Claim: RBBP4 is present in protein complexes that has been implicated in chromatin remodeling which is an integral component of transcriptional silencing and is a possible therapeutic approach to restore age-related memory loss.
Evidence: It is part of the Mi-2/NuRD complex that has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of corepressor complexes, which is an integral component of transcriptional silencing. RBBP4 works at least in part through the PKA-CREB1-CPB pathway. Hence one possible therapeutic approach to restore age-related memory loss is the use of PKA-CREB1-CPB pathway stimulating drugs.