Claim: The longest first lady of Syria is Anisa Makhlouf (29 years), followed by the second-longest first lady Asma al-Assad, (21 years), who is the wife of Bashar Hafez al-Assad (the 19th president of Syria since July 17, 2000, and the son of Hafez al-Assad, the 18th president of Syria, serving from 1971 to 2000.).
Evidence: Anisa (or Aniseh) Makhlouf (Arabic: أنيسة مخلوف‎; 1930 – 6 February 2016) was the Syrian matriarch of the Al-Assad family, which has ruled the country since 1971. The wife of the late President Hafez al-Assad, Makhlouf held the position of First Lady of Syria from 1971 until 2000. Asma Fawaz al-Assad (Arabic: أَسْمَاء الْأَسَد‎, romanized: ʾAsmāʾ al-ʾAsad, Levantine pronunciation: [asˈmaː elˈasad; née Akhras, Arabic: أَسْمَاء فَوَّاز الْأَخْرَس‎, romanized: ʾAsmāʾ Fawwāz al-ʾAḵras: [ˈasma fawˈwaːz elˈʔax.ras; born 11 August 1975) is the First Lady of Syria. Asma moved to Syria in November 2000 and married Bashar in December of that year. Hafez al-Assad (Arabic: حَافِظ الْأَسَد‎ Ḥāfiẓ al-ʾAsad, Levantine Arabic: [ˈħaːfezˤ elˈʔasad, Modern Standard Arabic: [ħaːfɪðˤ al'ʔasad; 6 October 1930 – 10 June 2000) was a Syrian politician who served as the President of Syria from 1971 to 2000. Bashar al-Assad Bashar Hafez al-Assad (Arabic: بَشَّار حَافِظ الْأَسَد‎‎, Baššār Ḥāfiẓ al-ʾAsad, Levantine pronunciation: [baʃˈʃaːr ˈħaːfezˤ elˈʔasad; English pronunciation (help·); born 11 September 1965) is a Syrian politician who has been the 19th president of Syria since 17 July 2000. British
Syrian Bashar al-Assad ​
​(m. 2000)​