LLukas22/scidocs huggingface dataset:
Association of fitness with vascular intima-media thickness and elasticity in adolescence.

OBJECTIVES
Vascular intima-media thickness (IMT) and elasticity are surrogate markers of atherosclerosis. Data on the effect of cardiorespiratory fitness on these measures of vascular health in adolescence are scarce. The aim was to examine the association of fitness with aortic and carotid artery IMT and elasticity in adolescents.


METHODS
Aortic (n = 449) and carotid (n = 467) IMT and elasticity were measured ultrasonographically in 17-year-old adolescents participating in a prospective, longitudinal atherosclerosis prevention study (Special Turku Coronary Risk Factor Intervention Project). Distensibility and Young's elastic modulus (YEM) were used as measures of arterial elasticity. Cardiorespiratory fitness (maximum oxygen uptake, mL/kg/min) was measured with a maximal cycle ergometer test. Data on fitness were available for 341 of adolescents with aortic and 355 with carotid ultrasound measures.


RESULTS
Fitness was inversely associated with aortic IMT (β[SE] = -0.0029[0.0013]; P = .031) and YEM (β[SE] = -0.012[0.0053]; P = .025) after adjusting for gender, physical activity, high-density lipoprotein/total cholesterol, triglycerides, high-sensitivity C-reactive protein, homeostasis model of assessment-insulin resistance, BMI, systolic blood pressure, and smoking. Risk of having low aortic distensibility (≤10th percentile) decreased with increasing fitness (odds ratio = 0.89, 95% confidence interval 0.82-0.98); P = .014). The increase in aortic IMT and YEM between ages 11 and 17 years was smaller in adolescents who were fit at age 17 compared with adolescents who had the lowest fitness level (P for IMT = .015, P for YEM = .0072). Fitness was not associated with carotid IMT or elasticity. Lifestyle counseling given in the Special Turku Coronary Risk Factor Intervention Project was not associated with fitness.


CONCLUSIONS
Fitness was favorably associated with aortic IMT and elasticity in adolescents. No association of fitness with the respective carotid indices was found. These data suggest that fitness in part enhances vascular health in healthy adolescents.
Parts, Wholes, and Context in Reading: A Triple Dissociation

Research in object recognition has tried to distinguish holistic recognition from recognition by parts. One can also guess an object from its context. Words are objects, and how we recognize them is the core question of reading research. Do fast readers rely most on letter-by-letter decoding (i.e., recognition by parts), whole word shape, or sentence context? We manipulated the text to selectively knock out each source of information while sparing the others. Surprisingly, the effects of the knockouts on reading rate reveal a triple dissociation. Each reading process always contributes the same number of words per minute, regardless of whether the other processes are operating.
Experience with independent radiological review during a topotecan trial in ovarian cancer.

BACKGROUND
The results of phase II clinical trials are usually based on response of tumours to new oncolytic agents as evidenced by radiological imaging techniques. In this trial, all claimed responders were reviewed at a specially convened meeting by the peer group of study investigators and a radiologist, independent of the study institutions.


PATIENTS AND METHODS
One hundred eleven patients with advanced epithelial ovarian cancer who had previously been treated with a platinum based regimen and had subsequently relapsed and who had measurable disease were treated with topotecan at a dose of 1.5 mg/m2/day i.v. on five consecutive days repeated every 21 days to assess efficacy and tolerability. Ninety-three were considered eligible for the study per protocol and lesions were assessed by either computerised tomography (CT) or ultrasound (US). At the meeting, scans from all 24 (25.8%) claimed responders were reviewed, lesions remeasured by the radiologist and a group discussion led to a final response classification.


RESULTS
Ninety-two patients were found to be eligible for the study and 14 (15.2%) were confirmed as responders. Ten were rejected as responders, mainly because the lesion did not decrease in size by < or = 50%, but one patient failed to meet the entry criteria. Remeasurement of CT scans was more objective than US scans. Difficulties were encountered during review of some CT scan sequences because of non-uniform imaging parameters.


