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embedding_all-mpnet-base-v2
sequence
embedding_multi-qa-mpnet-base-dot-v1
sequence
embedding_all-MiniLM-L12-v2
sequence
24990004
1conclusions
Medical education should emphasize the need for physical medicine and rehabilitative care among individuals with MS , the ability of physiatrists to improve the functional status and quality of life for MS patients , and the team-based nature of MS care .
7
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25761501
0background
Lysine requirements of well-nourished children from developing regions have been found to be similar to those of children from developed regions ( @ mgkgd ) .
0
176,101
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25761501
0background
However , intestinal parasites have been shown to increase lysine requirements in undernourished adults , and it is not known if a similar phenomenon occurs in undernourished children from poor and unsanitary environments .
1
176,102
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25761501
3objective
Our objective was to measure the lysine requirement of moderately undernourished school-aged Indian children by the indicator amino acid oxidation technique before and after successful treatment for intestinal parasites .
2
176,103
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25761501
2methods
Twenty-one undernourished school-aged children ( @ y of age ) with z scores between -@ SD and -@ SD for height-for-age or weight-for-age , who tested positive for intestinal parasites , were studied before and after successful antiparasite treatment .
3
176,104
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25761501
2methods
Children were fed any @ of @ levels of lysine intakes ( @ , @ , @ , @ , @ , @ , and @ mgkgd ) in random order .
4
176,105
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25761501
2methods
The lysine requirement was determined by applying a @-phase linear regression crossover analysis on the fractional oxidation rate of the tracer L - -LSB- @-C -RSB- phenylalanine in response to the graded lysine intakes .
5
176,106
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25761501
4results
The lysine requirement of undernourished children with intestinal parasite infestations was determined to be @ mgkgd ( @ % CI : @ , @ mgkgd ) , and after successful antiparasitic treatment it was determined to be @ mgkgd ( @ % CI : @ , @ mgkgd ) .
6
176,107
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25761501
4results
The results were significantly different ( P < @ ) , although the @ % CIs overlapped .
7
176,108
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25761501
1conclusions
The lysine requirement in undernourished children is similar to that of well-nourished children , and intestinal parasitic infestation increased the lysine requirement by @ % .
8
176,109
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24259978
3objective
To compare the efficacy and side effects of low-dose amitriptyline ( AMT ) with proton pump inhibitor treatment in patients with globus pharyngeus .
0
176,110
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24259978
2methods
Thirty-four patients who fulfilled the Rome III criteria for functional esophageal disorders were included in this study .
1
176,111
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24259978
2methods
Patients were randomly assigned to receive either @ mg AMT before bedtime ( AMT group ) or @ mg Pantoprazole once daily for @ wk ( conventional group ) .
2
176,112
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24259978
2methods
The main efficacy endpoint was assessed using the Glasgow Edinburgh Throat Scale ( GETS ) .
3
176,113
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24259978
2methods
The secondary efficacy endpoints included the Medical Outcomes Study @-item short form health survey -LSB- social functioning ( SF ) -@ -RSB- and the Pittsburgh Sleep Quality Index .
4
176,114
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24259978
2methods
Treatment response was defined as a > @ % reduction in GETS scores .
5
176,115
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24259978
2methods
All patients entering this study recorded side effects at days @ , @ , @ , @ and @ using a visual analogue scale .
6
176,116
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24259978
4results
Thirty patients completed the study .
7
176,117
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24259978
4results
After @ wk of treatment , the AMT group had a greater response than the conventional group ( @ % vs @ % , P = @ ) .
8
176,118
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24259978
4results
At day @ , the AMT group showed significantly more improvement than the Conventional group in GETS score ( @ @ vs @ @ , P = @ ) .
9
176,119
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24259978
4results
After @ wk of treatment , the AMT group showed significantly greater improvement in GETS score and sleep quality than the Conventional group ( @ @ vs @ @ , @ @ vs @ @ ; P < @ for both ) .
10
176,120
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24259978
4results
Additionally , the AMT group was more likely than the Conventional group to experience improvement in the SF-@ , including general health , vitality , social functioning and mental health ( P = @ , @ , @ and @ ) .
11
176,121
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24259978
4results
Dry mouth , sleepiness , dizziness and constipation were the most common side effects .
