abstract_id
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8
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class label
5 classes
text
stringlengths
1
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sentence_id
int64
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int64
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embedding_all-mpnet-base-v2
sequence
embedding_multi-qa-mpnet-base-dot-v1
sequence
embedding_all-MiniLM-L12-v2
sequence
25318787
2methods
A total of @ consecutive STEMI patients were prospectively and randomly assigned into two groups : @ patients in the RH group and @ patients in the no RH ( control ) group .
1
200
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25318787
2methods
The serum creatinine ( SCr ) and creatinine clearance ( CCr ) levels were measured on admission and at @ , @ and @ hours after primary PCI .
2
201
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25318787
2methods
The rates of CIN and short-term adverse events were analyzed for each group .
3
202
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25318787
2methods
After surgery , the patients were categorized into four groups according to the Mehran risk score : low ( @ , n = @ ) , moderate ( @-@ , n = @ ) , high ( @-@ , n = @ ) or very high ( @ , n = @ ) .
4
203
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25318787
4results
The incidence of CIN in the RH group was lower than that observed in the control group ( @/@ ; @ % vs. @/@ ; @ % , p < @ ) .
5
204
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25318787
4results
The subgroup analysis showed that the rate of CIN was lower in the moderate ( @/@ ; @ % vs. @/@ ; @ % , p < @ ) and significantly lower in both the high ( @/@ ; @ % vs. @/@ ; @ % , p < @ ) and very high score groups ( @/@ ; @ % vs. @/@ ; @ % , p < @ ) among the RH patients compared to the controls .
6
205
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25318787
4results
At @ , @ and @ hours after PCI , the patients in the RH group exhibited lower SCr levels and higher CCr levels than the patients in the control group ( both p < @ ) .
7
206
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25318787
4results
A lower incidence of in-hospital clinical events was also observed in the RH group .
8
207
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25318787
1conclusions
Remedial hydration decreases the occurrence of CIN and improves the short-term prognosis of STEMI patients undergoing primary PCI .
9
208
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24396280
0background
An increased production of oxidizing species related to reactive oral diseases , such as chronic apical periodontitis , could have systemic implications such as an increase in cardiovascular morbidity .
0
209
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24396280
0background
Based on this consideration , we conducted a prospective study to assess whether subjects affected by chronic periodontitis presented with higher values of oxidative stress than reference values before endodontic treatment , and whether endodontic treatment can reduce the oxidative imbalance and bring it back to normal in these subjects .
1
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24396280
2methods
The authors recruited @ groups of patients from private studies and dental clinics : these patients were recruited randomly .
2
211
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24396280
2methods
The oxidative balance in both patients with chronic apical periodontitis ( CAP ) and healthy control patients was determined by measuring the oxidant status , using an identification of the reactive oxygen metabolites ( d-ROMs ) test , while the antioxidant status in these patients was determined using a biological antioxidant potential ( BAP ) test .
3
212
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24396280
2methods
Both these tests were carried on plasma samples taken from enrolled patients .
4
213
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24396280
2methods
Values were measured both before the endodontic treatment of the patients with chronic apical periodontitis , and @ and @ days after treatment , and compared to those obtained from healthy control patients .
5
214
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24396280
4results
It was found that , on recruitment , the patients with chronic apical periodontitis exhibited significantly higher levels of oxidative stress than control patients , as determined by the d-ROMs and BAP tests .
6
215
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24396280
4results
Furthermore , the d-ROMs test values were shown to decrease and the BAP test values to increase over time in patients with chronic apical periodontitis following endodontic therapy .
7
216
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24396280
4results
As the levels of oxidative stress in these patients tended to reduce and return to normal by @ days following treatment .
8
217
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24396280
1conclusions
This study has demonstrated a positive association between chronic apical periodontitis and oxidative stress .
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24396280
1conclusions
Subjects affected by chronic apical periodontitis are exposed to a condition of oxidative stress , which is extremely dangerous to general health .
10
219
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24396280
1conclusions
Moreover , one can infer from these findings that through proper endodontic therapy , a good oxidative balance can be restored , thereby avoiding the risk of contracting the abovementioned diseases .
11
220
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24731889
0background
Placebo effect has been largely studied and debated in medicine .
0
221
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24731889
0background
Research focused mainly on children and adults but not on newborns .
1
222
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24731889
0background
In osteopathy , few studies documented this effect and no research has been conducted in newborns .
2
223
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24731889
3objective
To assess the presence of placebo effect in newborns using sham osteopathic manipulative treatment .
3
224
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24731889
2methods
Randomized control trial .
4
225
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24731889
2methods
Neonatal Intensive Care Unit in Italy .
5
226
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24731889
2methods
Two groups ( @ patients each ) of preterm infants aged @-@ weeks without medical complications received routine pediatric care and osteopathic sham therapy was administrated to the study group only for the entire period of hospitalization .
6
227
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24731889
2methods
Primary end point was the mean reduction of length of stay at discharge .
7
228
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24731889
2methods
Secondary objective was the change in daily weight gain .
8
229
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24731889
4results
@ newborns entered the study .
9
230
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24731889
4results
No difference between sham and control group was found for the primary outcome length of stay ( @ ; @ ; p = @ ) .
10
231
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24731889
4results
Multivariate analysis showed no difference between study and control group on length of stay .
11
232
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24731889
4results
A negative association was found for gestational age ( -@ ; @ % CI -@ to -@ ; p = @ ) , birth weight ( -@ ; @ % CI -@ to -@ ; p < @ ) and milk volume at study enrollment ( -@ ; @ % CI -@ to -@ ; p = @ ) .
12
233
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24731889
1conclusions
To the best of our knowledge , this study is the first in the field showing no placebo effect on newborns .
13
234
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24731889
1conclusions
Further discussions are opened concerning the age when placebo effect starts .
14
235
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25880933
0background
Clostridium difficile infection ( CDI ) is a leading cause of diarrhoea in health care settings with symptoms ranging from mild and self-limiting to life threatening .
0
236
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25880933
0background
SMT@ is a novel , non-absorbable antibiotic currently under development for the treatment of CDI .
1
237
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25880933
0background
Here we report the results from a Phase I study .
2
238
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25880933
2methods
A double-blind , randomized , placebo-controlled study assessing safety and tolerability of single and multiple oral doses of SMT@ in healthy volunteers .
3
239
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25880933
2methods
Pharmacokinetic assessments included blood and faecal sampling .
4
240
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25880933
2methods
The effect of food on systemic exposure and analysis of the gut microbiota were also included .
5
241
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25880933
4results
Fifty-six healthy male subjects were enrolled .
6
242
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25880933
4results
Following single oral doses of up to @,@ mg in the fasted state , plasma concentrations of SMT@ were generally below the lower limit of quantification .
7
243
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25880933
4results
In the fed state levels ranged from @ to @ ng/mL after single dosing and after repeat dosing at Day @ from @ to @ ng/mL .
8
244
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25880933
4results
Following single and multiple oral doses of SMT@ , mean daily faecal concentrations increased with increasing dose level and were significantly above the typical MIC range for C. difficile ( @-@ @ g/mL ) .
9
245
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25880933
4results
At @ mg BID , mean ( SD ) faecal concentrations of @,@ ( @ ) g/g and @,@ ( @ ) g/g were determined on days @ and @ of dosing respectively .
10
246
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25880933
4results
No notable metabolites were detected in faeces .
11
247
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25880933
4results
Overall , all doses of SMT@ were well tolerated both as single oral doses or BID oral doses for @ days .
12
248
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25880933
4results
The majority ( @ % ) of adverse events ( AEs ) were classified as gastrointestinal disorders and were mild in severity , resolving without treatment .
13
249
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25880933
4results
The gut microbiota was analysed in the multiple dose groups with minimal changes observed in the bacterial groups analysed except for total clostridia which were reduced to below the limit of detection by day @ of dosing .