CONCLUSIONS
Independent radiological review in conjunction with the peer review group in this trial enabled rigorous and consistent application of response criteria. This decreased the response rate from 25.8% to 15.2%, but this represents a more objective assessment. CT scanning is an objective technique for assessing response rates in phase II studies whereas US is subjective and dose not necessarily allow accurate lesion assessment on subsequent examinations, nor allows independent review at a later date. For these reasons it should not be used in such studies for accurate lesion assessment. Cross-sectional imaging techniques such as CT and magnetic resonance imaging (MRI) do allow accurate lesion assessment and independent review at a later date, but standard protocols need to be instituted, to allow consistency and a comparison to be made with subsequent studies using the same agent and a broad comparison to be made with other agents.
A myo-inositol-1-phosphate synthase gene, IbMIPS1, enhances salt and drought tolerance and stem nematode resistance in transgenic sweet potato.

Myo-inositol-1-phosphate synthase (MIPS) is a key rate limiting enzyme in myo-inositol biosynthesis. The MIPS gene has been shown to improve tolerance to abiotic stresses in several plant species. However, its role in resistance to biotic stresses has not been reported. In this study, we found that expression of the sweet potato IbMIPS1 gene was induced by NaCl, polyethylene glycol (PEG), abscisic acid (ABA) and stem nematodes. Its overexpression significantly enhanced stem nematode resistance as well as salt and drought tolerance in transgenic sweet potato under field conditions. Transcriptome and real-time quantitative PCR analyses showed that overexpression of IbMIPS1 up-regulated the genes involved in inositol biosynthesis, phosphatidylinositol (PI) and ABA signalling pathways, stress responses, photosynthesis and ROS-scavenging system under salt, drought and stem nematode stresses. Inositol, inositol-1,4,5-trisphosphate (IP3 ), phosphatidic acid (PA), Ca(2+) , ABA, K(+) , proline and trehalose content was significantly increased, whereas malonaldehyde (MDA), Na(+) and H2 O2 content was significantly decreased in the transgenic plants under salt and drought stresses. After stem nematode infection, the significant increase of inositol, IP3 , PA, Ca(2+) , ABA, callose and lignin content and significant reduction of MDA content were found, and a rapid increase of H2 O2 levels was observed, peaked at 1 to 2 days and thereafter declined in the transgenic plants. This study indicates that the IbMIPS1 gene has the potential to be used to improve the resistance to biotic and abiotic stresses in plants.
IT Governance : How Top Performers Manage IT Decision Rights for Superior Results

Successful electronic government requires the successful implementation of technology. This book lays out a framework for understanding a system of decision processes that have been shown to be associated with the successful use of technology. Peter Weill and Jeanne Ross are based at the Center for Information Systems Research at MIT’s Sloan School of Management, which has been doing research on the management of information technology since 1974. Understanding how to make decisions about information technology has been a primary focus of the Center for decades. Weill and Ross’ book is based on two primary studies and a number of related projects. The more recent study is a survey of 256 organizations from the Americas, Europe, and Asia Pacific that was led by Peter Weill between 2001 and 2003. This work also included 32 case studies. The second study is a set of 40 case studies developed by Jeanne Ross between 1999 and 2003 that focused on the relationship between information technology (IT) architecture and business strategy. This work identified governance issues associated with IT and organizational change efforts. Three other projects undertaken by Weill, Ross, and others between 1998 and 2001 also contributed to the material described in the book. Most of this work is available through the CISR Web site, http://mitsloan.mit.edu/cisr/rmain.php. Taken together, these studies represent a substantial body of work on which to base the development of a frameBOOK REVIEW
Humanitarian aid logistics: supply chain management in high gear

