Claim: Core-binding factor subunit beta, or CBFB, encodes a distinct carboxyl terminus and is associated with acute myeloid leukemia.
Evidence: Core-binding factor subunit beta is a protein that in humans is encoded by the CBFB gene. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype.