LLukas22/scidocs huggingface dataset:
Gamification in education

Today's learners are digital natives. They grew up with digital technologies. Teachers have to solve important issues related to the adaptation of the learning process towards students who have different learning styles and new requirements for teaching and learning. Gamification is one of the educational approaches and techniques that increase motivation and engagement of learners. The aim of the current work is to study and present the nature and benefits of gamification and to provide some ideas how to implement it in education.
Wide Band Meander Line Antenna for Wireless Communication Systems

Abstract: Printed antennas are becoming one of the most popular designs in personal wireless communications systems. In this paper, the design of a novel tapered meander line antenna is presented. The design analysis and characterization of the antenna is performed using the finite difference time domain technique and experimental verifications are performed to ensure the effectiveness of the numerical model. The new design features an operating frequency of 2.55 GHz with a 230 MHz bandwidth, which supports future generations of mobile communication systems.
Performance effects of using the Balanced Scorecard : a note on the Dutch experience

This article aims to contribute to understanding how to use the Balanced Scorecard (BSC) effectively. The BSC lends itself to various interpretations. This article explores how the way in which the BSC is used affects performance. Empirical evidence from Dutch firms suggests BSC use will not automatically improve company performance, but that the manner of its use matters: BSC use that complements corporate strategy positively influences company performance, while BSC use that is not related to the strategy may decrease it. We discuss the findings and offer managers guidance for optimal use of the BSC. Q 2004 Elsevier Ltd. All rights reserved.
DESIGNING AN M-LEARNING APPLICATION FOR A UBIQUITOUS LEARNING ENVIRONMENT IN THE ANDROID BASED MOBILE DEVICES USING WEB

Educational Technology is constantly evolving and growing, and this progression will continually offer new and interesting advances in our learning environment. Traditional E-Learning systems developed for laptop and desktop computers were based on stand-alone software application or through websites and lack the ability to provide a comprehensive ubiquitous learning environment. A ubiquitous learning environment based on early days mobile phones lack the processing power of notebooks or desktop computers, low data transfer speeds and capacity. However, the ability to provide a comprehensive ubiquitous learning environment on the 3G (3 Generation) mobile device will offer powerful collaborative and interactive learning opportunities. Thus the main objective of the research work is to develop an interactive mobile learning application based on Web Services in Android base mobile devices to facilitate the ubiquitous learning. This paper deals with the prototype development of an MLearning application for mobile phones running with Android platform using Web services.
StructVAE: Tree-structured Latent Variable Models for Semi-supervised Semantic Parsing

Semantic parsing is the task of transducing natural language (NL) utterances into formal meaning representations (MRs), commonly represented as tree structures. Annotating NL utterances with their corresponding MRs is expensive and timeconsuming, and thus the limited availability of labeled data often becomes the bottleneck of data-driven, supervised models. We introduce STRUCTVAE, a variational auto-encoding model for semisupervised semantic parsing, which learns both from limited amounts of parallel data, and readily-available unlabeled NL utterances. STRUCTVAE models latent MRs not observed in the unlabeled data as treestructured latent variables. Experiments on semantic parsing on the ATIS domain and Python code generation show that with extra unlabeled data, STRUCTVAE outperforms strong supervised models.1
Spawning and larval rearing technique for tropical clown fish Amphiprion sebae under captive condition

Research on breeding and larval rearing of marine ornamental fishes are in its ~fancy . For the first time in India, successful breedi!19 and larval rearing of Tropical clown fish Amphiprion sebae was accomplished at Regional Centre of Central Marine Fisheries Research Institute, Mandapam Camp. Adult pairs of clown fishes along with sea anemones collected from the in-shore waters of Gulf of Mannar were maintained in one tonne glass aquarium fitted with bio-filters. The fishes were fed with polychaete worms, clam and fish meat. After three months of maintenance natural spawning took place and the fish deposited its eggs on an asbestos substratum placed in the tank. The salinity and temperature of the water media was in the range of 28-32' C and 33-35 ppt respectively. In each spawning the females lay about 300 to 600 eggs, and the incubation period was 6-7 days. Brood stock maintenance, spawning behaviour, and egg development were described. Hatching was effected in a 250 I fibreglass tank containing Chiarella conditioned seawater along with rotiter Brachianus plicatilis. Hatch· ing was successful up to 70% and the newly hatched larvae measured 4-5 mm. Se· quential description of the larval development and the feeding reg ime are detailed. The larvae metamorphosed into adults on the 15th day, and were transferred to 1 ton fibreglass tank containing sea anemones, and the juveniles got accommodated in the anemone within a day. Mortality of clown fish larvae at different developmental stages was Observed especially on the 2nd and 7th day. The reason attributed to the mortality was non·availability of right sized feed and their nutritional insufficiency in terms of essential fatty acids. Two types of combination of live feed Le. rotifer and artemia; rotiter and copepods were tried. Higher survival and growth of larvae was observed in the combination of rotifer and cope pod, which signifies the suitability of copepods to artemia.
Computing and choice of language

Pikes Peak Community College is an average-sized college about 70 miles south of Denver. Its students come from wide ethnic backgrounds including Hispanics and Native Americans. Students are generally prepared to enter college life, although many need some form of academic remediation.
A Randomized Controlled Trial Comparing the Effects of Sitagliptin and Glimepiride on Endothelial Function and Metabolic Parameters: Sapporo Athero-Incretin Study 1 (SAIS1)

OBJECTIVES
The DPP-4 inhibitors are incretin-related drugs that improve hyperglycemia in a glucose-dependent manner and have been reported to exert favorable effects on atherosclerosis. However, it has not been fully elucidated whether DPP-4 inhibitors are able to improve endothelial function in patients with type 2 diabetes. Therefore, we investigated the efficacy of sitagliptin, a DPP-4 inhibitor, on endothelial function and glycemic metabolism compared with that of the sulfonylurea glimepiride.


MATERIALS AND METHODS
In this multicenter, prospective, randomized parallel-group comparison study, 103 outpatients with type 2 diabetes (aged 59.9 ± 9.9 years with HbA1c levels of 7.5 ± 0.4%) with dietary cure only and/or current metformin treatment were enrolled and randomly assigned to receive sitagliptin or glimepiride therapy once daily for 26 weeks. Flow-mediated dilation (FMD), a comprehensive panel of hemodynamic parameters (Task Force® Monitor), and serum metabolic markers were assessed before and after the treatment.


RESULTS
During the study period, no statistically significant change in %FMD was seen in both groups (sitagliptin, 5.6 to 5.6%; glimepiride, 5.6 to 6.0%). Secretory units of islets in transplantation, TNF-α, adiponectin and biological antioxidant potential significantly improved in the sitagliptin group, and superoxide dismutase also tended to improve in the sitagliptin group, while improvements in HbA1c levels were similar between groups. Cardiac index, blood pressure and most other metabolic parameters were not different.


CONCLUSIONS
Regardless of glycemic improvement, early sitagliptin therapy did not affect endothelial function but may provide favorable effects on beta-cell function and on inflammatory and oxidative stress in patients with type 2 diabetes without advanced atherosclerosis.


TRIAL REGISTRATION
UMIN Clinical Trials Registry System UMIN 000004955.
Acropora muricata mortality associated with extensive growth of Caulerpa racemosa in Magoodhoo Island, Republic of Maldives

Caulerpa racemosa, a common and opportunistic species widely distributed in tropical and warm-temperate regions, is known to form monospecific stands outside its native range (Verlaque et al. 2003). In October 2011, we observed an alteration in benthic community due to a widespread overgrowth of C. racemosa around the inhabited island of Magoodhoo (3 04¢N; 72 57¢E, Republic of Maldives). The algal mats formed a continuous dense meadow (Fig. 1a) that occupied an area of 95 · 120 m (~11,000 m) previously dominated by the branching coral Acropora muricata. Partial mortality and total mortality (Fig. 1b, c) were recorded on 45 and 30% of A. muricata colonies, respectively. The total area of influence of C. racemosa was, however, much larger (~25,000 m) including smaller coral patches near to the meadow, where mortality in contact with the algae was also observed on colonies of Isopora palifera, Lobophyllia corymbosa, Pavona varians, Pocillopora damicornis, and Porites solida. Although species of the genus Caulerpa are not usually abundant on oligotrophic coral reefs, nutrient enrichment from natural and/or anthropogenic sources is known to promote green algal blooms (Lapointe and Bedford 2009). Considering the current state of regression of many reefs in the Maldives (Lasagna et al. 2010), we report an unusual phenomenon that could possibly become more common.
Security challenges in automotive hardware/software architecture design

This paper is an introduction to security challenges for the design of automotive hardware/software architectures. State-of-the-art automotive architectures are highly heterogeneous and complex systems that rely on distributed functions based on electronics and software. As cars are getting more connected with their environment, the vulnerability to attacks is rapidly growing. Examples for such wireless communication are keyless entry systems, WiFi, or Bluetooth. Despite this increasing vulnerability, the design of automotive architectures is still mainly driven by safety and cost issues rather than security. In this paper, we present potential threats and vulnerabilities, and outline upcoming security challenges in automotive architectures. In particular, we discuss the challenges arising in electric vehicles, like the vulnerability to attacks involving tampering with the battery safety. Finally, we discuss future automotive architectures based on Ethernet/IP and how formal verification methods might be used to increase their security.
Soft Shadows by Ray Tracing Multilayer Transparent Shadow Maps

We present a method for high quality soft shadows for area lights in cinematic lighting. The method is an extension of traditional shadow maps, so it has the advantage of image based shadow methods; the algorithm’s complexity is independent of geometric complexity. We introduce multilayer transparent shadow maps, which can be used to produce high quality soft shadows for scenes with extremely complex geometry, fur, and volume objects. Instead of the traditional sampling and filtering of shadow maps, we compute the shadow factor by ray tracing the multilayer transparent shadow map. The result is soft shadows of quality similar to that achieved by stochastic ray tracing, but at a much lower cost.
Screening of commercial enzymes for the enantioselective hydrolysis of R,S-naproxen ester

This study focused on the identification of suitable lipase or esterase activity for enantiomeric resolution of ( R,S)-naproxen. For an economically viable reaction the enantiomeric ratio ( E) should preferably be >100, while maximising the conversion will reduce the mass of material that requires racemisation and recycling. Hence the aim was to find an enzyme that yields ( S)-naproxen with an enantiomeric excess of more than 98%, a substrate conversion in excess of 40% of the racemate, and an E of >100. (R,S)-Naproxen ethyl ester (NEE) (50 mg) was used as substrate for enzyme hydrolysis reactions at 37 ◦C for 4 h. Biocatalyst screening was performed in buffered aqueous solvent on a 1 ml scale. The reactions were stopped with 2 ml MeCN, filtered through cotton wool and analysed by HPLC to determine the percentage m/m and R/Sratio. Eight commercially available enzymes were selected for optimisation of enantioselectivity through statistically designed experiments where the reaction conditions were varied. ChiroCLEC-CR from Altus and ESL001-01 from Diversa provided acceptable enantiomeric excess, but only ChiroCLEC-CR met the specification set for the enantiomeric ratio ( E). © 2002 Elsevier Science Inc. All rights reserved.
Early morbidity and mortality in childhood acute lymphoblastic leukemia with very high white blood cell count

