LLukas22/scidocs huggingface dataset:
Prognostic implications of abnormalities in renal function in patients with acute coronary syndromes.

BACKGROUND
Outcomes in patients with mild to moderate renal function (RF) abnormalities presenting with acute coronary syndromes (ACS) are not well defined.


METHODS AND RESULTS
A convenience sample of 4 ACS trial databases including all enrolled patients was assessed to determine 30- and 180-day outcomes. The 4 trials were Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) IIb, GUSTO-III, Platelet Glycoprotein IIb/IIIa in Unstable Angina: Receptor Suppression Using Integrilin Therapy (PURSUIT), and Platelet IIb/IIIa Antagonism for the Reduction of Acute coronary syndrome events in a Global Organization Network (PARAGON-A). Patients were stratified into ST-segment elevation (STE) and non-ST-segment elevation (NSE) groups and by the presence or absence of abnormal RF (creatinine clearance <70 mL/min). In the STE group, 7670 of 18 621 patients (41%) had abnormal RF. In the NSE group, 8152 of 19 304 (42%) had abnormal RF. Patients with abnormal RF were older, more often female, and more likely to have adverse baseline characteristics. They had higher mortality and higher mortality/nonfatal myocardial infarction (MI) at both 30 and 180 days, regardless of ST-segment status. Creatinine clearance was independently associated with risk of mortality (hazard ratio 0.79 in the STE group and 0.81 in the NSE group) and with risk of mortality/MI (hazard ratio 0.93) in the NSE group at 180 days.


CONCLUSIONS
Patients presenting with ACS frequently have abnormal RF. Abnormal RF is a marker of adverse baseline clinical characteristics and is independently associated with increased risk of death and death/MI.
Mirror, Mirror on my Facebook Wall: Effects of Exposure to Facebook on Self-Esteem

Contrasting hypotheses were posed to test the effect of Facebook exposure on self-esteem. Objective Self-Awareness (OSA) from social psychology and the Hyperpersonal Model from computer-mediated communication were used to argue that Facebook would either diminish or enhance self-esteem respectively. The results revealed that, in contrast to previous work on OSA, becoming self-aware by viewing one's own Facebook profile enhances self-esteem rather than diminishes it. Participants that updated their profiles and viewed their own profiles during the experiment also reported greater self-esteem, which lends additional support to the Hyperpersonal Model. These findings suggest that selective self-presentation in digital media, which leads to intensified relationship formation, also influences impressions of the self.
Differential equations with applications in cancer diseases.

UNLABELLED
Mathematical modeling is a process by which a real world problem is described by a mathematical formulation. The cancer modeling is a highly challenging problem at the frontier of applied mathematics. A variety of modeling strategies have been developed, each focusing on one or more aspects of cancer.


MATERIAL AND METHODS
The vast majority of mathematical models in cancer diseases biology are formulated in terms of differential equations. We propose an original mathematical model with small parameter for the interactions between these two cancer cell sub-populations and the mathematical model of a vascular tumor. We work on the assumption that, the quiescent cells' nutrient consumption is long. One the equations system includes small parameter epsilon. The smallness of epsilon is relative to the size of the solution domain.


RESULTS
MATLAB simulations obtained for transition rate from the quiescent cells' nutrient consumption is long, we show a similar asymptotic behavior for two solutions of the perturbed problem. In this system, the small parameter is an asymptotic variable, different from the independent variable. The graphical output for a mathematical model of a vascular tumor shows the differences in the evolution of the tumor populations of proliferating, quiescent and necrotic cells. The nutrient concentration decreases sharply through the viable rim and tends to a constant level in the core due to the nearly complete necrosis in this region.


CONCLUSIONS
Many mathematical models can be quantitatively characterized by ordinary differential equations or partial differential equations. The use of MATLAB in this article illustrates the important role of informatics in research in mathematical modeling. The study of avascular tumor growth cells is an exciting and important topic in cancer research and will profit considerably from theoretical input. Interpret these results to be a permanent collaboration between math's and medical oncologists.
Large Spin-Valley Polarization in Monolayer MoTe2 on Top of EuO(111).

