LLukas22/scidocs huggingface dataset:
Zinc supplementation has no effect on lipoprotein metabolism, hemostasis, and putative indices of copper status in healthy men

Pharmacological doses of zinc can adversely affect body copper status. The resulting copper deficiency can impact directly upon cholesterol metabolism and a suboptimal copper status has been observed to influence markers of hemostasis (specifically fibrinogen and the copper-containing coagulation factors V and VIII). The aim of this investigation was to examine the effect of a low level of zinc supplementation, to include dietary intake, at the United States tolerable upper intake level of 40 mg/d upon indicators of lipid metabolism, hemostasis, and copper. Thirty-eight subjects were recruited onto a double-blind placebo-controlled intervention trial and randomly selected to one of two groups. Group 1 took zinc supplements (30 mg/d) for 14 wk followed by copper supplements (3 mg/d) for 8 wk (to counteract adverse effects, if any, of zinc supplementation). A second group took placebo supplements for the full duration of the trial. Estimated dietary zinc intake approximated 10 mg/d. The effect of supplement was analyzed by repeated-measures analysis of variance (anova). Results indicate that no effect of zinc supplementation on putative indices of copper status, lipoprotein metabolism, and markers of hemostasis. These results indicate that short-term low-level zinc supplementation (total intake 40 mg/d) is not detrimental to health.
Indicators of fetal and infant health outcomes.

OBJECTIVE
To assess the ability of the member states of the European Union to produce the indicators recommended by the PERISTAT project on perinatal health indicators and to provide an overview of fetal and infant health outcomes for these countries according to the information now available.


METHODS
We used data from the PERISTAT survey of data providers to compute PERISTAT indicators of fetal and infant health.


RESULTS
National data on fetal mortality are available for all countries, but vary in their definitions. To adjust for these differences in definition, PERISTAT recommends presenting rates by gestational age and birth weight. Not all countries can provide neonatal mortality data by gestational age, birth weight or plurality, as recommended by PERISTAT. Few countries in Europe can report infant mortality rates by birth weight and gestational age. The other recommended indicators are available to varying degrees.


CONCLUSIONS
This overview, which shows that Europe can produce a variety of indicators for monitoring the health of its new-borns, indicates that some key dimensions of perinatal health cannot now be measured with routine health statistics and reveals important disparities in health outcomes throughout Europe. For most indicators, the highest values are between 50 and 100% higher than the lowest values. The reasons for these variations and their importance for the surveillance of perinatal health are discussed.
Comparison of the pharmacokinetic and pharmacodynamic profiles of insulin degludec and insulin glargine.

OBJECTIVES
A medical need remains for a once-daily insulin with 24-h basal coverage in all patients. We characterize the steady-state (SS) pharmacokinetic/pharmacodynamic properties of insulin degludec (IDeg) versus insulin glargine (IGlar).


RESEARCH DESIGN AND METHODS
In this controlled, single-center study, 66 type 1 diabetes patients were randomized to two 8-day periods of once-daily IDeg or IGlar at 0.4, 0.6 or 0.8 U/kg. At SS, subjects underwent a 42-h euglycemic glucose clamp (5.5 mmol/l; 100 mg/dl). Glucose infusion rate (GIR), distribution of GIR and half-life were assessed.


RESULTS
Mean 24-h GIR profiles were flatter and more stable for all doses of IDeg versus IGlar. The evenly distributed glucose-lowering effect of IDeg was confirmed by the AUCGIR across one dosing interval, as each of the four 6-h intervals across one dosing interval contributed ∼ 25% of the AUCGIR,τ,SS. IGlar was most effective during the first 12 - 18 h after dosing. At SS, the half-life was 25.4 (IDeg) versus 12.1 h (IGlar). No safety concerns were identified for IDeg or IGlar.


