Claim: RELB, sequestered by the NF-κB precursor protein p100 in the cytoplasm, appears in the nucleus with p70 and activates the expression homeostatic lymphokines.
Evidence: In this pathway, NIK stimulates the processing of p100 into p52, which in association with RelB appears in the nucleus as RelB:p52 NF-κB heterodimers. RelB:p52 activates the expression homeostatic lymphokines, which instruct lymphoid organogenesis and determine the trafficking of naive lymphocytes in the secondary lymphoid organs.