text
stringlengths 57
1.72k
| relation
stringclasses 125
values | h
dict | t
dict |
|---|---|---|---|
it was suggested that the lcat rate in vitro reflects the in vivo turnover of cholesteryl esters as a part of the turnover of apoprotein-b containing lipoprotein complexes in plasma . | NA | {
"id": "C0008377",
"name": "lcat",
"pos": [
26,
30
]
} | {
"id": "C0008387",
"name": "cholesteryl esters",
"pos": [
78,
96
]
} |
ferritin was detected in all tumour extracts , although the amounts determined were unrelated to histological tumour type . | NA | {
"id": "C0027651",
"name": "tumour",
"pos": [
29,
35
]
} | {
"id": "C0027652",
"name": "histological tumour type",
"pos": [
97,
121
]
} |
the profiles of 4 acute-phase reactant proteins ( aprps ) ( haptoglobin ( hpt ) , alpha1 antitrypsin ( aat ) , alpha1 acid glycoprotein ( agp ) and prealbumin ( palb ) ) have been studied during the evolution of bowel cancer . | NA | {
"id": "C0001347",
"name": "acute-phase",
"pos": [
18,
29
]
} | {
"id": "C0018595",
"name": "haptoglobin",
"pos": [
60,
71
]
} |
the profiles of 4 acute-phase reactant proteins ( aprps ) ( haptoglobin ( hpt ) , alpha1 antitrypsin ( aat ) , alpha1 acid glycoprotein ( agp ) and prealbumin ( palb ) ) have been studied during the evolution of bowel cancer . | NA | {
"id": "C0001347",
"name": "acute-phase",
"pos": [
18,
29
]
} | {
"id": "C0002191",
"name": "alpha1 antitrypsin",
"pos": [
82,
100
]
} |
the profiles of 4 acute-phase reactant proteins ( aprps ) ( haptoglobin ( hpt ) , alpha1 antitrypsin ( aat ) , alpha1 acid glycoprotein ( agp ) and prealbumin ( palb ) ) have been studied during the evolution of bowel cancer . | NA | {
"id": "C0001347",
"name": "acute-phase",
"pos": [
18,
29
]
} | {
"id": "C0029297",
"name": "alpha1 acid glycoprotein",
"pos": [
111,
135
]
} |
in both males and females the ratio of kreyberg group i ( epidermoid and small-cell anaplastic ) to group ii ( adenocarcinoma and carcinoid ) tumours did not increase , despite an 80 % rise in mortality from lung cancer . | NA | {
"id": "C0001418",
"name": "adenocarcinoma",
"pos": [
111,
125
]
} | {
"id": "C0007095",
"name": "carcinoid",
"pos": [
130,
139
]
} |
the highest concentrations per gram of tissue were however in the kidney and liver , representing the two organs of metabolism and excretion of the coumarin . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
116,
126
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
131,
140
]
} |
biochemical studies indicated severe distortion in the plasma profile of free amino acids by week 10 of malnutrition , with a prominent decrease in valine/glycine ratio ( 9 % in the malnourished animals compared to a ratio of 55-63 % in the control group ) . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
78,
89
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
155,
162
]
} |
72 +/- 3 % of all cases of esotropia and/or amblyopia in this sample of children had a refractive error of +2-00 ds or more spherical hypermetropia in the more emmetropic eye , or +1-00 d. or more spherical or cylindrical anisometropia . | NA | {
"id": "C0034951",
"name": "refractive error",
"pos": [
87,
103
]
} | {
"id": "C0020490",
"name": "hypermetropia",
"pos": [
134,
147
]
} |
72 +/- 3 % of all cases of esotropia and/or amblyopia in this sample of children had a refractive error of +2-00 ds or more spherical hypermetropia in the more emmetropic eye , or +1-00 d. or more spherical or cylindrical anisometropia . | NA | {
"id": "C0034951",
"name": "refractive error",
"pos": [
87,
103
]
} | {
"id": "C0003081",
"name": "anisometropia",
"pos": [
222,
235
]
} |
labeling was by 125i iodination of the peptide or its 3- ( 4-hydroxyphenyl ) propionyl derivative , and separation of the immune complex from the free peptide was either by ammonium sulfate precipitation or by centrifugation of the antibodies immobilized on agarose beads . | NA | {
"id": "C0003313",
"name": "immune complex",
"pos": [
122,
136
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
232,
242
]
} |
the nature of the protein environment around the ligand and the interaction between the proximal histidine ( f8 ) and the ligand ( through the iron atom ) impose differences between subunits of hemoglobin and between myoglobins and hemoglobins which are largely , but not entirely , independent of these substituent effects . | NA | {
"id": "C2350441",
"name": "subunits",
"pos": [
182,
190
]
} | {
"id": "C0019046",
"name": "hemoglobins",
"pos": [
232,
243
]
} |
it is proposed that the orientation of this membrane protein , and perhaps others , is determined by interactions of the hydrophobic portion of the protein with the lipid hydrocarbon core . | NA | {
