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Sustained increases in BP by about 20 mm Hg were evoked by i.v. infusion of phenylephrine 15 μgkgmin. | W1120739291 | [
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From interspikeinterval histograms accumulated for each neuron, the shortest, preferred and longest interspikeintervals were calculated. | W1120739291 | [
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The mean discharge rate was also measured. | W1120739291 | [
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During elevation of BP the shortest interspikeinterval lengthened from control value of 7.2 0.2 ms S.E. to 17.4 8 ms, preferred interval increased from 28.3 5.7 ms to 80.7 12.9 ms, and longest interval lengthened from 6440 396 to 7431 387 ms. The discharge rate decreased from 1.437 0.2 to 0.973 0.2 spikess. | W1120739291 | [
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All changes were statistically signifi cant P 0.05. | W1120739291 | [
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Elevated BP lowered correlation coeffi cient between the shortest interval and discharge rate from r 0.347 P 0.03 to r 0.186. | W1120739291 | [
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Immediate eff ects of elevated BP on pattern of discharge of single renal neurons most probably resulted from the central eff ect of phenylephrine on altered interactions between cells generating activity in vasomotor neurons. | W1120739291 | [
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A reversible affinity inhibitor of rat lens aldose reductase RLAR, that can be transformed into an irreversible inhibitor by low doses of Xrays or by exposure to light, has been synthesized and characterized. | W1974036347 | [
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The inhibitor consists of quercitrin, a reversible receptor binding moiety, that is connected through a hexanediamine spacer to an azido containing moiety which becomes chemically reactive when irradiated. | W1974036347 | [
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This reagent, N2nitro4azidophenylhexamethylenediamineN3Oquercit rin, NAPHEXQ, represents a new class of affinity agents which have potential applications as targetentrapped drugs. | W1974036347 | [
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The KIs for quercitrin and NAPHEXQ, both noncompetitive inhibitors, are 0.6 uM and 0.5 uM, respectively. | W1974036347 | [
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Rates are calculated from the tangent of the angle of descent of the linear absorbance vs time plots, measured simply and rapidly with a protractor. | W1974036347 | [
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Irreversible inhibition of RLAR by NAPHEXQ, as a function of the dose of irradiation with either Xrays or light, is consistent with apparent first order kinetics. | W1974036347 | [
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NAPHEXQ is designed as a drug to prevent or reverse diabetic cataract formation by selective photoaffinity inhibition of RLAR with no significant effect on aldose reductase in other tissues. | W1974036347 | [
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The yeast Sir2 protein and its mammalian derivatives play a central role in epigenetic gene silencing, DNA repair and recombination, cellcycle, microtubule organization, and in the regulation of aging. | W1969635366 | [
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We have isolated and characterized the human Sirt1 genomic sequence, which spans a region of 33,660 bp and which has one single genomic locus. | W1969635366 | [
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Determination of the exonintron splice junctions established that SIRT1 is encoded by 9 exons ranging in size from 80 bp exon 6 to 2,120 bp exon 9. | W1969635366 | [
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Characterization of the 5 flanking genomic region, which precedes the Sirt1 open reading frame, revealed a CCAATbox and a number of NFkappaB and GATA transcription factor binding sites in addition to a small 350 bp CpG island. | W1969635366 | [
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The 4,107 bp human Sirt1 mRNA has an open reading frame of 2,244 bp and encodes a 747 aa protein with a predictive molecular weight of 81.7 kDa and an isoelectric point of 4.55. | W1969635366 | [
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Fluorescence in situ hybridization analysis localized the human Sirt1 gene to chromosome 10q21.3. | W1969635366 | [
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... | Referring to a single investigation in the past: researcher prominent | 824,544.9375 |
BACKGROUND Renal impairment and contrastinduced nephropathy CIN have been shown to have an impact on outcome in STEMI patients. | W146351690 | [
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OBJECTIVES The aim of this study was to assess the prevalence an... | W146351690 | [
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Background Providing qualified, evidencebased healthcare to children requires increased knowledge of how cancer affects the young childs life. | W1964128533 | [
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There is a dearth of research focusing on the young childs experience of everyday life. | W1964128533 | [
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... | Noting the lack of or paucity of previous research | 607,730 |
Objective The purpose of this study was to explore young childrens and their parents perceptions of how cancer affects the childs health and everyday life shortly after diagnosis. | W1964128533 | [
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Methods Thirteen children with newly diagnosed cancer aged 1 to 6 years and their parents, connected to a pediatric oncology unit in Southern Sweden, participated in this study through semistructured interviews. | W1964128533 | [
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... | Referring to the literature to justify a method or approach | 702,840.9375 |
Child and parent data were analyzed as a family unit, using qualitative content analysis. | W1964128533 | [
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Analysis led to the following categories feeling like a stranger, feeling powerless, and feeling isolated. | W1964128533 | [
