LLukas22/scidocs huggingface dataset:
Comparison between automatic tube compensation and continuous positive airway pressure during spontaneous breathing trials.

BACKGROUND
Various methods to perform spontaneous breathing trials (SBTs) exist, but no one method has been shown to be superior. Automatic tube compensation (ATC) is a new and potentially advantageous ventilation mode to use during SBT. We compared ATC to continuous positive airway pressure (CPAP) during SBTs, to determine their efficacy in identifying patients ready to be liberated from mechanical ventilation.


METHODS
We randomized 118 adults in a general intensive care unit on mechanical ventilation for > or = 24 h who were about to undergo an SBT as part of an established respiratory-therapist-driven weaning protocol to undergo 30 min SBT with ATC or CPAP with no pressure support. We predefined the SBT-failure criteria. The primary outcome was duration of weaning (days from first SBT to extubation). Other outcomes included unsuccessful extubation within 48 h, first-SBT-pass rate, and total duration of mechanical ventilation.


RESULTS
We found a trend toward less failure of first SBT with ATC, compared to CPAP (3% vs 13% respectively, P = .09), but no difference in duration of weaning, rate of unsuccessful extubation, or duration of mechanical ventilation.


CONCLUSIONS
When applied as part of a respiratory-therapist-driven weaning protocol in a general intensive-care population, SBTs with ATC were safe but did not hasten liberation from mechanical ventilation, when compared to CPAP.
A genome-wide association study in catfish reveals the presence of functional hubs of related genes within QTLs for columnaris disease resistance

Columnaris causes severe mortalities among many different wild and cultured freshwater fish species, but understanding of host resistance is lacking. Catfish, the primary aquaculture species in the United States, serves as a great model for the analysis of host resistance against columnaris disease. Channel catfish in general is highly resistant to the disease while blue catfish is highly susceptible. F2 generation of hybrids can be produced where phenotypes and genotypes are segregating, providing a useful system for QTL analysis. To identify genes associated with columnaris resistance, we performed a genome-wide association study (GWAS) using the catfish 250 K SNP array with 340 backcross progenies derived from crossing female channel catfish (Ictalurus punctatus) with male F1 hybrid catfish (female channel catfish I. punctatus × male blue catfish I. furcatus). A genomic region on linkage group 7 was found to be significantly associated with columnaris resistance. Within this region, five have known functions in immunity, including pik3r3b, cyld-like, adcyap1r1, adcyap1r1-like, and mast2. In addition, 3 additional suggestively associated QTL regions were identified on linkage groups 7, 12, and 14. The resistant genotypes on the QTLs of linkage groups 7 and 12 were found to be homozygous with both alleles being derived from channel catfish. The paralogs of the candidate genes in the suggestively associated QTL of linkage group 12 were found on the QTLs of linkage group 7. Many candidate genes on the four associated regions are involved in PI3K pathway that is known to be required by many bacteria for efficient entry into the host. The GWAS revealed four QTLs associated with columnaris resistance in catfish. Strikingly, the candidate genes may be arranged as functional hubs; the candidate genes within the associated QTLs on linkage groups 7 and 12 are not only co-localized, but also functionally related, with many of them being involved in the PI3K signal transduction pathway, suggesting its importance for columnaris resistance.
A Ka-band waveguide-based traveling-wave spatial power divider/combiner

A Ka-band waveguide-based four-stage eight-way power divider/combiner is presented based on the traveling-wave technique and the spatial power combining technique. The dualprobe, which are symmetrically inserted in one broadside of the waveguide, double the power dividing ways without adding the insertion loss. The method of images is used to simplify the analysis and design process of the dual-probe structure. The power divider/combiner is designed, fabricated and measured to demonstrate its wide bandwidth and low insertion loss performance. From 30GHz to 40GHz, the measured return loss of the back-to-back structure is lower than -15dB and the insertion loss is less than 1.2dB.
Current trend and risk factors for kidney stones in persons with spinal cord injury: a longitudinal study

Study design: A multi-center longitudinal study.Objectives: To estimate the current trend in the incidence of first kidney stone among persons with spinal cord injury (SCI) and to delineate the potential contributing factors.Setting: Twenty-one Model SCI Care Systems throughout the United States.Methods: A longitudinal cohort of 8314 subjects enrolled in the National SCI Database between 1986 and 1999 was used to estimate and compare the incidence of first kidney stone with a previous report of 5850 SCI patients injured between 1973 and 1982. A Cox regression analysis was performed to identify risk factors for stones, including age, race, gender, severity of injury, and method of urinary drainage. These variables have been routinely collected, on a yearly basis, by the collaborating SCI centers.Results: During the 12 years, 6 months of case ascertainment, 286 incident stone cases were documented. The risk was greatest during the first 3 months after injury (31 cases per 1000 person-years), quickly decreasing and leveling off later (eight cases per 1000 person-years). It was estimated that within 10 years after injury, 7% of persons with SCI would develop their first kidney stone. There was no evidence that the risk has changed over the past 25 years (P=0.96). During the first year post injury only, a significantly increased risk of stones was observed in Caucasians and persons aged 45 years or older. A positive association of the severity of injury and requiring instrumentation for bladder emptying with kidney stones was found after the first year post injury. The type of urinary drainage, including indwelling, intermittent, and condom catheterization, had no significant differential effect on stone formation at either risk period.Conclusions: The highest risk of kidney stones is within the first few months post injury. Little progress has been made in reducing this risk. Although inability to control bladder function is an important risk factor after the first year post injury, for those who need bladder management, the type of urinary drainage does not appear to be an important factor in determining risk.
Ubiquity symposium: Evolutionary computation and the processes of life: evolutionary computation and evolutionary game theory: expecting the unexpected

In this article, David Fogel discusses the relationship between evolutionary computation and evolutionary game theory. The mathematics of evolutionary game theory relies on assumptions that often fail to describe the real-world conditions that the theory is intended to model. This article highlights those assumptions and suggests evolutionary computation may ultimately serve as a more useful approach to understanding complex adaptive systems in nature.
Building Information Modeling in Architecture, Engineering, and Construction: Emerging Research Directions and Trends

Currently, the architecture, engineering, and construction industry is facing enormous technological and institutional changes and challenges including the proliferation of information technology and appropriate application of sustainable practices. The 21st century engineer and architect must be able to deal with a rapid pace of technological change, a highly interconnected world, and complex problems that require multidisciplinary solutions. This paper focuses on research directions and trends around building information modeling BIM through interdisciplinary endeavors: how BIM research topics could be explored; their relevancy; and their potential future impact. It identifies BIM research topics that are considered to be important to a wide range of practitioners and future practitioners, both architecture and engineering students. It also assesses the relevance of current research projects to the industry and categorizes future BIM research topics. It aims to formulate research ideas and methodologies to pursue them and to explore how an industry/academic partnership for exploring exciting research opportunities could be established. DOI: 10.1061/ ASCE EI.1943-5541.0000023 CE Database subject headings: Sustainable development; Construction industry; Research; Information technology; Buildings. Author keywords: Building information modeling; Sustainable development; Construction industry; Research; Information technology; Virtual design and construction.
Detail preserving continuum simulation of straight hair

Hair simulation remains one of the most challenging aspects of creating virtual characters. Most research focuses on handling the massive geometric complexity of hundreds of thousands of interacting hairs. This is accomplished either by using brute force simulation or by reducing degrees of freedom with guide hairs. This paper presents a hybrid Eulerian/Lagrangian approach to handling both self and body collisions with hair efficiently while still maintaining detail. Bulk interactions and hair volume preservation is handled efficiently and effectively with a FLIP based fluid solver while intricate hair-hair interaction is handled with Lagrangian self-collisions. Thus the method has the efficiency of continuum/guide based hair models with the high detail of Lagrangian self-collision approaches.
Bifurcations of Unimodal Maps

We review recent results that lead to a very precise understanding of the dynamics of typical unimodal maps from the statistical point of view. We also describe the (generalized) renormalization approach to the study of the statistical properties of typical unimodal maps.
Industry 4.0 and the futur revolution for human-centered industry

The development of new technologies namely in the microelectronic and the communication domains drives a new industrial revolution. As every revolution, industry 4.0 will change our way of working and bring new opportunities and challenges. This paper presents the new technologies and human-centred applications related to industry 4.0. and concludes on what it will bring to humans and societies. Keywords-Human-centered industrial technology; additive manufacturing; Augmented reality; industry 4.0; Robotic.
Towards a Multi-camera Generalization of Brightness Constancy

Standard optical flow methods for motion or disparity estimation use a brightness constancy constraint equation (BCCE). This BCCE either handles a moving camera imaging a non-moving scene or a fixed camera imaging a moving scene. In this paper a BCCE is developed that can handle instantaneous motion of the camera on a 2D plane normal to the viewing direction and motion of the imaged scene. From the thus acquired up to 5 dimensional data set 3D object motion, 3D surface element position, and -normals can be estimated simultaneously. Experiments using 1d or 2d camera grids and a weighted total least squares (TLS) estimation scheme demonstrate performance in terms of systematic error and noise stability, and show technical implications.
Peer-led education for adolescents with asthma in Jordan: a cluster-randomized controlled trial.

OBJECTIVES
To determine the impact of a peer-led education program, developed in Australia, on health-related outcomes in high school students with asthma in Jordan.


METHODS
In this cluster-randomized controlled trial, 4 high schools in Irbid, Jordan, were randomly assigned to receive the Adolescent Asthma Action program or standard practice. Bilingual health workers trained 24 peer leaders from Year 11 to deliver asthma education to younger peers from Year 10 (n = 92), who in turn presented brief asthma skits to students in Years 8 and 9 (n = 148) and to other members of the school community in the intervention schools. Students with asthma (N = 261) in Years 8, 9, and 10 completed baseline surveys in December 2006 and 3 months after the intervention.


RESULTS
Students from the intervention group reported clinically significant improvements in health-related quality of life (mean difference: 1.35 [95% confidence interval: 1.04-1.76]), self-efficacy to resist smoking (mean difference: 4.63 [95% confidence interval: 2.93-6.35]), and knowledge of asthma self- management (mean difference: 1.62 [95% confidence interval: 1.15-2.19]) compared with the control group.


CONCLUSIONS
This trial demonstrated that the Adolescent Asthma Action program can be readily adapted to suit different cultures and contexts. Adolescents in Jordan were successful in teaching their peers about asthma self-management and motivating them to avoid smoking. The findings revealed that peer education can be a useful strategy for health promotion programs in Jordanian schools when students are given the opportunity and training.
Cardiovascular effects of longer-term, high-dose OROS methylphenidate in adolescents with attention deficit hyperactivity disorder.

OBJECTIVE
To examine the effects of high doses of extended-release methylphenidate (OROS MPH) on cardiovascular variables in adolescents with attention deficit hyperactivity disorder (ADHD).


STUDY DESIGN
ECG indices plus systolic blood pressure (SBP), diastolic BP (DBP) and heart rate (HR) were assessed during an open-label study of OROS MPH in 114 adolescents with ADHD (doses up to 1.5 mg/kg/d). Cardiovascular parameters were assessed at 6 weeks and 6 months.


RESULTS
Small but statistically significant changes in DBP and HR were observed at 6 weeks, without further increases up to 6 months' follow-up. A small but statistically significant increase in SBP was observed over time. Twenty-nine percent of patients had isolated elevations in BP readings prior to study entry, and 14% had >3 consecutive visits at which elevated BP were observed during OROS MPH treatment. No clinically significant changes in ECG parameters were observed. No serious cardiovascular adverse events occurred.


CONCLUSIONS
Treatment with relatively high doses of OROS MPH was associated with small but statistically significant mean increases in BP and HR, primarily during the first 6 weeks of treatment, without clinically meaningful changes in ECG. These observations are consistent with previous reports using lower doses.
How Deaf Children Learn: What Parents and Teachers Need to Know /

1. What It's All About Who Are We and What Are We Doing Here? Alternative Perspectives on Educating Deaf Students Using This Book Notes, Confessions, and Acknowledgments 2. Introduction to Deaf Children Navigating Issues Those Who Ignore History... Terms of Endearment (or Not) Differences versus Deficiencies Final Words 3. On Hearing and Not Hearing Understanding Hearing Hearing Aids Everything You Always Wanted to Know About Cochlear Implants Final Words 4. Language and Communication Understanding Language From Communication to Language Signed Languages and Visual Communication Systems Spoken Communication Final Words 5. Family and Peers: Foundations of Learning Education Begins at Home Social Interactions: Foundations for Learning Early Intervention Moving from Home to School Social-Emotional Growth during the School Years Last Words 6. Deaf Cognition Are Deaf Children As Smart As Hearing Children? Do Deaf Individuals See Better? Does Sign Language Have an Effect on Words about 7. Learning and Memory Cognition and Learning: From Darkness to Enlightenment Learning Memory Final Words 8. Problem Solving and Knowledge Experience and Conceptual Development Integration and Organization of Knowledge Final Words 9. Reading The Challenge of Learning to Read What Can We Do about Deaf Students' Reading Achievement? A Few Words about Writing Final Words 10. Doing Math: Foundations Understanding Number Understanding Mathematics during the School Years Improving Mathematics Performance by Deaf Children Final Words 11. The Deaf Education Classroom Options in Deaf Education Programming Assessment and Classroom Placement Classroom Diversity The Classroom Deaf Education Professionals Final Words 12. Where Do We Go from Here? A Journey of 1000 Miles Begins with a Single Step The More Things Change the More They Stay the Same There Are Differences and Then There Are Differences What We Know and What We Need to Know Final Final Words Additional Reading References Index
Caries risk reduction in patients attending a caries management clinic.

BACKGROUND
A Caries Management Clinic was established for patients at high risk of caries aiming to reduce caries incidence to close to zero. That is, to prevent new lesions on existing sound surfaces, along the susceptible restoration margins, and to remineralize existing cavitated and non-cavitated lesions. Twenty patients attended the clinic every two weeks from April to December 2005.


METHODS
The Caries Management System is a ten-step non-invasive strategy to arrest and remineralize early lesions and includes consideration of the patient at risk, the status of each individual lesion, patient management, clinical management, and monitoring.


RESULTS
After six months, there was a 42 per cent increase in gingival sites having Gingival Index scores of zero, and a 21 per cent decrease in sites having Gingival Index scores of 2 compared to baseline (chi(2 )=( )137.67, 4 df, p = 0.00001). Ready to change (RTC) patients had significantly fewer sites scored GI <or= 2 compared to not-RTC patients (p = 0.01). Compared with the not-RTC patients, RTC patients were more than twice as likely to have fewer sites scored GI </= 2 (RR = 2.43, 95% CI (1.24, 4.71), p = 0.01). A total of 100 out of 146 smooth non-cavitated carious surfaces at baseline have remineralized after six months, 99 per cent of sound surfaces remained sound, and 23 new lesions were observed in six of the 20 patients (alpha(2 )=( )292, 7 df, p = 0.00001). About half of proximal surfaces showing bitewing scores of grade 1 or 2 had regressed (alpha(2 )=( )86.66, 56 df, p = 0.0001) and 95 per cent of proximal sound surfaces at baseline, as diagnosed via bitewing radiographs, remained sound.


CONCLUSIONS
This audit revealed that the implementation of the non-invasive approach to caries management which combined intensive coaching in oral hygiene maintenance, special home care and intensive monitoring in a clinic for high-risk patients was able to reduce gingival inflammation and maintain low plaque levels, at least within the scope of this short-term review.
Adam Smith Goes Mobile : Managing Services Beyond 3 G with the Digital Marketplace

The next generation of mobile communications systems is expected to offer new business opportunities to existing and new market players. A market-based middleware framework has been recently proposed whereby service providers, independent of network operators, are able to tender online service contracts to network operators in a dynamic and competitive manner. This facilitates a seamless service provision over disparate networks in a consumer-centric manner. Service providers select network bearers according to the network operators' ability to meet the QoS target, which in turn is influenced, among other things, by user's price and quality requirements. The benefits of this proposal are the complementarity of numerous network resources, the decoupling of services and networks in a self-organising distributed environment, and increased competition to consumers’ advantage.
Early lapses in a cessation attempt: lapse contexts, cessation success, and predictors of early lapse.

INTRODUCTION
The great majority of smokers relapse when they make quit attempts. Therefore, understanding the process of relapse may guide the development of more effective smoking cessation or relapse prevention treatments. The goal of this research is to extend our understanding of the context of initial lapses that occur within 8 weeks of quitting by using more comprehensive assessments of context, a contemporary sample, and sophisticated analytic techniques.


METHODS
Participants from a randomized controlled smoking cessation trial completed baseline assessments of demographics and tobacco dependence, a daily smoking calendar to determine latency to lapse and relapse (7 consecutive days of smoking), and an assessment of initial lapse context (affect, location, activity, interpersonal, smoke exposure, and cigarette availability). Latent class analysis (LCA) was used to analyze the 6 early lapse (within the first 8 weeks; N = 551) context dimensions; logistic regression and Cox regression were used to relate context to cessation outcomes.


RESULTS
LCA revealed 5 distinct initial lapse context classes (talking, with friends, angry; social; alone; with spouse, angry; and with smoking spouse) that were differentially related to cessation outcome. The easy availability of cigarettes characterized almost 75% of lapses, but being with friends, drinking, and not being at home were associated with a lower likelihood of progression to relapse.


CONCLUSIONS
Early lapsing is highly related to ultimate relapse, and lapsing in frequently experienced contexts seemed most strongly linked with progression to full relapse.
Eucken's ‘Social Market Economy’ and Its Test in Post‐War West Germany

Abstract. Walter Eucken's paradigm of a “social market economy” and “Ordnung” provides a framework for a functional free‐market mechanism, which not only accommodates development and change, but which also assures human dignity and freedom, as cornerstones of the Kantian moral universe. Eucken places special emphasis on the integration of economics with “order” and “Justice,” in a synthesis of negative liberty and positive freedom and of Rawls' and Nozick's theories of justice. Adam Smith's laissez faire economy does not assure a competitive economy, he holds, and will evolve into monopolistic practices, interventionism, and distortions of price relationships; but “structural” and “regulating” principles will facilitate a functionally competitive economy with a compatible social policy, characterized by a flexible price mechanism and stable policies. This “social market economy” would provide goods and services efficiently and also eliminate poverty and the maldistribution of income and resources.
Inflammatory basis of exercise-induced bronchoconstriction.

RATIONALE
Exercise-induced bronchoconstriction (EIB) is a highly prevalent condition with unclear pathogenesis. Two competing theories of the pathogenesis of EIB differ regarding the inflammatory basis of this condition.


OBJECTIVES
Our goals were to establish whether epithelial cell and mast cell activation with release of inflammatory mediators occurs during EIB and how histamine and cysteinyl leukotriene antagonists alter the airway events occurring during EIB.


METHODS
Induced sputum was used to measure mast cell mediators and eicosanoids at baseline and 30 minutes after exercise challenge in 25 individuals with asthma with EIB. In a randomized, double-blind crossover study, the cysteinyl leukotriene antagonist montelukast and antihistamine loratadine or two matched placebos were administered for two doses before exercise challenge.


MAIN RESULTS
The percentage of columnar epithelial cells in induced sputum at baseline was associated with the severity of EIB. After exercise challenge, histamine, tryptase, and cysteinyl leukotrienes significantly increased and prostaglandin E(2) and thromboxane B(2) significantly decreased in the airways, and there was an increase in columnar epithelial cells in the airways. The concentration of columnar epithelial cells was associated with the levels of histamine and cysteinyl leukotrienes in the airways. Treatment with montelukast and loratadine inhibited the release of cysteinyl leukotrienes and histamine into the airways, but did not inhibit the release of columnar epithelial cells into the airways.


CONCLUSIONS
These data indicate that epithelial cells, mast cell mediators, and eicosanoids are released into the airways during EIB, supporting an inflammatory basis for EIB.