LLukas22/scidocs huggingface dataset:
Randomized clinical trial comparing lumbar percutaneous hydrodiscectomy with lumbar open microdiscectomy for the treatment of lumbar disc protrusions and herniations

OBJECTIVES
Hydrodiscectomy is a new technique used for percutaneous spinal discectomy that employs a high-intensity stream of water for herniated disc ablation and tissue aspiration. No previous clinical study has examined the effects of percutaneous hydrodiscectomy. The aim of this study is to evaluate the outcomes of hydrodiscectomy compared to open microdiscectomy regarding pain, function, satisfaction, complications and recurrence rates.


METHODS
In this randomized clinical trial, patients referred to our tertiary hospital for lumbar back pain were recruited and included in the study if they had disc protrusion or small herniation in only one level, without neurological deficits and with no resolution after six weeks of conservative treatment. One group underwent open microdiscectomy, and the other group underwent percutaneous microdiscectomy via hydrosurgery. Function was evaluated using the Oswestry Disability Index and pain was assessed using a visual analog scale. Evaluations were performed preoperatively, and then during the first week and at one, three, six and twelve months postoperatively. Personal satisfaction was verified. Clinicaltrials.gov: NCT01367860.


RESULTS
During the study period, 20 patients were included in each arm and 39 completed one-year of follow-up (one patient died of unrelated causes). Both groups exhibited equal improvement on the visual analog scale and Oswestry evaluations after treatment, without any significant differences. The improvement in the lumbar visual analog scale score was not significant in the hydrodiscectomy group (p=0.138). The rates of infection, pain, recurrence and satisfaction were similar between the two groups.


CONCLUSION
Percutaneous hydrodiscectomy was demonstrated to be as effective as open microdiscectomy for reducing pain. The rates of complications and recurrence of herniation were similar between groups. Patient satisfaction with the treatment was also similar between groups.
Sustainability in global commodity trade: successful responsible entrepreneurship or fallacious market capture?

Paper presented at 
17th annual International Sustainable Development Research Society Conference 
Earth Institute, Columbia University, New York, USA 
8-10 May 2011.
Contract Representation for Run-time Monitoring and Enforcement

Converting a conventional contract into an electronic equivalent that can be executed and enforced by computers is a challenging task. The difficulties are caused by the ambiguities that the original humanoriented text is likely to contain. The conversion process involves the conversion of the original text into mathematical notation. This paper discusses how standard conventional contracts can be described by means of Finite State Machines (FSMs). This mathematical description helps eliminate ambiguities from the original text before the contract is coded into a computer program. The paper describes how to map the rights and obligations extracted from the clauses of the contract into the states, transition and output functions, and input and output symbols of a FSM. The FSM representation can be used to guarantee that the clauses stipulated in the contract are observed when the contract is executed. The paper describes the middleware required for the enactment of the contract represented as a FSM.
Warrior Model for Human Performance and Injury Prevention: Eagle Tactical Athlete Program (ETAP) Part I.

INTRODUCTION
Physical training for United States military personnel requires a combination of injury prevention and performance optimization to counter unintentional musculoskeletal injuries and maximize warrior capabilities. Determining the most effective activities and tasks to meet these goals requires a systematic, research-based approach that is population specific based on the tasks and demands of the warrior.


OBJECTIVE
We have modified the traditional approach to injury prevention to implement a comprehensive injury prevention and performance optimization research program with the 101st Airborne Division (Air Assault) at Ft. Campbell, KY. This is Part I of two papers that presents the research conducted during the first three steps of the program and includes Injury Surveillance, Task and Demand Analysis, and Predictors of Injury and Optimal Performance.


METHODS
Injury surveillance based on a self-report of injuries was collected on all Soldiers participating in the study. Field-based analyses of the tasks and demands of Soldiers performing typical tasks of 101st Soldiers were performed to develop 101st-specific laboratory testing and to assist with the design of the intervention (Eagle Tactical Athlete Program (ETAP)). Laboratory testing of musculoskeletal, biomechanical, physiological, and nutritional characteristics was performed on Soldiers and benchmarked to triathletes to determine predictors of injury and optimal performance and to assist with the design of ETAP.


