LLukas22/scidocs huggingface dataset:
Neoadjuvant FOLFOX 4 versus FOLFOX 4 with Cetuximab versus immediate surgery for high-risk stage II and III colon cancers: a multicentre randomised controlled phase II trial – the PRODIGE 22 - ECKINOXE trial

In patients with high risk stage II and stage III colon cancer (CC), curative surgery followed by adjuvant FOLFOX-4 chemotherapy has become the standard of care. However, for 20 to 30 % of these patients, the current curative treatment strategy of surgical excision followed by adjuvant chemotherapy fails either to clear locoregional spread or to eradicate distant micrometastases, leading to disease recurrence. Preoperative chemotherapy is an attractive concept for these CCs and has the potential to impact upon both of these causes of failure. Optimum systemic therapy at the earliest possible opportunity may be more effective at eradicating distant metastases than the same treatment given after the delay and immunological stress of surgery. Added to this, shrinking the primary tumor before surgery may reduce the risk of incomplete surgical excision, and the risk of tumor cell shedding during surgery. PRODIGE 22 - ECKINOXE is a multicenter randomized phase II trial designed to evaluate efficacy and feasibility of two chemotherapy regimens (FOLFOX-4 alone and FOLFOX-4 + Cetuximab) in a peri-operative strategy in patients with bulky CCs. Patients with CC deemed as high risk T3, T4 and/or N2 on initial abdominopelvic CT scan are randomized to either colectomy and adjuvant chemotherapy (control arm), or 4 cycles of neoadjuvant chemotherapy with FOLFOX-4 (for RAS mutated patients). In RAS wild-type patients a third arm testing FOLFOX+ cetuximab has been added prior to colectomy. Patients in the neoadjuvant chemotherapy arms will receive postoperative treatment for 4 months (8 cycles) to complete their therapeutic schedule. The primary endpoint of the study is the histological Tumor Regression Grade (TRG) as defined by Ryan. The secondary endpoints are: treatment strategy safety (toxicity, primary tumor related complications under chemotherapy, peri-operative morbidity), disease-free and recurrence free survivals at 3 years, quality of life, carcinologic quality and completeness of the surgery, initial radiological staging and radiological response to neoadjuvant chemotherapy, and the correlation between histopathological and radiological response. Taking into account a 50 % prevalence of CC without RAS mutation, accrual of 165 patients is needed for this Phase II trial. NCT01675999 (ClinicalTrials.gov)
Enterprise resource planning systems: comparing firm performance of adopters and nonadopters

The current study examined the longitudinal impact of ERP adoption on firm performance by matching 63 firms identified by Hayes et al. [J. Inf. Syst. 15 (2001) 3] with peer firms that had not adopted ERP systems. Results indicate that return on assets (ROA), return on investment (ROI), and asset turnover (ATO) were significantly better over a 3-year period for adopters, as compared to nonadopters. Interestingly, our results are consistent with Poston and Grabski [Int. J. Account. Inf. Syst. 2 (2001) 271] who reported no preto post-adoption improvement in financial performance for ERP firms. Rather, significant differences arise in the current study because the financial performance of nonadopters decreased over time while it held steady for adopters. We also report a significant interaction between firm size and financial health for ERP adopters with respect to ROA, ROI, and return on sales (ROS). Specifically, we found a positive (negative) relationship between financial health and performance for small (large) firms. Study findings shed new light on the productivity paradox associated with ERP systems and suggest that ERP adoption helps firms gain a competitive advantage over nonadopters. D 2003 Elsevier Science Inc. All rights reserved.
Multiple-center evaluation of mortality associated with acute kidney injury in critically ill patients: a competing risks analysis

INTRODUCTION
In this study, we aimed to assess the association between acute kidney injury (AKI) and mortality in critically ill patients using an original competing risks approach.


METHODS
Unselected patients admitted between 1997 and 2009 to 13 French medical or surgical intensive care units were included in this observational cohort study. AKI was defined according to the RIFLE criteria. The following data were recorded: baseline characteristics, daily serum creatinine level, daily Sequential Organ Failure Assessment (SOFA) score, vital status at hospital discharge and length of hospital stay. Patients were classified according to the maximum RIFLE class reached during their ICU stay. The association of AKI with hospital mortality with "discharge alive" considered as a competing event was assessed according to the Fine and Gray model.


RESULTS
Of the 8,639 study patients, 32.9% had AKI, of whom 19.1% received renal replacement therapy. Patients with AKI had higher crude mortality rates and longer lengths of hospital stay than patients without AKI. In the Fine and Gray model, independent risk factors for hospital mortality were the RIFLE classes Risk (sub-hazard ratio (SHR) 1.58 and 95% confidence interval (95% CI) 1.32 to 1.88; P < 0.0001), Injury (SHR 3.99 and 95% CI 3.43 to 4.65; P < 0.0001) and Failure (SHR 4.12 and 95% CI 3.55 to 4.79; P < 0.0001); nonrenal SOFA score (SHR 1.19 per point and 95% CI 1.18 to 1.21; P < 0.0001); McCabe class 3 (SHR 2.71 and 95% CI 2.34 to 3.15; P < 0.0001); and respiratory failure (SHR 3.08 and 95% CI 1.36 to 7.01; P < 0.01).


CONCLUSIONS
By using a competing risks approach, we confirm in this study that AKI affecting critically ill patients is associated with increased in-hospital mortality.
Cognition as a dynamic system : Principles from embodiment

Traditional approaches to cognitive development concentrate on the stability of cognition and explain that stability via concepts segregated from perceiving acting. A dynamic systems approach in contrast focuses on the self-organization of behavior in tasks. This article uses recent results concerning the embodiment of cognition to argue for a dynamic systems approach. The embodiment hypothesis is the idea that intelligence emerges in the interaction of an organism with an environment and as a result of sensory-motor activity. The continual coupling of cognition to the world through the body both adapts cognition to the idiosyncrasies of the here and now, makes it relevant, and provides the mechanism for developmental change. 2005 Elsevier Inc. All rights reserved.
A Crowdsourced Alternative to Eye-tracking for Visualization Understanding

In this study we investigate the utility of using mouse clicks as an alternative for eye fixations in the context of understanding data visualizations. We developed a crowdsourced study online in which participants were presented with a series of images containing graphs and diagrams and asked to describe them. Each image was blurred so that the participant needed to click to reveal bubbles - small, circular areas of the image at normal resolution. This is similar to having a confined area of focus like the human eye fovea. We compared the bubble click data with the fixation data from a complementary eye-tracking experiment by calculating the similarity between the resulting heatmaps. A high similarity score suggests that our methodology may be a viable crowdsourced alternative to eye-tracking experiments, especially when little to no eye-tracking data is available. This methodology can also be used to complement eye-tracking studies with an additional behavioral measurement, since it is specifically designed to measure which information people consciously choose to examine for understanding visualizations. \
New strategies to detect alcohol use disorders in the preoperative assessment clinic of a German university hospital.

BACKGROUND
Although alcohol use disorders (AUDs) have enormous public health consequences, the rate of diagnosis of AUDs remains unsatisfactorily low. The primary aim of this study was to compare the detection of AUDs by anesthesiologists in a large preoperative assessment clinic to that by computerized self-assessment of the Alcohol Use Disorder Identification Test. Secondary outcome measures were to compare the actions taken by anesthesiologists upon a finding of an AUD.


METHODS
One thousand five hundred fifty-six patients were included. Before preoperative assessment, patients were asked to complete the Alcohol Use Disorder Identification Test (positive scores: men > or = 8, women > or = 5) using a computer. The authors performed a retrospective chart analysis of the anesthesiologists' actions upon a finding of an AUD. The anesthesiologists were blinded to the results of the computer-based assessment and to the subsequent chart analysis.


RESULTS
The prevalence rate of AUDs determined by the anesthesiologists was 6.9% (107 of 1,556), whereas the proportion of patients positive for an AUD using the computerised Alcohol Use Disorder Identification Test was 18.1% (282 of 1,556) (P < 0.001). The detection rate by the anesthesiologists of AUDs among men was significantly higher than among women (P < 0.001) as well as in the elderly compared with younger patients (P < 0.001). Action taken by anesthesiologists was mainly based on evaluating quantity of alcohol consumption.


CONCLUSION
The computer-based self-assessment increases detection rates of AUDs in busy settings such as a preoperative assessment clinic. Prevalence rates of AUDs are underestimated. Best-practice guidelines for detection of AUDs are not implemented in the daily clinical routine. Barrier analysis is urgently required.
On a Reconstruction Problem of Harary and Manvel

We give a complete answer to a question raised by Harary and Manvel in 1972 (Bull. Soc. Math. Belg.24, 375?379) by proving that a finite set A of points in the plane R2 is uniquely determined up to translation and rotation by a multiple of 90° by 5 of its (?A??1)-element subsets given up to translation and rotation by a multiple of 90°. This result is best possible.
Distinct developmental trends in sleep duration during early childhood.

BACKGROUND AND OBJECTIVES
Sleep is important to child development, but there is limited understanding of individual developmental patterns of sleep, their underlying determinants, and how these influence health and well-being. This article explores the presence of various sleep patterns in children and their implications for health-related quality of life.


METHODS
Data were collected from the Longitudinal Study of Australian Children. Participants included 2926 young children followed from age 0 to 1 years to age 6 to 7 years. Data on sleep duration were collected every 2 years, and covariates (eg, child sleep problems, maternal education) were assessed at baseline. Growth mixture modeling was used to identify distinct longitudinal patterns of sleep duration and significant covariates. Linear regression examined whether the distinct sleep patterns were significantly associated with health-related quality of life.


RESULTS
The results identified 4 distinct sleep duration patterns: typical sleepers (40.6%), initially short sleepers (45.2%), poor sleepers (2.5%), and persistent short sleepers (11.6%). Factors such as child sleep problems, child irritability, maternal employment, household financial hardship, and household size distinguished between the trajectories. The results demonstrated that the trajectories had different implications for health-related quality of life. For instance, persistent short sleepers had poorer physical, emotional, and social health than typical sleepers.


CONCLUSIONS
The results provide a novel insight into the nature of child sleep and the implications of differing sleep patterns for health-related quality of life. The findings could inform the development of effective interventions to promote healthful sleep patterns in children.
Unified Description of Inclusive and Exclusive Reactions at All Momentum Transfers

R. Blankenbecler and S. J. Brodsky Stanford Linear Accelerator Center Stanford University, Stanford, Calif. 94305 ABSTRACT The constituent interchange model is used to relate large and small momentum transfer reactions, to relate inclusive and exclusive processes, and to predict the form of the inclusive cross section throughout the Peyrou plot. Two important corrections to the triple Regge formula are derived. The first, important at small missing mass, allows a smooth connection to exclusive processes. The second, important at large missing mass, allows a smooth connection to the central region and to the large transverse momentum regime. Simple quark counting rules are given which predict the limiting behavior of Regge trajectories and residue functions, and the powers of Pi and the missing mass dependence of inclusive cross sections. Many experimental consequences of the model are given.
The Exploitation of Models in Artificial Emotions

Cognitive processes might be seen as reciprocal items and they are usually characterized by multiple feedback cycles. Emotions constitute one major source of feedback loops to assure the maintenance of well-being, providing cognitive processes with quantifiable meaning. This suggests the exploitation of models to improve the adaptation under value-based protocols. Emotion is not an isolated effect of stimuli, but it is the set of several effects of the stimuli and the relationships among them. This chapter proposes a study of the exploitation of models in artificial emotions, pointing out relationships as part of the model as well as the model exploitation method.
Learning Dynamic Embeddings from Temporal Interactions

Modeling a sequence of interactions between users and items (e.g., products, posts, or courses) is crucial in domains such as e-commerce, social networking, and education to predict future interactions. Representation learning presents an attractive solution to model the dynamic evolution of user and item properties, where each user/item can be embedded in a euclidean space and its evolution can be modeled by dynamic changes in its embedding. However, existing embedding methods either generate static embeddings, treat users and items independently, or are not scalable. Here we propose JODIE, a coupled recurrent model to jointly learn the dynamic embeddings of users and items from a sequence of user-item interactions. JODIE has three components. First, the update component updates the user and item embedding from each interaction using their previous embeddings with the two mutuallyrecursive Recurrent Neural Networks. Second, a novel projection component is trained to forecast the embedding of users at any future time. Finally, the prediction component directly predicts the embedding of the item in a future interaction. For models that learn from a sequence of interactions, traditional batching of training data can not be done due to complex user-user dependencies. Therefore, we present a novel batching algorithm called t-Batch that generates time-consistent batches that can be run in parallel, leading to massive speed-up. We conduct six experiments to validate JODIE on two prediction tasks—future interaction prediction and state change prediction— using four real-world datasets. We show that JODIE outperforms six state-of-the-art algorithms in these tasks by up to 22.4%. Moreover, we show that JODIE is highly scalable and up to 9.2× faster than comparable models. As an additional experiment, we illustrate that JODIE can predict student drop-out from courses up to five interactions in advance. ACM Reference Format: Srijan Kumar, Xikun Zhang, and Jure Leskovec. 2018. Learning Dynamic Embeddings from Temporal Interaction Networks. In Proceedings of ACM Conference (Conference’17). ACM, New York, NY, USA, 11 pages. https: //doi.org/10.1145/nnnnnnn.nnnnnnn
A coronary heart disease prediction model: the Korean Heart Study

OBJECTIVE
The objectives of this study were to develop a coronary heart disease (CHD) risk model among the Korean Heart Study (KHS) population and compare it with the Framingham CHD risk score.


DESIGN
A prospective cohort study within a national insurance system.


SETTING
18 health promotion centres nationwide between 1996 and 2001 in Korea.


PARTICIPANTS
268 315 Koreans between the ages of 30 and 74 years without CHD at baseline.


OUTCOME MEASURE
Non-fatal or fatal CHD events between 1997 and 2011. During an 11.6-year median follow-up, 2596 CHD events (1903 non-fatal and 693 fatal) occurred in the cohort. The optimal CHD model was created by adding high-density lipoprotein (HDL)-cholesterol, low-density lipoprotein (LDL)-cholesterol and triglycerides to the basic CHD model, evaluating using the area under the receiver operating characteristic curve (ROC) and continuous net reclassification index (NRI).


RESULTS
The optimal CHD models for men and women included HDL-cholesterol (NRI=0.284) and triglycerides (NRI=0.207) from the basic CHD model, respectively. The discrimination using the CHD model in the Korean cohort was high: the areas under ROC were 0.764 (95% CI 0.752 to 0.774) for men and 0.815 (95% CI 0.795 to 0.835) for women. The Framingham risk function predicted 3-6 times as many CHD events than observed. Recalibration of the Framingham function using the mean values of risk factors and mean CHD incidence rates of the KHS cohort substantially improved the performance of the Framingham functions in the KHS cohort.


CONCLUSIONS
The present study provides the first evidence that the Framingham risk function overestimates the risk of CHD in the Korean population where CHD incidence is low. The Korean CHD risk model is well-calculated alternations which can be used to predict an individual's risk of CHD and provides a useful guide to identify the groups at high risk for CHD among Koreans.
Childhood trauma and adult interpersonal relationship problems in patients with depression and anxiety disorders

INTRODUCTION
Although a plethora of studies have delineated the relationship between childhood trauma and onset, symptom severity, and course of depression and anxiety disorders, there has been little evidence that childhood trauma may lead to interpersonal problems among adult patients with depression and anxiety disorders. Given the lack of prior research in this area, we aimed to investigate characteristics of interpersonal problems in adult patients who had suffered various types of abuse and neglect in childhood.


