### Clue: Running nude in street, not giving a hoot (12)
### Answer: UNINTERESTED 
 ### Explanation: Definition: not giving a hoot
  Anagram(*running*) of *NUDE IN STREET*. 
Defn:  *Not giving a* figurative *hoot*.  Another favourite, for its imagery:  nudes of course don't give a figurative hoot when they're running in the street, nor do they have horns to literally hoot at traffic in the street!