LLukas22/scidocs huggingface dataset:
Single-event multilevel surgery in children with spastic diplegia: a pilot randomized controlled trial.

BACKGROUND
Single-event multilevel surgery is considered the standard of care to improve gait and functioning of children with spastic diplegic cerebral palsy. However, the evidence base is limited. This pilot study is the first randomized controlled trial of single-event multilevel surgery, to our knowledge.


METHODS
Nineteen children (twelve boys and seven girls with a mean age of nine years and eight months) with spastic diplegia were enrolled. Eleven children were randomized to the surgical group and eight, to the control group. The control group underwent a program of progressive resistance strength training. The randomized phase of the trial concluded at twelve months. The control group then exited the study and progressed to surgery, whereas the surgical group continued to be followed in a prospective cohort study. The primary outcome measures were the Gait Profile Score (GPS) and the Gillette Gait Index (GGI). Secondary outcome measures were gross motor function (Gross Motor Function Measure-66 [GMFM-66]), functional mobility (Functional Mobility Scale [FMS]), time spent in the upright position, and health-related quality of life (Child Health Questionnaire [CHQ]).


RESULTS
A total of eighty-five surgical procedures were performed, with a mean of eight procedures per child (standard deviation, four). The surgical group had a 34% improvement in the GPS and a 57% improvement in the GGI at twelve months. The control group had a small nonsignificant deterioration in both indices. The between-group differences for the change in the GPS (-5.5; 95% confidence interval, -7.6 to -3.4) and the GGI (-218; 95% confidence interval, -299 to -136) were highly significant. The differences between the groups with regard to the secondary outcome measures were not significant at twelve months. At twenty-four months after surgery, there was a 4.9% increase in the GMFM-66 score and improvements in the FMS score, time spent in the upright position, and the physical functioning domain of the CHQ in the surgical group.


CONCLUSIONS
This study provides Level-II evidence that single-event multilevel surgery improves the gait of children with spastic diplegic cerebral palsy twelve months after surgery. Improvements in other domains, including gross motor function and quality of life, were not observed until twenty-four months after surgery.
The Effects of Social Media on E-Commerce: A Perspective of Social Impact Theory

In recent years social media has become more and more popular all around the world. This study aims to examine the influence of social media in the e-commerce context and to find how it impacts users' visit intention and purchase intention. Through a questionnaire survey, we test and analyze the research model and its related hypotheses by making use of structural equation modeling. The results indicate that social media interaction ties and social media commitment positively affect normative social influence and informational social influence. The last one in turn influences visit intention and purchase intention in e-commerce. In conclusion, we discuss the research findings and suggest some implications for researchers and practitioners.
Wheelchair navigation assisted by Human-Machine shared-control and a P300-based Brain Computer Interface

This paper presents a new shared-control approach for assistive mobile robots, using Brain Computer Interface (BCI) as the Human-Machine Interface (HMI). A P300-based paradigm that allows the selection of brain-actuated commands to steer a Robotic Wheelchair (RW), is proposed. At least one specific motor skill, such as the control of arms, legs, head or voice, is required to operate a conventional HMI. Due to this reason, they are not suited for people suffering from severe motor disorders. BCI may open a new communication channel to these users, since it does not require any muscular activity. The number of decoded symbols per minute (SPM) in a BCI is still very low, which means that users can only provide sparse, and discrete commands. The RW must rely on the navigation system to validate user commands effectively. A two-layer shared-control approach is proposed. The first, a virtual-constraint layer, is responsible for enabling/disabling the user commands, based on certain context restrictions. The second layer is an user-intent matching responsible for determining the suitable steering command, that better fits the user command, taking the user competence on steering the wheelchair into account. Experimental results using Robchair, the RW platform developed at ISR-UC [1], [2] are presented, showing the effectiveness of the proposed methodologies.
'To play or not to play': A cross-temporal investigation using hedonic and instrumental perspectives to explain user intentions to explore a technology

