Datasets:

Javtor

/

biomedical-topic-categorization

like 0

long term outcom sar cov infect healthcar worker singl centr cohort studi long term symptom acut covid high debat nevertheless data long term symptom covid healthcar worker scarc

D000086382;D000086402

T047;T005;T067

long covid year hospitalis covid prospect bicentr cohort studi aim studi increas interest better understand long covid condit characteris long term sequela appear persist typic convalesc period coronavirus diseas covid herein describ long term outcom regard residu symptom psycholog distress hospitalis patient year covid method prospect cohort studi includ consecut adult patient hospitalis confirm covid two swiss tertiari care hospit march june primari endpoint evid long covid year discharg defin persist new symptom relat covid predefin list symptom secondari endpoint includ psycholog distress symptom post traumat stress disord ptsd result among patient includ studi symptom long covid year hospitalis particular fatigu concentr difficulti short breath post exert malais three predictor name durat hospitalis odd ratio confid interv ci p sever ill ci p self perceiv overal health status day hospitalis ci p associ long covid regard secondari endpoint experienc psycholog distress patient symptom ptsd conclus high proport covid patient report symptom long covid year hospitalis negat affect qualiti life import risk factor sever initi present covid long hospit stay

D000086382

T047;T067

manag transthyretin amyloidosi transthyretin amyloidosi attr amyloidosi diseas caus deposit transthyretin fibril organ tissu caus dysfunct clinic heterogen attr amyloidosi variabl present symptom earli diseas stage histor meant treatment delay diagnost tool therapi option attr amyloidosi mark improv recent year first swiss amyloidosi network san meet zurich switzerland januari aim defin consensus statement regard diagnost work treatment system amyloidosi tailor swiss healthcar system consortium clinician research swiss region univers select san committe repres sub specialti group involv care patient amyloidosi steer committe conduct literatur search analysi wrote critic synthesi elabor list statement evalu particip recommend improv outcom qualiti life patient attr amyloidosi global review guidelin plan everi year formal meet involv expert

D028227;D011788

T047;T078

heart rate profil heart rate variabl scuba dive aim present studi describ heart rate profil heart rate variabl pattern non select scuba diver differ age non experiment real world condit

D004242

T056

appar life threaten event brief resolv unexplain event manag children swiss tertiari care center appar life threaten event alt high stress situat caregiv common result present child emerg depart event usual brief resolv short period time entiti call brief resolv unexplain event brue updat recommend publish recent year manag brue includ risk stratif identifi lower risk subsequ event sever under disord aim studi describ epidemiolog alt brue hospit detail clinic practic manag popul tertiari care children hospit switzerland

D057768

T033

matter predictor qualiti life life satisfact among young breast cancer survivor younger breast cancer survivor face uniqu challeng research need better understand optim qualiti life qol satisfact life swl

D001943;D000073116

T191;T101;T201

short term effect random mind base intervent femal breast cancer survivor systemat review meta analysi patient breast cancer usual experi depress anxieti stress fatigu pain poor sleep qualiti low qualiti life cancer treatment studi use mind base stress reduct mbsr intervent reduc symptom howev result conflict

D001943;D000073116;D064866

T191;T041;T101;T201

financi toxic adolesc young adult cancer concept analysi cancer diagnosi adolesc young adult aya pose except challeng includ potenti greater financi toxic older survivor experi time career establish build financi asset cost patient increas past decad prospect aya long term surviv also increas better understand financi toxic present immedi longer term implic aya need

D000073116;D009369

T191;T101;T201

self manag strategi risk reduct subclin mild stage breast cancer relat lymphedema longitudin quasi experiment studi earli intervent self manag strategi potenti reduc risk progress breast cancer relat lymphedema bcrl

D001943;D008209;D000073278

T058;T191;T047;T046

dyadic cope coupl breast cancer china dyadic cope may play import role promot marit adjust coupl breast cancer howev studi explor dyadic cope predictor coupl breast cancer

D001943

T191

physic activ intervent colorect cancer survivor systemat review meta analysi random control trial physic activ pa shown improv total mortal colorect specif mortal risk howev colorect cancer crc survivor lower rate pa compar survivor type cancer

D015179;D011788

T191;T078

document symptom children newli diagnos cancer highlight need routin assess use self report symptom manag cornerston qualiti care potenti vast influenc patient experi support care need children howev well describ

D009369

T191

dimens dentogingiv tissu anterior maxilla cbct descript cross section studi characterist periodontium anterior teeth influenc outcom prognosi differ periodont implant restor procedur present studi cbct imag use determin alveolar bone thick lesser extent gingiv thick aim evalu use cbct measur dentogingiv complex anterior maxilla

D008437;D054894

T023;T060

analysi palat surfac anatomi maxillari central incisor complex behind simplic palat surfac maxillari anterior teeth conjunct incis edg repres mechan area great import later anterior guidanc therefor term restor dentistri crucial clinician detail knowledg palat surfac anatomi psa differ maxillari anterior teeth order reestablish definit correl form function esthet aim present studi analyz variat psa maxillari central incisor cis correl tooth form gender

D004955;D007180

T091;T023

partial anterior indirect restor case dentin exposur partial anterior ceram restor predict durabl treatment modal reestablish esthet also strength function bio emul minim invas dentistri adhes technolog key success restor partial restor indic teeth enough hard tissu bond veneer dentin exposur mani clinician still reli macromechan retent perform full crown prepar howev new research shown good surviv rate partial restor extens dentin exposur present articl describ two case step step protocol appli bond lamin veneer tooth dentin exposur

D003776;D003801

T122;T061

acceler fatigu resist endodont treat incisor without ferrul restor cadcam endocrown present studi aim investig resist failur mode broken endodont treat incisor without ferrul restor cadcam endocrown

D011176;D019553

T047;T074;T061

treatment plan teeth compromis clinic crown endodont reconstruct surgic strategi present articl describ treatment plan clinic strategi base flowchart develop facilit treatment teeth sever compromis clinic crown studi compris group patient present teeth need clinic crown reconstruct patient screen diagnos treat multidisciplinari approach accord flowchart structur subgroup teeth patient consid irrat treat composit risk evalu model appli anoth subgroup teeth patient requir periodont surgeri receiv minim invas crown lengthen micl procedur endodont treatment necessari teeth retreat teeth patient receiv full crown remain teeth receiv direct teeth indirect teeth reconstruct six teeth orthodont extrud surgeri year averag probe depth clinic attach level treat teeth mm mm respect bleed probe detect site side effect short term recurr detect treat site patient describ function esthet extrem satisfactori satisfactori satisfactori conclus accur screen base flowchart support clinic decis treat teeth micl replac teeth present clinic restor use micl high qualiti restor result healthi periodont dental condit treat teeth well patient satisfact year follow

D004955;D014070

T091;T023

determin color direct restor approach implement direct composit resin cr restor determin color challeng step reproduct tooth shade often sourc frustrat practition dental color complex accur reproduct requir good understand color practition also use appropri method achiev import rememb tooth color paramet one abl mimic crs purpos articl demystifi error attribut standard tool ie shade guid suggest number measur avoid error

D017797;D014070

T023;T061

evid coordin adjust osmolyt movement follow hyposmot swell rainbow trout red blood cell osmolyt involv volum regul hyposmot swollen fish cell well identifi howev coordin adjust flux obvious studi clear illustr aspect

D009997

T070

understand mechan retin displac follow rhegmatogen retin detach repair comput simul model retin displac common follow rhegmatogen retin detach rrd repair comput simul develop assess forc appli gas tamponad various size set pneumat retinopexi pnr versus par plana vitrectomi ppv

D012163

T047

combin metabol activ therapi amelior liver fat nonalcohol fatti liver diseas patient nonalcohol fatti liver diseas nafld refer excess fat accumul liver anim experi human kinet studi found administr combin metabol activ cmas promot oxid fat attenu result oxid stress activ mitochondria eventu remov excess fat liver test safeti efficaci cma nafld patient placebo control week studi found cma signific decreas hepat steatosi level aspart aminotransferas alanin aminotransferas uric acid creatinin wherea found differ variabl placebo group adjust weight loss integr clinic data plasma metabolom inflammatori proteom well oral gut metagenom data reveal under molecular mechan associ reduc hepat fat inflamm nafld patient identifi key player involv host microbiom interact conclus show cma use develop pharmacolog treatment strategi nafld patient

D065626

T047

metabol memori under minim residu diseas breast cancer tumor relaps treatment resist cell minim residu diseas mrd under breast cancer relat death yet molecular characterist defin malign larg remain elus integr multi omic data tractabl organoid system metabol model approach uncov metabol regulatori idiosyncrasi mrd find resist cell despit non prolif phenotyp absenc oncogen signal featur increas glycolysi activ certain urea cycl enzym reminisc tumor metabol distinct also evid mous model transcriptom data patient follow neo adjuv therapi identifi mark similar dna methyl profil tumor residu cell taken togeth data reveal metabol epigenet memori treatment resist cell demonstr memor elev glycolysi mrd crucial surviv target use small molecul inhibitor without impact normal cell metabol aberr mrd thus offer new therapeut opportun post treatment care prevent breast tumor recurr

D001943

T191

deliveri mir p pendant tetrahedron dna nanostructur use inject heparin lithium hydrogel challeng bone defect steroid associ osteonecrosi corticosteroid induc dickkopf dkk upregul wnt signal inhibit result bone metabol disord steroid associ osteonecrosi saon implant biomateri regul wnt pathway promis method repair challeng bone defect associ saon tetrahedr dna nanostructur tdns fabric gene carrier deliv mir p target dkk translat heparin lithium hydrogel li hep gel synthes act lithium mir tdns deliveri agent final repair effect challeng bone defect saon use mir tdnsli hep gel composit assess vivo result reveal mir tdns absorb bone mesenchym stem cell bmscs increas cell viabil reduc apoptosi moreov mir tdns promot alkalin phosphatas express calcium nodular deposit decreas lipid droplet express bmscs improv vascular endotheli growth factor secret vascular like structur format vitro mir tdnsli hep gel implant saon model intern bone defect osteonecrosi repair larg area new bone accompani neovascular reduc empti lacuna conclus mir tdnsli hep gel provid dual deliveri lithium mir tdns synergist upregul wnt signal pathway enhanc bone regener challeng bone defect potenti use saon repair

D035683;D049329;D010020

T047;T073;T123;T046;T114

factor correl run economi among elit middl long distanc runner run economi given submaxim run veloc defin oxygen consumpt per minut per kg bodi mass investig group male elit runner nation class addit km h measur maxim oxygen consumpt vo max anthropometr measur includ moment arm achill tendon l ach shank foot volum muscular fascicl length biomechan movement analysi treadmil run also conduct averag ml min kg km h maxim differ individu athlet km h mechan work rate signific correl vo measur l min run veloc howev relat work rate signific correl l ach signific correl km h impli short moment arm advantag regard neither foot volum shank volum signific correl relat muscl fascicl length soleus signific correl km h whole bodi stiff leg stiff signific correl l ach indic short moment arm coincid high stiff conclud short l ach correl probabl short l ach allow storag larger amount elast energi tendon influenc forc veloc relat toward lower contract veloc

D004734;D010101;D012420;D013647

T057;T056;T039;T061;T201;T040

development origin crocodylian skull tabl platyrostr face dorsoventr flatten skull typifi extant crocodylia perhap anatom featur general consid adapt semi aquat feed although evolutionari origin caniofaci flatten extens studi development origin yet explor understand skull tabl platyrostr snout develop quantifi embryon develop post hatch growth ontogeni crocodylian skull later view use geometr morphometr dataset n includ one extant genus major ecomorph includ extrem slender snout gaviali tomistoma analysi reveal embryon develop flatten skull remark similar across ecomorph includ presenc conserv initi embryon skull shape similar prior analysi dorsal snout shape although differ posthatch ontogeni recov among ecomorph embryon pattern distinct reveal import shift development rate near hatch particular flatten skull tabl achiev end embryon develop chang hatch rotat skull roof facial bone develop critic stereotyp flat crocodylian skull result suggest select hatchl perform constraint embryon skull shape may import pattern development conserv appear aspect cranial flat among jurass stem crocodylian suggest key aspect cranial development pattern may conserv million year

D000489

T014

feed feed transport potenti rout porcin epidem diarrhoea outbreak sow breed herd mexico porcin epidem diarrhoea virus pedv infect pig age caus vomit diarrhoea pedv transmit via oral faecal rout low dose enough infect suscept pig result signific product loss short communic aim describ introduct pedv sow farrow wean farm locat northwest mexico follow onset clinic sign outbreak investig conduct determin probabl rout introduct base data collect interview construct timelin event detect pedv rna feed sampl sampl collect various surfac feed transport vehicl conclud probabl rout pedv incurs breed herd contamin feed contamin feed transport vehicl paper describ feed feed transport could serv potenti rout pedv infect farm highlight import establish biosecur program mitig risk

D018352;D005506;D053485;D013553

T047;T005;T068;T067

probabilist co occurr assess suit list speci section endang speci act requir us environment protect agenc us epa consult servic us fish wildlif servic nation marin fisheri servic potenti pesticid impact feder list speci consult complic larg number pesticid product list speci well lack consensus best practic conduct co occurr analys previous work demonstr probabilist estim speci rang pesticid use pattern improv analys demonstr estim made suit sympatr list speci focus two watersh one iowa mississippi obtain distribut record speci terrestri aquat list plant anim occur therein use maximum entropi model bioclimat topograph hydrograph land cover variabl predict speci rang high spatial resolut construct probabilist spatial model use area two pesticid base us depart agricultur cropland data layer reduc classif error incorpor inform relationship individu pixel neighbor use object base imag analysi combin speci distribut crop footprint model deriv overal probabl co occurr list speci pesticid use aquat speci also integr estim downstream residu transport report separ speci use area co occurr estim also combin model co occurr probabl across speci within watersh produc overal metric potenti pesticid exposur risk list speci watersh level propos consult process us epa servic base batch estim probabilist co occurr multipl list speci region scale integr environ assess manag setac

D010575

T131

nonlinear respons ecosystem carbon flux nitrogen deposit old growth boreal forest nitrogen n deposit known increas carbon c sequestr n limit boreal forest howev long term effect n deposit ecosystem carbon flux rare investig old growth boreal forest show decad long experiment n addit signific stimul net primari product npp effect decreas increas n load effect soil heterotroph respir rh shift stimul low level n addit inhibit higher level n addit consequ low level n addit result neutral effect net ecosystem product nep due compar stimul effect npp rh nep increas high level n addit moreov found nonlinear tempor respons npp rh nep low level n addit find impli actual n deposit boreal forest like exert minor contribut soil c storag

D017753;D009584

T070;T082;T196;T123

intra articular steroid inject larg joint arthriti survey current practic intra articular corticosteroid inject wide use manag modal mild larg joint osteoarthr oa contrast littl guidanc consensus use steroid moder sever diseas aim studi explor current practic surgeon relat use therapeut intra articular steroid inject patient await larg joint arthroplasti oa

D001168;D020370

T047

decis make regard oral nutrit supplement nurs home resid advanc dementia cross section pilot studi surrog decis make regard oral nutrit supplement on nurs home resid advanc dementia complex process cross section studi assess whether dutch dietitian elder care physician physician surrog decis maker sdms differ factor regard import consid on also investig differ opinion regard whether on life prolong measur

D003704;D044342

T048;T047

prepregn weight chang effect subsequ pregnanc health outcom systemat review meta analysi intern guidelin recommend women overweight obes bodi mass index bmi aim reduc bodi weight prior concept minim risk advers perinat outcom recent systemat review demonstr interpregn weight gain increas women risk develop advers pregnanc outcom subsequ pregnanc interpregn weight chang studi exclud nullipar women systemat review meta analysi conduct follow moos guidelin summar evid impact preconcept interpregn weight chang perinat outcom women regardless pariti sixti one studi met inclus criteria review report differ outcom identifi signific increas risk gestat diabet ci hypertens disord ci preeclampsia ci larg gestat age ci preconcept interpregn weight gain interpregn weight loss signific associ increas risk small gestat age ci preterm birth ci find illustr need effect preconcept interpregn weight manag support improv pregnanc outcom subsequ pregnanc

D011248;D047928

T046

probiot supplement healthi pre school age children preval predictor probiot shown prevent treat number paediatr health problem howev much known probiot use communiti studi aim describ preval main predictor probiot supplement among healthi pre school age children

D019936

T007

function express py receptor mous ovarian surfac epithelium ose ovarian surfac epithelium ose cell monolay surround ovari involv regul ovulatori process genesi ovarian carcinoma howev intercellular messeng regul signal event like prolifer ose complet describ purin emerg novel intercellular messeng ovari express purinerg receptor report differ cell type present work describ function express py receptor pyr purinerg receptor wide associ cell prolifer ose express pyr immunofluoresc rt pcr function ca record demonstr primari cultur ose function express pyr also exhibit situ record intracellular ca releas detect erk phosphoryl inject select agonist ovarian bursa furthermor pyr activ utp situ induc cell prolifer h wherea continu stimul pyr complet estrous cycl signific modifi size distribut follicular popul first evid function express purinerg pyr ose open new perspect role play purin ovarian physiolog

D010053

T023

evalu pulmonari hypertens use flow mri cardiac magnet reson imag mri becom altern right heart catheter rhc evalu pulmonari hypertens ph need exist evalu cardiac mri abil character ph

D006976;D000081029

T047;T046

util clingen gene diseas valid dosag sensit curat inform variant classif understand whether enough evid implic gene role given diseas well mechan variant gene might caus diseas essenti determin clinic relev nation institut health fund clinic genom resourc clingen develop evalu framework assess strength evid support relationship gene diseas gene diseas valid whether loss haploinsuffici gain triplosensit individu gene genom region mechan diseas dosag sensit clingen activ appli framework across multipl diseas domain make inform public avail via websit https wwwclinicalgenomeorg use multipl applic includ clinic variant classif describ result curat process util inform appropri applic pathogen criteria sequenc copi number variant well guid test develop inform genom filter pipelin

D014644;D015894

T070;T028

happen diet qualiti peopl newli diagnos type diabet case seri studi diet qualiti play import role prevent diabet relat complic peopl type diabet mellitus tdm howev evid scarc diet qualiti typic chang time diagnosi present studi aim describ diet qualiti individu newli diagnos tdm chang month period identifi factor associ diet qualiti chang

D003924;D000073601

T047;T061

analysi patient specif nf variant lead function insight ras signal impact person medicin creat panel nf variant complementari dnas cdnas repres missens variant mani clinic relev phenotyp frame delet splice variant nonsens variant determin function consequ variant assess abil produc matur neurofibromin restor ras signal activ nf null cell cdnas demonstr variant specif differ neurofibromin protein level suggest variant lead neurofibromatosi type nf gene protein instabl enhanc degrad express high level variant protein still abl repress ras activ indic nf phenotyp may due low protein abund contrast variant protein incap repress ras activ indic function engag ras stimul gtpase activ observ effect protein abund ras activ mutual exclus assay allow us categor variant function effect may help classifi variant unknown signific may futur implic direct therapeut

D009456;D025542;D057285

T191;T047;T116;T123;T091;T061

effect horticultur therapi physic function psycholog health outcom older adult systemat review meta analysi systemat determin effect horticultur therapi ht physic function psycholog health older peopl

D058611;D009369

T191;T061

infrar thermomet infant devic hot babi mayb risk serious ill febril infant day old high fever often warrant aggress manag infrar thermomet unreli young infant despit ubiqu aim describ frequenc infrar thermomet usag ii progress document fever emerg depart ed iii rate serious ill mening urinari tract infect bacteremia

D001831;D013821

T032;T074

peripher pulmonari lesion confirm pulmonari arteri embol follow studi b mode ultrasound perfus pattern use contrast enhanc ultrasound ceus retrospect studi aim describ b mode lung ultrasound b lus contrast enhanc ultrasound ceus follow pattern peripher pulmonari lesion ppls patient confirm pulmonari embol pe

D006976;D011655;D054060

T047;T046

relationship simul gadolinium base contrast agent inject profil achiev resolut metric contrast enhanc magnet reson angiographi contrast bolus variat contrast enhanc magnet reson angiographi ce mra acquisit may lead vessel blur

D003287;D018810

T130;T060

covid children ii pathogenesi diseas spectrum manag global disrupt covid pandem impact life everi child either direct indirect review explor pathophysiolog immun respons clinic present treatment covid children summaris date data includ recent develop regard variant concern acut infect sar cov general mild children whilst post infecti manifest includ paediatr inflammatori multisystem syndrom tempor associ sar cov pim ts long covid children complex given research covid focus adult cohort clinic manifest treatment avail impact differ mark children research specif examin covid children need prioritis

D000086382

T047;T067

screen protocol preval venous thromboembol diseas hospit patient covid sar cov diseas covid induc endotheli damag sustain hypoxia facilit immobil factor hypercoagul

D000086382;D011655;D054556;D020246

T046;T047;T067

downregul tripartit motif protein attenu cardiomyocyt apoptosi ischemiareperfus injuri via dusp jnk current prevent ischem diseas myocardi infarct associ ischemiareperfus ir injuri remain challeng thus studi design explor effect tripartit motif protein trim cardiomyocyt ir injuri under mechan cardiomyocyt ac use establish ir injuri cell model trim downregul ir cell cell prolifer h apoptosi h well relat molecular chang oxid stress relat pathway detect treatment trim overexpress sp dusp overexpress cell prolifer apoptosi relat gene detect per find determin trim high express cardiomyocyt ac ir injuri downregul trim determin signific reduc ir induc prolifer suppress apoptosi besid ir activ c jun n termin kinas jnk signal cleav caspas bax express signific inhibit trim downregul addit overexpress trim signific promot apoptosi ac cell jnk inhibit dusp overexpress potent counteract induct trim overexpress ac cell suggest downregul trim attenu apoptosi ac cell ir injuri probabl dusp jnk pathway

D017209

T043;T116;T123

sting inhibit acceler bone heal process enhanc type h vessel format stimul interferon gene sting one critic factor innat immun indic close relat angiogenesi studi examin sting role angiogenesi format type h vessel specif subtyp bone vessel regul bone heal differ concentr cgamp h c appli activ inhibit sting respect human umbil vein endotheli cell use examin effect sting angiogenesi vitro cell viabil cell migrat quantit real time polymeras chain reaction perform also metatars experi appli ex vivo proof bone fractur defect mice model use examin effect sting vivo bone heal process evalu radiographi week ct th day surgeri format type h vessel cd hi emcn hi endotheli cell osteogenesi ocn posit cell assess use cryosect paraffin section sting activ inhibit angiogenesi vitro ex vivo slow bone heal process vivo histolog analysi show increas callus format fewer type h vessel almost callus miner sting activ group compar control group contrast h hssting inhibitor promot angiogenesi low dose moreov inhibit mmsting c enhanc type h vessel format impli osteogenesi promot bone heal higher bone volum densiti ocn posit cell data suggest sting inhibit acceler bone heal process enhanc type h vessel format

D017102;D018919

T039;T042

btt amelior hepat fibrosi non alcohol fatti liver anim model btt hexyl trimethylhydroquinon hydroquinon deriv potent anti oxid safe toler phase clinic trial studi examin anti fibrot effect btt mous model non alcohol fatti liver diseas nafld along under mechan vivo efficaci btt evalu three kind nafld model methioninecholin defici diet mcd high fat diet hf western diet wd metabolom transcriptom profil analysi liver tissu conduct vitro anti fibrot effect btt assess human hepat stellat cell hscs primari mous hscs btt improv nafld activ score three kind nafld anim model mcd hf wd btt also decreas level hepat pro collagen collagen fiber deposit liver tissu metabolom transcriptom analysi reveal btt decreas lipid metabolit increas antioxid nafld mice hepg cell btt enhanc nrf report activ dose depend manner increas level antioxid gene express btt show inhibit hscs activ migrat gene express profil protein express show btt increas nrf activ well decreas pik akt pathway activ hscs btt attenu amelior steatohepat hepat fibrosi

D006873

T121;T109

call develop point care ultrasound train recommend obstetr gynecolog resid point care ultrasound pocus skillset taught throughout train level medic school fellowship given broad util assist bedsid procedur triag clinic present expedit workup reflect train curricula emerg medicin intern medicin general surgeri resid howev skillset formal taught requir obstetr gynecolog resid present opinion skillset curricula develop obstetr gynecolog traine given exposur patient similar clinic present clinic manag would aid pocus

D006176;D007396;D009774

T091;T065;T097

hdac contribut human resist mycobacterium tuberculosi infect via mediat innat immun respons tuberculosi tb caus mycobacterium tuberculosi mtb remain major caus morbid mortal worldwid increas line evid indic certain individu term resist natur resist tb infect resist phenotyp link host effici innat immun respons under mechan key immun factor remain unclear find upon mtb infect monocyt deriv macrophag mdms tb resist exhibit distinct higher product tnf il il higher ratio bacteria acid vacuol lower intracellular bacteri load compar healthi control individu latent tb infect tb patient enhanc anti mtb immun capac macrophag resist larg depend histon deacetylas hdac whose express specif maintain mdms tb resist mtb infect furthermor demonstr hdac requir acidif mtb contain phagosom macrophag thus control intracellular surviv mtb taken togeth find unravel indispens role hdac human innat resist mtb infect suggest hdac may serv marker individu tb risk well novel host direct anti tb therapeut target

D060467;D007113

T040;T032

osteoporosi rather sarcopenia predomin musculoskelet diseas rural south african communiti human immunodefici virus preval high cross section studi rollout antiretrovir therapi global increas life expect across southern africa million peopl live human immunodefici virus hiv aim determin preval age relat osteoporosi sarcopenia investig associ hiv bone miner densiti bmd muscl strength lean mass gait speed cross section communiti base studi individu age year rural south africa collect demograph clinic data includ hiv status grip strength gait speed bodi composit bmd sarcopenia defin european work group sarcopenia older peopl ewgsop guidelin osteoporosi bmd score age year mean standard deviat sd age black south african particip year femal men women hiv overal take anti retrovir therapi femor neck score seen four men women age year common women without hiv versus p although particip confirm sarcopenia probabl sarcopenia affect men women versus p although appendicular lean mass alm height index lower men women hiv differ grip strength gait speed probabl sarcopenia hiv status older age femal sex lower almheight index slower gait speed hiv infect independ associ lower femor neck bmd conclus osteoporosi rather sarcopenia common musculoskelet diseas age rural south africa older women hiv may experi greater bone loss women without hiv find rais concern futur fractur risk southern africa hiv clinic consid routin bone health assess particular age women author journal bone miner research publish wiley period llc behalf american societi bone miner research asbmr

D015658;D010024;D055948

T047

total nucleat cell dose graft better prognost factor surviv pediatr patient transplant bone marrow compar cd cd total mononuclear cell count studi investig impact graft composit transplant relat outcom focus effect cd cell dose report equivoc result aim studi investig impact dose total nucleat cell tncs total mononuclear cell tmcs cd cd cell outcom children receiv allogen hematopoiet stem cell transplant hsct

D018952;D016026;D017252;D018380

T129;T116;T061

copeptin assay children differenti diagnosi polyuria polydipsia syndrom refer level hospit children polyuria polydipsia syndrom pps common present children differenti diagnosi rest burdensom water depriv test aim studi determin copeptin threshold distinguish patient central diabet insipidus primari polydipsia estim normal rang copeptin concentr children

