LLukas22/scidocs huggingface dataset:
Hypofractionation with simultaneous integrated boost for early breast cancer

To evaluate the feasibility of hypofractionation with SIB in all settings in Germany to prepare a multicenter treatment comparison. Eligible patients had histopathologically confirmed breast cancer operated by BCS. Patients received WBI 40.0 Gy in 16 fractions of 2.5 Gy. A SIB with 0.5 Gy per fraction was administered to the tumor bed, thereby giving 48.0 Gy in 16 fractions to the boost-PTV sparing heart, LAD, lung, contralateral breast. The primary study objective was feasibility, administration of specified dose in 16 fractions within 22–29 days with adherence to certain dose constraints (heart; LAD; contralateral breast); secondary endpoints were toxicity, QoL. 151 patients were recruited from 7 institutions between 07/11-10/12. 10 patients met exclusion criteria prior to irradiation. All but two patients (99 %) received the prescribed dose in the PTVs. Adherence to dose constraints and time limits was achieved in 89 % (95 % CI 82 % to 93 %). 11 AE were reported in 10 patients; five related to concurrent endocrine therapy. Two of the AEs were related to radiotherapy: grade 3 hot flushes in two cases. QoL remained unchanged. Hypofractionation with a SIB is feasible and was well tolerated in this study. Die ARO-2010-01-Studie prüfte die Durchführbarkeit einer hypofraktionierten Bestrahlung mit simultan-integriertem Boost (SIB) in unterschiedlichen Versorgungseinrichtungen zur Vorbereitung einer multizentrischen Vergleichsstudie. In die Studie rekrutiert wurden Patientinnen mit histopathologisch gesichertem Mammakarzinom nach brusterhaltender Operation. Bestrahlt wurde die Brust mit 40,0 Gy in 16 Fraktionen à 2,5 Gy Einzeldosis; zusätzlich wurde bei jeder Fraktion ein simultan- integrierter Boost mit 0,5 Gy appliziert, so dass im Boost-PTV (Planungszielvolumen) eine Dosis von 48 Gy in 16 Fraktionen erreicht wurde. Das primäre Zielkriterium war die Durchführbarkeit, definiert als Verabreichung von 48 Gy GD in 16 Fraktionen in mindestens 22 d bis maximal 29 d Therapiezeit unter Einhaltung von Grenzdosen (Lunge, Herz, LAD, kontralaterale Brust); sekundäre Endpunkte waren Toxizität und Lebensqualität. Zwischen 07/2011 und 10/2012 wurden 151 Patientinnen in 7 Prüfzentren rekrutiert. Bei 10 Patientinnen wurden vor der Strahlentherapie Ausschlusskriterien festgestellt. Fast alle Patientinnen (99 %) erhielten die verschriebene Dosis im PTV. Grenzdosen und Zeitlimits wurden in 89 % (95 % CI 82 % bis 93 %) eingehalten. 11 unerwünschte Ereignisse wurden bei 10 Patientinnen gemeldet; fünf in Verbindung mit gleichzeitiger endokriner Therapie. In 2 Fällen wurde eine kausale Beziehung zur Strahlentherapie angegeben: Grad-3-Hitzewallungen. Die Lebensqualität blieb unverändert. Die hypofraktionierte Bestrahlung mit simultan-integriertem Boost konnte in dieser multizentrischen Studie in Praxen und Strahlenkliniken problemlos durchgeführt werden. Die Verträglichkeit war in dieser Studie gut.
Expressivity of coalgebraic modal logic: The limits and beyond

Modal logic has a good claim to being the logic of choice for describing the reactive behaviour of systems modelled as coalgebras. Logics with modal operators obtained from so-called predicate liftings have been shown to be invariant under behavioural equivalence. Expressivity results stating that, conversely, logically indistinguishable states are behaviourally equivalent depend on the existence of separating sets of predicate liftings for the signature functor at hand. Here, we provide a classification result for predicate liftings which leads to an easy criterion for the existence of such separating sets, and we give simple examples of functors that fail to admit expressive normal or monotone modal logics, respectively, or in fact an expressive (unary) modal logic at all. We then move on to polyadic modal logic, where modal operators may take more than one argument formula. We show that every accessible functor admits an expressive polyadic modal logic. Moreover, expressive polyadic modal logics are, unlike unary modal logics, compositional. c © 2007 Elsevier B.V. All rights reserved.
An approach to blind source separation based on temporal structure of speech signals

In this paper we introduce a new technique for blind source separation of speech signals. We focus on the temporal structure of the signals in contrast to most other major approaches to this problem. The idea is to apply the decorrelation method proposed by Molgedey and Schuster in the time-frequency domain. We show some results of experiments with both artificially controlled data and speech data recorded in the real environment.
A fast stereo matching algorithm suitable for embedded real-time systems

In this paper, the challenge of fast stereo matching for embedded systems is tackled. Limited resources, e.g. memory and processing power, and most importantly real-time capability on embedded systems for robotic applications, do not permit the use of most sophisticated stereo matching approaches. The strengths and weaknesses of different matching approaches have been analyzed and a wellsuited solution has been found in a Census-based stereo matching algorithm. The novelty of the algorithm used is the explicit adaption and optimization of the wellknown Census transform in respect to embedded real-time systems in software. The most important change in comparison with the classic Census transform is the usage of a sparse Census mask which halves the processing time with nearly unchanged matching quality. This is due the fact that large sparse Census masks perform better than small dense masks with the same processing effort. The evidence of this assumption is given by the results of experiments with different mask sizes. Another contribution of this work is the presentation of a complete stereo matching system with its correlation-based core algorithm, the detailed analysis and evaluation of the results, and the optimized high speed realization on different embedded and PC platforms. The algorithm handles difficult areas for stereo matching, such as areas with low texture, very well in comparison to state-ofthe-art real-time methods. It can successfully eliminate false positives to provide Email addresses: martin.humenberger@ait.ac.at (Martin Humenberger), christian.zinner@ait.ac.at (Christian Zinner), michael.weber@ait.ac.at (Michael Weber), wilfried.kubinger@ait.ac.at (Wilfried Kubinger), vincze@acin.tuwien.ac.at (Markus Vincze) Preprint submitted to Computer Vision and Image Understanding January 4, 2010 reliable 3D data. The system is robust, easy to parameterize and offers high flexibility. It also achieves high performance on several, including resource-limited, systems without losing the good quality of stereo matching. A detailed performance analysis of the algorithm is given for optimized reference implementations on various commercial of the shelf (COTS) platforms, e.g. a PC, a DSP and a GPU, reaching a frame rate of up to 75 fps for 640× 480 images and 50 disparities. The matching quality and processing time is compared to other algorithms on the Middlebury stereo evaluation website reaching a middle quality and top performance rank. Additional evaluation is done by comparing the results with a very fast and well-known sum of absolute differences algorithm using several Middlebury datasets and real-world scenarios.
Alterations in HbA1c following minimal or enhanced non-surgical, non-antibiotic treatment of gingivitis or mild periodontitis in type 2 diabetic patients: a pilot trial.

AIM
The purpose of this pilot study was to determine and compare the effects of two protocols aimed at reducing periodontal inflammation, upon the metabolic control of the diabetic condition in subjects with elevated baseline glycosylated hemoglobin (HbA1c).


METHODS AND MATERIALS
Forty-two non-smoking type 2 diabetes subjects with mildly elevated HbA1c (>7 but < 9%) and severely elevated (>9%) were randomized to one of two non-surgical periodontal therapy protocols. Patients in the "minimal therapy" (MT) group received scaling, root planning, and oral hygiene instructions on two occasions six months apart. Participants randomized to the "frequent therapy" (FT) protocol received scaling, root planing, and oral hygiene instructions at two-month intervals and were provided a 0.12% chlorhexidine rinse for home use twice daily. Neither systemic nor local antibiotics were provided to either group. Subjects were asked to report any changes in diabetic medications, nutrition, and physical activity. Data analyses (ANOVA, t-test, Mann-Whitney) grouped subjects according to baseline HbA1c (>7 and < 9%, or > 9%), treatment protocol (minimal or frequent), and +/- medication change.


RESULTS
In both MT and FT groups the clinical attachment level (CAL) remained unchanged but the other measures [gingival index (GI) and pocket dept (PD)] of periodontal health improved. Mean reductions in plaque showed improvement but calculus was worse in the FT group, likely due to the use of chlorhexidine. At six months, the largest reduction of HbA1c was 3.7; experienced by a subject receiving FT but no changes in diabetic medication. Among the MT and no medication change subjects, the maximum reduction was 1.6. Overall mean reduction in HbA1c of 27 subjects with baseline HbA1c >9.0 and no medication change was 0.6 with no statistical difference between the MT and FT groups. Among the medication-change subjects with baseline HbA1c >9.0, mean reduction of 1.38 was seen with FT compared to 1.10 with MT.


CONCLUSION
Overall, modest improvements in HbA1c were detected with a trend towards FT being better than MT. Although this pilot trial was under-powered to detect small between-group differences, the magnitude of our findings (0.6 mean improvement in HbA1c) matches closely findings from the only meta-analysis conducted on this topic to date. Larger scale studies must be undertaken on diabetic patients with periodontal problems.


CLINICAL SIGNIFICANCE
Preventive periodontal regimens for diabetic patients should be sufficiently intense and sustained to eliminate periodontal inflammation and should be closely coordinated with the patient's overall clinical diabetic management.
FORMULATION DEVELOPMENT AND EVALUATION OF FAST DISSOLVING FILM OF CINNARIZINE

Cinnarizine is a H1-anti histaminic drug which is used in motion sickness, vertigo, vomiting and in menier’s disease. These conditions require a delivery system capable of delivering the drug rapidly for immediate relief without the need of water. The films were prepared by solvent casting technique. The 3 factorial design was applied for optimization of concentration of polymer HPMC E5 and plasticizer PEG 400. The prepared films were evaluated for various parameters related to delivery system like thickness, tensile strength, % elongation, folding endurance, disintegration time, drug content, In vitro release study and stability study. From design statistical analysis, the film (batch F5) with HPMC E5 (3%) and plasticizer PEG 400 (30%) was giving low disintegration time(18 sec), sufficient strength(189±3.25) and high drug release(98.46±2.31) and better %elongation(4.32±0.82). Thus, cinnarizine film was formulated giving fast release and immediate action for motion sickness.
Intermittent balneotherapy at the Dead Sea area for patients with knee osteoarthritis.

BACKGROUND
Balneotherapy, traditionally administered during a continuous stay at the Dead Sea area, has been shown to be effective for patients suffering from knee osteoarthritis.


OBJECTIVES
To evaluate the effectiveness of an intermittent regimen of balneotherapy at the Dead Sea for patients with knee osteoarthritis.


METHODS
Forty-four patients with knee osteoarthritis were included in a prospective randomized single-blind controlled study. The patients were divided into two groups: a treatment group (n=24), which were treated twice weekly for 6 consecutive weeks in a sulfur pool heated to 35-36 degrees C, and a control group (n=20) treated in a Jacuzzi filled with tap water heated to 35-36 degrees C. Participants were assessed by the Lequesne index of osteoarthritis severity, the WOMAC index, the SF-36 quality of health questionnaire, VAS scales for pain (completed by patients and physicians), and physical examination.


RESULTS
A statistically significant improvement, lasting up to 6 months, was observed in the treatment group for most of the clinical parameters. In the control group the only improvements were in the SF-36 bodily pain scale at 6 months, the Lequesne index at 1 month and the WOMAC pain score at the end of the treatment period. Although the patients in the control group had milder disease, the difference between the two groups was not statistically significant.


CONCLUSIONS
Intermittent balneotherapy appears to be effective for patients with knee osteoarthritis.
LibGuides: 7HASS - Ancient China: Key Individuals

Learn about the world's oldest continuous civilisation and how it has influenced our world today.
CellTV—On the Benefit of TV Distribution Over Cellular Networks: A Case Study

As mobile IP-access is becoming the dominant technology for providing wireless services, the demand for more spectrum for this type of access is increasing rapidly. Since IP-access can be used for all types of services, instead of a plethora of dedicated, single-service systems, there is a significant potential to make spectrum use more efficient. In this paper, the feasibility and potential benefit of replacing the current terrestrial UHF TV broadcasting system with a mobile, cellular data (IP-) network are analyzed. In the cellular network, TV content would be provided as one of the services (CellTV). In the investigation, we consider typical Swedish rural and urban environments. We use different models for TV viewing patterns and cellular technologies as expected in the year 2020. Results of the quantitative analysis indicate that CellTV distribution can be beneficial if the TV consumption trend goes toward more specialized programming, more local contents, and more on-demand requests. Mobile cellular systems, with their flexible unicast capabilities, will be an ideal platform to provide these services. However, the results also demonstrate that CellTV is not a spectrum-efficient replacement for terrestrial TV broadcasting with current viewing patterns (i.e., a moderate number of channels with each a high numbers of viewers). In this case, it is doubtful whether the expected spectrum savings can motivate the necessary investments in upgrading cellular sites and developing advanced TV receiver required for the success of CellTV distribution.
Inductive Learning Algorithms and Representations for Text Categorization

1. ABSTRACT Text categorization – the assignment of natural language texts to one or more predefined categories based on their content – is an important component in many information organization and management tasks. We compare the effectiveness of five different automatic learning algorithms for text categorization in terms of learning speed, realtime classification speed, and classification accuracy. We also examine training set size, and alternative document representations. Very accurate text classifiers can be learned automatically from training examples. Linear Support Vector Machines (SVMs) are particularly promising because they are very accurate, quick to train, and quick to evaluate. 1.1
Transmission model of endemic human malaria in a partially immune population

A new transmission model of human malaria in a partially immune population with three discrete delays is formulated for variable host and vector populations. These are latent period in the host population, latent period in the vector population and duration of partial immunity. The results of our mathematical analysis indicate that a threshold parameterR0 exists. ForR0 > 1, the expected number of mosquitoes infected from humansRhm should be greater than a certain critical valueR∗hm or should be less thanR∗hm whenR ∗ hm > 1, for a stable endemic equilibrium to exist. We deduce from model analysis that an increase in the period within which partial immunity is lost increases the spread of the disease. Numerically we deduce that treatment of the partially immune humans assists in reducing the severity of the disease and that transmission blocking vaccines would be effective in a partially immune population. Numerical simulations support our analytical conclusions and illustrate possible behaviour scenarios of the model. c © 2007 Elsevier Ltd. All rights reserved.
Auto lead angle algorithm for high efficiency control of BLDC Motor

The Brushless DC motors are used in various industries such as home appliances, electric vehicles, Medical, Industrial automation equipment and so on. Because they have advantages of low noise, simple control and high power density. But, in a high-speed motor drive, current lagging which is induced by the impedance of the motor inductor reduces the motor efficiency. To solve this problem, we propose an auto lead angle control algorithm based on a gradient descent algorithm. With this algorithm, the motor current and motor Back-EMF have an identical phase angle. Thus, the efficiency of the motor can be increased. In order to verify the proposed algorithm, we implemented the hardware with FPGA and board including analog circuit. As a result, it was confirmed that the optimum lead angle was found with only one current value without various parameters, and the efficiency of the motor was improved. Also, it is confirmed that the efficiency is further increased at high load and high speed.
Contrast Subgraph Mining from Coherent Cores

Graph paern mining methods can extract informative and useful paerns from large-scale graphs and capture underlying principles through the overwhelmed information. Contrast analysis serves as a keystone in various elds and has demonstrated its eectiveness in mining valuable information. However, it has been long overlooked in graph paern mining. erefore, in this paper, we introduce the concept of contrast subgraph, that is, a subset of nodes that have signicantly dierent edges or edge weights in two given graphs of the same node set. emajor challenge comes from the gap between the contrast and the informativeness. Because of the widely existing noise edges in real-world graphs, the contrast may lead to subgraphs of pure noise. To avoid such meaningless subgraphs, we leverage the similarity as the cornerstone of the contrast. Specically, we rst identify a coherent core, which is a small subset of nodes with similar edge structures in the two graphs, and then induce contrast subgraphs from the coherent cores. Moreover, we design a general family of coherence and contrast metrics and derive a polynomial-time algorithm to eciently extract contrast subgraphs. Extensive experiments verify the necessity of introducing coherent cores as well as the eectiveness and eciency of our algorithm. Real-world applications demonstrate the tremendous potentials of contrast subgraph mining. ACM Reference format: Jingbo Shang1, Xiyao Shi1, Meng Jiang2, Liyuan Liu1, Timothy Hanray3, Jiawei Han1. 2018. Contrast Subgraph Mining from Coherent Cores. In Proceedings of ACM SIGKDD Conference on Knowledge Discovery and Data Mining, London, UK, August 2018 (KDD’18), 9 pages. DOI: 10.475/123 4
High definition bronchoscopy: a randomized exploratory study of diagnostic value compared to standard white light bronchoscopy and autofluorescence bronchoscopy

BACKGROUND
Videobronchoscopy is an essential diagnostic procedure for evaluation of the central airways and pivotal for the diagnosis and staging of lung cancer. Technological improvements have resulted in high definition (HD) images with advanced real time image enhancement techniques (i-scan).


