LLukas22/scidocs huggingface dataset:
Susceptibility Of Ph-Positive All To Tki Therapy Associated With Bcr-Abl Rearrangement Patterns: A Retrospective Analysis

BACKGROUND
Tyrosine kinase inhibitors (TKIs) have demonstrated success in the treatment of acute lymphoblastic leukemia (ALL) in patients that express BCR-ABL rearrangements (Philadelphia chromosome [Ph]). The current study aimed to assess the efficacy of TKIs and prognostic factors in the treatment of adults with Ph+-ALL.


METHODS
In this multicenter retrospective study, the relationship between Ph+-ALL and treatment outcomes among Chinese patients receiving TKI-containing induction/consolidation chemotherapy was examined. A total of 86 Ph+-ALL patients were included and followed for 3.85 (0.43-9.30) years. Overall survival (OS) and event-free survival (EFS) were analyzed.


RESULTS
A total of 86 Ph+-ALL patients (40 females and 46 males; median age: 34.0 years) were enrolled, including those with BCR/ABL transcripts 190 (n = 52), 210 (n = 25), and 230 (n = 2); BCR/ABL isoform determination was not available for 7 patients. Mortality was influenced by variable BCR/ABL transcripts and TKI administration, and BCR/ABL transcripts, hematopoietic stem cell transplantation (HSCT), and TKI administration were associated with the occurrence of events. The OS rate in the TKI administration group during steady state was significantly higher compared with those patients who did not receive TKI administration (P = 0.008), the EFS rate in the TKI administration group during steady state was significantly higher compared with those patients who did not receive TKIs (P = 0.012), and also higher than those with TKI salvage administration (P = 0.004). BCR/ABL transcripts 210 showed preferable OS and EFS compared with BCR/ABL transcripts 190 and 230 (P<0.05 for each).


CONCLUSIONS
The susceptibility of Ph+-ALL to TKI associated with the patterns of BCR-ABL rearrangement is demonstrated for the first time, thus adding another risk-stratifying molecular prognostic tool for the management of patients with Ph+-ALL.
The Impact of Project Management in Virtual Environment: A Software Industry Perspective

Virtual team in a project within an organization could achieve optimize project performance by acquiring appropriate human resources, coordination, communication and regular performance evaluation. According to the literature many ICT tools will collaborate to manage virtual teams, but still most of the projects lead to failure in the software industry. Aim of this research is to discover the most affected factors for virtual project human resource management.
Gender issues in preservice teachers' training: ICT literacy and online learning

Gender differences in self reported ICT experience and ICT literacy among first year graduate trainee teachers were investigated. Using a dynamic model, three main components of aspiring teachers’ ICT literacy were covered: (1) present general problem solving and technical ICT capabilities; (2) situational and longitudinal sustainability, and (3) transferability of ICT capabilities into a future professional domain. No significant differences were found between females and males for previous experience with ICT. However, males on average worked with computers significantly more hours per week than females. Significant differences between males and females were observed for technical ICT capabilities, and situational and longitudinal sustainability. Males’ scores were higher. In the regression analysis, when the impacts of the background and ICT experience variables were controlled, gender failed to be a significant predictor for sustainability scores. However, it remained a significant predictor for some trainee teachers’ scores, related to their technical ICT capabilities. Female and male participation in compulsory online learning activities was also compared. No significant differences were observed.
Design of a Four-Band and Polarization-Insensitive Terahertz Metamaterial Absorber

We present a four-band and polarization-insensitive terahertz metamaterial absorber formed by four square metallic rings and a metallic ground plane separated by a dielectric layer. It is found that the structure has four distinctive absorption bands whose peaks are over 97% on average. The mechanism of the four-band absorber is attributed to the overlapping of four resonance frequencies, and the mechanism of the absorption is investigated by the distributions of the electric field. In particular, the frequency of each absorption peak can be flexibly controlled by varying the size of the corresponding metallic ring. The proposed concept is applicable to other types of absorber structures and can be readily scaled up to the structures that are working in the microwave frequency range. Moreover, the characteristic of the design can be used to design a five-band metamaterial absorber by adding one more metallic ring. The proposed absorber has potential applications in detection, imaging, and stealth technology.
Secure Mobile Payments Based on Cloud Services: Concepts and Experiments