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Conclusions The child wants to be seen as a competent individual requiring information and participation in care. | W1964128533 | [
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Parents need to be a safe haven for their child and not feel forced to legitimize painful and traumatic procedures by assisting with them. | W1964128533 | [
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Research with and on the young child is necessary and a way of making them visible and promoting their health and wellbeing. | W1964128533 | [
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Implications for Practice Nurses need to reevaluate the newly diagnosed childs care routines so as to shift focus from the illness to the child. | W1964128533 | [
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This requires competent nurses, secure in their caring role. | W1964128533 | [
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Many observers have noted that Medicare expenditures will significantly outstrip projected revenues over the course of the next 25 years. | W1992152857 | [
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This paper examines the economic and demographic assumptions behind forecasts of Medicare hospital insurance and supplementary medical insurance expenditures and revenues and analyzes various strategies for closing the impending gap. | W1992152857 | [
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It is argued that the present forecasts already assume considerable success in controlling hospital costs and physician payments, making substantial further savings unlikely. | W1992152857 | [
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Shifting more of the burden onto the elderly through increased cost sharing or higher premiums also will not solve the programs fiscal problems over the long term. | W1992152857 | [
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The remaining alternativeimposing higher income or payroll taxes on the under65 populationis also unlikely to be a welcome solution. | W1992152857 | [
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The authors argue that, eventually, the nation must choose between some form of a twotier system of benefits or a Canadianstyle national health insurance system. | W1992152857 | [
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OBJECTIVE To develop a reversedphase HPLC method of determining the content of hesperidin in Zhengchaihuyin granules. | W2359797089 | [
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METHODS The HPLC system consisted of the phenomenexODS250mm4.6mm,5μm and acetonitrile0.2 phosphoric acid solution2080 as the mobile phase at a flow rate of 1.0mLmin1. | W2359797089 | [
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The detection wavelength was at 283 nm and the column temperature was 30. | W2359797089 | [
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RESULTS The measurement proved to be linear over the range of 0.02208μg4.416μgr0.99999 for hesperidin. | W2359797089 | [
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The average recovery was 96.85 with RSD of 2.29. | W2359797089 | [
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CONCLUSION The method is simple,accurate,good repeatability and can be used for the quality detection of hesperidin in Zhengchaihuyin granules. | W2359797089 | [
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Autonomous platforms and systems are becoming ever more prevalent. | W1970929778 | [
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They have become smaller, cheaper, have longer duration times, and now more than ever, more capable of processing large amounts of information. | W1970929778 | [
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... | Reporting positive and negative reactions | 793,008 |
Despite these significant technological advances, there is still a level of distrust for the public autonomous systems. | W1970929778 | [
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In marine and underwater vehicles, autonomy is particularly important being that communications to and from those vehicles are limited, either due to the length of the mission, the distance from their human operators, the sheer number of vehicles being used, or the data transfer rate available from a remote operator to... | W1970929778 | [
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The premise for this research is to use the MOOSIvP code architecture, developed at MIT, to promote and advance marine vehicle autonomy collective knowledge through a project called HunterPrey. | W1970929778 | [
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This scenario will be distributed to the public through academic institutions and interested parties, who will submit code for the vehicles to compete against one another. | W1970929778 | [
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"s... | Transition: moving to the next result | 688,720.9375 |
The goal for this project is to create and foster an opensource environment where parties can compete and cooperate toward a common goal, the advancement of marine vehicle autonomy. | W1970929778 | [
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In this paper, the HunterPrey scenario is developed, a nominal solution is created, and the parameters for the scenario are analyzed using regression testing through simulation and statistical analysis. | W1970929778 | [
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Thesis Supervisor John J. Leonard Title Professor of Mechanical and Ocean Engineering Thesis Supervisor Michael R. Benjamin Title Research Scientist, Department of Mechanical Engineering | W1970929778 | [
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The important question of the relation between theory and experiment in different physical problems is discussed. | W2084545237 | [
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A number of examples, both widely and little known, are used to show that some physical theories, considered by many as correct because they corresponded to many experimental facts and to the existing level of science, have been found to be false. | W2084545237 | [
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