### Clue: Little girl facing the unknown in a place of great crisis (4)
### Answer: SUEZ 
 ### Explanation: Definition: a place of great crisis
  SUE(short for,little girl's name, Susan) **plus**(facing the) Z(mathematical symbol for an unknown variable, together with siblings x and y).
Answer: The Suez Canal zone was the bone of contention and scene,place of the political and military confrontation,great crisis in 1956.