positive predictive value and performed well in identifying high-risk patients for poor outcomes.
Learning Perceptual Kernels for Visualization Design

Visualization design can benefit from careful consideration of perception, as different assignments of visual encoding variables such as color, shape and size affect how viewers interpret data. In this work, we introduce perceptual kernels: distance matrices derived from aggregate perceptual judgments. Perceptual kernels represent perceptual differences between and within visual variables in a reusable form that is directly applicable to visualization evaluation and automated design. We report results from crowd-sourced experiments to estimate kernels for color, shape, size and combinations thereof. We analyze kernels estimated using five different judgment types-including Likert ratings among pairs, ordinal triplet comparisons, and manual spatial arrangement-and compare them to existing perceptual models. We derive recommendations for collecting perceptual similarities, and then demonstrate how the resulting kernels can be applied to automate visualization design decisions.
Information Technology, Production Process Outsourcing, and Manufacturing Plant Performance

What is the role of information technology (IT) in enabling the outsourcing of manufacturing plant production processes? Do plant strategies influence production outsourcing? Does production process outsourcing influence plant performance? This research addresses these questions by investigating the role of IT and plant strategies as antecedents of production outsourcing, and evaluating the impact of production outsourcing and IT investments on plant cost and quality. We develop a theoretical framework for the antecedents and outcomes of production outsourcing at the plant level. We validate this theoretical framework using cross-sectional survey data from U.S. manufacturing plants. Our analyses suggests that plants with greater IT investments are more likely to outsource their production processes, and that IT spending and production outsourcing are associated with lower plant cost of goods sold and higher product quality improvement. Our research provides an integrated model for studying the effect of IT and production outsourcing on plant performance.
Repeated cocaine exposure in vivo facilitates LTP induction in midbrain dopamine neurons

Drugs of abuse are known to cause persistent modification of neural circuits, leading to addictive behaviours. Changes in synaptic plasticity in dopamine neurons of the ventral tegmental area (VTA) may contribute to circuit modification induced by many drugs of abuse, including cocaine. Here we report that, following repeated exposure to cocaine in vivo, excitatory synapses to rat VTA dopamine neurons become highly susceptible to the induction of long-term potentiation (LTP) by correlated pre- and postsynaptic activity. This facilitated LTP induction is caused by cocaine-induced reduction of GABAA (γ-aminobutyric acid) receptor-mediated inhibition of these dopamine neurons. In midbrain slices from rats treated with saline or a single dose of cocaine, LTP could not be induced in VTA dopamine neurons unless GABA-mediated inhibition was reduced by bicuculline or picrotoxin. However, LTP became readily inducible in slices from rats treated repeatedly with cocaine; this LTP induction was prevented by enhancing GABA-mediated inhibition using diazepam. Furthermore, repeated cocaine exposure reduced the amplitude of GABA-mediated synaptic currents and increased the probability of spike initiation in VTA dopamine neurons. This cocaine-induced enhancement of synaptic plasticity in the VTA may be important for the formation of drug-associated memory.
Determining the Chemical Compositions of Garlic Plant and its Existing Active Element

In this research, we investigate the process of producing allicin in garlic. With regard to the chemical compositions of garlic (Allium Sativum L.), allicin is among the active sulfuric materials in garlic that has a lot of benefits such as anti-bacterial, anti-oxidant and deradicalizing properties.
Banks, Liquidity Management and Monetary Policy∗

We develop a new framework to study the implementation of monetary policy through the banking system. Banks make loans by issuing deposits. Loans are illiquid and, therefore, cannot be used to settle transfers of deposits. Instead, banks use central bank reserves for settlements but they may end short of reserves. This possibility induces a tradeoff between profiting from more loans against more liquidity risk exposure. Monetary policy alters this tradeoff and consequently affects aggregate credit and interest rates. In turn, banks also react to shocks that alter the distribution of payments, induce bank equity losses, increase capital requirements, and cause contractions in the loans demand. We study how the effectiveness of monetary policy varies with these shocks. We calibrate our model to study, quantitatively, why have banks increased their liquidity holdings but not increased lending despite the policy efforts of recent years.
on definitions of joint coordinate system of various joints for the reporting of human joint motion — part I : ankle , hip , and spine

The Standardization and Terminology Committee (STC) of the International Society of Biomechanics (ISB) proposes a general reporting standard for joint kinematics based on the Joint Coordinate System (JCS), first proposed by Grood and Suntay for the knee joint in 1983 (J. Biomech. Eng. 105 (1983) 136). There is currently a lack of standard for reporting joint motion in the field of biomechanics for human movement, and the JCS as proposed by Grood and Suntay has the advantage of reporting joint motions in clinically relevant terms. In this communication, the STC proposes definitions of JCS for the ankle, hip, and spine. Definitions for other joints (such as shoulder, elbow, hand and wrist, temporomandibular joint (TMJ), and whole body) will be reported in later parts of the series. The STC is publishing these recommendations so as to encourage their use, to stimulate feedback and discussion, and to facilitate further revisions. For each joint, a standard for the local axis system in each articulating bone is generated. These axes then standardize the JCS. Adopting these standards will lead to better communication among researchers and clinicians. r 2002 Elsevier Science Ltd. All rights reserved.
Sports injuries in children and adolescents.

