### Clue: Lastly, shake anti-viral fluid before opening it (7,8)
### Answer: ITALIAN VERMOUTH 
 ### Explanation: Definition: it
 **Anagram of**(… fluid)[**last letter of**(Lastly) "shake" + ANTI-VIRAL] **placed above**(before, in a down clue) MOUTH(an opening/an entrance to what's inside).
Defn: …, as in the cocktail "gin and it".