LLukas22/scidocs huggingface dataset:
Selected symptoms associated with sexual and physical abuse history among female patients with gastrointestinal disorders: the impact on subsequent health care visits.

BACKGROUND
Despite a growing literature pointing to the deleterious health effects of sexual and physical abuse history, few studies provide evidence about which medical symptoms are most affected. The aim of this paper is to determine the impact of sexual and physical abuse history on a selected set of medical symptoms, and to test how such abuse, medical symptoms and functional disability may affect subsequent health care visits.


METHODS
We studied 239 women from a referral-based gastroenterology clinic; follow-up data were available on 196 of these women. All women were interviewed about sexual and physical abuse history.


RESULTS
Women with abuse history, particularly those with severe abuse, were much more likely to report somatic symptoms related to panic (e.g. palpitations, numbness, shortness of breath), depression (e.g. difficulty sleeping, loss of appetite), musculoskeletal disorders (e.g. headaches, muscle aches), genito-urinary disorders (e.g. vaginal discharge, pelvic pain, painful intercourse), skin disturbance (e.g. rash) and respiratory illness (e.g. stuffy nose). Furthermore, we found that the severity of abuse history, somatic symptoms and functional disability predicted 30% of the variance in health care visits during the subsequent year, and that the effect of abuse severity on visits was explained by abused women having more somatic symptoms and functional disability.


CONCLUSIONS
Patients' reports of abuse history, somatic symptoms and functional disability appear to be important factors in explaining the number of health care visits among a clinic sample of women with gastrointestinal disorders.
Alcohol and sleep I: effects on normal sleep.

This review provides a qualitative assessment of all known scientific studies on the impact of alcohol ingestion on nocturnal sleep in healthy volunteers. At all dosages, alcohol causes a reduction in sleep onset latency, a more consolidated first half sleep and an increase in sleep disruption in the second half of sleep. The effects on rapid eye movement (REM) sleep in the first half of sleep appear to be dose related with low and moderate doses showing no clear trend on REM sleep in the first half of the night whereas at high doses, REM sleep reduction in the first part of sleep is significant. Total night REM sleep percentage is decreased in the majority of studies at moderate and high doses with no clear trend apparent at low doses. The onset of the first REM sleep period is significantly delayed at all doses and appears to be the most recognizable effect of alcohol on REM sleep followed by the reduction in total night REM sleep. The majority of studies, across dose, age and gender, confirm an increase in slow wave sleep (SWS) in the first half of the night relative to baseline values. The impact of alcohol on SWS in the first half of night appears to be more robust than the effect on REM sleep and does not appear to be an epiphenomenon REM sleep reduction. Total night SWS is increased at high alcohol doses across gender and age groups.
Surgical correction of buried penis: a review of 60 cases.

BACKGROUND/PURPOSE
The authors reviewed 60 cases of buried penis, treated in a single institution with postoperative follow-up for at least 6 months. The review was aimed at providing information that might help to optimize the results in future surgical correction of this uncommon, but not rare, congenital disorder.


METHODS
From January 1, 1989 to December 31, 1998, 62 boys with buried penis were treated with 1 of the following procedures: group 1A (n = 6), preputial unfurling alone; group 1B (n = 8), modified preputial unfurling; group 1C (n = 12), penoplasty devised by the first author with preservation of the preputial skin; and group 2 (n = 36), penoplasty with trimming of the inner preputial skin. Postoperative follow-up of more than 6 months after operation was achieved in 60 of 62 patients for a total of 25 patients in group 1 (A through C) and 35 patients in group 2.


RESULTS
Recurrent buried penis developed in 8 of 60 patients (13%), and redundant penile skin with or without lymphedema occurred in 18 (30%). The complications occurred in 18 of 25 patients (72%) in group 1 (A through C) but in only 8 of 35 (23%) in group 2. The difference was significant (P =.001). Most of the complications were mild and acceptable. A second procedure was required in 5 of the 25 patients in group 1 but in none of group 2. The second procedures were required to correct recurrent buried penis in 1 and to resect excess redundant penile skin in 4.


