Claim: ERCC1–XPF, a structure-specific endonuclease, participates in DNA repair and DNA recombination; but does not cut DNA that is exclusively single-stranded or double-stranded.
Evidence: The ERCC1–XPF complex is a structure-specific endonuclease. Together with ERCC1, ERCC4 forms the ERCC1-XPF enzyme complex that participates in DNA repair and DNA recombination. ERCC1-XPF does not cut DNA that is exclusively single-stranded or double-stranded, but it cleaves the DNA phosphodiester backbone specifically at junctions between double-stranded and single-stranded DNA.