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Savor these next three games at Fenway Park—after those, you won't see The Carmine Hose back home until August 9th. Boston heads out after Wednesday's matinee on a ten-game West Coast swing that takes them to Anaheim (3), Seattle (4) and Chavez Ravine (3). To stay reasonably close to the Orioles, the Red Sox need to take at least six of the ten. Of the group, only the Dodgers are real contenders this year, but West Coast trips (particularly long ones) have historically been nightmares for Boston. When they return to Fenway, they will face the Aroldis Chapman-free Evil Ones and the D'Backs before heading out on another 10-game trip (Baltimore, Detroit, Tampa). The end of July and all of August will be a critical test of whether this team can do something special this year. Oh, and did we mention another West Coast trip in September (6 games)?

2019-04-25T00:44:07Z

http://www.fenwaynation.com/2016/07/after-tigers-red-sox-head-on-10-game.html

The Help Center on the Raw Shorts website is designed to provide a quick and easy self-service support option. You can search our knowledge base and community for a solution, or ask community members directly. If you can't find an answer, you can submit a request to an agent. How to access your video downloads? How do credits / exports work?

2019-04-25T06:10:52Z

https://rawshorts.zendesk.com/hc/en-us/articles/215266418-Help-I-have-a-question-and-I-need-an-answer

Fast, accurate, and confidential STD testing in Willingboro, New Jersey. Our STD Testing Willingboro service is designed to be fast and confidential. We have several locations across the metropolitan area for your convenience. When you choose Priority, you can have confidence in the test results you receive. Our tests are FDA approved to give you the most accurate results. Your STD tests are expedited and typically available in just 24-72 hours unlike the 1-2 week wait you might experience with a free STD testing clinic. If you need fast and confidential FDA approved STD testing in Willingboro, simply enter your zip code to find the nearest discreet and CLIA certified collection facility, order online or by phone, and get same day STD testing. Results are made available through a secure login online, or by phone with one of our care counselors. Why Choose Priority STD Testing Willingboro? Your time is important, which is why we offer same day STD testing in Willingboro. No appointments are required after your test has been ordered, and the testing process itself takes just minutes. Unlike other testing services, we will never fax or mail your lab order to the collection facility. This means you can get tested immediately after your order has been placed, knowing that your information is kept secure and encrypted. We understand the need for privacy when it comes to confidential STD testing in Willingboro. Our service is HIPAA compliant, and absolutely nothing will be mailed to your home or reported to your healthcare provider. We will never contact you directly without prior consent, and your privacy is respected every step of the way. Our business name or anything related to STD Testing will not appear on your bank or credit billing statements after your test has been ordered. Public clinics or health departments offering free STD testing in Willingboro provide little privacy when it comes to your sexual health. Going to your physician can be embarrassing and even raise questions as to the reason for your visit by others. Our private collection facilities are non-descript, meaning you will never be singled out for getting an STD test. No other patients will know the reason for your visit other than to provide a routine blood and urine sample. We aim to provide the fastest and most accurate STD test results in Willingboro to our patients. All of our tests are FDA approved and performed in CLIA certified laboratories so you can rest easy knowing your results are conclusive. Once your sample has been collected, results are expedited as a rush order and typically process in just 24-72 hours. You can access your results online 24 hours a day or by calling one of our care counselors. Unlike other testing services, we offer STD treatment in Willingboro to patients who test positive for Chlamydia, Gonorrhea, or Trichomoniasis. If you receive a positive result, simply call to speak with a care counselor who will assist in scheduling a phone consult with one of our physicians. No office visits are required, and your medication is sent directly to the pharmacy of your choice. In almost all cases, medication is available the same day.

2019-04-18T12:56:03Z

https://www.prioritystdtesting.com/locations/new-jersey/willingboro/220-sunset-rd-5d/

2019 Haynesville (La.) defensive tackle #73 Joe Evans playoff game highlights vs. Kentwood. Haynesville Louisiana "Gateway to North Louisiana" Haynesville was established in 1843; oil, cotton, and timber figured in its growth. Located in Claiborne Parish, warm hospitality and neighborly disposition are the heart of this community. Haynesville is a town in northern Claiborne Parish, Louisiana, United States, located just south of the Arkansas border. The population was 2,327 at the 2010 census. Haynesville is known as the "Gateway to North Louisiana" and the "Butterfly Capital of Louisiana". Haynesville is a town in northern Claiborne Parish, Louisiana, United States, located just south of the Arkansas border. The population was 2,679 at the 2000 census. Haynesville is known as the "Gateway to North Louisiana" and the "Butterfly Capital of Louisiana".

2019-04-19T03:03:45Z

https://todocamarasreflex.com/online-payday-loans-haynesville-la/

remake of "The abbey of crime" Having reached the end of my sinners life, waiting to be lost in the bottomless pit of the silent deserted divinity; in this cell of the beloved monastery of Melk, confined now with my heavy, ailing body, I prepare to leave on this parchment my testimony as to the wondrous and terrible events that I happened to observe in my youth. The Lord grants me the grace of giving faithful testimony of the events that took place in an abbey which name I prefer to cover with a pious mantle of silence; It was by the end of 1327, when my father decided that I accompany William of Occam, wise Franciscan monk who was about to initiate a mission which would take us to many famous cities and ancient abbeys. This way I converted at the same time in his amanuensis and disciple; and I did not have to repent, because with him I was witness of events worth being registered to leave to those who will come. This way, while days were passing by and I was knowing my master better, we reached the mount where the abbey was built up.

2019-04-18T13:23:16Z

http://www.abadiadelcrimenextensum.com/en/main-2/

Selling a stock front bowtie with black defenderworx inset installed and stock front and rear rs emblems. Just have to put new double sided tape on the rear. The front comes with the bracket which just clips to the grille. 50.00 shipped for everything. I am located in central nj. Last edited by Philevon; 07-15-2012 at 06:57 PM.

2019-04-19T08:47:23Z

https://www.camaro5.com/forums/showthread.php?t=237510

For the purposes of the present Agreement the Site is understood to be an Internet resource consisting of the totality of a collection of computer programs and information stored on computer. The Site is stored on an information system permitting access to the aforementioned information via the Internet at the address (domain name) http://dukalis.ru/, including all levels of the aforementioned domain, both those that are functioning on the date of the User's registration and any that may be created and brought into use at any time during the operational life of the domain. Access to the Site is possible both through a browser under a personal computer operating system and also by means of apps for mobile devices and apps for social networks. 1.3. The Agreement may be changed unilaterally by the Administration without any special notification to the User. The new edition of the Agreement comes into force from the moment it is posted to the Site. The current edition of the Agreement will always be kept on the Site at http://dukalis.ru/a-conditions/. 2.2. To begin using the Site, the User must go through the Site's registration process. To register, the User must fill out the registration form posted at http://dukalis.ru/a-register/ (hereinafter "the Form"). During the registration process, the User undertakes to provide the Administration with full, accurate, and up-to-date personal information in response to all the questions included in the Form. 3.7. Any requests, questions, complaints, or suggestions related to the functioning of the Site and/or the actions of the Administration may be addressed by the User to the Administration by using the contact details provided at http://dukalis.ru/a-showpage/name-contacts/ or else the postal address of LLC Loveplanet as given in point 1.2 of the Agreement. 5.4. By registering for the Site, the User grants Management permission to process his personal data by the means and for the purposes defined in the present Agreement and also in the Policy on Meeting the Requirements of Personal Data Protection located on the Site at: http://dukalis.ru/personal_data/. 5.6. The User permits the Administration to use the email and telephone number given by the User during registration in order to send advertising messages, information about events and new options on the Site, and also analogous information relating to other sites (at the Administration's discretion) and other information. The User may withdraw this permission at any time by using a special Site setting (http://dukalis.ru/a-account/) or by sending a request to the support service by means of filling out the form at http://dukalis.ru/a-support_search/a-trackernew/. 5.7. The User permits the Administration to connect free Services to his personal page without further notification. To disconnect a free Service, the User must send a request to the support service by filling out the form at http://dukalis.ru/a-support_search/a-trackernew/ or by using a special Site function for disconnecting the given Service. If the User does not agree with the terms included in the present point, he undertakes to inform the Administration by using the feedback form on the Site at http://dukalis.ru/a-support_search/a-trackernew/. 7.2. The conventional accounting currency for paying for paid Services on the Site is the Credit. The rules for acquiring Units, the payment terms, and information about the Credit's value are posted on the Site at http://dukalis.ru/a-purse/, accessible to registered users. 7.8. In order to confirm the reliability of his personal page the User may obtain Live status, which will permit him to access additional functionality of the Site. Live status may be obtained in the following ways: the User should visit the page on the Site at http://dukalis.ru/a-livestatus/ and give a current mobile telephone number. A unique code will be sent to that mobile number, and the User must enter that code into a special field on the Site. Live status is also awarded automatically to the User when he pays for any paid service on the Site.

2019-04-19T18:58:06Z

http://dukalis.ru/a-conditions

NO access information is stored when visiting this website. Therfore, NO access information is anlyzed. And, NO passing on of personal data to third parties takes place. This web page was constructed with the utmost care. However, no guarantee for the provided information is given. This website contains links to other third party websites. Their operators are exclusively responsible for the content of those third party websites. Applied protected company names, brands and trademarks are mentioned on this website. These belong to their respective owners. The appropriate German laws are respected. iocon and the logo are registered trademarks in Germany.

2019-04-20T19:21:02Z

http://www.iocon.de/index.php?c=impressum_e

The original MIDI 1.0 Specification called for using a 5-Pin DIN cable to connect MIDI compatible devices, but today there are many different "transports" capable of carrying MIDI data, and the specification for 5-Pin DIN has been updated. Some of the transport specifications for MIDI were developed in conjunction with other organizations (typically those who control the specification for that particular transport). Below are descriptions of all MMA-approved alternate transport specifications and where to get the document. This specification defines a method for encoding and decoding MIDI data for transmission over Bluetooth Low Energy (BLE) connections which enables product compatibility across all computing platforms (iOS, MacOS, Windows, and Android). The MIDI 1.0 Specification includes an Electrical Specification which uses a 5-Pin DIN connector. The Specification was updated in 2014 to reflect current design requirements such as 3.3 Volt circuitry and reduced RF interference. The "MIDI Media Adaptation Layer for IEEE-1394" (aka 1394-MIDI or Firewire-MIDI) is part of the AM824 Protocol developed in conjunction with the 1394 Trade Association in 1999 (now known as IEC International Standard 61883, Part 6).

2019-04-21T06:53:01Z

https://www.midi.org/specifications-old/category/transport-specifications-and-info

Federally incarcerated persons can be placed in disciplinary segregation as punishment for committing institutional offences. Prisoners subject to disciplinary segregation are entitled to certain protections, such as limits on the number of days they can stay in solitary; an independently adjudicated hearing concerning their placement; access to a lawyer for that hearing; and the benefit of a high criminal law standard of proof (proof beyond a reasonable doubt). In contrast, under the regime challenged in this case, federally incarcerated persons can be placed in administrative segregation for a variety of vague and general reasons, such as belief on the part of prison administrators that the prisoner threatens the safety of the prison or anyone in the prison. Under administrative segregation, inmates can be put in solitary indefinitely, do not benefit from review of their placement by an independent decision-maker, and do not have access to legal counsel at any administrative review of their placement. Prisoners in solitary confinement are confined in prison cells and deprived of meaningful human contact for up to 23 hours a day, sometimes for months and years at a time. Prolonged, indefinite placement in solitary confinement has been recognized as causing serious harms including psychosis, major depression, hallucination, paranoia, self-harm, and suicidal behaviour. Placement in solitary confinement is known to exacerbate existing mental health conditions and the impacts of past trauma. Federally incarcerated women experience specific and severe harms as a result of solitary confinement. Women are at greater risk of self-harming behaviours that may be used to justify their initial placement in solitary confinement and that are likely to worsen while in solitary. Women are also disproportionately impacted by physical and psychological trauma arising from pre-prison incidents of violence. Indigenous women are the fastest growing segment of the prison population in Canada and are disproportionately represented both among women in prison and among women in solitary confinement. The plaintiffs in this case are challenging prolonged, indefinite solitary confinement under the Charter. Among other things, they argue that this practice constitutes cruel and unusual punishment, violates the life, liberty and security of the person, and discriminates against mentally ill and Indigenous persons. West Coast LEAF intervened in this case at the BC Supreme Court to present an intersectional lens on the constitutionality of solitary confinement that attends to overlapping inequalities. We argued that in order to truly understand the stigmatization and harms caused by solitary, the court should consider how this practice may be experienced differently by women, particularly Indigenous women and/or women with mental illness. The BC Supreme Court released its judgment on January 17, 2018. Justice Peter Leask ruled that solitary confinement violates sections 7 and 15 of the Charter, by harming prisoners’ life, liberty, and security of the person and by discriminating against Indigenous prisoners and prisoners experiencing mental illness. We are pleased to see the disproportionate and discriminatory harms of solitary confinement recognized by the court. The judgment accepts the evidence of experts and others who testified about the ways in which solitary confinement triggers and exacerbates mental health conditions, and increases risks of self-harm and suicide. The court also recognized that these harms are more severe for Indigenous women. The court found that solitary confinement harms all prisoners, and that the effects are discriminatory against Indigenous persons and persons experiencing mental illness generally. The court struck down the solitary confinement regime (described in the law as “administrative segregation”), giving the government one year to change the law. A bill was introduced in Parliament on June 19, 2017 that proposes to add some procedural safeguards for prisoners subjected to solitary confinement. However, this bill does not address the real harms associated with isolation or their disproportionate impacts for Indigenous people and people experiencing mental illness. Isolated confinement – by any name – has no place in Canada. Canada appealed the BC Supreme Court’s decision on February 16, 2018. West Coast LEAF was granted leave to intervene in the appeal jointly with the Native Women’s Association of Canada (NWAC) on June 29, 2018. The appeal was heard by the BC Court of Appeal on November 13 and 14, 2018. West Coast LEAF and NWAC provided written submissions and attended the hearing. Under the BC Supreme Court decision, Canada had until January 17, 2019 to replace the current law authorizing solitary confinement. On October 16, 2018, the federal government introduced Bill C-83 to amend the current administrative segregation regime. As of January 7, 2019, Bill C-83 has passed first and second reading in the House of Commons and the Standing Committee on Public Safety and National Security has recommended amendments to the bill. Before becoming law, the bill must pass its third reading and go through the Senate. At the BC Court of Appeal hearing in November, Canada asked the court to give the government an extra six months to change the law. On January 7, 2019, the BC Court of Appeal released its decision on this issue, allowing for the current law to continue until June 17, 2019 with conditions in order to give the government more time to pass its new legislation while trying to mitigate some of the Charter violations of the current law. The BC Court of Appeal has not yet released its decision on Canada’s appeal of the BC Supreme Court decision. July 2018 news alert: Solitary appeal moving forward – and we’ll be there!

2019-04-19T03:35:34Z

http://www.westcoastleaf.org/our-work/bccla-jhsc-v-canada-2016/

MSRPReg: $19.99 Save $6.40 (32% off) Switchel Palm Sugar What are the health benefits of Tulsi Green Tea? Boost Your Bust Review Now, that’s the theory. In real life, most people get about 40% of their calories from fat! On a typical 2,000 calories menu, this is 800 calories. We don’t realize this because fatty foods are everywhere. 11. You may feel some dizziness during showering, so prepare a bottle of water next to you to drink. Black or green, hot or iced, tea is gaining in popularity. Many cities and shopping malls feature specialty tea shops, and bottled teas vie for space on store shelves. The tea market continues to grow year after year. Facebook Like The Positive Reviews © 2017 CureJoy Inc. All Rights Reserved Quickorder 6. ↑ Chacko, Sabu M., Priya T. Thambi, Ramadasan Kuttan, and Ikuo Nishigaki. “Beneficial effects of green tea: a literature review.” Chinese medicine 5, no. 1 (2010): 1. Groups Home Improvement New! Comments: Like This Story? Leave A Comment! Limited Edition Flavors I’m a Naturopath and a best-selling Amazon author who has helped over 14,793 women and men reclaim their health, fitness, and happiness with the advice they needed to improve their physical well-being. Anti-Estrogen Take a breath and then put your left foot and then your right foot up to your hands, then your legs, bend forward a little, put your head on your knees, and let out a horn. Two To Three Cups A Day Is The Limit Collagen is a protein in our skin that help us for looking young, the antioxidants present in green tea could possibly support hinder free radicals from breaking down collagen. Moroccan Mint Herbal Products View my Subscription(s) 90 Decaffeinated The free radicals created in the body are responsible for corroding the body in various ways, one of which we see as the signs of aging and its related symptoms. Antioxidant-rich green tea neutralizes the oxidants or free radicals present in the body. The catechin polyphenols present in it are hugely responsible for its antioxidizing effects, the most powerful among them being the epigallocatechin gallate. Therefore, regular consumption of green tea can effectively delay the signs and symptoms of aging. If you have ever had kidney stones, you know how painful they can be. What other items do customers buy after viewing this item? I should know. How To Remove Eye Bags & Lip Lines Fast (Watch) Now are you beginning to see just how powerful Renu Herbs Organic Tea Leaves is? GMOS or Genetically modified foods Mar 12, 2018 #6 Pros Of The Red Tea Detox: Green tea may be the perfect addition to your diet if you are suffering from diabetes (3). The Language of Desire Review Prepaid Cards Auto April 2018 Bollywood Movies Glycemic Index Servings Per Container: Green tea has long been acknowledged for its health and wellness benefits, including weight loss assistance. The evidence is irrefutable. But are we overlooking something better? TAKE YOUR HEALTH TO THE NEXT LEVEL Referral Program Shincha is often the first tea of the season to be picked. This green tea is refreshing and full bodied in flavor and contains low amounts of caffeine. Red Tea Detox vs other detox plans back Mugs and Accessories The Yoga Booty Challenge is for ladies between the ages of 18-65 including total novices to wellness, working out and yoga. The Yoga Burn Booty Challenge test can be similarly as successful for ladies that have been into wellness and yoga their while lives. Organic Herbal Infusions HelloFresh Review: Can These Family-Friendly Recipes Simplify Meal Planning? Email me when it’s back in stock Add to Cart Add to Wishlist Interest-Based Ads The 4th benefit of green is about cholesterol, It helps with cholesterol levels. People with high total cholesterol have somewhere around two times the possibility for heart diseases in comparison with people with ideal levels, CDC suggests.

2019-04-19T22:20:40Z

http://redteadetoxmix.com/rooibos-tea-for-sale-rooibos-tea-wiki/

Follow Friday? If you are on Instagram, so are we! I love RIT because of the uniqueness of our community. Students are free to express themselves and explore their academic interests. Professors here share their research and passion for what they do. Staff members are welcoming and love to help students. It is simply a great place to be! This is why I chose to complete both my bachelor and master degree at RIT. Growing up in a biracial family, and nowhere near my native community, I was left with many questions about my identity and my culture’s history. The Future Stewards Program (FSP) has provided me with support on campus and assisted with my cultural search in understanding who I am. The Future Stewards Program has played a huge role in my career at RIT. I became dedicated to attending RIT while taking part in a Future Steward's sponsored campus visit the Summer before my junior year of high school. I along with other students from Salamanca, NY, located on the Allegany Indian Reservation of the Seneca Nation of Indians, were hosted by Future Steward's staff and introduced to the support services offered and the educational programs offered at RIT. The Future Stewards Program here at RIT has been the most shaping factor in my career and personal development. My family's tribe is halfway across the country from where I grew up, since my grandmother was encouraged by her mother to leave the reservation to find success elsewhere. My first year at RIT, though very fulfilling, felt deprived of other people like me. I wanted to become a part of a community on campus that could foster my growth as a Native American student in STEM.

2019-04-21T00:28:14Z

https://www.rit.edu/diversity/futurestewards/

On Tuesday 30 October, the Club hosted a series of Motoring Lectures at Pall Mall, bringing together some of the finest experts in the field of motoring and motorsport. The lectures, which took place during the London Motor Week celebrations, were open to both members and non-members, and provided access to some of the biggest names in the industry. Headlining the event was three-time Le Mans 24 Hours winner and current Formula E Team Principal, Allan McNish. McNish provided a fascinating insight into the technologies currently being developed and used in Formula E, and said “From petrol to diesel, diesel to hybrid to fully battery electric cars in just eleven years, a rate of change that I never thought I’d see in my lifetime – it’s a new exciting era”. McNish delivered an interesting presentation, from Audi’s move from Le Mans to the Formula E Championship – the first fully electric racing series in the world, which takes place on street tracks specifically designed for the championship in major cities such as Hong Kong, Paris, Berlin and New York. McNish enthusiastically championed the race series, and how the technical development is actively being adapted to benefit the future of the mass production road car. He said “There are more manufacturers competing in Formula E than any other racing championship in the world. The technical development in the Audi e-tron provides increased range, lightweight construction, efficiency and performance which is filtering down to the road car. By 2025 Audi will have twelve fully battery road cars and 33% of all Audis will be electric”. Other guest speakers included Bob Owen; Head of Legislation for the Federation of British Historic Vehicle Club, who explored the changing legislation relating to classic cars and its future effects, while acclaimed author and tractor expert, Stuart Gibbard, revealed the symbiotic relationship between Aston Martin cars and David Brown tractors in his lecture. Gibbard revealed the fascinating relationship between English industrialist David Brown, the owner of David Brown tractors, and the luxury sports car manufacturer Aston Martin – the legacy of which is still so prevalent today in its latest models. Finally, Mike Bishop, Land Rover specialist at Jaguar Classic, spoke about the rich history of the Land Rover going right back to the very first Series 1.

2019-04-21T11:04:34Z

https://www.royalautomobileclub.co.uk/news/from-combustion-to-electric

Our Athena has been named the "Love Sponge" and gives as much love as she soaks up. Our little girl is turning ONE on the 27th! She has been with us for 9 months now and we are so happy she is part of our family. You have bred an exceptional kitten. We are so pleased that we chose your cattery. You have been helpful and kind. It has been a comfort to us to know that you are a concerned and caring breeder long after your kitten became ours.. Athena likes to help with wrapping the Christmas presents! I can't imagine our lives without Chloe. She is so loving and intelligent, which is a great combination! She is playful and communicative, always getting her point across. We figured if we were going to have a cat, then let's adopt the best....and she is. Thank you for the gift of Chloe. "I thought you would like to see a picture of the kittens we got from you at the end of last summer now that they are almost a year old. They have turned out to be exceptional pets. Besides being gorgeous, they are affectionate and smart, each with his own personality. Cricket is outgoing and talkative and Kismet is a little shy and very, very sweet. They love people and are always at the door to welcome us when we come home. We have owned Siamese cats for 30 years and couldn't be any happier with these guys (which is why we just got our third boy from you a few weeks ago). As you can see from the second picture, he is fitting right in! He came in like he owned the place and it only took a few days for the older ones to adjust to a new addition. I would recommend Mi Cattery to anyone who is looking for a wonderful cat." This is my kitten "Poochie" (I know it's a dog name, but he acts just like a little puppy)! He is beautiful and seems to be happy. He is lovable, affectionate and very personable. the first night I had him, I expected that he would cry all night, but not at all. He just rolled up on me and slept through the night. I went from thinking all my life that cats were unpersonable animals to finding out that Siamese cats are wonderful!!!! Thank you Honey for this great pet! We are absolutely delighted to have Romeo as part of our family. He is very affectionate and has become devoted to us in the relatively short time that he has been with us. He loves to play, is quite spirited, highly intelligent and very friendly to all who meet him. Everything you told us about the kittens you raise is right on the money. But it feels like he's been in our family forever. He's so sweet and greets us at the door when we come home. His favorite game is laser tag. Sam purrs up a storm and wins over everyone who comes to visit...Even the self-proclaimed "dog people." As you can see from the pictures, he really enjoys our screened-in porch. Sandy has grown a lot since March. She's great. She loves to be around us all the time, following us everywhere. She also loves when we have guests over. She throws herself in front of the doorway when it is time for them to leave, as if she is telling them not to go. My beautiful Sapphire now one year old. She is quite beautiful . She has filled out and has a beautiful coat. Sapphire is the best cat I have ever had because she's got so much personality and is so playful and loving. Love her to pieces! She is a loving, playful and very affectionate kitty. It's "play with me and pet me " all the time”. She comes on my lap and rubs and purrs. We are devoted to each other. She is smart, affectionate, a great companion and playful. Sapphire is badly spoiled. She is the love of my life. Thanks a million. You are a great breeder and if you need a testimonial at any time, count on me. My name is Jeff and I purchased 2 chocolate point Siamese kittens from you in February The kittens are wonderful. and I absolutely adore them. The boy on the right of the picture is Teeko and the girl is Meesha. These cat's are the most loveable, affectionate and intelligent cat's I've ever had. They follow me down the stairs in the morning when I leave and when I come home they are waiting by the door. They are always talking to me and they demand attention. They are everything that a person could possibly want in a pet.

