LLukas22/scidocs huggingface dataset:
Early experience of pediatric thoracoscopic lobectomy in the UK.

PURPOSE
The aim of this study was to report on the early experience of pediatric thoracoscopic lobectomy in two UK centers (Royal Hospital for Sick Children, Edinburgh, and Addenbrookes Hospital, Cambridge).


METHODS
Twelve patients between February 2000 and November 2005 were treated with a lobectomy for pulmonary disease.


RESULTS
Diagnoses included 7 congenital cystic adenomatous malformations, 4 patients with bronchiectasis, and 1 thoracic mature teratoma. The patients' ages ranged from 8 months to 15 years. In all patients, a thoracoscopic lobectomy was attempted. In all cases, the lobectomy was completed; however, in 6 patients, the conversion to either video-assisted thoracoscopic surgery (VATS) or open thoracotomy was required. Of note, 9 of the 12 patients had had previous lung infections prior to lobectomy. Five of 6 that required a conversion to VATS or open thoracotomy had had significant previous pulmonary infection, causing hilar lymphadenopathy and adhesions that complicated the dissection. The other case requiring a conversion to thoracotomy had abnormal hilar anatomy with an incomplete oblique fissure.


CONCLUSIONS
Patients with a previous history of pulmonary infection can cause difficulty in dissection of the hilum that can necessitate a conversion to VATS or open thoracotomy. An infection prior to lobectomy can cause difficulty in completing the procedure safely thoracoscopically. Consideration of patients with pulmonary disease for lobectomy should be made prior to the onset of infectious complications. The thoracoscopic lobectomy can still be performed in patients with a preceding history of infectious complications, though a higher rate of conversion is likely.
Treatment of the immature tooth with a non-vital pulp and apical periodontitis.

Traditional methods of treatment of immature root with necrotic pulp and apical periodontitis pose multiple challenges. These challenges include disinfection of the root canal with standard protocols that aggressively use endodontic files, filling the root canal with an open apex that provides no barrier for stopping the root filling material before impinging on the periodontal tissues, and the susceptibility of the teeth to fracture because of their thin roots. Disinfection using sodium hypochlorite, apical barrier formation using calcium hydroxide as well as mineral trioxide aggregate, and pulp revascularization of fractured tooth with the help of blood clot and collagen-enhanced matrix has been discussed in detail in this article.
A Program Plagiarism Detection Model Based on Information Distance and Clustering

Plagiarism in students programming assignment submissions causes considerable difficulties for course designers. Efficient detection of plagiarism in programming assignments of students is important to the educational procedure. This paper proposes a metric, based on information distance, to measure similarity between two programs. Furthermore, clustering analysis, based on shared near neighbors, is applied in order to provide more beneficial and detailed information about the program plagiarism. Experimental results demonstrate that our software has clear advantages over other plagiarism detection systems and it is quite beneficial to teachers to get rid of time-consuming and toilsome tasks. Key words: Program plagiarism, Detection, Information distance, Clustering
Baricitinib in patients with inadequate response or intolerance to conventional synthetic DMARDs: results from the RA-BUILD study

BACKGROUND
Baricitinib is an oral, reversible, selective Janus kinase 1 and 2 inhibitor.


METHODS
In this phase III, double-blind 24-week study, 684 biologic disease-modifying antirheumatic drug (DMARD)-naïve patients with rheumatoid arthritis and inadequate response or intolerance to ≥1 conventional synthetic DMARDs were randomly assigned 1:1:1 to placebo or baricitinib (2 or 4 mg) once daily, stratified by region and the presence of joint erosions. Endpoint measures included American College of Rheumatology 20% response (ACR20, primary endpoint), Disease Activity Score (DAS28) and Simplified Disease Activity Index (SDAI) score ≤3.3.


RESULTS
More patients achieved ACR20 response at week 12 with baricitinib 4 mg than with placebo (62% vs 39%, p≤0.001). Compared with placebo, statistically significant improvements in DAS28, SDAI remission, Health Assessment Questionnaire-Disability Index, morning joint stiffness, worst joint pain and worst tiredness were observed. In a supportive analysis, radiographic progression of structural joint damage at week 24 was reduced with baricitinib versus placebo. Rates of adverse events during the treatment period and serious adverse events (SAEs), including serious infections, were similar among groups (SAEs: 5% for baricitinib 4 mg and placebo). One patient had an adverse event of tuberculosis (baricitinib 4 mg); one patient had an adverse event of non-melanoma skin cancer (baricitinib 4 mg). Two deaths and three major adverse cardiovascular events occurred (placebo). Baricitinib was associated with a decrease in neutrophils and increases in low-density and high-density lipoprotein.


CONCLUSIONS
In patients with rheumatoid arthritis and an inadequate response or intolerance to conventional synthetic DMARDs, baricitinib was associated with clinical improvement and inhibition of progression of radiographic joint damage.


TRIAL REGISTRATION NUMBER
NCT01721057; Results.
Comparison of ICD-10 and Gillberg’s Criteria for Asperger Syndrome:

In this study, algorithms designed for the Diagnostic Interview for Social and Communication Disorders (DISCO) were used to compare the ICD-10 criteria for Asperger syndrome with those suggested by Gillberg. Two hundred children and adults were studied, all of whom met the ICD-10 criteria for childhood autism or atypical autism. Only three (1 percent) met criteria for ICD-10 Asperger syndrome. In contrast, 91 (45 percent) met criteria for Asperger syndrome defined by Gillberg, which more closely resemble Asperger’s own descriptions. Results showed that the discrepancy in diagnosis was due to the ICD-10 requirement for ‘normal’ development of cognitive skills, language, curiosity and self-help skills. When comparisons were based on Gillberg’s criteria only, results showed the participants diagnosed as having Asperger syndrome differed significantly from the rest on all but two of Gillberg’s criteria. However, all of these criteria could be found in some of those not diagnosed as having Asperger syndrome. The results emphasize the differences between the two diagnostic systems. They also question the value of defining a separate subgroup and suggest that a dimensional view of the autistic spectrum is more appropriate than a categorical approach. address Correspondence should be addressed to: susan leekam , Department of Psychology,University of Durham,Science Laboratories,South Road,Durham DH1 3LE,UK keywords Asperger syndrome; autistic spectrum; diagnostic algorithm; Diagnostic Interview for Social and Communication Disorders (DISCO); Gillberg’s criteria; ICD-10 criteria
Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: results of the German CAO/ARO/AIO-94 randomized phase III trial after a median follow-up of 11 years.

PURPOSE
Preoperative chemoradiotherapy (CRT) has been established as standard treatment for locally advanced rectal cancer after first results of the CAO/ARO/AIO-94 [Working Group of Surgical Oncology/Working Group of Radiation Oncology/Working Group of Medical Oncology of the Germany Cancer Society] trial, published in 2004, showed an improved local control rate. However, after a median follow-up of 46 months, no survival benefit could be shown. Here, we report long-term results with a median follow-up of 134 months.


PATIENTS AND METHODS
A total of 823 patients with stage II to III rectal cancer were randomly assigned to preoperative CRT with fluorouracil (FU), total mesorectal excision surgery, and adjuvant FU chemotherapy, or the same schedule of CRT used postoperatively. The study was designed to have 80% power to detect a difference of 10% in 5-year overall survival as the primary end point. Secondary end points included the cumulative incidence of local and distant relapses and disease-free survival.


RESULTS
Of 799 eligible patients, 404 were randomly assigned to preoperative and 395 to postoperative CRT. According to intention-to-treat analysis, overall survival at 10 years was 59.6% in the preoperative arm and 59.9% in the postoperative arm (P = .85). The 10-year cumulative incidence of local relapse was 7.1% and 10.1% in the pre- and postoperative arms, respectively (P = .048). No significant differences were detected for 10-year cumulative incidence of distant metastases (29.8% and 29.6%; P = .9) and disease-free survival.


CONCLUSION
There is a persisting significant improvement of pre- versus postoperative CRT on local control; however, there was no effect on overall survival. Integrating more effective systemic treatment into the multimodal therapy has been adopted in the CAO/ARO/AIO-04 trial to possibly reduce distant metastases and improve survival.
Postural stability in patients with osteoarthritis of the hip. Pilot study.