12
176,122
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24259978
1conclusions
Low-dose AMT is well tolerated and can significantly improve patient symptoms , sleep and quality of life .
13
176,123
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24259978
1conclusions
Thus , low-dose AMT may be an effective treatment for globus pharyngeus .
14
176,124
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25817373
0background
Up to now , all tested Ebola virus vaccines have been based on the virus strain from the Zaire outbreak in @ .
0
176,125
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25817373
0background
We aimed to assess the safety and immunogenicity of a novel recombinant adenovirus type-@ vector-based Ebola vaccine expressing the glycoprotein of the @ epidemic strain .
1
176,126
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25817373
2methods
We did this randomised , double-blind , placebo-controlled , phase @ clinical trial at one site in Taizhou County , Jiangsu Province , China .
2
176,127
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25817373
2methods
Healthy adults ( aged @-@ years ) were sequentially enrolled and randomly assigned ( @:@ ) , by computer-generated block randomisation ( block size of six ) , to receive placebo , low-dose adenovirus type-@ vector-based Ebola vaccine , or high-dose vaccine .
3
176,128
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25817373
2methods
Randomisation was pre-stratified by dose group .
4
176,129
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25817373
2methods
All participants , investigators , and laboratory staff were masked to treatment allocation .
5
176,130
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25817373
2methods
The primary safety endpoint was occurrence of solicited adverse reactions within @ days of vaccination .
6
176,131
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25817373
2methods
The primary immunogenicity endpoints were glycoprotein-specific antibody titres and T-cell responses at day @ after the vaccination .
7
176,132
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25817373
2methods
Analysis was by intention to treat .
8
176,133
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25817373
2methods
The study is registered with ClinicalTrials.gov , number NCT@ .
9
176,134
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25817373
4results
Between Dec @ , @ , and Jan @ , @ , @ participants were enrolled and randomly assigned to receive placebo ( n = @ ) , low-dose vaccine ( n = @ ) , or high-dose vaccine .
10
176,135
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25817373
4results
Participants were followed up for @ days .
11
176,136
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25817373
4results
Overall , @ ( @ % ) participants reported at least one solicited adverse reaction within @ days of vaccination ( n = @ in the placebo group vs n = @ in the low-dose group vs n = @ in the high-dose group ; p = @ ) .
12
176,137
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25817373
4results
The most common reaction was mild pain at the injection site , which was reported in eight ( @ % ) participants in the placebo group , @ ( @ % ) participants in the low-dose group , and @ ( @ % ) participants in the high-dose vaccine group ( p < @ ) .
13
176,138
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25817373
4results
We recorded no statistical differences in other adverse reactions and laboratory tests across groups .
14
176,139
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25817373
4results
Glycoprotein-specific antibody titres were significantly increased in participants in the low-dose and high-dose vaccine groups at both day @ ( geometric mean titre @ -LSB- @ % CI @-@ -RSB- and @ -LSB- @-@ -RSB- , respectively ; p < @ ) and day @ ( @ -LSB- @-@ -RSB- and @ -LSB- @-@ -RSB- , respectively ; p < @ ) .
15
176,140
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25817373
4results
T-cell responses peaked at day @ at a median of @ spot-forming cells ( IQR @-@ ) in participants in the low-dose group and @ cells ( @-@ ) in those in the high-dose group .
16
176,141
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25817373
4results
@ ( @ % ) participants had mild fever ( n = @ in the placebo group , n = @ in the low-dose group , and n = @ in the high-dose group ) .
17
176,142
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25817373
4results
No serious adverse events were recorded .
18
176,143
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25817373
1conclusions
Our findings show that the high-dose vaccine is safe and robustly immunogenic .
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25817373
1conclusions
One shot of the high-dose vaccine could mount glycoprotein-specific humoral and T-cell response against Ebola virus in @ days .
20
176,145
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25061700
3objective
To evaluate the thermal antinociceptive effects and duration of action of buprenorphine hydrochloride after IM administration to American kestrels ( Falco sparverius ) .
0
176,146
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25061700
2methods
@ healthy @-year-old American kestrels .
1
176,147
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25061700
2methods
Buprenorphine hydrochloride ( @ , @ , and @ mg/kg ) and a control treatment ( saline -LSB- @ % NaCl -RSB- solution ) were administered IM in a randomized crossover experimental design .