The present research extends prior work on the relationship between users and technology by examining users’ intention to explore a technology. Drawing on exploration and individual motivation theories, we developed and tested a model examining the effects of hedonic (i.e., personal innovativeness and cognitive absorption) and instrumental (i.e., performance expectancy and image enhancement) factors on individuals’ intentions to explore a technology over time. Based on a study of 94 users exposed to a new technology, with measurements taken at two points in time, we found that both instrumental and hedonic factors affect individuals’ intentions to explore, but their effects change over time such that as time goes by, the effect of personal innovativeness decreases and performance expectancy increases. In addition to our contributions and implications for research on technology acceptance, we present practical implications both for developers and managers, with a view toward helping the development and deployment of technologies that satisfy the evolution of users’ needs over time. & 2010 Published by Elsevier Ltd.
Flower development of Phalaenopsis orchid involves functionally divergent SEPALLATA-like genes

The Phalaenopsis orchid produces complex flowers that are commercially valuable, which has promoted the study of its flower development. E-class MADS-box genes, SEPALLATA (SEP), combined with B-, C- and D-class MADS-box genes, are involved in various aspects of plant development, such as floral meristem determination, organ identity, fruit maturation, seed formation and plant architecture. Four SEP-like genes were cloned from Phalaenopsis orchid, and the duplicated PeSEPs were grouped into PeSEP1/3 and PeSEP2/4. All PeSEPs were expressed in all floral organs. PeSEP2 expression was detectable in vegetative tissues. The study of protein-protein interactions suggested that PeSEPs may form higher order complexes with the B-, C-, D-class and AGAMOUS LIKE6-related MADS-box proteins to determine floral organ identity. The tepal became a leaf-like organ when PeSEP3 was silenced by virus-induced silencing, with alterations in epidermis identity and contents of anthocyanin and chlorophyll. Silencing of PeSEP2 had minor effects on the floral phenotype. Silencing of the E-class genes PeSEP2 and PeSEP3 resulted in the downregulation of B-class PeMADS2-6 genes, which indicates an association of PeSEP functions and B-class gene expression. These findings reveal the important roles of PeSEP in Phalaenopsis floral organ formation throughout the developmental process by the formation of various multiple protein complexes.
Death following intentional ingestion of e-liquid.

CONTEXT
Electronic cigarette (e-cigarette) use is growing within the United States, resulting in both intentional and unintentional exposures to concentrated liquid nicotine or "e-liquid." Nicotine has been culpable for severe poisoning and deaths in the past. However, sources of nicotine have traditionally been from cigarettes, cigars, or pesticides. Fatalities due to liquid nicotine are rare, and fatalities following ingestion of e-liquid are even scarcer.


CASE
We present a case of a 24-year-old woman who intentionally ingested up to 3000 mg of liquid nicotine intended for e-cigarette use. She was found in pulseless electrical activity and had return of spontaneous circulation (ROSC) after undergoing approximately 10 min of cardiopulmonary resuscitation with a blood pressure of 74/53 mmHg and a pulse rate of 106 beats/min. Despite aggressive supportive care, she ultimately died after she was found to have multiple acute infarcts, consistent with severe anoxic brain injury, on magnetic resonance imaging. The patient's toxicologic testing, obtained shortly after ROSC, was notable for plasma nicotine and cotinine levels each >1000 ng/mL.


DISCUSSION
This fatality highlights the potential toxicity associated with suicidal ingestion of liquid nicotine.
Paediatric out-of-hospital cardiac arrests: epidemiology and outcome.

INTRODUCTION
Little information is available regarding the outcome of children in our local population who sustained pre-hospital cardiac arrest. This study was performed to determine the survival rate among children after out-of-hospital cardiac arrest, to describe the epidemiology, and to identify predictors of survival.


METHODS
The records of 85 children who presented to a paediatric emergency department in cardiac arrest, between 1 June 1997 and 31 September 2001, were reviewed. The characteristics of the patients, cardiac arrest circumstances, and the outcomes of arrest were analysed.


RESULTS
85 children presented to the emergency department in cardiac arrest during the 52-month study period. 26 out of 85 children (30.6 percent) with cardiac arrest had return of spontaneous circulation (ROSC) after resuscitation efforts at the emergency department. Only four (4.7 percent) survived to be discharged from hospital and three of them survived beyond one year. Two of the cardiac arrest survivors had no change in the neurological status, with the remaining two sustaining severe neurological deficits. Emergency medical service was activated in only 63.7 percent of the patients. 34 percent of the arrests were witnessed, and only 22.9 percent of the children received bystander cardiopulmonary resuscitation (CPR). The positive predictors for survival to hospital discharge in a bivariate analysis were witnessed arrest (p-value is equal to 0.012), presence of bystander CPR (p-value is equal to 0.003), and duration of resuscitation (p-value is equal to 0.028). None who had more than 30 minutes of resuscitation in the emergency department survived. In a multivariate analysis with a logistic regression model, the only two independent predictors of ROSC were witnessed arrest (odds ratio is 3.049; 95% confidence interval [CI] is 1.101-8.444; p-value is equal to 0.032) and duration of resuscitation (odds ratio is 0.353; 95% CI is 0.146 - 0.854; p-value is equal to 0.021).


CONCLUSION
Out-of-hospital cardiac arrest in children has a poor prognosis and prolonged resuscitation at the emergency department beyond 30 minutes does not improve survival.
Phase II trial with letrozole to maximum response as primary systemic therapy in postmenopausal patients with ER/PgR[+] operable breast cancer.

PURPOSE
Letrozole is superior to tamoxifen in terms of response and breast preservation rates as primary systemic therapy (PST) in postmenopausal women with ER-positive early breast cancer. However, the optimum duration of endocrine PST remains uncertain.


METHODS
A phase 2 multicentre, open-label trial was conducted to evaluate the efficacy of letrozole over a preoperative period of 4 months to 1 year. Seventy postmenopausal patients (over 65 years) were recruited in four centers. The primary endpoint was to establish the optimal duration of treatment defined as the time required to attain the maximum response by clinical palpation.


RESULTS
The median age of the group was 79 years (66-91) and the median tumour size 35 mm (range 25-100 mm). No severe adverse events were reported. Fifty-six patients were evaluable for the primary objective. A total of 43 patients (76.8%) achieved an objective response; 29 (51.8%) being partial and 14 (25.0%) complete. The median time to objective response was 3.9 months (95% CI, 3.3-4.5) and the median time to maximum response was 4.2 months (95% CI, 4.0-4.5), although 20 (37.1%) patients achieved the maximal response within 6-12 months.


CONCLUSIONS
Letrozole shows a high activity and excellent tolerability as neoadjuvant therapy in elderly patients with endocrine-dependent breast cancer. Four to six months of letrozole as PST is an optimum duration with modest benefits thereafter.
Liveness and spoofing in fingerprint identification: issues and challenges

The fingerprint liveness detection refers to the inspection of the finger characteristics to ensure whether the input finger is live or artificial. A number of fingerprint identification systems are used widely and implemented at various important places such as border and immigration services. However, it is not declared by the manufacturers of these systems whether liveness detection is actually implemented. Possible measures to detect liveness are only proposed in patents and published literature. There are three major schemes, which are reported in fingerprint liveness literature. These coupled with the additional hardware, software, or combination of fingerprint with other identifications is aimed to verify the liveness in submitted fingerprints. The hardware-based methods use auxiliary sensors to detect the biological and physiological measurements from finger, whereas software-based methods utilize changes in physical properties that take place in early stages of pressing the finger. In this paper, various fingerprint liveness detection methods, which are categorized as voluntary and involuntary, are explored. These categories are based on determining the presence of a user by different responses from either voluntary (e.g. passwords or multiple biometrics) or involuntary (e.g. pulse oximetry or blood pressure) liveness detections. The main objective of this paper is to critically review the voluntary and involuntary fingerprint liveness detection techniques proposed in the literature, and discuss their effectiveness and possible limitations. Key-Words: Liveness Detection, Spoofing, Fingerprint, Biometric Security, Voluntary and Involuntary Technique
Tissue-engineered autologous grafts for facial bone reconstruction