2019-04-25T16:23:02Z

http://micattery.com/Center_Ref/CR97.htm

Portugal dropped the first points at the 2014 World Cup qualifying group stage, after losing against Russia in Moscow, by 1-0. Cristiano Ronaldo started the game on the line-up despite having picked up a small injury last week against Barcelona, but was unable to lead the Portuguese National Team to a good result in Russian lands. Russia hosted Portugal at the Luzhniki Stadium in Moscow this Friday afternoon and an early goal from Kerzhakov at the 6th minute of the 1st half, turned out to be enough to defeat the Portuguese side by 1-0. Paulo Bento's men dominated most of the game but slammed against a well prepared Russian defensive wall, which shouldn't be a surprise to anyone if we have in mind that it is Fabio Capello who is pulling the strings on this Russian National Team. Cristiano Ronaldo played the full 90 minutes, but just like the rest of his teammates, he struggled to find spaces and very rarely managed to be close to score. With this victory, Russia now leads Group F with 9 points and leaves Portugal behind with 6, as we now complete the 3rd matchday of this qualification stage, for Brazil's 2014 World Cup. The 2014 World Cup qualification group stage includes a 10-game package for each team competing and a victory at Moscow this Friday would have surely been a golden step towards Portugal's main objective of assuring their presence in Brazil, in roughly 2 years from now. However, Cristiano Ronaldo and his teammates didn't succeed in coming off from Russia with any point on the bag and will now delay any decisive match for later stages in 2013 and possibly 2014. Fabio Capello did warn this past Thursday that his side was going to follow a strict gameplan that would increase their chances of beating Portugal. The Italian manager wasn't bluffing and we all witnessed a Russian side incorporating a classic "catenaccio" playing style. Russia blocks and lines were always very tight and near each oher, while at the same time, the counter-attacks strategy ended paying off very early in the game, after an error was made by the Portuguese midfield and defense players. From that moment onwards, Capello knew he wouldn't have to bother in risking much more than what he already had in mind in the beginning of the game. It took no more than 6 minutes for Russia to take the lead and put Portugal in trouble. Paulo Bento's men were trying to initiate a play right from their defensive line, but felt the Russian players pressing hard, which ended up forcing a mistake. SC Braga's midfielder, Rúben Micael, failed to connect his pass in a dangerous area and allowed Shirokov to immediatly assist Kerzhakov for a 1-on-1 situation against Rui Patrício. The Zenit St Petersburg's forward didn't miss his chance and put the Russian side one goal up. There was plenty of time left to be played, but with an Italian manager on the bench, a team on the lead very rarely expose themselves to dangerous situations. Russia granted the game's control to Portugal, who clearly dominated the ball possession until the end of the clash. However, the lack of spaces and the bad pitch conditions were basically two huge obstacles that the Portuguese players proved not to be able to deal with. Despite the dominance, Russia resisted to all the Portuguese attempts of getting an equalizer and limited themselves to launch a few counter-attacks every now and then. The result wouldn't suffer any further change and Russia pulled off what can turn out to be a highly valuable victory and 3 points. With 7 matches left to be played for each team, Russia counts with a perfect start (3 games and 3 wins), while Portugal will have to get back to the winning track next Tuesday, as they will be hosting Northern Ireland for the 2014 World Cup Group F, Gameday 4. Cristiano Ronaldo's next game will be for Portugal and against Northern Ireland, for the World Cup 2014 qualification stage, next Tuesday (16-10-2012). You can watch Juventus live stream, Portugal vs Northern Ireland, Spain vs France, Poland vs England and Germany vs Sweden, all matches provided from our football live streams section.

2019-04-20T13:06:21Z

https://www.ronaldo7.net/news/2012/570-russia-1-0-portugal-harsh-loss-in-moscow-holds-portuguese-ambition.html

squares. Cut carrots on diagonal into thin slices. pieces. Combine soy sauce and brown sugar. broccoli, cauliflower, and 1 1/2 cups of the broth. peanuts and scallions sprinkled on top.

