LLukas22/scidocs huggingface dataset:
Composite versus conventional coronary artery bypass grafting strategy for the anterolateral territory: study protocol for a randomized controlled trial

BACKGROUND
In severe coronary artery disease, coronary artery bypass grafting (CABG) surgery is indicated to re-establish an adequate blood supply to the ischemic myocardium. Effectiveness of CABG surgery for symptom relief and mortality decrease should therefore depend on bypass graft patency. As bypass using a left internal mammary artery (LIMA)-to-left anterior descending coronary artery (LAD) anastomosis allows the best results in terms of graft patency, we designed a new surgical technique using a saphenous vein graft as a venous bridge to distribute the LIMA flow to the cardiac anterolateral territory. This novel strategy could extend the patency benefits associated to the LIMA. Other potential benefits of this technique include easier surgical technique, possibility to use saphenous vein grafts as vein patch angioplasty, shorter saphenous vein grafts requirement and reduced or eliminated manipulations of the ascendant aorta (and associated stroke risk).


METHODS/DESIGN
Between July 2012 and 2016, 200 patients undergoing a primary isolated CABG surgery using cardiopulmonary bypass with a LAD bypass graft and at least another target on the anterolateral territory will be randomized (1:1) according to 1) the new composite strategy and 2) the conventional strategy with a LIMA-to-LAD anastomosis and revascularization of the other anterolateral target(s) with a separated aorto-coronary saphenous vein graft. The primary objective of the trial is to assess whether the composite strategy allows non-inferior anterolateral graft patency index (proportion of non-occluded CABGs out of the total number of CABGs) compared to the conventional technique. The primary outcome is the anterolateral graft patency index, evaluated at one year by 256-slice computed tomography angiography. Ten years of clinical follow-up is planned to assess clinical outcomes including death, myocardial infarction and need for revascularization.


DISCUSSION
This non-inferiority trial has the potential to advance the adult cardiac surgery field, given the potential benefits associated with the composite grafting strategy.


TRIAL REGISTRATION
ClinicalTrials.gov: NCT01585285.
Symptom correlates of facial emotion recognition impairment in schizophrenia.

BACKGROUND
The ability to facial emotion recognition (FER), a key component of socioemotional competence, is often impaired in schizophrenic disorders. The purpose of the present study was to examine the relationship between emotion recognition performance and symptoms in a group of patients with schizophrenia spectrum disorders.


SAMPLING AND METHODS
Seventy-nine patients meeting DSM-IV-TR criteria for schizophrenia, schizophreniform disorder and schizoaffective disorder were assessed by the Positive and Negative Syndrome Scale and a FER task. In schizophrenia patients and healthy control subjects, FER performance was compared. In order to avoid a possible confounding role of cognitive impairment, we carried out partial correlations corrected for an index of global cognition.


RESULTS
Patients performed worse than a healthy control group on all negative emotions. Partial correlations showed that cognitive/disorganized symptoms correlated with a worse performance in the FER task, whereas no correlations were found with positive, negative, excitement and depressive symptoms.


CONCLUSIONS
Our findings support that in schizophrenia FER impairment is specific for negative emotions and that there is a relationship between this deficit and cognitive/disorganized symptoms, regardless of the general cognitive level.
Beyond Mechanical Turk : An Analysis of Paid Crowd Work Platforms

Amazon’s Mechanical Turk (AMT) has revolutionized data processing and collection in both research and industry and remains one of the most prominent paid crowd work platforms today (Kittur et al., 2013). Unfortunately, it also remains in beta nine years after its launch with many of the same limitations as when it was launched: lack of worker profi indicating skills or experience, inability to post worker or employer ratings and reviews, minimal infrastructure for eff ely managing workers or collecting analytics, etc. Difficulty accomplishing quality, complex work with AMT continues to drive active research. Fortunately, many other alternative platforms now exist and off a wide range of features and workflow models for accomplishing quality work (crowdsortium.org). Despite this, research on crowd work has continued to focus on AMT near-exclusively. By analogy, if one had only ever programmed in Basic, how might this limit one’s conception of programming? What if the only search engine we knew was AltaVista? Adar (2011) opined that prior research has often been envisioned too narrowly for AMT, “...writing the user’s manual for MTurk ... struggl[ing] against the limits of the platform...”. Such narrow focus risks AMT’s particular vagaries and limitations unduly shape research questions, methodology, and imagination. To assess the extent of AMT’s infl upon research questions and use, we review its impact on prior work, assess what functionality and workflows other platforms off and consider what light other platforms’ diverse capabilities may shed on current research practices and future directions. To this end, we present a qualitative content analysis (Mayring, 2000) of ClickWorker, CloudFactory, CrowdComputing Systems, CrowdFlower, CrowdSource, MobileWorks, and oDesk. To characterize and diff entiate crowd work platforms, we identify several key categories for analysis. Our qualitative content analysis assesses each platform by drawing upon a variety of information sources: Webpages, blogs, news articles, white papers, and research papers. We also shared our analyses with platform representatives and incorporated their feedback. Contributions. Our content analysis of crowd work platforms represents the first such study we know of by researchers for researchers, with categories of analysis chosen based on research relevance. Contributions include our review of how AMT assumptions and limitations have influenced prior research, the detailed criteria we developed for characterizing crowd work platforms, and our analysis. Findings inform
Multilabel Classification with Label Correlations and Missing Labels

Many real-world applications involve multilabel classification, in which the labels can have strong interdependencies and some of them may even be missing. Existing multilabel algorithms are unable to handle both issues simultaneously. In this paper, we propose a probabilistic model that can automatically learn and exploit multilabel correlations. By integrating out the missing information, it also provides a disciplined approach to the handling of missing labels. The inference procedure is simple, and the optimization subproblems are convex. Experiments on a number of real-world data sets with both complete and missing labels demonstrate that the proposed algorithm can consistently outperform stateof-the-art multilabel classification algorithms.
Therapeutic Uses of Withania Somnifera ( Ashwagandha ) with a Note on Withanolides and Its Pharmacological Actions

Withania somnifera is a medicinal plant extends over a large area, from the Atlantic ocean to South East Asia and from the Mediterranean region to South Africa. The medicinal plants are widely used by the traditional medical practitioners for curing various diseases in their day to day practice. In traditional systems of medicine, different parts (leaves, stem, flower, root, seeds, bark and even whole plant) of Withania somnifera (known as Ashwagandha in Hindi), a small herb seen throughout India, have been recommended for the treatment of aphrodisiac, liver tonic, antiinflammatory agent, astringent, and more recently to treat bronchitis, asthma, ulcers, emaciation, insomnia, and senile dementia etc. Clinical trials and animal research support the therapeutic use of ashwaganda for anxiety, cognitive and neurological disorders, inflammation, and Parkinson’s disease. Ashwaganda’s chemopreventive properties make it a potentially useful adjunct for the patients undergoing radiation and chemotherapy. Ashwaganda is also used therapeutically as an adaptogen for patients with nervous exhaustion, insomnia, and debility due to stress, and as an immune stimulant in patients with low white blood cell counts in blood. The major biochemical constituents of ashwaganda root are steroidal alkaloids and steroidal lactones in a class of constituents called withanolides.
3D synthesis of man-made objects based on fine-grained parts

We present a novel approach for 3D shape synthesis from a collection of existing models. The main idea of our approach is to synthesize shapes by recombining fine-grained parts extracted from the existing models based purely on the objects’ geometry. Thus, unlike most previous works, a key advantage of our method is that it does not require a semantic segmentation, nor part correspondences between the shapes of the input set. Our method uses a template shape to guide the synthesis. After extracting a set of fine-grained segments from the input dataset, we compute the similarity among the segments in the collection and segments of the template using shape descriptors. Next, we use the similarity estimates to select, from the set of fine-grained segments, compatible replacements for each part of the template. By sampling different segments for each part of the template, and by using different templates, our method can synthesize many distinct shapes that have a variety of local fine details. Additionally, we maintain the plausibility of the objects by preserving the general structure of the template. We show with several experiments performed on different datasets that our algorithm can be used for synthesizing a wide variety of man-made objects. © 2018 Elsevier Ltd. All rights reserved.
Judgmental aggregation strategies depend on whether the self is involved

