LLukas22/scidocs huggingface dataset:
Rhinoplasty for the Asian nose.

When compared with Caucasian noses, the typical Asian nose appears to be relatively small and flat and has poor tip definition. Therefore, the main concept of rhinoplasty for Asians is augmentation rather than reduction. In selecting the dorsal implant material, skin thickness should be considered. Although autologous cartilage has the lowest risk of infection among graft materials, autologous cartilage including costal cartilage is associated with a significant risk of revision surgery due to aesthetic failure. Alloplastic implants, including silicone and Gore-Tex, are easy to use and can reduce operation time. But they carry significant risks of complications including infection, deviation, extrusion, and delayed inflammation, which must be seriously considered by rhinoplasty surgeons. Cartilage grafting procedures, including shield graft, onlay graft, modified vertical dome division, and septal extension graft, are mainstays in proper projection and better refinement of the Asian tip, which is intrinsically round and underdeveloped in its appearance. In placing a shield graft, it is important to place an additional supporting graft at the cephalic border and additional tip grafts at the caudal aspect, so that the final tip graft complex has an antero-caudal projection on the profile view.
Role of the estrogen and progestin in hormonal replacement therapy on apolipoprotein A-I kinetics in postmenopausal women.

OBJECTIVE
Plasma high-density lipoprotein (HDL) cholesterol levels are inversely correlated with the risk of developing coronary heart disease. Hormonal replacement therapy (HRT) affects plasma HDL cholesterol levels, with estrogen increasing HDL cholesterol levels and progestins blunting this effect. This study was designed to assess the mechanism responsible for these effects.


MATERIALS AND METHODS
HDL apolipoprotein A-I (apoA-I) kinetics were studied in 8 healthy postmenopausal women participating in a double-blind, randomized, crossover study comprising 3 phases: placebo, conjugated equine estrogen (CEE) (0.625 mg/d), and CEE plus medroxyprogesterone acetate (MPA) (2.5 mg/d). Compared with placebo, treatment with CEE resulted in an increase in apoA-I pool size (+20%, P<0.01) because of a significant increase in apoA-I production rate (+47%, P<0.05) and no significant changes in apoA-I fractional catabolic rate. Compared with the CEE alone phase, treatment with the CEE plus MPA resulted in an 8% (P<0.02) reduction in apoA-I pool size and a significant reduction in apoA-I production rate (-13%, P<0.04), without changes in apoA-I fractional catabolic rate.


CONCLUSIONS
Postmenopausal estrogen replacement increases apoA-I levels and production rate. When progestin is added to estrogen, it opposes these effects by reducing the production of apoA-I.
Effect of interpregnancy interval on adverse perinatal outcomes--a national study.

BACKGROUND
The interpregnancy interval (IPI) has been reported to influence the outcome of pregnancy and birth. We performed a national study in Israel to determine the impact of IPI on multiple adverse perinatal outcomes.


STUDY DESIGN
This longitudinal cohort study used birth certificates of siblings born to the same biological mother, with at least one previous birth and a subsequent singleton pregnancy. Adverse pregnancy outcomes included preterm delivery, very preterm birth, small for gestational age (SGA), very SGA (VSGA), early neonatal death and major congenital malformations. Multivariate logistic regression was performed for each outcome.


RESULTS
The study included 440,838 of a total of 846,845 reported live births in Israel over 5 years; excluded were primiparas (32%), multifetal births (4.9%) and those with incomplete data (10.9%). For IPIs shorter than 6 months, there were significantly increased risks for preterm birth (OR=1.23), SGA (OR=1.14), VSGA (OR=1.15), early neonatal death (OR=1.62) and congenital malformations (OR=1.14). Intervals of 60 months or longer had higher risks for preterm birth (OR=1.39) and VSGA (OR=1.16).


CONCLUSION
Optimal IPI recommendation of >11 months is an accessible and low-cost means to improve multiple adverse perinatal outcomes.
An update to the systematic literature review of empirical evidence of the impacts and outcomes of computer games and serious games

Continuing interest in digital games indicated that it would be useful to update [Authors’, 2012] systematic literature review of empirical evidence about the positive impacts an d outcomes of games. Since a large number of papers was identified in th e period from 2009 to 2014, the current review focused on 143 papers that provided higher quality evidence about the positive outcomes of games. [Authors’] multidimensional analysis of games and t heir outcomes provided a useful framework for organising the varied research in this area. The mo st frequently occurring outcome reported for games for learning was knowledge acquisition, while entertain me t games addressed a broader range of affective, behaviour change, perceptual and cognitive and phys iological outcomes. Games for learning were found across varied topics with STEM subjects and health the most popular. Future research on digital games would benefit from a systematic programme of experi m ntal work, examining in detail which game features are most effective in promoting engagement and supporting learning.
Effect of medication review and cognitive behaviour treatment by community pharmacists of patients discharged from the hospital on drug related problems and compliance: design of a randomized controlled trial

BACKGROUND
Drug related problems (DRPs) are common among elderly patients who are discharged from the hospital and are using several drugs for their chronic diseases. Examples of drug related problems are contra-indications, interactions, adverse drug reactions and inefficacy of treatment. Causes of these problems include prescription errors and non-compliance with treatment. The aim of this study is to examine the effect of medication review and cognitive behaviour therapy of discharged patients by community pharmacists to minimize the occurrence of drug related problems.


METHODS/DESIGN
A randomized controlled trial will be performed. Community pharmacists will be randomized into a control group and an intervention group. 342 Patients, aged over 60 years, discharged from general and academic hospitals, using five or more prescription drugs for their chronic disease will be asked by their pharmacy to participate in the study. Patients randomized to the control group will receive usual care according to the Dutch Pharmacy Standard. The medication of patients randomised to the intervention group will be reviewed by the community pharmacist with use of the national guidelines for the treatment of diseases, when patients are discharged from the hospital. The Pharmaceutical Care network Europe Registration form will be used to record drug related problems. Trained pharmacy technicians will counsel patients at home at baseline and at 1,3,6,9 and 12 months, using Cognitive Behaviour Treatment according to the Theory of Planned Behaviour. The patient's attitude towards medication and patient's adherence will be subject of the cognitive behaviour treatment. The counselling methods that will be used are motivational interviewing and problem solving treatment. Patients adherence towards drug use will be determined with use of the Medication Adherence Report Scale Questionnaire. There will be a follow-up of 12 months.The two primary outcome measures are the difference in occurrence of DRPs between intervention and control group and adherence with drug use. Secondary endpoints are attitude towards drug use, incidence of Re-hospitalisations related to medicines, functional status of the patient, quality of life and the cost-effectiveness of this intervention.


DISCUSSION
Combining both medication review and Cognitive Behaviour Treatment may decrease DRPs and may result in more compliance with drug use among patients discharged from the hospital and using 5 or more chronic drugs.


TRIAL REGISTRATION
Dutch Trial Register NTR1194.
Single-Image Depth Perception in the Wild

This paper studies single-image depth perception in the wild, i.e., recovering depth from a single image taken in unconstrained settings. We introduce a new dataset “Depth in the Wild” consisting of images in the wild annotated with relative depth between pairs of random points. We also propose a new algorithm that learns to estimate metric depth using annotations of relative depth. Compared to the state of the art, our algorithm is simpler and performs better. Experiments show that our algorithm, combined with existing RGB-D data and our new relative depth annotations, significantly improves single-image depth perception in the wild. Deep Network with Pixel-wise Prediction Metric Depth RGB-D Data Relative Depth Annotations
Analysis and Experimental Verification of a Three-Dimensional Noncontacting Angular Motion Sensor

