Claim: COPS6 gene encodes COP9 signalosome protein that functions as a positive regulator of E3 ubiquitin ligases.
Evidence: The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases.