Modality-agnostic Domain Generalizable Medical Image Segmentation by Multi-Frequency in Multi-Scale Attention
Authors: Ju-Hyeon Nam, Nur Suriza Syazwany, Su Jung Kim, Sang-Chul Lee

Generalizability in deep neural networks plays a pivotal role in medical image segmentation. However deep learning-based medical image analyses tend to overlook the importance of frequency variance which is critical element for achieving a model that is both modality-agnostic and domain-generalizable. Additionally various models fail to account for the potential information loss that can arise from multi-task learning under deep supervision a factor that can impair the model's representation ability. To address these challenges we propose a Modality-agnostic Domain Generalizable Network (MADGNet) for medical image segmentation which comprises two key components: a Multi-Frequency in Multi-Scale Attention (MFMSA) block and Ensemble Sub-Decoding Module (E-SDM). The MFMSA block refines the process of spatial feature extraction particularly in capturing boundary features by incorporating multi-frequency and multi-scale features thereby offering informative cues for tissue outline and anatomical structures. Moreover we propose E-SDM to mitigate information loss in multi-task learning with deep supervision especially during substantial upsampling from low resolution. We evaluate the segmentation performance of MADGNet across six modalities and fifteen datasets. Through extensive experiments we demonstrate that MADGNet consistently outperforms state-of-the-art models across various modalities showcasing superior segmentation performance. This affirms MADGNet as a robust solution for medical image segmentation that excels in diverse imaging scenarios. Our MADGNet code is available in GitHub Link.