LLukas22/scidocs huggingface dataset:
An sEMG-based method to adaptively reject the effect of contraction on spectral analysis for fatigue tracking

Muscle fatigue detection and tracking has gained significant attention as the sports science and rehabilitation technologies developed. It is known that muscle fatigue can be evaluated through surface Electromyography (sEMG) sensors, which are portable, non-invasive and applicable for real-time systems. There are plenty of fatigue tracking algorithms, many of which uses frequency, time and time-frequency behaviors of sEMG signals. An example to most commonly used sEMG-based fatigue detection methods can be mean frequency (MNF), median frequency (MDF), zero-crossing rate (ZCR) and continuous wavelet transform (CWT). However, all of these muscle fatigue calculation methods are adversely affected by the dynamically changing sEMG contraction amplitude, since EMG spectrum also demonstrates a shift with the changing signal RMS; powerful contractions lead a shift to high frequency bounds and the opposite happens for the weak. To overcome that, we propose an adaptive algorithm, which learns the effect of contraction power on sEMG power spectral density (PSD) and subtracts that amount of frequency shift from the PSD.
Metasurface holograms for visible light

Holography, a revolutionary 3D imaging technique, has been developed for storing and recovering the amplitude and phase of light scattered by objects. Later, single-beam computer-generated phase holography was proposed for restoring the wavefront from a given incidence. However, because the phase modulation depends on the light propagation inside the material, the thickness of phase holograms usually remains comparable to the wavelength. Here we experimentally demonstrate ultra-thin metasurface holograms that operate in the visible range whose thickness is only 30 nm (approximately 1/23 of the operational wavelength). To our knowledge, this is the thinnest hologram that can provide both amplitude and phase modulation in the visible wavelength range, which generates highresolution low-noise images. Using this technique, not only the phase, but potentially the amplitude of the incident wave can be efficiently controlled, expanding the route to new applications of ultra-thin and surface-confined photonic devices. DOI: 10.1038/ncomms3807
Association between thyroid autoantibodies and miscarriage and preterm birth: meta-analysis of evidence

OBJECTIVES
To evaluate the association between thyroid autoantibodies and miscarriage and preterm birth in women with normal thyroid function. To assess the effect of treatment with levothyroxine on pregnancy outcomes in this group of women.


DESIGN
Systematic review and meta-analysis.


DATA SOURCES
Medline, Embase, Cochrane Library, and SCISEARCH (inception-2011) without any language restrictions. We used a combination of key words to generate two subsets of citations, one indexing thyroid autoantibodies and the other indexing the outcomes of miscarriage and preterm birth.


STUDY SELECTION
Studies that evaluated the association between thyroid autoantibodies and pregnancy outcomes were selected in a two stage process. Two reviewers selected studies that met the predefined and explicit criteria regarding population, tests, and outcomes.


DATA SYNTHESIS
Odds ratios from individual studies were pooled separately for cohort and case-control studies with the random effects model.


RESULTS
30 articles with 31 studies (19 cohort and 12 case-control) involving 12,126 women assessed the association between thyroid autoantibodies and miscarriage. Five studies with 12,566 women evaluated the association with preterm birth. Of the 31 studies evaluating miscarriage, 28 showed a positive association between thyroid autoantibodies and miscarriage. Meta-analysis of the cohort studies showed more than tripling in the odds of miscarriage with the presence of thyroid autoantibodies (odds ratio 3.90, 95% confidence interval 2.48 to 6.12; P < 0.001). For case-control studies the odds ratio for miscarriage was 1.80, 1.25 to 2.60; P = 0.002). There was a significant doubling in the odds of preterm birth with the presence of thyroid autoantibodies (2.07, 1.17 to 3.68; P = 0.01). Two randomised studies evaluated the effect of treatment with levothyroxine on miscarriage. Both showed a fall in miscarriage rates, and meta-analysis showed a significant 52% relative risk reduction in miscarriages with levothyroxine (relative risk 0.48, 0.25 to 0.92; P=0.03). One study reported on the effect of levothyroxine on the rate of preterm birth, and noted a 69% relative risk reduction (0.31, 0.11 to 0.90).


CONCLUSION
The presence of maternal thyroid autoantibodies is strongly associated with miscarriage and preterm delivery. There is evidence that treatment with levothyroxine can attenuate the risks.
Getting the Balance Right: A randomised controlled trial of physiotherapy and Exercise Interventions for ambulatory people with multiple sclerosis

BACKGROUND
People with Multiple Sclerosis have a life long need for physiotherapy and exercise interventions due to the progressive nature of the disease and their greater risk of the complications of inactivity. The Multiple Sclerosis Society of Ireland run physiotherapy, yoga and exercise classes for their members, however there is little evidence to suggest which form of physical activity optimises outcome for people with the many and varied impairments associated with MS.


METHODS AND DESIGN
This is a multi-centre, single blind, block randomised, controlled trial. Participants will be recruited via the ten regional offices of MS Ireland. Telephone screening will establish eligibility and stratification according to the mobility section of the Guys Neurological Disability Scale. Once a block of people of the same strand in the same geographical region have given consent, participants will be randomised. Strand A will concern individuals with MS who walk independently or use one stick to walk outside. Participants will be randomised to yoga, physiotherapy led exercise class, fitness instructor led exercise class or to a control group who don't change their exercise habits.Strand B will concern individuals with MS who walk with bilateral support or a rollator, they may use a wheelchair for longer distance outdoors. Participants will be randomised to 1:1 Physiotherapist led intervention, group intervention led by Physiotherapist, group yoga intervention or a control group who don't change their exercise habits. Participants will be assessed by physiotherapist who is blind to the group allocation at week 1, week 12 (following 10 weeks intervention or control), and at 12 week follow up. The primary outcome measure for both strands is the Multiple Sclerosis Impact Scale. Secondary outcomes are Modified Fatigue Impact Scale, 6 Minute Walk test, and muscle strength measured with hand held dynamometry. Strand B will also use Berg Balance Test and the Modified Ashworth Scale. Confounding variables such as sensation, coordination, proprioception, range of motion and other impairments will be recorded at initial assessment.


DISCUSSION
Data analysis will analyse change in each group, and the differences between groups. Sub group analysis may be performed if sufficient numbers are recruited.


TRIAL REGISTRATION
ISRCTN77610415.
Transient contrast encephalopathy after carotid angiography mimicking diffuse subarachnoid haemorrhage

Neurotoxicity caused by intraarterial injection of low-dose low osmolar, iodinated contrast agents during radiologic studies is an extremely rare adverse event. Contrast medium induced disruption of the blood–brain barrier and a direct neurotoxic effect by contrast media have been proposed as a potential mechanism of neurotoxicity. This report describes an unusual case of transient neurotoxicity following diagnostic angiography mimicking clinically and radiologically subarachnoid hemorrhage. The patient recovered without any intervention after 4 days of conservative treatment.
A double-blind randomized study assessing safety and efficacy following one-year adjunctive treatment with bitopertin, a glycine reuptake inhibitor, in Japanese patients with schizophrenia

BACKGROUND
Bitopertin, a glycine reuptake inhibitor, was investigated as a novel treatment for schizophrenia. We report all the results of a double-blind randomized study assessing safety and efficacy following 52-week adjunctive treatment with bitopertin in Japanese patients with schizophrenia.


METHODS
This study enrolled Japanese outpatients with schizophrenia who met criteria for either "negative symptoms", i.e., patients with persistent, predominant negative symptoms of schizophrenia even after long-term treatment with antipsychotics or "sub-optimally controlled symptoms", i.e., patients with insufficiently improved symptoms of schizophrenia even after long-term treatment with antipsychotics, respectively. One hundred sixty-one patients were randomly assigned to receive 52-week treatments with bitopertin doses of 5, 10, or 20 mg/day at ratio of 1:5:5, where existing antipsychotics were concomitantly administered. Efficacy endpoints included Positive and Negative Syndrome Scale (PANSS), Clinical Global Impression (CGI), and Personal and Social Performance (PSP). The purpose of the present study is primarily to evaluate the safety, and secondarily to investigate the clinical efficacy of bitopertin.


RESULTS
One hundred fourteen patients (71 %) completed 52-week treatment with bitopertin. Most of the adverse events were mild or moderate in their severity. The patients in the 20-mg group experienced more adverse events than the patients in the other two groups. Common dose-dependent adverse events were somnolence and insomnia associated with worsening schizophrenia. The blood hemoglobin levels gradually decreased from baseline in a dose-dependent manner, but there were no patients with the decrease below 10 g/dL that would have led to their discontinuation. All the efficacy endpoints gradually improved in all the treatment groups for both of the two symptoms, while there were no clear differences among the three dose groups.


CONCLUSIONS
Altogether, bitopertin was found to be generally safe and well-tolerated for the treatment of patients with schizophrenia. All three bitopertin treated groups showed improvements in all the efficacy endpoints for both of the two symptoms, i.e., "negative symptoms" and "sub-optimally controlled symptoms", throughout the duration of the study.


TRIAL REGISTRATION
Japan Pharmaceutical Information Center, number JapicCTI-111627 (registered on September 20, 2011).
Feature Weighting for Lazy Learning Algorithms

Learning algorithms diier in the degree to which they process their inputs prior to their use in performance tasks. Many algorithms eagerly compile input samples and use only the compilations to make decisions. Others are lazy: they perform less precompilation and use the input samples to guide decision making. The performance of many lazy learners signiicantly degrades when samples are deened by features containing little or misleading information. Distinguishing feature relevance is a critical issue for these algorithms, and many solutions have been developed that assign weights to features. This chapter introduces a cat-egorization framework for feature weighting approaches used in lazy similarity learners and brieey surveys some examples in each category. 1.1 INTRODUCTION Lazy learning algorithms are machine learning algorithms (Mitchell, 1997) that are welcome members of procrastinators anonymous. Purely lazy learners typically display the following characteristics (Aha, 1997): 1. Defer: They delay the processing of their inputs until they receive requests for information; they simply store their inputs for future use. 2. Demand-Driven: They reply to information queries by combining information from their stored (e.g., training) samples. 3. Discard: They delete the constructed query and any intermediate results. In contrast, eager algorithms greedily replace their inputs with an abstraction (e.g., a rule set, decision tree, or neural network) and use it to process queries.
Randomized pilot trial of intensive management of blood pressure or volume expansion in subarachnoid hemorrhage (IMPROVES).

BACKGROUND
Volume expansion and hypertension are widely used for the hemodynamic management of patients with subarachnoid hemorrhage.


OBJECTIVE
To investigate the feasibility, adherence, and retention in a trial of volume expansion and blood pressure manipulation to prevent delayed cerebral ischemia.


METHODS
A randomized pilot trial using a 2-way factorial design allocating patients within 72 hours of subarachnoid hemorrhage to either normovolemia (NV) or volume expansion (HV) and simultaneously to conventional (CBP) or augmented blood pressure (ABP) for 10 days. The study endpoints were protocol adherence and retention to follow-up. The quality of endpoints for a larger trial were 6-month modified Rankin Scale score, comprehensive neurobehavioral assessment, delayed cerebral ischemia, new stroke, and discharge disposition.


RESULTS
Twenty patients were randomized and completed follow-up. The overall difference in daily mean intravenous fluid intake was 2099 mL (95% confidence interval [CI]: 867, 3333), HV vs NV group. The overall mean systolic blood pressure difference was 5 mm Hg (95% CI: -4.65, 14.75), ABP vs CBP group. Adverse events included death (n=1), delayed cerebral ischemia (n=1), and pulmonary complications (n=3). There were no differences in modified Rankin Scale score between HV and NV (difference 0.1; 95% CI: -1.26, 1.46, P=.87) or between ABP and CBP groups (-0.5, 95% CI: -1.78, 0.78, P=.43). Neuropsychological scores were similar between HV vs NV, but tended to be worse in ABP (57±27) vs CBP group (85±21, P=.04).


