id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
18501
[ "Because", "these", "genes", "play", "a", "positive", "role", "in", "cell", "proliferation", ",", "we", "suggest", "that", "this", "regulatory", "switch", "contributes", "to", "controlling", "entry", "into", "the", "cell", "cycle", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
18502
[ "Transient", "stimulation", "of", "quiescent", "B", "lymphocytes", "with", "either", "a", "cocktail", "of", "anti-CD40", ",", "anti-IgM", ",", "and", "IL4", ",", "or", "EBV", "results", "in", "the", "rapid", "expression", "of", "the", "same", "four", "genes", ",", "suggesting", "that", ",", "after", "infection", ",", "EBV", "exploits", "the", "normal", "program", "of", "B-lymphocyte", "cell", "cycle", "activation", "." ]
[ 0, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0 ]
18503
[ "Expression", "of", "the", "chemokine", "receptor", "BLR2/EBI1", "is", "specifically", "transactivated", "by", "Epstein-Barr", "virus", "nuclear", "antigen", "2", "." ]
[ 0, 0, 0, 9, 10, 9, 0, 0, 0, 0, 9, 10, 10, 10, 10, 0 ]
18504
[ "In", "our", "attempt", "to", "identify", "chemokine", "receptors", "that", "are", "related", "to", "Burkitt", "'s", "lymphoma", "receptor", "1", "(", "BLR1", ")", "and", "are", "expressed", "in", "activated", "lymphocytes", "we", "used", "RT-PCR", "resulting", "in", "the", "isolation", "of", "a", "cDNA", "encoding", "a", "seven", "transmembrane", "receptor", "termed", "BLR2", "." ]
[ 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 9, 10, 10, 10, 10, 0, 9, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0 ]
18505
[ "The", "protein", "shows", "significant", "sequence", "similarities", "to", "the", "family", "of", "G-protein", "coupled", "chemokine", "receptors", "and", "turned", "out", "to", "be", "identical", "to", "the", "recently", "described", "receptor", "EBI1", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]
18506
[ "Northern", "blot", "analysis", "revealed", "that", "BLR2", "mRNA", "could", "be", "highly", "stimulated", "in", "mitogen-", "and", "anti-CD3-treated", "peripheral", "blood", "lymphocytes", "." ]
[ 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 6, 0 ]
18507
[ "BLR2-specific", "mRNA", "could", "be", "detected", "in", "all", "Epstein-Barr", "virus", "positive", "B", "cell", "lines", "." ]
[ 3, 4, 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 6, 0 ]
18508
[ "We", "show", "that", "transcription", "of", "the", "BLR2", "gene", "could", "be", "specifically", "induced", "in", "Epstein-Barr", "virus", "negative", "BL", "41", "cells", "via", "estrogen-mediated", "activation", "of", "Epstein-Barr", "virus", "nuclear", "antigen", "2", ",", "a", "key", "regulator", "of", "viral", "and", "cellular", "genes", "in", "immortalized", "B", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 6, 0, 0, 0, 0, 9, 10, 10, 10, 10, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 5, 6, 6, 0 ]
18509
[ "Our", "data", "suggest", "an", "involvement", "of", "BLR2", "in", "the", "regulation", "of", "migration", "in", "activated", "lymphocytes", "and", "in", "viral", "pathogenesis", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0 ]
18510
[ "A", "central", "role", "for", "a", "single", "c-Myb", "binding", "site", "in", "a", "thymic", "locus", "control", "region", "." ]
[ 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 1, 2, 2, 2, 0 ]
18511
[ "Locus", "control", "regions", "(", "LCRs", ")", "are", "powerful", "assemblies", "of", "cis", "elements", "that", "organize", "the", "actions", "of", "cell-type-specific", "trans-acting", "factors", "." ]
[ 1, 2, 2, 0, 1, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 9, 10, 10, 0 ]
18512
[ "A", "2.3-kb", "LCR", "in", "the", "human", "adenosine", "deaminase", "(", "ADA", ")", "gene", "first", "intron", ",", "which", "controls", "expression", "in", "thymocytes", ",", "is", "composed", "of", "a", "200-bp", "enhancer", "domain", "and", "extended", "flanking", "sequences", "that", "facilitate", "activation", "from", "within", "chromatin", "." ]
