[DOC] [TLE] Mycobacterium tuberculosis Pathogenesis and Molecular ... - NCBI [PAR] Tuberculosis (TB), one of the oldest known human diseases. is still is one of the 
... be used for creating vaccines and drugs as well as more selective diagnostic 
reagents. ... it by virtue of their exposure to cattle infected with the tubercle 
bacillus. ..... Guinea pigs are very sensitive to M. tuberculosis infection, and the 
stages of... [DOC] [TLE] Evolution of Drug Resistance in Mycobacterium tuberculosis - NCBI [PAR] Alternatively, low-level resistance can be caused by point mutations in the 
regulatory ... The risks of mutation for most of the antibiotics used in tuberculosis 
treatment ..... virulence and response to treatment with isoniazid in guinea pigs 
and mice. .... An outbreak of tuberculosis caused by multiple-drug-resistant 
tubercle bacilli... [DOC] [TLE] Perspectives on Clinical and Preclinical Testing of New ... - NCBI [PAR] The testing of new TB vaccines in mice or in guinea pigs may not detect important 
... In current preclinical TB vaccine evaluations, tubercle counting in rabbits has 
not ... Although the currently available BCG vaccines used in these trials were .... 
of tuberculosis in mice and guinea pigs, because their primary lesions would be... [DOC] [TLE] The Guinea Pig Virulence of Indian Tubercle Bacilli - ATS Journals [PAR] has been its ability to cause tuberculous disease in guinea ... tubercle bacilli 
injected into guinea pigs showed considerable ... 10 isoniazid-resistant strains of 
M. tuberculosis ... catalase activity (20) in order to detect catalase- ... The guinea 
pigs used were albinos weighing ..... Low guinea pig virulence observed in more. [DOC] [TLE] Multi-drug-resistant tuberculosis - Wikipedia [PAR] Multi-drug-resistant tuberculosis is defined as a form of TB infection caused by 
bacteria that are ... Because MDR tuberculosis is an airborne pathogen, persons 
with active, ... One of their studies found that 75% of newly diagnosed inmates 
with TB are .... Some of the ways the tubercle bacillus acquires drug resistance 
are:. [DOC] [TLE] THE INCIDENCE OF TUBERCLE BACILLI AND BRUCELLA ... [PAR] The value of [quot] low temperature [quot] or [quot] holder [quot] pasteurisa- tion 
for ... Two guinea- pigs were used for testing each sample of milk, except with ... 
TABLE II Examination of milk from tuberculin-tested herds for tubercle bacilli and 
.... titres in inoculated guinea-pigs ; (4) diagnosis of the disease in guinea-pigs by
... [DOC] [TLE] Guinea Pig Models and Uses in Research (Notes) - NetVet [PAR] Can be helpful in determining why some species are resistant. eg. ... Animal 
disease: Experimental Model - In guinea pigs. induced with degraded ... the 
respiratory route with small numbers of virulent tubercle bacilli, and a bacillemia 
ensues .... Guinea Pigs Are Used Extensively - because they are easily 
sensitized, and the... [DOC] [TLE] Animal models of tuberculosis for vaccine development - medIND [PAR] tuberculosis. Mice, guinea pigs and rabbits are animals most frequently used. ... 
delay in diagnosis of the disease, moderate relapse rates (5%) ... route as a 
result of few virulent tubercle bacilli get deposited in ... the low dose aerosol is 
being used in the pre-clinical .... because of its innate resistance to tuberculosis 
as well. [DOC] [TLE] CDC | TB | Interim Laboratory Biosafety Guidance for Extensively ... [PAR] Sep 1, 2012 ... Testing & Diagnosis .... Like other strains of M. tuberculosis, XDR tubercle bacilli 
may be ... Because of the low infective dose of M. tuberculosis (i.e., ID50 <10 ... if 
less resistant strains of M. tuberculosis can be used instead of XDR TB ... Animal 
studies using guinea pigs or mice can be conducted at ABSL-2. [DOC] [TLE] Diagnostic Standards and Classification of Tuberculosis [PAR] Sep 1, 1990 ... Collection of Specimens for Demonstration of Tubercle Bacilli ... Because the 
technology applicable to the diagnosis, treatment, and ..... and they may fail to 
produce progressive disease in guinea pigs, although not necessarily in humans. 
.... Given the low prevalence of drug-resistant M. tuberculosis in most... [DOC] [TLE] Virulence and Resistance to Superoxide, Low pH and ... - Microbiology [PAR] pared with regard to

Question: Guinea pigs are used to diagnose this disease because of their low resistance to the tubercle bacillus
Answer: tuberculosis