CONCLUSION
This pilot study showed adequate feasibility and excellent retention to follow-up. Given the suggestion of possible worse neurobehavioral outcome with ABP, a larger trial to determine the optimal blood pressure management in this patient population is warranted. (ClinTrials.gov NCT01414894.)
Wearable power assist device for hand grasping using pneumatic artificial rubber muscle

The purpose of this study is to develop a wearable power assist device for hand grasping in order to support activity of daily living (ADL) safely and easily. In this paper, the mechanism of the developed power assist device is described, and then the effectiveness of this device is discussed experimentally.
A combination of brain-computer interaction and eye tracking paradigmes for multimodal interaction

This study evaluates the usability and efficiency of three multimodal combinations of Brain-Computer Interfaces (BCI) and Eye-tracking in the context of a simple puzzle game involving tile selections and rotations. Results indicate that although BCI interaction raises interest is still very tiring and imprecise. However, BCI based on SSVEP are efficient in cooperation with gaze.
Increased 5-HT release mediates the anxiogenic response during benzodiazepine withdrawal: a review of supporting neurochemical and behavioural evidence

This paper reviews the biochemical and behavioural evidence that the increased anxiety that occurs during benzodiazepine withdrawal is caused by increased 5-HT activity. In hippocampal slices taken from rats withdrawn for 24 h from chronic diazepam treatment (2 mg/kg/day for 21 days) there was a significant increase in K+-evoked release of [3H]5-HT and in45Ca2+ uptake and both of these changes were reversed by the GABAB agonist, baclofen. Baclofen also reversed the anxiogenic response that is detected on withdrawal from chronic diazepam treatment. Other drugs that reduce 5-HT function (tianeptine which increases 5-HT uptake; buspirone, a 5-HT1A receptor agonist/partial agonist; zacopride, a 5-HT3 receptor antagonist) also reversed this anxiogenic response. Finally, we present data from a group of rats that did not develop tolerance to the anxiolytic effects of diazepam (2 mg/kg), even after 5 weeks treatment. This group failed to show an anxiogenic response on withdrawal from diazepam, nor was there an increase in hippocampal 5-HT release. We discuss the extent to which increased hippocampal 5-HT release can be causally linked to the increased anxiety during benzodiazepine withdrawal.
Software performance testing using covering arrays: efficient screening designs with categorical factors

Classical Design of Experiment (DOE) techniques have been in use for many years to aid in the performance testing of systems. In particular fractional factorial designs have been used in cases with many numerical factors to reduce the number of experimental runs necessary. For experiments involving categorical factors, this is not the case; experimenters regularly resort to exhaustive (full factorial) experiments. Recently, D-optimal designs have been used to reduce numbers of tests for experiments involving categorical factors because of their flexibility, but not necessarily because they can closely approximate full factorial results. In commonly used statistical packages, the only generic alternative for reduced experiments involving categorical factors is afforded by optimal designs. The extent to which D-optimal designs succeed in estimating exhaustive results has not been evaluated, and it is natural to determine this. An alternative design based on covering arrays may offer a better approximation of full factorial data. Covering arrays are used in software testing for accurate coverage of interactions, while D-optimal and factorial designs measure the amount of interaction. Initial work involved exhaustive generation of designs in order to compare covering arrays and D-optimal designs in approximating full factorial designs. In that setting, covering arrays provided better approximations of full factorial analysis, while ensuring coverage of all small interactions. Here we examine commercially viable covering array and D-optimal design generators to compare designs. Commercial covering array generators, while not as good as exhaustively generated designs, remain competitive with D-optimal design generators.
Incidence trends for human papillomavirus-related and -unrelated oral squamous cell carcinomas in the United States.

PURPOSE
To investigate the impact of human papillomavirus (HPV) on the epidemiology of oral squamous cell carcinomas (OSCCs) in the United States, we assessed differences in patient characteristics, incidence, and survival between potentially HPV-related and HPV-unrelated OSCC sites.


PATIENTS AND METHODS
Data from nine Surveillance, Epidemiology, and End Results program registries (1973 to 2004) were used to classify OSCCs by anatomic site as potentially HPV-related (n = 17,625) or HPV-unrelated (n = 28,144). Joinpoint regression and age-period-cohort models were used to assess incidence trends. Life-table analyses were used to compare 2-year overall survival for HPV-related and HPV-unrelated OSCCs.


