[DOC] [TLE] Classic Profile: Brown and Goldstein: The Cholesterol Chronicles [PAR] Aug 26, 2013 ... Heterozygous patients have twice the normal blood levels of a ... people and can 
send LDL levels soaring six-times above normal, ... for two decades on mammary 
artery implants, and both his parents had suffered cardiovascular symptoms. ... 
Next, Brown and Goldstein set out to find whether skin cells of... [DOC] [TLE] 2 AMERICANS WIN NOBEL MEDICINE PRIZE - NYTimes.com [PAR] Oct 15, 1985 ... Two Americans, Michael S. Brown and Joseph L. Goldstein, won the 1985 ... 
found that cells of the human body have receptors on their surfaces that trap and 
... levels of fatty cholesterol accumulate to clog human arteries and cause ... flaw 
in those people who suffer from inherited high-cholesterol afflictions. [DOC] [TLE] fatal genetic flaw offers 'human lab' to test theories on cholesterol [PAR] Nov 10, 1981 ... The doctors, Michael S. Brown and Joseph L. Goldstein of the ... highly 
susceptible to clogging of the arteries (atherosclerosis) and an early ... More than 
93 percent of the cholesterol in the human body is found ... only half the normal 
number of LDL receptors and that homozygotes produced almost none. [DOC] [TLE] Endo, Akira - Science Heroes [PAR] Akira Endo is the medical research scientist who discovered the first statin ... 
They work by limiting cholesterol synthesis within the liver and have proved to be 
a much .... Michael Brown and Joseph Goldstein, Nobel Prize winners for their 
work on .... Despite two normal LDL receptor genes, two out of three people in 
Western... [DOC] [TLE] Free Flashcards about MEDICINE - StudyStack [PAR] BROWN & GOLDSTEIN FOUND THAT PEOPLE WITH FEW LDL RECEPTORS 
HAVE HIGH LEVELS OF THIS ARTERY CLOGGER, CHOLESTEROL. NORMAN
... [DOC] [TLE] Physiology or Medicine 1985 - Press Release - Nobelprize.org [PAR] Brown and Goldstein have discovered that the underlying mechanism to the ... As 
a consequence the number of LDL-receptors on the cell surface is reduced. This 
leads to increased levels of cholesterol in the blood which subsequently may ... 
wall of arteries causing atherosclerosis and eventually a heart attack or a stroke. [DOC] [TLE] HHMI Bulletin: Cholesterol - A Century of Research - UT Southwestern [PAR] Over the course of nearly a century of investigation, researchers have developed 
... contained 20- to 26-fold higher concentrations of cholesterol than did normal 
aortas. ... rather than the coronary artery plaques that are responsible for heart 
attacks. ... We also found that FH is caused by genetic defects in this receptor that
... [DOC] [TLE] Download this transcript - PDF (English - US) [PAR] This is extremely serious not to have your heart pumping, as you all know. ... here
: if they become clogged and the arterial wall gets build ups here, we have .... But 
how was it that people came to know this, to find these receptors? ... In terms of 
heart attacks, normal individuals would have heart attacks at the normal age. [DOC] [TLE] Will a statin a day really keep the doctor away? | Cosmos [PAR] Dec 29, 2014 ... Plenty of healthy people like Browning have been prescribed statins to lower ... 
cholesterol levels statins save lives in people with clogged arteries. ... That 
compelling logic has seen doctors prescribe statins to healthy people with high ... 
Until 2011, Cochrane researchers found no clear benefits to using... [DOC] [TLE] How statin drugs really lower cholesterol & kill you one cell at a time ... [PAR] Oct 25, 2013 ... The LDL receptors on each cell go into overdrive and try to 'receive' more ... 
Hence high LDL blood levels are the sign that someone has FH. ..... It has shown 
how a few key players  Steinberg, Endo, Brown and Goldstein could work ..... to 
keep his arteries healthy since he was recently found to be diabetic. [DOC] [TLE] plantpositive - 22 Cholesterol Confusion 5 Cholesterol Is Necessar [PAR] 26 Cholesterol Confusion 9 "Brown and Goldstein We ... KRESSER: I was just 
going to say, it's a shame how few people are aware of ... Read this slide and you 
will also see that one may have a normal cholesterol level and still have SLOS.

Question: Brown & Goldstein found that people with few LDL receptors have high levels of this artery clogger
Answer: cholesterol