We report the results of a novel experiment that addresses two unresolved questions in the judgmental forecasting literature. First, how does combining the estimates of others differ from revising one’s own estimate based on the judgment of another? The experiment found that participants often ignored advice when revising an estimate but averaged estimates when combining. This was true despite receiving identical feedback about the accuracy of past judgments. Second, why do people consistently tend to overweight their own opinions at the expense of profitable advice? We compared two prominent explanations for this, differential access to reasons and egocentric beliefs, and found that neither adequately accounts for the overweighting of the self. Finally, echoing past research, we find that averaging opinions is often advantageous, but that choosing a single judge can perform well in certain predictable situations. c ⃝ 2010 International Institute of Forecasters. Published by Elsevier B.V. All rights reserved.
A phase I/II trial of gefitinib given concurrently with radiotherapy in patients with nonmetastatic prostate cancer.

e16079 Background: We estimated the safety and tolerability of 250 mg gefitinib q.d. given concurrently with three- dimensional conformal radiotherapy (3D-CRT) in patients with non-metastatic prostate cancer (PC).


METHODS
42 patients with T2/T3N0M0 PC were treated in a single centre, non-randomized study (study code ZD1839/IL0118). PSA<20 and good performance status (WHO 0-1) were required. Adjuvant or neo-adjuvant hormonal treatments were not allowed. 250 mg gefitinib q.d. was started one week before and lasted for the duration of radiation therapy. 50.4 Gy (1.8 Gy/day) of 3D-CRT was administered to the tumor, prostate and seminal vesicles, followed by a 22 Gy booster (2 Gy/day) for a 72.4 Gy total dose. EGFR expression, presence of EGFRvIII and activated pEGFR were studied. Levels of serum TNF, IL-1 α and IL-6 were also evaluated.


RESULTS
Maximum tolerated dose was not reached in phase I (12 patients) and 30 additional patients were treated in phase II. Thirty (71.4%) patients completed trial medication and 12 (28.6%) prematurely discontinued because of adverse events. Dose-limiting toxicities were recorded in 16 (38.1%) patients, the most common of which was grade 3-4 transaminase increase (6 patients). After median follow-up of 38 months nobody had died of PC. The estimated PSA-free survival rate at 4 years (Kaplan-Meier) was 97%, hormone-free survival 91% and overall survival 87%. These figures compared favourably with matched, non-randomized patients treated with radiation only. Data on biochemical analyses will be presented.


CONCLUSIONS
The combination of gefitinib and radiation is reasonably well tolerated and has promising activity in non-metastatic PC. A randomized study is being discussed for evaluating the efficacy of the approach. [Table: see text].
Interactive Visualization of Search Intent for Exploratory Information Retrieval

Searching for relevant documents from a vast amount of scientific data is a challenging problem that requires a close interaction between the user, the search interface and the search engine. This extended abstract summarizes recent research on Intent Radar, an interactive search user interface that allows the user to directly interact with her estimated search intent, and in this way direct the search in an intuitive way without the need to type specific queries. In user experiments, Intent Radar improves task performance and quality of retrieved information without compromising the task execution time. This workshop paper presents to the ICML Crowdsourcing and Human Computing workshop audience our work recently published in CIKM 2013 and IUI 2013 as well as a short discussion of ongoing work on the topic. ICML ’14 Workshop: Crowdsourcing and Human Computing, Beijing, China, 2014. Copyright 2014 by the author(s).
Early menopause and severity of rheumatoid arthritis in women older than 45 years

INTRODUCTION
We aimed to investigate whether recognized hormonal predictors of rheumatoid arthritis (RA) also influence the severity of RA.


METHODS
One hundred thirty-four incident RA cases identified by four different local and national registers, who had participated in a community-based health survey between 1991 and 1996, were included. By a retrospective structured review of the medical records, information on the use of disease-modifying antirheumatic drugs (DMARDs), erosions on radiographs, rheumatoid factor (RF) status, and disability measured by using the health assessment questionnaire (HAQ) were collected. The variables were added to the SPSS TwoStep Cluster Analysis to reveal natural groupings of RA severity. Known hormonal predictors analyzed were breastfeeding history, history of oral contraceptive (OC) use, and menopausal age.


RESULTS
The mean age at RA diagnosis was 63.4 years; 72% were RF positive, and 28% had received biological treatment. Three clusters were identified, one with severe RA, one with mild/moderate RF-positive RA, and one with mild/moderate RF-negative RA. A significant difference (P = 0.005) was found in the distribution of clusters between patients with a history of early menopause compared with those with menopause after 45 years, with a higher proportion with mild/moderate RF-negative RA in the early-menopause subset. No major difference in severity of the disease was noted depending on OC use or history of breastfeeding.


CONCLUSIONS
Early menopause was associated with a milder form of RA. Hormonal changes may influence pathways that are distinct from those leading to severe, progressive disease.
A Trust Management Model to Enhance Security of Cloud Computing Environments

With the proliferation of cloud computing, the way of reasonable establishment of trust relationship among entities, as a vital part for forming security mechanism in cloud computing environments, is attracting increasing attention. This article introduces a trust management model based on fuzzy set theory and named TMFC including direct trust measurement and computing, connecting, and trust chain incorporating where the issue of recommended trust similarity has been addressed to prevent the behavior of associated cheat of middle nodes. And this model is geared toward the cloud users who are making their decision on whether to use services of some cloud computing providers by giving them trust evaluation sets about providers and then building reasonable trust relationship between them. Our motivation is trying to propose a new idea and method on trust management in cloud computing and further studies are still required to justify the rationality and practicability of this model.
Autotuning Sparse Matrix-Vector Multiplication for Multicore

Sparse matrix-vector multiplication (SpMV) is an important kernel in scientific and engineering computing. Straightforward parallel implementations of SpMV often perform poorly, and with the increasing variety of architectural features in multicore processors, it is getting more difficult to determine the sparse matrix data structure and corresponding SpMV implementation that optimize performance. In this paper we present pOSKI, an autotuning system for SpMV that automatically searches over a large set of possible data structures and implementations to optimize SpMV performance on multicore platforms. pOSKI explores a design space that depends on both the nonzero pattern of the sparse matrix, typically not known until run-time, and the architecture, which is explored off-line as much as possible, in order to reduce tuning time. We demonstrate significant performance improvements compared to previous serial and parallel implementations, and compare performance to upper bounds based on architectural models. General Terms: Design, Experimentation, Performance Additional
The applications of harmonic functions to robotics

Harmonic functions are solutions to Laplace's Equation. As noted in a previous paper, they can be used to advantage for potentialeld path planning, since they do not exhibit spurious local minima. In this paper, harmonic functions are shown to have a number of other properties (including completeness) which are essential to robotics applications. These properties strongly recommend harmonic functions as a mechanism for robot control.
Organizational Learning and Organizational Capabilities of Firms that Engage in Onshore and Offshore Business Process Outsourcing

Firms are increasingly using onshore and offshore business process outsourcing (BPO) to manage their front and back office functions. While most IS research uses transaction cost economics (TCE) to study the transaction-level characteristics that facilitate outsourcing, to advance theory there is a need to focus on the firm-level characteristics that facilitate onshore and offshore BPO. This paper builds on prior research in organizational learning and organizational capabilities to propose a theoretical framework for adoption of onshore and offshore BPO, and tests the framework using archival data.
Lamivudine-zidovudine combination for prevention of maternal-infant transmission of HIV-1.

