LLukas22/scidocs huggingface dataset:
The Rapp–Hodgkin syndrome results from mutations of the TP63 gene

The Rapp–Hodgkin syndrome (RHS, MIM 129400) corresponds to a rare form of anhydrotic ectodermal dysplasia, which shares some features with the ectrodactyly, ectodermal dysplasia and cleft lip/palate syndrome (EEC, MIM 604292) resulting from TP63 mutations. We report here, in two unrelated patients with RHS, the identification of two distinct TP63 mutations, corresponding to a novel frameshift mutation (1709DelA, exon 14) located downstream the sterile alpha motif (SAM) domain and to a missense mutation (R279H, exon 7) within the DNA binding domain. Functional analysis of the R279H mutation, which had previously been reported in several EEC families, shows that this mutation disrupted the dominant negative activity of the ΔNp63α and γ isoforms on the transcriptional activity of TP53. This report shows, on a molecular basis, that RHS is also an EEC-like syndrome resulting from mutations of the TP63 gene, and highlights the wide phenotypic spectrum associated to TP63 mutations.
Voluntary activation level and muscle fiber recruitment of human quadriceps during lengthening contractions.

Voluntary activation levels during lengthening, isometric, and shortening contractions (angular velocity 60 degrees/s) were investigated by using electrical stimulation of the femoral nerve (triplet, 300 Hz) superimposed on maximal efforts. Recruitment of fiber populations was investigated by using the phosphocreatine-to-creatine ratio (PCr/Cr) of single characterized muscle fibers obtained from needle biopsies at rest and immediately after a series of 10 lengthening, isometric, and shortening contractions (1 s on/1 s off). Maximal voluntary torque was significantly higher during lengthening (270 +/- 55 N.m) compared with shortening contractions (199 +/- 47 N.m, P < 0.05) but was not different from isometric contractions (252 +/- 47 N.m). Isometric torque was higher than torque during shortening (P < 0.05). Voluntary activation level during maximal attempted lengthening contractions (79 +/- 8%) was significantly lower compared with isometric (93 +/- 5%) and shortening contractions (92 +/- 3%, P < 0.05). Mean PCr/Cr values of all fibers from all subjects at rest were 2.5 +/- 0.6, 2.0 +/- 0.7, and 2.0 +/- 0.7, respectively, for type I, IIa, and IIax fibers. After 10 contractions, the mean PCr/Cr values for grouped fiber populations (regardless of fiber type) were all significantly different from rest (1.3 +/- 0.2, 0.7 +/- 0.3, and 0.8 +/- 0.6 for lengthening, isometric, and shortening contractions, respectively; P < 0.05). The cumulative distributions of individual fiber populations after either contraction mode were significantly different from rest (P < 0.05). Curves after lengthening contractions were less shifted compared with curves from isometric and shortening contractions (P < 0.05), with a smaller shift for the type IIax compared with type I fibers in the lengthening contractions. The results indicate a reduced voluntary drive during lengthening contractions. PCr/Cr values of single fibers indicated a hierarchical order of recruitment of all fiber populations during maximal attempted lengthening contractions.
Factors associated with sustained attention during an activity intervention in persons with dementia.

BACKGROUND/AIMS
Are the noncognitive factors of self-reported mood and personality related to sustained attention in nursing home residents with dementia during an activity intervention?


METHODS
Intervention data from a randomized clinical trial were used to address the aim of this project. Subjects were 128 nursing home residents who were assessed for mood, personality, behavioral indicators of attention, time on task and number of disengagements during an activity intervention.


RESULTS
More positive self-reported mood was associated with greater behavioral displays of attention during activities, greater time spent engaged in the activities and less disengagement.


CONCLUSION
To our knowledge, this is the first study to report on the association of mood, personality and sustained attention in nursing home residents with dementia. While the findings are preliminary, they can be used to inform the design of future research.
ASSOCIATE NURSING STUDENTS' PERCEPTIONS TOWARD NURSING PROFESSION IN JORDAN

The image of both nurses and nursing as a profession are vital in the successful recruitment and retention of staff in the health care industry (Annelie Meiring, 2010). This study design to overview the image of nursing among associate nursing students in south Jordan. The study was conducted on Balqa Applied University, Jordan, Karak and Aqaba college branches, Faculty of Nursing for student enrolled in associate nursing program. Three main parts were selected, profession view, dependent and independent order of work and personal growth. The data collected through self-administered questionnaire containing three major parts: The first part is the sociodemographic characteristics; the second part is image of nursing; the third part is social rank of job. The study involved a randomly selected 100 students from both sites,68 questionnaires were analyzed by (SPSS)15. Descriptive Statistics were done using numbers, percentage, arithmetic mean ,standered deviation and one sample test. The study showed that the associate nursing students generally have a significance positive perceptions about the image of the nursing profession. The highest percentage of study subjects joined the faculty of nursing because of financial reasons/ availability of work. Majority of the students feel proud when talking with others about nursing profession. The relationship with medical members and the family member opinion have the greatest effect in changing the image of nursing profession. This study concluded that a majority of the respondents preferred teaching institution and bedside nursing after the graduation.
A Lower Bound on the Complexity of Approximate Nearest-Neighbor Searching on the Hamming Cube

We consider the nearest-neighbor problem over the d-cube: given a collection of points in {0, l}d, find the one nearest to a query point (in the L’ sense). We establish a lower bound of n(log log dl log log log d) on the worst-case query time. This result holds in the cell probe model with (any amount of) polynomial storage and word-size do(‘). The same lower bound holds for the approximate version of the problem, where the answer may be any point further than the nearest neighbor by a factor as large as 2L(‘ogd)‘-‘~, for any fixed E > 0.
Healthcare costs in the Danish randomised controlled lung cancer CT-screening trial: a registry study.

OBJECTIVES
Low dose computerised tomography (CT) screening for lung cancer can reduce lung-cancer-specific mortality. The objective of this study was to analyse healthcare costs and healthcare utilisation of participants in the Danish lung cancer CT-screening trial (DLCST).


MATERIALS AND METHODS
This registry study was nested in a randomised controlled trial (DLCST). 4104 participants, current or former heavy smokers, aged 50-70 years were randomised to five annual low dose CT scans or usual care during 2004-2010. Total healthcare costs and healthcare utilisation data for both the primary and the secondary healthcare sector were retrieved from public registries from randomisation - September 2011 and compared between (1) the CT-screening group and the control group and, (2) the control group and each of the true-positive, false-positive and true-negative groups.


RESULTS
The median annual costs per participant were significantly higher in the CT-screening group (Euros [EUR] 1342, interquartile range [IQR] 750-2980) compared with the control group (EUR 1190, IQR 590-2692) (p<0.0001). When the cost of the CT-screening programme was excluded, there was no longer a statistically significant difference between the CT-screening group (EUR 1155, IQR 567-2798) and the control group (p=0.52). Analyses according to the diagnostic groups showed that annual costs were 10.57 (95% CI 7.09-15.75) times higher for the true-positive and 1.67 (95% CI 1.20-2.32) times higher for the false-positive group compared with the control group.


CONCLUSION
Low dose lung cancer CT screening increases healthcare costs compared with no screening; this difference was attributable to the costs of the CT-screening programme. Overall healthcare costs were higher for the true-positive and false-positive groups than for the control group, also when excluding the cost of the CT-screening programme. This increase was outweighed by the larger true-negative group showing no significant differences in costs compared with the control group.
Comparison of RBFN based STATCOM, SSSC and UPFC Controllers for Transient Stability improvement

This paper presents the comparative performance of radial basis function network (RBFN) controlled voltage source converters (VSC) based flexible AC transmission system (FACTS) devices, such as static synchronous compensator (STATCOM), static synchronous series compensator (SSSC) and unified power flow controller (UPFC) in terms of increase in power handling capacity of the line, improvements in transient stability and damping of oscillations in the single machine infinite bus system (SMIB and multimachine system. The PI & radial basis function network (RBFN) based controllers are designed to coordinate local measurable control inputs to FACTS devices. The damping schemes namely, (i) power oscillation damping (POD) control, and (ii) conventional power system stabilizer (PSS) are tuned to coordinate with proposed RBFN controller. The coordinated action of POD & PSS are included in simulation. The results indicate that the proposed intelligent controllers are capable of exploring advantageous feature of FACTS devices
Social cognition and quality of life in schizophrenia

Schizophrenia is associated with poor quality of life (QOL). Whereas the effects of neurocognitive deficits and psychopathology on QOL of schizophrenia patients have recently been elucidated, little is known about social cognitive deficits in this regard. This study investigated the influence of social cognition on QOL in schizophrenia. A sample of 1032 patients, 1011 of their siblings, and 552 healthy controls was recruited from the Dutch Genetic Risk and Outcome in Psychosis (GROUP) study. Participants completed a battery of cognitive tests, including social cognitive tests on theory of mind and emotion perception. To assess QOL the World Health Organization QOL Assessment-BREF (WHOQOL-BREF) was used. Schizophrenia symptoms were assessed with the Positive and Negative Syndrome Scale (PANSS). Social cognitive performance was significantly worse in patients compared to siblings and healthy controls. Patients had the poorest QOL, while QOL in healthy controls was better than in siblings. Theory of mind but not emotion perception or neurocognition was associated with QOL in patients, whereas neurocognition was the only significant predictor of QOL in siblings and healthy controls. There was a significant interaction between theory of mind and symptom severity with respect to QOL. Our study indicates that social cognition is associated with QOL in schizophrenia. Theory of mind rather than emotion perception is associated with QOL, and this association is moderated by schizophrenia symptoms. In particular, patients with relatively unimpaired theory of mind and more severe schizophrenia symptoms have poor QOL and could therefore benefit from therapeutic intervention.
The Stability of Pregnancy Intentions and Pregnancy-Related Maternal Behaviors

Objectives: Our objectives were to characterize the stability of pregnancy intention and to examine whether stability is associated with the timing of prenatal care initiation, smoking during pregnancy, and breastfeeding. Methods: We use a sample of women from the National Longitudinal Survey of Youth (NLSY) for whom information on pregnancy intention was collected both during pregnancy and after delivery. In bivariate analyses we compare outcomes and characteristics of women whose pregnancy intention changed between the prenatal and postpartum periods. With multivariate methods, we analyze the correlates of switching pregnancy intention as well as the association between switching and maternal behaviors. Results: Women whose pregnancy intention changes between the two assessments are similar in marital status and socioeconomic background to those who report both during pregnancy and after delivery that the pregnancy is unintended. Disagreement during pregnancy between the parents' pregnancy intentions is the most important predictor of instability in the mother's pregnancy intention. Effects of unintended pregnancy on the timing of initiation of prenatal care, smoking during pregnancy, and breastfeeding based on reports after delivery are smaller than those based on reports during pregnancy, although differences are not statistically significant. Adverse effects of unintended pregnancy are greater when pregnancies reported by the mother to be unintended at either assessment are combined into a single category for unintended pregnancy. Conclusion: Unstable pregnancy intention may be a marker for adverse maternal behaviors related to infant health.
Ensuring valid measurements for a disabled population: an insulin pen pilot study.

Corresponding Author: Ann S. Williams, Ph.D., R.N., C.D.E., Frances Payne Bolton School of Nursing, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106; email address ann.s.williams@case.edu Health promotion and self-management for persons with disabilities have been severely underemphasized in health care research. As researchers seek to fill these gaps in knowledge, it is essential that they validate their methods through use of pilot studies. The following pilot study illustrates how such exploration can lead to unexpected and necessary modification of methods.
High temperature tolerance in chickpea and its implications for plant improvement

Chickpea (Cicer arietinum L.) is an important food legume and heat stress affects chickpea ontogeny over a range of environments. Generally, chickpea adapts to high temperature through an escape mechanism. However, heat stress during
Unified Array Manifold Decomposition Based on Spherical Harmonics and 2-D Fourier Basis

In this paper, we derive a unified framework for orthonormal decomposition of the array manifold on scalar fields. Such fields are encountered in cases where polarization is not considered, e.g., single polarized radio waves and acoustic pressure. The results generalize and unify different decompositions of the array manifold, found in recent literature, to arrays of arbitrary geometry including conformal arrays. The concept of equivalence matrix is introduced, establishing a link between the spherical harmonics and 2-D Fourier basis functions. Under some mild assumptions that typically hold in practice, a one-to-one relationship between spherical harmonic spectra and 2-D Fourier spectra may be established. Additionally, it is shown that the rows of the equivalence matrix and the 2-D Fourier spectra of the array manifold span the same subspace. With such results the spherical harmonic and 2-D Fourier decompositions of the array manifold vector, i.e., Wavefield Modeling and 2-D Effective Aperture Distribution Function (EADF) are shown to be equivalent. Results on the modeling capabilities of both orthonormal decompositions are obtained. Moreover, the equivalence matrix is shown to facilitate noise attenuation. A fast spherical harmonic transform with complexity O(Q logQ) can be obtained by exploiting the equivalence matrix, where Q represents the total number of points on the sphere. Finally, the equivalence matrix allows to gain more insight into the relation between rotating a function on the sphere and on the torus. These contributions facilitate high-resolution array processing both in elevation and azimuth irrespective of the array structure or imperfections.
Computing optimal or near-optimal trees for minimum-energy in wireless networks

We study minimum-energy broadcast routing in all-wireless networks. Up to now, a number of heuristics have been proposed for this NP-hard problem. Among them, the broadcast incremental power (BIP) algorithm, presented by Wieselthier et al., is most known. The contribution of our work consists of a refinement of the BIP algorithm and a novel integer programming formulation. The refined version of BIP is a natural extension of the original algorithm. The integer programming formulation allows us to compute optimal broadcast trees for networks of small size. For large-sized networks, the formulation admits the computation of a sharp lower bound to the optimal tree. We are thus able to efficiently assess the numerical performance of any heuristic algorithm for the problem. In our computational study, we compare the performance of our refined BlP algorithm to that of its original version, and examine the numerical performance of the two algorithms in terms of optimality using our integer programming model.
Mining frequent subgraphs over uncertain graph databases under probabilistic semantics

Frequent subgraph mining has been extensively studied on certain graph data. However, uncertainty is intrinsic in graph data in practice, but there is very few work on mining uncertain graph data. This paper focuses on mining frequent subgraphs over uncertain graph data under the probabilistic semantics. Specifically, a measure called $${\varphi}$$ -frequent probability is introduced to evaluate the degree of recurrence of subgraphs. Given a set of uncertain graphs and two real numbers $${0 < \varphi, \tau < 1}$$ , the goal is to quickly find all subgraphs with $${\varphi}$$ -frequent probability at least τ. Due to the NP-hardness of the problem and to the #P-hardness of computing the $${\varphi}$$ -frequent probability of a subgraph, an approximate mining algorithm is proposed to produce an $${(\varepsilon, \delta)}$$ -approximate set Π of “frequent subgraphs”, where $${0 < \varepsilon < \tau}$$ is error tolerance, and 0 < δ < 1 is a confidence bound. The algorithm guarantees that (1) any frequent subgraph S is contained in Π with probability at least ((1 − δ) /2) s , where s is the number of edges in S; (2) any infrequent subgraph with $${\varphi}$$ -frequent probability less than $${\tau - \varepsilon}$$ is contained in Π with probability at most δ/2. The theoretical analysis shows that to obtain any frequent subgraph with probability at least 1 − Δ, the input parameter δ of the algorithm must be set to at most $${1 - 2 (1 - \Delta)^{1 / \ell_{\max}}}$$ , where 0 < Δ < 1, and ℓ max is the maximum number of edges in frequent subgraphs. Extensive experiments on real uncertain graph data verify that the proposed algorithm is practically efficient and has very high approximation quality. Moreover, the difference between the probabilistic semantics and the expected semantics on mining frequent subgraphs over uncertain graph data has been discussed in this paper for the first time.
Branding a B 2 B service : Does a brand differentiate a logistics service provider ? ☆

Existing research has shown that strong brands serve as an important point of differentiation for firms, assisting customers in their evaluation and choice processes. Although there is considerable research on the branding of consumer goods and an increasing literature on industrial and service brands, little is known about branding in the context of business-to-business services. This research extends existing brand theory to a new setting, namely B2B services. Drawing on the results of two mail surveys, we examine B2B services branding in the context of logistics services. Findings suggest that brands do differentiate the offerings of logistics service providers and that brand equity exists for this commodity-like B2B service. Findings also support the extendibility of Keller's [Keller, K. L. (1993). Conceptualizing, measuring, and managing customer-based brand equity. Journal of Marketing, 57(1), 1–22] brand equity framework into the logistics services context. However, results of this study show that; logistics service providers and their customers have different perspectives on the relative influence of brand image and brand awareness on brand equity. Implications of these findings for managers and directions for future research are offered. © 2007 Elsevier Inc. All rights reserved.
A DOUBLE-DIF ERENTIAL-INPUT / DIF ERENTIAL-OUTPUT FUL Y COMPLEMENTARY AND SELF-BIASED ASYNCHRONOUS CMOS COMPARATOR

Abstract: A novel fully complementary and fully differential asynchronous CMOS comparator architecture, that consists of a two-stage preamplifier cascaded with a latch, achieves a sub-100 ps propagation delay for a 50mVpp and higher input signal amplitudes under 1.1V supply and 2.1mW power consumption. The proposed voltage comparator topology features two differential pairs of inputs (four in total) thus increasing signal-to-noise ratio (SNR) and noise immunity through rejection of the coupled noise components, reduced evenorder harmonic distortion, and doubled output voltage swing. In addition to that, the comparator is truly self-biased via negative feedback loop thereby eliminating the need for a voltage reference and suppressing the influence of process, supply voltage and ambient temperature variations. The described analog comparator prototype occupies 0.001mm in a purely digital 40 nm LP (low power) CMOS process technology. All the above mentioned merits make it highly attractive for use as a building block in implementation of the leadingedge system-on-chip (SoC) data transceivers and data converters.
Electromagnetic brain mapping - IEEE Signal Processing Magazine

seen tremendous advances in our ability to produce images of human brain function. Applications of functional brain imaging extend from improving our understanding of the basic mechanisms of cognitive processes to better characterization of pathologies that impair normal function. Magnetoencephalography (MEG) and electroencephalography (EEG) (MEG/EEG) localize neural electrical activity using noninvasive measurements of external electromagnetic signals. Among the available functional imaging techniques, MEG and EEG uniquely have temporal resolutions below 100 ms. This temporal precision allows us to explore the timing of basic neural processes at the level of cell assemblies. MEG/EEG source localization draws on a wide range of signal processing techniques including digital filtering, three-dimensional image analysis, array signal processing, image modeling and reconstruction, and, more recently, blind source separation and phase synchrony estimation. In this article we describe the underlying models currently used in MEG/EEG source estimation and describe the various signal processing steps required to compute these sources. In particular we describe methods for computing the forward fields for known source distributions and parametric and imaging-based approaches to the inverse problem. Introduction Functional brain imaging is a relatively new and multidisciplinary research field that encompasses techniques devoted to a better understanding of the human brain through noninvasive imaging of the electrophysiological, hemodynamic, metabolic, and neurochemical processes that underlie normal and pathological brain