### Clue: Freight, having origin in Colchis, on relevant ship? (5)
### Answer: CARGO 
 ### Explanation: Definition: Freight
 **1st letter of**(origin in) "Colchis " **placed above**(on, in a down clue) ARGO(in Greek mythology, the ship on which Jason set out in his quest for Golden Fleece in the ancient country of Colchis – hence "relevant").