### Clue: A distraught sob by musician who dislikes Fifty Shades of Grey? (10)
### Answer: ABSOLUTIST 
 ### Explanation: Definition: who dislikes Fifty Shades of Grey?
A charade of 'a' plus BSO, an anagram ('distraught') of 'sob' plus LUTIST (or lutanist or lutenist or luter, 'musician').