CONCLUSION
IDeg has a longer half-life (> 25 h) than IGlar. Exposure and glucose-lowering effects are more stable and evenly distributed across one dosing interval for IDeg versus IGlar (Clinical trials.gov identifier: NCT01114542).
Abstraction-Based Livelock/Deadlock Checking for Hardware Verification

ion-Based Livelock/Deadlock Checking for Hardware Verification In-Ho Moon and Kevin Harer Synopsys Inc. {mooni, kevinh}@synopsys.com
Symptomatic venous thromboembolism and mortality in orthopaedic surgery – an observational study of 45 968 consecutive procedures

BACKGROUND
Little information exists on the presentation of symptomatic venous thromboembolism (VTE) in orthopaedic surgery when a defined protocol for thromboprophylaxis is used. The objective with this study was to establish the VTE rate and mortality rate in orthopaedic surgery.


METHODS
We performed a prospective, single centre observational cohort study of 45 968 consecutive procedures in 36 388 patients over a 10 year period. Follow-up was successful in 99.3%. The primary study outcome was the incidence of symptomatic deep vein thrombosis (DVT), symptomatic pulmonary embolism (PE) and mortality at 6 weeks, specified for different surgical procedures. The secondary outcome was to describe the DVT distribution in proximal and distal veins and the proportion of VTEs diagnosed after hospital discharge. For validation purposes, a retrospective review of VTEs diagnosed 7-12 weeks postoperatively was also performed.


RESULTS
In total, 514 VTEs were diagnosed (1.1%; 95% CI: 1.10-1.14), the majority (84%) after hospital discharge (432 out of 514).With thromboprophylaxis, high incidence of VTE was found after internal fixation (IF) of pelvic fracture (12%; 95% CI: 5-26), knee replacement surgery (3.7%; 95% CI: 2.8-5.0), after internal fixation (IF) of proximal tibia fracture (3.8%; 95% CI: 2.3-6.3) and after IF of ankle fracture (3.6%; 95% CI: 2.9-4.4). Without thromboprophylaxis, high incidence of VTE was found after Achilles tendon repair (7.2%; 95% CI: 5.5-9.4). In total 1094 patients deceased (2.4%; 95% confidence interval (CI): 2.33- 2.44) within 6 weeks of surgery. Highest mortality was seen after lower limb amputation (16.3%, CI: 13.8-19.1) and after hip hemiarthroplasty due to hip fracture (9.6%, CI; 7.6-12.1).


CONCLUSION
The overall incidence of VTE is low after orthopaedic surgery but our study highlights surgical procedures after which the risk for VTE remains high and improved thromboprophylaxis is needed.
Comparative effectiveness studies to improve clinical outcomes in end stage renal disease: the DEcIDE patient outcomes in end stage renal disease study

BACKGROUND
Evidence is lacking to inform providers' and patients' decisions about many common treatment strategies for patients with end stage renal disease (ESRD).


METHODS/DESIGN
The DEcIDE Patient Outcomes in ESRD Study is funded by the United States (US) Agency for Health Care Research and Quality to study the comparative effectiveness of: 1) antihypertensive therapies, 2) early versus later initiation of dialysis, and 3) intravenous iron therapies on clinical outcomes in patients with ESRD. Ongoing studies utilize four existing, nationally representative cohorts of patients with ESRD, including (1) the Choices for Healthy Outcomes in Caring for ESRD study (1041 incident dialysis patients recruited from October 1995 to June 1999 with complete outcome ascertainment through 2009), (2) the Dialysis Clinic Inc (45,124 incident dialysis patients initiating and receiving their care from 2003-2010 with complete outcome ascertainment through 2010), (3) the United States Renal Data System (333,308 incident dialysis patients from 2006-2009 with complete outcome ascertainment through 2010), and (4) the Cleveland Clinic Foundation Chronic Kidney Disease Registry (53,399 patients with chronic kidney disease with outcome ascertainment from 2005 through 2009). We ascertain patient reported outcomes (i.e., health-related quality of life), morbidity, and mortality using clinical and administrative data, and data obtained from national death indices. We use advanced statistical methods (e.g., propensity scoring and marginal structural modeling) to account for potential biases of our study designs. All data are de-identified for analyses. The conduct of studies and dissemination of findings are guided by input from Stakeholders in the ESRD community.


DISCUSSION
The DEcIDE Patient Outcomes in ESRD Study will provide needed evidence regarding the effectiveness of common treatments employed for dialysis patients. Carefully planned dissemination strategies to the ESRD community will enhance studies' impact on clinical care and patients' outcomes.
Tool Wear Monitoring Tool Wear Monitoring Using Acoustic Emission

This research work highlights the effects of acoustic emission (AE) signals emitted during the milling of H13 tool steel as an important parameter in the identification of tool wear. These generated AE signals provide information on the chip formation, wear, fracture and general deformation. Furthermore, it is aimed at implementing an online monitoring system for machine tools, using a sensor fusion approach to adequately determine process parameters necessary for creating an adequate tool change timing schedule for machining operations. Keywords-Tool Wear Monitoring, acoustic emission, milling
International FItness Scale (IFIS): Construct Validity and Reliability in Women With Fibromyalgia: The al-Ándalus Project.

OBJECTIVES
To examine the construct validity of the International FItness Scale (IFIS) (ie, self-reported fitness) against objectively measured physical fitness in women with fibromyalgia and in healthy women; and to study the test-retest reliability of the IFIS in women with fibromyalgia.


DESIGN
Cross-sectional study.


SETTING
Fibromyalgia patient support groups.


PARTICIPANTS
Women with fibromyalgia (n=413) and healthy women (controls) (n=195) for validity purposes and women with fibromyalgia (n=101) for the reliability study. The total sample was N=709.


INTERVENTIONS
Not applicable.


MAIN OUTCOME MEASURES
Fitness level was both self-reported (IFIS) and measured using performance-based fitness tests. For the reliability study the IFIS was completed on 2 occasions, 1 week apart.


RESULTS
Women with fibromyalgia who reported average fitness had better measured fitness than those reporting very poor fitness (all P<.001, except 6-minute walk test where P<.05), with similar trends observed in healthy control women. The test-retest reliability of the IFIS, as measured by the average weighted κ, was .45.


CONCLUSIONS
The IFIS was able to identify women with fibromyalgia who had very low fitness and distinguish them from those with higher fitness levels. Furthermore, the IFIS was moderately reliable in women with fibromyalgia.
Comparison of high and low intensity contact between secondary and primary care to detect people at ultra-high risk for psychosis: study protocol for a theory-based, cluster randomized controlled trial

BACKGROUND
The early detection and referral to specialized services of young people at ultra-high risk (UHR) for psychosis may reduce the duration of untreated psychosis and, therefore, improve prognosis. General practitioners (GPs) are usually the healthcare professionals contacted first on the help-seeking pathway of these individuals.


METHODS/DESIGN
This is a cluster randomized controlled trial (cRCT) of primary care practices in Cambridgeshire and Peterborough, UK. Practices are randomly allocated into two groups in order to establish which is the most effective and cost-effective way to identify people at UHR for psychosis. One group will receive postal information about the local early intervention in psychosis service, including how to identify young people who may be in the early stages of a psychotic illness. The second group will receive the same information plus an additional, ongoing theory-based educational intervention with dedicated liaison practitioners to train clinical staff at each site. The primary outcome of this trial is count data over a 2-year period: the yield - number of UHR for psychosis referrals to a specialist early intervention in psychosis service - per primary care practice.


DISCUSSION
There is little guidance on the essential components of effective and cost-effective educational interventions in primary mental health care. Furthermore, no study has demonstrated an effect of a theory-based intervention to help GPs identify young people at UHR for psychosis. This study protocol is underpinned by a robust scientific rationale that intends to address these limitations.


TRIAL REGISTRATION
Current Controlled Trials ISRCTN70185866.
What Is Happiness? A Literature Review

As a counterpoint to our interview with Robert Lane, we asked this political scientist to take a further look at issues raised by Lane's work. He believes that happiness may well involve unselfishness. This is not necessarily the stuff on which the science of economics was originally built.
Supporting Self-Management in Dynamic Software Architecture Specifications ∗

Architectural change is defined as the addition and removal of components and connectors. Dynamic software architectures are those architectures that modify their architectural structure during the system’s execution. As dynamic software architecture use becomes more widespread, a variety of formal specification languages have been developed to gain a better understanding of the foundations of this type of software evolutionary change. In this paper we survey 14 formal specification approaches based on graphs, process algebras, logic, and other formalisms. Our survey will evaluate the ability of each approach to specify self-managing systems as well as the ability to address flexibility and scalability issues. Based on the results of our survey we will provide recommendations on future directions for improving the specification of dynamic software architectures, specifically self-managed architectures.
Role of the venous return in critical illness and shock: part II-shock and mechanical ventilation.

