Claim: The Hexose oxidase (of the family oxidoreductases) has two substrates called D-glucose and O2.
Evidence: This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with oxygen as acceptor. Thus, the two substrates of this enzyme are D-glucose and O2, whereas its two products are D-glucono-1,5-lactone and H2O2.