LLukas22/scidocs huggingface dataset:
Heart rate variability during exercise performed below and above ventilatory threshold.

PURPOSE
To examine whether differences in heart rate variability (HRV) can distinguish sub- from supra-ventilatory-threshold exercise and whether the exercise duration at supra-threshold intensity alters cardiorespiratory synchronization.


METHODS
Beat-to-beat RR interval, VO2, VCO2, VE, and blood lactate concentration of 11 healthy well-trained young subjects were collected during two exercise tests: 1) a moderate-intensity test: 15 min performed below the power at ventilatory threshold (pVT); and 2) a heavy-intensity test: above pVT until exhaustion. Fast Fourier transform, smoothed pseudo Wigner-Ville distribution, and complex demodulation were applied to RR time series.


RESULTS
1) Moderate exercise shows a prevalence of low-frequency (LF) spectral energy compared with the high-frequency (HF) one (LF = 80 +/- 10% vs HF = 20 +/- 10%, P < 0.001), whereas the reverse is observed during heavy exercise (LF = 11 +/- 8% vs HF = 89 +/- 8%, P < 0.001). 2) During heavy exercise, the HF amplitude and the tidal volume (Vt) remained constant, whereas the breathing frequency (BF) increased (BF: 0.70 +/- 0.18 vs 0.93 +/- 0.31, P < 0.01) and mean RR decreased (342 +/- 15 vs 317 +/- 16, P < 0.01). Despite the RR series and the breathing signal remaining synchronized, HR/BF ratio decreased and stabilized at 3 RR for one breathing cycle, whatever the initial ratio.


CONCLUSION
1) HRV allows us to differentiate sub- from supra-ventilatory-threshold exercise and 2) exercise duration at supra-threshold intensity does not alter the cardiorespiratory synchronization.
Antagonistic Stiffness Optimization of Redundantly Actuated Parallel Manipulators in a Predefined Workspace

An optimization procedure regarding shape of usable workspace and antagonistic stiffness is developed for a redundantly actuated parallel manipulator. The kinematic parameters such as configuration of the mechanism and length of linkages are optimized to maximize and equal out antagonistic stiffness of the redundantly actuated manipulator when the shape of usable workspace is given as a rectangle. The proposed procedure is verified by simulation and experiment with a 2-DOF planar manipulator. In the experiment, the principal axes of displacements of ellipses are measured when the corresponding external forces are imposed on the end-effector. The simulation and experimental results show that the proposed procedure is valid for designing the redundantly actuated parallel manipulator with maximum antagonistic stiffness.
` p-Norm Multiple Kernel Learning

Learning linear combinations of multiple kernels is an appealing strategy when the right choice of features is unknown. Previous approaches to multiple kernel learning (MKL) promote sparse kernel combinations to support interpretability and scalability. Unfortunately, this `1-norm MKL is rarely observed to outperform trivial baselines in practical applications. To allow for robust kernel mixtures that generalize well, we extend MKL to arbitrary norms. We devise new insights on the connection between several existing MKL formulations and develop two efficient interleaved optimization strategies for arbitrary norms, that is `p-norms with p ≥ 1. This interleaved optimization is much faster than the commonly used wrapper approaches, as demonstrated on several data sets. A theoretical analysis and an experiment on controlled artificial data shed light on the appropriateness of sparse, non-sparse and `∞-norm MKL in various scenarios. Importantly, empirical applications of `p-norm MKL to three real-world problems from computational biology show that non-sparse MKL achieves accuracies that surpass the state-of-the-art. Data sets, source code to reproduce the experiments, implementations of the algorithms, and further information are available at http://doc.ml.tu-berlin.de/nonsparse_mkl/.
In vitro antibacterial activity of some plant essential oils

BACKGROUND
To evaluate the antibacterial activity of 21 plant essential oils against six bacterial species.


METHODS
The selected essential oils were screened against four gram-negative bacteria (Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus vulgaris) and two gram-positive bacteria Bacillus subtilis and Staphylococcus aureus at four different concentrations (1:1, 1:5, 1:10 and 1:20) using disc diffusion method. The MIC of the active essential oils were tested using two fold agar dilution method at concentrations ranging from 0.2 to 25.6 mg/ml.


