Claim: Neuropilin 2 is a protein (chains of amino acid residues) expressed by a wide variety of cell types, promotes downstream signaling pathways and plays a role in cardiovascular development.
Evidence: Neuropilin 2 (NRP2) is a protein that in humans is encoded by the NRP2 gene. Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues. NRP2 is expressed by a wide variety of cell types. The transmembrane protein has been reported to bind to SEMA3C, SEMA3F, VEGF-A, VEGF-C, VEGF-D, TGFβ, integrins and ANGPTL4 to promote downstream signaling pathways. Consequently, NRP2 is known to play a role in cardiovascular development, axon guidance, tumorigenesis, inflammation and cardiovascular disease.