CONCLUSION
The superior results achieved in group 2 suggest that in addition to penoplasty with adequate fixation of the unfurling prepuce, resection of excess inner preputial skin is required to achieve an optimal outcome in children requiring surgical correction of buried penis.
Activity monitoring using an intelligent mobile phone: a validation study

This research examines both the practicalities and feasibility of using a smart phone in the monitoring of gross daily activity, namely step counts. An Adaptive Step Detection (ASD) algorithm has been proposed and evaluated, based on where the phone is worn on the body. Experiments involved collection of data from a participant who wore two mobile phones (placed at difference positions) while walking on a treadmill at a controlled speed for periods of five minutes. A video recording and pedometer were used to independently record the number of steps in addition to a count by human observation. A step detection calibration factor was determined via a data driven approach, i.e, for each recording, a calibration factor was obtained by learning from two thirds of the acceleration data gleaned from the accelerometer within the smart phone. The remainder of the data was used to test the algorithm. The step counts from the acceleration sensor were validated by the video recordings, which were consistent with the pedometer and human observation. The results show that the step counts detected by the proposed algorithm achieved accuracy of 100% when the mobile phone was placed in the right thigh positions, and achieved above 95% accuracy when the mobile phone was placed in the right breast pocket, bag over right shoulder and right ankle.
Anatomy and clinical significance of the maxillary nerve: a literature review.

BACKGROUND
The aim of this paper was to summarise the anatomical knowledge on the subject of the maxillary nerve and its branches, and to show the clinical usefulness of such information in producing anaesthesia in the region of the maxilla.


MATERIALS AND METHODS
A literature search was performed in Pubmed, Scopus, Web of Science and Google Scholar databases, including studies published up to June 2014, with no lower data limit.


RESULTS
The maxillary nerve (V2) is the middle sized branch of the trigeminal nerve - the largest of the cranial nerves. The V2 is a purely sensory nerve supplying the maxillary teeth and gingiva, the adjoining part of the cheek, hard and soft palate mucosa, pharynx, nose, dura mater, skin of temple, face, lower eyelid and conjunctiva, upper lip, labial glands, oral mucosa, mucosa of the maxillary sinus, as well as the mobile part of the nasal septum. The branches of the maxillary nerve can be divided into four groups depending on the place of origin i.e. in the cranium, in the sphenopalatine fossa, in the infraorbital canal, and on the face.


CONCLUSIONS
This review summarises the data on the anatomy and variations of the maxillary nerve and its branches. A thorough understanding of the anatomy will allow for careful planning and execution of anaesthesiological and surgical procedures involving the maxillary nerve and its branches.
Phase-I dose finding and pharmacokinetic study of the novel hydrophilic camptothecin ST-1968 (namitecan) in patients with solid tumors

Purpose: This is a first-in-human, phase I, dose-escalation study to determine the maximum tolerated dose (MTD) of intravenous, flat-dosed ST-1968 (namitecan), a new hydrophilic camptothecan derivative. Methods: Namitecan was administered intravenously over 2 h on day 1 and day 8 every 21 days (D1-D8-Q21D), starting at a flat dose of 2.5 mg, and increased according to a 3 + 3 cohort design. Due to frequent skipping of day 8 dosing for cytopenias, the study was expanded to test namitecan dosing on day 1 every 21 days (D1-Q21) at a starting dose of 17.5 mg. Major dose-limiting toxicity (DLT) was defined as grade (G) 4 neutropenia persisting >5 days, febrile neutropenia, G3 thrombocytopenia or G2 non-hematological toxicity. Results: Thirty-four patients were included into the D1-D8-Q21D group (2.5, 5, 10, 15, 17.5, 20 mg dosing cohorts), 29 patients into the D1-21D group (17.5, 20, 23, 27, 30 mg dosing cohorts). Neutropenia was the DLT in both groups, with 15 mg being defined as the recommended dose (RD) for the D1-D8-Q21D group, and 23 mg for the D1-Q21D group. Non-hematological toxicity was negligible. One patient with endometrial cancer in the D1-D8-Q21D group and one patient with cholangiocellular carcinoma in the D1-Q21D group experienced a partial remission. Namitecan exhibited fully dose-proportional pharmacokinetics. Conclusions: This study demonstrates clinical safety, favourable pharmacokinetics and preliminary antitumor activity of the novel hydrophilic camptothecin analogue namitecan in patients with heavily pretreated solid malignancies, when given either on a 2 out of 3 weeks or 3-weekly regimen.
On Data-Centric Misbehavior Detection in VANETs

Detecting misbehavior (such as transmissions of false information) in vehicular ad hoc networks (VANETs) is a very important problem with wide range of implications, including safety related and congestion avoidance applications. We discuss several limitations of existing misbehavior detection schemes (MDS) designed for VANETs. Most MDS are concerned with detection of malicious nodes. In most situations, vehicles would send wrong information because of selfish reasons of their owners, e.g. for gaining access to a particular lane. It is therefore more important to detect false information than to identify misbehaving nodes. We introduce the concept of data-centric misbehavior detection and propose algorithms which detect false alert messages and misbehaving nodes by observing their actions after sending out the alert messages. With the data-centric MDS, each node can decide whether an information received is correct or false. The decision is based on the consistency of recent messages and new alerts with reported and estimated vehicle positions. No voting or majority decisions is needed, making our MDS resilient to Sybil attacks. After misbehavior is detected, we do not revoke all the secret credentials of misbehaving nodes, as done in most schemes. Instead, we impose fines on misbehaving nodes (administered by the certification authority), discouraging them to act selfishly. This reduces the computation and communication costs involved in revoking all the secret credentials of misbehaving nodes.
Stock assessment in inland fisheries: a foundation for sustainable use and conservation

Fisheries stock assessments are essential for science-based fisheries management. Inland fisheries pose challenges, but also provide opportunities for biological assessments that differ from those encountered in large marine fisheries for which many of our assessment methods have been developed. These include the number and diversity of fisheries, high levels of ecological and environmental variation, and relative lack of institutional capacity for assessment. In addition, anthropogenic impacts on habitats, widespread presence of non-native species and the frequent use of enhancement and restoration measures such as stocking affect stock dynamics. This paper outlines various stock assessment and data collection approaches that can be adapted to a wide range of different inland fisheries and management challenges. Although this paper identifies challenges in assessment, it focuses on solutions that are practical, scalable and transferrable. A path forward is suggested in which biological assessment generates some of the critical information needed by fisheries managers to make effective decisions that benefit the resource and stakeholders.
Risk factors for mortality during antiretroviral therapy in older populations in resource-limited settings

INTRODUCTION
An increasing proportion of adult patients initiating antiretroviral therapy (ART) in resource-limited settings are aged > 50 years. Older populations on ART appear to have heightened risk of death, but little is known about factors influencing mortality in this population.


METHODS
We performed a retrospective observational multisite cohort study including all adult patients (≥ 15 years) initiating ART between 2003 and 2013 in programmes supported by Médecins Sans Frontières across 12 countries in Asia, Africa and Europe. Patients were stratified into two age groups, > 50 years and 15 to 50 years. A Cox proportional hazards model was used to explore factors associated with mortality.


