Claim: TRAF1 is a protein that is encoded by the TRAF1 gene, (or sequence of nucleotides in DNA or RNA that encodes the synthesis of gene product). which can interact with TRAF2 and IAP and mediate the anti-apoptolic signals from TNF receptors, which interaction is thought to link LMP1 mediated B lyumphocyte transformation to signal transduction from the TNFR family receptors.
Evidence: TNF receptor-associated factor 1 is a protein that in humans is encoded by the TRAF1 gene. The protein complex formed by this protein and TRAF2 also interacts with IAP, and thus mediates the anti-apoptotic signals from TNF receptors. EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). In biology, a gene is a sequence of nucleotides in DNA or RNA that encodes the synthesis of a gene product, either RNA or protein.