### Clue: Asks for lift from gang? That could be unpleasant! (10)
### Answer: THUMBSCREW 
 ### Explanation: Definition: That could be unpleasant
  THUMBS(asks for a lift from passing vehicles by showing one's thumb; a common practice in innocent days, long gone since) CREW(gang of workers).
Answer:  An instrument that when used on you, will definitely be unpleasant.