Claim: Neuropilin 2 is expressed by a wide variety of cell types, promotes downstream signaling pathways but has no role in vital organ development.
Evidence: Neuropilin 2 (NRP2) is a protein that in humans is encoded by the NRP2 gene. The transmembrane protein has been reported to bind to SEMA3C, SEMA3F, VEGF-A, VEGF-C, VEGF-D, TGFβ, integrins and ANGPTL4 to promote downstream signaling pathways. Consequently, NRP2 is known to play a role in cardiovascular development, axon guidance, tumorigenesis, inflammation and cardiovascular disease. The circulatory system, also called the cardiovascular system or the vascular system, is an organ system that permits blood to circulate and transport nutrients (such as amino acids and electrolytes), oxygen, carbon dioxide, hormones, and blood cells to and from the cells in the body to provide nourishment and help in fighting diseases, stabilize temperature and pH, and maintain homeostasis.