LLukas22/scidocs huggingface dataset:
Association of substance use and VA service-connected disability benefits with risk of homelessness among veterans.

Recent public attention on homelessness has shifted beyond emergency services and supportive housing to primary prevention. This study compares a national sample of homeless and nonhomeless Veterans Affairs (VA) mental health services users to determine risk and protective factors for homelessness. Using VA administrative data, veterans were identified as homeless (ie, used VA homeless services or received a diagnostic code for "lack of housing") or nonhomeless and compared using logistic regression. Additional analyses were conducted for two low-risk subgroups: veterans who served in current Middle East wars (Operation Enduring Freedom [OEF]/Operation Iraqi Freedom [OIF]) and veterans with ≥50% service-connected disability. Among all VA mental health users, OEF/OIF (odds ratio [OR]) = 0.4) and ≥50% service-connected (OR = .3) veterans were less likely to be homeless. In the overall and subgroup analyses, illicit drug use (OR = 3.3-4.7) was by far the strongest predictor of homelessness, followed by pathological gambling (PG) (OR = 2.0-2.4), alcohol use disorder (OR = 1.8-2.0), and having a personality disorder (OR = 1.6-2.2). In both low-risk groups, severe mental illness (schizophrenia or bipolar disorder), along with substance use disorders, PG, and personality disorders, increased homelessness risk. Substance use, PG, and personality disorders confer the greatest modifiable risk of homelessness among veterans using VA services, while service-connected disability conferred reduced risk. Clinical prevention efforts could focus on these factors.
An Affordance-Based Methodology for Package Design

The term affordance describes an object’s utilitarian function or actionable possibilities. Product designers have taken great interest in the concept of affordances because of the bridge they provide relating to design, the interpretation of design and, ultimately, functionality in the hands of consumers. These concepts have been widely studied and applied in the field of psychology but have had limited formal application to packaging design and evaluation. We believe that the concepts related to affordances will reveal novel opportunities for packaging innovation. To catalyse this, presented work had the following objectives: (a) to propose a method by which packaging designers can purposefully consider affordances during the design process; (b) to explain this method in the context of a packaging-related case study; and (c) to measure the effect on package usability when an affordance-based design approach is employed. © 2014 The Authors. Packaging Technology and Science published by John Wiley & Sons Ltd.
Effect of zirconium on grain growth and mechanical properties of a ball-milled nanocrystalline FeNi alloy

Abstract Grain growth of ball-milled pure Fe, Fe 92 Ni 8 , and Fe 91 Ni 8 Zr 1 alloys has been studied using X-ray diffractometry (XRD), focused ion beam (FIB) microscopy and transmission electron microscopy (TEM). Mechanical properties with respect to compositional changes and annealing temperatures have been investigated using microhardness and shear punch tests. We found the rate of grain growth of the Fe 91 Ni 8 Zr 1 alloy to be much less than that of pure Fe and the Fe 92 Ni 8 alloy at elevated temperatures. The microstructure of the ternary Fe 91 Ni 8 Zr 1 alloy remains nanoscale up to 700 °C where only a few grains grow abnormally whereas annealing of pure iron and the Fe 92 Ni 8 alloy leads to extensive grain growth. The grain growth of the ternary alloy at high annealing temperatures is coupled with precipitation of Fe 2 Zr. A fine dispersion of precipitated second phase is found to promote the microstructural stability at high annealing temperatures and to increase the hardness and ultimate shear strength of ternary Fe 91 Ni 8 Zr 1 alloy drastically when the grain size is above nanoscale.
Real-time 3D SLAM for Humanoid Robot considering Pattern Generator Information

