### Clue: The very best drug contains a hint of temazepam cut with a trace of methadone (7)
### Answer: OPTIMUM 
 ### Explanation: Definition: The very best
 [ OPIUM(a drug from poppy pods) **containing**(contains) **the 1st letter of**(a hint of) "temazepam " ] **containing**(cut with) **the 1st letter of**(a trace of) "methadone ".