LLukas22/scidocs huggingface dataset:
Early Cannabis Use, Polygenic Risk Score for Schizophrenia and Brain Maturation in Adolescence.

IMPORTANCE
Cannabis use during adolescence is known to increase the risk for schizophrenia in men. Sex differences in the dynamics of brain maturation during adolescence may be of particular importance with regard to vulnerability of the male brain to cannabis exposure.


OBJECTIVE
To evaluate whether the association between cannabis use and cortical maturation in adolescents is moderated by a polygenic risk score for schizophrenia.


DESIGN, SETTING, AND PARTICIPANTS
Observation of 3 population-based samples included initial analysis in 1024 adolescents of both sexes from the Canadian Saguenay Youth Study (SYS) and follow-up in 426 adolescents of both sexes from the IMAGEN Study from 8 European cities and 504 male youth from the Avon Longitudinal Study of Parents and Children (ALSPAC) based in England. A total of 1577 participants (aged 12-21 years; 899 [57.0%] male) had (1) information about cannabis use; (2) imaging studies of the brain; and (3) a polygenic risk score for schizophrenia across 108 genetic loci identified by the Psychiatric Genomics Consortium. Data analysis was performed from March 1 through December 31, 2014.


MAIN OUTCOMES AND MEASURES
Cortical thickness derived from T1-weighted magnetic resonance images. Linear regression tests were used to assess the relationships between cannabis use, cortical thickness, and risk score.


RESULTS
Across the 3 samples of 1574 participants, a negative association was observed between cannabis use in early adolescence and cortical thickness in male participants with a high polygenic risk score. This observation was not the case for low-risk male participants or for the low- or high-risk female participants. Thus, in SYS male participants, cannabis use interacted with risk score vis-à-vis cortical thickness (P = .009); higher scores were associated with lower thickness only in males who used cannabis. Similarly, in the IMAGEN male participants, cannabis use interacted with increased risk score vis-à-vis a change in decreasing cortical thickness from 14.5 to 18.5 years of age (t137 = -2.36; P = .02). Finally, in the ALSPAC high-risk group of male participants, those who used cannabis most frequently (≥61 occasions) had lower cortical thickness than those who never used cannabis (difference in cortical thickness, 0.07 [95% CI, 0.01-0.12]; P = .02) and those with light use (<5 occasions) (difference in cortical thickness, 0.11 [95% CI, 0.03-0.18]; P = .004).


CONCLUSIONS AND RELEVANCE
Cannabis use in early adolescence moderates the association between the genetic risk for schizophrenia and cortical maturation among male individuals. This finding implicates processes underlying cortical maturation in mediating the link between cannabis use and liability to schizophrenia.
A coordination architecture for spacecraft formation control

This paper addresses the problem of coordinating multiple spacecraft to fly in tightly controlled formations. The main contribution of the paper is to introduce a coordination architecture that subsumes leader-following, behavioral, and virtual-structure approaches to the multiagent coordination problem. The architecture is illustrated through a detailed application of the ideas to the problem of synthesizing a multiple spacecraft interferometer in deep space.
Treadmill exercise activates subcortical neural networks and improves walking after stroke: a randomized controlled trial.

BACKGROUND AND PURPOSE
Stroke often impairs gait thereby reducing mobility and fitness and promoting chronic disability. Gait is a complex sensorimotor function controlled by integrated cortical, subcortical, and spinal networks. The mechanisms of gait recovery after stroke are not well understood. This study examines the hypothesis that progressive task-repetitive treadmill exercise (T-EX) improves fitness and gait function in subjects with chronic hemiparetic stroke by inducing adaptations in the brain (plasticity).


METHODS
A randomized controlled trial determined the effects of 6-month T-EX (n=37) versus comparable duration stretching (CON, n=34) on walking, aerobic fitness and in a subset (n=15/17) on brain activation measured by functional MRI.


RESULTS
T-EX significantly improved treadmill-walking velocity by 51% and cardiovascular fitness by 18% (11% and -3% for CON, respectively; P<0.05). T-EX but not CON affected brain activation during paretic, but not during nonparetic limb movement, showing 72% increased activation in posterior cerebellar lobe and 18% in midbrain (P<0.005). Exercise-mediated improvements in walking velocity correlated with increased activation in cerebellum and midbrain.


CONCLUSIONS
T-EX improves walking, fitness and recruits cerebellum-midbrain circuits, likely reflecting neural network plasticity. This neural recruitment is associated with better walking. These findings demonstrate the effectiveness of T-EX rehabilitation in promoting gait recovery of stroke survivors with long-term mobility impairment and provide evidence of neuroplastic mechanisms that could lead to further refinements in these paradigms to improve functional outcomes.
Accelerating the Nonuniform Fast Fourier Transform

The nonequispaced Fourier transform arises in a variety of application areas, from medical imaging to radio astronomy to the numerical solution of partial differential equations. In a typical problem, one is given an irregular sampling of N data in the frequency domain and one is interested in reconstructing the corresponding function in the physical domain. When the sampling is uniform, the fast Fourier transform (FFT) allows this calculation to be computed in O(N logN) operations rather than O(N2) operations. Unfortunately, when the sampling is nonuniform, the FFT does not apply. Over the last few years, a number of algorithms have been developed to overcome this limitation and are often referred to as nonuniform FFTs (NUFFTs). These rely on a mixture of interpolation and the judicious use of the FFT on an oversampled grid [A. Dutt and V. Rokhlin, SIAM J. Sci. Comput., 14 (1993), pp. 1368–1383]. In this paper, we observe that one of the standard interpolation or “gridding” schemes, based on Gaussians, can be accelerated by a significant factor without precomputation and storage of the interpolation weights. This is of particular value in twoand threedimensional settings, saving either 10dN in storage in d dimensions or a factor of about 5–10 in CPU time (independent of dimension).
Assessing the Prerequisite of Successful CSR Implementation : Are Consumers Aware of CSR Initiatives?

As a reflection of the values and ethics of firms, corporate social responsibility (CSR) has received a large amount of research attention over the last decade. A growing area of this research is the CSR–consumer relationship. Results of experimental studies indicate that consumer attitudes and purchase intentions are influenced by CSR initiatives – if consumers are aware of them. In order to create this awareness, business is increasingly turning to ‘prosocial’ marketing communications, but such campaigns is met with scepticism and their effectiveness are therefore uncertain. Consequently, researchers in the field (for example, Maignan, 2001; Mohr et al., 2001) have called for empirical studies to determine the level of actual consumer awareness of CSR initiatives. This study examines the Australian banking sector, which engages in and promotes its CSR activities, to help fill this gap. Results from our qualitative study with bank managers, and our quantitative study with consumers, indicate low consumer CSR awareness levels. Consumer understanding of many of the social issues banks engage with is also low. While CSR is effective in eliciting favourable consumer attitudes and behaviour in theory, CSR has not proven its general effectiveness in the marketplace. The low consumer awareness of the various social issues in which firms engage with their CSR programs suggests that firms may need to educate consumers, so they may better contextualise CSR initiatives communicated. However, better context may amount to little if claimed CSR initiatives are perceived as inconsistent with other facets of the business that reflect its
A secure light weight scheme for user authentication and key agreement in multi-gateway based wireless sensor networks

