LLukas22/scidocs huggingface dataset:
Symptoms of Depression Are Associated With Opioid Use Regardless of Pain Severity and Physical Functioning Among Treatment-Seeking Patients With Chronic Pain.

Depression may be a critical factor in the initiation and maintenance of opioids. This study investigated the association among opioid use, pain, and depression in patients evaluated at a university-based outpatient pain clinic. Of the 2,104 new patients included, 55.89% reported current opioid use and showed a worse phenotypic profile (eg, higher pain severity, worse physical functioning) compared with nonopioid users. In addition, more opioid users reported symptoms suggestive of depression than those not taking opioids (43.6% vs 26.8%, P < .001). In a multivariate logistic regression model, increased pain severity was associated with increased probability of taking opioids; however, this was moderated by depression (estimate = -.212, P < .001). For nondepressed patients, the predicted probabilities of opioid use increased as pain severity increased. In contrast, among patients with symptoms of depression, the probability of taking opioids did not change based on pain severity. Similarly, although increased physical function was associated with increased probability of opioid use, this was moderated by depression (estimate = .033, P = .034). Patients with symptoms of depression were more likely to be taking opioids at higher levels of functioning (Ps < .03). Perspective: This study investigated the association among opioid use, pain, and depression at a university-based outpatient pain clinic. Depression emerged as a moderator of the relationship among opioid use, pain severity, and physical functioning. These findings lend support to the hypothesis that patients may be self-medicating affective pain with opioids.
Dynamics of the HIV-1 latent reservoir after discontinuation of the intensification of antiretroviral treatment: results of two clinical trials.

OBJECTIVE
Antiretroviral therapy (ART) intensification has been shown to reduce the reservoir of latently infected CD4 T cells. However, it is currently unknown whether this effect is maintained after discontinuation of the intensifying drug.


DESIGN
The effect of ART intensification during 48 weeks with maraviroc or raltegravir in chronically HIV-1-infected patients was assessed in two previous clinical trials. In this study, we analysed this effect at week 24 after discontinuation of the intensifying drugs, at baseline and 48 weeks of intensification.


METHODS
We measured the latently infected memory CD4 T cells carrying replication-competent virus, 2-long terminal repeat (2-LTR) circles and CD4/CD8 T cells activation.


RESULTS
Fifteen patients were evaluated. After 48 weeks of intensification, HIV-1 reservoir size significantly decreased from 1.1 to 0.0 infectious units per million (IUPM) (P=0.004). After 24 weeks of drug discontinuation, the median size of the reservoir was still significantly lower than at baseline (P=0.008). 2-LTRs were undetectable in all individuals at baseline and after 48 weeks of intensification, continuing undetectable in all patients except two at week 24 after discontinuation (P=0.1). CD4 and CD8 T-cell activation significantly decreased at 48 weeks after intensification, without further increase after discontinuation.


CONCLUSION
The effects of ART intensification with maraviroc or raltegravir persist at least 24 weeks after discontinuation of the drug. In a global strategy, ART intensification should be considered as part of a combination approach to achieve a functional cure or HIV eradication.
Wall shear stress at the initiation site of cerebral aneurysms.

Hemodynamics are believed to play an important role in the initiation of cerebral aneurysms. In particular, studies have focused on wall shear stress (WSS), which is a key regulator of vascular biology and pathology. In line with the observation that aneurysms predominantly occur at regions of high WSS, such as bifurcation apices or outer walls of vascular bends, correlations have been found between the aneurysm initiation site and high WSS. The aim of our study was to analyze the WSS field at an aneurysm initiation site that was neither a bifurcation apex nor the outer wall of a vascular bend. Ten cases with aneurysms on the A1 segment of the anterior cerebral artery were analyzed and compared with ten controls. Aneurysms were virtually removed from the vascular models of the cases to mimic the pre-aneurysm geometry. Computational fluid dynamics (CFD) simulations were created to assess the magnitude, gradient, multidirectionality, and pulsatility of the WSS. To aid the inter-subject comparison of hemodynamic variables, we mapped the branch surfaces onto a two-dimensional parametric space. This approach made it possible to view the whole branch at once for qualitative evaluation. It also allowed us to empirically define a patch for quantitative analysis, which was consistent among subjects and encapsulated the aneurysm initiation sites in our dataset. To test the sensitivity of our results, CFD simulations were repeated with a second independent observer virtually removing the aneurysms and with a 20 % higher flow rate at the inlet. We found that branches harboring aneurysms were characterized by high WSS and high WSS gradients. Among all assessed variables, the aneurysm initiation site most consistently coincided with peaks of temporal variation in the WSS magnitude.
How Social Ties Influence Consumer: Evidence from Event-Related Potentials

A considerable amount of marketing research has reported that consumers are more saliently influenced by friends (strong social ties) than by acquaintances and strangers (weak social ties). To shed light on the neural and psychological processes underlying such phenomenon, in this study we designed an amended S1-S2 paradigm (product-[reviewer-review]) that is based on realistic consumer purchase experiences. After incoming all given information (product, reviewer, review), participants were required to state their purchase intentions. The neurocognitive and emotional processes related to friend and stranger stimuli were delineated to suggest how social ties influence consumers during their shopping processes. Larger P2 (fronto-central scalp areas) and P3 (central and posterior-parietal scalp areas) components under stranger condition were elicited successfully. These findings demonstrate that the cognitive and emotional processing of friend and stranger stimuli occurs at stages of neural activity, and can be indicated by the P2 and P3 components. Electrophysiological data also support the hypothesis that different neural and emotional processing magnitude and strength underlie friend and stranger effect in the context of consumer purchase. During this process, the perception of stimuli evoked P2, subsequently emotional processing and attention modulation were activated and indicated by P2 and P3. The friend dominated phenomenon can be interpreted as the result of distinctive neurocognitive and emotional processing magnitude, which suggests that psychological and emotional factors can guide consumer decision making. This study consolidates that event related potential (ERP) methodology is likely to be a more sensitive method for investigating consumer behaviors. From the perspectives of management and marketing, our findings show that the P2 and P3 components can be employed as an indicator to probe the influential factors of consumer purchase intentions.
The Spreadsheet Space: Eliminating the Boundaries of Data Cross-Referencing

In the Spreadsheet Space, a virtual space for tabular data sharing, users in diverse administrative domains reference each others' spreadsheets at the cell level as well as share data from a variety of platforms and databases. Spreadsheet Space users enjoy the unlimited scope of cloud collaboration with the security of a more limited environment.
Crosstalk between two microstrip lines excited by a gap voltage source

The crosstalk between two microstrip lines is studied when one of the lines (the source line) is excited by a gap voltage source. In particular, the current induced on the passive line (the victim line) due to electromagnetic coupling to the source line is studied as a function of line separation and frequency for different permittivities. Results are also presented for the case of the source line excited by a vertical electric dipole to explore the effect of different source excitations on the crosstalk current. The current is calculated using a semianalytical method, which allows for an examination of the constituent current components on the lines (the bound-mode and continuous-spectrum currents) so that the physical mechanisms of coupling can be explored. The calculation is performed in an efficient manner using a mixed-potential integral-equation formulation with complex images.
Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012.

INTRODUCTION
Cancer incidence and mortality estimates for 25 cancers are presented for the 40 countries in the four United Nations-defined areas of Europe and for the European Union (EU-27) for 2012.


METHODS
We used statistical models to estimate national incidence and mortality rates in 2012 from recently-published data, predicting incidence and mortality rates for the year 2012 from recent trends, wherever possible. The estimated rates in 2012 were applied to the corresponding population estimates to obtain the estimated numbers of new cancer cases and deaths in Europe in 2012.


RESULTS
There were an estimated 3.45 million new cases of cancer (excluding non-melanoma skin cancer) and 1.75 million deaths from cancer in Europe in 2012. The most common cancer sites were cancers of the female breast (464,000 cases), followed by colorectal (447,000), prostate (417,000) and lung (410,000). These four cancers represent half of the overall burden of cancer in Europe. The most common causes of death from cancer were cancers of the lung (353,000 deaths), colorectal (215,000), breast (131,000) and stomach (107,000). In the European Union, the estimated numbers of new cases of cancer were approximately 1.4 million in males and 1.2 million in females, and around 707,000 men and 555,000 women died from cancer in the same year.


CONCLUSION
These up-to-date estimates of the cancer burden in Europe alongside the description of the varying distribution of common cancers at both the regional and country level provide a basis for establishing priorities to cancer control actions in Europe. The important role of cancer registries in disease surveillance and in planning and evaluating national cancer plans is becoming increasingly recognised, but needs to be further advocated. The estimates and software tools for further analysis (EUCAN 2012) are available online as part of the European Cancer Observatory (ECO) (http://eco.iarc.fr).
Analysis and implementation of distributed algorithms for multi-robot systems

Distributed algorithms for multi-robot systems rely on network communications to share information. However, the motion of the robots changes the network topology, which affects the information presented to the algorithm. For an algorithm to produce accurate output, robots need to communicate rapidly enough to keep the network topology correlated to their physical configuration. Infrequent communications will cause most multirobot distributed algorithms to produce less accurate results, and cause some algorithms to stop working altogether. The central theme of this work is that algorithm accuracy, communications bandwidth, and physical robot speed are related. This thesis has three main contributions: First, I develop a prototypical multi-robot application and computational model, propose a set of complexity metrics to evaluate distributed algorithm performance on multi-robot systems, and introduce the idea of the robot speed ratio, a dimensionless measure of robot speed relative to message speed in networks that rely on multi-hop communication. The robot speed ratio captures key relationships between communications bandwidth, mobility, and algorithm accuracy, and can be used at design time to trade off between them. I use this speed ratio to evaluate the performance of existing distributed algorithms for multi-hop communication and navigation. Second, I present a definition of boundaries in multi-robot systems, and develop new distributed algorithms to detect and characterize them. Finally, I define the problem of dynamic task assignment, and present four distributed algorithms that solve this problem, each representing a different trade-off between accuracy, running time, and communication resources. All the algorithms presented in this work are provably correct under ideal conditions and produce verifiable real-world performance. They are self-stabilizing and robust to communications failures, population changes, and other errors. All the algorithms were tested on a swarm of 112 robots. Thesis Supervisor: Leslie P. Kaelbling Title: Professor
Intravitreal triamcinolone acetonide as treatment of macular edema in central retinal vein occlusion

Purpose. To report the clinical outcome of a patient receiving an intravitreal injection of triamcinolone acetonide as treatment of bilateral, long-standing, cystoid macular edema due to central retinal vein occlusion. Methods. A 70-years-old patient suffering from bilateral central retinal vein occlusion for 2 years and 1.5 years, respectively, received transconjunctivally an intravitreal injection of 25 mg of crystalline triamcinolone acetonide in each eye, with 10 weeks between injections. Results. During the follow-up period of 4 months (OD) and 6 weeks (OS), respectively, visual acuity increased from 0.05 to 0.25 in his right eye and from 0.125 to 0.25 in his left eye. Fluorescein angiography showed a decrease of fluorescein leakage in the macular area. Conclusions. Intravitreal injection of triamcinolone acetonide may be a therapeutic option for long-standing cystoid macular edema due to central retinal vein occlusion.
Knowledge Sharing, Job Attitudes and Organisational Citizenship Behaviour

