Claim: A pseudogene has been identified for ID2, a protein that may play a role in negatively regulating cell differentiation by inhibiting the function of basic helix-loop-helix transcription factor by suppressing their heterodimerization partners through HLH domains.
Evidence: DNA-binding protein inhibitor ID-2 is a protein that in humans is encoded by the ID2 gene. This protein may play a role in negatively regulating cell differentiation. A pseudogene has been identified for this gene. The protein encoded by this gene belongs to the inhibitor of DNA binding (ID) family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the ID family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains.