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Methods Apoptosis induction was analysed in a Jurkat Tlymphoma cell model by fluorescence microscopy chromatin condensation and nuclear fragmentation, flow cytometry cellular shrinkage, depolarisation of the mitochondrial membrane potential, caspaseactivation and Western blot analysis caspaseactivation. | W1959324886 | [
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"m": "Explaining the significance of the curre... | Identifying a knowledge gap in the field of study | 687,043.0625 |
Composition of Ukrain was analysed by mass spectrometry and LCMS coupling. | W1959324886 | [
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Results Ukrain turned out to be a potent inducer of apoptosis. | W1959324886 | [
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Mechanistic analyses revealed that Ukrain induced depolarisation of the mitochondrial membrane potential and activation of caspases. | W1959324886 | [
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] | Advising cautious interpretation of the findings | 660,363 |
Lack of caspase8, expression of cFLIPL and resistance to death receptor ligandinduced apoptosis failed to inhibit Ukraininduced apoptosis while lack of FADD caused a delay but not abrogation of Ukraininduced apoptosis pointing to a death receptor independent signalling pathway. | W1959324886 | [
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In contrast, the broad spectrum caspaseinhibitor zVADfmk blocked Ukraininduced cell death. | W1959324886 | [
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Moreover, overexpression of Bcl2 or Bclx L and expression of dominant negative caspase9 partially reduced Ukraininduced apoptosis pointing to Bcl2 controlled mitochondrial signalling events. | W1959324886 | [
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... | Identifying a controversy within the field of study | 717,743.0625 |
However, mass spectrometric analysis of Ukrain failed to detect the suggested trimeric chelidonine thiophosphortriamide or putative dimeric or monomeric chelidonine thiophosphortriamide intermediates from chemical synthesis. | W1959324886 | [
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Instead, the Chelidonium majus L. alkaloids chelidonine, sanguinarine, chelerythrine, protopine and allocryptopine were identified as major components of Ukrain. | W1959324886 | [
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Apart from sanguinarine and chelerythrine, chelidonine turned out to be a potent inducer of apoptosis triggering cell death at concentrations of 0.001 mM, while protopine and allocryptopine were less effective. | W1959324886 | [
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... | Contrasting sources with ‘however’ for emphasis | 765,779.0625 |
Similar to Ukrain, apoptosis signalling of chelidonine involved Bcl2 controlled mitochondrial alterations and caspaseactivation. | W1959324886 | [
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Conclusion The potent proapoptotic effects of Ukrain are not due to the suggested Ukrainmolecule but to the cytotoxic efficacy of Chelidonium majus L. alkaloids including chelidonine. | W1959324886 | [
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Cognitivebehavioural therapy is often used for anger treatment. | W2114172571 | [
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An important element of this therapy is exposure to anger evoking stimuli. | W2114172571 | [
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This has allowed the inclusion of Appendix B listing all packaging requirements for magnet wire while still significantly reducing the overall number of pages in the standard. | W1580533610 | [
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Background Weight loss studies were conducted in children without asthma have demonstrated a reduction in systemic inflammation. | W1980347133 | [
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Methods Eighty obese children with bronchial asthma 42 boys, and 38 girls with mean age 13.86 3.21 years were divided into two equal groups. | W1980347133 | [
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The training group received diet regimen, exercise training in addition to the medical treatment for two months, where the control group received the medical treatment only. | W1980347133 | [
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{
"m": "Establishing the importance of the topic for the discipline: time... | Offering an explanation for the findings | 695,840 |
Results There was a 17.5 , 15.5 , 22.4 , 14.1 and 15.9 reduction in mean values of tumor necrosis factoralpha TNFalpha, interleukin6 IL6, interleukin8 IL8, Leptin and body mass index BMI respectively and 38.7 increase in mean values of adiponectin in the training group. | W1980347133 | [
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{
"m": "Contrasting sources with ‘however’ for emphasis",
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{
"m": "Previous research: Approaches tak... | Describing the process: sequence words | 771,008.9375 |
While, there was a 0.7 , 9.0 , 2.8 , 1.6 and 1.2 increase in mean values of TNFalpha, IL6, IL8, Leptin and BMI respectively and 3.9 decrease in mean values of adiponectin in thecontrol group. | W1980347133 | [
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{
"m":... | Establishing the importance of the topic for the world or society | 776,302 |
The mean values of TNFalpha, IL6, IL8, Leptin and BMI was decreased and adiponectin was increased significantly in the training group, however the results of the control group were not significant. | W1980347133 | [
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{
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}... | Describing the process: sequence words | 764,658 |
Also, there were significant differences between both groups at the end of the study. | W1980347133 | [
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"s": 67... | Establishing the importance of the topic for the discipline | 592,579 |
Conclusion Weight loss improves markers of systemic inflammation in obese Saudi children with bronchial asthma. | W1980347133 | [
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{
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{
"m": "Transition: moving to ... | Previous research: highlighting negative outcomes | 638,541 |
Key words obesity, asthma, weight loss, cytokines. | W1980347133 | [
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{
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] | Offering an explanation for the findings | 797,059.0625 |