2019-04-20T20:23:39Z

http://www.recipesource.com/soups/stews/02/rec0263.html

Argentine hemorrhagic fever (AHF) is an endemo-epidemic disease caused by Junín virus (JUNV), a member of the arenaviridae family. Although a recently introduced live attenuated vaccine has proven to be effective, AHF remains a potentially lethal infection. Like in other viral hemorrhagic fevers (VHF), AHF patients present with fever and hemorrhagic complications. Although the causes of the bleeding are poorly understood, impaired hemostasis, endothelial cell dysfunction and low platelet counts have been described. Thrombocytopenia is a common feature in VHF syndromes, and it is a major sign for its diagnosis. However, the underlying pathogenic mechanism has not yet been elucidated. We hypothesized that thrombocytopenia results from a viral-triggered alteration of the megakaryo/thrombopoiesis process. Therefore, we evaluated the impact of JUNV on megakaryopoiesis using an in vitro model of human CD34+ cells stimulated with thrombopoietin. Our results showed that CD34+ cells are infected with JUNV in a restricted fashion. Infection was transferrin receptor 1 (TfR1)-dependent and the surface expression of TfR1 was higher in infected cultures, suggesting a novel arenaviral dissemination strategy in hematopoietic progenitor cells. Although proliferation, survival, and commitment in JUNV-infected cultures were normal, viral infection impaired thrombopoiesis by decreasing in vitro proplatelet formation, platelet release, and P-selectin externalization via a bystander effect. The decrease in platelet release was also TfR1-dependent, mimicked by poly(I:C), and type I interferon (IFN α/β) was implicated as a key paracrine mediator. Among the relevant molecules studied, only the transcription factor NF-E2 showed a moderate decrease in expression in megakaryocytes from either infected cultures or after type I IFN treatment. Moreover, type I IFN-treated megakaryocytes presented ultrastructural abnormalities resembling the reported thrombocytopenic NF-E2−/− mouse phenotype. Our study introduces a potential mechanism for thrombocytopenia in VHF and other diseases associated with increased bone marrow type I IFN levels. Viral hemorrhagic fever (VHF) is an acute systemic febrile syndrome caused by a diverse group of RNA viruses from the Arenaviridae, Bunyaviridae, Filoviridae, and Flaviviridae viral families –. Patients with this syndrome present with a combination of fever, prostration, malaise, and differing degrees of hematological complications , . When severe, patients with VHF can present with generalized bleeding that results from alterations of the vascular endothelium, blood coagulation components and platelet levels –. Moreover, a plasma platelet aggregation inhibitor has been described in patients with different types of VHF , . These findings suggest that different etiologic agents of VHF may share common processes for disturbing hemostasis during infection, leading to a systemic and frequently fatal disease. In fact, thrombocytopenia is one of the most consistent findings among human patients and experimental animal models of VHF, and it is used as a major diagnostic feature in patients with VHF , . However, the causes of the thrombocytopenia associated with VHF remain poorly understood. In this connection, disseminated intravascular coagulation (DIC) could explain platelet consumption; nevertheless, the occurrence of DIC in VHF infections is inconclusive, at least for the arenavirus family . Therefore, a high level of splenic sequestration or impaired megakaryo/thrombopoiesis could be the major physiopathogenic mechanisms responsible for the low platelet count. We hypothesized that the thrombocytopenia observed in VHF is the result of a viral-triggered alteration of the megakaryo/thrombopoiesis process. Support for this hypothesis comes from studies of experimental murine lymphocytic choriomeningitis virus (LCMV) infection showing an association between thrombocytopenia and reduced megakaryocyte number at the bone marrow level and the observation that the reversible depression of hematopoiesis during early LCMV infection is a direct effect of IFN α/β . In addition, megakaryocyte alterations were found in patients with Argentine hemorrhagic fever (AHF) and Dengue , and in experimental studies involving Junín virus (JUNV) infection of guinea pigs and the primates Callithrix jacchus and Rhesus macaques . AHF is an endemo-epidemic disease caused by JUNV, a member of the Arenaviridae family. Although a recently introduced live attenuated vaccine has proven to be effective, AHF remains a potentially lethal infection and JUNV is considered to be a potential biological weapon . Relative to other etiologic agents of VHF, JUNV is a suitable model for studying VHF pathogenesis due to the availability of a relatively large amount of data from both human and experimental infections, viral strains with known nucleotide sequences, several monoclonal antibodies against various components of the virus and an effective protective vaccine –. In this study, we evaluated whether the different megakaryopoiesi/thrombopoiesis stages (including proliferation, commitment, maturation, proplatelet formation and platelet release and function) are affected by JUNV infection of hematopoietic progenitor cells. Our results showed that human CD34+ cells are infected by JUNV. Furthermore, we have identified selective inhibition of platelet release involving transferrin receptor 1 (TfR1) and type I IFN (IFN α/β) as paracrine mediators. To analyze whether the thrombocytopenia observed in AHF patients could be the result of altered megakaryopoiesis, we used an in vitro model of human CD34+ cells stimulated with thrombopoietin (TPO). Under our culture conditions, TPO stimulation promoted proliferation, an increase in cell size and CD41 expression and a decrease in CD34 expression (Figure 1A–C). The formation of long, branching processes called proplatelets, which showed small platelet-sized swellings that represented the developing platelets , was also observed on days 11–12 of culture (Figure 1E). In agreement with previous reports, platelets were released into the culture medium . The kinetics of in vitro platelet release started at days 11–13, peaked at day 17 and declined after 21 days, correlating with the apoptosis/senescence of the cell culture (Figure 1D). Fig. 1. Characterization of liquid cultures of human CD34+ cells stimulated by TPO. CD34+ cells (1×104/ml) purified by immunomagnetic positive selection were cultured in IMDM containing 5% human serum and TPO (25 ng/ml added at days one and seven of the cell culture). At the indicated culture times, (A) total cell count was determined with a hemocytometer and (B) cell size was analyzed by flow cytometry. (C) CD41 and CD34 expression were evaluated by labeling cells with specific mAbs or corresponding matched isotypes and establishing the percentage of positive cells by flow cytometry analysis. (D) Platelet (Plt) count was evaluated by flow cytometry and cellular apoptosis was determined by detecting nuclear morphological changes of cells stained with acridine orange and ethidium bromide by fluorescence microscopy. (E) Culture morphology was assessed by phase contrast microscopy [original magnification 450×, except day 12 inset (1200×)]. The values expressed in panels A–D represent the mean ± SEM of five independent experiments. Panel E shows a representative experiment of five similar replicates. Figure 2 shows that JUNV infection of CD34+ cells influenced neither their apoptosis, their proliferation rate, their maturation (CD42b+ and ploidy levels), megakaryocyte differentiation (CD41+) nor the clonogenic ability of megakaryocyte progenitors. Surprisingly, JUNV infection induced a significant decrease in both proplatelet formation (Figure 3A and B) and platelet release (Figure 3C and D) when compared to mock- or UV-irradiated JUNV-infected cultures. These results indicate that viral infection selectively hindered two key steps in thrombopoiesis that represent the last stage of the megakaryocyte lifespan, and viral replication was necessary to observe this effect. Fig. 2. Influence of JUNV infection on cellular apoptosis, proliferation, clonogenic capacity and megakaryocyte development of TPO-stimulated CD34+ cells. CD34+ cells were infected with JUNV at a MOI of one or the equivalent volume of UV-irradiated virus or Vero cell supernatant (mock) for one hr at 37°C, washed, and then stimulated with TPO. (A) Apoptosis, (B) total cell count, (C) megakaryocyte colonies grown in collagen-based serum-free medium containing 50 ng/ml TPO, percentages of (D) CD41+ and (E) CD42b+ cells and (F) ploidy distribution were determined at the indicated days of culture, except for colonies and ploidy, which were counted after 12 or 14 days of culture, respectively. The values represent the mean ± SEM of four independent experiments. Fig. 3. JUNV infection impairs proplatelet production and platelet release. CD34+ cells were mock-infected or infected with UV-irradiated JUNV or JUNV and then stimulated with TPO. (A) The number of megakaryocytes displaying proplatelets was determined at day 12 of the culture by F-actin and nuclear staining with phalloidin-TRITC and DAPI, respectively, and examined by fluorescence microscopy. The values represent the mean ± SEM of four independent experiments. (B) A representative picture of a proplatelet-displaying megakaryocyte. (C) Plt count was determined by flow cytometry. At different days, culture aliquots were stained with an anti-CD41-FITC mAb and the acquisition rate was fixed at 1 µl/sec for 100 sec. Events were collected without gating using a log scale for size (FSC) and intracellular granularity (SSC). An analytical gate was determined based on the scatter properties of peripheral blood platelets treated similarly. Culture-derived platelets were counted as CD41+ events with the same scatter properties as blood platelets. The values are expressed as platelets (×105) and represent the mean ± SEM of six independent experiments. * indicates p<0.05 vs. UV-irradiated JUNV or mock. (D) A representative flow cytometric analysis 15 days after TPO stimulation. To gain a deeper insight into the platelet biology of JUNV-infected cultures, we next explored the ability of platelets to express P-selectin. Our flow cytometric analysis showed that 11.1±3.3% of resting platelets generated in UV-irradiated JUNV-infected cultures expressed P-selectin on their surface, and after thrombin stimulation this rose to 49.2±4.1% (n = 3, p<0.05). In contrast, P-selectin externalization was significantly reduced in platelets derived from JUNV-infected cultures (3.3±1.3% and 13.5±4.1% for resting and thrombin-stimulated samples, respectively, n = 3). As shown in Figure 4A, CD34+ cells were susceptible to JUNV infection. At ten days post-infection (p.i.), RNA from JUNV-inoculated CD34+ cells displayed a fragment of the viral genome, while RNA from cultures exposed to the UV-irradiated JUNV strain did not. Immunofluorescence and flow cytometric studies revealed that 4.1±0.2 and 4.9±0.5% of the cells were infected, respectively (Figure 4B and C). These results were in sharp contrast to the 68±11% of JUNV-positive cells observed after in-parallel infection of the susceptible Vero-76 cell line (Figure 4D). Although some megakaryocytes were clearly positive for JUNV, most of the susceptible cells were not (Figure 4B and C). These results suggest that viral infection per se is not a direct cause of the observed reduced thrombopoiesis. Fig. 4. JUNV replication in CD34+ cells. CD34+ cells were inoculated with UV-irradiated JUNV or JUNV and stimulated with TPO for ten days. Viral replication was assayed by RT-PCR, immunofluorescence and flow cytometry. (A) RT-PCR studies. (B) To detect JUNV antigens by immunofluorescence cells were washed, cytocentrifuged on silanized glasses, fixed, permeabilized and incubated first with a pool of specific mAbs against JUNV and a rabbit-anti-human vWF polyclonal Ab to identify megakaryocytes, and then with FITC-conjugated anti-rabbit (green) and Cy3-conjugated anti-mouse Igs (red). The slides were counterstained with DAPI and photographed at 1000× magnification. (C) Cells were stained as in B and then analyzed by flow cytometry. (D) As a positive control, JUNV-susceptible Vero-76 cells were inoculated with JUNV and seven days later were stained with the pool of specific mAbs against JUNV followed by Cy3-anti-mouse Igs. Negative controls in B and C were performed by incubating cells only with secondary Abs. Panels show a representative experiment of three similar replicates. In contrast to Lassa and other old world arenaviruses, which use α-dystroglycan to infect cells, it has been reported that TfR1 is the cellular receptor for several new world arenaviruses, including JUNV . Therefore, we evaluated the expression of this protein in JUNV-infected cultures. Interestingly, TfR1 expression was significantly higher in JUNV-infected CD34+ cells compared to UV-irradiated JUNV-infected cells, suggesting that JUNV infection promotes further infection (Figure 5A and B). Fig. 5. Role of TfR1 in JUNV infection and impaired platelet production. (A) The kinetics of TfR1 expression after JUNV infection in CD34+ cells stimulated with TPO were determined by flow cytometry. (B) Receptor expression was detected in UV-irradiated JUNV- and JUNV-infected cells incubated with FITC-anti-CD71 (anti-TfR1) mAb or with a matched isotype control. The histogram depicts a representative flow cytometric analysis of TfR1 staining after 120 hr of infection. (C) CD34+ cells were pre-incubated with an anti-CD71, anti-HLA-ABC mAb or ferric ammonium citrate (FAC, 10 µg/ml) for 1 hr (to down-regulate TfR1). Cells were then infected with JUNV and stimulated with TPO and viral antigens were detected by flow cytometry. The figure shows a representative experiment of three similar replicates. (D) CD34+ cells were treated as mentioned in C, and also with deferoxamine (1 µM) for 24 hr (to up-regulate TfR1). Platelets produced in culture were counted at day 15. The values represent the mean ± SEM of three independent experiments,* indicates p<0.05 vs. UV-irradiated JUNV, # indicates p<0.05 vs. JUNV. Having demonstrated that TfR1 was up-regulated by viral infection, we next examined whether TfR1 has a role in JUNV infection and in the inhibitory effect of JUNV on platelet release. When CD34+ cells were incubated with a specific monoclonal antibody (mAb) against TfR1, neither viral antigens nor the inhibitory effect of JUNV on the number of platelets generated were observed (Figure 5C and D). In contrast, incubation with anti-HLA-ABC (an irrelevant mAb) had no effect. Similar results were obtained when TfR1 was first down-regulated by iron overload. However, up-regulation of TfR1 levels by iron deprivation did not modify the effect of JUNV on platelet generation (Figure 5D). These results not only unveil a potential new mechanism by which JUNV spreads its infection in hematopoietic progenitor cells, but they also provide evidence that the reduced thrombopoiesis is specifically related to JUNV infection. Because the number of infected cells was low and only a few were positively identified as megakaryocytes, it was reasonable to consider that the decrease in platelet release was most likely the result of a bystander cell effect rather than a direct effect of JUNV on megakaryocytes. Thus, to further study the biological effects of viral infection on platelet release, we analyzed the effect of poly(I:C), which mimics the double-stranded RNA (dsRNA) product from the replicative cycle of most viruses . Figure 6A shows that the addition of poly(I:C) at early time points to TPO-stimulated CD34+ cell cultures significantly decreased platelet release. Similarly to JUNV infection, this inhibition was not related to apoptosis induction or a decrease in megakaryocyte generation (data not shown). These results suggest that the reduction in platelet release could be a more generalized effect and may not be restricted to JUNV infection. Fig. 6. The role of the IFN β pathway in platelet production and JUNV infection. (A) CD34+ cells were treated with poly(I:C) (100 µg/ml) at the indicated days, stimulated with TPO, and Plt counts were determined at day 15 of the culture. The values represent the mean ± SEM of four independent experiments, * p<0.05 vs. vehicle (control). (B) IFN β mRNA levels in UV-irradiated JUNV- or JUNV-infected CD34+ cells were determined by RT-PCR at the indicated days of culture. The figure shows a representative experiment of three similar replicates. (C) CD34+ cells were treated with IFN β and stimulated with TPO. Plt counts were determined at day 15 of the culture. The values represent the mean ± SEM of three independent experiments,* indicates p<0.05 vs. no IFN β, # indicates p<0.05 vs. IFN β (10 U/ml). (D) Total cell number was determined at the indicated days of culture by counting cells with a hemocytometer. Similar results were obtained in MTT assays. The values represent the mean ± SEM of three independent experiments. (E) Anti-IFN β (1,000 neutralizing units) or an equal volume of rabbit Igs was added before CD34+ cell infection and Plt counts were determined at day 15. Values represent the mean ± SEM of three independent experiments, * indicates p<0.05 vs. UV-irradiated JUNV. (F) Type I IFN receptor subunit (IFNAR1 and 2) mRNAs were evaluated by RT-PCR in megakaryocyte precursors purified by immunomagnetic positive selection (99±1% of purity). The figure shows a representative experiment of three similar replicates. (G) CD34+ cells were infected with JUNV and 1000 neutralizing units of anti-IFN β or an equal volume of rabbit Igs were added before TPO stimulation. Viral antigens were detected by flow cytometry. The figure shows a representative experiment of two similar replicates. (H) The kinetics of TfR1 expression in the presence or absence (vehicle) of IFN β (10 U/ml) in CD34+ cells stimulated with TPO were determined by flow cytometry. Because poly(I:C) is a potent inducer of IFN β release in vitro and in vivo , we next tested if this was a functional mechanism in our in vitro system. While UV-irradiated JUNV-infected-CD34+ cell cultures stimulated by TPO did not express IFN β mRNA, increasing expression over time was observed in JUNV-infected cultures (Figure 6B). Accordingly, 10 U/ml of IFN β efficiently inhibited platelet release (Figure 6C). However, when used at concentrations of 100 U/ml or higher, it not only impaired platelet generation but also significantly decreased cell number (Figure 6D) without affecting the apoptosis rate (data not shown). These results suggest that IFN β might differentially regulate cellular responses, affecting only platelet production at low levels but affecting the cell cycle at higher levels. That IFN β was responsible for the JUNV-mediated biological effect was further supported by the observation that platelet production was restored to normal values in JUNV-infected cultures when IFN β was blocked by a neutralizing Ab (Figure 6E). To the best of our knowledge, the expression of type I IFN receptor in megakaryocytes has not been previously described. Thus, we examined the presence of mRNAs in purified megakaryocytes. RT-PCR studies revealed that megakaryocyte precursors transcribe both subunits of the IFN α/β receptor mRNAs (Figure 6F). Because another general feature of the cells' response to viral infection is an increase in IFN α production, as a downstream product of the IFN β pathway, this molecule was also studied. Stimulation of CD34+ cells with IFN α mimicked the results obtained with IFN β (data not shown). These results were not surprising bearing in mind that both IFNs are ligands for the same receptor . Overall, these results strongly indicate that the type I IFN signaling pathway may have a key role in the defective platelet release mediated by JUNV in vitro. Considering that in vivo studies showed that megakaryocytes from type I IFN receptor knockout mice are more susceptible to LCMV infection , we next explored the role of type I IFN in JUNV infection. Figure 6G shows that the percentage of infected cells increased from 5% to 10% when the biological activity of IFN β was neutralized. However, recombinant IFN β did not modify TfR1 expression (Figure 6H) suggesting that viral replication in hematopoietic progenitor cells is controlled, at least in part, by IFN β production in a TfR1-independent manner. Although the signaling pathways regulating thrombopoiesis are still under study, Src kinases and several transcription factors have been shown to be involved as regulators of this process . To clarify the mechanistic basis of the impaired platelet production in infected cultures, we first determined whether Src kinases were involved by using a specific inhibitor (PP2). Figure 7A shows that although Src inhibition enhanced platelet release in control cells, it did not prevent the JUNV-induced reduction in platelet number. Fig. 7. Intracellular mechanisms involved in the JUNV-induced inhibition of platelet production. CD34+ cells were UV-irradiated JUNV- or JUNV-infected, washed and stimulated with TPO. (A) The Src inhibitor PP2 (10 µM) was added at the indicated days, and Plt counts were determined at culture day 15. The values represent the mean ± SEM of four independent experiments, * indicates p<0.05 vs. UV-irradiated JUNV-treated cells. (B) Semi-quantitative RT-PCR analysis of relevant molecules involved in megakaryo/thrombopoiesis were performed at the indicated days of culture. The figure shows a representative experiment of three similar replicates. (C) NF-E2 expression was assessed in the megakaryocytic population by immunostaining the cells first with a PE-conjugated anti-CD41 mAb or an isotype-matched control. Then the cells were incubated with anti-NF-E2 polyclonal followed by FITC-conjugated swine anti-rabbit Igs. Cells were analyzed by flow cytometry. Non-specific fluorescence was assessed using rabbit serum instead of primary Ab. The values represent the mean ± SEM of three independent experiments,* indicates p<0.05 vs. UV-irradiated JUNV-infected cells. The histogram shows a representative flow cytometric analysis at day ten. To examine the levels of relevant factors involved in megakaryo/thrombopoiesis, we performed a semi-quantitative RT-PCR assay. We found that the mRNAs of SOCS-1, SOCS-3 and GATA-1, three molecules involved in the initial steps of megakaryocyte development , were similar in JUNV- and UV-irradiated JUNV-infected cultures. In contrast, NF-E2, the main transcription factor regulating platelet biogenesis , was lower in JUNV-infected samples (Figure 7B). In addition, the total amount of NF-E2 protein was moderately but significantly diminished in the megakaryocytic population by viral infection (Figure 7C). Having demonstrated that JUNV infection triggers the production of type I IFN and impairs platelet formation, in the next experiments we examined whether type I IFN was capable of regulating the expression of NF-E2. The results showed that like viral infection, the exposure of purified megakaryocytes to IFN β (Figure 8A) or α (data not shown) resulted in lower NF-E2 expression compared to control samples. Fig. 8. NF-E2 expression and ultrastructural studies of megakaryocytes treated with IFN β. (A) After 12 days of CD34+ cell TPO stimulation, megakaryocytes were purified by immunomagnetic positive selection (98±1% of purity) and NF-E2 expression was determined two or four days after IFN β (10 U/ml) treatment using the anti-NF-E2 polyclonal Ab (or rabbit serum) followed by FITC-conjugated swine anti-rabbit Igs. The values represent the mean ± SEM of three independent experiments, * indicates p<0.05 vs. vehicle. (B) Ultrastructure of megakaryocytes cultured in the presence of vehicle or IFN β from day seven to day fourteen. Inset in the upper panel shows culture-derived platelets observed only in vehicle-treated samples. Because NF-E2−/− mice lack circulating platelets and their megakaryocytes show no cytoplasmic platelet formation , we analyzed the effect of type I IFN on megakaryocytes at the ultrastructural level. Electron microscopic studies revealed that in contrast with control megakaryocytes, which had a lobulated nucleus and abundant cytoplasm with a mature demarcation membrane system (DMS), in the IFN β-treated cells the DMS was almost absent and lacked organization and platelet territories (Figure 8B). The nucleus looked normal and there was a large cytoplasm, but the contents of the megakaryocyte were not evenly distributed throughout the cytoplasm, including areas with missing granules and organelles. Finally, we observed patches of released platelets that were produced only by megakaryocytes in the control cultures. Interestingly, all these observations resemble the NF-E2−/− megakaryocyte phenotype . IFN α induced similar ultrastructural abnormalities (data not shown). In this paper, we present evidence that JUNV infects hematopoietic progenitors in a restricted fashion leading to a significant inhibition of thrombopoiesis, including proplatelet formation, platelet release and platelet function. Previous studies of the effect of viral infection on megakaryocytes derived from CD34+ cells showed that human immunodeficiency virus (HIV), human herpesvirus 6 and human cytomegalovirus negatively affected the survival, differentiation and/or maturation of megakaryocyte progenitors –. In contrast, we here demonstrated that JUNV infection had no significant effect on the proliferation, clonogenic ability or maturation of megakaryocyte progenitors, but it induced a profound decrease in proplatelet formation and platelet release. Although impairment of platelet production has been suggested in HIV patients , , to the best of our knowledge, this is the first time that a viral infection has been shown to selectively affect the two last key steps of thrombopoiesis. It has recently been demonstrated that TfR1 is the receptor for some new world arenaviruses, including JUNV . Our results show that blocking or down-regulating TfR1 surface expression in CD34+ cells significantly reduced both JUNV replication as well as the decrease in platelet formation induced by JUNV infection, indicating that viral infection is a necessary event for the inhibition of platelet formation. Moreover, the fact that UV-irradiated virus had no effect on proplatelet production and platelet release indicates that viral replication is also necessary to hinder thrombopoiesis. These data also implicate TfR1 as the main route of viral entry into hematopoietic progenitor cells. This is particularly relevant considering that it has recently been shown that pathogenic strains can use TfR1-dependent or independent pathways . The observation that JUNV infection up-regulates TfR1 in CD34+ cells could represent a viral dissemination strategy at least in hematopoietic bone marrow cells. However, in vivo experiments will be required to determine its relevance. Remarkably, we found that only 5% of total cells were infected, therefore the observed 50% reduction in platelet production appeared to be due to a selective bystander effect from infected cells rather than a direct effect of viral replication on megakaryocyte biology. Moreover, poly(I:C), a synthetic analogue of the dsRNA associated with the replicative cycle of most viruses , mimicked the effect of JUNV infection. Although transfected poly(I:C) can be sensed by the retinoic induced gene (RIG)-I-like RNA helicases that stimulate IFN α and β expression, naked poly(I:C) is recognized by TLR3, which predominantly stimulates the expression of NF-kB and IFN β . Therefore, IFN β appeared to be a suitable mediator responsible for the reduced platelet production mediated by JUNV infection of hematopoietic cells. Our results showing: a) the JUNV-dependent induction of IFN β mRNA synthesis, b) the suppressive effect of IFN β on platelet biogenesis, c) the expression of both subunits of the IFN β receptor in purified megakaryocytes, and d) the reversion of the inhibitory effect of JUNV on platelet formation with a neutralizing Ab against IFN β strongly suggest that IFN β is a central mediator in the JUNV-dependent inhibition of platelet release. Similar results were obtained with IFN α (data not shown). This would not be surprising as both IFNs are ligands for the same receptor and IFN α is a downstream product of IFN β production and signaling . Furthermore, both cytokines may be the mediators involved in the bystander effect, and this supports the hypothesis that JUNV and any other diseases that are associated with increased type I IFN levels in the bone marrow milieu may result in thrombocytopenia. Surprisingly, despite the low number of infected cells, only few were megakaryocytes. Although we have not yet determined the identity of the vWF negative-infected cells, they could be megakaryocytes with low vWF content because it has been recently shown that treatment of megakaryocytes with IFN α inhibited 70% of vWF RNA expression . In vivo, JUNV may infect other cells in the bone marrow environment, and CD34+ progenitor cells may be exposed to higher levels of type I IFN than produced in our in vitro system. Interestingly, we found that while low IFN β concentrations selectively impaired thrombopoiesis, treatment of CD34+ cells with higher concentrations also reduced megakaryocyte numbers without modifying the apoptosis rate, suggesting an IFN β-mediated cell cycle arrest. Remarkably, both phenomena were independently described by different groups using recombinant IFN α: while Wang et al. demonstrated that IFN α hinders mouse megakaryopoiesis altering proliferation and ploidy , Yamane et al. found that IFN α decreases platelet production without altering megakaryocyte growth . Although these findings appears to be controversial, our results suggest that the levels of type I IFN in the bone marrow could define the cell fate of megakaryocytes, affecting either their proliferation or their ability to produce platelets. Our analysis of the signaling pathways involved in the JUNV-mediated inhibition of platelet production indicated that SOCS-1, SOCS-3, GATA-1, and Src, which are involved in the processes of proliferation, differentiation, and proplatelet formation, respectively , , , were not involved. In contrast, JUNV-infected samples did show lower levels of both NF-E2 mRNA and protein. Interestingly, we also found that type I IFN downregulates NF-E2 in megakaryocytes. As this transcription factor plays a major role in terminal differentiation of megakaryocytes and platelet release , it is conceivable that the reduced synthesis of NF-E2 mediated by type I IFN may be one of the molecular pathogenic mechanisms reducing platelet release in JUNV infection (Figure 9). In fact, thrombocytopenia driven by recombinant IFN α has been related to the selective inhibition of cytoplasmic maturation accompanied by downregulation of the expression of the transcription factors NF-E2, GATA-1 and MafG/HPRT . Our ultrastructural studies using IFN β also showed profound alterations in the cytoplasm that could account for the impaired platelet formation. Additionally, we also found a lower number of platelet granules in type I IFN-treated megakaryocytes. Interestingly, NF-E2−/− mice have no circulating platelets and their megakaryocytes present ultrastructural abnormalities that are quite similar to those of our type I IFN-exposed megakaryocytes . Fig. 9. Model of JUNV infection of CD34+ cells stimulated with TPO. JUNV induces an increase in the expression of TfR1. A very low proportion of megakaryocytes are infected by JUNV, but the infection triggers type I IFN which impairs proplatelet production, platelet release and platelet function. The concomitant down-regulation of NF-E2 in the megakaryocytic population may be involved in this effect. As regarding type I IFN's effect on platelet function, elegant studies from Iannacone et al. revealed that mice infected with LCMV exhibit a type I IFN-dependent platelet dysfunction that, if associated with thrombocytopenia below a critical threshold, results in severe bleeding and acute anemia . Because they did not observe a direct effect of IFN β on platelet activation, they suggested that the platelet dysfunction could be the result of a direct effect of IFN β on parent megakaryocytes or due to the release from endothelium of platelet inhibitors. Our results showing that platelets derived from JUNV-infected cultures had less P-selectin expression upon thrombin stimulation together with the observation that type I IFN-treated megakaryocytes have almost no dense or alpha granules strongly support the hypothesis that megakaryocyte exposure to type I IFN driven by viral infection of bone marrow cells results not only in a reduced number of platelets but also in the generation of dysfunctional platelets. Nevertheless, more studies are required to further elucidate the hemostatic status and to determine whether similar structural alterations are observed in platelets from VHF patients. Do the in vivo data support our hypothesis regarding the critical role of IFN I in the thrombocytopenia present in VHF patients? High levels of circulating IFN a that correlate with virulence and prognosis has been described in different VHF –. Moreover, during systemic viral infection, bone marrow hematopoietic cells appear to be the most important source of type I IFN . In addition, a direct relationship of thrombocyto/neutropenia driven by type I IFN was demonstrated in LCMV infected mice. In that case, however, the condition was mediated by transient bone marrow aplasia . Overall, these data support a role for type I IFN as a pathogenic factor for the thrombocytopenia observed in VHF patients. In conclusion, we provide the first evidence linking viral infection of human hematopoietic progenitors with selective inhibition of thrombopoiesis through the type I IFN pathway. Our studies highlight a potential mechanism that leads to thrombocytopenia and bleeding in AHF and other diseases as a result of an increase in the levels of type I IFN in the bone marrow milieu. These data should be of use in the effort to find new therapeutic strategies for the thrombocytopenia that is associated with VHF. This study was conducted according to the principles expressed in the Declaration of Helsinki. The study was approved by the Institutional Review Board of the National Academy of Medicine, Buenos Aires, Argentina. All patients provided written informed consent for the collection of samples and subsequent analysis. Fluorescein isothiocyanate (FITC)-conjugated monoclonal antibodies (mAbs) against CD34, glycoprotein (GP) IIb (CD41), GP Ib (CD42b), P-selectin (CD62p), phycoerytrin (PE)-conjugated anti-GP IIIa (CD41), unconjugated anti-human HLA-ABC, anti-CD71 Abs, and a fixation/permeabilization kit (BD Cytofix/Cytoperm™) were purchased from BD Biosciences (Franklin Lakes, NJ). FITC-conjugated anti-rabbit immunoglobulins (Igs) and anti-von Willebrand factor (vWF) Abs were obtained from Dako A/S (Glostrup, Denmark). Cy3-conjugated anti-mouse Ig was obtained from Zymed (San Francisco, CA). Recombinant human IFN α2b and rabbit polyclonal anti-human IFN β neutralizing Ab were obtained from Pestka Biomedical Laboratories (Piscataway, NJ). Rabbit polyclonal IgG anti-NF-E2 Ab was purchased from Santa Cruz Biotechnology (Santa Cruz, CA). Random hexamers, SuperScript III reverse transcriptase and Trizol were from Invitrogen. The synthetic analog of dsRNA polyriboinosinic polyribocytidylic acid, poly(I:C) and recombinant human IFN β1a were obtained from InvivoGen (San Diego, CA). The Src family kinase inhibitor 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP2) was obtained from Biomol International LP (Plymouth Meeting, PA). Thrombopoietin (TPO) was obtained from Peprotech (Veracruz, Mexico). All of the other reagents were obtained from Sigma Chemical Co. (St. Louis, MO). Isolation of CD34+ cells was performed as previously described . Briefly, human umbilical cord blood was collected during normal full-term deliveries and was used within 24 hr. After collection, samples were diluted one to three with PBS and centrifuged to remove platelets. Low density mononuclear cells were prepared by centrifugation of the remaining blood over a Ficoll Hypaque. Cells collected from the interface were washed, and CD34+ cells were purified using a magnetic cell-sorting system (Miltenyi Biotec, Bergisch Gladbach, Germany) in accordance with the manufacturer's recommendations. After two Mini-MACS column separations, the purity of the cell suspension was determined by flow cytometry and typically ranged between 95 and 99%. Cell viability was greater than 90%. Fresh CD34+ cells were used for each experiment. Mature megakaryocytes were purified by immunomagnetic positive selection from TPO-stimulated CD34+ cultures on day 12 using anti-CD41 magnetic beads (Miltenyi Biotec) following the manufacturer's instructions. The purity of the final cell suspension was ≥95% and cell viability was greater than 80%. Monolayers of Vero-76 cells (CRL-1587, the American Type Culture Collection (ATCC), Manassas, VA) were grown in minimum essential medium (MEM) containing 10% fetal calf serum (FCS) and antibiotics. A virulent strain of JUNV originally isolated from an AHF patient (P3441) was kindly provided by Dr. A. Ambrosio of the Instituto Nacional de Enfermedades Virales Humanas “Dr. Julio I. Maiztegui”, Pergamino, Argentina. Virus stocks were grown, identified, and quantified as described previously by using the JUNV-susceptible Vero-76 cell line. Virulence was tested in three-week-old guinea pigs and the median lethal dose, (LD50), assayed between 11 and 14 days p.i., was ≤10 PFU. When required, virus was subjected to UV inactivation for 20 min using a 365 nm UV bulb positioned 5 cm over the stock . CD34+ cells (1×104) or a monolayer of Vero-76 cells were inoculated with JUNV at a multiplicity of infection (MOI) of one or the equivalent volume of UV-irradiated virus for 1 hr at 37°C. Mock-infected controls contained supernatants of Vero cells instead of JUNV. After washing, UV-irradiated JUNV-, JUNV- or mock-infected CD34+ cells were cultured in Iscove's Modified Dulbecco's Medium (IMDM, HyClone) containing 2 mM glutamine, 5% human serum (obtained by re-calcification of citrated platelet-free plasma), 25 ng/ml TPO and antibiotics (growth medium) at 37°C in a humidified atmosphere with 5% CO2 . Fresh TPO (25 ng/ml) was added at day seven. Vero-infected cells were cultured for seven days in MEM containing 2% FCS and antibiotics. Cells were washed with PBS (Ca2+- and Mg2+-free), cytocentrifuged on silanized glasses, fixed with 1% paraformaldehyde (PFA) for 20 min and permeabilized with 0.1% Tween for 10 min. The slides were incubated overnight at 4°C with a pool of specific mAbs against JUNV and a rabbit-anti-human vWF polyclonal Ab to identify megakaryocytes. FITC-conjugated anti-rabbit and Cy3-conjugated anti-mouse Igs were then applied to the PBS-washed slides for 30 min at room temperature (RT). Abs were diluted with PBS containing 5% fetal bovine serum and 5% goat serum as blocking agents. The slides were counterstained with DAPI and examined under an Olympus BX60 microscope equipped with a 100× PlanApo objective (NA 1.4) and a 100-W mercury lamp. Images were acquired with an Applied Imaging Model 4912–5010/0000 charge coupled device (CCD) camera. Electron image acquisition was under the control of Cytovision software. For flow cytometric studies, samples were washed, fixed with 1% PFA for 20 min, and permeabilized with 0.1% saponin for 10 min. Cells were then incubated for 1 hr at RT with a pool of specific mAbs against JUNV and a rabbit-anti-human vWF polyclonal Ab. After two washes, FITC-conjugated anti-rabbit and Cy3-conjugated anti-mouse Igs were diluted in 0.1% saponin and added to the samples for 30 min and analyzed on a FACSCalibur flow cytometer using CellQuest software (BD Biosciences). Negative controls were performed using uninfected cells or omitting primary Abs. JUNV-susceptible Vero cells were used as a positive control. The levels of CD34, CD41 and CD42b in the TPO-stimulated CD34+ cell cultures were measured by immunostaining with saturating concentrations of specific FITC-labeled mAbs or an isotype-matched control after varying numbers of days. After 30 min of incubation, the samples were fixed with 1% PFA and analyzed by flow cytometry. To evaluate megakaryocyte ploidy, cells were centrifuged for 10 min at 220×g, washed and fixed in 70% ethanol at −20°C overnight. Cells were then washed, resuspended in PBS, and incubated for 30 min at RT with saturating concentrations of FITC-conjugated anti-CD41 (or isotype control), 1 µg/ml propidium iodide, and 10 U/ml RNaseA. Cell ploidy was analyzed by flow cytometry. Aliquots of 5×103 CD34+ cells were resuspended in collagen-based, serum-free medium containing 50 ng/ml TPO (MegaCult, Stem Cell Technology, Vancouver, Canada) and seeded in double-chamber culture slides. After 12 days, megakaryocyte colonies were detected using an anti-CD41 antibody and an alkaline phosphatase detection system and were then counterstained with Evan's Blue. Two categories of colonies were identified: pure megakaryocyte colonies and mixed megakaryocyte colonies (distinguished by the presence of non-megakaryocyte cells within the same colony). Pure megakaryocyte colonies were scored according to their size: small CFU-megakaryocytes (3–20 cells), medium CFU- megakaryocytes (20–50 cells), and large CFU-megakaryocytes (>50 cells). PPF was analyzed as previously described with some modifications . Twelve-mm glass coverslips were coated with 100 µg/ml fibrinogen for 2 hr at RT and subsequently blocked with 1% bovine serum albumin for 1 hr. Cells cultured for 12 days were harvested, plated on coated coverslips in 24-well plates (1×105 cells per well) and allowed to adhere for 4 hr at 37°C and 5% CO2. PPF was then evaluated by fluorescence microscopy by staining cells with TRITC-conjugated phalloidin. DAPI was used as a counterstain. Proplatelet-forming megakaryocytes were identified as large cells exhibiting long filamentous structures. The extent of PPF was calculated as the percentage of proplatelet-bearing cells by counting 500 cells per treatment. Platelets were counted using flow cytometry as previously described . Briefly, cells were incubated with a FITC-labeled anti-CD41 mAb for 15 min and fixed with 1% PFA for 20 min. Cells from each culture condition were distributed in the same volume. For each sample, the acquisition rate was 1 µl/sec for 100 sec. Events were collected without gating using a log scale for size (FSC) and intracellular granularity (SSC). An analytical gate was determined based on the scatter properties of normal blood platelets treated similarly to the culture-derived platelets. This gate excluded large contaminating cells and small debris or microparticles. Culture-derived platelets were counted as CD41+ events with the same scatter properties as blood platelets. P-selectin expression on platelets was determined as previously described with minor modifications . Briefly, culture-derived platelets were isolated by centrifugation at 1000×g in the presence of PGI2 to avoid platelet preactivation. The pellet was resuspended in modified Tyrode buffer (134 mM NaCl; 2.9 mM KCl; 0.34 mM Na2HPO412H2O; 12 mM NaHCO3; HEPES 20 mM; MgCl2 1 mM; glucose 5 mM, pH 7.3) and left to rest for 30 min at 37°C. The suspension was stimulated with 1 U/ml thrombin for 10 min at 37°C. After fixation, cells were stained with anti–P-selectin (CD62p)–FITC and anti-CD41-PE mAbs for 30 min and P-selectin expression was measured by flow cytometry using the characteristic forward and side scatter pattern of normal blood platelets treated similarly. To determine the level of TfR1 expression on TPO-stimulated CD34+ cell membranes, cells were incubated with a FITC-conjugated anti-CD71 or an isotype-matched control mAb at the indicated days p.i. Samples were washed, fixed, and analyzed by flow cytometry. CD34-derived megakaryocytes were tested for NF-E2 expression using a double-labeling technique (NF-E2/CD41). Cells were immunostained with a PE-conjugated anti-CD41 mAb or an isotype-matched control and fixed with 1% PFA at 4°C. After washing with PBS containing 0.1% saponin, cells were incubated first for 30 min in the same buffer with anti-NF-E2 polyclonal Ab at 4°C and then with FITC-conjugated swine anti-rabbit Igs. Cells were analyzed by flow cytometry. Non-specific fluorescence was assessed using rabbit serum instead of primary Ab. In selected experiments, NF-E2 expression was determined in purified mature megakaryocytes treated with type I IFN using the anti-NF-E2 polyclonal Ab (or rabbit serum) followed by FITC-conjugated swine anti-rabbit Igs. Total RNA was isolated from cell pellets using Trizol as recommended by the manufacturer. cDNA was synthesized from 20 ng of total RNA using 15 mM of random hexamers and SuperScript III reverse transcriptase according to the manufacturer's instructions. The cDNA samples were diluted 10-fold, and the PCR reaction was conducted at the annealing temperature of 55°C. All reactions were confirmed to be within the linear range of amplification. The primer sequences and sizes of the amplified fragments are included in Table 1. Tab. 1. Primers used for RT-PCR (5′→3′). The following symbols were used for mixed bases: W, A:T; N, A:C:G:T. Megakaryocytes were fixed with 1.5% glutaraldehyde in 0.1 M cacodylate buffer, pH 7.4, for eight hr. Cells were dehydrated through a series of alcohols, infiltrated with propylene oxide, and embedded in epoxy resin in an inverted beam capsule. Ultrathin sections were stained with uranyl acetate and lead citrate and examined with a Tecnai G2 Spirit BioTWIN transmission electron microscope (Hillsboro, OR) at an accelerating voltage of 80 kV, and images were recorded with an AMT 2k CCD camera (Danvers, MA). All results are expressed as the means ± SEM. Student's paired t test was used to determine the significance of differences between means, and p values lower than 0.05 were considered to be statistically significant. When multiple groups were compared, one-way analysis of variance (ANOVA) followed by the Newman-Keuls procedure was used to determine significant differences between groups.

2019-04-25T12:20:02Z

https://www.prolekare.cz/casopisy/plos-pathogens/2010-4/junin-virus-infection-of-human-hematopoietic-progenitors-impairs-proplatelet-formation-and-platelet-release-via-a-bystander-effect-involving-type-i-ifn-signaling-45715

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2019-04-23T04:11:14Z

https://ozolins.info/motivation/case-study-on-google.php

Ever heard about the Earth being flat? Well… there are certain people who believe that our blue planet is not the sphere depicted on TV or our geography textbooks… but is a flat disc! While there is enough evidence that a flatter earth would not benefit us in any way (we’d be falling off the edges), ‘flatter might be better’ when it comes to organisational structures… Or is it? Biased bosses, time-consuming paperwork and a seemingly endless list of people to chase for obtaining approvals are elements that may incite an HR professional to wonder if maintaining clear hierarchies is truly necessary or not. The alternative to this is a flat organisation, which seems to paint a rosy picture… at least from afar! Let’s zoom in and take a closer look to help you make a well-informed decision regarding your organisational structure. What Is A Flat Organisational Structure? A hierarchical structure in which the number of superior-subordinate relationships is minimised is called a flat organisation. In order to understand it better, visualise this: there is a staircase that connects the bottom-most floor to the top floor. Keeping the height of the staircase constant, the number of steps is reduced. This process is called flattening and the result is a flat organisation. It is not possible to do away with the staircase altogether, but by increasing the height of each individual step, it is possible to bring down the number of steps. In this analogy, each step in the staircase denotes one designation or level of authority. So, the bottom-most floor represents the junior-most (or entry-level) post in an organisation while the top floor corresponds to CXOs. As a result of the lowered number of checkpoints, information passes faster from one level to another. This reduces the time taken for decisions and frees up time for business development. The average span of control (the number of subordinates per superior) increases, along with the authority and responsibility borne at each level. Employees have more decision-making power and the contribution of each resource assumes greater significance. Needless to say, this type of structure has its advantages. The most impactful ones are discussed below. Since the number of people in the chain of command is lower, information is transmitted faster. This minimises the scope for miscommunication making action points clearer. It also saves time. The work that has to be done merely as part of the formalities will be lower in a flat organisation. Multiple modes of intimation for the communicating the same idea is a redundancy that can be eliminated in a flat organisation. For example, instead of a physical form submission, an online application and an email to obtain permission from various levels, one of the above would be sufficient. The response time taken for a particular idea is faster in a flat organisation. This improves the overall efficiency of the organisation. From an individual employee’s point of view, an organisation with a relatively flat hierarchy is far less frustrating to work in since the bureaucracy is very low compared to a conventional organisation. The Downside Of A Flat Organisation Structure! While the advantages of a flat organisational structure might seem enticing, the pitfalls of incorporating such a structure cannot be ignored! The spirit of a flat organisation is sharing of responsibilities along with authority. When there are many people at the same level, the responsibilities are shared between them. Also Read: Reskilling Is The Need of The Hour! While it is not impossible to allocate tasks to each person, invariably there are some common ones which also need to be completed. If one such task is not attended to, there is no single person who can be held responsible for its non-completion. The lack of accountability for certain areas or deliverables is a drawback of this type of organisational structure. In a large corporate with a long chain of command, each person’s role, deliverables, power and impactfulness are fairly well-defined. The fluidity is relatively low. This rigidity brings structure and clarity. It gives a sense of direction for each employee and they need spend time on figuring out what is expected out of them. In a flat organisation, one may have to have multiple discussions with his/her colleagues regarding the division of work. This gives scope for some friction. There might be cases where roles by themselves, independent of the people associated, overlap. In such times, the problem of lack of role clarity is magnified. Humans are social animals; they have the natural tendency to form groups, just like other animals with a herd mentality. This leads to two major issues in the context of flat organisations. Firstly, when a cluster is formed, the ones who are extroverts or are power-hungry might arrive at an informally superior position, even if they are not particularly good at their work or have other commendable skills that impact the tasks. This takes away the limelight from the real performers and leads to an unfair hierarchy that is not formalised. Also Read: Here Are 6 Things We Learnt After Reviewing Multiple Job Descriptions Of Various Companies! Secondly, informal interactions can supersede formal communication. Since everyone at a particular level is equal, the power lies with everyone to go around and make conversation. This can strengthen the grapevine. A strong informal network can make or break the organisation’s culture and impact employee productivity. If it has a negative impact, it can even cause the turnover to increase. A flat organisational structure gives scope for the quality of output, efficiency and effectiveness to dwindle. This is because people usually find it uncomfortable to question or exert authority over the way others work when they are at the same level. The lack of formal authority can contribute to sluggish performance. Are Flat Organisations Feasible For All Organisations? Clearly, a flat organisational structure is not suitable for every organisation. As an HR professional, deciding whether to adopt this or not is a crucial decision that needs to be given adequate thought. Generally, this type of structure works well in small organisations where employees are highly passionate and motivated. However, nothing is set in stone. It is possible to adopt this style by bringing about a few changes. The first and foremost is establishing a culture where all employees feel respected and appreciated regardless of their designation. This will automatically boost their morale. The second is to imbibe a deep sense of ownership so that they are proactive about their work. Thirdly, providing clarity on all aspects of work, analysing the overlaps and dividing the work equally at a granular level can reduce the scope for confusion or underperformance. All this needs a lot of time, energy and effort, and might become too overwhelming in the case of larger organisations! Perhaps, when it comes to them, and our blue planet, being flat may not be the best thing! The Busyness Syndrome: What Is It And How To Ensure Your Employees Don’t Fall Prey To It!

2019-04-21T06:39:39Z

https://allthingstalent.org/2018/07/11/organisations-better-off-not-flat/

Kia Picanto User Manual Download - View and Download Kia Picanto 2014 owner's manual online. Picanto 2014 Automobile pdf manual download.. View and Download Kia Picanto 2016 owner's manual online. Picanto 2016 Automobile pdf manual download.. HiCOM key teaching manual www.obdtester.com/hicom Hyundai/Kia key teaching Table of Contens 1.SMARTRA introduction.2. Find Kia at the best price. We have 15 cars for sale for kia table view, priced from ZAR129,500. The 2019 Kia Rio, a compact car with the latest technology, Autonomous Emergency Braking (AEB), Lane Keep Assist, Apple CarPlay and Android Auto as standard. 5 year warranty and great fuel economy. Explore the specifications of the Kia Cerato Hatch, from powertrain and technical features, to safety, interior and exterior. View the Cerato Hatch range today.. renault laguna2 by obd2; mb w164/w251/x164/w219/w221/w216 by obd2; volvo xc60/s80/v70 since 2008 by obd2; bmw cas/cas2/ cas3 / cas3+ by obd2 or cluster-plug; chrysler. update 02/26/2018 (version:0305.0027): immo: audi immo 4th system / q2 06.2014- nec35xx key adaption : by obd2: audi immo 4th system / a3 06.2014- nec35xx key adaption. The Hyundai i10 is the global successor to what we knew in India as the Santro Xing. A city-friendly hatch, the i10 had a clean run in the market, often topping the sales charts for Hyundai.. Find used car at the best price. We have 14 cars for sale for under administration, priced from ZAR6,500. The Volkswagen up! is a sensible city car that has practicality, style and fun driving up its sleeve The Volkswagen Up is more sophisticated than its size and looks suggest. It’s comfortable. View the new and used Mazda cars, parts and servicing available from Barnetts Motor Group in Barnetts Mazda.. The Lookers Family. Choose from a wide selection of over 10,000 cars across our entire network with confidence.. When you drive a Mazda, you never drive alone. Hendy Mazda Tunbridge Wells, Hendy Mazda Brighton - Mazda Authorised Repairer, Hendy Mazda Eastleigh, Hendy Mazda Crawley, Hendy Mazda Eastbourne, Hendy Mazda Horsham and Hendy Mazda Winchester - Mazda Authorised Repairer offer a wide range of servicing solutions to keep car and driver in perfect harmony..

2019-04-24T09:49:46Z

https://nj-history.org/kia-picanto-user-manual-download.html

Shohei Ohtani is the Japanese version of a young Babe Ruth. Do the Cubs have a legit shot? They do according to multiple reports including the latest from insider David Kaplan. "MLB sources have confirmed to me that the Cubs have spent significant time and money in their pursuit of Ohtani," Kaplan said. "The club has sent multiple scouts to Japan for weeks at a time and they have watched him pitch and play the outfield and they believe he can indeed do both on the north side of Chicago." A National League executive told Kaplan that Theo Epstein is going hard after him. "Theo has been fascinated by this kid for a long time," the executive said. "He and Jed have been strategizing on how to land him in Chicago. They have the support system needed to make this work. They landed Daisuke Matsuzaka when he was in Boston and they have a good relationship with Ohtani’s agent (Nez Balelo) at CAA. "They are definitely one of the teams on his short list. But will he end up in the National League? That’s the big challenge." This is a 23-year old prodigy that can throw 102.5 MPH and hit titanic homers. Just imagine the versatility that Joe Maddon would take advantage with him in the lineup on a daily basis. Think Travis Wood but just 1000% better and younger.

2019-04-21T12:43:09Z

https://www.cubshq.com/update/Report-Cubs-want-Ohtani-to-pitch-and-play-outfield-24099

I had a comment on my blog recently asking for information, help or advice on emigration. Rather than reply individually I decided to write the how’s and why’s to share my experience of how we got here and why we chose the method we did and our experiences so far. This page will be updated constantly as we discover new things. The research began the day we decided to make the move with a trip to WH Smith to buy magazines. There are a few emigrating/living abroad magazines out there where people can share their experiences and companies who specialise in moving abroad advertise their services. We also discovered there was a road show held by www.emigrate2.co.uk and immediately bought tickets to their next available show and booked ourselves into one of the presentations that took place on the visa application process. The whole day was an invaluable source of information and I can’t recommend the experience enough to anyone starting the process. Our second source of information was, of course, the Internet. The Citizenship and Immigration Canada Website describes all the different categories to apply under and you can apply directly from there. There are many categories and the requirements differ by the province you are applying to. The site has all the forms you need to make your application you can track your application progress online. Online Forums such as Britishexpats.com are also full to bursting with help, guidance and information. These forums are constantly updated to keep up with the rapidly changing Visa application process. Having researched all the choices we chose the Skilled Worker Category as my husband had qualifications in Mechanical Engineering. We decided to apply for permanent residency (PR) while we were still in the UK as we thought it unfair to move the boys (aged 16 & 10 when we moved) while on a work permit. We were willing to wait out our time on the UK while preparing to emigrate but with the knowledge that once we had our PR visas and landed in Canada we could stay here permanently regardless of whether we had jobs or not (providing we didn’t turn into mass murders or something!) However many people come on a work permit and then apply for residency when they arrive, a process which takes about 18 months at the moment. The downside of this way is that your residency is dependent on your employment and if that changes you may have to leave the country. We simply didn’t want to take that chance with the boys but had we not had a family to consider we probably would have opted for this route. We chose not to use an agent because our application was relatively straight forward and simple and I was happy to carry out the paperwork myself. Citizenship and Immigration Canada do not process the application any differently regardless or if you use an agent or not, it wont happen and quicker but would cost you a more to use an agent so unless you have to there really is no need to pay someone to do it for you. Questions that always come up when contemplating a move are what is the cost of living, how is the job market and what is the work-life balance like. You need to know if the upheaval will be worth it right? Well here in the GTA (Greater Toronto Area we are in somewhat of a bubble that is different from much of the rest of the country. Prices are generally higher here than elsewhere. There are some general rules though that are the same country wide. We have found the cost of living is similar to the UK however we spend our money on different things. For example housing, household bills, fuel and clothing are cheaper here but food, alcohol, car insurance, mobile phone and internet costs are more expensive. Canadians love education and Degrees are hugely important. Many jobs openings require degrees even for very junior positions. If you are qualified or have a trade, work is relatively easy to come by but if you do not have a niche or skill it can be difficult to get yourself noticed amongst hundreds of other applicants. Generally unemployment here is low but Canadian work experience is deemed important so finding work as a newcomer can be challenging. Without a doubt life here is less stressful than the UK, the work/life balance is much better. The average work day is shorter than in the UK and commuting times are shorter.

2019-04-19T15:23:02Z

http://louslakeviews.com/thinking-of-emigrating-to-canada/

Arzu Kaprol graduated from MSU-Istanbul Fashion and Clothing Dept. She studied at Paris American Academy. She established her brand with several awards especially the prestigious Beymen prize. In Turkey after signing a license agreement with luxury group Beymen, she has been able to expand a strong retail presence. After being invited to be member of Paris Fashion Week she is showing on international official schedule. The Arzu Kaprol PAP collection continues to expand internationally and in July 2011 she started to work with the department store Harrods in London. With the Atelier collection she has already dressed celebrities such as Meg Ryan, Kelly Rowland and Gisele Bundchen. And more recently Angela Lindwall at the 2011 amfAR Gala and the closing ceremony of the Cannes Film Festival.

2019-04-24T10:55:35Z

http://www.turkishfashion.net/Fashion-Designers/arzu-kaprol/2685

BRIEF : Amelie and Salim, an interfaith couple from London, wanted to do something out of the ordinary for their wedding, which would reflect their personalities and shared love of travel. We proposed dividing the celebrations into two sections: home and abroad. For the formal part of the wedding we suggested the civil ceremony be conducted on the London Eye with a private dinner for family at The Ivy, followed two days later by flying a group of friends to Mykonos for a Buddhist blessing and a weekend of celebrations. As busy professionals, it was imperative to Amelie and Salim that all aspects of this spectacular two-centre wedding were taken care of by us. They specifically requested that all decorations and favours were shipped to Greece from the UK and required us to take the reins on everything from location scouting, venue, flights and accommodation to flowers, menus, music and fireworks. We were to be on site at both locations, ensuring a smooth transition between the two and coordinating everything from Champagne on board the London Eye to excursions on the island. RESULT : The London Eye was the perfect backdrop for the formalities. Their guests were divided into two pods and by the time they were officially married they were surrounded by the sights of London. With a crooner for entertainment at The Ivy and a stunning chocolate box cake, the UK wedding was an elegant, stylish affair. The beautiful island of Mykonos was the perfect setting for the second part of this celebration of love. Luxury boutique hotel Bill & Coo provided breathtaking views across the Aegean Sea from its twinkling infinity pool and offered peaceful seclusion for this special occasion. Over the course of the weekend, guests were treated to a string of private boat trips and barbecues on the beach, culminating in Amelie and Salim reaffirming their commitment to each other with a simple Buddhist ceremony at sunset. Adding to this already unforgettable wedding was a very special Buddhist ritual using lanterns and ribbons, carried out by their closest friends. Dinner was served beside the infinity pool, followed by the release of paper wishing lanterns into the sky and an informal party which lasted long into the night.

2019-04-18T14:17:33Z

http://potcakes.com/case-studies/amelie-salim

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2019-04-25T03:56:41Z

http://gokgs.com/tournGames.jsp?id=501&round=12

Termites are one of the most destructive forces in the world, despite their small size. An infestation can cause thousands of dollars worth of damage that can put your family’s health and safety at risk. Whether you’re dealing with an infestation right now or you just want to avoid one in the future, there are preventative steps you can take to steer clear of disaster. Do you have a termite problem right now? Call Termishield in South Bend so our professional pest control experts can take care of it for you. Like many insects, termites thrive off of moisture. This makes it very important to minimize those sources of moisture so they don’t have anything to take advantage of. This includes, but is not limited to, repairing leaky faucets and pipes, fixing exterior air conditioners, and repairing leaking gutters and roofs. Another step you can take to help this is keeping your gutters clear of debris. When gutters are clogged up, water will accumulate and won’t have the ability to flow away from your home. That accumulation of rainwater then becomes a source of moisture for termites looking to survive. As you know, wood is a termite’s favorite meal. If you have wood on the exterior of your home, it’s extremely important for you to keep a close watch on its condition. While you might not notice signs of damage immediately, as termites like to start chewing away from below the surface, you can still find clues that they’re around. For instance, small, pellet-shaped droppings near the wood are a clear indication that you have termites in the area. Whether you have a stack of firewood ready for the fireplace or you have lumber, sawdust, or mulch nearby from a project you’re working on, this can act as a buffet for hungry termites. Don’t give them the chance to get close to your home by placing it nearby. It is recommended you keep these items at least 20 feet away from your house. Additionally, if you have any damaged or infested trees in your yard, they should be removed as soon as possible. With how quickly termites can do damage, it’s important you stay vigilant with checking around your home. Focus on your foundation and keep an eye out for mud tubes and wings. Mud tubes are created by termites out of their droppings and soil while they are looking around for food. You’re likely to find wings near windows, where they are most likely to shed. Unless you’ve been trained, you might not catch some of the more nuanced signs of a termite infestation. Get assistance from a professional pest control expert on an annual basis, as they’ll be better equipped to both identify an infestation as well as treat it to avoid further damage. For homes in South Bend, Termishield is proud to provide exceptional pest control services. If you have noticed signs of an infestation or you just want some peace of mind, call today to schedule your inspection. We hope to hear from you soon!

2019-04-18T16:23:03Z

https://www.termishieldpestcontrol.com/termite-control-south-bend/5-ways-to-prevent-termites/

Criminal charges are heard in the Superior or Municipal Courts. An experienced attorney will treat all charges in the same manner. Proper investigation and motion work is essential on felony charges. This same work ethic and practice is even more successful in municipal cases. The sooner an attorney can begin work on your case the more can be accomplished. The range of information needed if you are charged with a criminal offense cannot be placed on an information sheet. The most common charges are listed below. You should consider retaining counsel as early as possible. There is evidence that is destroyed unless properly requested and preserved. Witness statements need to be preserved as well as the appearance of the scene. If the case is indictable, certain information should be sent to the County Prosecutor that may influence their action on the case. Municipal Courts hear all disorderly persons offenses and municipal ordinances. These are violations that carry less than one year in jail. Any offense that could result in one year in jail or more is a felony and must be heard at the County Superior Court level. However, the County Prosecutor may downgrade the charge and send the lesser charges back to the Municipal Court. An experienced attorney may be able to assist in the process to lessen the charge, or for other tactical reasons may decide that you would benefit by having the case remain at the County level (certain programs available at the County are not available in Municipal Court). Disorderly and petty disorderly persons offenses: Disorderly persons offenses carry a six-month possible jail sentence, up to $1000 fine, possible community service and possible probation period (there are some exceptions). Petty disorderly offenses carry a possible jail sentence of 30 days, up to $500 fine, possible community service and possible probation. Both offenses require a $75 SNA penalty and a $50 VCCB penalty and court costs. Normally first convictions only result in a fine. Common disorderly persons offenses are: Simple assault, 2C:12-1; Shoplifting, 2C:20-11 (under $200); Theft/theft of services, 2C:20-8 (under $200); False information, 2C:28-3; Resisting arrest, 2C:29-2. Common petty disorderly offenses are harassment, 2C:29-2; and fighting, 2C:12(a)3. Drug Charges: N.J.S.A. 2C:35-10; 36-2, all drug and paraphernalia possession charges carry a mandatory six-month loss of license and $500 DEDR penalty, in addition to the penalties for a disorderly or petty disorderly offense. Possession of any drug other than marijuana is a felony; however, the charge may be sent back to Municipal Court as a nonpossession charge, such as 2C:35-10(c). First offenders may be eligible for a program that will not result in a conviction; however, this program still carries fines, probation, computer record. Retain counsel as soon as possible. Many clients believe that retaining counsel is not necessary until they are indicated by the Grand Jury. This is an extremely dangerous decision. Radio transmissions and crime scene evidence may be lost. Witness statements need to be obtained. The state is required to present exculpable testimony to the Grand Jury only if they have such information. This information may alter a decision to proceed with charges. A domestic violence charge proceeds extremely quickly. The "burden of proof" for conviction is low and judges side with the complainant. However, the consequences may be dire: A permanent restraining order, support payments pending other Court action, loss of weapons ownership for life. This procedure can also be used to interrogate state witnesses for the more important criminal case. A felony is a charge carrying a one-year incarceration. Felonies range from fourth-degree (possession of a knife, distribution of marijuana under 50 grams) to the third-degree theft offenses and second-degree assaults, to first-degree murders. First offense third-degree (three-five years) and fourth-degree (18 months) charges carry presumption of non-incarceration in state prison. Second-degree (five-10) and first-degree (10-20 years) charges presume state prison incarceration. First-degree murder charges carry enhanced penalties as does kidnapping (30 years without parole; death). Numerous statutes carry enhanced penalties in addition to the terms indicated above and mandatory state prison terms. Probation on any charge can result in 364 days in the County jail. Diversionary programs are available for first offenders. All of these charges require immediate experienced legal attention. The prosecutor's position can be effected by any information. Legally, the prosecutor needs to present the Grand Jury only with information in its possession. Options available to a client decrease the longer the case proceeds. Seek counsel.

2019-04-23T22:16:07Z

https://www.866crimlaw.net/Criminal-Defense-Overview/New-Jersey-Criminal-Courts.shtml

Hammond Place is located in a tree lined residential neighborhood in North Augusta, South Carolina. We are close enough to both the Savannah River and Lake Thurmond for day trips. We also take regular trips to town for shopping, visiting restaurants and enjoying all of the entertainment our wonderful city has to offer. All resident rooms have either a view of the wooded areas surrounding our property or of our enclosed flower filled courtyard. Our large apartments are perfect for either single or double occupancy. All apartments have a kitchenette with refrigerator and microwave if you want to cook your own meals or you can join friends in our spacious restaurant style dining room. We offer plenty of opportunities for socializing in our comfortable lounges and through our varied activity schedule. Activities include a walking club, Tai Chi, musical entertainment, crafts and pet therapy. We also have an on-site beauty salon, computer stations with internet access and accommodations for overnight guests.

2019-04-26T15:36:00Z

https://www.aplaceformom.com/community/hammond-place-81081

Start it up and it turns into a Volkswagen. Twist the key of the Karmann Ghia, and all kinds of wonderful things happen. For one thing, the motor starts. Don't laugh; a lot of other conventional engines might not. Especially on a miserably cold winter morning. The reason the Ghia revs right up is because it's got one of those air-cooled Volkswagen engines in the back. Drive a Ghia for a while, and your gas ond oil bills will fall into that economical Volkswagen tradition. Tires will take you some 40,000 miles, Volkswagen style. You'll get that remarkable Volkswagen traction. The easy availability of Volkswagen parts. The reasonably priced Volkswagen service. Ditto for everything else Volkswagen. But there is one thing that's a far cry from our beetle- nosed job: the Karmann Ghia's beautiful Italian-designed body. So you can start it up, turn into a little bug, and nobody will know you're undergoing a metamorphosis. Except you. /:. " "" " --- ' ' , l / :.- ::= -. .,; ,.-. y...... y,"' .' .........y.y.. ""'- ,.:;< - --:- --:" : , ""'\ . y: . ""''''''';' ,,,,,,"...;:: ""'"'' 1"" ' """""":.;......- , ,.., ' ' -"__...,1IIIIL '\ ...::::'_ .....no .1 '"" , '", '\ r" ._ ., ,.".op .,. ..( ,:_.... ,....:u::.. ! 1 ""'I It:J '\; "', i II" i '. J\' i: C;,' , (1, " ,-. .. .. ,... ----. '[ , -.. ';;' , -- ' " .--'!:. -- ......- -- ,;.... ,\ 1 ;) ...".' - -"/ ... ,Jilt .....- @ VOLKSWAGEN. OF AMERICA, INC.

2019-04-25T12:06:03Z

http://archives.newyorker.com/?iid=18733&startpage=page0000127

ESTERO, Fla. — Texas took its first two major punches of the season, and escaped with a win anyway. Audrey Warren’s jumper from just inside the foul line with 47 seconds left lifted the 10th-ranked Longhorns to a 56-55 win over Quinnipiac on Friday in the opening round of the Gulf Coast Showcase, a victory that might go down as a costly one for Texas. Quinnipiac, the reigning Metro Atlantic Athletic Conference champions, led for 34 1/2 of the game’s 40 minutes, then rolled with Texas through a back-and-forth final quarter before getting two shots at the end to win the game. Jen Fay’s long jumper missed, and Taylor Herd’s putback try bounced off the rim as time expired. Fay led all scorers with 15 points for the Bobcats, who shot 19 per cent in the second half, 1 for 15 from 3-point range in that span. Higgs’ injury came when she planted near the basket and then tumbled to the floor, letting out several long screams of obvious distress as she grabbed at her knee. She was carried off the floor by two Texas staffers for evaluation, and there was no determination after the game about the severity of her injury. Everything was going Quinnipiac’s way early — and Jaden Ward kept finding herself in the right place at the right time. The rebound of Bacchini’s miss went bouncing toward the far corner. Mackenzie DeWees ran it down then heaved it with both hands, no-look, over her head, toward the basket. Her toss went directly to Ward, who laid it in for a 33-22 lead. “Obviously, the first 20, we were pretty dominating defensively,” Fabbri said. Quinnipiac: The Bobcats are now 0-8 all-time against teams ranked No. 10 or higher. In the other seven meetings, the average score was 93-51 — though that’s also wildly skewed by a 117-20 loss to UConn 20 years ago. Texas: The Longhorns didn’t get a warmup for the second half; the Longhorns didn’t return to the floor until about 30 seconds were left in the 15-minute intermission. “We were a little shellshocked,” Aston said. The Longhorns are now 16-4 in the state of Florida. Quinnipiac has had big success in the Sunshine State as well; it downed Marquette and Miami in the 2017 NCAA Tournament, on its way to the Sweet Sixteen. In Texas’ first three games of the season, a total of 120 minutes, the Longhorns led for 117 minutes, 57 seconds. They were tied for the other 2:03. Texas meets Michigan in the semifinals. Quinnipiac plays Missouri loser in the consolation semifinals.

2019-04-19T17:03:12Z

https://nationalpost.com/pmn/sports-pmn/no-10-texas-barely-survives-quinnipiac-56-55

There are many different types of fire ants, and they are found all throughout the southeastern and southwestern United States. The most common and aggressive kind is the red imported fire ant, which is reddish-brown and measures about 1/8-inch long (about half the size of a pencil eraser). Red imported fire ants’ nests can be found on lawns, in parks, on playgrounds, in fields, and in pastures. Some red imported fire ants create nests in walls of buildings. A person who gets stung by a fire ant will feel a sharp pain and burning. A person who steps on a fire ant mound will get a lot of stings at once because the ants have been disturbed where they all live together. Each sting will turn into an itchy white blister over the next day. If you ever think that you have been stung by a fire ant, tell an adult immediately. That’s because the venom (poison) in the fire ants’ stings can cause the area of the sting to swell up quite a bit, and a doctor may want to have a look to make sure you are not having an allergic reaction. The symptoms of an allergic reaction include hives (red patches on the skin that sting and itch), nausea, dizziness, a tight feeling in the throat, or difficulty breathing. If these symptoms occur, the person needs to get medical attention right away. Apply some ice to the area. A doctor may suggest giving a medicine called an antihistamine to control swelling and itching. If you are having a more severe allergic reaction to a fire ant sting, he or she may give you a shot that fights the reaction. People who know that they are allergic to fire ant stings also sometimes carry emergency medicine that they can give to themselves to prevent a severe reaction from happening. The best way to avoid getting bitten by fire ants is to keep your shoes on when playing near fire ant mounds. If you come across one, don’t ever poke at it or try to play with it.

