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treatment syphili doxycyclin pregnant woman unabl desensit penicillin pregnant woman non ige mediat penicillin allergi treat syphili doxycyclin resolut infect evid advers outcom mother infant

D004342;D011251;D013587

T047;T046

clinic featur outcom paediatr patient isol colon crohn diseas adult studi suggest patient isol colon crohn diseas l cd exhibit uniqu characterist differenti patient ileo caecal l cd ulcer coliti uc aim character clinic featur outcom paediatr patient l

D003093;D003424

T047

impact sever acut respiratori syndrom coronavirus type children liver diseas joint european societi pediatr gastroenterolog hepatolog nutrit societi pediatr liver transplant posit paper children seldom affect sever form sever acut respiratori syndrom coronavirus type sar cov infect howev impact comorbid clinic present outcom sar cov children poor character includ chronic liver diseas cld take immunosuppress medic autoimmun liver diseas follow liver transplant lt although main target organ spectrum liver involv describ children infect sar cov present multisystem inflammatori syndrom children mis c hepatolog committe european societi pediatr gastroenterolog hepatolog nutrit espghan societi pediatr liver transplant split present evid base posit paper liver involv children sar cov infect impact cld well lt recipi children may exhibit acut liver injuri sar cov infect cld may experi hepat decompens prevent therapeut measur discuss

D000086382;D005762;D008107;D016031

T047;T091;T061;T067;T033

clinic characterist short term outcom children asparaginas associ pancreat acut pancreat signific toxic l asparaginas chemotherapeut agent use treat acut lymphoblast leukemia case seri describ short term clinic cours disposit patient develop asparaginas associ pancreat aap one quaternari pediatr center

D019283;D054198

T191;T047

mucos mast cell distribut gastrointestin tract children preliminari studi establish refer valu physiolog number distribut mast cell mcs pediatr gastrointestin gi tract well defin refer valu normal miss defin physiolog diseas defin cut systemat histolog explor mc distribut esophagus rectum healthi well patient gastrointestin food allergi gfa perform

D007413;D008407

T025;T023;T024

predictor outcom fulli cover stent treatment anastomot esophag strictur esophag atresia anastomot strictur follow surgic repair one common complic esophag atresia ea util esophag stent treat anastomot esophag strictur pediatr unclear primari aim evalu whether esophag stent conjunct dilat endoscop therapi prevent surgic strictur resect sr secondari aim evalu predictor success esophag stent evalu advers event stent placement

D004933;D004940

T047;T019

low mean nocturn baselin imped associ patholog acid exposur time children baselin imped bi mean nocturn baselin imped mnbi serv marker mucos integr patient patholog acid exposur time aet work aim investig associ bi mnbi aet children

D004941;D005764

T047

longitudin develop health relat qualiti life fatigu children home parenter nutrit aim studi describ longitudin develop health relat qualiti life hrqol fatigu children chronic intestin failur cif home parenter nutrit pn compar children general popul

D016331;D011788

T061;T078

neurodevelopment outcom children inherit liver diseas nativ liver evalu neurodevelopment status among children inherit cholestat liver diseas nativ liver variabl predict impair

D016738;D002779;D002780

T047;T019

benefit structur pediatr adult transit inflammatori bowel diseas transit observ studi evalu impact structur transit pediatr adult inflammatori bowel diseas ibd servic object patient outcom includ diseas flare admiss rate healthcar resourc use

D003092;D005762;D015212;D060305

T091;T058;T047

effect dihydropyridin calcium channel blocker blood pressur variabl sprint trial treatment effect approach increas visit visit blood pressur variabl vvbpv negat effect multipl organ system prior research suggest dihydropyridin calcium channel blocker ccb may reduc vvbpv attempt verifi high qualiti dataset robust statist methodolog

D004095;D006973

T047;T121;T109

narrat review antiplatelet anticoagul medic venous thromboembol prevent spine surgeri narrat review

D054556

T047

comparison outcom percutan vertebroplasti percutan kyphoplasti treatment kmmell diseas meta analysi meta analysi

D050815;D058498;D058866;D016103;D055009;D054854

T037;T047;T046;T061

method use generat consensus statement clinic practic guidelin primer spine surgeon research methodolog studi

D013131;D066231

T097;T023

call action treat dri eye diseas set foundat success surgeri dri eye diseas ded common diseas reduc qualiti life preval estim vari report high popul diagnosi complic multifactori etiolog disconnect clinic sign patient report symptomatolog critic preexist ded exacerb postop dri eye symptom reduc patient satisfact ocular surgeri highlight valu thorough evalu screen sign symptom ded prepar ocular surgeri articl review predispos exacerb factor ded present argument import adequ treat ded prior surgeri perspect patient provid briefli review current avail methodolog emphas util multimod diagnosi treatment algorithm optim outcom patient satisfact

D015352;D011788

T047;T184;T078

congenit cytomegalovirus hepat failur underrecogn complic congenit cytomegalovirus infect common congenit infect although infant congenit cytomegalovirus infect asymptomat birth subset readili appar clinic andor laboratori manifest includ hepat progress hepat failur previous describ term infant initi antivir treatment short birth present term infant congenit cytomegalovirus infect hepat progress hepat failur despit initi laboratori improv therapi

D003586;D007232;D017093

T047

steroid inject compart effect inject extensor pollici brevi subcompart alon patient de quervain diseas random control trial ultrasonographi us guid steroid inject improv accuraci inject patient de quervain diseas especi intracompartment septum although main lesion de quervain diseas patient septum stenos tenosynov extensor pollici brevi epb report know compar inject epb subcompart inject abductor pollici longus apl epb subcompart random trial compar result us guid steroid inject target subcompart epb subcompart alon patient de quervain diseas

D053684;D017496;D052256;D013708

T047;T037

scope review comparison approach measur genet heterogen psychiatr disord improv understand genet etiolog heterogen psychiatr condit may help us isol neurophysiolog final common pathway identifi upstream genet origin b facilit character condit phenotyp variat review aim identifi exist genet heterogen measur psychiatr literatur provid conceptu review mechan limit assumpt scopus databas search studi quantifi genet heterogen correl psychiatr phenotyp human genet data nineti studi includ eighti seven report quantifi genet correl five appli genom structur equat model three evalu departur hardi weinberg equilibrium one loci two appli novel approach known mixer found studi rigor measur genet etiolog heterogen across larg number marker develop approach may help better character biolog divers psychopatholog

D018740;D001523

T032;T048

epigenet studi suicid ideat behavior psychiatr disord associ elev risk suicid suicid behavior product interact mani risk factor genet environment factor henc epigenet research may help understand mechan lead suicid ideat behavior review discuss epigenet studi suicid ideat behavior epigenet modif like import suicid ideat behavior review studi found signific epigenet modif link suicid behavior rather ideat although sizabl research carri topic studi done small scale sampl futur research requir larger sampl better clinic character suicid phenotyp investig epigenet modif