BACKGROUND
Total hip arthroplasty involves division of the joint capsule, which can cause receptor damage, affecting postural stability and increasing the risk of falls. The aim of this study was to determine whether postural stability can be disturbed by total hip arthroplasty from a postero-lateral approach.


MATERIAL AND METHODS
Static balance was quantified with the use of a two plate tensometric platform in a study group of 16 patients (8 women and 8 men) with unilateral hip osteoarthritis, mean age 57.13 (± 10.7) years, height of 173.38 (± 9) cm, weight 90.21 (± 16.9) and BMI of 30.07 (± 2.87) kg/m2.


RESULTS
Postural balance improved after surgery, with a statistically significant decrease in the length of the sway path in the AP plane and a strong trend towards significance in the medio- lateral plane. The maximum deflection of the COP from the 0 in the Y direction was reduced. The average velocity of movement of the COP along the Y-axis was significantly reduced, and velocity along the X-axis in mm/s was reduced with a strong trend towards significance.


CONCLUSIONS
1. THA from a postero-lateral approach did not lead to a deterioration of postural stability in the early postoperative period. 2. Balance parameters, including path length and the average velocity of the COP in the antero-posterior plane, improved in a statistically significant manner. 3. The maximum extension of the COP in the frontal plane decreased with a strong trend towards significance.
Proteomic Analyses Reveal High Expression of Decorin and Endoplasmin (HSP90B1) Are Associated with Breast Cancer Metastasis and Decreased Survival

BACKGROUND
Breast cancer is the most common malignancy among women worldwide in terms of incidence and mortality. About 10% of North American women will be diagnosed with breast cancer during their lifetime and 20% of those will die of the disease. Breast cancer is a heterogeneous disease and biomarkers able to correctly classify patients into prognostic groups are needed to better tailor treatment options and improve outcomes. One powerful method used for biomarker discovery is sample screening with mass spectrometry, as it allows direct comparison of protein expression between normal and pathological states. The purpose of this study was to use a systematic and objective method to identify biomarkers with possible prognostic value in breast cancer patients, particularly in identifying cases most likely to have lymph node metastasis and to validate their prognostic ability using breast cancer tissue microarrays.


METHODS AND FINDINGS
Differential proteomic analyses were employed to identify candidate biomarkers in primary breast cancer patients. These analyses identified decorin (DCN) and endoplasmin (HSP90B1) which play important roles regulating the tumour microenvironment and in pathways related to tumorigenesis. This study indicates that high expression of Decorin is associated with lymph node metastasis (p<0.001), higher number of positive lymph nodes (p<0.0001) and worse overall survival (p = 0.01). High expression of HSP90B1 is associated with distant metastasis (p<0.0001) and decreased overall survival (p<0.0001) these patients also appear to benefit significantly from hormonal treatment.


CONCLUSIONS
Using quantitative proteomic profiling of primary breast cancers, two new promising prognostic and predictive markers were found to identify patients with worse survival. In addition HSP90B1 appears to identify a group of patients with distant metastasis with otherwise good prognostic features.
Impacts of changes in water quality on recreation behavior and benefits in Finland.

The implementation of the European Union Water Framework Directive (WFD) requires nationally generalizable estimates of the benefits of protecting inland and coastal waters. As an alternative to benefit transfers and meta-analyses, we utilize national recreation inventory data combined with water quality data to model recreation participation and estimate the benefits of water quality improvements. Using hurdle models, we analyze the association of water clarity in individuals' home municipalities with the three most common water recreation activities--swimming, fishing and boating. The results show no effect on boating, but improved water clarity would increase the frequency of close-to-home swimming and fishing, as well as the number of fishers. Furthermore, to value the potential benefits of the WFD, we estimate the consumer surplus of a water recreation day using a travel cost approach. A water policy scenario with a 1-m improvement in water clarity for both inland and coastal waters indicates that the consumer surplus would increase 6% for swimmers and 15% for fishers. In contrast to previously estimated abatement costs to improve water quality, net benefits could turn out to be positive. Our study is a promising example of applying existing national recreation inventory data to estimate the benefits of water quality improvements for the purposes of the WFD.
Risk evaluation approaches in failure mode and effects analysis: A literature review

