Claim: In humans, two ubiquitous plastin isoforms have been identified; namely, L, expressed in hemopoietic cell lineages and many types of malignant human cells of non-hemopoietic origin, and T, found in all other normal cells of solid tissues that have replicative potential.
Evidence: In humans, two ubiquitous plastin isoforms (L and T) have been identified. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues.