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[ "A weekend visit to the Distillery District's wildly popular Toronto Christmas Market this holiday season will cost you an extra loonie.", "\n\nThe market introduced $5 admission on weekends in 2015 in an effort to control crowds. ", "This year, organizers have increased the fee to $6 with net proceeds going to charities including the Daily Bread Food Bank.", "\n\nWhile organizers did not charge admission on Friday nights last year, this year you will have to pay up starting at 5 p.m. Fridays. ", "The market remains free Tuesday-Friday before 5 p.m.\n\nNew in 2016 you can pay $20 and bypass any wait to get into the market. ", "Organizers suggest buying tickets online.", "\n\nYou can visit the Christmas Market for free on its opening day November 18. ", "The market runs until December 22." ]

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[ "Jupiter: Cosmic Jekyll and Hyde.", "\nIt has been widely reported that Jupiter has a profound role in shielding the terrestrial planets from comet impacts in the Solar System, and that a jovian planet is a requirement for the evolution of life on Earth. ", "To evaluate whether jovians, in fact, shield habitable planets from impacts (a phenomenon often referred to as the \"Jupiter as shield\" concept), this study simulated the evolution of 10,000 particles in each of the jovian inter-planet gaps for the cases of full-mass and embryo planets for up to 100 My. ", "The results of these simulations predict a number of phenomena that not only discount the \"Jupiter as shield\" concept, they also predict that in a Solar System like ours, large gas giants like Saturn and Jupiter had a different, and potentially even more important, role in the evolution of life on our planet by delivering the volatile-laden material required for the formation of life. ", "The simulations illustrate that, although all particles occupied \"non-life threatening\" orbits at their onset of the simulations, a significant fraction of the 30,000 particles evolved into Earth-crossing orbits. ", "A comparison of multiple runs with different planetary configurations revealed that Jupiter was responsible for the vast majority of the encounters that \"kicked\" outer planet material into the terrestrial planet region, and that Saturn assisted in the process far more than has previously been acknowledged. ", "Jupiter also tends to \"fix\" the aphelion of planetesimals at its orbit irrespective of their initial starting zones, which has the effect of slowing their passages through the inner Solar System, and thus potentially improving the odds of accretion of cometary material by terrestrial planets. ", "As expected, the simulations indicate that the full-mass planets perturb many objects into the deep outer Solar System, or eject them entirely; however, planetary embryos also did this with surprising efficiency. ", "Finally, the simulations predict that Jupiter's capacity to shield or intercept Earth-bound comets originating in the outer Solar System is poor, and that the importance of jovian planets on the formation of life is not that they act as shields, but rather that they deliver life-enabling volatiles to the terrestrial planets." ]

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[ "Q:\n\nport windows 8 apps store library\n\nis there a way to port a library developed for windows 8 app store(for c# and Xaml) so that it can be used in windows 8 apps store developed in HTML5/Javascript\n\nA:\n\nHave you tried just adding it as a reference? ", "Do you get errors if you do?", "\nI see others have done this:\nhttp://social.msdn.microsoft.com/Forums/en-US/winappswithhtml5/thread/e890e461-a6fc-4396-8a27-57ed090998a5/ \"You need to set the Output Type to WinMD in the properties.\"", "\n\n" ]

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[ "The Washington Nationals won their eighth road postseason game in a row, beating the Houston Astros, 6-2, in Game 7 of the World Series to take home the team's first ever title. ", "The Nationals and their fans celebrated like crazy, while the Astros fans flooded Minute Maid Park's exits shortly after the final out.", "\n\nOne Astros fan is particularly upset by the team's loss. ", "He had the confidence many others had heading into the series with the Astros heavily favored, but his team ended up losing, and so did his wallet.", "\n\nHouston-based mattress store owner Jim \"Mattress Mack\" McIngvale would have taken home at least $19 million dollars if the Astros kept their six inning shutout and were the ones holding the trophy at the end.", "\n\nInstead, according to Darren Rovell, McIngvale lost more than $13 million. ", "Rovell reported that McIngvale said an Astros win would have put an extra $25 million in his pocket.", "\n\nHe spoke on his betting adventure and said he would do this again without question. (", "Via The Action Network)\n\n\"I feel like I hedged perfectly. ...", "I would have loved for the Astros fans to win, but we had two bad games. ", "My mattresses obviously had profit baked into them. ", "I would do this again tomorrow — and I probably will. ", "It's fun to be part of the greatest story in gambling history.\"", "\n\nThe Astros did not put themselves in the world champion history books this year, but McIngvale definitely put himself in the betting history books. ", "This all started after McIngvale created a promotion at his store that would give customers a full refund on mattresses of $3,000 or more if the Astros won the World Series. ", "To offset the hit he would take if this came to fruition, he made multiple large bets on the team.", "\n\nA lot of gamblers were just like \"Mattress Mack\" (though with less money) and predicted this thing would be over in six games, with the Astros as the last team standing. ", "Houston was the largest favorite (-235) entering a World Series since the Boston Red Sox were -240 favorites to beat the Colorado Rockies in 2007.", "\n\nNew Jersey sportsbooks came out on top here. ", "However, if the Astros won they would have lost almost $6 million to \"Mattress Mack\" alone." ]

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[ "\"Morning, Randy.\" \"", "Hi.\" \" ", "Morning.\" \"", "Morning.\" \" ", "Good morning.\" \"", "Shelby.\" \"", "Caramel mocha.\" \"", "Judd.\" \"", "You rock.\" \"", "Thank you.\" \"", "I do rock, don't I?\" \" ", "Judd.\" \" ", "Wade.\" \"", "Aw.\" \"", "Hydration.\" \"", "It's gonna get me through.\" \" ", "You ready?\" \" ", "Let's do it.\" \"", "Now, I understand you're telling me that you think it's gay to groom your privates.\" \"", "Now, are you having one of your buddies help you run the razor?\" \" ", "Is that what's making it gay?\" \"", "Ha-ha-ha.\" \"", "Man Up.\" \"", "What do you got?\" \"", "Now we got an NBA wife that's gonna be suing her power-forward husband for half of everything because he cheated on her.\" \"", "Now, here's the story, toots.\" \"", "Hold and turn down your radio, please.\" \"...", "Destroying dudes in the paint.\" \"", "Foot and a half of rope in his pants.\" \"", "I am sending it in to him. ", "if he likes it, he'll pick up the phone.\" \"", "You don't get to be shocked when he gets road tail in Cleveland at an away game.\" \"", "Stop chasing 10s.\" \"", "Bang a 4, bang a 5.\" \"", "Look at the gratitude on their face.\" \"", "You be the best part of their year.\" \"", "Order like a man.\" \"", "Can you do us all that favor?\" \"", "Get yourself a bourbon or a whiskey neat.\" \"", "Then why did you vote for him?\" \"!\" \"", "Why did you vote for him?\" \"!\" \"", "No one made you!\" \"", "Did you get paid?\" \"!\" \" ", "Did someone give you $500?\" \"!\" \" ", "Ha-ha-ha.\" \"", "Wade, great show.\" \"", "Can we go over some syndication numbers, pal?\" \"", "Can we not do that now?\" \"", "I'm wiped, man.\" \"", "Gotta get home and take a nap.\" \"", "I'll call you.\" \"", "Okay?\" \"", "Yeah, great.\" \"", "You go home.\" \"", "Get some rest.\" \"", "I'll consolidate these for you.\" \"", "How'd it turn out?\" \" ", "She's gonna love it.\" \" ", "Nice.\" \"", "Thank you for that.\" \"", "How soon can you get me out of here?\" \"", "Financials at 1.\" \"", "I can have you home early by 3.\" \" ", "Promise?\" \" ", "Promise.\" \"", "Quinn?\" \"", "Quinn.\" \"", "Approachin' hoochies with a passion\" \" Come on, baby, come on.\" \"", "Fuck!\" \"", "Quinn!\" \" ", "Aah!\" \" ", "Oh, yeah, yeah!\" \" ", "Oh!\" \" ", "Oh, shit!\" \" ", "Harder!\" \"", "Yeah!\" \"", "Wade!\" \"", "Wade!\" \"", "Yeah!\" \"", "Unh!\" \"", "Would now be a great time to go over those numbers?\" \"", "Oh, my God!\" \" ", "How long?\" \" ", "Judd.\" \" ", "How long?\" \"!\" \" ", "A year.\" \"", "This is the first time.\" \"", "On our sides.\" \"", "How long?\" \"", "A year, Judd.\" \"", "It's not a good time, Wendy.\" \"", "Dad's dead.\" \"", "What?\" \"", "He died about an hour ago.\" \"", "No, no, no.\" \"", "Hang on.\" \"", "They said that he had more time.\" \"", "Yeah, well, apparently he didn't.\" \"", "Shit.\" \"", "How's Mom?\" \"", "She's Mom.\" \"", "You know.\" \"", "She asked me how much to tip the nurses.\" \"", "Listen, there's something else:\" \"Dad wants us to sit shiva.\" \"", "Dad's dead.\" \"", "Yeah.\" \"", "Apparently that's the optimal time to do it.\" \"", "I asked them three times to remove this awful tube.\" \"", "I mean, give the man his dignity.\" \"", "I don't understand the shiva.\" \"", "Mom's not even Jewish, and Dad was an atheist.\" \"", "A Jewish atheist.\" \"", "And this is what he wanted.\" \"", "I'm just gonna do it myself.\" \"", "No.\" \"", "It's okay, Mom.\" \"", "Let the nurses do it.\" \"", "What am I gonna do?\" \"", "Kill him?\" \"", "Mommy, leave it!\" \"", "I don't know, Judd.\" \"", "This is what he told Mom he wanted.\" \"", "And Paul is on board with it.\" \"", "And I haven't managed to track down Phillip yet.\" \"", "Hopefully, he'll check his texts.\" \"", "Okay.\" \"", "Jesus, fuck, Mom!\" \"", "It's better, don't you think?\" \"", "Mommy, put him down.\" \"", "Stop touching him.\" \" ", "Judd.\" \" ", "Hi, Mom.\" \"", "Where's Quinn, honey?\" \"", "She's got a bulging disk because of a gym accident.\" \" ", "My God.\" \"", "Is she all right?\" \" ", "She's fine.\" \"", "The doctors have her on pain medication.\" \"", "She was devastated she couldn't be here.\" \" ", "No, of course.\" \" ", "There he is, huh?\" \" ", "Mm.\" \" ", "It's okay to cry, honey.\" \" ", "Thank you.\" \" ", "Or laugh.\" \" ", "There's no correct response.\" \" ", "Okay.\" \"", "I thought maybe I would just stand here quietly in sad reflection.\" \"", "You know?\" \" ", "Linda.\" \" ", "Hi, sweetie.\" \" ", "Hi.\" \" ", "Hi.\" \" ", "Hey, Paul.\" \" ", "Judd.\" \"", "How are you?\" \" ", "Hi, sweetheart.\" \" ", "Hey, Judd.\" \"", "Hi.\" \"", "Hello.\" \"", "Look at this.\" \"", "Hi, sis.\" \"", "Got your hands full, huh?\" \" ", "A bulging disk?\" \"", "Seriously?\" \" ", "Yep.\" \"", "You have to tell Mom about Quinn.\" \"", "I'm not ready yet.\" \"", "What's different about her?\" \"", "It's the boobs.\" \"", "She had a little touch-up.\" \"", "She's going on another book tour.\" \"", "Twenty-fifth anniversary of Cradle and All.\" \" ", "God help us.\" \"", "Hey, Barry.\" \"", "Hey, pal.\" \" ", "Just send the last iteration.\" \" ", "Seriously?\" \"", "Pay attention.\" \" ", "Whoa.\" \"", "What, are you kidding me?\" \"", "Say hello to your brother-in-law.\" \"", "He's bereaved.\" \" ", "Sorry, I didn't see you.\" \" ", "Good to see you.\" \" ", "What's up, little man?\" \" ", "Mommy said \"shit\" in the car.\" \" \"", "Shit\"?\" \" ", "Yeah.\" \" ", "Oh.\" \"", "Have you been drinking all day?\" \" ", "Yeah.\" \"", "So we started out with a little booze and profanity, Mom?\" \"", "Good morning, everybody.\" \"", "Mort Altman was not a fan of ritual.\" \"", "So, in deference to him, I'm gonna limit myself to a single psalm.\" \"", "Okay?\" \"", "The Lord is my shepherd.\" \"", "I shall not want.\" \"", "He maketh me to lie down...\" \"Shut 'em down, open up shop\" \"He maketh me to lie down in green pastures.\" \"", "Shit!\" \"", "Shit, shit, shit.\" \"", "Shit, shit, shit.\" \"", "Shit.\" \"", "Shit.\" \"", "Excuse me.\" \"", "Excuse me.\" \"", "Hey, Mr. Parker.\" \" ", "Mommy.\" \" ", "Phillip.\" \"", "You came.\" \"", "Of course I came.\" \"", "Hey, hey.\" \"", "Low five, low five, low five.\" \"", "Koala Bear.\" \"", "Hey.\" \" ", "Hey, man.\" \" ", "How you doing?\" \" ", "Nice ride.\" \" ", "Yeah.\" \"", "Where's Quinn?\" \" ", "Are we all set?\" \"", "Do you mind if I keep going?\" \" ", "Holy shit.\" \"", "Sorry, Boner.\" \" ", "No, Charlie.\" \"", "Rabbi Grodner.\" \" ", "Shh.\" \"", "Nobody calls me \"Boner\" anymore.\" \"", "That was a childhood nickname.\" \"", "So now we know that.\" \"", "Um...\" \"Apologies.\" \"", "Paul, Mort's eldest son, will now say a few words.\" \"", "Boner is a man of God now?\" \" ", "That'll never stop being weird.\" \" ", "Shh.\" \"", "Come on.\" \"", "I see Mom's new tits are present and accounted for.\" \" ", "How about those?\" \" ", "Hey.\" \"", "Sorry.\" \"", "Dad would've hated this funeral.\" \"", "That's just one of the things I loved about him.\" \"", "He would've been counting the minutes till he could go down the hill turn on the game, heh and then he just would've talked about how full of shit everybody was, heh.\" \"", "They didn't really miss him.\" \"", "And he would've been wrong.\" \"", "We do miss him.\" \"", "Hey, man.\" \" ", "Hi, son.\" \" ", "Hey, Mom.\" \"", "Hey, Sunflower.\" \"", "Hey, Horry.\" \"", "Hey, Horry.\" \" ", "Sorry about Mort, man.\" \" ", "Yeah.\" \"", "Thanks, buddy.\" \"", "How you doing?\" \"", "Living the dream.\" \"", "Yeah.\" \"", "Good to see you.\" \"", "Oh, no.\" \"", "No, no, Mom, you gotta be kidding me.\" \" ", "It's actually more comfortable than it looks.\" \" ", "I doubt that.\" \"", "Wendy's kids are in Paul's room, so I gave your room to Paul.\" \"", "Nice.\" \"", "Annie's ovulating, and I figured they could use the privacy.\" \"", "Yeah.\" \"", "Well...\" \"Paul and Annie only live about a half hour away.\" \"", "How come they have to sleep here?\" \"", "I want all my kids under one roof again.\" \"", "Obviously, when Quinn gets here, we'll make different arrangements.\" \" ", "But this is okay, right?\" \" ", "Yeah.\" \" ", "Yeah?\" \" ", "It's good.\" \" ", "Be fine.\" \" ", "Okay.\" \" ", "Come up soon.\" \" ", "Okay.\" \"", "Visitors'll be here any minute.\" \"", "Judd, it's starting!\" \"", "You're shitting us, right?\" \"", "They're shiva chairs.\" \"", "You sit low to the ground as a sign of mourning.\" \"", "That's why they're like that.\" \" ", "Don't some people sit shiva for three days?\" \" ", "I've seen that.\" \"", "That's a thing.\" \" ", "It's not a thing.\" \" ", "Maybe that could be our thing.\" \" ", "It can't be.\" \" ", "They do it in California.\" \"", "We could pioneer that.\" \"", "We're not gonna pioneer it.\" \"", "Nobody here's gonna pioneer it.\" \"", "The word \"shiva\" is Hebrew for \"seven.\"\" \"", "Seven days, no work, no travel.\" \"", "Your ass is in those seats.\" \"", "Those are the rules.\" \"", "I'd love to find the word for \"three.\"\" \" ", "I don't think Dad...\" \" Stop it!\" \"", "This was your father's dying wish, and you're negotiating?\" \"", "He was not a perfect man or a perfect father, but he sure as hell was better than most.\" \" ", "Mom...\" \" No!\" \"", "Your father had one final request, and we are gonna honor it.\" \"", "It's gonna be hard, it's gonna be uncomfortable and we're gonna get on each other's nerves.\" \"", "But for the next seven days, you are all my children again.\" \"", "And you are all grounded.\" \"", "What are you waiting for?\" \"", "Come on.\" \"", "Yup.\" \"", "Any particular seat?\" \" ", "I'll take her.\" \" ", "No.\" \"", "No, I got her.\" \" ", "She's fine.\" \"", "She's exhausted.\" \"", "She should get a nap.\" \"", "Judd, Paul.\" \"", "Shh.\" \"", "You need to put a baby in that woman yesterday.\" \"", "I'm working on it.\" \" ", "Have you had your man parts checked yet?\" \" ", "Come on, not now, Wendy.\" \"", "Because you may have emptied them over the years.\" \"", "My room was next to yours.\" \"", "My room was next to yours.\" \"", "Well, this is great.\" \"", "I can tell it's gonna be a really good experience for all you guys.\" \"", "So I'm just gonna let you sit here for a bit.\" \" ", "Thanks.\" \" ", "Reconnect.\" \"", "You got it.\" \"", "I will be back later...\" \"Dude, don't.\" \"", "Stop it.\" \"...", "to make sure that nobody gets hurt.\" \"", "Phillip.\" \"", "Take care.\" \"", "I'll see you guys soon.\" \"", "Be good.\" \"", "What's that?\" \"", "What are you writing?\" \"", "What?\" \"", "Oh, I'm just jotting down a few thoughts.\" \" ", "Oh, God help us.\" \" ", "Relax.\" \"", "It's not about you.\" \" ", "It's always about us.\" \" ", "Tell that to my shrink.\" \" ", "Fine.\" \"", "Satisfied?\" \" ", "Great.\" \"", "Thank you.\" \"", "What happens now?\" \"", "We haven't been together for ages, so why don't you just take some time you know, to catch up?\" \"", "And bitches out there don't faze me\" \"You gonna get that?\" \"", "A ho is a ho A bitch is a bitch is a bitch, so\" \"Thanks for the music.\" \"", "Maybe you got a vibrate switch on that thing.\" \"", "Just an aside.\" \"", "Hey.\" \"", "Are phone calls allowed?\" \"", "What?\" \"", "Oh, no, no, no.\" \"", "No, we're just sitting in an awkward silence.\" \"", "She's here.\" \"", "And by \"she\" he means...?\" \"", "What's going on?\" \"", "What's happening?\" \"", "Who is that?\" \"", "Is that his lawyer?\" \"", "Is Phillip in trouble again?\" \"", "When is he not in trouble?\" \" ", "Okay, that's not his lawyer.\" \" ", "Oh.\" \"", "Why not?\" \"", "It would be so like Phillip to be doing his lawyer.\" \"", "Let's go.\" \"", "Go.\" \"", "Go.\" \" ", "He's coming.\" \" ", "Everyone.\" \" ", "This is Tracy.\" \" ", "Ha, ha.\" \" ", "Hey, Tracy.\" \" ", "Hi.\" \"", "Hi.\" \"", "Hi.\" \" ", "My fiancée.\" \" ", "What?\" \"!\" \" ", "Oh, boy.\" \" ", "Engaged to be engaged, actually.\" \"", "Oh.\" \"", "I'm so sorry to be meeting you all under such sad circumstances.\" \"", "I'm making a poopie.\" \" ", "Oh.\" \"", "I love doing that.\" \" ", "Okay.\" \"", "We are on the goal line.\" \"", "London just keeps moving the goalposts back.\" \"", "That's Barry.\" \"", "He's a bit of an ass.\" \" ", "Phillip.\" \" ", "It's okay.\" \"", "He can't hear us.\" \" ", "This is my brother Judd.\" \" ", "Hi.\" \"", "Pleasure.\" \" ", "My sister, Wendy.\" \" ", "Hi.\" \"", "Oldest brother, Paul.\" \" ", "His wife, Annie.\" \" ", "Hi!\" \"", "Tracy!\" \" ", "Welcome to the family!\" \"", "You're gorgeous!\" \" ", "Thank you.\" \"", "Get out while you still can.\" \"", "Heh-heh-heh.\" \"", "Funny story.\" \"", "Annie used to be Judd's girlfriend, back in the day.\" \"", "Phillip, that's enough.\" \"", "And this, of course, is my mother, Hilary Altman.\" \"", "Mrs. Altman.\" \"", "It is a tremendous honor to meet you.\" \"", "Your book, Cradle and All, was a really important book for me.\" \" ", "Agh.\" \"", "Heh-heh-heh.\" \"", "My children are not very proud of my life's work.\" \"", "All right.\" \"", "Not now, Mom.\" \"", "Every kid in Paul's class knew that he used to jerk off with an oven mitt.\" \" ", "That never happened.\" \" ", "It happened.\" \"", "Every guy I met expected me to put out.\" \"", "You had a very healthy sexual curiosity.\" \"", "Which you documented in detail after reading my diary.\" \" ", "Secrets are cancer to a family.\" \" ", "Oy.\" \"", "Well, Cradle and All was the inspiration for my dissertation.\" \"", "So I would like to think that your family's dysfunction helped me to get my Ph.D. Heh.\" \" ", "Tracy is also a therapist, Mom.\" \" ", "I gathered.\" \" ", "Heh.\" \" ", "She was my therapist, actually.\" \"", "Naturally, once we realized we had feelings for each other, I referred him to a colleague.\" \" ", "Naturally.\" \" ", "Look, Daddy, a T.\" \" That's great, sweetie.\" \"", "Go show Mommy.\" \" ", "Poopie!\" \" ", "Jesus Christ!\" \"", "What the hell is wrong with you?\" \" ", "Don't yell at him!\" \" ", "Well, he threw shit on me!\" \" ", "He's 3 years old, you asshole.\" \" ", "Where are the wipey things?\" \" \"", "Where are the wipey things?\"\" \"", "Coming out of my ass.\" \"", "There wasn't a lot of liquid, so the rug's gonna be fine.\" \"", "I got a conference call.\" \"", "What do you want me to do?\" \"", "I'll get the paper towels.\" \"", "I hope you're still on this call, I swear to God.\" \"", "To clarify, today does count as one of the seven, right?\" \"", "Okay.\" \"", "Hmm.\" \"", "A bulging disk.\" \"", "Pretty common, actually.\" \"", "We were married for...\" \"So, Paul, no children yet?\" \"", "No, no kids.\" \"", "We're working on it.\" \"", "Someday, maybe.\" \"", "Phillip, you're all grown up.\" \"", "What do you do now?\" \"", "Well, I run an alternative-fuel think tank in D.C.\" \"Isn't that something?\" \"", "It's a bulging disk.\" \"", "It's pretty common, actually.\" \" ", "Hmm.\" \"", "Hmm.\" \" ", "Usually in men, though, right?\" \"", "You do see it mostly in men, but she's pretty active.\" \"", "She's real active.\" \"", "Well, I'm managing a small, small, very private equity fund.\" \"", "Mostly small...\" \"Hey, Molly.\" \"", "Mostly small cap, emerging markets.\" \"", "All that good stuff.\" \" ", "Paul, you got any kids?\" \" ", "No, no kids yet.\" \"", "One day, maybe.\" \"", "We made love on our first date.\" \"", "In his car.\" \"", "Behind the Texaco station.\" \"", "Oh, shit.\" \"", "She's telling the Texaco story.\" \"", "Mort left the air conditioning on.\" \"", "By the time we were done, the battery was dead.\" \"", "We had to call my father to come and give him a jump start.\" \"", "Maybe they wanna hear about his hobbies.\" \"", "The stuff that's going on in fossil fuels is just really sexy.\" \"", "God, the passion, the creativity, the angles.\" \" ", "Jesus Christ.\" \" \"", "Angles\"?\" \" ", "Mort knew his way around a woman's body.\" \" ", "Mother.\" \" ", "And the sheer size of him.\" \"", "Circumference.\" \" ", "Mom.\" \" ", "I don't mind telling you, the man was hung.\" \" ", "That should've been the headstone.\" \"", "Clearly, she lost more than a husband.\" \"", "Hmm?\" \"", "Anybody need anything from the kitchen?\" \"", "No, it's true.\" \"", "I mean, I miss him and I miss it.\" \" ", "Hi.\" \" ", "Hi, Judd.\" \"", "I'm just trying to make some space.\" \"", "Hmm.\" \"", "Well, I'm gonna sneak out for a drive.\" \"", "I have a feeling Mom is just getting warmed up in there.\" \"", "The talking helps.\" \"", "Jerry died 20 years ago and I still find ways of randomly working him into conversations.\" \"", "Like right there, for instance.\" \"", "How come you never found anyone else?\" \"", "Boy.\" \"", "That was very rude.\" \"", "I apologize.\" \"", "It'd be a terrible mistake to go through life thinking people are the sum total of what you see.\" \"", "Linda, I'm an asshole.\" \"", "Just forgive me.\" \" ", "You get a free pass this week.\" \" ", "Thank you.\" \"", "And thank you for taking care of Mom these past few months.\" \"", "I'll bet she would've been a mess without you.\" \"", "Thank you.\" \"", "Why don't you swing by the store and pick up Horry?\" \"", "I don't like him walking home in the dark.\" \"", "He gets confused sometimes.\" \"", "Sure.\" \" ", "Side door.\" \"", "Clean getaway.\" \" ", "Mm-hm.\" \"", "Heh.\" \"", "Horry.\" \"", "You need a ride?\" \"", "Hey, Judd.\" \"", "Judd Altman.\" \" ", "Oh, my God.\" \" ", "Is that Penny?\" \"", "I'm so sorry about your dad.\" \"", "I should've come today.\" \"", "I'm sorry.\" \"", "I have a thing with funerals.\" \"", "I'm afraid I'll start laughing or bawling or say something inappropriate, so I don't go.\" \"", "Which is not a solution, but there you have it.\" \" ", "Anyway, what's it been?\" \"", "Seven, 8, 9 years?\" \" ", "Something like that.\" \"", "Horry said you came alone.\" \"", "What happened to Quinn?\" \" ", "You didn't split up, did you?\" \"", "Mm-mm.\" \" ", "Sorry.\" \"", "I don't know why I say these things.\" \" ", "Just a freak accident on an elliptical.\" \"", "Goddamn antidepressants I'm on.\" \"", "You know?\" \" ", "They just obliterate whatever filter I have.\" \" ", "Mm-hm.\" \"", "It's very embarrassing.\" \" ", "She left me.\" \" ", "I knew it!\" \"", "I fucking knew it!\" \" ", "I knew that.\" \"", "I'm sorry, but...\" \" Aah!\" \"", "She slept with my boss, so...\" \" Well, that'll do it.\" \" ", "Yes, it did.\" \" ", "Done.\" \" ", "Right.\" \"", "Gosh.\" \"", "And now your father.\" \"", "I'm sorry, Judd.\" \"", "You're having a profoundly shitty year.\" \"", "I've had better.\" \"", "Yeah, it's not...\" \"Anyway, so you live here still?\" \"", "My mom got very sick, so I came back to spend time with her and see that through.\" \"", "And then, I don't know, I just became the girl that never left.\" \"", "It's understandable.\" \"", "It's a pretty place.\" \"", "Are you still skating?\" \"", "Yeah, I'm still skating.\" \"", "I'm running the skating school over at Spencer's now, which is great.\" \" ", "It's perfect.\" \"", "I get to skate every day.\" \" ", "Good for you.\" \"", "The owner gives me run of the place, which is awesome in exchange for some small sexual favors.\" \"", "Hmm.\" \"", "Nice of him.\" \"", "And you.\" \"", "Great arrangement.\" \" ", "You used to laugh at my jokes.\" \" ", "No, I didn't.\" \" ", "Yes, you did.\" \" ", "I did.\" \"", "You used to be funnier.\" \"", "Well, I'm not a fan of small talk, so I'm gonna give you a hug.\" \" ", "Mm.\" \"", "Heh.\" \" ", "Mm.\" \"", "Yeah, what a surprise.\" \"", "Thanks, Horry.\" \"", "I'll pick them up tomorrow.\" \"", "I'll be outside when you're done.\" \" ", "Horry, you scared the crap out of me.\" \" ", "I have that effect on people.\" \" ", "My mother send you to get me?\" \" ", "Yes, but I was already headed out.\" \" ", "Come on.\" \"", "Get in the car.\" \" ", "Shit.\" \"", "I need to get my own place.\" \" ", "Heh.\" \"", "Why don't you?\" \" ", "Oh, brain injury.\" \" ", "There are things I can't do.\" \" ", "Like what?\" \"", "Like remember what the hell it is I can't do.\" \" ", "I can get my own car door, though.\" \"", "Thanks.", "Heh.\" \"", "Sorry.\" \"", "So Penny, huh?\" \"", "Yeah, I never figured she'd still be here.\" \"", "Why?\" \"", "Because she doesn't have a brain injury?\" \"", "No.\" \"", "No.\" \"", "Horry, sorry.\" \"", "I didn't mean it like that.\" \"", "It's just...\" \" Just...\" \" I'm just fucking with you.\" \"", "Heh, heh.\" \"", "Asshole.\" \"", "It's hard to see people from your past when your present is so cataclysmically screwed up, you know?\" \"", "Welcome to my world.\" \"", "Whoops!\" \"", "We've come apart there, Mom.\" \"", "Can you please close that robe?\" \"", "Cover it.\" \"", "They're just breasts, Judd.\" \"", "Same ones you suckled at.\" \"", "No, Mother.\" \"", "Those are not the same breasts you nursed us with.\" \"", "Those are different.\" \"", "You got bionic breasts now.\" \"", "Your father didn't see it that way.\" \"", "He liked to put his penis...\" \"Jesus Christ, Mother.\" \" ", "Thank you.\" \" ", "I love you, Judd.\" \" ", "But?\" \" ", "What do you mean, \"but\"?\" \"", "There's always a \"but\" when you say \"I love you.\"\" \"", "I was just gonna say, I don't know how you all got so repressed.\" \"", "Hmm.\" \"", "Go figure.\" \"", "Mm.\" \"", "Whew.\" \" ", "Mom, I got it.\" \"", "I got the rest.\" \" ", "You sure?\" \" ", "I appreciate the help.\" \" ", "Okay.\" \" ", "I'm upstairs if you need me.\" \" ", "Okay.\" \"", "Hopefully you'll be looking for another sash for that robe, huh?\" \"", "You gotta double-sash robe, Mom.\" \"", "You don't know what you're talking about.\" \" ", "He left it to all of us.\" \" ", "We are not having this conversation.\" \"", "Paul, I think this is a wonderful idea.\" \"", "This is bullshit.\" \"", "Dad always wanted his sons to work together.\" \"", "It's like Dad's legacy to us.\" \"", "You don't know what you're talking about.\" \"", "What do you mean?\" \"", "I'm part of this family.\" \" ", "Would you listen?\" \" ", "No, you listen.\" \"", "Dad always intended for the store to go to me.\" \"", "That's why he left half of it to me and the other half to the three of you.\" \"", "Now, after we settle the will, I'll buy out your shares at a fair valuation.\" \"", "I don't wanna sell you my share.\" \"", "I wanna run the store with you.\" \"", "How exactly do you think you can add to the business?\" \"", "I can help you grow it.\" \"", "New locations and expanded lines.\" \"", "What?\" \" ", "The only thing you've ever grown is weed.\" \" ", "And he was very good at it.\" \" ", "Mommy, come on!\" \" ", "I'm just saying, he's very entrepreneurial.\" \"", "Listen, Paul, you don't believe in me.\" \"", "I get that.\" \"", "I never believed in myself either, really.\" \"", "But I've changed.\" \"", "And you're the brains of the outfit.\" \"", "I know that.\" \"", "But what about marketing and advertising?\" \"", "What about networking?\" \"", "I'm the people person.\" \"", "That's who I am.\" \"", "And you are not one.\" \"", "You're a nice guy, but let's face it:\" \"You're a little scary.\" \"", "As a matter of fact, you're scaring me right now.\" \"", "Your face is red.\" \"", "Are you breathing?\" \"", "Is he breathing?\" \"", "Judd!\" \"", "Get in here and back me up!\" \"", "Yup.\" \"", "Paul, I do think we should talk about it.\" \" ", "Thank you.\" \" ", "Mind your business.\" \"", "It is his business.\" \"", "You said he owns a sixth of it.\" \"", "A third, because I'm gifting my share to Judd.\" \" ", "You're welcome.\" \" ", "Mm.\" \"", "Thank you.\" \"", "So together, Judd and I own half the business.\" \"", "That's awesome.\" \"", "This is my livelihood!\" \"", "You can't just make this decision.\" \" ", "Let's talk about this, please.\" \"", "We just did.\" \"", "You guys don't have a clue.\" \"", "He's not coming to work for me.\" \"", "Well, see, we'd be partners, actually, after I buy Judd's shares.\" \" ", "Little brother, you can't even buy a suit.\" \" ", "People can change, Paul.\" \"", "Okay.\" \"", "I get it.\" \" ", "How rich are you exactly, Tracy?\" \" ", "This has nothing to do with me.\" \"", "We all know the store is yours.\" \"", "No one's disputing that.\" \"", "You little whore.\" \" ", "Whoa.\" \" ", "What the fuck did you just call her?\" \" ", "Whoa, whoa, whoa.\" \" ", "No, no.\" \"", "Not her.\" \"", "You.\" \" ", "Ah.\" \" ", "You're a whore.\" \" ", "Why don't you come here and say that?\" \" ", "Here I come.\" \"", "No, no.\" \"", "Not in the house.\" \"", "Okay, this was great.\" \"", "You've given each other a lot to absorb.\" \"", "Let's agree to put a pin in it, shall we?\" \"", "And then you can assimilate the new information.\" \"", "Maybe reconsider your positions.\" \"", "Okay?\" \"", "Great.\" \" ", "Makes sense.\" \" ", "Great work, guys.\" \"", "Argh!\" \"", "You motherfucker.\" \" ", "Come here.\" \" ", "Get off.\" \" ", "Not in the house.\" \" ", "Come on, guys.\" \" ", "Are you all right?\" \" ", "Ugh.\" \"", "Whew.\" \" ", "Good morning.\" \" ", "Oh, my God.\" \"", "What?\" \" ", "What was that moment?\" \" ", "Could I talk about it?\" \"", "About your brother?\" \"", "So I'm 11 years old, and Mom's out somewhere and Dad was upstairs, like, fixing the rain gutters on the roof.\" \"", "And I am downstairs, babysitting Phillip, the eternal baby like always when I suddenly realize that I have gotten my period for the first time.\" \"", "Anyway, 11, right?\" \"", "So I run outside and call up to Dad but he's, like, using a power tool or something and can't hear me.\" \"", "I grab a baseball off the lawn and toss it up at him.\" \"", "I mean, I just meant to get his attention.\" \"", "But somehow, it hits him square in the back of the head.\" \" ", "He falls off the roof.\" \" ", "Oh, I remember that.\" \"", "Ha-ha-ha.\" \" ", "Okay.\" \"", "So we all get in the back seat.\" \"", "Dad drives to the hospital with a broken arm and a gash on his forehead.\" \"", "And the nurse looks at him and she's like, \"What in the world happened to you?\"\" \"", "And Dad just says, \"My daughter got her period.\"\" \"", "That is so fantastic, Wendy.\" \" ", "That's so much like your dad.\" \" ", "Oh, let me say hi.\" \" ", "It's your wife.\" \"", "Aren't you gonna take it?\" \" ", "I'll call her back.\" \"", "Why don't you tell another story about your cycle?\" \" ", "That was a real crowd pleaser.\" \" ", "Ha, ha!\" \"", "No, Wendy's gone already.\" \"", "It's your turn.\" \"", "Give us a good story about you and Dad.\" \"", "Oh.\" \"", "That's what we're doing, huh?\" \"", "I'm blanking.\" \"", "Maybe come back to me.\" \"", "What, you can't think of a single memory of your father?\" \" ", "Not right now.\" \"", "Go ahead.\" \" ", "No, I already went.\" \"", "Mine was amazing.\" \"", "I don't know what's going on with you, but I do know this:\" \"If you don't take the time to properly mourn your father here, you're gonna regret it.\" \"", "And shiva time.\" \" ", "Did you like the book?\" \" ", "Yeah.\" \"", "Okay.\" \"", "To you?\" \"", "That'd be perfect.\" \"", "Crazy, right?\" \" ", "I'm so sorry for your loss.\" \" ", "Thank you.\" \" ", "Hi, Wendy.\" \" ", "Hi.\" \" ", "Have some coffee.\" \" ", "No, thank you.\" \"", "I don't want any.\" \" ", "You want this coffee.\" \" ", "It's not even coffee.\" \" ", "What is that?\" \" ", "It's Dad's schnapps.\" \"", "I raided the bar.\" \"", "No, thank you.\" \"", "Get it out of my face.\" \"", "Are you drunk?\" \" ", "Don't judge me.\" \" ", "I'm not judging you.\" \"", "It's great.\" \"", "You don't really drink that much, right?\" \"", "Good for you.\" \" ", "Oh, my God, will you just take the call?\" \" ", "No.\" \"", "Just butt out.\" \"", "Please?\" \"", "This is crazy enough without you keeping your divorce a secret.\" \" ", "Be quiet, please.\" \"", "Mother's right next to me.\" \" ", "I am being quiet.\" \"", "That's the funny thing.\" \" ", "You just got louder.\" \"", "Mother's next to me.\" \" ", "If you can't tell your family, then who?\" \" ", "I would rather tell anyone else, actually.\" \" ", "That is rude.\" \" ", "Why don't you go upstairs and take a nap?\" \" ", "I can't do this anymore.\" \"", "Because this is already a new record for me keeping my mouth shut.\" \"", "Hey, drunk girl, why don't you shut your face?\" \"", "It is growing inside me like this fat hairy tumor.\" \"", "I need to let it out.\" \" ", "Seriously, put that down.\" \" ", "You're stressed out and grieving.\" \" ", "You're walking around like a ticking bomb.\" \" ", "Make the words stop coming out of your mouth.\" \"", "People ask me, \"What's going on with Judd?\" ", "I have to be like, \"I don't know.\" ", "But I do know.\" \" ", "I can't believe how much I hate you right now.\" \" ", "Listen, I love you.\" \" ", "You tell them, or I will tell them.\" \" ", "Get your hand off me, please.\" \"", "I will pinch you.\" \"", "I'll punch you.\" \"", "Judd, where is that beautiful wife of yours?\" \"", "She's gone.\" \"", "Quinn is gone.\" \"", "It's over.\" \"", "It's a little bit complicated.\" \"", "Or maybe it's not.\" \"", "She's been sleeping with my boss.\" \"", "I walked in on them having sex in my bed.\" \"", "So I guess it's not that complicated.\" \"", "It's simple.\" \"", "I'm divorcing her whore ass.\" \"", "How are you doing, Mrs. Applebaum?\" \" ", "Happy?\" \" ", "Yep.\" \"", "Thank you.\" \"", "You stop it.\" \"", "Stop it.\" \"", "Ha, ha.\" \"", "Oh, my God.\" \"", "You're like a magician.\" \"", "You okay, there?\" \"", "Yeah.\" \"", "I realize what this must look like to you all.\" \"", "I mean, this was supposed to be a fling, you know?\" \"", "Younger guy, get in, get out, move on.\" \" ", "Appropriate men are so boring, you know?\" \" ", "I do know.\" \"", "And disappointing.\" \"", "And Phillip was alive and in the moment and it wasn't supposed to turn into anything.\" \" ", "I mean, really, look at him.\" \"", "He's a moron.\" \" ", "Yeah.\" \"", "Of course, I'm the moron who fell in love with him, so...\" \"Don't worry about Chelsea.\" \"", "Phillip's skanky ex-girlfriends are a dime a dozen.\" \"", "Do they all have to look like Victoria's Secret models?\" \" ", "She's not that hot.\" \" ", "Oh, come on.\" \"", "I would do her.\" \"", "Yeah.\" \"", "I wouldn't say that in front of my brother.\" \"", "There you are.\" \"", "Hey.\" \"", "Want some help?\" \"", "So sorry about Quinn.\" \"", "Yeah, yeah.\" \"", "I'm sorry I didn't tell you any sooner.\" \"", "I just...\" \"It's been a very long time since we told each other things.\" \"", "I think we're both out of practice.\" \"", "I guess so.\" \"", "I got this.\" \"", "I'll do the rest.\" \"", "You go to bed.\" \" ", "I love you, son.\" \" ", "I love you.\" \"", "Hello?\" \"", "We're in Paul's car.\" \"", "Come on, we 're making a run for it.\" \"", "Jesus.\" \"", "Boy, this place has not changed at all, huh?\" \"", "Why mess with perfection?\" \" ", "Hi.\" \" ", "Hey.\" \"", "Ha, ha.\" \"", "They let you out, huh?\" \" ", "Oh, little bit more of a jailbreak, actually.\" \"", "PENNY:\" \"I bet.\" \"", "I'd invite you to come join us, but I think that that would probably be a huge mistake, so...\" \" Oh.\" \"", "Well, now I have to come.\" \" ", "You don't.\" \"", "Really.\" \"", "Penny.\" \"", "I'm warning you.\" \"", "Okay.\" \"", "Guys, you remember Penny.\" \"", "Hey, you guys, I just wanted to say I was so sorry to hear about Mort.\" \"", "Penny Moore?\" \"", "Wow.\" \" ", "You don't still live here.\" \" ", "I do.\" \" ", "You do?\" \" ", "Sometimes you're worse than Mom.\" \" ", "That was uncalled for.\" \" ", "You should listen to yourself.\" \"", "You should look at yourself.\" \"", "How about that?\" \"", "Can I get beers for everybody?\" \"", "Who wants a beer?\" \" ", "Way ahead of you.\" \" ", "Did you do this?\" \" ", "I just wanted a beer, Phillip.\" \" ", "They were all out.\" \"", "This is great.\" \"", "All of us together.\" \"", "I don't know why we don't do this more often.\" \"", "We don't like each other very much.\" \"", "I never got a chance to go out drinking with my brothers.\" \"", "And my sister.\" \"", "By the time I could drink, you guys were all gone.\" \" ", "This is a big moment for me.\" \"", "To my family.", "Cheers.\" \" ", "And to Dad.\" \" ", "To Dad.\" \" ", "To Dad.\" \" ", "To Dad.\" \" ", "Just have half of that.\" \" ", "Yeah.\" \"", "Judd, take care of Judd.\" \"", "That's awful.\" \" ", "So this thing with Quinn...?\" \" ", "Well, we're not gonna discuss that.\" \" ", "Can we?\" \" ", "No.\" \"", "We can't.\" \" ", "We discussed it with the whole neighborhood.\" \" ", "We did.\" \"", "Thanks to you.\" \"", "Appreciate it.\" \" ", "The whole neighborhood?\" \" ", "The whole neighborhood knows.\" \"", "It was ugly.\" \"", "Whatever you're imagining, multiply it.\" \" ", "Come on, you needed to let it out.\" \" ", "You needed to let it out.\" \" ", "I did need to let it out.\" \" ", "We don't have to talk about it anymore.\" \"", "I can't understand why she was fucking Wade Beaufart.\" \" ", "Me neither.\" \" ", "Walk me through that.\" \" ", "No, we're at Walker's.\" \" ", "Please, anything else you wanna discuss I'm happy to.\" \"", "We just got here like ten minutes ago.\" \"", "Look, you need to calm down.\" \"", "Calm down.\" \"", "Calm down.\" \"", "I'm coming home.\" \"", "I'm coming home.\" \" ", "I have to go have sex.\" \" ", "Oh.\" \" ", "In some cultures, people actually enjoy sex.\" \" ", "Well, not when it's on a schedule.\" \"", "Come on, Annie's hot.\" \"", "Not as hot as when she dated Judd, but...\" \" Why don't you shut the fuck up?\" \" ", "Here we go.\" \" ", "We're not doing this again.\" \" \"", "Again\"?\" \"", "Judd dated her six months.\" \"", "I've been married to her six years.\" \"", "At what point are you gonna stop being an asshole about it?\" \"", "I don't know.\" \"", "Maybe at the point when it stops bugging the shit out of you.\" \"", "It was actually more like nine months.\" \" ", "Jesus, Judd.\" \" ", "You never forget your first.\" \"", "I've had about enough of you today, Phillip.\" \"", "That's fair.\" \" ", "Okay.\" \" ", "Penny.\" \"", "Go take care of business.\" \" ", "You guys are idiots.\" \"", "Seriously.\" \"", "Off-the-charts.\" \" ", "What did I do?\" \" ", "Bye, Penny.\" \" ", "Bye.\" \" ", "Aw.\" \" ", "We'll take a cab.\" \"", "Or walk.\" \"", "Seven days, huh?\" \" ", "I don't know how we're gonna make it.\" \" ", "Ha, ha.\" \"", "I don't know.\" \"", "You have each other no matter what, and I think that's great.\" \"", "I'm an only child, so...\" \" That sounds so good.\" \" ", "Ha, ha.\" \"", "Does that not sound good?\" \"", "Yeah.\" \" ", "Oh.\" \"", "Hello.\" \" ", "Oh, God.\" \"", "I should've known you were gonna be out here.\" \"", "Come out here.\" \"", "I figured something out.\" \" ", "You're gonna like it.\" \"", "It's about you.\" \" ", "I'd better like it.\" \"", "I should just come out here and push you off the roof.\" \"", "Come here, Grandpa.\" \" ", "Used to be a lot easier.\" \" ", "Heh.\" \"", "No, thank you.\" \"", "You're done too.\" \" ", "It's gonna be Penny Moore.\" \"", "It's fantastic.\" \" ", "What are you talking about?\" \"", "The person that you sleep with before you get back together with Quinn.\" \"", "Is that what you've got figured out?\" \"", "I'm not sleeping with Penny.\" \"", "I mean, it's kind of poetic, actually, if you think about how crazy she was about you.\" \"", "She was a kid.\" \"", "It was a long time ago.\" \"", "Penny was in love with you.\" \"", "But you were in love with Annie.\" \"", "Until you met Quinn.\" \"", "Then you married Quinn, and she left you.\" \"", "And Annie married Paul.\" \"", "And that is the glory of love.\" \"", "We want the ones we can't have, and we crap all over the ones that we can.\" \"", "Rinse and repeat.\" \" ", "Well, you loved Horry.\" \" ", "And he loved me.\" \"", "So, of course, life had to take a steaming dump all over that one.\" \"", "And what makes you think that I'm gonna get back together with Quinn?\" \"", "Divorce is complicated.\" \"", "Starting over is complicated.\" \"", "And you don't do complicated, Judd.\" \"", "You never have.\" \"", "Bullshit.\" \"", "What are you talking about?\" \"", "You have had your whole life mapped out since you were 12 years old.\" \"", "With your pretty wife and your perfect apartment.\" \"", "That's just who you are, you know?\" \"", "No muss, no fuss.\" \"", "And so you're gonna sleep with Penny so you can forgive Quinn and then you'll get back on the road more traveled and pretend you never got off.\" \"", "Glad you got it all thought out.\" \"", "It's what I do.\" \"", "No, no, come on.\" \"", "Seriously?\" \"", "Hello?\" \"", "Hey.\" \"", "Sorry, I was blow-drying my hair.\" \"", "I think I blew a fuse.\" \"", "No, it's not your fault.\" \"", "My dad insisted on doing his own wiring.\" \"", "He actually would have preferred to have been electrocuted than pay a licensed professional.\" \"", "Oh, Jesus Christ!\" \" ", "Are you okay?\" \"", "Ha-ha-ha.\" \" ", "Not that one.\" \"", "How about this one?\" \"", "Ah, yes.\" \" ", "All right.\" \"", "Got it in two.\" \" ", "Runs in the family.\" \"", "Back to your day.\" \"", "Nicely done.\" \"", "So crazy we're all back in this house again, huh?\" \" ", "Wow.\" \" ", "What do you got there?\" \"", "Oh, this is, um, my...\" \" Something you wanna tell me?\" \" ", "Yes, I'm a drug addict.\" \"", "Ha, ha.\" \"", "Poor Annie.\" \"", "That's for the babies?\" \"", "It's my fertility medicine.\" \"", "So that's fun.\" \" ", "Sorry you're going through that.\" \" ", "Oh, it's awesome.\" \" ", "Mm-hm.\" \" ", "So not tense in any way for a marriage.\" \" ", "Mm.\" \"", "Good luck.\" \" ", "Yeah.\" \"", "Here's hoping.\" \"", "Boom, boom, boom.\" \"", "I cracked them up.\" \" ", "Come on.\" \" ", "Don't give me this shit.\" \"", "You were sitting there flirting with her in front of me, in front of your family.\" \"", "It's two friends having a conversation.\" \"", "So that's your correct answer?\" \"", "Well, apparently I'm an irredeemable asshole.\" \"", "Phillip, please tell me and my deaf children, how did you manage to seduce your therapist?\" \" ", "Why are you doing this, Phillip?\" \" ", "Doing what, Mommy?\" \" ", "Dating your mother.\" \" ", "Fuck off, Wendy.\" \" ", "Rude.\" \" ", "Sorry.\" \" ", "Well, I think Tracy is lovely.\" \" ", "Thank you.\" \"", "She's closer to my age than yours.\" \"", "I'm not as young as you like to think, and neither are you.\" \" ", "Hey.\" \" ", "Hey.\" \"", "There is no version of this scenario that doesn't end badly.\" \" ", "Kind of like this conversation?\" \" ", "Which ends right now.\" \" ", "Right behind you.\" \" ", "You cannot leave this house.\" \"", "We're sitting shiva.\" \"", "Mom, you're sitting in the same spot we put our Christmas tree.\" \"", "Oh, it's a fast car.\" \" ", "I know what you're thinking.\" \" ", "That we're gonna die?\" \"", "That I'm a screw-up and that Tracy's rich and that's why I'm with her.\" \"", "Shit.\" \"", "Phillip.\" \"", "Why are you with her?\" \"", "You know, because I love her.\" \"", "A better class of woman is helping me grow a little.\" \"", "You're using her for her class?\" \"", "I'm not using her any more than she's using me.\" \"", "But isn't that what love is?\" \"", "Two people who fulfill needs within each other?\" \"", "Slow down.\" \"", "Please.\" \"", "Phillip.\" \"", "Come on, man.\" \"", "Hey.\" \"", "Hey.\" \"", "Slow down.\" \"", "Way too fast.\" \"", "This is not a toy.\" \" ", "You wanna drive?\" \" ", "Yeah, I wanna drive.\" \"", "Pull over.\" \"", "Brake.\" \"", "That's sensible.\" \"", "Thank you.\" \" ", "Fucking bullshit.\" \" ", "See you in an hour.\" \"", "Hey, hey, hey!\" \" ", "Phillip!\" \" ", "Tell Penny I said hi!\" \"", "I told you\" \"That we could fly\" \"'Cause we all have wings\" \"But some of us don't know why\" \"I was standing\" \"Hey.\" \"", "Grab some skates from the rental shack.\" \"", "No, no, I wasn't planning on skating today.\" \"", "I wasn't planning on doing that routine in front of you so I guess the day has other plans for both of us.\" \" ", "Don't throw that.\" \" ", "Go with it.\" \"", "I'm just gonna wa...\" \"Well, I can't reach that.\" \"", "I'll watch.\" \"", "Come on.\" \"", "All right.\" \"", "All right.\" \"", "Stay in the car, Phillip.\" \"", "Stay in the car.\" \"", "Wow.\" \"", "Nice.\" \" ", "Little mood lighting, huh?\" \" ", "What are you waiting for?\" \" ", "You can skate, can't you?\" \" ", "Of course I can skate.\" \"", "Yeah.\" \" ", "Oh, no, no.\" \"", "Oh.\" \" ", "Aah!\" \"", "Oh, that hurts.\" \" ", "Are you okay?\" \" ", "Oh.\" \"", "I forgot how much fun this is.\" \" ", "Oh.\" \" ", "Oh, God.\" \"", "Oh, dear.\" \" ", "Welcome.\" \" ", "Ha, ha.\" \"", "You really are a mess, aren't you?\" \" ", "Yeah, I am.\" \" ", "Ha-ha-ha.\" \"", "You're not catching me at my best.\" \"", "Do you miss him?\" \"", "Do I miss my dad?\" \" ", "Yeah.\" \" ", "Yeah.\" \"", "Yeah, I miss my dad.\" \"", "And he did happen to die at a time when life is kind of messy.\" \"", "I mean, I don't know if I would've talked to him about any of it but there's something nice about knowing that he was out there, you know?\" \"", "Yeah.\" \"", "Ah.\" \"", "Have you ever been up to Maine, Penny?\" \"", "Ha, ha.\" \"", "What?\" \"", "Heh.\" \"", "Sorry, just go with it.\" \"", "You ever been up there?\" \"", "Um...\" \" I've been to Cape Cod.\" \"", "Does that count?\" \" ", "It does, yeah.\" \"", "For as long as I can remember, every time I drive on the interstate I would always think:\" \"If I just keep heading north, I can get to Maine, right?\" \"", "Honestly, it doesn't need to be Maine specifically I suppose, but just any place new, right?\" \"", "And I never have.\" \"", "I've never taken any chances.\" \"", "I've spent my entire life playing it safe just to avoid being exactly where I am right now.\" \"", "Well, you know where you are right now?\" \"", "Right now you're in a cool rink on a hot day listening to a Cyndi Lauper classic under some disco lights.\" \"", "Cut yourself some slack, Judd.\" \"", "Anything can happen.\" \"", "Anything happens all the time.\" \"", "Time after time\" \"Time after time\" \"Time after time\" \"Time after time\" \"Sorry I'm late.\" \"", "You're a dick.\" \"", "Yeah, tell me something I don't know.\" \"", "Your shirt's on inside out.\" \"", "That, I did not know.\" \"", "Hi.\" \"", "I'm so sorry to show up unannounced like this, but I've been trying to call.\" \" ", "I wish you would've told me.\" \" ", "What do you want?\" \"", "Smells like dead fish in here.\" \"", "Don't worry about that.\" \"", "You're gonna be leaving soon.\" \"", "Please, Judd.\" \"", "Do you think it was easy for me to come here?\" \"", "I need to talk to you.\" \"", "What do you possibly have to say here?\" \"", "Are you and Wade getting married?\" \"", "Is that it?\" \"", "Are you sick or something?\" \"", "I'm something, all right.\" \"", "You can't possibly know that it's mine.\" \"", "It's yours.\" \"", "Trust me.\" \"", "Well, strangely, trust is not the first impulse I have when it comes to you.\" \"", "So it turned out Wade is sterile.\" \"", "I thought you might like that.\" \" ", "Sterile.\" \" ", "Mm-hm.\" \"", "Hmm.\" \"", "Couldn't have been too happy about this.\" \" ", "It was a blow, but he's being supportive.\" \" ", "What a guy.\" \"", "Judd.\" \"", "We were never the same after we lost our baby.\" \"", "Hang on.\" \"", "You're not gonna use our miscarriage as an excuse for fucking my boss, are you?\" \"", "No.\" \"", "That's not what I'm saying.\" \"", "That sounds like what you're loading up.\" \"", "I'm saying that we were never the same after that.\" \"", "You just shut down, like always.\" \"", "Look, I know that it's not how we imagined it, but we can do this, can't we?\" \"", "I mean, lots of divorced people raise their children together.\" \"", "I know it's complicated.\" \"", "Hmm.\" \"", "And I don't do complicated.\" \"", "What?\" \"", "Nothing.\" \"", "This is happening, Judd.\" \"", "You're going to be a father.\" \"", "Ah.\" \"", "I don't know.\" \"", "I guess I was expecting your reaction to be a bit more...\" \" I don't know.\" \" ", "A bit more what?\" \"", "Last time I saw you, you were in our bed with my boss.\" \"", "Tough image to process.\" \"", "Still working on that.\" \"", "And then you drop this bomb on me?\" \"", "You might have to give me a minute on this one.\" \"", "Okay?\" \"", "You're right.\" \"", "I checked into the Marriott for a few days.\" \"", "So, um...\" \"Please come talk to me when you're ready, okay?\" \"", "Hi, Phillip.\" \"", "Quinn.\" \"", "I always knew there was something of a cold-hearted slut in you.\" \" ", "Takes one to know one.\" \" ", "Touché, pussycat.\" \"", "So?