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Which of the following will cause oral cancers?

Syphilitic glossitis

EBV

НPV

All of the above

Route of choice for analgesics in cancer patients

Oral

IV

Topical

Sublingual

A 55 years old female presented with breast mass of size 3 cm with ulceration, edema and satellite nodules confined to the same breast with metastasis to ipsilateral axillary lymph node I & II and is mobile on examination. The staging of the breast cancer is:

Stage II B

Stage III A

Stage III B

Stage IV

Antifungal used as cancer chemo therapeutic agent is?

Flucytosine

Nystatin

Voriconazole

Terbinafine

Rattan, a middle-aged man is chronically preoccupied with his health. For many years he feared that his irregular bowel functions meant he had cancer. Now he is very preoccupied about having a serious hea disease, despite his physician's assurance that the occasional "extra beats" he detects when he checks his pulse are completely benign. What is his most likely diagnosis?

Somatization disorder

Hypochondriasis

Delusional disorder

Pain disorder

Tumor Suppressor Gene associated with Familial gastric cancer and Lobular breast carcinoma is

RB

PTEN

APC

CDH1

Route of administration of BCG for bladder cancer is :

Oral

Subcutaneous

Intravenous

None of the above

A 58-year-old woman undergoes lumpectomy for breast cancer. One month following surgery, she notices a firm 0.3-cm nodule along one edge of the surgical incision. Biopsy of this nodule reveals chronic inflammatory cells, multinucleated giant cells, and extensive fibrosis. The multinucleated cells in this nodule most likely formed in response to which of the following pathogenic stimuli?

Staphylococcal infection

Foreign material

Lymphatic obstruction

Neoplastic cells

A 67-year-old man with lung cancer notices symptoms of weakness in his arms and legs. He describes difficulty in rising out of chair or going upstairs, but no pain or discomfort. On examination, proximal muscle strength is four out of five in the upper and lower limbs, but the reflexes, tone, and sensation are normal. He has a colored rash on his eyelids, and raised papules on his knuckles.For the above patient with muscle weakness, select the most likely anatomic site for the disorder

anterior horn cell

peripheral nerve

neuromuscular junction

muscle

Treatment of choice for cancer head of pancreas?

Radiotherapy

Chemotherapy + Radiotherapy

Whipple's surgery

Resection of the entire pancreas with adjuvant chemotherapy

Alcohol abuse is associated with an increased risk of all the following types of cancer EXCEPT:

Breast

Esophageal

. Liver

Cervical

Drug of choice for Neutropenia due to cancer chemotherapy is -

Vitamin B-12

IL 11

Filgrastim

Erythropoietin

Occupational cancer involve following organs except?

Lung

Breast

Bladder

Skin

Most common site for colorectal cancer is

Rectum

Anal canal

Spleenic flexure

Appendix

Which of the following is not a precancerous condition to colon -

Irritable bowel syndrome

Ulcerative colitis

Familial polyposis

All

True about occupational cancers -a) Seen even after exposure is stoppedb) Site for occurance common to occupationc) Usually not seen in younger personsd) Scrotal cancer is common in dye industry workers

ac

a

ad

ab

Commonest cancer in a renal transplant recipient is

Kaposi sarcoma

Renal cell carcinoma

Ca cervix

Skin cancer

A 50-year-old male, working as a hotel cook, has four dependent family members. He has been diagnosed with an early stage squamous cell cancer of the anal canal. He has more than 60% chances of cure. The best treatment option is

Abdomino-perineal resection

Combined surgery and radiotherapy

Combined chemotherapy and radiotherapy

Chemotherapy alone

A 49 year old man suffering from carcinoma of prostate was x -rayed. He showed areas of sclerosis and collapse of T 10 and T11 veebrae in x-ray. The spread of this cancer to the above veebrae was through -

Sacral canal

Lymphatic vessels

Internal veebral plexus of veins

Superior rectal vein

A man with intermittent hiccups feels that he is about to die because he is suffering from gastric cancer. All his radiological investigations prove the contrary. Which is the most probable diagnosis?

