LLukas22/scidocs huggingface dataset:
Low-dose methotrexate for the treatment of graft-versus-host disease after allogeneic hematopoietic stem cell transplantation

Summary:Methotrexate (MTX) is commonly used in the prophylaxis of graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). In order to evaluate the efficacy and safety of low-dose MTX treatment in patients with GVHD after allo-HSCT, 38 patients with acute GVHD (aGVHD), chronic GVHD (cGVHD) or GVHD post-donor lymphocyte infusion (post-DLI GVHD) after allo-HSCT received intravenous MTX at a dose of 5 or 10 mg every 5–7 days until a complete or partial response was seen, or there was treatment failure or intolerable side effects. The overall response rate was 94.7% (18/19 patients) in patients with aGVHD, 76.2% (16/21 patients) in patients with cGVHD and 2/2 in patients with post-DLI GVHD. The response rate for GVHD involving various organs was 100% in skin, 75% in gut, 55.6% in liver, 75% in mouth and 100% in the eye, among all enrolled patients. Side effects were minor. Short-term, low-dose MTX is a tolerable and an effective regimen for patients with aGVHD, cGVHD or post-DLI GVHD after allo-HSCT.
Minimally invasive lateral transpsoas approach with advanced neurophysiologic monitoring for lumbar interbody fusion

Introduction The minimally invasive, lateral, transpsoas approach for lumbar interbody fusion (extreme lateral interbody fusion, XLIF), developed in 2003, is an alternative approach to anterior lumbar interbody fusion (ALIF) [1]. The XLIF approach minimizes approach related complications common to the direct anterior approach, namely vascular and visceral injury, without the need for an access surgeon [2, 3]. In order to safely traverse the psoas muscle, which contains the nerves of the lumbosacral plexus, real-time, surgeondirected neuromonitoring (including free-run and evoked electromyography (EMG) in directional orientations with discrete-threshold responses) is used [4].
Trait Emotional Intelligence and Personality Gender-Invariant Linkages Across Different Measures of the Big Five

This study investigated if the linkages between trait emotional intelligence (trait EI) and the Five-Factor Model of personality were invariant between men and women. Five English-speaking samples (N = 307-685) of mostly undergraduate students each completed a different measure of the Big Five personality traits and either the full form or short form of the Trait Emotional Intelligence Questionnaire (TEIQue). Across samples, models predicting global TEIQue scores from the Big Five were invariant between genders, with Neuroticism and Extraversion being the strongest trait EI correlates, followed by Conscientiousness, Agreeableness, and Openness. However, there was some evidence indicating that the gender-specific contributions of the Big Five to trait EI vary depending on the personality measure used, being more consistent for women. Discussion focuses on the validity of the TEIQue as a measure of trait EI and its psychometric properties, more generally.
Public Sound Objects: A Shared Musical Space on the Web

In this paper we describe “The Public Sound Objects” project and its context. This project, which is currently under development, approaches Internet collaborative music performance, going beyond most common paradigms where the network is mainly used as a channel to provide a connection between performative spaces. The system will provide an on-line public performance space where people can be found participating in an ongoing collaborative sonic event. The users connected to this installation control a server side synthesis engine through a web-based interface. The resulting “Sound Objects” form a sonic piece that is then streamed back to each user. The user takes the role of a performer and his contribution has a direct and unique influence on the overall resulting soundscape. This ongoing event is also played back at the installation for a live audience, with added contextual elements such as sound spacialization and metaphorical visual representations of current participants.
Values of natural and human-made wetlands: A meta-analysis: VALUES OF NATURAL AND HUMAN-MADE WETLAND

[1] The values of goods and services provided by wetland ecosystems are examined through a meta‐analysis of an expanded database of wetland value estimates and with a focus on human‐made wetlands. This study extends and improves upon previous meta‐analyses of the wetland valuation literature in terms of the number of observations, geographical coverage, wetland class and integrity, and the measurement of the effects of scarcity and anthropogenic pressure. We find that water quality improvement, nonconsumptive recreation, and provision of natural habitat and biodiversity are highly valued services. Substitution effects are observed through the negative correlation between values and abundance of other wetlands. Wetland values are found to increase with anthropogenic pressure. An extended metaregression model with cross effects shows that the valuation of specific services varies with the type of wetland producing them. Human‐ made wetlands are highly valued for biodiversity enhancement, water quality improvement, and flood control.
Video Content Representation, Indexing, and Matching in Video Information Systems

graph of words, a related image. It allows a user to generate Changing between frames is one of the most obvious informaqueries containing both temporal and spatial concepts, and tion in video data. This frame-by-frame time series data is also provides content-based searching. However, how to essential to many application areas. However, how to extract extract and compare video contents in a video information and compare video contents in a video information system is system is still an important problem to be solved. still an important problem to be solved. In this paper, we focus Therefore, the problem we deal with is the design of a on the problem of design a fast searching method in a video video information system with an efficient video content information system to locate video segments that match a conrepresentation, an effective multilevel query processing tent-based query, approximately by time series feature values. capability, and a fast searching method. According our The idea is to extract video contents via low-level feature extracresearches, frame-to-frame object changing is one of the tion and/or high level semantic retrieval mechanisms according most obvious information in video data. With temporal to a specific point of view, then segment video contents into bounding boxes via a box segmentation mechanism by their extension, frame-to-frame object changing cause a series time series feature values. Video content indexing is constructed of frame-by-frame data. This frame-by-frame time series by the characteristics of prominent points that accompany data is essential to many areas, such as gesture recognition bounding boxes. We also propose an efficient and effective in human-centered information systems, dynamic indusvideo content matching algorithm to find similar sequences. trial processed monitoring, scene segmentation [1, 2], autoWith the help of the video indexing and matching mechanisms, matic object tracking, and dynamic scene understanding. several high level box-to-box and low level point-to-point query That is, the searching method should include an indexing types can be requested. The implementation and performance and a matching mechanism that can search a video informaevaluation of our video information prototype system is tion system by time-series feature values or even by multidescribed.  1997 Academic Press level semantic meanings, in order to locate video subsequences that match a query sequence approximately.
Gastroesophageal Reflux Disease Questionnaire (GerdQ) in real-world practice: a national multicenter survey on 8065 patients.

BACKGROUND AND AIM
Recently, Gastroesophageal Reflux Disease Questionnaire (GerdQ) has been developed for diagnosis of GERD. However, no study investigated its value in real-world practice. This study aimed to investigate whether GerdQ can be used for diagnosis of GERD in China.


METHODS
A national multicenter survey was undertaken; all patients who underwent first diagnostic upper endoscopy for upper gastrointestinal (GI) symptoms were included. Data including the gender, age, symptoms, and endoscopic findings were prospectively recorded. The GerdQ score was measured before endoscopic procedure.


RESULTS
Totally, 8065 patients were included. One thousand four hundred and thirty-five patients (17.8%) had reflux esophagitis. Among them, 620 (43.2%) patients' GerdQ score was ≥ 8. For 2025 patients with GerdQ ≥ 8, 620 (30.6%) were found to have reflux esophagitis, but the remaining 69.4% (1405/2025) were normal. Proportions of patients with reflux esophagitis increased in cut-off range from 3-18 for GerdQ. However, 22.2% of the patients with a GerdQ score ≤ 2 also had reflux esophagitis. Twenty-eight (0.3%) patients were diagnosed to have upper GI malignancies, and 10 out of these 28 (35.7%) patients' GerdQ score was ≥ 8.


CONCLUSIONS
The study suggests the proportions of Chinese patients with reflux esophagitis rise up with the increase of GerdQ score, and GerdQ may be used for diagnosis of GERD. However, low GerdQ score cannot exclude the possibility of reflux esophagitis. A minority of Chinese patients has high GerdQ score but is diagnosed with malignancies, even in the absence of alarm features.
Resolving threats to the therapeutic alliance in cognitive analytic therapy of borderline personality disorder: a task analysis.

BACKGROUND
Alliance ruptures and premature drop out from psychotherapy are very common with patients who have a diagnosis of borderline personality disorder, limiting the clinical effectiveness of treatment.


AIM
To test and refine a model of how therapists successfully resolve threats to the therapeutic alliance involving enactment of problematic relationship patterns in the cognitive analytic therapy of borderline personality disorder.


METHOD
Task analysis (Greenberg, 1984a) of 107 enactments from 66 sessions in four good outcome cases, compared with 35 enactments from 16 sessions in two poor outcome cases. This systematically compares a rational model of process with empirically coded transcripts of therapy sessions where independent raters have identified an alliance threat event.


RESULTS
The process stages of the rational model were observed, and 20 refinements were made, including a new process stage, heuristic principles and 'when-then' steps. Therapists were found to cycle between stages. Therapists in good outcome cases recognized the majority of these enactments and focused attention to them in contrast to poor outcome cases where therapists usually failed to notice or draw attention to the alliance threat and did not adhere to the model.


CONCLUSION
Competent resolution of alliance-threatening events is crucially dependent on therapists' ability to recognize them, and secondarily on their adherence to the principles in the refined model. The model is consistent with prior research and can be used in supervision and quality improvement strategies.
A folded loop antenna system for handsets

A unique folded loop antenna for handsets has been analyzed. The folded loop antenna is constituted by the concept of integration, by which the mode increase and small sizing are achieved. It has been shown that the folded loop antenna shaped like a half-wave folded dipole has similar structure as the balanced system and so almost no unbalanced currents flow on the ground plane as well. Thus with this structure, mitigation of the antenna performance degradation due to the body effect can be made possible. Another uniqueness of this antenna lies in the use of a two-wire transmission line for the antenna element. The antenna impedance can be adjusted flexibly by changing the parameters of the transmission line. By this means, matching can be made easy without using a balun.
LibGuides: Climate Change: Books

Find here resources to investigate the Earth Sciences in relation to climate change and other environmental processes. Paper and Electronic Books
Identification of Extracolonic Pathologies by Computed Tomographic Colonography in Colorectal Cancer Symptomatic Patients.

BACKGROUND & AIMS
Symptoms suggestive of colorectal cancer may originate outside the colorectum. Computed tomographic colonography (CTC) is used to examine the colorectum and abdominopelvic organs simultaneously. We performed a prospective randomized controlled trial to quantify the frequency, nature, and consequences of extracolonic findings.


METHODS
We studied 5384 patients from 21 UK National Health Service hospitals referred by their family doctor for the investigation of colorectal cancer symptoms from March 2004 through December 2007. The patients were assigned randomly to groups that received the requested test (barium enema or colonoscopy, n = 3574) or CTC (n = 1810). We determined the frequency and nature of extracolonic findings, subsequent investigations, ultimate diagnosis, and extracolonic cancer diagnoses 1 and 3 years after testing patients without colorectal cancer.


RESULTS
Extracolonic pathologies were detected in 959 patients by CTC (58.7%), in 42 patients by barium enema analysis (1.9%), and in no patients by colonoscopy. Extracolonic findings were investigated in 142 patients (14.2%) and a diagnosis was made for 126 patients (88.1%). Symptoms were explained by extracolonic findings in 4 patients analyzed by barium enema (0.2%) and in 33 patients analyzed by CTC (2.8%). CTC identified 72 extracolonic neoplasms, however, barium enema analysis found only 3 (colonoscopy found none). Overall, CTC diagnosed extracolonic neoplasms in 72 of 1634 patients (4.4%); 26 of these were malignant (1.6%). There were significantly more extracolonic malignancies detected than expected 1 year after examination, but these did not differ between patients evaluated by CTC (22.2/1000 person-years), barium enema (26.5/1000 person-years; P = .43), or colonoscopy (32.0/1000 person-years; P = .88).


CONCLUSIONS
More than half of the patients with symptoms of colorectal cancer are found to have extracolonic pathologies by CTC analysis. However, the proportion of patients found to have extracolonic malignancies after 1 year of CTC examination is not significantly greater than after barium enema or colonoscopy examinations. International Standard Randomised Controlled Trials no: 95152621.isrctn.com.
Microneedling in All Skin Types: A Review.

INTRODUCTION: Microneedling procedures are growing in popularity for a wide variety of skin conditions. This paper comprehensively reviews the medical literature regarding skin needling efficacy and safety in all skin types and in multiple dermatologic conditions. METHODS: A PubMed literature search was conducted in all languages without restriction and bibliographies of relevant articles reviewed. Search terms included: "microneedling," "percutaneous collagen induction," "needling," "skin needling," and "dermaroller." RESULTS: Microneedling is most commonly used for acne scars and cosmetic rejuvenation, however, treatment benefit has also been seen in varicella scars, burn scars, keloids, acne, alopecia, and periorbital melanosis, and has improved flap and graft survival, and enhanced transdermal delivery of topical products. Side effects were mild and self-limited, with few reports of post-inflammatory hyperpigmentation, and isolated reports of tram tracking, facial allergic granuloma, and systemic hypersensitivity. DISCUSS: Microneedling represents a safe, cost-effective, and efficacious treatment option for a variety of dermatologic conditions in all skin types. More double-blinded, randomized, controlled trials are required to make more definitive conclusions. J Drugs Dermatol. 2017;16(4):308-314..
Comparative Analysis of the Molecular Adjuvants and Their Binding Efficiency with CR1

There are so many obstacles in developing a vaccine or vaccine technology for diseases like cancer and human immunodeficiency virus infection. While developing vaccines that target specific infection, molecular adjuvants are indispensable. These molecular adjuvants act as a vaccine delivery vehicle to the immune system to increase the effectiveness of the specific antigens. In the present work, a computational study has been done on molecular adjuvants like IgGFc, GMCSF and C3d to find out how efficiently they are binding to CR1. Sequence, structure and mutational analysis are performed on the molecular adjuvants to understand the features important for their binding with the receptor. Results obtained from our study indicate that the adjuvant IgGFc complexed with the receptor CR1 has the best binding efficiency, which can be used further to develop better vaccine technologies.
Global sourcing and quality recalls: : An empirical study of outsourcing-supplier concentration-product recalls linkages

This paper investigates how supply chain sourcing strategies are associated with product quality recalls. In particular, the research examines how the make or buy decision (i.e., outsourcing), the use of foreign suppliers (i.e., offshore outsourcing), the relocation of production to offshore markets (i.e., offshoring) and the decision to consolidate the supply base (i.e., use few vs. several suppliers) are related to product recalls. Product recalls are serious quality failures in the supply chain that have significant and negative impact on firm performance. Product recalls are frequently connected to the increasing trend of supply chain globalization where quality control and quality standards may be less than consistent, leading to quality problems and failures. Data across multiple industries, where recalls have been widely reported, are collected and analyzed using negative binomial regression techniques. Our findings indicate that offshore outsourcing has a greater impact on recalls than offshoring, and outsourcing domestically has the least influence. Interestingly, we find that outsourcing to a smaller supplier base may lead to fewer recalls at low levels of outsourcing but can exacerbate the impact of outsourcing on recalls at high levels of outsourcing.
Citations, contexts, and humanistic discourse: Toward automatic extraction and classification

This paper examines prospects and limitations of citation studies in the humanities. We begin by presenting an overview of bibliometric analysis, noting several barriers to applying this method in the humanities. Following that, we present an experimental tool for extracting and classifying citation contexts in humanities journal articles. This tool reports the bibliographic information about each reference, as well as three features about its context(s): frequency, locationin-document, and polarity. We found that extraction was highly successful (above 85%) for three of the four journals, and statistics for the three citation figures were broadly consistent with previous research. We conclude by noting several limitations of the sentiment classifier and suggesting future areas for refinement. .................................................................................................................................................................................
Video analytics for retail

We describe a set of tools for retail analytics based on a combination of video understanding and transaction-log. Tools are provided for loss prevention (returns fraud and cashier fraud), store operations (customer counting) and merchandising (display effectiveness). Results are presented on returns fraud and customer counting.
Exenatide versus insulin glargine: a cost-effectiveness evaluation in patients with Type 2 diabetes in Switzerland.

OBJECTIVES
To investigate the long-term clinical and economic outcomes associated with exenatide versus insulin glargine as "add-on" treatments to oral therapy in individuals with Type 2 diabetes inadequately controlled with combination oral agents in the Swiss setting.


METHODS
A computer simulation model of diabetes was used to project complications, life expectancy, quality-adjusted life expectancy and direct medical costs over a 35-year time horizon. Cohort characteristics and treatment effect data were derived from a 26-week randomized clinical trial comparing exenatide and insulin glargine. Modeled treatment effects included reductions in glycosylated hemoglobin (HbA1c) by -0.99% and -1.07% and in body mass index (BMI) by -0.80 and +0.55 kg/m2 with exenatide and insulin glargine respectively. Changes in systolic blood pressure and serum lipid levels were also captured. Simulations incorporated published quality of life utilities and Swiss costs from 2006. Extensive sensitivity analyses were conducted to assess the robustness of projected outcomes. Future clinical and economic outcomes were discounted at 2.5% per annum.


RESULTS
In the base-case analysis exenatide was associated with comparable life expectancy (11,549 years versus 11,468 years) and an improvement in quality-adjusted life expectancy of 0.43 quality-adjusted life years (QALYs) versus insulin glargine over a 35-year time horizon. Exenatide was associated with a reduced cumulative incidence of most diabetes-related complications including an absolute reduction in myocardial infarction by 0.28%. Assuming an annual treatment cost of CHF 2,797.74 for exenatide, direct costs increased by CHF 8,378 per patient over the 35-year time horizon compared to insulin glargine. The resultant incremental cost-effectiveness ratio was CHF 19,450 per QALY gained for exenatide versus insulin glargine.


CONCLUSIONS
Exenatide was associated with comparable life expectancy and an improvement in quality-adjusted life expectancy versus insulin glargine over a 35-year time horizon. Based on current standards exenatide would be a cost-effective treatment alternative to insulin glargine in Switzerland for Type 2 diabetes patients inadequately controlled on oral therapy.