Outcome of ETV6/RUNX1-positive childhood acute lymphoblastic leukaemia in the NOPHO-ALL-1992 protocol: frequent late relapses but good overall survival. Br J Haematol 2008; 140: 665–672. 11 Rubnitz JE, Wichlan D, Devidas M, Shuster J, Linda SB, Kurtzberg J et al. Prospective analysis of TEL gene rearrangements in childhood acute lymphoblastic leukemia: a Children’s Oncology Group study. J Clin Oncol 2008; 26: 2186–2191. 12 Bhojwani D, Pei D, Sandlund JT, Jeha S, Ribeiro RC, Rubnitz JE et al. ETV6-RUNX1positive childhood acute lymphoblastic leukemia: improved outcome with contemporary therapy. Leukemia 2012; 26: 265–270. 13 Loh ML, Goldwasser MA, Silverman LB, Poon WM, Vattikuti S, Cardoso A et al. Prospective analysis of TEL/AML1-positive patients treated on Dana-Farber Cancer Institute Consortium Protocol 95-01. Blood 2006; 107: 4508–4513. 14 Waanders E, van der Velden VH, van der Schoot CE, van Leeuwen FN, van Reijmersdal SV, de Haas V et al. Integrated use of minimal residual disease classification and IKZF1 alteration status accurately predicts 79% of relapses in pediatric acute lymphoblastic leukemia. Leukemia 2011; 25: 254–258. 15 Borowitz MJ, Devidas M, Hunger SP, Bowman WP, Carroll AJ, Carroll WL et al. Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia and its relationship to other prognostic factors: a Children’s Oncology Group study. Blood 2008; 111: 5477–5485.
Radioimmunoguided surgery for colorectal cancer

Background: Operations for patients with colorectal cancer are based on traditions established by historical experience. Radioimmunoguided surgery (RIGS) provides new information that challenges these traditions. Methods: Thirty-two patients with primary colorectal cancer underwent RIGS after being injected with anti-TAG-72 murine monoclonal antibody CC49 labeled with iodine-125. Sixteen of the patients had all gross tumor and RIGS-positive tissue removed (RIGS-negative group), and 16 had only traditional extirpation of the tumor because RIGS-positive tissue was too diffuse (RIGS-positive group). Results: In the 16 patients having all RIGS-positive tissue removed, five had traditional regional en bloc resections and 11 had additional extraregional tissues resected. Identification of extraregional disease added two liver resections and 25 lymphadenectomies: 10 of the gastrohepatic ligament, five celiac axis, six retroperitoneal, and four iliac. With a median follow-up of 37 months, survival in the RIGS-negative group is 100%. In 14 of 16 patients (87.5%) there is no evidence of disease. In the RIGS-positive group, follow-up shows 14 of 16 patients are dead and two are alive with disease (p<0.0001). Conclusion: These results suggest that RIGS identifies patterns of disease dissemination different from those identified by traditional staging techniques. Removal of additional RIGS-positive tissues in nontraditional areas may improve survival.
Hepatitis C virus treatment-related anemia is associated with higher sustained virologic response rate.

BACKGROUND & AIMS
Hepatitis C virus (HCV) treatment is frequently complicated by anemia from ribavirin (RBV)-related hemolysis and peginterferon-alfa (PEG-IFN)-related bone marrow suppression. We investigated the relationships among treatment outcomes, anemia, and their management with RBV dose reduction and/or erythropoiesis-stimulating agents (ESAs).


METHODS
We analyzed data from a trial conducted at 118 United States academic and community centers in treatment-naïve patients with HCV genotype 1. Patients were treated for as many as 48 weeks with 1 of 3 PEG-IFN/RBV regimens. ESAs were permitted for anemic patients (hemoglobin [Hb] <10 g/dL) after RBV dose reduction. Sustained virologic responses (SVR) were assessed based on decreases in Hb, anemia, and ESA use.


RESULTS
While patients received treatment, 3023 had their Hb levels measured at least once. An SVR was associated with the magnitude of Hb decrease: >3 g/dL, 43.7%; ≤3 g/dL, 29.9% (P < .001). Anemia occurred in 865 patients (28.6%); 449 of these (51.9%) used ESAs. In patients with early-onset anemia (≤ 8 weeks of treatment), ESAs were associated with higher SVR rate (45.0% vs 25.9%; P < .001) and reduced discontinuation of treatment because of adverse events (12.6% vs 30.1%, P < .001). ESAs did not affect SVR or discontinuation rates among patients with late-stage anemia.


CONCLUSIONS
Among HCV genotype 1-infected patients treated with PEG-IFN/RBV, anemia was associated with higher rates of SVR. The effect of ESAs varied by time to anemia; patients with early-onset anemia had higher rates of SVR with ESA use, whereas no effect was observed in those with late-onset anemia. Prospective trials are needed to assess the role of ESAs in HCV treatment.
Grounded theory and leadership research: a critical realist perspective

Available online 2 February 2011 The methodology of grounded theory has great potential to contribute to our understanding of leadership within particular substantive contexts. However, our notions of good science might constrain these contributions. We argue that for grounded theorists a tensionmight exist between a desire to create a contextualised theory of leadership and a desire for scientifically justified issues of validity and generalizable theory. We also explore how the outcome of grounded theory research can create a dissonance between theories that resonate with the reality they are designed to explore, and the theories that resonate with a particular yet dominant ‘scientific’ approach in the field of leadership studies – the philosophy of science commonly known as positivism. We examine the opportunities provided by an alternative philosophy of science, that of critical realism. We explore how conducting grounded theory research informed by critical realism might strengthen researchers’ confidence to place emphasis on an understanding and explanation of contextualised leadership as a scientific goal, rather than the scientific goal of generalization through empirical replication. Two published accounts of grounded theory are critiqued candidly to help emphasise our arguments. We conclude by suggesting how critical realism can help shape and enhance grounded theory research into the phenomenon of leadership. Crown Copyright © 2010 Published by Elsevier Inc. All rights reserved.
Persistent current HTS magnet cooled by cryocooler (1)-project overview

This paper describes a project overview for a persistent current HTS magnet, which has been in development for Maglev trains since 1999. The HTS magnet operates with a very small current decay rate of 0.44%/day and can be cooled by a cryocooler below 20 K. The HTS coil consists of 12 single-pancake coils, which were wound with 4 parallel Ag-sheathed Bi2223 tapes. In order to minimize the magnetic field decay rate during persistent current operation, we have made efforts not to decrease the high Tc superconductor characteristics during the winding of the single-pancake coils. The HTS coil is connected with a persistent current switch made of a YBCO thin film, and cooled by a G-M (Gifford-MacMahon) type two-stage pulse tube cryocooler. Detachable current leads were used to reduce heat leakage to the 1st stage of the cryocooler.
Dose-dependent effects of NY-ESO-1 protein vaccine complexed with cholesteryl pullulan (CHP-NY-ESO-1) on immune responses and survival benefits of esophageal cancer patients

Cholesteryl pullulan (CHP) is a novel antigen delivery system for cancer vaccines. This study evaluated the safety, immune responses and clinical outcomes of patients who received the CHP-NY-ESO-1 complex vaccine, Drug code: IMF-001. Patients with advanced/metastatic esophageal cancer were enrolled and subcutaneously vaccinated with either 100 μg or 200 μg of NY-ESO-1 protein complexed with CHP. The primary endpoints were safety and humoral immune responses, and the secondary endpoint was clinical efficacy. A total of 25 patients were enrolled. Thirteen and twelve patients were repeatedly vaccinated with 100 μg or 200 μg of CHP-NY-ESO-1 with a median of 8 or 9.5 doses, respectively. No serious adverse events related to the vaccine were observed. Three out of 13 patients in the 100-μg cohort and 7 out of 12 patients in the 200-μg cohort were positive for anti-NY-ESO-1 antibodies at baseline. In the 100-μg cohort, an antibody response was observed in 5 out of 10 pre-antibody-negatives patients, and the antibody levels were augmented in 2 pre-antibody-positive patients after vaccination. In the 200-μg cohort, all 5 pre-antibody-negative patients became seropositive, and the antibody level was amplified in all 7 pre-antibody-positive patients. No tumor shrinkage was observed. The patients who received 200 μg of CHP-NY-ESO-1 survived longer than patients receiving 100 μg of CHP-NY-ESO-1, even those who exhibited unresponsiveness to previous therapies or had higher tumor burdens. The safety and immunogenicity of CHP-NY-ESO-1 vaccine were confirmed. The 200 μg dose more efficiently induced immune responses and suggested better survival benefits. (Clinical trial registration number NCT01003808).