A three-dimensional noncontacting angular motion sensor, based on magnetometry, has been developed for velocity feedback in the ball wheel mechanism, which serves as the drivetrain for a class of omnidirectional mobile platforms. More generally, this scheme tracks rigid-body rotation about a fixed point with an undefined axis of rotation. The approach involves tracking the time-varying magnetic field of a permanent disc magnet embedded at the center of the sphere. This data is then used to determine the absolute orientation of the magnet axis. Finally, an approach based on the natural invariants of rigid-body motion is used to determine the instantaneous axis of rotation and the angular speed of the sphere about this axis. In this paper, the sensing scheme is formulated, effects of geometric offsets within the tri-axial fluxgate magnetometer are addressed, and results from experimental verification are presented.
Differential Brain Development with Low and High IQ in Attention-Deficit/Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder (ADHD) and intelligence (IQ) are both heritable phenotypes. Overlapping genetic effects have been suggested to influence both, with neuroimaging work suggesting similar overlap in terms of morphometric properties of the brain. Together, this evidence suggests that the brain changes characteristic of ADHD may vary as a function of IQ. This study investigated this hypothesis in a sample of 108 children with ADHD and 106 typically developing controls, who participated in a cross-sectional anatomical MRI study. A subgroup of 64 children also participated in a diffusion tensor imaging scan. Brain volumes, local cortical thickness and average cerebral white matter microstructure were analyzed in relation to diagnostic group and IQ. Dimensional analyses investigated possible group differences in the relationship between anatomical measures and IQ. Second, the groups were split into above and below median IQ subgroups to investigate possible differences in the trajectories of cortical development. Dimensionally, cerebral gray matter volume and cerebral white matter microstructure were positively associated with IQ for controls, but not for ADHD. In the analyses of the below and above median IQ subgroups, we found no differences from controls in cerebral gray matter volume in ADHD with below-median IQ, but a delay of cortical development in a number of regions, including prefrontal areas. Conversely, in ADHD with above-median IQ, there were significant reductions from controls in cerebral gray matter volume, but no local differences in the trajectories of cortical development.In conclusion, the basic relationship between IQ and neuroanatomy appears to be altered in ADHD. Our results suggest that there may be multiple brain phenotypes associated with ADHD, where ADHD combined with above median IQ is characterized by small, more global reductions in brain volume that are stable over development, whereas ADHD with below median IQ is associated more with a delay of cortical development.
Parser Extraction of Triples in Unstructured Text

The web contains vast repositories of unstructured text. We investigate the opportunity for building a knowledge graph from these text sources. We generate a set of triples which can be used in knowledge gathering and integration. We define the architecture of a language compiler for processing subjectpredicate-object triples using the OpenNLP parser. We implement a depth-first search traversal on the POS tagged syntactic tree appending predicate and object information. A parser enables higher precision and higher recall extractions of syntactic relationships across conjunction boundaries. We are able to extract 2-2.5 times the correct extractions of ReVerb. The extractions are used in a variety of semantic web applications and question answering. We verify extraction of 50,000 triples on the ClueWeb dataset. Keywords— Open information extraction, Relation extraction, NLP
Cognitive radio network architecture: part II - trusted network layer structure

Cognitive radios shall form cognitive radio network (CRN) to complete the packets delivery. As cognitive radio network is a general multihop wireless heterogeneous network, trust becomes a critical factor for network layer functions and network operation. We explore and develop the mathematical framework of trust in CRN, to further develop trusted routing with relevant explorations on network layer and above functions.
Class III beta-tubulin isotype predicts response in advanced breast cancer patients randomly treated either with single-agent doxorubicin or docetaxel.

PURPOSE
To evaluate the role of microtubule-associated variables as potential predictors of response and clinical outcome in patients with advanced breast cancer receiving single-agent docetaxel or doxorubicin chemotherapy.


EXPERIMENTAL DESIGN
The analysis was done on 173 tumor samples from patients with locally advanced or metastatic breast cancer who have participated in the TAX-303 phase III trial in which patients were randomly assigned to receive docetaxel or doxorubicin. Expression of total alpha- and beta-tubulin, classes II to IV beta-tubulin isotypes, and tau protein was evaluated by immunohistochemistry on formalin-fixed, paraffin-embedded tumors from the primary breast cancer.


RESULTS
We observed that patients with "high" expression of class III beta-tubulin isotype had a higher probability of response to docetaxel than to doxorubicin treatment (odds ratio, 1.9; 95% confidence interval, 1.01-3.7; P = 0.05). No difference was observed in terms of time to progression or in terms of overall survival.


CONCLUSIONS
This study suggests that the superiority of docetaxel over doxorubicin seems to be confined to the subgroup of patients with "high" expression of class III beta-tubulin isotype.
What is the present-day status of The Copernican Principle?

I point out that according to the Copernican principle our universe is not unique. The way to make sense out of this statement is for us to construct a gravitational instanton that will tunnel out of our vacuum into another, to form a universe other than our Hubble bubble.
Control of variable geometry turbocharged diesel engines for reduced emissions

A multivariable control scheme is designed to minimize emission of nitrogen oxides NOx and generation of smoke in a Diesel engine equipped with a variable geometry tur bocharger VGT and an external exhaust gas recirculation system EGR Steady state optimization results in operat ing points where NOx emissions and smoke generation are highly coupled and require joint management by VGT and EGR actuators
Peripherally acting NMDA receptor/glycineB site receptor antagonists inhibit morphine tolerance

The present study focused on the role of peripheral ionotropic N-methyl-D-aspartate (NMDA) receptors in the development of tolerance to morphine-induced antinociception. An initial experiment revealed that NMDA channel blocker memantine, and NMDA receptor/glycine(B) site antagonist MRZ 2/576 inhibited maximal electroshock-induced convulsions (MES) in female NMR mice with respective potency of 5.93 and 20.8 mg/kg, while other NMDA receptor/glycine(B) site antagonists MRZ 2/596 and MDL 105,519 were ineffective, supporting lack of CNS activity of the latter two agents. This observation was also supported by blood-brain barrier experiments in vitro. In male Swiss mice, morphine (10 mg/kg) given for 6 days twice a day (b.i.d.) produced tolerance to its antinociceptive effects in the tail-flick test. The NMDA receptor/glycine(B) site antagonists, MRZ 2/576 at 0.03, 0.1, 0.3 mg/kg and MRZ 2/596 at 0.1, 0.3, 3 and 10 mg/kg attenuated the development of morphine tolerance. Similarly, in male C57/Bl mice, morphine (10 mg/kg) given for 6 days b.i.d. produced tolerance to its antinociceptive effects in the tail-flick test. Like in Swiss mice, in C57/Bl mice morphine tolerance was attenuated by both MRZ 2/576 and MRZ 2/596. Another NMDA receptor/glycine(B) site receptor antagonist, MDL 105,519 (that very weakly penetrates to the central nervous system) also inhibited morphine tolerance at the dose of 1 but not 0.1 mg/kg. Moreover, both naloxone hydrochloride (5 and 50 mg/kg) and centrally inactive naloxone methiodide (50mg/kg) inhibited morphine tolerance suggesting the involvement of peripheral opioid receptors in this phenomenon. The present data suggest that blockade of NMDA receptor/glycine(B) sites in the periphery may attenuate tolerance to the antinociceptive effects of morphine.
Security and Privacy Issues in IoT

Internet of Things (IoT) is a global network of phy sical and virtual ‘things’ connected to the internet. Eac h object has unique ID which is used for identification. IoT is the emerging technology which will change the way we interact wi h devices. In future almost every electronic device will be a sma rt device which can compute and communicate with hand-held and othe r infrastructure devices. As most of the devices may be battery operated, due to less processing power the security and privacy is a major issue in IoT. Authentication, Identification and device heterogeneity are the major security and privacy co ncerns in IoT. Major challenges include integration, scalability, ethics communication mechanism, business models and survei llance. In this paper major issues related to security and pri vacy of IoT are focused.
Study of a wireless power transmission system for an active capsule endoscope.

BACKGROUND
An active capsule endoscope (ACE) will consume much more energy than can be power by batteries. Its orientation and position are always undetermined when it continues the natural way down the gastrointestinal track.


METHODS
In order to deliver stable and sufficient energy to ACE safely, a wireless power transmission system based on inductive coupling is presented. The system consists of a Helmholtz primary coil outside and a multiple secondary coils inside the body. The Helmholtz primary coil is driven to generate a uniform alternating magnetic field covering the whole of the alimentary tract, and the multiple secondary coils receive energy regardless of the ACE's position and orientation relative to the generated magnetic field. The human tissue safety of the electromagnetic field generated by transmitting coil was evaluated, based on a high-resolution realistic human model.


RESULTS
At least 310 mW usable power can be transmitted under the worst geometrical conditions. Outer dimensions of the power receiver, 10 mm diameter x 12 mm; transmitting power, 25 W; resonant frequency, 400 kHz. The maximum specific absorption rate (SAR) and current density of human tissues are 0.329 W/kg and 3.82 A/m(2), respectively, under the basic restrictions of the International Commission on Non-ionizing Radiation Protection (ICNIRP).


CONCLUSIONS
The designed wireless power transmission is shown to be feasible and potentially safe in a future application.
Understanding the information and service needs of young adults with chronic pain: perspectives of young adults and their providers.

OBJECTIVE
To qualitatively explore the information and service needs of young adults (YAs) with chronic pain to inform the development of a web-based chronic pain self-management program.


METHODS
A convenience sample of YAs (n=17; aged 18 to 29 y) with chronic pain was recruited from 2 adult tertiary care multidisciplinary chronic pain clinics in Ontario. Interdisciplinary health care professionals who had worked in chronic pain for at least 1 year were also recruited from these sites. Five audiotaped focus groups were conducted, 3 for YAs and 2 for health care professionals. Transcribed data were organized into categories that reflected emerging themes.


RESULTS
Findings uncovered 4 major themes: (1) pain impact, (2) pain management strategies, (3) barriers to care, and (4) service delivery recommendations. Subthemes were found under each major theme. Pain had an impact on social and emotional realms and role functioning, physical functioning, and future vocational and life goals. Pain management strategies were comprised of psychological, physical, and pharmacological approaches and development of support systems. Barriers to care were revealed at the patient, health care system, and societal levels. Finally, service delivery recommendations were divided into 2 subthemes pertaining to improved services and Internet-based programs.


DISCUSSION
Participants unanimously felt that a web-based program would be an acceptable means to help improve access to services and meet the need for more information about chronic pain, strategies to manage pain symptoms, and social support to address the unique developmental needs of YAs.
Striped Circle Visual Acuity Chart; A Novel Visual Acuity Chart Based on the Landolt-C Chart

Measurement of Visual Acuity (VA) has been used for eye examinations under various clinical conditions. In addition, because of changes in VA with a range of eye diseases, its measurement is used to screen, diagnose, and evaluate response to treatment in numerous eye diseases and predict the patient's visual function. VA and the likelihood of astigmatism could be evaluated simultaneously using a newly designed Stripped Circle (SC) VA chart. This chart has been developed based on the standard VA measurement scale chart, and the Landolt-C (LC) VA chart and all the standards for a VA chart design were implemented during its development. However, to publicize the clinical application of this VA measurement chart, further studies are required to evaluate its sensitivity, specificity, and repeatability compared with a similar standard VA chart.
A Production Oriented Approach for Vandalism Detection in Wikidata - The Buffaloberry Vandalism Detector at WSDM Cup 2017

Wikidata is a free and open knowledge base from the Wikimedia Foundation, that not only acts as a central storage of structured data for other projects of the organization, but also for a growing array of information systems, including search engines. Like Wikipedia, Wikidata’s content can be created and edited by anyone; which is the main source of its strength, but also allows for malicious users to vandalize it, risking the spreading of misinformation through all the systems that rely on it as a source of structured facts. Our task at the WSDM Cup 2017 was to come up with a fast and reliable prediction system that narrows down suspicious edits for human revision [8]. Elaborating on previous works by Heindorf et al. we were able to outperform all other contestants, while incorporating new interesting features, unifying the programming language used to only Python and refactoring the feature extractor into a simpler and more compact code base.