Claim: CUL4A (belongs to the cullin family) is falsely believed to occur at the offset of DNA replication UV irradiation also induces CRL4A-mediated destruction
Evidence: During unperturbed cell cycle progression, ubiquitination and downregulation of these proteins by CRL4A occurs at the onset of DNA replication. DNA damage such as UV irradiation also induces CRL4A-mediated destruction of those proteins. CUL4A belongs to the cullin family of ubiquitin ligase proteins and is highly homologous to the CUL4B protein.