[DOC] [TLE] Vincent Dole - Wikipedia [PAR] Vincent Dole (18 May 1913 in Chicago  1 August 2006) was an American doctor
, who, along with his wife Dr Marie Nyswander (died 1986), pioneered the 
practice of using the synthetic narcotic agonist methadone to treat heroin 
addiction. Drs. Dole & Nyswander, in establishing Methadone maintenance 
treatment ... on the conventional and widely held view (circa 1965) that narcotic 
addiction... [DOC] [TLE] Dr. Vincent Dole (1913-2006) on Methadone Maintenance ... [PAR] Oct 30, 2015 ... In 1964, Dr. Vincent Dole and two colleagues, Dr. Marie Nyswander ... 
methadone maintenance in the treatment of heroin addiction. ... This medication 
[methadone] given in fixed dose to tolerant subjects, does not make patients 
high or ... just sitting and talking with the addicts in a somewhat aimless way. [DOC] [TLE] The First Pharmacological Treatment for Narcotic Addiction [PAR] Dole, Vincent; Nyswander, Marie; Kreek, Mary Jeanne. ... In early 1964, this team 
began studies with heroin addicts at the Rockefeller Hospital which, within six ... it 
prevents addicts from feeling any "high" from an injection of heroina ... In 1965, 
translational studies of methadone maintenance treatment involving additional... [DOC] [TLE] Methadone Maintenance for Heroin Addicts - Yale Law School ... [PAR] search begun in January 1964 by Dr. Vincent Dole and Dr. Marie ... Dole and 
Nyswander see methadone main- ... (1965); TASK FORCE ON NARcoIcS AND 
DRUG ABUSE, THE ... Methadone Maintenance Treatment of Heroin Addiction: 
Beginning ... use with blockade treatment was not enough to open the way for 
social... [DOC] [TLE] 1965-71 - Alcohol and Drugs History Society [PAR] nance, an outpatient drug treatment for heroin addiction.1 The early 1970s were 
a ... and penitentaries.4 Methadone, which had been in use as an aid for detoxifi- 
... neer Vincent Dole and his partner Marie Nyswander developed their treatment 
.... By 1970 Synanon had turned away from its rehabilitative mission and had. [DOC] [TLE] Vincent P. Dole - The Rockefeller University  Awards & Honors [PAR] Studying one of the most formidable addictions  heroin  Vincent P. Dole, ... 
new way of approaching addiction  as a medical problem, with a medical 
answer. ... Dr. Dole, along with his colleagues Marie Nyswander (later his wife) 
and Mary ... methadone can also be cross-tolerant: Treated with a high enough 
dose, the... [DOC] [TLE] Dr Vincent Dole | The Independent [PAR] Aug 11, 2006 ... Vincent Paul Dole, physician: born Chicago 18 May 1913; MD 1939; staff, ... 1965 
Marie Nyswander (died 1982), 1992 Margaret MacMillan Cool; died ... he 
introduced the concept of treating heroin addiction with methadone, ... He 
returned to Rockefeller in 1947 to study patients with high blood pressure. [DOC] [TLE] Methadone Maintenance Treatment and Clinical Issues 1 - National ... [PAR] Maintenance with low doses of morphine was administered to the first two 
patients ... 1965; Dole, Nyswander & Kreek, 1966; Gordon, 1970; Joseph & Dole, 
1970; Kreek, ... The applicants had to be addicted to heroin for at least four years 
and have ...... treatment, developed by Drs. Vincent Dole and Marie Nyswander in 
the... [DOC] [TLE] Methadone in the Treatment of Narcotic Addiction [PAR] Interview With Vincent P. Dole ... Ways Of Easing Reductions ... As a psychiatrist, 
Marie Nyswander had worked with drug addicts during the 1950s, ... now 
available in many developed countries where heroin injecting has become 
prevalent. ... These include the use of high dose methadone (>100mg daily) 
where necessary... [DOC] [TLE] Why methadone maintenance works [PAR] Methadone is legal; hence the addict who enters a methadone maintenance 
program ... In fact, several nonaddicting drugs for the treatment of heroin 
addiction have ... and depression, with a continuing craving for heroin and no 
way to assuage .... Vincent P. Dole and Marie E. Nyswander, "Rehabilitation of 
Heroin Addicts... [DOC] [TLE] Justifying drug substitution therapies: The case of methadone ... [PAR] methadone maintenance was an effective treatment for heroin dependence and 
their ... treatment. The first was put

Question: In 1965 Vincent Dole & Marie Nyswander developed a way of treating heroin addicts using high doses of this
Answer: methadone