The electronic properties of monolayer MoTe2 on top of EuO(111) are studied by first-principles calculations. Strong spin polarization is induced in MoTe2 , which results in a large valley polarization. In a longitudinal electric field this will result in a valley and spin-polarized charge Hall effect. The direction of the Hall current as well as the valley and spin polarizations can be tuned by an external magnetic field.
Genetic Analysis for Yield Potential and Quality Traits in Maize (Zea mays L.)

Abstract: Grain yield is a complex phenomenon which results from the interaction of various contributing factors highly influenced by environmental variation. Phenotypic selection cannot directly improve the characters in heterozygous crops like maize unless dissected by genetic analysis. Gene action for various quantitative and qualitative traits was explored in a complete set of diallel involving seven elite inbred lines. Variance/Co-variance graphs revealed that the yield potential traits like number of days taken to tasselling, number of days taken to silking, plant height, number of ears per plant, number of kernel rows per ear, number of kernels per row, 100-kernel weight and grain yield per plant were controlled by over dominance type of gene action, while quality traits like protein and oil contents were under the control of partial dominance with additive type of gene action.
The Joint Protection Behavior Assessment: a reliability study.

OBJECTIVE
Of the various measures developed for studying persons with rheumatoid arthritis, only one that focuses on joint protection has undergone extensive testing, the Joint Protection Behavior Assessment (JPBA). The purpose of the present study was to examine the interrater and intrarater reliability of the JPBA.


METHOD
Six healthy participants performed the JPBA under three test conditions (uninformed, informed, completely guided joint protection behavior). The 18 test performances were videotaped and scored by nine independent raters.


RESULTS
Analysis of these data showed that interrater reliability (intraclass correlation coefficient [ICC]) was .90 or higher, and intrarater reliability was .95 or higher (ICC). The correlation between the JPBA and its two shortened versions was .95 or higher (ICC). Internal consistency was also high, with a coefficient alpha of 0.95 for the complete JPBA. Kappa values showed that for most subtasks, there was fair to excellent agreement between raters and consistency of raters over time.


CONCLUSION
Our data suggest that the complete JPBA has excellent clinimetric properties and that the shortened versions are adequate for clinical situations. Some improvements in the test manual suggested by the present study may further improve the measure. A repeat of this study under real-world circumstances would provide an estimate of JPBA reliability in clinical practice.
Performance Analysis of RC5, Blowfish and DES Block Cipher Algorithms

In this paper, Performance analysis of RC5, Blowfish and DES block cipher algorithms have been done on the basis of execution time and resource utilization. CPU utilization and memory utilization both are considered for determining resource utilization. These three algorithms are parameterized algorithm and encrypt two w-bits at a time. Allowable choices for w are 16 bits, 32 bits, and 64 bits. Blowfish and DES have same structure for encryption and decryption while RC5 have different. RC5 has 12 and Blowfish & DES have 16 rounds. These three algorithms have a variable block size and a variable key size in their structure. Performances of RC5 & Blowfish algorithms have been evaluated on key size of 128-bits, 192-bit and 256-bit while key size is fixed 64-bit for DES in this paper.
Post-treatment outcomes in a double-blind, randomized trial of sertraline for alcohol dependence.

BACKGROUND
Pharmacotherapy studies in alcohol dependence (AD) are generally of short duration and do not include post-treatment follow-up. We examined the durability of treatment effects in a placebo-controlled trial of sertraline for AD.


METHODS
As previously reported, patients received 12 weeks of treatment with sertraline (n = 63) or placebo (n = 71), followed by assessments at 3 and 6 months post-treatment (Kranzler et al., 2011, J Clin Psychopharmacol 31:22-30). We examined the main and interaction effects with time of 3 between-subject factors (medication group, age of onset of AD [late-onset alcoholics, LOAs, vs. early-onset alcoholics, EOAs], and the tri-allelic 5-HTTLPR genotype) on drinking days (DDs) and heavy drinking days (HDDs).


RESULTS
The medication group effect, which was significant during treatment, remained significant during the 3-month follow-up period for L'/L' LOAs, with the sertraline group having fewer DDs than the placebo group (p = 0.027). However, the medication group effect seen in L'/L' EOAs during treatment was no longer significant (p = 0.48). There were no significant effects in S' carriers at the 3-month follow-up visit, or in either genotype group at the 6-month follow-up.