2
176,148
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25061700
2methods
Foot withdrawal response to a thermal stimulus was determined @ hour before ( baseline ) and @ , @ , and @ hours after treatment administration .
3
176,149
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25061700
2methods
Agitation-sedation scores were determined @ to @ minutes before each thermal stimulus .
4
176,150
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25061700
2methods
Adverse effects were monitored for @ hours after treatment administration .
5
176,151
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25061700
4results
Buprenorphine hydrochloride at @ , @ , and @ mg/kg , IM , increased thermal threshold for @ hours , compared with the response for the control treatment .
6
176,152
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25061700
4results
There were no significant differences among buprenorphine treatments .
7
176,153
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25061700
4results
A mild sedative effect was detected at a dose of @ mg of buprenorphine/kg .
8
176,154
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25061700
1conclusions
At the doses tested , buprenorphine hydrochloride resulted in thermal antinociception in American kestrels for at least @ hours , which suggested that buprenorphine has analgesic effects in this species .
9
176,155
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25061700
1conclusions
Further studies with longer evaluation periods and additional forms of noxious stimuli , formulations , dosages , and routes of administration are needed to fully evaluate the analgesic effects of buprenorphine in American kestrels .
10
176,156
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24884455
0background
Patellofemoral pain syndrome ( PFPS ) is a common musculoskeletal condition , particularly among women .
0
176,157
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24884455
0background
Patients with PFPS usually experience weakness in the gluteal muscles , as well as pain and impaired motor control during activities of daily living .
1
176,158
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24884455
0background
Strengthening the hip muscles is an effective way of treating this disorder .
2
176,159
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24884455
0background
Neuromuscular training has also been identified as a therapeutic tool , although the benefits of this intervention in patients with PFPS patients remain inconclusive .
3
176,160
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24884455
2methods
This is a protocol of randomized controlled trial with a blind assessor .
4
176,161
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24884455
2methods
Thirty-four women with a clinical diagnosis of PFPS participated .
5
176,162
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24884455
2methods
These participants were allocated into two groups ( experimental and control ) .
6
176,163
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24884455
2methods
The experimental group performed twelve sessions to strengthen the knee extensors , hip abductor and lateral rotator muscles in association with neuromuscular training of the trunk and lower extremities .
7
176,164
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24884455
2methods
The control group performed the same number of sessions to strengthen the muscles of the hip and knee .
8
176,165
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24884455
2methods
The primary outcome was functional capacity ( Anterior Knee Pain Scale - AKPS ) at @weeks .
9
176,166
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24884455
2methods
Pain intensity , muscle strength and kinematic changes were also measured during the step down test after four weeks of intervention .
10
176,167
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24884455
2methods
Follow up assessments were conducted after three and six months to assess functional capacity and pain .
11
176,168
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24884455
2methods
The effects of the treatment ( i.e. between-group differences ) were calculated using mixed linear models .
12
176,169
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24884455
1conclusions
The present study was initiated on the @st of April @ and is currently in progress .
13
176,170
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24884455
1conclusions
The results of this study may introduce another effective technique of conservative treatment and could guide physical therapists in the clinical decision-making process for women with PFPS .
14
176,171
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24738317
3objective
The objective of this study was to evaluate the effect of nasal packing , septal suture technique and vacuum sealing drainage ( VSD ) after septoplasty .
0
176,172
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24738317
2methods
Ninety patients of nasal septal deviation in Combination with outfracture of the inferior turbinates who had received septoplasty were selected in this study .
1
176,173
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24738317
2methods
The patients were allocated into three groups , with thirty in each : for packing group , marcel materials were used for nasal packing after septoplasty ; for suturing group , septal suture technique was performed after septoplasty ; for VSD group , one drainage tube was used for negative pressure sucking after septoplasty without nasal packing .
2
176,174
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24738317
2methods
Postoperative signs and symptoms were compared between three groups .
3
176,175
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24738317
2methods
The comfort degree assessment included headache and nasal obstruction were evaluated by using visual analogue scale ( VAS ) at the @th hour and @ hour after operation .
4
176,176
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24738317
2methods
The edema in nasal cavity , hemorrhage .