METHODS
A total of 325 outpatients diagnosed with depression and anxiety disorders completed questionnaires on socio-demographic variables, different forms of childhood trauma, and current interpersonal problems. The Childhood Trauma Questionnaire (CTQ) was used to measure five different forms of childhood trauma (emotional abuse, emotional neglect, physical abuse, physical neglect, and sexual abuse) and the short form of the Korean-Inventory of Interpersonal Problems Circumplex Scale (KIIP-SC) was used to assess current interpersonal problems. We dichotomized patients into two groups (abused and non-abused groups) based on CTQ score and investigated the relationship of five different types of childhood trauma and interpersonal problems in adult patients with depression and anxiety disorders using multiple regression analysis.


RESULT
Different types of childhood abuse and neglect appeared to have a significant influence on distinct symptom dimensions such as depression, state-trait anxiety, and anxiety sensitivity. In the final regression model, emotional abuse, emotional neglect, and sexual abuse during childhood were significantly associated with general interpersonal distress and several specific areas of interpersonal problems in adulthood. No association was found between childhood physical neglect and current general interpersonal distress.


CONCLUSION
Childhood emotional trauma has more influence on interpersonal problems in adult patients with depression and anxiety disorders than childhood physical trauma. A history of childhood physical abuse is related to dominant interpersonal patterns rather than submissive interpersonal patterns in adulthood. These findings provide preliminary evidence that childhood trauma might substantially contribute to interpersonal problems in adulthood.
The Factors Affecting the Clinical Outcome and Integrity of Arthroscopically Repaired Rotator Cuff Tears of the Shoulder

BACKGROUND
The purpose of this study was to evaluate the functional and anatomic results of arthroscopic rotator cuff repair, and to analyze the factors affecting the integrity of arthroscopically repaired rotator cuff tears of the shoulder.


METHODS
One hundred sixty-nine consecutive shoulders that underwent arthroscopic rotator cuff repair, had a postoperative MRI evaluation and were followed for at least two years were enrolled in this study. The mean age was 57.6 years (range, 38 to 74 years) and the mean follow-up period was 39 months (range, 24 to 83 months).


RESULTS
The rotator cuff was completely healed in 131 (77.5%) out of 169 shoulders and recurrent tears occurred in 38 shoulders (22.5%). At the last follow-up visit, the mean score for pain during motion was 1.53 (range, 0 to 4) in the completely healed group and 1.59 (range, 0 to 4) in the group with recurrent tears (p = 0.092). The average elevation strength was 7.87 kg (range, 4.96 to 11.62 kg) and 5.25 kg (range, 4.15 to 8.13 kg) and the mean University of California at Los Angeles score was 30.96 (range, 26 to 35) and 30.64 (range, 23 to 34), respectively (p < 0.001, p = 0.798). The complete healing rate was 87.8% in the group less than 50 years of age (49 shoulders), 79.4% in the group over 51 years but less than 60 years of age (68 shoulders), and 65.4% in the group over 61 years of age (52 shoulders, p = 0.049); it was 96.7% in the group with small-sized tears (30 shoulders), 87.3% in the group with medium-sized tears (71 shoulders), and 58.8% in the group with large-sized or massive tears (68 shoulders, p = 0.009). All of the rotator cuffs with a global fatty degeneration index of greater than two preoperatively had recurrent tears.


CONCLUSIONS
Arthroscopic repair of full-thickness rotator cuff tears led to a relatively high rate of recurrent defects. However, the minimum two-year follow up demonstrated excellent pain relief and improvement in the ability to perform the activities of daily living, despite the structural failures. The factors affecting tendon healing were the patient's age, the size and extent of the tear, and the presence of fatty degeneration in the rotator cuff muscle.