### Clue: Why, say, a setter here is disturbed about a Spanish uncle — it's enough to take one's breath away (12)
### Answer: ASPHYXIATION 
 ### Explanation: Definition: it's enough to take one's breath away
anagram of (**y** a Sphinx)*, where **y**="Why, say" and Sphinx="setter here"; around A plus TIO="Spanish [for] uncle"