LLukas22/scidocs huggingface dataset:
MR Angiography at 3 T of Peripheral Arterial Disease: A Randomized Prospective Comparison of Gadoterate Meglumine and Gadobutrol.

OBJECTIVE
This large-scale randomized study aimed to show the noninferiority in terms of diagnostic performance of gadoterate meglumine-enhanced versus gadobutrol-enhanced 3-T MR angiography (MRA) using digital subtraction angiography (DSA) as the reference standard in patients with peripheral arterial occlusive disease (PAOD).


SUBJECTS AND METHODS
In this prospective international randomized double-blind phase IV trial, 189 patients were enrolled. Of them, 156 could be included in the per-protocol population for on-site assessments and 154 for off-site readings. Subjects underwent peripheral MRA, after injection of 0.1 mmol/kg of either gadoterate meglumine or gadobutrol, and DSA within 30 days. The diagnostic accuracy was evaluated and compared using a noninferiority analysis. Secondary endpoints included sensitivity, specificity, diagnostic confidence, contrast-to-noise ratio, and signal-to-noise ratio evaluations.


RESULTS
The percentage agreement between MRA and DSA for stenosis detection was similar for on-site readings for both groups (mean ± SD, 80.6% ± 16.1% with gadoterate meglumine vs 77.1% ± 19.6% with gadobutrol; 3.5% difference), and the same was true for off-site readings (73.9% ± 16.9% with gadoterate meglumine vs 75.1% ± 13.8% with gadobutrol; 1.1% difference). The noninferiority of gadoterate meglumine to gadobutrol was shown for both on- and off-site readings. Sensitivity in detecting significant stenosis (> 50%) was 72.3% for gadoterate meglumine versus 70.6% for gadobutrol, whereas specificity (92.6% vs 92.3%), diagnostic confidence (87.0% vs 86.0%), signal-to-noise ratio (165.5 vs 161.0), and contrast-to-noise ratio (159.5 vs 155.3) did not differ statistically significantly between the two groups.


CONCLUSION
Gadoterate meglumine was found to be not inferior to gadobutrol in terms of diagnostic performance in patients with PAOD undergoing 3-T contrast-enhanced MRA. No statistically significant differences were detected between the two MRA groups.
How to Generate a Good Word Embedding

The authors analyze three critical components in training word embeddings: model, corpus, and training parameters. They systematize existing neural-network-based word embedding methods and experimentally compare them using the same corpus. They then evaluate each word embedding in three ways: analyzing its semantic properties, using it as a feature for supervised tasks, and using it to initialize neural networks. They also provide several simple guidelines for training good word embeddings.
Poincar\'e invariant quantum theory, J. Lab lectures

Lectures on Poincare invariant quantum theory presented at TJNAF.
Efficient Eye Blink Detection Method for disabled- helping domain

In this paper, we present a real time method based on some video and image processing algorithms for eye blink detection. The motivation of this research is the need of disabling who cannot control the calls with human mobile interaction directly without the need of hands. A Haar Cascade Classifier is applied for face and eye detection for getting eye and facial axis information. In addition, the same classifier is used based on Haarlike features to find out the relationship between the eyes and the facial axis for positioning the eyes. An efficient eye tracking method is proposed which uses the position of detected face. Finally, an eye blinking detection based on eyelids state (close or open) is used for controlling android mobile phones. The method is used with and without smoothing filter to show the improvement of detection accuracy. The application is used in real time for studying the effect of light and distance between the eyes and the mobile device in order to evaluate the accuracy detection and overall accuracy of the system. Test results show that our proposed method provides a 98% overall accuracy and 100% detection accuracy for a distance of 35 cm and an artificial light. Keywords—eye detection; eye tracking; eye blinking; smoothing filter; detection accuracy
Fair trade, corporate accountability and beyond: Experiments in globalizing justic [Book Review]

Review(s) of: Fair trade, corporate accountability and beyond: Experiments in globalizing justic, by Kate Macdonald and Shelley Marshall, Ashgate, Farnham, 2010.
STRATEGIC MAP FOR HOSPITAL MANAGEMENT: PERSPECTIVES AND PRIORITIES

The aim of this article is to present the application of a strategic map for hospital management. The main hypothesis is, that strategic map for a hospital should differ from the classical one by Kaplan & Norton due to different priorities hospital work specificity as such. The main finding is that financial perspective is fundamental, basic for hospital activity. In hospital “X” strategic map, finance are the resource, not the result. Received: December, 2015 1st Revision: March, 2016 Accepted: June, 2016 DOI: 10.14254/2071789X.2016/9-3/6 JEL Classification: I11, M41, M21
NoiseTube: Measuring and mapping noise pollution with mobile phones

In this paper we present a new approach for the assessment of noise pollution involving the general public. The goal of this project is to turn GPS-equipped mobile phones into noise sensors that enable citizens to measure their personal exposure to noise in their everyday environment. Thus each user can contribute by sharing their geo-localised measurements and further personal annotation to produce a collective noise map.
Adaptive Prediction Error Coding in the Human Midbrain and Striatum Facilitates Behavioral Adaptation and Learning Efficiency

Effective error-driven learning benefits from scaling of prediction errors to reward variability. Such behavioral adaptation may be facilitated by neurons coding prediction errors relative to the standard deviation (SD) of reward distributions. To investigate this hypothesis, we required participants to predict the magnitude of upcoming reward drawn from distributions with different SDs. After each prediction, participants received a reward, yielding trial-by-trial prediction errors. In line with the notion of adaptive coding, BOLD response slopes in the Substantia Nigra/Ventral Tegmental Area (SN/VTA) and ventral striatum were steeper for prediction errors occurring in distributions with smaller SDs. SN/VTA adaptation was not instantaneous but developed across trials. Adaptive prediction error coding was paralleled by behavioral adaptation, as reflected by SD-dependent changes in learning rate. Crucially, increased SN/VTA and ventral striatal adaptation was related to improved task performance. These results suggest that adaptive coding facilitates behavioral adaptation and supports efficient learning.
Comparison of Immediate With Delayed Stenting Using the Minimalist Immediate Mechanical Intervention Approach in Acute ST-Segment-Elevation Myocardial Infarction: The MIMI Study.

BACKGROUND
Delayed stent implantation after restoration of normal epicardial flow by a minimalist immediate mechanical intervention aims to decrease the rate of distal embolization and impaired myocardial reperfusion after percutaneous coronary intervention. We sought to confirm whether a delayed stenting (DS) approach (24-48 hours) improves myocardial reperfusion, versus immediate stenting, in patients with acute ST-segment-elevation myocardial infarction undergoing primary percutaneous coronary intervention.


METHODS AND RESULTS
In the prospective, randomized, open-label minimalist immediate mechanical intervention (MIMI) trial, patients (n=140) with ST-segment-elevation myocardial infarction ≤12 hours were randomized to immediate stenting (n=73) or DS (n=67) after Thrombolysis In Myocardial Infarction 3 flow restoration by thrombus aspiration. Patients in the DS group underwent a second coronary arteriography for stent implantation a median of 36 hours (interquartile range 29-46) after randomization. The primary end point was microvascular obstruction (% left ventricular mass) on cardiac magnetic resonance imaging performed 5 days (interquartile range 4-6) after the first procedure. There was a nonsignificant trend toward lower microvascular obstruction in the immediate stenting group compared with DS group (1.88% versus 3.96%; P=0.051), which became significant after adjustment for the area at risk (P=0.049). Median infarct weight, left ventricular ejection fraction, and infarct size did not differ between groups. No difference in 6-month outcomes was apparent for the rate of major cardiovascular and cerebral events.


CONCLUSIONS
The present findings do not support a strategy of DS versus immediate stenting in patients with ST-segment-elevation infarction undergoing primary percutaneous coronary intervention and even suggested a deleterious effect of DS on microvascular obstruction size.


