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stringlengths 57
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stringclasses 125
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dict |
|---|---|---|---|
the higher affinity of oil red stain for vldl- than for ldl-immunoprecipitation zones is peculiar to this lipoprotein class , and crossed immunoelectrophoretograms may thus be helpful for laboratory diagnosis of types iib and iv in problematic cases . | NA | {
"id": "C0023825",
"name": "vldl",
"pos": [
41,
45
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
106,
117
]
} |
however , the molar enzyme is more susceptible to heat denaturation , presumably due to the presence of a higher level of the heat-labile isoenzyme form a in this tissue . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
20,
26
]
} | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
138,
147
]
} |
serially cultured fibroblasts from gouty overproducers of uric acid displayed increased purine enzyme levels with increasing cell passage while fibroblasts from normal donors showed little change in activity . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
125,
129
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
144,
155
]
} |
to avoid cl restriction in 6 patients with crf ( ccr 10-15 ml/min ) on an estimated 10 meq na and cl diet , electrolyte ex was compared on nacl supplements of 200 meq/day versus a daily mixture of nahco3 ( 100meq ) and nacl ( 100 meq ) . | NA | {
"id": "C0008203",
"name": "cl",
"pos": [
9,
11
]
} | {
"id": "C0037494",
"name": "nacl",
"pos": [
219,
223
]
} |
mean +/- sem ex of na , cl , hco3 meq/day and ccr and deltawt ( lbs ) are compared below for the 4th day of nacl vs nahco3 intake . | NA | {
"id": "C0008203",
"name": "cl",
"pos": [
24,
26
]
} | {
"id": "C0037494",
"name": "nacl",
"pos": [
108,
112
]
} |
mean +/- sem ex of na , cl , hco3 meq/day and ccr and deltawt ( lbs ) are compared below for the 4th day of nacl vs nahco3 intake . | NA | {
"id": "C0005367",
"name": "hco3",
"pos": [
29,
33
]
} | {
"id": "C0074722",
"name": "nahco3",
"pos": [
116,
122
]
} |
greater na ex on nahco3 may depend on severe cl restriction and/or higher serum hco3 levels . | NA | {
"id": "C0074722",
"name": "nahco3",
"pos": [
17,
23
]
} | {
"id": "C0005367",
"name": "hco3",
"pos": [
80,
84
]
} |
plasma elimination curves for methadone , laam , and its metabolites , noracetylmethadol ( n-laam ) and dinoracetylmethadol ( dn-laam ) , were determined after acute and chronic administration . | NA | {
"id": "C0025605",
"name": "methadone",
"pos": [
30,
39
]
} | {
"id": "C0025607",
"name": "laam",
"pos": [
129,
133
]
} |
a double-blind clinical trial was conducted in a non-fluoridated community to determine the effect on enamel fluoride and caries experience of daily rinsing in school with 1,000 parts/10 ( 6 ) solutions of ammonium fluoride or sodium fluoride at ph 4.4 . | NA | {
"id": "C0016327",
"name": "fluoride",
"pos": [
109,
117
]
} | {
"id": "C0037508",
"name": "sodium",
"pos": [
227,
233
]
} |
enamel fluoride levels at the end of 2 years were 3,124 parts/10 ( 6 ) ( ammonium fluoride ) , 2,771 parts/10 ( 6 ) ( sodium fluoride ) , and 2,603 parts/10 ( 6 ) ( placebo ) , p = 0.025 . | NA | {
"id": "C0016327",
"name": "fluoride",
"pos": [
7,
15
]
} | {
"id": "C0037508",
"name": "sodium fluoride",
"pos": [
118,
133
]
} |
tests for opsonic activity , long chain formation , and precipitins were investigated for ability to detect antibodies to the antiphagocytic factor of group e streptococci . | NA | {
"id": "C0032936",
"name": "precipitins",
"pos": [
56,
67
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
108,
118
]
} |
forty strains of bacteroides sp . were tested against three nitroimidazole compounds , metronidazole , tinidazole and nimorazole and the aminoglycosidic antibiotic spectinomycin . | NA | {
"id": "C0028179",
"name": "nitroimidazole",
"pos": [
60,
74
]
} | {
"id": "C0025872",
"name": "metronidazole",
"pos": [
87,
100
]
} |
forty strains of bacteroides sp . were tested against three nitroimidazole compounds , metronidazole , tinidazole and nimorazole and the aminoglycosidic antibiotic spectinomycin . | NA | {
"id": "C0028179",
"name": "nitroimidazole",
"pos": [
60,
74
]
} | {
"id": "C0028095",
"name": "nimorazole",
"pos": [
118,
128
]
} |
nevertheless , this last group of strains , with the exception of one pseudomonas , proved to be sensitive to the association of fosfomycin with a beta-lactamin ( carbenicillin , amoxycillin ) or an aminoglycoside ( gentamicin , tobramycin ) . | NA | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
199,
213
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
216,
226
]
} |
of a total of 45 cases , 34 were exclusively treated with fosfomycin ( 2 g by the intramuscular route and 2 g by the oral route ) and 11 cases were treated with a double association of fosfomycin with a beta-lactamin ( carbenicillin or amoxycillin ) or an aminoglycoside ( gentamicin ) , after having studied the bactericidal activity of the association in vitro . | NA | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
256,
270
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
273,
283
]
} |
the minimum inhibitory concentrations were determined in 98 strains of anaerobic bacteria that came from clinical samples against fosfomycin , penicillin , cephalothin , tetracycline , chloramphenicol , clindamycin and lincomycin . | NA | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
203,
214
]
} | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
219,
229
]
} |
the results obtained indicate that fosfomycin is usually inactive against bacteroides sp . and is active up to 32 mug/ml or less against 85 % of peptococcus and 95 % of peptostreptococcus , being consequently comparatively less active than the rest of the antibiotics that were tested against bacteroides , sp. , while against peptococcus and peptostreptococcus it is less active than penicillin , cephalothin , clindamycin and lincomycin , and somewhat more active than chloramphenicol and tetracycline . | NA | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
412,
423
]
} | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
428,
438
]
} |
it was striking that the su-sensitive n. gonorrheoeae strains showed no potentiation of su by tr when a su/tr ratio of 5:1 is used . | NA | {
"id": "C0038689",
"name": "su",
"pos": [
25,
27
]
} | {
"id": "C0041044",
"name": "su/tr",
"pos": [
104,
109
]
} |
a total of 1109 determinations of digoxin concentration in serum were performed in 317 patients with cardiac failure during oral maintenance therapy with digoxin , beta-acetyldigoxin and beta-methyldigoxin . | NA | {
"id": "C0012265",
"name": "digoxin",
"pos": [
34,
41
]
} | {
"id": "C0025132",
"name": "beta-methyldigoxin",
"pos": [
187,
205
]
} |
the daily doses recommended for oral maintenance therapy are 4mug/kg for beta-methyldigoxin , 5 mug/kg for beta-acetyldigoxin , and 8 mug/kg for digoxin . | NA | {
"id": "C0025132",
"name": "beta-methyldigoxin",
"pos": [
73,
91
]
} | {
"id": "C0012265",
"name": "digoxin",
"pos": [
145,
152
]
} |
it acts by combining with plasma antithrombin , thereby accelerating the neurtalisation of thrombin and other acitvated coagulation factors . | NA | {
"id": "C0040018",
"name": "thrombin",
"pos": [
37,
45
]
} | {
"id": "C0005789",
"name": "coagulation factors",
"pos": [
120,
139
]
} |
catecholamine levels in hypophysial portal plasma were determined in pregnant and non-pregnant female rats as well as in intact and castrated male rats , using a radioenzymatic assay for the simultaneous determination of dopamine , norepinephrine , and epinephrine in 50 mul of plasma . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
232,
246
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
253,
264
]
} |
dopamine levels in arterial plasma from the same rats were low or undetectable ( 0.4 -- 0.8 ng/ml1 . norepinephrine and epinephrine was undetectable ( less than 0.6 ng/ml ) in portal as well as arterial plasma from these rats . the major catecholamine in extracts of the hypothalamus from pregnant rats was norepinephrine , whereas that in the posterior pituitary was dopamine . dopamine levels in portal plasma collected during proestrus , estrus , diestrus 1 , and diestrus 2 , were 1.32 +/- 0.21 ( mean +/- se ) , 3.87 +/- 0.96 , 3.11 +/- 0.73 , and 2.3 +/- 0.45 , respectively . dopamine in portal plasma from intact and from castrated male rats was approximately 0.6 ng/ml . norepinephrine and epinephrine were not detectable in either portal or arterial plasma from these animals . it is concluded 1 ) that dopamine is secreted into hypophysial portal blood in significant quantities during pregnancy , 2 ) that hypothalamic secretion of dopamine in cyclic rats is greatest during the day of estrus and early diestrus and at least on the day of proestrus , and 3 ) that these findings support the view that dopamine of hypothalamic origin may have an important role in the regulation of anterior pituitary function . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
101,
115
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
699,
710
]
} |
moreover , progesterone production by mid-luteal phase cells was consistently stimulated ( p less than 0.01 ) by the presence of 100 ng hcg/ml , whereas late luteal phase cells were less sensitive or unresponsive to exogenous gonadotropin . | NA | {
"id": "C0018062",
"name": "hcg",
"pos": [
136,
139
]
} | {
"id": "C0018061",
"name": "gonadotropin",
"pos": [
226,
238
]
} |
changes in the content of calcitonin in plasma and ultimobranchial glands of chicks during embryonic development were measured using a radioimmunoassay for salmon calcitonin that readily detects chicken calcitonin . | NA | {
"id": "C0073994",
"name": "salmon calcitonin",
"pos": [
156,
173
]
} | {
"id": "C0006668",
"name": "calcitonin",
"pos": [
203,
213
]
} |
rat [ 125i ] sm was displaced by hsmc and rsm and human nsila-s , partially displaced by procine proinsulin and poorly displaced by rat insulin . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
97,
107
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
136,
143
]
} |
1-methyl-3-isobutylxanthine and theophylline blocked the activation by cyclic gmp of cyclic gmp of cyclic amp hydrolysis , whereas ro 20-1724 ( 4- ( 3-butoxy-4-methoxybenzyl ) -2-imidazolidinone ) , a non-methylxanthine inhibitor of phosphodiesterases , did not alter this effect . | NA | {
"id": "C0000096",
"name": "1-methyl-3-isobutylxanthine",
"pos": [
0,
27
]
} | {
"id": "C0039771",
"name": "theophylline",
"pos": [
32,
44
]
} |
this inhibitory effect of carbamoylcholine was blocked by theophylline and 1-methyl-3-isobutylxanthine , but not by ro 20-1724 . | NA | {
"id": "C0039771",
"name": "theophylline",
"pos": [
58,
70
]
} | {
"id": "C0000096",
"name": "1-methyl-3-isobutylxanthine",
"pos": [
75,
102
]
} |
the importance of the tyrosyl residues of lutropin alpha ( as opposed to those of lutropin beta ) is also supported by the similarity of the effect of alkali on the cd spectra of lutropin and lutropin alpha . | NA | {
"id": "C0065261",
"name": "lutropin beta",
"pos": [
82,
95
]
} | {
"id": "C0023607",
"name": "lutropin",
"pos": [
192,
200
]
} |
further evidence for this involvement was also obtained by a comparison of the alkali-induced changes of refolded lutropin ( alpha + beta recombinant ) and the product obtained by recombination of des- ( 92 -- 96 ) -lutropin alpha ( obtained from carboxypeptidase treatment of the alpha-subunit ) and lutropin beta . | NA | {
"id": "C0023607",
"name": "lutropin",
"pos": [
114,
122
]
} | {
"id": "C0065261",
"name": "lutropin beta",
"pos": [
301,
314
]
} |
analysis of the ribosomal proteins with two-dimensional electrophoresis revealed that of the 29 proteins identified in the small subunit , only protein s6 was phosphorylated . | NA | {
"id": "C0035552",
"name": "ribosomal proteins",
"pos": [
16,
34
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
144,
151
]
} |
the codon properties of a nucleic acid base in messenger rna can be predicted on the basis of its specificity in polynucleotide interactions . | NA | {
"id": "C0009221",
"name": "codon",
"pos": [
4,
9
]
} | {
"id": "C0035696",
"name": "messenger rna",
"pos": [
47,
60
]
} |
diazepam was metabolized by human foetal liver microsomes to n-desmethyldiazepam and n-methyloxazepam as early as the 13th week of gestation . | NA | {
"id": "C0012010",
"name": "diazepam",
"pos": [
0,
8
]
} | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
63,
80
]
} |
catecholamines , in the order isoproterenol greater than epinephrine greater than norepinephrine , increase the rate of camp formation . | NA | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
0,
14
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
30,
43
]
} |
catecholamines , in the order isoproterenol greater than epinephrine greater than norepinephrine , increase the rate of camp formation . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
57,
68
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
82,
96
]
} |
epinephrine , norepinephrine and serotonin were found to reduce the histamine uptake and the formation of methylhistamine , in a dose-dependent fashion . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
0,
11
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
14,
28
]
} |
intracerebroventricular administration of methionine-enkephalin or morphine sulfate immediately prior to naloxone administration inhibited the precipitated withdrawal jumping response in mice rendered dependent on morphine by the pellet implantation method . | NA | {
"id": "C0066814",
"name": "morphine",
"pos": [
67,
75
]
} | {
"id": "C0026549",
"name": "morphine",
"pos": [
214,
222
]
} |
the effect of secretotogues and 2-methylpentan-2,4-diol on the microtubule-tubulin equilibrium and the release of growth hormone from bovine anterior pituitary slices . | NA | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
114,
128
]
} | {
"id": "C0032016",
"name": "anterior pituitary",
"pos": [
141,
159
]
} |
in general , amino acid concentrations were higher in follicular fluid than in blood plasma : only the concentration of cys was significantly lower in follicular fluid than in plasma , while asp , thr , glu , glu-nh2 , gly , ala , and met showed concentrations that were not significantly different in either biologic fluid . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
13,
23
]
} | {
"id": "C0017890",
"name": "gly",
"pos": [
219,
222
]
} |
patients with chronic liver disease with superimposed acute insults , i.e. , gastrointestinal bleeding , infection , alcoholic hepatitis , had elevated levels of the aromatic amino acids , phenylalanine , tyrosine , and tryptophan , as well as methionine , glutamate , and aspartate , whereas levels of the branched chain amino acids , valine , leucine , and isoleucine , were consistently depressed . | NA | {
"id": "C0301713",
"name": "aromatic amino acids",
"pos": [
166,
186
]
} | {
"id": "C0031453",
"name": "phenylalanine",
"pos": [
189,
202
]
} |
patients with chronic liver disease with superimposed acute insults , i.e. , gastrointestinal bleeding , infection , alcoholic hepatitis , had elevated levels of the aromatic amino acids , phenylalanine , tyrosine , and tryptophan , as well as methionine , glutamate , and aspartate , whereas levels of the branched chain amino acids , valine , leucine , and isoleucine , were consistently depressed . | NA | {
"id": "C0301713",
"name": "aromatic amino acids",
"pos": [
166,
186
]
} | {
"id": "C0041485",
"name": "tyrosine",
"pos": [
205,
213
]
} |
patients with chronic liver disease with superimposed acute insults , i.e. , gastrointestinal bleeding , infection , alcoholic hepatitis , had elevated levels of the aromatic amino acids , phenylalanine , tyrosine , and tryptophan , as well as methionine , glutamate , and aspartate , whereas levels of the branched chain amino acids , valine , leucine , and isoleucine , were consistently depressed . | NA | {
"id": "C0301713",
"name": "aromatic amino acids",
"pos": [
166,
186
]
} | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
220,
230
]
} |
patients with chronic liver disease with superimposed acute insults , i.e. , gastrointestinal bleeding , infection , alcoholic hepatitis , had elevated levels of the aromatic amino acids , phenylalanine , tyrosine , and tryptophan , as well as methionine , glutamate , and aspartate , whereas levels of the branched chain amino acids , valine , leucine , and isoleucine , were consistently depressed . | NA | {
"id": "C0002521",
"name": "branched",
"pos": [
307,
315
]
} | {
"id": "C0042285",
"name": "valine",
"pos": [
336,
342
]
} |
patients with chronic liver disease with superimposed acute insults , i.e. , gastrointestinal bleeding , infection , alcoholic hepatitis , had elevated levels of the aromatic amino acids , phenylalanine , tyrosine , and tryptophan , as well as methionine , glutamate , and aspartate , whereas levels of the branched chain amino acids , valine , leucine , and isoleucine , were consistently depressed . | NA | {
"id": "C0002521",
"name": "branched",
"pos": [
307,
315
]
} | {
"id": "C0023401",
"name": "leucine",
"pos": [
362,
369
]
} |
patients with chronic liver disease with superimposed acute insults , i.e. , gastrointestinal bleeding , infection , alcoholic hepatitis , had elevated levels of the aromatic amino acids , phenylalanine , tyrosine , and tryptophan , as well as methionine , glutamate , and aspartate , whereas levels of the branched chain amino acids , valine , leucine , and isoleucine , were consistently depressed . | NA | {
"id": "C0002521",
"name": "branched",
"pos": [
307,
315
]
} | {
"id": "C0022192",
"name": "isoleucine",
"pos": [
359,
369
]
} |
those patients with previously normal livers and acute hepatic necrosis , i.e. , `` '' fulminant hepatitis , '' '' had grossly elevated levels of all amino acids except the branched chain amino acids , which were normal . | NA | {
"id": "C0002520",
"name": "l amino aci",
"pos": [
148,
159
]
} | {
"id": "C0002521",
"name": "branched chain amino aci",
"pos": [
173,
199
]
} |
combination pills and sequentials are widely used , the possible methods of a pure progestin contraception are : minipills , three-month-injections , implanted silastic capsules with progestional compounds , progestin impregnated intrauterine devices , vaginal silastic rings impregnated with progestional compounds . | NA | {
"id": "C0994475",
"name": "pills",
"pos": [
12,
17
]
} | {
"id": "C0006935",
"name": "capsules",
"pos": [
169,
177
]
} |
the ribosomal fraction exhibited intense protective antigenicity in mice and chickens , but the lipopolysaccharide ( endotoxin ) and the other bacterial cell fraction obtained in this experiment did not . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
96,
114
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
117,
126
]
} |
upon addition of hydrogen ion , urea , and sodium chloride to urines and broth , ph proved to be the major killing factor , but urea and nacl were also bactericidal . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
50,
58
]
} | {
"id": "C0037494",
"name": "nacl",
"pos": [
137,
141
]
} |
the binding of glycolipid to lymphocytes was only partially specific since unlabeled glycolipid r595 , lipid a , and lps did not completely inhibit the uptake of 14c-labeled glycolipid r595 . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
103,
110
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
117,
120
]
} |
infection with p3 virus was accompanied by minimal bronchitis and bronchiolitis only , whereas p9-infected animals exhibited marked bronchitis , bronchiolitis , and pneumonia . | NA | {
"id": "C0006277",
"name": "bronchitis",
"pos": [
51,
61
]
} | {
"id": "C0006271",
"name": "bronchiolitis",
"pos": [
145,
158
]
} |
the complex membrane antigen was exposed on the outside of the mycoplasmic cell because absorption of antiserum with live organisms removed antibody to this component . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
102,
111
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
140,
148
]
} |
the antiendotoxic activity of lipid a antiserum was studied in rabbits , using lipid a ( lipopolysaccharide ) -induced fever and skin necrosis as test systems . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
30,
37
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
89,
107
]
} |
however , in animals that were pretreated ( day 0 ) with a single dose of lipid a ( lipopolysaccharide ) , a significant protective effect of passively transferred antiserum ( day 1 ) to lipid a ( lipopolysaccharide fever ) ( day 2 ) was observed . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
74,
81
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
197,
215
]
} |
also , the lipid a ( lipopolysaccharide ) -induced local shwartzman reaction could be prevented by lipid a antiserum . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
21,
39
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
99,
106
]
} |
the fever protection mediated by lipid a antiserum seemed to be lipid a ( lipopolysaccharide ) specific with regard to both the preparative and the challenge injections . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
33,
40
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
74,
92
]
} |
both groups of hamster sera also gave virtually identical patterns , suggesting that the two enzyme forms used as antigen share common antigenic determinants . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
114,
121
]
} | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
135,
157
]
} |
the presence of the material was not related to the source of malignancy , presence of carcinoembryonic or hepatitis antigens or of such autoantibodies as rheumatoid factor or anti-dna . | NA | {
"id": "C0004358",
"name": "autoantibodies",
"pos": [
137,
151
]
} | {
"id": "C0035448",
"name": "rheumatoid factor",
"pos": [
155,
172
]
} |
the validity of the inert gas clearance method for measuring choroidal blood flow has recently been demonstrated by studying the diffusion of krypton in ocular tissue . | NA | {
"id": "C0017112",
"name": "inert gas",
"pos": [
20,
29
]
} | {
"id": "C0022792",
"name": "krypton",
"pos": [
142,
149
]
} |
the unmounted sections are examined and photographed in the fluorescence microscope , and then stained for acetylcholinesterse according to holmstedt 's modification of the koelle thiocholine method ( incubation for 4-6 h with acetylthiocholine as substrate and mipafox as inhibitor of non-specific cholinesterases ) . | NA | {
"id": "C0039883",