Hypochondriasis

Somazaon disorder

Conversion disorder

Delusional disorder

A 15-year-old boy is injured while playing cricket. X-rays of the leg rule out of a possible fracture. The radiologist repos the boy has an evidence of aggressive bone tumor with both bone destruction and soft tissue mass. The bone biopsy reveals a bone cancer with neural differentiation. Which of the following is the most likely diagnosis?

Chondrablastoma

Ewing's sarcoma

Neuroblastoma

Osteosarcoma

Triple negative breast cancer - True statement is

It has good prognosis

There are no receptors positive for ER, PR and HER2 NEU

It is a cancer that cannot be diagnosed by triple assessment

Three radiologic investigations i.e CT scan, MRI and USG are needed for diagnosis

Least malignant thyroid cancer is -

Papillary carcinoma

Follicular carcinoma

Medullary carcinoma

Anaplastic carcinoma

Patient with HNPCC (hereditary nonpolyposis colon cancer) has genes with microsatellite instability. This is due to failure of which repair mechanism of DNA

Mismatch repair

Base excision repair

Homologous end joining repair

Non homologous end joining repair

Sensitivity of conventional PAP smear in picking up cervical cancer is: September 2007

70%

80%

90%

100%

Which of the following strategy has been recommended to reduce the heredity risk for ovarian cancer in women with BRCA - 1 and BRCA - 2 mutations:

Use of oral contraceptive pills

Screening with transvaginal ultrasound

Screening with CA - 125

Prophylactic oophorectomy

Smoking predisposes to all of the following cancers EXCEPT: September 2012

Carcinoma larynx

Carcinoma bladder

Carcinoma esophagus

Lymphoma

Gynaecological cancer unusual in young women:

Cancer ovary

Cancer cervix

Cancer vulva

Choriocarcinoma

Most common site of cancer penis:

Glans penis

Prepuce

Shaft

Coronal Sulcus

Most common oral cancer;

Squamous cell ca

Adenocarcinoma

Transition cell ca

Mucoepidermoid

Which is the most common gene mutation responsible for the following thyroid cancer?

Ret

Ras

P53

BRAF

Most emetogenic anticancer drug is:

Cisplatin

Carboplatin

High dose cyclophosphamide

High dose methotrexate

A 50 yr. old woman underwent debulking surgery for advanced epithelial ovarian cancer. What standard adjuvant therapy would be recommended for this woman?

Paclitaxel and carboplatin for six cycles

Paclitaxel and carboplatin for six cycles and radiotherapy

Paclitaxel for six cycles and radiotherapy

Radiotherapy alone

BRCA 1 responsible which histological type breast cancer?

Tubular carcinoma

Colloid carcinoma

Papillary carcinoma

Medullary carcinoma

All of the following are premalignant lesions of oral cavity cancer except

Erythroplakia

Proliferative verrucous leukoplakia

Chronic hyperplastic candidiasis

Desquamative gingivitis

Grading of cancer based on ?

Differentiation

Tumor necrosis

Tumor size

Lymph node status

Virus associated with cancer cervix :

HPV

HIV

EBV

HTLV

MC HPV Type which causes cervical cancer -

6

11

16

18

Anticancer drug(s) which does/do not suppress bone marrow ?

5-FU

Cisplatin

Chlorambucil

Vincristine

What should be the plan of patient who undergoes Laparoscopic cholecystectomy, specimen showed T2 Gallbladder Cancer?

Relaparotomy and resect Segment 4b - 5, dissection of N1-2 nodes with port sites

Post op Chemotherapy alone

Extended Cholecystectomy

Whipple procedure

Cancerous involvement is seen with

Chancre

Mucous patch

Syphilitic glossitis

Gumma

Which of the following for pain control in terminally ill cancer patients

Pethidine

Fentanyl

Methodone

Remifentanyl

A 57-year-old woman presents to a physician with chronic pelvic pain of many years duration. On fuher questioning, the woman also repos urinary frequency, constipation, pain with intercourse and bloating. On physical examination, a large mass is felt in the pelvic area. Follow-up ultrasound examination demonstrates that the mass involves the right adnexa and is composed of multiloculated cystic spaces. Prior to sending the patient to surgery, the primary care physician wants to order a serum tumor marker to screen for ovarian cancer. Which of the following would be the best choice?