RESULTS
The study included 41,088 patients: 2591 (6.3%) were aged > 50 years and 38,497 (93.7%) were aged 15 to 50 years. The mortality rate was significantly higher in the age group > 50 years [367 (14.2%) deaths; mortality rate 7.67 deaths per 100 person-years (95% confidence interval, CI: 6.93 to 8.50)] compared to the age group 15 to 50 years [3788 (9.8%) deaths; mortality rate 4.18 deaths per 100 person-years (95% CI: 4.05 to 4.31)], p < 0.0001. Higher CD4 levels at baseline were associated with significantly reduced mortality rates in the 15 to 50 age group but this association was not seen in the > 50 age group. WHO Stage 4 conditions were more strongly associated with increased mortality rates in the 15 to 50 age group compared to populations > 50 years. WHO Stage 3 conditions were associated with an increased mortality rate in the 15 to 50 age group but not in the > 50 age group. Programme region did not affect mortality rates in the > 50 age group; however being in an Asian programme was associated with a 36% reduced mortality rate in populations aged 15 to 50 years compared to being in an African programme. There was a higher overall incidence of Stage 3 WHO conditions in people > 50 years (12.8/100 person-years) compared to those 15 to 50 years (8.1/100 person-years) (p < 0.01). The rate of Stage 4 WHO conditions was similar (5.8/100 versus 6.1/100 respectively, p = 0.52). Mortality rates on ART associated with the majority of specific WHO conditions were similar between the 15 to 50 and > 50 age groups.


CONCLUSIONS
Older patients on ART in resource-limited settings have increased mortality rates, but compared to younger populations this appears to be less influenced by baseline CD4 count and WHO clinical stage. HIV treatment programmes in resource-limited settings need to consider risk factors associated with mortality on ART in older populations, which may differ to those related to younger adults.
Development of a validated clinical case definition of generalized tonic-clonic seizures for use by community-based health care providers.

PURPOSE
To develop and test a clinical case definition for identification of generalized tonic-clonic seizures (GTCSs) by community-based health care providers.


METHODS
To identify symptoms that can help identify GTCSs, patients with history of a jerky movements or rigidity in any part of the body ever in life were recruited from three sites: the community, secondary care hospital, and tertiary care hospital. These patients were administered a 14-item structured interview schedule focusing on the circumstances surrounding the seizure. Subsequently, a neurologist examined each patient and, based on available investigations, classified them as GTCS or non-GTCS cases. A logistic regression analysis was performed to select symptoms that were to be used for case definition of GTCSs. Validity parameters for the case definition at different cutoff points were calculated in another set of subjects.


RESULTS
In total, 339 patients were enrolled in the first phase of the study. The tertiary care hospital contributed the maximal number of GTCS cases, whereas cases of non-GTCS were mainly from the community. At the end of phase I, the questionnaire was shortened from 14 to eight questions based on statistical association and clinical judgment. After phase II, which was conducted among 170 subjects, three variables were found to be significantly related to the presence of GTCSs by logistic regression: absence of stress (13.1; 4.1-41.3), presence of frothing (13.7; 4.0-47.3), and occurrence in sleep (8.3; 2.0-34.9). As a case definition using only three variables did not provide sufficient specificity, three more variables were added based on univariate analysis of the data (incontinence during the episode and unconsciousness) and review of literature (injury during episode). A case definition consisting of giving one point to an affirmative answer for each of the six questions was tested. At a cutoff point of four, sensitivity was 56.9 (47.4-66.0) and specificity, 96.3 (86.2-99.4). Among the 197 GTCS and 26 new non-GTCS patients recruited from hospitals from select SEAR Member Countries, in phase III, the sensitivity of this clinical case definition was 72% and specificity, 100%. A stratified analysis by gender in all the three phases did not show any differences between the sexes.


CONCLUSIONS
Based on these criteria, we recommend that all patients with a history of two or more episodes of jerking or rigidity of limbs, having a score of > or =4 in the case definition, be identified as having GTCSs and started on antiepileptic medications. This clinical case definition can be very useful for community-based health care providers to identify and manage cases of GTCSs in the community. This should play a major role in the reduction of treatment gap for epilepsy in developing countries.
Pattern reconfigurable patch antenna with two orthogonal quasi-Yagi arrays

A pattern reconfigurable patch antenna suitable for wireless communication and satellite communication is described. Based on a quasi-Yagi microstrip patch antenna, the antenna reconfigures the pattern by using reconfigurable electromagnetic bang gap (EBG) structures. The circular polarization main lobe of the antenna covers the elevation range from 0/spl deg/ to 50/spl deg/ with a peak gain of 8.6 dBi around 9.9 GHz. Full azimuthal coverage can be obtained by changing the states of the EBG structures.
Performance pay in the public sector : A review of the issues and evidence

