### Clue: Wearisome fellow at first of Ireland's games nursing a half of Guinness (9)
### Answer: FATIGUING 
 ### Explanation: Definition: Wearisome
 F(abbrev. for "fellow") + AT + [ **the 1st letters, respectively, of**(first of) "Ireland's games" co0(nursing) **the 1st four letters, out of eight, of**(a half of) "Guinness" ].