Claim: BARD1 and BRCA1 form a heterodimer via their N-terminal RING finger domains that could be observed in vivo and in vitro.
Evidence: BARD1 and BRCA1 form a heterodimer via their N-terminal RING finger domains. The BARD1-BRCA1 interaction is observed in vivo and in vitro and is essential for BRCA1 stability.