LLukas22/scidocs huggingface dataset:
Estimating treatment effects for individual patients based on the results of randomised clinical trials

OBJECTIVES
To predict treatment effects for individual patients based on data from randomised trials, taking rosuvastatin treatment in the primary prevention of cardiovascular disease as an example, and to evaluate the net benefit of making treatment decisions for individual patients based on a predicted absolute treatment effect.


SETTING
As an example, data were used from the Justification for the Use of Statins in Prevention (JUPITER) trial, a randomised controlled trial evaluating the effect of rosuvastatin 20 mg daily versus placebo on the occurrence of cardiovascular events (myocardial infarction, stroke, arterial revascularisation, admission to hospital for unstable angina, or death from cardiovascular causes). Population 17,802 healthy men and women who had low density lipoprotein cholesterol levels of less than 3.4 mmol/L and high sensitivity C reactive protein levels of 2.0 mg/L or more.


METHODS
Data from the Justification for the Use of Statins in Prevention trial were used to predict rosuvastatin treatment effect for individual patients based on existing risk scores (Framingham and Reynolds) and on a newly developed prediction model. We compared the net benefit of prediction based rosuvastatin treatment (selective treatment of patients whose predicted treatment effect exceeds a decision threshold) with the net benefit of treating either everyone or no one.


RESULTS
The median predicted 10 year absolute risk reduction for cardiovascular events was 4.4% (interquartile range 2.6-7.0%) based on the Framingham risk score, 4.2% (2.5-7.1%) based on the Reynolds score, and 3.9% (2.5-6.1%) based on the newly developed model (optimal fit model). Prediction based treatment was associated with more net benefit than treating everyone or no one, provided that the decision threshold was between 2% and 7%, and thus that the number willing to treat (NWT) to prevent one cardiovascular event over 10 years was between 15 and 50.


CONCLUSIONS
Data from randomised trials can be used to predict treatment effect in terms of absolute risk reduction for individual patients, based on a newly developed model or, if available, existing risk scores. The value of such prediction of treatment effect for medical decision making is conditional on the NWT to prevent one outcome event. Trial registration number Clinicaltrials.gov NCT00239681.
Balancing Wireless Data Broadcasting and Information Hovering for Efficient Information Dissemination

Wireless data broadcasting is an efficient, bandwidth preserving way of data dissemination. However, as the amount of data increases, the waiting time of the clients becomes unacceptably high. The present paper proposes the combination of optimal wireless broadcasting and information hovering, as an effective means of performance improvement in vehicular networks with locality of demand. While state-of-the-art works exploit user collaboration only as a means of wireless coverage extension, the proposed scheme proposes parallel dissemination through broadcasting and user networking over the whole studied area. Optimal, periodic broadcast scheduling is adopted at the highest tier for data dissemination. At the lowest tier, users can exploit information hovering around selected anchoring points, in order to retrieve data faster than their next scheduled broadcast. The issue of sharing the dissemination load optimally between the broadcasting and the hovering subsystems is mapped to the classic pull-push balancing problem. Through analysis, the long-standing “optimal cut-off point” balancing method is shown to be suboptimal, and a new method is proposed which achieves lower client serving time in any of the cases. Simulation results in realistic VANETs show that the proposed dissemination scheme surpasses state-of-the-art works in terms of efficiency and client satisfaction.
Impact of adjuvant chemotherapy and pelvic radiation on pattern of recurrence and outcome in stage I non-invasive uterine papillary serous carcinoma. A multi-institution study.

OBJECTIVES
To determine the impact of adjuvant chemotherapy or pelvic radiation on risk of recurrence and outcome in stage IA non-invasive uterine papillary serous carcinoma (UPSC).


METHODS
This is a multi-institutional retrospective study for 115 patients with stage IA non-invasive UPSC (confined to endometrium) treated between 2000 and 2012. Kaplan-Meier and multivariable Cox proportional hazards regression modeling were used.