Purpose – There are very few studies on the impact of job attitude on knowledge sharing. The purpose of this paper is to examine the effects of job involvement, job satisfaction, organisational commitment, and organisational citizenship behaviour (OCB) on employees’ knowledge sharing behaviour. Design/methodology/approach – This research is based on a survey of 116 Information Systems personnel in Malaysia. Structural equation modelling is used to test the hypothesis. Findings – The results show that job involvement, job satisfaction and OCB are independent and positively related to employees’ knowledge sharing behaviour. However, organisational commitment has a negative relationship with knowledge sharing behaviour. It is found that OCB is not a significant mediator between job involvement, job satisfaction organisational commitment and knowledge sharing behaviour. Research limitations/implications – It is widely reported that knowledge workers may not be willing to share with others since they can always argue that it is not their job to share. Therefore, knowledge sharing can be regarded as an extra job. OCB is an extra-role behaviour which is especially relevant to research on knowledge sharing. Theories and research methods in OCB may be used in future research on knowledge sharing. Practical implications – Given the importance of knowledge sharing in today’s competitive business world, this study provides a broader understanding of different dimensions of job attitudes in relation to employees’ knowledge sharing behaviours. Our findings suggest that organisational administrators and managers should look into ways of improving the levels of job satisfaction, job involvement, and OCB in order to facilitate knowledge sharing behaviour. Originality/value – This study makes two distinct additions to the organisational behaviour and knowledge sharing literature. First, job attitudes appear to be significantly related to knowledge sharing behaviour, addressing a research gap in the literature of knowledge sharing and employee attitudes. Second, this study reveals that OCB directly affects knowledge sharing but it does not mediate employees’ job attitudes to promote knowledge sharing behaviours.
GRAM: Graph-based Attention Model for Healthcare Representation Learning

Deep learning methods exhibit promising performance for predictive modeling in healthcare, but two important challenges remain: - Data insufficiency: Often in healthcare predictive modeling, the sample size is insufficient for deep learning methods to achieve satisfactory results. - Interpretation: The representations learned by deep learning methods should align with medical knowledge.
 To address these challenges, we propose GRaph-based Attention Model (GRAM) that supplements electronic health records (EHR) with hierarchical information inherent to medical ontologies. Based on the data volume and the ontology structure, GRAM represents a medical concept as a combination of its ancestors in the ontology via an attention mechanism.
 We compared predictive performance (i.e. accuracy, data needs, interpretability) of GRAM to various methods including the recurrent neural network (RNN) in two sequential diagnoses prediction tasks and one heart failure prediction task. Compared to the basic RNN, GRAM achieved 10% higher accuracy for predicting diseases rarely observed in the training data and 3% improved area under the ROC curve for predicting heart failure using an order of magnitude less training data. Additionally, unlike other methods, the medical concept representations learned by GRAM are well aligned with the medical ontology. Finally, GRAM exhibits intuitive attention behaviors by adaptively generalizing to higher level concepts when facing data insufficiency at the lower level concepts.
On the risk of upward lightning initiated from wind turbines

In recent years the number of wind turbines installed in Europe and other continents has increase dramatically. Appropriate lightning protection is required in order to avoid costly replacements of lightning damaged turbine blades, components of the electronic control system, and/or temporary loss of energy production. Depending on local site conditions elevated objects with heights of 100 m and more can frequently initiate upward lightning. From the 100 m high and instrumented radio tower on Gaisberg in Austria more than 50 flashes per year are initiated and measured. Also lightning location systems or video studies in Japan [1], [2] or in the US [3] show frequent occurrence of lightning initiated from wind turbines, especially during cold season. Up to now no reliable method exists to estimate the expected frequency of upward lightning for a given structure and location. About half of the flashes observed at the GBT are of ICCOnly type. Unfortunately this type of discharge is not detected by lightning location systems as its current waveform does not show any fast rising and high peak current pulses as typical for first or subsequent return strokes in downward lightning (cloud-to-ground). Nevertheless some of this ICCOnly type discharges transferred the highest amount of charge, exceeding the 300 C specified in IEC 62305 for lightning protection level LPL I.
SOCIAL IDENTITY IN INDUSTRIAL AND ORGANIZATIONAL PSYCHOLOGY: CONCEPTS, CONTROVERSIES AND CONTRIBUTIONS

