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embedding_all-mpnet-base-v2
sequence
embedding_multi-qa-mpnet-base-dot-v1
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embedding_all-MiniLM-L12-v2
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25440306
3objective
Long-term follow-up studies documenting maintenance of treatment effects are fewin adolescent anorexia nervosa ( AN ) .
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25440306
3objective
This exploratory study reports relapse from full remission and attainment of remission during a @-year open follow-up period using a convenience sample of a subgroup of @ % ( n = @ ) from an original cohort of @ participants who completed a randomized clinical trial comparing family-based therapy ( FBT ) and adolescent-focused individual therapy ( AFT ) .
1
401
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25440306
2methods
Follow-up assessments were completed up to @years posttreatment ( average , @ years ) .
2
402
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25440306
2methods
Available participants completed the Eating Disorder Examination as well as self-report measures of self-esteem and depression at @ to @ years posttreatment .
3
403
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25440306
4results
Two participants ( @ % ) relapsed ( FBT : n = @ , @ % ; AFT : n = @ , @ % ) , on average @ years ( SD = @ years ) after remission was achieved at @-year follow-up .
4
404
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25440306
4results
Ten new participants ( @ % ) achieved remission ( FBT : n = @ , @ % ; AFT : n = @ , @ % ) .
5
405
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25440306
4results
Mean time to remission for this group was @ years ( SD = @ years ) from @-year follow-up .
6
406
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25440306
4results
There were no differences based on treatment group assignment in either relapse from full remission or new remission during long-term follow-up .
7
407
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25440306
4results
Other psychopathology was stable over time .
8
408
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25440306
1conclusions
There were few changes in the clinical presentation of participants who were assessed at long-term follow-up .
9
409
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25440306
1conclusions
These data suggest that outcomes are generally stable posttreatment regardless of treatment type once remission is achieved .
10
410
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25440306
1conclusions
Clinical trial registration information-Effectiveness of Family-Based Versus Individual Psychotherapy in Treating Adolescents With Anorexia Nervosa ; http://www.clinicaltrials.gov/; NCT@ .
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24754891
0background
Coronary artery bypass grafting using the radial artery has , since the @s , gone through a revival .
0
412
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24754891
0background
Observational studies have indicated better long-term patency when using radial arteries .
1
413
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24754891
0background
Therefore , radial artery might be preferred especially in younger patients where long time patency is important .
2
414
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24754891
0background
During the last @years different endoscopic techniques to harvest the radial artery have evolved .
3
415
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24754891
0background
Endoscopic radial artery harvest only requires a small incision near the wrist in contrast to open harvest , which requires an incision from the elbow to the wrist .
4
416
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24754891
0background
However , it is unknown whether the endoscopic technique results in fewer complications or a graft patency comparable to open harvest .
5
417
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24754891
0background
When the radial artery has been harvested , there are two ways to use the radial artery as a graft .
6
418
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24754891
0background
One way is sewing it onto the aorta and another is sewing it onto the mammary artery .
7
419
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24754891
0background
It is unknown which technique is the superior revascularisation technique .
8
420
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24754891
2methods
The NEO Trial is a randomised clinical trial with a @ factorial design .
9
421
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24754891
2methods
We plan to randomise @ participants into four intervention groups : ( @ ) mammario-radial endoscopic group ; ( @ ) aorto-radial endoscopic group ; ( @ ) mammario-radial open surgery group ; and ( @ ) aorto-radial open surgery group.The hand function will be assessed by a questionnaire , a clinical examination , the change in cutaneous sensibility , and the measurement of both sensory and motor nerve conduction velocity at @months postoperatively .
10
422
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24754891
2methods
All the postoperative complications will be registered , and we will evaluate muscular function , scar appearance , vascular supply to the hand , and the graft patency including the patency of the central radial artery anastomosis .
11
423
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24754891
2methods
A patency evaluation by multi-slice computer tomography will be done at one year postoperatively.We expect the nerve conduction studies and the standardised neurological examinations to be able to discriminate differences in hand function comparing endoscopic to open harvest of the radial artery .
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24754891
2methods
The trial also aims to show if there is any patency difference between mammario-radial compared to aorto-radial revascularisation techniques but this objective is exploratory .