[ 0, 9, 10, 0, 0, 1, 2, 2, 2, 2, 2, 2, 2, 2, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0 ]
18513
[ "Prior", "analyses", "have", "demonstrated", "that", "the", "enhancer", "contains", "a", "28-bp", "core", "region", "and", "local", "adjacent", "augmentative", "cis", "elements", "." ]
[ 0, 0, 0, 0, 0, 0, 1, 0, 0, 1, 2, 2, 0, 0, 0, 0, 1, 2, 0 ]
18514
[ "We", "now", "show", "that", "the", "core", "contains", "a", "single", "critical", "c-Myb", "binding", "site", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0 ]
18515
[ "In", "both", "transiently", "cotransfected", "human", "cells", "and", "stable", "chromatin-integrated", "yeast", "cells", ",", "c-Myb", "strongly", "transactivated", "reporter", "constructs", "that", "contained", "polymerized", "core", "sequences", "." ]
[ 0, 0, 5, 6, 6, 6, 0, 0, 5, 6, 6, 0, 9, 0, 1, 2, 2, 0, 0, 1, 2, 2, 0 ]
18516
[ "c-Myb", "protein", "was", "strongly", "evident", "in", "T", "lymphoblasts", "in", "which", "the", "enhancer", "was", "active", "and", "was", "localized", "within", "discrete", "nuclear", "structures", "." ]
[ 9, 10, 0, 0, 0, 0, 7, 8, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
18517
[ "Fetal", "murine", "thymus", "exhibited", "a", "striking", "concordance", "of", "endogenous", "c-myb", "expression", "with", "that", "of", "mouse", "ADA", "and", "human", "ADA", "LCR", "-directed", "transgene", "expression", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 1, 2, 0, 1, 2, 2, 0, 0, 0, 0 ]
18518
[ "Point", "mutation", "of", "the", "c-Myb", "site", "within", "the", "intact", "2.3-kb", "LCR", "severely", "attenuated", "enhancer", "activity", "in", "transfections", "and", "LCR", "activity", "in", "transgenic", "thymocytes", "." ]
[ 0, 0, 0, 0, 1, 2, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 5, 6, 0 ]
18519
[ "Within", "the", "context", "of", "a", "complex", "enhancer", "and", "LCR", ",", "c-Myb", "can", "act", "as", "an", "organizer", "of", "thymocyte-specific", "gene", "expression", "via", "a", "single", "binding", "site", "." ]
[ 0, 0, 0, 0, 0, 1, 2, 0, 1, 0, 9, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0 ]
18520
[ "A", "regulatory", "element", "in", "the", "human", "interleukin", "2", "gene", "promoter", "is", "a", "binding", "site", "for", "the", "zinc", "finger", "proteins", "Sp1", "and", "EGR-1", "." ]
[ 0, 1, 2, 0, 0, 1, 2, 2, 2, 2, 0, 0, 1, 2, 0, 0, 9, 10, 10, 9, 0, 9, 0 ]
18521
[ "Activation", "of", "the", "interleukin", "2", "(", "IL-2", ")", "gene", "after", "antigen", "recognition", "is", "a", "critical", "event", "for", "T", "cell", "proliferation", "and", "effector", "function", "." ]
[ 0, 0, 0, 1, 2, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
18522
[ "Prior", "studies", "have", "identified", "several", "transcription", "factors", "that", "contribute", "to", "the", "activity", "of", "the", "IL-2", "promoter", "in", "stimulated", "T", "lymphocytes", "." ]
[ 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 7, 8, 8, 0 ]
18523
[ "Here", "we", "describe", "a", "novel", "regulatory", "element", "within", "the", "IL-2", "promoter", "located", "immediately", "upstream", "of", "the", "nuclear", "factor", "of", "activated", "T", "cell", "(", "NFAT", ")", "domain", "." ]
[ 0, 0, 0, 0, 0, 1, 2, 0, 0, 1, 2, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 2, 2, 2, 2, 0 ]
18524
[ "This", "region", "(", "termed", "the", "zinc", "finger", "protein", "binding", "region", "(", "ZIP", ")", ")", "serves", "as", "binding", "site", "for", "two", "differently", "regulated", "zinc", "finger", "proteins", ":", "the", "constitutively", "expressed", "transcription", "factor", "Sp1", "and", "the", "inducible", "early", "growth", "response", "protein", "EGR-1", "." ]
[ 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 9, 10, 10, 10, 9, 0, 0, 9, 10, 10, 10, 10, 9, 0 ]
18525
[ "In", "unstimulated", "cells", "which", "do", "not", "secrete", "IL-2", ",", "only", "Sp1", "binds", "to", "this", "region", ",", "while", "in", "stimulated", "IL-2", "secreting", "cells", "the", "inducible", "EGR-1", "protein", "recognizes", "this", "element", "." ]
[ 0, 7, 8, 0, 0, 0, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 0, 9, 10, 10, 0, 0, 0, 0 ]
18526
[ "In", "Jurkat", "T", "cells", ",", "the", "ZIP", "site", "serves", "as", "an", "activator", "for", "IL-2", "gene", "expression", ",", "and", "a", "combination", "of", "ZIP", "and", "NFAT", "binding", "sites", "is", "required", "for", "maximal", "IL-2", "promoter", "activity", "." ]
[ 0, 5, 6, 6, 0, 0, 1, 2, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 1, 0, 1, 2, 2, 0, 0, 0, 0, 1, 2, 0, 0 ]
18527
[ "These", "results", "suggest", "a", "critical", "role", "of", "the", "ZIP", "site", "for", "IL-2", "promoter", "activity", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 1, 2, 0, 0 ]
18528
[ "Activation", "of", "the", "HIV-1", "enhancer", "by", "the", "LEF-1", "HMG", "protein", "on", "nucleosome-assembled", "DNA", "in", "vitro", "." ]
[ 0, 0, 0, 1, 2, 0, 0, 9, 10, 10, 0, 1, 2, 0, 0, 0 ]
18529
[ "Lymphoid", "enhancer-binding", "factor", "1", "(", "LEF-1", ")", "is", "a", "regulatory", "high", "mobility", "group", "(", "HMG", ")", "protein", "that", "activates", "the", "T", "cell", "receptor", "alpha", "(", "TCR", "alpha", ")", "enhancer", "in", "a", "context-restricted", "manner", "in", "T", "cells", "." ]
[ 9, 10, 10, 10, 0, 9, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 1, 2, 2, 2, 2, 2, 2, 2, 2, 0, 0, 0, 0, 0, 7, 8, 0 ]
18530
[ "In", "this", "paper", "we", "demonstrate", "that", "the", "distal", "region", "of", "the", "human", "immunodeficiency", "virus-1", "(", "HIV-1", ")", "enhancer", ",", "which", "contains", "DNA-binding", "sites", "for", "LEF-1", "and", "Ets-1", ",", "also", "provides", "a", "functional", "context", "for", "activation", "by", "LEF-1", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 2, 0, 0, 0, 1, 2, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
18531
[ "First", ",", "we", "show", "that", "mutations", "in", "the", "LEF-1-binding", "site", "inhibit", "the", "activity", "of", "multimerized", "copies", "of", "the", "HIV-1", "enhancer", "in", "Jurkat", "T", "cells", ",", "and", "that", "LEF-1/GAL4", "can", "activate", "a", "GAL4-substituted", "HIV-1", "enhancer", "80-", "to", "100-fold", "in", "vivo", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 1, 2, 0, 0, 1, 2, 0, 5, 6, 6, 0, 0, 0, 9, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0 ]
18532
[ "Second", ",", "recombinant", "LEF-1", "is", "shown", "to", "activate", "HIV-1", "transcription", "on", "chromatin-assembled", "DNA", "in", "vitro", "." ]
[ 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0 ]
18533
[ "By", "using", "a", "nucleosome", "-assembly", "system", "derived", "from", "Drosophila", "embryos", ",", "we", "find", "that", "the", "packaging", "of", "DNA", "into", "chromatin", "in", "vitro", "strongly", "represses", "HIV-1", "transcription", "and", "that", "repression", "can", "be", "counteracted", "efficiently", "by", "preincubation", "of", "the", "DNA", "with", "LEF-1", "(", "or", "LEF-1", "and", "Ets-1", ")", "supplemented", "with", "fractions", "containing", "the", "promoter-binding", "protein", ",", "Sp1", "." ]
[ 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0 ]
18534
[ "Addition", "of", "TFE-3", ",", "which", "binds", "to", "an", "E-box", "motif", "upstream", "of", "the", "LEF-1", "and", "Ets-1", "sites", ",", "further", "augments", "transcription", "in", "this", "system", "." ]
[ 0, 0, 9, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0 ]
18535
[ "Individually", "or", "collectively", ",", "none", "of", "the", "three", "enhancer-binding", "proteins", "(", "LEF-1", ",", "Ets-1", ",", "and", "TFE-3", ")", "could", "activate", "transcription", "in", "the", "absence", "of", "Sp1", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
18536
[ "A", "truncation", "mutant", "of", "LEF-1", "(", "HMG-88", ")", ",", "which", "contains", "the", "HMG", "box", "but", "lacks", "the", "trans-activation", "domain", ",", "did", "not", "activate", "transcription", "from", "nucleosomal", "DNA", ",", "indicating", "that", "bending", "of", "DNA", "by", "the", "HMG", "domain", "is", "not", "sufficient", "to", "activate", "transcription", "in", "vitro", "." ]
[ 0, 9, 10, 0, 9, 0, 9, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
18537
[ "We", "conclude", "that", "transcription", "activation", "by", "LEF-1", "in", "vitro", "is", "a", "chromatin", "-dependent", "process", "that", "requires", "a", "functional", "trans-activation", "domain", "in", "addition", "to", "the", "HMG", "domain", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 9, 10, 0 ]
18538
[ "HIV-1", "envelope", "glycoproteins", "induce", "activation", "of", "activated", "protein-1", "in", "CD4+", "T", "cells", "[", "published", "erratum", "appears", "in", "J", "Biol", "Chem", "1995", "Dec", "1", ";", "270", "(", "48", ")", ":", "29038", "]" ]
[ 9, 10, 10, 0, 0, 0, 0, 9, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
18539
[ "Activation", "of", "CD4", "positive", "T", "cells", "is", "a", "primary", "requirement", "for", "human", "immunodeficiency", "virus", "(", "HIV", ")", "entry", ",", "efficient", "HIV", "replication", ",", "and", "progression", "to", "AIDS", ",", "Utilizing", "CD4", "positive", "T", "cell", "lines", "and", "purified", "T", "cells", "from", "normal", "individuals", ",", "we", "have", "demonstrated", "that", "native", "envelope", "glycoproteins", "of", "HIV", ",", "gp", "160", ",", "can", "induce", "activation", "of", "transcription", "factor", ",", "activated", "protein-1", "(", "AP-1", ")", "." ]
[ 0, 0, 7, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 0, 9, 0, 0 ]
18540
[ "The", "stimulatory", "effects", "of", "gp160", "are", "mediated", "through", "the", "CD4", "molecule", ",", "since", "treatment", "of", "gp160", "with", "soluble", "CD4-IgG", "abrogates", "its", "activity", ",", "and", "CD4", "negative", "T", "cell", "lines", "fail", "to", "be", "stimulated", "with", "gp160", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 0, 0, 0, 0, 0, 9, 0 ]
18541
[ "Immunoprecipitation", "of", "the", "gp", "160", "-induced", "nuclear", "extracts", "with", "polyclonal", "antibodies", "to", "Fos", "and", "Jun", "proteins", "indicates", "that", "AP-1", "complex", "is", "comprised", "of", "members", "of", "these", "family", "of", "proteins", "." ]
[ 0, 0, 0, 9, 10, 0, 0, 0, 0, 9, 10, 0, 9, 0, 9, 10, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
18542
[ "The", "gp160-induced", "AP-1", "complex", "is", "dependent", "upon", "protein", "tyrosine", "phosphorylation", "and", "is", "protein", "synthesis-independent", "." ]
[ 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
18543
[ "This", "stimulation", "can", "also", "be", "abolished", "by", "inhibitors", "of", "protein", "kinase", "C", ",", "but", "it", "is", "unaffected", "by", "calcium", "channel", "blocker", "or", "cyclosporine", "A", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
18544
[ "This", "gp160", "treatment", "adversely", "affects", "the", "functional", "capabilities", "of", "T", "cells", ":", "pre-treatment", "of", "CD4+", "T", "cells", "with", "gp160", "for", "4", "h", "at", "37", "degrees", "C", "inhibited", "anti-CD3", "-induced", "interleukin-2", "secretion", "." ]
[ 0, 9, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 7, 8, 8, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0 ]
18545
[ "Effects", "similar", "to", "gp160", "were", "seen", "with", "anti-CD4", "mAb", "." ]
[ 0, 0, 0, 9, 0, 0, 0, 9, 10, 0 ]
18546
[ "The", "aberrant", "activation", "of", "AP-1", "by", "gp160", "in", "CD4", "positive", "T", "cells", "could", "result", "in", "up-regulation", "of", "cytokines", "containing", "AP-1", "sites", ",", "e.g", ".", "interleukin-3", "and", "granulocyte", "macrophage", "colony-stimulating", "factor", ",", "and", "concurrently", "lead", "to", "T", "cell", "unresponsiveness", "by", "inhibiting", "interleukin-2", "secretion", "." ]
[ 0, 0, 0, 0, 9, 0, 9, 0, 7, 8, 8, 8, 0, 0, 0, 0, 0, 9, 0, 1, 2, 0, 0, 0, 9, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 9, 0, 0 ]