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1,044 | Despite metabolic and reproductive phenotypes also being observed in grand-offspring fathered via the male offspring lineage, there was no evidence that any of the 13 microRNAs were also dysregulated in male offspring sperm. | 6 | train |
1,045 | Overall cancer incidence rates decreased by approximately 1% per year; the decrease was statistically significant (P < .05) in women, but not in men, because of a recent increase in prostate cancer incidence. | 5 | test |
1,046 | Tdp-43, while not a stand-alone explanation, is a large contributor to that phenomenon. | 4 | train |
1,047 | Heavy alcohol intake at ages 15-19 was not associated with overall prostate cancer; however, consumption of at least seven drinks per week during this age was associated with 3.2 times the odds of high-grade prostate cancer compared with non-drinkers. | 5 | train |
1,048 | Although the amphibians are obvious at close range, their colors and patterns merge into the rainforest background as viewing distance increases. | 5 | val |
1,049 | Cannabis did not cause any harmful changes in virus levels in patients. | 6 | test |
1,050 | Reducing the amount of financial information displayed resulted in selection of lower-cost plans; this was not accompanied by a decrease in the average plan quality or pharmacy network size but did correlate with an increase in the take-up of convenience options, including mail-order pharmacy. | 6 | train |
1,051 | The derivatives were as elusive to resistance as the original amphotericin b, thus proving that targeted drugs and low resistance are not mutually exclusive. | 5 | train |
1,052 | It is not one species -- but three. | 6 | train |
1,053 | The process by which ipscs are created is not simply a reversal of how skin cells are generated in normal human development. | 5 | val |
1,054 | Grievances and religious beliefs, on the other hand, are necessary yet insufficient conditions for such actions. | 5 | train |
1,055 | As acknowledged in the article, validated biomarkers or companion diagnostics are not always present. | 5 | train |
1,056 | The protein is not actually necessary for the development and function of myeloid progenitor cells, either in vitro or in vivo in mice. | 6 | train |
1,057 | Whilst there is a link between rising co2 levels and mosquito evolution, it is less directly linked than previously thought, with other factors, such as the diversity of mammal hosts, contributing to an increase in the species richness of mosquitos. | 4 | train |
1,058 | CONCLUSIONS The combination of bicalutamide and everolimus has encouraging efficacy in men with bicalutamide-naive CRPC, thus warranting further investigation. | 5 | train |
1,059 | The dogs were sensitive to the polarity of the field, though not as much to its intensity. | 4 | train |
1,060 | Further research is, therefore, necessary to explore the underlying mechanism(s) of these associations. | 1 | train |
1,061 | There were no statistically significant differences in change of scores for participants randomized to receive supplements vs those who were not. | 5 | train |
1,062 | There is no one-size-fits-all explanation and that the details of each structure are uniquely tied to the chemical details of the molecules that comprise it. | 5 | train |
1,063 | While the rates of diagnostic ct did increase substantially during that time period, the changes varied considerably according to age group and anatomical region. | 5 | train |
1,064 | At database lock and based on 92 deaths, no difference in overall survival was noted between linsitinib and placebo (median 323 days [95% CI 256–507] vs 356 days [249–556]; hazard ratio 0·94 [95% CI 0·61–1·44]; p=0·77). | 6 | train |
1,065 | The structure of the nanowires in the polymer is not changed, but that the conductivity of the mesh even improves thanks to the compression by the polymer, as the polymer contracts during the curing process. | 6 | val |
1,066 | Unbiased univariate analysis did not reveal differences in the hippocampus between remembering and imagining; however, multivariate analyses revealed evidence that patterns of activity within the hippocampus distinguish between remembering and imagining. | 6 | train |
1,067 | Although mir-132 is not a protein itself, it masters activation of immune cells by harnessing the protein-making super engines of the cell called ribosomes. | 5 | val |
1,068 | We found no statistically significant dose-response in change in cMFTC cartilage thickness. | 6 | train |
1,069 | All other SNPs were not significantly associated with BMD. | 6 | train |
1,070 | Not all parts of memory develop at the same pace in children. | 5 | train |
1,071 | There are no data which demonstrate that these pathogens are harmless to humans. | 6 | train |
1,072 | Neither completely validated delirium screening instruments nor an ideal schedule to perform delirium assessments exist there. | 6 | train |
1,073 | Recent advances in the measurement of exposure biomarkers hold much promise in improving the epidemiological data, but their utility must be understood to facilitate appropriate study design. | 6 | train |
1,074 | The MLR model demonstrated the area under curve (AUC) values for receiver operating characteristic (ROC) are not lower than 0.92 and 0.60 for notMNIST and CGCL, respectively. | 5 | train |
1,075 | Unlike its modulation at cation-selective pLGICs, bupropion displayed no significant inhibition of the function of anion-selective pLGICs. | 6 | train |
1,076 | Education is a necessary but not a sufficient condition for growth. | 5 | train |
1,077 | Coherent twin boundaries are not so perfect after all. | 5 | train |
1,078 | There were no differences between groups in time until parasitemia by microscopy or quantitative polymerase chain reaction, parasite kinetics, clinical symptoms, or laboratory values. | 5 | test |
1,079 | Forcing manufacturers to meet those standards, and routinely checking to ensure they do, is enough, although the fda clearly disagrees. | 4 | train |
1,080 | Moreover, transfusion of platelets without ITAM receptor function or platelets lacking the adapter protein SLP-76 into TP mice had no significant effect on vascular integrity during inflammation. | 5 | train |
1,081 | Five women (1%) had a multiple pregnancy following iui-fsh and eight (2%) had a multiple pregnancy following iui-cc - again, a statistically non-significant difference. | 5 | train |
1,082 | The beneficial association of an ASC did not vary differentially by student race/ethnicity. | 6 | train |
1,083 | Zymography results showed no significant upregulation of cathepsins or matrix metalloproteinases in tendon or cartilage at 2 or 10 weeks of overuse compared to controls. | 5 | val |
1,084 | The practice does not have enough evidence to support its effectiveness. | 2 | train |
1,085 | The trend matches neatly with models of human-influenced global warming, and thus cannot be attributed to natural variability. | 6 | train |
1,086 | In addition, Δ 9 -THC reduced total signal power during both active drug conditions compared with placebo, but no relationship was detected between signal power and psychosis-like symptoms. | 6 | train |
1,087 | The difference in publication rates could not be explained by the size of the study (how many participants were involved) or the specific cognitive tasks the participants were asked to do. | 6 | train |
1,088 | Is not the case with the highly pathogenic flu viruses that are associated with more severe illness. | 5 | train |
1,089 | The number of PSA tests per ambulatory visit, the number of referrals per ambulatory visit, the age at the time of the urology referral, and the proportion of PSA tests performed outside the recommended age range did not significantly change. | 5 | train |
1,090 | The eggs of such mothers lead to heavier-than-normal fetuses with greatly reduced amounts of mitochondrial dna and other obvious signs of damage,aeur she says. | 5 | train |
1,091 | Healthy people do not need to be vaccinated. | 6 | test |
1,092 | In asthma, the opposite is true. | 6 | train |
1,093 | The alearn-by-descriptiona hypothesis must be incorrect and that blind people must gather visual information in a different way: by deducing it from existing knowledge about an object and details related to it. | 6 | train |
1,094 | While productivity gains are a necessary condition for sustained real wage growth, they are not a sufficient condition. | 5 | train |
1,095 | Participants in the psychosocial and no‐contact conditions did not show any significant improvement. | 6 | train |
1,096 | The baseline-adjusted annual rate of change in the aortic-root z score did not differ substantially between the losartan and atenolol groups: -0.107 +- 0.013 and -0.139 +- 0.013 standard deviation units, respectively (p = .08). | 5 | train |
1,097 | Administration of high-dose vitamin d3 did not significantly lower hospital stay, intensive care unit duration, hospital mortality, or the risk of death at 6 months among those with insufficient levels of vitamin d who were critically ill. | 5 | test |
1,098 | No significant effect on bradykinin-induced vasorelaxation with and without l-NAME was observed. | 6 | train |
1,099 | These findings are not a fluke. | 6 | train |
1,100 | Variation in cost per dose and doses administered across facilities, districts and states need to be further investigated to understand the drivers of cost and measure the efficiency of service delivery. | 1 | test |
1,101 | While some forms of imaging were widely available, not all were available everywhere:. | 5 | test |
1,102 | The new technology provided by pbmdas merely represents a new arena for short-term sexual behavior, and not necessarily a facilitator of new sexual behaviors.a. | 5 | train |
1,103 | M3-9-m (mhc i high) but not 76-9 (mhc i low) tumors respond to oncolytic herpes simplex virus-1 (ohsv-1) and pd-1 blockade combination therapy. | 6 | train |
1,104 | Population growth was not directly correlated to emissions growth. | 5 | train |
1,105 | There were no changes during exercise in the rate of appearance compared with rest in the H-CHO group. | 6 | test |
1,106 | At 1-year follow-up, there were no statistical differences between the experimental and control groups with regard to primary outcome measure of low back pain ( P = 0.183), leg pain ( P = 0.075), and function ( P = 0.365). | 5 | train |
1,107 | Ag-rh alloy nanoparticles are not merely a mixture of ag and rh at a microscopic level, but are a merging of the two elements at the atomic level, and that their electronic structure is nearly identical to that of pd. | 6 | train |
1,108 | The density number of both modes of particles is not that high. | 5 | train |
1,109 | More is not necessarily better, because simply having many species does not insure against ecosystem collapse. | 4 | train |
1,110 | Although aleglitazar reduced glycated hemoglobin and improved serum hdl-c and triglyceride levels, the drug did not decrease the time to cardiovascular death, nonfatal heart attack, or nonfatal stroke (primary end points). | 6 | train |
1,111 | Limiting the global mean temperature increase to 1.5deg celsius is neither a geophysical impossibility, nor a technical fantasy. | 6 | train |
1,112 | The overall drop in sugary drink sales came to 38 percent, a not-insignificant amount. | 5 | val |