Adrenocoicotropic hormone

CA-125

Galactosyltransferase

S-100

Best investigation for prostate cancer is -

Prostate Specific Antigen

Acid Phosphatse

PSA velocity

Alkaline phosphatase

In which of the following head and neck cancers, is lymph node metastasis least common?

Tongue

Buccal mucosa

Hard palate

Lower alveolus

Least malignant thyroid cancer is:

Papillary carcinoma

Follicular carcinoma

Medullary carcinoma

Anaplastic carcinoma

A 40-year-old patient is diagnosed with a localized 1 cm infiltrating ductal cancer after a needle core biopsy of the lesion. She is clinical node negative; a lumpectomy and sentinel lymph node biopsy are performed. The patient develops an anaphylactic response during the case. Which of the following substances was the likely causative agent?

Fluorescein

99 Tc radiolabeled colloid

Isosulfan blue dye

Methylene blue dye

Most common malignant cancer of conjunctiva

Squamous cell carcinoma

Basal cell carcinoma

Dermoid

Papilloma

Which anticancer drug inhibits dihydrofolate reductase?

Vincristine

Methotrexate

Paclitaxel

Cisplatin

Lymphatic spread is most commonly seen with which type of thyroid cancer -

Medullary

Papillary

Follicular

Lymphoma

Most common cancer of anus?

Squamous

Basaloid

Cuboidal

Cloacogenic

Cells cultured from patients with this disorder exhibit low activity for the nucleotide excision repair process. This autosomal recessive genetic disease includes marked sensitivity to sunlight (Ultra voilet light) with subsequent formation of multiple skin cancers and premature death, the disorder is:

Acute intermittent Porphyria

Alkaptonuria

Xeroderma Pigmentosa

Ataxia - Telangiectasa

A 60-year-old male presents with Cancer prostate. The tumor is limited to the capsule and it is palpable on PR examination. The patient is diagnosed as stage T1b. The best treatment would be:

Radical prostatectomy

Chemotherapy

Palliative radiotherapy

Orchidectomy

Which one of the following is not a premalignant condition for colon cancer?

Familial adenomatous polyposis coli

Villous adenoma

Ulcerative colitis

Hamaomatous polyps

Regarding the established risk factors for breast cancer, all are true, EXCEPT:

Occurrence in Indian women is about a decade earlier than in western women

Breast cancer is common in higher socioeconomic groups

Prior breast biopsy of benign breast disease is associated with a decreased risk of Ca breast

40 or more years of menstruation doubles the risk of Ca breast as compared with 30 years

Which of the following cancer metastasize to brain leastly: March 2011

Hypernephroma

Breast carcinoma

Choriocarcinoma

Prostatic carcinoma

A patient with oral cancer involving mandible is managed by:

Chemotherapy alone

Radiotherapy alone

Resection followed by radiotherapy

Radiotherapy followed by resection

All the following can cause GIT cancers except

Hepatitis B virus

EBV

HIV

H. pylori

Tumor markers of ovarian cancer is-

CA125

CA19-9

AFP

hCG

Histological appearance of which uterine cancer resembles epithelial ovarian cancer

Clear cell carcinoma

Uterine papillary serous carcinoma

Endometroid adenocarcinoma

Mucinous carcinoma

Germline mutations in which of the following genes is not associated with hereditary breast cancer?

