Claim: TNNT2 which encodes the cardiac muscle troponin T functions as part of the Troponin complex with its C-terminal region of TNT apart of the globular troponin complex domain.
Evidence: The TNNT2 gene is located at 1q32 in the human chromosomal genome, encoding the cardiac muscle isoform of troponin T (cTnT). As part of the Troponin complex, the function of cTnT is to regulate muscle contraction. The C-terminal region of TnT constitutes part of the globular troponin complex domain, and participates in employing the calcium sensitivity of strong myosin crossbridge binding to the thin filament.