### Clue: Van is out at 4.15, popping up everywhere (8)
### Answer: INVASIVE 
 ### Explanation: Definition: popping up everywhere
 **Anagram of**(… out) VAN IS **plus**(at) IV(Roman numeral for 4) + E(I'm guessing here: abbrev. for "east", the direction to which a clock hand showing the 15 minutes past the hour is pointing).