Claim: Emanuel syndrome is caused by inheriting the der(22) chromosome which causes multiple congenital anomalies.
Evidence: Emanuel syndrome, also known as derivative 22 syndrome, or der(22) syndrome, is a rare disorder associated with multiple congenital anomalies, including profound intellectual disability, preauricular skin tags or pits, and conotruncal heart defects. It can occur in offspring of carriers of the constitutional chromosomal translocation t(11;22)(q23;q11), owing to a 3:1 meiotic malsegregation event resulting in partial trisomy of chromosomes 11 and 22. Emanuel syndrome is an inherited chromosome abnormality. People with Emanuel syndrome typically inherit the der(22) chromosome from an unaffected parent.