RESULTS
Out of 21 essential oils tested, 19 oils showed antibacterial activity against one or more strains. Cinnamon, clove, geranium, lemon, lime, orange and rosemary oils exhibited significant inhibitory effect. Cinnamon oil showed promising inhibitory activity even at low concentration, whereas aniseed, eucalyptus and camphor oils were least active against the tested bacteria. In general, B. subtilis was the most susceptible. On the other hand, K. pneumoniae exhibited low degree of sensitivity.


CONCLUSION
Majority of the oils showed antibacterial activity against the tested strains. However Cinnamon, clove and lime oils were found to be inhibiting both gram-positive and gram-negative bacteria. Cinnamon oil can be a good source of antibacterial agents.
New zircon ages from the Tasiusarsuaq terrane, southern West Greenland

In the last three field seasons the Geological Survey of Denmark and Greenland (GEUS) has undertaken mapping in the south-eastern part of the Nuuk region in southern West Greenland, and here we present new zircon ages that help constrain the northern boundary of the Tasiusarsuaq terrane. The Archaean geology of the Nuuk region is commonly interpreted as a tectonic collage assembled through lateral accretion and collision of oceanic and continental slivers and blocks (e.g. Friend & Nutman 2005). Popular jargon de scribes these as terranes, bounded by faults or mylonite zones and characterised by rocks of contrasting origin on either side of their tectonic boundaries (Coney et al. 1980). The Isukasia and Faeringehavn terranes (Figs 1, 2) are the oldest terranes at ≥3.75 Ga, and extend from the outer part of Godthabsfjord in the south-west to the margin of the Inland Ice in the north-east, but they might not have a common geological history (Friend & Nutman 2005). The Tre Brodre terrane is mainly represented by the Ikkatoq gneiss and occurs in close spatial relationship with the Faeringehavn terrane, and also as a pronounced thrust unit along the Qarliit Nunaat thrust between the Faeringehavn and Tasiusarsuaq terranes (Fig. 1; Nutman et al. 1989). The terrane boundaries in the inner fjord region near the Inland Ice margin are less well constrained; the Tre Brodre terrane extends into the region from the south-west, the Kapisilik terrane is defined from the northern and eastern part and borders the Tasiusarsuaq terrane to the south and possibly to the east. The terrane accretion is believed to have taken place in two events. The first terrane accretion is defined from the northern part of the region, and possibly involves the Isukasia, Kapisilik and
Low carbohydrate, high fat diet impairs exercise economy and negates the performance benefit from intensified training in elite race walkers

KEY POINTS
Three weeks of intensified training and mild energy deficit in elite race walkers increases peak aerobic capacity independent of dietary support. Adaptation to a ketogenic low carbohydrate, high fat (LCHF) diet markedly increases rates of whole-body fat oxidation during exercise in race walkers over a range of exercise intensities. The increased rates of fat oxidation result in reduced economy (increased oxygen demand for a given speed) at velocities that translate to real-life race performance in elite race walkers. In contrast to training with diets providing chronic or periodised high carbohydrate availability, adaptation to an LCHF diet impairs performance in elite endurance athletes despite a significant improvement in peak aerobic capacity.


ABSTRACT
We investigated the effects of adaptation to a ketogenic low carbohydrate (CHO), high fat diet (LCHF) during 3 weeks of intensified training on metabolism and performance of world-class endurance athletes. We controlled three isoenergetic diets in elite race walkers: high CHO availability (g kg-1  day-1 : 8.6 CHO, 2.1 protein, 1.2 fat) consumed before, during and after training (HCHO, n = 9); identical macronutrient intake, periodised within or between days to alternate between low and high CHO availability (PCHO, n = 10); LCHF (< 50 g day-1 CHO; 78% energy as fat; 2.1 g kg-1  day-1 protein; LCHF, n = 10). Post-intervention, V̇O2 peak during race walking increased in all groups (P < 0.001, 90% CI: 2.55, 5.20%). LCHF was associated with markedly increased rates of whole-body fat oxidation, attaining peak rates of 1.57 ± 0.32 g min-1 during 2 h of walking at ∼80% V̇O2 peak . However, LCHF also increased the oxygen (O2 ) cost of race walking at velocities relevant to real-life race performance: O2 uptake (expressed as a percentage of new V̇O2 peak ) at a speed approximating 20 km race pace was reduced in HCHO and PCHO (90% CI: -7.047, -2.55 and -5.18, -0.86, respectively), but was maintained at pre-intervention levels in LCHF. HCHO and PCHO groups improved times for 10 km race walk: 6.6% (90% CI: 4.1, 9.1%) and 5.3% (3.4, 7.2%), with no improvement (-1.6% (-8.5, 5.3%)) for the LCHF group. In contrast to training with diets providing chronic or periodised high-CHO availability, and despite a significant improvement in V̇O2 peak , adaptation to the topical LCHF diet negated performance benefits in elite endurance athletes, in part due to reduced exercise economy.
Patient activation with respect to advanced heart failure therapy in patients over age 65 years.

BACKGROUND
Clinical and ethical issues persist in determining candidacy for advanced heart failure (HF) therapies in elderly patients. Selection takes many factors into account, including "activation" (engagement and ability to self-manage).


OBJECTIVE
To investigate effects of age, activation, and depression/anxiety on selection and 6-month survival of participants considered for therapy.


METHODS
Consecutive people referred for advanced HF therapy completed the Patient Activation Measure and Hospital Anxiety and Depression Scale. We analyzed data from participants by age (≥65 vs. <65 years), stratified by approval for therapy.


RESULTS
Among 168 referred, 109 were approved, with no difference in activation between age groups (88% highly activated). Similarly, activation was not associated with age among those not approved. Activation was related to anxiety in older, approved participants, but not to depression.


CONCLUSIONS
Concerns regarding reduced self-management in the elderly may not be valid. Age alone should not disqualify a candidate for advanced HF therapy.
HIV/AIDS and mental health

Mental and neurological disorders have an intertwined relationship with HIV, yet are often overlooked when AIDS interventions are planned and implemented. Cognitive disorders, substance abuse, and disorders of personality can influence behavior in ways that lead to greater risk of HIV infection. Conversely, HIV/AIDS itself can lead to psychological conditions due to circumstances surrounding the disease, and psychiatric conditions resulting from HIV-related neurological changes. Such disorders can adversely influence the progression of the disease, lead to noncompliance with prescribed medical treatment, and increase the likelihood that people living with HIV/AIDS (PLWHA) will act in high-risk ways. Since the World Bank is the largest long-term investor in the prevention and mitigation of HIV/AIDS in developing countries, it has an important role to play in mental health interventions related to the HIV/AIDS pandemic. The main purpose of this document is to increase knowledge of the relationship between HIV/AIDS and mental health and highlight the need for psychosocial support for PLWHA. The document begins with a description of the global AIDS pandemic, addresses psychosocial risks for infection, then discusses the socio-economic impact of HIV/AIDS. This is followed by a description of the neuro-psychiatric and psychological disorders associated with HIV/AIDS and the social and economic implications of failing to address these disorders. Next, current World Bank AIDS initiatives are considered, and opportunities and challenges for including mental health and psychosocial interventions in AIDS programming are explored. The document concludes with recommendations for future initiatives aimed at meeting the mental health and psychosocial needs of PLWHA.
Acupuncture for patients with migraine: a randomized controlled trial.

CONTEXT
Acupuncture is widely used to prevent migraine attacks, but the available evidence of its benefit is scarce.


OBJECTIVE
To investigate the effectiveness of acupuncture compared with sham acupuncture and with no acupuncture in patients with migraine.


DESIGN, SETTING, AND PATIENTS
Three-group, randomized, controlled trial (April 2002-January 2003) involving 302 patients (88% women), mean (SD) age of 43 (11) years, with migraine headaches, based on International Headache Society criteria. Patients were treated at 18 outpatient centers in Germany.


INTERVENTIONS
Acupuncture, sham acupuncture, or waiting list control. Acupuncture and sham acupuncture were administered by specialized physicians and consisted of 12 sessions per patient over 8 weeks. Patients completed headache diaries from 4 weeks before to 12 weeks after randomization and from week 21 to 24 after randomization.


MAIN OUTCOME MEASURES
Difference in headache days of moderate or severe intensity between the 4 weeks before and weeks 9 to 12 after randomization.


RESULTS
Between baseline and weeks 9 to 12, the mean (SD) number of days with headache of moderate or severe intensity decreased by 2.2 (2.7) days from a baseline of 5.2 (2.5) days in the acupuncture group compared with a decrease to 2.2 (2.7) days from a baseline of 5.0 (2.4) days in the sham acupuncture group, and by 0.8 (2.0) days from a baseline if 5.4 (3.0) days in the waiting list group. No difference was detected between the acupuncture and the sham acupuncture groups (0.0 days, 95% confidence interval, -0.7 to 0.7 days; P = .96) while there was a difference between the acupuncture group compared with the waiting list group (1.4 days; 95% confidence interval; 0.8-2.1 days; P<.001). The proportion of responders (reduction in headache days by at least 50%) was 51% in the acupuncture group, 53% in the sham acupuncture group, and 15% in the waiting list group.


CONCLUSION
Acupuncture was no more effective than sham acupuncture in reducing migraine headaches although both interventions were more effective than a waiting list control.
Ofatumumab as single-agent CD20 immunotherapy in fludarabine-refractory chronic lymphocytic leukemia.

PURPOSE
New treatments are needed for patients with fludarabine- and alemtuzumab-refractory (FA-ref) chronic lymphocytic leukemia (CLL) or patients with fludarabine-refractory CLL with bulky (> 5 cm) lymphadenopathy (BF-ref) who are less suitable for alemtuzumab treatment; these groups have poor outcomes with available salvage regimens. Ofatumumab (HuMax-CD20) is a human monoclonal antibody targeting a distinct small-loop epitope on the CD20 molecule. We conducted an international clinical study to evaluate the efficacy and safety of ofatumumab in patients with FA-ref and BF-ref CLL.


PATIENTS AND METHODS
Patients received eight weekly infusions of ofatumumab followed by four monthly infusions during a 24-week period (dose 1 = 300 mg; doses 2 to 12 = 2,000 mg); response by an independent review committee (1996 National Cancer Institute Working Group criteria) was assessed every 4 weeks until week 24 and then every 3 months until month 24.


RESULTS
This planned interim analysis included 138 treated patients with FA-ref (n = 59) and BF-ref (n = 79) CLL. The overall response rates (primary end point) were 58% [corrected] and 47% in the FA-ref and BF-ref groups, respectively. Complete resolution of constitutional symptoms and improved performance status occurred in 57% and 48% of patients, respectively. Median progression-free survival and overall survival times were 5.7 and 13.7 months in the FA-ref group, respectively, and 5.9 and 15.4 months in the BF-ref group, respectively. The most common adverse events during treatment were infusion reactions and infections, which were primarily grade 1 or 2 events. Hematologic events during treatment included anemia and neutropenia.


CONCLUSION
Ofatumumab is an active, well-tolerated treatment providing clear clinical improvements for fludarabine-refractory patients with very poor-prognosis CLL.
A Nation-Wide Multicenter Retrospective Study of the Epidemiological, Pathological and Clinical Characteristics of Breast Cancer In Situ in Chinese Women in 1999 - 2008

BACKGROUND
Compared with invasive breast cancer, breast cancer in situ (BCIS) is seldom life threatening. However, an increasing incidence has been observed in recent years over the world. The purpose of our study is to investigate the epidemiological, clinical and pathological profiles of BCIS in Chinese women from 1999-2008.


METHODS
Four thousand and two hundred-eleven female breast cancer (BC) patients were enrolled in this hospital-based nation-wide and multi-center retrospective study. Patients were randomly selected from seven hospitals in seven representative geographical regions of China between 1999 and 2008. The epidemiological, clinical and pathological data were collected based on the designed case report form (CRF).


RESULTS
There were one hundred and forty-three BCIS cases in four thousand and two hundred-eleven BC patients (3.4%). The mean age at diagnosis was 48.3 years and BCIS peaked in age group 40-49 yrs (39.9%). The most common subtype was ductal carcinoma in situ (DCIS) (88.0%). 53.8% were positive for estrogen receptor (ER). Human epidermal growth factor receptor 2 (HER2) positive status was observed in 23.8% of patients. All patients underwent surgeries and 14.7% of them had breast conservation therapies (BCT) (21/143), but 41.9% accepted chemotherapy (64/143). Much less patients underwent radiotherapy (16.0%, 23/143) and among patients who had BCT, 67% accepted radiotherapy (14/21). Endocrine therapy was taken in 44.1% patients (63/143).


