Abstract: Six trials with a combined total of 885 patients were included in this review. Only studies using prosthetic PTFE grafts were identified. Two trials compared PTFE graft with or without a vein cuff. In one underpowered trial for below knee bypass the cumulative primary patency rate was statistically significantly higher in the vein cuff group (80.3% versus 65.3% at 12 months and 51.8% versus 29.1% at 24 months, P = 0.03). There was no statistically significant difference in secondary patency (82.9% versus 72.5% and 58.6% versus 34.9%, P = 0.14) and limb salvage rates (86.3% versus 71.8% and 82.6% versus 62.2%, P = 0.08) at 12 and 24 months respectively. The other trial showed no statistically significant difference between the groups at three years in the below knee femoro-popliteal bypasses (primary patency rate 26% (95% confidence interval (CI) 18 to 38) and 43% (95% CI 33 to 58), secondary patency rate 32% (95% CI 23 to 44) and 42% (95% CI 31 to 56) and limb salvage rate 64% (95% CI 54 to 75) and 61% (95% CI 50 to 74) in the collar and no collar groups respectively). In the femoro-distal bypass group, the differences in primary patency, secondary patency and limb salvage rates were also not statistically significant at three years (primary patency rate 20% (95% CI 11 to 38) and 17% (95% CI 9 to 33), secondary patency rate 22% (95% CI 12 to 39) and 20% (95% CI 11 to 35) and limb salvage rate 59% (95% CI 46 to 76) and 44% (95% CI 32 to 61) in the collar and no collar groups respectively). One trial compared pre-cuffed PTFE grafts with vein cuffed grafts. There was no statistically significant difference in primary patency rate (62% pre-cuffed PTFE versus 52% vein cuff PTFE and 49% versus 44%, P = 0.53), secondary patency rate (66% pre-cuffed PTFE versus 53% vein cuff PTFE and 55% versus 50%, P = 0.30) or limb salvage rate (75% pre-cuffed PTFE versus 72% vein cuff PTFE and 62% versus 65%, P = 0.88) at 12 and 24 months respectively. One trial compared spliced vein grafts with vein cuffed PTFE grafts. At 24 months, the secondary patency rate was statistically significantly higher in the spliced vein group (86% in the spliced vein and 52% in the vein cuff group, P < 0.05). There was no statistical significant difference in primary patency rate (44% versus 50%, P > 0.05) and limb salvage rate (94% versus 85%, P > 0.05). Two trials compared vein cuff PTFE grafts with and without AVF. There was no statistical significant difference at 24 months in primary patency rate (29% versus 36%, P = 0.77; 32% versus 28%, P = 0.2), secondary patency rate (40% versus 40%, P = 0.89; 28% versus 24%, P = 0.2) and limb salvage rate (65% versus 70%, P = 0.97; 62% versus 71%, P = 0.3). There is some evidence that a vein cuff at the distal anastomosis site improves primary graft patency rates for below knee PTFE graft, but this does not reduce the risk of limb loss. Evidence for this beneficial effect of vein cuffed PTFE grafts is weak and based on an underpowered trial. Pre-cuffed PTFE grafts have comparable patency and limb salvage rates to vein cuff PTFE grafts. The use of spliced veins improved secondary patency but this did not translate into improved limb salvage. The use of an AVF alone showed no added benefits. A large study with a specific focus on below knee vein cuff prosthetic grafts, including PTFE, is required.

Plain-language summary: This review looked at six trials, with a combined total of 885 patients, which compared different methods of making these grafts. Results from two trials which looked at the effect of inserting a cuff of vein at the lower end of the synthetic graft before attaching it to the artery below the knee are conflicting. With one study showing that the bypass graft remains functional for a longer period of time and in the other study no benefit was seen. If a synthetic graft is made in a fashion imitating the shape of a vein cuff, then the same benefit can be achieved. The results also show that when short lengths of vein are joined together to form a sufficiently long graft, the bypass works for longer, although this does not result in fewer amputations. Finally, there is no added benefit for graft patency or amputation rate if a connection is made between the artery and the vein (fistula) when constructing a vein cuff with the synthetic graft but the operation takes longer.