Claim: UV excision repair protein RAD23B is a protein that contains an N-terminal ubiquitin-like domain, encoded by the RAD23B gene and is the initial damage recognition factor in  global genomic nucleotide excision repair as well as the assembly of the other core NER factors
Evidence: UV excision repair protein RAD23 homolog B is a protein that in humans is encoded by the RAD23B gene. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells. The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair (NER). The complex of XPC-RAD23B is the initial damage recognition factor in global genomic nucleotide excision repair (GG-NER). The presence of XPC-RAD23B is required for assembly of the other core NER factors and progression through the NER pathway both in vitro and in vivo.