Claim: Bladder cancer, the most common type being transitional cell carcinoma, has an increased risk if both copies of the GSTM1 gene are deleted or their are mutations in NAT2.
Evidence: The most common type is transitional cell carcinoma. Deletion of both copies of the GSTM1 gene has a modest increase in risk of bladder cancer. Similarly, mutations in NAT2 (N-acetyltransferase) is associated with increased risk for bladder cancer.