### Clue: First sailor to lose a rope at sea hasn't a chance (2-5)
### Answer: NO-HOPER 
 ### Explanation: Definition: hasn't a chance
  NOH{"Noah"(in Genesis, he – and family – was the first human to float,first sailor, in an ark in the great flood, when all the other non-sailors perished) **minus**(to lose) "a"} + **anagram of**(at sea) ROPE.