Claim: HMGA1 preferentially binds to the minor groove of AT-rich regions and has little secondary structure in solution
Evidence: High-mobility group protein HMG-I/HMG-Y is a protein that in humans is encoded by the HMGA1 gene. HMGA1 preferentially binds to the minor groove of AT-rich regions in double-stranded DNA using its AT-hooks. It has little secondary structure in solution but assumes distinct conformations when bound to substrates such as DNA or other proteins.