OBJECTIVES
In this study we aimed to explore the sensitivity of HD+ i-scan bronchoscopy for detection of epithelial changes like vascular abnormalities and suspicious preinvasive lesions, and tumors.


METHODS
In patients scheduled for a therapeutic or diagnostic procedure under general anesthesia videos of the bronchial tree were made using 5 videobronchoscopy modes in random order: normal white light videobronchoscopy (WLB), HD-bronchoscopy (HD), HD bronchoscopy with surface enhancement technique (i-scan1), HD with surface- and tone enhancement technique (i-scan2) and dual mode autofluorescence videobronchoscopy (AFB). The videos were scored in random order by two independent and blinded expert bronchoscopists.


RESULTS
In 29 patients all videos were available for analysis. Vascular abnormalities were scored most frequently in HD + i-scan2 bronchoscopy (1.33 ± 0.29 abnormal or suspicious sites per patient) as compared to 0.12 ± 0.05 site for AFB (P = 0.003). Sites suspicious for preinvasive lesions were most frequently reported using AFB (0.74 ± 0.12 sites per patient) as compared to 0.17 ± 0.06 for both WLB and HD bronchoscopy (P = 0.003). Tumors were detected equally by all modalities. The preferred modality was HD bronchoscopy with i-scan (tone- plus surface and surface enhancement in respectively 38% and 35% of cases P = 0.006).


CONCLUSIONS
This study shows that high definition bronchoscopy with image enhancement technique may result in better detection of subtle vascular abnormalities in the airways. Since these abnormalities may be related to preneoplastic lesions and tumors this is of clinical relevance. Further investigations using this technique relating imaging to histology are warranted.
Genetic predisposition to obesity in bulimia nervosa: a mutation screen of the melanocortin-4 receptor gene

Obesity has been identified as a risk factor for the development of bulimia nervosa (BN). Accordingly, we hypothesize that genotypes predisposing to obesity can be detected in patients with this eating disorder. In order to investigate this hypothesis we screened the melanocortin-4 receptor gene (MC4R) for mutations using single strand conformation analysis in 81 female inpatients treated for BN. A single patient with both extreme obesity and BN had a haplo-insufficiency mutation in the MC4R. Comparison of current and maximal body mass index (BMI) of all patients with cross-sectionally obtained BMI in the general population revealed an age appropriate distribution for current BMI and a substantially increased frequency for overweight at time of maximal BMI. Our findings suggest that overweight is a risk factor for BN in clinically ascertained patients. For the first time a genotype predisposing to obesity has been detected in an extremely obese patient with BN.
A Swot Analysis of Instruction Sequence Theory

After 15 years of development of instruction sequence theory (IST) writing a SWOT analysis about that project is long overdue. The paper provides a comprehensive SWOT analysis of IST based on a recent proposal concerning the terminology for the theory and applications of instruction sequences.
Fighting global food price rises in the developing world: the response of China and its effect on domestic and world markets

This article addresses how China is being affected by and is responding to the world food crisis. So far, Chinese officials have responded to higher world prices by drawing down stocks and limiting exports of major grains. These policy instruments were not available for soybeans, so domestic prices of soy and other oilseeds have risen with international prices. Using a global CGE model, we show that the initial world price rise was largely due to higher world oil prices and demand for biofuels as opposed to other factors, especially in maize and soybeans. China’s response to this shock has kept domestic grain prices low relative to world grain markets and to domestic soybean prices. As grain stocks are depleted, however, demand growth will push domestic prices back into alignment. Anticipating this pressure on consumers and accelerating supply response through public investment will facilitate adjustment. JEL classification: Q11, Q18, Q42, Q43