RESULTS
Injury surveillance demonstrated that Soldiers of the 101st are at risk for a wide range of preventable unintentional musculoskeletal injuries during physical training, tactical training, and recreational/sports activities. The field-based analyses provided quantitative data and qualitative information essential to guiding 101st specific laboratory testing and intervention design. Overall the laboratory testing revealed that Soldiers of the 101st would benefit from targeted physical training to meet the specific demands of their job and that sub-groups of Soldiers would benefit from targeted injury prevention activities.


CONCLUSIONS
The first three steps of the injury prevention and performance research program revealed that Soldiers of the 101st suffer preventable musculoskeletal injuries, have unique physical demands, and would benefit from targeted training to improve performance and prevent injury.
Adjuvant leuprolide with or without docetaxel in patients with high-risk prostate cancer after radical prostatectomy (TAX-3501): important lessons for future trials.

BACKGROUND
The current trial evaluated 2 common therapies for patients with advanced prostate cancer, docetaxel and hormonal therapy (HT), in the surgical adjuvant setting.


METHODS
TAX-3501 was a randomized, phase 3, adjuvant study post-radical prostatectomy (RP) in high-risk patients with prostate cancer (n=228) comparing 18 months of HT with (CHT) without docetaxel chemotherapy either immediately (I) or deferred (D). High-risk disease was defined as a 5-year freedom-from-disease-progression rate of ≤ 60% as predicted by a post-RP nomogram. Progression-free survival (PFS), including prostate-specific antigen disease recurrence, was the primary endpoint. The authors also assessed the accuracy of the nomogram and analyzed testosterone recovery in 108 patients treated with HT who had at least 1 posttreatment testosterone value.


RESULTS
Between December 2005 and September 2007, 228 patients were randomized between the treatment cohorts. TAX-3501 was terminated prematurely because of enrollment challenges, leaving it underpowered to detect differences in PFS. After a median follow-up of 3.4 years (interquartile range, 2.3-3.8 years), 39 of 228 patients (17%) demonstrated PSA disease progression, and metastatic disease progression occurred in 1 patient. The median time to baseline testosterone recovery after the completion of treatment was prolonged at 487 days (95% confidence interval, 457-546 days). The nomogram's predicted versus observed freedom from disease progression was significantly different for the combination D(HT) and D(CHT) group (P<.00001).


CONCLUSIONS
TAX-3501 illustrated several difficulties involved in conducting postoperative adjuvant systemic trials in men with high-risk prostate cancer: the lack of consensus regarding patient selection and treatment, the need for long follow-up time, nonvalidated intermediate endpoints, evolving standard approaches, and the need for long-term research support. Except for selected patients at very high-risk of disease recurrence and death, surgical adjuvant trials in patients with prostate cancer may not be feasible.
Knowledge of diagnosis, treatment history, and risk of late effects among childhood cancer survivors and parents: The impact of a survivorship clinic.

BACKGROUND
Childhood cancer survivors are at risk for treatment-related adverse health outcomes, known as late effects. Through matched and longitudinal cohorts, we assessed the impact of survivorship care on patient and parent knowledge of treatment history and associated health risks.


PROCEDURE
Childhood cancer survivors were recruited from a single-institution survivorship clinic and matched with survivors receiving routine follow-up care (controls) on diagnosis, age, and time off therapy. One hundred seventy-four participants completed telephone interviews assessing knowledge of diagnosis, treatment history, and risk of late effects. Additionally, 48 new survivorship patients were followed longitudinally with serial interviews for 18 months.


RESULTS
In the case-control study, survivorship participants were more likely than controls to correctly report their diagnosis (98% vs. 90%, P = 0.039) and indicate a previous discussion of risk of late effects (99% vs. 62%, P<0.0001). Compared to controls, survivorship participants were 13% more sensitive reporting chemotherapeutics (95%CI 2.8-23.7%, P = 0.013) and 12% more sensitive reporting late effect risk (95%CI 7.3-16.6%, P<0.0001). In the longitudinal cohort, participants were 7% more sensitive reporting chemotherapeutics (95%CI 5.4-10.8%, P < 0.001) and 9% more sensitive reporting late effect risk (95%CI 5.6-23.8%, P<0.001) at 3 months compared to baseline. In regression analysis, baseline knowledge correlated with subsequent interview performance, and time since survivorship visit correlated with decreased knowledge of late effects, but not diagnosis or treatment history.


CONCLUSIONS
Survivorship care was associated with increased knowledge of diagnosis, treatment history, and risk of late effects in both cohorts. Knowledge of late effects decreases with time, suggesting the need for additional educational strategies.
Legal theory and the humanities

Contents: Introduction. Part I Imagination, Emotion and the Particular: Empathy, legal storytelling, and the rule of law: new words, old wounds?, Toni M. Massaro Poets as judges: judicial rhetoric and the literary imagination, Martha C. Nussbaum The echo of a sentimental jurisprudence, Ian Ward. Part II Voice, Perspective and Community: The judicial opinion and the poem: ways of reading, ways of life, James Boyd White Law as rhetoric, rhetoric as law: the arts of cultural and communal life, James Boyd White The judicial opinion as literary genre, Robert A. Ferguson Narrative transactions - does the law need a narratology?, Peter Brooks Ghosts of law and humanities (past, present, future), Marett Leiboff. Part III Image, Vision and Pattern: The aesthetics of American law, Pierre Schlag Tele-tribunals: anatomy of a medium, Cornelia Vismann Precrime never pays! 'Law and economics' in Minority Report, William P. MacNeil Visiocracy: on the futures of the fingerpost, Peter Goodrich. Part IV Space, Music and Performance: Law, music, and other performing arts, Sanford Levinson and J.M. Balkin Theatre of deferral: the image of the law and the architecture of the Inns of Court, David Evans Prelude: senses and symbols in aesthetic experience, Desmond Manderson Legal performance good and bad, Julie Stone Peters Screening law, Peter Goodrich. Index.
Collaborative expression representation using peak expression and intra class variation face images for practical subject-independent emotion recognition in videos

This paper proposes a facial expression recognition (FER) method in videos. The proposed method automatically selects the peak expression face from a video sequence using closeness of the face to the neutral expression. The severely non-frontal faces and poorly aligned faces are discarded in advance to eliminate their negative effects on the peak expression face selection and FER. To reduce the effect of the facial identity in the feature extraction, we compute difference information between the peak expression face and its intra class variation (ICV) face. An ICV face is generated by combining the training faces of an expression class and looks similar to the peak expression face in identity. Because the difference information is defined as the distances of locally pooled texture features between the two faces, the feature extraction is robust to face rotation and mis-alignment. Results show that the proposed method is practical with videos containing spontaneous facial expressions and pose variations. & 2016 Elsevier Ltd. All rights reserved.
The Impact of Thrombocytopenia on Outcome in Patients with Acute Coronary Syndromes: A Single Center Retrospective Study

BACKGROUND
In acute coronary syndromes (ACS), treated by combined antithrombotic therapy and percutaneous coronary interventions (PCI), thrombocytopenia may occur. Our aim was to evaluate predictors and the impact of thrombocytopenia on mortality in high-risk ACS patients.


METHODS
We retrospectively evaluated high-risk ACS patients. Thrombocytopenia was defined as platelet count <140.000/mL or a drop in platelet count of >50% during in-hospital stay. We compared demographic, laboratory, clinical, and mortality data between nonthrombocytopenic and thrombocytopenic ACS patients and evaluated independent predictors of thrombocytopenia.


RESULTS
In 371 ACS patients, thrombocytopenia was observed in 21.3%. Thrombocytopenic patients were significantly older and, less likely treated by PCIs (72.1% versus 89.7%, p < 0.001) and combined antithrombotic therapy, with increased incidence of in-hospital complications and the use of additional treatments, but with increased mortality at 30 days (27.8% versus 10.2%, p < 0.001) and 6 months (35.4% versus 13.6%, p < 0.001) when compared to nonthrombocytopenic patients. The use of antibiotics, transfusions, insertion of intra-aortic balloon pump (IABP), and prior stroke independently predicted thrombocytopenia.