The rapid growth of organized sports for children and adolescents in recent years is unprecedented. This growth began in North America and Europe and is now evident throughout the world. Because of a variety of social and cultural changes, many children in many of the "developed countries" will receive the majority of their exercise and physical activity in the organized sports setting. This development represents both an opportunity and a danger. The opportunity that presents itself in such a circumstance is that with careful and systematic evaluation of the physical and psychological character of each child and better understanding of the mechanical, metabolic, and psychological demands of each sport or fitness activity, sports medicine specialists might be able to match child to sport in such a way as to maximize sports safety and the child's enjoyment of sport.24 The danger of organized sport dominance, however, is that children may be exposed to inappropriate or excessive training by inexperienced or unqualified adult supervisors. This can result in sports settings and experiences that increase the risk of injury, both from acute trauma and repetitive overuse mechanisms, as well as undermine the enjoyment of the children in their sports. I fear we are closer to the latter scenario than the former at this time. We are all aware of the steady stream of sports injuries we are seeing in this age group, many of them preventable. In addition, a recent survey sponsored by the Sporting Goods Manufacturers Association found a 75% dropout rate from organized youth sports by age 15. The most frequently cited reason was that they were not fun or the child was not learning anything.6 Certainly, the potential for benefits or risks from organized sports training varies from sport to sport and from community to community. Even within certain communities, one organized sports program, such as a youth soccer
Improving self-regulated learning with a retrieval practice intervention.

Repeated retrieval practice is a powerful learning tool for promoting long-term retention, but students use this tool ineffectively when regulating their learning. The current experiments evaluated the efficacy of a minimal intervention aimed at improving students' self-regulated use of repeated retrieval practice. Across 2 experiments, students made decisions about when to study, engage in retrieval practice, or stop learning a set of foreign language word pairs. Some students received direct instruction about how to use repeated retrieval practice. These instructions emphasized the mnemonic benefits of retrieval practice over a less effective strategy (restudying) and told students how to use repeated retrieval practice to maximize their performance-specifically, that they should recall a translation correctly 3 times during learning. This minimal intervention promoted more effective self-regulated use of retrieval practice and better retention of the translations compared to a control group that received no instruction. Students who experienced this intervention also showed potential for long-term changes in self-regulated learning: They spontaneously used repeated retrieval practice 1 week later to learn new materials. These results provide a promising first step for developing guidelines for teaching students how to regulate their learning more effectively using repeated retrieval practice. (PsycINFO Database Record
The Preacher and the Farmers: The Church as a Political Arena in a Dutch Community1

This paper deals with a conflict between two groupings within the local church of a small Dutch dairy-farming community. The conflict is analyzed as a competition between two factions, each claiming a monopoly over the “truth.” It is argued that one cannot properly understand the conflict by considering only local-level processes, but must also consider their relation to nation-wide economic and theological developments.
Rates of in-hospital arrests, deaths and intensive care admissions: the effect of a medical emergency team.

OBJECTIVES
To evaluate the effectiveness of a medical emergency team (MET) in reducing the rates of selected adverse events.


DESIGN
Cohort comparison study after casemix adjustment.


PATIENTS AND SETTING
All adult (> or = 14 years) patients admitted to three Australian public hospitals from 8 July to 31 December 1996. INTERVENTION STUDIED: At Hospital 1, a medical emergency team (MET) could be called for abnormal physiological parameters or staff concern. Hospitals 2 and 3 had conventional cardiac arrest teams.


MAIN OUTCOME MEASURES
Casemix-adjusted rates of cardiac arrest, unanticipated admission to intensive care unit (ICU), death, and the subgroup of deaths where there was no pre-existing "do not resuscitate" (DNR) order documented.


RESULTS
There were 1510 adverse events identified among 50 942 admissions. The rate of unanticipated ICU admissions was less at the intervention hospital in total (casemix-adjusted odds ratios: Hospital 1, 1.00; Hospital 2, 1.59 [95% CI, 1.24-2.04]; Hospital 3, 1.73 [95% CI, 1.37-2.16]). There was no significant difference in the rates of cardiac arrest or total deaths between the three hospitals. However, one of the hospitals with a conventional cardiac arrest team had a higher death rate among patients without a DNR order.


CONCLUSIONS
The MET hospital had fewer unanticipated ICU/HDU admissions, with no increase in in-hospital arrest rate or total death rate. The non-DNR deaths were lower compared with one of the other hospitals; however, we did not adjust for DNR practices. We suggest that the MET concept is worthy of further study.
Hilbert Space Theory and Applications in Basic Quantum Mechanics

We explore the basic mathematical physics of quantum mechanics. Our primary focus will be on Hilbert space theory and applications as well as the theory of linear operators on Hilbert space. We show how Hermitian operators are used to represent quantum observables and investigate the spectrum of various linear operators. We discuss deviation and uncertainty and brieáy suggest how symmetry and representations are involved in quantum theory.
A mock circulatory system with physiological distribution of terminal resistance and compliance: application for testing the intra-aortic balloon pump.

A mock circulatory system (MCS) was designed to replicate a physiological environment for in vitro testing and was assessed with the intra-aortic balloon pump (IABP). The MCS was comprised of an artificial left ventricle (LV), connected to a 14-branch polyurethane-compound aortic model. Physiological distribution of terminal resistance and compliance according to published data was implemented with capillary tubes of different sizes and syringes of varying air volume, respectively, fitted at the outlets of the branches. The ends of the aortic branches were connected to a common tube representing the venous system and an overhead reservoir provided atrial pressure. An IABP operating a 40-cc balloon was set to counterpulsate with the LV. Total arterial compliance of the system was 0.94 mL/mm Hg and total arterial resistance was 20.3 ± 3.3 mm Hg/L/min. At control, physiological flow distribution was achieved and both mean and phasic aortic pressure and flow were physiological. With the IABP, aortic pressure exhibited the major features of counterpulsation: diastolic augmentation during inflation, inflection point at onset of deflation, and end-diastolic reduction at the end of deflation. The contribution of balloon inflation and deflation was also evident on the aortic flow pattern. This MCS was verified to be suitable for IABP testing and with further adaptations it could be used for studying other hemodynamic problems and ventricular assist devices.