LLukas22/scidocs huggingface dataset:
Association between anti-tumour necrosis factor treatment response and genetic variants within the TLR and NF{kappa}B signalling pathways.

OBJECTIVE
To determine whether genetic variation within genes integral to the Toll-like receptor (TLR) and NFkappaB signalling systems, two cardinal regulators of inflammatory and immune responses, contributes towards the observed variation in response to tumour necrosis factor (TNF) blocking agents in patients with rheumatoid arthritis (RA).


METHODS
Pairwise-tagging single nucleotide polymorphisms (SNPs) spanning 24 candidate genes were selected and genotyped in a large UK cohort of patients receiving anti-TNF therapy for RA. Multivariate regression analyses were performed to test association between individual genotypes, under an additive model, and treatment response at 6 months' follow-up assessed using both the absolute change in 28-joint count Disease Activity Score (DAS28) and the European League Against Rheumatism (EULAR) response criteria. Analyses were performed across subgroups comprising etanercept-, infliximab- and infliximab/adalimumab-treated patients as well as the combined anti-TNF-treated cohort. p Values <0.05 were considered statistically significant.


RESULTS
A total of 187 SNPs were successfully genotyped and analysed in 909 patients. Eight SNPs spanning six genes demonstrated nominal evidence of association with response (DAS28) across the anti-TNF-treated subgroups, six of which were restricted to etanercept-treated patients. Twelve SNPs spanning nine genes demonstrated nominal evidence of association with treatment response (DAS28 and/or EULAR) across the combined anti-TNF cohort. These included SNPs mapping to MyD88 (rs7744) and CHUK (rs11591741), which were associated under each model applied (etanercept-treated and combined anti-TNF cohort analysis (DAS28 and EULAR)).


CONCLUSIONS
Several SNPs mapping to the TLR and NFkappaB signalling systems demonstrated association with anti-TNF response as a whole and, in particular, with response to etanercept. Validation of these findings in an independent cohort is now warranted.
Can I relate? A review and guide for nurse managers in leading generations.

AIMS
The purpose of this review is to help the nurse leader develop an understanding of the five generations currently in the health care workforce by providing defining characteristics, general behaviours, and strategies for the nurse manager to employ for each generational cohort.


BACKGROUND
Generations are groups of people born during the same 15-20 year time period who share similar experiences before adulthood, which shape long-term behaviours. Key descriptors and characteristics are provided.


EVALUATION
The current generational cohorts in the health care workforce are Traditionalists (born between 1922 and 1945), baby boomers (born between 1946 and 1964), Generation X (born between 1965 and 1979), millennials (born between 1980 and 1995), and Generation Z (born after 1995).


KEY ISSUES
Health care teams often comprise members of three or more generations. Intergenerational differences in team members can result in challenges; however, different perspectives provided by multiple generations can be used advantageously to strengthen the team's efficiency and outcomes.


CONCLUSIONS
There are strengths in each generation. Key differences can be harnessed to build stronger teams through comprehensive communication strategies, customized reward systems, and workplace flexibility. Examples are provided for each area.


IMPLICATIONS
Managers can use intergenerational differences to create a rich environment that bridges generational differences and fosters workforce cohesion.
Effect of adding postoperative noninvasive ventilation to usual care to prevent pulmonary complications in patients undergoing coronary artery bypass grafting: a randomized controlled trial.

OBJECTIVE
We compared the efficacy of noninvasive ventilation with bilevel positive airway pressure added to usual care versus usual care alone in patients undergoing coronary artery bypass grafting.


METHODS
We performed a 2-group, parallel, randomized controlled trial. The primary outcome was time until fit for discharge. Secondary outcomes were partial pressure of carbon dioxide, forced expiratory volume in 1 second, atelectasis, adverse events, duration of intensive care stay, and actual postoperative stay.


RESULTS
A total of 129 patients were randomly allocated to bilevel positive airway pressure (66) or usual care (63). Three patients allocated to bilevel positive airway pressure withdrew. The median duration of bilevel positive airway pressure was 16 hours (interquartile range, 11-19). The median duration of hospital stay until fit for discharge was 5 days for the bilevel positive airway pressure group (interquartile range, 4-6) and 6 days for the usual care group (interquartile range, 5-7; hazard ratio, 1.68; 95% confidence interval, 1.08-2.31; P = .019). There was no significant difference in duration of intensive care, actual postoperative stay, and mean percentage of predicted forced expiratory volume in 1 second on day 3. Mean partial pressure of carbon dioxide was significantly reduced 1 hour after bilevel positive airway pressure application, but there was no overall difference between the groups up to 24 hours. Basal atelectasis occurred in 15 patients (24%) in the usual care group and 2 patients (3%) in the bilevel positive airway pressure group. Overall, 30% of patients in the bilevel positive airway pressure group experienced an adverse event compared with 59% in the usual care group.


CONCLUSIONS
Among patients undergoing elective coronary artery bypass grafting, the use of bilevel positive airway pressure at extubation reduced the recovery time. Supported by trained staff, more than 75% of all patients allocated to bilevel positive airway pressure tolerated it for more than 10 hours.
Lactic acid production by Saccharomyces cerevisiae expressing a Rhizopus oryzae lactate dehydrogenase gene

This work demonstrates the first example of a fungal lactate dehydrogenase (LDH) expressed in yeast. A L(+)-LDH gene, ldhA, from the filamentous fungus Rhizopus oryzae was modified to be expressed under control of the Saccharomyces cerevisiae adh1 promoter and terminator and then placed in a 2µ-containing yeast-replicating plasmid. The resulting construct, pLdhA68X, was transformed and tested by fermentation analyses in haploid and diploid yeast containing similar genetic backgrounds. Both recombinant strains utilized 92 g glucose/l in approximately 30 h. The diploid isolate accumulated approximately 40% more lactic acid with a final concentration of 38 g lactic acid/l and a yield of 0.44 g lactic acid/g glucose. The optimal pH for lactic acid production by the diploid strain was pH 5. LDH activity in this strain remained relatively constant at 1.5 units/mg protein throughout the fermentation. The majority of carbon was still diverted to the ethanol fermentation pathway, as indicated by ethanol yields between 0.25–0.33 g/g glucose. S. cerevisiae mutants impaired in ethanol production were transformed with pLdhA68X in an attempt to increase the lactic acid yield by minimizing the conversion of pyruvate to ethanol. Mutants with diminished pyruvate decarboxylase activity and mutants with disrupted alcohol dehydrogenase activity did result in transformants with diminished ethanol production. However, the efficiency of lactic acid production also decreased.
Automatic Annotation Suggestions and Custom Annotation Layers in WebAnno

In this paper, we present a flexible approach to the efficient and exhaustive manual annotation of text documents. For this purpose, we extend WebAnno (Yimam et al., 2013) an open-source web-based annotation tool.1 While it was previously limited to specific annotation layers, our extension allows adding and configuring an arbitrary number of layers through a web-based UI. These layers can be annotated separately or simultaneously, and support most types of linguistic annotations such as spans, semantic classes, dependency relations, lexical chains, and morphology. Further, we tightly integrate a generic machine learning component for automatic annotation suggestions of span annotations. In two case studies, we show that automatic annotation suggestions, combined with our split-pane UI concept, significantly reduces annotation time.
Effects of interfacial pressure on tracking failure between XLPE and silicon rubber

