### Clue: US TV celebrity losing heart for fish (4)
### Answer: OPAH 
 ### Explanation: Definition: fish
  "Oprah" Winfrey,US TV talk show host,celebrity **minus** "r",its central letter(losing heart)
Defn:  Aka moonfish or kingfish, a large and colourful deep-sea food fish.  The name is of West African origin.