Humanoid robotics and SLAM (simultaneous localisation and mapping) are certainly two of the most significant themes of the current worldwide robotics research effort, but the two fields have up until now largely run independent parallel paths, despite the obvious benefit to be gained in joining the two. The next major step forward in humanoid robotics will be increased autonomy, and the ability of a robot to create its own world map on the fly will be a significant enabling technology. Meanwhile, SLAM techniques have found most success with robot platforms and sensor configurations which are outside of the humanoid domain. Humanoid robots move with high linear and angular accelerations in full 3D, and normally only vision is available as an outward-looking sensor. Building on recently published work on monocular SLAM using vision, and on pattern generation, we show that real-time SLAM for a humanoid can indeed be achieved. Using HRP-2, we present results in which a sparse 3D map of visual landmarks is acquired on the fly using a single camera and demonstrated loop closing and drift-free 3D motion estimation within a typical cluttered indoor environment. This is achieved by tightly coupling the pattern generator, the robot odometry and inertial sensing to aid visual mapping within a standard EKF framework. To our knowledge this is the first implementation of real-time 3D SLAM for a humanoid robot able to demonstrate loop closing
Histone Methylation by NUE, a Novel Nuclear Effector of the Intracellular Pathogen Chlamydia trachomatis

Sequence analysis of the genome of the strict intracellular pathogen Chlamydia trachomatis revealed the presence of a SET domain containing protein, proteins that primarily function as histone methyltransferases. In these studies, we demonstrated secretion of this protein via a type III secretion mechanism. During infection, the protein is translocated to the host cell nucleus and associates with chromatin. We therefore named the protein nuclear effector (NUE). Expression of NUE in mammalian cells by transfection reconstituted nuclear targeting and chromatin association. In vitro methylation assays confirmed NUE is a histone methyltransferase that targets histones H2B, H3 and H4 and itself (automethylation). Mutants deficient in automethylation demonstrated diminished activity towards histones suggesting automethylation functions to enhance enzymatic activity. Thus, NUE is secreted by Chlamydia, translocates to the host cell nucleus and has enzymatic activity towards eukaryotic substrates. This work is the first description of a bacterial effector that directly targets mammalian histones.
Effects of exenatide combined with lifestyle modification in patients with type 2 diabetes.

OBJECTIVE
To determine the effect of a lifestyle modification program plus exenatide versus lifestyle modification program plus placebo on weight loss in overweight or obese participants with type 2 diabetes treated with metformin and/or sulfonylurea.


METHODS
In this 24-week, multicenter, randomized, double-blind, placebo-controlled study, 194 patients participated in a lifestyle modification program, consisting of goals of 600 kcal/day deficit and physical activity of at least 2.5 hours/week. Participants were randomized to 5 microg exenatide twice daily injection + lifestyle modification program (n = 96) or placebo + lifestyle modification program (n = 98), and after 4 weeks increased their exenatide dose to 10 microg twice daily or volume equivalent of placebo.


RESULTS
Baseline characteristics: (mean +/- standard deviation) age, 54.8 +/- 9.5 years; weight, 95.5 +/- 16.0 kg; hemoglobin A(1c), 7.6 +/- 0.8%. At 24 weeks (least squares mean +/- standard error), treatments showed similar decreases in caloric intake (-378 +/- 58 vs -295 +/- 58 kcal/day, exenatide + lifestyle modification program vs placebo + lifestyle modification program, P = .27) and increases in exercise-derived energy expenditure. Exenatide + lifestyle modification program showed greater change in weight (-6.16 +/- 0.54 kg vs -3.97 +/- 0.52 kg, P = .003), hemoglobin A(1c) (-1.21 +/- 0.09% vs -0.73 +/- 0.09%, P <.0001), systolic (-9.44 +/- 1.40 vs -1.97 +/- 1.40 mm Hg, P <.001) and diastolic blood pressure (-2.22 +/- 1.00 vs 0.47 +/- 0.99 mm Hg, P = .04). Nausea was reported more for exenatide + lifestyle modification program than placebo + lifestyle modification program (44.8% vs 19.4%, respectively, P <.001), with no difference in withdrawal rates due to adverse events (4.2% vs 5.1%, respectively, P = 1.0) or rates of hypoglycemia.


