LLukas22/scidocs huggingface dataset:
Pharmacist's identity development within multidisciplinary primary health care teams in Ontario; qualitative results from the IMPACT project.

BACKGROUND
Multidisciplinary team development generates changes in roles, responsibilities, and identities of individual health care providers. The Integrating Family Medicine and Pharmacy to Advance Primary Care Therapeutics (IMPACT) project introduced pharmacists into family practice teams across Ontario, Canada, to provide medication assessments, drug information, and academic detailing and to develop office system enhancements to improve drug therapy.


OBJECTIVE
To analyze pharmacists' narrative accounts during early integration to study identity development within emerging team-based care.


METHOD
Qualitative design using 63 pharmacist narrative reports of pharmacists' experiences over a 9-month integration period. Four independent researchers with varied professional backgrounds used immersion and crystallization to identify codes and iterative grounded theory to determine and debate process and content themes relevant to identity development.


RESULTS
The pharmacists' narratives spoke of the daily experiences of integrating into a family practice setting: feeling valued and contributing concretely to patient care; feeling underutilized; feeling like a nuisance, or feeling as though working too slowly. Pharmacist mentors helped deal with uncertainty and complexity of care. Pharmacists perceived that complementary clinical contributions enhanced their status with physicians and motivated pharmacists to take on new responsibilities. Changes in perspective, clinic-relevant skill development, and a new sense of professionalism signaled an emerging pharmacist family practice identity.


CONCLUSION
Pharmacists found that the integration into team-based primary health care provided both challenges and fresh opportunities. Pharmacists' professional identities evolved in relation to valued role models, emerging practice-level opportunities, and their patient-related contributions.
Principles of plasma discharges and materials processing

p. 19, Fig. 1.14: Add labels (a)–(d). p. 22, line 4: “T = 0.026 V” should be “T = 0.026 V”. p. 29, line 6: “axvdvx/dt” should be “ax = dvx/dt”. p. 32, Eq. (2.3.14): remove “.” (period) from the equation. p. 75, line 3: “(3.4.7)” should be “(3.4.6)”. p. 143, Eq. (5.2.38): “ ν 2 iz D2 ” should be “ νiz D ”. p. 144, 2nd line from the last: “to obtain” should be “obtain”. p. 147, 1st line after Heuristic Solutions: “(5.3.23)” should be “(5.3.7)”. p. 159, line 5: “Fig. 12.10” should be “Fig. 12.12”. p. 170, Eq. (6.2.11): “ dui dx ” should be “n dui dx ”. p. 174, 3rd line from the last: “t = 5 × 10−8 s” should be “t = 4 × 10−8 s”. p. 177, line 12: “E = dΦ/dx” should be “E = −dΦ/dx”. p. 195, 5th line of 2nd paragraph: “all to easy” should be “all too easy”. p. 197, Eq. (6.6.36): “[1 + (VB−Φp) 1/2 Te ]” should be “[1 + (VB−Φp) Te ] ”. p. 221, line 4: add a space between “gas,” and “to obtain”. p. 221, 3rd line after Eq. (7.3.31): “μ j = μj” should be “μj = μ – ◦ j”. p. 224, 1st two lines after the table: “(7.4.9)” and “(7.4.10)” should be exchanged. p. 244, line 11: “atom” should be “molecule”. p. 258, 7th line from the last: “state 2” should be “state 3”. p. 269, 3rd and 4th reactions: “AB∗” should be “AB”. p. 302, top of the page: add the line “∼ aeff . An electron with energy Ee can”. p. 314, line 2: “given by” should be “given by the equation below”. p. 346, equation after Eq. (10.3.20): “TineE + Tin−E” should be “neE/Ti + n−E/Ti”. p. 346, line 8: “(10.3.14)” should be “(10.3.21)”. p. 350, 4th line after Eq. (10.3.37): “(10.3.26)” should be “(10.3.36)”.
An interactive platform to guide catheter ablation in human persistent atrial fibrillation using dominant frequency, organization and phase mapping

BACKGROUND AND OBJECTIVE
Optimal targets for persistent atrial fibrillation (persAF) ablation are still debated. Atrial regions hosting high dominant frequency (HDF) are believed to participate in the initiation and maintenance of persAF and hence are potential targets for ablation, while rotor ablation has shown promising initial results. Currently, no commercially available system offers the capability to automatically identify both these phenomena. This paper describes an integrated 3D software platform combining the mapping of both frequency spectrum and phase from atrial electrograms (AEGs) to help guide persAF ablation in clinical cardiac electrophysiological studies.