Facial deformities require precise reconstruction of the appearance and function of the original tissue. The current standard of care—the use of bone harvested from another region in the body—has major limitations, including pain and comorbidities associated with surgery. We have engineered one of the most geometrically complex facial bones by using autologous stromal/stem cells, native bovine bone matrix, and a perfusion bioreactor for the growth and transport of living grafts, without bone morphogenetic proteins. The ramus-condyle unit, the most eminent load-bearing bone in the skull, was reconstructed using an image-guided personalized approach in skeletally mature Yucatán minipigs (human-scale preclinical model). We used clinically approved decellularized bovine trabecular bone as a scaffolding material and crafted it into an anatomically correct shape using image-guided micromilling to fit the defect. Autologous adipose-derived stromal/stem cells were seeded into the scaffold and cultured in perfusion for 3 weeks in a specialized bioreactor to form immature bone tissue. Six months after implantation, the engineered grafts maintained their anatomical structure, integrated with native tissues, and generated greater volume of new bone and greater vascular infiltration than either nonseeded anatomical scaffolds or untreated defects. This translational study demonstrates feasibility of facial bone reconstruction using autologous, anatomically shaped, living grafts formed in vitro, and presents a platform for personalized bone tissue engineering.
Design and analysis of a low-profile 28 GHz beam steering antenna solution for Future 5G cellular applications

A first-of-the-kind 28 GHz antenna solution for the upcoming 5G cellular communication is presented in detail. Extensive measurements and simulations ascertain the proposed 28 GHz antenna solution to be highly effective for cellular handsets operating in realistic propagating environments.
Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase

The ability to generate specific genetic modifications in mice provides a powerful approach to assess gene function. When genetic modifications have been generated in the germ line, however, the resulting phenotype often only reflects the first time a gene has an influence on - or is necessary for - a particular biological process. Therefore, systems allowing conditional genetic modification have been developed (for a review, see [1]); for example, inducible forms of the Cre recombinase from P1 phage have been generated that can catalyse intramolecular recombination between target recognition sequences (loxP sites) in response to ligand [2] [3] [4] [5]. Here, we assessed whether a tamoxifen-inducible form of Cre recombinase (Cre-ERTM) could be used to modify gene activity in the mouse embryo in utero. Using the enhancer of the Wnt1 gene to restrict the expression of Cre-ERTM to the embryonic neural tube, we found that a single injection of tamoxifen into pregnant mice induced Cre-mediated recombination within the embryonic central nervous system, thereby activating expression of a reporter gene. Induction was ligand dependent, rapid and efficient. The results demonstrate that tamoxifen-inducible recombination can be used to effectively modify gene function in the mouse embryo.
Successful Treatment with Peginterferon alfa-2b of HBeAg-positive HBV Non-Responders to Standard Interferon or Lamivudine

OBJECTIVES:Antiviral therapy leads to HBeAg seroconversion in 10–40% of the patients with HBeAg-positive chronic hepatitis B. Nonresponse may result in progression of liver disease and increased risk of hepatocellular carcinoma. As part of a global randomized controlled trial we investigated the efficacy (i.e., loss of HBeAg at the end of follow-up) of peginterferon alfa-2b (Peg-IFN α2b) in patients who failed to respond to previous courses of standard interferon (IFN) or lamivudine.METHODS:We analyzed a total of 76 previous nonresponders: 37 were nonresponders to standard IFN, 17 were nonresponders to lamivudine, and 22 were nonresponders to both therapies. All patients received a 52-wks course of 100 μg Peg-IFN α2b weekly combined with either 100 mg lamivudine daily or a placebo. After therapy patients were followed for 26 wks.RESULTS:Thirteen (35%) nonresponders to previous IFN, five (29%) nonresponders to previous lamivudine, and four (22%) nonresponders to both IFN and lamivudine responded to treatment with Peg-IFN α2b. No difference in response was found for those treated with Peg-IFN α2b alone or in combination with lamivudine. Nonresponders to prior IFN therapy with baseline ALT (alanine aminotransferase) > 4 × ULN (upper limit of normal) responded better to Peg-IFN α2b than those with ALT levels ≤ 4 × ULN (53% vs 20%, respectively, p = 0.036).CONCLUSIONS:Peg-IFN α2b is effective in approximately one-third of patients who failed to respond to previous treatment with standard IFN or lamivudine. High serum ALT level at baseline of Peg-IFN α2b therapy was the best predictor for response in these patients.
Double-orientation code and nonlinear matching scheme for palmprint recognition