D059020;D013405

T033

influenc httlpr polymorph postpartum depress posttraumat symptom postpartum depress ppd multifactor disord caus psycholog social also biolog factor httlpr polymorph promot region serotonin transport gene seem influenc ppd onset studi examin effect httlpr polymorph prenat postnat symptom depress posttraumat stress women

D019052;D013313

T048

assist reproduct technolog crohn diseas ulcer coliti systemat review meta analysi infertil may occur women crohn diseas cd ulcer coliti uc especi surgeri ileal pouch anal anastomosi ipaa assist reproduct technolog art may option safeti efficaci set base small cohort date perform systemat review meta analysi address data gap

D027724

T061

zip contribut hypox pulmonari hypertens drive phenotyp switch pulmonari arteri smooth muscl cell zip plasmalemm zinc transport report promot pulmonari vascular remodel pvr enhanc prolifer pulmonari arteri smooth muscl cell pasmc howev mechan zip facilit pasmc prolifer remain incomplet appreci acknowledg prolifer predispos phenotyp switch pasmc lead pvr given hypoxia trigger phenotyp switch pasmc zip mediat pvr studi aim explor whether zip mediat phenotyp switch pasmc contribut hypoxia induc pvr rat expos hypoxia week induc pvr primari rat pasmc cultur hypox condit hour induc prolifer immunofluoresc quantit revers transcript polymeras chain reaction western blot analysi perform detect express target mrnas protein edu incorpor dimethylthiazol yl carboxymethoxyphenyl sulfophenyl h tetrazolium assay conduct measur prolifer pasmc hypoxia upregul zip express mrna protein pulmonari arteri pasmc knockdown zip inhibit phenotyp switch pasmc induc hypoxia propos hif zipperk pathway could repres novel mechan under hypoxia induc phenotyp switch pasmc therapeut target zip could exploit treat pvr

D006976;D011651

T023;T046

efficaci hibiscus sabdariffa reduc blood pressur patient mild moder hypertens systemat review meta analysi publish random control trial aim assess efficaci hibiscus sabdariffa patient mild moder hypertens metabol syndrom met compar placebo antihypertens drug herbal product four databas search random clinic trial rcts examin efficaci h sabdariffa patient mild moder hypertens hypertens associ met data chang systol blood pressur sbp diastol blood pressur dbp extract analyz use review manag version total rcts particip analyz hibiscus sabdariffa signific reduc sbp dbp compar placebo mean differ p mm hg p subgroup analysi show chang sbp dbp statist signific patient hypertens wherea signific patient hypertens associ met h sabdariffa compar activ control antihypertens drug herbal chang sbp dbp statist signific p hibiscus sabdariffa effect reduc sbp dbp patient mild moder hypertens neither effect met superior antihypertens drug rcts requir determin long term efficaci h sabdariffa describ patient would benefit treatment

D031584

T002

noninvas respiratori support acut respiratori failur due covid noninvas respiratori support wide appli covid pandem provid narrat review benefit possibl harm noninvas respiratori support covid respiratori failur

D000086382;D063087;D012128;D012131

T046;T047;T061;T067

rare case pneumatosi cystoid intestinali bowel perfor secondari sepsi present case yo male intestin perfor pneumatosi cystoid intestinali consequ sepsi

D007416;D062645;D011006;D018805

T047;T061;T046

develop valid assess clinic impact real time alert detect inpati need opioid order duplic indic prospect studi need prn opioid order duplic indic lead medic error opioid relat advers drug event

D020000;D050316

T058;T170;T073

digit biomark depress screen wearabl devic cross section studi machin learn model depress preval mental disord undiagnos untreat half case wearabl activ tracker collect fine grain sensor data character behavior physiolog user ie digit biomark could use time unobtrus scalabl depress screen

D003863;D000072936

T048;T184;T073

e cigarett cessat content analysi quit vape communiti reddit e cigarett use also known vape increas dramat past year especi among younger demograph howev research found larg number e cigarett user want quit littl known uniqu aspect vape cessat critic inform develop relev resourc intervent e cigarett user want quit social media forum reddit provid opportun understand experi behavior chang quit vape perspect end user

D066300;D016540;D062789;D014029;D000072137

T109;T073;T055;T131;T048

compar effect enhanc patient instruct bowel prepar colonoscopi network meta analysi random control trial various enhanc patient instruct epi use bowel prepar bp previous meta analysi also demonstr efficaci epi increas colon polyp adenoma detect rate howev optim method adequ bp yet develop

D063731;D060145

T052;T170;T066

effect sar cov protein vascular permeabl sever acut respiratori syndrom sar cov infect lead sever diseas associ cytokin storm vascular dysfunct coagul progress lung damag affect sever vital organ seem patholog effect endotheli cell sar cov genom encod protein whose contribut diseas manifest especi endotheli complic unknown clone express protein human cell character endotheli respons overexpress individu wherea protein induc signific chang endotheli permeabl nsp nspca catalyt dead mutant nsp nsp also reduc cd increas von willebrand factor express il suggest endotheli dysfunct use propag base analysi protein protein interact ppi network predict endotheli protein affect viral protein potenti mediat effect appli ppi model identifi role sar cov protein tissu affect coronavirus diseas covid valid ppi network model found tight junction tj protein cadherin zo catenin affect nsp nspca nsp consist model predict overal work identifi sar cov protein might detriment term endotheli dysfunct therebi shed light vascular aspect covid

D002199;D054884

T040;T042

advanc care thalassaemia patient novel therapi thalassaemia group inherit disord haemoglobin synthesi characteris chronic anaemia vari sever current avail convent therapi thalassaemia mani challeng limit better understand patholog thalassaemia led develop new treatment option current clinic trial could potenti reduc red blood cell transfus burden rais haemoglobin level improv patient overal qualiti life review provid overview novel therapeut approach current develop advanc care thalassaemia patient

D013789;D017086

T047

role serolog molecular test diagnost transfus treatment autoimmun haemolyt anaemia autoimmun haemolyt anaemia aiha rare autoimmun diseas characteris haemolysi associ presenc immunoglobulin andor compon complement system red blood cell rbcs classifi warm cold antibodi mediat aiha accord temperatur autoantibodi bind optim rbcs clinician familiar procedur test use complet laboratori investig aiha good collabor clinician laboratori specialist correct sampl handl exact diagnost work extrem import correct classif proper therapeut manag aiha specialis serolog test procedur complex problem serolog test may exclud molecular test becom gold standard predict patient phenotyp order secur right antigen match blood aiha patient recent genotyp use instead serolog type complex adsorpt test paper offer descript various test differenti type aiha diagnost algorithm problem laboratori investig also present applic molecular method blood group type aiha elabor

D000744

T047

singl dose intraven ferric carboxymaltos infus versus multipl fraction dose intraven iron sucros treatment post oper anaemia colorect cancer patient randomis control trial recent clinic guidelin suggest treatment postop anaemia colorect cancer surgeri intraven iron reduc transfus requir improv outcom studi aim compar two intraven iron regimen anaem patient colorect cancer surgeri

D000740;D018798;D015179

T191;T047

promot physic activ peopl haemophilia memo movement person haemophilia expert consensus project regular physic activ increas joint stabil function reduc risk injuri improv qualiti life peopl haemophilia pwh howev recent review literatur show appropri physic activ sport alway promot enough overal manag pwh group italian expert haemophilia care undertook consensus procedur provid practic guidanc recommend physic exercis programm pwh clinic practic three main topic identifi haemophilia impact movement physic activ recommend pwh choic manag sport activ pwh ten statement formul modifi delphi approach use reach consensus group also creat practic tool propos differ physic activ frequenc differ age group movement pyramid share discuss patient caregiv conclus opinion work group physic activ consid low price intervent preventreduc occurr chronic diseas encourag pwh obtain multipl physic psycholog benefit futur research includ prospect studi focus particip sport specif risk exposur clinic outcom

D006467

T047

vasovag reaction whole blood apheresi donor cross section studi donor haemovigil data itali acut delay vasovag reaction vvr frequent advers reaction ar associ donat aim studi provid data italian donor haemovigil system contextualis vvr data within intern framework well evalu among first time donor associ gender age preval vvr compar ar

D001781;D019462

T047;T061

preval chikungunya dengu zika virus blood donor systemat literatur review meta analysi blood transfus centr understand epidemiolog emerg diseas transmiss transfus blood compon risk transmiss arbovirus rout becom appar recent year aim studi summaris report preval viraem rate seropreval andor antigen detect chikungunya chikv dengu denv zika zikv virus blood donor accord screen test use world region

D065632;D003715;D000071244;D000071243

T047;T005

brain food rethink food born toxocariasi human toxocariasi neglect tropic diseas actual global distribut signific impact global public health infect lead sever serious condit human includ allerg ophthalm neurolog disord epilepsi caus common roundworm speci toxocara cani toxocara cati human becom accident infect via ingest egg larva toxocara egg deposit ground infect dog cat fox defec egg contamin crop graze pastur subsequ food anim howev transmiss toxocara human via food consumpt receiv relat littl attent literatur establish risk contamin food pose public renew research focus requir review discuss current known food born toxocara transmiss highlight gap understand requir attent outlin potenti prevent strategi could employ safeguard consum health

D009422;D017166;D014120

T204;T047

explor role traumat event exposur tobacco depend treatment outcom among african american african american like die tobacco relat diseas less like quit smoke white counterpart evid greater preval posttraumat stress disord ptsd among african american underscor import studi effect traumat event exposur tobacco depend treatment outcom group secondari analysi data previous complet random control trial examin effect traumat event exposur eg serious accid tobacco depend treatment outcom well moder effect effect adapt smoke cessat treatment sampl n african american smoker new york citi traumat event exposur signific impact tobacco treatment outcom moder relationship treatment type outcom sampl result may driven uniqu sampl characterist may also indic averag level traumat event exposur signific impact tobacco treatment outcom among african american futur research examin effect higher level traumat event exposur treatment outcom well investig factor under trauma expos individu difficulti reducingquit smoke larger divers african american sampl

D016540;D014029

T048;T055

olfactori acuiti exaltolid test differ women sporad studi reveal sensit exaltolid depend estrogen blood level women

D007783

T109

effect head movement restrict kinemat spine lift lower task studi aim examin effect head movement restrict relat angl deriv use stepwis segment approach lift lower task ten healthi men lift lower box use two style stoop squat two load ie bodi weight perform task two instruct head postur flex neck keep contact chin chest task cycl instruct free head postur neck flexion signific affect flexion angl segment spine specif lumbar part addit postur signific affect deriv relat angl manifest latenc spine segment movement cephalad caudad caudad cephalad pattern conclus neck flexion awkward postur could increas risk low back pain lift lower task occup environ practition summari littl inform avail effect neck flexion spine segment kinemat movement pattern specif lumbar spine result experiment studi show neck flexion increas risk low back pain increas lumbar flexion angl spine awkward postur

D017770;D017116

T052;T047;T184

regul microrna mir p enhanc sensit cisplatin via regul small interf rna sirna anti human agtd autophagi non small cell lung carcinoma nsclc emerg drug resist hinder treatment malign tumor autophagi play import role tumor chemotherapi resist howev mechan non small cell lung cancer nsclc well research aim investig role mir p cisplatin resist via regul autophagi relat protein atgd autophagi cell viabil apoptosi fluoresc intens gfp lc rfp gfp lc determin use cell count kit cck assay flow cytometri laser scan confoc microscop analysi respect level lciilci p atgd detect western blot result show sensit cisplatin nsclc cell regul mir p mimic treatment induc promot cell apoptosi inhibit autophagi mechanist studi identifi atgd direct target mir p moreov atgd sirna also could revers mir p inhibitor induc regul atgd ration lciilci regul p express find indic mir p could regul sensit cisplatin nsncc cell regul autophagi mediat atgd therefor mir p may act potenti therapeut target treatment nsclc

D001343;D002289;D008175

T043;T191

parent attach orient interview support children memori mild distress event parent attach orient predict children memori distress life event parent less secur close relationship tend children less accur memori report studi examin whether social support interview would reduc differ children memori perform associ parent attach children year n primari caretak took part preschool attach classif system pac moder distress event children preschool age base strang situat procedur children memori event test short thereaft either support non support interview non support condit children whose parent score higher attach avoid provid lower proport correct free recal howev associ signific children support condit addit higher parent attach anxieti predict lower proport correct free recal children high avoid parent children parent lower attach avoid direct question age differ proport correct proport incorrect favour older children find provid insight interview techniqu time memori retriev benefit children insecur parent

D011939;D010290

T102;T041;T099

optim extract bioactiv detect celeri leaf flavonoid use bp neural network combin genet algorithm respons present studi ultrasound assist extract employ extract general flavon celeri leav use respons surfac methodolog bp neural network model genet algorithm ga effect temperatur time solid liquid ratio ethanol concentr extract result assess box behnken design optim process perform ga bp result show optim condit ethanol concentr temperatur c extract time min addit signific antioxid activ vitro bacteriostasi observ found total flavonoid celeri leav exert strong inhibitori effect escherichia coli staphylococcus aureus bacillus subtili addit consider dpph oh scaveng effect exert flavonoid therefor flavonoid celeri leav consid natur antioxid bacteri inhibitor

