### Clue: 4's 8, right to probe issue, can force changes (6,2,6)
### Answer: TROPIC OF CANCER 
 ### Explanation: Definition: 4's 8
 R(abbrev. for "right") **contained in**(to probe) TOPIC(an issue, under discussion, say) + **anagram of**(… changes) CAN FORCE.
Defn: Work(answer to 8 down);novel by Henry Miller(answer to 4 down).