id
stringlengths
7
11
context
stringlengths
24
527
is_mult_event
bool
2 classes
annotations
list
10452772_4
Patients receiving neutral protamine Hagedorn (NPH) insulin are at increased risk for the development of protamine hypersensitivity.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"development\"]], \"start\": [[90]], \"entity_id\": [\"T5\"]}, \"Effect\": {\"text\": [[\"protamine hypersensitivity\"]], \"start\": [[105]], \"entity_id\": [\"T4\"]}, \"Subject\": {\"text\": [[\"Patients\"]], \"start\": [[0]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"neutral protamine Hagedorn (NPH) insulin\"]], \"start\": [[19]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"neutral protamine Hagedorn (NPH) insulin\"]], \"start\": [[19]], \"entity_id\": [\"T7\"]}}, \"Severity\": {\"text\": [[\"increased risk\"]], \"start\": [[67]], \"entity_id\": [\"T8\"], \"value\": \"Medium\"}}" } ] } ]
8053440_3
The second patient, who developed cholestasis after receiving trimethoprim-sulfamethoxazole, had marked duct paucity in the liver biopsy.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[24]], \"entity_id\": [\"T6\"]}, \"Subject\": {\"text\": [[\"The second patient\"]], \"start\": [[0]], \"entity_id\": [\"T5\"]}, \"Effect\": {\"text\": [[\"cholestasis\", \"duct paucity\"]], \"start\": [[34, 104]], \"entity_id\": [\"T7\"]}, \"Treatment\": {\"text\": [[\"trimethoprim-sulfamethoxazole\"]], \"start\": [[62]], \"entity_id\": [\"T8\"], \"Drug\": {\"text\": [[\"trimethoprim-sulfamethoxazole\"]], \"start\": [[62]], \"entity_id\": [\"T9\"]}}}" } ] } ]
9191742_2
We describe a patient who became hypothyroid while taking ferrous sulfate.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"became\"]], \"start\": [[26]], \"entity_id\": [\"T5\"]}, \"Effect\": {\"text\": [[\"hypothyroid\"]], \"start\": [[33]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"ferrous sulfate\"]], \"start\": [[58]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"ferrous sulfate\"]], \"start\": [[58]], \"entity_id\": [\"T7\"]}}, \"Subject\": {\"text\": [[\"a patient\"]], \"start\": [[12]], \"entity_id\": [\"T6\"]}}" } ] } ]
16540070_2
Allergy to cloxacillin with normal tolerance to amoxicillin and cefuroxime.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"to\"]], \"start\": [[8]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"Allergy\"]], \"start\": [[0]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"cloxacillin\"]], \"start\": [[11]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"cloxacillin\"], [\"amoxicillin\"], [\"cefuroxime\"]], \"start\": [[11], [48], [64]], \"entity_id\": [\"T6\", \"T7\", \"T8\"]}}}" } ] } ]
1642627_2
Triazolam-induced nocturnal bingeing with amnesia.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[10]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"Triazolam\"]], \"start\": [[0]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"Triazolam\"]], \"start\": [[0]], \"entity_id\": [\"T9\"]}}, \"Effect\": {\"text\": [[\"nocturnal bingeing with amnesia\"]], \"start\": [[18]], \"entity_id\": [\"T7\"]}}" } ] } ]
12221670_3
Ticlopidine-induced aplastic anemia (TIAA) is considered very uncommon.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[12]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"Ticlopidine\"]], \"start\": [[0]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"Ticlopidine\"]], \"start\": [[0]], \"entity_id\": [\"T9\"]}}, \"Effect\": {\"text\": [[\"aplastic anemia (TIAA)\"]], \"start\": [[20]], \"entity_id\": [\"T7\"]}, \"Speculated\": {\"text\": [[\"uncommon\"]], \"start\": [[62]], \"entity_id\": [\"T8\"], \"value\": true}}" } ] } ]
14998226_9
One case report describes an interaction between simvastatin and the anticoagulant acenocoumarol, which resulted in an elevated INR.
true
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"resulted\"]], \"start\": [[104]], \"entity_id\": [\"T7\"]}, \"Treatment\": {\"text\": [[\"simvastatin and the anticoagulant acenocoumarol\"]], \"start\": [[49]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"simvastatin\"], [\"anticoagulant acenocoumarol\"]], \"start\": [[49], [69]], \"entity_id\": [\"T11\", \"T12\"]}, \"Combination\": [{\"event_id\": \"E2\", \"event_type\": \"Combination\", \"Trigger\": {\"text\": [[\"and\"]], \"start\": [[61]], \"entity_id\": [\"T13\"]}, \"Drug\": {\"text\": [[\"simvastatin\"], [\"anticoagulant acenocoumarol\"]], \"start\": [[49], [69]], \"entity_id\": [\"T11\", \"T12\"]}}]}, \"Effect\": {\"text\": [[\"elevated INR\"]], \"start\": [[119]], \"entity_id\": [\"T8\"]}, \"Subject\": {\"text\": [[\"One case\"]], \"start\": [[0]], \"entity_id\": [\"T9\"], \"Population\": {\"text\": [[\"One\"]], \"start\": [[0]], \"entity_id\": [\"T10\"]}}}" } ] } ]
16884425_1
A 35-year-old woman presented with neurotoxicity correlated to an i.v. regimen of 5-fluorouracil as episodes of acute confusional state and abnormalities of symmetrically restricted diffusion in the periventricular white matter and corpus callosum.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"correlated\"]], \"start\": [[49]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"an i.v. regimen of 5-fluorouracil\"]], \"start\": [[63]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"5-fluorouracil\"]], \"start\": [[82]], \"entity_id\": [\"T11\"]}, \"Route\": {\"text\": [[\"i.v.\"]], \"start\": [[66]], \"entity_id\": [\"T12\"]}}, \"Effect\": {\"text\": [[\"neurotoxicity\", \"acute confusional state and abnormalities of symmetrically restricted diffusion in the periventricular white matter and corpus callosum\"]], \"start\": [[35, 112]], \"entity_id\": [\"T7\"]}, \"Subject\": {\"text\": [[\"A 35-year-old woman\"]], \"start\": [[0]], \"entity_id\": [\"T8\"], \"Age\": {\"text\": [[\"35-year-old\"]], \"start\": [[2]], \"entity_id\": [\"T9\"]}, \"Gender\": {\"text\": [[\"woman\"]], \"start\": [[14]], \"entity_id\": [\"T10\"]}}}" } ] } ]
3947272_2
Ampicillin may aggravate clinical and experimental myasthenia gravis.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"aggravate\"]], \"start\": [[15]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"Ampicillin\"]], \"start\": [[0]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"Ampicillin\"]], \"start\": [[0]], \"entity_id\": [\"T6\"]}}, \"Effect\": {\"text\": [[\"myasthenia gravis\"]], \"start\": [[51]], \"entity_id\": [\"T5\"]}, \"Speculated\": {\"text\": [[\"may\"]], \"start\": [[11]], \"entity_id\": [\"T7\"], \"value\": true}}" } ] } ]
8586895_2
In the present paper, we discuss the first Japanese vivax malaria patient whose QT interval was prolonged after treatment with halofantrine.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"after\"]], \"start\": [[106]], \"entity_id\": [\"T6\"]}, \"Subject\": {\"text\": [[\"Japanese vivax malaria patient\"]], \"start\": [[43]], \"entity_id\": [\"T3\"], \"Race\": {\"text\": [[\"Japanese\"]], \"start\": [[43]], \"entity_id\": [\"T7\"]}}, \"Treatment\": {\"text\": [[\"halofantrine\"]], \"start\": [[127]], \"entity_id\": [\"T4\"], \"Disorder\": {\"text\": [[\"vivax malaria\"]], \"start\": [[52]], \"entity_id\": [\"T8\"]}, \"Drug\": {\"text\": [[\"halofantrine\"]], \"start\": [[127]], \"entity_id\": [\"T9\"]}}, \"Effect\": {\"text\": [[\"QT interval was prolonged\"]], \"start\": [[80]], \"entity_id\": [\"T5\"]}}" } ] } ]
1772299_2
The Center for Disease Control has received numerous reports of an eosinophilia-myalgia syndrome related to products containing L-tryptophan.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"related\"]], \"start\": [[97]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"products containing L-tryptophan\"]], \"start\": [[108]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"L-tryptophan\"]], \"start\": [[128]], \"entity_id\": [\"T6\"]}}, \"Effect\": {\"text\": [[\"eosinophilia-myalgia syndrome\"]], \"start\": [[67]], \"entity_id\": [\"T4\"]}}" } ] } ]
6998294_2
Disopyramide (Norpace)-induced hypoglycemia.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[23]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"Disopyramide (Norpace)\"]], \"start\": [[0]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"Disopyramide\"]], \"start\": [[0]], \"entity_id\": [\"T7\"]}}, \"Effect\": {\"text\": [[\"hypoglycemia\"]], \"start\": [[31]], \"entity_id\": [\"T6\"]}}" } ] } ]
3195622_1
A case report of the hypersensitivity syndrome occurring in a patient being treated with dapsone for a brown recluse spider bite is presented.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"treated\"]], \"start\": [[76]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"dapsone\"]], \"start\": [[89]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"dapsone\"]], \"start\": [[89]], \"entity_id\": [\"T7\"]}, \"Disorder\": {\"text\": [[\"brown recluse spider bite\"]], \"start\": [[103]], \"entity_id\": [\"T8\"]}}, \"Effect\": {\"text\": [[\"hypersensitivity syndrome\"]], \"start\": [[21]], \"entity_id\": [\"T5\"]}, \"Subject\": {\"text\": [[\"a patient\"]], \"start\": [[60]], \"entity_id\": [\"T6\"]}}" } ] } ]
17324248_1
AIMS: To present a case of piloerection after replacing fluvoxamine maleate with milnacipran hydrochloride, and to analyse this effect based on receptor occupancy theory.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"after\"]], \"start\": [[40]], \"entity_id\": [\"T6\"]}, \"Effect\": {\"text\": [[\"piloerection\"]], \"start\": [[27]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"fluvoxamine maleate\"]], \"start\": [[56]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"fluvoxamine maleate\"], [\"milnacipran hydrochloride\"]], \"start\": [[56], [81]], \"entity_id\": [\"T7\", \"T8\"]}}}" } ] } ]
18171260_4
Serotonin syndrome after concomitant linezolid and meperidine therapy has not been described.
true
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"after\"]], \"start\": [[19]], \"entity_id\": [\"T7\"]}, \"Effect\": {\"text\": [[\"Serotonin syndrome\"]], \"start\": [[0]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"linezolid and meperidine\"]], \"start\": [[37]], \"entity_id\": [\"T8\"], \"Drug\": {\"text\": [[\"linezolid\"], [\"meperidine\"]], \"start\": [[37], [51]], \"entity_id\": [\"T9\", \"T11\"]}, \"Combination\": [{\"event_id\": \"E2\", \"event_type\": \"Combination\", \"Trigger\": {\"text\": [[\"concomitant\"]], \"start\": [[25]], \"entity_id\": [\"T10\"]}, \"Drug\": {\"text\": [[\"linezolid\"], [\"meperidine\"]], \"start\": [[37], [51]], \"entity_id\": [\"T9\", \"T11\"]}}]}, \"Negated\": {\"text\": [[\"not\"]], \"start\": [[74]], \"entity_id\": [\"T12\"], \"value\": true}}" } ] } ]
23868369_4
She presented to clinic with nausea and anorexia within a few days of addition of ciprofloxacin to her current regimen of medications, which included digoxin.
true
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"presented\"]], \"start\": [[4]], \"entity_id\": [\"T8\"]}, \"Treatment\": {\"text\": [[\"addition of ciprofloxacin to her current regimen of medications, which included digoxin\"]], \"start\": [[70]], \"entity_id\": [\"T9\"], \"Time_elapsed\": {\"text\": [[\"within a few days\"]], \"start\": [[49]], \"entity_id\": [\"T13\"]}, \"Drug\": {\"text\": [[\"ciprofloxacin\"], [\"digoxin\"]], \"start\": [[82], [150]], \"entity_id\": [\"T14\", \"T15\"]}, \"Combination\": [{\"event_id\": \"E2\", \"event_type\": \"Combination\", \"Trigger\": {\"text\": [[\"addition\"]], \"start\": [[70]], \"entity_id\": [\"T16\"]}, \"Drug\": {\"text\": [[\"ciprofloxacin\"], [\"digoxin\"]], \"start\": [[82], [150]], \"entity_id\": [\"T14\", \"T15\"]}}]}, \"Effect\": {\"text\": [[\"nausea and anorexia\"]], \"start\": [[29]], \"entity_id\": [\"T10\"]}, \"Subject\": {\"text\": [[\"She\"]], \"start\": [[0]], \"entity_id\": [\"T11\"], \"Gender\": {\"text\": [[\"She\"]], \"start\": [[0]], \"entity_id\": [\"T12\"]}}}" } ] } ]
15379082_1
Disulfiram-induced fulminant hepatic failure in an active duty soldier.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[11]], \"entity_id\": [\"T5\"]}, \"Subject\": {\"text\": [[\"an active duty soldier\"]], \"start\": [[48]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"Disulfiram\"]], \"start\": [[0]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"Disulfiram\"]], \"start\": [[0]], \"entity_id\": [\"T7\"]}}, \"Effect\": {\"text\": [[\"fulminant hepatic failure\"]], \"start\": [[19]], \"entity_id\": [\"T6\"]}}" } ] } ]
8530331_2
BACKGROUND: We report six cases of psychosis in patients with akinetic-rigid syndromes who were treated with risperidone.
false
[ { "events": [ { "event_id": "E1", "event_type": "Potential_therapeutic_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Potential_therapeutic_event\", \"Trigger\": {\"text\": [[\"treated\"]], \"start\": [[96]], \"entity_id\": [\"T9\"]}, \"Subject\": {\"text\": [[\"six cases\", \"patients with akinetic-rigid syndromes\"]], \"start\": [[22, 48]], \"entity_id\": [\"T7\"], \"Population\": {\"text\": [[\"six\"]], \"start\": [[22]], \"entity_id\": [\"T11\"]}, \"Disorder\": {\"text\": [[\"akinetic-rigid syndromes\"]], \"start\": [[62]], \"entity_id\": [\"T12\"]}}, \"Treatment\": {\"text\": [[\"risperidone\"]], \"start\": [[109]], \"entity_id\": [\"T10\"], \"Disorder\": {\"text\": [[\"psychosis\"]], \"start\": [[35]], \"entity_id\": [\"T8\"]}, \"Drug\": {\"text\": [[\"risperidone\"]], \"start\": [[109]], \"entity_id\": [\"T13\"]}}}" } ] } ]
19949685_2
Colonic necrosis is known as a rare complication following the administration of Kayexalate (sodium polystryrene sulfonate) in sorbitol.
true
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"following\"]], \"start\": [[49]], \"entity_id\": [\"T6\"]}, \"Effect\": {\"text\": [[\"Colonic necrosis\"]], \"start\": [[0]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"Kayexalate (sodium polystryrene sulfonate) in sorbitol\"]], \"start\": [[81]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"Kayexalate\"], [\"sorbitol\"]], \"start\": [[81], [127]], \"entity_id\": [\"T7\", \"T8\"]}, \"Combination\": [{\"event_id\": \"E2\", \"event_type\": \"Combination\", \"Trigger\": {\"text\": [[\"in\"]], \"start\": [[124]], \"entity_id\": [\"T9\"]}, \"Drug\": {\"text\": [[\"sorbitol\"], [\"Kayexalate\"]], \"start\": [[127], [81]], \"entity_id\": [\"T8\", \"T7\"]}}]}}" } ] } ]
12494253_3
Anaphylaxis to cisplatin is an infrequent life-threatening complication which may occur even in patients who have received prior treatment with cisplatin.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"occur\"]], \"start\": [[82]], \"entity_id\": [\"T6\"]}, \"Effect\": {\"text\": [[\"Anaphylaxis\"]], \"start\": [[0]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"cisplatin\"]], \"start\": [[15]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"cisplatin\"]], \"start\": [[15]], \"entity_id\": [\"T7\"]}}, \"Subject\": {\"text\": [[\"patients\"]], \"start\": [[96]], \"entity_id\": [\"T5\"]}, \"Severity\": {\"text\": [[\"life-threatening\"]], \"start\": [[42]], \"entity_id\": [\"T8\"], \"value\": \"High\"}}" } ] } ]
17324248_3
Piloerection induced by replacing fluvoxamine with milnacipran.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[13]], \"entity_id\": [\"T5\"]}, \"Effect\": {\"text\": [[\"Piloerection\"]], \"start\": [[0]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"replacing fluvoxamine with milnacipran\"]], \"start\": [[24]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"milnacipran\"], [\"fluvoxamine\"]], \"start\": [[51], [34]], \"entity_id\": [\"T7\", \"T8\"]}}}" } ] } ]
14601701_2
Ethambutol is an antimicrobial agent used frequently to treat tuberculosis.
false
[ { "events": [ { "event_id": "E1", "event_type": "Potential_therapeutic_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Potential_therapeutic_event\", \"Trigger\": {\"text\": [[\"treat\"]], \"start\": [[56]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"Ethambutol\"]], \"start\": [[0]], \"entity_id\": [\"T7\"], \"Disorder\": {\"text\": [[\"tuberculosis\"]], \"start\": [[62]], \"entity_id\": [\"T6\"]}, \"Drug\": {\"text\": [[\"Ethambutol\"]], \"start\": [[0]], \"entity_id\": [\"T9\"]}}, \"Speculated\": {\"text\": [[\"frequently\"]], \"start\": [[42]], \"entity_id\": [\"T8\"], \"value\": true}}" } ] } ]
15878975_4
The purpose of this review is to increase awareness among physicians and other health care professionals that DIC may be a rare but potentially severe complication of anti-D IGIV treatment.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"complication\"]], \"start\": [[151]], \"entity_id\": [\"T5\"]}, \"Effect\": {\"text\": [[\"DIC\"]], \"start\": [[110]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"anti-D IGIV\"]], \"start\": [[167]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"anti-D IGIV\"]], \"start\": [[167]], \"entity_id\": [\"T6\"]}}}" } ] } ]
8363533_2
Four Chinese female patients who suffered from manic-depressive disorder and underlying autoimmune thyroiditis developed transient episodes of thyrotoxicosis during maintenance lithium therapy.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"during\"]], \"start\": [[158]], \"entity_id\": [\"T6\"]}, \"Effect\": {\"text\": [[\"transient episodes of thyrotoxicosis\"]], \"start\": [[121]], \"entity_id\": [\"T3\"]}, \"Subject\": {\"text\": [[\"Four Chinese female patients who suffered from manic-depressive disorder and underlying autoimmune thyroiditis\"]], \"start\": [[0]], \"entity_id\": [\"T5\"], \"Population\": {\"text\": [[\"Four\"]], \"start\": [[0]], \"entity_id\": [\"T8\"]}, \"Race\": {\"text\": [[\"Chinese\"]], \"start\": [[5]], \"entity_id\": [\"T9\"]}, \"Gender\": {\"text\": [[\"female\"]], \"start\": [[13]], \"entity_id\": [\"T10\"]}, \"Disorder\": {\"text\": [[\"underlying autoimmune thyroiditis\"]], \"start\": [[77]], \"entity_id\": [\"T1\"]}}, \"Treatment\": {\"text\": [[\"maintenance lithium therapy\"]], \"start\": [[165]], \"entity_id\": [\"T7\"], \"Disorder\": {\"text\": [[\"manic-depressive disorder\"]], \"start\": [[47]], \"entity_id\": [\"T11\"]}, \"Drug\": {\"text\": [[\"lithium\"]], \"start\": [[177]], \"entity_id\": [\"T12\"]}}}" } ] } ]
17522786_2
Neurointensive care management of raised intracranial pressure caused by severe valproic acid intoxication.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"caused\"]], \"start\": [[63]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"raised intracranial pressure\"]], \"start\": [[34]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"valproic acid\"]], \"start\": [[80]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"valproic acid\"]], \"start\": [[80]], \"entity_id\": [\"T6\"]}}}" } ] } ]
15790469_1
Primary ovarian large B-cell lymphoma in patient with juvenile rheumatoid arthritis treated with low dose Methotrexate.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"in\"]], \"start\": [[38]], \"entity_id\": [\"T1\"]}, \"Subject\": {\"text\": [[\"patient with juvenile rheumatoid arthritis\"]], \"start\": [[41]], \"entity_id\": [\"T7\"]}, \"Treatment\": {\"text\": [[\"low dose Methotrexate\"]], \"start\": [[97]], \"entity_id\": [\"T9\"], \"Disorder\": {\"text\": [[\"juvenile rheumatoid arthritis\"]], \"start\": [[54]], \"entity_id\": [\"T11\"]}, \"Drug\": {\"text\": [[\"Methotrexate\"]], \"start\": [[106]], \"entity_id\": [\"T12\"]}, \"Dosage\": {\"text\": [[\"low dose\"]], \"start\": [[97]], \"entity_id\": [\"T2\"]}}, \"Effect\": {\"text\": [[\"Primary ovarian large B-cell lymphoma\"]], \"start\": [[0]], \"entity_id\": [\"T10\"]}}" } ] } ]
1420650_1
Asterixis induced by carbamazepine therapy.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[10]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"carbamazepine\"]], \"start\": [[21]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"carbamazepine\"]], \"start\": [[21]], \"entity_id\": [\"T6\"]}}, \"Effect\": {\"text\": [[\"Asterixis\"]], \"start\": [[0]], \"entity_id\": [\"T5\"]}}" } ] } ]
2320800_6
Ifosfamide is a known nephrotoxic drug with demonstrated tubulopathies.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"with\"]], \"start\": [[39]], \"entity_id\": [\"T5\"]}, \"Effect\": {\"text\": [[\"tubulopathies\"]], \"start\": [[57]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"Ifosfamide\"]], \"start\": [[0]], \"entity_id\": [\"T7\"], \"Drug\": {\"text\": [[\"Ifosfamide\"]], \"start\": [[0]], \"entity_id\": [\"T8\"]}}}" } ] } ]
7865488_1
A case of noncardiogenic pulmonary edema by ethanolamine oleate.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"by\"]], \"start\": [[41]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"ethanolamine oleate\"]], \"start\": [[44]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"ethanolamine oleate\"]], \"start\": [[44]], \"entity_id\": [\"T7\"]}}, \"Effect\": {\"text\": [[\"noncardiogenic pulmonary edema\"]], \"start\": [[10]], \"entity_id\": [\"T5\"]}, \"Subject\": {\"text\": [[\"A case\"]], \"start\": [[0]], \"entity_id\": [\"T6\"]}}" } ] } ]
11737689_1
A boy with chronic neutropenia and recurrent inflammatory skin lesions developed multiple erythematous nodules following administration of G-CSF.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[71]], \"entity_id\": [\"T4\"]}, \"Subject\": {\"text\": [[\"A boy with chronic neutropenia and recurrent inflammatory skin lesions\"]], \"start\": [[0]], \"entity_id\": [\"T3\"], \"Gender\": {\"text\": [[\"boy\"]], \"start\": [[2]], \"entity_id\": [\"T7\"]}}, \"Effect\": {\"text\": [[\"multiple erythematous nodules\"]], \"start\": [[81]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"G-CSF\"]], \"start\": [[139]], \"entity_id\": [\"T6\"], \"Disorder\": {\"text\": [[\"chronic neutropenia and recurrent inflammatory skin lesions\"]], \"start\": [[11]], \"entity_id\": [\"T9\"]}, \"Drug\": {\"text\": [[\"G-CSF\"]], \"start\": [[139]], \"entity_id\": [\"T10\"]}}}" } ] } ]
1261772_2
Fulminant hepatitis and lymphocyte sensitization due to propylthiouracil.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"due\"]], \"start\": [[49]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"propylthiouracil\"]], \"start\": [[56]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"propylthiouracil\"]], \"start\": [[56]], \"entity_id\": [\"T7\"]}}, \"Effect\": {\"text\": [[\"Fulminant hepatitis\"], [\"lymphocyte sensitization\"]], \"start\": [[0], [24]], \"entity_id\": [\"T4\", \"T5\"]}, \"Severity\": {\"text\": [[\"Fulminant\"]], \"start\": [[0]], \"entity_id\": [\"T8\"], \"value\": \"High\"}}" } ] } ]
9754850_5
We report on three patients with acute schizophrenia, who developed severe akathisia during treatment with olanzapine (20-25 mg/d).
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"with\"]], \"start\": [[102]], \"entity_id\": [\"T5\"]}, \"Subject\": {\"text\": [[\"three patients with acute schizophrenia\"]], \"start\": [[13]], \"entity_id\": [\"T3\"], \"Population\": {\"text\": [[\"three\"]], \"start\": [[13]], \"entity_id\": [\"T7\"]}}, \"Effect\": {\"text\": [[\"akathisia\"]], \"start\": [[75]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"olanzapine (20-25 mg/d)\"]], \"start\": [[107]], \"entity_id\": [\"T6\"], \"Disorder\": {\"text\": [[\"acute schizophrenia\"]], \"start\": [[33]], \"entity_id\": [\"T8\"]}, \"Drug\": {\"text\": [[\"olanzapine\"]], \"start\": [[107]], \"entity_id\": [\"T9\"]}, \"Dosage\": {\"text\": [[\"20-25 mg/d\"]], \"start\": [[119]], \"entity_id\": [\"T10\"]}}, \"Severity\": {\"text\": [[\"severe\"]], \"start\": [[68]], \"entity_id\": [\"T12\"], \"value\": \"High\"}}" } ] } ]
11206417_2
AIMS/HYPOTHESIS: There is evidence that insulin and glucose cause renal and ocular vasodilation.
true
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"cause\"]], \"start\": [[60]], \"entity_id\": [\"T10\"]}, \"Treatment\": {\"text\": [[\"insulin and glucose\"]], \"start\": [[40]], \"entity_id\": [\"T9\"], \"Drug\": {\"text\": [[\"glucose\"], [\"insulin\"]], \"start\": [[52], [40]], \"entity_id\": [\"T13\", \"T14\"]}, \"Combination\": [{\"event_id\": \"E2\", \"event_type\": \"Combination\", \"Trigger\": {\"text\": [[\"and\"]], \"start\": [[48]], \"entity_id\": [\"T12\"]}, \"Drug\": {\"text\": [[\"insulin\"], [\"glucose\"]], \"start\": [[40], [52]], \"entity_id\": [\"T14\", \"T13\"]}}]}, \"Effect\": {\"text\": [[\"renal and ocular vasodilation\"]], \"start\": [[66]], \"entity_id\": [\"T11\"]}}" } ] } ]
17536204_1
A cause-effect relationship to capecitabine was suggested due to resolution of headache with capecitabine withdrawal and reappearance with capecitabine rechallenge.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"relationship to\"]], \"start\": [[15]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"capecitabine\"]], \"start\": [[31]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"capecitabine\"]], \"start\": [[31]], \"entity_id\": [\"T6\"]}}, \"Effect\": {\"text\": [[\"headache\"]], \"start\": [[79]], \"entity_id\": [\"T3\"]}}" } ] } ]
7900744_6
This is a report of a case of anuric ARF after high-dose mannitol infusion for treatment of narrow-angle glaucoma that readily responded to acute hemodialysis.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"after\"]], \"start\": [[41]], \"entity_id\": [\"T7\"]}, \"Subject\": {\"text\": [[\"a case\"]], \"start\": [[20]], \"entity_id\": [\"T3\"]}, \"Effect\": {\"text\": [[\"anuric ARF\"]], \"start\": [[30]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"high-dose mannitol infusion\"]], \"start\": [[47]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"mannitol\"]], \"start\": [[57]], \"entity_id\": [\"T8\"]}, \"Route\": {\"text\": [[\"infusion\"]], \"start\": [[66]], \"entity_id\": [\"T9\"]}, \"Dosage\": {\"text\": [[\"high-dose\"]], \"start\": [[47]], \"entity_id\": [\"T10\"]}, \"Disorder\": {\"text\": [[\"narrow-angle glaucoma\"]], \"start\": [[92]], \"entity_id\": [\"T11\"]}}, \"Speculated\": {\"text\": [[\"readily\"]], \"start\": [[119]], \"entity_id\": [\"T12\"], \"value\": true}}" } ] } ]
23673446_6
She was treated with sorafenib at 400 mg daily.
false
[ { "events": [ { "event_id": "E1", "event_type": "Potential_therapeutic_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Potential_therapeutic_event\", \"Trigger\": {\"text\": [[\"treated\"]], \"start\": [[8]], \"entity_id\": [\"T5\"]}, \"Subject\": {\"text\": [[\"She\"]], \"start\": [[0]], \"entity_id\": [\"T4\"], \"Gender\": {\"text\": [[\"She\"]], \"start\": [[0]], \"entity_id\": [\"T7\"]}}, \"Treatment\": {\"text\": [[\"sorafenib at 400 mg daily\"]], \"start\": [[21]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"sorafenib\"]], \"start\": [[21]], \"entity_id\": [\"T8\"]}, \"Dosage\": {\"text\": [[\"400 mg\"]], \"start\": [[34]], \"entity_id\": [\"T9\"]}, \"Freq\": {\"text\": [[\"daily\"]], \"start\": [[41]], \"entity_id\": [\"T10\"]}}}" } ] } ]
18421192_2
The clinical course suggested that recombinant alpha-2b peginterferon plus ribavirin provoked type 1 diabetes mellitus, therefore, in patients who are candidates for interferon therapy the presence of pancreatic autoantibodies and the fasting plasma glucose level should be investigated before and during treatment.
