Please select the most similar patent number from A, B, C and D. Which number is?
A method and system for genetic manipulation of sound-sensitive ion channels. The method comprises: acquiring a sound wave (101); focusing the sound wave on endogenous mechanosensitive ion channels of nerve cells to be stimulated, opening the endogenous mechanosensitive ion channels, and/or focusing the sound wave on exogenous mechanosensitive ion channels of the nerve cells to be stimulated, and opening the exogenous mechanosensitive ion channels, to change a membrane potential of the nerve cells (102). This solution implements noninvasive, accurate, and selectively-specific nerve operation and regulation by means of a sound wave.
A: Provided are an antibody or a fragment thereof, which can be specifically bound to an S3-4 ring of a voltage sensor paddle of a domain III of voltage-gated sodium channel Nav1.9 α sub-unit, and is able to inactivate a voltage sensor valve to keep sodium ions from entering nerve cells normally. Also provided is an epitope polypeptide specifically bound to the antibody or the fragment thereof, a pharmaceutical composition comprising the antibody or the fragment thereof, and a use of the antibody or the fragment thereof in preparing a drug for treating diseases related to pains.
B: A neural cell system following the directed induction of human induced pluripotent stem cells (hiPSC) differentiation, an induction method and an application, the method comprising culturing hiPSC in various stages to induce the neural differentiation thereof, the stages comprising: stage a. co-culturing the hiPSC and bone marrow stromal cells (HS5) in an induction culture medium; stage b. continuously culturing the hiPSC by using an HS5 conditioned culture medium; stage c. continuously culturing the hiPSC by using a basic culture medium for culturing neuron cells. The method induces human hiPSC cells to be directionally differentiated into neural system cells, while inhibiting the production of non-neural system cells, thereby obtaining a mature, broad-spectrum neural cell population. The neural cell population has been verified in vitro as mature neurons which release electrical impulses, and has also has been confirmed in mice in vivo to be an effective treatment for nervous system diseases (such as stroke and brain damage).
C: Provided are a genetically engineered T cell and a pharmaceutical composition using the same. The T cell has an endogenous T cell receptor (TCR) that is inactivated or inactive, comprises encoding of an exogenous receptor bindable to a target antigen, and contains an open reading frame regulated by the exogenous receptor. When the exogenous receptor binds to the target antigen, expression of the open reading frame can be initiated. The T cell has a killing effect on tumor cells and has reduced side effects and enhanced safety.
D: An ultrasonic neuromodulation apparatus, comprising a planar ultrasonic transducer (100), a Fresnel acoustic lens (200), and an acoustic wave collimator (300), the planar ultrasonic transducer (100), the Fresnel acoustic lens (200), and the acoustic wave collimator (300) being arranged in sequence, a transmitting end of the planar ultrasonic transducer (100) being used for transmitting a planar ultrasonic wave signal, the excitation frequency of the planar ultrasonic transducer (100) being adjustable, and the focal length of the Fresnel acoustic lens (200) increasing or decreasing as the frequency of the planar acoustic wave rises or falls. The ultrasonic focus depth can be adjusted by means of adjusting the frequency of the planar acoustic wave transmitted by the planar ultrasonic transducer (100), providing a simple and convenient method for stimulating brain nuclei of different depths for ultrasonic neuromodulation.
Answer: D