### Clue: Not most knowledgeable, however (9)
### Answer: LEASTWISE 
 ### Explanation: Definition: however
  LEAST(not most, as an understatement of the littlest) WISE(in the sense of "being wise to",have knowledge of,knowledgeable, and not necessarily having wisdom)
Answer:  I found it quite difficult to illustrate the sense in which the answer and defn. could be used inter-changeably.  This is the best I can do:  "We have not yet won; however/leastwise, we shall keep on trying."  The meaning is "at any rate", "in spite of that"