Claim: BUB1B plays a role in the inhibition of the anaphase-promoting complex cyclosome slowing the onset of cancer, interacting with BRCA2.
Evidence: The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. BRCA2