OBJECTIVE
To provide a conceptual and clinical review of the physiology of the venous system as it is related to cardiac function in health and disease.


DATA
An integration of venous and cardiac physiology under normal conditions, critical illness, and resuscitation.


SUMMARY
The usual clinical teaching of cardiac physiology focuses on left ventricular pathophysiology and pathology. Due to the wide array of shock states dealt with by intensivists, an integrated approach that takes into account the function of the venous system and its interaction with the right heart may be more useful. In part II of this two-part review, we describe the physiology of venous return and its interaction with the right heart function as it relates to mechanical ventilation and various shock states including hypovolemic, cardiogenic, obstructive, and septic shock. In particular, we demonstrate how these shock states perturb venous return/right heart interactions. We also show how compensatory mechanisms and therapeutic interventions can tend to return venous return and cardiac output to appropriate values.


CONCLUSION
An improved understanding of the role of the venous system in pathophysiologic conditions will allow intensivists to better appreciate the complex circulatory physiology of shock and related therapies. This should enable improved hemodynamic management of this disorder.
Developing priority criteria for hip and knee replacement: results from the Western Canada Waiting List Project.

INTRODUCTION
The Western Canada Waiting List Project (WCWL), a federally funded partnership of 19 organizations, was created to develop tools for managing waiting lists. The WCWL panel on hip and knee replacement surgery was 1 of 5 panels constituted under this project.


METHODS
The panel developed and tested a collection of standardized clinical criteria for setting priorities among patients awaiting hip and knee replacement. The criteria were applied to 405 patients in 4 provinces. Regression analysis was used to determine the set of criteria weights that collectively best predicted clinicians' overall urgency ratings. Inter-rater and test-retest reliability was assessed from 6 videotaped patient interviews, scored by orthopedic surgeons, related professionals and general practitioners.


RESULTS
The priority criteria accounted for over two-thirds of the observed variance in overall urgency ratings (adjusted R2 = 0.676). The panel modified the criteria and weights based on the empirical findings and on clinical judgement. The reliability of the priority criteria for the hip and knee replacement tool was among the strongest of the 5 instruments developed in the WCWL project.


CONCLUSIONS
The panel considered the criteria easy to use and reasonably reflective of expert surgical judgement regarding clinical urgency for hip and knee replacement. Further development and testing of the tool appears warranted.
Anti-inflammatory and analgesic activity of different fractions of Boswellia serrata.

The study was designed to investigate the anti-inflammatory and analgesic effect of different fractions of Boswellia serrata. The effect of different fractions of Boswellia serrata were studied using carrageenan induced paw edema, acetic acid induced writhing response, formalin induced pain, hot plate and tail flick method for studying anti-inflammatory and analgesic activity, respectively. The different fractions of B. serrata, essential oil (10 ml/kg), gum (100 mg/kg, resin (100 mg/kg) oleo-resin (100 mg/kg) and oleogum-resin (100 mg/kg) significantly reduces carrageenan induced inflammation in rats and shows analgesic activity, as determined by acetic acid induced writhing response, formalin induced pain, hot plate and tail flick method. The different fractions of B. serrata showed prompt antiinflammatory and analgesic activity due to the inhibition of 5-lipoxygenase enzyme.
Glaucoma in a rural population of southern India: the Aravind comprehensive eye survey.

PURPOSE
To determine the prevalence of glaucoma and risk factors for primary open-angle glaucoma in a rural population of southern India.


DESIGN
A population-based cross-sectional study.


PARTICIPANTS
A total of 5150 subjects aged 40 years and older from 50 clusters representative of three southern districts of Tamil Nadu in southern India.


