Claim: Deficiency of TCF2 (transcription factor 2) cause abnormal maternal-Zygote transition and early embryogenesis failure and mutation of TCF2 that disrupts normal function has been identified as the cause of MODY5 (Maturity-Onset of Diabetes, Type 5).
Evidence: HNF1 homeobox B (hepatocyte nuclear factor 1 homeobox B), also known as HNF1B or transcription factor 2 (TCF2), is a human gene. Deficiency of TCF2 cause abnormal maternal-Zygote transition and early embryogenesis failure. Mutation of TCF2 that disrupts normal function has been identified as the cause of MODY5 (Maturity-Onset of Diabetes, Type 5).