Claim: SOCS3, a gene that encodes a member of the STAT-induced STAT inhibitor or SSI, binds with cytokine receptors, including IL6, IL10, and interferon (IFN)-gamma, to make the inhibitory function of the gene work.
Evidence: This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. For signaling of IL-6, Epo, GCSF and Leptin, binding of SOCS3 to the respective cytokine receptor has been found to be crucial for the inhibitory function of SOCS3. The expression of SOCS3 gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma.