Update README.md

README.md

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----
-license: apache-2.0
----
+---
+license: apache-2.0
+pipeline_tag: image-feature-extraction
+tags:
+- medical
+- cardiac MRI
+- MRI
+- CINE
+- dynamic MRI
+- representation learning
+- unsupervised learning
+- 3D
+- diffusion
+- diffusion autoencoder
+- autoencoder
+- DiffAE
+- 3D DiffAE
+- UK Biobank
+- latent space
+library_name: pytorch
+---
+# UKBBLatent_Cardiac_20208_DiffAE3D_L128_S42
+
+Biobank-scale imaging provides a unique opportunity to characterise structural and functional cardiac phenotypes and how they relate to disease outcomes. However, deriving specific phenotypes from MRI data requires time-consuming expert annotation, limiting scalability and does not exploit how information dense such image acquisitions are. In this study, we applied a 3D diffusion autoencoder to temporally resolved cardiac MRI data from 71,021 UK Biobank participants to derive latent phenotypes representing the human heart in motion. These phenotypes were reproducible, heritable (h2 = [4 - 18%]), and significantly associated with cardiometabolic traits and outcomes, including atrial fibrillation (P = 8.5 × 10-29) and myocardial infarction (P = 3.7 × 10-12). By using latent space manipulation techniques, we directly interpreted and visualised what specific latent phenotypes were capturing in a given MRI. 
+
+## Model Details
+
+During this research, the original [DiffAE](https://diff-ae.github.io/) model was adapted and extended for 3D to create the 3D DiffAE model, and was trained on the CINE Cardiac Long-axis 4-chamber view MRIs from UK Biobank dataset using 5 different seeds. This model can be used to infer latent representations from similar cardiac MRIs, or can also be used as pretrained models and then fine-tuned on other datasets or tasks. 
+This model can also be used to generate synthetic cardiac MRIs similar to the training set. 
+
+### Model Description
+
+- **Model type:** 3D DiffAE
+- **Task:** Obtaining latent representation from 3D input volumes
+- **Training dataset:** [CINE Cardiac Long-axis 4-chamber view MRIs from UK Biobank](https://biobank.ctsu.ox.ac.uk/crystal/field.cgi?id=20208)
+- **Training seed:** 42
+- **Input:** 3D MRI (2D over time), intensity normalised (min-max, followed by z-score with 0.5 mean and std)
+- **Output:** 128 latent factors. Can also be used for generating synthetic MRIs.
+
+### Model Sources
+
+<!-- Provide the basic links for the model. -->
+
+- **Repository:** https://github.com/GlastonburyGroup/ImLatent
+- **Project page:** https://glastonburygroup.github.io/CardiacDiffAE_GWAS/
+- **Preprint:** https://doi.org/10.1101/2024.11.04.24316700
+
+## Citation
+
+<!-- If there is a paper or blog post introducing the model, the APA and Bibtex information for that should go in this section. -->
+
+If you use this model in your research, or utilise code from this repository or the provided weights, please consider citing the following in your publications:
+
+**BibTeX:**
+
+```bibtex
+@article{Ometto2024.11.04.24316700,
+            author       = {Ometto, Sara and Chatterjee, Soumick and Vergani, Andrea Mario and Landini, Arianna and Sharapov, Sodbo and Giacopuzzi, Edoardo and Visconti, Alessia and Bianchi, Emanuele and Santonastaso, Federica and Soda, Emanuel M and Cisternino, Francesco and Ieva, Francesca and Di Angelantonio, Emanuele and Pirastu, Nicola and Glastonbury, Craig A},
+            title        = {Unsupervised cardiac MRI phenotyping with 3D diffusion autoencoders reveals novel genetic insights},
+            elocation-id = {2024.11.04.24316700},
+            year         = {2024},
+            doi          = {10.1101/2024.11.04.24316700},
+            publisher    = {Cold Spring Harbor Laboratory Press},
+            url          = {https://www.medrxiv.org/content/early/2024/11/05/2024.11.04.24316700},
+            journal      = {medRxiv}
+          } 
+```
+
+**APA:**
+
+Ometto, S., Chatterjee, S., Vergani, A. M., Landini, A., Sharapov, S., Giacopuzzi, E., … Glastonbury, C. A. (2024). Unsupervised cardiac MRI phenotyping with 3D diffusion autoencoders reveals novel genetic insights. medRxiv. doi:10.1101/2024.11.04.24316700