true
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"provoked\"]], \"start\": [[85]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"recombinant alpha-2b peginterferon plus ribavirin\"]], \"start\": [[35]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"recombinant alpha-2b peginterferon\"], [\"ribavirin\"]], \"start\": [[35], [75]], \"entity_id\": [\"T7\", \"T9\"]}, \"Combination\": [{\"event_id\": \"E2\", \"event_type\": \"Combination\", \"Trigger\": {\"text\": [[\"plus\"]], \"start\": [[70]], \"entity_id\": [\"T8\"]}, \"Drug\": {\"text\": [[\"ribavirin\"], [\"recombinant alpha-2b peginterferon\"]], \"start\": [[75], [35]], \"entity_id\": [\"T9\", \"T7\"]}}]}, \"Effect\": {\"text\": [[\"type 1 diabetes mellitus\"]], \"start\": [[94]], \"entity_id\": [\"T6\"]}}" } ] } ]
19474653_1
Rhabdomyolysis following clarithromycin monotherapy.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"following\"]], \"start\": [[15]], \"entity_id\": [\"T3\"]}, \"Effect\": {\"text\": [[\"Rhabdomyolysis\"]], \"start\": [[0]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"clarithromycin monotherapy\"]], \"start\": [[25]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"clarithromycin\"]], \"start\": [[25]], \"entity_id\": [\"T6\"]}}}" } ] } ]
11788010_4
In addition to its known effect on gallbladder stasis, octreotide alters bile acid composition and may thus hasten intrahepatic sludge and stone formation.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"effect on\"]], \"start\": [[25]], \"entity_id\": [\"T11\"]}, \"Effect\": {\"text\": [[\"gallbladder stasis\", \"alters bile acid composition and may thus hasten intrahepatic sludge and stone formation\"]], \"start\": [[35, 66]], \"entity_id\": [\"T9\"]}, \"Treatment\": {\"text\": [[\"octreotide\"]], \"start\": [[55]], \"entity_id\": [\"T10\"], \"Drug\": {\"text\": [[\"octreotide\"]], \"start\": [[55]], \"entity_id\": [\"T12\"]}}}" } ] } ]
16326413_1
A 17-year-old boy with acute lymphoblastic leukemia developed acute renal failure within 48 h of an intravenous high-dose methotrexate (5 g/m2) infusion.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[52]], \"entity_id\": [\"T5\"]}, \"Subject\": {\"text\": [[\"17-year-old boy with acute lymphoblastic leukemia\"]], \"start\": [[2]], \"entity_id\": [\"T3\"], \"Age\": {\"text\": [[\"17-year-old\"]], \"start\": [[2]], \"entity_id\": [\"T8\"]}, \"Gender\": {\"text\": [[\"boy\"]], \"start\": [[14]], \"entity_id\": [\"T9\"]}}, \"Effect\": {\"text\": [[\"acute renal failure\"]], \"start\": [[62]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"intravenous high-dose methotrexate (5 g/m2) infusion\"]], \"start\": [[100]], \"entity_id\": [\"T7\"], \"Route\": {\"text\": [[\"intravenous\"]], \"start\": [[100]], \"entity_id\": [\"T10\"]}, \"Drug\": {\"text\": [[\"methotrexate\"]], \"start\": [[122]], \"entity_id\": [\"T11\"]}, \"Dosage\": {\"text\": [[\"5 g/m2\"]], \"start\": [[136]], \"entity_id\": [\"T12\"]}, \"Time_elapsed\": {\"text\": [[\"within 48 h\"]], \"start\": [[82]], \"entity_id\": [\"T13\"]}, \"Disorder\": {\"text\": [[\"acute lymphoblastic leukemia\"]], \"start\": [[23]], \"entity_id\": [\"T14\"]}}}" } ] } ]
2116935_1
Splenic hemorrhage: a complication of tissue plasminogen activator treatment.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"complication of\"]], \"start\": [[22]], \"entity_id\": [\"T5\"]}, \"Effect\": {\"text\": [[\"Splenic hemorrhage\"]], \"start\": [[0]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"tissue plasminogen activator treatment\"]], \"start\": [[38]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"tissue plasminogen activator\"]], \"start\": [[38]], \"entity_id\": [\"T7\"]}}}" } ] } ]
18648015_2
CONCLUSIONS: Cefazolin was a probable cause of this patient's leukopenia.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"cause\"]], \"start\": [[38]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"Cefazolin\"]], \"start\": [[13]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"Cefazolin\"]], \"start\": [[13]], \"entity_id\": [\"T8\"]}}, \"Subject\": {\"text\": [[\"patient\"]], \"start\": [[52]], \"entity_id\": [\"T6\"]}, \"Effect\": {\"text\": [[\"leukopenia\"]], \"start\": [[62]], \"entity_id\": [\"T7\"]}, \"Speculated\": {\"text\": [[\"probable\"]], \"start\": [[29]], \"entity_id\": [\"T4\"], \"value\": true}}" } ] } ]
15533031_1
Paradoxical cerebral cortical hyperexcitability following flupirtine overdose.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"following\"]], \"start\": [[48]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"Paradoxical cerebral cortical hyperexcitability\"]], \"start\": [[0]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"flupirtine overdose\"]], \"start\": [[58]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"flupirtine\"]], \"start\": [[58]], \"entity_id\": [\"T6\"]}, \"Dosage\": {\"text\": [[\"overdose\"]], \"start\": [[69]], \"entity_id\": [\"T7\"]}}}" } ] } ]
6245286_1
Autopsy evidence of herpesvirus infection was found in visceral organs of four leukemic patients who had received large doses of cytarabine (cytosine arabinoside; Ara-C) shortly before their death.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"found\"]], \"start\": [[46]], \"entity_id\": [\"T8\"]}, \"Effect\": {\"text\": [[\"herpesvirus infection\"]], \"start\": [[20]], \"entity_id\": [\"T5\"]}, \"Subject\": {\"text\": [[\"four leukemic patients\"]], \"start\": [[74]], \"entity_id\": [\"T6\"], \"Population\": {\"text\": [[\"four\"]], \"start\": [[74]], \"entity_id\": [\"T10\"]}}, \"Treatment\": {\"text\": [[\"large doses of cytarabine\"]], \"start\": [[114]], \"entity_id\": [\"T7\"], \"Drug\": {\"text\": [[\"cytarabine (cytosine arabinoside; Ara-C)\"]], \"start\": [[129]], \"entity_id\": [\"T11\"]}, \"Disorder\": {\"text\": [[\"leukemic\"]], \"start\": [[79]], \"entity_id\": [\"T12\"]}}}" } ] } ]
4004433_1
Heparin-induced hyperkalemia.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[8]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"Heparin\"]], \"start\": [[0]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"Heparin\"]], \"start\": [[0]], \"entity_id\": [\"T6\"]}}, \"Effect\": {\"text\": [[\"hyperkalemia\"]], \"start\": [[16]], \"entity_id\": [\"T5\"]}}" } ] } ]
6608139_1
Although myelosuppression is mild, immunosuppression and superinfection are potential hazards of treatment with DCF.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"hazards\"]], \"start\": [[86]], \"entity_id\": [\"T7\"]}, \"Treatment\": {\"text\": [[\"DCF\"]], \"start\": [[112]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"DCF\"]], \"start\": [[112]], \"entity_id\": [\"T8\"]}}, \"Effect\": {\"text\": [[\"myelosuppression\", \"immunosuppression and superinfection\"]], \"start\": [[9, 35]], \"entity_id\": [\"T6\"]}, \"Severity\": {\"text\": [[\"mild\"]], \"start\": [[29]], \"entity_id\": [\"T9\"], \"value\": \"Low\"}, \"Speculated\": {\"text\": [[\"potential\"]], \"start\": [[76]], \"entity_id\": [\"T10\"], \"value\": true}}" } ] } ]
2076372_2
The photosensitivity is still present 3 years after the withdrawal of quinine.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"after\"]], \"start\": [[46]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"withdrawal of quinine\"]], \"start\": [[56]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"quinine\"]], \"start\": [[70]], \"entity_id\": [\"T6\"]}}, \"Effect\": {\"text\": [[\"photosensitivity is still present 3 years\"]], \"start\": [[4]], \"entity_id\": [\"T5\"]}}" } ] } ]
8396491_1
Interference with the cortisol axis by the microtubule antagonist, CPH82.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"by\"]], \"start\": [[36]], \"entity_id\": [\"T3\"]}, \"Effect\": {\"text\": [[\"Interference with the cortisol axis\"]], \"start\": [[0]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"CPH82\"]], \"start\": [[67]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"CPH82\"]], \"start\": [[67]], \"entity_id\": [\"T6\"]}}}" } ] } ]
9892272_2
Physicians should be aware of the possible association between the use of alteplase and the development of subfascial hemorrhage.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"development\"]], \"start\": [[92]], \"entity_id\": [\"T3\"]}, \"Effect\": {\"text\": [[\"subfascial hemorrhage\"]], \"start\": [[107]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"alteplase\"]], \"start\": [[74]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"alteplase\"]], \"start\": [[74]], \"entity_id\": [\"T8\"]}}, \"Speculated\": {\"text\": [[\"possible\"]], \"start\": [[34]], \"entity_id\": [\"T6\"], \"value\": true}}" } ] } ]
3763264_5
The clinical findings and laboratory studies suggested an autoimmune cell-mediated hypersensitivity reaction triggered by phenobarbital.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"triggered\"]], \"start\": [[109]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"phenobarbital\"]], \"start\": [[122]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"phenobarbital\"]], \"start\": [[122]], \"entity_id\": [\"T7\"]}}, \"Effect\": {\"text\": [[\"an autoimmune cell-mediated hypersensitivity reaction\"]], \"start\": [[55]], \"entity_id\": [\"T6\"]}}" } ] } ]
9642842_1
Anaphylactic reaction to oral prednisone: a case report and review of the literature.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"to\"]], \"start\": [[22]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"Anaphylactic reaction\"]], \"start\": [[0]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"oral prednisone\"]], \"start\": [[25]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"prednisone\"]], \"start\": [[30]], \"entity_id\": [\"T6\"]}, \"Route\": {\"text\": [[\"oral\"]], \"start\": [[25]], \"entity_id\": [\"T7\"]}}, \"Subject\": {\"text\": [[\"a case\"]], \"start\": [[42]], \"entity_id\": [\"T8\"]}}" } ] } ]
9634122_2
Prolonged prostate-specific antigen response in flutamide withdrawal syndrome despite disease progression.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"in\"]], \"start\": [[45]], \"entity_id\": [\"T7\"]}, \"Treatment\": {\"text\": [[\"flutamide\"]], \"start\": [[48]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"flutamide\"]], \"start\": [[48]], \"entity_id\": [\"T8\"]}}, \"Effect\": {\"text\": [[\"Prolonged prostate-specific antigen response\"]], \"start\": [[0]], \"entity_id\": [\"T6\"]}}" } ] } ]
7436161_4
None of them had a history of cardiac disease, and with the possible exception of one case of cardiac arrest, where the patient received doxorubicin, no predisposing factors could be found.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"received\"]], \"start\": [[128]], \"entity_id\": [\"T8\"]}, \"Effect\": {\"text\": [[\"cardiac arrest\"]], \"start\": [[94]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"doxorubicin\"]], \"start\": [[137]], \"entity_id\": [\"T7\"], \"Drug\": {\"text\": [[\"doxorubicin\"]], \"start\": [[137]], \"entity_id\": [\"T9\"]}}, \"Subject\": {\"text\": [[\"the patient\"]], \"start\": [[116]], \"entity_id\": [\"T5\"]}}" } ] } ]
8013261_4
We report a case of IDDM which occurred during interferon therapy for chronic hepatitis.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"occurred\"]], \"start\": [[31]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"IDDM\"]], \"start\": [[20]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"interferon therapy\"]], \"start\": [[47]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"interferon\"]], \"start\": [[47]], \"entity_id\": [\"T7\"]}, \"Disorder\": {\"text\": [[\"chronic hepatitis.\"]], \"start\": [[70]], \"entity_id\": [\"T8\"]}}, \"Subject\": {\"text\": [[\"a case\"]], \"start\": [[10]], \"entity_id\": [\"T9\"]}}" } ] } ]
11174414_4
Though physicians treating large populations of patients with HIV are well aware of this complication, only one other report of nevirapine-associated SJS has been documented in the dermatology literature.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"associated\"]], \"start\": [[139]], \"entity_id\": [\"T9\"]}, \"Treatment\": {\"text\": [[\"nevirapine\"]], \"start\": [[128]], \"entity_id\": [\"T8\"], \"Drug\": {\"text\": [[\"nevirapine\"]], \"start\": [[128]], \"entity_id\": [\"T13\"]}, \"Disorder\": {\"text\": [[\"HIV\"]], \"start\": [[62]], \"entity_id\": [\"T14\"]}}, \"Effect\": {\"text\": [[\"SJS\"]], \"start\": [[150]], \"entity_id\": [\"T10\"]}, \"Subject\": {\"text\": [[\"patients with HIV\"]], \"start\": [[48]], \"entity_id\": [\"T11\"]}}" } ] } ]
16119501_4
We report a case of baclofen withdrawal syndrome resulting from oral baclofen underdosing.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"resulting\"]], \"start\": [[49]], \"entity_id\": [\"T5\"]}, \"Effect\": {\"text\": [[\"baclofen withdrawal syndrome\"]], \"start\": [[20]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"oral baclofen underdosing\"]], \"start\": [[64]], \"entity_id\": [\"T6\"], \"Route\": {\"text\": [[\"oral\"]], \"start\": [[64]], \"entity_id\": [\"T7\"]}, \"Drug\": {\"text\": [[\"baclofen\"]], \"start\": [[69]], \"entity_id\": [\"T8\"]}, \"Dosage\": {\"text\": [[\"underdosing\"]], \"start\": [[78]], \"entity_id\": [\"T9\"]}}}" } ] } ]
9403220_1
A 35-year-old nephrotic man developed acute renal failure with serum creatinine to 1543 micromol/l after a month of therapy with enalapril.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"after\"]], \"start\": [[99]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"a month of therapy with enalapril\"]], \"start\": [[105]], \"entity_id\": [\"T4\"], \"Disorder\": {\"text\": [[\"nephrotic\"]], \"start\": [[14]], \"entity_id\": [\"T8\"]}, \"Duration\": {\"text\": [[\"a month\"]], \"start\": [[105]], \"entity_id\": [\"T10\"]}, \"Drug\": {\"text\": [[\"enalapril\"]], \"start\": [[129]], \"entity_id\": [\"T11\"]}}, \"Effect\": {\"text\": [[\"acute renal failure with serum creatinine to 1543 micromol/l\"]], \"start\": [[38]], \"entity_id\": [\"T5\"]}, \"Subject\": {\"text\": [[\"A 35-year-old nephrotic man\"]], \"start\": [[0]], \"entity_id\": [\"T6\"], \"Age\": {\"text\": [[\"35-year-old\"]], \"start\": [[2]], \"entity_id\": [\"T7\"]}, \"Gender\": {\"text\": [[\"man\"]], \"start\": [[24]], \"entity_id\": [\"T9\"]}}, \"Severity\": {\"text\": [[\"acute\"]], \"start\": [[38]], \"entity_id\": [\"T12\"], \"value\": \"High\"}}" } ] } ]
7663030_14
Comparable adverse effects, such as disorientation and temporary amnesia, have been reported in patients in the analogous agent, propranolol.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"been reported\"]], \"start\": [[79]], \"entity_id\": [\"T7\"]}, \"Treatment\": {\"text\": [[\"propranolol\"]], \"start\": [[129]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"propranolol\"]], \"start\": [[129]], \"entity_id\": [\"T9\"]}}, \"Effect\": {\"text\": [[\"disorientation and temporary amnesia\"]], \"start\": [[36]], \"entity_id\": [\"T6\"]}, \"Subject\": {\"text\": [[\"patients\"]], \"start\": [[96]], \"entity_id\": [\"T8\"]}}" } ] } ]
18821094_2
This is an image and brief case report of a 13-year-old boy who presented with severe rash and systemic symptoms after starting oxcarbazepine.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"after\"]], \"start\": [[113]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"oxcarbazepine\"]], \"start\": [[128]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"oxcarbazepine\"]], \"start\": [[128]], \"entity_id\": [\"T10\"]}}, \"Effect\": {\"text\": [[\"severe rash and systemic symptoms\"]], \"start\": [[79]], \"entity_id\": [\"T5\"]}, \"Subject\": {\"text\": [[\"a 13-year-old boy\"]], \"start\": [[42]], \"entity_id\": [\"T6\"], \"Age\": {\"text\": [[\"13-year-old\"]], \"start\": [[44]], \"entity_id\": [\"T7\"]}, \"Gender\": {\"text\": [[\"boy\"]], \"start\": [[56]], \"entity_id\": [\"T8\"]}}, \"Severity\": {\"text\": [[\"severe\"]], \"start\": [[79]], \"entity_id\": [\"T9\"], \"value\": \"Medium\"}}" } ] } ]
489527_1
Renal damage associated with long term use of lithium carbonate.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"associated\"]], \"start\": [[13]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"Renal damage\"]], \"start\": [[0]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"lithium carbonate\"]], \"start\": [[46]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"lithium carbonate.\"]], \"start\": [[46]], \"entity_id\": [\"T6\"]}}}" } ] } ]
20456080_1
Triamcinolone acetonide induced secondary adrenal insufficiency related to impaired CYP3A4 metabolism by coadministration of nefazodone.
true
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[24]], \"entity_id\": [\"T7\"]}, \"Treatment\": {\"text\": [[\"Triamcinolone acetonide\", \"coadministration of nefazodone\"]], \"start\": [[0, 105]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"Triamcinolone acetonide\"], [\"nefazodone\"]], \"start\": [[0], [125]], \"entity_id\": [\"T9\", \"T10\"]}, \"Combination\": [{\"event_id\": \"E2\", \"event_type\": \"Combination\", \"Trigger\": {\"text\": [[\"coadministration\"]], \"start\": [[105]], \"entity_id\": [\"T11\"]}, \"Drug\": {\"text\": [[\"nefazodone\"], [\"Triamcinolone acetonide\"]], \"start\": [[125], [0]], \"entity_id\": [\"T10\", \"T9\"]}}]}, \"Effect\": {\"text\": [[\"secondary adrenal insufficiency\"]], \"start\": [[32]], \"entity_id\": [\"T8\"]}}" } ] } ]
16044093_1
Hepatocellular damage following therapeutic intravenous iron sucrose infusion in a child.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"following\"]], \"start\": [[22]], \"entity_id\": [\"T5\"]}, \"Subject\": {\"text\": [[\"a child\"]], \"start\": [[81]], \"entity_id\": [\"T3\"], \"Age\": {\"text\": [[\"child\"]], \"start\": [[83]], \"entity_id\": [\"T7\"]}}, \"Effect\": {\"text\": [[\"Hepatocellular damage\"]], \"start\": [[0]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"intravenous iron sucrose infusion\"]], \"start\": [[44]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"iron sucrose\"]], \"start\": [[56]], \"entity_id\": [\"T8\"]}, \"Route\": {\"text\": [[\"intravenous\", \"infusion\"]], \"start\": [[44, 69]], \"entity_id\": [\"T9\"]}}}" } ] } ]
14641354_2
We report a 43-year-old woman who developed sore throat, swelling of the lips and oral cavity and dysphagia, 2 weeks after the use of budesonide spray (Budefat) for treatment of bronchial asthma.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[34]], \"entity_id\": [\"T11\"]}, \"Subject\": {\"text\": [[\"a 43-year-old woman\"]], \"start\": [[10]], \"entity_id\": [\"T10\"], \"Age\": {\"text\": [[\"43-year-old\"]], \"start\": [[12]], \"entity_id\": [\"T15\"]}, \"Gender\": {\"text\": [[\"woman\"]], \"start\": [[24]], \"entity_id\": [\"T16\"]}}, \"Effect\": {\"text\": [[\"sore throat, swelling of the lips and oral cavity and dysphagia\"]], \"start\": [[44]], \"entity_id\": [\"T12\"]}, \"Treatment\": {\"text\": [[\"2 weeks after the use of budesonide spray (Budefat)\"]], \"start\": [[109]], \"entity_id\": [\"T13\"], \"Time_elapsed\": {\"text\": [[\"2 weeks after\"]], \"start\": [[109]], \"entity_id\": [\"T17\"]}, \"Drug\": {\"text\": [[\"budesonide\"], [\"Budefat\"]], \"start\": [[134], [152]], \"entity_id\": [\"T18\", \"T19\"]}, \"Disorder\": {\"text\": [[\"bronchial asthma.\"]], \"start\": [[178]], \"entity_id\": [\"T20\"]}, \"Route\": {\"text\": [[\"spray\"]], \"start\": [[145]], \"entity_id\": [\"T21\"]}}}" } ] } ]
7496198_9
Among the risk factors studied, two appear to increase the risk of ARE: the prescription of thiabendazole to treat strongyloidiasis during the melarsoprol cure and the bad general clinical conditions of patients.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"appear to\"]], \"start\": [[36]], \"entity_id\": [\"T12\"]}, \"Treatment\": {\"text\": [[\"prescription of thiabendazole\", \"during the melarsoprol cure\"]], \"start\": [[76, 132]], \"entity_id\": [\"T9\"], \"Drug\": {\"text\": [[\"thiabendazole\"], [\"melarsoprol\"]], \"start\": [[92], [143]], \"entity_id\": [\"T13\", \"T15\"]}, \"Disorder\": {\"text\": [[\"strongyloidiasis\"]], \"start\": [[115]], \"entity_id\": [\"T14\"]}}, \"Effect\": {\"text\": [[\"increase the risk of ARE\"]], \"start\": [[46]], \"entity_id\": [\"T10\"]}, \"Speculated\": {\"text\": [[\"appear to\"]], \"start\": [[36]], \"entity_id\": [\"T16\"], \"value\": true}}" } ] } ]
3997294_2
Review of this and previously reported cases indicates the need for early diagnosis of amiodarone pneumonitis, immediate withdrawal of amiodarone, and prompt but continued steroid therapy to ensure full recovery.
true
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"of\"]], \"start\": [[84]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"amiodarone\"]], \"start\": [[87]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"amiodarone\"]], \"start\": [[87]], \"entity_id\": [\"T6\"]}}, \"Effect\": {\"text\": [[\"pneumonitis\"]], \"start\": [[98]], \"entity_id\": [\"T4\"]}}" }, { "event_id": "E2", "event_type": "Potential_therapeutic_event", "event_data": "{\"event_id\": \"E2\", \"event_type\": \"Potential_therapeutic_event\", \"Trigger\": {\"text\": [[\"recovery\"]], \"start\": [[203]], \"entity_id\": [\"T12\"]}, \"Treatment\": {\"text\": [[\"immediate withdrawal of amiodarone, and prompt but continued steroid therapy\"]], \"start\": [[111]], \"entity_id\": [\"T9\"], \"Disorder\": {\"text\": [[\"pneumonitis\"]], \"start\": [[98]], \"entity_id\": [\"T8\"]}, \"Drug\": {\"text\": [[\"steroid\"], [\"amiodarone\"]], \"start\": [[172], [135]], \"entity_id\": [\"T10\", \"T11\"]}}}" } ] } ]
12503933_2
A second possibility is an interaction between clarithromycin and isradipine, potentially increasing the hepatic toxicity of isradipine.
true
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"increasing\"]], \"start\": [[90]], \"entity_id\": [\"T6\"]}, \"Effect\": {\"text\": [[\"hepatic toxicity\"]], \"start\": [[105]], \"entity_id\": [\"T7\"]}, \"Treatment\": {\"text\": [[\"interaction between clarithromycin and isradipine\"]], \"start\": [[27]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"clarithromycin\"], [\"isradipine\"]], \"start\": [[47], [66]], \"entity_id\": [\"T10\", \"T11\"]}, \"Combination\": [{\"event_id\": \"E2\", \"event_type\": \"Combination\", \"Trigger\": {\"text\": [[\"interaction\"]], \"start\": [[27]], \"entity_id\": [\"T9\"]}, \"Drug\": {\"text\": [[\"clarithromycin\"], [\"isradipine\"]], \"start\": [[47], [66]], \"entity_id\": [\"T10\", \"T11\"]}}]}, \"Speculated\": {\"text\": [[\"potentially\"]], \"start\": [[78]], \"entity_id\": [\"T8\"], \"value\": true}}" } ] } ]
1584367_3
We report two cases of cerebrospinal fluid eosinophilia (CSFE) secondary to the intraventricular administration of vancomycin.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"secondary\"]], \"start\": [[63]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"intraventricular administration of vancomycin\"]], \"start\": [[80]], \"entity_id\": [\"T6\"], \"Route\": {\"text\": [[\"intraventricular\"]], \"start\": [[80]], \"entity_id\": [\"T10\"]}, \"Drug\": {\"text\": [[\"vancomycin\"]], \"start\": [[115]], \"entity_id\": [\"T11\"]}}, \"Effect\": {\"text\": [[\"cerebrospinal fluid eosinophilia (CSFE)\"]], \"start\": [[23]], \"entity_id\": [\"T9\"]}, \"Subject\": {\"text\": [[\"two cases\"]], \"start\": [[10]], \"entity_id\": [\"T1\"], \"Population\": {\"text\": [[\"two\"]], \"start\": [[10]], \"entity_id\": [\"T8\"]}}}" } ] } ]
19857154_4
We describe two patients who experienced serious quetiapine adverse effects potentially mediated through an interaction with ritonavir-boosted atazanavir.
true
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"experienced\"]], \"start\": [[29]], \"entity_id\": [\"T10\"]}, \"Subject\": {\"text\": [[\"two patients\"]], \"start\": [[12]], \"entity_id\": [\"T8\"], \"Population\": {\"text\": [[\"two\"]], \"start\": [[12]], \"entity_id\": [\"T13\"]}}, \"Effect\": {\"text\": [[\"serious quetiapine adverse effects\"]], \"start\": [[41]], \"entity_id\": [\"T11\"]}, \"Treatment\": {\"text\": [[\"ritonavir-boosted atazanavir\"]], \"start\": [[125]], \"entity_id\": [\"T12\"], \"Drug\": {\"text\": [[\"ritonavir\"], [\"atazanavir\"]], \"start\": [[125], [143]], \"entity_id\": [\"T14\", \"T16\"]}, \"Combination\": [{\"event_id\": \"E2\", \"event_type\": \"Combination\", \"Trigger\": {\"text\": [[\"interaction\"]], \"start\": [[108]], \"entity_id\": [\"T15\"]}, \"Drug\": {\"text\": [[\"ritonavir\"], [\"atazanavir\"]], \"start\": [[125], [143]], \"entity_id\": [\"T14\", \"T16\"]}}]}, \"Speculated\": {\"text\": [[\"potentially\"]], \"start\": [[76]], \"entity_id\": [\"T9\"], \"value\": true}}" } ] } ]
11020127_4
The patient was diagnosed with carbamazepine toxicity related to the introduction of ritonavir.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"related\"]], \"start\": [[54]], \"entity_id\": [\"T7\"]}, \"Treatment\": {\"text\": [[\"ritonavir\"]], \"start\": [[85]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"ritonavir\"]], \"start\": [[85]], \"entity_id\": [\"T8\"]}}, \"Subject\": {\"text\": [[\"patient\"]], \"start\": [[4]], \"entity_id\": [\"T5\"]}, \"Effect\": {\"text\": [[\"carbamazepine toxicity\"]], \"start\": [[31]], \"entity_id\": [\"T6\"]}}" } ] } ]
17987285_12
Caution should be exercised, especially in patients who are given voriconazole or fluconazole during long-lasting fentanyl treatment, because insidiously elevated fentanyl concentration may lead to respiratory depression.
true
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"lead\"]], \"start\": [[190]], \"entity_id\": [\"T10\"]}, \"Subject\": {\"text\": [[\"patients\"]], \"start\": [[43]], \"entity_id\": [\"T8\"]}, \"Treatment\": {\"text\": [[\"fentanyl\"]], \"start\": [[114]], \"entity_id\": [\"T9\"], \"Drug\": {\"text\": [[\"voriconazole\"], [\"fluconazole\"], [\"fentanyl\"]], \"start\": [[66], [82], [163]], \"entity_id\": [\"T12\", \"T13\", \"T15\"]}, \"Combination\": [{\"event_id\": \"E2\", \"event_type\": \"Combination\", \"Trigger\": {\"text\": [[\"during\"]], \"start\": [[94]], \"entity_id\": [\"T14\"]}, \"Drug\": {\"text\": [[\"voriconazole\"], [\"fluconazole\"]], \"start\": [[66], [82]], \"entity_id\": [\"T12\", \"T13\"]}}]}, \"Effect\": {\"text\": [[\"respiratory depression\"]], \"start\": [[198]], \"entity_id\": [\"T11\"]}}" } ] } ]
15878975_5
This review presents the first case series of DIC associated with acute hemoglobinemia or hemoglobinuria following anti-D IGIV administration for ITP.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"following\"]], \"start\": [[105]], \"entity_id\": [\"T9\"]}, \"Effect\": {\"text\": [[\"DIC associated with acute hemoglobinemia or hemoglobinuria\"]], \"start\": [[46]], \"entity_id\": [\"T8\"]}, \"Treatment\": {\"text\": [[\"anti-D IGIV administration\"]], \"start\": [[115]], \"entity_id\": [\"T10\"], \"Route\": {\"text\": [[\"IV administration\"]], \"start\": [[124]], \"entity_id\": [\"T7\"]}, \"Drug\": {\"text\": [[\"anti-D\"]], \"start\": [[115]], \"entity_id\": [\"T12\"]}, \"Disorder\": {\"text\": [[\"ITP\"]], \"start\": [[146]], \"entity_id\": [\"T13\"]}}}" } ] } ]
15795553_1
Risperidone is a frequently used member of a new class of atypical antipsychotics-the serotonin-dopamine antagonists (SDAs)-due to its comparatively high efficacy and low D2/5HT2 binding ratio, which results in a low incidence of extrapyramidal side effects including tardive dyskinesia (TD).
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"results\"]], \"start\": [[200]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"Risperidone\"]], \"start\": [[0]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"Risperidone\"]], \"start\": [[0]], \"entity_id\": [\"T9\"]}}, \"Effect\": {\"text\": [[\"tardive dyskinesia\"]], \"start\": [[268]], \"entity_id\": [\"T8\"]}}" } ] } ]
10458196_1
A 5-month-old infant became lethargic and poorly responsive after receiving 1 drop of brimonidine in each eye.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"became\"]], \"start\": [[21]], \"entity_id\": [\"T8\"]}, \"Subject\": {\"text\": [[\"A 5-month-old infant\"]], \"start\": [[0]], \"entity_id\": [\"T5\"], \"Age\": {\"text\": [[\"5-month-old\"], [\"infant\"]], \"start\": [[2], [14]], \"entity_id\": [\"T11\", \"T12\"]}}, \"Effect\": {\"text\": [[\"lethargic and poorly responsive\"]], \"start\": [[28]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"receiving 1 drop of brimonidine in each eye\"]], \"start\": [[66]], \"entity_id\": [\"T7\"], \"Drug\": {\"text\": [[\"brimonidine\"]], \"start\": [[86]], \"entity_id\": [\"T9\"]}, \"Dosage\": {\"text\": [[\"1 drop\"]], \"start\": [[76]], \"entity_id\": [\"T10\"]}, \"Route\": {\"text\": [[\"in each eye\"]], \"start\": [[98]], \"entity_id\": [\"T13\"]}}}" } ] } ]
489527_2
The authors report 2 cases of renal damage associated with lithium carbonate treatment.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"associated\"]], \"start\": [[43]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"renal damage\"]], \"start\": [[30]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"lithium carbonate treatment\"]], \"start\": [[59]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"lithium carbonate\"]], \"start\": [[59]], \"entity_id\": [\"T8\"]}}, \"Subject\": {\"text\": [[\"2 cases\"]], \"start\": [[19]], \"entity_id\": [\"T6\"], \"Population\": {\"text\": [[\"2\"]], \"start\": [[19]], \"entity_id\": [\"T7\"]}}}" } ] } ]
9545161_4
It was hypothesized that valproic acid may interfere with glucuronidation of lamotrigine, leading to increased serum lamotrigine levels, or perhaps alter the drug's metabolism, resulting in accumulation of a toxic intermediate metabolite.
true
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"leading\"]], \"start\": [[90]], \"entity_id\": [\"T10\"]}, \"Treatment\": {\"text\": [[\"valproic acid may interfere with glucuronidation of lamotrigine\"]], \"start\": [[25]], \"entity_id\": [\"T8\"], \"Drug\": {\"text\": [[\"valproic acid\"], [\"lamotrigine\"]], \"start\": [[25], [77]], \"entity_id\": [\"T12\", \"T13\"]}, \"Combination\": [{\"event_id\": \"E2\", \"event_type\": \"Combination\", \"Trigger\": {\"text\": [[\"interfere\"]], \"start\": [[43]], \"entity_id\": [\"T11\"]}, \"Drug\": {\"text\": [[\"valproic acid\"], [\"lamotrigine\"]], \"start\": [[25], [77]], \"entity_id\": [\"T12\", \"T13\"]}}]}, \"Effect\": {\"text\": [[\"increased serum lamotrigine levels, or perhaps alter the drug's metabolism, resulting in accumulation of a toxic intermediate metabolite\"]], \"start\": [[101]], \"entity_id\": [\"T9\"]}, \"Speculated\": {\"text\": [[\"hypothesized\"]], \"start\": [[7]], \"entity_id\": [\"T7\"], \"value\": true}}" } ] } ]
10650865_1
Portal vein thrombosis in a patient with severe haemophilia A and F V G1691A mutation during continuous infusion of F VIII after intramural jejunal bleeding--successful thrombolysis under heparin therapy.
true
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"during\"]], \"start\": [[86]], \"entity_id\": [\"T7\"]}, \"Treatment\": {\"text\": [[\"continuous infusion of F VIII\"]], \"start\": [[93]], \"entity_id\": [\"T5\"], \"Disorder\": {\"text\": [[\"intramural jejunal bleeding\"]], \"start\": [[129]], \"entity_id\": [\"T11\"]}, \"Route\": {\"text\": [[\"continuous infusion\"]], \"start\": [[93]], \"entity_id\": [\"T9\"]}, \"Drug\": {\"text\": [[\"F VIII\"]], \"start\": [[116]], \"entity_id\": [\"T10\"]}}, \"Subject\": {\"text\": [[\"a patient with severe haemophilia A and F V G1691A mutation\"]], \"start\": [[26]], \"entity_id\": [\"T4\"], \"Disorder\": {\"text\": [[\"haemophilia A and F V G1691A mutation\"]], \"start\": [[48]], \"entity_id\": [\"T8\"]}}, \"Effect\": {\"text\": [[\"Portal vein thrombosis\"]], \"start\": [[0]], \"entity_id\": [\"T3\"]}}" }, { "event_id": "E2", "event_type": "Potential_therapeutic_event", "event_data": "{\"event_id\": \"E2\", \"event_type\": \"Potential_therapeutic_event\", \"Trigger\": {\"text\": [[\"therapy\"]], \"start\": [[196]], \"entity_id\": [\"T1\"]}, \"Treatment\": {\"text\": [[\"heparin\"]], \"start\": [[188]], \"entity_id\": [\"T2\"], \"Disorder\": {\"text\": [[\"Portal vein thrombosis\"]], \"start\": [[0]], \"entity_id\": [\"T12\"]}, \"Drug\": {\"text\": [[\"heparin\"]], \"start\": [[188]], \"entity_id\": [\"T6\"]}}, \"Effect\": {\"text\": [[\"successful thrombolysis\"]], \"start\": [[158]], \"entity_id\": [\"T13\"]}}" } ] } ]
6093724_1
A healthy, 30-year-old man, exposed to sulindac on two separate occasions, had an incapacitating isolated idential sensory neuropathy.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"exposed\"]], \"start\": [[28]], \"entity_id\": [\"T6\"]}, \"Effect\": {\"text\": [[\"incapacitating isolated idential sensory neuropathy\"]], \"start\": [[82]], \"entity_id\": [\"T3\"]}, \"Subject\": {\"text\": [[\"A healthy, 30-year-old man\"]], \"start\": [[0]], \"entity_id\": [\"T4\"], \"Age\": {\"text\": [[\"30-year-old\"]], \"start\": [[11]], \"entity_id\": [\"T7\"]}, \"Gender\": {\"text\": [[\"man\"]], \"start\": [[23]], \"entity_id\": [\"T8\"]}}, \"Treatment\": {\"text\": [[\"sulindac\"]], \"start\": [[39]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"sulindac\"]], \"start\": [[39]], \"entity_id\": [\"T9\"]}}}" } ] } ]
7439122_1
Clofibrate-induced myopathy in patients with diabetes insipidus.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[11]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"Clofibrate\"]], \"start\": [[0]], \"entity_id\": [\"T3\"], \"Disorder\": {\"text\": [[\"diabetes insipidus\"]], \"start\": [[45]], \"entity_id\": [\"T7\"]}, \"Drug\": {\"text\": [[\"Clofibrate\"]], \"start\": [[0]], \"entity_id\": [\"T8\"]}}, \"Effect\": {\"text\": [[\"myopathy\"]], \"start\": [[19]], \"entity_id\": [\"T5\"]}, \"Subject\": {\"text\": [[\"patients with diabetes insipidus\"]], \"start\": [[31]], \"entity_id\": [\"T6\"]}}" } ] } ]
17473493_2
This is the first histologically confirmed case of NASH that was aggravated by raloxifene.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"aggravated\"]], \"start\": [[65]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"NASH\"]], \"start\": [[51]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"raloxifene\"]], \"start\": [[79]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"raloxifene\"]], \"start\": [[79]], \"entity_id\": [\"T6\"]}}, \"Subject\": {\"text\": [[\"the first histologically confirmed case\"]], \"start\": [[8]], \"entity_id\": [\"T7\"]}}" } ] } ]
9545161_5
To date, eight cases of TEN and one of SJS related to lamotrigine administration have been reported in the literature.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"related\"]], \"start\": [[43]], \"entity_id\": [\"T7\"]}, \"Treatment\": {\"text\": [[\"lamotrigine\"]], \"start\": [[54]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"lamotrigine\"]], \"start\": [[54]], \"entity_id\": [\"T8\"]}}, \"Effect\": {\"text\": [[\"TEN\", \"SJS\"]], \"start\": [[24, 39]], \"entity_id\": [\"T6\"]}}" } ] } ]
11207969_1
ARA-C is frequently associated with dermatologic toxicity, but this is only the second case of toxic epidermal necrolysis described in connection with this drug.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"associated\"]], \"start\": [[20]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"ARA-C\"]], \"start\": [[0]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"ARA-C\"]], \"start\": [[0]], \"entity_id\": [\"T8\"]}}, \"Effect\": {\"text\": [[\"dermatologic toxicity\"]], \"start\": [[36]], \"entity_id\": [\"T7\"]}}" } ] } ]
515777_1
Hyperglycemia and diabetic coma: possible relationship to diuretic-propranolol therapy.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"to\"]], \"start\": [[55]], \"entity_id\": [\"T7\"]}, \"Effect\": {\"text\": [[\"Hyperglycemia and diabetic coma\"]], \"start\": [[0]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"propranolol\"]], \"start\": [[67]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"propranolol\"]], \"start\": [[67]], \"entity_id\": [\"T8\"]}}}" } ] } ]
15977922_1
Potential mechanisms involved in the occurrence of ischemic colitis in patients receiving tegaserod are also discussed.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"occurrence\"]], \"start\": [[37]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"ischemic colitis\"]], \"start\": [[51]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"tegaserod\"]], \"start\": [[90]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"tegaserod\"]], \"start\": [[90]], \"entity_id\": [\"T7\"]}}, \"Subject\": {\"text\": [[\"patients\"]], \"start\": [[71]], \"entity_id\": [\"T6\"]}}" } ] } ]
9494448_2
Anaphylaxis to intravenous cyclosporine and tolerance to oral cyclosporine: case report and review.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"to\"]], \"start\": [[12]], \"entity_id\": [\"T5\"]}, \"Effect\": {\"text\": [[\"Anaphylaxis\"]], \"start\": [[0]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"intravenous cyclosporine\"]], \"start\": [[15]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"cyclosporine\"]], \"start\": [[27]], \"entity_id\": [\"T6\"]}, \"Route\": {\"text\": [[\"intravenous\"]], \"start\": [[15]], \"entity_id\": [\"T7\"]}}, \"Subject\": {\"text\": [[\"case\"]], \"start\": [[76]], \"entity_id\": [\"T8\"]}}" } ] } ]
14960440_2
CASE REPORT: A woman of 80 years, on long-term warfarin therapy presented with an acute dissecting thoracic aortic aneurysm; on investigation the only precipitating factor found was an international normalised ratio of 4.8.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"presented\"]], \"start\": [[64]], \"entity_id\": [\"T5\"]}, \"Subject\": {\"text\": [[\"A woman of 80 years\"]], \"start\": [[13]], \"entity_id\": [\"T3\"], \"Gender\": {\"text\": [[\"woman\"]], \"start\": [[15]], \"entity_id\": [\"T7\"]}, \"Age\": {\"text\": [[\"80 years\"]], \"start\": [[24]], \"entity_id\": [\"T8\"]}}, \"Treatment\": {\"text\": [[\"on long-term warfarin\"]], \"start\": [[34]], \"entity_id\": [\"T4\"], \"Duration\": {\"text\": [[\"long-term\"]], \"start\": [[37]], \"entity_id\": [\"T9\"]}, \"Drug\": {\"text\": [[\"warfarin\"]], \"start\": [[47]], \"entity_id\": [\"T10\"]}}, \"Effect\": {\"text\": [[\"acute dissecting thoracic aortic aneurysm\"]], \"start\": [[82]], \"entity_id\": [\"T6\"]}}" } ] } ]
