Claim: Isoforms encoded by BIN1, expressed in the central nervous system, may be involved in synaptic vesicle endocytosis; while isoforms, expressed in muscle, localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process.
Evidence: This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynanim, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process.