5
176,177
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24738317
2methods
abscess , adhesive and healing rates after operation were compared among three groups .
6
176,178
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24738317
4results
The VAS score of headache and nasal obstruction and the severity of patient 's conditions were significantly less in septal suture group and VSD group than that in packing group at the @th and @th hour after operation .
7
176,179
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24738317
4results
The mucosa edema of nasal cavity was significantly slighter in septal suture group and VSD group than that in packing group at the third day after operation .
8
176,180
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24738317
4results
The healing rates and number of complications are better in septal suture group and VSD group than those in packing group at the @th day after operation .
9
176,181
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24738317
4results
There were no hemorrhage or abscess in VSD group .
10
176,182
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24738317
1conclusions
Septal suture technique and VSD after septoplasty can significantly relieve the distress of patients and reduce the healing time of mucosa in nasal cavity without increasing the risk of complications .
11
176,183
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25870079
3objective
To investigate baseline predictors of month @ best-corrected visual acuity ( BCVA ) and central foveal thickness ( CFT ) in patients with diabetic macular edema ( DME ) treated monthly with ranibizumab or sham .
0
176,184
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25870079
2methods
Post hoc analysis of DME patients in @ identical phase @ studies .
1
176,185
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25870079
2methods
Patients randomized to ranibizumab ( n = @ ) or sham ( n = @ ) .
2
176,186
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25870079
2methods
Multivariate regression on predictors with P < @ in univariate logistic regression using backward selection to retain predictors with P < @ .
3
176,187
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25870079
2methods
Patient characteristics correlating with month @ BCVA in Early Treatment Diabetic Retinopathy Study letter score @ ( @/@ ) or @ ( @/@ ) , gain or loss from baseline BCVA of @ , or CFT @ m.
4
176,188
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25870079
4results
Baseline predictors of BCVA @/@ in ranibizumab-treated patients were good BCVA , submacular fluid , no cardiovascular disease , no scatter photocoagulation , and male gender , whereas in sham-treated patients , they were mild increase in CFT , presence of hard exudates in center subfield , and absence of renal disease .
5
176,189
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25870079
4results
Predictors of improvement in BCVA letter score @ in ranibizumab-treated patients were poor BCVA , submacular fluid , young age , and short diabetes duration , and those in sham-treated patients were poor BCVA , young age , and mild increase in CFT .
6
176,190
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25870079
4results
Predictors of resolution of edema ( CFT @ m ) in ranibizumab-treated patients were mild foveal thickening and prominent subfoveal fluid , and those in sham-treated patients were poor BCVA , mild foveal thickening , and statin usage .
7
176,191
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25870079
4results
Month @ BCVA @/@ was predicted by poor baseline BCVA in ranibizumab-treated patients , and by poor baseline BCVA , large intraretinal cystoid spaces , renal disease , and absence of hypercholesterolemia in sham-treated patients .
8
176,192
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25870079
4results
Loss of BCVA @ letters was predicted in sham-treated patients by submacular fluid , intraretinal cystoid spaces , and renal disease .
9
176,193
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25870079
1conclusions
Patients with DME and submacular fluid , intraretinal cysts , severe thickening , or renal disease respond poorly when untreated and respond well to ranibizumab treatment .
10
176,194
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25870079
1conclusions
Elimination of submacular fluid , intraretinal cysts , and severe thickening are important goals of DME treatment , and in patients with renal disease , treatment should be very aggressive , with a goal of eliminating all macular fluid .
11
176,195
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24488743
3objective
This study included @-month-old children with a history of institutional care .
0
176,196
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24488743
3objective
Our goal was to : ( @ ) examine differences in indiscriminate social behaviors in children with a history of institutional care compared with home-reared children ; ( @ ) test whether foster care reduces indiscriminate social behaviors in a randomized controlled trial ; and ( @ ) examine early predictors of indiscriminate behaviors .
1
176,197
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24488743
2methods
Participants were @ children with a history of institutional care and @ never-institutionalized control ( NIG ) subjects enrolled in a randomized controlled trial of foster care for institutional care , assessed from toddlerhood to @ months .
2
176,198
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24488743
2methods
Indiscriminate social behaviors were measured naturalistically by using the Stranger at the Door procedure .
3
176,199
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