LLukas22/scidocs huggingface dataset:
Multilevel analysis of the determinants of the global assessment of functioning in an inpatient population

BACKGROUND
The Global Assessment of Functioning (GAF) is a widely used measure of psychiatric symptoms and functioning, yet numerous concerns persist about its reliability and validity. The objective of this study was to determine the extent to which GAF scores reflect physician-related differences in addition to information about patients.


METHODS
This is a secondary analysis of clinical data collected between 2005 and 2010 from inpatients at a psychiatric hospital (N = 1,852). Multilevel modeling was used to estimate the influence of physicians on GAF scores at admission and on the change between admission and discharge, controlling for patient clinical presentation.


RESULTS
Controlling for patient-level predictors, 7% of the residual variance in admission GAF scores and 8% of the residual variance in change scores was at the physician level. The physician-level variance was significantly larger than zero in both models.


CONCLUSIONS
Although statistically significant, estimates of physician-level variance were not overwhelming, suggesting that the GAF was rated in a consistent manner across physicians in this hospital. While results lend support to the utility of the GAF for drawing comparisons between patients seen by different physicians across a large institution, further study is necessary to determine generalizability and to assess differences across multiple institutions.
Novel biodegradable composite wound dressings with controlled release of antibiotics: microstructure, mechanical and physical properties.

Wound dressings aim to restore the milieu required for skin regeneration and protect the wound from environmental threats, including penetration of bacteria. The dressings should be easy to apply and remove and maintain a moist healing environment. In this study, novel biodegradable composite wound dressings based on a polyglyconate mesh and a porous PDLGA binding matrix were developed and studied. These novel dressings were prepared by dip-coating woven meshes in inverted emulsions, followed by freeze-drying. Their investigation focused on the microstructure, mechanical and physical properties, and the release profile of the antibiotic drug ceftazidime from the binding matrix. The mechanical properties of our wound-dressing structures were found to be superior, combining relatively high tensile strength and ductility, which changed only slightly during 3 weeks of incubation in an aqueous medium. The parameters of the inverted emulsion, the organic-aqueous phase ratio, and the type of surfactant used for stabilizing the emulsion were found to affect the microstructure of the binding matrix and the resulting properties, i.e., water absorbance, water vapor transmission rate, and drug-release profile from the binding matrix. Appropriate selection of these parameters can yield composite structures that have the desired physical properties and drug release behavior. Thus, these unique structures are potentially very useful as burn and ulcer dressings.
Beta1-Adrenoceptor Polymorphism Predicts Flecainide Action in Patients with Atrial Fibrillation

BACKGROUND
Antiarrhythmic action of flecainide is based on sodium channel blockade. Beta(1)-adrenoceptor (beta(1)AR) activation induces sodium channel inhibition, too. The aim of the present study was to evaluate the impact of different beta(1)AR genotypes on antiarrhythmic action of flecainide in patients with structural heart disease and atrial fibrillation.


METHODOLOGY/PRINCIPAL FINDINGS
In 145 subjects, 87 with atrial fibrillation, genotyping was performed to identify the individual beta(1)AR Arg389Gly and Ser49Gly polymorphism. Resting heart rate during atrial fibrillation and success of flecainide-induced cardioversion were correlated with beta(1)AR genotype. The overall cardioversion rate with flecainide was 39%. The Arg389Arg genotype was associated with the highest cardioversion rate (55.5%; OR 3.30; 95% CI; 1.34-8.13; p = 0.003) compared to patients with Arg389Gly (29.5%; OR 0.44; 95% CI; 0.18-1.06; p = 0.066) and Gly389Gly (14%; OR 0.24; 95% CI 0.03-2.07; p = 0.17) variants. The single Ser49Gly polymorphism did not influence the conversion rate. In combination, patients with Arg389Gly-Ser49Gly genotype displayed the lowest conversion rate with 20.8% (OR 0.31; 95% CI; 0.10-0.93; p = 0.03). In patients with Arg389Arg variants the heart rate during atrial fibrillation was significantly higher (110+/-2.7 bpm; p = 0.03 vs. other variants) compared to Arg389Gly (104.8+/-2.4 bpm) and Gly389Gly (96.9+/-5.8 bpm) carriers. The Arg389Gly-Ser49Gly genotype was more common in patients with atrial fibrillation compared to patients without atrial fibrillation (27.6% vs. 5.2%; HR 6.98; 95% CI; 1.99-24.46; p<0.001).


CONCLUSIONS
The beta(1)AR Arg389Arg genotype is associated with increased flecainide potency and higher heart rate during atrial fibrillation. The Arg389Gly-Ser49Gly genotype might be of predictive value for atrial fibrillation.
Asynchronous Stochastic Approximation and Q-Learning

We provide some general results on the convergence of a class of stochastic approximation algorithms and their parallel and asynchronous variants. We then use these results to study the Q-learning algorithm, a reinforcement learning method for solving Markov decision problems, and establish its convergence under conditions more general than previously available.
Does relationship quality matter in e-services? A comparison of online and offline retailing

The quality of the relationship between customers and service firms has been found to be a major driver of customer loyalty in traditional (i.e., offline) service contexts. The increasing use of electronic services, or e-services, raises questions concerning the extent to which the relationship quality-customer loyalty link holds in an e-service context. Based on an extended model of relationship quality and by applying the social information processing perspective, this research tests the relevance of relationship quality for online relationships and explores differences of the relationship quality-loyalty link between online and offline retailers. To test the model, a large-scale study is conducted on both online and offline relationships for two service contexts (media and travel retailing). Using multi-group structural equation modeling, the authors identify differences between the online and offline environment in both service contexts. Results show that (1) relationship quality is similarly important for retaining customers online and offline and (2) differences in the impact of relationship-quality dimensions strongly depends on the service context. & 2009 Elsevier Ltd. All rights reserved.
Comparing the Effects of Aromatherapy With Rose Oils and Warm Foot Bath on Anxiety in the First Stage of Labor in Nulliparous Women

BACKGROUND
Anxiety is the most common emotional response in women during delivery, which can be accompanied with adverse effects on fetus and mother.


OBJECTIVES
This study was conducted to compare the effects of aromatherapy with rose oil and warm foot bath on anxiety in the active phase of labor in nulliparous women in Tehran, Iran.


PATIENTS AND METHODS
This clinical trial study was performed after obtaining informed written consent on 120 primigravida women randomly assigned into three groups. The experimental group 1 received a 10-minute inhalation and footbath with oil rose. The experimental group 2 received a 10-minute warm water footbath. Both interventions were applied at the onset of active and transitional phases. Control group, received routine care in labor. Anxiety was assessed using visual analogous scale (VASA) at onset of active and transitional phases before and after the intervention. Statistical comparison was performed using SPSS software version 16 and P < 0.05 was considered significant.


RESULTS
Anxiety scores in the intervention groups in active phase after intervention were significantly lower than the control group (P < 0.001). Anxiety scores before and after intervention in intervention groups in transitional phase was significantly lower than the control group (P < 0.001).


CONCLUSIONS
Using aromatherapy and footbath reduces anxiety in active phase in nulliparous women.
Development and validation of a short form of the Fugl-Meyer motor scale in patients with stroke.

BACKGROUND AND PURPOSE
The 50-item Fugl-Meyer motor scale (FM) is commonly used in outcome studies. However, the lengthy administration time of the FM keeps it from being widely accepted for routine clinical use. We aimed to develop a short form of the FM (the S-FM) with sound psychometric properties for stroke patients.


METHODS
The FM was administered to 279 patients. It was then simplified based on expert opinions and the results of Rasch analysis. The psychometric properties (including Rasch reliability, concurrent validity, predictive validity, and responsiveness) of the S-FM were examined and were compared with those of the FM. The concurrent validity and responsiveness of the S-FM were further validated in a sample from the Netherlands.


RESULTS
We selected 6 items for each subscale to construct a 12-item S-FM. The S-FM demonstrated high Rasch reliability, high concurrent validity with the original scale, moderate responsiveness, and moderate predictive validity with the comprehensive activities of daily living function. The S-FM also showed sufficient concurrent validity and responsiveness on the Dutch sample.


CONCLUSIONS
Our results provide strong evidence that the psychometric properties of the S-FM are comparable with those of the FM. The S-FM contains only 12 items, making it a very efficient measure for assessing the motor function of stroke patients in both clinical and research settings.
Chronic reduction of GIP secretion alleviates obesity and insulin resistance under high-fat diet conditions.

Gastric inhibitory polypeptide (GIP) exhibits potent insulinotropic effects on β-cells and anabolic effects on bone formation and fat accumulation. We explored the impact of reduced GIP levels in vivo on glucose homeostasis, bone formation, and fat accumulation in a novel GIP-GFP knock-in (KI) mouse. We generated GIP-GFP KI mice with a truncated prepro-GIP gene. The phenotype was assessed in heterozygous and homozygous states in mice on a control fat diet and a high-fat diet (HFD) in vivo and in vitro. Heterozygous GIP-GFP KI mice (GIP-reduced mice [GIP(gfp/+)]) exhibited reduced GIP secretion; in the homozygous state (GIP-lacking mice [GIP(gfp/gfp)]), GIP secretion was undetectable. When fed standard chow, GIP(gfp/+) and GIP(gfp/gfp) mice showed mild glucose intolerance with decreased insulin levels; bone volume was decreased in GIP(gfp/gfp) mice and preserved in GIP(gfp/+) mice. Under an HFD, glucose levels during an oral glucose tolerance test were similar in wild-type, GIP(gfp/+), and GIP(gfp/gfp) mice, while insulin secretion remained lower. GIP(gfp/+) and GIP(gfp/gfp) mice showed reduced obesity and reduced insulin resistance, accompanied by higher fat oxidation and energy expenditure. GIP-reduced mice demonstrate that partial reduction of GIP does not extensively alter glucose tolerance, but it alleviates obesity and lessens the degree of insulin resistance under HFD conditions, suggesting a potential therapeutic value.
Detection of Concrete Reinforcement Damage Using Piezoelectric Materials - Analytical and Experimental Study

An effort for the detection of damages in the reinforcement bars of reinforced concrete members using PZTs is presented. The damage can be the result of excessive elongation of the steel bar due to steel yielding or due to local steel corrosion. In both cases the damage is simulated by considering reduced diameter of the rebar along the damaged part of its length. An integration approach based on both electromechanical admittance methodology and guided wave propagation technique is used to evaluate the artificial damage on the examined longitudinal steel bar. Two actuator PZTs and a sensor PZT are considered to be bonded on the examined steel bar. The admittance of the Sensor PZT is calculated using COMSOL 3.4a. Fast Furrier Transformation for a better evaluation of the results is employed. An effort for the quantification of the damage detection using the root mean square deviation (RMSD) between the healthy condition and damage state of the sensor PZT is attempted. The numerical value of the RSMD yields a level for the difference between the healthy and the damaged admittance computation indicating this way the presence of damage in the structure. Experimental measurements are also presented. Keywords—Concrete reinforcement, damage detection, electromechanical admittance, experimental measurements, finite element method, guided waves, PZT.
ELECTROMAGNETIC DESIGN AND ANALYSIS OF A NOVEL MAGNETIC-GEAR-INTEGRATED WIND POWER GENERATOR USING TIME-STEPPING FINITE ELEMENT METHOD

This paper presents a novel permanent-magnet (PM) machine for wind power generation. In order to achieve high power/torque density as well as get rid of the nuisances aroused by the mechanical gearbox, a coaxial magnetic gear (CMG) is engaged. Different from the existing integrated machine in which armature windings are deployed in the inner bore of the CMG as an individual part, stator windings are directly inserted among the slots between the ferromagnetic segments in this proposed machine. Thus, it can offer several merits, such as simpler mechanical structure, better utilization of PM materials and lower manufacturing cost. Moreover, by artfully designing the connection of the armature windings, the electromagnetic coupling between the windings and the outer rotor PMs can be dramatically decreased, and the electromechanical energy conversion can be achieved by the field interaction between the inner rotor PMs and the armature windings. Received 16 December 2010, Accepted 1 February 2011, Scheduled 8 February 2011 Corresponding author: Linni Jian (ln.jian@siat.ac.cn).
Persistence of posttraumatic stress in violently injured youth seen in the emergency department.

OBJECTIVE
To determine if symptoms of posttraumatic stress, initially evaluated in the emergency department (ED) setting, persist over time.


DESIGN
Prospective cohort study.


SETTING
Two urban, academic medical center EDs.


PATIENTS
Sixty-nine injured patients, aged 12 to 24 years, were assessed for acute posttraumatic stress symptoms at the time of their enrollment in an ongoing ED-based study of intentional youth violence, and assessed for posttraumatic stress symptoms up to 5 months later.


MAIN OUTCOME MEASURES
The Immediate Stress Reaction Checklist, administered during the ED visit, and the Symptom Checklist of the Child and Adolescent Trauma Survey, administered during routine telephone follow-up.


RESULTS
Patients in the emergency department reported a range of acute stress symptoms on the Immediate Stress Reaction Checklist, with 25% reporting clinically significant distress. On follow-up assessment, 15% reported significant posttraumatic stress symptoms. The severity of acute stress symptoms was strongly associated with the severity of posttraumatic stress symptoms at follow-up (r = 0.55, P<.005). Age, sex, injury type, and time from injury to follow-up were not associated with the degree of acute stress or posttraumatic stress symptom severity at initial or follow-up assessment.


CONCLUSION
This study provides preliminary evidence that acute stress symptoms, assessed in the ED in the immediate aftermath of a traumatic injury, are useful indicators of risk for later posttraumatic stress.
Comparison between cold water immersion therapy (CWIT) and light emitting diode therapy (LEDT) in short-term skeletal muscle recovery after high-intensity exercise in athletes—preliminary results

In the last years, phototherapy has becoming a promising tool to improve skeletal muscle recovery after exercise, however, it was not compared with other modalities commonly used with this aim. In the present study we compared the short-term effects of cold water immersion therapy (CWIT) and light emitting diode therapy (LEDT) with placebo LEDT on biochemical markers related to skeletal muscle recovery after high-intensity exercise. A randomized double-blind placebo-controlled crossover trial was performed with six male young futsal athletes. They were treated with CWIT (5°C of temperature [SD ±1°]), active LEDT (69 LEDs with wavelengths 660/850 nm, 10/30 mW of output power, 30 s of irradiation time per point, and 41.7 J of total energy irradiated per point, total of ten points irradiated) or an identical placebo LEDT 5 min after each of three Wingate cycle tests. Pre-exercise, post-exercise, and post-treatment measurements were taken of blood lactate levels, creatine kinase (CK) activity, and C-reactive protein (CRP) levels. There were no significant differences in the work performed during the three Wingate tests (p > 0.05). All biochemical parameters increased from baseline values (p < 0.05) after the three exercise tests, but only active LEDT decreased blood lactate levels (p = 0.0065) and CK activity (p = 0.0044) significantly after treatment. There were no significant differences in CRP values after treatments. We concluded that treating the leg muscles with LEDT 5 min after the Wingate cycle test seemed to inhibit the expected post-exercise increase in blood lactate levels and CK activity. This suggests that LEDT has better potential than 5 min of CWIT for improving short-term post-exercise recovery.
Relational Grid Monitoring Architecture (R-GMA)

We describe R-GMA (Relational Grid Monitoring Architecture) which has been developed within the European DataGrid Project as a Grid Information and Monitoring System. Is is based on the GMA from GGF, which is a simple Consumer-Producer model. The special strength of this implementation comes from the power of the relational model. We offer a global view of the information as if each Virtual Organisation had one large relational database. We provide a number of different Producer types with different characteristics; for example some support streaming of information. We also provide combined Consumer/Producers, which are able to combine information and republish it. At the heart of the system is the mediator, which for any query is able to find and connect to the best Producers for the job. We have developed components to allow a measure of inter-working between MDS and R-GMA. We have used it both for information about the grid (primarily to find out about what services are available at any one time) and for application monitoring. R-GMA has been deployed in various testbeds; we describe some preliminary results and experiences of this deployment.
Gurevich Abstract State Machines and Schoenhage Storage Modification Machines.

We demonstrate that Schh onhage storage modiication machines are equivalent , in a strong sense, to unary abstract state machines. We also show t h a t i f one extends the Schh onhage model with a pairing function and removes the unary restriction , then equivalence between the two machine models survives.
Adopting agile practices when developing software for use in the medical domain

SUMMARY Non-safety critical software developers have been reaping the benefits of adopting agile practices for a number of years. However, developers of safety critical software often have concerns about adopting agile practices. Through performing a literature review, this research has identified the perceived barriers to following agile practices when developing medical device software. A questionnaire based survey was also conducted with medical device software developers in Ireland to determine the barriers to adopting agile practices. The survey revealed that half of the respondents develop software in accordance with a plan driven software development lifecycle and that they believe that there are a number of perceived barriers to adopting agile practices when developing regulatory compliant software such as: being contradictory to regulatory requirements; insufficient coverage of risk management activities and the lack of up-front planning. In addition, a comparison is performed between the perceived and actual barriers. Based upon the findings of the literature review and survey, it emerged that no external barriers exist to adopting agile practices when developing medical device software and the barriers that do exists are internal barriers such as getting stakeholder buy in.
Workplace determinants of endotoxin exposure in dental healthcare facilities in South Africa.

OBJECTIVES
Aerosols generated during dental procedures have been reported to contain endotoxin as a result of bacterial contamination of dental unit water lines. This study investigated the determinants of airborne endotoxin exposure in dental healthcare settings.


METHODS
The study population included dental personnel (n = 454) from five academic dental institutions in South Africa. Personal air samples (n = 413) in various dental jobs and water samples (n = 403) from dental handpieces and basin taps were collected. The chromogenic-1000 limulus amebocyte lysate assay was used to determine endotoxin levels. Exposure metrics were developed on the basis of individually measured exposures and average levels within each job category. Analysis of variance and multivariate linear regression models were constructed to ascertain the determinants of exposure in the dental group.


RESULTS
There was a 2-fold variation in personal airborne endotoxin from the least exposed (administration) to the most exposed (laboratory) jobs (geometric mean levels: 2.38 versus 5.63 EU m(-3)). Three percent of personal samples were above DECOS recommended exposure limit (50 EU m(-3)). In the univariate linear models, the age of the dental units explained the most variability observed in the personal air samples (R(2) = 0.20, P < 0.001), followed by the season of the year (R(2) = 0.11, P < 0.001). Other variables such as institution and total number of dental units per institution also explained a modest degree of variability. A multivariate model explaining the greatest variability (adjusted R(2) = 0.40, P < 0.001) included: the age of institution buildings, total number of dental units per institution, ambient temperature, ambient air velocity, endotoxin levels in water, job category (staff versus students), dental unit model type and age of dental unit.


CONCLUSIONS
Apart from job type, dental unit characteristics are important predictors of airborne endotoxin levels in this setting.
How computer games affect CS (and other) students' school performance

Compulsive game playing, especially of the role-playing variety, risks failing grades and withdrawal of financial support from tuition-paying parents.
Effect of aripiprazole on cognition in the treatment of patients with schizophrenia.

BACKGROUND
The aim of this study was to assess the cognitive effects of aripiprazole in inpatients with schizophrenia.


METHODS
This was an investigator-initiated, open label eight-week trial evaluating 56 inpatients with the DSM-IV diagnosis of schizophrenia. Efficacy was assessed weekly using the Positive and Negative Syndrome Scale (PANSS) and tolerability was assessed each week using the Udvalg for Klinske Undersogelser side effect rating scale (UKU). Cognitive function was assessed at baseline, week 4 and week 8.


RESULTS
Aripiprazole showed significant improvement in PANSS total score and all subscores between baseline and endpoint visit. The substance was very well tolerated. Patients improved significantly in verbal memory, reaction time and reaction quality/attention from baseline to week eight. Furthermore, mean z-values of individual cognitive domains summarized in a global cognitive index improved significantly from baseline to week eight.


DISCUSSION
Our results suggest that aripiprazole provides a valuable treatment option for patients with schizophrenia.