### Clue: Problem in 8 for possibly blocking sound of 25? (4,3)
### Answer: HOOF ROT 
 ### Explanation: Definition: Problem in 8
 **Anagram of**(… possibly) FOR **contained in**(blocking) HOOT(the sound made by a little owl/answer to 25 across).
Defn: An infection/problem in a horse/a stud/answer to 8 down.