RESULTS
HPV-related OSCCs were diagnosed at younger ages than HPV-unrelated OSCCs (mean ages at diagnosis, 61.0 and 63.8 years, respectively; P < .001). Incidence increased significantly for HPV-related OSCC from 1973 to 2004 (annual percentage change [APC] = 0.80; P < .001), particularly among white men and at younger ages. By contrast, incidence for HPV-unrelated OSCC was stable through 1982 (APC = 0.82; P = .186) and declined significantly during 1983 to 2004 (APC = -1.85; P < .001). When treated with radiation, improvements in 2-year survival across calendar periods were more pronounced for HPV-related OSCCs (absolute increase in survival from 1973 through 1982 to 1993 through 2004 for localized, regional, and distant stages = 9.9%, 23.1%, and 18.6%, respectively) than HPV-unrelated OSCCs (5.6%, 3.1%, and 9.9%, respectively). During 1993 to 2004, for all stages treated with radiation, patients with HPV-related OSCCs had significantly higher survival rates than those with HPV-unrelated OSCCs.


CONCLUSION
The proportion of OSCCs that are potentially HPV-related increased in the United States from 1973 to 2004, perhaps as a result of changing sexual behaviors. Recent improvements in survival with radiotherapy may be due in part to a shift in the etiology of OSCCs.
Tools for healthy tribes: improving access to healthy foods in Indian country.

There is growing recognition that policymakers can promote access to healthy, affordable foods within neighborhoods, schools, childcare centers, and workplaces. Despite the disproportionate risk of obesity and type 2 diabetes among American Indian children and adults, comparatively little attention has been focused on the opportunities tribal policymakers have to implement policies or resolutions to promote access to healthy, affordable foods. This paper presents an approach for integrating formative research into an action-oriented strategy of developing and disseminating tribally led environmental and policy strategies to promote access to and consumption of healthy, affordable foods. This paper explains how the American Indian Healthy Eating Project evolved through five phases and discusses each phase's essential steps involved, outcomes derived, and lessons learned. Using community-based participatory research and informed by the Social Cognitive Theory and ecologic frameworks, the American Indian Healthy Eating Project was started in fall 2008 and has evolved through five phases: (1) starting the conversation; (2) conducting multidisciplinary formative research; (3) strengthening partnerships and tailoring policy options; (4) disseminating community-generated ideas; and (5) accelerating action while fostering sustainability. Collectively, these phases helped develop and disseminate Tools for Healthy Tribes-a toolkit used to raise awareness among participating tribal policymakers of their opportunities to improve access to healthy, affordable foods. Formal and informal strategies can engage tribal leaders in the development of culturally appropriate and tribe-specific sustainable strategies to improve such access, as well as empower tribal leaders to leverage their authority toward raising a healthier generation of American Indian children.
A proposal of curriculum for a Master of Electronics Engineering at the University of La Laguna

This work presents the curriculum of the Master's Degree in Electronics Engineering (MDEE) that will be submitted to the competent bodies of the University of La Laguna, as a proposal for a new MDEE that complies with current Spanish regulations.
Adherence to recommended medical regimens in childhood and adolescence.

OBJECTIVE
Factors that appear to influence treatment adherence among adults have been the focus of considerable research in recent years. However, less research has focused on children's treatment adherence. This paper reviews current knowledge about factors that appear to influence adherence among children and adolescents.


METHODOLOGY
Factors associated with adherence to medical regimens reviewed here include: (i) the psychosocial characteristics of children and their parents; (ii) the nature of the treatment regimen; and (iii) the relationship between health practitioners, parents and paediatric patients.


CONCLUSIONS
Issues for future research include: (i) the adherence of both children and their parents to children's treatment, and the allocation of responsibility for treatment adherence; (ii) the wide range of behaviours involved in regimen adherence should be acknowledge; patients' adherence to one aspect of their regimen should not be considered indicative of their overall adherence; and (iii) longitudinal studies are required to examine the causal relations between patient adherence and its antecedents.