LLukas22/scidocs huggingface dataset:
Insulin-like growth factor I stimulates motility in human neuroblastoma cells

Motility is an important process that contributes to cancer cell spread. Growth factors are key regulators of motility in many cell types. Insulin-like growth factor I (IGF-I) causes SH-SY5Y human neuroblastoma cells to undergo dynamic morphological changes, leading to the extension of lamellipodia. IGF-I stimulated lamellipodia extension requires signaling through both phosphatidylinositol 3-kinase (PI3-K) and MAP kinase pathways. IGF-I, over a period of hours, stimulates SH-SY5Y and SHEP neuroblastoma cells to become more motile. While SH-SY5Y and SHEP cells use different insulin receptor substrate (IRS) isoforms to transduce signals from the IGF-I receptor, IGF-I has the same relative effect on the motility of both cell lines. Blocking the PI3-K and MAP kinase pathways attenuates the ability of IGF-I to increase motility. Overexpression of PTEN also attenuates IGF-I mediated motility. These results delineate some of the proximal events in the signaling mechanism utilized by IGF-I to stimulate cell motility.
No perinatal HIV-1 transmission from women with effective antiretroviral therapy starting before conception.

BACKGROUND
The efficacy of preventing perinatal transmission (PT) of human immunodeficiency virus type 1 (HIV-1) depends on both viral load (VL) and treatment duration. The objective of this study was to determine whether initiating highly active antiretroviral therapy (ART) before conception has the potential to eliminate PT.


METHODS
A total of 8075 HIV-infected mother/infant pairs included from 2000 to 2011 in the national prospective multicenter French Perinatal Cohort (ANRS-EPF) received ART, delivered live-born children with determined HIV infection status, and did not breastfeed. PT was analyzed according to maternal VL at delivery and timing of ART initiation.


RESULTS
The overall rate of PT was 0.7% (56 of 8075). No transmission occurred among 2651 infants born to women who were receiving ART before conception, continued ART throughout the pregnancy, and delivered with a plasma VL <50 copies/mL (upper 95% confidence interval [CI], 0.1%). VL and timing of ART initiation were independently associated with PT in logistic regression. Regardless of VL, the PT rate increased from 0.2% (6 of 3505) for women starting ART before conception to 0.4% (3 of 709), 0.9% (24 of 2810), and 2.2% (23 of 1051) for those starting during the first, second, or third trimester (P < .001). Regardless of when ART was initiated, the PT rate was higher for women with VLs of 50-400 copies/mL near delivery than for those with <50 copies/mL (adjusted odds ratio, 4.0; 95% CI, 1.9-8.2).


CONCLUSIONS
Perinatal HIV-1 transmission is virtually zero in mothers who start ART before conception and maintain suppression of plasma VL.
Protocols and architectures for wireless sensor networks

Protocols this text provides a very helpful especially for students teachers. I was like new provides, academic researchers shows. All topics related to be comfortable with excellent comprehensive reference section is on communications issues. Provides academic researchers he has, published numerous papers and applications free. This book of wireless sensor networks there is on ad hoc networks. Shows which circumstances they generally walk through of references.
Using Rubrics to Collect Evidence for Decision-Making: What do Librarians Need to Learn?

Objective Every day librarians make decisions that impact on the provision of library products and services. To formulate good decisions librarians must be equipped with reliable and valid data. Unfortunately, many library processes generate vast quantities of unwieldy information that is ill suited for the evidence based decision-making (EBDM) practices librarians strive to employ. Librarians require tools to facilitate the translation of unmanageable facts and figures into data that can be used to support decision-making. One such tool is a rubric. Rubrics provide benefits to librarians seeking to use EBDM strategies. This study examined librarians' abilities to use rubrics as a decision facilitation tool, explored barriers that might prevent effective rubric usage, and suggested training topics that address potential barriers. Methods The data for the study came from student responses to open-ended questions embedded in an online information literacy tutorial, LOBO, used by first-year students in English 101 at North Carolina State University (NCSU). Fifteen academic librarians, five instructors, and five students applied rubrics to transform students' textual responses into quantitative data; this data was statistically analyzed for reliability and validity using Cohen's Kappa. Participant comment sheets were also examined to reveal potential hurdles to effective rubric use.
Linguistic Regularities in Continuous Space Word Representations

