Claim: PSMD12 proteasome forms a pivotal component for the ubiquitin-proteasome system, and its study provides a comprehensive understanding for clinical applications including understanding specific diseases, targeting therapeutic interventions, and developing diagnostic markers and strategies.
Evidence: More recently, more effort has been made to consider the proteasome for the development of novel diagnostic markers and strategies. The proteasome and its subunits are of clinical significance for at least two reasons: (1) a compromised complex assembly or a dysfunctional proteasome can be associated with the underlying pathophysiology of specific diseases, and (2) they can be exploited as drug targets for therapeutic interventions. The proteasomes form a pivotal component for the ubiquitin–proteasome system (UPS) and corresponding cellular Protein Quality Control (PQC).