Claim: Chymase, a chymotryptic serine proteinase that belongs to the peptidase family S1, is an enzyme that in humans is encoded by the CMA1 gene and is unsuitable for cardiovascular disease therapies.
Evidence: Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies.