Claim: TIMP1, which is a tissue inhibitor of metalloproteinases belonging to the TIMP family, is an inhibitory molecule which plays a role in implantation during pregnancy.
Evidence: TIMP metallopeptidase inhibitor 1, also known as TIMP1, a tissue inhibitor of metalloproteinases, is a glycoprotein that is expressed from the several tissues of organisms. TIMP1 is an inhibitory molecule that regulates matrix metalloproteinases (MMPs), and disintegrin-metalloproteinases (ADAMs and ADAMTSs). This protein is a member of the TIMP family. In pregnancy, TIMP1 plays a regulatory role in the process of implantation, particularly the cytotrophoblast invasion of the uterine endometrium.