D000077102;D005419;D010936;D018515

T121;T002;T109;T123;T127

multidimension accultur accultur stress alcohol drug use adult latinx immigr studi use multidimension accultur framework ie cultur practic ident valu investig link alcohol drug use latinx immigr us cross section studi test link measur accultur languag base hispanic american cultur ident famil accultur stress alcohol drug use control age gender adult year old latinx immigr women complet measur past month behavior spanish english result show american relat alcohol use sever heavi episod drink drug use sever drug use accultur stress relat alcohol use sever drug use sever drug use heavi episod drink famil invers relat drug use sever drug use alcohol use sever heavi episod drink cultur ident hispanic relat alcohol drug use consist previous research languag base measur accultur us american accultur stress relat alcohol drug use increment valid multidimension accultur approach limit intervent adapt latinx immigr address stress reduct mitig adopt receiv cultur practic

D054242;D004364

T121;T098

influenc distress cope relationship perceiv racial discrimin cannabi use among black colleg student approxim one five black student report cannabi use associ academ challeng mental health interperson problem understand motiv use cannabi among black student predomin white institut pwis warrant research perceiv racial discrimin prd believ one treat unjust due race relat substanc use variabl associ poor cope depress anxieti given research unavail black colleg student factor structur everyday discrimin scale ed use chronic base code first aim studi examin factor structur chronic base version ed second aim investig whether distress cope interven construct prd cannabi use among black colleg student particip recruit midwestern pwi n complet ed cope subscal comprehens marijuana motiv measur report past year cannabi use factor analysi examin measur model ed path analysi assess mediat model two factor model assess subtl blatant prd ed fit data path analysi reveal distress cope fulli mediat relationship subtl prd cannabi use distress cope mediat relat blatant prd cannabi use institut might focus reduc prd provid support black student lessen link distress cope cannabi use

D002188;D063505

T121;T002;T109;T167;T054

bioconvers studi xylitol ethanol product debaryomyc hansenii aerat medium substrat composit influenc debaryomyc hansenii employ studi initi influenc oxygen avail xylos xylitol ferment paramet consid one critic variabl bio alcohol accumul apart air suppli ferment process stir vortex vvmin addit aerat rate vvmin effect discuss furthermor chang ferment medium composit well compar analysi hansenii behavior respect ferment glucos xylos mixtur solut aim produc xylitol ethanol bioproduct perform purpos specif growth rate biomass product specif substrat uptak rate overal biomass yield specif xylitol format rate overal xylitol yield valu calcul appli differenti method kinet data aerat influenc clear evinc sinc faster xylos metabol aerat valu close vvmin note yeast exhibit sequenti substrat consumpt first glucos xylos maximum xylitol yield kg kg obtain vvmin airflow remark signific reduct paramet quot air suppli valu

D055165;D014993

T004;T121;T109

major differ particl size minor differ releas profil case studi solid lipid nanoparticl solid lipid nanoparticl sln wide use varieti drug deliveri rout outstand advantag control drug releas releas sln domin mani factor among particl size sln critic one aim project explor relationship drug releas profil particl size sln sln synthes via hot high pressur homogen hph method budesonid bud use model drug bud sln bud sln increas particl size obtain ie nm prepar sln good encapsul effici drug load capac stabil vitro releas behavior studi show cumul releas bud sln tris maleat tris media neglig tris plus pancreatin media tris ethanol media obey ritger peppa model first order kinet model respect notic releas behavior sln extent relat averag particl size sln correl insignific intersect degre particl size distribut great studi provid new idea understand vitro releas sln certain referenc valu research develop novel nanomedicin

D008055;D053758

T073;T109

rang hip abduct prevent reconstruct surgeri cerebr palsi longitudin registri studi children background purpos hip disloc cerebr palsi cp caus alter muscl forc joint typic hip posit adduct flexion inward rotat prevent surgeri includ adductor psoa lengthen apl varus derot osteotomi vdro proxim femur assess chang hip abduct rang oper patient method data obtain swedish surveil programm cp rang hip abduct month surgeri assess children underw apl vdro data hip per child assess ordinari linear regress use result children underw apl mean rang abduct increas confid interv ci preoper ci month children underw vdro respect mean valu ci ci mean differ preoper abduct side greater children underw unilater ci bilater ci vdro month postop differ side almost unchang interpret rang hip abduct increas apl remain unchang vdro may explain normal develop hip displac oper differ abduct side substanti affect whether vdro perform uni bilater

D016059

T042;T201

two epidem pandem collis prescript drug misus racism covid present studi investig relationship perceiv racial discrimin prescript drug misus pdm among asian black latinx american covid crisi us racialethn minor may uniqu affect two nation one global pandem opioid crisi racism covid opioid death rate increas among mani group prior pandem countri wit increas racial act peopl color across spectrum spring summer month world covid outbreak studi shown clear link perceiv racial discrimin substanc abus outsid global pandem identifi studi done backdrop global health pandem separ hierarch regress reveal signific associ perceiv racial discrimin pdm black american asian american latinx individu find build scant literatur pdm divers sampl establish relationship perceiv racial discrimin pdm previous identifi abus substanc futur post pandem substanc misus intervent consid influenc perceiv racial discrimin help individu recov aftermath stress trifecta

D000086382;D063487;D063505

T033;T047;T054;T067

biomark panel predict recurr free surviv ulcer primari cutan melanoma ulcer independ advers prognost factor cutan malign melanoma cmm howev need addit prognost marker identifi patient ulcer stage ii cmm high risk recurr aim studi examin prognost impact braf mutat prolifer presenc tumour infiltr lymphocyt til primari ulcer cmm

D008545;D012878

T191

eat physic activ pattern day night shift em clinician object em clinician work shift provid hour care shift work link metabol diseas em clinician report overweight obes inabl store food vehicl combin limit overnight dine establish unpredict job demand lead relianc conveni fast food object studi describ eat physic activ pattern among em clinician day shift method em clinician throughout unit state particip studi involv four hour monitor period particip wore activ monitor measur physic activ level remot food photographi use collect dietari data two work day two day repeat measur analysi varianc conduct compar energi macronutri intak activ level day night worker shift result analyz data em clinician yrs old control sex work night shift consum kilocalori p total fat p compar day shift worker night shift worker fewer step p sedentari time p less moder activ p shift compar day worker conclus among em clinician night shift associ greater energi intak decreas physic activ shift may contribut posit energi balanc weight gain overtim increas risk metabol diseas

D004632;D014940

T058;T093;T061;T078

laparoscop splenic arteri aneurysmectomi icg guid partial splenectomi altern approach herein report case volumin splenic arteri aneurysm saa diagnos year old caucasian male patient endovascular treatment failur consid volumetr aneurysm increas recurr symptom laparoscop splenic arteri aneurysmectomi partial splenectomi guid indocyanin green fluoresc icg perform conserv strategi lead save spleen volum cm avoid postsplenectomi thrombocytosi infect potenti immunodefici overwhelm postsplenectomi infect syndrom opss preserv pancreat vascular prevent distal pancrea injuri

D000783;D010535

T190;T061;T046;T060

novel studi hypermnesia book read year ago memori increas across repeat test without studi find known hypermnesia eg erdelyi h kleinbard j ebbinghaus decay time growth recal hypermnesia day journal experiment psycholog human learn memori studi first examin hypermnesia recognit test long delay learn test current experi examin hypermnesia popular novel across retent span year particip took two test separ hour novel previous read test ident question present differ order found hypermnesia across recognit test due within test memori improv hypermnesia decreas function retent time due increas item loss longer delay propos guess hypothesi account result suggest increas item loss part due greater instabl memori longer interv

D011939;D011932

T056;T041

bacteriocin product inhibit bacillus subtili lactobacillus paracasei hd indirect cocultur system broad spectrum antimicrobi peptid name paracin produc lactobacillus paracasei hd isol chines sauerkraut juic studi influenc cocultiv communic mechan l paracasei hd bacillus subtili investig two bacteri strain grown monocultur indirect cocultur growth bacteria bacteriocin product well transcript level lux l paracasei hd spoa b subtili monitor bacteriocin product cell number increas signific l paracasei hd cell indirect cocultur b subtili bacteriocin produc l paracasei hd prevent growth sporul b subtili indirect cocultur b subtili express lux l paracasei hd increas exponenti growth phase decreas stationari phase compar monocultur express spoa b subtili drop indirect cocultur compar monocultur indic upregul lux due respons secret compound produc b subtili result show l paracasei hd amens b subtili b subtili commens l paracasei hd

D001430;D001937;D000069980

T116;T007;T002;T123;T168

effect zinc express apoptosi relat gene freez thaw damag adipos tissu deriv mesenchym stromal cell present studi perform investig effect zinc supplement freez thaw damag adipos tissu deriv mesenchym stromal cell msc mice studi cellular viabil gene express profil apoptosi slow freez method conduct sampl treat zinc dose viabil increas group zinc comparison control group gene express studi show group zinc fas bax caspas regul regul bcl observ group zinc p protect regul group studi present studi show dose zinc rather safe toxic increas cellular viabil amelior express apoptosi relat gene intrins extrins pathway

D059630;D015032

T025;T121;T196;T123

intox without anticip disentangl pharmacolog expect effect alcohol pharmacolog effect alcohol execut function crave subsequ alcohol seek well document yet insuffici methodolog control within exist alcohol administr paradigm meant relat import alcohol pharmacolog anticipatori effect remain need elucid

D007266

T041

examin two differ approach studi femor neck fractur toward relev rodent model femor neck fractur massiv person health programm burden method studi femor neck strength across combin trabecular cortic compon therefor essenti rodent ovariectomi induc osteoporosi model common coupl ex vivo point bend method measur chang femor cortic diaphysi load direct use assess properti often non physiolog moreov ovariectomi model link mark weight gain influenc biomechan properti herein explor whether physiolog axial ex vivo load protocol appli femor neck sampl ovariectomis ovx rodent provid anatom relev model assess strength examin use mous rat femur load constrain unconstrain configur respect explor whether weight correct increas util accord mid shaft proxim half femur ovx sham oper sham mice methacryl anchor head load parallel diaphysi constrain altern femur ovx sham rat isol intact axial load hip knee joint articular surfac unconstrain yield displac stiff maximum load resili measur fractur pattern classifi effect bodi weight correct via linear regress method simpl divis assess data reveal signific defici biomechan properti ovx mous femur load constrain configur weight correct linear regress addit evalu rat femur biomechan unconstrain load demonstr greater variat weight correct simpl divis improv scope reveal signific ovx impact conclud greater femor neck fractur suscept inde measur ovx rodent long multipl biomechan paramet report care taken choos method assess load bear strength weight correct appli studi advanc establish relev rodent model studi femor neck fractur

D005265;D010024

T047;T037

clinic implic lta h genet polymorph patient chronic obstruct pulmonari diseas leukotrien hydrolas lta h associ inflamm emphysema nevertheless clinic implic lta h genet polymorph chronic obstruct pulmonari diseas copd understudi date prospect studi perform investig clinic implic lta h genet polymorph patient copd aa ga gg type genet polymorph lta h assay patient copd baselin patient follow month baselin number particip aa ga gg type lta h rs copd group n wherea control group n p follow variat respect forc expiratori volum one second fev min walk distanc mwd bode bodi mass index obstruct dyspnea exercis capac similar patient aa ga type lower gg type patient gg type hospit patient aa p ga p type respect cumul hospit free rate patient gg type lower patient aa ga type respect p compar copd patient aa ga type patient gg type posit correl smoke hospit wors fev mwd bode index current studi suggest gg type ltah predispos factor copd develop function declin exacerb patient copd

D029424

T047

evid base therapeut hyperglycemia hospit noncrit ill patient hyperglycemia hospit patient either without diabet common serious cost healthcar problem evid accumul year associ hyperglycemia signific increas morbid mortal surgic medic patient base document link hyperglycemia poor outcom clinic guidelin profession organ recommend treatment hospit hyperglycemia therapeut goal maintain blood glucos bg level less mgdl insulin therapi remain mainstay glycem manag inpati set use non insulin antidiabet drug hospit set limit littl data avail regard safeti efficaci howev inform use incretin base therapi inpati increas past year review aim summar differ treatment strategi hyperglycemia hospit noncrit patient support observ studi clinic trial insulin non insulin drug addit propos protocol help manag import clinic problem

D003920;D006943

T033;T047

effect coronavirus pandem pediatr critic care fellowship train object assess impact coronavirus covid pandem pediatr critic care medicin pccm fellowship train cross section survey program director pds fellow design cross section internet base survey set accredit council graduat medic educ acgm accredit pccm fellowship program unit state subject pccm pds fellow result total pds fellow respond nation survey rate respect major respond agre medic educ negat impact covid pandem pds survey note signific decreas patient census sinc march cite decreas report traine less procedur experi respond report educ least part provid virtual learn platform near half exclus remot learn without person session fifti percent pds fellow report decreas learner engag virtual didact compar person educ major pds report specif decreas simul procedur skill train ultrasound train pds fellow report redeploy adult patient care northeastern program highest rate univari analys decreas pds confid traine procedur skill associ report decreas number procedur perform p number procedur skill didact session p chang unit census associ less pds confid fellow medic knowledg p fellow manag skill p fellow procedur skill p larger decreas patient census correl larger decreas confid conclus covid pandem signific impact educ clinic train pccm fellow knowledg topic assist pds curriculum chang futur address gap learn occur

D000086382;D058873

T047;T067

human papillomavirus self sampl long term non attend cervic cancer screen randomis feasibl studi estonia organis cervic cancer screen start estonia particip still low human papillomavirus hpv self sampl prove increas screen uptak studi address feasibl hpv self sampl accept method among long term screen non attend

D052685;D030361;D002583

T191;T047;T005

alkenylbenzoquinon compound fruit maesa lanceolata exhibit potent cytotox antibacteri antirad scaveng activ phytochem studi methanol extract fruit maesa lanceolata result isol new alkenylbenzoquinon alongsid known compound z dihydroxi methyl pentadec enyl benzoquinon dihydroxi methyl nonadec enyl benzoquinon dihydroxi methyl tridecyl benzoquinon r r e hydroxytetraeicosanoyl aminooctadec ene triol monopalmitin glyceryl palmit lupeol glucopyranosid sitosterol structur compound establish mean spectroscop nmr spectrometr techniqu ms isol compound assess antibacteri cytotox antirad activ compound show moder activ staphylococcus warneri dsmz compound inact two quinon signific cytotox ic valu respect weak activ toward dpph radic ic gml

D005638;D000076643

T002;T168

predictor declin renal function year evar exist copious short term data regard renal function follow infra renal endovascular abdomin aortic aneurysm repair evar long term analysi spars singl institut retrospect review predictor renal function declin year elect evar

D017544;D019917;D057510

T047;T061

famili sex communic among arab american young adult mix method studi signific gap understand sexual health arab american purpos studi explor famili sex communic among arab american young adult associ gender sexual attitud use parallel mix method design administ electron survey n subsampl particip particip five focus group observ converg find particip report rare occurr famili sex communic women report less comfort men famili sex communic often unspoken reinforc prevail social norm gender differ report base sex communic topic common sourc sex inform peersfriend focus group particip perceiv parent conserv less knowledg sex futur research strategi bridg generat differ need promot famili base sex communic given multipl teachabl moment home

D018912;D012725

T032;T053;T098;T055

quantifi impact capac constraint econom evalu applic precis medicin exampl precis medicin complex intervent featur test treatment compon complex often barrier introduct intervent econom evalu attempt determin impact barrier cost effect intervent studi present case studi econom evalu illustr valu implement method may use quantifi impact capac constraint decis analyt model

D057285;D020794

T116;T091;T192;T061;T126

effect laparoscop sleev gastrectomi drug pharmacokinet given feasibl efficaci laparoscop sleev gastrectomi lsg becom wide accept bariatr surgeri patient clinic diagnos sever obes lsg induc anatom chang subsequ weight loss may affect drug pharmacokinet pk consequ impact dose regimen review aim examin effect lsg drug pk identifi relev gastrointestin physiolog alter

D015390;D010535;D009767;D004364

T047;T060;T121;T061

use expert elicit among comput model studi health research systemat review expert elicit ee use across disciplin estim input paramet comput model research inform spars conflictu

D005104;D012107

T057;T097;T170;T169;T077;T062;T081;T096

knowledg attitud practic barrier toward pharmacovigil advers drug reaction report among healthcar profession turkey systemat review global pharmacovigil pv crucial patient safeti proper use drug spontan report advers drug reaction adr profession oblig everi healthcar profession hcps purpos systemat review analyz exist literatur knowledg attitud practic kap level hcps regard pv adr report turkey

D064420;D060735

T062;T046;T037

biflavonoid twig leav cephalotaxus oliveri mast glucosidas inhibitori activ three new biflavonoid umcephabiovin c e along fourteen known compound isol twig leav cephalotaxus oliveri structur configur elucid uv ir nmr ecd hr esi ms spectra compound exhibit signific glucosidas inhibitori activ ic valu respect compound show moder cytotox bafti cell line

D044946;D032483

T121;T002;T109

phytochem zingiberacea famili exhibit potenti sar cov main proteas identifi ration comput aid drug design coronavirus diseas covid creat huge social econom human health crise global discoveri specif drug becom new challeng research structur base virtual screen hous databank contain phytochem zingiberacea famili perform main proteas pro crucial enzym sar cov rigor dock adm studi top score twenti hit result vs perform ns molecular dynam follow mmpbsa bind free energi g bind calcul kz also perform two hit show good interact crucial amino acid residu pro cys excel adm properti fair g bind valu kjmol averag protein ligand complex rmsd apo protein rmsd therefor seed extract alpinia blepharocalyx rhizom extract kaempferia angustifolia contain kz respect may use covid proper biolog screen two novel scaffold could exploit potent sar cov pro inhibitor

D000086382;D030521

T047;T002;T067

quantifi public rate time public american urolog associ podium present american urolog associ aua annual meet serv premier platform present unpublish research urolog among select abstract podium present repres impact submiss podium present receiv larg audienc confer attend social media post unclear often manifest public peer review journal

D003226;D012955;D014572

T073;T170;T094;T091;T068

associ excess joint laxiti wider hill sach lesion anterior shoulder instabl excess general joint laxiti negat prognost factor joint instabl studi determin relationship bipolar bone loss anterior shoulder instabl

D000070896;D007593;D012783;D012785

T023;T047;T037;T033;T030

salivari melatonin rhythm prostat cancer caplif studi analyz associ salivari melatonin rhythm prostat cancer pca

D002940

T040

one boni morpholog two patholog entiti sex base differ patient borderlin hip dysplasia undergo hip arthroscopi sex base differ larg uncharacter patient borderlin hip dysplasia bhd undergo hip arthroscopi

D057925;D006617

T190;T046;T037

cardiovascular progerin suppress lamin restor rescu hutchinson gilford progeria syndrom hutchinson gilford progeria syndrom hgps rare disord character prematur age death main myocardi infarct stroke heart failur diseas provok progerin variant lamin express differenti cell patient look healthi birth symptom typic emerg first second year life assess revers progerin induc damag relat contribut specif cell type critic determin potenti benefit late treatment develop new therapi

D011371

T047

obes impair enthesi heal rotat cuff repair rat model overweight obes associ poor outcom increas risk failur rotat cuff rc surgeri howev effect obes enthesi heal well character

D017006;D000070636

T037;T047;T023;T033

knowledg broker facilit intervent improv use standard assess tool physic therapist cluster random trial compar two method knowledg broker support improv standard assess use

D059825

T097

supin versus prone percutan nephrolithotomi complex stone multicent random control trial high qualiti evid compar supin prone percutan nephrolithotomi pcnl treatment complex stone lack studi aim compar outcom supin posit sup prone posit pro pcnl

D056888

T058

understand extrem elev dizzi handicap inventori score analysi predict factor dizzi handicap inventori dhi measur impair qualiti life due dizzi higher score indic greater impair littl known clinic featur predict extrem elev dhi score eedhi

D004244;D015837

T047;T184

opioid usag pain control benign oropharyng surgeri observ prospect studi littl data avail opioid usag adult popul benign oropharyng surgeri object evalu opioid prescrib pattern opioid consumpt patient pain pattern follow benign oropharyng surgeri specif tonsillectomi adenoidectomi tonsillectomi alon expans sphincter pharyngoplasti

D000701;D010098

T131;T121;T109

modul cgas sting pathway nicotinamid ribosid alzheim diseas numer studi demonstr global decreas nicotinamid adenin dinucleotid nad age declin associ develop sever hallmark age reduc mitophagi neuroinflamm process thought play signific role progress alzheim diseas ad augment nad oral administr precursor nicotinamid ribosid nr reduc senesc affect cell attenu dna damag neuroinflamm transgen appp murin model ad inflamm mediat microgli cell play import role progress ad neurodegen diseas cytoplasm dna sensor cyclic gmp amp synthas cgas downstream stimul interferon gene sting generat interferon signatur characterist senesc inflammag brain ad mice elev cgas sting observ ad mous brain human ad fibroblast normal nr intervent also increas mitophagi improv cognit behavior appp mice studi suggest modul cgas sting pathway may benefit ad patient possibl disord character compromis mitophagi excess neuroinflamm

D000544

T048;T047

carmn evolutionarili conserv smooth muscl cell specif lncrna maintain contractil phenotyp bind myocardin vascular homeostasi maintain differenti phenotyp vascular smooth muscl cell vsmcs landscap protein code gene compris transcriptom differenti vsmcs intens investig mani gap remain includ emerg role noncod gene

D009119

T039;T067

intermedi invas fungal sinus distinct entiti acut fulmin chronic invas fungal sinus current classif system invas fungal sinus if includ acut aif chronic cif phenotyp phenotyp display histopatholog evid tissu necrosi differ presenc angioinvas extent necrosi diseas progress aif defin rapid onset symptom cif slowli progress week howev subset if patient fit clinic present histopatholog characterist either aif cif

D000072742;D012852

T047

role lymphadenectomi radic cystectomi nonmuscl invas bladder cancer result multi institut experi lymph node dissect lnd radic cystectomi rc muscl invas bladder cancer studi extens role lnd nonmuscl invas bladder cancer nmibc remain incomplet defin herein aim assess associ extent lnd rc nmibc local pelvic recurr free surviv lprs cancer specif surviv css overal surviv os

D008197

T061

supracerv hysterectomi protect mesh complic minim invas abdomin sacrocolpopexi popul base cohort studi patient although minim invas robot laparoscop abdomin sacrocolpopexi misc becom new gold standard durabl pelvic organ prolaps repair vagin mesh controversi current literatur limit object studi reoper mesh complic misc

D019060

T061

posit surgic margin rate retzius spare robot assist radic prostatectomi contemporari unselect cohort aim report posit surgic margin psm rate retzius spare robot assist radic prostatectomi rs rarp unselect real life cohort patient treat fellowship train urolog depart

D000072662

T033;T023

find men preoper ga prostat specif membran antigen positron emiss tomographycomputer tomographi multiparametr magnet reson imag compar total embed radic prostatectomi histopatholog implic diagnosi manag prostat cancer multiparametr magnet reson imag mpmri fail identifi men signific prostat cancer prostat specif membran antigen positron emiss tomographycomputer tomographi psma petct recommend stage prostat cancer addit benefit mpmri alon local evalu prostat cancer unclear studi aim evalu abil mpmri psma petct individu combin predict tumor locat gleason score robot assist laparoscop radic prostatectomi ralp histolog

D000081364;D000072078

T060

midterm result isol medial patellofemor ligament reconstruct first line surgic treatment skelet immatur patient irrespect patellar height trochlear dysplasia medial patellofemor ligament reconstruct skelet immatur patient experi later patellar disloc report yield good result whether boni abnorm patellar height trochlear dysplasia address addit topic discuss

D007593;D031222;D057071

T033;T030;T037

deepsens physic guid deep learn paradigm anomali detect soil gas data geolog co storag site driven collect enorm amount stream data sensor emerg internet thing need develop robust detect techniqu identifi data anomali increas recent algorithm anomali detect requir select base type data studi propos predict anomali detect techniqu deepsens appli soil gas concentr data acquir sensor use environment character prospect co storag site queensland australia deepsens take advantag deep learn algorithm predictor modul use process base soil gas method basi anomali detector modul propos predictor framework leverag power convolut neural network algorithm featur extract simultan captur long term tempor depend long short term memori algorithm propos process base anomali detect method cost effect altern convent concentr base soil gas methodolog reli long term baselin survey defin threshold level result indic propos framework perform well diagnos anomal data soil gas concentr data stream robust efficaci deepsens verifi data set acquir differ monitor station storag site

D000077321

T066

substanti reduct particul matter air pollut across europ spatiotempor model analysi air pollut pose largest environment health risk europ particul matter pm concentr harm pollut repres main air qualiti indic sustain develop goal sdgs air qualiti surveil europ base monitor network coars comprehens evalu air pollut burden link raw pollut data remot sens product use bayesian geostatist model first time estim pan european near surfac concentr fine pm coars pm particl km spatial resolut evalu complianc air qualiti threshold set world health organ european union eu assess countri wise trend result show last year pm pm concentr declin credibl interv respect number peopl expos pm level threshold decreas pm decreas smaller expos although clear improv overal pictur stricter measur need ensur complianc guidelin

D000393;D000397

T131;T069;T080

nitric oxid cancer give take away mechanist role nitric oxid cancer progress import consider sinc discoveri endogen generat free radic nonetheless impact signal molecul seem contradictori pro antitumorigen complic develop cancer treatment base modul flux tumor fundament level low level drive oncogen pathway immunosuppress metastasi angiogenesi higher level lead apoptosi reduc hypoxia also sensit tumor convent therapi howev clinic outcom depend type stage tumor well tumor microenviron viewpoint current understand concentr spatial tempor depend respons correl potenti treatment prevent technolog strategi

D009569

T121;T197

model noncanon rna base pair coars grain isrna model noncanon base pair contribut crucial three dimension architectur larg rna molecul howev accur model remain open challeng rna structur predict report promis coars grain cg isrna model predict noncanon base pair larg rnas molecular dynam simul introduc five bead per nucleotid cg represent reserv three interact edg nucleobas isrna accur model various base pair interact includ canon noncanon base pair benchmark test indic isrna achiev compar perform atom model de novo model noncanon rna structur addit isrna abl refin structur predict larg rnas rna puzzl challeng final graphic process unit acceler introduc speed sampl effici isrna larg rna molecul therefor cg isrna model report offer reliabl approach predict structur dynam larg rnas

D056004;D012313

T044;T066;T114

curcumin induc membran properti chang dmpc multilamellar vesicl effect membran destabil molecul curcumin load multilamellar vesicl curcumin cur major bioactiv compon turmer curcuma longa common use spice tradit medicin india cur possess wide rang pharmacolog benefit includ antioxid anticarcinogen antimutagen anti inflammatori anti alzheim anti parkinson effect cur membran interact believ reason biolog activ cur sever research group model interact cur artifici model lipid membran use various techniqu nuclear magnet reson nmr small angl x ray scatter sax differenti scan calorimetri dsc howev mechan action still unclear fluoresc probe base techniqu could advantag studi cur lipid membran interact due sensit toward local environ multiparametr natur work use intrins fluoresc properti cur investig cur induc physic properti chang dimyristoyl sn glycero phosphocholin dmpc multilamellar vesicl mlvs various cur concentr ration result steadi state fluoresc intens fluoresc anisotropi temperatur depend fluoresc intens temperatur depend fluoresc anisotropi quench experi propos model show concentr depend effect cur dmpc bilay membran suggest low concentr mol cur homogen distribut dmpc bilay membran solid gel sg liquid crystallin lc phase high concentr mol cur molecul form segreg domain fluidiz membran phase howev cur induc fluidize less pronounc lc phase cur molecul domain partit bilay core effect membran destabil molecul bile salt capsaicin cap piperin pip cur load dmpc multilamellar vesicl studi work also show cur stabil effect dmpc membran high concentr

