LLukas22/scidocs huggingface dataset:
The Spanish version of the Work-related Acceptance and Action Questionnaire (WAAQ).

BACKGROUND
Psychological flexibility, a key construct of Acceptance and Commitment Therapy (ACT), has recently been found to be an important determinant of mental health and behavioral effectiveness in the workplace. This finding has led to designing a measure of psychological flexibility especially tailored to the workplace (the Work-related Acceptance and Action Questionnaire; WAAQ) in the hope that it may reveal even stronger associations with variables related to a work context.


METHOD
First, we back-translated the WAAQ into Spanish and then administered it to 209 workers, in addition to other relevant work-related measures.


RESULTS
Data were very similar to those obtained with the original WAAQ version. The WAAQ showed a very good internal consistency (a = .92) and a clear one-factor structure. It also showed higher correlations with work-specific measures than a general measure of psychological inflexibility (the Acceptance and Action Questionnaire-II; AAQ-II). As hypothesized by the ACT theory, the correlation between the WAAQ and the AAQ-II was moderate but not so high as to suggest that they are assessing the same construct.


CONCLUSIONS
This Spanish translation of the WAAQ emerges as a reliable and valid measure of psychological flexibility in relation to the workplace.
[Gender-specific differences in quality of life of patients with type 2 diabetes with or without participating in DMP].

OBJECTIVE
Disease management programmes (DMP) are supposed to improve the care of patients with type 2 diabetes or other chronic conditions. One stated aim is the improvement of the health-related quality of life. Within the ELSID study (controlled study for the evaluation of the DMP for patients with type 2 diabetes) there has been a survey of insurants of the general regional health funds (AOK) by means of the SF-36. The aim of this survey is a comparison of patients participating in the Diabetes DMP with those who are not participating in the program with regard to their quality of life.


METHODS
A random sample of 3,546 patients with type 2 diabetes out of the total sample of the ELSID study (20,625) was asked to complete the SF-36.


RESULTS
1,532 questionnaires were returned (response rate 43.2%). 1,399 were analysed. Within all scales of the SF-36, men achieved higher scores than women. Differentiated in participants and non-participants in the DMP, in men there were lower scores for the participants than for the non-participants. In women this proportion was reversed.


CONCLUSIONS
This cross-sectional-study provides first indications for gender-specific differences within the quality of life of patients with diabetes participating in the DMP compared to patients who are not participating. These differences should be considered more intensely within further research of DMP evaluation and the configuration of the programmes in the future.
A simple proof of Xia's proposition

This paper studies a spectral property of a k-tuple of hyponormal operators T = (T1, ..., Tn) with compact self commutators. Mathematics Subject Classification: 47B20 This research is partially supported by Grant-in-Aid Research No. 17540176. This research is partially supported by Grant-in-Aid Research No. 17740086. 2080 M. Chō, T. Huruya and M. Seto
Sustainable and Resilient Supply Chain Network Design under Disruption Risks

Sustainable supply chain network design is a rich area for academic research that is still in its infancy and has potential to affect supply chain performance. Increasing regulations for carbon and waste management are forcing firms to consider their supply chains from ecological and social objectives, but in reality, however, facilities and the links connecting them are disrupted from time to time, due to poor weather, natural or manmade disasters or a combination of any other factors. Supply chain systems drop their sustainability objectives while coping with these unexpected disruptions. Hence, the new challenges for supply chain managers are to design an efficient and effective supply chain network that will be resilient enough to bounce back from any disruption and that also should have sufficient vigilance to offer same sustainability under a disruption state. This paper focuses on ecological sustainability, because an environmental focus in a supply chain system is more important and also links with other pillars of sustainability, as the products need to be produced, packed and transported in an ethical way, which should not harm social balance and the environment. Owing to importance of the considered issue, this paper attempts to introduce a network optimization model for a sustainable and resilient supply chain network by incorporating (1) sustainability via carbon emissions and embodied carbon footprints and (2) resilience by incorporating location-specific risks. The proposed goal programming (GP) OPEN ACCESS Sustainability 2014, 6 6667 model optimizes the total cost, while considering the resilience and sustainability of the supply chain network.
National Mass Gathering Pharmaceutical Care Program at MOH in Saudi Arabia

WHO indicted mass gathering if there are more 1000 person in one place at the same time.[1] This is precisely in Hajj and Omra gathering. Each year the number of pilgrims each year ranging of 1,980,249-3,161,573 based on statistics years 2006-2014. Those pilgrims divide into two types of pilgrims who come from inside Saudi Arabia. It is account ranging of 600,718-1,408,641 pilgrims. The second category called outside pilgrims who come from outside Saudi Arabia; it is ranging 1,379,531-1,828,195 pilgrims. [2] Ministry of Health (MOH) provides excellent health care services to those pilgrims. In 2014; for instance, but not limited to these are, Seventeen permanent hospitals, eight seasonal (temporary) general hospitals, 44 permanent primary health center, 114 seasonal (temporary) primary health care centers. Those contain 4141 beds and 458 Intensive care beds. MOH arranged 24040 of Healthcare providers, 28.5 % repressed as allied health care personnel who are including the pharmacists.[2]
Branched-Chain Amino Acids : Metabolism , Physiological Function , and Application Branched-Chain Amino Acids Activate Key Enzymes in Protein Synthesis after Physical Exercise 1 – 3

BCAAs (leucine, isoleucine, and valine), particularly leucine, have anabolic effects on protein metabolism by increasing the rate of protein synthesis and decreasing the rate of protein degradation in resting human muscle. Also, during recovery from endurance exercise, BCAAs were found to have anabolic effects in human muscle. These effects are likely to be mediated through changes in signaling pathways controlling protein synthesis. This involves phosphorylation of the mammalian target of rapamycin (mTOR) and sequential activation of 70-kD S6 protein kinase (p70 S6 kinase) and the eukaryotic initiation factor 4E-binding protein 1. Activation of p70 S6 kinase, and subsequent phopsphorylation of the ribosomal protein S6, is associated with enhanced translation of specific mRNAs. When BCAAs were supplied to subjects during and after one session of quadriceps muscle resistance exercise, an increase in mTOR, p70 S6 kinase, and S6 phosphorylation was found in the recovery period after the exercise with no effect of BCAAs on Akt or glycogen synthase kinase 3 (GSK-3) phosphorylation. Exercise without BCAA intake led to a partial phosphorylation of p70 S6 kinase without activating the enzyme, a decrease in Akt phosphorylation, and no change in GSK-3. It has previously been shown that leucine infusion increases p70 S6 kinase phosphorylation in an Akt-independent manner in resting subjects; however, a relation between mTOR and p70 S6 kinase has not been reported previously. The results suggest that BCAAs activate mTOR and p70 S6 kinase in human muscle in the recovery period after exercise and that GSK-3 is not involved in the anabolic action of BCAAs on human muscle. J. Nutr. 136: 269S–273S, 2006.
Determining the limits of anaerobic co-digestion of thickened waste activated sludge with grease interceptor waste.

Anaerobic co-digestion of thickened waste activated sludge (TWAS) with grease interceptor waste (GIW) from a food service establishment was conducted in lab scale semi-continuous digesters. GIW included the entire contents of the grease interceptor (GI) including fat, oil, and grease (FOG), food residuals, and associated wastewater. GIW was added in step increases to identify the maximum methane production and the corresponding threshold input of GIW that led to inhibition of methanogenesis. The experiment was performed at mesophilic conditions (37 °C) with a solids retention time (SRT) of 20 days. The highest GIW addition rate achieved without digester failure was 20% (v/v), or 65.5% (w/w) of volatile solids (VS) added, enhancing the methane yield from 0.180 to 0.752 m3(CH4)/kg(VS added), biogas production from 2.2 × 10(-3) to 1.4 × 10(-2) m(3)/d, and methane content from 60.2% to 70.1%. The methane yield of 0.752 m3(CH4)/kg(VS added) is the highest value reported to date for co-digestion of GIW. Stepwise increases in co-substrate addition led to better microbial acclimation and reduced the GIW inhibitory effect. The limit for GIW addition leading to an inhibited digestion process was identified to be between 20 and 40% (v/v) or 65.5 and 83.5% (w/w) of VS added. The results show the significant benefits of anaerobic co-digestion of GIW and the positive impacts of gradual addition of GIW.
Detecting psychological distress: can general practitioners improve their own performance?