0957-4174/$ see front matter 2012 Elsevier Ltd. A http://dx.doi.org/10.1016/j.eswa.2012.08.010 ⇑ Corresponding author. Address: College of De University, 1239 Siping Road, Shanghai 200092, PR 6598 3432. E-mail addresses: huchenliu@foxmaill.com (H.-C (L. Liu), liunan@cqjtu.edu.cn (N. Liu). Failure mode and effects analysis (FMEA) is a risk assessment tool that mitigates potential failures in systems, processes, designs or services and has been used in a wide range of industries. The conventional risk priority number (RPN) method has been criticized to have many deficiencies and various risk priority models have been proposed in the literature to enhance the performance of FMEA. However, there has been no literature review on this topic. In this study, we reviewed 75 FMEA papers published between 1992 and 2012 in the international journals and categorized them according to the approaches used to overcome the limitations of the conventional RPN method. The intention of this review is to address the following three questions: (i) Which shortcomings attract the most attention? (ii) Which approaches are the most popular? (iii) Is there any inadequacy of the approaches? The answers to these questions will give an indication of current trends in research and the best direction for future research in order to further address the known deficiencies associated with the traditional FMEA. 2012 Elsevier Ltd. All rights reserved.
Devanagari Character Recognition Using Gradient Features

We describe novel methods of feature extraction for recognition of single isolated Devanagari character images. Our approach is flexible in that the same algorithms can be used, without modification, for feature extraction in a variety of OCR problems. These include handwritten, machine-print, grayscale, and binary and low-resolution character recognition. We use the gradient representation as the basis for extraction of features. These algorithms require a few simple arithmetic operations per image pixel which ma kes them suitable for real-time applications. Our dataset consists of 200 samples of each of 36 basic Devanagari characters, which are collected from 20 different writers each contributing to write 10 samples of each of 36 characters. Thus we have used total 7200 character samples. All sample images of Devanagari characters used are normalized to 90*90 pixel sizes. A description of the algorithm and experiment with our data set is presented in this paper. Experimental results using Support Vector Machines (SVM) are presented. Our results demonstrate high performance of these features with cross validation accuracy of 94%. Keywords—Isolated Handwritten Devanagari Character Recognition, Gradient Features, Gradient Feature Extraction, SVM Classifier.
ECG data classification with deep learning tools

Abstract— ECG (electrocardiogram) data classification has a great variety of applications in health monitoring and diagnosis facilitation. In this paper, previous work on automatic ECG data classification is overviewed, the idea of applying deep learning tools, i.e. caffe is proposed, and the classification system is built. Result shows the effectiveness of Convolutional Neural Network as the method to ECG classification.
The influence of eWOM in social media on consumers' purchase intentions: An extended approach to information adoption

Social media websites have created valuable opportunities for electronic word of mouth (eWOM) conversations. People are now able to discuss products and services of brands with their friends and acquaintances. The aim of this study is to examine the influence of these conversations in social media on consumers' purchase intentions. For this purpose, a conceptual model was developed based on the integration of Information Adoption Model (IAM) and related components of Theory of Reasoned Action (TRA). The new model, which is named as Information Acceptance Model (IACM), was validated through structural equation modelling (SEM) based on surveys of 384 university students who use social media websites. The results confirm that quality, credibility, usefulness and adoption of information, needs of information and attitude towards information are the key factors of eWOM in social media that influence consumers’ purchase intentions. Theoretical and practical implications are discussed as well as recommendations for further research. © 2016 Elsevier Ltd. All rights reserved.
Investigation of rheumatoid arthritis susceptibility genes identifies association of AFF3 and CD226 variants with response to anti-tumour necrosis factor treatment

BACKGROUND
Anti-tumour necrosis factor (anti-TNF) therapy has proved to be highly successful in treating rheumatoid arthritis (RA), although 30-40% of patients have little or no response. The authors hypothesise that this may be genetically determined. In other complex diseases, susceptibility genes have been shown to influence treatment response. The aim of the current study was to investigate the association of markers within confirmed RA susceptibility loci with the response to anti-TNF treatment.