D003474;D004134

T130;T121;T109

ferumoxytol nanoparticl target biofilm caus tooth decay human mouth sever tooth decay associ iron defici anemia disproport burden suscept popul current modal insuffici sever case pathogen dental biofilm rapid accumul requir new antibiofilm approach show ferumoxytol food drug administr approv nanoparticl formul treat iron defici exert altern therapeut activ via catalyt activ hydrogen peroxid target bacteri pathogen biofilm suppress tooth enamel decay intraor human diseas model data reveal potent antimicrobi specif ferumoxytol iron oxid nanoparticl ferionp biofilm harbor streptococcus mutan via preferenti bind promot bacteri kill situ free radic generat analysi indic target mechan involv interact ferionp pathogen specif glucan bind protein minim effect commens streptococci addit demonstr ferionp detect pathogen biofilm natur teeth via facil colorimetr reaction find provid clinic evid theranost potenti catalyt nanoparticl target anti infect nanomedicin

D052203;D053758

T121;T073;T197

direct detect foodborn pathogen via proxim dna probe base crispr cas assay foodborn pathogen caus ill exist tool detect foodborn pathogen typic time consum requir complex protocol report assay direct analyz pathogen gene base crispr cas new test term proxim dna probe base crispr cas ppcas facilit detect foodborn pathogen without amplif step elimin nucleic acid amplif process dramat reduc process time complex cost analysi foodborn pathogen substitut frequent use dualli label dna report proxim dna probe ppcas assay led fold sensit enhanc ppcas offer limit detect coloni form unit detect salmonella enterica enterica without nucleic acid amplif process specif recognit gene via ppcas allow distinguish enterica foodborn pathogen ppcas assay appli screen enterica contamin fresh egg high precis henc new ppcas assay valuabl tool site monitor foodborn pathogen

D005517;D019779

T007;T037

residu specif kinet insight transit state slow polypeptid topolog isomer nmr exchang spectroscopi character transit state central issu biophys studi protein fold nmr multiprob measur techniqu provid residu specif inform use exchang spectroscopi character transit state two state slow topolog isomer residu lantibiot peptid exchang kinet rate vari per residu basi indic reduc kinet cooper two state exchang well previous observ reduc thermodynam cooper furthermor temperatur depend measur reveal larg variat activ enthalpi entropi term among residu interest found linear relationship logarithm equilibrium constant exchang rate data point deriv amino acid residu one polypeptid chain refer linear relationship residu base linear free energi relationship rblfer rblfer offer inform transit state two state exchang

D019906;D013816

T063;T090

allicin amelior intestin barrier damag via microbiota regul short chain fatti acid tlrmydnf b cascad respons acrylamid induc rat acrylamid aa heat induc toxic caus sever damag health present studi sd rat use investig potenti therapeut effect allicin dietari supplement rat aa induc intestin injuri elev express occludin claudin zonula occluden zo mucin mucin indic oral allicin allevi intestin epitheli barrier breakag induc aa compar aa treat group gut microbiota bacteroid escherichiashigella dubosiella alloprevotella relat synthesi short chain fatti acid scfas negat affect aa allicin regul cascad respons microbiota scfas signal revers reduct acet acid propion acid aa treatment allicin also dramat regul express toll like receptor tlr myeloid differenti factor myd nf b signal pathway protein proinflammatori cytokin promot product scfas aa treat rat allicin reliev intestin barrier injuri inflamm caus aa evidenc regul cascad respons microbiota scfas tlrmydnf b signal pathway conclus allicin high effect treatment prevent aa induc intestin injuri

D064307;D053594

T116;T129;T001;T032;T028

low frequenc spectra methyl octylimidazolium tetrafluorobor mixtur poli ethylen glycol femtosecond raman induc kerr effect spectroscopi first report low frequenc spectra ionic liquid il polym mixtur use femtosecond raman induc kerr effect spectroscopi studi mixtur methyl octylimidazolium tetrafluorobor moim bf poli ethylen glycol peg n peg various concentr elucid uniqu featur ilpolym mixtur system mixtur peg molecular liquid octhylimidazol oim neutral analog cation also studi addit mixtur moim bf ethylen glycol eg poli ethylen glycol n peg also investig first moment broad low frequenc spectra main due intermolecular vibrat moim bf peg oimpeg increas slight increas concentr peg indic microscop intermolecular interact general slight enhanc also compar moim bf mixtur eg peg peg concentr wt peg eg low frequenc spectra sampl concentr quit similar comparison normal spectra show spectral intens low frequenc region cm moim bf mixtur peg peg somewhat lower moim bf mixtur eg although effect polym small compar polym solut system featur attribut suppress translat motion mixtur moim bf peg compar mixtur moim bf eg due greater mass peg eg densiti surfac tension viscos electr conduct also estim walden plot found moim bf peg system show ideal electr conduct behavior moim bf peg moim bf eg system

D052578;D011092

T121;T109;T130;T103;T120

evid rate limit proton transfer n ar aminolysi acetonitril synthet relev condit earli synthet step synthesi adavosertib azd n ar reaction fluoronitrobenzen methylpiperazin acetonitril simpl kinet base design four reaction profil experi use investig kinet reaction purpos build kinet model fit reaction profil data two experi conduct c differ excess methylpiperazin show reaction follow third order rate law second order depend upon methylpiperazin ration term reaction follow rate limit proton transfer mechan base catalyz progress product driven proton transfer involv second molecul methylpiperazin experiment determin entropi activ j k consist mechan format low level impur found due presenc trace piperazin methylpiperazin shown react approxim time faster methylpiperazin c rate constant methylpiperazin catalyz reaction piperazin methylpiperazin piperazin deriv impur found correl brnsted type analysi p k acetonitril amin nucleophil

D000588;D011522

T196;T109

role impact high emiss high temperatur choos optim mitig target choos among emiss trajectori lead final expect temperatur c societi need weigh extra mitig cost strategi extra benefit addit reduc damag damag associ high emiss lead high temperatur play role calcul uncertainti link emiss temperatur high temperatur play role desir near term mitig general modest effect need focus scientif attent polici relev emiss path consequ pay much less attent happen high emiss scenario

D057231

T070