Claim: Disabled homolog 2 is a protein (nutrient) which expressed in normal ovarian epithelial cells but is down-regulated or absent from ovarian carcinoma cell lines and the down-regulation of DAB2 may play an important role in ovarian carcinogenesis.
Evidence: Disabled homolog 2 is a protein that in humans is encoded by the DAB2 gene. Proteins are essential nutrients for the human body. DAB2 mRNA is expressed in normal ovarian epithelial cells but is down-regulated or absent from ovarian carcinoma cell lines. The down-regulation of DAB2 may play an important role in ovarian carcinogenesis.