LLukas22/scidocs huggingface dataset:
Caffeine & Health : Clarifying The Controversies IFIC

is one of the most comprehensively studied ingredients in the food supply. Yet, despite our considerable knowledge of caffeine and centuries of safe consumption in foods and beverages, questions and misperceptions about the potential health effects associated with caffeine persist. This Review provides up-to-date information on caffeine, examines its safety and summarizes the most recent key research conducted on caffeine and health. EXECUTIVE SUMMARY Caffeine is added to soft drinks as a flavoring agent; it imparts a bitterness that modifies the flavors of other components, both sour and sweet. Although there has been controversy as to its effectiveness in this role, a review of the literature suggests that caffeine does, in fact, contribute to the sensory appeal of soft drinks. [Drewnowski, 2001] Moderate intake of 300 mg/day (about three cups of coffee per day) of caffeine does not cause adverse health effects in healthy adults, although some groups, including those with hypertension and the elderly, may be more vulnerable. Also, regular consumers of coffee and other caffeinated beverages may experience some undesirable, but mild, short-lived symptoms if they stop consuming caffeine , particularly if the cessation is abrupt. However, there is little evidence of health risks of caffeine consumption. In fact, some evidence of health benefits exists for adults who consume moderate amounts of caffeine. Caffeine consumption may help reduce the risk of several chronic diseases, including diabetes, Parkinson's disease, liver disease, and colorectal cancer, as well as improve immune function. Large prospective cohort studies in the Netherlands, Finland, Sweden, and the United States have found caffeine consumption is associated with reduced risk of developing type 2 diabetes, although the mechanisms are unclear. Several other cohort studies have found that caffeine consumption from coffee and other beverages decreases the risk of Parkinson's Disease in men, as well as in women who have never used post-menopausal hormone replacement therapy. Epidemiological studies also suggest that coffee consumption may decrease the risk of liver injury, cirrhosis and hepatocellular carcinoma (liver cancer), although the reasons for these results have not been determined. In addition, coffee consumption appears to reduce the risk of colorectal cancer, but this has not generally been confirmed in prospective cohort studies. An anti-inflammatory effect has also been observed in a number of studies on caffeine's impact on the immune system. Most studies have found that caffeine consumption does not significantly increase the risk of coronary heart disease (CHD) or stroke. …
Phase 1 b Study of Pegylated Interferon Lambda 1 With or Without Ribavirin in Patients with Chronic Genotype 1 Hepatitis C Virus Infection

Interferon lambda 1 (IFN-k1) is a type III IFN that produces intracellular responses similar to those of IFN-a but in fewer cell types because of differences in the receptor distribution pattern, and this could potentially result in an improved safety profile. This was an open-label three-part study of patients with chronic hepatitis C virus (HCV) genotype 1 infection. Part 1 evaluated single-agent pegylated interferon lambda (PEG-IFN-k) at 1.5 or 3.0 lg/kg administered every 2 weeks or weekly for 4 weeks in patients who had relapsed after previous IFN-a-based treatment. Part 2 evaluated weekly doses of PEGIFN-k ranging from 0.5 to 2.25 lg/kg in combination with ribavirin (RBV) for 4 weeks in treatment-relapse patients. Part 3 evaluated weekly PEG-IFN-k at 1.5 lg/kg in combination with RBV for 4 weeks in treatment-naive patients. Fifty-six patients were enrolled: 24 patients in part 1, 25 patients in part 2, and 7 patients in part 3. Antiviral activity was observed at all PEG-IFN-k dose levels (from 0.5 to 3.0 lg/kg). Two of seven treatmentnaive patients (29%) achieved rapid virological response. Treatment was well tolerated with minimal flu-like symptoms and no significant hematologic changes other than RBV-associated decreases in hemoglobin. The most common adverse events were fatigue (29%), nausea (12%), and myalgia (11%). Six patients experienced increases in aminotransferases that met protocol-defined criteria for dose-limiting toxicity (DLT) or temporarily holding therapy with PEG-IFN-k. Most DLT occurred in patients with high PEGIFN-k exposure. Conclusion: Weekly PEG-IFN-k with or without daily RBV for 4 weeks is well tolerated with minimal adverse events and hematologic effects and is associated with clear antiviral activity across a broad range of doses in patients with chronic HCV. (HEPATOLOGY 2010;00:000-000)
Citation pattern matching algorithms for citation-based plagiarism detection: greedy citation tiling, citation chunking and longest common citation sequence

