### Clue: Cruelly using Indian's skin over colour, chiefly, they say (10)
### Answer: INHUMANELY 
 ### Explanation: Definition: Cruelly
The "skin" of I[ndia]N + ~~HU[e] ("chiefly" meaning "most of..") + homophone of "mainly"~~ *simpler than that – homophone of "hue mainly"