BACKGROUND
Many studies have suggested that general practitioners fail to detect a substantial minority of their patients who are psychologically distressed, and there is concern about the possible sequelae of this. Individual patients may suffer unresolved problems, and there are potential costs to the health service in consequent recurrent consultations, inappropriate referrals or treatment. Educational interventions based on small groups led by facilitators have been shown to alter the consultation behaviours of general practitioners that are known to be related to accurate detection of psychological distress.


AIM
This controlled study aimed to show that, by utilizing a brief self-directed educational intervention focusing on detection of psychological distress, general practitioners can improve their performance significantly. For this purpose, a new educational intervention was designed: the second aim of the study was thus to assess the effectiveness of this specific intervention.


METHOD
An educational intervention was designed which focused on skills relevant to detecting psychological distress, using the principles of reflection on general practitioner performance and consultation skill work. It was designed to be used by individual general practitioners without outside support, using a combination of written background material, feedback on performance and analysis of video material. The effectiveness of the intervention was tested by comparing a trial and control cohort of general practitioners, using detection rates as an outcome measure.


RESULTS
The detection rate of the general practitioners who underwent the intervention improved significantly compared with their performance before intervention and with that of the control group.


CONCLUSION
General practitioners can improve their ability to detect psychological distress in their patients utilizing this self-directed educational approach.
Sevelamer carbonate lowers serum phosphorus effectively in haemodialysis patients: a randomized, double-blind, placebo-controlled, dose-titration study.

BACKGROUND
Hyperphosphataemia in patients with advanced chronic kidney disease (CKD) is associated with adverse outcomes, including vascular calcification and higher mortality rates. While phosphate lowering is an integral aspect of CKD management, the efficacy and safety of phosphate binders in a contemporary cohort of Chinese haemodialysis patients (who have different genetics and dietary patterns than other populations) has not been previously described. Moreover, sparse data are available on strategies for optimal dose titration when transitioning from a calcium-based to a polymer-based phosphate binder.


METHODS
This randomized, double-blind, dose-titration study compared sevelamer carbonate (starting dose 800 mg three times daily) with placebo over 8 weeks' duration in Chinese CKD patients on haemodialysis. Patients were required to be using calcium-based binders prior to study start.


RESULTS
In all, 205 patients were randomized (sevelamer, n = 135; placebo, n = 70); mean age was 48.6 years, 61% were male and the mean time on dialysis was 4.4 years. The mean serum phosphorus decreased significantly in patients treated with sevelamer carbonate [change -0.69 ± 0.64 mmol/L (-2.14 ± 1.98 mg/dL)] but remained persistently elevated with placebo [change -0.06 ± 0.57 mmol/L (-0.19 ± 1.76 mg/dL)] (P < 0.0001). When compared with placebo, sevelamer carbonate treatment resulted in statistically significant greater mean reductions from baseline in serum total (-17.1 versus -3.3%) and low-density lipoprotein cholesterol (-33.5 versus-7.6%) (P < 0.0001 for both). Sevelamer carbonate was well tolerated with 96% adherence compared with 97% adherence in the placebo arm. Overall, adverse events experienced by patients in the sevelamer carbonate and placebo treatment groups were similar and consistent with their underlying renal disease.


CONCLUSIONS
This study demonstrated that hyperphosphataemia developed quickly following the cessation of phosphate binders and remained persistently elevated in end-stage CKD in the placebo-treated group. Gradually titrating up sevelamer carbonate from an initial dose of 2.4 g/day to an average daily dose of 7.1 ± 2.5 g/day was well tolerated, safe and efficacious in contemporary Chinese haemodialysis patients.
Continuous dopaminergic stimulation and novel formulations of dopamine agonists

There is now accumulating evidence that the combination of progressive pathology of Parkinson’s disease, the change in drug pharmacodynamics, and the pulsatile manner in which short-acting dopaminergic agents stimulate striatal dopamine receptors are the key contributing factors to the priming of the basal ganglia for induction of motor complications. Long-acting drugs provide a more physiological dopaminergic stimulation. Dopamine agonists have been extensively used as monotherapy and add-on therapy to levodopa to treat Parkinson’s disease in the early stage and with motor complications. Today, the new long-acting formulation offers the advantages of an easy use and a more continuous delivery of drug. In this paper the role of new formulations of dopamine agonists in the treatment of parkinsonian patients at different stages of the disease is reviewed.
Assisted Reproductive Technology after the Birth of Louise Brown

BACKGROUND
Public interest in Assisted Reproductive Technology (ART) has remained high since the birth of the world's first in vitro fertilization baby, Louise Brown, in the United Kingdom. ART allows scientists to manipulate the fertilization process in order to bypass some pathological obstacles such as blocked fallopian tubes and non-functioning ovaries in the females, and blocked vas deferens and low sperm count in the males. The purpose was to provide a historical outline and identify the researches that most contributed to ART.


METHODS
A review of published experimental and clinical studies of assisted reproduction carried out at the University of Bristol library website (MetaLib(®)). A cross-search of seven different medical databases (AMED-Allied and Complementary Medicine Database, BIOSIS Previews on Web of Knowledge, Cochrane Library, Embase, and the Medline on Web of Knowledge, OvidSP and PubMed) was completed by using the key words to explore the major milestones and progress in the development and implementation of ART.


RESULTS
A speedy advancement in the development of different assisted reproductive techniques makes infertility problem more treatable than it ever had been.


CONCLUSION
Although no other field in the medicine has integrated new knowledge into the daily practice more quickly than ART yet, there is a need for social research to counterbalance the dominance of biomedical one, in particular the people's actual experiences and expectations of ART.
FATIGUE LIFE IMPROVEMENT OF AN ALUMINUM ALLOY FSW WITH LOW PLASTICITY BURNISHING

Friction stir welding provides a new technology for solid state joining of a wide variety of aluminum alloys that cannot be joined with conventional fusion welds. However, recent work has shown that significant tensile residual stresses are developed in the stirred region with local tension maxima at the transition between the stir and heat-affected zones. Residual tension at the edges of the stir zone has been associated with stress corrosion cracking and corrosion fatigue crack growth initiation. This fatigue debit has been overcome using low plasticity burnishing (LPB) to introduce a deep surface layer of compressive residual stress. LPB processing after friction stir welding has increased the high cycle fatigue endurance of aluminum alloy FSW by 80%. However, the LPB processing parameters have not yet been optimized to produce the maximum achievable fatigue life. A linear elastic fracture mechanics approach is applied to calculate the fatigue crack growth rates and fatigue lives of friction stir welded 2219-T8751 aluminum with initiation from salt fog pitting. The analysis is performed with and without the including of the deep compressive residual stresses produced by low plasticity burnishing (LPB). Calculated fatigue lives are compared to fatigue data developed in fourpoint bending at R = 0.1 following 100 hr. salt fog pitting corrosion. The results indicate that the improved fatigue life achieved with LPB after friction stir welding can be explained by delayed crack initiation and retardation of growth in the deep compressive layer produced by LPB. The fatigue crack growth analysis provides a theoretical basis for understanding the improved fatigue life realized with LPB and for estimating the residual stress distribution that will provide the highest achievable fatigue strength.
Tuning the microstructure of BaTiO3@SiO2 core-shell nanoparticles for high energy storage composite ceramics

Abstract Core-shell nanoparticles used as blocks to construct composite ceramics can exhibit high energy storage density, but the effects of original tunable shell thickness on the microstructures and energy storage property of finally sintered bulk ceramics has not been clarified, thus how to achieve the full potential of this technology to improve the energy storage density of ferroelectric-based ceramics remains to be solved. In this study, as precursors to fabricate bulk ceramics, BaTiO 3 @SiO 2 core-shell nanoparticles were successfully synthesized by a wet-chemical method and they were used as models to investigate the effect of the core-shell nanostructured precursors on the energy storage property of the bulk composite ceramics. The original BaTiO 3 nanoparticles coated with various homogenous SiO 2 shells were acquired by controlling the concentration of tetraethyl orthosilicate (TEOS). The surface microstructure of the bulk composite ceramics observed by scanning electron microscope (SEM) revealed that the SiO 2 outer shell of BaTiO 3 @SiO 2 nanoparticles plays an important role in constructing the microstructure of the ceramics. The remodeled microstructure has a great impact on leakage current density and dielectric property, and it makes a leading contribution to the energy storage performance of ceramics. As a result, the optimum SiO 2 loading range was confirmed and the maximum energy storage density obtained from BaTiO 3 @20 wt%SiO 2 was ∼4.799 J/cm 3 at 370 kV/cm, demonstrating that nanoscale core-shell architecture is an effective strategy to improve the energy storage performance of ferroelectric-based composite ceramics.
Efficacy of phase 1 trials in malignant pleural mesothelioma: description of a series of patients at a single institution.

BACKGROUND
Malignant pleural mesothelioma (MPM) is a locally aggressive disease with a poor prognosis. After failure of first line platinum-based chemotherapy, there is no widely approved salvage regimen. New strategies for treatment are needed and phase 1 trials appear as a rationale alternative.


MATERIALS AND METHODS
MPM patients were enrolled in 20 different phase 1 trials between March 2005 and January 2012, and their data analyzed retrospectively. The primary endpoint was response rate and secondary endpoints were toxicity profile, overall survival (OS) and progression free survival (PFS). OS and PFS were estimated using Kaplan-Meier and their association with baseline characteristics was investigated through a log-rank test. The drugs described were divided into 5 groups based on their mechanism of action.


RESULTS
Forty-five patients were analyzed with a median follow up of 20.5 months. The best tumor response was as follows: 4% of patients had a RECIST partial response, 60% had stable disease, 24% had progressive disease and 11% were not evaluable. Grade ≥3 toxicities were observed in 19 (42%) patients. Median OS and PFS were estimated to 6 months (95% CI=[4.2-10.5]) and 2 months (95% CI=[1.3-2.7]), respectively. The cellular motility inhibitors group appeared as the most promising class to be developed in a phase 2 setting.


CONCLUSION
Including MPM patients in phase I trials beyond first line of treatment can result in modest clinical benefits with an acceptable toxicity profile. Several molecular pathways involved in MPM have been identified and further novel biologic therapies need to be tested.
Anti-IL1 therapy in patients with refractory FMF living inGermany

Results Within our cohort of 160 adult patients with FMF, we identified 15 patients (4 female and 11 male) who were treated with anakinra (n=13) or canakinumab (n=2). Twelve of 15 patients (80%) were of turkish-armenian ancestry. The median FMF severity score was 8 (range 5-14). Patients carrying two high-penetrance MEFV mutations (M694V or M680I) had a severity score of 9 (8/15=53%). Patients with a single high penetrance mutation had a severity score of 11 (3/15=20%). Four patients (4/15=27%) had no MEFV mutations and the FMF severity score was 7.5 (p=0.2). FMF-related AA amyloidosis was diagnosed in 6 patients (40%) and the median FMF severity score was 10 compared to a severity score of 7 in 9 patients without amyloidosis (60%) (p=0.3). Anakinra was used continuously in 13 patients and in 2 patients only during attacks. The number of FMF attacks was significantly reduced by anti-IL1 treatment (p=0.0024). The patient reported health and the physician reported global health were both improved significantly (p
Skepticism And Cynicism In The Work Of Pedro De Valencia

This chapter is a contribution to the history of the reception of Hellenistic philosophy in late Renaissance and early modern Europe. Hellenistic philosophy consisted of several contending schools, of which the best known are the Stoics and Epicureans. One important scholar from late sixteenth and early seventeenth century Spain seems to have been as interested in ancient cynicism as he was in skepticism: Pedro de Valencia. Pedro de Valencia wrote his Academica in 1590 and it was printed in Antwerp in 1596 at the behest of some of his friends. Valencia's economic and political writings have been published in two volumes of the Complete Works . Valencia's work on cynicism consisted largely of translations and imitations of ancient cynical work on retirement from public life. Keywords: ancient skepticism; Greek cynicism; Pedro de Valencia