10808214_1
A patient with an allergy to a macrolide antibiotic was given tacrolimus and developed a sudden cutaneous reaction.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[77]], \"entity_id\": [\"T6\"]}, \"Effect\": {\"text\": [[\"sudden cutaneous reaction\"]], \"start\": [[89]], \"entity_id\": [\"T7\"]}, \"Subject\": {\"text\": [[\"A patient with an allergy to a macrolide antibiotic\"]], \"start\": [[0]], \"entity_id\": [\"T3\"], \"Disorder\": {\"text\": [[\"allergy to a macrolide antibiotic\"]], \"start\": [[18]], \"entity_id\": [\"T8\"]}}, \"Treatment\": {\"text\": [[\"given tacrolimus\"]], \"start\": [[56]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"tacrolimus\"]], \"start\": [[62]], \"entity_id\": [\"T9\"]}}}" } ] } ]
9240497_2
This case suggests the importance of careful observation for extramedullary relapse in patients who are treated with ATRA.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"treated\"]], \"start\": [[104]], \"entity_id\": [\"T6\"]}, \"Effect\": {\"text\": [[\"extramedullary relapse\"]], \"start\": [[61]], \"entity_id\": [\"T3\"]}, \"Subject\": {\"text\": [[\"patients\"]], \"start\": [[87]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"ATRA\"]], \"start\": [[117]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"ATRA\"]], \"start\": [[117]], \"entity_id\": [\"T9\"]}}, \"Speculated\": {\"text\": [[\"suggests\"]], \"start\": [[10]], \"entity_id\": [\"T8\"], \"value\": true}}" } ] } ]
16863495_1
Olanzapine-associated neuroleptic malignant syndrome.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"associated\"]], \"start\": [[11]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"Olanzapine\"]], \"start\": [[0]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"Olanzapine\"]], \"start\": [[0]], \"entity_id\": [\"T6\"]}}, \"Effect\": {\"text\": [[\"neuroleptic malignant syndrome\"]], \"start\": [[22]], \"entity_id\": [\"T5\"]}}" } ] } ]
16062101_1
Acute dystonia induced by lamivudine.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[15]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"Acute dystonia\"]], \"start\": [[0]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"lamivudine\"]], \"start\": [[26]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"lamivudine\"]], \"start\": [[26]], \"entity_id\": [\"T6\"]}}}" } ] } ]
12792223_4
We report in detail an unusual adverse reaction to infliximab therapy, a drug-induced lupus-like clinical syndrome.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[78]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"infliximab\"]], \"start\": [[51]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"infliximab\"]], \"start\": [[51]], \"entity_id\": [\"T6\"]}}, \"Effect\": {\"text\": [[\"lupus-like clinical syndrome\"]], \"start\": [[86]], \"entity_id\": [\"T5\"]}}" } ] } ]
11722307_4
RESULTS: Quetiapine was associated with leucopenia in two patients and clinically apparent agranulocytosis in one patient.
true
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"associated\"]], \"start\": [[24]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"Quetiapine\"]], \"start\": [[9]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"Quetiapine\"]], \"start\": [[9]], \"entity_id\": [\"T12\"]}}, \"Effect\": {\"text\": [[\"leucopenia\"]], \"start\": [[40]], \"entity_id\": [\"T7\"]}, \"Subject\": {\"text\": [[\"two patients\"]], \"start\": [[54]], \"entity_id\": [\"T8\"], \"Population\": {\"text\": [[\"two\"]], \"start\": [[54]], \"entity_id\": [\"T9\"]}}}" }, { "event_id": "E2", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E2\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"associated\"]], \"start\": [[24]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"Quetiapine\"]], \"start\": [[9]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"Quetiapine\"]], \"start\": [[9]], \"entity_id\": [\"T12\"]}}, \"Effect\": {\"text\": [[\"clinically apparent agranulocytosis\"]], \"start\": [[71]], \"entity_id\": [\"T13\"]}, \"Subject\": {\"text\": [[\"one patient\"]], \"start\": [[110]], \"entity_id\": [\"T14\"], \"Population\": {\"text\": [[\"one\"]], \"start\": [[110]], \"entity_id\": [\"T10\"]}}}" } ] } ]
11180704_1
Oral intake and acarbose were withheld and the ileus spontaneously resolved after 2 days.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"after\"]], \"start\": [[76]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"Oral intake and acarbose\"]], \"start\": [[0]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"acarbose\"]], \"start\": [[16]], \"entity_id\": [\"T7\"]}, \"Route\": {\"text\": [[\"Oral intake\"]], \"start\": [[0]], \"entity_id\": [\"T6\"]}}, \"Effect\": {\"text\": [[\"the ileus spontaneously resolved\"]], \"start\": [[43]], \"entity_id\": [\"T4\"]}}" } ] } ]
8260059_2
No explanation for this delay was found, other than the possibility that magnesium sulfate treatment impeded lactogenesis.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"impeded\"]], \"start\": [[101]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"magnesium sulfate\"]], \"start\": [[73]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"magnesium sulfate\"]], \"start\": [[73]], \"entity_id\": [\"T6\"]}}, \"Effect\": {\"text\": [[\"lactogenesis\"]], \"start\": [[109]], \"entity_id\": [\"T5\"]}}" } ] } ]
9205466_1
Although its side effects are few, tamoxifen increases the incidence of proliferative lesions of the endometrium, which theoretically should be preventable with progestational agents.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"increases\"]], \"start\": [[45]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"tamoxifen\"]], \"start\": [[35]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"tamoxifen\"]], \"start\": [[35]], \"entity_id\": [\"T6\"]}}, \"Effect\": {\"text\": [[\"incidence of proliferative lesions of the endometrium\"]], \"start\": [[59]], \"entity_id\": [\"T4\"]}}" } ] } ]
3379435_3
Three senile patients developed fatal acute encephalopathy while receiving calcium hopantenate.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[22]], \"entity_id\": [\"T4\"]}, \"Subject\": {\"text\": [[\"Three senile patients\"]], \"start\": [[0]], \"entity_id\": [\"T3\"], \"Population\": {\"text\": [[\"Three\"]], \"start\": [[0]], \"entity_id\": [\"T7\"]}, \"Age\": {\"text\": [[\"senile\"]], \"start\": [[6]], \"entity_id\": [\"T8\"]}}, \"Effect\": {\"text\": [[\"encephalopathy\"]], \"start\": [[44]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"calcium hopantenate\"]], \"start\": [[75]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"calcium hopantenate\"]], \"start\": [[75]], \"entity_id\": [\"T10\"]}}, \"Severity\": {\"text\": [[\"fatal\"]], \"start\": [[32]], \"entity_id\": [\"T9\"], \"value\": \"Medium\"}}" } ] } ]
18515982_4
Renal injury due to anastrozole has not been published in the English literature.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"due\"]], \"start\": [[13]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"Renal injury\"]], \"start\": [[0]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"anastrozole\"]], \"start\": [[20]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"anastrozole\"]], \"start\": [[20]], \"entity_id\": [\"T6\"]}}, \"Negated\": {\"text\": [[\"not\"]], \"start\": [[36]], \"entity_id\": [\"T7\"], \"value\": true}}" } ] } ]
17420198_10
Facial, tongue, and arm movements were first reported approximately five weeks after the initiation of aripiprazole.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"after\"]], \"start\": [[79]], \"entity_id\": [\"T9\"]}, \"Treatment\": {\"text\": [[\"initiation of aripiprazole\"]], \"start\": [[89]], \"entity_id\": [\"T10\"], \"Time_elapsed\": {\"text\": [[\"five weeks\"]], \"start\": [[68]], \"entity_id\": [\"T11\"]}, \"Drug\": {\"text\": [[\"aripiprazole\"]], \"start\": [[103]], \"entity_id\": [\"T12\"]}}, \"Effect\": {\"text\": [[\"Facial, tongue, and arm movements\"]], \"start\": [[0]], \"entity_id\": [\"T8\"]}}" } ] } ]
15197722_2
Restless legs syndrome due to interferon-alpha.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"due\"]], \"start\": [[23]], \"entity_id\": [\"T5\"]}, \"Effect\": {\"text\": [[\"Restless legs syndrome\"]], \"start\": [[0]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"interferon-alpha\"]], \"start\": [[30]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"interferon-alpha\"]], \"start\": [[30]], \"entity_id\": [\"T6\"]}}}" } ] } ]
10885900_1
HUS has been reported after several anticancer chemotherapies and most often after mitomycin C-based chemotherapy regimens.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"reported\"]], \"start\": [[13]], \"entity_id\": [\"T3\"]}, \"Effect\": {\"text\": [[\"HUS\"]], \"start\": [[0]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"several anticancer chemotherapies and most often after mitomycin C-based chemotherapy regimens\"]], \"start\": [[28]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"mitomycin C\"]], \"start\": [[83]], \"entity_id\": [\"T7\"]}}}" } ] } ]
19687711_3
Although the association between SJS/TEN and the sulfonamide class of antibiotics is well established, the increasing prevalence of CA-MRSA has left practitioners with limited regimens to effectively treat skin and soft tissue infections (SSTIs) in the outpatient setting.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"association\"]], \"start\": [[13]], \"entity_id\": [\"T11\"]}, \"Treatment\": {\"text\": [[\"sulfonamide class of antibiotics\"]], \"start\": [[49]], \"entity_id\": [\"T10\"], \"Drug\": {\"text\": [[\"sulfonamide class of antibiotics\"]], \"start\": [[49]], \"entity_id\": [\"T12\"]}, \"Disorder\": {\"text\": [[\"skin and soft tissue infections (SSTIs)\"]], \"start\": [[206]], \"entity_id\": [\"T13\"]}}, \"Effect\": {\"text\": [[\"SJS/TEN\"]], \"start\": [[33]], \"entity_id\": [\"T9\"]}, \"Subject\": {\"text\": [[\"CA-MRSA\"]], \"start\": [[132]], \"entity_id\": [\"T15\"], \"Disorder\": {\"text\": [[\"CA-MRSA\"]], \"start\": [[132]], \"entity_id\": [\"T14\"]}}}" } ] } ]