Claim: Preimplantation genetic diagnosis is recently applied to diagnose late-onset diseases and predisposition syndromes, however,  in predisposition syndromes outcomes are unclear.
Evidence: A more recent application of PGD is to diagnose late-onset diseases and (cancer) predisposition syndromes. For example, in predisposition syndromes, such as BRCA mutations which predispose the individual to breast cancer, the outcomes are unclear.