\" \"", "What are you guys talking about?\" \" ", "Nothing.\" \" ", "I'm pregnant.\" \"", "Mazel tov?\" \"", "This is one of those tricky situations where you need someone to talk to or wanna be left alone.\" \"", "It'd be a great help if maybe you can let me know...\" \" Go away, please.\" \" ", "Okay.\" \"", "Um...\" \"I'll be on the other side.\" \"", "Wow.\" \"", "Judd Altman on my front steps.\" \"", "Have a rough day?\" \"", "Yup.\" \"", "You could say that.\" \"", "You wanna talk about it?\" \"", "No.\" \"", "That okay?\" \"", "It's okay.\" \"", "Yeah.\" \"", "I don't know why I'm here, but, um I could not think of one place I would rather be more.\" \"", "You coming in?\" \"", "Should I?\" \"", "I would.\" \"", "Laundry room.\" \"", "Laundry.\" \"", "Keep going.\" \"", "Hi.\" \"", "Horry.\" \"", "Hey, Sunflower.\" \"", "What are you doing?\" \"", "I don't know.\" \"", "You don't know?\" \"", "I went to the garage to get this wrench.\" \"", "Least I think it was the wrench I was after.\" \"", "But now I'm up here and I can't remember why.\" \"", "Well, I'm sure it'll come to you.\" \"", "No, it won't.\" \"", "Please.\" \"", "Come on.\" \"", "Sit.\" \"", "It's okay.\" \"", "Horry.\" \"", "Do you hate me?\" \" ", "No.\" \" ", "Not ever?\" \"", "Not ever.\" \"", "Because I would.\" \"", "I should never have left.\" \"", "I never would've let you stay- You were 20 years old.\" \"", "I wasn't gonna be the guy who kept you here.\" \"", "After I had the accident...\" \"After we had the accident.\" \"", "I was in the car with you.\" \"", "Right?\" \"", "I know.\" \"", "I was different afterwards.\" \"", "I had this anger.\" \"", "I couldn't control it.\" \" ", "That night in the kitchen...\" \" You weren't yourself.\" \"", "I'm still not.\" \"", "Don't be freaked out.\" \"", "I'm not.\" \"", "You're definitely freaking out.\" \"", "How do you know?\" \"", "You can't even see me.\" \"", "Oh, I see you, Judd Altman.\" \"", "I've always seen you.\" \"", "So did I hear Serena at like 3 in the morning last night?\" \"", "She was up three times.\" \" ", "Morning.\" \" ", "Good morning.\" \"", "Where's your suit?\" \"", "Why do I need a suit?\" \"", "Apparently we're going to temple.\" \"", "Boner sold Mom on it.\" \" ", "We have to say a prayer for Dad's soul.\" \" ", "Can't do that here, huh?\" \"", "Trust me, I've already asked all the right questions.\" \"", "Oh.\" \"", "Judd, there you are.\" \"", "You didn't tell anyone where you were going yesterday.\" \" ", "Good reason for that.\" \"", "I didn't want to.\" \" ", "Oh, Judd.\" \"", "Everyone, just cut Judd some slack.\" \"", "He's got a lot on his plate.\" \" ", "Careful.\" \" ", "Why?\" \"", "What's going on?\" \" ", "You know, Quinn's pregnant.\" \"", "It's Judd's.\" \" ", "No...\" \"Goddamn it.\" \" ", "Holy shit.\" \" ", "What?\" \" ", "You ever think before you speak?\" \" ", "No, that would take all the fun out of it.\" \"", "This week keeps on getting better and better.\" \"", "Unbelievable.\" \"", "Annie.\" \" ", "Nice.\" \" ", "You coming?\" \"", "No, I think I'm gonna stay back.\" \" ", "Mm.\" \"", "You sure?\" \" ", "I think Annie could use somebody to talk to.\" \"", "You know, sometimes I think you're too good for me.\" \"", "Hmm.\" \"", "Don't be silly.\" \"", "I'm definitely too good for you.\" \"", "Yeah, I would've hung it up if I thought I needed it again, Mom.\" \"", "Sorry.\" \" ", "This was your father's favorite.\" \" ", "Mm.\" \"", "It's very nice.\" \" ", "So.\" \"", "A baby.\" \" ", "Mm-hm.\" \" ", "You must be terrified.\" \" ", "I am.\" \"", "Well, if it's any consolation, that feeling never goes away.\" \" ", "Not really.\" \" ", "Great.\" \" ", "Handsome?\" \" ", "Yeah.\" \"", "Thank you.\" \"", "He was very proud of you, you know.\" \" ", "I wonder what he'd think now.\" \" ", "What do you mean?\" \"", "Come on.\" \"", "My marriage is over.\" \"", "I don't have a job.\" \"", "That's why you didn't come see him these last few weeks.\" \"", "You thought he'd think less of you.\" \"", "I think less of me.\" \"", "I've got nothing.\" \"", "Look at me.\" \"", "I'm way too old to have this much nothing.\" \" ", "Sit down, baby.\" \" ", "It's fine.\" \"", "Seriously.\" \"", "No, let me tell you about your dad.\" \"", "You could've talked to him.\" \"", "He'd have understood.\" \"", "How?\" \"", "He never failed at anything.\" \"", "That was kind of Dad's thing, wasn't it?\" \"", "Oh, God, Judd.\" \"", "Mort would've lost his business years ago if it hadn't been for my royalties and Paul coming in when he did.\" \" ", "Hmm.\" \" ", "Your father was a terrible businessman.\" \"", "He just figured if he had the store, you'd all come work there.\" \"", "He just wanted to be around you.\" \"", "Your father loved you, not what you did.\" \"", "I mean, The Man Up Show?\" \"", "Are you kidding?\" \"", "You've listened to it, right?\" \"", "It's asinine.\" \"", "Heh.\" \"", "No.\" \"", "You were his boy.\" \"", "And as far as he was concerned, the sun rose and set on you and your siblings.\" \"", "Judd.\" \"", "You're gonna be okay.\" \" ", "I know.\" \" ", "No, you don't.\" \"", "But I do.\" \"", "How are you so okay?\" \"", "I think with every passing day I remember your father less as a sick, frail patient and more as that strong, vibrant man I was married to all those years.\" \"", "Also, I'm popping Xanax like Tic Tacs.\" \"", "Go on.\" \"", "Shabbas.\" \"", "Shabbas.\" \"", "Shabbas.\" \"", "Good Shabbas, Elmsbrook.\" \"", "Good Shabbas.\" \"", "What is that?\" \"", "I mean, I feel like this is my shul, right?\" \"", "You feel like my congregation.\" \"", "You don't sound like them, though.\" \"", "How about this?\" \"", "Can I get a Shabbat Shalom?\" \"", "Shabbat Shalom.\" \"", "That's what I'm talking about.\" \"", "What?\" \"", "That's where we should start.\" \"", "You understand?\" \"", "We gotta leaven that bread.\" \"", "But let's take it down for a second.\" \"", "A couple notches.\" \"", "Let's take it down.\" \"", "Now, as many of you know, Mort Altman passed away this past week.\" \"", "His family's joined us here today to mark his passing before God and community.\" \"", "Wendy, how are you?\" \" ", "You look good.\" \" ", "Ew.\" \"", "On a personal note, I grew up in the Altman home.\" \" ", "Oh, shit.\" \" ", "Hanging out with Phillip.\" \"", "Remember?\" \" ", "Playing ball with the boys.\" \" ", "Getting wasted.\" \" ", "Jerking off.\" \" ", "Trying to touch my boobs.\" \"", "And I mourn with them.\" \"", "I do.\" \"", "What do you say we get this party started?\" \"", "Does now feel like the right time?\" \"", "It feels like the right time to me.\" \"", "Cantor Mia.\" \"", "Bring them back up.\" \"", "See you in a bit.\" \"", "Wait.\" \"", "Hey.\" \" ", "Where's he going?\" \" ", "I don't know.\" \"", "Maybe he's sick.\" \"", "I'll go check on him.\" \"", "I'll be right back.\" \" ", "Here.\" \" ", "You've been holding out on me.\" \" ", "What?\" \"", "This?\" \" ", "Where'd you get this?\" \"", "This is Dad's jacket, so...\" \" Dad was a stoner?\" \" ", "No, it was probably medicinal.\" \"", "It always is.\" \"", "Damn.\" \"", "I miss him.\" \" ", "Yeah.\" \" ", "I miss you, Dad.\" \"", "I missed him when he was alive.\" \"", "Remember how he used to do that thing with his forehead?\" \"", "Hmm?\" \"", "The forehead thing.\" \" ", "What you talking about?\" \" ", "It was instead of kissing us.\" \"", "You do remember how he never kissed us.\" \"", "Closest he could get was like, he would, um press his forehead against yours.\" \" ", "I know.\" \" ", "Like this.\" \"", "Let's do it.\" \" ", "Yeah, intimacy was not his thing.\" \" ", "This is intimate.\" \"", "Get away from me.\" \"", "You got one eye.\" \" ", "Ha-ha-ha.\" \" ", "And I can't handle that.\" \" ", "You're fucked up.\" \" ", "That's true, but...\" \"You know the other day when we were doing the memories of him?\" \"", "I couldn't come up with one single memory.\" \"", "Why do you think that is?\" \"", "I don't know.\" \"", "And now you're gonna be a dad.\" \" ", "Just like Dad.\" \" ", "Poor kid.\" \"", "I know you're going through a lot of complex shit right now and granted, this is coming from the family screw-up but I just want you to know I'm on your side.\" \"", "You know, whatever that means I'm on it.\" \"", "Thanks, Phillip.\" \"", "Guys, what the hell?\" \"", "Um...\" \" Cannabis?\" \" ", "You're late for class.\" \"", "Please.\" \"", "Swing low\" \"Sweet chariot\" \"Coming for to carry me home\" \"Please stop that.\" \"", "Come on.\" \"", "Swing low\" \"Sweet chariot\" \"Coming for to carry me\" \"Home\" \"Oh, man.\" \"", "I used to be so much fun.\" \"", "I don't know what happened.\" \"", "I'll tell you what happened.\" \"", "I stayed.\" \"", "Man, you guys, you went off.\" \"", "You had your little adventures.\" \"", "And I held down the fucking fort.\" \"", "Because somebody had to, and now I'm not fun anymore.\" \" ", "Do you wanna tell him, or should I?\" \" ", "No, I got this.\" \"", "You were never any fun.\" \" ", "Really?\" \" ", "Paul, I love you to death, but you sucked.\" \"", "Mm-hm.\" \"", "I was constant, at least.\" \" ", "Constant click.\" \" ", "Thank you.\" \"", "Oh, shit.\" \"", "We should get going.\" \"", "Mom sent me to get you guys a while ago.\" \"", "We're in temple, for chrissake.\" \"", "How much trouble does she think we're gonna get into in temple?\" \"", "That is the fire alarm.\" \"", "That is the real fire alarm.\" \"", "So as a community, let's all get up and make our way to the exits.\" \"", "Right by the reader.\" \"", "Let's go.\" \"", "This probably isn't gonna go over very well.\" \"", "Everything is fine.\" \"", "I'm sure it was a false alarm.\" \" ", "Just blend in.\" \" ", "Where would they have gone?\" \"", "Ah...\" \"Oh, my God.\" \" ", "We got it.\" \" ", "What did you do?\" \"", "No.\" \"", "Nobody did anything.\" \"", "We put it out.\" \"", "Hose got away from us, though.\" \" ", "You guys smell like a dorm room.\" \" ", "You got high in temple?\" \"", "No, no, no, please, Mother.\" \" ", "We knocked out a fire.\" \" ", "Who's hungry?\" \" ", "We got it.\" \" ", "What the hell, Phillip?\" \"", "Phillip had nothing to do with it.\" \" ", "It was probably electrical.\" \" ", "It wasn't electrical.\" \"", "Is that weed I smell?\" \"", "Was everybody smoking weed?\" \"", "You smell the fire.\" \"", "Mom smelled the same thing.\" \"", "Yeah, I did.\" \"", "I smelled it.\" \"", "It's not fire.\" \"", "It's weed.\" \"", "You guys were smoking weed, right?\" \" ", "You'd know.\" \" ", "Heh.\" \"", "You know what?\" \"", "How about you just head out before the cops come, okay?\" \" ", "Smart.\" \"", "See you back home?\" \" ", "Thanks, Boner.\" \" ", "You rock.\" \" ", "I swear to God.\" \"", "Don't touch my balls.\" \"", "And secondly, stop calling me that.\" \"", "That was the very last time you'll ever call me \"Boner.\"\" \" ", "Boner, God's watching.\" \" ", "Oh, my God.\" \" ", "Your bones are, like, hollow.\" \" ", "Get off of me.\" \" ", "You're so easy to manipulate.\" \" ", "You're so strong.\" \" ", "I'm sorry, Boner.\" \" ", "Come on.\" \"", "Oh, my God, you guys are so going to hell.\" \"", "Do we believe in hell?\" \"", "Wakey, wakey, sleepyhead-.\" \"", "I was just taking a nap, Mom.\" \"", "What's everyone doing?\" \"", "Hi.\" \"", "I'm not your mom.\" \"", "Annie, what's going on?\" \"", "I feel so bad about how I reacted when I found out that Quinn was pregnant.\" \"", "A simple apology will do.\" \"", "Get your clothes back on.\" \"", "Put those away.\" \" ", "I have been trying to have a baby for years.\" \" ", "Don't go crazy on me.\" \"", "I take my hormones every day.\" \"", "My eggs have tested fine.\" \" ", "I don't like where this is going.\" \" ", "Paul won't get his sperm tested.\" \" ", "No, don't start digging around in...\" \" Be my friend.\" \" ", "What are you doing, Annie?\" \" ", "It will be our secret.\" \" ", "We'll never know if it was you or Paul.\" \" ", "You just crossed the line there.\" \"", "You've lost your mind.\" \"", "You've lost your judgment.\" \" ", "I'm tired, Judd.\" \" ", "Okay.\" \"", "I'm tired of needles.\" \"", "And ultrasounds.\" \" ", "I'll bet.\" \" ", "And having my heart broken every month.\" \" ", "Uncle Judd!\" \" ", "Shit.\" \" ", "Off, off, off.\" \"", "Goddamn it.\" \" ", "Shit.\" \"", "Give me the b...\" \"Hi.\" \"", "I'm making a pishy and a poopie.\" \"", "Okay.\" \"", "Good.\" \"", "Good.\" \"", "And we were just, uh, getting warm.\" \"", "Aunt Annie was super cold and now she's all set.\" \"", "And Uncle Judd's gonna go get a snackie.\" \"", "Judd, I'm...\" \"I don't know how else to explain this to you. ", "if the deal falls apart, it's my ass on the line.\" \" ", "You had a death in the family.\" \" ", "Four days ago.\" \"", "I have to go to London and close the deal.\" \"", "Why are we even having this fight?\" \" ", "I can't even fight with you.\" \"", "I'm sorry.\" \" ", "Oh, my God.\" \" ", "I have to go to London.\" \" ", "Unbelievable.\" \"", "I cannot be gone for seven days.\" \"", "You mean you can't be here for seven days.\" \"", "What are you doing?\" \" ", "Sorry?\" \" ", "Why are you skulking?\" \"", "I'm just, uh, you know...\" \"There it is.\" \"", "I'm looking for gum.\" \"", "Sorry.\" \"", "Continue.\" \" ", "I gotta go, baby.\" \" ", "Jesus Christ.\" \"", "Just go.\" \"", "Stop doing a little play about how you have to go and go already.\" \"", "That's so sweet of you.\" \"", "Thank you.\" \" ", "Hey.\" \"", "Judd, can I ask you something?\" \" ", "Yup.\" \"", "She doesn't really care that I'm leaving, so why is she busting my balls?\" \"", "Uh...\" \"Well, maybe she does care.\" \"", "Heh.\" \"", "I'm an asshole, Judd.\" \"", "I'm not stupid.\" \"", "Take care.\" \"", "You too.\" \" ", "Hi.\" \" ", "Hi.\" \"", "No Barry?\" \"", "Barry's gone.\" \"", "How you doing?\" \"", "I'm fine.\" \"", "Excuse me.\" \" ", "Yes.\" \" ", "You're so not fine.\" \"", "You know, sleeping with your shrink does not technically make you a relationship expert.\" \"", "Yeah.\" \"", "But I am an expert in you.\" \" ", "No, you're not.\" \" ", "Yes, I am.\" \"", "You raised me.\" \"", "You're the voice in my head.\" \"", "Not Mom.\" \"", "It's not Dad.\" \"", "You.\" \" ", "Really?\" \" ", "Yeah.\" \"", "And sometimes I just wish you would shut the fuck up.\" \"", "What do you want'?\" \"", "What do you want?\" \"", "I just want you to know it's okay to be fine.\" \"", "That you deserve to be fine.\" \"", "Thank you.\" \"", "You're welcome.\" \"", "Will you carry this?\" \"", "Oh, God.\" \"", "Holy shit.\" \"", "Oh, how dare you.\" \"", "That is not cool.\" \"", "I will pants you from up here.\" \" ", "You do not get to say I'm heavy.\" \" ", "No more pizza.\" \"", "Don't make me stand next to your girlfriend for seven days-..\" \"...and then fucking say I'm heavy.\" \"", "Hi, Judd.\" \"", "Look.\" \"", "I am really sorry about the other day.\" \"", "I just hope that you'll come by and see me.\" \"", "I'm in Room 346.\" \"", "So please, uh...\" \"Bye.\" \"", "Morning.\" \"", "Do you ever sleep?\" \"", "Heh.\" \"", "Not lately.\" \"", "So.\" \"", "Horry. ", "huh?\" \"", "Are you surprised?\" \"", "The single advantage of being me nowadays is it's very hard to surprise me.\" \"", "So no.\" \" ", "I'm not Quinn, Judd.\" \" ", "I know.\" \" ", "Please don't look at me like I'm Quinn.\" \" ", "I'm not.\" \"", "This is different than your thing.\" \"", "This is not like your thing.\" \"", "Heh.\" \"", "I get it.\" \"", "We were so in love, Judd.\" \"", "And now he's alone.\" \"", "He's, like, permanently alone.\" \"", "And Barry is just...?\" \"", "I will never love Barry the way that I loved Horry.\" \"", "And I will never love anybody else like that.\" \"", "Ever.\" \"", "I would not do that to Horry.\" \"", "Is it the whole world, or is it just this family?\" \"", "You and Barry.\" \"", "And me and Quinn.\" \"", "And Phillip and Tracy.\" \"", "And Paul and Annie.\" \"", "No one is happy.\" \"", "The one person that's got it figured out in this family is Cole.\" \"", "You know, he sits on that can and he takes his dump, and he's super happy.\" \" ", "Ha, ha.\" \" ", "You show me one happy adult.\" \"", "Everybody's sad or angry or lying or cheating.\" \"", "I think Quinn's pregnancy is just freaking you out.\" \"", "Yeah, it's freaking me out.\" \"", "Three months ago I had a great job and a nice apartment and I was in love with my wife.\" \" ", "No, you weren't.\" \" ", "No?\" \"", "No.\" \"", "She was sleeping with somebody else for a year and you never noticed.\" \"", "How in love could you have been?\" \"", "Yep.\" \"", "That's fair.\" \"", "Sure like to think I could still do that, though, with someone.\" \"", "That I can just find someone and fall in love and have it last.\" \"", "That seems impossible to me right now.\" \"", "Love causes cancer.\" \"", "Like everything else.\" \"", "But it's still love.\" \"", "It has its moments.\" \"", "I had a moment with Penny the other night.\" \" ", "Really?\" \" ", "Yeah.\" \"", "Really?\" \"", "Starting to do complicated.\" \"", "You proud of me?\" \"", "Well, I don't know.\" \"", "How does it feel?\" \"", "Complicated.\" \"", "I mean, that's the gist of it.\" \"", "But, you know.\" \"", "Anyway.\" \"", "How you doing, Uncle Joe?\" \" ", "This is Trish.\" \" ", "Hi, everyone.\" \"", "By the way, we're sleeping together.\" \" ", "Mazel.\" \"", "Ha-ha-ha.\" \"", "Mom.\" \"", "Why is Paul allowed to miss this?\" \" ", "Trish is a nurse.\" \" ", "Retired.\" \"", "He had a call.\" \"", "She still wears her uniform sometimes, if you take my meaning.\" \" ", "Honey, I think the baby's waking up.\" \" ", "The baby's in the kitchen with Linda.\" \" ", "Oh!\" \" ", "Then who am I hearing?\" \" ", "Are you hard?\" \"", "Are you hard?\" \" ", "Jesus Christ, Annie.\" \"", "Put it in me.\" \" ", "Oh, crap.\" \"", "I left the baby monitor on upstairs.\" \" ", "I'll get it.\" \"", "There you go.\" \"", "Sorry about that, everyone.\" \" ", "Put your dick in me.\" \" ", "Where was it before?\" \"", "Oh, do it.\" \"", "Do it, Paul.\" \" ", "Turn it off.\" \" ", "Turn it up?\" \" ", "Stop talking, sweetie.\" \" ", "Turn it up.\" \" ", "It feels so good.\" \" ", "Stop talking.\" \"", "Come on, people.\" \"", "It's just sex.\" \" ", "Sweetie.\" \" ", "What?\" \" ", "Shut up.\" \" ", "Okay.\" \" ", "He just told her to shut up.\" \" ", "Okay, he's slowing down.\" \"", "No, this is good.\" \"", "He's too fast anyway.\" \"", "It's the circle of life, everybody- Let's go, Altman's.\" \"", "Yes.\" \"", "I can feel you.\" \"", "I can feel it.\" \"", "Yes.\" \"", "You're so hard.\" \" ", "Come!\" \"", "Come now!\" \"", "Coming!\" \"", "Come!\" \" ", "Ha-ha-ha.\" \"", "Linda, thank you.\" \"", "There we go.\" \"", "There we go.\" \"", "Oh, do it.\" \"", "It has a backup battery.\" \" ", "Put a baby in me, Paul.\" \" ", "That's a nice feature.\" \"", "Shove a baby up there!\" \"", "Shove a bab...!\" \"", "Oh.\" \" ", "What is wrong with you?\" \" ", "I'm ashamed.\" \"", "Save money, everybody.\" \"", "Free of charge.\" \"", "Enjoy.\" \"", "It was just incredibly awkward, and it just didn't stop.\" \"", "Oh, my God.\" \"", "And everybody heard?\" \"", "Yeah.\" \"", "I like when you laugh.\" \" ", "I like that you like it.\" \" ", "Yeah.\" \"", "You know that this is the worst possible time this could be happening, Penny?\" \"", "I know, but I'm gonna kiss you anyway.\" \"", "You're so good at that.\" \" ", "You're very easily pleased.\" \" ", "Is that a crime?\" \"", "You should try it sometime.\" \" ", "Hello.\" \" ", "Judd.\" \"", "Something's wrong.\" \"", "I'm bleeding.\" \"", "What do you mean, you're bleeding?\" \"", "How much?\" \"", "A lot.\" \"", "I'm gonna lose this one too.\" \"", "I don't know what to do.\" \"", "I'm gonna hang up.\" \"", "I'm gonna call an ambulance.\" \"", "I want you to stay calm.\" \"", "Okay?\" \"", "I'm gonna hang up right now.\" \"", "Hi, there is a pregnant woman having problems at the Renaissance just off Route 100.\" \"", "She's in Room 346.\" \"", "Yeah.\" \"", "Okay.\" \"", "Yes, this number's fine.\" \"", "Thank you.\" \" ", "Quinn's pregnant?\" \" ", "Yeah.\" \"", "And it's yours?\" \"", "You gotta go.\" \"", "Penny, this is something I wanted...\" \"No.\" \"", "It's fine.\" \"", "There's a pregnant woman.\" \"", "She's bleeding.\" \"", "You gotta go.\" \"", "Yeah.\" \"", "Yeah.\" \"", "I'll talk to you tonight.\" \"", "Hi.\" \"", "How you doing?\" \"", "Are you okay?\" \" ", "There's no heartbeat.\" \" ", "There's no heartbeat?\" \" ", "I can't believe this is happening again.\" \" ", "Take it easy.\" \" ", "Nothing is happening again.\" \"", "Okay?\" \" ", "I deserve this.\" \"", "I do.\" \"", "I ruined us.\" \" ", "Please.\" \"", "We're not doing that here.\" \" ", "Quiet.\" \"", "What's that?\" \" ", "There's your baby's heartbeat.\" \" ", "Okay.\" \"", "All right.\" \"", "Baby was just in a weird position, huh?\" \"", "Mm-hm.\" \" ", "Okay.\" \"", "That's our baby.\" \"", "Hey, I got here as quick as I could.\" \"", "My GPS was...\" \"Sorry about that.\" \" ", "Are you okay?\" \" ", "Oh.\" \"", "Yeah.\" \" ", "Mm-hm.\" \" ", "You had me so scared.\" \" ", "Oh.\" \" ", "Made a couple calls, huh?\" \"", "You all right?\" \"", "What happened?\" \"", "Hello, hello, hello.\" \"", "Dr. Rausch.\" \" ", "Mr. and Mrs. Altman?\" \" ", "I'm Mr. Altman.\" \"", "And you are?\" \"", "That's just a guy that Mrs. Altman was fucking.\" \"", "Uh-huh.\" \" ", "In my bed.\" \"", "Judd, please, not now.\" \"", "You just walk out on everyone at the station, grow a beard and now you're a smart-ass?\" \"", "Wade Beaufort.\" \"", "It's complicated.\" \"", "Well, I'll simplify it.\" \"", "Both of you get out of my exam room.\" \" ", "Really?\" \" ", "Yeah.\" \" ", "You got us kicked out.\" \" ", "And you too, sir.\" \" ", "Here we go.\" \" ", "I'll be in the waiting room.\" \"", "So.\" \"", "That should do it, right?\" \"", "I didn't sign, because I think my wife...\" \"Or the patient should sign right there.\" \"", "There you go.\" \"", "Is that where she should sign?\" \"", "I'll just leave that here.\" \"", "Don't be a goddamn baby, Judd.\" \"", "I extend an olive branch, and you're gonna pitch it in the trash?\" \"", "You're not gonna stay with her.\" \"", "We know that.\" \"", "The only person that doesn't know is Quinn.\" \"", "That's what's gonna happen?\" \"", "You're clairvoyant?\" \"", "You know what's going on?\" \"", "I don't need to listen to your crap.\" \" ", "You don't know what you're talking about.\" \" ", "It's the Man Up guy.\" \"", "What's up, dudes?\" \"", "You don't know me.\" \"", "What are you talking about?\" \"", "Is there another waiting room with more chairs?\" \" ", "I don't know you?\" \" ", "No.\" \"", "I've been with you for seven years.\" \"", "Don't tell me I don't know you.\" \"", "And I know you'll fuck just about anyone who'll have you.\" \"", "That's interns.\" \"", "That's sales reps.\" \"", "That's sponsors.\" \"", "So don't tell me you're not already drawing up plans for the quickest exit.\" \"", "You're logging all the ass I'm crushing, and I'm the perv?\" \"", "Hey, fellas.\" \"", "We got some young boys here.\" \"", "Scoutmaster.\" \"", "Park it.\" \"", "We're in the middle of something.\" \"", "I didn't fuck her any more than she fucked me.\" \" ", "It takes two to tango, all right?\" \" ", "That's a separate situation that I'll deal with.\" \" ", "That's a party for two.\" \" ", "Don't worry about her.\" \"", "We're talking about you.\" \"", "Take this discussion outside.\" \" ", "Sorry.\" \" ", "What's going on, Judd?\" \" ", "Listen to me.\" \"", "She fucked me.\" \" ", "Yeah, I heard you the first time.\" \" ", "Stop it, you guys.\" \" ", "Judd.\" \"", "Really?\" \"", "Look who's gonna man up now.\" \"", "Everybody just be quiet!\" \"", "Now, we just are all gonna just take a beat here.\" \"", "I'm not fighting.\" \"", "Who the fuck are you coming in here with this middle part at your age barking orders at everyone?\" \"", "Who the hell am I?\" \"", "I'm Wendy Altman, bitch.\" \" ", "Ow.\" \"", "Shit.\" \" ", "That's what happens.\" \"", "Yeah.\" \"", "That's a fucking princess cut.\" \"", "You fucking clown.\" \" ", "Are you kidding me?\" \" ", "Dick.\" \"", "You have your pussy...\" \"You have your sister hit me?\" \"", "Yep.\" \"", "And I got her purse.\" \"", "Oh, yeah, walk me out because I'm so dangerous.\" \"", "Like, a mother of two with diapers in my purse.\" \"", "Here's the parking lot.\" \"", "Thank you.\" \"", "I can find my way now.\" \"", "Thank you.\" \" ", "Great work, officers.\" \" ", "Nice hats.\" \"", "Oh.\" \"", "I just got a great idea.\" \"", "Let's stop acting like crazy people.\" \" ", "Yeah.\" \"", "I agree.\" \" ", "I'm gonna get the car.\" \"", "That's a nice parking spot, huh?\" \"", "Is that Wade's car?\" \" ", "That's one of his cars.\" \"", "He's got a few.\" \" ", "He has a few?\" \"", "Think he's compensating for something?\" \"", "Yeah.\" \"", "For having too much money.\" \"", "You know, I heard the baby's heartbeat in there.\" \"", "That's great.\" \"", "Right?\" \"", "I'm gonna have to forgive her for the sake of that kid, aren't I?\" \"", "Well, I'm no expert but I think you're gonna have to make much larger sacrifices down the road.\" \"", "Yeah.\" \"", "That's true.\" \"", "You sounded almost wise there for a minute.\" \"", "Right?\" \"", "All right.\" \"", "You go ahead.\" \"", "I'm gonna meet up with you guys back at home.\" \"", "Hey, sis.\" \"", "That was a great shot.\" \"", "Thanks for the help.