Please select the most similar patent number from A, B, C and D. Which number is?
A medical moisturizing eye patch and a preparation method therefor. The eye patch consists of a protective layer, a gel layer and a backing layer. The gel layer is formed by compounding component A which has good biocompatibility, and component B which has moisturizing ingredients. Component A is a pre-treated wet film of bacterial cellulose; component B comprises the following raw materials in percentage by mass: 0.5%-5% of glycerol, 0.05%-5% of sodium hyaluronate with a molecular weight higher than 500,000, 0.05%-5% of sodium hyaluronate with a molecular weight of 1,000-500,000, 0.05%-0.3％ of paraben, the balance being water. The moisturizing effect of the eye patch is long-lasting.
A: A gel of sodium hyaluronate cross-linked by a polyethylene glycol epoxy derivative for injection and a preparation method thereof are provided. The polyethylene glycol epoxy derivative is preferably a compound having a single molecular weight, and a molecule of the compound includes a plurality of ether bonds, and has high water solubility, such that the compound is easily cross-linked with polysaccharides. In addition, since the number of repeating units of polyethylene glycol is more easily adjusted, the chain length thereof is more easily regulated. Therefore, the function of the sodium hyaluronate gel prepared by polyethylene glycol as a cross-linking agent is more easily regulated. The advantages of the cross-linked gel of sodium hyaluronate include low toxicity, low residue, low pushing force, good plasticity, good enzyme resistance, and long in-vivo time. A moderate inactivation process of the cross-linking agent is further disclosed. In the gel, unreacted epoxy groups can be hydrolyzed under a carbonate buffering system of pH 8-9, in order to effectively reduce the difficulty of removing impurities from the cross-linked gel of sodium hyaluronate, avoiding the use of toxic BDDE as a cross-linking agent in the art.
B: Provided is a hydrating mask. A preparation method for the hydrating mask comprises the following steps: (1) mixing a solute comprising glycerin, hyaluronic acid, polyethylene oxide, urea, allantoin, and sodium pyrrolidone carboxylic acid with a solvent to obtain a spinning solution; (2) electrospinning the spinning solution obtained in step (1) to one side of a mask substrate to form a viscous nanofiber layer on the surface of the mask substrate; and (3) adhering a protective layer to the surface of the viscous nanofiber layer obtained in step (2), to obtain the hydrating mask.
C: The invention relates to cross-linked sodium hyaluronate gel for tissue filler for plastic surgery and a preparation method thereof. The gel is prepared by enabling sodium hyaluronate alkaline solution, epoxy group containing long-chain alkane and epoxy group containing cross-linking agent to react for 2-5 hours at 35-50°C, then washing, gelling and sterilizing, wherein the molar ratio of the sodium hyaluronate alkaline solution, the epoxy group containing cross-linking agent to the epoxy group containing long-chain alkane is 10:4-1:1-4, and the number of carbon atoms of the epoxy group containing long-chain alkane is 6-18. The gel according to the invention has the advantages that on one hand, enzymolysis resistance can be effectively improved, and the gel is more stable; and on the other hand, the excellent intrinsic biocompatibility of the sodium hyaluronate can be maintained, and injectability is unaffected.
D: Disclosed are an injection filling material and a preparation process. The filling material comprises the following raw materials in terms of percentage by mass: 0.1-2% of sodium hyaluronate, 1-30% of polyester microspheres, 0.1-5% of silk fibroin, 0.01-1% of recombinant type III collagen, with the balance being a dispersion liquid. The polyester material is artificially synthesized; the sodium hyaluronate and recombinant protein are prepared by means of a fermentation method; the silk fibroin is extracted from secretions of mulberry silkworms instead of animal tissues, and compared with collagen extracted from animal tissues, a decellularized matrix is biologically safer; and the added polyester microspheres can produce a sustained-release effect on a system, prolong the duration of validity of the filling material, and the filling material lasts longer compared to a single-component material. The filling material comprises type I collagen (silk fibroin), type III collagen (recombinant protein) and a carbohydrate nutrient substance (hyaluronic acid), which are required for tissue production, and can provide a complete external environment for tissue production.
Answer: B