### Clue: 8's pursuit of lover wasted openheart surgery (Madonna had 17,19) (4,3,5)
### Answer: SAVE THE WORLD 
 ### Explanation: Definition: 8's pursuit 
 **Anagram of**(… surgery) [LOVER WASTED + **1st letter of**(open…) "heart"]. And a song hit by the non-Biblical Madonna – "4 minutes(answer to 17 across, 19 down)To ….".
Defn: What Mary's boy child(answer to 8 down) aka Jesus Christ set out to do.