METHODS
30s of 2048 non-contact AEGs (EnSite Array, St. Jude Medical) were collected and analyzed per patient. After QRST removal, the AEGs were divided into 4s windows with a 50% overlap. Fast Fourier transform was used for DF identification. HDF areas were identified as the maximum DF to 0.25Hz below that, and their centers of gravity (CGs) were used to track their spatiotemporal movement. Spectral organization measurements were estimated. Hilbert transform was used to calculate instantaneous phase.


RESULTS
The system was successfully used to guide catheter ablation for 10 persAF patients. The mean processing time was 10.4 ± 1.5min, which is adequate comparing to the normal electrophysiological (EP) procedure time (120∼180min).


CONCLUSIONS
A customized software platform capable of measuring different forms of spatiotemporal AEG analysis was implemented and used in clinical environment to guide persAF ablation. The modular nature of the platform will help electrophysiological studies in understanding of the underlying AF mechanisms.
Behavioral and neural stability of attention bias to threat in healthy adolescents

Considerable translational research on anxiety examines attention bias to threat and the efficacy of attention training in reducing symptoms. Imaging research on the stability of brain functions engaged by attention bias tasks could inform such research. Perturbed fronto-amygdala function consistently arises in attention bias research on adolescent anxiety. The current report examines the stability of the activation and functional connectivity of these regions on the dot-probe task. Functional magnetic resonance imaging (fMRI) activation and connectivity data were acquired with the dot-probe task in 39 healthy youth (f=18, Mean Age=13.71years, SD=2.31) at two time points, separated by approximately nine weeks. Intraclass-correlations demonstrate good reliability in both neural activation for the ventrolateral PFC and task-specific connectivity for fronto-amygdala circuitry. Behavioral measures showed generally poor test-retest reliability. These findings suggest potential avenues for future brain imaging work by highlighting brain circuitry manifesting stable functioning on the dot-probe attention bias task.
Controlled, blinded force platform analysis of the effect of intraarticular injection of autologous adipose-derived mesenchymal stem cells associated to PRGF-Endoret in osteoarthritic dogs

BACKGROUND
Adipose-derived mesenchymal stem cell (ADMSC) therapy in regenerative medicine is a rapidly growing area of research and is currently also being used to treat osteoarthritis (OA). Force platform analysis has been consistently used to verify the efficacy of different therapeutic strategies for the treatment of OA in dogs, but never with AD-MSC.The aim of this study was to use a force platform to measure the efficacy of intraarticular ADMSC administration for limb function improvement in dogs with severe OA.


RESULTS
Eight lame dogs with severe hip OA and a control group of 5 sound dogs were used for this study. Results were statistically analyzed to detect a significant increase in peak vertical force (PVF) and vertical impulse (VI) in treated dogs. Mean values of PVF and VI were significantly improved after treatment of the OA groups, reaching 53.02% and 14.84% of body weight, respectively, at day 180, compared with only 43.56% and 12.16% at day 0.


CONCLUSION
This study objectively demonstrated that intraarticular ADMSC therapy resulted in reduced lameness due to OA.
Prediction of volume response under open-chest conditions during coronary artery bypass surgery

INTRODUCTION
Adequate fluid loading is the first step of hemodynamic optimization in cardiac patients undergoing surgery. Neither a clinical approach alone nor conventional parameters like central venous pressure (CVP) and pulmonary capillary wedge pressure (PCWP) are thought to be sufficient for recognizing fluid deficiency or overload. The aim of this study was to evaluate the suitability of CVP, PCWP, global end-diastolic volume index (GEDVI), pulse pressure variation (PPV), and stroke volume variation (SVV) for predicting changes in the cardiac index (CI) and stroke volume index (SVI) after sternotomy.


METHODS
In 40 patients, CVP, PCWP, GEDVI, PPV, SVV, and the CI were measured at two points of time. One measurement was performed after inducing anesthesia and one after sternotomy.


