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LLM-Enzyme-Kinetics-Golden-Benchmark

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train · 4.24k rows

ID_gold int64 1 4.37k	pubmed_id int64 1.88M 33.4M	Enzyme stringclasses 283 values	Organism stringclasses 232 values	Substrate stringlengths 1 81 ⌀	km(mM) stringlengths 1 8 ⌀	kcat(s^-1) stringlengths 1 10 ⌀	km_kcat(mM^-1s^-1) stringlengths 1 12 ⌀	Commentary[Temp] stringclasses 70 values	Commentary[pH] stringclasses 102 values	Commentary[Mutant] stringclasses 806 values	Commentary[Cosubstrate] stringclasses 200 values	Reference[Table/Text] stringclasses 4 values
249	25,406,072	AANATA	Drosophila melanogaster	3-(Trifluoromethyl)phenethylamine	0.11	71	650	22°C	8.0	WT	300 mM Tris-HCl pH 8.0, 150 μM DTNB, 500 μM acetyl-CoA	Table
250	25,406,072	AANATA	Drosophila melanogaster	5-Methoxytyrptamine	0.054	35	640	22°C	8.0	WT	300 mM Tris-HCl pH 8.0, 150 μM DTNB, 500 μM acetyl-CoA	Table
251	25,406,072	AANATA	Drosophila melanogaster	Norepinephrine	0.032	20	600	22°C	8.0	WT	300 mM Tris-HCl pH 8.0, 150 μM DTNB, 500 μM acetyl-CoA	Table
252	25,406,072	AANATA	Drosophila melanogaster	Phenethylamine	0.056	30	500	22°C	8.0	WT	300 mM Tris-HCl pH 8.0, 150 μM DTNB, 500 μM acetyl-CoA	Table
253	25,406,072	AANATA	Drosophila melanogaster	β-Methylphenethylamine	0.047	15	320	22°C	8.0	WT	300 mM Tris-HCl pH 8.0, 150 μM DTNB, 500 μM acetyl-CoA	Table
254	25,406,072	AANATA	Drosophila melanogaster	3-Methoxyphenethylamine	0.12	38	320	22°C	8.0	WT	300 mM Tris-HCl pH 8.0, 150 μM DTNB, 500 μM acetyl-CoA	Table
255	25,406,072	AANATA	Drosophila melanogaster	Serotonin	0.11	29.7	270	22°C	8.0	WT	300 mM Tris-HCl pH 8.0, 150 μM DTNB, 500 μM acetyl-CoA	Table
256	25,406,072	AANATA	Drosophila melanogaster	7-Methyltryptamine	0.13	21.2	160	22°C	8.0	WT	300 mM Tris-HCl pH 8.0, 150 μM DTNB, 500 μM acetyl-CoA	Table
257	25,406,072	AANATA	Drosophila melanogaster	3,4-Methylenedioxyphenethylamine	0.34	26	78	22°C	8.0	WT	300 mM Tris-HCl pH 8.0, 150 μM DTNB, 500 μM acetyl-CoA	Table
258	25,406,072	AANATA	Drosophila melanogaster	4-Methoxyphenethylamine	0.78	41	52	22°C	8.0	WT	300 mM Tris-HCl pH 8.0, 150 μM DTNB, 500 μM acetyl-CoA	Table
259	25,406,072	AANATA	Drosophila melanogaster	4-Phenylbutylamine	0.27	3.7	14	22°C	8.0	WT	300 mM Tris-HCl pH 8.0, 150 μM DTNB, 500 μM acetyl-CoA	Table
260	25,406,072	AANATA	Drosophila melanogaster	3,4-Dimethoxyphenethylamine	3.2	30	10	22°C	8.0	WT	300 mM Tris-HCl pH 8.0, 150 μM DTNB, 500 μM acetyl-CoA	Table
261	25,406,072	AANATA	Drosophila melanogaster	Acetyl-CoA	0.039	16	410	null	null	WT	300 mM Tris-HCl (pH 8.0), 150 μM DTNB, 1.0 mM tyramine	Table
262	25,406,072	AANATA	Drosophila melanogaster	Acetyl-CoA	0.032	1.26	39	null	null	E47A	300 mM Tris-HCl (pH 8.0), 150 μM DTNB, 1.0 mM tyramine	Table
263	25,406,072	AANATA	Drosophila melanogaster	Tyramine	0.16	1	6	null	null	E47A	300 mM Tris-HCl pH 8.0, 150 μM DTNB, 500 μM acetyl-CoA	Table
264	25,406,072	AANATA	Drosophila melanogaster	Acetyl-CoA	0.19	1.4	7.3	null	null	P48A	300 mM Tris-HCl (pH 8.0), 150 μM DTNB, 1.0 mM tyramine	Table
265	25,406,072	AANATA	Drosophila melanogaster	Tyramine	0.47	0.86	1.84	null	null	P48A	300 mM Tris-HCl pH 8.0, 150 μM DTNB, 500 μM acetyl-CoA	Table
266	25,406,072	AANATA	Drosophila melanogaster	Acetyl-CoA	0.081	8.6	110	null	null	Y64A	300 mM Tris-HCl (pH 8.0), 150 μM DTNB, 1.0 mM tyramine	Table
267	25,406,072	AANATA	Drosophila melanogaster	Tyramine	0.087	8.8	100	null	null	Y64A	300 mM Tris-HCl pH 8.0, 150 μM DTNB, 500 μM acetyl-CoA	Table
268	25,406,072	AANATA	Drosophila melanogaster	Acetyl-CoA	0.08	27.5	340	null	null	D142A	300 mM Tris-HCl (pH 8.0), 150 μM DTNB, 1.0 mM tyramine	Table
269	25,406,072	AANATA	Drosophila melanogaster	Tyramine	0.017	25	1500	null	null	D142A	300 mM Tris-HCl pH 8.0, 150 μM DTNB, 500 μM acetyl-CoA	Table
270	25,406,072	AANATA	Drosophila melanogaster	Acetyl-CoA	0.43	106	250	null	null	R153A	300 mM Tris-HCl (pH 8.0), 150 μM DTNB, 1.0 mM tyramine	Table
271	25,406,072	AANATA	Drosophila melanogaster	Tyramine	0.29	98	340	null	null	R153A	300 mM Tris-HCl pH 8.0, 150 μM DTNB, 500 μM acetyl-CoA	Table
272	25,406,072	AANATA	Drosophila melanogaster	Acetyl-CoA	0.12	17.9	150	null	null	H178A	300 mM Tris-HCl (pH 8.0), 150 μM DTNB, 1.0 mM tyramine	Table
273	25,406,072	AANATA	Drosophila melanogaster	Tyramine	0.025	14.7	590	null	null	H178A	300 mM Tris-HCl pH 8.0, 150 μM DTNB, 500 μM acetyl-CoA	Table
274	25,406,072	AANATA	Drosophila melanogaster	Acetyl-CoA	0.026	19.1	730	null	null	C181A	300 mM Tris-HCl (pH 8.0), 150 μM DTNB, 1.0 mM tyramine	Table
275	25,406,072	AANATA	Drosophila melanogaster	Tyramine	0.017	22	1300	null	null	C181A	300 mM Tris-HCl pH 8.0, 150 μM DTNB, 500 μM acetyl-CoA	Table
276	25,406,072	AANATA	Drosophila melanogaster	Acetyl-CoA	0.029	5	170	null	null	S186A	300 mM Tris-HCl (pH 8.0), 150 μM DTNB, 1.0 mM tyramine	Table
277	25,406,072	AANATA	Drosophila melanogaster	Tyramine	0.073	5	69	null	null	S186A	300 mM Tris-HCl pH 8.0, 150 μM DTNB, 500 μM acetyl-CoA	Table
278	25,406,072	AANATA	Drosophila melanogaster	Acetyl-CoA	0.043	8.9	210	null	null	S182A/S186A	300 mM Tris-HCl (pH 8.0), 150 μM DTNB, 1.0 mM tyramine	Table
279	25,406,072	AANATA	Drosophila melanogaster	Tyramine	0.19	8.3	43	null	null	S182A/S186A	300 mM Tris-HCl pH 8.0, 150 μM DTNB, 500 μM acetyl-CoA	Table
280	25,406,072	AANATA	Drosophila melanogaster	Acetyl-CoA	0.16	4.2	26	null	null	H220A	300 mM Tris-HCl (pH 8.0), 150 μM DTNB, 1.0 mM tyramine	Table
281	25,406,072	AANATA	Drosophila melanogaster	Tyramine	0.082	4.1	49	null	null	H220A	300 mM Tris-HCl pH 8.0, 150 μM DTNB, 500 μM acetyl-CoA	Table
282	26,002,966	AKR1C35	Golden hamster	S-tetralol	2.4	0.15	0.063333	25°C	7.4	WT	NADP+	Table
283	26,002,966	AKR1C35	Golden hamster	S-tetralol	0.023	0.113333	5	25°C	7.4	WT	NAD+	Table
284	26,002,966	AKR1C35	Golden hamster	S-camphorquinone	0.017	0.103333	6	25°C	7.4	WT	NADH	Table
285	26,002,966	AKR1C34	Golden hamster	S-tetralol	1.38	0.091667	0.066667	25°C	7.4	WT	NADP+	Table
286	26,002,966	AKR1C34	Golden hamster	S-tetralol	0.013	0.025	2	25°C	7.4	WT	NAD+	Table
287	26,002,966	AKR1C34	Golden hamster	S-camphorquinone	0.013	0.166667	12.666667	25°C	7.4	WT	NADH	Table
288	26,002,966	AKR1C35	Golden hamster	S-Tetralol	0.061	0.105	1.666667	25°C	7.4	WT	1.0 mM NAD+	Table
289	26,002,966	AKR1C34	Golden hamster	S-Tetralol	0.0015	0.025	16.666667	25°C	7.4	WT	1.0 mM NAD+	Table
290	26,002,966	AKR1C35	Golden hamster	Geranylgeraniol	0.0012	0.038333	33.333333	25°C	7.4	WT	1.0 mM NAD+	Table
291	26,002,966	AKR1C34	Golden hamster	Geranylgeraniol	0.001	0.007667	null	25°C	7.4	WT	1.0 mM NAD+	Table
292	26,002,966	AKR1C35	Golden hamster	β-3-Hydroxyhexobarbital	0.013	0.096667	7.5	25°C	7.4	WT	1.0 mM NAD+	Table
293	26,002,966	AKR1C34	Golden hamster	β-3-Hydroxyhexobarbital	0.04	0.025	0.633333	25°C	7.4	WT	1.0 mM NAD+	Table
294	26,002,966	AKR1C35	Golden hamster	1-Acenaphthenol	0.148	0.283333	1.833333	25°C	7.4	WT	1.0 mM NAD+	Table
295	26,002,966	AKR1C34	Golden hamster	1-Acenaphthenol	0.023	0.021667	0.95	25°C	7.4	WT	1.0 mM NAD+	Table
296	26,002,966	AKR1C35	Golden hamster	S-1-Indanol	0.181	0.1	0.55	25°C	7.4	WT	1.0 mM NAD+	Table
297	26,002,966	AKR1C34	Golden hamster	S-1-Indanol	0.0012	0.028333	23.333333	25°C	7.4	WT	1.0 mM NAD+	Table
298	26,002,966	AKR1C35	Golden hamster	R-Tetralol	0.095	0.0075	0.083333	25°C	7.4	WT	1.0 mM NAD+	Table
299	26,002,966	AKR1C34	Golden hamster	R-Tetralol	0.028	0.021667	0.783333	25°C	7.4	WT	1.0 mM NAD+	Table
300	26,002,966	AKR1C35	Golden hamster	trans-Benzene dihydrodiol	1	null	null	25°C	7.4	WT	1.0 mM NAD+	Table
301	26,002,966	AKR1C34	Golden hamster	trans-Benzene dihydrodiol	0.011	0.033333	3	25°C	7.4	WT	1.0 mM NAD+	Table
302	26,002,966	AKR1C35	Golden hamster	cis-Benzene dihydrodiol	0.63	0.031667	null	25°C	7.4	WT	1.0 mM NAD+	Table
303	26,002,966	AKR1C34	Golden hamster	cis-Benzene dihydrodiol	0.0097	0.025	2.5	25°C	7.4	WT	1.0 mM NAD+	Table
304	26,002,966	AKR1C35	Golden hamster	2-Cyclohexen-1-ol	0.569	0.028333	null	25°C	7.4	WT	1.0 mM NAD+	Table
305	26,002,966	AKR1C34	Golden hamster	2-Cyclohexen-1-ol	0.026	0.04	1.55	25°C	7.4	WT	1.0 mM NAD+	Table
306	26,002,966	AKR1C35	Golden hamster	Cyclohexanol	null	null	null	25°C	7.4	WT	1.0 mM NAD+	Table
307	26,002,966	AKR1C34	Golden hamster	Cyclohexanol	0.074	null	null	25°C	7.4	WT	1.0 mM NAD+	Table
308	26,002,966	AKR1C35	Golden hamster	β-Ionol	0.0097	0.053333	5.333333	25°C	7.4	WT	1.0 mM NAD+	Table
309	26,002,966	AKR1C34	Golden hamster	β-Ionol	0.001	0.021667	21.666667	25°C	7.4	WT	1.0 mM NAD+	Table
310	26,002,966	AKR1C35	Golden hamster	Farnesol	0.011	0.0045	0.416667	25°C	7.4	WT	1.0 mM NAD+	Table
311	26,002,966	AKR1C34	Golden hamster	Farnesol	0.0012	0.018333	14.166667	25°C	7.4	WT	1.0 mM NAD+	Table
312	26,002,966	AKR1C35	Golden hamster	Geraniol	0.076	0.015333	null	25°C	7.4	WT	1.0 mM NAD+	Table
313	26,002,966	AKR1C34	Golden hamster	Geraniol	0.0041	0.023333	5.666667	25°C	7.4	WT	1.0 mM NAD+	Table
314	26,002,966	AKR1C35	Golden hamster	a-3-Hydroxyhexobarbital	0.03	0.04	2.166667	25°C	7.4	WT	1.0 mM NAD+	Table
315	26,002,966	AKR1C34	Golden hamster	a-3-Hydroxyhexobarbital	0.014	0.018333	1.3	25°C	7.4	WT	1.0 mM NAD+	Table
316	26,002,966	AKR1C35	Golden hamster	Nerol	null	null	null	25°C	7.4	WT	1.0 mM NAD+	Table
317	26,002,966	AKR1C34	Golden hamster	Nerol	0.011	0.023333	2.166667	25°C	7.4	WT	1.0 mM NAD+	Table
318	26,002,966	AKR1C35	Golden hamster	3α-Hydroxyprogesterone	null	null	null	25°C	7.4	WT	1.0 mM NAD+	Table
319	26,002,966	AKR1C35	Golden hamster	5β-Pregnan-3α-ol-20-one	null	null	null	25°C	7.4	WT	1.0 mM NAD+	Table
320	26,002,966	AKR1C35	Golden hamster	5β-Androstan-3α-ol-17-one	null	null	null	25°C	7.4	WT	1.0 mM NAD+	Table
321	26,002,966	AKR1C34	Golden hamster	3α-Hydroxyprogesterone	0.0005	0.005833	11.666667	25°C	7.4	WT	1.0 mM NAD+	Table
322	26,002,966	AKR1C34	Golden hamster	5β-Pregnan-3α-ol-20-one	0.001	0.002	2	25°C	7.4	WT	1.0 mM NAD+	Table
323	26,002,966	AKR1C34	Golden hamster	5β-Androstan-3α-ol-17-one	0.0005	null	null	25°C	7.4	WT	1.0 mM NAD+	Table
324	26,002,966	AKR1C35	Golden hamster	3β-Hydroxyprogesterone	0.0009	null	null	25°C	7.4	WT	1.0 mM NAD+	Table
325	26,002,966	AKR1C35	Golden hamster	5α-Androstan-3β-ol-17-one	0.0025	0.026667	10.666667	25°C	7.4	WT	1.0 mM NAD+	Table