• Neural network language model and distributed representation for words (Vector representation) • Capture syntactic and remantic regularities in language • Outperform state-of-the-art
Actor-Action Semantic Segmentation with Region Masks

In this paper, we study the actor-action semantic segmentation problem, which requires joint labeling of both actor and action categories in video frames. One major challenge for this task is that when an actor performs an action, different body parts of the actor provide different types of cues for the action category and may receive inconsistent action labeling when they are labeled independently. To address this issue, we propose an end-to-end region-based actor-action segmentation approach which relies on region masks from an instance segmentation algorithm. Our main novelty is to avoid labeling pixels in a region mask independently instead we assign a single action label to these pixels to achieve consistent action labeling. When a pixel belongs to multiple region masks, max pooling is applied to resolve labeling conflicts. Our approach uses a two-stream network as the front-end (which learns features capturing both appearance and motion information), and uses two region-based segmentation networks as the back-end (which takes the fused features from the two-stream network as the input and predicts actor-action labeling). Experiments on the A2D dataset demonstrate that both the region-based segmentation strategy and the fused features from the two-stream network contribute to the performance improvements. The proposed approach outperforms the state-of-the-art results by more than 8% in mean class accuracy, and more than 5% in mean class IOU, which validates its effectiveness. c © 2018. The copyright of this document resides with its authors. It may be distributed unchanged freely in print or electronic forms. The research was partially supported by the ST Engineering NTU Corporate Lab through the NRF corporate lab@university scheme. The research was partially supported by start-up funds of University at Buffalo. ar X iv :1 80 7. 08 43 0v 1 [ cs .C V ] 2 3 Ju l 2 01 8 2 DANG ET AL.: ACTOR-ACTION SEMANTIC SEGMENTATION WITH REGION MASKS bird-flying babywalking birdnone bird-flying
Leaner Model Ontology and leaner Model Agent

In this paper we describe the learner model ontology and learner model agent in a multi-agent architecture of learning support systems. The learner model ontology facilitates 1) sharable specification of the functionalities of learner model agent; 2) fluent communication between the learner model agent and other agents. The example of a learner model ontology and learner model agent shows that with the help of ontology, a standard for sharable and reusable agents in learning support systems may be established. The goal of the research presented in this paper is to exemplify the benefit of the learner model ontology through the development of an ontology-based learner model agent and the exchange of information between the learner model agent and other agents.
A prospective randomized controlled trial of sclerotherapy vs ligation in the prophylactic treatment of high-risk esophageal varices

Background: Endoscopic ligation (EVL) and endoscopic sclerotherapy (EIS) are both effective in the treatment of bleeding esophageal varices, but the efficacy of the two techniques in the prophylaxis of first variceal bleeding has not been investigated. The aim of this study was to investigate the frequency of first variceal bleeding, the recurrence of varices, and survival after treatment with the two techniques, as compared to a nontreated control group. Methods: A total of 157 patients with liver cirrhosis and advanced esophageal varices with no previous history of upper gastrointestinal bleeding were randomly assigned to either an EIS group (n= 55), an EVL group (n= 52), or a nontreated control group (n= 50). After the eradication of esophageal varices in the EIS and in EVL groups and in all control patients, the endoscopic examination was performed at 3-month intervals. Results: There were no significant differences between EIS and EVL in the eradication rate of esophageal varices (85% in the EIS group versus 81% in the EVL group). The mean number of sessions required to obtain eradication was lower in the EVL group than in the EIS group (4.8 ± 1.8 versus 6.2 ± 2.0; p= 0.0003), but the recurrence of esophageal varices was higher in the EVL group (31% versus 11%; p= 0.01). Total mortality was significantly lower in the EIS patients than in the controls (20% versus 38%; p= 0.04). It was also lower, but not significantly, in the EVL patients than in the controls (23% versus 38%; p= 0.10). A significant decrease in variceal bleeding was observed both in sclerotherapy cases (20%) and controls (54%; p= 0.0005) and in ligation cases and controls (29%; p= 0.01). No significant difference in bleeding episodes was observed between the sclerotherapy and ligation cases (p= 0.29). No serious complications were observed either in the EIS or EVL groups. Conclusions: EIS and EVL are similarly effective in the prevention of first variceal bleeding. The choice between EIS and EVL depends on the skill of the endoscopic unit. For highly experienced surgeons facing no complications, sclerotherapy seems to be preferable; for all others, it is technically easier to perform ligation.
Design of a cutaneous fingertip display for improving haptic exploration of virtual objects