Plagiarism Detection Systems have been developed to locate instances of plagiarism e.g. within scientific papers. Studies have shown that the existing approaches deliver reasonable results in identifying copy&paste plagiarism, but fail to detect more sophisticated forms such as paraphrased plagiarism, translation plagiarism or idea plagiarism. The authors of this paper demonstrated in recent studies that the detection rate can be significantly improved by not only relying on text analysis, but by additionally analyzing the citations of a document. Citations are valuable language independent markers that are similar to a fingerprint. In fact, our examinations of real world cases have shown that the order of citations in a document often remains similar even if the text has been strongly paraphrased or translated in order to disguise plagiarism.
 This paper introduces three algorithms and discusses their suitability for the purpose of citation-based plagiarism detection. Due to the numerous ways in which plagiarism can occur, these algorithms need to be versatile. They must be capable of detecting transpositions, scaling and combinations in a local and global form. The algorithms are coined Greedy Citation Tiling, Citation Chunking and Longest Common Citation Sequence. The evaluation showed that if these algorithms are combined, common forms of plagiarism can be detected reliably.
A prospective comparison of cardiac rehabilitation enrollment following automatic vs usual referral.

OBJECTIVE
Cardiac rehabilitation remains grossly under-utilized despite its proven benefits. This study prospectively compared verified cardiac rehabilitation enrollment following automatic vs usual referral, postulating that automatic referral would result in significantly greater enrollment for cardiac rehabilitation.


DESIGN
Prospective controlled multi-center study.


PATIENTS AND METHODS
A consecutive sample of 661 patients with acute coronary syndrome treated at 2 acute care centers (75% response rate) were recruited, one site with automatic referral via a computerized prompt and the other with a usual referral strategy at the physician's discretion. Cardiac rehabilitation referral was discerned in a mailed survey 9 months later (n = 506; 84% retention), and verified with 24 cardiac rehabilitation sites to which participants were referred.


RESULTS
A total of 124 (52%) participants enrolled in cardiac rehabilitation following automatic referral, vs 84 (32%) following usual referral (p < 0.001). Automatically referred participants were more likely to be referred from an in- patient unit (p < 0.01), and to be referred in a shorter time period (p < 0.001). Logistic regression analyses revealed that, after controlling for sociodemographic characteristics and case-mix, automatically referred participants were significantly more likely to enroll in cardiac rehabilitation (odds ratio = 2.1; 95% confidence interval 1.4-3.3) than controls.


CONCLUSION
Automatic referral resulted in over 50% verified cardiac rehabilitation enrollment; 2 times more than usual referral. It also significantly reduced utilization delays to less than one month.
Developing a tool to measure satisfaction among health professionals in sub-Saharan Africa

BACKGROUND
In sub-Saharan Africa, lack of motivation and job dissatisfaction have been cited as causes of poor healthcare quality and outcomes. Measurement of health workers' satisfaction adapted to sub-Saharan African working conditions and cultures is a challenge. The objective of this study was to develop a valid and reliable instrument to measure satisfaction among health professionals in the sub-Saharan African context.


METHODS
A survey was conducted in Senegal and Mali in 2011 among 962 care providers (doctors, midwives, nurses and technicians) practicing in 46 hospitals (capital, regional and district). The participation rate was very high: 97% (937/962). After exploratory factor analysis (EFA), construct validity was assessed through confirmatory factor analysis (CFA). The discriminant validity of our subscales was evaluated by comparing the average variance extracted (AVE) for each of the constructs with the squared interconstruct correlation (SIC), and finally for criterion validity, each subscale was tested with two hypotheses. Two dimensions of reliability were assessed: internal consistency with Cronbach's alpha subscales and stability over time using a test-retest process.


RESULTS
Eight dimensions of satisfaction encompassing 24 items were identified and validated using a process that combined psychometric analyses and expert opinions: continuing education, salary and benefits, management style, tasks, work environment, workload, moral satisfaction and job stability. All eight dimensions demonstrated significant discriminant validity. The final model showed good performance, with a root mean square error of approximation (RMSEA) of 0.0508 (90% CI: 0.0448 to 0.0569) and a comparative fit index (CFI) of 0.9415. The concurrent criterion validity of the eight dimensions was good. Reliability was assessed based on internal consistency, which was good for all dimensions but one (moral satisfaction < 0.70). Test-retest showed satisfactory temporal stability (intra class coefficient range: 0.60 to 0.91).


CONCLUSIONS
Job satisfaction is a complex construct; this study provides a multidimensional instrument whose content, construct and criterion validities were verified to ensure its suitability for the sub-Saharan African context. When using these subscales in further studies, the variability of the reliability of the subscales should be taken in to account for calculating the sample sizes. The instrument will be useful in evaluative studies which will help guide interventions aimed at improving both the quality of care and its effectiveness.
Android Based Vehicle Anti-Theft Alarm and Tracking System in Hand-Held Communication Terminal

With the rapid development of China's automobile industry, the number of cars is increasing rapidly. Automobile has developed into an important means of transportation for people. However, while people are enjoying the convenience and speed brought by the vehicle travel, the theft of vehicles is causing more and more concern. Owing to the importance of vehicles safety, how to prevent vehicles from being stolen is becoming a hot topic in the field of artificial intelligence. In this paper, a vehicle anti-theft alarm and tracking system based on Android operating system in hand-held communication terminal is designed and developed. By using the built-in sensors of the terminal based on Android Operating System (OS), such as a smart phone, the abnormal information of a vehicle will be sent to the owner's smart phone through communication network. In this way, the long-distance remote alarm can be realized. In addition, the usage of the positioning function of GPS or communication base station makes vehicle location tracking into possible. Finally, a demo system is performed and it can effectively perform vehicle anti-theft alarm and tracking.
Portfolio Selection in Stochastic Environments

In this article, I explicitly solve dynamic portfolio choice problems, up to the solution of an ordinary differential equation (ODE), when the asset returns are quadratic and the agent has a constant relative risk aversion (CRRA) coefficient. My solution includes as special cases many existing explicit solutions of dynamic portfolio choice problems. I also present three applications that are not in the literature. Application 1 is the bond portfolio selection problem when bond returns are described by ‘‘quadratic term structure models.’’ Application 2 is the stock portfolio selection problem when stock return volatility is stochastic as in Heston model. Application 3 is a bond and stock portfolio selection problem when the interest rate is stochastic and stock returns display stochastic volatility. (JEL G11)
Hip muscle imbalance and low back pain in athletes: influence of core strengthening.

PURPOSE
The influence of a core-strengthening program on low back pain (LBP) occurrence and hip strength differences were studied in NCAA Division I collegiate athletes.


METHODS
In 1998, 1999, and 2000, hip strength was measured during preparticipation physical examinations and occurrence of LBP was monitored throughout the year. Following the 1999-2000 preparticipation physicals, all athletes began participation in a structured core-strengthening program, which emphasized abdominal, paraspinal, and hip extensor strengthening. Incidence of LBP and the relationship with hip muscle imbalance were compared between consecutive academic years.


RESULTS
After incorporation of core strengthening, there was no statistically significant change in LBP occurrence. Side-to-side extensor strength between athletes participating in both the 1998-1999 and 1999-2000 physicals were no different. After core strengthening, the right hip extensor was, on average, stronger than that of the left hip extensor (P = 0.0001). More specific gender differences were noted after core strengthening. Using logistic regression, female athletes with weaker left hip abductors had a more significant probability of requiring treatment for LBP (P = 0.009)


CONCLUSION
The impact of core strengthening on collegiate athletes has not been previously examined. These results indicated no significant advantage of core strengthening in reducing LBP occurrence, though this may be more a reflection of the small numbers of subjects who actually required treatment. The core program, however, seems to have had a role in modifying hip extensor strength balance. The association between hip strength and future LBP occurrence, observed only in females, may indicate the need for more gender-specific core programs. The need for a larger scale study to examine the impact of core strengthening in collegiate athletes is demonstrated.
Why Do Customer Relationship Management Applications Affect Customer Satisfaction?

This research evaluates the effect of customer relationship management (CRM) on customer knowledge and customer satisfaction. An analysis of archival data for a cross-section of U.S. firms shows that the use of CRM applications is positively associated with improved customer knowledge and improved customer satisfaction. This article also shows that gains in customer knowledge are enhanced when firms share their customer-related information with their supply chain partners.
Influence of biotic and abiotic elicitors on accumulation of hyoscyamine and scopolamine in root cultures of Datura metel L.

Leaf-derived root cultures of Datura metel L., established on B5 medium containing 1.2 μM IAA, were employed to study the influence of biotic (Aspergillus niger, Alternaria sp., Fusarium monoliforme and yeast extract) and abiotic (salicylic acid, AlCl3, CaCl2, NaCl and Na2SO4) elicitors on the growth and production of hyoscyamine and scopolamine, the medicinally important tropane alkaloids. The hyoscyamine and scopolamine contents in control root cultures were 1.39 mg/g dw and 0.069 mg/g dw, respectively. The highest hyoscyamine (4.35 mg/g dw) and scopolamine (0.28 mg/g dw) accumulation was obtained in cultures treated with 500 μM salicylic acid, followed by treatment with 0.75 g L yeast extract (3.17 mg/g dw hyoscyamine & 0.16 mg/g dw scopolamine) and 250 μM AlCl3 (2.49 mg/g dw hyoscyamine and 0.11 mg/g dw scopolamine).
Cancer incidence and mortality in China, 2014.

Background
National Central Cancer Registry of China (NCCRC) updated nationwide cancer statistics using population-based cancer registry data in 2014 collected from all available cancer registries.


Methods
In 2017, 449 cancer registries submitted cancer registry data in 2014, among which 339 registries' data met the criteria of quality control and were included in analysis. These cancer registries covered 288,243,347 population, accounting for about 21.07% of the national population in 2014. Numbers of nationwide new cancer cases and deaths were estimated using calculated incidence and mortality rates and corresponding national population stratified by area, sex, age group and cancer type. The world Segi's population was applied for age-standardized rates.


Results
A total of 3,804,000 new cancer cases were diagnosed, the crude incidence rate was 278.07/100,000 (301.67/100,000 in males, 253.29/100,000 in females) and the age-standardized incidence rate by world standard population (ASIRW) was 186.53/100,000. Calculated age-standardized incidence rate was higher in urban areas than in rural areas (191.6/100,000 vs. 179.2/100,000). South China had the highest cancer incidence rate while Southwest China had the lowest incidence rate. Cancer incidence rate was higher in female for population between 20 to 54 years but was higher in male for population younger than 20 years or over 54 years. A total of 2,296,000 cancer deaths were reported, the crude mortality rate was 167.89/100,000 (207.24/100,000 in males, 126.54/100,000 in females) and the age-standardized mortality rate by world standard population (ASMRW) was 106.09/100,000. Calculated age-standardized mortality rate was higher in rural areas than in urban areas (110.3/100,000 vs. 102.5/100,000). East China had the highest cancer mortality rate while North China had the lowest mortality rate. The mortality rate in male was higher than that in female. Common cancer types and major causes of cancer death differed between age group and sex.


Conclusions
Heavy cancer burden and its disparities between area, sex and age group pose a major challenge to public health in China. Nationwide cancer registry plays a crucial role in cancer prevention and control.
CNTFET based Logic Circuits : A Brief Review

In this paper at first a brief review of carbon nanotubes (CNTs) is given and then an extensive survey of CNTFET (carbon nanotube field effect transistor) based logic circuits are discussed with the most recently reported CNTFET logic circuits. Keywords— MOSFETs, technology scaling, CNTFETs, carbon nanotubes (CNT), chiriality.
Positioning with Bluetooth

This paper presents an evaluation of Bluetooth positioning in a general positioning platform. Proceeding the evaluation a Bluetooth based positioning system was implemented in order to complement the theoretical evaluation with em-
Optimizing Strategic Safety Stock Placement in Supply Chains

Manufacturing managers face increasing pressure to reduce inventories across the supply chain. However, in complex supply chains, it is not always obviouswhere to hold safety stock to minimize inventory costs and provide a high level of service to the final customer. In this paper we develop a framework for modeling strategic safety stock in a supply chain that is subject to demand or forecast uncertainty. Key assumptions are that we can model the supply chain as a network, that each stage in the supply chain operates with a periodic-review base-stock policy, that demand is bounded, and that there is a guaranteed service time between every stage and its customers. We develop an optimization algorithm for the placement of strategic safety stock for supply chains that can be modeled as spanning trees. Our assumptions allow us to capture the stochastic nature of the problem and formulate it as a deterministic optimization. As a partial validation of the model, we describe its successful application by product flow teams at Eastman Kodak. We discuss how these flow teams have used the model to reduce finished goods inventory, target cycle time reduction efforts, and determine component inventories. We conclude with a list of needs to enhance the utility of the model. (Base-Stock Policy; Dynamic Programming Application;Multi-echelon Inventory System;Multi-Stage Supply-Chain Application; Safety Stock Optimization)
Sampling frequency and eye-tracking measures: how speed affects durations, latencies, and more

We use simulations to investigate the effect of sampling frequency on common dependent variables in eye-tracking. We identify two large groups of measures that behave differently, but consistently. The effect of sampling frequency on these two groups of measures are explored and simulations are performed to estimate how much data are required to overcome the uncertainty of a limited sampling frequency. Both simulated and real data are used to estimate the temporal uncertainty of data produced by low sampling frequencies. The aim is to provide easy-touse heuristics for researchers using eye-tracking. For example, we show how to compensate the uncertainty of a low sampling frequency with more data and postexperiment adjustments of measures. These findings have implications primarily for researchers using naturalistic setups where sampling frequencies typically are low.