Claim: ICAM3 transmembrane glycoproteins proteins bind to leukocyte adhesion adhesion LFA-1 proteins, but have no involvement in the initiation of immune response.
Evidence: All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leukocytes and may be the most important ligand for LFA-1 in the initiation of the immune response.