Claim: The PSMD12 gene (a sequence of neocleotides in DNA or RNA that enclode syntheses of RNA or protein) froms a pivotal component for the ubiquitin-proteasome system, but its usefulness has not been studied for understanding specific diseases or therapies.
Evidence: The proteasome and its subunits are of clinical significance for at least two reasons: (1) a compromised complex assembly or a dysfunctional proteasome can be associated with the underlying pathophysiology of specific diseases, and (2) they can be exploited as drug targets for therapeutic interventions.