RESULTS
Staging lymphadenectomy and omentectomy were performed in 84% and 57% respectively. Recurrence was seen in 26% (30/115). Sites of recurrences were vaginal in 7.8% (9/115), pelvic in 3.5% (4/115) and extra-pelvic in 14.7% (17/115). Adjuvant chemotherapy did not impact risk of recurrence (25.5% vs. 26.9%, p=0.85) even in subset of patients who underwent lymphadenectomy (20% vs. 23.5%, p=0.80). These findings were consistent for pattern of recurrence. Among those who underwent lymphadenectomy, adjuvant chemotherapy did not impact progression-free survival (p=0.34) and overall survival (p=0.12). However among patients who did not have lymphadenectomy, adjuvant chemotherapy or pelvic radiation was associated with longer progression-free survival (p=0.04) and overall survival (p=0.025). In multivariable analysis, only staging lymphadenectomy was associated with improved progression-free survival (HR 0.34, 95% CI 0.12-0.95, p=0.04) and overall survival (HR 0.35, 95% CI 0.12-1.0, p=0.05). Neither adjuvant chemotherapy nor pelvic radiation were predictors of progression-free or overall survivals.


CONCLUSION
In stage IA non-invasive UPSC, staging lymphadenectomy was significantly associated with recurrence and outcome and therefore, should be performed in all patients. Adjuvant chemotherapy or pelvic radiation had no impact on outcome in surgically staged patients but was associated with improved outcome in unstaged patients.
Paratesticular rhabdomyosarcoma in children and adolescents-Outcome and patterns of relapse when utilizing a nonsurgical strategy for lymph node staging: Report from the International Society of Paediatric Oncology (SIOP) Malignant Mesenchymal Tumour 89 and 95 studies.

PURPOSE
To report the results from International Society of Pediatric Oncology (SIOP) Malignant Mesenchymal Tumors studies (MMT 89 and 95) of males with nonmetastatic paratesticular rhabdomyosarcoma.


METHODS
From 1989 to 2003, 159 patients were included. Radical inguinal orchidectomy was recommended, but retroperitoneal lymph node (LN) assessment was based on imaging alone. The treatment was stratified by stage (SIOP tumor-node-metastasis staging system) and histology.


RESULTS
Median age at presentation was 5.6 years (range 0.3-17.6) and 120 patients were of <10 years (75%). Patients ≥10 years had tumors of >5 cm more frequently compared to patients of <10 years (54% vs. 22%, P = 0.0004). The 5- year overall and progression-free survivals were 94% and 83%, respectively. Seventy-eight percent of relapses occurred in the retroperitoneal LN. Thirty-one percent of stage N0 patients of age ≥10 years developed node relapse, compared with 8% of N0 patients aged <10 years (P = 0.0005).


CONCLUSIONS
Older patients with paratesticular rhabdomyosarcoma have a significant risk of LN relapse. These results support a surgical approach to LN staging in this subgroup of patients.
Tooth wear: prevalence and associated factors in general practice patients.

OBJECTIVES
To estimate the prevalence of tooth wear and to investigate factors associated with tooth wear in patients from general practices in the Northwest United States.


METHODS
Data on the diagnosis and treatment of oral diseases during the previous year were collected in a survey with a systematic random sample of patients (n= 1530) visiting general dentists from the Northwest Practice-based REsearch Collaborative in Evidence-based DENTistry (PRECEDENT) (n=80). Prevalence ratios (PRs) of moderate to severe occlusal and incisal tooth wear by patient characteristics were estimated using cluster-adjusted multiple binomial regression for adults (18+ years) and children/adolescents (3-17 years).


RESULTS
For adults, the mean number of teeth with wear facets was 5.4 [95% confidence interval (CI) =4.6-6.2] and 51% of the adults had four or more teeth with wear. Participants 45-64 and 65+ years old were 1.3 (95% CI=1.1-1.6) and 1.4 (95% CI=1.1-1.8) times as likely to have 4+ teeth with moderate to severe wear facets as participants 18-44 years old. Adult males had a 20% (PR=1.2; 95% CI=1.1-1.4) higher prevalence of wear than adult females. Adults who were using, or had ever used occlusal splints had higher prevalence of tooth wear compared to those who never used such appliances (PR=1.3; 95% CI=1.0-1.5). Adults with any periodontal bone loss also had a 20% higher prevalence of wear than adults without periodontal disease (PR=1.2; 95% CI=1.0-1.4). For children/adolescents, the mean number of teeth with moderate to severe wear facets was 1.6 (95% CI=0.9-2.6) and 31% of the children had one or more teeth with wear facets. The adjusted prevalence ratio of tooth wear (1+ teeth with wear facets) for boys was 1.6 times as high (95% CI=1.1-2.4) as compared with girls. The prevalence of wear for children 12+ years old was 50% (PR=0.5; 95% CI=0.3-0.8) lower than that of children <12 years old. Angle's class II was associated with higher tooth wear prevalence (PR= 1.8; 95% CI=1.3-2.6) than class I. Children with posterior or anterior open bite had lower prevalence of wear than their counterparts (PR=0.6; 95% CI=0.3-1.0). No associations were observed between tooth wear and orthodontic treatment, missing teeth, and race/ethnicity.


CONCLUSION
Tooth wear is a prevalent condition in this population. Among adults, higher prevalences of tooth wear were observed among those who were older, males, had used occlusal splints and had periodontal disease. Among children, higher prevalences were associated with younger age, male gender, class II malocclusion and the absence of open bite. Submitted on behalf of the Northwest PRECEDENT network, with support from NIDCR grants DE016750 and DE016752.
Reattachment of the proximal hamstring origin: outcome in patients with partial and complete tears

To assess the subjective and functional outcome in complete and partial injuries, both acute and chronic. One hundred and thirty-two consecutive proximal hamstring reattachments were performed by a single surgeon between 1999 and 2009. The mean age at the time of operation was 42.5 years (SD 12.2), the mean duration of follow-up was 53.8 months (SD 19.5), and all patients with a minimum 2-year follow-up were included in the study. Patients were reviewed independently. Functional outcome was evaluated using quantitative assessments of pre-operative and postoperative hamstring strength and endurance, while subjective outcome was undertaken at the latest follow-up using a three-tier questionnaire. The most common cause of injury was waterskiing (29 patients). There were 96 complete injuries and 36 partial injuries. Overall, 112 of 132 patients rated their result as good/excellent, 91 had returned to their pre-injury level of sporting activity, and 114 said that they would undergo surgery again. Mean postoperative hamstring strength was 83 %, and mean hamstring endurance was 108 % compared to the contralateral limb. Patients with complete injuries and those operated and those operated on acutely (<6 weeks) were more likely to have a good/excellent result. There was no significant correlation between time to repair, type of injury (partial vs. complete) and functional outcome. Good to excellent results can be expected in the majority of patients, following surgical reattachment. Surgery is well tolerated with the vast majority of patients, reporting that they would undergo surgery again. IV.
Therabot™: A Robotic Support Companion

Therabot is a robotic therapy support system designed to supplement a therapist and to provide support to patients diagnosed with conditions associated with trauma and adverse events. The system takes on the form factor of a floppy-eared dog which fits in a person»s lap and is designed for patients to provide support and encouragement for home therapy exercises and in counseling.
Simulation and Measurement of Lightning-Impulse Voltage Distributions Over Transformer Windings

This paper presents: 1) a novel method for accurate high-frequency modeling of dry-type transformer windings based on magnetic and electric field simulations for parameter extraction of the detailed equivalent circuit of the entire winding system; 2) a method for fast and accurate transient solution of the circuit differential equations that describe the voltage distribution over the winding system; 3) an efficient, cheap, and nondestructive low-voltage measurement system based on a self-developed lightning-impulse generator; and 4) verification of the simulation results by comparison with measurement.
Thermal effect on the microstructure of the lattice structure Cu-10Sn alloy fabricated through selective laser melting