CONCLUSIONS
Thrombocytopenia, observed in about 20% of high-risk ACS patients, was associated significantly with in-hospital complications and mortality. Predictors of thrombocytopenia were the use of antibiotics, transfusions, insertion of IABP, and prior stroke.
The effects of baseline heart rate recovery normality and exercise training protocol on heart rate recovery in patients with heart failure

OBJECTIVE
It is unclear which exercise training protocol yields superior heart rate recovery (HRR) improvement in heart failure (HF) patients. Whether baseline HRR normality plays a role in the improvement is unknown. We hypothesized that an exercise training protocol and baseline HRR normality would be factors in altering HRR in HF patients.


METHODS
In this prospective, randomized, controlled and 3 group parallel study, 41 stable HF patients were randomly assigned to 3-times-weekly training sessions for 12 weeks, consisting of i) 30 minutes of interval training (IT) (n=17, 63.7±8.8 years old) versus ii) 30 minutes of continuous training (CT) (n=13, 59.6±6.8 years old) versus iii) no training (CON) (n=11, 60.6±9.9 years old). Each patient had cardiopulmonary exercise testing before and after the training program. Maximum heart rates attained during the test and heart rates at 1 and 2 min (HRR1 and HRR2) during the recovery phase were recorded. Paired samples t-test or Wilcoxon signed-rank test was used for comparisons before and after training. One-way ANOVA or Kruskal-Wallis variance analysis was used for comparisons among groups.


RESULTS
HRR1 was unchanged after training. HRR2 improved in the IT group after training, and post-training HRR2 values were significantly faster in the IT group than in controls. Both HRR1 and HRR2 was significantly faster, irrespective of exercise protocol in patients with abnormal baseline values after training.


CONCLUSION
HRR1 did not improve after training. HRR2 improved only in the IT group. Both HRRs in patients with abnormal baseline values improved after both exercise protocols. IT might be superior to CT in improving HRR2. Baseline HRR might play a role in its response to exercise.
Normal forms for binary relations

We consider the representable equational theory of binary relations, in a language expressing composition, converse, and lattice operations. By working directly with a presentation of relation expressions as graphs we are able to define a notion of reduction which is confluent and strongly normalizing and induces a notion of computable normal form for terms. This notion of reduction thus leads to a computational interpretation of the representable theory.
Formation of metastable solid solutions by mechanical alloying of immiscible Ag and Bi

Abstract This work investigates the effects of the Vickers micro-hardness of Ag powders on the alloying process undergone by Ag 90 Bi 10 powder mixtures submitted to ball milling. The transformation kinetics has been studied by quantitative X-ray diffraction. The experimental findings indicate that Bi gradually dissolves into Ag, finally forming a crystalline solid solution in which thermodynamic solubility limits are largely exceeded. It is shown that the rate of Bi dissolution, and the solubility degree, decrease as the Vickers micro-hardness of Ag powders increases.
Aurantiamide acetate from baphicacanthus cusia root exhibits anti-inflammatory and anti-viral effects via inhibition of the NF-κB signaling pathway in Influenza A virus-infected cells.

ETHNOPHARMACOLOGICAL RELEVANCE
Baphicacanthus cusia root also names "Nan Ban Lan Gen" has been traditionally used to prevent and treat influenza A virus infections. Here, we identified a peptide derivative, aurantiamide acetate (compound E17), as an active compound in extracts of B. cusia root. Although studies have shown that aurantiamide acetate possesses antioxidant and anti-inflammatory properties, the effects and mechanism by which it functions as an anti-viral or as an anti-inflammatory during influenza virus infection are poorly defined. Here we investigated the anti-viral activity and possible mechanism of compound E17 against influenza virus infection.


