Claim: The nuclear pore complex (NPC) is made up of approximately thirty different proteins known as nucleoporins and produced via a biogenesis pathway that includes the synthesis and proteolytic cleavage of an 186 kD precursor protein.
Evidence: The 98 kD nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kD precursor protein. Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is composed of approximately 30 unique proteins collectively known as nucleoporins.