### Clue: Posh girl first to be drugged up on cocaine (4-5)
### Answer: HIGH-CLASS 
 ### Explanation: Definition: Posh
 LASS(a girl) **placed below**(first …, in a down clue) [ HIGH(to be drugged up;intoxicated on drugs) **placed above**(on, in a down clue) C(abbrev. for "cocaine") ].