Claim: The nuclear pore complex (NPC) is made up of approximately thirty different proteins known as nucleoporins, one of which is the 98 kD which is produced via a biogenesis pathway that includes the synthesis and proteolytic cleavage of an 186 kD precursor protein.
Evidence: The proteins that make up the nuclear pore complex are known as nucleoporins; each NPC contains at least 456 individual protein molecules and is composed of 34 distinct nucleoporin proteins.About half of the nucleoporins typically contain solenoid protein domains—either an alpha solenoid or a beta-propeller fold, or in some cases both as separate structural domains.