1,113 | Healthy nonsmokers experienced increased adrenaline levels in their heart after one electronic cigarette (e-cigarette) with nicotine but there were no increased adrenaline levels when the study subjects used an a nicotine-free or empty e-cig. | 5 | train |
1,114 | Not all strains of bacteria fight the same way. | 5 | train |
1,115 | There is no evidence that the mean photometric and spectroscopic properties of SLSNe-I differ between low (z 〈 1) and high redshift (z 〉 1), but there is clear evidence of diversity in the spectrum at λ_(rest) 〈 2000 A, possibly caused by the variations in temperature between events. | 6 | train |
1,116 | Their initial report for the period through 1990 offered the caveats that the decline was more limited in large cities of the Northeast and Midwest and that “there are more completely black areas in our cities than there have ever been in the past, and large amounts of segregation linger” (Cutler, Glaeser and Vigdor 1999, p. 496). | 6 | train |
1,117 | Eukaryotes reveal no detectable cumulative effects of LGT, though prokaryotes do. | 5 | train |
1,118 | There is no statistically significant difference in the sexual behavior between people who are living in the sub-african countries receiving funds from united states for abstinence education and people living in countries that do not receive any funds at all. | 5 | train |
1,119 | Although similar in direction, there was no statistically significant association between depression and AUD (PR = 1.41; 95% CI = 0.94, 2.11). | 5 | train |
1,120 | Because suitable biomarkers of long-term exposure do not exist for many common FRs, and levels of FRs in dust are significantly correlated with exposure, relationships between FRs in household dust and PTC were evaluated in addition to available biomarkers. | 5 | train |
1,121 | Further investigation is warranted to elucidate factors that influence the management of low-risk prostate cancer, including individual treatment center patterns. | 5 | train |
1,122 | There was no relationship between the number of reviews and its rating. | 6 | train |
1,123 | With a median follow-up of 36.7 months, the median overall survival from the date of the first randomization was not significantly different between chemotherapy at 16.5 months (95% CI, 14.5-18.5 months) and chemoradiotherapy at 15.2 months (95% CI, 13.9-17.3 | 5 | train |
1,124 | The same is true for how the brain understands the environments around us. | 5 | train |
1,125 | The two are not at all correlated. | 6 | train |
1,126 | We did not obtain any mutants of Staphylococcus aureus or Mycobacterium tuberculosis resistant to teixobactin. | 6 | train |
1,127 | There is no such thing as a sugar rush. | 6 | train |
1,128 | Research has identified one such abstract property in the domain of word order: Although sentence word-order preferences vary across languages, the superficially different orders result in short grammatical dependencies between words. | 5 | val |
1,129 | Thereaeur(tm)s no such thing as a male or female brain. | 6 | train |
1,130 | We found no evidence of a temporal relationship between cannabis use and pain severity or pain interference, and no evidence that cannabis use reduced prescribed opioid use or increased rates of opioid discontinuation. | 6 | train |
1,131 | Adjustment for systolic blood pressure, diabetes, body mass index, and physical activity had no notable impact. | 5 | val |
1,132 | Prostasin zymogen conversion to active prostasin is dependent on matriptase but does not require matriptase zymogen conversion. | 5 | train |
1,133 | Using within-student variation in home computer access, and across-ZIP code variation in the timing of the introduction of high-speed internet service, we also demonstrate that the introduction of home computer technology is associated with modest but statistically significant and persistent negative impacts on student math and reading test scores. | 5 | train |
1,134 | Not all sites are equal and successful implementation of ccs requires careful appraisal. | 5 | train |
1,135 | Self-regulation did not influence NPS responses; instead, its effects were mediated through functional connections between the nucleus accumbens and ventromedial prefrontal cortex. | 6 | train |
1,136 | The temperature females were kept at before and after mating had no impact on levels of brown adipose tissue in their offspring, but this was not the case for males: the offspring of males kept in a cool environment for several days prior to mating had more active brown adipose tissue than those of males kept in a temperate environment. | 6 | train |
1,137 | In contrast, pharmacologic or genetic activation of HIF via HIF prolyl-hydroxylase inhibition protected wild-type animals from ischemic kidney injury and inflammation; however, these same protective effects were not observed in HIF prolyl-hydroxylase inhibitor–treated animals lacking endothelial HIF-2. | 6 | train |
1,138 | Median docetaxel PFS for gDDRm+ (6.8 mo) was not significantly different from that for gDDRm– (5.1 mo), and RRs were similar (gDDRm+=61%; gDDRm–=54%). | 5 | train |
1,139 | While infants use memory to learn language and make sense of the world around them, they do not yet have the sophisticated neural architecture needed to form and hold onto more complex forms of memory. | 5 | train |
1,140 | When the to-be-ignored color changed from trial to trial, no RT benefit was observed. | 6 | train |
1,141 | The hhex protein is overexpressed in acute myeloid leukemia (aml) cells and is necessary for their propagation but not for normal myelopoiesis. | 6 | train |
1,142 | Further investigations are warranted into the risk factors and treatment of AI-induced CTS. | 6 | train |
1,143 | Additional research is needed in this area. | 6 | train |