CHEK2

GATA2

BRCA2

TP53

Best prognosis of all thyroid cancers:

Papillary

Follicular

Medullary

Anaplastic

Prostate Cancer spreads to the vertebral column via?

a Batson plexus

b Inferior hypogastric plexus

c Superior hypogastric plexus

d All of above

In which of the following is medullary thyroid cancer is the most aggressive form

MEN type I

MEN type II a

MEN type II b

Sporadic cases

Bilateral ovarian cancer with; capsule breached; ascites positive for malignant cells. Stage is;

l

ll

Ill

lV

True about national program for prevention and control programme of cancer, diabetes, cardiovascular diseases and stroke is ?

Home based care is not given

Implementation in some 5 states over 10 districts

Separate centre for storke, DM

CHC has facilities for diagnosis and treatment of CVD diabetes

In a case control study on smoking and lung cancer, out of 35 lung cancer patients, 33 are smokers. Out of 82 controls, 27 are non smokers. Find the odds ratio:

0.21

8.1

4.1

2.1

All are true about cancers during pregnancy, except:

Cancer develops during ~1 in every 1000 pregnancies.

Of all the cancers that occur in women, less than 1% seen in pregnant ladies

The four cancers most commonly developing during pregnancy are cervical cancer, breast cancer, melanoma, and lymphoma (usually Hodgkin's lymphoma)

Lymphoma is the most common cancer during pregnancy

In rectal cancer, the distal clearance margin should be at least

2 cm

3cm

4 cm

5 cm

A 54-year-old woman who has been diagnosed with early-stage breast cancer undergoes surgery for a lumpectomy to remove a small tumor detected by mammography. the pathology repo confirms early stage of the cancer and fuher comments on the fact that there is significant desmoplasia in the surrounding tissue. The term desmoplasia refers to

an irregular accumulation of blood vessels.

Scanty connective tissue causing the neoplasm to be soft and fleshy.

normal tissue misplaced within another organ

proliferation of non-neoplastic fibrous connective tissue

Stage T1NOMO in breast cancer indicates-

Tumor more than 2 ems in diameter without axillary nodes and absent metastasis

Tumour 2 cms or less without axillary nodes and no metastasis

Tumour fixed to the chest wall without axillary nodes or distant metastasis

Tumour fixed to the underlying muscle with no nodes in axilla but wth distant metastasis

Which organism is associated with causation of urinary bladder cancer -

E. coli

Paragonimus

Schistosoma

Clonorchis

A 55-year-old woman requires an abdominoperineal operation for rectal cancer. She has a history of stable angina. Which of the following clinical markers is most likely to predict a cardiac event during her noncardiac surgery and should prompt fuher cardiac workup prior to her operation?

Abnormal electrocardiogram

Prior stroke

Unstable angina

Uncontrolled hypeension

A 40 year old female presenting with a slow growing painless mass is recently diagnosed to have thyroid cancer. Which is the most common subtype of thyroid cancer?

Medullary carcinoma

Papillary carcinoma

Follicular carcinoma

Anaplastic carcinoma

All the following drugs are used in the treatment of metastatic breast cancer except:

Ixabepilone

Abemaciclib

Ribociclib

Sunitinib

Antifolate cancer drugs are: (PGI Nov 2009)

Methotrexate

Azathioprine

Cyclosporin

Vincristne

A 74-year-old woman presents to the clinic for evaluation of increasing back pain and malaise. The symptoms are insidious in onset and she reports no history of recent trauma to the back. Her past medical history is significant for hypertension and breast cancer which was diagnosed 7 years ago and treated with surgery and adjuvant therapy.On physical examination, the pertinent findings are percussion tenderness over the lower spine. An x-ray of the lumbar spine reveals lytic lesions compatible with metastatic bone disease, and her serum calcium level is elevated. Which of the following mediators is least likely to be involved?

interleukin-6 (IL-6)

ectopic parathyroid hormone (PTH)

tumor necrosis factor (TNF)

interleukin-1 (IL-1)

A 60-year-old lady comes with blood stained discharge from the nipple with family history of breast cancer. Next best step for her will be:

Ductoscopy

Sonomammogram

Nipple discharge cytology

MRI

A 78-year-old man has carcinoma of the rectum. The cancer is likely to metastasize the veins into which of the following structures?