MATERIALS AND METHODS
The anti-viral activity of compound E17 against Influenza A virus (IAV) was determined using the cytopathic effect (CPE) inhibition assay. Viruses were titrated on Madin-Darby canine kidney (MDCK) cells by plaque assays. Ribonucleoprotein (RNP) luciferase reporter assay was further conducted to investigate the effect of compound E17 on the activity of the viral polymerase complex. HEK293T cells with a stably transfected NF-κB luciferase reporter plasmid were employed to examine the activity of compound E17 on NF-κB activation. Activation of the host signaling pathway induced by IAV infection in the absence or presence of compound E17 was assessed by western blotting. The effect of compound E17 on IAV-induced expression of pro-inflammatory cytokines was measured by real-time quantitative PCR and Luminex assays.


RESULTS
Compound E17 exerted an inhibitory effect on IAV replication in MDCK cells but had no effect on avian IAV and influenza B virus. Treatment with compound E17 resulted in a reduction of RNP activity and virus titers. Compound E17 treatment inhibited the transcriptional activity of NF-κB in a NF-κB luciferase reporter stable HEK293 cell after stimulation with TNF-α. Furthermore, compound E17 blocked the activation of the NF-κB signaling pathway and decreased mRNA expression levels of pro-inflammatory genes in infected cells. Compound E17 also suppressed the production of IL-6, TNF-α, IL-8, IP-10 and RANTES from IAV-infected lung epithelial (A549) cells.


CONCLUSIONS
These results indicate that compound E17 isolated from B. cusia root has potent anti-viral and anti-inflammatory effects on IAV-infected cells via inhibition of the NF-κB pathway. Therefore, compound E17 could be a potential therapeutic agent for the treatment of influenza.
Feet movement in desktop 3D interaction

In this paper we present an exploratory work on the use of foot movements to support fundamental 3D interaction tasks. Depth cameras such as the Microsoft Kinect are now able to track users' motion unobtrusively, making it possible to draw on the spatial context of gestures and movements to control 3D UIs. Whereas multitouch and mid-air hand gestures have been explored extensively for this purpose, little work has looked at how the same can be accomplished with the feet. We describe the interaction space of foot movements in a seated position and propose applications for such techniques in three-dimensional navigation, selection, manipulation and system control tasks in a 3D modelling context. We explore these applications in a user study and discuss the advantages and disadvantages of this modality for 3D UIs.
Supergravity computations without gravity complications

United States. Dept. of Energy. Office of High Energy and Nuclear Physics (Contract No. DE-AC02-05CH11231)
Use of a gesture user interface as a touchless image navigation system in dental surgery: Case series report

PURPOSE
The purposes of this study were to develop a workstation computer that allowed intraoperative touchless control of diagnostic and surgical images by a surgeon, and to report the preliminary experience with the use of the system in a series of cases in which dental surgery was performed.


MATERIALS AND METHODS
A custom workstation with a new motion sensing input device (Leap Motion) was set up in order to use a natural user interface (NUI) to manipulate the imaging software by hand gestures. The system allowed intraoperative touchless control of the surgical images.


RESULTS
For the first time in the literature, an NUI system was used for a pilot study during 11 dental surgery procedures including tooth extractions, dental implant placements, and guided bone regeneration. No complications were reported. The system performed very well and was very useful.


CONCLUSION
The proposed system fulfilled the objective of providing touchless access and control of the system of images and a three-dimensional surgical plan, thus allowing the maintenance of sterile conditions. The interaction between surgical staff, under sterile conditions, and computer equipment has been a key issue. The solution with an NUI with touchless control of the images seems to be closer to an ideal. The cost of the sensor system is quite low; this could facilitate its incorporation into the practice of routine dental surgery. This technology has enormous potential in dental surgery and other healthcare specialties.
Social neuroscience: challenges and opportunities in the study of complex behavior.

Social species are so characterized because they form organizations that extend beyond the individual. The goal of social neuroscience is to investigate the biological mechanisms that underlie these social structures, processes, and behavior and the influences between social and neural structures and processes. Such an endeavor is challenging because it necessitates the integration of multiple levels. Mapping across systems and levels (from genome to social groups and cultures) requires interdisciplinary expertise, comparative studies, innovative methods, and integrative conceptual analysis. Examples of how social neuroscience is contributing to our understanding of the functions of the brain and nervous system are described, and societal implications of social neuroscience are considered.