LLukas22/scidocs huggingface dataset:
Use of an activity monitor to detect response to treatment in dogs with osteoarthritis.

OBJECTIVE
To determine whether an activity monitor (AM) could be used to detect changes in activity in dogs with osteoarthritis treated with carprofen or a placebo.


DESIGN
Randomized controlled trial.


ANIMALS
70 dogs with no clinically important abnormalities other than osteoarthritis for which they were not currently being treated.


PROCEDURES
Dogs wore an AM continuously for 21 days. On days 8 through 21, the dogs were treated with carprofen (n = 35) or a placebo (35). Total activity counts for days 1 through 7 (baseline) were compared with total activity counts for days 15 through 21 (endpoint). The change in total activity count from baseline to endpoint was assessed within each treatment group as well as between groups. Linear regression analysis was performed to test for an association between treatment and percentage change in activity counts while controlling for other variables.


RESULTS
For placebo-treated dogs, median baseline total activity count was not significantly different from median endpoint total activity count (1,378,408 vs 1,310,112, respectively). For dogs receiving carprofen, there was a significant increase in median activity count from baseline to endpoint (1,276,427 vs 1,374,133). When age and baseline activity counts were controlled for, dogs in the carpofen-treated group had a 20% increase in activity counts, compared with placebo-treated dogs (95% confidence interval, 10% to 26%).


CONCLUSIONS AND CLINICAL RELEVANCE
Results suggested that the AM used in the present study may be a valid outcome assessment tool for documenting improved activity associated with treatment in dogs with osteoarthritis.
An Assistant Interface to Design and Produce a Pop-Up Card

This article describes an assistant interface to design and produce pop-up cards. A pop-up card is a piece of folded paper from which a three-dimensional structure pops up when opened. The authors propose an interface to assist the user in the design and production of a pop-up card. During the design process, the system examines whether the parts protrude from the card or whether the parts collide with one another when the card is closed. The user can concentrate on the design activity because the error occurrence and the error resolution are continuously fed to the user in real time. The authors demonstrate the features of their system by creating two pop-up card examples and perform an informal preliminary user study, showing that automatic protrusion and collision detection are effective in the design process. DOI: 10.4018/jcicg.2010070104 International Journal of Creative Interfaces and Computer Graphics, 1(2), 40-50, July-December 2010 41 Copyright © 2010, IGI Global. Copying or distributing in print or electronic forms without written permission of IGI Global is prohibited. start over from the beginning. This process requires a lot of time, energy, and paper. Design and simulation in a computer help both nonprofessionals and professionals to design a pop-up card, eliminate the boring repetition, and save time. Glassner (1998, 2002) proposed methods for designing a pop-up card on a computer. He introduced several simple pop-up mechanisms and described how to use these mechanisms, how to simulate the position of vertices as an intersecting point of three spheres, how to check whether the structure sticks out beyond the cover or if a collision occurs during opening, and how to generate templates. His work is quite useful in designing simple pop-up cards. In this article, we build on Glassner’s pioneering work and introduce several innovative aspects. We add two new mechanisms based on the V-fold: the box and the cube. We present a detailed description of the interface for design, which Glassner did not describe in any detail. In addition, our system provides real-time error detection feedback during editing operations by examining whether parts protrude from the card when closed or whether they collide with one another during opening and closing. Finally, we report on an informal preliminary user study of our system involving four inexperienced users.
Prediction of Transfusions After Isolated Coronary Artery Bypass Grafting Surgical Procedures.

BACKGROUND
Although blood transfusions are common and have been associated with adverse sequelae after cardiac surgical procedures, few contemporaneous models exist to support clinical decision making. This study developed a preoperative clinical decision support tool to predict perioperative red blood cell transfusions in the setting of isolated coronary artery bypass grafting.


METHODS
We performed a multicenter, observational study of 20,377 patients undergoing isolated coronary artery bypass grafting among patients at 39 hospitals participating in the Michigan Society of Thoracic and Cardiovascular Surgeons Quality Collaborative's PERFusion measures and outcomes (PERForm) registry between 2011 and 2015. Candidates' preoperative risk factors were identified based on previous work and clinical input. The study population was randomly divided into a 70% development sample and a 30% validation sample. A generalized linear mixed-effect model was developed to predict perioperative red blood cell transfusion. The model's performance was assessed for calibration and discrimination. Sensitivity analysis was performed to assess the robustness of the model in different clinical subgroups.


RESULTS
Transfusions occurred in 36.8% of patients. The final regression model included 16 preoperative variables. The correlation between the observed and expected transfusions was 1.0. The risk prediction model discriminated well (receiver operator characteristic [ROC]development, 0.81; ROCvalidation, 0.82) and had satisfactory calibration (correlation between observed and expected rates was r = 1.00). The model performance was confirmed across medical centers and clinical subgroups.


CONCLUSIONS
Our risk prediction model uses 16 readily obtainable preoperative variables. This model, which provides a patient-specific estimate of the need for transfusion, offers clinicians a guide for decision making and evaluating the effectiveness of blood management strategies.
Accuracy of Computed Tomographic Angiography and Single-Photon Emission Computed Tomography-Acquired Myocardial Perfusion Imaging for the Diagnosis of Coronary Artery Disease.

BACKGROUND
Establishing the diagnosis of coronary artery disease (CAD) in symptomatic patients allows appropriately allocating preventative measures. Single-photon emission computed tomography (CT)-acquired myocardial perfusion imaging (SPECT-MPI) is frequently used for the evaluation of CAD, but coronary CT angiography (CTA) has emerged as a valid alternative.


METHODS AND RESULTS
We compared the accuracy of SPECT-MPI and CTA for the diagnosis of CAD in 391 symptomatic patients who were prospectively enrolled in a multicenter study after clinical referral for cardiac catheterization. The area under the receiver operating characteristic curve was used to evaluate the diagnostic accuracy of CTA and SPECT-MPI for identifying patients with CAD defined as the presence of ≥1 coronary artery with ≥50% lumen stenosis by quantitative coronary angiography. Sensitivity to identify patients with CAD was greater for CTA than SPECT-MPI (0.92 versus 0.62, respectively; P<0.001), resulting in greater overall accuracy (area under the receiver operating characteristic curve, 0.91 [95% confidence interval, 0.88-0.94] versus 0.69 [0.64-0.74]; P<0.001). Results were similar in patients without previous history of CAD (area under the receiver operating characteristic curve, 0.92 [0.89-0.96] versus 0.67 [0.61-0.73]; P<0.001) and also for the secondary end points of ≥70% stenosis and multivessel disease, as well as subgroups, except for patients with a calcium score of ≥400 and those with high-risk anatomy in whom the overall accuracy was similar because CTA's superior sensitivity was offset by lower specificity in these settings. Radiation doses were 3.9 mSv for CTA and 9.8 for SPECT-MPI (P<0.001).


CONCLUSIONS
CTA is more accurate than SPECT-MPI for the diagnosis of CAD as defined by conventional angiography and may be underused for this purpose in symptomatic patients.


CLINICAL TRIAL REGISTRATION
URL: http://www.clinicaltrials.gov. Unique identifier: NCT00934037.
Socioeconomic and Racial/Ethnic Disparities in Cancer Mortality, Incidence, and Survival in the United States, 1950–2014: Over Six Decades of Changing Patterns and Widening Inequalities

We analyzed socioeconomic and racial/ethnic disparities in US mortality, incidence, and survival rates from all-cancers combined and major cancers from 1950 to 2014. Census-based deprivation indices were linked to national mortality and cancer data for area-based socioeconomic patterns in mortality, incidence, and survival. The National Longitudinal Mortality Study was used to analyze individual-level socioeconomic and racial/ethnic patterns in mortality. Rates, risk-ratios, least squares, log-linear, and Cox regression were used to examine trends and differentials. Socioeconomic patterns in all-cancer, lung, and colorectal cancer mortality changed dramatically over time. Individuals in more deprived areas or lower education and income groups had higher mortality and incidence rates than their more affluent counterparts, with excess risk being particularly marked for lung, colorectal, cervical, stomach, and liver cancer. Education and income inequalities in mortality from all-cancers, lung, prostate, and cervical cancer increased during 1979-2011. Socioeconomic inequalities in cancer mortality widened as mortality in lower socioeconomic groups/areas declined more slowly. Mortality was higher among Blacks and lower among Asian/Pacific Islanders and Hispanics than Whites. Cancer patient survival was significantly lower in more deprived neighborhoods and among most ethnic-minority groups. Cancer mortality and incidence disparities may reflect inequalities in smoking, obesity, physical inactivity, diet, alcohol use, screening, and treatment.
Continuous infusion of ceftazidime in critically ill patients undergoing continuous venovenous haemodiafiltration: pharmacokinetic evaluation and dose recommendation

INTRODUCTION
In seriously infected patients with acute renal failure and who require continuous renal replacement therapy, data on continuous infusion of ceftazidime are lacking. Here we analyzed the pharmacokinetics of ceftazidime administered by continuous infusion in critically ill patients during continuous venovenous haemodiafiltration (CVVHDF) in order to identify the optimal dosage in this setting.


METHOD
Seven critically ill patients were prospectively enrolled in the study. CVVHDF was performed using a 0.6 m2 AN69 high-flux membrane and with blood, dialysate and ultrafiltration flow rates of 150 ml/min, 1 l/hour and 1.5 l/hour, respectively. Based on a predicted haemodiafiltration clearance of 32.5 ml/min, all patients received a 2 g loading dose of ceftazidime, followed by a 3 g/day continuous infusion for 72 hours. Serum samples were collected at 0, 3, 15 and 30 minutes and at 1, 2, 4, 6, 8, 12, 24, 36, 48 and 72 hours; dialysate/ultrafiltrate samples were taken at 2, 8, 12, 24, 36 and 48 hours. Ceftazidime concentrations in serum and dialysate/ultrafiltrate were measured using high-performance liquid chromatography.


RESULTS
The mean (+/- standard deviation) elimination half-life, volume of distribution, area under the concentration-time curve from time 0 to 72 hours, and total clearance of ceftazidime were 4 +/- 1 hours, 19 +/- 6 l, 2514 +/- 212 mg/h per l, and 62 +/- 5 ml/min, respectively. The mean serum ceftazidime steady-state concentration was 33.5 mg/l (range 28.8-36.3 mg/l). CVVHDF effectively removed continuously infused ceftazidime, with a sieving coefficient and haemodiafiltration clearance of 0.81 +/- 0.11 and 33.6 +/- 4 mg/l, respectively.


CONCLUSION
We conclude that a dosing regimen of 3 g/day ceftazidime, by continuous infusion, following a 2 g loading dose, results in serum concentrations more than four times the minimum inhibitory concentration for all susceptible pathogens, and we recommend this regimen in critically ill patients undergoing CVVHDF.
Eruptive syringomas: unresponsiveness to oral isotretinoin.

Eruptive syringomas: unresponsiveness to oral isotretinoin A 22-year-old man of Egyptian origin was referred to our department due to exacerbation of pruritic pre-existing papular dermatoses. The skin lesions had been present since childhood. The family history was negative for a similar condition. The patient complained of exacerbation of the pruritus during physical activity under a hot climate and had moderate to severe pruritus during his work. Physical examination revealed multiple reddish-brownish smooth-surfaced, symmetrically distributed papules 2–4 mm in diameter on the patient’s trunk, neck, axillae, and limbs (Fig. 1). The rest of the physical examination was unremarkable. The Darier sign was negative. A skin biopsy was obtained from a representative lesion on the trunk. Histopathologic examination revealed a small, wellcircumscribed neoplasm confined to the upper dermis, composed of small solid and ductal structures relatively evenly distributed in a sclerotic collagenous stroma. The solid elements were of various shapes (round, oval, curvilinear, “comma-like,” or “tadpole-like”) (Fig. 2). These microscopic features and the clinical presentation were consistent with the diagnosis of eruptive syringomas. Our patient was treated with a short course of oral antihistamines without any effect and subsequently with low-dose isotretinoin (10 mg/day) for 5 months. No improvement of the skin eruption was observed while cessation of the pruritus was accomplished. Syringoma is a common adnexal tumor with differentiation towards eccrine acrosyringium composed of small solid and ductal elements embedded in a sclerotic stroma and restricted as a rule to the upper to mid dermis, usually presenting clinically as multiple lesions on the lower eyelids and cheeks of adolescent females. A much less common variant is the eruptive or disseminated syringomas, which involve primarily young women. Eruptive syringomas are characterized by rapid development during a short period of time of hundreds of small (1–5 mm), ill-defined, smooth surfaced, skin-colored, pink, yellowish, or brownish papules typically involving the face, trunk, genitalia, pubic area, and extremities but can occur principally in any site where eccrine glands are found. The pathogenesis of eruptive syringoma remains unclear. Some authors have recently challenged the traditional notion that eruptive syringomas are neoplastic lesions. Chandler and Bosenberg presented evidence that eruptive syringomas result from autoimmune destruction of the acrosyringium and proposed the term autoimmune acrosyringitis with ductal cysts. Garrido-Ruiz et al. support the theory that eruptive syringomas may represent a hyperplastic response of the eccrine duct to an inflammatory reaction. In a recent systematic review by Williams and Shinkai the strongest association of syringomas was with Down’s syndrome (183 reported cases, 22.2%). Syringomas are also associated with diabetes mellitus (17 reported cases, 2.1%), Ehlers–Danlos
Motivational deficits and cognitive test performance in schizophrenia.

IMPORTANCE
Motivational and cognitive deficits are core features of schizophrenia, both closely linked with functional outcomes. Although poor effort and decreased motivation are known to affect performance on cognitive tests, the extent of this relationship is unclear in patients with schizophrenia.


OBJECTIVE
To evaluate the association between intrinsic motivation and cognitive test performance in patients with schizophrenia.


DESIGN, SETTING, AND PARTICIPANTS
Cross-sectional and 6-month prospective follow-up study performed at 57 sites in the United States, including academic and community medical treatment centers, participating in the Clinical Antipsychotic Trials of Intervention Effectiveness study. The primary sample included 431 stable patients with a DSM-IV diagnosis of schizophrenia currently receiving a stable medication regimen.


INTERVENTIONS
Cognitive performance and intrinsic motivation were evaluated using a comprehensive neuropsychological test battery and a derived measure from the Heinrichs-Carpenter Quality of Life Scale, respectively. Symptom severity and functional status were also assessed.


MAIN OUTCOMES AND MEASURES
The primary outcome variable was global neurocognition. Individual domains of cognition were also evaluated for their association with motivation.


RESULTS
Level of intrinsic motivation was significantly and positively correlated with global cognitive test performance, a relationship that held for each domain of cognition evaluated (correlation range, 0.20-0.34; P < .001). This association was found to be reliable after statistically accounting for positive, negative, depressive, and overall symptom severity (P < .05) and after accounting for community functioning (P < .001). The relationship between motivation and cognitive performance also remained significant after controlling for antipsychotic dose (P < .05). Prospective increase in motivation during the 6-month follow-up was also found to be significantly related to improvement in global cognitive performance (P < .05).


CONCLUSIONS AND RELEVANCE
The present findings provide strong support for a robust and reliable relationship between motivation and cognitive performance and suggest that test performance is not purely a measure of ability. Future studies assessing cognition in patients with schizophrenia should consider potential moderating variables such as effort and motivation. Implications for the assessment and interpretation of cognitive impairment based on neuropsychological test measures in schizophrenia are discussed, especially in the case of clinical trials for cognition-enhancing treatments.


TRIAL REGISTRATION
clinicaltrials.gov Identifier: NCT00014001.
An online HDP-HMM for joint action segmentation and classification in motion capture data

Since its inception, action recognition research has mainly focused on recognizing actions from closed, predefined sets of classes. Conversely, the problem of recognizing actions from open, possibly incremental sets of classes is still largely unexplored. In this paper, we propose a novel online method based on the “sticky” hierarchical Dirichlet process and the hidden Markov model [11, 5]. This approach, labelled as the online HDP-HMM, provides joint segmentation and classification of actions while a) processing the data in an online, recursive manner, b) discovering new classes as they occur, and c) adjusting its parameters over the streaming data. In a set of experiments, we have applied the online HDP-HMM to recognize actions from motion capture data from the TUM kitchen dataset, a challenging dataset of manipulation actions in a kitchen [12]. The results show significant accuracy in action classification, time segmentation and determination of the number of action classes.
Mondor's disease of penis: a forgotten disease.

BACKGROUND
Mondor's disease of penis is an uncommon genital condition involving the penile sulcus in a circumferential manner. Although this disorder is almost always self limited, it is associated with considerable psychological stress and sexual disharmony.


METHODS
All patients attending the sexually transmitted disease clinic during 1991-2003 were examined for evidence of Mondor's disease of penis. Detailed history and clinical findings were recorded in a specially designed proforma. Histopathological examination and staining with CD31 and CD34 monoclonal antibodies was also done in 11 patients.


RESULTS
18 out of 1296 patients attending the sexually transmitted diseases (STD) clinic during the study period were found to have penile Mondor's disease, giving an incidence of 1.39%. 17 patients had history of one or more episodes of STDs. Histopathological specimens showed prominent vessels with plump endothelial cells and thickened blood vessel walls. The occasional vessel showed complete occlusion of its lumen.


CONCLUSIONS
In our study we did not find any evidence of lymphatic involvement. Non-lymphatic vessels, mainly veins, were predominantly involved. In our opinion Mondor's phlebitis of penis or Mondor's disease of penis are better terms to describe the condition rather than non-venereal sclerosing lymphangitis.
Evolution of faulting and paleo-stress field within the Ottawa graben, Canada

Abstract We relate families of faults in the Ottawa graben to periods in the tectonic evolution of eastern North America. The Ottawa graben is a seismically active structure that coincides with a 55 km wide topographic depression extending from near Montreal through Ottawa. It is part of the St. Lawrence rift system that also includes the seismically active Saguenay graben. The Cambrian to Ordovician sedimentary rocks that overlie Grenvillian basement rocks in the Ottawa area are cut by several generations of brittle faults. Relative ages of faults and associated structures are determined, or inferred, from field studies of key outcrops. Three periods of faulting are defined. The orientations of the paleo-stress fields associated with each period are modelled using fault and fault surface lineations orientation data. The oldest generation of faults (D 1 ) formed in response to a stress field in which the greatest principal stress ( σ 1 ) was horizontal and oriented NW. D 2 and D 3 occurred when σ 1 was oriented WNW and SW, respectively. Hence the paleo-stress field underwent a counterclockwise rotation from D 1 to D 3 . The D 2 and D 3 periods involved the reactivation of faults and the development of new faults. D 1 structures are kinematically congruent with the compressional direction associated with the closing of the Iapetus Ocean during Paleozoic time. Emplacement of Cretaceous carbonatite dykes coincided with D 2 , which occurred during the Mesozoic when the stress regime was associated with the opening of the Atlantic Ocean. The relative timing of these structures supports both Paleozoic and Mesozoic ages of mineralization events within the Ottawa graben. D 3 structures are consistent with the post-Cretaceous stress field in eastern North America. Recent seismicity within the Ottawa graben may involve reactivations of faults belonging to the families identified in this paper.
Insulin infusion improves neutrophil function in diabetic cardiac surgery patients.

UNLABELLED
Diabetic patients are at increased risk of wound infection after major surgery, but the effect of perioperative glucose control on postoperative wound infection rates after surgery is uncertain. We tested the effect of an insulin infusion on perioperative neutrophil function in diabetic patients scheduled for coronary artery bypass surgery. Participants (n = 26) were randomly allocated to receive either aggressive insulin therapy (AIT) or standard insulin therapy (SIT) during surgery. Blood was drawn for neutrophil testing before surgery, 1 h after the completion of cardiopulmonary bypass, and on the first postoperative day. Neutrophil phagocytic activity decreased to 75% of baseline activity in the AIT group and to 47% of baseline activity in the SIT group (P < 0.05 between groups). No important differences in neutrophil antibody-dependent cell cytotoxicity were found. This study documents a potentially beneficial effect of continuous insulin therapy in diabetic patients who require major surgery.


IMPLICATIONS
A continuous insulin infusion and glucose control during surgery improves white cell function in diabetic patients and may increase resistance to infection after surgery.