2019-04-24T18:52:35Z

https://www.rchsd.org/health-articles/hey-a-fire-ant-stung-me/

How To Make It Through This Season Of Craziness — Love. Heal. Thrive. How do we feel safe in this crazy world we are living in right now? It seems we are all enduring chaos and never-ending challenges about beliefs, statements andcharacter...from every news story to every conversation we have within our own community, depending on which side of the news story we support. The people in the news are being challenged, and we are being challenged, as well. It is horribly exhausting. Isn't it? So where do you think that leaves us spiritually and energetically? Same place. Exhausted. Where can we find refuge and security from it all? There is a place, and we're going to talk about it today. It is in this place where we feel safe within ourselves, this place where we accept ourselves, this space where we exhale and trust we are exactly where we are meant to be and we are who we are meant to be. It is when we are in this place, feeling secure, that our outside world begins to feel more accepting, safe and authentic too. Our internal world defines our external world. But we must feel it inside first. Acceptance, security, safety- they're all inside jobs. When we can sit in this space created within us and feel God's presence, knowing He has placed you in this blessing, predicament, challenge or triumph to grow you, prepare you and ready you for what your next step will be, then your outside world begins to feel safer and more secure. You will feel accepted by the world around you because you trust the world within you. It is about Divine acceptance and belonging. You are the only person who can do you. God created you perfectly, with all your talents and flaws, to be imperfectly perfect you. There are no mistakes. Just mistaken identities. Sometimes we become so attached to the person we think we're supposed to be that we aren't willing to admire the beautiful, amazing person God created you to be, with flaws and fortitude. Everything begins with trusting what's on the inside first. Go to that place within you, the center of your heart or the deepest part of you and connect to this place where you feel safe and secure. Imagine building a fortress around you, if you must. But find that place of comfort and security. Find that place of exhale, and breathe it out. Breathe insecurity, acceptance and the knowingness you are exactly where you are meant to be. Perhaps you're in a season of triumph, or perhaps a season of trial- trust you are in the season you are meant to be in and remember that seasons change. It will not last forever. However, the wisdom from this season will never expire. That wisdom is gifted to you to be used to help another across the threshold of their season. But it all begins within you first. Take that moment to connect to that place within you and allow that perfectly imperfect person to emerge and begin to bless every life it crosses. I can't wait to hear how you are using your seasons, gifts and flaws to help others! Be sure to share it with us on Facebook and Instagram.

2019-04-24T12:24:32Z

https://www.lovehealthrive.com/weeklyloveletter/2018/10/2/how-to-make-it-through-this-season-of-craziness

The chair was received faulty, but they sent someone out today and took the part to repair and return it tomorrow. As soon as I called they assured me someone would be out to take care of it, and they did. The customer service was great.

2019-04-22T00:18:34Z

https://homestars.com/companies/205321-elte/reviews/361469

You are able to have confidence in True Basement Flooring to deliver the top solutions for Basement Flooring in Minturn, ME. We've got a crew of professional contractors and the most resourceful technologies around to supply just what you need. We make sure that you get the best support, the best price tag, and the best quality supplies. Call us today at 888-272-2812 to begin. At True Basement Flooring, we understand that you must keep within your budget and spend less anywhere you are able to. Yet, saving cash shouldn't ever mean that you sacrifice quality with Basement Flooring in Minturn, ME. We provide you with the finest quality even while costing you less. We use the very best practices and supplies to guarantee that your venture can face up to the test of time, and conserve your funds in ways that won't modify the quality of the work. We can make this happen by delivering the very best deals around and eliminating costly blunders. If you wish to find great deals, True Basement Flooring is the business to call. Our company is waiting to accept your phone call at 888-272-2812. Basement Flooring are available in Minturn, ME. Concerning Basement Flooring in Minturn, ME, you need to be informed to come up with the most effective choices. We will never inspire you to come up with poor judgments, as we understand exactly what we are undertaking, and we make sure you know very well what to look forward to from the task. We will take the unexpected situations from the equation through providing adequate and complete info. The first step will be to give us a call by dialing 888-272-2812 to begin your job. We'll go over your concerns once you call us and get you set up with an appointment. Our company will arrive at the scheduled time with all the required equipment, and will work closely with you through the entire job. Lots of reasons can be found to pick True Basement Flooring for Basement Flooring in Minturn, ME. Our equipment are of the highest quality, our cash saving techniques are practical and efficient, and our customer support scores are unsurpassed. Our company has the experience that you need to fulfill all your goals and objectives. Call 888-272-2812 whenever you need Basement Flooring in Minturn, and we will work together with you to successfully accomplish your task.

2019-04-20T23:04:36Z

https://www.truebasementflooring.com/me/basement-flooring-in-minturn/

Adventure is the raison d'être of Basecamp; that exhilarating feeling of freedom that grabs you when you push your limits and explore new paths. Whether you are looking for a few hours or a few days away, we have what you need to satisfy your dreams of escape. Our fleet is ready to go for gravel riding and bikepacking.

2019-04-20T14:38:08Z

https://www.base-camp.bike/en/blogs/adventure-bikes/

Outlook (and also lots of Various other Email Objectives). This is horrible. Help? Hotmail Help is ready to fix allconcerns relating to the incorrect functioning of your e-mail. Please assist me out. 6. Click Proceed. Postbox will certainly then instantly exercise your server settings. Under is an outline of the required fields to fill out if automated configuration is simply not sustained by your application. FAQ getting going Just how do I sign up with a Gmail, Microsoft Expectation, or Hotmail e-mail account to the myMail application? When you might have Two-Step Verification allowed for your Microsoft account, you’ll wish to use a particular App Password as a replacement of utilizing your personal password. The majority of the information could be embeded in the principle “Include New Email Account” dialog however for either account you’ll also intend to modify even more exceptional settings by pushing the “Much more Setups …” switch. Update: In a new assertion, Microsoft pledges to undergo a much more stringent course of when it needs to fracture open a non-employee’s Hotmail/Outlook account. The fact that Gmail individuals are added “technology savvy” indicates generally they are going to drive a harder deal. Digital Dope discovered Gmail customers are mainly metropolis dwellers. If you typically aren’t specific exactly what setups are called for, examine together with your IT employees or ISP. Did you recognize that you could validate whether your Microsoft account was hacked by someone else? Microsoft have simply recently prolonged Hotmail to make sure that you should utilize The Grid 2 to entrance your Hotmail account. They are a lot less more probable to continue with the very same insurance policy coverage provider/financial institution/utility company/phone solution, as well as much more seemingly to utilize comparability websites. There are great deals of measurements to electronic mail optimization, as well as leveraging mail box supplier info to include additional shade to your customer profiles can cause significant efficiency boosts! Microsoft Overview is currently the main e mail company for any kind of e-mail address ending in “@hotmail. com”, so you’ll use Outlook to reset any type of Hotmail, Live, and/or Overview passwords. Tip one is to confirm that the FBL deal with is authorized to obtain the email. Initially, enter you email address and also tap Succeeding. Once you quit the behavior that activated the blacklist addition, Hotmail will generally eliminate your IP deal with robotically. 3. You could be then redirected to a web page the area it will certainly ask you concerning your e mail id as well as cellphone quantity. You are after that asked to enter your cell number. Hotmail supplies net based support for senders that are having issues providing to Hotmail. MSN Hotmail additionally flaunts nice security options, particularly in the event you access it from a public terminal, and it will perhaps block distant images in e-mails not from secure senders to secure your privateness. GMail supplies access through IMAP and also POP3 nonetheless if you want to make use of POP3, you could first enable this. In other words, you still wish to utilize your primary account which is @outlook. com account so as so that you could access your alias. One other superb news is that, if somebody already used your much-loved ID at @hotmail. com, as an example, you can however utilize the same ID with various domains. For initial “synching” I advice approach (b) to make use of. Must you try it to ahead the e-mail to a non-Hotmail account it will not be approved. I send them and incoming e-mails dealt with to hotmail see to furthermore dissappear? Gmail has actually beaten Hotmail within the fight with lots of impressive attributes. Within the left panel, under your Hotmail account determine, click on on Web server Setups. Select your Hotmail account from the checklist on the. The harmful information is that when you haven’t used your Hotmail account in any type of respect for greater compared to 270 days then Microsoft’s terms and problems permit it to make the account non-active – and also it might be erased altogether. FAQ getting began Just how do I join a Gmail, Microsoft Overview, or Hotmail e-mail account to the myMail app? Most of the data might be set in the principle “Include New Email Account” dialog nonetheless for either account you’ll also desire to change more exceptional settings by pressing the “More Settings …” button. Microsoft have simply recently extended Hotmail so that you must use The Grid 2 to entrance your Hotmail account. Within the left panel, underneath your Hotmail account identify, click on on Web server Settings. The unhealthy information is that when you have not used your Hotmail account in any kind of respect for higher compared to 270 days after that Microsoft’s terms https://outlookguidelines.wordpress.com/2018/03/30/some-hotmail-features-that-youre-not-aware-of as well as problems allow it to make the account non-active – and it could be https://microsoftbuilders.weebly.com/blog removed altogether.

2019-04-21T12:08:48Z

http://somewhereovertheteapot.com/2018/05/16/outlook-and-also-lots-of-various-other-email-objectives/

Based on the traditional marine hardware, with hand braided cord. Hand carved master, lost wax cast in Rhode Island. The sister clasp will naturally hang in the front. This kind of mechanism is also referred to as a gangent hook, kissing clip, or brummel hook. When I was a kid my father first showed me how to make them using bolt cutters and chain links. The sides pass through each other when the slots are lined up precisely perpendicular to each other. It takes a little practice at first, and soon becomes natural. The cord is 16 strands, braided in house using a kumihimo loom. I knot it to the clasp using staggered Matthew Walker knots with whipped ends. The dark and white cord options are braided from nylon twine which I hand wax in house. The dark is hand dyed prior to waxing, and fades very slightly over time. The white cord will fade to grey with wear, based on your lifestyle. The tarred option is braided using nylon twine that is treated with tar for the maritime industry. Like raw denim, the tarred cord will bleed somewhat during the first week or two of wear, and the high spots of the braids texture will fade over time. All color options will stretch a bit over time. 18” circumference including clasps. If you would like a different length (up to 24”) please leave a note at checkout. Longer lengths available, please contact me prior to ordering to discuss. Color images to come. Please note, this item is made to order. A six to eight week delivery time is to be expected.

2019-04-24T20:06:45Z

https://cat-bates.com/products/cn2h

Olive Oil (olea europaea) is desirable in soap as it is anexcellent moisturizer. It attracts external moisture and holds it to the skin, helping to prevent loss of internal moisture. In addition to being a natural, hypoallergenic way to moisturize skin, olive oil has the added advantage of providing strong antioxidants, like Vitamins A and E that help repair and renew skin that has been damaged from overexposure to sun, air pollution, and other modern-day environmental hazards – like cigarette smoke and fast food. These antioxidants have the natural ability to stimulate cells and return skin to a firmer, smoother, and healthier state. Olive oil makes a wonderful soap and salve addition.

2019-04-22T23:04:39Z

http://www.natural.ca/fr/ingredient/olive-oil

Morgan Graham, Christine Lonergan, and former ACGS parent Elizabeth Bouinatchova have started a collaboration to create a new early education movement, inspired by Morgan and Christine's original ideas: An inclusive community with child-led learning and dedicated, creative educators. The plan is to incorporate as a new 501(3)C non-profit. More details to be posted here soon. Christine's new Facebook page: Real School Inc. Schools are not factories. Children are not robots. "Real" school is life, and real learning is play. Christine's blog: what is progressive early education all about? The Format: We intend to start as a workshop / summer / after school program, 1-3 days per week, around July of 2018. Morgan and Christine will host some sessions at their homes in Eagle Rock. Elizabeth may host additional ones at her Los Angeles residence (a kid-friendly enclosed courtyard building in the Carthay/WeHo area). Other suggested locations are welcome! We'll be doing a mixed age group, approximately age 2 to age 6, and we're extending invitations to about 6-8 children in this first round. The Teachers: We plan to engage the 35+ years of teaching and credentials offered by Christine herself, as well her son David who is a certified early education teacher. Morgan will of course chip in as host. Additional caregivers include Karen Sanz, a 20+ year childcare veteran and Pepperdine Art Major, and Elizabeth Bouinatchova, a mom with decades of experience in the Performing Arts, who is also a state-employed safety supervisor for her two special needs children. We're collaborating with several gifted child therapists from Beautiful Minds Center for Autism - we're spectrum-friendly - and other artistic guest-caregivers. ​It's an exciting line-up so far! The Ideas: We want to encourage children's natural energy and creativity with open indoor-outdoor play and free access to music-making accessories, costumes, and props. Christine's guitar will make regular appearances. Elizabeth's creative movement background will likely come into play often, as kids will be prompted to explore characters and themes through pretend play and movement. In more restful times, kids will be offered creative artistic projects with varied materials that will build on other themes they've explored that day. Writing and numbers practice can always be incorporated for students who are interested: We have ideas about exploring the culture and style behind different types of writing and counting. Specifics on all this are available on request. Update: Playgroups have started! Click here for locations.

2019-04-19T17:03:33Z

http://www.realschoolinc.com/ideas.html

Around this time of the liturgical year our focus turns to the birth of Jesus: God entering into the world with all its beauty and all its mess. The Baby Jesus isn’t up to doing much yet, but God is very much at work in the lives of all sorts of people around him. Sometimes they cooperate with God’s grace and sometimes they don’t. We can find ourselves in them. Jesuit Media Initiatives and the Diocese of Westminster Marriage and Family Life team have joined forces to produce a series of imaginative contemplations to help families journey alongside the Holy Family in prayer this Advent. The series of six imaginative contemplations, plus an introduction, will be available to listen to or download from the Jesuits’ spirituality website Pathways to God , from 22nd November. Each contemplation focusses on a person or group from the Nativity story – Mary, Joseph, the shepherds and the Magi - who will all be very familiar to children. Each session will have its own suggested storyline and you are invited to imagine and reflect along with it.

2019-04-20T00:50:47Z

http://jesuit.org.uk/print/7328

View all stories from this issue. Hot flushes, night sweats and painful joints can be a sign that breast cancer drugs are working, a new study suggests. Aspirin does not reduce the risk of heart attack or stroke for patients who have diabetes but no previous cardiovascular disease, a new study reports. Taking part in music-based activities, such as playing handheld instruments or singing action songs, can help children with cancer to cope better, suggests a small US study. A&E nurses who contract viral infections should be sent home at the first sign of illness and not return to work until they are symptom free for 48hours, say Scottish researchers. The number of terminally ill people able to die at home has more than doubled under a new palliative care scheme piloted by a cancer charity.The Marie Curie Delivering Choice Programme, piloted in Boston, Lincolnshire, has seen the number of patients dying at home increase from 17% to 42% since the scheme was implemented in 2004.

2019-04-24T12:55:45Z

https://www.nursingtimes.net/13-november-2007/89.issue?cmd=ChangeSortOrder&amp;val=3

Affordable and convenient holiday flights take off from your departure country, "USA". From May 2019 to September 2019, Condor flights to your dream destination will be roughly 2 a week! Book your Pittsburgh (PIT) - Birmingham (BHX) flight now, and look forward to your "United Kingdom" destination!

2019-04-20T03:11:45Z

https://www.condor.com/us/flights/united-kingdom/birmingham/from-pittsburgh/

Thanks to the efforts of the Minnesota Disability Law Center (MDLC), and a possible lawsuit, the Saint Paul city council voted last month to bring curb ramps up to federal ADA standards. Approximately 230 ramps need to be retrofitted, having been passed over when the city embarked on a major street repair project beginning in 2013. Steven Schmidt, staff attorney with MDLC, said clients became concerned when they noticed that as the work progressed on the St. Paul streets, “the city was not doing any work to the curb ramps.” Read the full Pioneer Press article.

2019-04-23T08:57:12Z

http://www.mnlegalservices.org/legal-services-in-the-news/2016/2/24/st-paul-complies-with-ada-standards-thanks-to-minnesota-disability-law-center

They say, when you have guests coming over, to bake something delicious to make the place smell amazing and, well, to spoil them with. Make these! 1. TO MAKE YOUR STRUSSEL. in your mixing bowl, combine your flour, dark brown sugar, cinnamon and butter together. Use your fork, or hands, to press your mixture down and break it up until you have an even sand-like texture. 2. TO MAKE YOUR MUFFIN BATTER. preheat your over to 350º. In your stand mixer, mix together your flour, white sugar, baking soda, baking powder, cinnamon, and salt. Add in your beaten eggs, butter, vegetable oil and sour cream. Mix on a medium-high speed until you have an even batter. 3. TO MAKE YOUR COFFEE CAKE MUFFINS. spray the cups of your muffin pan with your cooking spray. Fill your cups a quarter of the way up with your muffin batter (this will use about half of your batter). Lightly sprinkle half of your strussel over your muffins. Divide the rest of your muffin batter over your muffins. Add your coconut and mini chocolate kisses to your remaining strussel mixture and then spread it evenly over your muffins.

2019-04-23T14:09:56Z

https://www.coffeeandchampagne.com/recipes/chocolate-chip-coconut-coffee-cake-muffins

How to reach: Bus line 176 from Ravenna / Cervia / Milano Marittima. € 4 off regular adult ticket price, not available on Mirabilandia Beach ticket.. How to reach: Bus lines 176 - 201 from Ravenna / Cervia / Milano Marittima. € 2 off regular adult ticket price. How to reach: Bus line 70 from Ravenna FS dir. Fornace Zarattini, bus stop Piazza Baracca. € 1 off on ticket price. How to reach: Bus line 176 from Ravenna FS dir. Cervia + Bus line 7/RA (SAC) from Cervia FS. 20% off on each thermal pool entrance. How to reach: Bus line 11, walks the entire waterfront. € 2.00 discount on the full admission ticket upon presentation of the ROMAGNA BUS PASS title. VALID FOR THE 2018 SEASON. Can not be combined with other ongoing initiatives.. How to reach: bus line 4 from Ravenna FS, bus line 176 from Cervia, bus stop Motel Romea. How to reach: bus lines 1-3-4-5-8-70-80, bus stop Piazza Caduti, 100 mts. on foot. How to reach: bus line 134 from Forlì FS, or bus line 92 from Forlì FS or Cesena FS to Forlimpopoli, then line 121 or 122 up to Fratta Terme. 12% off on minimum of 3 nights of overnight on the Spa and wellness center or cosmetics products. How to reach: bus line 138 from Cesena Punto Bus. 12% off on minimum of 3 nights of overnight on the Spa and wellness center or on cosmetics products. How to reach: bus line 5, bus stop "Piazza del Popolo". € 3 off on full Fortezza Malatestiana tour. How to reach: bus line 5, bus stop "Papa"(in front of Biblioteca). € 4 off on ticket price. How to reach: bus line 124 from Rimini FS, bus stop Viale Lazio. 20% off on workshops + 20% off on catalogues. How to reach: bus line 11 from Rimini FS, Marina Centro, Bellariva, Marebello, Miramare or bus line 58 from Coriano, S. Andrea in Bes., Riccione Paese or bus line 125 from Cattolica, Portoverde, Misano Mare. 20% off on services with fee inside the gallery + 20% off on catalogues. How to reach: bus line 94 from Cesena or bus line 126 from Forlì. How to reach: bus line 11 from Rimini FS or bus line 125 from Cattolica Autostazione. Sconto 10% su ingresso adulto intera giornata (stagione 2018: dal 2/6/2018 al 9/9/2018).. Come arrivare: il collegamento da Rimini (Linea 160 Start Romagna + Linea 102 Valmabus) è assicurato nei giorni feriali con sette corse di andata e sette di ritorno tutte in coincidenza a Pietracuta. Sconto 2,00 euro su biglietto intero. Come arrivare: Linea 125, partenza da Riccione P.le Curiel / Riccione Terme / Misano Mare / Cattolica FS. Come arrivare: Linea 58 da Riccione mare / Riccione FS. Come arrivare: Linee 9 / 90 partenza da Rimini Stazione FS, Linea 95 partenza da Bellaria Cagnona (Linea 9 direzione Santarcangelo, non utilizzare 9 A; Linea 95 corse ad orario saltuario). Sconto del 50% su biglietto “intero” e sconto del 50% su biglietto “cumulativo famiglie”. Nelle giornate di ingresso gratuito al Museo (Domenica) sconto del 50% sulle pubblicazioni IMC in vendita. Come arrivare:Dalla Stazione FS di Rimini Linea 20, poi 15 minuti a piedi. Prezzo scontato, biglietto € 5 (anzichè € 7). How to reach: Bus line 11 - bus stop n. 34 departing from Rimini Railway Station and Riccione p.le Curiel. 10% off on Spa services. How to reach: Bus line: all bus city lines and extra-urban lines. Bus stop: Rimini Centro/Rimini Railway Station, 350 m by foot from museum. € 2 off on regular ticket price and € 1 off on reduced ticket for Museo della Città. Come arrivare: Line 9 Rimini from Railway Station (dir. Losanna / Airport), Line 11 Rimini from Marina Centro / Riccione P.le Curiel. € 2,00 off from regular ticket.

2019-04-20T04:46:11Z

https://www.startromagna.it/titoli-e-tariffe/convenzioni/

what a great blog...I am so busy with this new job I can't even think about dinner, much less whats in. Yeah yeah I know , I am turning into one of those people that I hate. But I am keeping true to my heart....MONEY will not RULE me. I WILL RULE IT !!

2019-04-19T18:34:47Z

http://www.susieharrisblog.com/2008/04/whats-in.html

Issue Only » Letter on Environmental Rights from Mari Margill, Associate Director, Community Environmental Legal Defense Fund. I had the pleasure to speak at your 2015 convention in Delray Beach. A key focus of the convention was global warming and what the League of Women Voters of Florida can do to stop it. Much of this discussion focused on fracking. While shale – or so-called “natural” – gas is touted as a cleaner fuel than oil or coal, fracking for shale gas has been found to be a major global warming polluter. Florida’s legislature spent time this spring debating a bill to further regulate fracking. Indeed, environmental regulations for fracking sound like a good idea, but what do they actually do? In short, they allow fracking. When we “regulate” an activity – whether it be fracking or otherwise – it means we’re allowing it, in fact legalizing it. Regulations may put certain conditions on an activity – such as setbacks or noise controls – but as communities across the country are learning, even when we better regulate shale gas drilling, we’re still getting fracked. How can this be? Because our environmental laws regulate the use of nature. Thus, under the federal Clean Water Act, coal corporations are authorized to blow the tops off of mountains. The New Hampshire Groundwater Protection Act authorizes corporations to siphon off hundreds of thousands of gallons of water a day from local aquifers to bottle and sell. Similarly, under state oil and gas laws – including Florida’s – corporations are issued permits to drill wells through our aquifers to frack for oil and gas. Communities and groups across the U.S. are coming to an understanding of how our environmental laws actually work, and further, how these laws are part of our broader legal structure which protects fracking, mining, etc., and the actors who conduct these activities. This larger structure of law – i.e., our constitutional structure – is aimed at constant growth, extraction, and development, rather than the protection of the environment or sustainability. To protect that constant growth, the Constitution has been used to clothe corporations in “rights” – to insulate them from anything that may “interfere” with the endless expansion of their operations. As well, our state and federal government have been granted broad “preemption” authority, which similarly is wielded over communities, activists, and groups – to shield the existing system from attempts to change it. Corporate “rights” – along with preemption and other core legal doctrines – form a structure of law that protects endless growth at the cost of people, communities, and nature. It’s a structure that is inherently unsustainable. Communities, beginning in Pennsylvania and now in Ohio, New Hampshire, Maine, Oregon, Washington, New Mexico, Colorado, and other states, are recognizing that if we continue working within the current legal framework – which elevates the right of corporations to frack, drill, mine, etc., over the rights of communities and nature to not be fracked, drilled, etc. – we’ll get fracked, drilled, and mined. That is, if we continue to try to stop individual harms like fracking, and don’t address the basic structure of law which legalizes those harms and ensures the endless extraction and exploitation of nature – then we’ll never be able to protect the environment, stop global warming, or achieve anything close to sustainability. CELDF has partnered with nearly 200 communities across the country to begin to build a new framework – based on the rights of communities and nature to health and well-being – which necessarily addresses those key legal doctrines that communities and activists confront when they try to stop fracking or other threats – including corporate “rights” and preemption. They are doing this by advancing Community Bills of Rights laws which establish rights of human and natural communities. This includes a community’s right to self-govern, the human right to a healthy environment, and the rights of nature itself to exist and thrive. Fracking and other activities which would violate those rights are prohibited. Communities are thus putting in place a new legal framework which for the first time legalizes sustainability. Many are advancing this through their local elected bodies, and others through the local citizens’ initiative process (which also exists in many Florida communities).

2019-04-20T15:04:37Z

https://www.lwvfl.org/letter-environmental-rights-mari-margill-associate-director-community-environmental-legal-defense-fund/

As you may have noticed, I've been radio silent for the last several weeks as I tried to balance some much needed R&R with a boat-ton of work that I had to do for my passion project. All of this and all of you are my passion project, in case you were wondering - and it’s what keeps me inspired and motivated. But now that summer is over, it is time to get back into the rhythm. So here’s what I got going on…. Labor Day has come to pass and with it marks the anniversary of my mother’s death. This is of course a somber time for me, but I also treasure it and hold it dear, in her honor. The reason I mention this, in what is essentially a career blog, is because I always attribute her death as a driving force behind my success. I admit that the years following her passing were an extremely brutal way to start my adult life, but hovering at rock bottom really only provided me with one direction in which to proceed – UP! Somewhere in the depths of despair, I found strength and resolve and a will to strive. I always say that I am who I am today because of my mom's death, as it was the one single event that changed every aspect of my life. This one is mine, but I leave this with you as food for thought as you reflect on your own life. Tonight I am attending an options trading class to brush up on some hedging strategies for my personal trading account. As you know the market has seen a straight shot up since the election, which is great but it also leaves us exposed, should it all fall to pieces. Putting on some hedges in order to protect against downside risk seems like a good idea to me, but I am no expert and want to learn more. As I prepare for this class, I have been looking at my own portfolio and am pondering the following: buy NKE on the dip?

2019-04-21T00:37:33Z

https://tamaralashchyk.com/blog-social/2018/9/6/cool-things

Marion Chiropractic Centre offers our patient form(s) online so they can be completed it in the convenience of your own home or office. For more information or to schedule an appointment with our Winnipeg chiropractor, call (204) 615 0230 today! Drs Michael deJong, Gerald Chartier, Jeff Seney are chiropractors serving Winnipeg and the surrounding area. Our chiropractors and the rest of the welcoming team at Marion Chiropractic Centre are committed to providing chiropractic solutions to address your unique needs, whether you are experiencing back pain, neck pain, headaches, or even muscular tightness and tension. You may be searching for pain relief after an accident, experiencing an injury, or if you suffer from a specific condition like chronic back pain or a spinal condition. Even if you're looking to improve your overall health, our chiropractor can help you attain your everyday wellness goals! Visit our testimonials page to find out what our patients are saying about our Winnipeg chiropractor and our chiropractic care plans. At your first visit to Marion Chiropractic Centre, We will explain how chiropractic care works and give you a full evaluation to see if our chiropractic solutions are a good fit to address your needs. If there is a good fit, we can customize a plan of chiropractic care for your condition and health goals. If you have not been to a chiropractor before and want to find out more, please Email Us or call (204) 615 0230 to receive the answers to your questions from our experienced team. We also welcome referrals, so we invite you to share our chiropractic and wellness information with your friends and loved ones. "Fabulous! All 3 Doctors strive to give the best care to their patients! I feel very comfortable and safe every time I have an adjustment. The reception staff is also wonderful and super friendly! Wouldn’t want to go anywhere else!"

2019-04-20T21:38:18Z

http://www.marionchiropractic.ca/?newsletters=32022

Sitting atop the cliffs of Dana Point, Elizabeth & Eric prepared to tie the knot at the Laguna Cliffs Marriott Resort and Spa. With a beautiful oceanfront view, Elizabeth and Eric's ceremony looked stunning - especially with the beautiful flower arrangements from Nisie Enchanted Florist. Another very sentimental addition to this wedding ceremony was what laid above Elizabeth and Eric for the duration of the ceremony. Elizabeth's father had passed away, so to honor his memory they were married beneath his tallit. There were many of these sentimental touches throughout the day to keep his memory close to Elizabeth and Eric as they began their new life together. Nathan Prince, along with Jessica Wolfe, captured this special day with the assistance of Zack and Frank. Everyone on the team had a wonderful time filming this very fun, laid back, and friendly couple. Mazel tov! Elizabeth & Eric's full Hora!

2019-04-26T00:15:20Z

https://www.princeweddings.net/blog/2015/08/22/laguna-cliffs-marriott-wedding-video-elizabeth-eric

Machinery & Assembly alignment kit - Checks straightness, flatness, squareness & other geometries. When your company is looking for the Swiss Army Knife of laser alignment kits but your latest project requires a focus on dual axis precision alignment, the Microgage 2D Universal Linear Kit steps up. Use this measurement kit for positioning machine guides and checking rail parallelism in the blink of an eye. Similar to the Universal Kit, the 2D Universal Linear Alignment Kit allows for highly versatile ways to collect alignment data. With enhanced software and a user-friendly interface, the Universal Linear Kit makes learning the system simple. The customizable alignment accessories and the 4-Axis Precision Mount streamline the alignment process and increase the quality and volume of alignment data recorded. In addition, the Universal Linear Kit comes with the 90-Line Right Angle increasing your team’s ability to capture precise parallelism, perpendicularity and squareness. Checking for runout on rotors and shafts or for surface planer has never been so intuitive.

2019-04-21T06:53:58Z

https://pinpointlaser.com/products/microgage-2d/kits/universal-linear/

Used Carbatec - Second [2nd] Hand Carbatec Equipment for sale Australia. Machines4u and its private sellers and dealers have 7 Carbatec machines for sale. All new Carbatec machines incorporate the latest technology to make the design and user experience even more enjoyable. On the other hand, there are used Carbatec equipment in all sizes and configuration to meet your needs and standards. If you are looking for more information about a certain machine you can proceed to that specific advertisement. There, you will find full contact details of the dealer or private seller so you can contact them directly for further inquiries. CARBATEC Dust Hose Connector - 4" CARBATEC Dust Y-Junction - 2-1/2" CARBATEC Dust Y-Junction - 5" CARBATEC Wood Thread Box - 3/4" CARBATEC Wood Thread Box - 1/2" CARBATEC Wood Thread Box - 1"

2019-04-24T22:02:49Z

https://www.machines4u.com.au/brand/carbatec/Used/

The Spy camera is a covert device that records the footage at the real time without alerting others.Since the spy gadget is small, compact and therefore it can be concealed anywhere and can be carried also and that is why the Spy camera in Ghaziabad and other prominent cities is in high demand.The spy devices like spy pen, button,teddy,camera are a look like of the respective objects and so the person can easily use it anywhere he feels like.The gadgets not only save the audio and video, but can also transmit it further.The wide range of the Spy Camera in India is available at online and offline spy stores. The hidden cameras come handy as some of the security camera like CCTV can be implanted in the office and home as well.The interested people can buy Security Equipments in India from the reliable manufacturers, dealers,traders of the spy gadget also.The covert camera is not restricted to indoors only, the same device can be used for sting operations too, as it can record good quality videos, even in the dark also, so it can be a great medium to expose the truth. The different types of spy products available in Ghaziabad India are wireless camera, audio device, spy gadgets, spy software, and etc. We also provide jassosi cameras in bulk to the investigation bureau, news channels reputed factories and companies.We also cater for customized requirements and wholesale services as we are are wholesalers and retailers also.The spy cams which are in great demand these days are Keychain Camera, Photo Frame Camera And Button Cameras In Ghaziabad India.We assure best Spy Gadgets in Ghaziabad India. You can either by spy cam online or from spy shops and stores. Our main showroom is located in Ghaziabad and our help lines are open 24/7 so make the best use of it.

2019-04-21T21:00:41Z

http://www.spysort.com/spy-camera-in-ghaziabad.html

OtherWorld, a pilot news experiment, has recently been launched on the streets of Manchester in the UK, providing citizens a new means by which to access local news and engage more interactively with their city. Launched by startup studio Like No Other and Google’s Digital News Initiative, OtherWorld uses varied technology, including Bluetooth and beacon technology to connect people to geo-located news via their smartphone while they are out and about on city streets. Described as “living media”, OtherWorld news is delivered directly to devices without needing to install an app. Location based stories and news alerts are instantly shared with people as they navigate the city. A silent notification will appear on phone screens as they pass a story location. The notification disappears when the pedestrian moves out of range, marking the relevance of the location and the time of the event in direct relation to the user. They then choose whether or not they wish to engage with the information. OtherWorld offers urbanites a new perspective through which to view their city. By revealing the layers of the environment around them, the environment is brought into focus and opportunities are provided for deeper exploration of familiar surroundings. By focusing on events that are directly related to the immediate environment, users are offered the opportunity to engage with a nearby prospect, become aware of a volunteer opportunity or a public meeting they would otherwise not have been aware of, which in turn gives them the chance to involve themselves more actively in the public realm. Though accessible to everyone, OtherWorld has been developed with the younger audience in mind. As more traditional means of accessing news media no longer engage the younger generation, it is hoped that this more geo-located method will help to re-engage this specific audience. OtherWorld also believes their system is a chance to provide access to major news coverage to those who traditionally aren’t given a voice, mainly independent businesses, to highlight the role they play in a local community environment. “In an era that is seeing a rapid decline in both traditional newspapers and news websites - with most people relying instead on the crowdsourced curation of news via social media - what OtherWorld does is create an ultra-personal ‘homepage’ based entirely on where you are and what you’re doing at that moment, practically guaranteeing its relevance to your life and interests. Users move through their surroundings to discover stories and, in so doing, reinvest in their cities and communities,” says Megan Fowler of ArchDaily.

2019-04-20T02:22:31Z

https://www.outdoordesign.com.au/news-info/a-sign-of-the-times/5474.htm

I want to be able to take an image and blur it relatively quickly (say in 0.1 sec). Image size would almost never be larger than 256 x 256 px. Do I have to loop thru every pixel and average them with neighbors or is there a higher-level way that I could do this? PS: I am aware that multiple box blurs can approximate a gaussian blur. This rasterizes the view down to 4x4 pixel chunks then scales it back up using bilinear filtering... it's EXTREMELY fast and looks ok if you are just wanting to blur a background view under a modal view. To undo it, just set the rasterization scale back to 1.0 or turn off rasterization. Take a look at Apple's GLImageProcessing iPhone sample. It does some blurring, among other things. If you always or at least often use the same blur settings you might gain speed by doing the filtering in frequency domain instead of the spatial domain. The pros of this approach is that pixel-wise multiplication should be pretty fast compared to averaging a neighborhood. So if you process a lot of images this might help. The downside is that I have no idea how fast you can do fourier transforms on the iPhone so this might very well be much slower than other implementations. Other than that I guess since the iPhone has OpenGL support you could maybe use its texturing functions/drawing to do it. Sorry to say though that I am no OpenGL expert and can't really give any practical advice as how that is done. Take the image, a draw it at partial opacity 5 or 6 (or however many you want) times each time offseting by a couple pixels in a different direction. drawing more times in more directions gets you a better blur, but you obviously trade off processing time. This works well if you want a blur with a relatively small radius. For monochromatic images, you can actually use the build in shadow as a simple blur. You might want to take a look at Mario Klingemann's StakBlur algorithm. It's not quite Gaussian, but pretty close. Any algorithm that modifys images on a pixel level via openGL is going to be a tad slow; pixel-by-pixel manipulation on a openGL texture and then update it every frame is sadly performance in-adequate. Spend some time writing a test rig and experimenting with pixel manipulation before committing to implementing a complex blur routine. The very basic of blur (or maybe more of a soften), is to average 2 neighboring pixels and apply the average to both pixels. iterate this throughout the image, and you get a slight blur (soften). Not the answer you're looking for? Browse other questions tagged ios image-processing blur or ask your own question. How can I achieve partially see-through effect in iOS?

2019-04-26T07:07:25Z

https://stackoverflow.com/questions/1140117/how-to-implement-a-box-or-gaussian-blur-on-ios

The Dhoom and Golmaal actress, Rimmi has vanished from the screen these days. Wondering why? The reason is that Rimmi wants to do some different kinds of roles now.The Bengali girl who has not delivered any substantial performance yet, wants to change her image from that of a conventional actress to an unusual and meaningful one. Rimmi wants to work with some different directors such as Sriram Raghvan. The ‘Phir Hera Pheri’ actress is working with Sriram in his upcoming film, ‘Johnny Gaddar’ and in ‘Shagird’ by Tigmanshu Dhulia. So will Rimmi be able to do a make over of her image? Lets wait and watch.

2019-04-21T16:49:48Z

http://www.bollywoodentertainment.com.au/blog/rimmi-waiting-to-make-a-difference/

I love it! Did you just had it done? I am looking for a charm just like this one!

2019-04-22T20:28:52Z

https://thattravelingnurse.com/2017/04/28/a-haiku-on-wanderlust/

The little exposed spine, blanket-stitch book is finished. It is so sweet. How lovely it is to get so much pleasure out of just making a little book! that the whole book at every opening lays perfectly flat. Just lovely...nothing better than a beautiful handmade book. Thanks Fiona, I had intended it to be a bit "softer" to look at than this but I am happt with the mechanics of the book, if you know what I mean. Hi Gemma, have just had a lovely wander around your blog. Love what you do - from the sophisticated calligraphy which is totally enviable to the delight you take in binding a beautiful book. I love this blogging world where the viewer is invited into your art life to take a peek. A treat. Thanks Susie. I must tell you, not long after we settled here we framed those three gorgeous works of yours ... I'll take a pic and post them here so you can see how stunning they look.

2019-04-18T22:53:22Z

http://blog.gemmablack.com/2012/03/little-exposed-spine-book-is-finished.html

I joined MINT in 2006 and work full time as an independent consultant and trainer. I have been fortunate to have designed and facilitated more than twelve hundred MI workshops for health care practitioners, behavioral health clinicians, social workers, psychologists, psychiatrists and criminal / juvenile justice professionals, and I provide training for trainers in evidence-based practices. I serve on a number of MINT committees and have served on TNT teams in Fort Wayne, Atlanta and Berlin. I frequently provide MI coding and skill development coaching, coding QA, research intervention design, and consultation to systems for effective MI implementation. While my official MINT address is in Maryland, I am also regularly based in San Francisco (CA) and Reno (NV). I spent my undergraduate years at Occidental College in Los Angeles, and completed graduate studies in organizational behavior at the School of Industrial and Labor Relations at Cornell University as well as my J.D. at the Cornell University School of Law. In my spare time, I participate in cold- water marathon swimming events, raising funds for under-resourced kids’ charities. For additional information, please see www.alihalltraining.com.

2019-04-22T18:02:26Z

https://motivationalinterviewing.org/profile/alihall

His record suggests he’s unlikely to push pricing policies that would hit pharmaceutical companies’ pocketbooks. President Donald Trump tweeted Monday that his nominee for HHS secretary, Alex Azar will “be a star for … lower drug prices!” But the record of the former top executive for Eli Lilly, which tripled the price of a top-selling insulin drug while he led its U.S. operation, suggests a different story. Lilly is one of three drug companies targeted by a class-action lawsuit that accuses the company, then under Azar’s watch, of exploiting the drug pricing system to ensure higher profit for insulin and has been fined in Mexico for colluding on the pricing of the drug . Azar, who spent almost a decade at Eli Lilly, rising to become president of the drug giant’s U.S. operations before leaving earlier this year, doesn’t deny drug costs are a consumer issue. But his record there and as a top official in George W. Bush’s administration suggests he’s unlikely to push pricing policies that would hit pharmaceutical companies’ pocketbooks. In recent years, Azar has defended pricing practices, and argued against the approaches to reduce costs to consumer s as Trump endorsed during his campaign, such as allowing the government to negotiate drug prices and importing medicines from oversees. Instead, Azar has followed the pharma messaging playbook on drug pricing — deflecting attention to other parts of the health system, and even other countries, blaming them for the high drug costs paid by U.S. patients. He’s also justified drug prices as the cost of innovation. Trump’s focus on drug pricing in announcing Azar’s nomination didn’t win over doubters, who no longer believe he is serious about going after the industry he once slammed as “getting away with murder.” But it will make it easier for critics to pounce on what will likely be the toughest barrier for Azar to overcome during his confirmation process in the Senate. Sen. Bernie Sanders said Monday he will “vigorously oppose” the nomination of Azar. “During Mr. Azar’s tenure at Eli Lilly, this multi billion-dollar corporation dodged taxes while charging Americans outrageously high prices for life saving prescription drugs,” Sanders said. Sanders and Rep. Elijah Cummings commenced an investigation into Eli Lilly’s rising prices for insulin last year, spurring attorneys generals in Washington and New Mexico to look into the matter. The lawmakers questioned why the prices of the diabetes medicine whose main patent expired 75 years ago have seen huge jumps in recent years, with competitors often raising prices in tandem. One of Eli Lilly’s insulins, Humulin R U-500, rose 325 percent in price from 2010 to 2015. Cummings tweeted that picking Azar is “like a fox guarding the hen house,” and a “slap in the face,” to Americans waiting for action on lower drug prices. Azar contends the outrage over drug pricing “erupted because we have seen a complete fundamental restructuring of health insurance,” with a shift to high-deductible plans that puts the burden of drug costs on employees and individuals, he said at a conference in May. While Azar makes a valid point, changing insurance policies without addressing drugmakers’ markups of existing drug prices, or high launch prices for new medicines, “is avoiding the elephant in the room.” said Ameet Sarpatwari, who studies drug prices at Harvard Medical School. Even Azar acknowledged in his speech that if insurance companies reduced consumers’ out of pocket charges for medicines, those costs would show up elsewhere, likely in premium increases. Azar has also attacked government regulators and payers for devaluing pharmaceutical innovation, suggesting that if the U.S. cuts pharma profits, it will see decreased investment in new drugs and fewer new cures. “The narrow focus of costs of medicine to the exclusion of innovation would be self-defeating in the long run,” Azar said in a 2014 speech. Sarpatwari worries such views will lead Azar to promote the idea that making it quicker and easier for drug makers to introduce new medicines will reduce pharmaceutical costs. Researchers have found that drug companies don’t price their products any cheaper when FDA lets them use the accelerated approval process or other tactics to speed drugs to market. Former FDA Commissioner Robert Califf recently said that despite claims by the Trump administration that faster drug approvals lead to lower cost drugs, there is no direction relationship between the cost of development and price of drugs. Nonetheless, in June, Azar told Fox Business that getting more new drugs to market to increase competition among brands would help bring U.S. prices down. Yet there’s only one example the drug industry can point to in the U.S. where brand competition has led to lower prices — and many where competitors simply raise prices in tandem. For example, Democrats recently launched a probe into the rising price of multiple sclerosis drugs where drugs introduced decades ago have raised prices to match their newer competitors. And while Azar expresses support for competition, one of the major factors keeping generic versions of insulin off the market have been drug company tactics known as evergreening — making incremental tweaks to their insulin versions or the devices that deliver it, to extend their monopolies for decades. An article published in The Lancet in late 2015 found that most of the recent innovation in the insulin market has centered on improvements in delivery devices, blocking generics by agents that are indirectly related to the drug. Azar has also opposed other ideas to encourage competitive drug pricing. He’s spoken out against studies known as comparative effectiveness research, used to determine which drugs are most cost-effective for treating patients with a disease. He argues that all options should be available since different patients may need different medicines. The problem however, is that if payers must make all drugs available, they have little leverage to negotiate lower drug prices with industry. The result is that despite Trump’s tweets praising Azar as a champion for lower costs , few fighting for lower drug prices are pinning their hopes on action by Azar. “This nominee has impeccable big pharma credentials but non-existent credentials when it comes to concerns on drug prices,” said Peter Welch, co-chair of the House Democrats Drug Pricing Task Force.

2019-04-23T12:02:26Z

https://www.politico.com/story/2017/11/14/alex-azar-eli-lilly-drug-prices-244888

The Supreme Court helped protect property rights yesterday by deciding unanimously that Mike and Chantell Sackett can legally challenge the EPA’s demand that they cease work on building their new home. The Pacific Legal Foundation (PLF), which represented the Sacketts, announced the victory. A Reason TV video summarizes the case. After the Sacketts purchased property near Priest Lake in Idaho for the purpose of building a home, the EPA declared that they could not build because the government had designated their property a “wetland.” Further, after the EPA ordered the Sacketts to stop work and threatened them with severe fines if they continued, the EPA declared that its threat could not be challenged in court. This is a great day for Mike and Chantell Sackett, because it confirms that EPA can’t deny them access to justice. EPA can’t repeal the Sacketts’ fundamental right to their day in court. And for that reason, it is a great day for all Americans, for all property owners, and for the rule of law. . . . EPA can’t try to micromanage people and their property—it can’t order property owners to dance like marionettes—while denying them any meaningful right to appeal to the courts. It can’t threaten property owners with financial ruin and not have to justify its threats to a judge. And it can’t issue lazy, drive-by ‘wetlands’ edicts about private property. It will have to put in some honest work and use credible science, because the regulators must be able to justify their wetlands orders in a court of law. Kudos to PLF and the Sacketts for their victory and to the Supreme Court for stopping this particular assault by the EPA. However, the fundamental problem is not that the government improperly identified the Sacketts’ land as a “wetland,” nor that the EPA might have violated property rights without judicial review, but rather that the EPA and the government are able to violate property rights at all. As the Reason TV video points out, the EPA acted against the Sacketts on the authority of the 1972 Clean Water Act, which (among other things) effectively nationalized any property that the government declares a “wetland.” But property owners have a moral right—and properly a legal right—to drain their land of putrid swamps and other so-called “wetlands” if they want, or to preserve or create ponds or other water features as they see fit. What owners do with their property is properly none of the government’s business (unless property owners somehow violate the rights of property owners downstream or the like). While the Supreme Court’s decision is a victory for property owners, it is only a small step in the right direction. Anyone concerned with protecting property rights must embrace as his ultimate goal the elimination of all rights-violating government policies and actions, including all those of the EPA.

2019-04-22T19:01:07Z

https://www.theobjectivestandard.com/2012/03/supreme-court-properly-slaps-down-epas-assault-on-property-owners-but/

Compare the Huawei Pronto and LG UX565 below. We pit the Huawei Pronto vs LG UX565 so that you can see which device matches your needs. Compare specs, features, reviews, pricing, manufacturer, display, color, camera, battery life, plans available, and more to see which is better for you.

2019-04-22T03:03:45Z

https://www.wirefly.com/compare/lg-ux565-vs-huawei-pronto

Welcome Kids Quest Alumni, Campers and Parents. You will find this part of the website dedicated to the thousands of people who have shown us support over the years on the Potter's Ranch Facebook Page, but we also have a special Facebook page privately setup just for YOU. Login to your account, it is visible on your account page. If you haven't already, you should sign-up for our Kids Quest Newsletter, learn about any upcoming Alumni Camps and view some great Historical Photos. There is also an opportunity to give others the experience you remember here. Potter's Ranch has a Scholarship Program that gives a helping hand to those who would benefit from camp but cannot otherwise afford it. This program helps many campers attend every summer. Please help them continue to do this by donating to the cause. Help us improve our program and facilities by donating to our Annual Campaign. Help a child in need come to camp by donating to our Scholarship Fund. Donate your physical goods directly to camp.

2019-04-19T08:52:03Z

http://quest.pottersranch.org/connect/families.php

The team had a great evening out on Friday 21st September to celebrate Bill having been in business for 65 years. We are all proud of Bill’s achievements, having started the business back in April 1953 and 65 years later we are still going strong. During this time we have seen massive changes in the legal, business and tax environment and we have supported our clients successfully through these changes for over six decades. Andrew (Bill’s son) began working in the family business over 28 years ago and is looking forward to being of service to the business community for many years to come. Our traditional values, embracing modern technology, have served us well in the past and we look forward to helping our clients with future challenges such as Making Tax Digital.

2019-04-24T20:08:21Z

https://gwdickandco.co.uk/congratulations-on-your-achievements-bill/

The London Silver Company.Com are the exclusive suppliers to England Rugby for the creation of the England Rugby Rose Silver Collection. Handmade in sterling silver these they represent the official England Rugby Rose emblem. Laura Wright the mezzo soprano is the official singer of the national anthem at Twickenham for all games. She is also an ambassador for the official England Rugby Silver Rose collection. These England Rugby Cufflinks are secured to your cuff with a solid silver rugby ball by a chain link. These England Rugby Silver Rose Cufflinks are created by hand and the petals are painted with enamel by a cocktail stick. They are then highly polished by craftsmen to create the sparkling effect that only silver can give you. Perfect for your everyday work shirt or for that pre Rugby World Cup 2015 black tie dinner, the England Rugby Cufflinks are the Dogs. If you prefer a simple T-Bar to fix your links then these England Rugby Cufflinks in sterling silver might be the links for you. All of our cufflinks come gift boxed and carry the official England Rugby logo and hologram for total authenticity. Other pieces to compliment your England Rugby Cufflinks from the Silver Rose Collection include a Tie Slide. Tie slides are back in fashion with the Hollywood glitterati such as George Clooney & Leonardo DiCaprio wearing Tie slides to black tie events.

2019-04-21T22:57:55Z

http://www.thelondonsilvercompany.com/blog/england-rugby-cufflinks/

This exciting Blues Brothers Tribute can come as a 2 peice show or with up to a 7 piece band performing a high energy stage show. Totally exciting and family friendly! The band enjoys playing immediately recognizable rock 'n' roll dance tunes from the 60's. Some of the groups covered by The Touchables include The Beatles, The Rolling Stones, The Kingsmen, Elvis and Buddy Holly. The Wanted hails from South Texas. We are a classic rock cover band fronted by a female vocalist, We cover all the great classics from the 70s, 80s, 90s and todays hits. We also perform tributes from many classic bands and a special tribute to women of rock. Established original hard rock / metal band. -5 SINGERS AND BAND DURING A VARIETY OF R&B AND BLUES. PERFORMING HITS FROM THEIR TWO CD'S "IT MUST BE LOVE" A CAMMY AWARD WINNER OF YEAR 2000, AND THEIR NEWEST CD "LOVE FEELING"

2019-04-25T08:29:26Z

https://www.gigroster.com/listings/search?page=7&query=Pop+or+Rock+Bands

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2019-04-21T10:16:21Z

http://pardon.eu/viewtopic/titles-wallflower-of-being-perks-a-essay

Aside from the concept reveal at E3 2016, we haven’t heard much about Scorpio from Xbox. The project is happening, it’s the most powerful home console ever and it’s coming in 2017. That’s the bulk of it, without drilling into specifics. A fan reached out to Head of Xbox Phil Spencer on Twitter about Scorpio. Phil Spencer, being who he is, took time to respond. I'm in a day long review of where the team is on Scorpio right now, amazing progress and we are feeling good about schedule. I don’t mean to incite a console war here. That’s not much intention. I will say that between Sony and Microsoft, the latter has been the better listener. Microsoft introduced the Xbox One as a media center with high TV priority. Fans responded, and Microsoft pivoted. Fans complained about the dashboard, Microsoft issued month after month of updates. Fans asked for features, Microsoft responded. Fans want a much more powerful Xbox One, Microsoft’s giving them that with Scorpio. If it’s making amazing progress, that excites me as a consumer. It excites me more than the PS4 Pro, that’s for sure.

2019-04-21T01:21:48Z

https://www.technobuffalo.com/xbox-scorpio-is-making-amazing-progress-says-xboxs-phil-spencer

The foreign ministry says allegations that it was involved in breaking into U.S. government computers and stealing millions of workers' records are "irresponsible" and "unscientific." AP's Erika Kinetz reports that Italian authorities discovered that more than $4.9 billion had been smuggled out of Italy to China using a money-transfer service. At the nation's second-busiest airport in Chicago, delays have been even more common than in the five years before a new runway opened, an AP analysis finds. Disaster teams righted the capsized Eastern Star river cruiser to ease the search for more than 340 people still missing. So far, 97 bodies have been found. Jeb Bush is stepping into the Republican race for president, finally taking his place amid an unwieldy field of GOP candidates unlike any in recent memory. The U.S. government will issue the May jobs report, which could reveal what might drive U.S. economic growth over the next year. Some families are installing in-home water recycling systems so that shower water can be later be used in the garden. FDA says the twice-rejected "female Viagra" pill is approvable but with safety measures. Two friends of Boston Marathon bomber Dzhokhar Tsarnaev are scheduled to be sentenced at separate hearings for impeding the investigation. Stephen Curry had 26 points and eight assists, and Golden State holds off LeBron James and the Cleveland Cavaliers for a thrilling 108-100 overtime victory.

2019-04-26T01:55:41Z

http://theind.com/article-21108-10-Things-to-Know-Today.html

The 2018 Annual Conference was held on October 24 - 25, 2018 in Granbury, TX. Justices of the Peace and Justice Court Clerks received 8-hours of education on Setting Bail, Mental Health Assessments, Civil Scenarios, and Eviction Scenarios taught by the Texas Justice Court Training Center. Constables and Deputy Constables received the required TCOLE 8-hour Court Security Officer training. Our deepest condolences go out to the family and friends of retired Tarrant County Constable, and Past JPCA President, Zane G. Hilger. Constable Hilger began his career with Tarrant County in 1983 as a Deputy Constable. He was appointed Constable for Precinct 3 in 1986 and remained in that position for twenty-six years until his retirement in 2012. Visitation was held on Tuesday, August 7th and deputies escorted Constable Hilger to the Center of Unity church in Grapevine. Internment followed at 901 Bourland Road, Bourland Cemetery in Keller. An association meeting to discuss business updates and the results of of the annual audit of association accounts was held at 10:00 a.m. on June 26 following the General Session at JPCA's Annual Conference in College Station. On April 23 - 26, 2018, members met in Nacogdoches, TX for an intensive 3-day training class addressing the issues of Trauma Affected Veterans. Judges, Constables, Clerks, and Deputies took a 3-day training class to find out how to deal with trauma affected veterans. The North Texas Justices of the Peace and Constables Association held its annual conference on November 1st and 2nd at the Best Western Hotel in Greenville, Texas. Join us next year for more fellowship and education! Jena Prescott, Associate Transportation Researcher, from Texas A&M University shares data on fatal car crashes across Texas.

2019-04-24T03:57:56Z

https://www.ntjpca.org/events

Central Florida Animal Reserve News | Central Florida Animal Reserve | Compassion. Conservation. Commitment. Happy Anniversary to Central Florida Animal Reserve! – We Smashed it!

2019-04-20T10:33:39Z

https://cflar.org/cfar-news/page/2/

Aspect Chamber Music Concert Series was established to introduce and promote a novel concert format, "Music in Context," which gives our audiences an opportunity to discover new aspects of music. All our concerts combine refined programming with inspiring talks by world-renowned speakers and musicians, transforming a traditionally auditory experience into a fusion of various art forms. Our concerts start at 7:30pm, but we warmly invite you to join us at 7:00pm to enjoy a complimentary glass of wine and socialize with fellow music-lovers at our pre-concert receptions. The impulse to create this foundation came from the musicians I was fortunate enough to encounter – musicians who were not only excellent artists, but true intellectuals. Their profound knowledge of every aspect of the music they perform has significantly deepened my own perception of it. The concept of ‘Music in Context’ seemed perfectly harmonious: musicians who are willing to share their skills, vision and knowledge are given a forum to do so; members of the audience, eager to nurture their minds and souls, are given an opportunity to experience music in a particular artistic context and to hear the insights of those intimately familiar with it. Our concept is continuously evolving. Whether we inquire into the composer’s mindset at the time of the music’s creation or investigate the mysteries of his or her creative process; whether we delve into the history of the music and into the spirit of its time or explore the literary, philosophical or historical influences on the music, we always endeavour to set the context for each musical piece. We strive to enable the audience to decipher the meaning of the music, and to find an individual connection with it. If you are enthusiastic about our approach to music and programming, if you are excited about our concept and our wonderful performers, then please become our friend and supporter and enable us to bring you more of our captivating and enriching events. By becoming our friend and supporter, you will be a part of our concert series and your contribution will be greatly appreciated, regardless of the amount. If you share our passion for music and arts, join us and help us continue to bring together exceptional artists and speakers who in turn will bring to you the unique experience of ‘Music in Context’. To give us your support, please email irina@aspectfoundation.net. To become part of our loyal audience, please sign up using the ‘Join our mailing list’ form below so that we can keep you informed about our upcoming events.

2019-04-22T22:34:16Z

https://www.aspectfoundation.net/about-us

Education beats the beauty and the youth Picture Quotes was posted in August 25 2018 at 9:28 am and has been seen by 9 users. If you want to view image in full size just click image on gallery bellow. Education is the best friend An educated person is respected The Beauty Of Youth Quotes Quotes Design Ideas What you want to worship above youth I think is beauty and beauty Youth Beauty Quotes Sayings Youth Beauty Picture Quotes Mathew Henry Quote Flower of Youth ChristianQuotes Inspiring Short Youth Quotes and Sayings The Smartest Cute Short Education beats the beauty and the youth Picture Quotes Chanakya Power Quotes QuoteHD Democritus quote The pride of youth is in strength and beauty the The ability to see Quotes Pinterest Youth Wisdom and Thoughts The Beauty Of Youth Quotes.

2019-04-21T20:34:08Z

https://homebedroombathroom.com/the-beauty-of-youth-quotes/education-beats-the-beauty-and-the-youth-picture-quotes

Incredibly, we are able to harness the sun’s unending energy. There are a lot of ways to achieve this, like photovoltaic cells or solar panels. They can heat your water and supply electricity. When we use fossil fuels to create our power we besides bring about greenhouse gases that are unbelievably harmful to our environment, causing contamination and deep harm. They are running out, are unreliable and they are very pricey. Another asset of solar energy is that it is unique when compared with fossil fuel made electricity as it can be installed and adapted even in the most removed place. It is good for our environment as it is soundless, non-polluting and clean. The solitary premise is that it faces in the right direction, otherwise you can put it wherever you want to on your property. Once the solar panels or photovoltaic cells are installed you can leave them alone because there are no moving parts that require care, which is a incentive. You can take away or add solar panels according to you wants. When you move house, you can undo them and take them with you. You are more autonomous and self-sufficient when you choose solar energy, which means that you don’t have to rely on the utility companies, no matter where you live. Solar energy can be generated in a few various ways so look up ahead of time since it can be pricey to set up in the beginning. Examples are: fixed panel, which is a stationary mechanism and is the least expensive; a mechanism that tracks the sun by moving horizontally or vertically is the single axis, which is the mid-priced selection, and the dual axis which is able to track the sun in many ways, with the downside being that it is costly. By selecting solar energy generation, you can take to be off grid, where you are not linked to the utility electricity grid. A diesel generator is best for this situation as a back up energy source. Alternatively, you can be tied to the grid and be connected to the utility electricity grid with the gain of being able to sell any excess electricity back to the grid. At first glace the cost of installation could be prohibitive and is a key component in the decision-making process upon whether to use solar energy or not. Not great news, notably in today’s economic climate. By selling extra back to the grid after you have taken what you require, you can clear your money inside five years. Go to your local authority energy efficiency office to find out whether there are grants going and/or go on a course to find out how to put in solar electricity yourself to save on costs. In addition, a helpful practice is to find out whether you want planning permission to fit solar panels to your roof or preferred location because the last thing you require is to take it down! Do your exploration into what is the better option for you and your circumstances. There are choices out there and you do not need to pay thousands of pounds to have solar energy generation in your house.

2019-04-26T01:48:22Z

http://www.wisedir.com/useful-information-about-solar-electricity-generation

Barkley Dress by Les Prairies de Paris. Long sleeved, wool crepe tunic dress with front pockets & suede trim. Split neckline / Snap button closures at front placket with suede tab detail / Long sleeves / Single chest pocket with suede trim / Curved front yoke with diagonal slit pockets / Relaxed, straight fit / Color: Noir / 78% Viscose, 22% Wool.

2019-04-25T18:31:56Z

https://lagarconne.com/products/dlpbrkfw11-les-prairies-de-paris-barkley-dress

Would you like to be more attuned to your own experiencing and to those you live and work with? Would you like to learn an embodied and relational approach to unwinding stress and trauma? Focusing is a process of inward bodily listening that allows for healing the most painful wounds and discovering our unique gifts. Focusing-Oriented Therapy is a body centered and relational process that helps therapists keep clients safe and regulated while unwinding chronically stuck and traumatic experiences. In this two day workshop, I will teach you the basic steps of Focusing so you can practice with a partner and bring Focusing into your life and healing practice. You will gain access to the rich inner wisdom that unfolds as you find Presence in your own life, and then how to facilitate a Focusing-Oriented approach to healing with others. After completing the first workshop, you can continue your learning through more workshops to complete the first year of the program. These workshops will help you expand your skills, deepen your experience, and ground your practice of Focusing. The goal of these workshops is to help you build a solid foundation of Focusing skills and experience so you can bring this unique skill set into your practice with others. I look forward to sharing this journey of self discovery and transformational healing with you! FOT-1: $345.00 for early or $395 for standard registration. FOT-2 through 5: $395.00 for registration when paying for individual workshops. All workshops are approved for 12 continuing education units. All mindfulness and focusing skills are practiced during the workshops so you can learn experientially. Each workshop comes with a manual, supporting materials for your learning and a recommended reading list. You will learn how to incorporate these exciting new Focusing skills in your personal life and your professional practice. Focusing partnerships form during each workshop as a way of practicing and deepening your experience and skill building. After you have completed the five Focusing workshops, you are eligible to take my Focusing for Complex Trauma Training. What Makes This Focusing Training Unique? This Focusing training is not your typical continuing education for healing professionals! Instead of teaching you a technique to do to someone, Focusing training reveals a naturally occurring, innately powerful, self-healing process. Learning Focusing is psychological and philosophical, and touches spiritual edges as it takes you deep into your own experiencing. A core value of this training is developing you – the healing professional – and how you incorporate your personal Focusing process into your healing practice with others. Throughout this workshop series, you will continually ground your experience in a widening sense of your authenticity. You will become attuned to your body’s way of communicating your personal truth about situations. Diving further into your own experiencing, a new understanding of what is meant by the body emerges, a situational body as experienced from the inside, interacting with its environment. With this Focusing training and practice through partner exchanges, you will discover your own experiencing process, how it gets blocked, and how Focusing can continually illuminate the path to your own healing and growth. With a little time and experience you will gain clarity about how to integrate Focusing into your life and work. For healing professionals who want to use Focusing in their work, ongoing support and learning is available on an individual basis and in small learning groups. Feel free to contact me with questions.

2019-04-19T21:06:11Z

https://morrisontherapy.com/focusing-training-program/year-one/

Whether you’re installing vinyl windows or looking for replacement vinyl windows, if you’re in the Cooksville, MD area, you’ve come to the right place. Quality Window & Door is one of the largest window suppliers and installers in the Baltimore-Washington metro area. We carry top-quality vinyl windows from a variety of leading manufacturers, and our installation process and conscientious customer service make installing vinyl windows in Cooksville, MD easier than ever! Vinyl windows are an excellent choice for Cooksville, MD area homeowners. With exceptional performance, low maintenance, longevity, and affordable cost, vinyl windows have become one of the most popular choices for homeowners and builders in the Cooksville, MD area. Affordability – vinyl windows are relatively inexpensive to manufacture, making them the affordable window choice for homeowners in Cooksville, MD. Call us today to learn more about installing vinyl windows in Cooksville, MD. If you are considering installing vinyl windows in Cooksville, MD, contact Quality Window & Door today. Our window experts are highly trained and have years of experience recommending vinyl windows to home and business owners. Schedule a no-obligation in-home consultation to learn more about our vinyl window selection and let our window professionals help you pick the vinyl windows that are best suited for your home and budget. Call us today or fill out the contact form to the right to learn more about installing vinyl windows in Cooksville, MD.

2019-04-23T10:42:46Z

https://www.qualitywindowanddoorinc.com/vinyl-windows-in-cooksville-md

The Center for Fertility and Gynecology specializes in treatments to help you start the family you've always wanted. With a variety of treatment options and therapies available, our team can design a plan to help you get pregnant. When you visit us for an IVF treatment, ask our physicians about assisted hatching, or micromanipulation. Performed while the embryo is in the laboratory, assisted hatching is a procedure designed to thin the outer layer of the embryo, allowing it to break out or "hatch" more easily to increase the chances of pregnancy in some women. Generally used for women whose eggs have a thicker shell and have been unsuccessful with standard IVF, assisted hatching may improve your chances of pregnancy. After the embryo has been in the lab for three days, a weak acid, or microlaser is used to thin out or create a hole in the embryo's outer layer. After being carefully cleaned, the embryo is placed back into the womb. Because the protective layer of the embryo will be affected, we often use antibiotics to prevent infection in the mother. Some of the patients at our Los Angeles fertility center have experienced higher pregnancy rates after the performance of assisted hatching. Studies show that older women tend to have a thickened zona pellucida (the outer layer of the embryo) and therefore benefit from this procedure. After many failed IVF treatments, a woman's embryo may lack sufficient energy to "hatch" naturally, making Los Angeles assisted hatching a viable treatment option. Research suggests that assisted hatching is no more likely to cause complications or abnormalities than traditional IVF. Because only the outer layer is changed, the embryo remains intact and unharmed. Approximately 1 percent of embryos are damaged during treatment, but the treatment is often avoided when only one embryo is available. As with each of our fertility treatments, we are committed to providing a comprehensive examination and consultation to ensure that assisted hatching will be safe and as effective as possible for you and your family. This appointment allows you to become informed and prepared for the treatment and gives you a chance to address your questions and concerns. For our patients in Los Angeles, IVF and assisted hatching can improve your chance of a successful pregnancy. If you think you may be a candidate for assisted hatching and want to learn more about this revolutionary procedure, we urge you to contact the Center for Fertility and Gynecology today. Dr. Vermesh and his team of fertility experts can work with you to organize a plan that will give you and your partner a chance to build the family of your dreams.

2019-04-23T00:05:19Z

https://www.center4fertility.com/blog/2012/11/15/assisted-hatching-116492

Seeing a therapist does not mean that something is wrong with you, or that you must be going through a crisis or an emergency. Going to therapy can be about strengthening skills so that when a situation occurs, you are better equipped to handle it. Individuals and families participating in therapy may experience many benefits, such as: improved mental and emotional health, more positive relationships, increased self-esteem, improved communication, more effective stress management skills, and better problem-solving skills, etc. It is quite possible that some clients may only need a few sessions to see improvements. However, since each person and life situation is different, positive change may occur at a different pace for each client. Choosing a therapist to best meet your needs is an important decision. Listed below are the services that I offer, as well as some of the areas that I specialize in. Please contact me to schedule a free, brief phone consultation to discuss your counseling needs and set up your first visit. To find out more, call me at (561) 289-2810, or click below to set up a consultation call.

2019-04-23T17:55:57Z

http://www.naguiatlmhc.com/therapy-services/

Have you been putting off adding a social media review plugin to your website? Have you been wondering what’s all the fuss with online reviews? Do you really need them you wonder? The answer is that your business stands to gain so much from collecting reviews from your customers and, believe or not, whether good or bad, reviews are a huge help to your business. Collecting social media reviews gives you impressed customers who will be interested in your products or services and this translates to more referrals and increased website traffic. A survey by BrightLocal found out that 88% of customers consider online reviews to be trustworthy. Still not convinced? Let’s take a quick look at the benefits of collecting online customer reviews for your business. Every review that you receive from a happy customer and is posted on your website is a form of advertising for your brand. Online reviews expose your products/services to online users increasing your brand awareness. Online reviews are very cheap to collect and unlike other forms of advertising, even the smallest of businesses can afford to collect online reviews. The more people post feedback on your website the more exposure you get while spending very little on advertising. There is huge power in testimonials. As happy customers talk about why they love your product/service they get to impress potential customers giving you a better chance of turning them into real customers. Web visitors who read your online reviews have a 58% higher chance of buying your product/service. Research shows that your average order value will increase by 3% every time shoppers read online reviews. Online reviews influence how well you perform in search engine results page. Google, for instance, takes note of every time your business name is mentioned online. The more reviews you have, the more mentions you will receive and the higher you will rank on Google. According to AdWeek, 800 words of review text performs as well as 70 percent of new web content, which search engines reward with higher search results. Besides showcasing the quality of your products/services, online reviews will also let you showcase your brand’s personality. A response to a review is as important as the review itself. Responding to online reviews, whether they are good or bad, gives you the chance to show your personality to the public. Make a point of always addressing any complaints lodged and thanking those who leave you positive reviews. This shows that you care about your customers. Peer recommendations have become a big thing in the social media era, and are equivalent to word of mouth referrals. People trust brand recommendations from their friends and family more than they trust adverts. Whenever people leave a review using your social media reviews plugin they also get the opportunity to share that review with other people on various social media platforms such as Facebook, Twitter, etc. Every review that recommends your brand is a powerful marketing tool for you that stands to convert someone into a customer. Online reviews build trust in your brand. The more people see other happy customers, they start trusting you and want to be part of the fun. Even bad reviews reassure potential customers that you’re actually a genuine brand. The truth is that no matter how good you are at what you do you will never ever please anyone so it’s natural to have a few bad reviews. You only worry when you have more negative reviews than positive ones. Consumers are today more interested in authenticity over perfection. Therefore, having both good and bad reviews will encourage people to interact with your brand and encourage shopper confidence. Online reviews give you the opportunity to build relationships with your customers. A person may not buy your product immediately after reading your review but at least you now have their attention. You can then work on building the relationship from there and eventually convert them into customers using other marketing efforts such as email marketing. The manner in which you reply to all reviews will also determine the kind of relationship you build with your customers and potential customers. Responses to online reviews allow you to give a human touch to your brand. Remember, consumers, want to engage with a human and not a company. The benefits of online reviews are undeniable. I believe that you’re now fully convinced why you should start collecting online reviews already. The easiest way to collect and publish online reviews is a good social media review plugin. A plugin will give you greater control of your reviews. You can build your own review page, collect testimonials and star ratings as well as display reviews on your website product pages. We highly recommend the Rateky social media reviews plugin for WordPress or Joomla website owners. The plugin lets you automatically import customer reviews from Facebook, Twitter, Instagram, Zendesk and more and display them on your site. The Rateky plugin comes with a customizable business page that you can use to display all your reviews at one place as you receive them. Your website visitors also get the chance to like and flag your reviews from the business page giving your reviews more power to influence potential customers. The plugin allows you to import reviews from your Facebook business page, your Twitter mentions as well as Zendesk Satisfaction rating. You can then display them on your website’s business page. This plugin allows you to review all reviews and you get to decide which ones to approve for display on your website. You can also add custom posts by your customers and fans and display them on your business page. Your customers have a very easy way to access your site and leave you a review. Instead of registering using an email, they can easily authenticate their identity using either their Twitter or Facebook accounts to add reviews on your website. This helps you get genuine entries and also keeps your website safe from spam reviews. The Rateky social media reviews plugin integrates seamlessly with both WordPress or Joomla sites. It will let you publish reviews on your website using WordPress and Joomla plugins. The plugin comes with Zapier integration that lets you connect to over 750 automation apps such as Trello, Wunderlist, whmcs, among others. This lets you automate the flow of your reviews. Step 1: Import your existing reviews: Installing and setting up the plugin is super easy and once you’re done you can start importing your Facebook reviews, Twitter mentions, Instagram tags, Google Place reviews, and Zendesk ratings. Your reviews from all over the internet will now be available in one place giving them more exposure. Step 2. Create new reviews: After automating existing reviews you can go on to set up new review submissions. You can create a special invite link that you can send to your customers inviting them to leave comments on your business page. Step 3: Monitor and review submissions: Once new reviews start streaming in or after you have imported your existing reviews, you can select the ones that you want to display on your website as not all reviews will be meaningful or helpful to your business. Step 4: Display your reviews: The final step is to display the submissions that you have approved on your business page. Once your reviews are displayed on your website or the custom business page, web visitors will now be able to see them. Rateky social media reviews plugin is currently available for $14.99 only for a limited time. This limited deal comes with a coupon code redeemable for 1-year of Rateky Premium Plan. You can publish unlimited reviews on your website with this plugin for a single website and you get free support from the Rateky staff. Sounds like a good deal right? Grab it today before the deal runs out! Your customers are your number one fans and they are also a huge marketing opportunity for your business. Don’t let the chance to get free publicity pass you by. If you haven’t started doing it yet, you better get those online reviews starting today. The best part is that you don’t need to do much, simply ask your customers to leave you a review and the Rateky social media reviews plugin will do the rest!