RESULTS
A significant increase in heart rate, CI, and GEDVI was observed during the study period. CVP, SVV, and PPV decreased significantly. There were no significant correlations between CVP and PCWP and changes in CI. In contrast, GEDVI, SVV, and PPV significantly correlated with CI changes. Only relative changes of GEDVI, SVV, and PPV predicted changes in SVI.


CONCLUSION
During cardiac surgery and especially after sternotomy, CVP and PCWP are not suitable for monitoring fluid status. Direct volume measurement like GEDVI and dynamic volume responsive measurements like SVV and PPV may be more suitable for monitoring the volume status of patients, particularly under open-chest conditions.
Lifecourse educational status in relation to weight gain in African American women.

OBJECTIVES
Childhood disadvantage has been associated with increased risk of obesity from childhood through adulthood and those who are disadvantaged across the lifecourse are at highest risk. The effect of lifecourse socioeconomic status (SES) is particularly important for Black women due to the higher prevalence of low SES and obesity in Black compared to White women. We assessed associations of lifecourse SES, as indicated by educational status, with adult weight in African American women.


DESIGN
We assessed the associations of parental education, current education (education of participant or her spouse), and a combination of parental and current education (lifecourse education) with weight gain among 21,457 women aged < 55 years in the longitudinal Black Women's Health Study, which began in 1995.


MAIN OUTCOME MEASURES
We estimated the mean difference in weight gain between age 18 and age in 2009, and risk ratios for obesity in 2009, in each level of education compared to the highest level (college graduate).


RESULTS
The age- and height-adjusted differences in mean weight gain for the lowest levels of parental and current education compared to the highest levels were 3.29 and 4.49 kg, respectively. The age-adjusted risk ratios for obesity for the lowest level of parental and current education were 1.44 (95% CI 1.32-1.57) and 1.75 (95% CI 1.57-1.95), respectively. Risk of obesity was lowest among those with current education of college graduate, regardless of parental education.


CONCLUSIONS
Educational level of college graduate may overcome the adverse effects of low parental education on weight gain and obesity risk.
A linear time algorithm for 7-[3]coloring triangle-free hexagonal graphs

Given a graph G, a proper n − [p]-coloring is a mapping f : V (G) → 2{1,...,n} such that |f(v)| = p for any vertex v ∈ V (G) and f(v) ∩ f(u) = ∅ for any pair of adjacent vertices u and v. n − [p]-coloring is closely related to multicoloring. Finding multicoloring of induced subgraphs of the triangular lattice (called hexagonal graphs) has important applications in cellular networks. In this article we provide an algorithm to find a 7-[3]-coloring of triangle-free hexagonal graphs in linear time, which solves the open problem stated in [10] and improves the result of Sudeep and Vishwanathan [11], who proved the existence of a 14-[6]coloring. ∗This work was supported by grant N206 017 32/2452 for years 2007-2010
High-dose corticosteroids in severe acute asthma

SIR,-In the light of recent articles concerning bromocriptine your leading article "Hormone receptors and breast cancer" (10 July, p 67) raises the possibility of the use of this drug to suppress the growth of prolactin-dependent breast tumours since, as you say, "the main peptide hormone implicated in promoting the growth of breast tumours is thought to be prolactin." The theoretical and to some extent substantiated fear of oestrogens and other hormones as carcinogenic agents should, however, perhaps now be extended to include other drugs which interfere with man's delicately balanced endocrine functions-for example, phenothiazines, methyldopa, and even indeed bromocriptine, which is used to suppress puerperal lactation, a physiological state which in itself affords some protection against breast cancer. PHILIP A KNOWLES
The paradox of NKp46+ natural killer cells: drivers of severe hepatitis C virus-induced pathology but in-vivo resistance to interferon α treatment

OBJECTIVE
There is evidence that natural killer (NK) cells help control persistent viral infections including hepatitis C virus (HCV). The phenotype and function of blood and intrahepatic NK cells, in steady state and after interferon (IFN) α treatment has not been fully elucidated.