"name": "thiocholine",
"pos": [
180,
191
]
} | {
"id": "C0001066",
"name": "acetylthiocholine",
"pos": [
227,
244
]
} |
a quantitative method has been developed for the determination of alpha- and beta-carotenes and beta-cryptoxanthin , the provitamin a carotenoids in orange juice . | NA | {
"id": "C0053396",
"name": "beta-carotenes",
"pos": [
77,
91
]
} | {
"id": "C0007271",
"name": "carotenoids",
"pos": [
134,
145
]
} |
the relative absorbance values obey beer 's law in the range of 1-10 mug dht/ml ethanol . | NA | {
"id": "C0004922",
"name": "beer 's",
"pos": [
36,
42
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
80,
87
]
} |
the human histone messenger rna ( mrna ) species associated with various polyadenylated [ poly ( a ( + ) ) ] and nonpolyadenylated [ poly ( a ( - ) ) ] components of 4 to 18 s rna were determined by translation of these rna fractions in vitro using a krebs ii ascites cell-free system followed by resolution of histones synthesized in vitro on polyacrylamide gels containing triton x-100 . | NA | {
"id": "C0035696",
"name": "messenger rna",
"pos": [
18,
31
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
220,
223
]
} |
the results of these studies indicate that poly ( a ( - ) ) 4 to 18 s rna from s phase hela polyribosomes contains : ( a ) large quantities of discrete 7.4 and 8 s rna species which are not functional histone mrna ; | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
70,
73
]
} | {
"id": "C0887909",
"name": "functional",
"pos": [
190,
200
]
} |
( c ) 9.2 to 10.7 s rna which contains mixtures of incompletely resolved histone h2b , h2a , and h3 mrna ( these mrna species do not closely correspond to discrete rna subfractions resolvable by our techniques . ) ; | NA | {
"id": "C0035696",
"name": "mrna",
"pos": [
100,
104
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
164,
167
]
} |
the lysine-fermenting clostridium sb4 is shown to contain a new type of beta-keto acid-degrading enzyme that converts 3-keto-5-aminohexanoate and acetyl-coa reversibly to l-3-aminobutyryl-coa and acetoacetate . | NA | {
"id": "C0022618",
"name": "keto acid",
"pos": [
77,
86
]
} | {
"id": "C0000988",
"name": "acetoacetate",
"pos": [
196,
208
]
} |
the product formed from beta-alanyl-coa and acetoacetate is a neutral beta-keto acid , presumably 3-keto-5-aminopentanoic acid ; | NA | {
"id": "C0000988",
"name": "acetoacetate",
"pos": [
44,
56
]
} | {
"id": "C0022618",
"name": "keto",
"pos": [
100,
104
]
} |
the dissociation constants determined for cortisol , cortisone , cortexolone , progesterone , and 20beta-hydroxyprogesterone were at least 1 order of magnitude greater than the corresponding kinetic constants , and these findings suggest the presence of a kinetically insignificant binding site . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
79,
91
]
} | {
"id": "C0020387",
"name": "hydroxyprogesterone",
"pos": [
105,
124
]
} |
effects of various salts show the following effectiveness of anions in dissociating the proteins , so4 ( 2- ) less than cl- less than br- less than clo4- less than scn- less than or equal to i- less than ccl3coo- , the first two members being association-inducing ions . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
61,
67
]
} | {
"id": "C0021966",
"name": "i",
"pos": [
264,
265
]
} |
effects of various salts show the following effectiveness of anions in dissociating the proteins , so4 ( 2- ) less than cl- less than br- less than clo4- less than scn- less than or equal to i- less than ccl3coo- , the first two members being association-inducing ions . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
61,
67
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
264,
268
]
} |
the discrepancy between the effectiveness of the anions in dissociating the protein and the hofmeister pattern of these ions has been discussed . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
49,
55
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
120,
124
]
} |
formation of ethanolamine phosphoglycerides , as a result of serine phosphoglycerides decarboxylation , has been analyzed by using a simplified compartmental model . | NA | {
"id": "C0162448",
"name": "phosphoglycerides",
"pos": [
26,
43
]
} | {
"id": "C0031623",
"name": "serine phosphoglycerides",
"pos": [
61,
85
]
} |
of the 0.67 nmol/mg of protein turned over per h in the diacylserine phosphoglyceride compartment , 0.14 nmol/mg of protein are converted into the ethanolamine phosphoglycerides . | NA | {
"id": "C0162448",
"name": "phosphoglyceride",
"pos": [
69,
85
]
} | {
"id": "C0031618",
"name": "ethanolamine phosphoglycerides",
"pos": [
147,
177
]
} |
while a minor amount of elastase 2 is eluted in a position consistent with alpha1-antitrypsin-elastase 2 complex , no free elastase or free proelastase is detectable . | NA | {
"id": "C0064833",
"name": "elastase 2",
"pos": [
24,
34
]
} | {
"id": "C0030306",
"name": "elastase",
"pos": [
143,
151
]
} |
addition of exogenous elastase 2 to normal serum prior to gel filtration on g-200 produced an increase only in the peak of radioimmunoassayable elastase bound to alpha1-antitrypsin . | NA | {
"id": "C0064833",
"name": "elastase 2",
"pos": [
22,
32
]
} | {
"id": "C0030306",
"name": "elastase",
"pos": [
144,
152
]
} |
human pancreatic elastase 1 , anionic trypsin , chymotrypsin i , and chymotrypsin ii do not cross-react in this assay system . | NA | {
"id": "C0003075",
"name": "anionic",
"pos": [
30,
37
]
} | {
"id": "C0021966",
"name": "i",
"pos": [
109,
110
]
} |
the total enthalpy for assembly of a mole of unliganded hemoglobin tetramers from unliganded chains is -61.6 +/- 3.5 kcal , or approximately twice the value for oxygenated hemoglobin . | NA | {
"id": "C0019016",
"name": "a",
"pos": [
7,
8
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
172,
182
]
} |
two-dimensional electrophoresis of 32p-labeled basic ribosomal proteins showed two labeled proteins , p1 and p2 , both of which were localized to the 40 s ribosomal subunit . | NA | {
"id": "C0035552",
"name": "ribosomal proteins",
"pos": [
53,
71
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
91,
99
]
} |
analysis of hexosamines showed that the sample contained 96 per cent glucosamine , confirming the identification of hyaluronic acid . | NA | {
"id": "C0019478",
"name": "hexosamines",
"pos": [
12,
23
]
} | {
"id": "C0017718",
"name": "glucosamine",
"pos": [
69,
80
]
} |
alcohol then binds to the unprotonated form of the functional group with a pka of 7.6 in the binary enzyme-nad+ complex and converts the enzyme to the alkaline conformation . | NA | {
"id": "C0026741",
"name": "enzyme",
"pos": [
100,
106
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
137,
143
]
} |
this potentiation of the effect of insulin on glucogen synthase i activity depended on the time of incubation with glucose and on the concentration of the hexose . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
115,
122
]
} | {
"id": "C0019494",
"name": "hexose",
"pos": [
155,
161
]
} |
conditions which permitted the annealing of globin mrna to cdna-cellulose were selected and the sequence specificity for hybridization to cdna-cellulose was determined using 28 s ribosomal rna , polyadenylic acid , and mouse l-cell rna . | NA | {
"id": "C0035701",
"name": "ribosomal rna",
"pos": [
179,
192
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
232,
235
]
} |
the amount of large single-stranded polynucleotide generated by the action of the recbc dnase increases as the atp concentration increases and , at 0.5 mm atp , becomes equivalent to the amount of acid-soluble nucleotide formed . | NA | {
"id": "C0032550",
"name": "polynucleotide",
"pos": [
36,
50
]
} | {
"id": "C0028630",
"name": "nucleotide",
"pos": [
210,
220
]
} |
efflux of l-proline from the membrane vesicles , like uptake , showed stimulatory effects when the na+ gradient and l-proline were on the same side , and inhibitory effects when the na+ gradient and the imino acid were on opposite sides of the membrane . | NA | {
"id": "C0033382",
"name": "l-proline",
"pos": [
10,
19
]
} | {
"id": "C0020931",
"name": "imino acid",
"pos": [
203,
213
]
} |
the na+ gradient-dependent rate of l-proline uptake was strongly inhibited by other imino acids , suggesting that l-imino acids have a common transport system . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
37,
44
]
} | {
"id": "C0020931",
"name": "imino acids",
"pos": [
116,
127
]
} |
the observation that both casein and type ii histone are phosphorylated to the same extent at 1 mm and 10 mm mg2+ suggested that high mg2+ may be altering the conformation of phosphorylase kinase thus rendering more phosphorylation sites accessible to protein kinase . | NA | {
"id": "C0031713",
"name": "phosphorylase kinase",
"pos": [
175,
195
]
} | {
"id": "C0033640",
"name": "protein kinase",
"pos": [
252,
266
]
} |
since the phosphorylation of phosphorylase kinase by either the protein kinase-catalyzed or autocatalytic reaction can result in the incorporation of 7 to 9 mol of phosphate , the finding that only about seven sites become phosphorylated by both mechanisms acting together suggest that activation by these two mechanisms may involve common phosphorylation sites . | NA | {
"id": "C0031713",
"name": "phosphorylase kinase",
"pos": [
29,
49
]
} | {
"id": "C0033640",
"name": "protein kinase",
"pos": [
64,
78
]
} |
adenosine and 2-chloroadenosine stimulate adenylate cyclase in membranes from y-1 and i-10 cells at concentrations slightly greater than are effective for steroidogenesis . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
0,
9
]
} | {
"id": "C0000275",
"name": "2-chloroadenosine",
"pos": [
14,
31
]
} |
peak c migrated like glycoprotein pas-2 and protein band 5 , the actin-like , water-soluble membrane protein . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
26,
33
]
} | {
"id": "C0025252",
"name": "membrane protein",
"pos": [
92,
108
]
} |
electron acceptors which function with this enzyme are fad , fmn , riboflavin , ferredoxin , and methyl viologen , but not nad or nadp . | NA | {
"id": "C0016388",
"name": "fmn",
"pos": [
61,
64
]
} | {
"id": "C0035527",
"name": "riboflavin",
"pos": [
67,
77
]
} |
dead end inhibition studies carried out in the presence of the products guanine and ribose 1-phosphate , respectively , showed that the kinetically significant abortive ternary complexes of enzyme-guanine-inorganic orthophosphate ( eqb ) and enzyme-guanose-ribose 1-phosphate ( eap ) are formed . | NA | {
"id": "C0026741",
"name": "complexes",
"pos": [
177,
186
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
242,
248
]
} |
soluble cell extracts from simian virus 40 transformed mouse 3t3 fibroblast cells ( sv101 ) and nontransformed mouse balb/c-3t3 cells were compared as microtubule assembly systems . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
8,
12
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
65,
75
]
} |
the results indicate that membrane proteins are displaced laterally into adjacent membrane regions before the fusion process and that fusion occurs between protein-depleted lipid bilayers . | NA | {
"id": "C0025252",
"name": "membrane",
"pos": [
26,
34
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
156,
163
]
} |
the finding of protein-depleted blebs in regions of plasma and granule membrane interaction raises the interesting possibility that blebbing may be a process for exposing the granule contents to the extracellular space and for the elimination of excess lipid while conserving membrane proteins . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
15,
22
]
} | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
276,
293
]
} |
a heterogeneous cell population is obtained , comprising approximately 60 % parenchymal cells , approximately 10 % myoepithelial cells , and approximately 30 % connective tissue cells , including fibroblasts , plasma cells , and microphages . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
16,
20
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
196,
207
]
} |
the plant lectin , concanavalin a ( con-a ) , and the ionophore , a-23187 ( specific for divalent cations ) , stimulated glucose transport in rat thymocytes . | NA | {
"id": "C0304052",
"name": "plant lectin",
"pos": [
4,
16
]
} | {
"id": "C0009630",
"name": "concanavalin a",
"pos": [
19,
33
]
} |
the effect on chick embryo fibroblasts was visible by four hours and by six hours almost all cells had swelled and were becoming detached . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
27,
38
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
93,
98
]
} |
levels determined in ottawa drinking water were 17 ppt alpha-bhc , 1.3 ppt lindane , 0.7 ppt aldrin , and less than 0.05 ppt for each of heptachlor , heptachlor epoxide , dieldrin , endrin , chlordane , o , p'-ddt , p , p'-ddd , p , p'-ddt , and p , p'-dde . | NA | {
"id": "C0019219",
"name": "heptachlor",
"pos": [
137,
147
]
} | {
"id": "C0019220",
"name": "heptachlor epoxide",
"pos": [
150,
168
]
} |
the 24 h integrated concentrations of progesterone , 17-hydroxyprogesterone ( 17-ohp ) and cortisol were determined in 5 male subjects ranging in age from 25 to 36 years . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
38,
50
]
} | {
"id": "C0020387",
"name": "17-hydroxyprogesterone",
"pos": [
53,
75
]
} |
in addition , there was a decrease in the specific activity of estriol compared with estrone and estradiol as well as measurable levels of estetrol in both patients . | NA | {
"id": "C0014927",
"name": "estriol",
"pos": [
63,
70
]
} | {
"id": "C0014899",
"name": "estetrol",
"pos": [
139,
147
]
} |