It is now 25 years since the publication of Tajfel and Turner’s (1979) seminal statement on social identity theory and 15 years since Ashforth and Mael (1989) published their classic Academy of Management Review article pointing to the potential value of using this theory to enhance researchers’ understanding of organizational life. Whatever else the latter article may have achieved, it is clear that it was highly prophetic, as, over the intervening period, industrial and organizational psychologists’ interest in social identity and related concepts has increased at a phenomenal rate. On top of nearly 300 citations of the Ashforth and Mael paper, this is indicated, among other developments, by the publication of several key books and journal special issues devoted to research in this area (e.g., Albert, Ashforth, & Dutton, 2000; Haslam, 2001, 2004; Haslam, van Knippenberg, Platow, & Ellemers, 2003; Hogg & Terry, 2001; Tyler & Blader, 2000; van Knippenberg & Hogg, 2001) and the exponential rise in articles that make reference to the terms ‘social’ and/or ‘organizational’ identity (for details see Haslam, 2004, p. xxv; Haslam, Postmes, & Ellemers, 2003). As the range of journals listed in Table 2.1 indicates, it is also apparent that this research has had a broad as well as a deep impact on the field. These trends indicate that a thoroughgoing review of the status of social identity in industrial and organizational fields is very timely (see also
Age-related changes in sleep/wake patterns among Korean teenagers.

INTRODUCTION
As children go through the transition from childhood to adolescence, many shifts occur in sleep/wake patterns related to intrinsic and extrinsic developmental changes. These shifts have been shown to result in corresponding shifts in sleep phase (later sleep onset) and sleep deprivation among teenagers in Western societies. However, the effect of these developmental changes on the sleep habits of Korean teenagers has not been analyzed. This study aims to quantify age-related changes in sleep/wake patterns among Korean teenagers and elucidate cultural and other factors causing these changes.


METHODS
The School Sleep Habits Survey was administered in homeroom classes to students in grades 5 to 12 (mean age: 13.7 +/- 2.4 years) selected via a 2-way stratification sampling method. The survey included items regarding usual sleep/wake patterns over the previous 2 weeks as well as measures of daytime sleepiness, sleep/wake-problem behavior, depressed mood, and morningness/eveningness.


RESULTS
A total of 1457 students (52.9% male) completed the survey. The higher the grade, the later bedtime was found to be on both school days and weekends. There was a similar relationship between increasing grade and earlier wake time on school days, but higher grades were associated with later wake time on weekends. Total sleep time decreased by approximately 3 hours on school nights and 1 hour on weekend nights from grades 5 to 12. Adolescents were severely sleep deprived, with mean school-night total sleep times of 6.02, 5.62, and 4.86 hours for 10th-, 11th-, and 12th-graders, respectively. In the higher grades, there was a greater discrepancy between school nights and weekends in terms of bedtime and wake time, and the magnitude of weekend oversleep increased. Older students also reported more daytime sleepiness, more sleep/wake-problem behavior, more depressed mood, and more eveningness preference. The chief reasons students cited for their sleep deprivation differed across grades: Academic demands and entertainment (such as Internet and television) were reported by 5th- and 6th-graders, entertainment and then academic demands by 7th-, 8th-, and 9th-graders, and early school start time and academic demands by 10th-, 11th- and 12th-graders.


CONCLUSIONS
This study clearly demonstrates that Korean adolescents do not get adequate sleep and that they have profound discrepancies in their sleep/wake patterns between school and weekend nights. Compared with previous studies from other countries, Korean students display even greater sleep deprivation and also more irregular sleep/wake patterns. This study also demonstrates that academic demands/stress and early school start time are the most important contributing factors for sleep deprivation among Korean adolescents. These findings stress the need to promote awareness of the magnitude of adolescent sleep deprivation and its detrimental effects in Korean society.