Claim: SOX2, or the SRY-box 2, binds to DNA cooperatively with Oct4 at non-palindromic sequences but the regulation of Oct4-Sox2 enhancers can occur without Sox2.
Evidence: SRY (sex determining region Y)-box 2, also known as SOX2, is a transcription factor that is essential for maintaining self-renewal, or pluripotency, of undifferentiated embryonic stem cells. Sox2 binds to DNA cooperatively with Oct4 at non-palindromic sequences to activate transcription of key pluripotency factors. Surprisingly, regulation of Oct4-Sox2 enhancers can occur without Sox2, likely due to expression of other Sox proteins.