326	26,002,966	AKR1C35	Golden hamster	5α-Pregnan-3β-ol-20-one	0.0039	0.013	3.333333	25°C	7.4	WT	1.0 mM NAD+	Table
327	26,002,966	AKR1C35	Golden hamster	Dehydroepiandrosterone	0.0043	0.01	2.333333	25°C	7.4	WT	1.0 mM NAD+	Table
328	26,002,966	AKR1C35	Golden hamster	5β-Androstan-3β-ol-17-one	0.046	null	null	25°C	7.4	WT	1.0 mM NAD+	Table
329	26,002,966	AKR1C35	Golden hamster	5β-Pregnan-3β-ol-20-one	0.0068	null	null	25°C	7.4	WT	1.0 mM NAD+	Table
330	26,002,966	AKR1C35	Golden hamster	5β-Pregnane-3β,21-diol-20-one	0.015	0.004333	null	25°C	7.4	WT	1.0 mM NAD+	Table
331	26,002,966	AKR1C34	Golden hamster	3β-Hydroxyprogesterone	null	null	null	25°C	7.4	WT	1.0 mM NAD+	Table
332	26,002,966	AKR1C34	Golden hamster	5α-Androstan-3β-ol-17-one	null	null	null	25°C	7.4	WT	1.0 mM NAD+	Table
333	26,002,966	AKR1C34	Golden hamster	5α-Pregnan-3β-ol-20-one	null	null	null	25°C	7.4	WT	1.0 mM NAD+	Table
334	26,002,966	AKR1C34	Golden hamster	Dehydroepiandrosterone	null	null	null	25°C	7.4	WT	1.0 mM NAD+	Table
335	26,002,966	AKR1C34	Golden hamster	5β-Androstan-3β-ol-17-one	null	null	null	25°C	7.4	WT	1.0 mM NAD+	Table
336	26,002,966	AKR1C34	Golden hamster	5β-Pregnan-3β-ol-20-one	null	null	null	25°C	7.4	WT	1.0 mM NAD+	Table
337	26,002,966	AKR1C34	Golden hamster	5β-Pregnane-3β,21-diol-20-one	null	null	null	25°C	7.4	WT	1.0 mM NAD+	Table
338	26,002,966	AKR1C35	Golden hamster	17β-Estradiol	0.0004	0.046667	116.666667	25°C	7.4	WT	1.0 mM NAD+	Table
339	26,002,966	AKR1C35	Golden hamster	Testosterone	0.0081	0.028333	3.5	25°C	7.4	WT	1.0 mM NAD+	Table
340	26,002,966	AKR1C35	Golden hamster	5α-DHT	0.0076	0.021667	2.833333	25°C	7.4	WT	1.0 mM NAD+	Table
341	26,002,966	AKR1C35	Golden hamster	5β-DHT	0.013	0.007833	null	25°C	7.4	WT	1.0 mM NAD+	Table
342	26,002,966	AKR1C34	Golden hamster	17β-Estradiol	null	null	null	25°C	7.4	WT	1.0 mM NAD+	Table
343	26,002,966	AKR1C34	Golden hamster	Testosterone	0.0034	0.008833	2.666667	25°C	7.4	WT	1.0 mM NAD+	Table
344	26,002,966	AKR1C34	Golden hamster	5α-DHT	0.0006	0.010167	16.666667	25°C	7.4	WT	1.0 mM NAD+	Table
345	26,002,966	AKR1C34	Golden hamster	5β-DHT	0.0012	0.006167	5.166667	25°C	7.4	WT	1.0 mM NAD+	Table
346	26,002,966	AKR1C35	Golden hamster	20α-Hydroxyprogesterone	null	null	null	25°C	7.4	WT	1.0 mM NAD+	Table
347	26,002,966	AKR1C35	Golden hamster	5α-Pregnan-20α-ol-3-one	null	null	null	25°C	7.4	WT	1.0 mM NAD+	Table
348	26,002,966	AKR1C34	Golden hamster	20α-Hydroxyprogesterone	0.0005	0.006167	12.333333	25°C	7.4	WT	1.0 mM NAD+	Table