### Clue: Unrestrained family bull almost blocks big road (6)
### Answer: MEDICI 
 ### Explanation: Definition: Unrestrained family
 "edict"(an example of which is a bull, an official order from the Pope himself) **minus its last letter**(almost) **contained in**(blocks) MI(M1, the north-south expressway;big road in England, with the Roman numeral substituted for "1").
Defn: Powerful;unrestrained family in Italy until 1737.