### Clue: Man's house and college spoken of (4)
### Answer: KEYS 
 ### Explanation: Definition: Man's house
Gonville and Caius College, Cambridge, is usually known as just Caius, pronounced "keys". The House of Keys is part of the parliament of the Isle of Man. The intersection of this with LIEBIG in this rather isolated corner might cause a few problems, with three bits of "general knowledge" required