\" \"", "Well, you guys are idiots.\" \"", "But you're my idiots.\" \"", "Drive safe.\" \"", "Are you kidding me?\" \"", "It's 2014.\" \"", "Okay?\" \" ", "There they go.\" \" ", "Later, man.\" \"", "Take it easy.\" \"", "Uh, fellas, before you go...\" \"You see this nice car here?\" \"", "I've got $43 that says you can't flip it over.\" \" ", "Man, what'd he do to you, anyway?\" \" ", "He slept with my wife.\" \" ", "What do you say?\" \" ", "Keep the money, bro.\" \" ", "Let's do it.\" \" ", "Really?\" \" ", "Come on, boys.\" \"", "Do it.\" \"", "Really.\" \" ", "Oh, boy.\" \" ", "Bend your knees.\" \" ", "Come on.\" \"", "There it goes.\" \"", "You got it!\" \"", "Ha-ha-ha.\" \"", "Whoo!\" \" ", "That was good.\" \" ", "Later, dude.\" \"", "Very nice.\" \" ", "Are you serious?\" \" ", "Come on, man.\" \"", "Get out of here.\" \"", "I did not expect that from you.\" \"", "You know, the saddest thing about this whole mess is you were one of my only real friends.\" \"", "I was your employee.\" \"", "Even sadder.\" \"", "Look, bud, um, I'm sorry how this whole thing shook out.\" \"", "You know, I'm looking at you up there with her, and there's a baby on the way.\" \"", "She's in there bawling about a heartbeat, and, buddy, I don't even hear it.\" \"", "I don't even think the doctor hears it.\" \"", "I think they're all in on this thing.\" \"", "And they're getting all emotional, and it's just not me.\" \"", "I mean, I sure as shit aren't a stepfather.\" \" ", "So is that it?\" \"", "Are you done?\" \" ", "I'm out.\" \" ", "That's it?\" \" ", "That's right.\" \" ", "It's what's best for everyone.\" \" ", "You mean it's what's best for you.\" \"", "That's just a coincidence.\" \"", "I don't think that's drivable.\" \"", "I'm gonna take myself a long walk.\" \"", "And thanks.\" \"", "For what?\" \"", "Up until just now, I thought I was the most pathetic guy I knew.\" \"", "You're welcome.\" \"", "It really hurts when you punch someone.\" \"", "Thank God this was platinum.\" \"", "If this was white gold, I would've broken my hand.\" \" ", "It makes me feel terrible.\" \" ", "It was worth it.\" \"", "Like what I'm going through doesn't matter.\" \" ", "I have got...\" \" I'm done.\" \"", "Never mind.\" \"", "What was that?\" \"", "It's just a slight disagreement.\" \" ", "Well, do you wanna talk about it?\" \" ", "Uh...\" \"No, thanks.\" \"", "I have a headache.\" \"", "I'm gonna go lie down.\" \"", "Well, what about shiva?\" \"", "I'm calling it tonight on account of rain.\" \"", "Quinn?\" \"", "I'll be right back.\" \"", "Well...\" \"This is the part where you get to say you were right.\" \"", "You were right.\" \"", "We got lost.\" \"", "I got lost.\" \"", "I got lost.\" \"", "But our baby, he will never be alone.\" \"", "I promise you that.\" \"", "You were right.\" \"", "We don't need to be married to be parents together.\" \"", "I'll be right in there with you.\" \" ", "She.\" \" ", "What?\" \"", "She.\" \" ", "She.\" \" ", "She.\" \"", "I can't believe he's really gone.\" \"", "I know, honey.\" \"", "These are actually pretty comfortable.\" \" ", "Yeah?\" \" ", "Mm.\" \"", "Mm.\" \"", "Oh.\" \"", "Morning, Tracy.\" \"", "I didn't know anyone else was up.\" \" ", "I didn't mean to intrude.\" \"", "You okay?\" \" ", "That's okay.\" \"", "Mm-hm.\" \" ", "Hey, Judd.\" \" ", "Yep?\" \"", "What would you say the odds are that your brother has had sex with that Chelsea girl while we've been here?\" \"", "I mean, you know, I know he's your brother but I could use a friend here.\" \"", "A little honesty for a change.\" \"", "Just between you, me and the sunrise.\" \"", "The odds are pretty good.\" \" ", "I'm sorry.\" \" ", "It's okay.\" \"", "I am a grown-up person.\" \"", "I am smart and professional.\" \"", "I have my shit together.\" \"", "And your brother is a child who's spent his entire life reeling in the slack as fast as you guys will cut it for him.\" \"", "So, what are you gonna do?\" \"", "I think I'm gonna gather up the tattered remnants of my dignity and say goodbye.\" \"", "That'll crush him, you know.\" \"", "I'll let him keep the Porsche.\" \" ", "Really?\" \" ", "Yeah.\" \"", "I don't think he'll have it for very long.\" \"", "He keeps leaving it unlocked with the keys inside.\" \"", "Someone's just gonna drive off with it.\" \"", "Phillip really isn't built to hold on to things.\" \"", "Tracy, you are not the first woman that's wanted to believe in Phillip.\" \"", "But you are far and away the best one.\" \"", "Thanks.\" \"", "Hi.\" \" ", "Penny.\" \" ", "I gotta go to work.\" \"", "Hang on one second.\" \"", "Let me talk to you.\" \" ", "Quinn okay?\" \" ", "Yes, she's fine.\" \" ", "And the baby?\" \" ", "She's good too.\" \" ", "It's a girl?\" \"", "Congratulations.\" \" ", "Yeah.\" \" ", "Will you talk to me for one second?\" \" ", "What?\" \"", "I wanted to explain earlier.\" \"", "Things got...\" \"I got the phone call...\" \"Hey.\" \"", "Look.\" \"", "I'm a big girl.\" \"", "You know, it's not like we were going steady.\" \"", "It's just sex.\" \"", "No, it wasn't.\" \"", "You know that.\" \"", "You know it was more than sex.\" \"", "No. ", "it wasn't.\" \"", "If it was, then what does that say about you?\" \"", "That's all it was.\" \"", "Hey, Penny.\" \"", "Let me...\" \"Oh, my goodness.\" \"", "So many amazing childhood memories from this place.\" \"", "You smell it?\" \"", "Hey.\" \" ", "Oh, shit.\" \" ", "You've been avoiding me.\" \"", "You grabbed my dick.\" \"", "Okay?\" \"", "That's why I've been avoiding you.\" \" ", "I didn't mean to.\" \" ", "Please.\" \"", "You didn't mean to.\" \"", "What'd you think you were gonna find down there, Annie?\" \"", "I'm sorry, Judd.\" \"", "I just...\" \" I want a baby so badly.\" \" ", "Why don't you think about what you do have?\" \"", "You and Paul.\" \"", "You guys really love each other, don't you?\" \"", "Yes.\" \"", "That's so much harder than having a baby.\" \"", "I mean, it's, you know, damn near impossible.\" \"", "And you'll have a baby, one way or another.\" \"", "But do not screw up your marriage to do it.\" \"", "You're right.\" \"", "I know you're right.\" \"", "I'm just the most pathetic person.\" \"", "No, you're not.\" \"", "That's the last thing I'd call you, Annie.\" \"", "Oh, I can think of some other words that I would use as well.\" \" ", "How about \"determined,\" huh?\" \" ", "Oh, my God.\" \"", "Someone came down here very determined.\" \"", "Whoa, whoa, whoa.\" \"", "What's going on?\" \"", "The irony here is that you made a fool out of me.\" \"", "No, I didn't.\" \"", "Wait.\" \"", "Why is that ironic?\" \"", "That fact that he doesn't know why it's ironic is ironic.\" \"", "I gotta go.\" \"", "Thank you all so much.\" \" ", "We can have a conversation about this.\" \" ", "We've had the conversation already.\" \" ", "I wanna have it again.\" \" ", "I saw this coming.\" \"", "He can wait for one second.\" \" ", "Scale of 1 to 10.\" \" ", "Shut up.\" \" ", "Was it how you remembered?\" \" ", "Oh, my God.\" \" ", "Annie?\" \" ", "Hey, buddy.\" \" ", "What the hell's going on here?\" \" ", "We're just having a talk.\" \"", "Your marriage goes to shit, now you're hitting on my wife.\" \"", "Don't think I don't see you look at her.\" \" ", "Don't come over here.\" \" ", "You have wanted to do this for years.\" \"", "Come back here!\" \" ", "Put your suitcase down and talk to me.\" \" ", "I need to go.\" \" ", "Move.\" \"", "Move.\" \" ", "Get back here.\" \"", "We're not done.\" \"", "No, goddamn it!\" \"", "Stop!\" \" ", "Get off me.\" \"", "Get off me.\" \" ", "Paul!\" \" ", "Oh, yes!\" \"", "Stop.\" \"", "Please.\" \"", "Let's just talk about this.\" \" ", "I saw it with my own eyes.\" \" ", "Stop it!\" \" ", "Nothing happened!\" \" ", "Nothing happened!\" \" ", "Your brothers can't fight for shit.\" \" ", "No.\" \"", "It's kind of embarrassing, actually.\" \" ", "Will you two get in there and stop this?\" \" ", "Are you kidding?\" \"", "This is amaz...\" \"Ow!\" \" ", "Stop fighting me.\" \" ", "Get him off of me!\" \"", "If it gets to the point where I think you're being idiots, you're probably being idiots.\" \" ", "Stop.\" \"", "Stop it.\" \"", "What's going on?\" \" ", "He kissed my wife.\" \" ", "No, I didn't.\" \" ", "No, he didn't.\" \"", "Paul.\" \"", "Nothing happened.\" \"", "Could you not get in the car till we work this out?\" \"", "It would never have worked, Phillip.\" \"", "You're a narcissist with Oedipal issues.\" \" ", "I'm a classic enabler.\" \" ", "But I love you.\" \"", "Ow.\" \" ", "I need an adult\" \" I am an adult!\" \" ", "Oh, God.\" \" ", "Stop that.\" \"", "Get off!\" \" ", "Damn it, I'm talking to you.\" \" ", "No, stay on him.\" \"", "Since when have you run away from discussions?\" \" ", "Stop it!\" \" ", "Get back here.\" \"", "We're not done.\" \"", "You love discussions!\" \" ", "Stop it!\" \"", "Stop it!\" \" ", "Oh, my God.\" \" ", "If I get wet, you are dead.\" \" ", "No.\" \"", "No.\" \"", "Somebody stop him.\" \" ", "Boner!\" \"", "Boner!\" \" ", "Unbelievable.\" \"", "Judd.\" \" ", "You can let go any time you want.\" \" ", "No.\" \" ", "You can let go.\" \" ", "Can we stop being a reality show?\" \"", "I don't care.\" \"", "You think you can hurt me any more than I already am?\" \"", "Leave it alone.\" \"", "What the fuck?\" \"", "I guess this is as good a time as any.\" \"", "Did you guys not know about that?\" \"", "Linda was helping me take care of your father.\" \"", "Long, hard nights, huh?\" \"", "I don't know how to explain how it happened.\" \" ", "Did Dad know?\" \" ", "Of course.\" \"", "Your father was a very enlightened man, sexually speaking.\" \"", "Let me tell you a story about your father.\" \" ", "Don't.\" \" ", "I wish you wouldn't.\" \"", "When Horry got hurt and I was drowning in medical bills your father paid our mortgage for a full year so we wouldn't lose the house.\" \"", "Your father was like family to me.\" \"", "And he died knowing your mother wouldn't be alone.\" \"", "Why didn't you tell us?\" \"", "You needed to mourn your father without any distractions.\" \"", "Uh, wait a minute, Mom.\" \"", "This whole shiva thing.\" \"", "It wasn't Dad's idea, was it?\" \"", "Smart boy.\" \" ", "Oh, Mom.\" \" ", "How could you lie to us like that?\" \"", "You wouldn't have stayed if I didn't.\" \"", "And I needed you all here.\" \"", "And you needed each other, even if you couldn't see it.\" \"", "If we didn't come here, Tracy wouldn't have broken up with me.\" \"", "So thank you for ruining my life.\" \"", "I think it's time you took some small measure of responsibility for where you choose to put your own penis.\" \"", "Could you please not talk about my penis?\" \"", "I can't begin to tell you how creepy it is.\" \"", "When he was little he thought it was a Tootsie Roll.\" \"", "You remember that?\" \"", "I used to see him over and try to ah, ah...\" \"No, no, no!\" \" ", "La, la, la Phillip.\" \"", "Phillip.\" \"", "Hey, Phillip.\" \"", "That's terrible to listen to.\" \"", "Take a seat.\" \"", "Take a seat, pal.\" \"", "I get it.\" \"", "This is a private moment.\" \"", "Unless you wanna talk more about Phillip's Tootsie Roll and the way he licks it.\" \"", "So I am gonna head out.\" \"", "Okay?\" \"", "That's it for me.\" \"", "Have a good one.\" \" ", "See you, Boner.\" \" ", "Are you kidding me with that?\" \" ", "Was it you?\" \" ", "Yeah.\" \"", "All right.\" \"", "So, again...\" \"No, no.\" \"", "No.\" \"", "No.\" \"", "Goddamn it.\" \"", "Okay, J, come on.\" \"", "Hey.\" \"", "Hey.\" \"", "You just took a spill.\" \"", "That's all.\" \"", "Okay, buddy?\" \"", "There you go.\" \"", "There you go.\" \"", "Now give me a smile.\" \"", "Okay?\" \"", "Okay, J.\" \"You're okay.\" \"", "Wah, wah.\" \"", "Okay.\" \"", "Judd, honey.\" \"", "Judd.\" \"", "Judd.\" \"", "Judd.\" \"", "Judd.\" \"", "Oh, God.\" \"", "Thank God.\" \"", "You scared me to death.\" \"", "Are you all right?\" \"", "Go ahead.\" \"", "J\" \"Dad, when I was little, he used to call me J.\" \"I remember.\" \"", "I remember.\" \"", "I know.\" \"", "I'm so glad you're okay.\" \"", "I'm so glad you tightened this.\" \" ", "Hi.\" \" ", "You're not allowed on the ice in shoes.\" \" ", "I just wanna say something and then I'll go.\" \" ", "Judd.\" \"", "My mom is in love.\" \"", "Well, that's nice for her.\" \"", "The specifics are very hard to explain.\" \"", "Um, very, very hard.\" \"", "But I realized something.\" \"", "I have never been in love.\" \"", "Not like that.\" \"", "I've been too busy chasing this idea that I had about this perfect life and life is not perfect.\" \"", "It shouldn't be perfect.\" \"", "It should be unpredictable and irrational and complicated.\" \"", "And I want a complicated life where I can love someone like that.\" \" ", "Judd...