Many palmprint authentication approaches have been proposed in recent years. Among them, the orientation based coding approach, in which the dominant orientation features of palmprints are extracted and encoded into bitwise codes, is one of the most promising approaches. The distance between codes created from two palmprint images is calculated in the matching stage. Reliable orientation feature extraction and efficient matching are the two most crucial problems in orientation based coding approaches. However, conventional coding based approaches usually extract only one dominant orientation feature by adopting filters with discrete orientations, which is sensitive to the noise and rotation. This paper proposed a novel double-orientation code (DOC) scheme to represent the orientation feature of palmprint and designed an effective nonlinear angular matching score to evaluate the similarity between the DOC. Extensive experiments performed on three types of palmprint databases demonstrate that the proposed approach has excellent performance in comparison with previously proposed state-of-the-art approaches. & 2015 Elsevier Ltd. All rights reserved.
Clinical effectiveness of a manual based coping strategy programme (START, STrAtegies for RelaTives) in promoting the mental health of carers of family members with dementia: pragmatic randomised controlled trial

OBJECTIVE
To assess whether a manual based coping strategy compared with treatment as usual reduces depression and anxiety symptoms in carers of family members with dementia.


DESIGN
Randomised, parallel group, superiority trial.


SETTING
Three mental health community services and one neurological outpatient dementia service in London and Essex, UK.


PARTICIPANTS
260 carers of family members with dementia.


INTERVENTION
A manual based coping intervention comprising eight sessions and delivered by supervised psychology graduates to carers of family members with dementia. The programme consisted of psychoeducation about dementia, carers' stress, and where to get emotional support; understanding behaviours of the family member being cared for, and behavioural management techniques; changing unhelpful thoughts; promoting acceptance; assertive communication; relaxation; planning for the future; increasing pleasant activities; and maintaining skills learnt. Carers practised these techniques at home, using the manual and relaxation CDs.


MAIN OUTCOME MEASURES
Affective symptoms (hospital anxiety and depression total score) at four and eight months. Secondary outcomes were depression and anxiety caseness on the hospital anxiety and depression scale; quality of life of both the carer (health status questionnaire, mental health) and the recipient of care (quality of life-Alzheimer's disease); and potentially abusive behaviour by the carer towards the recipient of care (modified conflict tactics scale).


RESULTS
260 carers were recruited; 173 were randomised to the intervention and 87 to treatment as usual. Mean total scores on the hospital anxiety and depression scale were lower in the intervention group than in the treatment as usual group over the eight month evaluation period: adjusted difference in means -1.80 points (95% confidence interval -3.29 to -0.31; P=0.02) and absolute difference in means -2.0 points. Carers in the intervention group were less likely to have case level depression (odds ratio 0.24, 95% confidence interval 0.07 to 0.76) and there was a non-significant trend towards reduced case level anxiety (0.30, 0.08 to 1.05). Carers' quality of life was higher in the intervention group (difference in means 4.09, 95% confidence interval 0.34 to 7.83) but not for the recipient of care (difference in means 0.59, -0.72 to 1.89). Carers in the intervention group reported less abusive behaviour towards the recipient of care compared with those in the treatment as usual group (odds ratio 0.47, 95% confidence interval 0.18 to 1.23), although this was not significant.


CONCLUSIONS
A manual based coping strategy was effective in reducing affective symptoms and case level depression in carers of family members with dementia. The carers' quality of life also improved.


TRIAL REGISTRATION
Current Controlled Trials ISCTRN70017938.
Abstract Semantic Differencing for Numerical Programs

Semantic Differencing for Numerical Programs Nimrod Partush Eran Yahav
Sources for Software Development: A Mugwumpish View

Outsourcing, overseas development, and foreign workers displacing American ones: These are all interesting issues, but in a sense they're all so "last century." Or are they?