CONCLUSIONS
When combined with lifestyle modification, exenatide treatment led to significant weight loss, improved glycemic control, and decreased blood pressure compared with lifestyle modification alone in overweight or obese participants with type 2 diabetes on metformin and/or sulfonylurea treatment.
Recommendation system for software refactoring using innovization and interactive dynamic optimization

We propose a novel recommendation tool for software refactoring that dynamically adapts and suggests refactorings to developers interactively based on their feedback and introduced code changes. Our approach starts by finding upfront a set of non-dominated refactoring solutions using NSGA-II to improve software quality, reduce the number of refactorings and increase semantic coherence. The generated non-dominated refactoring solutions are analyzed using our innovization component to extract some interesting common features between them. Based on this analysis, the suggested refactorings are ranked and suggested to the developer one by one. The developer can approve, modify or reject each suggested refactoring, and this feedback is used to update the ranking of the suggested refactorings. After a number of introduced code changes, a local search is performed to update and adapt the set of refactoring solutions suggested by NSGA-II. We evaluated this tool on four large open source systems and one industrial project provided by our partner. Statistical analysis of our experiments over 31 runs shows that the dynamic refactoring approach performed significantly better than three other search-based refactoring techniques, manual refactorings, and one refactoring tool not based on heuristic search.
VX-222, a non-nucleoside NS5B polymerase inhibitor, in telaprevir-based regimens for genotype 1 hepatitis C virus infection.

OBJECTIVE
To investigate in this phase 2a study (ZENITH) the safety, tolerability, and antiviral activity of VX-222, a selective, non-nucleoside inhibitor of hepatitis C virus (HCV) NS5B polymerase, combined with various telaprevir-based regimens for treatment of genotype 1 HCV.


METHODS
In total, 152 treatment-naive patients received VX-222+telaprevir ('DUAL' regimen; n=47), with ribavirin ('TRIPLE' regimen; n=46), or with peginterferon+ribavirin ('QUAD' regimen; n=59) for 12 weeks. Patients with detectable HCV RNA at weeks 2 and/or 8 received peginterferon+ribavirin for 24 (DUAL and TRIPLE) or 12 (QUAD) additional weeks.


RESULTS
VX-222 (100 or 400 mg twice daily) was well tolerated, with an increased rate of gastrointestinal adverse events observed with the higher dose. Across VX-222 400-mg twice-daily regimens, the QUAD was associated with the highest frequency of grade 3/4 adverse events. The DUAL was discontinued because of high viral breakthrough before week 12. Sustained virologic response (SVR) 24 weeks after end of treatment (SVR24), including patients treated with 12 or 24 additional weeks of peginterferon+ribavirin, was 67% for TRIPLE (VX-222 400 mg twice daily) and 79 and 90% for QUAD (VX-222 100 and 400 mg twice daily, respectively).


CONCLUSION
These results provide valuable information regarding the safety, tolerability, and efficacy of telaprevir combined with a non-nucleoside polymerase inhibitor, as dual therapy or with ribavirin without or with peginterferon. Telaprevir and VX-222, alone or with ribavirin without or with peginterferon, were generally well tolerated, with improved tolerability without peginterferon. SVR24 rates achieved with TRIPLE and QUAD regimens containing telaprevir and VX-222 were comparable to those observed with telaprevir-based therapy.
The occurrence of benign brain tumours in transgender individuals during cross-sex hormone treatment.

Benign brain tumours may be hormone sensitive. To induce physical characteristics of the desired gender, transgender individuals often receive cross-sex hormone treatment, sometimes in higher doses than hypogonadal individuals. To date, long-term (side) effects of cross-sex hormone treatment are largely unknown. In the present retrospective chart study we aimed to compare the incidence of common benign brain tumours: meningiomas, pituitary adenomas (non-secretive and secretive), and vestibular schwannomas in transgender individuals receiving cross-sex hormone treatment, with those reported in general Dutch or European populations. This study was performed at the VU University Medical Centre in the Netherlands and consisted of 2555 transwomen (median age at start of cross-sex hormone treatment: 31 years, interquartile range 23-41) and 1373 transmen (median age 23 years, interquartile range 18-31) who were followed for 23 935 and 11 212 person-years, respectively. For each separate brain tumour, standardized incidence ratios with 95% confidence intervals were calculated. In transwomen (male sex assigned at birth, female gender identity), eight meningiomas, one non-secretive pituitary adenoma, nine prolactinomas, and two vestibular schwannomas occurred. The incidence of meningiomas was higher in transwomen than in a general European female population (standardized incidence ratio 4.1, 95% confidence interval 1.9-7.7) and male population (11.9, 5.5-22.7). Similar to meningiomas, prolactinomas occurred more often in transwomen compared to general Dutch females (4.3, 2.1-7.9) and males (26.5, 12.9-48.6). Noteworthy, most transwomen had received orchiectomy but still used the progestogenic anti-androgen cyproterone acetate at time of diagnosis. In transmen (female sex assigned at birth, male gender identity), two cases of somatotrophinomas were observed, which was higher than expected based on the reported incidence rate in a general European population (incidence rate females = incidence rate males; standardized incidence ratio 22.2, 3.7-73.4). Based on our results we conclude that cross-sex hormone treatment is associated with a higher risk of meningiomas and prolactinomas in transwomen, which may be linked to cyproterone acetate usage, and somatotrophinomas in transmen. Because these conditions are quite rare, performing regular screenings for such tumours (e.g. regular prolactin measurements for identifying prolactinomas) seems not necessary.
Money and monetary policy: The ECB experience 1999-2006

The paper analyses the practical experience of monetary analysis at the ECB since its beginning. The analysis is based on both a narrative description of the internal briefing and a quantitative evaluation of the forecast exercise. We exploit a rich data basis containing the vintages of data and models over the period in order to evaluate the role of money in the input and the output of monetary policy as it has been in real time.
Neurocognitive mechanisms underlying value-based decision-making: from core values to economic value

VALUE PLAYS A CENTRAL ROLE IN PRACTICALLY EVERY ASPECT OF HUMAN LIFE THAT REQUIRES A DECISION: whether we choose between different consumer goods, whether we decide which person we marry or which political candidate gets our vote, we choose the option that has more value to us. Over the last decade, neuroeconomic research has mapped the neural substrates of economic value, revealing that activation in brain regions such as ventromedial prefrontal cortex (VMPFC), ventral striatum or posterior cingulate cortex reflects how much an individual values an option and which of several options he/she will choose. However, while great progress has been made exploring the mechanisms underlying concrete decisions, neuroeconomic research has been less concerned with the questions of why people value what they value, and why different people value different things. Social psychologists and sociologists have long been interested in core values, motivational constructs that are intrinsically linked to the self-schema and are used to guide actions and decisions across different situations and different time points. Core value may thus be an important determinant of individual differences in economic value computation and decision-making. Based on a review of recent neuroimaging studies investigating the neural representation of core values and their interactions with neural systems representing economic value, we outline a common framework that integrates the core value concept and neuroeconomic research on value-based decision-making.
A typology of reviews: an analysis of 14 review types and associated methodologies.

BACKGROUND AND OBJECTIVES
The expansion of evidence-based practice across sectors has lead to an increasing variety of review types. However, the diversity of terminology used means that the full potential of these review types may be lost amongst a confusion of indistinct and misapplied terms. The objective of this study is to provide descriptive insight into the most common types of reviews, with illustrative examples from health and health information domains.


METHODS
Following scoping searches, an examination was made of the vocabulary associated with the literature of review and synthesis (literary warrant). A simple analytical framework -- Search, AppraisaL, Synthesis and Analysis (SALSA) -- was used to examine the main review types.


RESULTS
Fourteen review types and associated methodologies were analysed against the SALSA framework, illustrating the inputs and processes of each review type. A description of the key characteristics is given, together with perceived strengths and weaknesses. A limited number of review types are currently utilized within the health information domain.