A new prototype of portable device for haptic interaction with virtual environments is presented. It is a lightweight interface for the fingertips, designed for providing cutaneous feedback and displaying the contact ¿ non contact transition in highly immersive virtual environments. The second version of the interface features a force sensor for controlling the force on the fingertip during contact, assuring a better haptic feedback. In this paper the kinematics, the mechanical design and the improved control system are described. The device has been mounted on a kinesthetic haptic interface which tracks its position: in this configuration, the overall system can provide both cutaneous and kinesthetic feedback and improve the fidelity of the haptic interaction. Finally the performance of the cutaneous device in a task of contour following has been evaluated.
Prospective validation study of transorbital Doppler ultrasound imaging for the detection of transient cerebral microemboli.

BACKGROUND
Transient cerebral microemboli are independent biomarkers of early risk of ischaemic stroke in acute carotid syndromes. Transcranial Doppler imaging (TCD) through the temporal bone is the standard method for detection of cerebral microemboli, but an acoustic temporal bone window for TCD is not available in around one in seven patients. Transorbital Doppler imaging (TOD) has been used when TCD is not possible. The aim of this study was to validate the use of TOD against TCD for detecting cerebral microemboli.


METHODS
The study included patients undergoing elective carotid endarterectomy; all had confirmed temporal and orbital acoustic windows. Subjects gave written informed consent to postoperative TCD and TOD monitoring, which was performed simultaneously for 30 min by two vascular scientists.


RESULTS
The study included 100 patients (mean(s.e.m.) age 72(1) years; 65 men). Microemboli were detected by one or both methods in 40·0 per cent of patients: by TOD and TCD in 24 patients, by TOD alone in ten and by TCD alone in six. For detecting microemboli, TOD had a sensitivity of 80·0 per cent, specificity of 86·1 per cent, positive predictive value of 71·6 per cent and negative predictive value of 91·2 per cent. Bland-Altman analysis revealed no significant bias (bias 0·11 (95 per cent c.i. -0·52 to 0·74) microemboli; P = 0·810) with upper and lower limits of agreement of +6 and -6 microemboli.


CONCLUSION
TOD appears a valid alternative to TCD for detecting microembolic signals in patients with no suitable temporal acoustic window.
Prognosis for the recovery of surgeons from chemical dependency: a 5-year outcome study.

HYPOTHESIS
Rates of relapse, monitoring contract completion, and return to medical practice may differ between surgeons and nonsurgeons being monitored for diagnosed substance use disorders.


DESIGN
Retrospective 5-year longitudinal cohort study.


SETTING
A sample of 16 state physician health programs in the United States.


PARTICIPANTS
Nine hundred four physicians who underwent treatment for a substance use disorder and were consecutively admitted to 1 of 16 state physician health programs between September 1, 1995, and September 1, 2001. The study analyzed a subset of data comparing 144 surgeons with 636 nonsurgeons.


MAIN OUTCOME MEASURES
Rates of continued drug and alcohol misuse (relapse), monitoring contract completion, and return to medical practice at 5 years.


RESULTS
Surgeons were significantly more likely than nonsurgeons to enroll in a physician health program because of alcohol-related problems (odds ratio, 1.9; 95% CI, 1.3-2.7; P = .001) and were less likely to enroll because of opioid use (odds ratio, 0.5; 95% CI, 0.3-0.8, P = .002). Surgeons were neither more nor less likely than nonsurgeons to have a positive drug test result, complete or fail to complete the monitoring contract, or extend the monitoring period beyond the original 5 years specified in their agreements. Fewer surgeons than nonsurgeons were licensed and practicing medicine at the conclusion of the monitoring period, although this difference was not statistically significant.


CONCLUSIONS
Surgeons in this study had positive outcomes similar to those of nonsurgeons. However, further research is necessary to conclude whether surgeons are less likely than their nonsurgeon peers to successfully return to medical practice following chemical dependency treatment.
Oral Piercing and Oral Diseases: A Short Time Retrospective Study

Body piercing indicates the puncturing of a part of the body in which jewelry may be worn. In recent years, oral piercing is increasingly popular especially among young people. Body piercing has to be considered as a surgical procedure to all intents and purposes and, as such, has to be performed only by qualified personnel able to assure high standards of professionalism in facilities subject to sanitary inspections.The aim of the present work is to verify what risks patients may be exposed to and what complications may occur after a healthcare professional performs oral piercing.Our retrospective study includes 108 patients (74 males and 34 females) aged between 14 and 39 years, who had oral piercing done 12±4 months earlier. All the patients underwent clinical examination to reveal the possible presence of late complications. After piercing, none of the 108 patients developed widespread complications.Although all patients said they had followed the piercers' instructions, 96% of them reported postoperative local complications such as bleeding within 12 hours of piercing (90%), perilesional edema for 3±2 days after piercing surgery (80%), and persistent mucosal atrophy (70%).
Five-year outcomes in patients with left main disease treated with either percutaneous coronary intervention or coronary artery bypass grafting in the synergy between percutaneous coronary intervention with taxus and cardiac surgery trial.

BACKGROUND
Current guidelines recommend coronary artery bypass graft surgery (CABG) when treating significant de novo left main coronary artery (LM) stenosis; however, percutaneous coronary intervention (PCI) has a class IIa indication for unprotected LM disease in selected patients. This analysis compares 5-year clinical outcomes in PCI- and CABG-treated LM patients in the Synergy Between PCI With Taxus and Cardiac Surgery (SYNTAX) trial, the largest trial in this group to date.


METHODS AND RESULTS
The SYNTAX trial randomly assigned 1800 patients with LM or 3-vessel disease to receive either PCI (with TAXUS Express paclitaxel-eluting stents) or CABG. The unprotected LM cohort (N=705) was predefined and powered. Major adverse cardiac and cerebrovascular event rates at 5 years was 36.9% in PCI patients and 31.0% in CABG patients (hazard ratio, 1.23 [95% confidence interval, 0.95-1.59]; P=0.12). Mortality rate was 12.8% and 14.6% in PCI and CABG patients, respectively (hazard ratio, 0.88 [95% confidence interval, 0.58-1.32]; P=0.53). Stroke was significantly increased in the CABG group (PCI 1.5% versus CABG 4.3%; hazard ratio, 0.33 [95% confidence interval, 0.12-0.92]; P=0.03) and repeat revascularization in the PCI arm (26.7% versus 15.5%; hazard ratio, 1.82 [95% confidence interval, 1.28-2.57]; P<0.01). Major adverse cardiac and cerebrovascular events were similar between arms in patients with low/intermediate SYNTAX scores but significantly increased in PCI patients with high scores (≥33).


CONCLUSIONS
At 5 years, no difference in overall major adverse cardiac and cerebrovascular events was found between treatment groups. PCI-treated patients had a lower stroke but a higher revascularization rate versus CABG. These results suggest that both treatments are valid options for LM patients. The extent of disease should accounted for when choosing between surgery and PCI, because patients with high SYNTAX scores seem to benefit more from surgery compared with those in the lower tertiles.


CLINICAL TRIAL REGISTRATION URL
http://www.clinicaltrials.gov. Unique identifier: NCT00114972.
Repeated adeno-associated virus serotype 2 aerosol-mediated cystic fibrosis transmembrane regulator gene transfer to the lungs of patients with cystic fibrosis: a multicenter, double-blind, placebo-controlled trial.

STUDY OBJECTIVES
The primary objective was to determine the safety and tolerability of repeated doses of aerosolized adeno-associated serotype 2 vector containing cystic fibrosis transmembrane conductance regulator (CFTR) complementary DNA (cDNA) [tgAAVCF], an adeno-associated virus (AAV) vector encoding the complete human CFTR cDNA. Secondary objectives included evaluation of pulmonary function assessed by spirometry, lung abnormalities by high-resolution CT (HRCT), airway cytokines, vector shedding, serum neutralizing antibody to AAV serotype 2 (AAV2), and gene transfer and expression in a subset of subjects undergoing bronchoscopy with bronchial brushings.


DESIGN
Randomized, double-blind, placebo-controlled, phase II trial.


SETTING
Eight cystic fibrosis (CF) centers in the United States.


SUBJECTS
CF patients with mild lung disease, defined as FEV(1) > or =60% predicted.


INTERVENTIONS
Subjects were randomized to inhale three aerosolized doses of 1 x 10(13) deoxyribonuclease-resistant particles of tgAAVCF or matching placebo at 30-day intervals using the Pari LC Plus nebulizer (PARI; Richmond, VA).


MEASUREMENTS AND RESULTS
Of 42 subjects randomized, 20 subjects received at least one dose of tgAAVCF and 17 subjects received placebo. No difference in the pattern of adverse events or laboratory abnormalities was noted between the two treatment groups. Improvements in induced-sputum interleukin-8 (p = 0.03) and FEV(1) (p = 0.04) were observed at day 14 and day 30, respectively, in the group receiving tgAAVCF when compared to those receiving placebo. No significant differences in HRCT scans were noted. Vector shedding in sputum was observed at low levels up to 90 days after the third dose of vector. All subjects receiving tgAAVCF exhibited an increase (by at least fourfold) in serum AAV2-neutralizing antibodies and detectable levels in BAL fluid from five of six treated subjects undergoing BAL. Gene transfer but not gene expression was detected in a subset of six tgAAVCF subjects who underwent bronchoscopy.


CONCLUSIONS
Repeat doses of aerosolized tgAAVCF were safe and well tolerated, and resulted in encouraging trends in improvement in pulmonary function in patients with CF and mild lung disease.
Impact of the condolence letter on the experience of bereaved families after a death in intensive care: study protocol for a randomized controlled trial.

BACKGROUND
As intensive care mortality is high, end of life is a subject of major concern for intensivists. In this context, relatives are particularly vulnerable and prone to post-ICU syndrome, in the form of high levels of anxiety, depression, post-traumatic stress, and complicated grief. Grieving families suffer from a feeling of abandonment and evoke the need to get back in touch with the team to ask questions and remove doubts, but very few actually do. Aiding families during the grieving process is an important aspect of palliative care. A condolence letter represents an opportunity to recognize the pain of the family member and the strong tie that linked the family member to the ICU team, and to offer additional information if necessary. The goal of the study is to measure the impact of the condolence letter on the experience of bereaved families after a death in the ICU. Our hypothesis is that a post-death follow-up in the form of a condolence letter sent by the ICU physician who was in charge of the patient may help to reduce the risks of presenting symptoms of anxiety/depression, post-traumatic stress, and complicated grief.


METHODS/DESIGN
This is a randomized, controlled, multicenter study. Research will compare two groups of bereaved family members: one group that does not receive a condolence letter (control) and one group that receives a condolence letter 15 days after the death (intervention). Each of the 22 participating centers will include 12 relatives. Participating relatives will be followed up by phone with a call at 1 month and one at 6 months to complete questionnaires, permitting evaluation of post-ICU burden. The main outcome is anxiety and depression measured at 1 month. Other outcomes include evaluation of quality of dying and death, post-traumatic stress, and complicated grief.


DISCUSSION
This study will allow us to assess if sending a condolence letter can reduce the risks of presenting symptoms of anxiety and depression, complicated grief, and symptoms of post-traumatic stress disorder after the death of a loved one in the ICU.


TRIAL REGISTRATION



CLINICAL TRIALS REGISTRATION NUMBER
Clinicaltrials.gov NCT02325297 (23 December 2014).
Application of Neural Networks to Stock Market Prediction

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