"id": "C0025252",
"name": "membrane",
"pos": [
44,
52
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
148,
155
]
} |
no phosphorylation by either dogfish or rabbit skeletal muscle protein kinase or phosphorylase kinase could be demonstrated , nor any direct interaction with phosphorylase as measured by sh-group reactivity , enzymatic activity , or rate of phosphorylase b to a conversion . | NA | {
"id": "C0033640",
"name": "protein kinase",
"pos": [
63,
77
]
} | {
"id": "C0031713",
"name": "phosphorylase kinase",
"pos": [
81,
101
]
} |
no phosphorylation by either dogfish or rabbit skeletal muscle protein kinase or phosphorylase kinase could be demonstrated , nor any direct interaction with phosphorylase as measured by sh-group reactivity , enzymatic activity , or rate of phosphorylase b to a conversion . | NA | {
"id": "C0017916",
"name": "phosphorylase",
"pos": [
81,
94
]
} | {
"id": "C0031711",
"name": "phosphorylase b",
"pos": [
241,
256
]
} |
dissociation constants for uridine nucleotides dissociating from epimerase-dpnh-nucleotide complexes , measured by ultraviolet absorption and fluorescence techniques , are 12 mum for ump , 14 mum for udp-hexopyranoses , 4 mum for udp-pentopyranoses , 27 mum for p-bromoacetamidophenyl uridyl pyrophosphate , 0.14 mum for udp-4-ketohexopyranose intermediate , and 0.36 mum for udp-4-ketopentopyranose intermediate at 27 degrees c in 0.1 m sodium bicinate buffer at ph 8.5 . | NA | {
"id": "C0041921",
"name": "uridine",
"pos": [
27,
34
]
} | {
"id": "C0042002",
"name": "ump",
"pos": [
183,
186
]
} |
dissociation constants for uridine nucleotides dissociating from epimerase-dpnh-nucleotide complexes , measured by ultraviolet absorption and fluorescence techniques , are 12 mum for ump , 14 mum for udp-hexopyranoses , 4 mum for udp-pentopyranoses , 27 mum for p-bromoacetamidophenyl uridyl pyrophosphate , 0.14 mum for udp-4-ketohexopyranose intermediate , and 0.36 mum for udp-4-ketopentopyranose intermediate at 27 degrees c in 0.1 m sodium bicinate buffer at ph 8.5 . | NA | {
"id": "C0041921",
"name": "uridine",
"pos": [
27,
34
]
} | {
"id": "C0041986",
"name": "uridyl pyrophosphate",
"pos": [
285,
305
]
} |
these results indicate that the dna in native chromatin is in a very rigid form , with its phosphate anions neutralized by structural components , not by free salt . | NA | {
"id": "C0031603",
"name": "phosphate",
"pos": [
91,
100
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
101,
107
]
} |
studies on the enzymatic mechanism of microsomal heme oxygenase were made utilizing various porphyrins and metalloporphyrins of different ring substituents and central metal ions . | NA | {
"id": "C0032712",
"name": "porphyrins",
"pos": [
92,
102
]
} | {
"id": "C0025541",
"name": "metalloporphyrins",
"pos": [
107,
124
]
} |
the binding of imp is facilitated by ornithine and ammonia , but is inhibited by mgatp or atp , indicating that adenine nucleotides can also bind to the imp binding site . | NA | {
"id": "C0001480",
"name": "atp",
"pos": [
83,
86
]
} | {
"id": "C0001413",
"name": "adenine nucleotides",
"pos": [
112,
131
]
} |
moreover , hydrogen-tritium exchange reveals the stabilizing effects of magnesium on the structural properties of phosphatase . | NA | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
11,
19
]
} | {
"id": "C0041119",
"name": "tritium",
"pos": [
20,
27
]
} |
nitrotyrosine chelation of nuclear magnetic resonance shift probes in proteins : application to bovine pancreatic trypsin inhibitor . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
70,
78
]
} | {
"id": "C0003641",
"name": "bovine pancreatic trypsin inhibitor",
"pos": [
96,
131
]
} |
the carboxyl group of asp-194 , which is salt bridged to the amino terminal of ile-16 in native trypsin or other serine proteases , is apparently hydrogen bonded to internal solvent molecules in a loosely organized part of the zymogen structure . | NA | {
"id": "C0041236",
"name": "trypsin",
"pos": [
96,
103
]
} | {
"id": "C0036734",
"name": "serine proteases",
"pos": [
113,
129
]
} |
in keeping with the amino acid compositional similarity suggesting relationships , alanine was found to ba the amino-terminal amino acid of both glycoproteins , and cross-reactivity was demonstrated by immunologic tests . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
20,
30
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
83,
90
]
} |
on the basis of the positions of bands in the enzyme complex , it was determined that the sulfonamide was bound to the enzyme as so2nh2 , rather than as so2nh- . | NA | {
"id": "C0026741",
"name": "enzyme complex",
"pos": [
46,
60
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
119,
125
]
} |
since rr spectroscopy establishes that the final ionization state of the sulfonamide in the enzyme complex is so2nh2 , protonated sulfonamide must bind directly to basic form of the enzyme . | NA | {
"id": "C0026741",
"name": "enzyme complex",
"pos": [
92,
106
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
182,
188
]
} |
the aminoacyl-trna synthetases from all three sources specific argining , isoleucine , leucine , phenylalanine , and valine , as well as the e. coli and yeast enzymes specific for methionine and the e. coli glutamyl-trna synthetase , used as substrates exclusively those trnas terminating in 3'-deoxyadenosine . | NA | {
"id": "C0002529",
"name": "aminoacyl-trna synthetases",
"pos": [
4,
30
]
} | {
"id": "C0017811",
"name": "glutamyl-trna synthetase",
"pos": [
207,
231
]
} |
certain aminoacyl-trna synthetases , including the e. coli , yeast , and calf liver asparagine and tyrosine activating enzymes , the e. coli and yeast cysteinyl-trna synthetases , and the aspartyl-trna synthetase from yeast , utilized both isomeric trnas as substrates , although generally not at the same rate . | NA | {
"id": "C0002529",
"name": "aminoacyl-trna synthetases",
"pos": [
8,
34
]
} | {
"id": "C0004022",
"name": "aspartyl-trna synthetase",
"pos": [
188,
212
]
} |
the cellular content and transcription program of the chloroplast ribosomal rna genes of euglena gracilis z have been determined during the light-induced development of chloroplasts by hybridization of total cell dna or rna to purified 3h-labeled chloroplast ribosomal dna ( [ 3h ] ctrdna ) . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
213,
216
]
} | {
"id": "C0012933",
"name": "ribosomal dna",
"pos": [
259,
272
]
} |
the [ 3h ] ct rdna was purified and characterized by the kinetics of its renaturation with chloroplast dna and rrna , and by the thermal stability of [ 3h ] dna-dna and [ 3h ] dna-rna hybrids . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
111,
115
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
180,
183
]
} |
chloroplast rrna increases from 2 to 26 % of the cellular rna during development , while the percentage of cellular dna represented by ct rdna increases two- to threefold . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
12,
16
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
58,
61
]
} |
correcting for the change in cellular rna and dna content during development , the number of copies of the rrna gene increases less than twofold , while the number of copies of rrna per cell increases sixfold . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
38,
41
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
177,
181
]
} |
the evolution of the cd spectra in both spectral regions of the peptides in aqueous solution during a titration from ph 1 to ph 12 makes it possible to elucidate further the role of ionizable groups and their interaction with aromatic amino acids such as tyrosine . | NA | {
"id": "C0301713",
"name": "aromatic amino acids",
"pos": [
226,
246
]
} | {
"id": "C0041485",
"name": "tyrosine",
"pos": [
255,
263
]
} |
the involvement of membrane ( na+ + k+ ) -atpase ( mg2+-dependent , ( na+ + k+ ) -activated atp phosphohydrolase , e.c . 3.6.1.3 ) in the oxygen consumption of rat brain cortical slices was studied in order to determine whether ( na+ + k+ ) -atpase activity in intact cells can be estimated from oxygen consumption . | NA | {
"id": "C0001479",
"name": "na",
"pos": [
30,
32
]
} | {
"id": "C0001473",
"name": "atp phosphohydrolase",
"pos": [
92,
112
]
} |
[ 3h ] cytochalasin b which behaved identically to the unlabelled compound with respect to binding to these membranes was prepared by reduction of cytochalasin a with nab3h4 . | NA | {
"id": "C0010737",
"name": "cytochalasin b",
"pos": [
7,
21
]
} | {
"id": "C0010739",
"name": "cytochalasin",
"pos": [
147,
159
]
} |
the effects of hypothyroidism and fasting on electrogenic amino acid transfer : possible evidence for multiple neutral amino acid carrier systems in rat jejunum . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
58,
68
]
} | {
"id": "C0301715",
"name": "neutral amino acid",
"pos": [
111,
129
]
} |
creatine phosphokinase extracted from a plasma membrane fraction with potassium chloride and 0.01 % deoxycholate solution is electrophoretically identical to mm isoenzyme of creatine phosphokinase . | NA | {
"id": "C0010287",
"name": "creatine",
"pos": [
0,
8
]
} | {
"id": "C0010291",
"name": "mm isoenzyme",
"pos": [
158,
170
]
} |
the rate of creatine release is also dependent on creatine phosphate concentration in conformance with the kinetic parameters of mm isozyme of creatine phosphokinase . | NA | {
"id": "C0010286",
"name": "creatine",
"pos": [
12,
20
]
} | {
"id": "C0031634",
"name": "creatine phosphate",
"pos": [
50,
68
]
} |
the residual rna synthesis after the addition of rifampicin and [ 3h ] uridine to exponentially growing cells has shown that 56 % of the radioactivity incorporated into total rna belongs to the unstable fraction and 44 % to the fraction containing mature rrna and trna . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
13,
16
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
255,
259
]
} |
complex formation of circular , single-stranded phage fd dna with escherichia coli dna binding protein hd or phage fd gene 5 protein keeps infection of e. coli spheroplasts at the level of free phage dna , whereas complexes of this dna with e. coli dna unwinding protein show a strongly reduced efficiency of transfection . | NA | {
"id": "C0012935",
"name": "single-stranded",
"pos": [
32,
47
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
249,
252
]
} |
the compounds p1- ( adenosine-5 ' ) -p3- ( glucose-6 ) triphosphate ( ap3 glucose ) and p1- ( adenosine-5 ' ) -p4- ( glucose-6 ) tetraphosphate ( ap4 glucose ) were synthesized as possible transition-state analogs for hexokinase ( atp : d-hexose 6- phosphotransferase , ec 2.7.1.1 ) . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
43,
50
]
} | {
"id": "C0019494",
"name": "hexose",
"pos": [
239,
245
]
} |
two of them , which phosphorylated fructose 1.5 times faster than glucose , were designated as hexokinase i and ii ( atp : d-hexose 6-phosphotransferase , ec 2.7.1.1 . ) , and the other with very low or no fructose-phosphorylating activity , as glucokinase ( atp : d-glucose 6-phosphotransferase , ec 2.7.1.2 ) . | NA | {
"id": "C0019494",
"name": "hexose",
"pos": [
125,
131
]
} | {
"id": "C0016745",
"name": "fructose",
"pos": [
206,
214
]
} |
addition of cycloheximide to the culture medium prevented the increase in the hexose-phosphorylating activity and in the fru/glu ratio ( the ratio of enzymatic phosphorylation of fructose to that of glucose ) in the cells . | NA | {
"id": "C0019494",
"name": "hexose",
"pos": [
78,
84
]
} | {
"id": "C0016745",
"name": "fructose",
"pos": [
179,
187
]
} |
the enzyme catalyzed the hydrolysis of a wide variety of phosphomonoesters , but not that of bis ( p-nitrophenyl ) phosphate , adenosine 3',5'-cyclic monophosphate , fructose 1,6-diphosphate , adenosine 5'-diphosphate or adenosine 5'-triphosphate . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
127,
136
]
} | {
"id": "C0001480",
"name": "adenosine 5",
"pos": [
221,
232
]
} |
the calcium activation of the atpase ( atp phosphohydrolase , ec 3.6.1.3 ) activity of cardiac actomyosin reconstituted from bovine cardiac myosin and a complex of actin-tropomyosin-troponin extracted from bovine cardiac muscle at 37 degrees c was studied and compared with similar proteins from rabbit fast skeletal muscle . | NA | {
"id": "C0001476",
"name": "calcium",
"pos": [
4,
11
]
} | {
"id": "C0001473",
"name": "atp phosphohydrolase",
"pos": [
39,
59
]
} |
antibodies specific for the b and m subunits of creatine kinase ( atp : creatine n-phosphotransferase , ec 2.7.3.2 ) isoenzymes were obtained by immunization of rabbits with canine bb and mm creatine kinase . | NA | {
"id": "C0010287",
"name": "creatine",
"pos": [
48,
56
]
} | {
"id": "C0010291",
"name": "mm creatine kinase",
"pos": [
188,
206
]
} |
mitochondrial and nuclei were purified from cultured hamster fibroblasts ( bhk21 cells ) by centrifugation in sucrose gradients . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
61,
72
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
81,
86
]
} |
pretreatment with chloroquine for 3 h , resulted in a 2-2.5 fold increase in 125i-labeled very low density lipoprotein recovered in the liver 45 min after injection of the homologous and heterologous lipoproteins . | NA | {
"id": "C0023825",
"name": "very low density",
"pos": [
90,
106
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
200,
212
]
} |
circulation of large chylomicrons in functionally eviscerated rats markedly increased the rate of hepatic cholesterol uptake when these metabolized lipoproteins were reinjected into recipient animals . | NA | {
"id": "C0008731",
"name": "chylomicrons",
"pos": [
21,
33
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
148,
160
]
} |
uptake of cholesterol from intestinal lipoproteins was essentially a linear function of the amount of chylomicrons administered to the animals and was independent of the level of circulating serum cholesterol and the rate of hepatic cholesterogenesis . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
38,
50
]
} | {
"id": "C0008731",
"name": "chylomicrons",
"pos": [
102,
114
]
} |
substrate saturation kinetics were performed using the 18-fold purified enzyme and the lowest km values were obtained for 3alpha,7alpha-dihydroxy bile acid and bile salt substrates including chenodeoxycholic acid ( km 0.048 mm ) , glycochenodeoxycholic acid ( km 0.083 mm ) and taurochenodeoxycholic acid ( km 0.059 mm ) . | NA | {
"id": "C0008024",
"name": "chenodeoxycholic acid",
"pos": [
191,
212
]
} | {
"id": "C0017903",
"name": "glycochenodeoxycholic acid",
"pos": [
231,
257
]
} |
substrate saturation kinetics were performed using the 18-fold purified enzyme and the lowest km values were obtained for 3alpha,7alpha-dihydroxy bile acid and bile salt substrates including chenodeoxycholic acid ( km 0.048 mm ) , glycochenodeoxycholic acid ( km 0.083 mm ) and taurochenodeoxycholic acid ( km 0.059 mm ) . | NA | {
"id": "C0008024",
"name": "chenodeoxycholic acid",
"pos": [
191,
212
]
} | {
"id": "C0039356",
"name": "taurochenodeoxycholic acid",
"pos": [
278,
304
]
} |
purified preparations of phosphatidylcholine ( lecithin ) : cholesterol acyltransferase ( ec 2.3.1.43 ) , were injected into goats to produce antisera reacting with this enzyme . | NA | {
"id": "C1959616",
"name": "phosphatidylcholine",
"pos": [
25,
44
]
} | {
"id": "C0031617",
"name": "lecithin",
"pos": [
47,
55
]
} |
removal of glucose from the medium also reduced the rate of epinephrine-stimulated lipolysis and the intracellular cyclic amp and atp levels but failed to modify the lipolytic activity of dibutyryl cyclic amp . | NA | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
115,
125
]
} | {
"id": "C0012054",
"name": "dibutyryl cyclic amp",
"pos": [
188,
208
]
} |
the oxidative phosphorylation inhibitors , antimycin a and , under fixed conditions , 2,4-dinitrophenol also strongly decreased the adipocyte cyclic amp and atp levels but inhibited as well the rate of epinephrine- and of dibutyryl cyclic amp-induced lipolysis . | NA | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
142,
152
]
} | {
"id": "C0012054",
"name": "dibutyryl cyclic",
"pos": [
222,
238
]
} |
n-ethylmaleimide , a mixed glycolysis and oxidative phosphorylation inhibitor , not only reduced the intracellular cyclic amp and atp levels and epinephrine- or theophylline-induced lipolysis , but also that stimulated by dibutyryl cyclic amp . | NA | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
115,
125
]
} | {
"id": "C0012054",
"name": "dibutyryl cyclic amp",
"pos": [
222,
242
]
} |
rapid zymogen activation and isolation of serine proteases from an individual mouse pancreas by affinity chromatography : genetical heterogeneity of chymotrypsins of mus musculus . | NA | {
"id": "C0036734",
"name": "serine proteases",
"pos": [
42,
58
]
} | {
"id": "C0008742",
"name": "chymotrypsins",
"pos": [
149,
162
]
} |
our results , however , are consistent with the view that there is no difference between adult and fetal albumin and that the observed altered binding properties of fetal plasma are due to the tight binding of a ligand to fetal albumin in blood , which modifies the protein 's affinity for lipophilic compounds . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
105,
112
]
} | {
"id": "C0033684",
"name": "protein 's",
"pos": [
266,
276
]
} |
the specificity of the assay was established by competitive displacement of 125i-labeled arginine-rich protein from its antiserum by arginine-rich protein and lipoproteins containing this protein , but not by rat albumin or other purified apolipoproteins . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
103,
110
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
213,
220
]
} |
from the effect of ph , activator and inhibitor on the degradation , the proteolytic enzyme to degrade the injected 131i-labeled hen lysozyme was indicated to be mainly cathepsin bl , with the optimal ph of about 5.0 , and the injected 131i-labeled rate lysozyme was mainly degraded by cathepsin d , with the optimal ph of about 3.5 the in vitro degradation of exogenous and endogenous lysozymes showed a tendency similar to the in vivo clearance from the liver and kidney . | NA | {
"id": "C0030940",
"name": "proteolytic enzyme",
"pos": [
73,
91
]
} | {
"id": "C0007428",
"name": "cathepsin",
"pos": [
286,
295
]
} |
similar electron paramagnetic spectral differences between oxy- and deoxy-modified hemoglobins were observed for both these hemoglobins and for the isolated chains , indicating that ligand-induced conformational changes occur in isolated hemoglobin subunits as well as intact hemoglobin tetramers . | NA | {
"id": "C2350441",
"name": "hemoglobin subunits",
"pos": [
238,
257
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
276,
286
]
} |
however , the magnitude of this difference was not only more reduced in the case of the hemoglobins than in that of the subunits but the spectra of both the oxy and deoxy derivatives of the hemoglobins were characteristic of the oxy derivative of a cooperative tetrameric hemoglobin . | NA | {
"id": "C0019046",
"name": "hemoglobins",
"pos": [
88,
99
]
} | {
"id": "C0019016",
"name": "a",
"pos": [
265,
266
]
} |
this appreciable alpha-helical content of delta-crystallin contrasts with the absence of alpha-helix in other lens crystallins . | NA | {
"id": "C0002257",
"name": "alpha",
"pos": [
17,
22
]
} | {
"id": "C0010422",
"name": "crystallins",
"pos": [
115,
126
]
} |
factor x can be converted to the enzymatically active factor xa by russell 's viper venom and in the presence of ca2+ . | NA | {
"id": "C0015518",
"name": "factor x",
"pos": [
0,
8
]
} | {
"id": "C0015520",
"name": "factor xa",
"pos": [
54,
63
]
} |
therefore , the heavy and light chains of both native factor x and factor xa are linked together by disulfides . | NA | {
"id": "C0015518",
"name": "factor x",
"pos": [
54,
62
]
} | {
"id": "C0015520",
"name": "factor xa",
"pos": [
67,
76
]
} |
the uptake and phosphorylation of 2-deoxy-d-glucose by isolated adipocytes of the rat was determined by a method of rapid flotation through oil coupled with separation of sugar from sugar phosphate by chromatography on dowex-1-formate . | NA | {
"id": "C0007004",
"name": "sugar",
"pos": [
171,
176
]
} | {
"id": "C0038655",
"name": "sugar phosphate",
"pos": [
182,
197
]
} |
the fragment has been identified as a 30 amino acid peptide consisting of two linear oligopeptides linked by a disulphide bridge and corresponding to residues 10-25 and 75-88 of the amino acid sequence of nerve growth factor . | NA | {
"id": "C0030956",
"name": "peptide",
"pos": [
52,
59
]
} | {
"id": "C0028954",
"name": "oligopeptides",
"pos": [
85,
98
]
} |
in contrast to glucagon , the cyclic amp-independent hormones did not activate either protein kinase ( ec 2.7.1.37 ) or phosphorylase b kinase ( ec 2.7.1.38 ) . | NA | {
"id": "C0033640",
"name": "protein kinase",
"pos": [
86,
100
]
} | {
"id": "C0031713",
"name": "phosphorylase b kinase",
"pos": [
120,
142
]
} |
lipolysis by isolated white adipocytes from hamsters , as measured by glycerol production , was stimulated by corticotropin , isopropylnorepinephrine ( ine ) , norepinephrine , or epinephrine ( epi ) , in a dose-dependent fashion . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
135,
149
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
180,
191
]
} |
lipolysis was stimulated by five inhibitors of cyclic 3',5'-adenosine monophosphate phosphodiesterase : caffeine , theophylline , 1-methyl-3-isobutyl xanthine , 1-ethyl-4- ( isopropylidenehydrazine ) -1h-pyrazolo- ( 3,4 , -b ) -pyridine-5-carboxylic acid ethyl ester ( sq 20009 ) , and 4- ( 3,4-dimethoxybenzyl ) -2-imidazolidinone ( ro 7-2956 ) . | NA | {
"id": "C0039771",
"name": "theophylline",
"pos": [
115,
127
]
} | {
"id": "C0000096",
"name": "1-methyl-3-isobutyl xanthine",
"pos": [
130,
158
]
} |
the effects of two different concentrations of six antilipolytic agents , prostaglandin e1 , nicotinic acid , phenylisopropyladenosine , 5-methylpyrazole-3-carboxylic acid , adenosine and insulin , were measured . | NA | {
"id": "C0031484",
"name": "phenylisopropyladenosine",
"pos": [
110,
134
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
174,
183
]
} |
erythrocyte membrane na+-k+ atpase and ca++atpase levels were investigated in 11 women treated with ect for endogenous depression and 11 age-matched normal control subjects . | NA | {
"id": "C0001479",
"name": "na",
"pos": [
21,
23
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
43,
49
]
} |
the effects of bacterial neuraminidase on production of hydrogen peroxide ( h2o2 ) and killing of staphylococcus aureus by human polymorphonuclear leukocytes ( pmn ) were studied . | NA | {
"id": "C0031180",
"name": "peroxide",
"pos": [
65,
73
]
} | {
"id": "C0020281",
"name": "h2o2",
"pos": [
76,
80
]
} |
circulating anticoagulants against antihemophilic factor ( ahf , factor viii ) sometimes seem to inactivate other clotting factors as well . | NA | {
"id": "C0015506",
"name": "antihemophilic factor",
"pos": [
35,
56
]
} | {
"id": "C0005789",
"name": "clotting factors",
"pos": [
114,
130
]
} |
measurements of the concentration of clotting factors in highly diluted plasma , or after neutralization of the anticoagulant with purified ahf , have demonstrated the specific nature of the anticoagulant in a patient under treatment with diphenylhydantoin . | NA | {
"id": "C0005789",
"name": "clotting factors",
"pos": [
37,
53
]
} | {
"id": "C0015506",
"name": "ahf",
"pos": [
140,
143
]
} |
furthermore , as a first step in establishing that guanine nucleotides are regulators of vascular adenylate cyclase , both gtp and gpp ( nh ) p were found to be potent activators of adenylate cyclase from blood vessels . | NA | {
"id": "C0018328",
"name": "guanine nucleotides",
"pos": [
51,
70
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
123,
126
]
} |
furthermore , as a first step in establishing that guanine nucleotides are regulators of vascular adenylate cyclase , both gtp and gpp ( nh ) p were found to be potent activators of adenylate cyclase from blood vessels . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
123,
126
]
} | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
131,
143
]
} |
5 the adenine nucleotides adenosine 5'-diphosphate ( adp ) and adenosine 5'-triphosphate ( atp ) hyperpolarize guinea-pig liver cells in the dose range 0.1-1.0 mm . | NA | {
"id": "C0001413",
"name": "adenine nucleotides",
"pos": [
6,
25
]
} | {
"id": "C0001459",
"name": "adenosine 5",
"pos": [
63,
74
]
} |
5 the adenine nucleotides adenosine 5'-diphosphate ( adp ) and adenosine 5'-triphosphate ( atp ) hyperpolarize guinea-pig liver cells in the dose range 0.1-1.0 mm . | NA | {
"id": "C0001413",
"name": "adenine nucleotides",
"pos": [
6,
25
]
} | {
"id": "C0001480",
"name": "adenosine 5",
"pos": [
63,
74
]
} |
1 isolated pulmonary arterial and vein strips from sensitized or non-sensitized chickens exhibited dose-dependent contractions to adrenaline greater than , noradrenaline greater than , 5-hydroxytryptamine greater than , histamine greater than , dopamine . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
130,
140
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
156,
169
]
} |
2 these preparations have the characteristics of plasma membranes and both heart and lung respond to beta-adrenoceptor agonists in the order : ( +/- ) -isoprenaline greater than ( - ) -noradrenaline greater than ( - ) -adrenaline greater than ( + ) -isoprenaline greater than salbutamol . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
185,
198
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
219,
229
]
} |
effects of thyroidectomy and l-thyroxine on adrenaline and noradrenaline concentrations in the adrenal glands and plasma of rats during the pro-oestrous phase of the oestrous cycle and pregnancy . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
44,
54
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
59,
72
]
} |
2 adrenal adrenaline and noradrenaline declined significantly after thyroidectomy in pro-oestrous and pregnant females but the effects were more marked in pregnant females . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
10,
20
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
25,
38
]
} |
the effects of intraportal injections of noradrenaline , adrenaline , vasopressin and angiotensin on the hepatic portal vascular bed of the dog : marked tachyphylaxis to angiotensin . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
41,
54
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
57,
67
]
} |
3 noradrenaline and adrenaline were injected intraportally in graded doses which caused dose-dependent increases in the hepatic portal vascular resistance . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
2,
15
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
20,
30
]
} |
the potencies of the aliphatic amino acids , gamma-aminobutyric acid ( gaba ) , beta-alanine and glycine were compared with the potencies of conformationally restricted cyclopentane and cyclohexane amino acid analogues . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
97,
104
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
198,
208
]
} |
1 histamine and 2-methyl-histamine ( h1-receptor agonist ) caused dose-dependent increases in capillary permeability in albino mice , but 4-methyl-histamine ( h2-receptor agonist ) caused no significant increase . | NA | {
"id": "C0019588",
"name": "histamine",
"pos": [
2,
11
]
} | {
"id": "C0025779",
"name": "methyl-histamine",
"pos": [
140,
156
]
} |
the 123-iodine isotope possesses distinct advantages over existing isotopes , permitting high resolution imaging whilst delivering a low integrated radiation dose . | NA | {
"id": "C0021969",
"name": "iodine",
"pos": [
8,
14
]
} | {
"id": "C0022262",
"name": "isotopes",
"pos": [
67,
75
]
} |
in further studies on axonally transported protein in the goldfish visual system , the turnover of rapidly transported [ 3h ] proline-labeled protein was examined . | NA | {
"id": "C0007292",
"name": "transported protein",
"pos": [
31,
50
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
142,
149
]
} |
this inhibition is partially overcome only by adenine ( of a number of purines tested ) , with an inhibition index of 0.025 . | NA | {
"id": "C0001407",
"name": "adenine",
"pos": [
46,
53
]
} | {
"id": "C0034140",
"name": "purines",
"pos": [
71,
78
]
} |
( 1 ) if wheat embryo 5s and 5.8s rrna are differentially labelled , it can be shown that there is highly selective association of 5s [ 14c ] rna with 18s rrna , and of 5.8s [ 3h ] rna with 26s rrna when a solution ( 0.3 m nacl ) that contains approximately equimolar amounts of the four ribosomal polynucleotides is heated briefly ( 3 min ) at 60 degrees c . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
34,
38
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
195,
198
]
} |
our preparation of diphtheria exotoxin appeared to have a slightly higher adp-ribosylating efficiency than did pseudomonas toxin . | NA | {
"id": "C0015309",
"name": "exotoxin",
"pos": [
30,
38
]
} | {
"id": "C0040549",
"name": "toxin",
"pos": [
123,
128
]
} |
our results suggest that there are significant differences in the mechanisms of cellular intoxication by pseudomonas and diphtheria exotoxins and that these differences probably exist in the attachment or internalization stages of toxin action . | NA | {
"id": "C0015309",
"name": "exotoxins",
"pos": [
132,
141
]
} | {
"id": "C0040549",
"name": "toxin",
"pos": [
231,
236
]
} |
the extensive vessel involvement with amyloid deposition and the absence of changes indicative of muscular dystropyy or inflammatory myopathy leads us to favor an ischemic basis for this patient 's myopathy . | NA | {
"id": "C0027121",
"name": "inflammatory myopathy",
"pos": [
120,
141
]
} | {
"id": "C0026848",
"name": "myopathy",
"pos": [
198,
206
]
} |
we have reviewed the literature and described experience in treating ewing 's sarcoma and osteosarcoma before and during the era of intensive systemic chemotherapy . | NA | {
"id": "C0553580",
"name": "ewing 's",
"pos": [
69,
77
]
} | {
"id": "C0029463",
"name": "osteosarcoma",
"pos": [
90,
102
]
} |
this latter group of different syndromes and diseases differs significantly in their clinical presentation from each other as well as from hodgkin 's disease . | NA | {
"id": "C0039082",
"name": "syndromes",
"pos": [
31,
40
]
} | {
"id": "C0012634",
"name": "diseases",
"pos": [
45,
53
]
} |
a comparison of the two thiopurine cyclic nucleotides with their nucleoside counterparts has suggested that ( a ) the thio derivatives act by a common mechanism which is different from that exerted by the methylthio derivatives , and ( b ) the methylthio cyclic nucleotide acts , at least in part , by a mechanism which differs from that exerted by the methylthio nucleoside . | NA | {
"id": "C0028631",
"name": "cyclic nucleotides",
"pos": [
35,
53
]
} | {
"id": "C0028630",
"name": "nucleotide",
"pos": [
262,
272
]
} |
the accumulation of cyclic amp in response to isoproterenol or the naturally occurring catecholamine epinephrine was , however , significantly diminished 9 to 24 hr after application of tpa . | NA | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
46,
59
]
} | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
87,
100
]
} |
of the cell lines tested , the supernatant from polyoma virus-induced tumor cells was the strongest inhibitor , although supernatants from simian virus 40-transformed 3t3 , dimethylbenzanthracene-induced tumor cells , and chinease hamster ovary fibroblasts also possessed inhibitory activity . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
3,
6
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
245,
256
]
} |
the spontaneous transformants , as compared with nonneoplastic fibroblasts derived from the same cell , showed similar saturation densities and serum dependence . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
63,
74
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
97,
101
]
} |