LLukas22/scidocs huggingface dataset:
Primary central nervous system lymphoma treated with high-dose methotrexate, high-dose busulfan/thiotepa, autologous stem-cell transplantation and response-adapted whole-brain radiotherapy: results of the multicenter Ostdeutsche Studiengruppe Hamato-Onkologie OSHO-53 phase II study.

BACKGROUND
We investigated the efficacy and safety of tandem high-dose methotrexate (HD-MTX) induction followed by high-dose busulfan/thiotepa (HD-BuTT) with autologous peripheral blood stem-cell transplantation (aPBSCT) and response-adapted whole-brain radiation therapy (WBRT) in patients with newly diagnosed primary central nervous system lymphoma.


PATIENTS AND METHODS
Twenty-three patients were treated with HD-MTX on days 1 and 10. In case of at least a partial remission (PR), HD-BuTT followed by aPBSCT was given. Patients without response to induction or without complete remission (CR) after HD-BuTT received WBRT.


RESULTS
Sixteen patients received HD-MTX and HD-BuTT achieving a CR/PR rate of 69%/13%. CR/PR rates for all patients (n = 23) were 70%/13%. There were three deaths during therapy. With longer follow-up three neurotoxic deaths occurred in irradiated patients (n = 9), while no persistent neurotoxicity was seen after HD-BuTT without subsequent WBRT. At a median follow-up of 15 months (range 1-69) median event-free survival (EFS) and overall survival (OS) for all patients were 17 and 20 months (Kaplan-Meier), after HD-BuTT 27 months and "not reached", respectively. Estimated 2-year EFS and OS were 45% and 48% for all patients versus 56% and 61% for the HD-BuTT group, respectively.


CONCLUSION
MTX induction followed by HD-BuTT is an effective and very short time-on-treatment regimen. Median survival for patients treated with high-dose chemotherapy is not reached yet. The induction regimen needs optimisation. In this study WBRT was associated with a high incidence of severe neurotoxicity.
Effect of post-trochanteric groove support on stance control associated with the pelvic-lumbar system: A preliminary study.

BACKGROUND
Many stroke and neuromuscular patients with paraplegia or severe hemiparesis cannot control trunk balance.


OBJECTIVE
To support the pelvis/hip of paresis patients, a new pelvic/hip support system was developed bearing a convex pressing member placed over the post-trochanteric groove, a cutaneous landmark sited on the lateral portion of the gluteus maximus muscle and indicating the posterior aspect of the greater trochanter.


STUDY DESIGN
Preliminary study.


METHODS
Stance control differences in two paretic patients (Guillain-Barré syndrome and stroke sequelae) with or without post-trochanteric groove support were examined. The contact pressure on the post-trochanteric groove was examined in eight healthy volunteers using an impact force sensor. The pelvic-lumbar movement was also examined using three-dimensional motion analysis, and the gluteus muscles activity was evaluated using surface electromyography.


RESULTS
Without post-trochanteric groove support, total three-dimensional displacement of the sacral marker was longer in the paresis patients than in normal controls, while post-trochanteric groove support decreased this distance. Post-trochanteric groove support provided compression pressure on the post-trochanteric groove, and all subjects showed a more upright trunk position, providing more anterior pelvic tilting. Six of eight subjects showed increased lumbar lordosis. Five of eight subjects showed gluteus maximus and/or gluteus medius muscle activation.


CONCLUSION
The mechanisms of post-trochanteric groove support were suggested to be spino-pelvic coordination and gluteal muscle activation.


CLINICAL RELEVANCE
The post-trochanteric groove is a cutaneous landmark located behind the pelvis/hip joint. Applying pressure to the post-trochanteric groove from behind pushes the trunk to adopt a more upright position, leading to improved stance control. Underlining mechanisms appear to be spino-pelvic coordination and gluteal muscle activation.
Phenolics compounds , flavonoids and antioxidant activity of chia seed extracts ( Salvia hispanica ) obtained by different extraction conditions

This study aimed to chemically characterize the chia seed (Salvia hispanica), get chia seed extracts at different concentrations of ethanol and temperature using a factorial design 22 with triplicate at the central point and then analyze the extracts the content phenolics, flavonoids and antioxidant activity in vitro. The results showed that the chia seed has a high content of dietary fiber (374.4 g/kg), lipids (283.5 g/kg) and protein (231.7 g/kg). The same possess antioxidant activity, and the extract with a higher antioxidant activity was obtained by the method of stirring using temperatures of 600C and 80% ethanol concentrations. The content of phenolic compounds was found to be 2,639 g of gallic acid equivalent/kg of dry sample. The flavonoid content was 0.162 g equivalent of quercetin/kg dry sample. The IC50 found was of 3.841 mg/mL and FRAP 45.004 mmol trolox equivalent/ kg of dry sample.
Design and implementation of n-scroll chaotic attractors from a general jerk circuit

This paper proposes a novel nonlinear modulating function approach for generating n-scroll chaotic attractors based on a general jerk circuit. The systematic nonlinear modulating function methodology developed here can arbitrarily design the swings, widths, slopes, breakpoints, equilibrium points, shapes, and even the general phase portraits of the n-scroll chaotic attractors by using the adjustable sawtooth wave, triangular wave, and transconductor wave functions. The dynamic mechanism and chaos generation condition of the general jerk circuit are further investigated by analyzing the system stability. A simple block circuit diagram, including integrator, sawtooth wave and triangular wave generators, buffer, switch linkages, and voltage-current conversion resistors, is designed for the hardware implementations of various 3-12-scroll chaotic attractors via switchings of the switch linkages. This is the first time to experimentally verify a 12-scroll chaotic attractor generated by an analog circuit. In particular, the recursive formulas of system parameters and real physical circuit parameters are rigorously derived for the hardware implementations of the n-scroll chaotic attractors. Moreover, the adjustability of the nonlinear modulating function and the rigorous recursive formulas together provide a theoretical principle for the hardware implementations of various chaotic attractors with a large number of scrolls.
Functional neuroanatomy of visual masking deficits in schizophrenia.

CONTEXT
Visual masking procedures assess the earliest stages of visual processing. Patients with schizophrenia reliably show deficits on visual masking, and these procedures have been used to explore vulnerability to schizophrenia, probe underlying neural circuits, and help explain functional outcome.


OBJECTIVE
To identify and compare regional brain activity associated with one form of visual masking (ie, backward masking) in schizophrenic patients and healthy controls.


DESIGN
Subjects received functional magnetic resonance imaging scans. While in the scanner, subjects performed a backward masking task and were given 3 functional localizer activation scans to identify early visual processing regions of interest (ROIs).


SETTING
University of California, Los Angeles, and the Department of Veterans Affairs Greater Los Angeles Healthcare System.


PARTICIPANTS
Nineteen patients with schizophrenia and 19 healthy control subjects. Main Outcome Measure The magnitude of the functional magnetic resonance imaging signal during backward masking.


RESULTS
Two ROIs (lateral occipital complex [LO] and the human motion selective cortex [hMT+]) showed sensitivity to the effects of masking, meaning that signal in these areas increased as the target became more visible. Patients had lower activation than controls in LO across all levels of visibility but did not differ in other visual processing ROIs. Using whole-brain analyses, we also identified areas outside the ROIs that were sensitive to masking effects (including bilateral inferior parietal lobe and thalamus), but groups did not differ in signal magnitude in these areas.


CONCLUSIONS
The study results support a key role in LO for visual masking, consistent with previous studies in healthy controls. The current results indicate that patients fail to activate LO to the same extent as controls during visual processing regardless of stimulus visibility, suggesting a neural basis for the visual masking deficit, and possibly other visual integration deficits, in schizophrenia.
What Good are Statistics that Don’t Generalize?:

Quantitative and qualitative inquiry are sometimes portrayed as distinct and incompatible paradigms for research in education. Approaches to combining qualitative and quantitative research typically " integrate " the two methods by letting them co-exist independently within a single research study. Here we describe intra-sample statistical analysis (ISSA) as a general technique for using quantitative tools to support qualitative inquiry so as to simultaneously provide warrants from qualitative and quantitative traditions. In certain circumstances ISSA makes it possible to relax the requirement that individual participants be treated as the unit of analysis in statistical models, and thus provides justification for coding qualitative observations and drawing statistically based conclusions about observations in a qualitative context. We developed ISSA and describe it here both because it can be used as a tool for qualitative research, and because it illuminates the relationship between method and interpretation in the research traditions that it bridges. In this article, we (a) summarize key features of qualitative and quantitative research relevant to ISSA; (b) describe ISSA as an analytical technique; (c) discuss the quantitative and qualitative justification for ISSA and the nature of the conclusions that can be drawn based on it; and (d) explore the more general implications of ISSA for qualitative and quantitative inquiry. T hough written about a border skirmish in the " Great Game " of colonial power at the end of the 19th century, these lines from Kipling's " The Ballad of East and West " aptly describe the current schism in education research method-ologies. Some have declared the end of the " paradigm wars " between qualitative and quantitative methods (Tashakkori & Teddlie, 1998, p. 1), but debates about the comparative validity and utility of research traditions 1 continue, not least in recent critical reports about the nature of education research (e.g., National Research Council, 2002). The persistence of methodological divisions is hardly surprising. Although qualitative research and quantitative research are really collections of loosely related methods and associated techniques rather than natural categories, substantive differences do exist between them. These differences result , ultimately, from differing perspectives on the nature of fundamental and problematic concepts such as " truth " and " understanding , " on the kinds of claims that are worth making, and on the kinds of warrants required in scholarly inquiry. The lines that follow Kipling's oft-quoted description of worldviews in conflict are less well known, but are …
Experimental Investigation And Optimization Of Machining Parameters For Surface Roughness In CNC Turning By Taguchi Method

Medium Carbon Steel AISI 1045 has a wide variety of applications in vehicle component parts & machine building industry. Surface roughness is the main quality function in high speed turning of medium carbon steel in dry conditions. In this study, the effect and optimization of machining parameters (cutting speed, feed rate and depth of cut) on surface roughness is investigated. An L’27 orthogonal array, analysis of variance (ANOVA) and the signal-to-noise (S/N) ratio are used in this study. Three levels of machining parameters are used and experiments are done on STALLION-100 HS CNC lathe. The optimum value of the surface roughness (Ra) comes out to be 0.89. It is also concluded that feed rate is the most significant factor affecting surface roughness followed by depth of cut. Cutting speed is the least significant factor affecting surface roughness. Optimum results are finally verified with the help of confirmation experiments.
A multicentre, randomized, placebo- and active-controlled trial comparing the efficacy and safety of topical ketoprofen in Transfersome gel (IDEA-033) with ketoprofen-free vehicle (TDT 064) and oral celecoxib for knee pain associated with osteoarthritis.

OBJECTIVE
To assess the efficacy and safety of 12-week treatment with ketoprofen in ultradeformable phospholipid vesicles in patients with OA knee pain and to compare the efficacy with that of ketoprofen-free vehicle and celecoxib. METHODS; A multicentre, double-blind controlled study in which patients with knee OA and moderate pain were randomized to one of the six arms: topical ketoprofen 50 or 100 mg in ultradeformable vesicles (IDEA-033), 2.2 or 4.4 g ketoprofen-free vehicle (TDT 064), oral celecoxib 100 mg or matching oral placebo, all bd. The primary outcome was change from baseline in the WOMAC pain subscale at week 12.


RESULTS
A total of 1395 patients received treatment. Baseline mean WOMAC pain scores ranged from 4.7 to 4.8 across groups. The mean reduction in WOMAC pain score at week 12 was -1.9 (-40.8%) for ketoprofen 50 mg, -1.9 (-40.9%) for ketoprofen 100 mg, -1.9 (-39.8%) for 2.2 g TDT 064, -1.8 (-37.8%) for 4.4 g TDT 064, -1.9 (-40.4%) for celecoxib and -1.4 (-29.3%) for oral placebo. IDEA-033 was not statistically superior to TDT 064. All topical treatments were statistically superior to oral placebo and non-inferior to celecoxib. The most frequent types of treatment-related adverse events reported were gastrointestinal for oral (15.9% for celecoxib) and dermal for topical applications (12.2% for ketoprofen 100 mg).


CONCLUSION
IDEA-033 was not superior to ketoprofen-free vehicle, but both formulations were superior to oral placebo and non-inferior to celecoxib in reducing OA knee pain.


TRIAL REGISTRATION
ClinicalTrials.gov, http://clinicaltrials.gov/, NCT00716547.
Critical Skills of IS Professionals: A Model for Curriculum Development

Executive Summary In the rapidly changing field of Information Systems, educational programs must be continually reevaluated and revised. This can be a daunting task. To make this process more manageable and to create programs that more accurately reflect the demands of the marketplace, a curriculum revision process is presented. As part of the curriculum revision process, a study was conducted to determine the expected skills and knowledge required for Information Systems professionals in three general staffing groups: programmers, analysts, and end-user support. A survey instrument was developed asking respondents to rate the importance of each knowledge/skill area three years from now for each of the staffing groups. The results show that Information Systems knowledge relating to the entire organization and overall business knowledge will be important with less emphasis on advanced IS applications. The so-called ‘soft skills’ such as teamwork and collaboration, planning and leading projects, presentation delivery, and writing skills will be critical for success in the Information Systems profession. More importance will be placed on web-based languages rather than more traditional languages such as COBOL. Based on the analysis, a skills matrix is presented that can be used as a foundation for developing courses. This paper also describes a curriculum development model that can be used as a guide for curriculum revision.
Single-photon entanglement concentration for long-distance quantum communication

We present a single-photon entanglement concentration protocol for long-distance quantum communication with quantum nondemolition detector. It is the first concentration protocol for singlephoton entangled states and it dose not require the two parties of quantum communication to know the accurate information about the coefficient α and β of the less entangled states. Also, it does not resort to sophisticated single-photon detectors, which makes this protocol more feasible in current experiments. Moreover, it can be iterated to get a higher efficiency and yield. All these advantages maybe make this protocol have more practical applications in long-distance quantum communication and quantum internet.
The Dark Triad : Facilitating a Short-Term Mating Strategy in Men

This survey (N1⁄4 224) found that characteristics collectively known as the Dark Triad (i.e. narcissism, psychopathy and Machiavellianism) were correlated with various dimensions of short-term mating but not long-term mating. The link between the Dark Triad and shortterm mating was stronger for men than for women. The Dark Triad partially mediated the sex difference in short-term mating behaviour. Findings are consistent with a view that the Dark Triad facilitates an exploitative, short-term mating strategy in men. Possible implications, including that Dark Triad traits represent a bundle of individual differences that promote a reproductively adaptive strategy are discussed. Findings are discussed in the broad context of how an evolutionary approach to personality psychology can enhance our understanding of individual differences. Copyright # 2008 John Wiley & Sons, Ltd.
Conceptual mathematics - a first introduction to categories

In the last 60 years, the use of the notion of category has led to a remarkable unification and simplification of mathematics. Conceptual Mathematics, He proposed elementary book is presented, in history of mathematics diverse areas. While the notion of 'category' for this book club lawvere and to satisfy. I read over the 2nd edition's first book to satisfy are also. Stephen but rather develops from the first.
Pragmatist Contributions to the Study of Public Involvement in Controversy

discursivist analysis of the role of 'issue framing' in the involvement of publics in politics.
Short-Term Effectiveness of Web-Based Guided Self-Help for Phobic Outpatients: Randomized Controlled Trial

BACKGROUND
Internet-based guided self-help has been successfully used in the general population, but it is unknown whether this method can be effectively used in outpatient clinics for patients waiting for face-to-face psychotherapy for phobias.


OBJECTIVE
The aim was to assess the clinical effectiveness of Phobias Under Control, an Internet-based intervention based on exposure therapy with weekly guidance.


METHODS
We conducted a randomized controlled trial, recruiting 212 outpatients scheduled to receive face-to-face psychotherapy for any type of phobia at an outpatient clinic. Participants suffering from at least 1 DSM-IV or ICD-10 classified phobia (social phobia, agoraphobia with or without panic disorder, and/or specific phobia as ascertained by a telephone interview at baseline) were randomly allocated to either a 5-week Internet-based guided self-help program based on exposure therapy with weekly student support followed by face-to-face psychotherapy (n=105) or a wait-list control group followed by face-to-face psychotherapy (n=107). Primary outcome was the Fear Questionnaire (FQ). Secondary outcomes were the Beck Anxiety Inventory (BAI) and Center of Epidemiological Studies-Depression scale (CES-D). Assessments took place by telephone at baseline (T0) and on the Internet at posttest (T1, self-assessment at 5 weeks after baseline). Missing data at T1 were imputed.


RESULTS
At posttest, analysis of covariance on the intention-to-treat sample showed significant but small effect sizes between intervention and control groups on the FQ (d=0.35, P=.02), CES-D (d=0.34, P=.03), and a nonsignificant effect size on the BAI (d=0.28. P=.05). Although initial acceptance was good, high nonresponse was observed, with 86 of 212 participants (40.5%) lost to follow-up at T1 and only 14 of 105 (13.3%) intervention participants finishing all 5 weeks.


CONCLUSIONS
Phobias Under Control is modestly effective in lowering phobic and depressive symptoms in a relatively short period and may be clinically beneficial when implemented in routine outpatient practice.


TRIAL REGISTRATION
Netherlands Trial Register NTR2233; http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=2233 (Archived by WebCite at http://www.webcitation.org/6O2ioOQSs).
Prediction of shear strength of reinforced concrete beams using adaptive neuro-fuzzy inference system and artificial neural network

Reinforced concrete beam; Shear strength; Artificial neural network; Adaptive neuro-fuzzy inference system; Iranian concrete institute code; American concrete institute code. Abstract In this paper, the Artificial Neural Network (ANN) and the Adaptive Neuro-Fuzzy Inference System (ANFIS) are used to predict the shear strength of Reinforced Concrete (RC) beams, and the models are compared with American Concrete Institute (ACI) and Iranian Concrete Institute (ICI) empirical codes. The ANN model, with Multi-Layer Perceptron (MLP), using a Back-Propagation (BP) algorithm, is used to predict the shear strength of RC beams. Six important parameters are selected as input parameters including: concrete compressive strength, longitudinal reinforcement volume, shear span-to-depth ratio, transverse reinforcement, effective depth of the beam and beam width. The ANFIS model is also applied to a database and results are compared with the ANN model and empirical codes. The first-order Sugeno fuzzy is used because the consequent part of the Fuzzy Inference System (FIS) is linear and the parameters can be estimated by a simple least squares error method. Comparison between the models and the empirical formulas shows that the ANN model with the MLP/BP algorithm provides better prediction for shear strength. In adition, ANN and ANFIS models are more accurate than ICI and ACI empirical codes in prediction of RC beams shear strength. © 2012 Sharif University of Technology. Production and hosting by Elsevier B.V. All rights reserved.
The state of Darwinian theory

The year 2009 marked both the bicentenary of Charles Darwin’s birth, and the passage of 150 years since the publication of his revolutionary book, commonly referred to as The Origin of Species (Darwin 1859). As part of the national celebrations that took place in the UK, a meeting on ‘Mathematical Models in Ecology and Evolution’ was held in Bristol on September 10 and 11, with a special focus on the mathematical modelling and application of Darwin’s key theories. This special issue collects together selected papers presented at the meeting, including contributions by the four invited keynote speakers, Rob Boyd, A. W. F. Edwards, Hanna Kokko and Franjo Weissing, as well as papers received after the event. The topics of these papers span the modelling of a very wide range of Darwin’s ideas, particularly evolution through natural selection, the origin of species, sexual selection, altruism and cooperation, and pangenesis, as well as applications of Darwinian thinking to the behaviour of animals, humans, and even human societies. It is hoped that this collection of papers will provide a useful snapshot of the state-of-the-art in Darwinian theory after the last one and a half centuries, and help to identify potential directions for research over the next.