LLukas22/scidocs huggingface dataset:
Allergies are still on the rise? A 6-year nationwide population-based study in Korea.

BACKGROUND
Some western countries recently have shown a slowdown in the incidence of allergic diseases after worldwide increasing trends, but there are few data from Asian populations concerning changing trend of allergic diseases. We evaluated the recent trends in the prevalence of asthma and other allergic diseases in Korea.


METHODS
From the database of Korean National Health Insurance, a nationwide diagnostic data from 2009 to 2014 were extracted and the national prevalence was analyzed.


RESULTS
The prevalence per 1000 people of atopic dermatitis, allergic rhinitis, and asthma in 2014 was 19.0, 133.1, and 36.3, respectively. The prevalence of three diseases was highest in the age group under 10 as, 95.0, 384.1, and 132.1 per 1000 people, while the prevalence in the over-10-year-group was only 11.6, 109.5, and 27.3, respectively. The prevalence of atopic dermatitis and allergic rhinitis gradually decreased with older age, but the prevalence of asthma showed a re-increasing pattern from the age group 30-39 and reached another peak for the age group 70-79. During the study period, the prevalence of asthma and atopic dermatitis showed decreasing tendency. In contrast, the prevalence of allergic rhinitis steadily increased until 2013, especially in the age group under 10.


CONCLUSIONS
The national prevalence of atopic dermatitis, and asthma did not show noticeable increase any more in Korea. However, the prevalence of allergic rhinitis still on the rise until recently, especially in the age group under 10. This is the first report in Asia suggesting a slowdown of the incidence of allergic diseases.
Prucalopride Improves Bowel Function and Colonic Transit Time in Patients With Chronic Constipation: An Integrated Analysis

Objectives:Constipation is often characterized by slow colonic transit, but the relationship between colonic transit time (CTT) and symptoms is unclear. The aims of this study were to investigate the effect of prucalopride, a 5-hydroxytryptamine receptor-4 agonist, on CTT and assess the relationship between CTT and symptoms.Methods:This was an integrated analysis of three randomized, placebo-controlled, phase 2 dose-finding trials of prucalopride in patients with chronic constipation (ClinicalTrials.gov identifiers: NCT00617513; NCT00631813; and NCT00596596). Measurements of CTT were analyzed using radio-opaque markers at the start and end (4 or 12 weeks) of treatment. At these visits, patients assessed the presence and severity of their symptoms.Results:In total, 280 patients had CTT measurements before and at the end of treatment and were included in the analysis. Their mean age was 43 years, 93% were women, and mean duration of constipation was 19 years. After a once daily treatment with prucalopride 2 mg (n=98) and 4 mg (n=70), CTT was reduced by 12.0 h (95% confidence interval (CI): –18.9, –5.1) and 13.9 h (95% CI: –20.5, –7.4), respectively; CTT increased by 0.5 h (95% CI: –4.5, 5.5) with placebo (n=112). At the end of the trial, symptoms including bloating/flatulence/distension and straining were rated as severe or very severe by a higher proportion of patients with slow or very slow CTT (>48 h) than by those with normal CTT.Conclusions:There was a clear relationship between increased CTT and increased symptom severity in patients with chronic constipation. Treatment with prucalopride accelerated CTT in these individuals.
NT-proBNP and troponin T and risk of rapid kidney function decline and incident CKD in elderly adults.

BACKGROUND AND OBJECTIVES
Elevations in N-terminal pro-B-type natriuretic peptide and high-sensitivity troponin T are associated with poor cardiovascular outcomes. Whether elevations in these cardiac biomarkers are associated with decline in kidney function was evaluated.


DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS
N-terminal pro-B-type natriuretic peptide and troponin T were measured at baseline in 3752 participants free of heart failure in the Cardiovascular Health Study. eGFR was determined from the Chronic Kidney Disease Epidemiology Collaboration equation using serum cystatin C. Rapid decline in kidney function was defined as decline in serum cystatin C eGFR≥30%, and incident CKD was defined as the onset of serum cystatin C eGFR<60 among those without CKD at baseline (n=2786). Cox regression models were used to examine the associations of each biomarker with kidney function decline adjusting for demographics, baseline serum cystatin C eGFR, diabetes, and other CKD risk factors.


RESULTS
In total, 503 participants had rapid decline in serum cystatin C eGFR over a mean follow-up time of 6.41 (1.81) years, and 685 participants developed incident CKD over a mean follow-up time of 6.41 (1.74) years. Participants in the highest quartile of N-terminal pro-B-type natriuretic peptide (>237 pg/ml) had an 67% higher risk of rapid decline and 38% higher adjusted risk of incident CKD compared with participants in the lowest quartile (adjusted hazard ratio for serum cystatin C eGFR rapid decline, 1.67; 95% confidence interval, 1.25 to 2.23; hazard ratio for incident CKD, 1.38; 95% confidence interval, 1.08 to 1.76). Participants in the highest category of troponin T (>10.58 pg/ml) had 80% greater risk of rapid decline compared with participants in the lowest category (adjusted hazard ratio, 1.80; 95% confidence interval, 1.35 to 2.40). The association of troponin T with incident CKD was not statistically significant (hazard ratio, 1.17; 95% confidence interval, 0.92 to 1.50).


CONCLUSIONS
Elevated N-terminal pro-B-type natriuretic peptide and troponin T are associated with rapid decline of kidney function and incident CKD. Additional studies are needed to evaluate the mechanisms that may explain this association.
Comparative Study of Antenna Designs for RF Energy Harvesting

In the last few years, several antenna designs of rectenna that meet various objectives have been proposed for use in RF energy harvesting. Among various antennas,microstrip patch antennas arewidely used because of their low profile, light weight, and planar structure. Conventional patch antennas are rectangular or circular in shape, but variations in their basic design aremade for different purposes. This paper begins with an explanation and discussion of different designs, put forward with an aim of miniaturization, harmonic rejection, and reconfigurability. Finally, microstrip patch structured rectennas are evaluated and compared with an emphasis on the various methods adopted to obtain a compact rectenna, harmonic rejection functionality, and frequency and polarization selectivity.
Digital circuit design using intrinsic evolvable hardware

This paper describes the application of intrinsic evolvable hardware to combinational circuit design and synthesis, as an alternative to conventional approaches. This novel reconfigurable architecture is inspired by Cartesian genetic programming and dedicated for implementing high performance digital image filters on a custom Xilinx Virtex FPGA xcv1000, together with a flexible local interconnection hierarchy. As a highly parallel architecture, it scales linearly with the filter complexity. It is reconfigured by an external genetic reconfiguration processing unit with a hardware GA implementation embedded. Due to pipelining, parallelization and no function call overhead, it yields a significant speedup of one to two orders of magnitude over a software implementation, which is especially useful for the real-time applications. The experimental results conclude that in terms of computational effort, filtered image signal and implementation cost, the intrinsic evolvable hardware solution outperforms traditional approaches.
Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies

 Choosing the best genetic strains of mice for developing a new knockout or transgenic mouse requires extensive knowledge of the endogenous traits of inbred strains. Background genes from the parental strains may interact with the mutated gene, in a manner which could severely compromise the interpretation of the mutant phenotype. The present overview summarizes the literature on a wide variety of behavioral traits for the 129, C57BL/6, DBA/2, and many other inbred strains of mice. Strain distributions are described for open field activity, learning and memory tasks, aggression, sexual and parental behaviors, acoustic startle and prepulse inhibition, and the behavioral actions of ethanol, nicotine, cocaine, opiates, antipsychotics, and anxiolytics. Using the referenced information, molecular geneticists can choose optimal parental strains of mice, and perhaps develop new embryonic stem cell progenitors, for new knockouts and transgenics to investigate gene function, and to serve as animal models in the development of novel therapeutics for human genetic diseases.
The B2C group-buying model on the Internet

