### Clue: Culmination of attempt to pursue secretary brought about by drugs (6)
### Answer: APOGEE 
 ### Explanation: Definition: Culmination
 **Reversal of**(… brought about) [GO(an attempt/a try) **plus**(to pursue/to chase in a right to left direction) PA(abbrev. for "personal assistant"/a secretary)] **plus**(by) EE(2 x abbrev. for "Ecstasy", the drug).
Defn: …/a climax.