CLINICAL TRIAL REGISTRATION
URL: http://www.clinicaltrials.gov. Unique identifier: NCT01360242.
Smart Products: An Introduction

Sophisticated commercial products and product assemblies can greatly benefit from novel IT-based approaches to the conditioning of these products and of „product knowledge‟, leading to what we call Smart Products. The paper motivates the need for such novel approaches, introduces important relevant challenges and research domains, and provides an early definition of Smart Products.
Does it matter which exercise? A randomized control trial of exercise for low back pain.

STUDY DESIGN
Multicentered randomized controlled trial.


OBJECTIVES
To determine if previously validated low back pain (LBP) subgroups respond differently to contrasting exercise prescriptions.


SUMMARY OF BACKGROUND DATA
The role of "patient-specific" exercises in managing LBP is controversial.


METHODS
A total of 312 acute, subacute, and chronic patients, including LBP-only and sciatica, underwent a standardized mechanical assessment classifying them by their pain response, specifically eliciting either a "directional preference" (DP) (i.e., an immediate, lasting improvement in pain from performing either repeated lumbar flexion, extension, or sideglide/rotation tests), or no DP. Only DP subjects were randomized to: 1) directional exercises "matching" their preferred direction (DP), 2) exercises directionally "opposite" their DP, or 3) "nondirectional" exercises. Outcome measures included pain intensity, location, disability, medication use, degree of recovery, depression, and work interference.


RESULTS
A DP was elicited in 74% (230) of subjects. One third of both the opposite and non-directionally treated subjects withdrew within 2 weeks because of no improvement or worsening (no matched subject withdrew). Significantly greater improvements occurred in matched subjects compared with both other treatment groups in every outcome (P values <0.001), including a threefold decrease in medication use.


CONCLUSIONS
Consistent with prior evidence, a standardized mechanical assessment identified a large subgroup of LBP patients with a DP. Regardless of subjects' direction of preference, the response to contrasting exercise prescriptions was significantly different: exercises matching subjects' DP significantly and rapidly decreased pain and medication use and improved in all other outcomes. If repeatable, such subgroup validation has important implications for LBP management.
Sentiment analysis of online news text: a case study of appraisal theory

Purpose. Sentiment analysis and emotion processing are attracting increasing interest in many fields. Computer and information scientists are developing automated methods for sentiment analysis of online text. Most of the research have focused on identifying sentiment polarity or orientation—whether a document, usually product or movie review, carries a positive or negative sentiment. It is time for researchers to address more sophisticated kinds of sentiment analysis. This paper evaluates a particular linguistic framework called appraisal theory for adoption in manual as well as automatic sentiment analysis of news text. Methodology. The appraisal theory is applied to the analysis of a sample of political news articles reporting on Iraq and economic policies of George W. Bush and Mahmoud Ahmadinejad to assess its utility and to identify challenges in adopting this framework. Findings. The framework was useful in uncovering various aspects of sentiment that should be useful to researchers such as the appraisers and object of appraisal, bias of the appraisers and the author, type of attitude and manner of expressing the sentiment. Problems encountered include difficulty in identifying appraisal phrases and attitude categories because of the subtlety of expression in political news articles, lack of treatment of tense and timeframe, lack of a typology of emotions, and need to identify different types of behaviors (political, verbal and material actions) that reflect sentiment. Value. The study has identified future directions for research in automated sentiment analysis as well as sentiment analysis of online news text. It has also demonstrated how sentiment analysis of news text can be carried out.
HIV Shedding from Male Circumcision Wounds in HIV-Infected Men: A Prospective Cohort Study

BACKGROUND
A randomized trial of voluntary medical male circumcision (MC) of HIV-infected men reported increased HIV transmission to female partners among men who resumed sexual intercourse prior to wound healing. We conducted a prospective observational study to assess penile HIV shedding after MC.


METHODS AND FINDINGS
HIV shedding was evaluated among 223 HIV-infected men (183 self-reported not receiving antiretroviral therapy [ART], 11 self-reported receiving ART and had a detectable plasma viral load [VL], and 29 self-reported receiving ART and had an undetectable plasma VL [<400 copies/ml]) in Rakai, Uganda, between June 2009 and April 2012. Preoperative and weekly penile lavages collected for 6 wk and then at 12 wk were tested for HIV shedding and VL using a real-time quantitative PCR assay. Unadjusted prevalence risk ratios (PRRs) and adjusted PRRs (adjPRRs) of HIV shedding were estimated using modified Poisson regression with robust variance. HIV shedding was detected in 9.3% (17/183) of men not on ART prior to surgery and 39.3% (72/183) of these men during the entire study. Relative to baseline, the proportion shedding was significantly increased after MC at 1 wk (PRR = 1.87, 95% CI = 1.12-3.14, p = 0.012), 2 wk (PRR = 3.16, 95% CI = 1.94-5.13, p < 0.001), and 3 wk (PRR = 1.98, 95% CI = 1.19-3.28, p = 0.008) after MC. However, compared to baseline, HIV shedding was decreased by 6 wk after MC (PRR = 0.27, 95% CI = 0.09-0.83, p = 0.023) and remained suppressed at 12 wk after MC (PRR = 0.19, 95% CI = 0.06-0.64, p = 0.008). Detectable HIV shedding from MC wounds occurred in more study visits among men with an HIV plasma VL > 50,000 copies/ml than among those with an HIV plasma VL < 400 copies/ml (adjPRR = 10.3, 95% CI = 4.25-24.90, p < 0.001). Detectable HIV shedding was less common in visits from men with healed MC wounds compared to visits from men without healed wounds (adjPRR = 0.12, 95% CI = 0.07-0.23, p < 0.001) and in visits from men on ART with undetectable plasma VL compared to men not on ART (PRR = 0.15, 95% CI = 0.05-0.43, p = 0.001). Among men with detectable penile HIV shedding, the median log10 HIV copies/milliliter of lavage fluid was significantly lower in men with ART-induced undetectable plasma VL (1.93, interquartile range [IQR] = 1.83-2.14) than in men not on ART (2.63, IQR = 2.28-3.22, p < 0.001). Limitations of this observational study include significant differences in baseline covariates, lack of confirmed receipt of ART for individuals who reported ART use, and lack of information on potential ART initiation during follow-up for those who were not on ART at enrollment.


CONCLUSION
Penile HIV shedding is significantly reduced after healing of MC wounds. Lower plasma VL is associated with decreased frequency and quantity of HIV shedding from MC wounds. Starting ART prior to MC should be considered to reduce male-to-female HIV transmission risk. Research is needed to assess the time on ART required to decrease shedding, and the acceptability and feasibility of initiating ART at the time of MC.
Cortical mapping with navigated transcranial magnetic stimulation in low-grade glioma surgery

UNLABELLED
Transcranial magnetic stimulation (TMS) is a promising method for both investigation and therapeutic treatment of psychiatric and neurologic disorders and, more recently, for brain mapping. This study describes the application of navigated TMS for motor cortex mapping in patients with a brain tumor located close to the precentral gyrus.


MATERIALS AND METHODS
In this prospective study, six patients with low-grade gliomas in or near the precentral gyrus underwent TMS, and their motor responses were correlated to locations in the cortex around the lesion, generating a functional map overlaid on three-dimensional magnetic resonance imaging (MRI) scans of the brain. To determine the accuracy of this new method, we compared TMS mapping with the gold standard mapping with direct cortical electrical stimulation in surgery. The same navigation system and TMS-generated map were used during the surgical resection procedure.


RESULTS
The motor cortex could be clearly mapped using both methods. The locations corresponding to the hand and forearm, found during intraoperative mapping, showed a close spatial relationship to the homotopic areas identified by TMS mapping. The mean distance between TMS and direct cortical electrical stimulation (DES) was 4.16 ± 1.02 mm (range: 2.56-5.27 mm).


CONCLUSION
Preoperative mapping of the motor cortex with navigated TMS prior to brain tumor resection is a useful presurgical planning tool with good accuracy.
Visiting theories that predict college students' self-disclosure on Facebook

This study explores factors that may explain information disclosure behavior on Facebook and provides understanding of each factor’s contribution in explaining such behavior. Factors tested in this study are drawn from theories (e.g., social contract theory and uses and gratification theory) and constructs (e.g., trust/self-disclosure relationships, time spent on Facebook, number of Facebook friends, and gender difference). Findings suggest the potential of all the factors examined in this study as frameworks to explain self-disclosure behavior on Facebook. This social media-specific study offers evidence that these theories may have implications that are different from the current e-commerce literature on self-disclosure. Both theoretical and practical implications are discussed. 2013 Elsevier Ltd. All rights reserved.
Prediction of illness severity in patients with major depression using structural MR brain scans.

PURPOSE
To develop a model for the prediction of Major Depressive Disorder (MDD) illness severity ratings from individual structural MRI brain scans.


MATERIALS AND METHODS
Structural T1-weighted MRI scans were obtained from 30 patients with MDD recruited from two different scanning centers. Self-rated (Beck Depression Inventory; BDI), and clinician-rated (Hamilton Rating Scale for Depression, HRSD), syndrome-specific illness severity ratings were obtained just before scanning. Relevance vector regression (RVR) was used to predict the scores (BDI, HRSD) from T1-weighted MRI scans.


RESULTS
It was possible to predict the BDI score (correlation between actual score and RVR predicted scores r = 0.694; P < 0.0001), but not the HRSD scores (r = 0.34; P = 0.068) from individual subjects. BDI scores from the most ill patients were predicted more accurately than those from patients who were least ill (standard deviation of difference between predicted and actual scores 2.5 versus 7.4, respectively).


CONCLUSION
These data suggest that T1-weighted MRI scans contain sufficient information about neurobiological change in patients with MDD to permit accurate predictions about illness severity, on an individual subject basis, particularly for the most ill patients.
Flipper: a new method of digital document navigation

Page flipping is an important part of paper-based document navigation. However this affordance of paper document has not been fully transferred to digital documents. In this paper we present Flipper, a new digital document navigation technique inspired by paper document flipping. Flipper combines speed-dependent automatic zooming (SDAZ) [6] and rapid serial visual presentation (RSVP) [3], to let users navigate through documents at a wide range of speeds. It is particularly well adapted to rapid visual search. User studies show Flipper is faster than both conventional scrolling and SDAZ and is well received by users.
Efficacy and tolerability of transdermal granisetron for the control of chemotherapy-induced nausea and vomiting associated with moderately and highly emetogenic multi-day chemotherapy: a randomized, double-blind, phase III study

A novel transdermal formulation of granisetron (the granisetron transdermal delivery system (GTDS)) has been developed to deliver granisetron continuously over 7 days. This double-blind, phase III, non-inferiority study compared the efficacy and tolerability of the GTDS to daily oral granisetron for the control of chemotherapy-induced nausea and vomiting (CINV). Six hundred forty-one patients were randomized to oral (2 mg/day, 3–5 days) or transdermal granisetron (one GTDS patch, 7 days), before receiving multi-day chemotherapy. The primary endpoint was complete control of CINV (no vomiting/retching, no more than mild nausea, no rescue medication) from chemotherapy initiation until 24 h after final administration. The prespecified non-inferiority margin was 15%. Five hundred eighty-two patients were included in the per protocol analysis. The GTDS displayed non-inferiority to oral granisetron: complete control was achieved by 60% of patients in the GTDS group, and 65% in the oral granisetron group (treatment difference, −5%; 95% confidence interval, −13–3). Both treatments were well tolerated, the most common adverse event being constipation. The GTDS provides effective, well-tolerated control of CINV associated with moderately or highly emetogenic multi-day chemotherapy. It offers a convenient alternative route for delivering granisetron for up to 7 days that is as effective as oral granisetron.