13
425
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24284437
0background
Knowledge of essential amino acid requirements in infants is important because excessive intake of protein can lead to increased long-term morbidity such as obesity .
0
426
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24284437
0background
A deficient intake may lead to suboptimal growth and impaired neurodevelopment .
1
427
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24284437
0background
The current recommended branched-chain amino acid requirements in infants aged @-@ mo are based on the amino acid content of human milk .
2
428
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24284437
3objective
We quantified the requirements for isoleucine , leucine , and valine for term neonates by using the indicator amino acid oxidation method with -LSB- @ - ( @ ) C -RSB- phenylalanine as the indicator .
3
429
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24284437
2methods
Fully enterally fed term infants received randomly graded amounts of isoleucine ( @-@ mg kg ( -@ ) d ( -@ ) ) , leucine ( @-@ mg kg ( -@ ) d ( -@ ) ) , or valine ( @-@ mg kg ( -@ ) d ( -@ ) ) as part of an elemental formula .
4
430
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24284437
2methods
Data are expressed as means SDs .
5
431
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24284437
4results
Eighty-three Asian , term neonates ( mean SD birth weight : @ @ kg ; gestational age : @ @ wk ) were studied at a postnatal age of @ @ d. Mean requirements for isoleucine , leucine , and valine ( measured in boys only ) were @ mg kg ( -@ ) d ( -@ ) ( r ( @ ) = @ , P < @ ) , @ mg kg ( -@ ) d ( -@ ) ( r ( @ ) = @ , P < @ ) , and @ mg kg ( -@ ) d ( -@ ) ( r ( @ ) = @ , P = @ ) , respectively .
6
432
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24284437
1conclusions
Current human milk-based recommendations for isoleucine and valine in term infants aged @-@ mo are correct .
7
433
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24284437
1conclusions
However , the current recommendation for leucine ( @ mg kg ( -@ ) d ( -@ ) ) is higher than the mean requirement of @ mg kg ( -@ ) d ( -@ ) that we determined in this study .
8
434
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24284437
1conclusions
This trial was registered at www.trialregister.nl as NTR@ .
9
435
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25585779
3objective
We wanted to confirm the benefit of mometasone furoate ( MF ) in preventing acute radiation reactions , as shown in a previous study ( Bostrm et al , Radiother Oncol @ ; @:@ -@ ) .
0
436
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25585779
2methods
The study was a double-blind comparison of MF with D ( Diprobase ) , administered daily from the start of radiation therapy for @ weeks in patients receiving breast radiation therapy , @ Gy in @-Gy fractions daily over @ weeks .
1
437
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25585779
2methods
The primary endpoint was mean modified Radiation Therapy Oncology Group ( RTOG ) score .
2
438
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25585779
4results
Mean RTOG scores were significantly less for MF than for D ( P = @ ) .
3
439
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25585779
4results
Maximum RTOG and mean erythema scores were significantly less for MF than for D ( P = @ and P = @ , respectively ) .
4
440
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25585779
4results
The Dermatology Life Quality Index ( DLQI ) score was significantly less for MF than for D at weeks @ and @ when corrected for Hospital Anxiety and Depression ( HAD ) questionnaire scores .
5
441
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25585779
1conclusions
MF cream significantly reduces radiation dermatitis when applied to the breast during and after radiation therapy .
6
442
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25585779
1conclusions
For the first time , we have shown a significantly beneficial effect on quality of life using a validated instrument ( DLQI ) , for a topical steroid cream .
7
443
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25585779
1conclusions
We believe that application of this cream should be the standard of care where radiation dermatitis is expected .
8
444
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24332668
3objective
To compare the interstage cardiac catheterization hemodynamic and angiographic findings between shunt types for the Pediatric Heart Network Single Ventricle Reconstruction trial .
0
445
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24332668
3objective
The trial , which randomized subjects to a modified Blalock-Taussig shunt ( MBTS ) or right ventricle-to-pulmonary artery shunt ( RVPAS ) for the Norwood procedure , demonstrated the RVPAS was associated with a smaller pulmonary artery diameter but superior @-month transplant-free survival .
1
446
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24332668
2methods
We analyzed the pre-stage II catheterization data for the trial subjects .
2
447
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24332668
2methods
The hemodynamic variables and shunt and pulmonary angiographic data were compared between shunt types ; their association with @-month transplant-free survival was also evaluated .
3
448
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24332668
4results
Of @ randomized subjects , @ underwent pre-stage II catheterization .
4
449
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24332668
4results
A smaller size , lower aortic and superior vena cava saturation , and higher ventricular end-diastolic pressure were associated with worse @-month transplant-free survival .
5
450
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24332668
4results
The MBTS group had a lower coronary perfusion pressure ( @ vs @ mm Hg ; P < @ ) and greater pulmonary blood flow/systemic blood flow ratio ( @ vs @ , P = @ ) .
6
451
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24332668
4results
A greater pulmonary blood flow/systemic blood flow ratio increased the risk of death or transplantation only in the RVPAS group ( P = @ ) .
7
452
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24332668
4results
The MBTS group had fewer shunt ( @ % vs @ % , P = @ ) and severe left pulmonary artery ( @ % vs @ % , P = @ ) stenoses , larger mid-main branch pulmonary artery diameters , and greater Nakata indexes ( @ vs @ , P < @ ) .
8
453
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24332668
1conclusions
Compared with the RVPAS subjects , the MBTS subjects had more hemodynamic abnormalities related to shunt physiology , and the RVPAS subjects had more shunt or pulmonary obstruction of a severe degree and inferior pulmonary artery growth at pre-stage II catheterization .
9
454
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24332668
1conclusions
A lower body surface area , greater ventricular end-diastolic pressure , and lower superior vena cava saturation were associated with worse @-month transplant-free survival .
10
455
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24379356
3objective
It has been hypothesized that the development of diabetic polyneuropathy ( DPN ) is due to swelling of the nerve , as well as thickening and stiffening of the surrounding ligaments , causing chronic compression of nerves .
0
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24379356
3objective
We aimed to examine the effect of surgical decompression of the tibial nerve on the mean cross-sectional area ( CSA ) .
1
457
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24379356
2methods
We performed a randomized controlled trial of @ subjects with painful DPN diagnosed using the Diabetic Neuropathy Score .
2
458
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24379356
2methods
A computer randomized for the surgery arm of the study .
3
459
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24379356
2methods
A control group consisting of @ healthy subjects was included .
4
460
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24379356
2methods
An experienced sonographer measured the CSA and thickness-to-width ( T/W ) ratio of the tibial nerve , as well as the thickness of the flexor retinaculum .
5
461
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24379356
4results
CSA is significantly larger in patients with painful DPN ( @ @ mm ( @ ) ) than in control subjects ( @ @ mm ( @ ) ) , P = @ .
6
462
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24379356
4results
The T/W ratio in patients with painful DPN is @ and in control subjects @ , P = @ .
7
463
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24379356
4results
Patients with DPN have a significantly thicker retinaculum ( @ mm ) than control subjects ( @ mm ) , P < @ .
8
464
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24379356
4results
Mean follow-up was @ weeks ( range @-@ ) .
9
465
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24379356
4results
Difference between baseline and follow-up in the operated leg was @ mm ( @ ) and in the control leg @ mm ( @ ) , P = @ .
10
466
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24379356
1conclusions
Decompression of the tibial nerve does not result in a significant difference between baseline and follow-up in CSA using ultrasound between the operated and control leg .
11
467
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24379356
1conclusions
Ultrasound measurements show a significantly increased CSA , a significantly thicker retinaculum , and a significantly increased T/W ratio in patients with painful DPN compared with healthy control subjects .
12
468
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24379356
1conclusions
Clinical trial reg .
13
469
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24379356
1conclusions
no .
14
470
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24379356
1conclusions
NTR@ , www.trialregister.nl .
15
471
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25018097
0background
A community-based randomized trial was conducted in Costa Rica to evaluate the HPV-@ / @ AS@-adjuvanted vaccine ( NCT@ ) .
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472
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25018097
0background
The primary objective was to evaluate efficacy of the vaccine to prevent cervical intraepithelial neoplasia @ or more severe disease ( CIN@ + ) associated with incident HPV-@ / @ cervical infections .
1
473
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25018097
0background
Secondary objectives were to evaluate efficacy against CIN@ + associated with incident cervical infection by any oncogenic HPVs and to evaluate duration of protection against incident cervical infection with HPV-@ / @ .
2
474
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25018097
0background
Vaccine safety and immunogenicity over the @-year follow-up were also evaluated .
3
475
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25018097
2methods
We randomized ( @ HPV arm ; @ control arm ) , vaccinated ( HPV-@ / @ or Hepatitis A ) and followed ( median @ months ) @ healthy women aged @-@ years .
4
476
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25018097
2methods
@ women ( @ HPV arm ; @ control arm ) were included in the according to protocol analysis for efficacy .
5
477
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25018097
2methods
The full cohort was evaluated for safety .
6
478
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25018097
2methods
Immunogenicity was considered on a subset of @ ( HPV-@ ) and @ ( HPV-@ ) women .
7
479
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25018097
2methods
HPV type was assessed by PCR on cervical specimens .
8
480
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25018097
2methods
Immunogenicity was assessed using ELISA and inhibition enzyme immunoassays .
9
481
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25018097
2methods
Disease outcomes were histologically confirmed .
10
482
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25018097
2methods
Vaccine efficacy and @ % confidence intervals ( @ % CI ) were computed .
11
483
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25018097
4results
Vaccine efficacy was @ % ( @ % CI : @-@ @ ; N = @ events total ) against HPV-@ / @ associated CIN@ + , @ % ( @ % CI : @-@ @ ; N = @ events total ) against CIN@ + associated with non-HPV-@ / @ oncogenic HPVs and @ % ( @ % CI : @-@ @ ; N = @ events total ) against CIN@ + irrespective of HPV type .
12
484
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25018097
4results
The vaccine had an acceptable safety profile and induced robust and long-lasting antibody responses .
13
485
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25018097
1conclusions
Our findings confirm the high efficacy and immunogenicity of the HPV-@ / @ vaccine against incident HPV infections and cervical disease associated with HPV-@ / @ and other oncogenic HPV types .
14
486
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25018097
1conclusions
These results will serve as a benchmark to which we can compare future findings from the ongoing extended follow-up of participants in the Costa Rica trial .
15
487
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24736930
0background
There is a long-held concept among spine surgeons that endoscopic lumbar discectomy procedures are reserved for small-contained disc herniation ; @-year follow-up has not been reported .
0
488
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24736930
0background
The purpose of this study is to assess microendoscopic discectomy ( MED ) in patients with large uncontained lumbar disc herniation ( the antero-posterior diameter of the extruded fragment is @-@ mm or more on axial cuts of MRI ) and report long-term outcome .
1
489
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24736930
2methods
One hundred eighty-five patients with MED or standard open discectomy underwent follow-up for @ years .
2
490
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24736930
2methods
Primary ( clinical ) outcomes data included Numerical Rating Scale ( NRS ) for back and leg symptoms and Oswestry Disability Index ( ODI ) to quantify pain and disability , respectively .
3
491
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24736930
2methods
Secondary ( objective ) outcomes data included operative time , blood loss , postoperative analgesics , length of hospital stay , time to return to work , reoperation and complication rate , patient satisfaction index ( PSI ) , and modified ( MacNab ) criteria .
4
492
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24736930
4results
At the end of the follow-up , the leg pain relief was statistically significant for both groups .
5
493
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24736930
4results
NRS back pain , ODI , PSI and MacNab criteria showed significant deterioration for control group .
6
494
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24736930
4results
Secondary outcomes data of MED group were significantly better than the control group .
7
495
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24736930
1conclusions
Large , uncontained , lumbar disc herniations can be sufficiently removed using MED which is an effective alternative to open discectomy procedures with remarkable long-term outcome .
8
496
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24736930
1conclusions
Although the neurological outcome of the two procedures is the same , the morbidity of MED is significantly less than open discectomy .
9
497
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24736930
1conclusions
Maximum benefit can be gained if we adhere to strict selection criteria .
10
498
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24736930
1conclusions
The optimum indication is single - or multi-level radiculopathy secondary to a single-level , large , uncontained , lumbar disc herniation .
11
499
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