Claim: Isoforms encoded by BIN1 (also known as Bridging Integrator-1 and Amphiphysin-2), expressed in the central nervous system, may be involved in synaptic vesicle endocytosis; while isoforms, expressed in muscle, localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process.
Evidence: Myc box-dependent-interacting protein 1, also known as Bridging Integrator-1 and Amphiphysin-2 is a protein that in humans is encoded by the BIN1 gene. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynanim, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process.