CONTEXT
Zidovudine reduces maternal-infant transmission of human immunodeficiency virus 1 (HIV-1) infection by two thirds. Combination antiretroviral therapies are potentially more effective prevention.


OBJECTIVES
To assess the safety of perinatal lamivudine-zidovudine therapy, especially in children, and its effects on viral load, acquisition of drug resistance, and maternal-infant transmission of HIV-1 in a nonbreastfeeding population.


DESIGN AND SETTING
The Agence Nationale de Recherches sur le SIDA (ANRS) 075 Study, an open-label, nonrandomized intervention trial conducted in the context of an ongoing observational cohort study in 48 sites in France.


PATIENTS
A total of 445 HIV-1-infected pregnant women were enrolled as the study cohort from February 1997 to September 1998; controls consisted of 899 pregnant women who had received zidovudine monotherapy in May 1994 to February 1997 as standard care.


INTERVENTION
The study cohort received lamivudine in addition to the standard Pediatric AIDS Clinical Trial Group 076 Study zidovudine prophylaxis regimen. Lamivudine was initiated in women at 32 weeks' gestation through delivery at 150 mg twice per day orally; children received lamivudine, 2 mg/kg twice per day for 6 weeks.


MAIN OUTCOME MEASURES
HIV-1 infection status and tolerance of therapy in children through age 18 months; maternal plasma HIV-1 RNA levels through 6 weeks after delivery.


RESULTS
The transmission rate in the study group was 1.6% (7/437; 95% confidence interval [CI], 0.7%-3.3%). In a multivariable analysis, transmission in the study group was 5-fold lower than in controls. In the study group, maternal plasma HIV-1 RNA level was less than 500 copies/mL at delivery in 74%; the median decrease was 1.24 (range, -1.63 to 3.40) log(10) copies/mL. The M184V lamivudine resistance mutation was detected at 6 weeks after delivery in specimens from 52 of 132 women. The most frequent serious adverse events in children were neutropenia and anemia, requiring blood transfusion in 9 children and premature treatment discontinuation in 19. Two uninfected children died at age 1 year from neurologic complications related to mitochondrial dysfunction.


CONCLUSIONS
Lamivudine-zidovudine may be effective in preventing maternal-infant HIV transmission. However, severe adverse effects and emergence of resistance to lamivudine occurred. Thus, the role of this combination therapy in this setting is as yet unclear, and further research involving a variety of strategies is needed to definitively ascertain its utility for preventing maternal-infant HIV transmission.
Long-term results of wide surgical excision in 106 patients with hidradenitis suppurativa.

BACKGROUND
Hidradenitis suppurativa (acne inversa) is a chronic recurrent disorder characterized by abscessing inflammation, fistulating sinus tracts, and scarring. Predilection sites are the intertriginal regions. The severe course of the disease demands an early and curative treatment.


OBJECTIVE
The aim of this study was to review the effect of radical surgical excision concerning cure rate and potential complications within a large group of patients.


METHODS
We analyzed data for 106 patients suffering from hidradenitis suppurativa treated during the period 1980-1998. The mean duration of the disease was 7 years. In about 90% of the cases, two or more sites were affected. Inguinal (70.8%) and axillary regions (61.3%) were most commonly involved. All patients were treated by radical wide excision using intraoperative marking of sinus tracts with methylviolet solution. The method of reconstruction depended on the size and location of the defect. Median postoperative follow-up time was 36 months.


RESULTS
The overall complication rate was 17.8%. Most of these were minor complications such as suture dehiscence, postoperative bleeding, and hematoma. Wound infection occurred in only 3.7% of patients. The rate of recurrence within the operated fields was 2.5%. There was no relation between the surgical method of reconstruction and the rate of recurrence. Recurrence was related to the severity of the disorder.


CONCLUSION
Our results confirm early radical excision as the treatment of choice for hidradenitis suppurativa. Using intraoperative color-marking of sinus tracts, the recurrence rate is minimal. The method of reconstruction has no influence on recurrence and should be chosen with respect to the size and location of the excised area.