This paper builds on the idea that private sector logistics can and should be applied to improve the performance of disaster logistics but that before embarking on this the private sector needs to understand the core capabilities of humanitarian logistics. With this in mind, the paper walks us through the complexities of managing supply chains in humanitarian settings. It pinpoints the cross learning potential for both the humanitarian and private sectors in emergency relief operations as well as possibilities of getting involved through corporate social responsibility. It also outlines strategies for better preparedness and the need for supply chains to be agile, adaptable and aligned—a core competency of many humanitarian organizations involved in disaster relief and an area which the private sector could draw on to improve their own competitive edge. Finally, the article states the case for closer collaboration between humanitarians, businesses and academics to achieve better and more effective supply chains to respond to the complexities of today’s logistics be it the private sector or relieving the lives of those blighted by disaster. Journal of the Operational Research Society (2006) 57, 475–489. doi:10.1057/palgrave.jors.2602125 Published online 14 December 2005
Exposure-Response Relationship for Ombitasvir and Paritaprevir/Ritonavir in Hepatitis C Virus Subgenotype 1b-Infected Japanese Patients in the Phase 3 Randomized GIFT-I Study.

INTRODUCTION
The all-oral 2 direct-acting antiviral (DAA) regimen of ombitasvir/paritaprevir/ritonavir 25/150/100 mg once a day has been evaluated in hepatitis C virus subgenotype 1b-infected Japanese adults in the GIFT-I study. The aim of this analysis was to evaluate potential relationships between DAA exposures and laboratory abnormalities/adverse events of peripheral edema in patients in GIFT-I.


METHODS
The GIFT-I study consisted of a randomized, double-blind, placebo-controlled substudy in patients without cirrhosis and an open-label substudy in patients with compensated cirrhosis. Patients received ombitasvir/paritaprevir/ritonavir for 12 weeks. Exposure-response relationships between individual components of the ombitasvir/paritaprevir/ritonavir regimen and clinical parameters of interest were explored using pharmacokinetic and clinical data from patients in the study. Graphical analyses were performed. For events that occurred in at least 10 patients (total bilirubin elevation ≥grade 2 and peripheral edema ≥grade 1), multivariate logistic regression analyses were used to identify significant relationships between predictor variables (drug exposures) and response variables (probability of adverse events or laboratory abnormalities), with consideration for the effect of potential covariates and baseline status of response variables.


RESULTS
Data from 321 noncirrhotic and 42 compensated cirrhotic patients were analyzed. There were 14 events of peripheral edema (10 at grade 1 and 4 at grade 2) in patients who received concomitant administration of calcium channel blockers and ombitasvir/paritaprevir/ritonavir. There was no apparent relationship between the incidences of peripheral edema and exposures of paritaprevir, ombitasvir, or ritonavir. There was a shallow relationship between total bilirubin elevation and exposures of paritaprevir which is an inhibitor of bilirubin transporter organic anion-transporting polypeptide 1B. Based on graphical analyses, exposures of paritaprevir, ombitasvir, or ritonavir were weakly associated with hemoglobin decrease, but not associated with post baseline alanine aminotransferase or aspartate aminotransferase elevations.


CONCLUSIONS
In Japanese patients, there were no associations or only shallow relationships between DAA exposures and peripheral edema or laboratory abnormalities. Consequently, therapeutic drug monitoring is not expected to be beneficial in managing patients on the 2-DAA regimen.


TRIAL REGISTRATION
ClinicalTrials.gov identifier, NCT02023099.


FUNDING
AbbVie Inc.
90% write power-saving SRAM using sense-amplifying memory cell

This paper describes a low-power write scheme which reduces SRAM power by 90% by using seven-transistor sense-amplifying memory cells. By reducing the bitline swing to V/sub DD//6 and amplifying the voltage swing by a sense-amplifier structure in a memory cell, the charging and discharging component of the power of the bit/data lines is reduced. A 64-kb test chip has been fabricated and correct read/write operation has been verified. It is also shown that the scheme can also have the capability of leakage power reduction with small modifications. Achievable leakage power reduction is estimated to be two orders of magnitude from SPICE simulation results.
Does the Fit Between Competitive Strategy and Administrative Mechanisms Lead to Superior Performance

At least two different administrative mechanisms are available for the small business manager to develop and pursue a competitive strategy. One refers to managerial skills needed to implement and f ...
Knowledge of Bovine Tuberculosis, Cattle Husbandry and Dairy Practices amongst Pastoralists and Small-Scale Dairy Farmers in Cameroon.