It is demonstrated that convex functionals are a class of very univer sal nonlinear functionals. | W2358573556 | [
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{
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Two basic forms of the resonance theorem are set up f or a family of convex functionals on a second category normed space. | W2358573556 | [
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Owing to the generality of convex functionals and the theorem forms, these forms of reso nance theorem have wide application in such fields as convex body theory. | W2358573556 | [
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... | Identifying a knowledge gap in the field of study | 827,060.9375 |
The paper considers the doublesided uniform corrosion of an elastic spherical shell under internal and external pressure. | W2007636701 | [
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It is assumed that corrosion rates are piecewise linear functions of maximum principal stress at the related surface. | W2007636701 | [
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"m"... | Surveys and interviews: Reporting response rates | 805,596.9375 |
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Abstract This paper presents an experimental investigation of the! | W1980294523 | [
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effect of horizontalvertical well configuration on oil recovery of Safanyia crude by alkaline flooding. | W1980294523 | [
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Also, the effects of three types of alkali solutions sodium carbonate Na2CO3 sodium orthasilicate Na4SiO4. | W1980294523 | [
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and sodium hydroxide NaOH on cumulative oil recovery, in both secondary and tertiary processes using linear model, vertical vertical two dimensional model, and horizontalvertical schemes, were investigated. | W1980294523 | [
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It was found that displacing Safanyia crude oil by NaOH solution having 1 concentration results in higher oil recovery in both linear and horizontalvertical schemes. | W1980294523 | [
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"... | Implications and/or recommendations for practice or policy | 764,068 |
The highest oil recovery through horizontalvertical schemes was obtained by, placing the horizontal well perpendicular to the line connecting the two vertical wells with a length that does not reach the boundary of the reservoir Also, it was found that oil displacement efficiency in the tertiary process is higher than ... | W1980294523 | [
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Introduction The use of horizontal wells has been increasing very rapidly throughout the oil industry as advances in drilling techniques continue. | W1980294523 | [
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In many reservoirs, horizontal wells can solve a number of oil production problems. | W1980294523 | [
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However, in spite of a tremendous increase in literature references, little information is available on horizontal well applications in enhanced oil recovery EOR methods1. | W1980294523 | [
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{
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Many published articles show that horizontal wells are still used primarily to solve specific production problems, These include low permeability formations especially fractured formations low permeability gas reservoirs, unusual gas sources, gas or water coning, thin formations, and viscous oil2,3. | W1980294523 | [
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Most horizontal well applications of EOR activities have been in the area of thermal recovery, primarily for steam stimulation and steam drive4,5. | W1980294523 | [
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Although there is relatively little published information on the use of horizontal injection wells, other than thermal recovery the for patterns of both horizontal injection and vertical production well, to increase the rate of flooding in EOR has been mentioned6,9. | W1980294523 | [
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Early laboratory work oncaustic flooding through horizontal wells 10 showed that the use of a horizontal wellas an injector in alkaline flooding increased oil recovery by a minimum of 8 o initial oilinplace IOIP compared to vertical wells. | W1980294523 | [
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This paper studies the effect of horizontal 0vertical well configurations in one uater of a fivespot pattern model on oil recovery by alkaline flooding. | W1980294523 | [
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Instead, Safanyia crude oil from Saudi Aramco has been used to investigate qualitatively the effect of horizontalvertical well configuration in one quarter a fivespot model. | W1980294523 | [
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Experimental Work Fluid Properties The physical properties of the fluids used in this study are shown in Table 1. | W1980294523 | [
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The article is devoted to the characteristics of the security order as one of the acts of the Constitutional Court of Ukraine and the practice of its application. | W3194059035 | [
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The boards are invited to give the right to take an immediate initiative to the senates to resolve the issue of issuing a precautionary order in case of sufficient grounds. | W3194059035 | [
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It has been recommended to grant the subject of the right to a constitutional complaint the right to apply to the Constitutional Court of Ukraine with a corresponding petition to secure a constitutional complaint. | W3194059035 | [
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During the disclosure of this issue, the relevant bills aimed at improving the legal nature of the security order in the practice of the Constitutional Court of Ukraine have been analyzed. | W3194059035 | [
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Abstract A new microcalorimeter for measuring thermal effects has been constructed. | W1977444807 | [
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ACKNOWLEDGMENT We thank the National Science Foundation of China for financial support. | W1977444807 | [
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