14
250
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25880933
1conclusions
Oral administration of SMT@ was considered safe and well tolerated and was associated with negligible plasma concentrations after single and multiple doses .
15
251
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25880933
1conclusions
In addition , minimal disruption of normal gut microbiota was noted , confirming the highly selective spectrum of the compound .
16
252
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25880933
1conclusions
These results support the further clinical development of SMT@ as an oral therapy for CDI .
17
253
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25231496
0background
While overall survival for most common cancers in Australia is improving , the rural-urban differential has been widening , with significant excess deaths due to lung , colorectal , breast and prostate cancer in regional Australia .
0
254
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25231496
0background
Internationally a major focus on understanding variations in cancer outcomes has been later presentation to healthcare and later diagnosis .
1
255
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25231496
0background
Approaches to reducing time to diagnosis of symptomatic cancer include public symptom awareness campaigns and interventions in primary care to improve early cancer detection .
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25231496
0background
This paper reports the protocol of a factorial cluster-randomised trial of community and general practice ( GP ) level interventions to reduce the time to diagnosis of cancer in rural Western Australia ( WA ) .
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25231496
2methods
The community intervention is a symptom awareness campaign tailored for rural Australians delivered through a community engagement model .
4
258
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25231496
2methods
The GP intervention includes a resource card with symptom risk assessment charts and local referral pathways implemented through multiple academic detailing visits and case studies .
5
259
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25231496
2methods
Participants are eligible if recently diagnosed with breast , colorectal , lung or prostate cancer who reside in specific regions of rural WA with a planned sample size of @ .
6
260
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25231496
2methods
The primary outcome is the Total Diagnostic Interval , defined as the duration from first symptom ( or date of cancer screening test ) to cancer diagnosis .
7
261
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25231496
2methods
Secondary outcomes include cancer stage , healthcare utilisation , disease-free status , survival at @ and @years and cost-effectiveness .
8
262
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25231496
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Ethics approval has been granted by the University of Western Australia and from all relevant hospital recruitment sites in WA .
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25231496
4results
Results of this trial will be reported in peer-reviewed publications and in conference presentations .
10
264
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26024687
0background
This study aimed to evaluate whether incidental CT findings of emphysema , airway thickening and bronchiectasis , as seen on CT scans performed for other non-pulmonary clinical indications , are associated with future acute exacerbations of COPD resulting in hospitalisation or death .
0
265
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26024687
2methods
This multicentre prospective case-cohort study comprised @ subjects who underwent routine diagnostic chest CT for non-pulmonary indications .
1
266
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26024687
2methods
Using a case-cohort approach , we visually graded CT scans from cases and a random sample of @ % of the baseline cohort ( n = @ ) for emphysema severity ( range @-@ ) , airway thickening ( range @-@ ) and bronchiectasis ( range @-@ ) .
2
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26024687
2methods
We used weighted Cox proportional hazards analysis to assess the independent association between CT findings and hospitalisation or death due to COPD exacerbation .
3
268
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26024687
4results
During a median follow-up of @ years ( maximum @ years ) , @ COPD events were identified .
4
269
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26024687
4results
The risk of experiencing a future acute exacerbation of COPD resulting in hospitalisation or death was significantly increased in subjects with severe emphysema ( score @ ) and severe airway thickening ( score @ ) .
5
270
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26024687
4results
The respective HRs were @ ( @ % CI @ to @ ) and @ ( @ % CI @ to @ ) .
6
271
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26024687
4results
Severe bronchiectasis ( score @ ) was not significantly associated with increased risk of adverse events ( HR @ ; @ % CI @ to @ ) .
7
272
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26024687
1conclusions
Morphological correlates of COPD such as emphysema and airway thickening detected on CT scans obtained for other non-pulmonary indications are strong independent predictors of subsequent development of acute exacerbations of COPD resulting in hospitalisation or death .
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24851690
3objective
To explore the feasibility of making a preoperative diagnosis of lung adenocarcinoma shown as ground-glass nodule ( GGN ) on computed tomography ( CT ) .
