### Clue: In control of a race taking two men over fifty miles (2,3,4)
### Answer: AT THE HELM 
 ### Explanation: Definition: In control
  A + TT(abbrev. for the annual motorcycle $$T$$ourist $$T$$rophy race held on the Isle of Man, or abbrev. for a $$t$$ime $$t$$rial race – take your pick) **plus**(taking) [HE + HE](two x pronoun for a man) **placed above**(over, in a down clue) L(Roman numeral for fifty) + M(abbrev. for $$m$$iles).