2019-04-22T15:56:05Z

https://wpnewsify.com/plugins/social-media-reviews-plugin/

John Connor: I knew it. I knew it was coming. But this is not the future my mother warned me about. And in this future, I don't know if we can win this war. This is John Connor. Reese's introduction isn't the only thing that stays the same about the character between movies. Here he uses his preferred weapon - a sawed-off shotgun. Marcus isn't keen on having a gun aimed at him though, so he snatches it out of Reese's hands, then teaches him a trick to keep that from happening - fashioning a safety strap. Reese puts that same trick to use after he steals a police shotgun in The Terminator.

2019-04-19T22:14:04Z

https://www.moviemistakes.com/film7524

Why does no one teach this stuff? This is the comment I hear from every second coaching client I have ever worked with. The principles of smart money management are so simple, yet here in Australia, 1 in 2 people aged 18- 35 experience financial stress of some kind on a weekly basis…. Yes, you heard it right – 1 in 2 people experience financial stress on a weekly basis. We live in one of the wealthiest countries on earth, yet our younger generations are failing to thrive, financially weighed down by unrealistic lifestyle expectations and consumer debt. As of this month, my 3 beautiful kids are now all teenagers! And yes, I am going both bald and grey – but that’s another story! Both my girls have had lessons on basic budgeting in year 9 maths and commerce but to them it was just another topic to be learned, like calculus or trigonometry. Without any practical real-life application, these lessons were useless. Money management skills need to be ‘lived’ not simply taught in a classroom. So, parents, like it or not, it is up to you and I to teach our children the money skills they need to thrive as adults. It is our responsibility an no one else’s … Scary huh! Even scarier is the fact that they are already learning from you, oh yes, they are watching you like a hawk and in the absence of purposeful education they will just copy you. So – think for a minute – what lessons do you think you are subconsciously teaching your children right now? Do you give them money every day to buy their lunches and go out with their friends? Do all your purchases go on the credit card? Do they ask for (and receive) expensive presents every birthday and Christmas? Do you eat out or get takeaway a lot? Do you pay for them to have their hair coloured and styled? Do you buy them designer clothes? What are the lessons and lifestyle expectations that come from these actions? Do you think your children will be able to afford to buy lunch and coffees every day, eat out regularly, give extravagant presents, get their hair coloured and styled and buy designer clothes when they first start working? No, of course not, yet that is the lifestyle they have grown accustomed to and unless you teach them otherwise, they will almost certainly drive themselves into the financial ditch trying to maintain that lifestyle when they are left to their own devices. As a budget coach, I see young couples and individuals every week who seemingly have it all, and yet they have nothing. They are up to their eyeballs in debt and struggling to keep their head above water. No one taught them about the dangers of credit cards; they just did what their parents did and put everything on the credit card. I don’t have the heart to tell them they should take it up with their parents! One of the most satisfying aspects of being a budget coach is helping my clients pass on what they have learnt to their children. Teaching your children about money does not have to be scary or difficult. So, let me ask you Mum and Dad, now that you understand that it is your responsibility to teach your cherubs about money, what steps are you going to take to make sure it happens? Okay – so it can be a little hard to get started. If teaching your kids about money is a scary proposition, then can I encourage you to click on the link below and register your interest in attending one of our Free ‘Money Smart Kids’ Live Webinars.

2019-04-20T06:59:16Z

https://www.grandmasjars.com/blog/parents-kids-need-teach-money/

Research Passaic Dark Fiber Instantly Online! To obtain Dark Fiber for your business in Passaic County, give us a call at (888) 765-8301 or use our online quote tool (on the left) to get an initial estimate on Dark Fiber in Passaic. Once we receive your information we'll give you a call to discuss your individual request. Why use darkfiberopticnetwork.com for your Online Passaic Research? Our Passaic Dark Fiber tool does the shopping for you. We give an unbiased opinion on Dark Fiber in Passaic County. Select the Passaic County, NJ Dark Fiber price plans that interest you. A Passaic New Jersey Dark Fiber consultant will contact you to discuss the details of the Passaic County Dark Fiber, confirm pricing, and assist you with the signup process.

2019-04-20T06:35:48Z

http://darkfiberopticnetwork.com/dark-fiber-provider-passaic-county-nj

Ship Info Apps Free Download For PC Windows 7/8/10/XP.Ship Info Apps Full Version Download for PC.Descargar Ship Info Apps Latest Version for PC,Ordenador portátil,Windows.Ultimate and one of the largest merchant-ships’ base de datos. More then 300K ships in database! Some of functions are working offline. 3.Open Android Emulator for PC import the Ship Info Apps file from your PC Into Android Emulator to install it. 4.Install Ship Info APPS for PC.Now you can play Ship Info APK on PC.

2019-04-25T22:10:59Z

http://appslatestdownload.com/ship-info.html?lang=es

Steve Barnes Plumbing specialises in home water filtration. Our specialties are ridding your water of problems like water hardness, high iron content, Low Ph, smells caused by gases building up in the water system, arsenic removal, radon removal, nitrate removal and many more common problems. We can handle all water issues.

2019-04-25T08:12:27Z

http://www.stevebarnesplumbing.com.au/services/water-filters

Casey Buscher is currently living the dream in New York attending Syracuse University’s Broadcast & Digital Master’s Program. And let me tell you, she’s a force to be reckoned with! Casey graduated this May with her bachelor’s in electronic media and communications. She has a passion for reporting and sports media, and I’m pretty sure you’ll be seeing this face your TV soon. 🙂 Go rock the sports world, Casey! You’re a beauty inside and out!

2019-04-26T08:03:41Z

https://jenabethmorgan.com/2018/08/29/casey-buscher/

My first frame tent was made by Relum. The model was a Relum Bungalow 4K. set up by one person [with practise - lol]. Sorry that should have been www.jacksons-camping.co.uk I missed off the "s".

2019-04-19T07:12:59Z

https://www.caravanbanter.co.uk/12137-re-recommendations.html

Complete Abandon Super Friends Team Up! Don't Let The Bossman Get You Down! Elvin Bishop & Little Smokey Smothers That's My Partner! George Carlin A Place For My Stuff! Joe Cocker Joe Cocker - Joe Cocker! Borrowed Time- Best Of The Lost Lennon Tapes, Vol. Manfred Mann - Mighty Garvey!

2019-04-19T20:47:46Z

http://scmidnightflyer.com/curmusic.html

On April 18th, 2000, the NYU Annual Survey of American Law dedicated its 57th Volume to former U.S. Senator and former Chairperson of the Peace Negotiations in Northern Ireland Commission George J. Mitchell. Speaking at the dedication in Mitchell's honor were, among others, The Queen's University of Belfast Vice Chancellor George Bain, New York University Professor of Law Norman Dorsen, and attorneys Berl Bernhard and Harold C. Pachios. George Mitchell was appointed to the United States Senate in 1980 to complete the unexpired term of Senator Edmund S. Muskie, who resigned to become Secretary of State. He was elected to a full term in the Senate in 1982. Senator Mitchell went on to an illustrious career spanning 14 years in the Senate. He left the Senate in 1995 as the Senate Majority Leader, a position he had held since January 1989. For six consecutive years he was voted "the most respected member" of the Senate by a bipartisan group of senior congressional aides. Recently, Senator Mitchell served as Chairman of the Peace Negotiations in Northern Ireland. Under his leadership an historic accord, ending decades of conflict, was agreed upon by the governments of Ireland and the United Kingdom and the political parties of Northern Ireland. In May 1998, the agreement was overwhelmingly endorsed by the voters of Ireland, North and South, in a referendum. While in the Senate, Senator Mitchell served on the Finance, Veterans Affairs, and Environment and Public Works Committees. Senator Mitchell additionally led the successful 1990 reauthorization of the Clean Air Act, including new controls on acid rain toxins. He was the author of the first national oil spill prevention and clean up law. Other achievements while in the Senate include leading the Senate to passage of the nation's first child care bill, being the principal author of the low incomeousing tax credit program, being instrumental in the passage of the Americans with Disabilities Act, landmark legislation extending civil rights protections to the disabled. George Mitchell's efforts additionally led to the passage of a higher education bill that expanded opportunities for millions of Americans and leading the Senate in the ratification of the North American Free Trade Agreement and creation of the World Trade Organization. Senator Mitchell received his undergraduate degree from Bowdoin College in 1954, and then served in Berlin, Germany with the Army Intelligence Corps until 1956. He received an LL.B. degree from Georgetown University Law Center in 1960. From 1960 to 1962 he was a trial lawyer in the Justice Department in Washington, D.C. From 1962 to 1965 he served as Executive Assistant to Senator Muskie. In 1965, he returned to Maine where he engaged in the private practice of law in Portland until 1977. He was then appointed U.S. Attorney for Maine, a position he held until 1979, when he was appointed U.S. District Judge for Maine. He resigned that position in 1980 to accept appointment to the U.S. Senate. Senator Mitchell is the author of three books. With his colleague, Senator Bill Cohen of Maine, he wrote Men of Zeal, describing the Iran-Contra investigation. In 1990, Senator Mitchell wrote his second book, World on Fire, describing the threat of the greenhouse effect on recommending steps to curb it. His third book, published in 1997, was Not For America Alone: The Triumph of Democracy and The Fall of Communism. In 1999, Senator Mitchell wrote Making Peace, an account ot his experience in Northern Ireland. Upon leaving the Senate, Senator Mitchell joined the Washington, D.C. law firm of Verner, Liipfert, Bernhard, McPherson and Hand.

2019-04-24T01:14:29Z

https://www.law.nyu.edu/journals/annualsurveyofamericanlaw/dedications/georgemitchell

I love this product, it's great for sensitive eyes. Its very creamy and the colour payoff is great. This is the only kohl eyeliner I can find that I love and is affordable. I wear contacts and its hard to find kohl pencils that don't irritate my eyes. Annabelle products are awesome for sensitive eyes and skin. I highly recommend this product.

2019-04-26T03:49:34Z

https://www.annabelle.com/en_ca/kohl-eyeliner-34

The story of the first privateer and his adventures; including the account of Alexander Selkirk's living alone on an island off Chile which formed the background to Robinson Crusoe. . . .brugh will not be permitted to go off, and there will be extravagant Reprisals made upon our Estates and Persons, which we expect you will take into your Consideration: and we cannot omit to let you know, that there is now a Spanish Bark actually in England, which is daily expected with other English Ships to load Wine, which they will not be admitted to do, in case you don’t restore this Bark. We don’t doubt but the People here out of Complaisance will make you some acknowledgment of a Refreshment. Gentlemen,Your very humble Servants,J. Pouldon, Vice-Consul, J. Crosse,Bernard Walsh,G. Fitz-Gerald. ‘Pray excuse Haste, that we have not time to transcribe. ‘The rest of the Merchants are in the City where our Governor generally resides, being about six Leagues hence. Wealthy son of a wealthy man takes to the sea to prove something to the parents, presumably. Seeks adventure, finds the limits of his own capacity. Loses everything in the process and then stumbles upon a hell of a story in the process.

2019-04-21T01:00:22Z

https://www.allyoucanbooks.com/ebook/cruising-voyage-around-world-woodes-rogers

Mobile home of the month, for only 14,995€. This fantastic Willerby Cottage is 7.8m x 3.7m, and is a full 2 bedroom, 1 bathroom. It has a centre lounge configuration, making the most of the space, and keeping the bedrooms apart. It is being sold fully furnished, as per the photos. It is sited on a residential site called Maciscava Rustica Park, which is just outside the town of Pinoso. The site has a large communal swimming pool, and terrace area, and the site is pet friendly. To avoid disappointment, an early viewing would be highly recommended. The ground rent on this particular site is only 2,700€ per year, which includes the VAT, all the local taxes, and the community fees. This property has just had 3,000€ worth of decking installed at no extra cost. If you have any questions, please do not hesitate to contact us.

2019-04-24T12:56:34Z

https://www.spain4rent.eu/rs1148-mobile-home-of-the-month-1276.html

The securities litigation law firm of Brower Piven, A Professional Corporation, has commenced an investigation into possible breaches of fiduciary duty and other violations of state law by the Board of Directors of Salix Pharmaceuticals, Ltd. ("Salix" or the "Company") (Nasdaq: SLXP) relating to the proposed buyout of the Company by Valeant Pharmaceuticals International, Inc. ("Valeant"). On February 22, 2015, Salix and Valeant announced the signing of a definitive agreement pursuant to which Valeant will acquire Salix in a transaction valued at approximately $14.5 billion. Under the terms of the transaction, Salix shareholders are anticipated to receive $158.00 in cash for each share of Salix common stock held. The transaction is expected to close, in the second quarter of 2015, though Salix shareholders will most likely be asked to vote on the transaction well before that time. The firm's investigation seeks to determine, among other things, whether the Company's Board of Directors failed to satisfy their duties to shareholders, including whether the Board adequately pursued alternatives to the acquisition and whether the Board obtained the best price possible for the Company's shares of common stock. In particular, according to Yahoo! Finance, at least one Wall Street analyst has issued a price target for Salix stock at $185.00 per share. If you currently own common stock of Salix and would like to learn more about the investigation being conducted by Brower Piven, without cost or obligation to you, please visit our website at http://www.browerpiven.com/currentinvestigations.html. You may also request more information by contacting Brower Piven either by email at hoffman@browerpiven.com or by telephone at (410) 415-6616. Attorneys at Brower Piven have extensive experience in litigating securities and other class action cases and have been advocating for the rights of shareholders since the 1980s.

2019-04-25T04:29:24Z

https://www.thestreet.com/story/13054749/1/shareholder-alert-brower-piven-commences-an-investigation-into-the-proposed-sale-of-salix-pharmaceuticals-ltd-and-encourages-investors-to-contact-the-firm-for-additional-information.html

This adidas Linear Logo T Shirt is a lightweight, regular fit. It is designed with short sleeves and a crew neck. This t shirt is in a block colour design and is complete with a printed adidas logo for instant brand recognition.

2019-04-22T02:02:37Z

http://www.mercerbrotherhood.com/men-clothing/adidas-linear-logo-t-shirt-mens-mens-t-shirt-lightweight-regular-fit-593113-tnssfqu.html

Looking for Lanota Cheats? We have got all the most useful cheat codes for you and all for free. With these Lanota Cheats you can unlock all in-game purchases items and set them to unlimited mode and also unlock all levels and powerups. By using our Lanota Cheats you can use the hidden God Mode in Lanota. Our Lanota mods are the best and easiest method used for hacking Lanota .It is safer than any other Lanota hacks and mods on the web. You don’t need to download any of those sketchy hacktools or mods on your phone anymore since our Lanota Cheat Codes and be entered directly into the cheat console and without any extra tools or apps. Use the cheat console from the link below to use any of our Lanota Cheat codes. Lanota Cheats work on on both Android & Apple iOS Devices. Use Lanota Cheats and Enjoy!

2019-04-25T07:53:51Z

https://ubergamez.com/%F0%9F%91%8D-lanota-cheats-for-android-and-iphone-%F0%9F%91%8D/

The 'Global and Chinese Chemokine Testing Industry, 2013-2023 Market Research Report' is a professional and in-depth study on the current state of the global Chemokine Testing industry with a focus on the Chinese market. The report provides key statistics on the market status of the Chemokine Testing manufacturers and is a valuable source of guidance and direction for companies and individuals interested in the industry.Firstly, the report provides a basic overview of the industry including its definition, applications and manufacturing technology. Then, the report explores the international and Chinese major industry players in detail. In this part, the report presents the company profile, product specifications, capacity, production value, and 2013-2018 market shares for each company. Through the statistical analysis, the report depicts the global and Chinese total market of Chemokine Testing industry including capacity, production, production value, cost/profit, supply/demand and Chinese import/export. The total market is further divided by company, by country, and by application/type for the competitive landscape analysis. The report then estimates 2018-2023 market development trends of Chemokine Testing industry. Analysis of upstream raw materials, downstream demand, and current market dynamics is also carried out. In the end, the report makes some important proposals for a new project of Chemokine Testing Industry before evaluating its feasibility. Overall, the report provides an in-depth insight of 2013-2023 global and Chinese Chemokine Testing industry covering all important parameters.

2019-04-18T15:07:36Z

http://oneresearchreports.com/report/Global-and-Chinese-Chemokine-Testing-Industry,-2018-Market-Research-Report

List of Chicago indie rock bands, listed by popularity with photos when available. This list includes more than just bands, as indie rock solo artists from Chicago are included as well. It's always interesting to see where famous bands got their starts, so use this list to discover some great Chicago music that you've never heard before. The indie rock bands and artists below have played their music all over the world, but they all were formed in Chicago. If you think the best Chicago indie rock band is missing from the list, then feel free to add it at the bottom so it's included with these other great acts. A list made up of bands like Wilco and Andrew Bird. If you want to answer the questions, "Who are popular indie rock bands from Chicago?" and "Which indie rock bands started in Chicago?" then this list will answer your questions.

2019-04-20T20:59:56Z

https://www.ranker.com/list/chicago-indie-rock-bands-list/reference?ref=fact_based&l=2387717

A share room gives you a place to share a folder full of files. They do not need spideroak. Share rooms also allow you to password protect the entire folder. I've written about it here. Share rooms allow you to have a key that even Spideroak does not possess, so the files are as secure as your password. Shared files are the very secure but not quite perfectly secure way to share a single file. The huge advantage is that it is so easy. The files are encrypted on their server and they automatically delete in three days. However, since Spideroak does have the key so they can decrypt the file for the person receiving it, there is a little less perfect security than a share room with an extra password. To put the risk in perspective, I'll be happy if my CPA sends me my taxes using the Spideroak File share. I see no reason for more security. Backup the file you want to share. Click the Link button in the upper right. Wait a bit while Spideroak creates a secret key and uses it to encrypt and save your newly encrypted file to random location on their servers. Large files will take a few minutes to encrypt and save. Right click the newly created link and select all. Then copy it. When your client or friend receives the email, they can just click on the link in it to open or save the file you are sharing. Here is a 3 minute demonstration. To view the demo on YouTube click here.

2019-04-24T16:14:42Z

https://steveshank.com/cgi-bin/article.pl?aid=666

Accovion is a leading European full-service Contract Research Organization. We provide the entire range of clinical research services to the pharmaceutical, biotechnology and medical device industries. Our local expertise in offices across Europe, combined with broad experience, enables us to deliver the support that our clients need – where needed, when needed.

2019-04-24T06:30:07Z

http://www.researchforindustry.ro/site/viewCompany/1446

Why Are Foods Different Colors, Is There a Benefit? August 6, 2011 August 9, 2011 Wallace Bishop I.N.H.C, C.N.C. Every Food Color Has Different Antioxidants, Eat All the Colors!! Why did God create our foods to have different colors? Do you ever think, why are tomatoes red or yellow? Is there something about the color that makes the food special? Yes, the colors do mean something. The different colors identify certain phytonutrients the vegetable or fruit may contain. Their role in plants is to protect plants from disease, injuries, insects, drought, excessive heat, ultraviolet rays, and poisons or pollutants in the air or soil. They form part of the plants immune system. When we eat the plant we get the protective benefits of the plant immune system, also. Scientists do not consider phytonutrients as essential for health although they do provide health building properties. Phytonutrients are essential for optimal health. This means you can live without them, however, your level of health and ability to resist illness or diseases is not at its highest. Phyonutrients are a different class of nutrient. They are not vitamins, minerals, fats, proteins or carbohydrates. Although some Vitamins and Minerals do act as powerful antioxidants, phytonutrients are different and act as antioxidants, providing protection for our bodies in many ways. Antioxidants help prevent aging by protecting our bodies from free radicals. Free radicals damage cell structure and can even damage cellular DNA leading to mutations which may cause cancers and other diseases. If you are an athlete, sick or have a lot of stress in your life, you need greater quantities of antioxidants. These colorful foods also provide a wide assortment of vitamins, minerals, enzymes, fiber, protein, complex carbohydrates, antioxidants and fatty acids. Although low in calories they pack a real nutritional punch feeding your body healing and renewing nutrients. A carpenter can’t build a house without lumber and nails. You can’t build and support a healthy body without the bodies building materials, nutrients. You can build a body out of junk food, however its going to be a junk body that most likely will suffer from many nagging ailments such as; chronic pains, aches, digestive problems, high blood pressure, high cholesterol, blood sugar imbalances, infections, hormonal imbalances, anxiety, depression, mental fog, low energy, fatigue, poor mood, poor memory and eventually disease. What Antioxidants Are Which Color? Contain nutrients such as lycopene, ellagic acid, Quercetin, and Hesperidin, to name a few. These nutrients reduce the risk of prostate cancer, lower blood pressure, reduce tumor growth and LDL cholesterol levels, scavenge harmful free-radicals, and support joint tissue in arthritis cases. I love tomatoes but I also love apples, cherries, strawberries, raspberries, red grapes, cranberries, pomegranates, red currents, red bell pepper and cayenne peppers. Contain nutrients which include lutein, zeaxanthin, resveratrol, vitamin C, fiber, flavonoids, ellagic acid, and quercetin. Similar to the previous nutrients, these nutrients support retinal health, lower LDL cholesterol, boost immune system activity, support healthy digestion, improve calcium and other mineral absorption, fight inflammation, reduce tumor growth, act as an anticarcinogens in the digestive tract, and limit the activity of cancer cells. Certainly blueberries are a favorite of many but also try, purple or black grapes, black berries, black currants, eggplant, purple cabbage, purple onions, purple carrots and purple asparagus. Contain beta-carotene, zeaxanthin, flavonoids, lycopene, potassium, and vitamin C. These nutrients reduce age-related macula degeneration and the risk of prostate cancer, lower LDL cholesterol and blood pressure, promote collagen formation and healthy joints, fight harmful free radicals, encourage alkaline balance, and work with magnesium and calcium to build healthy bones. Common orange and yellow foods are pumpkin, butternut squash, sweet potato, spaghetti squash, oranges, papaya, carrots (carrots can also be found in yellow, and purple) and salmon. Yes, wild caught salmon is rich in beta carotene, that’s why it is bright orange. Farm raised salmon is not nearly as rich in beta carotene and is not as healthy of a choice as wild caught. Green vegetables contain chlorophyll, fiber, lutein, zeaxanthin, calcium, folate, vitamin C, calcium, and Beta-carotene. The nutrients found in these vegetables reduce cancer risks, lower blood pressure and LDL cholesterol levels, normalize digestion time, support retinal health and vision, fight harmful free-radicals, and boost immune system activity. A few green foods you may recognize are avocado, broccoli, spinach, kale, chard, asparagas, cabbage, zucchini, cucumbers, kiwi, limes, romaine, endive, celery, collard greens and brussel sprouts. Contain nutrients such as beta-glucans, EGCG, SDG, and lignans that provide powerful immune boosting activity. These nutrients also activate natural killer B and T cells, reduce the risk of colon, breast, and prostate cancers, and balance hormone levels, reducing the risk of hormone-related cancers. Think bananas, mushrooms, radishes, turnips, potatoes, onions, garlic, shallots, leeks and cauliflower. Brown foods such as chocolate (dark only is best), beans, nuts and seeds provide many different types of phytonutrients such as epicatechin, ellagic acid, isoflavones, resveratrol and many more. Pecans have the highest antioxidant rating of the nut and seed family. Raw cocao (chocolate) has the highest antioxidant rating of any food. Try dark chocolate that is 85% dark or higher, black beans, red beans, pinto beans, lentils, almonds, flax seed (must be ground), walnuts, pecans, peanuts, pumpkin seeds and sunflower seeds. Eat the rainbow everyday if possible. It’s easy if you make a salad. I have a salad almost every day and it is loaded with every color. Making the food rainbow a part of your daily life is going make you and your body happy and healthy!! Children need 5 servings of fruits and vegetables every day, women need 7 and men need 9. Please eat your daily requirement of vegetables, fruits, beans, nuts and seeds. Previous Post Do You Have Chronic Inflammation? Prevent It!

2019-04-23T15:55:27Z

https://wallysdailybites.com/2011/08/06/why-are-foods-different-colors-is-there-a-benefit/?share=google-plus-1