Spleen

Kidney

Liver

Duodenum

'N3' in Head & Neck cancer TNM staging refers to

Ipsilateral lymph node 3-6 cm

Contralateral lymph node 3-6 cm

Bilateral lymph nodes 3-6 cm

Contralateral lymph node > 6 cm

A patient with previously diagnosed lung cancer develops a large pleural effusion. The effusion is tapped and demonstrates an unusual milky white fluid that upon standing, separates into a thin white layer over a thicker clear layer. The lipid content of the fluid is high. This is most likely an example of which of the following?

Chylous effusion

Exudate

Fibrinous pleuritis

Fibrous pleuritis

Among the following, the least malignant potential for colorectal cancer is seen in polyps associated with?

Gardner's Syndrome

Turcot's Syndrome

Peutz Jagher's Syndrome

FAP

All are true about pancreatic cancer, EXCEPT:

It is usually associated with poor prognosis

Most frequent site is in the head of the pancreas

90 % cases are inoperable at the time of the diagnosis

5 year survival is 40 %

Which of the following anticancer drugs are competitive inhibitors of tyrosine kinase?

Imatinib and Sunitnib

Letrozole

Bicalutamide

Fulvestrant

what is the cause of Most common bone cancer among young men is

Chondrosarcoma

Ewing sarcoma

Osteosarcoma

Giant cell tumor

All are true statements about anticancer drugs except?

Vincristine is a marrow sparing anticancer drug

Irinotecan is a topoisomerase II inhibitor

L-asparaginase can cause acute pancreatitis

Anthracyclines cause cardiotoxicity

Aspirin is given in management of which cancer:

Pancreatic cancer

Liver cancer

Colon cancer

Stomach cancer

All of the following anticancer agents cause bone marrow suppression EXCEPT :

Chlorambucil

Daunorubicin

Doxorubicin

Flutamide

A 60 year old lady comes with blood stained discharge from the nipple with family history of breast cancer. Next best step for her will be

Ductoscopy

Nipple discharge cytology

Sono-mammogram

MRI

A male aged 40 years presenting with papillary cancer thyroid confined to one lobe of thyroid of size 3x3 cm with no node palpable. What is the ideal treatment?

Hemithyroidectomy

Subtotal Thyroidectomy

Total thyroidectomy with Nodal Dissection

Total thyroidectomy

The role of Tamoxifen in the reduction of breast cancer is

Competes with estrogen receptor in breast

Decreases blood supply to tumour

Directly acting anticancer drug

Augments radiation therapy

True about small cell lung cancer

Bone marrow is uncommonly involved

Destruction of alveolar cells

Peripheral in location

All

Management of febrile neutropenic patients on anti-cancer therapy include all except:

Colony stimulating factors

Transfusion of granulocytes

Antibiotic Prophylaxis

Repeated hand washing

In cervical cancer surgery is limited to patients with

Stage I to IIA

Stage I to IIB

Stage I to IIIA

Stage I to IIIB

Corpus cancer syndrome is characterized by following except NOT RELATED-MEDICINE

Diabetes

Obesity

Multiparity

Hypeension

A Child with kidney transplant developed lymphoproliferative cancer. The most common virus implicated is:

CMV

Varicella

HPV

EBV

A patient with cancer received extreme degree of radiation toxicity. Further history revealed that the dose adjustment of a particular drug was missed during the course of radiotherapy. Which of the following drugs required a dose adjustment in that patient during radiotherapy in order to prevent radiation toxicity –

Vincristine

Dactinomycin

Cyclophosphamide

6 – Mercaptopurine

Most common site of gastric cancer is:

Lesser curvature of stomach

Greater curvature of stomach

Fundus

Antrum

Subcapsular orchiectomy is done for cancer of -

Testes

Prostate

Penis

Urethra

Histopatholoty of a lung cancer shows 'clara cells' probable diagnosis is ?

Squamous cell cancer

Bronchio alveolar cancer

Large cell cancer

Papillary carcinoma