CONCLUSIONS
The beneficial effects of sertraline observed in LOAs during treatment persisted during the 3-month post-treatment period. Additional studies are needed to validate these pharmacogenetic findings, which together with the effects seen during active treatment support the use of sertraline only in LOAs.
Simulation and undergraduate engineering education: the technology reinvestment project (TRP)

This paper discusses an undergraduate engineering education program recently funded by the advanced research projects office (ARPA) technology reinvestment project (TRP) to add more hands-on experience for undergraduate engineering students.
Facial markers in second- and third-trimester fetuses with trisomy 18 or 13, triploidy or Turner syndrome.

OBJECTIVE
To examine the effectiveness of nasal bone (NB) evaluation (including NB length (NBL)), prenasal thickness (PT) measurement, the PT:NBL ratio and the prefrontal space ratio (PFSR) in the identification of fetuses with trisomy 18 or 13, triploidy or Turner syndrome.


METHODS
This was a retrospective study using stored midsagittal two-dimensional images of the facial profile of fetuses with trisomy 18 or 13, triploidy or Turner syndrome in the second and third trimesters. For images of acceptable quality, measurements were obtained of NBL (where NB was present), PT, the PT:NBL ratio and PFSR, and these measurements were compared with previously published normal ranges.


RESULTS
The search of databases identified 189 fetuses that met the study criteria: 132 (69.8%) with trisomy 18, 40 (21.2%) with trisomy 13, 10 (5.3%) with triploidy and seven (3.7%) with Turner syndrome. The NB was either absent or its measurement was below the 5(th) centile in 67 (50.8%), 20 (50.0%), five (50.0%) and two (28.6%) of the fetuses with trisomy 18, trisomy 13, triploidy and Turner syndrome, respectively. The PT measurement was above the 95(th) centile in 24 (18.2%), six (15.0%), one (10.0%) and one (14.3%) of the affected fetuses, respectively. The PFSR was abnormal in 72 (54.5%), 29 (72.5%), seven (70%) and four (57.1%) of the cases and the PT:NBL ratio was above the 95(th) centile or the nasal bone was absent in 72 (54.5%), 20 (50.0%), six (60.0%) and four (57.1%) cases, respectively.


CONCLUSION
Although each of the facial markers considered provides some useful information in screening for trisomy 18, trisomy 13, triploidy and Turner syndrome, the performance of none of the markers appears to be as good as that in screening for trisomy 21.
OPTIMIZED CLUSTERS FOR DISAGGREGATED ELECTRICITY LOAD FORECASTING

• To account for the variation of EDF’s (the French electrical company) portfolio following the liberalization of the electrical market, it is essential to disaggregate the global load curve. The idea is to disaggregate the global signal in such a way that the sum of disaggregated forecasts significantly improves the prediction of the whole global signal. The strategy is to optimize, a preliminary clustering of individual load curves with respect to a predictability index. The optimized clustering procedure is controlled by a forecasting performance via a cross-prediction dissimilarity index. It can be assimilated to a discrete gradient type algorithm. Key-Words: • clustering; disaggregation; forecasting; optimization; wavelets. AMS Subject Classification: • 62P30, 62H30, 62-07, 62M20. 106 Michel Misiti, Yves Misiti, Georges Oppenheim and Jean-Michel Poggi Optimized Clusters for Disaggregated Forecasting 107
On the Structure of Derivations in Deterministic ET0L Systems

Abstract This paper investigates the structure of derivations in deterministic ET0L systems. The main theorem says that in a deterministic ETOL system each derivation of a long enough word of a special kind (the so-called f -random word) has a rather strong combinatorial structure. In fact the main result of this paper is essential for proving some useful properties of ET0L languages which is demonstrated in a number of papers.
Research on gain scheduling

Current research on gain scheduling is clarifying customary practices as well as devising new approaches and methods for the design of nonlinear control systems. Abstract Gain scheduling for nonlinear controller design is described in terms of general features of the approach and in terms of early examples of applications in #ight control and automotive engine control. Then recent research is discussed, emphasizing work on linearization-based scheduling and work on linear parameter-varying approaches. 2000 Elsevier Science Ltd. All rights reserved.
A Uniformly Distributed Adaptive Clustering Hierarchy Routing Protocol

Energy efficiency is one of the most important considerations in wireless sensor networks. In a clustered sensor network, some of the nodes become cluster heads. They aggregate the data from their cluster members and transmit it to the base station. In this paper, we propose a uniformly distributed adaptive clustering hierarchy routing protocol (UDACH). Unlike LEACH and LEACH-C, our protocol is based on energy equilibrium instead of choosing cluster heads randomly. We divide the protocol into three stages: cluster construction, building a cluster head tree, and sending data. In cluster construction stage, cluster heads are elected and each node identifies its cluster head. In the stage of building a cluster head tree, the tree is created based on the weight of each cluster head. And the weight is inversely proportional to the distance from the base station to the node. In the last stage, each cluster member collects the data and sends it to the base station by its cluster head. Our proposed protocol is simulated and compared with LEACH and LEACH-C. The simulation result shows that UDACH has better performance in network lifetime and energy expense than LEACH and LEACH-C.
STOPP/START criteria for potentially inappropriate prescribing in older people: version 2

PURPOSE
Screening tool of older people's prescriptions (STOPP) and screening tool to alert to right treatment (START) criteria were first published in 2008. Due to an expanding therapeutics evidence base, updating of the criteria was required.


METHODS
We reviewed the 2008 STOPP/START criteria to add new evidence-based criteria and remove any obsolete criteria. A thorough literature review was performed to reassess the evidence base of the 2008 criteria and the proposed new criteria. Nineteen experts from 13 European countries reviewed a new draft of STOPP & START criteria including proposed new criteria. These experts were also asked to propose additional criteria they considered important to include in the revised STOPP & START criteria and to highlight any criteria from the 2008 list they considered less important or lacking an evidence base. The revised list of criteria was then validated using the Delphi consensus methodology.


RESULTS
The expert panel agreed a final list of 114 criteria after two Delphi validation rounds, i.e. 80 STOPP criteria and 34 START criteria. This represents an overall 31% increase in STOPP/START criteria compared with version 1. Several new STOPP categories were created in version 2, namely antiplatelet/anticoagulant drugs, drugs affecting, or affected by, renal function and drugs that increase anticholinergic burden; new START categories include urogenital system drugs, analgesics and vaccines.


CONCLUSION
STOPP/START version 2 criteria have been expanded and updated for the purpose of minimizing inappropriate prescribing in older people. These criteria are based on an up-to-date literature review and consensus validation among a European panel of experts.
Comparing Static Security Analysis Tools Using Open Source Software

Software vulnerabilities present a significant impediment to the safe operation of many computer applications, both proprietary and open source. Fortunately, many static analysis tools exist to identify potential security issues. We present the results of evaluating multiple subsets of open source code for common software vulnerabilities using several such static security analysis tools. These results aid other developers in better discerning which tools to use in evaluating their own programs for security vulnerabilities.
The Cross-Entropy Method for Optimization

The cross-entropy method is a versatile heuristic tool for solving difficult estimation and optimization problems, based on Kullback–Leibler (or cross-entropy) minimization. As an optimization method it unifies many existing populationbased optimization heuristics. In this chapter we show how the cross-entropy method can be applied to a diverse range of combinatorial, continuous, and noisy optimization problems.
Procedures for an instrument development study: the Botswana experience.

BACKGROUND
Health protective sexual communication (HPSC) between sexual partners can contribute to human immunodeficiency virus (HIV) prevention, but women face difficulties with HPSC because of cultural and gender issues.


PURPOSE
To present the procedures for an instrument development study conducted in Botswana between 2006 and 2008 on different aspects of HPSC. The study was guided by the theory of planned behaviour constructs.