CONCLUSIONS
Few review types possess prescribed and explicit methodologies and many fall short of being mutually exclusive. Notwithstanding such limitations, this typology provides a valuable reference point for those commissioning, conducting, supporting or interpreting reviews, both within health information and the wider health care domain.
When all you have is a dermatoscope— start looking at the nails

Pigmented and non-pigmented nail alterations are a frequent challenge for dermatologists. A profound knowledge of clinical and dermatoscopic features of nail disorders is crucial because a range of differential diagnoses and even potentially life-threatening diseases are possible underlying causes. Nail matrix melanocytes of unaffected individuals are in a dormant state, and, therefore, fingernails and toenails physiologically are non-pigmented. The formation of continuous, longitudinal pigmented streaks (longitudinal melanonychia) may either be caused by a benign activation of matrix melanocytes (e.g., as a result of trauma, inflammation, or adverse drug reactions) or by a true melanocytic proliferation (e.g., in a nevus or melanoma). In general, non-continuous nail alterations, affecting only limited parts of the nail apparatus, are most frequently of non-melanocytic origin. Important and common differential diagnoses in these cases are subungual hemorrhage or onychomycosis. In addition, foreign bodies, bacterial infections, traumatic injuries, or artificial discolorations of the nail unit may less frequently cause non-continuous nail alterations. Many systemic diseases that may also show involvement of the nails (e.g., psoriasis, atopic dermatitis, lichen planus, alopecia areata) tend to induce alterations in numerous if not all nails of the hands and feet. A similar extensive and generalized alteration of nails has been reported after treatment with a number of systemic drugs, especially antibiotics and cytostatics. Benign or malignant neoplasms that may also affect the nail unit include glomus tumor, Bowen's disease, squamous cell carcinoma, and rare collision tumors. This review aims to assist clinicians in correctly evaluating and diagnosing nail disorders with the help of dermatoscopy.
Use of mobile phones and changes in cognitive function in adolescents.

BACKGROUND
Several studies have investigated the impact of mobile phone exposure on cognitive function in adults. However, children and adolescents are of special interest due to their developing nervous systems.


METHODS
Data were derived from the Australian Mobile Radiofrequency Phone Exposed Users' Study (MoRPhEUS) which comprised a baseline examination of year 7 students during 2005/2006 and a 1-year follow-up. Sociodemographic and exposure data were collected with a questionnaire. Cognitive functions were assessed with a computerised test battery and the Stroop Color-Word test.


RESULTS
236 students participated in both examinations. The proportion of mobile phone owners and the number of voice calls and short message services (SMS) per week increased from baseline to follow-up. Participants with more voice calls and SMS at baseline showed less reductions in response times over the 1-year period in various computerised tasks. Furthermore, those with increased voice calls and SMS exposure over the 1-year period showed changes in response time in a simple reaction and a working memory task. No associations were seen between mobile phone exposure and the Stroop test.


CONCLUSIONS
We have observed that some changes in cognitive function, particularly in response time rather than accuracy, occurred with a latency period of 1 year and that some changes were associated with increased exposure. However, the increased exposure was mainly applied to those who had fewer voice calls and SMS at baseline, suggesting that these changes over time may relate to statistical regression to the mean, and not be the effect of mobile phone exposure.
Option pricing with Mellin transnforms

An option on a stock is an asymmetric contract which entitles the holder to buy (call) or sell (put) a share at a specified price (strike or exercise price) on (European) or before (American) a certain date. The basic background for option pricing is given in [1] and a more specialized t reatment may be found in [2]. For the last three decades, much of the mathematical s tudy in this area has focused on the boundary value problems associated with the Black-Scholes partial differential equation (see [3,4]). As far as we know, there is no closed-form analytical expression for the value 1 of the American put or its associated free boundary. The free boundary is the critical stock price below which it is optimal to exercise the put. Even though numerical techniques based on finite-differences [5], binomial lattices [6], and Monte Carlo methods [7] have been proposed for the pricing problem in one dimension, it seems of some interest to develop alternative methods in a quest for more efficient solutions. A basket option is an option on a collection or basket of stocks. The volatility of the basket is lower than the individual volatilities of the stocks and therefore these options are popular as hedging tools. The pricing of basket options is complicated by the fact tha t the sum of lognormal random variables is not lognormal. Various approximations and numerical methods have been proposed for basket options of the European type (see [8-10]). The pricing problem for an American option on a basket of stocks amounts to solving a multidimensional free boundary problem. For lower dimensions, grid-based