XLPE power cables are increasingly used in power distribution system for their excellent mechanical and electrical performance. However, interface between XLPE and silicon rubber in cable joint remains one of the weakest part of the cable system, because aging and relaxation of silicon rubber may reduce the interfacial pressure and then cause interfacial discharge and tracking failure. Therefore, this paper investigates the effects of interfacial pressure on interface discharge and tracking failure at the interface. Test samples were made by pressing a piece of XLPE and silicon rubber together under different interfacial pressures. AC voltage was applied on a pair of needle-plate electrodes at the interface with the insulation distance of 10 mm. Both the initial discharge voltage and the time to tracking failure were recorded with variation of the interfacial pressure and the applied voltage. Meanwhile, the discharge light and the carbonized configuration were also captured by using a high-speed camera. In order to quantify the light and the carbonization, the methods of image processing and fractal dimension (FD) were employed to establish the relationship between the quantitative characteristics of tracking process and the interfacial pressures. The results show that both the initial discharge voltage and the time to tracking failure increase with the increase of interfacial pressure. With increasing the interfacial pressure, the FDs of discharge light and carbonization path show the decreasing tendency, which indicates that the higher interfacial pressure can effectively delay the interfacial discharges and the tracking failure.
Barium titanate nanoparticles and hypergravity stimulation improve differentiation of mesenchymal stem cells into osteoblasts

BACKGROUND
Enhancement of the osteogenic potential of mesenchymal stem cells (MSCs) is highly desirable in the field of bone regeneration. This paper proposes a new approach for the improvement of osteogenesis combining hypergravity with osteoinductive nanoparticles (NPs).


MATERIALS AND METHODS
In this study, we aimed to investigate the combined effects of hypergravity and barium titanate NPs (BTNPs) on the osteogenic differentiation of rat MSCs, and the hypergravity effects on NP internalization. To obtain the hypergravity condition, we used a large-diameter centrifuge in the presence of a BTNP-doped culture medium. We analyzed cell morphology and NP internalization with immunofluorescent staining and coherent anti-Stokes Raman scattering, respectively. Moreover, cell differentiation was evaluated both at the gene level with quantitative real-time reverse-transcription polymerase chain reaction and at the protein level with Western blotting.


RESULTS
Following a 20 g treatment, we found alterations in cytoskeleton conformation, cellular shape and morphology, as well as a significant increment of expression of osteoblastic markers both at the gene and protein levels, jointly pointing to a substantial increment of NP uptake. Taken together, our findings suggest a synergistic effect of hypergravity and BTNPs in the enhancement of the osteogenic differentiation of MSCs.


CONCLUSION
The obtained results could become useful in the design of new approaches in bone-tissue engineering, as well as for in vitro drug-delivery strategies where an increment of nanocarrier internalization could result in a higher drug uptake by cell and/or tissue constructs.
Systemic tobramycin concentrations during selective decontamination of the digestive tract in intensive care unit patients on continuous venovenous hemofiltration

To study whether selective decontamination of the digestive tract (SDD) results in detectable serum tobramycin concentrations in intensive care unit (ICU) patients with acute renal failure treated with continuous venovenous hemofiltration (CVVH). Prospective, observational, single-center study in a mixed medical–surgical ICU. Adult ICU patients receiving SDD for at least 3 days and being treated with CVVH because of acute renal failure. Tobramycin serum concentrations were measured at the 3rd day after start of CVVH and every 3 days thereafter. Detectable serum concentrations of tobramycin were found in 12 (63%) of 19 patients and in 15 (58%) of the 26 samples. With a toxic tobramycin concentration defined as more than 2.0 mg/l, we found one patient with a toxic concentration of 3.0 mg/l. In three other patients tobramycin concentrations of ≥ 1.0 mg/l were found. In patients with acute renal failure treated with CVVH, administration of SDD with tobramycin can lead to detectable and potentially toxic serum tobramycin concentrations.
Standard-Based Middleware Platform for Medical Sensor Networks and u-Health

Advances in information and communication technologies, ICT, are bringing new opportunities in the field of middleware systems oriented to ubiquitous environments and wearable devices used for patient telemonitoring. At a time of such challenges, this paper arises from the need to identify robust technical telemonitoring solutions that are both open and interoperable in home or mobile scenarios. These middleware systems demand standardized solutions to be cost effective and to take advantage of standardized operation and interoperability. Thus, a fundamental challenge is to design a plug-&-play platform that, either as individual elements or as components, can be incorporated in a simple way into different telecare systems, perhaps configuring a personal user network. Moreover, there is an increasing market pressure from companies not traditionally involved in medical markets, asking for a standard for personal health devices (PHD), which foresee a vast demand for telemonitoring, wellness, ambient assisted living (AAL) and applications for ubiquitous-health (u-health). However, the newly emerging situations imply very strict requirements for the protocols involved in the communication. The ISO/IEEE 11073 (X73) family of standards is adapting to new personal devices, implementing high quality sensors, and supporting wireless transport (e.g. Bluetooth) and the access to faster and reliable communication network resources. Its optimized version (X73-PHD) is adequate for this new technology snapshot and might appear the best-positioned international standards to reach this goal. This work presents an updated survey of this standard and its implementation in a middleware telemonitoring platform.
Skin-to-Skin Contact Improves Gas Exchange in Premature Infants

OBJECTIVE:Skin-to-skin contact (kangarooing) is regarded as an important method to improve intensive care in premature infants. There is still demand for investigations of its impact on physiological parameters.STUDY DESIGN:We examined 53 preterm infants of <1800 gm in a prospective, pretest-test-posttest design study during incubator care (60 minutes), skin-to-skin contact (90 minutes), and incubator care again (90 minutes). Heart rate, respiratory rate, oxygen saturation (SaO2), transcutaneous pO2 (tcpO2), transcutaneous pCO2, rectal temperature, and fraction of inspired oxygen were measured.RESULTS:The heart rate increased during skin-to-skin contact by 5 beats per minute (p < 0.001), the respiratory rate dropped by 5/minute (p < 0.01), the SaO2 improved by 0.4% (p < 0.05) accompanied by an increase of tcpO2 of 4.8 mm Hg (p < 0.001), the tcpCO2 dropped by 1.2 mm Hg (p < 0.001), and the rectal temperature increased by 0.3 ° C (p < 0.001). Analyzing three groups separately by postnatal weight, we observed the smallest increase in heart rate and the highest decrease in respiratory rate in infants of <1000 gm (p < 0.001). The increase in SaO2 and in the tcpO2 doubles in infants of <1000 gm compared with infants of >1000 gm (p < 0.001). All changes were independent of postnatal age.CONCLUSION: During skin-to-skin contact, preterm infants not only remain clinically stable but also show a more efficient gas exchange. Although the patient is removed (transferred) from the incubator, there is no risk of hypothermia even in infants of <1000 gm.
Moodbile: A Framework to Integrate m-Learning Applications with the LMS

Learning Management Systems (LMS) have become widespread among most centres for education and training. Being a mature technology, LMS have left the vanguard of innovation. Educational usages of the Web 2.0, Personal Learning Environments, Game-based Learning and particularly the introduction of mobile phones and tablets in education are happening outside the boundaries of the LMS. This paper proposes a way to integrate mobile devices and educational applications with the LMS through webservices; introducing the Moodbile project that provides an extension of Moodle 2.0 webservices for mobile integration and two mobile clients ready to use on real courses. ACM classification: K.3 (computers in education), D.2.12 (Interoperability), D.2.11 (Software Archi tectures)
Effect of Compound Zhebei Granule () combined with chemotherapy on surface markers of leukemia stem cell in patients with acute myeloid leukemia.

OBJECTIVE
To observe the effects of Compound Zhebei Granule (, CZBG) combined with chemotherapy on surface markers of leukemia stem cell (LSC) in the bone marrow of patients with acute myeloid leukemia (AML).


METHODS
Seventy-eight patients with AML received bone marrow aspiration and the percentages of CD34(+) CD123(+) and CD33(+) CD123(+) cells were tested using flow cytometry method. A total of 24 refractory or relapsed AML patients were enrolled and treated with one cycle of standard chemotherapy combined with CZBG. Bone marrow samples were obtained before and after treatment, and the percentages of CD34(+) CD123(+) and CD33(+) CD123(+) cells were examined by flflow cytometry.


RESULTS
Compared with refractory or relapsed AML patients, patients achieved remission had a significant lower percentage of CD34(+) CD123(+) cells(P<0.01) and CD33(+) CD123(+) cells (P<0.01), indicating that controlling the LSC percentage may be important for patients with AML to achieve sustainable remission. Compared with those before treatment, the expression levels of CD34(+) CD123(+) were significantly decreased after CZBG combined with chemotherapy treatment (P<0.01). The percentages of CD34(+) CD123(+) cells and CD33(+) CD123(+) in patients achieving complete remission after CZBG combined with chemotherapy treatment were both significantly lower than those in patients with nonremission (P<0.01).


CONCLUSION
CZBG combining chemotherapy could reduce the percentages of CD34(+) CD123(+) and CD33(+) CD123(+) LSC, which might improve the clinical efficacy of refractory or relapsed AML.
ECISER: Efficient Clip-art Image SEgmentation by Re-rasterization

a r t i c l e i n f o
International subarachnoid aneurysm trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised comparison of effects on survival, dependency, seizures, rebleeding, subgroups, and aneurysm occlusion

BACKGROUND
Two types of treatment are being used for patients with ruptured intracranial aneurysms: endovascular detachable-coil treatment or craniotomy and clipping. We undertook a randomised, multicentre trial to compare these treatments in patients who were suitable for either treatment because the relative safety and efficacy of these approaches had not been established. Here we present clinical outcomes 1 year after treatment.


METHODS
2143 patients with ruptured intracranial aneurysms, who were admitted to 42 neurosurgical centres, mainly in the UK and Europe, took part in the trial. They were randomly assigned to neurosurgical clipping (n=1070) or endovascular coiling (n=1073). The primary outcome was death or dependence at 1 year (defined by a modified Rankin scale of 3-6). Secondary outcomes included rebleeding from the treated aneurysm and risk of seizures. Long-term follow up continues. Analysis was in accordance with the randomised treatment.


FINDINGS
We report the 1-year outcomes for 1063 of 1073 patients allocated to endovascular treatment, and 1055 of 1070 patients allocated to neurosurgical treatment. 250 (23.5%) of 1063 patients allocated to endovascular treatment were dead or dependent at 1 year, compared with 326 (30.9%) of 1055 patients allocated to neurosurgery, an absolute risk reduction of 7.4% (95% CI 3.6-11.2, p=0.0001). The early survival advantage was maintained for up to 7 years and was significant (log rank p=0.03). The risk of epilepsy was substantially lower in patients allocated to endovascular treatment, but the risk of late rebleeding was higher.


INTERPRETATION
In patients with ruptured intracranial aneurysms suitable for both treatments, endovascular coiling is more likely to result in independent survival at 1 year than neurosurgical clipping; the survival benefit continues for at least 7 years. The risk of late rebleeding is low, but is more common after endovascular coiling than after neurosurgical clipping.
Scan Statistics on Enron Graphs

We introduce a theory of scan statistics on graphs and apply the ideas to the problem of anomaly detection in a time series of Enron email graphs. Corresponding author: Carey E. Priebe = <cep@jhu.edu>
The concurrent application of lean production and ERP: Towards an ERP-based lean implementation process

Lean production and enterprise resource planning systems are often quoted as being the two most important strategies for achieving competitive advantage in today’s global manufacturing environments. Though IT has traditionally been viewed as a contributor to waste within lean production, we suggest that modern developments in IT and the onset of hybrid ‘‘push-pull’’ production control mechanisms have allowed ERP and lean approaches to converge towards a state where ERP systems can in fact be used to support the deployment of lean practices. This paper analyses typical lean and ERP implementation processes contained within the scientific literature, and by further examining a concurrent implementation process in real-time, we develop and propose a process for ERP-based lean implementations. Our findings suggest that the implementation of a contemporary ERP system can act as a catalyst for the application of lean production practices. 2012 Elsevier B.V. All rights reserved. * Corresponding author. Tel.: +47 73593983. E-mail address: daryl.j.powell@ntnu.no (D. Powell).