0
274
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24851690
2methods
A total of @ GGN lesions proved pathologically were divided randomly into A and B groups .
1
275
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24851690
2methods
Then each group was further divided pathologically into preinvasive lesion , minimal invasive adenocarcinoma ( MIA ) and invasive adenocarcinoma ( IAC ) subgroups .
2
276
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24851690
2methods
Group A ( n = @ ) , size of lesion , proportion of ground glass opacity ( GGO ) composition of lesion , long diameter , longest diameter and size of solid component in lesion were measured on CT so as to establish the CT diagnostic standard of lung adenocarcinoma shown as GGN on CT. .
3
277
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24851690
2methods
Group B ( n = @ ) was employed to evaluate the accuracy of the above CT diagnostic standard .
4
278
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24851690
2methods
SPSS @ software was used for statistical analysis .
5
279
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24851690
4results
Significant statistic significance existed in all parameters among all groups ( P < @ ) .
6
280
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24851690
4results
All parameters were correlated the pathologic type of lesion .
7
281
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24851690
4results
The differences were statistically significant ( P = @ ) .
8
282
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24851690
4results
Through the receiver operating characteristic ( ROC ) curve , between groups of preinvasive lesion and MIA , each parameter had a medium diagnostic value of @-@ @ ; between groups of MIA and IAC , size of lesion and long diameter of solid component in lesion had a medium diagnostic value of @-@ @ , longest diameter of solid component , size of solid component in lesion and proportion of GGO composition of lesion had a high diagnostic value with an AUC of > @ .
9
283
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24851690
4results
The CT diagnostic standard , derived from group A , was used to analyze the pathologic type of group B. And t no significant statistic significance existed between CT preoperative diagnosis and operative pathologic diagnosis ( P > @ ) .
10
284
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24851690
4results
The correct diagnosis rates of size of lesion , proportion of GGO composition of lesion , long diameter , longest diameter and size of solid component in lesion were @ % , @ % , @ % , @ % and @ % respectively .
11
285
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24851690
1conclusions
Based upon size of lesion , proportion of GGO composition of lesion , long diameter , longest diameter and size of solid component in lesion , preoperative CT examination may be used to determine the pathological types of lung adenocarcinoma shown as GGN .
12
286
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25883103
3objective
Tonsillectomy surgery is associated with severe postoperative pain that usually requires analgesics including opioids .
0
287
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25883103
3objective
Pain control is still a big problem after tonsillectomy surgery .
1
288
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25883103
3objective
We aimed to evaluate the efficacy of preemptive analgesia using montelukast for pediatric post-tonsillectomy pain management .
2
289
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25883103
3objective
This is the first-time use of montelukast in post-tonsillectomy pain .
3
290
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25883103
2methods
Double-blind , controlled-randomized study .
4
291
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25883103
2methods
University teaching and research hospital .
5
292
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25883103
2methods
A total of @ children , aged @ to @ years , American Society of Anesthesiologist class I-II , scheduled for elective tonsillectomy were enrolled in this clinical trial study .
6
293
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25883103
2methods
The patients were randomized into @ groups : the montelukast group ( group M , n = @ ) and control group ( group C , n = @ ) .
7
294
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25883103
2methods
Group M recieved an oral montelukast tablet and group C recieved placebo at @pm on the morning before surgery .
8
295
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25883103
2methods
Post-tonsillectomy pain was evaluated with the Wong-Baker FACES Scale during the @ hours after surgery .
9
296
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25883103
2methods
Patients ' intraoperative hemodynamic parameters and intraoperative and postoperative complications were recorded .
10
297
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25883103
4results
There were statistically significant differences between group C and group M for Wong-Baker FACES pain rating scale scores ( P < @ ) .
11
298
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25883103
4results
In the @ hours after surgery , the total number of patients using rescue analgesics was higher in group C than in group M , and the difference was statistically significant ( P < @ ) .
12
299
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