Internet-based group-buying has become a new growth point for China's e-commerce. By studying B2C group-buying model, this paper has collected data of 20 major Chinese group-buying websites, studied factors that might influence Internet users' group-buying behavior, proposed a new model for evaluating the value of Internet enterprises, and provided a feasible reference model for the evaluation and performance of Internet enterprises.
User-Driven Development for UK M-Health Patient Management System

M-health applications have been gaining importance in the recent years and has been the focus of many researchers due to its advantages of effective service delivery with cost-effective mechanisms. The existing m-health systems are reviewed in this paper and many issues are identified with them, which are mostly user-centric. Whilst there are recognised standards, such as ISO 13407, which highlight the need for user centric development, the majority of application development considers low user involvement in the development process, which either results in developing a system that does not fulfil the outlined objectives or only partially doing so. Considering this issue, an agile user centred design methodology for developing an m-health patient management system is proposed. In addition, an online questionnaire-based survey and interviews are conducted for assessing the users’ needs and expectations from this patient management m-health system. The interview and survey results indicate that cost, ease of use, accuracy, privacy, security, effectiveness, durability, adaptability, support, learnability and enjoyability are the important factors that need to be considered in a user centric design methodology. From the study, it is concluded that the results from the survey and interviews can be useful for designing and developing user centric m-health systems.
Existence and uniqueness theorem for uncertain differential equations

Canonical process is a Lipschitz continuous uncertain process with stationary and independent increments, and uncertain differential equation is a type of differential equations driven by canonical process. This paper presents some methods to solve linear uncertain differential equations, and proves an existence and uniqueness theorem of solution for uncertain differential equation under Lipschitz condition and linear growth condition.
Habitual and Occasional Lobbyers in the U.S. Steel Industry: An EM Algorithm Pooling Approach

Using U.S. steel firm data, we find that lobbying for import protection appears to be habit-forming. To identify heterogeneity in lobbying behavior among firms, we use an expectation-maximization algorithm to sort our firms into groups with different propensities to lobby and estimate the determinants of lobbying in each group. A two-pool model emerges: occasional lobbyers' lobbying depends on their market performance, and habitual lobbyers' lobbying only depends on past lobbying. The latter tends to be larger steel firms whose business is more focused in steel. Our evidence is consistent with dynamic economies of scale in protection seeking breeding protection-dependent firms. Copyright 2001 by Oxford University Press.
Mind Reading: Neural Mechanisms of Theory of Mind and Self-Perspective

Human self-consciousness as the metarepresentation of ones own mental states and the so-called theory of mind (TOM) capacity, which requires the ability to model the mental states of others, are closely related higher cognitive functions. We address here the issue of whether taking the self-perspective (SELF) or modeling the mind of someone else (TOM) employ the same or differential neural mechanisms. A TOM paradigm was used and extended to include stimulus material that involved TOM and SELF capacities in a two-way factorial design. A behavioral study in 42 healthy volunteers showed that TOM and SELF induced differential states of mind: subjects assigned correctly first or third person pronouns when providing responses to the stimuli. Following the behavioral study, we used functional magnetic resonance imaging (fMRI) in eight healthy, right-handed males to study the common and differential neural mechanisms underlying TOM and SELF. The main factor TOM led to increased neural activity in the anterior cingulate cortex and left temporopolar cortex. The main factor SELF led to increased neural activity in the right temporoparietal junction and in the anterior cingulate cortex. A significant interaction of both factors TOM and SELF was observed in the right prefrontal cortex. These divergent neural activations in response to TOM and SELF suggest that these important differential mental capacities of human self-consciousness are implemented at least in part in distinct brain regions. Press
James Watson ’ s most inconvenient truth : Race realism and the moralistic fallacy