METHODS
All participants had a comprehensive eye examination at the base hospital, including visual acuity using logarithm of the minimum angle of resolution illiterate E charts and refraction, slit-lamp biomicroscopy, gonioscopy, applanation tonometry, dilated fundus examinations, and automated central 24-2 full-threshold perimetry.


MAIN OUTCOME MEASURES
Definite primary open-angle glaucoma (POAG) was defined as angles open on gonioscopy and glaucomatous optic disc changes with matching visual field defects, whereas ocular hypertension was defined as intraocular pressure (IOP) greater than 21 mmHg without glaucomatous optic disc damage and visual field defects in the presence of an open angle. Manifest primary angle-closure glaucoma (PACG) was defined as glaucomatous optic disc damage or glaucomatous visual field defects with the anterior chamber angle partly or totally closed, appositional angle closure or synechiae in the angle, and absence of signs of secondary angle closure. Secondary glaucoma was defined as glaucomatous optic nerve damage and/or visual field abnormalities suggestive of glaucoma with ocular disorders that contribute to a secondary elevation in IOP.


RESULTS
The prevalence (95% confidence interval) of any glaucoma was 2.6% (2.2, 3.0), of POAG it was 1.7% (1.3, 2.1), and if PACG it was 0.5% (0.3, 0.7), and secondary glaucoma excluding pseudoexfoliation was 0.3% (0.2,0.5). On multivariate analysis, increasing age, male gender, myopia greater than 1 diopter, and pseudoexfoliation were significantly associated with POAG. After best correction, 18 persons (20.9%) with POAG were blind in either eye because of glaucoma, including 6 who were bilaterally blind and an additional 12 persons with unilateral blindness because of glaucomatous optic neuropathy in that eye. Of those identified with POAG, 93.0% had not been previously diagnosed with POAG.


CONCLUSIONS
The prevalence of glaucoma in this population is not lower than that reported for white populations elsewhere. A large proportion of those with POAG had not been previously diagnosed. One fifth of those with POAG had blindness in one or both eyes from glaucoma. Early detection of glaucoma in this population will reduce the burden of blindness in India.
Voltage Distribution Effects of Non-Uniform Units in Suspension Strings

10 unit and 22-unit cap-and-pin type insulator strings are used in 154 kV and 380 kV Turkish national power transmission systems. Turkish national electric power transmission utility staff prefer replacing the damaged units by stronger fog-type ones to minimize the transient outages resulting because of the insulation problems at the lower and upper units in the string. However, it is obvious that such a replacement changes the voltage distribution of the string composed of identical units. This change depends on the several parameters. This study presents the simulation results of voltage distribution along a 10-unit suspension string and 22-unit suspension string. Studies were conducted for the strings composed of different types of units for different tower designs and different contamination cases under power frequency voltages and lightning impulse voltages.
Scheduling of time critical processes

In real-time applications, the computer is often required to service programs in response to external signals, and to guarantee that each such program is completely processed within a specified interval following the occurrence of the initiating signal. Such programs are referred to in this paper as time-critical processes, or TCPs.
An Evolutionary Squeaky Wheel Optimization Approach to Personnel Scheduling

The quest for robust heuristics that are able to solve more than one problem is ongoing. In this paper, we present, discuss and analyze a technique called Evolutionary Squeaky Wheel Optimization and apply it to two different personnel scheduling problems. Evolutionary Squeaky Wheel Optimization improves the original squeaky wheel optimization's effectiveness and execution speed by incorporating two additional steps (selection and mutation) for added evolution. In the evolutionary squeaky wheel optimization, a cycle of analysis-selection-mutation-prioritization-construction continues until stopping conditions are reached. The aim of the analysis step is to identify below average solution components by calculating a fitness value for all components. The selection step then chooses amongst these underperformers and discards some probabilistically based on fitness. The mutation step further discards a few components at random. Solutions can become incomplete and thus repairs may be required. The repair is carried out by using the prioritization step to first produce priorities that determine an order by which the following construction step then schedules the remaining components. Therefore, improvements in the evolutionary squeaky wheel optimization is achieved by selective solution disruption mixed with iterative improvement and constructive repair. Strong experimental results are reported on two different domains of personnel scheduling: bus and rail driver scheduling and hospital nurse scheduling.