BACKGROUND
Control of bovine tuberculosis (bTB) and zoonotic tuberculosis (zTB) has relied upon surveillance and slaughter of infected cattle, milk pasteurisation and public health education. In Cameroon, like many other sub-Saharan African countries, there is limited understanding of current cattle husbandry or milk processing practices or livestock keepers awareness of bTB. This paper describes husbandry and milk processing practices within different Cameroonian cattle keeping communities and bTB awareness in comparison to other infectious diseases.


STUDY DESIGN
A population based cross-sectional sample of herdsmen and a questionnaire were used to gather data from pastoralists and dairy farmers in the North West Region and Vina Division of Cameroon.


RESULTS
Pastoralists were predominately male Fulanis who had kept cattle for over a decade. Dairy farmers were non-Fulani and nearly half were female. Pastoralists went on transhumance with their cattle and came into contact with other herds and potential wildlife reservoirs of bTB. Dairy farmers housed their cattle and had little contact with other herds or wildlife. Pastoralists were aware of bTB and other infectious diseases such as foot-and-mouth disease and fasciolosis. These pastoralists were also able to identify clinical signs of these diseases. A similar proportion of dairy farmers were aware of bTB but fewer were aware of foot-and-mouth and fasciolosis. In general, dairy farmers were unable to identify any clinical signs for any of these diseases. Importantly most pastoralists and dairy farmers were unaware that bTB could be transmitted to people by consuming milk.


CONCLUSIONS
Current cattle husbandry practices make the control of bTB in cattle challenging especially in mobile pastoralist herds. Routine test and slaughter control in dairy herds would be tractable but would have profound impact on dairy farmer livelihoods. Prevention of transmission in milk offers the best approach for human risk mitigation in Cameroon but requires strategies that improved risk awareness amongst producers and consumers.
Adolescent Suicidal Risk Assessment in Clinician-Patient Interaction

Youth suicide is a major public health problem. It is the third leading cause of death in the United States for ages 13 through 18. Many adolescents that face suicidal thoughts or make a suicide plan never seek professional care or help. Within this work, we evaluate both verbal and nonverbal responses to a five-item ubiquitous questionnaire to identify and assess suicidal risk of adolescents. We utilize a machine learning approach to identify suicidal from non-suicidal speech as well as characterize adolescents that repeatedly attempted suicide in the past. Our findings investigate both verbal and nonverbal behavior information of the face-to-face clinician-patient interaction. We investigate 60 audio-recorded dyadic clinician-patient interviews of 30 suicidal (13 repeaters and 17 non-repeaters) and 30 non-suicidal adolescents. The interaction between clinician and adolescents is statistically analyzed to reveal differences between suicidal versus non-suicidal adolescents and to investigate suicidal repeaters’ behaviors in comparison to suicidal non-repeaters. By using a hierarchical classifier we were able to show that the verbal responses to the ubiquitous questions sections of the interviews were useful to discriminate suicidal and non-suicidal patients. However, to additionally classify suicidal repeaters and suicidal non-repeaters more information especially nonverbal information is required.
Acupuncture improves sleep in postmenopause in a randomized, double-blind, placebo-controlled study.

BACKGROUND
Insomnia increases in frequency as women approach and pass through menopause. Studies have not shown acupuncture efficacy for insomnia in postmenopausal women.


OBJECTIVES
The aim of this study was to evaluate the effectiveness of acupuncture therapy on sleep parameters, depression symptoms and quality of life in postmenopausal women with insomnia.


METHODS
This study included 18 postmenopausal women aged 50-67 years old. Participants had a body mass index ≤ 30 kg/m(2), presented a diagnosis of insomnia according to the DSM-IV criteria, had experienced at least 1 year of amenorrhea and had a follicle stimulating hormone level ≥ 30 mIU/ml. Participants were not using antidepressants, hypnotics or hormonal therapy. This study was randomized, double-blind and placebo-controlled. The sample was divided into two groups: acupuncture and 'sham' acupuncture. We performed ten sessions of acupuncture and 'sham' acupuncture during a period of 5 weeks. A polysomnography exam (PSG) and questionnaires (WHOQOL-BREF, Beck Depression Inventory and Pittsburgh Sleep Quality Index) were completed by all patients before and after the treatment period.


