LLukas22/scidocs huggingface dataset:
Anti-JCV Antibodies Detection and JCV DNA Levels in PBMC, Serum and Urine in a Cohort of Spanish Multiple Sclerosis Patients Treated with Natalizumab

One of the most effective multiple sclerosis (MS) treatment is natalizumab. Nevertheless, it has been associated with an increased risk of progressive multifocal leukoencephalopathy (PML) caused by the JC virus (JCV). Our main objective was to assess the utility of testing JCV-DNA, apart from anti-JCV antibodies, to determine which natalizumab-treated MS patients has been previously in contact with the virus. For this purpose, 138 MS natalizumab/non-natalizumab treated patients participated in several studies. Cross-sectional study (CS): association of several epidemiological variables with anti-JCV antibodies and JCV-DNA levels in PBMC/serum/urine. First longitudinal study (A): evaluation of JCV-DNA prevalence in urine throughout the treatment. Second longitudinal study (B): simultaneous assessment of antibodies and viral DNA levels in PBMC/serum/urine at two time points. CS: The seropositivity rate for anti-JCV antibodies (62.3 %) and JCV prevalence in urine (59.4 %) were similar; although 26 % of our population was positive only using one of the two techniques. A: The viral prevalence in urine seemed to increase between the baseline visit and the others (Baseline-Visit/V18months, p = 0.006). B: Our rate of positive antibody seroconversion was 36 %. Nearly all patients with detectable JCV-DNA levels in PBMC excreted the virus intermittently in urine; while our PML case, positive in PBMC and serum samples 2 month before the PML, excreted JCV permanently. In conclusion, the determination of JCV DNA levels in urine could be complementary to anti-JCV antibodies for identifying MS patients who has been infected by the JCV. Further research would be necessary to understand the different JCV excretion profiles in urine.
Modeling genetic algorithms with Markov chains

We model a simple genetic algorithm as a Markov chain. Our method is both complete (selection, mutation, and crossover are incorporated into an explicitly given transition matrix) and exact; no special assumptions are made which restrict populations or population trajectories. We also consider the asymptotics of the steady state distributions as population size increases.
TWO STEP CREDIT RISK ASSESMENT MODEL FOR RETAIL BANK LOAN APPLICATIONS USING DECISION TREE DATA MINING TECHNIQUE

Data mining techniques are becoming very popular nowadays because of the wide availability of huge quantity of data and the need for transforming such data into knowledge. In today’s globalization, core banking model and cut throat competition making banks to struggling to gain a competitive edge over each other. The face to face interaction with customer is no more exists in the modern banking world. Banking systems collect huge amounts of data on day to day basis, be it customer information, transaction details like deposits and withdrawals, loans, risk profiles, credit card details, credit limit and collateral details related information. Thousands of decisions are taken in a bank on daily basis. In recent years the ability to generate, capture and store data has increased enormously. The information contained in this data can be very important. The wide availability of huge amounts of data and the need for transforming such data into knowledge encourage IT industry to use data mining. Lending is the primary business of the banks. Credit Risk Management is one of the most important and critical factor in banking world. Without proper credit risk management banks will face huge losses and lending becomes very tough for the banks. Data mining techniques are greatly used in the banking industry which helps them compete in the market and provide the right product to the right customer with less risk. Credit risks which account for the risk of loss and loan defaults are the major source of risk encountered by banking industry. Data mining techniques like classification and prediction can be applied to overcome this to a great extent. In this paper we introduce an effective prediction model for the bankers that help them predict the credible customers who have applied for loan. Decision Tree Induction Data Mining Algorithm is applied to predict the attributes relevant for credibility. A prototype of the model is described in this paper which can be used by the organizations in making the right decision to approve or reject the loan request of the customers. Keywords— Banking industry; Data Mining; Risk Management; Classification; Credit Scoring; Non-Performing Assets; Default Detection; Non-Performing Loans Decision Tree; Credit Risk Assessment; Classification; Prediction --------------------------------------------------------------------***----------------------------------------------------------
Nitric oxide–cyclic GMP pathway with some emphasis on cavernosal contractility

Nitric oxide (NO) is formed from the conversion of L-arginine by nitric oxide synthase (NOS), which exists in three isoforms: neuronal (nNOS), endothelial (eNOS), and inducible (iNOS). nNOS is expressed in penile neurons innervating the corpus cavernosum, and eNOS protein expression has been identified primarily in both cavernosal smooth muscle and endothelium. NO is released from nerve endings and endothelial cells and stimulates the activity of soluble guanylate cyclase (sGC), leading to an increase in cyclic guanosine-3′,5′-monophosphate (cGMP) and, finally, to calcium depletion from the cytosolic space and cavernous smooth muscle relaxation. The effects of cGMP are mediated by cGMP dependent protein kinases, cGMP-gated ion channels, and cGMP-regulated phosphodiesterases (PDE). Thus, cGMP effect depends on the expression of a cell-specific cGMP-receptor protein in a given cell type. Numerous systemic vasculature diseases that cause erectile dysfunction (ED) are highly associated with endothelial dysfunction, which has been shown to contribute to decreased erectile function in men and a number of animal models of penile erection. Based on the increasing knowledge of intracellular signal propagation in cavernous smooth muscle tone regulation, selective PDE inhibitors have recently been introduced in the treatment of ED. Phosphodiesterase 5 (PDE5) inactivates cGMP, which terminates NO-cGMP-mediated smooth muscle relaxation. Inhibition of PDE5 is expected to enhance penile erection by preventing cGMP degradation. Development of pharmacologic agents with this effect has closely paralleled the emerging science.
An Investigation into the Use of Logical and Rhetorical Tactics within Eristic Argumentation on the Social Web

Argumentation is a key aspect of communications and can broadly be broken down into problem solving (dialectic) and quarrelling (eristic). Techniques used within argumentation can likewise be classified as fact-based (logical), or emotion/audience-based (rhetorical). Modelling arguments on the social web is a challenge for those studying computational argumentation as formal models of argumentation tend to assume a logical argument, whereas argumentation on the social web is often largely rhetorical. To investigate the application of logical versus rhetorical techniques on the social web, we bring together two ontologies used for modelling argumentation and online communities respectively, the Argument Interchange Format and the Semantic Interlinked Online Communities project. We augment these with our own ontology for modelling rhetorical argument, the Argumentation on the Social Web Ontology, and trial our additions by examining three case studies following argumentation on different categories of social media. Finally, we present examples of how rhetorical argumentation is used in the context of the social web and show that there are clear markers present that can allow for a rudimentary estimate for the classification of a social media post with regards to its contribution to a discussion.
Learning to Play the Game of Chess

This paper presents NeuroChess, a program which learns to play chess from the final outcome of games. NeuroChess learns chess board evaluation functions, represented by artificial neural networks. It integrates inductive neural network learning, temporal differencing, and a variant of explanation-based learning. Performance results illustrate some of the strengths and weaknesses of this approach.
Politics and Philosophy in Plato's Menexenus: Education and rhetoric, myth and history

Introduction Part 1: The Menexenus, its Persons, its Problems 1. Synopsis of the dialogue 2. Persons and dates of the dialogue 3. The Athenian funeral speech 4. The Menexenus as parody, as improvement Part 2: Education and Rhetoric 5. Scenes of instruction: Pericles' missed opportunities 6. Philosophical rhetoric Part 3: Myth and History 7. Myth 8. History. Index
Fabrication and performance of endoscopic ultrasound radial arrays based on PMN-PT single crystal/epoxy 1-3 composite

In this paper, 0.7Pb(Mg1/3Nb2/3)O3-0.3PbTiO3 (PMN-PT) single crystal/epoxy 1/3 composite was used as the active material of the endoscopic ultrasonic radial array transducer, because this composite exhibited ultrahigh electromechanical coupling coefficient (kt = 0.81%), very low mechanical quality factor (Qm = 11) and relatively low acoustic impedance (Zt = 12 MRayls). A 6.91 MHz PMN-PT/epoxy 1/3 composite radial array transducer with 64 elements was tested in a pulseecho response measurement. The -6-dB bandwidth of the composite array transducer was 102%, which was ~30% larger than that of traditional lead zirconate titanate array transducer. The two-way insertion loss was found to be -32.3 dB. The obtained results show that this broadband array transducer is promising for acquiring high-resolution endoscopic ultrasonic images in many clinical applications.
Reliability and validity of Somali version of the PHQ-9 in primary care practice.

Objectives Depression is one of the common mental health problems noticed in immigrants because of the experiences related to their resettlement which is the case for Somali population. Depression increases mortality, morbidity, disability, and costs of health care which can be controlled by screening depression in the primary care setting using a culturally and linguistically congruent screening tool. The aim of the current study is to translate the English PHQ-9 into Somali language using evidence-based translational methodology and establish psychometric properties of the Somali PHQ-9. Methods The initial validation of the Somali PHQ-9 was studied by comparing the original and back translation versions using the comparability and interpretability tool in a sample of 56 monolingual health care professionals. The reliability and validity of the Somali version were established by psychometric analysis in a sample of 47 bilingual health-care workers. Results Cronbach's alpha was 0.79 for the Somali version with the inter-item correlation mean of 0.33 and item-to-total correlation mean in the range of 0.40-0.80 ( p < 0.01). Pearson correlation for the item-to-item correlation between English and Somali version was between 0.70 and 0.93 ( p < 0.01) with the paired t-test showing no significant difference between the item means. Conclusions The Somali PHQ-9 showed a good reliability, homogeneity, and internal consistency. The construct validity for the Somali PHQ-9 was also established showing that the Somali PHQ-9 has similar reliability and validity like the other translated versions of PHQ-9.
A 1.2 V, Inductorless, Broadband LNA in 90 nm CMOS LP

This paper presents a novel broadband, inductorless, resistive-feedback CMOS LNA. The LNA is designed for the frequency band 0.4 - 1 GHz. The measured power gain of the LNA is 16 dB at 1 GHz and the 3-dB bandwidth is 2 GHz. A noise figure of 3.5 dB and an IIP3 of -17 dBm are measured at 900 MHz. The S11 is better than -10 dB in the frequency band from 300 MHz up to 1 GHz. The current consumption is 14 mA from a 1.2 V supply. The circuit is designed in a baseline CMOS 90 nm low power (LP) process.
Stock Market Responses to Unethical Behavior in Organizations: An Organizational Context Model

We develop and test a model that extends the understanding of how people react to news of organizational unethical behavior and how such reactions impact stock performance. We do so by taking into ...
Breastfeeding and lung function at school age: does maternal asthma modify the effect?

RATIONALE
The evidence for an effect of breastfeeding on lung function is conflicting, in particular whether the effect is modified by maternal asthma.


OBJECTIVES
To explore the association between breastfeeding and school-age lung function.


METHODS
In the Leicestershire Cohort Studies we assessed duration of breastfeeding (not breastfed, ≤3 months, 4-6 months, and >6 months), other exposures, and respiratory symptoms by repeated questionnaires. Post-bronchodilator FVC, FEV(1), peak expiratory flow (PEF), forced midexpiratory flow (FEF(50)), and skin prick tests were measured at age 12 years. We performed multivariable linear regression and tested potential causal pathways (N = 1,458).


MEASUREMENTS AND MAIN RESULTS
In the entire sample, FEF(50) was higher by 130 and 164 ml in children breastfed for 4 to 6 months and longer than 6 months, respectively, compared with those not breastfed (P = 0.048 and 0.041), with larger effects if the mother had asthma. FVC and FEV(1) were associated with breastfeeding only in children of mothers with asthma (P for interaction, 0.018 and 0.008): FVC was increased by 123 and 164 ml for those breastfed 4 to 6 months or longer than 6 months, respectively (P = 0.177 and 0.040) and FEV(1) was increased by 148 and 167 ml, respectively (P = 0.050 and 0.016). Results were unchanged after adjustment for respiratory infections in infancy and asthma and atopy in the child.


CONCLUSIONS
In this cohort, breastfeeding for more than 4 months was associated with increased FEF(50) and, in children of mothers with asthma, with increased FEV(1) and FVC. It seems that the effect is not mediated via avoidance of early infections or atopy but rather through a direct effect on lung growth.
Height predicts jealousy differently for men and women

Because male height is associated with attractiveness, dominance, and reproductive success, taller men may be less jealous. And because female height has a curvilinear relationship with health and reproductive success (with average-height females having the advantages), female height may have a curvilinear relationship with jealousy. In Study 1, male height was found to be negatively correlated with self-reported global jealousy, whereas female height was curvilinearly related to jealousy, with average-height women reporting the lowest levels of jealousy. In Study 2, male height was found to be negatively correlated with jealousy in response to socially influential, physically dominant, and physically attractive rivals. Female height was negatively correlated with jealousy in response to physically attractive, physically dominant, and high-social-status rivals; in addition, quadratic effects revealed that approximately average-height women tend to be less jealous of physically attractive rivals but more jealous of rivals with “masculine” characteristics of physical dominance and social status. © 2008 Elsevier Inc. All rights reserved.
BamTools: a C++ API and toolkit for analyzing and managing BAM files

MOTIVATION
Analysis of genomic sequencing data requires efficient, easy-to-use access to alignment results and flexible data management tools (e.g. filtering, merging, sorting, etc.). However, the enormous amount of data produced by current sequencing technologies is typically stored in compressed, binary formats that are not easily handled by the text-based parsers commonly used in bioinformatics research.


RESULTS
We introduce a software suite for programmers and end users that facilitates research analysis and data management using BAM files. BamTools provides both the first C++ API publicly available for BAM file support as well as a command-line toolkit.


AVAILABILITY
BamTools was written in C++, and is supported on Linux, Mac OSX and MS Windows. Source code and documentation are freely available at http://github.org/pezmaster31/bamtools.
Pop-up assembly of 3 D structures actuated by heat shrinkable polymers

Folding 2D sheets into desired 3D structures is a promising fabrication technique that can find a wide range of applications. Compressive buckling provides an attractive strategy to actuate the folding and can be applied to a broad range of materials. Here a new and simple method is reported to achieve controlled compressive buckling, which is actuated by a heat shrinkable polymer sheet. The buckling deformation is localized at the pre-defined creases in the 2D sheet, resulting in sharp folding. Two approaches are developed to actuate the transformation, which follow similar geometric rules. In the first approach, the 2D precursor is pushed from outside, which leads to a 3D structure surrounded by the shrunk polymer sheet. Assembled 3D structures include prisms/pyramids with different base shapes, house roof, partial soccer ball, Miura-ori structure and insect wing. In the second approach, the 2D precursor is pulled from inside, which leads to a 3D structure enclosing the shrunk polymer sheet. Prisms/pyramids with different base shapes are assembled. The assembled structures are further tessellated to fabricate cellular structures that can be used as thermal insulator and crash energy absorber. They are also stacked vertically to fabricate complex multilayer structures. Supplementary material for this article is available online
A Guide to Protein Isolation

The best ebooks about Guide To Protein Isolation that you can get for free here by download this Guide To Protein Isolation and save to your desktop. This ebooks is under topic such as how to isolate proteins a guide to protein isolation home springer guide to protein isolation ebmplc a guide to protein isolation, 2003, 249 pages, c dennison guide to protein isolation lanemb thermo scientific pierce protein purification technical protein purification wolfson centre home page protein purification and analysis protocols and green fluorescent protein (gfp) purification kit bio-rad protein purification harvard university study guide for protein isolation and analysis free download a guide to protein isolation book rna purification products from macherey-nagel purification guide to protein purification mybookdir title: protein isolation and identification in genetically roche applied science the complete guide for protease thermo scientific pierce cell lysis technical handbook free download guide to protein purification book biotechnology explorer green fluorescent protein (gfp the c mplete guide for protease inhibition huji methods in enzymology guide to protein purification gbv thermo scientific avidin-biotin technical handbook guide to protein purification authors pdf format guide to protein purification, 2009, 900 pages, richard r guide to protein purification, vol 463 edition no 2 dna purification protocols and applications guide t13e a guide to soy protein milkproductsinc detergents and solubilization reagents example protein isolation and purification assay guide to solid phase extraction genetics, dna and protein synthesis study guide protein extraction cell fractionation dna extraction ez-rna ii product description 2015igem
Manual treatment for cervicogenic headache and active trigger point in the sternocleidomastoid muscle: a pilot randomized clinical trial.

OBJECTIVE
The purpose of this preliminary study was to determine feasibility of a clinical trial to measure the effects of manual therapy on sternocleidomastoid active trigger points (TrPs) in patients with cervicogenic headache (CeH).


METHODS
Twenty patients, 7 males and 13 females (mean ± SD age, 39 ± 13 years), with a clinical diagnosis of CeH and active TrPs in the sternocleidomastoid muscle were randomly divided into 2 groups. One group received TrP therapy (manual pressure applied to taut bands and passive stretching), and the other group received simulated TrP therapy (after TrP localization no additional pressure was added, and inclusion of longitudinal stroking but no additional stretching). The primary outcome was headache intensity (numeric pain scale) based on the headaches experienced in the preceding week. Secondary outcomes included neck pain intensity, cervical range of motion (CROM), pressure pain thresholds (PPT) over the upper cervical spine joints and deep cervical flexors motor performance. Outcomes were captured at baseline and 1 week after the treatment.


RESULTS
Patients receiving TrP therapy showed greater reduction in headache and neck pain intensity than those receiving the simulation (P < .001). Patients receiving the TrP therapy experienced greater improvements in motor performance of the deep cervical flexors, active CROM, and PPT (all, P < .001) than those receiving the simulation. Between-groups effect sizes were large (all, standardized mean difference, >0.84).


CONCLUSION
This study provides preliminary evidence that a trial of this nature is feasible. The preliminary findings show that manual therapy targeted to active TrPs in the sternocleidomastoid muscle may be effective for reducing headache and neck pain intensity and increasing motor performance of the deep cervical flexors, PPT, and active CROM in individuals with CeH showing active TrPs in this muscle. Studies including greater sample sizes and examining long-term effects are needed.
Development of A Computerized Biometric Control Examination Screening And Attendance Monitoring System With Fees Management

Examination is one of the ways to assess the receptiveness of student to various class teachings in various schools or institutions from primary to post primary and tertiary institutions. But this is not without problem like impersonation, student class absenteeism and debtor student sitting for examination especially in private institutions. The proposed system developed with the aim of solving stated problems. The system did not only has the ability to take student class attendance and screening before and after examination but it can also be used to verify whether such student is in debit to the institution or whether the student has paid required percentage of the tuition before being allowed to sit for the examination thereby reducing number of student in debit before examination started, it will also eliminate impersonation during examination and stress of manual class attendance taking and record keeping, also avoid writing of name of absent student unlike in manual process of class attendance. The system will also make it easier to calculate required percentage of class attendance before any student is allowed to sit for an examination in any institution. The system adopted biometric access control techniques, which is designed with extended graphical user interface by using Microsoft visual studio 2010 and integrated with Microsoft fingerprint reader. The student information is stored by MySQL which serve as database located in the user's computer or server. KeywordsBiometric; Fingerprint; Examination; Attendance; Tuition; Fees; Institution.