Claim: Fresolimumab is a human monoclonal antibody made by cloning a unique white blood cell, with all subsequent antibodies derived from it tracing back to the unique parent cell; it has a target of TGF Beta one, two and three.
Evidence: Fresolimumab (GC1008) is a human monoclonal antibody and an immunomodulator. A monoclonal antibody (mAb or moAb) is an antibody made by cloning a unique white blood cell. All subsequent antibodies derived this way trace back to a unique parent cell. Fresolimumab Whole antibody Human TGF beta 1, 2 and 3 Transforming growth factor beta (TGF-β) is a multifunctional cytokine belonging to the transforming growth factor superfamily that includes three different mammalian isoforms (TGF-β 1 to 3, HGNC symbols TGFB1, TGFB2, TGFB3) and many other signaling proteins. Activated TGF-β complexes with other factors to form a serine/threonine kinase complex that binds to TGF-β receptors. TGFB proteins are produced by all white blood cell lineages.