DESIGN
We performed a comparison of NK cells derived from blood and intrahepatic compartments in multiple paired samples from patients with a variety of chronic liver diseases. Furthermore, we obtained serial paired samples from an average of five time points in HCV patients treated with IFNα.


RESULTS
Liver NK cells demonstrate a distinct activated phenotype compared to blood manifested as downregulation of the NK cell activation receptors CD16, NKG2D, and NKp30; with increased spontaneous degranulation and IFN production. In contrast, NKp46 expression was not downregulated. Indeed, NKp46-rich NK populations were the most activated, correlating closely with the severity of liver inflammation. Following initiation of IFNα treatment there was a significant increase in the proportion of intrahepatic NK cells at days 1 and 3. NKp46-rich NK populations demonstrated no reserve activation capacity with IFNα treatment and were associated with poor viral control on treatment and treatment failure.


CONCLUSIONS
NKp46 marks out pathologically activated NK cells, which may result from a loss of homeostatic control of activating receptor expression in HCV. Paradoxically these pathological NK cells do not appear to be involved in viral control in IFNα-treated individuals and, indeed, predict slower rates of viral clearance.
Automatic Airspace Sectorisation: A Survey

Airspace sectorisation provides a partition of a given airspace into sectors, subject to geometric constraints and workload constraints, so that some cost metric is minimised. We survey the algorithmic aspects of methods for automatic airspace sectorisation, for an intended readership of experts on air traffic management.
Dual-Band Terahertz Metamaterial Absorber with Polarization Insensitivity and Wide Incident Angle

This paper presents the design, simulation and measurement of a dual-band terahertz metamaterial absorber with polarization-insensitivity and wide incident angle. The unit cell of the metamaterial consists of top resonator structures and low metallic ground plane, separated by an isolation material spacer to realize both electric and magnetic resonances. The physical mechanism of dual-band absorption and the sensitivity to the polarization direction and incident direction of the EM wave are theoretically investigated by simulating the x-component and normal component electric field distribution, current distribution on ERRs and metallic ground plane, and distribution of power flow and loss at the resonance frequencies as well as different modes EM waves, based the FDTD calculated method, respectively. The results show that the absorber is not only correctly coupling to the incident electric field and magnetic field, but also can trap the input power into specific positions of the devices and absorb it, besides insensitivity to the polarized angle and incident angle. Moreover, the experiment demonstrates that the absorber achieves two strong absorptions of 82.8% and 86.8% near 1.724 and 3.557 THz. Received 23 February 2011, Accepted 2 April 2011, Scheduled 8 April 2011 Corresponding author: Xun-Jun He (hexunjun@yahoo.com.cn).
Subgingival microbiota dysbiosis in systemic lupus erythematosus: association with periodontal status

BACKGROUND
Periodontitis results from the interaction between a subgingival biofilm and host immune response. Changes in biofilm composition are thought to disrupt homeostasis between the host and subgingival bacteria resulting in periodontal damage. Chronic systemic inflammatory disorders have been shown to affect the subgingival microbiota and clinical periodontal status. However, this relationship has not been examined in subjects with systemic lupus erythematosus (SLE). The objective of our study was to investigate the influence of SLE on the subgingival microbiota and its connection with periodontal disease and SLE activity.


METHODS
We evaluated 52 patients with SLE compared to 52 subjects without SLE (control group). Subjects were classified as without periodontitis and with periodontitis. Oral microbiota composition was assessed by amplifying the V4 region of 16S rRNA gene from subgingival dental plaque DNA extracts. These amplicons were examined by Illumina MiSeq sequencing.


RESULTS
SLE patients exhibited higher prevalence of periodontitis which occurred at a younger age compared to subjects of the control group. More severe forms of periodontitis were found in SLE subjects that had higher bacterial loads and decreased microbial diversity. Bacterial species frequently detected in periodontal disease were observed in higher proportions in SLE patients, even in periodontal healthy sites such as Fretibacterium, Prevotella nigrescens, and Selenomonas. Changes in the oral microbiota were linked to increased local inflammation, as demonstrated by higher concentrations of IL-6, IL-17, and IL-33 in SLE patients with periodontitis.


CONCLUSIONS
SLE is associated with differences in the composition of the microbiota, independently of periodontal status.
Social Security Reform with Heterogeneous Agents

This paper analyzes the quantitative role of idiosyncratic uncertainty in an economy in which rational agents vote on hypothetical social security reforms. We find that the role of a pay-as-you-go social security system as a partial insurance and redistribution device significantly reduces political support for a transition to an economy with a fully funded system. We conclude that the status quo bias in favor of an unfunded social security system is stronger in economies in which agents of similar age differ significantly with respect to labor earnings and wealth because of idiosyncratic income uncertainty. Journal of Economic Literature Classification Numbers: H55, E62, H3 Q 1999 Academic Press
Safety of percutaneous coronary intervention during uninterrupted oral anticoagulant treatment.

AIMS
Uninterrupted anticoagulation (UAC) is assumed to increase bleeding and access-site complications. A common consensus is to postpone percutaneous coronary interventions (PCI) to reach international normalized ratio (INR) levels < 1.5-1.8.


METHODS AND RESULTS
To assess the safety and feasibility of UAC, we analysed retrospectively all consecutive patients (n = 523) on warfarin therapy referred for PCI in four centres with a policy to interrupt anticoagulation (IAC) before PCI and in three centres with a long experience on UAC during PCI. Major bleeding, access-site complications, and major adverse cardiac events (death, myocardial infarction, target vessel revascularization, and stent thrombosis) were recorded during hospitalization. In the IAC group, warfarin was withdrawn for a mean of 3 days prior to PCI (mean INR 1.7). In the UAC group, mean INR value was 2.2. Glycoprotein IIb/IIIa (GP) inhibitors (P < 0.001) and low-molecular-weight heparins (P < 0.001) were more often used in the IAC group. Major bleeding and access-site complications were more common in the IAC group (5.0% vs. 1.2%, P = 0.02 and 11.3% vs. 5.0%, P = 0.01, respectively) than in the UAC group. After adjusting for propensity score, the group difference in access-site complications remained significant [OR (odds ratio) 2.8, 95% CI (confidence interval) 1.3-6.1, P = 0.008], but did not remain significant in major bleeding (OR 3.9, 95% CI 1.0-15.3, P = 0.05). In multivariable analysis, femoral access (OR 9.9, 95% CI 1.3-75.2), use of access-site closure devices (OR 2.1, 95% CI 1.1-4.0), low-molecular-weight heparin (OR 2.7, 95% CI 1.1-6.7) and old age predicted access-site complications, and the use of GP inhibitors (OR 3.0, 95% CI 1.0-9.1) remained as a predictor of major bleeding.


CONCLUSION
Our study shows that PCI is a safe procedure during UAC with no excess bleeding complications.
Process Evaluation of a Psychosocial Intervention Addressing Women in a Disadvantaged Setting

OBJECTIVES
This paper presents the process evaluation of a community-based randomized psycho-social trial aimed to enhance reproductive and mental health outcomes of disadvantaged women living in the southern suburb of Beirut-Lebanon. Process evaluation of public health interventions involves the monitoring and documentation of interventions' implementation to allow for better understanding of planned outcomes and of intervention effectiveness.


METHODS
A community-based randomized trial was conducted. The intervention consisted of 12 sessions (of combined 30 minutes of relaxation exercises and 75 minutes of structured support groups) delivered twice per week over a period of six-weeks. A process evaluation was conducted during the implementation of the intervention. This process evaluation aimed to ensure that the intervention was delivered and implemented as planned, as well as to monitor women's satisfaction and attendance. The main components of the process evaluation included: dose delivered, dose received, and reach. Closed ended questionnaires were administered before/after/during each intervention session. Data was entered and analyzed using SPSS. Analysis revolved around simple frequency distribution for categorical variables and means (SD) for continuous variables. Limited bivariate analysis (using CHI Square and Anova) was done.


RESULTS
RESULTS indicated that the delivery, implementation, and reach of the intervention were favorable. Participation was acceptable and satisfaction rates were very high.


CONCLUSION
These favorable findings pertaining to intervention satisfaction, reach and participation highlight a number of lessons for future intervention studies in the context of disadvantaged settings. They also support the importance of involving the local community members in intervention planning, implementation and evaluation early on. We believe that the community involvement in this trial directly and significantly contributed to the results of this process evaluation.