Abstract Cu-10Sn alloy with body-center-cubic (BCC) lattice structure was fabricated through selective laser melting (SLM). The geometry of SLMed BCC lattice Cu-10Sn alloy (rod diammeter ∼300 μm, length ∼700 μm) was in good agreement with the design model. Similar with the nearly full density Cu-10Sn alloy, columnar also constituted the majority parts of the lattice structure Cu-10Sn, but exhibited various morphologies due to the different grain growth orientation under thermal effect. The gowth orientation of columnar grain in the rods oriented to the as-fabricated layer due to the higher thermal conductivity of the as-fabricated layers.
Improvement of gas turbine performance based on inlet air cooling systems: A technical review

Performance of a gas turbine is mainly depends on the inlet air temperature. The power output of a gas turbine depends on the flow of mass through it. This is precisely the reason why on hot days, when air is less dense, power output falls off. A rise of 1°C temperature of inlet air decreases the power output by 1%. The aim of this paper is to review up to date techniques that were developed to cool inlet air to gas turbine. The techniques including the mechanical chillers, media type evaporative coolers and absorption chillers have been reviewed. It is found that the power consumption of the cool inlet air is of considerable concern since it decreases the net power output of gas turbine. In addition, the mechanical chiller auxiliary power consumption is very high compared to media type evaporative coolers. Furthermore, the reviewed works revealed that the efficiency of evaporative cooler largely depends on moisture present in the air. The gas turbine power augmentation through inlet air chilling is effectively used to boost power during high ambient temperature usually synchronous with on-peak power generation, allowing levelling of gas turbine power output.
Chronic obstructive pulmonary disease in Portugal: Pneumobil (1995) and 2002 prevalence studies revisited.

BACKGROUND
Chronic Obstructive Pulmonary Disease (COPD) has been a leading cause of morbidity and mortality worldwide, over the years. In 1995, the implementation of a respiratory function survey seemed to be an adequate way to draw attention to neglected respiratory symptoms and increase the awareness of spirometry surveys. By 2002 there were new consensual guidelines in place and the awareness that prevalence of COPD depended on the criteria used for airway obstruction definition. The purpose of this study is to revisit the two studies and to turn public some of the data and respective methodologies.


METHODS
From Pneumobil study database of 12,684 subjects, only the individuals with 40+ years old (n = 9.061) were selected. The 2002 study included a randomized representative sample of 1,384 individuals with 35-69 years old.


RESULTS
The prevalence of COPD was 8.96% in Pneumobil and 5.34% in the 2002 study. In both studies, presence of COPD was greater in males and there was a positive association between presence of COPD and older age groups. Smokers and ex-smokers showed a higher proportion of cases of COPD.


CONCLUSIONS
Prevalence in Portugal is lower than in other European countries. This may be related to lower smokers' prevalence. Globally, the most important risk factors associated with COPD were age over 60 years, male gender and smoking exposure. All aspects and limitations regarding different recruitment methodologies and different criteria for defining COPD cases highlight the need of a standardized method to evaluate COPD prevalence and associated risks factors, whose results can be compared across countries, as it is the case of BOLD project.
Verification of database-driven systems via amalgamation

We describe a general framework for static verification of systems that base their decisions upon queries to databases. The database is specified using constraints, typically a schema, and is not modified during a run of the system. The system is equipped with a finite number of registers for storing intermediate information from the database and the specification consists of a transition table described using quantifier-free formulas that can query either the database or the registers.
 Our main result concerns systems querying XML databases -- modeled as data trees -- using quantifier-free formulas with predicates such as the descendant axis or comparison of data values. In this scenario we show an ExpSpace algorithm for deciding reachability.
 Our technique is based on the notion of amalgamation and is quite general. For instance it also applies to relational databases (with an optimal PSpace algorithm). We also show that minor extensions of the model lead to undecidability.
Automated 3-dimensional elastic registration of whole-body PET and CT from separate or combined scanners.

UNLABELLED
Registration and fusion of whole-body functional PET and anatomic CT is significant for accurate differentiation of viable tumors from benign masses, radiotherapy planning and monitoring treatment response, and cancer staging. Whole-body PET and CT acquired on separate scanners are misregistered because of differences in patient positions and orientations, couch shapes, and breathing protocols. Although a combined PET/CT scanner removes many of these misalignments, breathing-related nonrigid mismatches still persist.


METHODS
We have developed a new, fully automated normalized mutual information-based 3-dimensional elastic image registration technique that can accurately align whole-body PET and CT images acquired on stand-alone scanners as well as a combined PET/CT scanner. The algorithm morphs the PET image to align spatially with the CT image by generating an elastic transformation field by interpolating quaternions and translations from multiple 6-parameter rigid-body registrations, each obtained for hierarchically subdivided image subvolumes. Fifteen whole-body (spanning thorax and abdomen) PET/CT image pairs acquired separately and 5 image pairs acquired on a combined scanner were registered. The cases were selected on the basis of the availability of both CT and PET images, without any other screening criteria, such as a specific clinical condition or prognosis. A rigorous quantitative validation was performed by evaluating algorithm performance in the context of variability among 3 clinical experts in the identification of up to 32 homologous anatomic landmarks.


RESULTS
The average execution time was 75 and 45 min for images acquired using separate scanners and combined scanner, respectively. Visual inspection indicated improved matching of homologous structures in all cases. The mean registration accuracy (5.5 and 5.9 mm for images from separate scanners and combined scanner, respectively) was found comparable to the mean interexpert difference in landmark identification (5.6 +/- 2.4 and 6.6 +/- 3.4 mm, respectively). The variability in landmark identification did not show statistically significant changes on replacing any expert by the algorithm.


CONCLUSION
We have presented a new and automated elastic registration algorithm to correct for nonrigid misalignments in whole-body PET/CT images as well as improve the "mechanical" registration of a combined PET/CT scanner. The algorithm performance was on par with the average opinion of 3 experts.
Clinical measurement of addictions.

INTRODUCTION AND AIMS
To conduct a systematic review of instruments for the clinical measurement of addictive behaviours and to determine whether substance addictive behaviours (SAB) and non-substance addictive behaviours (NSAB) are similarly conceptualised in clinical research.


DESIGN AND METHODS
The analytic strategy employed comprised three steps: (i) major search engines were used to take stock of available clinical instruments for assessing addictive behaviours; (ii) an analysis grid was developed and validated, covering 21 parameters under four heuristic categories: dependence, temperament, social handicap and cognitive behaviour; and (iii) all instruments were analysed and compared via the grid.


RESULTS
The search yielded 157 questionnaires covering 14 addictive behaviours.The analysis grid allowed rating all questionnaire items on one parameter only; very good interrater agreement was maintained throughout.The categories most evaluated by the questionnaires were dependence and cognitive behaviour; temperament and social handicap were much less frequently considered. Patterns were generally similar in terms of categories, whether questionnaires concerned SAB or NSAB; however, differences within categories indicated a greater frequency of psychologically oriented parameters for NSAB.


CONCLUSIONS
The measurement of addictive behaviours appears clinically cohesive, as determined by a validated analysis grid applied to an exhaustive set of questionnaires identified through a systematic literature review.
Visual Cryptography

In this paper we consider a new type of cryptographic scheme, which can decode concealed images without any cryptographic computations. The scheme is perfectly secure and very easy to implement. We extend it into a visual variant of the k out of n secret sharing problem, in which a dealer provides a transparency to each one of the n users; any k of them can see the image by stacking their transparencies, but any k 1 of them gain no information about it. A preliminary version of this paper appeared in Eurocrypt 94. y Dept. of Applied Mathematics and Computer Science, Weizmann Institute of Science, Rehovot 76100, Israel. E-mail: naor@wisdom.weizmann.ac.il. Research supported by an Alon Fellowship and a grant from the Israel Science Foundation administered by the Israeli Academy of Sciences. z Dept. of Applied Mathematics and Computer Science, Weizmann Institute of Science, Rehovot 76100, Israel. E-mail: shamir@wisdom.weizmann.ac.il.
Advances in minimal processing of fruits and vegetables: a review

This paper covers an exhaustive review on advances in minimal processing of fruits and vegetables. The review includes an exclusive discussion on production chain of minimally processed products from raw material selection to its consumption with different aspects including food safety issues. The intent is to provide a level of understanding that can be used to underpin future research directions in order to resolve existing issues that limit fresh-cut quality and shelf life.