D002673;D011141

T184;T101

hpv posit status independ factor associ sinonas invert papilloma recurr present studi aim evalu human papillomavirus hpv occurr sinonas invert papilloma snip assess factor associ hpv posit snip recurr

D052685;D009669;D018308;D030361;D010255

T191;T047;T005

harmon subharmon imag character breast lesion multi center clinic trial breast cancer frequent type cancer among women multi center studi assess abil contrast enhanc ultrasound character suspici breast lesion use clinic assess quantit paramet

D001943;D003287

T130;T191

core cyberaggress group base explan studi prototyp aggressor test group level factor predict social media user activ particip cyberaggress particip expos fictiti convers either prototyp versus non prototyp user post aggress comment repli provoc comment line self categor theori hypothes bystand particip would post aggress comment rate aggress accept greater extent prototyp non prototyp condit furthermor predict perceiv normat aggress would mediat effect prototyp result support predict show prototyp member affect extent collect aggress behavior onlin interact approv enact find highlight import group level factor studi cyberaggress provid import inform understand psycholog underpin collect form onlin aggress

D000374;D061108

T170;T055

meta analyt review adapt function fetal alcohol spectrum disord effect iq execut function age fetal alcohol spectrum disord fasd high preval development disabl associ prenat alcohol exposur addit vari strength uniqu talent peopl fasd experi signific challeng includ adapt function adapt function refer skill relat everyday life communic practic skill social skill current review aim understand adapt function fasd compar alcohol nonexpos individu attent deficit hyperact disord adhd addit investig relationship may chang base iq execut function age

D056344;D007361

T060;T041

antioxid activ sulfat codonopsi polysaccharid acut oxid stress studi aim explor protect effect sulfat codonopsi polysaccharid scp acut oxid stress scp modifi chlorosulfon acid pyridin method codonopsi polysaccharid cp sulfat content determin ultrason acid barium chromat spectrophotometri analysi fourier transform infrar spectroscopi ft ir appear absorpt peak scp cm relat c vitro test antioxid activ cp scp induc h raw cell result indic scp cp could signific enhanc activ superoxid dismutas sod glutathion peroxidas gdh px catalas cat nitric oxid decreas level malondialdehyd mda reactiv oxygen speci ros induc nitric oxid synthas ino secret raw cell compar model group p flow cytometri result also reveal scp cp could mark inhibit apoptosi macrophag induc acut oxid stress vivo test ethanol use induc mice acut oxid stress result indic blood biochem paramet mice restor normal level follow administr scp cp alanin aminotransferas alt aspart transaminas ast total protein tp albumin alb glucos glu creatinin urea signific differ compar model group p quantit real time pcr analysi reveal scp cp could promot express keap nrf summari scp cp protect effect acut oxid stress practic applic oxid stress kind stress injuri caus varieti diseas acceler physic age codonopsi mani activ compon among codonopsi polysaccharid antioxid effect recent studi found codonopsi polysaccharid could modifi sulfat molecul obtain higher antioxid activ modifi codonopsi polysaccharid could signific promot product antioxid enzym sod cat gdh px reduc content oxid stress mark ros mda moreov antioxid mechan may relat keap nrf signal pathway therefor scp effect antioxid could use potenti health food antioxid anti age effect

D000975;D029745

T044;T121;T002;T123;T039

immun cell infiltr prognosi local prostat cancer multipl line evid indic quantif immun cell infiltr primari prostat cancer predict outcom radic prostatectomi includ biochem recurr metastasi death prostat cancer recent issu journal patholog andersen et al explor predict valu cancer tissu infiltr seven immun cell type mast cell macrophag macrophag b cell helper cell cytotox cell regulatori cell associ biochem recurr radic prostatectomi addit report potenti associ cancer infiltr regulatori cell macrophag biochem recurr studi also highlight use multiplex digit patholog analys assess advers predictor prostat cancer outcom patholog societi great britain ireland publish john wiley son ltd

D011471;D059016

T070;T191

liver biopsi real world report expert concord correl pragmat clinic diagnosi patient non alcohol steatohepat nash fibrosi stage compris target popul pharmacotherapi liver biopsi refer standard identifi popul requir complet accur assess steatohepat fibrosi aim investig complet real world nash relat patholog report assess concord site pathologist central expert interpret histolog element nash determin concord biopsi diagnos nash pragmat clinic definit nash

D003924;D065626

T047

chang physicochem properti antioxid organ key volatil compound associ flavor peach prunus cerasus l batsch vinegar ferment process peach delici food prefer consum wide use manufactur peach juic peach juic concentr peach jam dri fruit pure etc altern peach use product vinegar studi peach vinegar produc altern industri product produc peach studi determin tpc content orac valu peach vinegar higher peach juic peach wine addit major contributor compound aroma profil sampl decalacton linalool geraniol compound peach juic ethanol decalacton phenylacet acid acet acid phenylethanol ethyl decano linalool decano acid peach wine decalacton phenylacet acid acet acid phenethyl acet isovaler acid peach vinegar thought result studi pave way widespread product vinegar peach posit effect health rich volatil aroma compon high potenti prefer furthermor studi first detail studi far peach vinegar practic applic studi aim produc vinegar new altern foodstuff product peach fruit normal process fresh dri fruit fruit juic pure can fruit industri altern idea creat use peach fruit short shelf life studi antioxid capac organ compound volatil compound associ aroma profil peach vinegar ferment process determin moreov chang compound monitor ferment process result studi guid usabl peach fruit raw materi product peach vinegar potenti posit effect health rich volatil aroma compon high potenti prefer furthermor studi first detail studi peach vinegar

D000068220;D000068239

T129;T121;T002;T168

obes due melanocortin receptor mcr defici associ delay gastric empti peopl sever obes due melanocortin receptor mcr defici experi hyperphagia impair full meal satieti meal induc satieti influenc hormon peptid yy pyy releas enteroendocrin cell upon nutrient deliveri small intestin

D018589;D044105

T192;T116;T047

therapi inflammatori bowel diseas pose addit risk advers outcom sar cov infect ig ibd studi older age comorbid main risk factor advers covid outcom patient inflammatori bowel diseas ibd impact ibd medic still investig

D000086382;D003093;D003424;D015212

T047;T067

predictor postop nausea vomit endoscop skull base surgeri object studi evalu impact patient surgic factor includ approach reconstruct type postop nausea vomit episod follow endoscop skull base surgeri

D000932;D020250

T039;T121;T184

perceiv fair unfair world system justif mental health girl detent facil psychologist help profess long accept idea cognit implic mental health wellb communiti psychologist establish import context system etiolog mental health problem paper argu disciplin priorit social justic communiti psycholog consid associ cognit structur system inequ individu mental health particular margin popul one illustr argument complex ask degre mental health concurr associ adolesc belief societ fair ie system justifi belief attend gender differ find inform sampl adolesc resid detent facil girl blackcaribbean multiraci hispaniclatin lgbtq youth repres understudi group research literatur address fair belief influenc well result suggest boy like endors societ fair compar girl belief unrel mental health howev found signific gender moder girl perceiv societi fair report lower level intern extern mental health problem discuss implic theori research intervent

D008603;D012935

T080;T041;T078

anti fatigu effect ferment soybean protein peptid mice bioactiv protein hydrolys peptid believ help counteract amelior physic fatigu ferment soybean protein peptid fspps prepar proteas hydrolysi microbi ferment present studi aim evalu anti fatigu properti fspps

D000074421;D030262

T116;T121;T168;T123

intervent outsid school hour childcar set promot physic activ amongst schoolchildren age year insuffici physic activ one four primari risk factor non communic diseas stroke heart diseas type diabet cancer chronic lung diseas one five children age year physic activ recommend health benefit outsid school hour period contribut around children daili physic activ present key opportun children increas physic activ test effect intervent outsid school hour childcar set requir assess potenti increas physic activ reduc diseas burden

D002654;D003924

T052;T047;T056

structur human replisom show organis interact dna replic machin human replisom elabor arrang molecular machin respons accur chromosom replic heart cdc mcm gin cmg helicas addit unwind parent dna duplex arrang mani protein includ lead strand polymeras pol togeth timeless tipin claspin key vari role maintain smooth replisom progress protein coordin human replisom poor understood determin cryo em structur human replisom compris cmg pol timeless tipin claspin bound replic fork dna structur permit detail understand timeless tipin pol engag cmg reveal claspin bind multipl replisom compon identifi posit pol catalyt domain furthermor intric network contact contribut mcm subunit timeless tipin replic fork dna suggest mechan strand separ

D004261

T045

effici prefer altern activ schedul thin function communic train function communic train effect treatment decreas social reinforc destruct behavior carr durand clinician frequent use multipl schedul thin reinforc schedul hanley et al individu often taught wait function reinforc without altern program stimuli howev concurr avail item activ often access natur environ studi taught particip function communic respons access function reinforc implement multipl schedul schedul thin compar control condit noth avail interv separ condit itemsact moder prefer tangibl item attent demand nonconting avail interv reach termin schedul one condit therapist assess particip prefer across condit particip termin schedul reach altern item activ particip prefer correspond effici schedul thin condit therapist also indic prefer altern itemsact

D001288;D001521

T061;T041

model bioaffin base target deliveri antimicrobi escherichia coli biofilm use yeast microparticl part model develop numer simul biofilm potenti reservoir pathogen microb lead signific challeng food safeti ecosystem human health various micro nanoparticl experiment evalu improv biofilm inactiv target deliveri antimicrobi howev role transport process reaction kinet deliveri system well understood studi mechanist model approach develop understand target deliveri chlorin escherichia coli biofilm use novel bioaffin base yeast microparticl biofilm inactiv deliveri system numer simul combin reaction kinet transport phenomena simul result demonstr target deliveri system achiev log reduct within min equival level convent free chlorin achiev log reduct treatment time numer result match experiment observ previous studi studi illustr potenti mechanist model approach improv fundament understand guid design target inactiv biofilm use biobas particl

D000890;D004926;D008954

T007;T121;T075

intervent target women encourag uptak cervic screen updat cochran review publish issu worldwid cervic cancer fourth commonest cancer affect women high risk human papillomavirus hpv infect causat case risk factor includ smoke multipl sexual partner presenc sexual transmit diseas immunosuppress primari prevent strategi cervic cancer focus reduc hpv infect via vaccin data suggest potenti prevent near case vaccin prior hpv exposur howev countri afford vaccin programm worri uptak mani countri extrem poor secondari prevent screen programm remain critic reduc cervic cancer especi unvaccin women vaccin later adolesc includ screen detect pre cancer cell well high risk hpv uk sinc introduct cervic screen programm associ mortal rate cervic cancer fallen howev worldwid great variat countri coverag uptak screen countri nation screen programm avail wherea other screen provid opportunist basi addit differ within countri uptak depend ethnic origin age educ socioeconom status thus understand incorpor factor screen programm increas uptak screen togeth vaccin lead cervic cancer becom rare diseas

D002583

T191

intraperiton local anaesthet instil versus intraperiton local anaesthet instil laparoscop cholecystectomi pain one import reason delay discharg laparoscop cholecystectomi use intraperiton local anaesthet laparoscop cholecystectomi may way reduc pain previous version cochran review found low certainti evid benefit harm intervent

D000779;D017081

T061;T121;T109

model bioaffin base target deliveri antimicrobi escherichia coli biofilm use yeast microparticl part ii paramet evalu valid design bioaffin base target deliveri system biofilm inactiv may requir comprehens understand physicochem biochem properti biobas antimicrobi particl interact biofilm studi escherichia coli biofilm inactiv chlorin charg yeast microparticl numer simul role chemic stabil bind affin control releas target deliveri system assess use numer simul simul result experiment valid use two differ type yeast microparticl result studi illustr chorin stabil achiev yeast microparticl key factor improv biofilm inactiv organ rich environ addit log reduct min compar free chlorin treatment moreov bind affin yeast microparticl e coli biofilm anoth key factor enhanc inactiv biofilm fold increas bind rate result fold faster inactiv overal mechanist model framework develop studi could guid design develop biobas particl target inactiv biofilm

D000890;D004926;D008956

T007;T170;T121

felt deficit time children individu contextu factor across european countri sizeabl portion parent say lack time children import social problem given time strain link parent well extend perspect demand reward parent beyond individu level provid contextu level window onto mother father time strain base data european qualiti life survey n analyz whether parent feel spend enough time care children use multilevel model first observ countri context matter percept time moder weak relat hour children across countri especi father suggest vari social expect across europ second multivari analys examin micro macro level factor show individu level feel littl time children frequent among father work hour even control estim week hour spent care children countri level parent time strain higher countri employe less time place flexibl typic central eastern well southern europ gender norm matter well extend contextu perspect argu gender work famili regim color felt time strain promis futur research direct

D016487;D011788

T054;T078

sulfur driven autotroph denitrif nitric oxid effici nitrous oxid recoveri nitrous oxid n previous deem potent greenhous gas actual untap energi sourc accumul microbi denitrif nitric oxid compar organ electron donor requir heterotroph denitrif element sulfur promis electron donor altern due cheap cost low biomass yield sulfur driven autotroph denitrif howev effort made test n recoveri sulfur driven denitrif far therefor studi batch continu experi carri investig remov perform n recoveri potenti via sulfur driven base denitrif various fe ii edta concentr effici energi recoveri achiev convert n various concentr n recoveri fe ii edta could enhanc low bioavail sulfur acid environ caus sulfur oxid reductas n reductas n inhibit distinct relat low level lead effici n accumul suppress irrevers level beyond mm continu experi result indic regul relat low level would benefit system stabil remov capac long term system oper continu oper sulfur driven fe ii edta base denitrif reduc overal microbi divers enrich sever key microbi communiti thauera thermomona arenimona abl carri sulfur driven autotroph denitrif becam domin organ relat abund increas collect

D064307;D009569;D009609

T121;T123;T001;T032;T028;T197

strategi improv smoke cessat rate primari care primari care import set treat tobacco addict howev rate provid address smoke cessat success support vari strategi implement improv increas deliveri smoke cessat support eg provid train increas amount breadth support given peopl smoke eg addit counsel tailor print materi

D016540

T055

whole cell pertussi vaccin earli infanc prevent allergi children atop diseas common chronic condit childhood appar rise food anaphylaxi young children past three decad particular concern owe lack proven prevent strategi time introduct peanut egg due report vitro differ immun respons young infant prime whole cell pertussi wp versus acellular pertussi ap vaccin systemat apprais synthesis evid safeti potenti allergi prevent benefit wp inform recommend futur practic research

D004485;D006969;D014917

T047;T046

framework social determin health delirium tailor older adult delirium debilit medic condit disproportion affect hospit older adult associ advers health outcom increas mortal high medic cost effort understand delirium risk hospit older adult focus examin medic comorbid pre exist cognit deficit clinic demograph factor present period proxim hospit contribut social determin health sdoh includ social circumst environment characterist earli life exposur refer social exposom delirium risk poor understood increas knowledg influenc sdoh offer comprehens understand factor may increas vulner delirium poor outcom clinic effort guid develop implement holist prevent strategi improv clinic outcom propos sdoh framework delirium adapt older adult provid definit descript rational domain variabl propos model

D064890

T033;T067

minim invas treatment lower urinari tract symptom men benign prostat hyperplasia network meta analysi varieti minim invas treatment avail altern transurethr resect prostat turp manag lower urinari tract symptom lut men benign prostat hyperplasia bph howev unclear treatment provid better result

D059411;D011470;D020728

T191;T047;T184;T061

behaviour cognit behaviour therapi obsess compuls disord ocd individu autism spectrum disord asd autist spectrum disord asd increas recognis neurodevelopment condit neurolog base condit interfer acquisit retent applic specif skill asd characteris challeng socialis communic stereotyp repetit behaviour stereotyp behaviour one repeat seem use function asd often co occur mental health disord includ obsess compuls disord ocd peopl asd may show certain cognit differ ie differ way think influenc respons therapi thus need evid base guidelin treat mental health issu group ocd common condit characteris repeat obsession thought compuls act occur greater frequenc person asd general popul genet anatom neurobiolog psycholog factor propos explain co occurr howev care taken distinguish stereotyp repetit behaviour characterist asd obsess compuls act ocd cognit behaviour therapi cbt recommend treatment ocd studi suggest treatment may less effect ocd co occur asd henc modif cbt treatment may help treat ocd co occur asd optimis outcom

D000067877;D015928;D009771

T048;T061

telehealth intervent remot monitor consult peopl chronic obstruct pulmonari diseas copd chronic obstruct pulmonari diseas copd includ bronchiti emphysema chronic condit caus short breath cough exacerb lead poor health outcom face face visit health profession hinder sever copd frailti peopl live distanc healthcar provid limit access servic telehealth technolog aim provid health care remot monitor consult could help improv health outcom peopl copd

D029424;D017216

T058;T047

teacher use fear appeal associ student teacher mental health fear appeal discours common use teacher motiv student especi academ outcom paramount fear appeal associ better wors academ perform student recipi evid fear appeal detriment student anxious lower self efficaci littl known factor drive teacher use fear appeal beyond desir increas motiv excel

D008603;D013334

T098;T041;T081

calcium supplement prevent primari hypertens hypertens major public health problem increas risk cardiovascular kidney diseas sever studi shown invers associ calcium intak blood pressur small reduct blood pressur shown produc rapid reduct vascular diseas risk even individu normal blood pressur rang first updat review evalu effect calcium supplement normotens individu prevent health measur

D002118;D006973

T047;T121;T196;T123

understand ideat fluenci surviv process student generat idea import inter individu varianc exist quantiti qualiti idea abl produc eg perfectionist high creativ idea mass produc produc lot uncreat idea educ psycholog research creativ relat quantiti qualiti idea well understood limit progress area

D003405;D010551

T041;T078

role microglia neural remodel retin degener retina remodel consequ mani retin degen diseas character progress photoreceptor death retina remodel involv seri complex patholog process consist photoreceptor degener death well retin cell reprogram rewir rewir alter retin neural circuit center synapt connect lead widespread death retin cell retin remodel especi inner retin remodel major factor limit effect various treatment strategi includ cell therapi thus import elucid mechan involv retin remodel retin degener microglia domin immun cell retina microglia monitor retin microenviron activ follow retin injuri degener power phagocytosi capabl play critic role synapt prune central neural system develop analog microglia found particip clearanc synapt element complement depend manner classic retin pigmentosa rp model royal colleg surgeon rcs rat retard format ectop neuritogenesi deterior visual function retin degener sinc previous research microglia rare concentr synapt remodel retin degener summar microgli mechan involv retin remodel necessari order design compound target microglia retin remodel might promis therapeut strategi treat retin degener

D012162;D012174

T047;T046

chang brain dopamin extracellular concentr ethanol administr rat microdialysi studi purpos review evalu microdialysi studi alter dopaminerg system evalu differ intox state anim show prefer alcohol well alcohol withdraw

D000437;D013375

T048;T184

proteolyt activ bacillus thuringiensi cryaa toxin red palm weevil coleoptera curculionida red palm weevil rpw rhynchophorus ferrugineus oliv import pest palm caus signific damag bore feed within palm stem tissu studi proteolyt process cryaa rpw understand mechan cri toxic bioassay show cryaa toxin weak toxic rpw proteolyt activ assay indic cryaa protein digest smaller fragment kda activ fragment differ condit particular higher mass ratio gut proteas cryaa protein respect c h solut ph cryaa protoxin digest gut proteas weevil larva moreov zymogram analysi gut proteas reveal rpw larva harbor intestin digest enzym main compos serin proteas studi describ proteolyt activ process cryaa midgut rpw larva

D000083722;D001517;D004731;D006460;D048889

T116;T109;T123;T131;T204

reduct oxid stress suppress poli gr mediat toxic zebrafish embryo hexanucleotid gc repeat expans corf gene common pathogen caus frontotempor dementia ftd amyotroph later sclerosi al repeat expans translat dipeptid repeat protein dprs distribut poli gr dpr correl neurodegener postmortem cftdal brain assess poli gr toxic zebrafish embryo use annexin base fluoresc transgen line seca allow detect quantif apoptosi vivo microinject rna encod poli gr fertil oocyt evok apoptosi brain abnorm motor neuron morpholog trunk day postfertil embryo poli gr specif detect protein homogen inject zebrafish frontal cortex cftdal case poli gr express elev mitosox level zebrafish embryo indic oxid stress inhibit reactiv oxygen speci use trolox show full suppress poli gr toxic studi indic poli gr exert toxic via oxid stress zebrafish model use find suppressor poli gr toxic identifi molecular target under neurodegener observ cftdal

D000690;D057180

T048;T047

tattoo artist dental worker similar musculoskelet pain pattern tattoo artist understudi popul regard musculoskelet msk pain

D009140;D059352;D009784;D013653

T058;T033;T047

shift rotat scheme sleepi sleep qualiti night shift worker shift rotat scheme influenc worker toler night shift work impact health

D000089943;D000077260

T033;T048

multipl mechan confer broad spectrum insecticid resist tropic bed bug hemiptera cimicida modern resurg common cimex lectularius l tropic bed bug c hemipterus f thought primarili due insecticid resist mani report insecticid resist mechan c lectularius inform c hemipterus limit examin dichloro diphenyl trichloroethan ddt malathion deltamethrin permethrin lambda cyhalothrin resist under mechan sever c hemipterus strain australia queensland qld au malaysia kuala lumpur kl tanjung tokong tt christian ch green lane gl use surfac contact method synerg studi util piperonyl butoxid pbo tributyl phosphorotrithio def diethyl maleat dem molecular detect kdr mutat result demonstr c hemipterus strain possess high resist ddt pyrethroid moder high resist malathion synerg studi show deltamethrin resist strain signific p inhibit pbo contrast deltamethrin resist affect def dem similar find found lambda cyhalothrin resist malathion resist signific p h h combin mi lf mutat like confer super kdr characterist toward pyrethroid ddt c hemipterus

D001511;D007306;D011722

T131;T204;T109

sleepi safeti work among night shift nhs nurs sleepi associ night shift work nsw known advers affect worker health well associ advers safeti outcom recogn workplac hazard among healthcar worker

D006970;D009726

T047;T184;T097;T048;T033

impact depress anxieti comorbid occup outcom anxieti depress account consider cost organ driven presente reduc perform due attend work ill absente research focus impact depress less attent given anxieti comorbid present

D000041;D003863

T048;T184;T055

assess light exposur shift work nurs london dortmund relat recommend sleep circadian health shift work caus disrupt circadian physiolog process human bodi desynchron natur day night rhythm circadian disrupt thought explain associ shift work various long term diseas light unrival synchron zeitgeb circadian process inappropri light exposur plausibl play critic role develop health impair publish measur data actual light environ encount shift worker spars nurs work two hospit london uk dortmund germani wore light log dosimetri devic measur person light exposur continu week three differ season studi identifi quantifi sever characterist light exposur relat differ work pattern winter spring summer quantifi interindividu variat data enabl inform design light exposur intervent chang shift reduc unwant effect disrupt light exposur profil

D016273

T037

conserv nag motif critic catalyt activ galactinol synthas key regulatori enzym rfo biosynthesi galactinol synthas gol catalyz key regulatori step biosynthesi raffinos famili oligosaccharid rfos even though physiolog role regul enzym well studi littl known activ site amino acid structur function relationship substrat enzym present studi investig activ site amino acid structur function relationship enzym use combin three dimension homolog model molecular dock along seri delet site direct mutagenesi follow vitro biochem vivo function analysi studi activ site amino acid interact substrat chickpea arabidopsi gol enzym studi reveal gol protein possess gt famili specif sever conserv motif nag motif play crucial role substrat bind catalyt activ enzym delet entir nag motif delet substitut alanin residu motif result complet loss catalyt activ vitro condit furthermor disrupt nag motif cagol enzym disrupt vivo cellular function yeast well planta togeth studi offer new insight activ site amino acid substrat interact catalyt activ gol enzym demonstr nag motif play vital role substrat bind catalyt activ galactinol synthas affect overal rfo synthesi

D029681;D005700

T116;T126

anti sever acut respiratori syndrom coronavirus hyperimmun immunoglobulin demonstr potent neutral antibodi depend cellular cytotox phagocytosi n protein although coronavirus diseas covid vaccin provid signific reduct infect effect covid treatment remain urgent need

D000920

T043

smoke status factor associ covid hospit mortal among us veteran role smoke risk death among patient covid remain unclear examin associ hospit mortal covid smoke status factor unit state veteran health administr vha

D000086382;D014728

T047;T098;T067

hyperinsulinem euglycem clamp strengthen insulin resist nonclass congenit adren hyperplasia insulin sensit evalu hyperinsulinem euglycem clamp nonclass congenit adren hyperplasia nc cah due hydroxilas defici

D007333

T046

spier memori lectur analysi de novo design membran interact peptid membran peptid interact play critic role mani cellular organism function includ protect infect remodel membran signal ion transport peptid interact membran varieti way associ membran surfac either intrins disord conform well defin secondari structur peptid suffici hydrophob also insert vertic transmembran monom mani associ membran span helic bundl inde peptid progress stage process form oligomer bundl case structur peptid membran repres delic balanc peptid membran peptid peptid interact review literatur perspect sever biolog import system includ antimicrobi peptid mimic synuclein receptor tyrosin kinas ion channel also discuss use de novo design construct model test understand under principl provid use lead pharmaceut intervent diseas

D010455

T116;T121

doubl ph sensit nanotheranost polypeptid nanoparticl encapsul bodipi nir activ fluoresc enhanc photodynam therapi achiev accur fluoresc imag guid cancer therapi intellig system specif respons tumor microenviron need design achiev enhanc nir fluoresc photodynam therapi introduc dimethylamino function group bodipi dye use ph sensor acid condit coordin proton ph fluoresc quench due photo induc electron transfer pet process photosensit proton tumor cell lysosom ph pet process inhibit fluorophor emiss capac restor fluoresc enhanc fold result near infrar fluoresc offon transit insid tumor enhanc singlet oxygen product lysosom target capabl due substitut heavi atom iodin compound high singlet oxygen quantum yield dichloromethan addit use ph sensit amphiphil polypeptid poegma pe carrier wrap photosensit bdpi releas enough drug acid environ ph intracellular endosomeslysosom conduc adequ interact photosensit h effect enhanc fluoresc emiss product achiev precis fluoresc imag capabl extrem low background toxic

D005453

T070

insuffici evid exist natur trifluoroacet acid trifluoroacet acid tfa persist mobil pollut present ubiquit environ result studi report presenc pre industri sampl purport unaccount sourc tfa often claim exist natur examin evid natur tfa critic evalu measur tfa pre industri sampl ii examin likelihood tfa format hypothes mechan iii explor potenti tfa sourc deep ocean iv examin global budget tfa conclud presenc tfa deep ocean lack close tfa budget suffici evid tfa occur natur especi without reason mechan format argu paradigm natur tfa longer carri forward

D004785;D014874

T131

needl haystack reevalu old paradigm discoveri bacteri secondari metabolit cover natur product research midst renaiss usher modern understand microbiolog technolog explos genom metabolom explor unchart chemic space expand high throughput discoveri campaign becom increas clear design element influenc success bio geographi habitat communiti dynam culturinginduct method screen method derepl explor critic consider assumpt natur product discoveri revisit previous estim chemic rediscoveri discuss related studi design produc taxonomi frequenc analys biosynthet gene cluster public avail genom data highlight phylogenet bias influenc rediscoveri rate select exampl studi design level determin discoveri outcom discuss challeng opportun futur high throughput natur product discoveri

D055808

T062