This paper presents an innovative and open concept for secure mobile payments, based on payment applications hosted in the cloud. It details an experimental Android platform, and NFC payment experiments performed with this platform. All the platform components rely on open technologies, i.e. available in commercial devices or specified by IETF drafts. On the mobile side security is enforced by a dedicated protocol (based on TLS), running in a secure element. This protocol manages the access to remote payment applications, running in secure elements, hosted in dedicated servers. This approach creates a new entity that collects meaningful and relevant data, dealing with user's purchases. It also increases the level of trust both for consumers and banks.
Associations of maternal pre-pregnancy underweight with small-for-gestational-age and spontaneous preterm birth, and optimal gestational weight gain in Japanese women.

AIM
To determine associations of maternal pre-pregnancy underweight with poor outcomes and evaluate how gestational weight gain affects risks for such outcomes in pre-pregnancy underweight Japanese women.


METHODS
By analyzing the January 2001-December 2012 hospital database, we retrospectively identified 6954 women with pre-pregnancy normal weights (body mass index, 18.5-24.9 kg/m²) and 1057 pre-pregnancy underweight women (body mass index, <18.5 kg/m²) who delivered at the Perinatal Maternity and Neonatal Center of Yokohama City University. These women were stratified by weekly weight gain during the second/third trimesters to investigate associations of gestational weight gain with spontaneous preterm birth and small for gestational age (SGA). Spontaneous preterm birth and SGA incidences were compared with those of women meeting Institute of Medicine (IO M) guidelines to determine optimal weight gain in Japanese women.


RESULTS
Preterm birth and SGA incidences were significantly higher in pre-pregnancy underweight than in pre-pregnancy normal weight women (4.6% vs 2.4% [P=0.005] and 13.9% vs 9.7% [P = 0.003], respectively). For pre-pregnancy normal weight women, preterm birth incidence was significantly higher in those with weight gain of less than 0.2 kg/week than in those IOM guidelines. For pre-pregnancy underweight women, preterm birth and SGA incidences were significantly higher in those with weight gain of less than 0.3 kg/week than in those meeting IOM guidelines.


CONCLUSION
Preterm birth and SGA incidences did not differ significantly between pre-pregnancy normal weight women with weight gain of 0.2 kg/week or more and pre-pregnancy underweight women with weight gain of 0.3 kg/week or more, as compared to women meeting IOM guidelines. These results suggest that IOM guidelines for gestational weight gain may lack external validity in Japanese women.
Comparative methods offer powerful insights into social evolution in bees

Bees are excellent models for studying the evolution of sociality. While most species are solitary, many form social groups. The most complex form of social behavior, eusociality, has arisen independently four times within the bees. Subsequent elaborations of the reproductive division of labor inherent to eusociality have led to the evolution of some of the most highly advanced forms of eusociality documented. Likewise, many reversals back to solitary behavior also create substantial variation in sociality within the bees. These replicated, independent origins and losses enable a comparative approach that facilitates the search for common mechanisms underlying transitions from solitary to group living. In this review, we discuss the extensive behavioral variation found within the bees and highlight how the comparative method has improved our understanding of social evolution. Finally, we discuss potential difficulties with this approach and outline promising avenues for future research.
THREE : SORTING OUT THE APPLES , PEARS AND FRUIT SALADS IN INCUBATOR PERFORMANCE EVALUATION

Incubators are becoming a ubiquitous phenomenon in many parts of the world since they are regarded as solutions to increase the birth rates of technology-based enterprises. Considering the large amounts of money invested in incubators, the identification of best practices is of importance. This requires performance comparisons between incubators using different incubator models. The aim of the paper is twofold: (1) to sort out the key concepts and identify some of the problems inherent in the evaluation and comparison of incubator performance and leading to “apple-and-pear” comparisons and (2) to develop a framework that can serve as a basis for identifying best practice incubator models. We argue that it is necessary to take goal differences between incubators into account if performance instead of outcome is to be measured. Further, we identify the need to distinguish different incubator model from each other. We put forward a framework in which differences with regard to three key incubator model components are emphasised: selection strategies, business support strategies and mediation. Future research includes the empirical testing of this framework. If it proves to be generally useful, it will be applied in best practice studies. INTRODUCTION The concept of ‘incubator’ is often used as an overall denomination for organisations that constitute or create a supportive environment that is conducive to the “hatching” and development of new firms (Chan and Lau, 2005; LindholmDahlstrand and Klofsten, 2002; Lyons and Li, 2003; VINNOVA, 2004). Such incubators are becoming a ubiquitous phenomenon in many parts of the world. Policy makers on national and local levels have come to view them as a tool for promoting the emergence of new technology-based growth firms, economic development and innovativeness. They are used as vitamin injections for ‘tired’ regions and as contraction-stimulators or painkillers in the birth of university spin-offs. Considering the great credence for – and the large amounts of money invested in – incubators by governments, universities, research institutions, municipal agencies and other interested parties, the question of what return society gets on these investments has been raised. An important research issue has, therefore, been to describe the ‘value-added’ of incubators in comparison to other business environments, i.e. their unique contribution to new venture development, survival and growth and entrepreneurship (Chan and Lau, 2005; Phan et al., 2005):
Clinical and financial implications of emergency department visits for synthetic marijuana.

BACKGROUND
Many users believe that synthetic cannabinoids offer a safe and legal means of getting high. However, spikes in emergency department visits have been associated with use of synthetic cannabinoids. The purpose of the current study was to document emergency department visits from three large hospitals in one metropolitan area over a two month period.


METHOD
This was a retrospective chart review examining 218 patients presenting to three inner city emergency departments between March and April 2014. Data collected included demographic information, information regarding ED diagnosis and treatment, signs and symptoms, ancillary testing, ED disposition, and cost of the medical treatment.


RESULTS
The majority of patients (75.7%) were discharged after ED workup, but 12.4% were admitted for medical treatment and 11.5% were admitted for psychiatric treatment. Ten patients (4.6%) were admitted to the ICU. Symptoms experienced most frequently include: hypertension, tachycardia, agitation, drowsiness, nausea, and confusion. Cluster analysis revealed four symptom clusters of individuals presenting after using synthetic cannabinoids: 1) confusion, hostility, agitation, 2) nausea, vomiting, abdominal pain, 3) drowsiness, and 4) the absence of these symptoms.


CONCLUSION
This study has three important findings. First, significant ED resources are being used to treat individuals presenting due to effects of synthetic cannabis. Second, synthetic cannabis is not a benign substance. Third, while the hostile and agitated user is generally presented in the media, this study finds significant heterogeneity in presentation. Further research is needed to fully understand the implications of synthetic cannabinoid use.
Treatment of atrial fibrillation by the ablation of localized sources: CONFIRM (Conventional Ablation for Atrial Fibrillation With or Without Focal Impulse and Rotor Modulation) trial.

OBJECTIVES
We hypothesized that human atrial fibrillation (AF) may be sustained by localized sources (electrical rotors and focal impulses), whose elimination (focal impulse and rotor modulation [FIRM]) may improve outcome from AF ablation.


BACKGROUND
Catheter ablation for AF is a promising therapy, whose success is limited in part by uncertainty in the mechanisms that sustain AF. We developed a computational approach to map whether AF is sustained by several meandering waves (the prevailing hypothesis) or localized sources, then prospectively tested whether targeting patient-specific mechanisms revealed by mapping would improve AF ablation outcome.


METHODS
We recruited 92 subjects during 107 consecutive ablation procedures for paroxysmal or persistent (72%) AF. Cases were prospectively treated, in a 2-arm 1:2 design, by ablation at sources (FIRM-guided) followed by conventional ablation (n = 36), or conventional ablation alone (n = 71; FIRM-blinded).


