Druvith/transformed_medDataset huggingface dataset:
What to do for Kidney Dysplasia ? 
 - Kidney dysplasia is a condition in which the internal structures of one or both of a fetus kidneys do not develop normally while in the womb.  - Genetic factors can cause kidney dysplasia.  - Genetic syndromes that affect multiple body systems can also cause kidney dysplasia.  - A baby may also develop kidney dysplasia if his or her mother takes certain prescription medications during pregnancy, such as some used to treat seizures and high blood pressure.  - Many babies with kidney dysplasia in only one kidney have no signs of the condition.  - Health care providers may be able to diagnose kidney dysplasia during a womans pregnancy using a fetal ultrasound, also called a fetal sonogram.  - Health care providers do not always diagnose kidney dysplasia before a baby is born.  - If the condition is limited to one kidney and the baby has no signs of kidney dysplasia, no treatment may be necessary.  - Researchers have not found a way to prevent kidney dysplasia caused by genetic factors or certain genetic syndromes.  - Pregnant women can prevent kidney dysplasia by avoiding the use of certain prescription medications or illegal drugs during pregnancy.  - The long-term outlook for a child with kidney dysplasia in only one kidney is generally good.  - The long-term outlook for a child with kidney dysplasia in both kidneys is different from the long-term outlook for a child with one dysplastic kidney. A child with kidney dysplasia in both kidneys      - is more likely to develop chronic kidney disease (CKD)    - needs close follow-up with a pediatric nephrologist    - may eventually need dialysis or a kidney transplant
What is (are) What I need to know about Kidney Stones ? 
 A kidney* stone is a solid piece of material that forms in a kidney when there are high levels of certain substances in the urine. These substances are normally found in the urine and do not cause problems at lower levels.
                
A stone may stay in the kidney or travel down the urinary tract. Kidney stones vary in size. A small stone may pass on its own, causing little or no pain. A larger stone may get stuck along the urinary tract. A stone that gets stuck can block the flow of urine, causing severe pain or bleeding.
                
*See the Pronunciation Guide for tips on how to say the words in bold.
What is (are) What I need to know about Kidney Stones ? 
 The urinary tract is the bodys drainage system for removing wastes and extra water. The urinary tract includes two kidneys, two ureters, a bladder, and a urethra. The kidneys are two bean-shaped organs, each about the size of a fist. They are located near the middle of the back, just below the rib cage, one on each side of the spine. Every day, the two kidneys process about 200 quarts of blood to produce about 1 to 2 quarts of urine, composed of wastes and extra water. The urine flows from the kidneys to the bladder through tubes called ureters.
                
The bladder stores urine until releasing it through urination. When the bladder empties, urine flows out of the body through a tube called the urethra at the bottom of the bladder.
What causes What I need to know about Kidney Stones ? 
 Kidney stones are caused by high levels of calcium, oxalate, and phosphorus in the urine. Some foods may cause kidney stones in certain people. You may be more likely to get a kidney stone if you have
                
- a condition that affects levels of substances in your urine that can cause stones to form  - a family history of kidney stones  - repeating, or recurrent, urinary tract infections  - blockage of your urinary tract  - digestive problems
                
You may also be more likely to get a kidney stone if you dont drink enough fluids or if you take certain medicines.
What is (are) What I need to know about Kidney Stones ? 
 Doctors have found four main types of kidney stones:
                
- The most common types of stones contain calcium. Calcium is a normal part of a healthy diet. Calcium that is not used by the bones and muscles goes to the kidneys. In most people, the kidneys flush out the extra calcium with the rest of the urine. People who have calcium stones keep the calcium in their kidneys. The calcium that stays behind joins with other waste products to form a stone. People can have calcium oxalate and calcium phosphate stones. Calcium oxalate stones are more common.  - A uric acid stone may form when the urine contains too much acid. People who eat a lot of meat, fish, and shellfish may get uric acid stones.  - A struvite stone may form after you have a kidney infection.  - Cystine stones result from a genetic disorder, meaning a problem passed from parent to child. The disorder causes cystine to leak through the kidneys and into the urine.
What are the symptoms of What I need to know about Kidney Stones ? 
 You may have a kidney stone if you
                
- have pain while urinating  - see blood in your urine  - feel a sharp pain in your back or lower abdomenthe area between your chest and hips
                
The pain may last for a short or long time. You may have nausea and vomiting with the pain.
                
If you have a small stone that passes on its own easily, you may not have symptoms at all.
How to diagnose What I need to know about Kidney Stones ? 
 To diagnose kidney stones, your doctor will do a physical exam and ask about your medical history. The doctor may ask if you have a family history of kidney stones and about your diet, digestive problems, and other health problems. The doctor may perform urine, blood, and imaging tests to complete the diagnosis.
                
- Urine tests can show whether you have an infection or your urine contains substances that form stones.  - Blood tests can show problems that lead to kidney stones.  - Imaging tests are used to find the location of kidney stones in your body. The tests may also be able to show problems that caused a kidney stone to form.
What are the treatments for What I need to know about Kidney Stones ? 
 The treatment for kidney stones usually depends on their size and what they are made of. Kidney stones may be treated by your regular doctor or by a urologista doctor who specializes in the urinary tract. You may need treatment if you have symptoms or if a kidney stone is blocking your urinary tract. Small stones dont usually need treatment. Still, you may need pain medicine. You should also drink lots of fluids to help move the stone along. If you are vomiting often or dont drink enough fluids, you may need to go to the hospital and get fluids through a needle in your arm.
                
If you have a large kidney stone or your urinary tract is blocked, the urologist can remove the stone or break it into small pieces with the following treatments:
How to prevent What I need to know about Kidney Stones ? 
 To prevent kidney stones, you need to know what caused your kidney stone. Your doctor may ask you to try to catch the kidney stone as it passes in your urine. The kidney stone can then be sent to a lab to find out what type of stone it is. If you have treatment in the hospital and the doctor removes the stone, it will also be sent to a lab for testing.
                
Your doctor may ask you to collect your urine for 24 hours after the stone has passed or been removed. Your doctor can then measure how much urine you produce in a day and mineral levels in the urine. You are more likely to form stones if you dont make enough urine each day or have a problem with mineral levels.
                
Once you know what type of kidney stone you had, you can make changes in your eating, diet, and nutrition and take medicines to prevent future kidney stones.
What to do for What I need to know about Kidney Stones ? 
 You can help prevent kidney stones by making changes in how much you consume of the following:
                
- fluids  - sodium  - animal protein  - calcium  - oxalate
                
Drinking enough fluids each day is the best way to help prevent most types of kidney stones. You should drink 2 to 3 liters of fluid a day. If you had cystine stones, you may need to drink even more.
                
Though water is best, other fluids may also help prevent kidney stones, such as orange juice or lemonade. Talk with your health care provider if you cant drink the recommended amount due to other health problems, such as urinary incontinence, urinary frequency, or kidney failure.
                
You can make the following changes to your diet based on the type of kidney stone you had:
                
Calcium Oxalate Stones
                
- reduce sodium  - reduce animal protein, such as meat, eggs, and fish  - get enough calcium from food or take calcium supplements with food  - avoid foods high in oxalate, such as spinach, rhubarb, nuts, and wheat bran
                
Calcium Phosphate Stones
                
- reduce sodium  - reduce animal protein  - get enough calcium from food or take calcium supplements with food
                
Uric Acid Stones
                
- limit animal protein
                
More information about how changes in diet affect kidney stone formation is provided in the NIDDK health topic, Diet for Kidney Stone Prevention.
                

                
Medicines
                
Your doctor may prescribe medicines based on the type of kidney stone you had and any health problems you have that make you more likely to form a stone.
What to do for What I need to know about Kidney Stones ? 
 - A kidney stone is a solid piece of material that forms in a kidney when there are high levels of certain substances in the urine. These substances are normally found in the urine and do not cause problems at lower levels.  - Kidney stones are caused by high levels of calcium, oxalate, and phosphorus in the urine.  - You may have a kidney stone if you      - have pain while urinating    - see blood in your urine    - feel a sharp pain in your back or lower abdomen    - If you have a small stone that passes on its own easily, you may not have symptoms at all.  - To diagnose kidney stones, your doctor will do a physical exam and ask about your medical history. The doctor may perform urine, blood, and imaging tests to complete the diagnosis.  - The treatment for kidney stones usually depends on their size and what they are made of. You may need pain medicine. You should also drink lots of fluids. If you have a large kidney stone or your urinary tract is blocked, the urologist can remove the stone or break it into small pieces with shock wave lithotripsy, ureteroscopy, or percutaneous nephrolithotomy.  - To prevent kidney stones, you need to know what caused your kidney stone.  - Once you know what type of kidney stone you had, you can make changes in your eating, diet, and nutrition and take medicines to prevent future kidney stones.
What is (are) Porphyria ? 
 Porphyrias are rare disorders that affect mainly the skin or nervous system and may cause abdominal pain. These disorders are usually inherited, meaning they are caused by abnormalities in genes passed from parents to children. When a person has a porphyria, cells fail to change body chemicals called porphyrins and porphyrin precursors into heme, the substance that gives blood its red color. The body makes heme mainly in the bone marrow and liver. Bone marrow is the soft, spongelike tissue inside the bones; it makes stem cells that develop into one of the three types of blood cellsred blood cells, white blood cells, and platelets.
                
The process of making heme is called the heme biosynthetic pathway. One of eight enzymes controls each step of the process. The body has a problem making heme if any one of the enzymes is at a low level, also called a deficiency. Porphyrins and porphyrin precursors of heme then build up in the body and cause illness.
What is (are) Porphyria ? 
 Heme is a red pigment composed of iron linked to a chemical called protoporphyrin. Heme has important functions in the body. The largest amounts of heme are in the form of hemoglobin, found in red blood cells and bone marrow. Hemoglobin carries oxygen from the lungs to all parts of the body. In the liver, heme is a component of proteins that break down hormones, medications, and other chemicals and keep liver cells functioning normally. Heme is an important part of nearly every cell in the body.
What is (are) Porphyria ? 
 Each of the eight types of porphyria corresponds to low levels of a specific enzyme in the heme biosynthetic pathway. Experts often classify porphyrias as acute or cutaneous based on the symptoms a person experiences:
                
- Acute porphyrias affect the nervous system. They occur rapidly and last only a short time.  - Cutaneous porphyrias affect the skin.
                
Two types of acute porphyrias, hereditary coproporphyria and variegate porphyria, can also have cutaneous symptoms.
                
Experts also classify porphyrias as erythropoietic or hepatic:
                
- In erythropoietic porphyrias, the body overproduces porphyrins, mainly in the bone marrow.  - In hepatic porphyrias, the body overproduces porphyrins and porphyrin precursors, mainly in the liver.
                
Table 1 lists each type of porphyria, the deficient enzyme responsible for the disorder, and the main location of porphyrin buildup.
                
Table 1. Types of porphyria
                
Type of Porphyria    Deficient Enzyme    Main Location of Porphyrin Buildup                  delta-aminolevulinate-dehydratase deficiency porphyria    delta-aminolevulinic acid dehydratase    liver        acute intermittent porphyria    porphobilinogen deaminase    liver        hereditary coproporphyria    coproporphyrinogen oxidase    liver        variegate porphyria    protoporphyrinogen oxidase    liver                congenital erythropoietic porphyria    uroporphyrinogen III cosynthase    bone marrow        porphyria cutanea tarda    uroporphyrinogen decarboxylase (~75% deficiency)    liver        hepatoerythropoietic porphyria    uroporphyrinogen decarboxylase (~90% deficiency)    bone marrow        erythropoietic protoporphyria*    ferrochelatase (~75% deficiency)    bone marrow
                
*Protoporphyria XLPP is a variant of erythropoietic protoporphyria.
How many people are affected by Porphyria ? 
 The exact rates of porphyria are unknown and vary around the world. For example, porphyria cutanea tarda is most common in the United States, and variegate porphyria is most common in South America.1
What causes Porphyria ? 
 Most porphyrias are inherited disorders. Scientists have identified genes for all eight enzymes in the heme biosynthetic pathway. Most porphyrias result from inheriting an abnormal gene, also called a gene mutation, from one parent. Some porphyrias, such as congenital erythropoietic porphyria, hepatoerythropoietic porphyria, and erythropoietic protoporphyria, occur when a person inherits two abnormal genes, one from each parent. The likeliness of a person passing the abnormal gene or genes to the next generation depends on the type of porphyria.
                
Porphyria cutanea tarda is usually an acquired disorder, meaning factors other than genes cause the enzyme deficiency. This type of porphyria can be triggered by
                
- too much iron  - use of alcohol or estrogen  - smoking  - chronic hepatitis Ca long-lasting liver disease that causes inflammation, or swelling, of the liver  - HIVthe virus that causes AIDS  - abnormal genes associated with hemochromatosisthe most common form of iron overload disease, which causes the body to absorb too much iron
                
For all types of porphyria, symptoms can be triggered by
                
- use of alcohol  - smoking  - use of certain medications or hormones  - exposure to sunlight  - stress  - dieting and fasting
What are the symptoms of Porphyria ? 
 Some people with porphyria-causing gene mutations have latent porphyria, meaning they have no symptoms of the disorder. Symptoms of cutaneous porphyrias include
                
- oversensitivity to sunlight  - blisters on exposed areas of the skin  - itching and swelling on exposed areas of the skin
                
Symptoms of acute porphyrias include
                
- pain in the abdomenthe area between the chest and hips  - pain in the chest, limbs, or back  - nausea and vomiting  - constipationa condition in which an adult has fewer than three bowel movements a week or a child has fewer than two bowel movements a week, depending on the person  - urinary retentionthe inability to empty the bladder completely  - confusion  - hallucinations  - seizures and muscle weakness
                
Symptoms of acute porphyrias can develop over hours or days and last for days or weeks. These symptoms can come and go over time, while symptoms of cutaneous porphyrias tend to be more continuous. Porphyria symptoms can vary widely in severity.
How to diagnose Porphyria ? 
 A health care provider diagnoses porphyria with blood, urine, and stool tests. These tests take place at a health care providers office or a commercial facility. A blood test involves drawing blood and sending the sample to a lab for analysis. For urine and stool tests, the patient collects a sample of urine or stool in a special container. A health care provider tests the samples in the office or sends them to a lab for analysis. High levels of porphyrins or porphyrin precursors in blood, urine, or stool indicate porphyria. A health care provider may also recommend DNA testing of a blood sample to look for known gene mutations that cause porphyrias.
What to do for Porphyria ? 
 People with an acute porphyria should eat a diet with an average-to-high level of carbohydrates. The recommended dietary allowance for carbohydrates is 130 g per day for adults and children 1 year of age or older; pregnant and breastfeeding women need higher intakes.2 People should avoid limiting intake of carbohydrates and calories, even for short periods of time, as this type of dieting or fasting can trigger symptoms. People with an acute porphyria who want to lose weight should talk with their health care providers about diets they can follow to lose weight gradually.
                
People undergoing therapeutic phlebotomies should drink plenty of milk, water, or juice before and after each procedure.
                
A health care provider may recommend vitamin and mineral supplements for people with a cutaneous porphyria.
What to do for Porphyria ? 
 - Porphyrias are rare disorders that affect mainly the skin or nervous system and may cause abdominal pain.  - Each of the eight types of porphyria corresponds to low levels of a specific enzyme in the heme biosynthetic pathway.  - The exact rates of porphyria are unknown and vary around the world. For example, porphyria cutanea tarda is most common in the United States, and variegate porphyria is most common in South America.  - Most porphyrias result from inheriting an abnormal gene, also called a gene mutation, from one parent.  - Porphyria cutanea tarda is usually an acquired disorder, meaning factors other than genes cause the enzyme deficiency.  - Symptoms of cutaneous porphyrias include      - oversensitivity to sunlight    - blisters on exposed areas of the skin    - itching and swelling on exposed areas of the skin    - Symptoms of acute porphyrias include      - pain in the abdomen    - pain in the chest, limbs, or back    - nausea and vomiting    - constipation    - urinary retention    - confusion    - hallucinations    - seizures and muscle weakness    - A health care provider diagnoses porphyria with blood, urine, and stool tests.  - Treatment for porphyria depends on the type of porphyria the person has and the severity of the symptoms.
What is (are) Diabetes, Heart Disease, and Stroke ? 
 Diabetes is a disorder of metabolismthe way our bodies use digested food for energy. Most of the food we eat is broken down into glucose, the form of sugar in the blood. Glucose is the body's main source of fuel.
                
After digestion, glucose enters the bloodstream. Then glucose goes to cells throughout the body where it is used for energy. However, a hormone called insulin must be present to allow glucose to enter the cells. Insulin is a hormone produced by the pancreas, a large gland behind the stomach.
                
In people who do not have diabetes, the pancreas automatically produces the right amount of insulin to move glucose from blood into the cells. However, diabetes develops when the pancreas does not make enough insulin, or the cells in the muscles, liver, and fat do not use insulin properly, or both. As a result, the amount of glucose in the blood increases while the cells are starved of energy.
                
Over time, high blood glucose levels damage nerves and blood vessels, leading to complications such as heart disease and stroke, the leading causes of death among people with diabetes. Uncontrolled diabetes can eventually lead to other health problems as well, such as vision loss, kidney failure, and amputations.
What is (are) Diabetes, Heart Disease, and Stroke ? 
 Prediabetes is a condition in which blood glucose levels are higher than normal but not high enough for a diagnosis of diabetes. Prediabetes is also called impaired fasting glucose or impaired glucose tolerance. Many people with prediabetes develop type 2 diabetes within 10 years. In addition, they are at risk for heart disease and stroke. With modest weight loss and moderate physical activity, people with prediabetes can delay or prevent type 2 diabetes and lower their risk of heart disease and stroke.
What is (are) Diabetes, Heart Disease, and Stroke ? 
 If you have diabetes, you are at least twice as likely as someone who does not have diabetes to have heart disease or a stroke. People with diabetes also tend to develop heart disease or have strokes at an earlier age than other people. If you are middle-aged and have type 2 diabetes, some studies suggest that your chance of having a heart attack is as high as someone without diabetes who has already had one heart attack. Women who have not gone through menopause usually have less risk of heart disease than men of the same age. But women of all ages with diabetes have an increased risk of heart disease because diabetes cancels out the protective effects of being a woman in her child-bearing years.
                
People with diabetes who have already had one heart attack run an even greater risk of having a second one. In addition, heart attacks in people with diabetes are more serious and more likely to result in death. High blood glucose levels over time can lead to increased deposits of fatty materials on the insides of the blood vessel walls. These deposits may affect blood flow, increasing the chance of clogging and hardening of blood vessels (atherosclerosis).