Recent editorials in this journal have defended the right of eminent biologist James Watson to raise the unpopular hypothesis that people of sub-Saharan African descent score lower, on average, than people of European or East Asian descent on tests of general intelligence. As those editorials imply, the scientific evidence is substantial in showing a genetic contribution to these differences. The unjustified ill treatment meted out to Watson therefore requires setting the record straight about the current state of the evidence on intelligence, race, and genetics. In this paper, we summarize our own previous reviews based on 10 categories of evidence: The worldwide distribution of test scores; the g factor of mental ability; heritability differences; brain size differences; trans-racial adoption studies; racial admixture studies; regression-to-the-mean effects; related life-history traits; human origins research; and the poverty of predictions from culture-only explanations. The preponderance of evidence demonstrates that in intelligence, brain size, and other life-history variables, East Asians average a higher IQ and larger brain than Europeans who average a higher IQ and larger brain than Africans. Further, these group differences are 50–80% heritable. These are facts, not opinions and science must be governed by data. There is no place for the ‘‘moralistic fallacy’’ that reality must conform to our social, political, or ethical desires. !c 2008 Elsevier Ltd. All rights reserved.
Risk of Malignancy and Need for Surgery in Pediatric Patients with Morris or Y-chromosome Turner Syndrome: A Multicenter Survey.

STUDY OBJECTIVE
The management of intersex patients with Y-chromosome Turner or Morris syndrome remains a challenge. We report our experience with a multicenter European survey.


DESIGN
We collected the data on 18 patients (mean age 10.2 years, range 2-17 years) with Morris (10 patients) or Turner (8 patients) syndrome harboring the Y chromosome who were treated in 1 of 6 European centers of pediatric surgery between 1997 and 2013. All patients were evaluated by use of a multidisciplinary diagnostic protocol. All patients received a bilateral gonadectomy via laparoscopy; only 1 center performed ovarian cryopreservation. Seven patients received a concomitant genitoplasty. Operative notes and histology were reviewed for details.


RESULTS
No conversions to laparotomy and no complications were recorded. For the patients receiving only the gonadectomy, the length of hospital stay was 24-48 hours, whereas for the patients receiving an associated genitoplasty, it was 6-10 days. Specimens were negative for tumors in 83.3% of cases, whereas in 3 patients (16.6%), benign abnormalities (Sertoli cell hyperplasia in 1 patient and ovotestis in 2 patients) were recorded. A malignant tumor was not recorded in our series.


CONCLUSION
If the risk of malignancy is considered as the main indication for surgery in case of Turner or Morris syndrome, on the basis of our study, this indication should be reevaluated. However, based on the non-negligible rate of benign abnormalities reported in our series (16.6%), the performance of cryopreservation to preserve fertility and the possibility of performing genitoplasty during the same anesthetic procedure represent additional valid indications for surgery.
Gaps in the Continuum of HIV Care: Long Pretreatment Waiting Time between HIV Diagnosis and Antiretroviral Therapy Initiation Leads to Poor Treatment Adherence and Outcomes

Background. Criteria for antiretroviral treatment (ART) were adjusted to enable early HIV treatment for people living HIV/AIDS (PLHIV) in China in recent years. This study aims to determine how pretreatment waiting time after HIV confirmation affects subsequent adherence and outcomes over the course of treatment. Methods. A retrospective observational cohort study was conducted using treatment data from PLHIV in Yuxi, China, between January 2004 and December 2015. Results. Of 1,663 participants, 348 were delayed testers and mostly initiated treatment within 28 days. In comparison, 1,315 were nondelayed testers and the median pretreatment waiting time was 599 days, but it significantly declined over the study period. Pretreatment CD4 T-cell count drop (every 100 cells/mm3) contributed slowly in CD4 recovery after treatment initiation (8% less, P < 0.01) and increased the risk of poor treatment adherence by 15% (ARR = 1.15, 1.08-1.25). Every 100 days of extensive pretreatment waiting time increased rates of loss to follow-up by 20% (ARR = 1.20, 1.07-1.29) and mortality rate by 11% (ARR = 1.11, 1.06-1.21), based on multivariable Cox regression. Conclusion. Long pretreatment waiting time in PLHIV can lead to higher risk of poor treatment adherence and HIV-related mortality. Current treatment guidelines should be updated to provide ART promptly.
The Price Impact of Order Book Events