The work described in this report was carried out under contract as part of OME's research programme. The views and judgements expressed in this report are therefore those of the contractor and do not necessarily reflect those of OME. The purpose of this report is to assess recent, robust empirical studies of public sector incentive schemes and identify significant findings and common trends. As a backdrop we note some of the schemes in operation in the UK. Our assessment begins with the case for and against use of performance related pay, focusing on its use in the public sector and highlighting the fact that performance pay can have several effects, not all of which are beneficial. It then reviews the empirical literature for the following groups: civil servants (including police, armed forces and judiciary), healthcare workers and teachers. In choice of evidence, we have selected the most recent and the most robust evidence, which often comes from exploitation of actual or natural experiments. We have also tried to give some idea of the size of the evidence base for each set of workers, so assessment can be made of the 'weight' of the evidence. However, it should be noted that overall the size of the evidence base is not extensive and much of it is not from the UK so that often we are reliant on a small number of papers. Our first conclusion is that there is evidence that public sector workers do respond to financial schemes, particularly in the field of education and possibly also in health. Sometimes these responses are small, but often the incentive in the scheme is small too. Our second is that there is also evidence of gaming – manipulation of behaviour that uses resources and does not increase productivity-in response to schemes. Our final conclusion is that welfare calculations of the overall effect of performance related pay in the public sector are extremely rare, so that while it is possible to show that in some cases public sector workers have responded to these schemes, the overall benefits for society have not been assessed. In part, this is because such assessments are intrinsically hard to make; in other cases the schemes have not run for long enough t o observe more than their impact on the employees who have been the subject of the scheme.
On the Performance of Non-orthogonal Multiple Access Systems With Partial Channel Information

In this paper, a downlink single-cell non-orthogonal multiple access (NOMA) network with uniformly deployed users is considered and an analytical framework to evaluate its performance is developed. Particularly, the performance of NOMA is studied by assuming two types of partial channel state information (CSI). For the first one, which is based on imperfect CSI, we present a simple closed-form approximation for the outage probability and the average sum rate, as well as their high signal-to-noise ratio (SNR) expressions. For the second type of CSI, which is based on second order statistics (SOS), we derive a closed-form expression for the outage probability and an approximate expression for the average sum rate for the special case two users. For the addressed scenario with the two types of partial CSI, the results demonstrate that NOMA can achieve superior performance compared to the traditional orthogonal multiple access (OMA). Moreover, SOS-based NOMA always achieves better performance than that with imperfect CSI, while it can achieve similar performance to the NOMA with perfect CSI at the low SNR region. The provided numerical results confirm that the derived expressions for the outage probability and the average sum rate match well with the Monte Carlo simulations.
Mini-Sentinel and regulatory science--big data rendered fit and functional.

and informed-consent issues are being studied carefully by many parties, and solutions are in progress. However, global consensus on a minimum standard data set for EHRs, akin to the consensus-based minimum standard data set for global clinical research studies (Clinical Data Acquisition Standards Harmonization [CDASH]), could drive significant progress. A potential solution lies in a suite of CDISCinspired profiles from Integrating the Healthcare Enterprise that connect the Continuity of Care Document from EHRs with CDASH; since these standards lie at the intersection of health care and research, they could drive innovation by enabling EHRs to readily support standards-based research studies. The question is no longer whether but rather how clinical research data should be shared. EHR use is becoming routine, and responsible data sharing is being defined, with principles established and policies set globally. The precise format of the data to be shared cannot be an afterthought. In an era of increased transparency and integrative analyses of data from multiple origins, data standards are essential to ensure accuracy, reproducibility, and scientific integrity. Their use will help in fostering innovation — and thereby in honoring the sacrifices of research participants everywhere.