Claim: Lymphotoxin-alpha, or tumor necrosis factor-beta protein, must bind with a complex with LT-β to form the LT-α1-β2 complex, thereby enabling binding to LT-β receptors to activate signaling pathways, finally leading to cellular fates.
Evidence: Lymphotoxin-alpha (LT-α) or tumor necrosis factor-beta (TNF-β) is a protein that in humans is encoded by the LTA gene. In order for activation to occur, LT-α must form a complex with LT-β to form the LT-α1-β2 complex. Formation of LT-α1-β2 complex enables binding to LT-β receptors and subsequent activation of signaling pathways. Activation of signaling pathways such as NF-κB ultimately leads to various cellular fates, including cell proliferation and cell death.