One-Prompt to Segment All Medical Images
Authors: Junde Wu, Min Xu

Large foundation models known for their strong zero-shot generalization have excelled in visual and language applications. However applying them to medical image segmentation a domain with diverse imaging types and target labels remains an open challenge. Current approaches such as adapting interactive segmentation models like Segment Anything Model (SAM) require user prompts for each sample during inference. Alternatively transfer learning methods like few/one-shot models demand labeled samples leading to high costs. This paper introduces a new paradigm toward the universal medical image segmentation termed 'One-Prompt Segmentation.' One-Prompt Segmentation combines the strengths of one-shot and interactive methods. In the inference stage with just one prompted sample it can adeptly handle the unseen task in a single forward pass. We train One-Prompt Model on 64 open-source medical datasets accompanied by the collection of over 3000 clinician-labeled prompts. Tested on 14 previously unseen datasets the One-Prompt Model showcases superior zero-shot segmentation capabilities outperforming a wide range of related methods. The code and data is released as https://github.com/KidsWithTokens/one-prompt.