METHODS
A literature review and a qualitative pilot study among young women aged 18-35 years in Gaborone city clinics generated items for the measures. Eleven measures were developed and evaluated for content validity. The measures were translated and evaluated by three typical participants for cultural relevance and acceptance. A quantitative pilot among ten women and a larger quantitative study among 280 other young women followed in 13 Gaborone city clinics for internal consistency reliability, and construct validity based on principal components analysis. All women who met selection criteria consented and responded to all questions. Research protocols were strictly adhered to.


RESULTS
Eight measures were reliable, with Cronbach's alphas between 0.69 and 0.95. Underlying factors were extracted for these. Two measures were unreliable, one with spuriously low reliability due to its brevity. Some significant relationships were identified between measures. DISCUSSION OF FINDINGS: The results highlighted the importance of HPSC, the significant influence of the male sexual partners and other relatives, and the need to integrate HPSC at all levels of HIV/acquired immunodeficiency syndrome prevention and research, focusing on the effectiveness of HPSC.
Individual and social benefits of online discussion forums

There has been much debate surrounding the potential benefits and costs of online interaction. The present research argues that engagement with online discussion forums can have underappreciated benefits for users’ well-being and engagement in offline civic action, and that identification with other online forum users plays a key role in this regard. Users of a variety of online discussion forums participated in this study. We hypothesized and found that participants who felt their expectations had been exceeded by the forum reported higher levels of forum identification. Identification, in turn, predicted their satisfaction with life and involvement in offline civic activities. Formal analyses confirmed that identification served as a mediator for both of these outcomes. Importantly, whether the forum concerned a stigmatized topic moderated certain of these relationships. Findings are discussed in the context of theoretical and applied implications. 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http:// creativecommons.org/licenses/by/4.0/).
Associations of Coffee Drinking with Systemic Immune and Inflammatory Markers.

BACKGROUND
Coffee drinking has been inversely associated with mortality as well as cancers of the endometrium, colon, skin, prostate, and liver. Improved insulin sensitivity and reduced inflammation are among the hypothesized mechanisms by which coffee drinking may affect cancer risk; however, associations between coffee drinking and systemic levels of immune and inflammatory markers have not been well characterized.


METHODS
We used Luminex bead-based assays to measure serum levels of 77 immune and inflammatory markers in 1,728 older non-Hispanic Whites. Usual coffee intake was self-reported using a food frequency questionnaire. We used weighted multivariable logistic regression models to examine associations between coffee and dichotomized marker levels. We conducted statistical trend tests by modeling the median value of each coffee category and applied a 20% false discovery rate criterion to P values.


RESULTS
Ten of the 77 markers were nominally associated (P trend < 0.05) with coffee drinking. Five markers withstood correction for multiple comparisons and included aspects of the host response namely chemotaxis of monocytes/macrophages (IFNγ, CX3CL1/fractalkine, CCL4/MIP-1β), proinflammatory cytokines (sTNFRII), and regulators of cell growth (FGF-2). Heavy coffee drinkers had lower circulating levels of IFNγ [odds ratios (OR), 0.35; 95% confidence intervals (CI), 0.16-0.75], CX3CL1/fractalkine (OR, 0.25; 95% CI, 0.10-0.64), CCL4/MIP-1β (OR, 0.48; 95% CI, 0.24-0.99), FGF-2 (OR, 0.62; 95% CI, 0.28-1.38), and sTNFRII (OR, 0.34; 95% CI, 0.15-0.79) than non-coffee drinkers.


CONCLUSIONS
Lower circulating levels of inflammatory markers among coffee drinkers may partially mediate previously observed associations of coffee with cancer and other chronic diseases.


IMPACT
Validation studies, ideally controlled feeding trials, are needed to confirm these associations.
Securing Smart Cities Using Blockchain Technology

A smart city uses information technology to integrate and manage physical, social, and business infrastructures in order to provide better services to its dwellers while ensuring efficient and optimal utilization of available resources. With the proliferation of technologies such as Internet of Things (IoT), cloud computing, and interconnected networks, smart cities can deliver innovative solutions and more direct interaction and collaboration between citizens and the local government. Despite a number of potential benefits, digital disruption poses many challenges related to information security and privacy. This paper proposes a security framework that integrates the blockchain technology with smart devices to provide a secure communication platform in a smart city.