We study the price impact of order book events limit orders, market orders and cancelations using the NYSE TAQ data for 50 U.S. stocks. We show that, over short time intervals, price changes are mainly driven by the order flow imbalance, defined as the imbalance between supply and demand at the best bid and ask prices. Our study reveals a linear relation between order flow imbalance and price changes, with a slope inversely proportional to the market depth. These results are shown to be robust to seasonality effects, and stable across time scales and across stocks. We argue that this linear price impact model, together with a scaling argument, implies the empirically observed “square-root” relation between price changes and trading volume. However, the relation between price changes and trade volume is found to be noisy and less robust than the one based on order flow imbalance.
Design of advanced digital heartbeat monitor using basic electronic components

This paper illustrates the design of an efficient, stable, accurate and cheap digital heartbeat monitor which accepts the mechanical heartbeat pulses as input, converts them into the electrical form, amplifies them and provides the necessary output on a 7 segment display following a basic logic algorithm. The reading which is obtained in the seven segments is made error free by using suitable cascading flip flop mechanism. An accurate result is thus obtained.
EEG Source Imaging Enhances the Decoding of Complex Right-Hand Motor Imagery Tasks

Goal: Sensorimotor-based brain-computer interfaces (BCIs) have achieved successful control of real and virtual devices in up to three dimensions; however, the traditional sensor-based paradigm limits the intuitive use of these systems. Many control signals for state-of-the-art BCIs involve imagining the movement of body parts that have little to do with the output command, revealing a cognitive disconnection between the user's intent and the action of the end effector. Therefore, there is a need to develop techniques that can identify with high spatial resolution the self-modulated neural activity reflective of the actions of a helpful output device. Methods: We extend previous EEG source imaging (ESI) work to decoding natural hand/wrist manipulations by applying a novel technique to classifying four complex motor imaginations of the right hand: flexion, extension, supination, and pronation. Results: We report an increase of up to 18.6% for individual task classification and 12.7% for overall classification using the proposed ESI approach over the traditional sensor-based method. Conclusion: ESI is able to enhance BCI performance of decoding complex right-hand motor imagery tasks. Significance: This study may lead to the development of BCI systems with naturalistic and intuitive motor imaginations, thus facilitating broad use of noninvasive BCIs.
Serum uric acid and multiple sclerosis

Several studies indicate that patients with multiple sclerosis (MS) have low serum levels of the endogenous antioxidant uric acid (UA), although it has not been established whether UA is primarily deficient or secondarily reduced due to its peroxynitrite scavenging activity. We measured serum urate levels in 124 MS patients and 124 age- and sex-matched controls with other neurological diseases. In addition, we compared UA levels when MS patients were stratified according to disease activity (by means of clinical examination and MRI), duration, disability and course. MS patients had significantly lower serum urate levels than controls (p= 0.001). However, UA levels did not significantly correlate with disease activity, duration, disability or course. Our study favors the view that reduced UA in MS is a primary, constitutive loss of protection against oxidative agents, which deserves further pathogenetic elucidation aimed at future therapeutic strategies.
CloudExp: A comprehensive cloud computing experimental framework

Cloud computing is an emerging and fast-growing computing paradigm that has gained great interest from both industry and academia. Consequently, many researchers are actively involved in cloud computing research projects. One major challenge facing cloud computing researchers is the lack of a comprehensive cloud computing experimental tool to use in their studies. This paper introduces CloudExp, a modeling and simulation environment for cloud computing. CloudExp can be used to evaluate a wide spectrum of cloud components such as processing elements, data centers, storage, networking, Service Level Agreement (SLA) constraints, web-based applications, Service Oriented Architecture (SOA), virtualization, management and automation, and Business Process Management (BPM). Moreover, CloudExp introduces the Rain workload generator which emulates real workloads in cloud environments. Also, MapReduce processing model is integrated in CloudExp in order to handle the processing of big data problems. 2014 Elsevier B.V. All rights reserved.