Information_extraction/task29_drug_dose_extraction.json

{
    "Contributors": [
        "Ishani Mondal"
    ],
    "Source": [
        "ade_corpus_v2"
    ],
    "URL": [
        "https://github.com/trunghlt/AdverseDrugReaction/tree/master/ADE-Corpus-V2"
    ],
    "Categories": [
        "Information Extraction"
    ],
    "Reasoning": [],
    "Definition": [
        "In this task, you will be given sentences and a drug name in which your task is to indicate the doses of intake of that particular drug. A dose refers to a specified amount of medication taken at one time. Although there might be several correct answers, you need to write one of them."
    ],
    "Input_language": [
        "English"
    ],
    "Output_language": [
        "English"
    ],
    "Instruction_language": [
        "English"
    ],
    "Domains": [
        "Clinical Knowledge",
        "Drug",
        "Academical Papers",
        "Healthcare"
    ],
    "Positive Examples": [
        {
            "input": "An episode of subacute encephalopathy after the infusion of methotrexate (1500 mg/m2) (MTX) is reported in a young adult with metastastic gastric cancer.\t methotrexate",
            "output": "1500 mg/m2",
            "explanation": "Here, the drug methotrexate mentioned after '\t ' has been mentioned to be taken as 1500 mg/m2 within brackets and hence should be tagged as dosage."
        },
        {
            "input": "A case of normotensive scleroderma renal crisis after high-dose methylprednisolone treatment.\t methylprednisolone",
            "output": "high",
            "explanation": "Amount of methylprednisolone is taken in high amount and hence should be tagged with that."
        }
    ],
    "Negative Examples": [
        {
            "input": "Ibuprofen overdose is usually characterized by GI upset, dizziness, and mild sedation\t ibuprofen",
            "output": "mild",
            "explanation": "Here the drug ibuprofen has been mentioned to be taken in excess but mild is the qualifier of the sedation caused by overdose of the drug, hence mild should not be tagged as drug dosage."
        },
        {
            "input": "She took three doses of methotrexate and two doses of ibuprofen.\t methotrexate",
            "output": "two",
            "explanation": "Amount of methotrexate is taken in three doses and hence should be tagged with that, instead of the the dosage mentioned for ibuprofen."
        }
    ],
    "Instances": [
        {
            "id": "task1451-4a32996c896e4ba4af9bb6cfb4628ce7",
            "input": "METHODS: Growth retardation was observed in six severely asthmatic children after introduction of high-dose fluticasone propionate treatment (dry powder).\t fluticasone propionate",
            "output": [
                "high"
            ]
        },
        {
            "id": "task1451-379dc9b35d49462c9722445d9c2f2649",
            "input": "Two case reports of bilateral granulomatous anterior uveitis are described in patients with open angle glaucoma treated with metripranolol 0.6% eye drops.\t metripranolol",
            "output": [
                "0.6"
            ]
        },
        {
            "id": "task1451-8264c178667641dbac8a59d7d5cf3af4",
            "input": "This case suggests that acyclovir when given intravenously in doses of 10 mg/kg may result in increased serum lithium concentrations.\t acyclovir",
            "output": [
                "10 mg/kg"
            ]
        },
        {
            "id": "task1451-3fe69c5ac6974445821bc19e3d99b957",
            "input": "This case suggests that acyclovir when given intravenously in doses of 10 mg/kg may result in increased serum lithium concentrations.\t lithium",
            "output": [
                "10 mg/kg"
            ]
        },
        {
            "id": "task1451-58de8f0c9a7c41a98d914e73b65a7092",
            "input": "We describe 2 patients with cutaneous lupus erythematosus who developed severe dapsone reaction after low dose therapy, with a fatal outcome in one.\t dapsone",
            "output": [
                "low"
            ]
        },
        {
            "id": "task1451-d84ef3cd7442478f9fb4bd123f83fc0e",
            "input": "A 17-year-old female patient who had been taking oral minocycline (50 mg twice daily) for 3 weeks for acne developed an eruption that progressed to an exfoliative dermatitis.\t minocycline",
            "output": [
                "50 mg twice daily"
            ]
        },
        {
            "id": "task1451-91e06a4b953148f1927f6aab52b281f1",
            "input": "Overdose of magnesium sulfate in combination with renal insufficiency, hypocalcemia, or compromise of intestinal integrity may predispose horses to magnesium toxicosis.\t magnesium",
            "output": [
                "Overdose"
            ]
        },
        {
            "id": "task1451-4452acb10e8f45d599299bcbe9fb52f9",
            "input": "Overdose of magnesium sulfate in combination with renal insufficiency, hypocalcemia, or compromise of intestinal integrity may predispose horses to magnesium toxicosis.\t magnesium sulfate",
            "output": [
                "Overdose"
            ]
        },
        {
            "id": "task1451-24ddea23892a4383825f3a0de39379e8",
            "input": "We thus concluded that an excessive dose of AZ had probably destroyed the gastric mucosal barrier or thrombocytopenia due to bone marrow disorder and thus eventually led to the development of hemorrhagic gastritis.\t AZ",
            "output": [
                "excessive"
            ]
        },
        {
            "id": "task1451-dbc58ce2ac684f3988b14a8ca41ecd2b",
            "input": "On the next day, after a total dose of only 600 mg of danazol, gingival bleeding and purpura occurred.\t danazol",
            "output": [
                "600 mg"
            ]
        },
        {
            "id": "task1451-264c8c79515645daa399c5fbe6116ec9",
            "input": "We reported 3 patients who developed acute generalized dystonia and akinetic rigid syndrome following an initial therapy with d-penicillamine 125-500 mg daily.\t d-penicillamine",
            "output": [
                "125-500 mg daily"
            ]
        },
        {
            "id": "task1451-6bac619b162247e88129e1ae1a6b663d",
            "input": "Ballistic movements due to ischemic infarcts after intravenous heroin overdose: report of two cases.\t heroin",
            "output": [
                "overdose"
            ]
        },
        {
            "id": "task1451-4129f9617c6141f2b4d32e63dc3bccec",
            "input": "Two heroin addicts, aged 34 and 19 years, developed ballistic movements after intravenous heroin overdose.\t heroin",
            "output": [
                "overdose"
            ]
        },
        {
            "id": "task1451-7d660f0a50b7419391d8fb207e5277bc",
            "input": "We report a 76-year-old man who developed an acute blistering eruption following high-dose penicillin treatment for pneumococcal septicaemia.\t penicillin",
            "output": [
                "high"
            ]
        },
        {
            "id": "task1451-d6c36849063c4dc8904a5bfb5f1882dd",
            "input": "In case 1, a total daily dose of 25 mg sertraline, with nondetectable sertraline and desmethylsertraline blood levels, resulted in a doubling of the lamotrigine blood level with symptoms of toxicity.\t desmethylsertraline",
            "output": [
                "25 mg"
            ]
        },
        {
            "id": "task1451-07560d07eae343728fa11a31574137b2",
            "input": "In case 1, a total daily dose of 25 mg sertraline, with nondetectable sertraline and desmethylsertraline blood levels, resulted in a doubling of the lamotrigine blood level with symptoms of toxicity.\t lamotrigine",
            "output": [
                "25 mg"
            ]
        },
        {
            "id": "task1451-016380dbada7461193068a44a8786e8e",
            "input": "We report a case of pancytopenia in a 23-year-old man with Crohn's disease who was treated with 5-aminosalicylic acid (Pentasa; Nisshin, Tokyo, Japan) 3.0 g/day.\t 5-aminosalicylic acid",
            "output": [
                "3.0 g/day"
            ]
        },
        {
            "id": "task1451-c4b2a8dc1f29437291ab2a1c13fd7826",
            "input": "We report a case of pancytopenia in a 23-year-old man with Crohn's disease who was treated with 5-aminosalicylic acid (Pentasa; Nisshin, Tokyo, Japan) 3.0 g/day.\t Pentasa",
            "output": [
                "3.0 g/day"
            ]
        },
        {
            "id": "task1451-ffc8a60083354d3b8dc3488744ded11c",
            "input": "1. Changes in the plasma cortisol level were reported in a male patient with panic disorder during the period of low-dose alprazolam treatment (mean 0.62 +/- 0.15 mg/day) compared with during the period of high-dose period (mean 1.08 +/- 0.28 mg/day).\t alprazolam",
            "output": [
                "low"
            ]
        },
        {
            "id": "task1451-e61b0a4e61c44deda1a3cbcbf0eaa8bd",
            "input": "We report on three patients with acute schizophrenia, who developed severe akathisia during treatment with olanzapine (20-25 mg/d).\t olanzapine",
            "output": [
                "20-25 mg/d"
            ]
        },
        {
            "id": "task1451-5c9e9c67600f4dbe8df63b116cb32d1f",
            "input": "A 65-year-old woman with angina pectoris presented with syncope after sublingual ingestion of isosorbide dinitrate (5 mg).\t isosorbide dinitrate",
            "output": [
                "5 mg"
            ]
        },
        {
            "id": "task1451-aec3411cd2c048e5a09d907bf90635e5",
            "input": "In a postural challenge test after administration of isosorbide dinitrate (5 mg), blood pressure decreased from 120/67 to 65/35 mmHg, followed by syncope with a sudden decrease in pulse rate from 85 to 60 beats/min.\t isosorbide dinitrate",
            "output": [
                "5 mg"
            ]
        },
        {
            "id": "task1451-92a7576e81a14e4e9f3bfd78ae7bb175",
            "input": "High-dose phosphate treatment leads to hypokalemia in hypophosphatemic osteomalacia.\t phosphate",
            "output": [
                "High"
            ]
        }
    ],
    "Instance License": [
        "Unknown"
    ]
}