Claim: G1/S-specific cyclin-E1 is a protein that in humans is encoded by the CCNE1 gene; overexpression of this gene has been observed in many tumors, which results in chromosome instability, and may contribute to tumorigenesis..
Evidence: G1/S-specific cyclin-E1 is a protein that in humans is encoded by the CCNE1 gene. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis.