Claim: Lymphotoxin-alpha must bind with a complex with LT-β to form the LT-α1-β2 complex, thereby enabling binding to LT-β receptors to activate signaling pathways, finally leading to cellular fates.
Evidence: In order for activation to occur, LT-α must form a complex with LT-β to form the LT-α1-β2 complex. Formation of LT-α1-β2 complex enables binding to LT-β receptors and subsequent activation of signaling pathways. Activation of signaling pathways such as NF-κB ultimately leads to various cellular fates, including cell proliferation and cell death.