Wireless sensor networks can be deployed in any attended or unattended environments like environmental monitoring, agriculture, military, health care etc., where the sensor nodes forward the sensing data to the gateway node. As the sensor node has very limited battery power and cannot be recharged after deployment, it is very important to design a secure, effective and light weight user authentication and key agreement protocol for accessing the sensed data through the gateway node over insecure networks. Most recently, Turkanovic et al. proposed a light weight user authentication and key agreement protocol for accessing the services of the WSNs environment and claimed that the same protocol is efficient in terms of security and complexities than related existing protocols. In this paper, we have demonstrated several security weaknesses of the Turkanovic et al. protocol. Additionally, we have also illustrated that the authentication phase of the Turkanovic et al. is not efficient in terms of security parameters. In order to fix the above mentioned security pitfalls, we have primarily designed a novel architecture for the WSNs environment and basing upon which a proposed scheme has been presented for user authentication and key agreement scheme. The security validation of the proposed protocol has done by using BAN logic, which ensures that the protocol achieves mutual authentication and session key agreement property securely between the entities involved. Moreover, the proposed scheme has simulated using well popular AVISPA security tool, whose simulation results show that the protocol is SAFE under OFMC and CL-AtSe models. Besides, several security issues informally confirm that the proposed protocol is well protected in terms of relevant security attacks including the above mentioned security pitfalls. The proposed protocol not only resists the above mentioned security weaknesses, but also achieves complete security requirements including specially energy efficiency, user anonymity, mutual authentication and user-friendly password change phase. Performance comparison section ensures that the protocol is relatively efficient in terms of complexities. The security and performance analysis makes the system so efficient that the proposed protocol can be implemented in real-life application. © 2015 Elsevier B.V. All rights reserved.
Current management of acute bronchiolitis in Switzerland.

INTRODUCTION
Acute bronchiolitis is the most common lower respiratory tract infection in the first year of life. Current expert opinion and scientific data suggest that pharmaceutical agents have little impact on the natural course of the disease.


METHODS
Postal questionnaires were sent to all Swiss paediatricians to assess their current practice for treating acute bronchiolitis in children.


RESULTS
Of a total of 937 questionnaires, 541 (58%) were returned. Of the respondents, 422 (78%) treat children with acute bronchiolitis. Up to 99% of paediatricians used bronchodilators in the outpatient and inpatient management, either routinely (up to 62%) or occasionally (37%). Steroids were used by 41% of the respondents in outpatient management and by 57% in inpatient management. The paediatric respiratory physicians tended to use bronchodilators and corticosteroids less frequently than the general paediatricians.


CONCLUSIONS
A wide variation in the treatment of bronchiolitis was noted. Despite lack of evidence of benefit most Swiss paediatricians use pharmaceutical agents in the management of acute bronchiolitis. In particular, bronchodilators and corticosteroids were used in inpatient management in Switzerland much more frequently than recently reported for Australian paediatricians. National guidelines could be helpful in reducing the variations in the management of acute bronchiolitis in our country.
Changes in voluntary and electrically induced contractions during strength training and detraining

To elucidate the changes in neuro-muscular function during strength training and detraining, five male subjects underwent progressive isotonic strength training of their calf muscles three times a week for 8 weeks with additional detraining for the same periods. Electrically evoked twitch contractions were induced in the triceps surae muscles of each subject every 4 weeks during the training and detraining periods. At the same time, maximal voluntary isometric contractions (MVC) and the maximal girth of the calf (MGC) were measured. During the training period, MVC increased significantly from 98.4 to 129.6 Nm (31.7%, P < 0.01) for the first 4 weeks of training but MGC showed little increase. Neither of the changes correlated with each other. Twitch contraction parameters, i.e. maximal twitch torque (P t ), maximal rate of torque development (max dT/dt) and rate of relaxation (relax dT/dt) showed no statistical change. During detraining, on the contrary, a large and significant increase (22.5%, P < 0.01) was observed in max dTldt without any changes in P t and relax dT/dt. The MVC/P t showed both significant increases during training and decreases during detraining. Our data suggest that short term strength training as employed in the present study does not induce changes in the contractile properties of the muscle during training, but may significantly affect the rate of force development during the subsequent detraining period, indicating the possible existence of complex post-training muscle adaptation.
Validity and Reliability of the Fear-Avoidance Beliefs Questionnaire (FABQ) in Workers with Upper Extremity Injuries

Introduction Fear Avoidance Beliefs (FAB) have been associated with increased pain, dysfunction and difficulty returning to work in Upper Extremity (UE) injures. The FABQ is used to assess FAB, but its measurement properties have not been established in UE. The purpose of this study is to evaluate the reliability and validity of the FABQ to screen UE compensated injured workers for FAB. Methods Consenting workers attending a specialty clinic completed a modified FABQ, QuickDASH (Disability), SPADI Pain Score and von Korff Chronic Pain Grade (Pain), SF-36v2 (General Health), and Work Instability Scale (Job Instability). A sub-sample of workers (n = 48) completed the FABQ 2 weeks later for test–retest reliability. Results 187 workers; 54.0% male; mean age 45.2 (sd 9.68); 56% were currently working. Mean subscale scores (FABQ-Work [FABQ-W]/FABQ-Physical Activity [FABQ-PA]) were 35/42 and 20/24. Ceiling effects (23%/38%) existed in both subscales. Cronbach’s alphas were 0.75/0.78. Test–retest analysis (ICC(2,1)) was lower than desired (0.52/0.59). Construct validation was supported by a moderate correlation between FABQ-W/FABQ-PA and QuickDASH Work Module (0.51/0.42) and WIS (0.46/0.38) in those currently working. Low correlations were found between the subscales measures of pain (SPADI: 0.24/0.23; Chronic Pain Grade: 0.25/0.25), and SF-36 MCS (−0.25/−0.30). Conclusions Although FAB is an important concept to measure in compensated UE injured workers, the FABQ had limitations in this population as there was a high ceiling effect, and lower than desired reliability for individual discrimination. A priori hypotheses around construct validity were rejected for 16/22 concepts tested.
Gender differences in the occurrence of farm related injuries.

AIMS
To use national surveillance data in Canada to describe gender differences in the pattern of farm fatalities and severe injuries (those requiring hospitalisation).


METHODS
Data from the Canadian Agricultural Injury Surveillance Program (CAISP) included farm work related fatalities from 1990 to 1996 for all Canadian provinces and abstracted information from hospital discharge records from eight provinces for the five fiscal years of 1990 to 1994. Gender differences in fatalities and injuries were examined by comparison of proportions and stratified by sex, injury class (machinery, non-machinery), and age group.


RESULTS
Over the six year period of 1990 to 1996 there were approximately 11 times as many agriculture related fatalities for males compared to females (655 and 61, respectively). The most common machinery mechanisms of fatal injuries were roll-over (32%) for males and run-over (45%) for females. Agricultural machinery injuries requiring hospitalisation showed similar patterns, with proportionally more males over age 60 injured. The male:female ratio for non-machinery hospitalisations averaged 3:1. A greater percentage of males were struck by or caught against an object, whereas for females, animal related injuries predominated.


CONCLUSIONS
Gender is an important factor to consider in the interpretation of fatal and non-fatal farm injuries. A greater number of males were injured, regardless of how the occurrence of injury was categorised, particularly when farm machinery was involved. As women increasingly participate in all aspects of agricultural production, there is a need to collect, interpret, and disseminate information on agricultural injury that is relevant for both sexes.
Classification and characteristics of Japanese patients with antineutrophil cytoplasmic antibody-associated vasculitis in a nationwide, prospective, inception cohort study

INTRODUCTION
We investigated the clinical and serological features of patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in Japan using data from a nationwide, prospective, inception cohort study.


METHODS
In total, 156 Japanese patients with newly diagnosed AAV were classified according to the European Medicines Agency (EMEA) algorithm with exploratory surrogate markers for AAV-related non-granulomatous pulmonary lesions, predefined as alveolar haemorrhage and interstitial lung disease (ILD), and their clinical and serological features were evaluated.


RESULTS
Using the EMEA algorithm, we identified 14 patients (9.0%) with eosinophilic granulomatosis with polyangiitis (EGPA), 33 (21.2%) with granulomatosis with polyangiitis (GPA), 78 (50.0%) with microscopic polyangiitis and renal-limited vasculitis (MPA/RLV), and 31 (19.9%) with unclassifiable vasculitis. The average ages of patients with EGPA (male/female, 5/9), GPA (12/21), and MPA/RLV (35/43) and unclassifiable (9/22) were 58.0, 63.6, 71.1, and 70.6 years, respectively. Myeloperoxidase (MPO)-ANCA and proteinase-3 ANCA positivity was 50.0% and 0% for EGPA, 54.6% and 45.5% for GPA, 97.4% and 2.6% for MPA/RLV, and 93.5% and 3.2% for unclassifiable, respectively. According to the Birmingham Vasculitis Activity Score (BVAS), cutaneous (71.4%) and nervous system (92.9%) manifestations were prominent in EGPA and ear, nose, and throat manifestations (84.9%) and chest manifestations (66.7%) in GPA. Renal manifestations developed frequently in MPA/RLV (91.0%) and GPA (63.6%). The average serum creatinine levels were 0.71 mg/dL for EGPA, 1.51 mg/dL for GPA, 2.46 mg/dL for MPA/RLV, and 0.69 mg/dL for unclassifiable. The percentages of patients with ILD were 14.3% for EGPA, 9.0% for GPA, 47.4% for MPA/RLV, and 61.3% for unclassifiable. Patients with ILD (n = 61) had significantly lower BVAS (P = 0.019) with fewer ear, nose, and throat and cardiovascular manifestations than patients without ILD (n = 95).


CONCLUSIONS
MPO-ANCA-positive MPA/RLV is the most common form of AAV in Japanese patients, and one-half of patients with GPA were positive for MPO-ANCA. ILD is an important clinical manifestation in Japanese patients with AAV. Unclassifiable vasculitis with MPO-ANCA positivity and ILD may represent a novel variant of MPA.


TRIAL REGISTRATION
The University Hospital Medical Information Network Clinical Trials Registry: UMIN000001648. Registered 28 February 2009.
Late Quaternary dinoflagellate cyst stratigraphy at the Eurasian continental margin, Arctic Ocean: indications for Atlantic water inflow in the past 150,000 years

Four sediment cores located at the Eurasian continental margin underlying the Atlantic layer have been studied for their dinoflagellate cyst content. Concentrations of distinct dinoflagellate cyst taxa display fluctuations in the late Quaternary, which are linked to changes in the inflow of relatively warm Atlantic surface and near-surface waters, resulting in increased local production of cysts in certain time intervals. Based on the assumption that marked changes in strength of inflow occurred synchronously at the Eurasian continental margin, concentration maxima can be used to correlate sediment cores. A dinoflagellate cyst record from the northern Barents Sea continental margin has been related to the stable oxygen isotope and paleomagnetic records to provide direct chronological information. The combination of these methods permits definition of stratigraphic sections equivalent to oxygen isotope stages in carbonate-poor sequences from the Eurasian continental margin. Previous age models of sediment cores are revised, based on dinoflagellate cyst abundance peaks and species distribution, but a firm chronostratigraphy of sedimentary sequences at the eastern Laptev Sea continental margin cannot be established because of the weak signal at the sites furthest from Fram Strait. Ž . In the past 150,000 years, the influence of Atlantic subsurface waters generally decreased from west to east along the Eurasian continental margin, in particular during the glacials. Pronounced concentration maxima of cosmopolitan and temperate–subpolar dinoflagellate cysts indicate the inflow of Atlantic waters and seasonally increased production of cysts in the Holocene and Eemian. The Holocene is well-marked at the entire Eurasian continental margin but it is more difficult Ž . to assess the extent of subsurface water inflow during the Eemian, which may have only reached the western Laptev Sea continental margin. q 2001 Elsevier Science B.V. All rights reserved.
Design Practice in Human Computer Interaction Design Education

As the need for Human Computer Interaction (HCI) designers increases so does the need for courses that best prepare students for their future work life. Multidisciplinary teamwork is what very frequently meets the graduates in their new work situations. Preparing students for such multidisciplinary work through education is not easy to achieve. In this paper, we investigate ways to engage computer science students, majoring in design, use, and interaction (with technology), in design practices through an advanced graduate course in interaction design. Here, we take a closer look at how prior embodied and explicit knowledge of HCI that all of the students have, combined with understanding of design practice through the course, shape them as human-computer interaction designers. We evaluate the results of the effort in terms of increase in creativity, novelty of ideas, body language when engaged in design activities, and in terms of perceptions of how well this course prepared the students for the work practice outside of the university. Keywords—HCI education; interaction design; studio; design education; multidisciplinary teamwork.