Claim: Sam68 not only regulates the alternatve splicing of a number of cancer-related genes, but also interacts with splicing complex proteins KHDRBS3 (T-STAR) and Metadherin (involved in HIF-1alpha mediated angiogenesis), which also alter CD44 splicing.
Evidence: Sam68 regulates the alternatve splicing of a number of cancer-related genes. In prostate cancer, Sam68 also interacts with splicing complex proteins KHDRBS3 (T-STAR) and Metadherin (MTDH) which also alter CD44 splicing. MTDH (AEG-1) is involved in HIF-1alpha mediated angiogenesis.