### Clue: Suffering disease, charge 1's applicator (10)
### Answer: PAINTBRUSH 
 ### Explanation: Definition: 1's applicator
 PAIN(suffering) + TB(abbrev. for "tuberculosis", a bacterial disease, affecting the lungs especially) + RUSH(to charge at;to dash at in an attempt to attack or capture).
Defn: Applicator (of paint) that would be used by Millais;answer to 1 across.