RESULTS
Anthropometric, polysomnographic, and questionnaire data were similar among the groups at baseline. Comparison of baseline and post-treatment data of the acupuncture group showed that treatment resulted in significantly lower scores on the Pittsburgh Questionnaire and an improvement in psychological WHOQOL. The acupuncture group had a higher percentage of the N3 + 4 stage than the sham group in PSG findings.


CONCLUSION
Acupuncture was effective in improving reported sleep quality and quality of life in postmenopausal women with insomnia.
Automatic identification of heart failure diagnostic criteria, using text analysis of clinical notes from electronic health records

OBJECTIVE
Early detection of Heart Failure (HF) could mitigate the enormous individual and societal burden from this disease. Clinical detection is based, in part, on recognition of the multiple signs and symptoms comprising the Framingham HF diagnostic criteria that are typically documented, but not necessarily synthesized, by primary care physicians well before more specific diagnostic studies are done. We developed a natural language processing (NLP) procedure to identify Framingham HF signs and symptoms among primary care patients, using electronic health record (EHR) clinical notes, as a prelude to pattern analysis and clinical decision support for early detection of HF.


DESIGN
We developed a hybrid NLP pipeline that performs two levels of analysis: (1) At the criteria mention level, a rule-based NLP system is constructed to annotate all affirmative and negative mentions of Framingham criteria. (2) At the encounter level, we construct a system to label encounters according to whether any Framingham criterion is asserted, denied, or unknown.


MEASUREMENTS
Precision, recall, and F-score are used as performance metrics for criteria mention extraction and for encounter labeling.


RESULTS
Our criteria mention extractions achieve a precision of 0.925, a recall of 0.896, and an F-score of 0.910. Encounter labeling achieves an F-score of 0.932.


CONCLUSION
Our system accurately identifies and labels affirmations and denials of Framingham diagnostic criteria in primary care clinical notes and may help in the attempt to improve the early detection of HF. With adaptation and tooling, our development methodology can be repeated in new problem settings.
A 2.45-GHz localized elements rectenna

This paper presents new methodology of rectenna circuit conception. Succeeding sources theory, generally used for power electronics conversion, is presented here and integrated to rectenna circuit design. Circuit simulation based on good filter dimensioning which is sufficient for rectenna design is presented. Localized elements technology is employed here to make the circuits instead of micro strip lines technology usually used to make rectenna circuits. Simulation results are presented and validated by measurement results.
Identification of a threshold value for the DEMATEL method using the maximum mean de-entropy algorithm to find critical services provided by a semiconductor intellectual property mall

0957-4174/$ see front matter 2009 Elsevier Ltd. A doi:10.1016/j.eswa.2009.01.073 * Corresponding author. Tel.: +886 3 3706190. E-mail addresses: samli0707@gmail.com (C.-W. L (G.-H. Tzeng). 1 Distinguished Chair Professor. To deal with complex problems, structuring them through graphical representations and analyzing causal influences can aid in illuminating complex issues, systems, or concepts. The DEMATEL method is a methodology which can confirm interdependence among variables and aid in the development of a chart to reflect interrelationships between variables, and can be used for researching and solving complicated and intertwined problem groups. The end product of the DEMATEL process is a visual representation— the impact-relations map—by which respondents organize their own actions in the world. In order to obtain a suitable impact-relations map, an appropriate threshold value is needed to obtain adequate information for further analysis and decision-making. In the existing literature, the threshold value has been determined through interviews with respondents or judged by the researcher. In most cases, it is hard and time-consuming to aggregate the respondents and make a consistent decision. In addition, in order to avoid subjective judgments, a theoretical method to select the threshold value is necessary. In this paper, we propose a method based on the entropy approach, the maximum mean de-entropy algorithm, to achieve this purpose. Using a real case to find the interrelationships between the services of a Semiconductor Intellectual Property Mall as an example, we will compare the results obtained from the respondents and from our method, and show that the impact-relations maps from these two methods could be the same. 2009 Elsevier Ltd. All rights reserved.