Claim: S100A4 which is a member of the S100 calcium-binding protein(a family of low-molecular-weight proteins found in vertebrates and characterized by two calcium-binding sites) family supports tumorigenesis by stimulating angiogenesis and conversely, silencing it by shRNA technology shows a dramatic decrease in tumor development of the pancreatic MIA PaCa-2 cell line.
Evidence: S100A4, a member of the S100 calcium-binding protein family secreted by tumor and stromal cells, supports tumorigenesis by stimulating angiogenesis. The S100 proteins are a family of low-molecular-weight proteins found in vertebrates and characterized by two calcium-binding sites that have helix-loop-helix ("EF-hand type") conformation. Conversely, when silencing S100A4 by shRNA technology, a dramatic decrease in tumor development of the pancreatic MIA PaCa-2 cell line was observed.