Please select the most similar patent number from A, B, C and D. Which number is?
An ultrasonic imaging device and a method for detecting endometrial peristalsis. The method comprises: acquiring ultrasound echo data of the endometrium (1), and determining on said basis the peristaltic displacement or peristaltic speed of a point in the endometrium within a preset period of time (2); calculating peristalsis parameters of the endometrium according to the peristaltic displacement or the peristaltic speed of the point in the endometrium within the preset period of time, the peristalsis parameters being used to describe the moving state of endometrial peristalsis (3); and displaying the peristalsis parameters (4). Thus, peristalsis parameters are calculated automatically without relying on the subjective determination of an ultrasound doctor, which improves the accuracy and efficiency of the detection of peristalsis.
A: An ectopic endometrium recognition polypeptide, and a derivative and the use thereof, which belong to the field of medical cell biology. The ectopic endometrium recognition polypeptide comprises a combination of one or more of the following sequences: SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5 and SEQ ID NO: 6. Such polypeptide molecules can specifically recognise ectopic endometrium lesion tissue, and provides a specific recognition tool for the diagnosis and treatment of a patient with endometriosis. As a result of the conservation and specificity of the sequence, the polypeptide is applicable to various types of basic clinical research and applications with regard to human endometriosis, and is also suitable for serving as a research tool in endometriosis modeling laboratory animals.
B: The present invention provides use of an exosomes from decidua NK cells and subsets thereof in preparation of a medicament and an auxiliary therapeutic agent for diseases related to infertility. It was confirmed through experiments that the exosome may treat endometrium growth disorders by promoting endometrial thickness to increase, improving endometrial cell activity, reducing endometrial cell damage, promoting VEGF expression, maintaining endometrium stromal cell stemness and stimulating proliferation, so that the conception success rate of endometrium damage model mice is increased from 20% to 50-70%; and may treat diseases related to maternal-fetal immune tolerance disorders by playing a role of immunologic tolerance, reducing a spontaneous abortion rate and improving a T helper lymphocyte level. In addition, the exosome of the present invention can effectively increase the developmental rate of zygotes fertilized no matter in vivo or in vitro in a multiple mode, and meanwhile, improve in-vitro fertilization rate, implantation rate of transplanting and birth rate, showing positive assisting effects on infertility treatment.
C: An ultrasonic imaging apparatus (10) and method. A vibration mechanism (102) excites a probe (100) to generate shear waves in a target object to perform elasticity measurement; a transmitting circuit (101) excites the probe (100) to transmit ultrasonic waves to the target object, and receives and processes ultrasonic echoes so as to acquire an ultrasonic image of the target object; and the vibration state of the probe (100) is determined after the generation of the shear waves, whether the pressure before and after the generation of the shear waves for elasticity measurement is consistent is determined, and the actual value of a vibration parameter of the probe (100) is controlled to be kept constant. By means of the ultrasonic imaging apparatus (10) and method, the pressure of the probe (100) between target objects after the probe (100) starts to vibrate is detected so as to determine whether empty vibration or sliding occur on the probe (100) and whether a measurement result is valid, thereby preventing the empty vibration of the probe (100) from influencing the service life of the probe (100), and improving the validity of the elasticity measurement result; and according to a vibration signal, a channel signal of the probe (100) is adjusted so as to ensure the actual vibration stability of the probe (100), thereby further improving the accuracy of elasticity detection.
D: Provided is use of a uterine cavity fluid-derived exosome in the preparation of therapeutic drugs and adjuvant therapeutic agents for treating infertility-related diseases. Experiments have demonstrated the exosome achieved the treatment or alleviation of endometrial aplastic diseases by promoting the increase of endometrial thickness, enhancing the viability of endometrial cells, reducing the damage to endometrial cells, promoting expression of VEGF, maintaining the stemness of endometrial stromal cells, and stimulating proliferation; the treatment or alleviation of a maternal-fetal immune tolerance disorder-related diseases is achieved by performing an immune tolerance effect, treating spontaneous abortion, and increasing the level of T-helper lymphocytes. In addition, the exosome can effectively increase the development rate of either fertilized eggs being fertilized in vivo or fertilized in vitro in a multiple manner, and improve the implantation rate and the farrowing rate of in vitro fertilization transplantation, having an auxiliary effect in the treatment of infertility.
Answer: C