### Clue: Margin for error if rock star mishandled (4,6)
### Answer: RISK FACTOR 
 ### Explanation: Definition: Margin for error
 **Anagram of**(… mishandled) IF ROCK STAR.
Answer: …/something that increases the chances of failure.
I'm not sure if the answer is totally synonymous with the definition which is an error (or errors) you could make but still be able to achieve success.