CONCLUSIONS
The younger age of BCIS among Chinese women than Western countries and increasing number of cases pose a great challenge. BCT and endocrine therapy are under great needs.
A Survey on QR Codes : in context of Research and Application

QR code is the type of matrix barcode, which was first designed for the automotive industry by Denso Wave in Japan. The QR Code system has become admired outside the automotive industry due to its fast readability and greater storage capacity compared to standard UPC barcodes. This paper take account of QR codes basics, its real time application in day to day life and research areas associated. With the technology of mobile phones constantly emerging, especially in the area of mobile internet access, QR codes seem to be an adequate tool to quickly and efficiently converse URLs to users. This also allows offline media such as magazines, newspapers, business cards, public transport vehicles, signs, t-shirts and any other medium that can embrace the print of a QR code to be used as carriers for advertisements for online products. QR code being so versatile because of its structural flexibility that it leads to so many diverse field for research such as increasing data capacity, security applications such as different kinds of watermarking and steganography as well. Some experiments have also been done for better recognition of the QR code image that includes scratch removal techniques. Thus, this paper is an attempt to highlight some of possible research areas while considering QR codes. Keywords— QR code, Universal Product Code (UPC), watermarking, security, data capacity, scratch removal.
Attitudes and beliefs of adolescents and parents regarding adolescent suicide.

OBJECTIVE
The goal was to understand the attitudes, beliefs, and perceptions of adolescents and parents of adolescents, from a variety of backgrounds, regarding adolescent suicide.


METHODS
This qualitative study used focus groups to elicit the thoughts of distinct sociodemographic groups. A professional moderator guided the sessions by using a semistructured script. All groups were audiotaped. The transcripts and transcript summaries were analyzed for recurrent themes. The study was performed in community centers and schools in Chicago, Illinois (urban), and the Kansas City, Kansas, area (suburban and rural). A total of 66 adolescents (13-18 years of age) and 30 parents of adolescents participated in 13 focus groups.


RESULTS
Both adolescents and parents recognized adolescent suicide as a major problem, but not for their own communities. All parent and adolescent groups identified many risk factors for suicide. Most adolescents reported drug and alcohol use as risk factors for suicide. However, parents often viewed drug and alcohol use as normal adolescent behavior. Both adolescent and parent groups suggested securing or removing guns if an adolescent was known to be suicidal. All participants requested information about adolescent suicide.


CONCLUSIONS
Adolescents and parents need help understanding that suicide is an underidentified problem in their own communities. Both adolescents and parents are interested in learning more about how to identify and to intervene with a suicidal adolescent. Pediatricians are well positioned to provide this information in the office and in the community.
Metastasis stage, adjuvant treatment, and residual tumor are prognostic factors for medulloblastoma in children: conclusions from the Children's Cancer Group 921 randomized phase III study.

PURPOSE
From 1986 to 1992, "eight-drugs-in-one-day" (8-in-1) chemotherapy both before and after radiation therapy (XRT) (54 Gy tumor/36 Gy neuraxis) was compared with vincristine, lomustine (CCNU), and prednisone (VCP) after XRT in children with untreated, high-stage medulloblastoma (MB).


PATIENTS AND METHODS
Two hundred three eligible patients with an institutional diagnosis of MB were stratified by local invasion and metastatic stage (Chang T/M) and randomized to therapy. Median time at risk from study entry was 7.0 years.


RESULTS
Survival and progression-free survival (PFS) +/- SE at 7 years were 55%+/-5% and 54%+/-5%, respectively. VCP was superior to 8-in-1 chemotherapy, with 5-year PFS rates of 63%+/-5% versus 45%+/-5%, respectively (P = .006). Upon central neuropathology review, 188 patients were confirmed as having MB and were the subjects for analyses of prognostic factors. Children aged 1.5 to younger than 3 years had inferior 5-year estimates of PFS, compared with children 3 years old or older (P = .0014; 32%+/-10% v 58%+/-4%, respectively). For MB patients 3 years of age or older, the prognostic effect of tumor spread (MO v M1 v M2+) on PFS was powerful (P = .0006); 5-year PFS rates were 70%+/-5%, 57%+/-10%, and 40%+/-8%, respectively. PFS distributions at 5 years for patients with M0 tumors with less than 1.5 cm2 of residual tumor, versus > or = 1.5 cm2 of residual tumor by scan, were significantly different (P = .023; 78%+/-6% v 54%+/-11%, respectively).


CONCLUSION
VCP plus XRT is a superior adjuvant combination compared with 8-in-1 chemotherapy plus XRT. For patients with M0 tumors, residual tumor bulk (not extent of resection) is a predictor for PFS. Patients with M0 tumors, > or = 3 years with < or = 1.5 cm2 residual tumor, had a 78%+/-6% 5-year PFS rate. Children younger than 3 years old who received a reduced XRT dosage had the lowest survival rate.