RESULTS
Localized rotors or focal impulses were detected in 98 (97%) of 101 cases with sustained AF, each exhibiting 2.1 ± 1.0 sources. The acute endpoint (AF termination or consistent slowing) was achieved in 86% of FIRM-guided cases versus 20% of FIRM-blinded cases (p < 0.001). FIRM ablation alone at the primary source terminated AF in a median 2.5 min (interquartile range: 1.0 to 3.1 min). Total ablation time did not differ between groups (57.8 ± 22.8 min vs. 52.1 ± 17.8 min, p = 0.16). During a median 273 days (interquartile range: 132 to 681 days) after a single procedure, FIRM-guided cases had higher freedom from AF (82.4% vs. 44.9%; p < 0.001) after a single procedure than FIRM-blinded cases with rigorous, often implanted, electrocardiography monitoring. Adverse events did not differ between groups.


CONCLUSIONS
Localized electrical rotors and focal impulse sources are prevalent sustaining mechanisms for human AF. FIRM ablation at patient-specific sources acutely terminated or slowed AF, and improved outcome. These results offer a novel mechanistic framework and treatment paradigm for AF. (Conventional Ablation for Atrial Fibrillation With or Without Focal Impulse and Rotor Modulation [CONFIRM]; NCT01008722).
When nouns and verbs degrade: Facilitating communication in semantic dementia

This article may be used for research, teaching, and private study purposes. Any substantial or systematic reproduction, redistribution, reselling, loan, sub-licensing, systematic supply, or distribution in any form to anyone is expressly forbidden. The publisher does not give any warranty express or implied or make any representation that the contents will be complete or accurate or up to date. The accuracy of any instructions, formulae, and drug doses should be independently verified with primary sources. The publisher shall not be liable for any loss, actions, claims, proceedings, demand, or costs or damages whatsoever or howsoever caused arising directly or indirectly in connection with or arising out of the use of this material. Background: Little is known about how to maintain communicative effectiveness in semantic dementia as the disease progresses from impairment in word retrieval to a loss of conceptual knowledge. Aim: The purpose of this study is twofold. The first objective is to characterise communicative effectiveness using a modified framework derived from Chapman and Ulatowska (1997) that integrates two components: codification of ideas (falling on a continuum from verbal to nonverbal and generative to automatic forms) and functions of communication (imaginative, heuristic, informative, personal, interactional, regulatory , and instrumental). The second objective is to outline principles of a discourse intervention that focuses on communicative effectiveness. Method & Procedures: The participant was Mr Bobby V, a man with semantic dementia. His communication abilities were characterised at diagnosis and 24 months later using the framework of communicative effectiveness, based on discourse samples, clinical observation, and caregiver report. From the time of diagnosis, Bobby V received discourse intervention, which focused on maintaining his communication abilities using all available communication resources. We outline principles of discourse intervention in semantic dementia based on our experience of delivering individual and group intervention to Bobby V. Outcomes and Results: The communicative effectiveness framework described here could be used to characterise communication skills, set therapy goals, and monitor progress in semantic dementia. Discourse intervention likely facilitated Bobby V's continued success in maintaining communication despite progressive loss of nouns and verbs. Conclusions: Targeting conversational effectiveness in terms of communicative functions offers a promising and ecologically valuable intervention for people with semantic dementia, as it allows individuals with this form of dementia to connect meaningfully with people in their immediate surroundings well into the later stages of the disease.
Analgesic and anti-inflammatory activities of Citrus aurantium L. blossoms essential oil (neroli): involvement of the nitric oxide/cyclic-guanosine monophosphate pathway

The analgesic and anti-inflammatory properties of Citrus aurantium L. blossoms essential oil (neroli) were investigated in mice and rats. The analgesic activity of neroli was assessed by acetic acid-induced writhing and Eddy’s hot plate methods, while acute and chronic anti-inflammatory effects were investigated by inflammatory paw edema in rat and the cotton pellet-induced granuloma tissue model, respectively. Mechanistic studies were conducted using L-nitro arginine methyl ester (L-NAME), an inhibitor of NO synthase. Neroli significantly decreased the number of acetic acid-induced writhes in mice compared to animals that received vehicle only. Also, it exhibited a central analgesic effect, as evidenced by a significant increase in reaction time in the hot plate method. The oil also significantly reduced carrageenan-induced paw edema in rats. The inhibitory activity of neroli (especially at 40 mg/kg) was found to be very close to the standard drug, diclofenac sodium (50 mg/kg). In cotton pellet-induced granuloma, neroli was effective regarding the transudate and granuloma formation amount. Neroli was analyzed by gas chromatography (GC) and gas chromatography–mass spectrometry (GC–MS) and twenty-three constituents, representing 91.0 % of the oil, were identified. The major components of neroli were characterized as linalool (28.5 %), linalyl acetate (19.6 %), nerolidol (9.1 %), E,E-farnesol (9.1 %), α-terpineol (4.9 %), and limonene (4.6 %), which might be responsible for these observed activities. The results suggest that neroli possesses biologically active constituent(s) that have significant activity against acute and especially chronic inflammation, and have central and peripheral antinociceptive effects which support the ethnomedicinal claims of the use of the plant in the management of pain and inflammation.
The development of arithmetical abilities.

BACKGROUND
Arithmetical skills are essential to the effective exercise of citizenship in a numerate society. How these skills are acquired, or fail to be acquired, is of great importance not only to individual children but to the organisation of formal education and its role in society.


METHOD
The evidence on the normal and abnormal developmental progression of arithmetical abilities is reviewed; in particular, evidence for arithmetical ability arising from innate specific cognitive skills (innate numerosity) vs. general cognitive abilities (the Piagetian view) is compared.


RESULTS
These include evidence from infancy research, neuropsychological studies of developmental dyscalculia, neuroimaging and genetics. The development of arithmetical abilities can be described in terms of the idea of numerosity -- the number of objects in a set. Early arithmetic is usually thought of as the effects on numerosity of operations on sets such as set union. The child's concept of numerosity appears to be innate, as infants, even in the first week of life, seem to discriminate visual arrays on the basis of numerosity. Development can be seen in terms of an increasingly sophisticated understanding of numerosity and its implications, and in increasing skill in manipulating numerosities. The impairment in the capacity to learn arithmetic -- dyscalculia -- can be interpreted in many cases as a deficit in the concept in the child's concept of numerosity. The neuroanatomical bases of arithmetical development and other outstanding issues are discussed.


CONCLUSIONS
The evidence broadly supports the idea of an innate specific capacity for acquiring arithmetical skills, but the effects of the content of learning, and the timing of learning in the course of development, requires further investigation.
Elevations of FosB in the nucleus accumbens during forced cocaine abstinence correlate with divergent changes in reward function

Dysregulation of hedonic processing, in which seeking of drug reward becomes more desirable than seeking natural rewards, like food, sex, and novelty, is a consequence of chronic drug exposure and potentially leads to escalating drug usage and addiction. Here, we investigated the effects of chronic cocaine treatment (10 days of escalating doses of cocaine, 10-30 mg/kg) and multiple forced abstinence periods (2, 3 or 5 weeks) on the acute rewarding properties of either cocaine (10 mg/kg) or novel-objects using the conditioned place preference procedure. Following all cocaine withdrawal periods, cocaine preference was significantly elevated while novel object preference was abolished compared with saline-treated rats. At the earliest withdrawal period, these behavioral changes were accompanied by elevations in FosB-like immunoreactive staining in the basolateral amygdala (BLA) and nucleus accumbens shell (NAc-Sh) and core (NAc-C). FosB staining in all three brain areas correlated positively with cocaine preference, but negatively with novelty preference. After 5 weeks of withdrawal, FosB staining was only elevated in the NAc-Sh and again correlated positively with elevated cocaine preference but negatively with decreased novelty preference. These data indicate that alterations in the expression of FosB-like transcription factors in the NAc can predict the dysregulation of hedonic processing that occurs during protracted withdrawal from cocaine.