Claim: BMI1 has been reported an an oncogene by regulating cell cycle inhibitors; BMI1 is rapidly recruited to sites of DNA damage; lackfof BMI1 in mice results in developmental defects.
Evidence: BMI1 (B lymphoma Mo-MLV insertion region 1 homolog) has been reported as an oncogene by regulating p16 and p19, which are cell cycle inhibitor genes. Recently it has been reported BMI1 is rapidly recruited to sites of DNA damage and it sustains for over 8h. Bmi1 knockout in mice results in defects in hematopoiesis, skeletal patterning, neurological functions, and development of the cerebellum.