METHODS
Eighteen single nucleotide polymorphisms (SNPs) mapping to 11 genetic loci were genotyped in 1012 patients with RA receiving treatment with etanercept, infliximab or adalimumab. Multivariate linear regression analyses were performed using the absolute change in 28 joint count disease activity score (DAS28) between baseline and 6-month follow-up as the outcome variable, adjusting for confounders. p Values <0.05 were considered statistically significant and associated markers were genotyped in an additional 322 samples. Analysis was performed in the combined cohort of 1334 subjects with RA treated with anti-TNF.


RESULTS
In the combined analysis, SNPs mapping to AFF3 and CD226 had a statistically significant association with the response to anti-TNF treatment under an additive model. The G allele at rs10865035, mapping to AFF3, was associated with an improved response to anti-TNF treatment (coefficient -0.14 (95% CI -0.25 to -0.03), p=0.015). At the CD226 SNP rs763361, the C allele conferred reduced response to treatment (coefficient 0.11 (95% CI 0.00 to 0.22), p=0.048).


CONCLUSION
These results suggest that AFF3 and CD226, two confirmed RA susceptibility genes, have an additional role in influencing the response to anti-TNF treatment.
Running in ostriches (Struthio camelus): three-dimensional joint axes alignment and joint kinematics.

Although locomotor kinematics in walking and running birds have been examined in studies exploring many biological aspects of bipedalism, these studies have been largely limited to two-dimensional analyses. Incorporating a five-segment, 17 degree-of-freedom (d.f.) kinematic model of the ostrich hind limb developed from anatomical specimens, we quantified the three-dimensional (3-D) joint axis alignment and joint kinematics during running (at approximately 3.3 m s(-1)) in the largest avian biped, the ostrich. Our analysis revealed that the majority of the segment motion during running in the ostrich occurs in flexion/extension. Importantly, however, the alignment of the average flexion/extension helical axes of the knee and ankle are rotated externally to the direction of travel (37 degrees and 21 degrees , respectively) so that pure flexion and extension at the knee will act to adduct and adbuct the tibiotarsus relative to the plane of movement, and pure flexion and extension at the ankle will act to abduct and adduct the tarsometatarsus relative to the plane of movement. This feature of the limb anatomy appears to provide the major lateral (non-sagittal) displacement of the lower limb necessary for steering the swinging limb clear of the stance limb and replaces what would otherwise require greater adduction/abduction and/or internal/external rotation, allowing for less complex joints, musculoskeletal geometry and neuromuscular control. Significant rotation about the joints' non-flexion/extension axes nevertheless occurs over the running stride. In particular, hip abduction and knee internal/external and varus/valgus motion may further facilitate limb clearance during the swing phase, and substantial non-flexion/extension movement at the knee is also observed during stance. Measurement of 3-D segment and joint motion in birds will be aided by the use of functionally determined axes of rotation rather than assumed axes, proving important when interpreting the biomechanics and motor control of avian bipedalism.
Long-term outcomes and prognostic factors in patients treated with intraoperatively planned prostate brachytherapy.

PURPOSE
Evaluate outcomes and prognostic factors in men with localized prostate cancer.


METHODS AND MATERIALS
A total of 3760 patients have undergone prostate seed implantation at our institution. This review is of our initial 304 consecutive patients treated before January 30, 2001. A total of 124 patients were treated with (125)I implant monotherapy and 180 with (103)Pd implant combined with 45-Gy external beam radiation therapy.


RESULTS
The median followup was 10.3 years. A 10-year biochemical control for low risk (LR) was 98% , intermediate risk (IR) 94%, high risk (HR) 78%, and HR with one HR factor 88% (p < 0.001); cause-specific survival was 99%, 98%, and 84% for LR, IR, and HR, respectively (p < 0.001); No significant difference in outcome was seen for LR and IR patients (p > 0.3). On multivariate analysis, only pretreatment PSA, Gleason score, and T-stage were significant for biochemical control. Most biochemical failures occurred within 5 years (93%).


CONCLUSIONS
With a minimum followup of 10 years, results are excellent and do not differ for LR or IR prostate cancer patients. HR patients are a very heterogeneous group, and excellent results can still be achieved for HR patients with only one HR feature.