\" \" And, now, listen.\" \"", "I don't know if things would ever work out between us.\" \"", "I'm emotionally inept, and you're a little strange.\" \"", "You know, right?\" \"", "A little bit.\" \"", "But you're a great strange.\" \"", "You're honest.\" \"", "And you're so...\" \"You're good.\" \"", "And I think that maybe someday we could love each other like that.\" \"", "And I'm sorry that I hurt you.\" \"", "I didn't mean to.\" \"", "Where do you go from here?\" \"", "I don't know.\" \"", "I don't know.\" \"", "Six months, I'm gonna be a dad.\" \"", "And I've never been alone, so I was thinking that I would try that.\" \"", "Well, you know I'm not a fan of small talk, so I'm gonna give you a hug and wish you Godspeed.\" \"", "Be good, Judd Altman.\" \"", "Bye, Penny.\" \"", "And love, love, love\" \"Is only heaven away\" \"Inside you the time moves\" \" Oh, my God.\" \"", "That was some speech.\" \" ", "Thanks.\" \"", "That was amazing.\" \"", "I love the part where you said I was strange.\" \"", "I did say that, didn't I?\" \"", "I was hoping I heard myself wrong.\" \"", "Was that all right?\" \"", "So when you get your act together, you should call me.\" \" ", "Yeah.\" \"", "Did I not say that?\" \" ", "No.\" \"", "I didn't say I'm calling?\" \"", "No.\" \"", "You just were like, I'm weird, but we could still be good together.\" \"", "And we could love each other.\" \"", "You know, you want your alone time for six months.\" \" ", "Walk around, maybe get to think about things.\" \" ", "Definitely meant to say I'm calling in six months.\" \"", "It was the whole reason to come here.\" \"", "I'm so sorry.\" \"", "Hmm.\" \"", "They're playing our song.\" \"", "Yeah, does Cyndi Lauper have to be our song?\" \"", "Lying in my bed I hear the clock tick And think of you\" \"Caught up in circles Confusion is nothing new\" \"It's okay to cry, honey.\" \"", "Or laugh.\" \" ", "There's no correct response.\" \" ", "I know, Mommy.\" \" ", "Mwah.\" \" ", "Stay in touch, okay?\" \"", "Sissy, my turn, my turn, my turn.\" \"", "Oh, yeah.\" \"", "Buckle that good.\" \"", "Is it buckled?\" \"", "Okay, good.\" \" ", "Bye, Wendy.\" \" ", "Bye, Annie.\" \"", "All right.\" \"", "Drive safe.\" \"", "I love you, Judd.\" \"", "Are you gonna be okay with those two little kids on the plane?\" \"", "Deflecting emotion with logistics.\" \"", "Nice.\" \"", "Well, it's what we do.\" \"", "I'm gonna come in when the baby's born.\" \" ", "You keep me posted.\" \" ", "I will.\" \" ", "No, you won't.\" \"", "But I'm coming anyway.\" \" ", "Heh.\" \" ", "Goodbye.\" \" ", "I'll see you soon, Dad.\" \" ", "Mm.\" \" ", "Heh.\" \"", "And then there were three.\" \"", "So Mom just wakes up one morning and decides she's a lesbian.\" \"", "Yeah, it's been that kind of week, hasn't it?\" \"", "So...\" \" Phillip.\" \" ", "Needs a job.\" \" ", "You need a job.\" \" ", "I'll be okay.\" \"", "Do you really believe that?\" \"", "I'm getting there.\" \"", "Dad always had a soft spot for him, didn't he?\" \"", "I think he liked us because we were kind of like him.\" \"", "He likes Phillip because he was nothing like him.\" \"", "Okay, I'll bring him into the business.\" \" ", "Yeah?\" \" ", "Yeah.\" \"", "Oh, Paul.\" \"", "You are a good guy.\" \"", "The secret's out.\" \"", "He's the good brother.\" \"", "Very cool of you.\" \"", "Thank you.\" \"", "Okay, okay.\" \"", "Before you get too excited, here's the deal:\" \"When it comes to Phillip screwing up, like he will you and I are partners, 50-50.\" \" ", "Okay?\" \" ", "That is a deal.\" \"", "You got it.\" \"", "Have you guys tried this kugel?\" \"", "It's terrible.\" \"", "Ha-ha-ha.\" \"", "Oh, shit, I just spit in the kugel.\" \" ", "I'm gonna live to regret this, aren't I?\" \" ", "Of course you are.\" \"", "Let me cut it off the one side.\" \"", "I'll get you some.\" \"", "Slipping away in broad daylight?\" \"", "Yeah.\" \"", "I just wasn't up to the drama of a big goodbye, so...\" \"No, I get it.\" \"", "So Paul offered me the job.\" \"", "Great.\" \"", "I told him I'd mull it over.\" \"", "You know, consider my options.\" \"", "I don't wanna seem too eager.\" \" ", "You're an idiot.\" \" ", "I really am.\" \"", "Heh.\" \"", "Come here.\" \"", "I'll see you later, little brother.\" \"", "Bye.\" \"", "Come here.\" \"", "Are we doing this ironically or...?\" \" ", "We can tell ourselves that.\" \" ", "Okay, good.\" \"", "Okay, keep in touch.\"" ]

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[ "Gerard Mannix Flynn i Maedhbh McMahon\n\nKościół pośrednio przejął kontrolę nad władzami konstytucyjnymi Irlandii – i bezpośrednio nad edukacją, opieką społeczną, nad rodziną, nad sypialnią, nad dziećmi, a państwo na to pozwoliło. ", "Sytuacja Irlandii powinna być dla was w Polsce ważnym punktem odniesienia – i ostrzeżeniem. ", "Z Gerardem Mannixem Flynnem i Maedhbh McMahon rozmawia Agata Diduszko-Zyglewska.", "\n\nWesprzyj nas Wspiera nas 1 na 433 czytających. ", "Pomóż nam to zmienić Przekaż darowiznę\n\nGerard Mannix Flynn i Maedhbh McMahon w swoim filmie opowiadają o tym, co się dzieje w kraju, w którym Kościół katolicki w porozumieniu z władzami systemowo przejmuje kontrolę nad edukacją, opieką społeczną i zdrowiem, a także najbardziej intymnymi sferami życia ludzi – i ostrzega Polaków: Kościół dąży do osiągnięcia tego układu z państwem w Polsce, a jeśli mu się to uda, zapłacą za to dzieci, kobiety i biedni.", "\n\nGerard Mannix Flynn, irlandzki pisarz, performer i radny Dublina, był jednym ze stu tysięcy dzieci, które zabrano rodzicom i umieszczono w tzw. ", "szkole przemysłowej. ", "Te kościelne instytucje prowadzone przez zakon Braci w Chrystusie były właściwie połączeniem więzień i obozów pracy, w których przetrzymywano dzieci z klasy ludowej. ", "Kościół dostawał od państwa pieniądze na każde dziecko za instytucjonalną opiekę nad nim, a do tego zarabiał na produktach niewolniczej pracy dzieci.", "\n\nFlynn został zgwałcony przez zakonnika po raz pierwszy w samochodzie wiozącym go do „szkoły”. ", "Miał wtedy siedem lat. ", "Przez kolejne lata gwałty i maltretowanie były jego – i innych dzieci – codziennością. ", "Po dwóch latach wydostał się z tej „szkoły”, ponieważ po kolejnym pobiciu doznał obrażeń jamy brzusznej, które groziły śmiercią. ", "Wkrótce trafił „pod opiekę” kolejnej kościelnej instytucji. ", "Tę samą drogę przeszli jego rodzice, wszyscy jego bracia i siostry, a w kolejnym pokoleniu – bratanice i siostrzeńcy.", "\n\nMaedhbh McMahon jest z kolei scenografką i badaczką, która przez wiele lat zajmowała się sprawą pralni sióstr magdalenek, w których zakonnice wykorzystywały niewolniczą pracę kobiet, zamykanych tam dożywotnio za urodzenie nieślubnego dziecka. ", "Wspólnie z Gerardem Flynnem nakręcili film Kraj bez Boga i zajmują się ujawnianiem zbrodni popełnianych przez Kościół w Irlandii na kobietach i dzieciach, za które do dziś żaden duchowny nie poniósł odpowiedzialności karnej.", "\n\nAgata Diduszko-Zyglewska: Tak zwane szkoły przemysłowe (industrial schools) działały od połowy XIX wieku do 2007 roku! ", "Dzieci z klasy ludowej, pokolenie za pokoleniem, padały tam ofiarami gwałtów, maltretowania oraz były wykorzystywane do niewolniczej pracy. ", "Byłeś jednym z nich. ", "Jak to możliwe, że przez całe dekady społeczeństwo nie reagowało na te systemowe przestępstwa?", "\n\nGerard Mannix Flynn: Do niedawna nikt w Irlandii nie rozmawiał publicznie o seksualności. ", "Podobnie jak w innych krajach katolickich seksualność łączono z poczuciem wstydu i spychano do sfery tabu, a kobiety i dzieci traktowano jak obywateli gorszej kategorii, którym nie należą się te same prawa co mężczyznom. ", "Do tego dopiero niedawno zakazano w Irlandii stosowania kar cielesnych w szkołach i w domu. ", "Kiedy byłem dzieckiem, bicie dzieci w szkole było normą. ", "Dotkliwe pobicie przez rodziców też było normą. ", "Prawo nie chroniło dzieci i panowało przekonanie, że to nie szkodzi. ", "Że dzieci łatwo zapominają o biciu i nie wpływa to na ich dalsze życie. ", "Teraz już wiemy, że jest przeciwnie – to trauma na całe życie.", "\n\nDlaczego tak długo nie zauważano problemu?", "\n\nGF: Związek państwa i Kościoła z jego „nauką” wytworzył mechanizm totalitarnego podejścia do kobiet, dzieci i biednych, czyli obywateli z klasy ludowej. ", "Kościół zdominował każdy aspekt naszego życia osobistego i społecznego. ", "Każde przekroczenie norm wyznaczonych przez Kościół mogło oznaczać wykluczenie ze społeczności przez wyrok wydany z ambony. ", "Taki wyrok oznaczał ostracyzm polityczny, problemy w pracy i w szkole. ", "Ponieważ seks był tematem tabu, a podporządkowanie kobiet mężczyznom normą zapisaną w religii, to także zgłaszanie tego rodzaju przestępstw – gwałtu, molestowania – było przekroczeniem normy i prawie nie istniało. ", "I ten kontekst sprawił, że tak łatwo było państwu i Kościołowi pominąć milczeniem przemoc i terror w szkołach przemysłowych, które w istocie były więzieniami dla dzieci z klasy ludowej.", "\n\nCzy ten problem dotykał tylko ludzi z klasy ludowej?", "\n\nGF: Oni, a zwłaszcza kobiety i dzieci, byli głównymi ofiarami. ", "Klasa średnia lepiej radziła sobie z katolicką opresją, ale kobiety z klasy średniej, które zaszły w ciążę bez ślubu, także często lądowały w tragicznej sytuacji. ", "Te kobiety były wykluczane ze społeczeństwa. ", "Te biedniejsze, z klasy ludowej, zdesperowane i postawione w sytuacji bez wyjścia, nierzadko dokonywały dzieciobójstw. ", "Wtedy trafiały do więzienia lub na resztę życia do pralni sióstr magdalenek, w których pracowały jako niewolnice – bez pensji i bez prawa wyjścia. ", "Do pralni trafiały też te, które nikogo nie zabiły. ", "Zabierano im dzieci, które sprzedawano do adopcji, np. ", "w Stanach Zjednoczonych.", "\n\nAgata Diduszko-Zyglewska Krucjata polska 39,90\n\nDo tego kościelne ośrodki budowano w taki sposób, że przetrzymywane tam rodziny nie mogły mieć ze sobą kontaktu. ", "Kobiety z pralni nie miały żadnego dostępu do przytułku, w którym trzymano ich dzieci. ", "Rodziny, które przychodziły do kościoła, nie miały szansy zobaczyć członków rodzin, których przetrzymywano w tych przybytkach. ", "Niektórzy rodzice mogli odwiedzać swoje dzieci, ale nawet kiedy widzieli, że są sine z powodu maltretowania, nie mogli nic powiedzieć. ", "Sami przeszli wcześniej to samo, a osiągnąć mogli tyle, że odmówiono by im wizyt.", "\n\nDlatego tak wielu ludzi uciekało z Irlandii. ", "Uciekali do Anglii i do Stanów Zjednoczonych. ", "Uciekali przed biedą, ale także przed opresją ze strony katolickich instytucji. ", "Uciekały kobiety, którym umarli mężowie, bo przez długi czas wdowom odbierano dzieci. ", "Po prostu Kościół nie uznawał niepełnej rodziny i miał powód, żeby zyskać nowych klientów instytucji, czyli darmową siłę roboczą i pieniądze od państwa, które za nimi szły.", "\n\nMaedhbh McMahon: To był system, który pozwalał wykorzystywać każdego człowieka przez wiele lat. ", "Państwo dawało pieniądze na każde dziecko urodzone w Domu Matki i Dziecka, na każde dziecko przeniesione potem do sierocińca, na każdą matkę pozbawioną dziecka i przeniesioną do pralni, na każdą dziewczynkę, która trafiała z sierocińca do pralni (jako dwunastolatka) lub do szkoły przemysłowej i na każdego chłopca, który trafiał do takiej samej szkoły dla chłopców. ", "W papierach powód odbierania matkom dzieci kwitowano krótkim sformułowaniem: moralny upadek.", "\n\nPrzetrzymywanie tych ludzi było źródłem sporych dochodów dla Kościoła. ", "Do tego dochodziły dochody wypracowane na rzecz zakonu przez te dzieci i kobiety jako niewolników. ", "Pralnie przynosiły przecież zakonowi i Watykanowi spore zyski. ", "I ten system przepływu finansów działa do tej pory, dlatego Kościół skrupulatnie pilnuje, żeby nic się nie zmieniło, żeby ci ludzie pozostali klientami opieki społecznej, żeby szkoły były katolickie. ", "To źródło stałego gigantycznego zarobku. ", "Podczas kilku lat pracy przeprowadziliśmy mnóstwo rozmów, które ilustrowały działanie tego systemu.", "\n\nOpowiesz konkretną historię?", "\n\nMM: Jednym z naszych rozmówców był człowiek romskiego pochodzenia, którego odebrano matce, kiedy był półtorarocznym dzieckiem. ", "Odebrano jej także kilkoro starszych dzieci za to, ze miała romans poza małżeństwem. ", "Polityka była taka, że każde z tych dzieci trafiło w inne miejsce, po to, żeby nie pamiętali, że mieli rodzeństwo. ", "Dzieci zabrano na zawsze. ", "Nie było możliwości odwołania. ", "Wszystkie były trzymane w kościelnych instytucjach do szesnastego roku życia.", "\n\nPo szesnastych urodzinach wyrzucano ich na bruk, bo kończyło się państwowe dofinansowanie dziecka „wziętego pod opiekę”. ", "Temu chłopcu powiedziano, że nie ma żadnej rodziny, że nikt go nie chciał. ", "Nie wiedział, jak przetrwać, kradł jakieś jedzenie w sklepach, próbował wracać do tej instytucji i prosić o jedzenie, bo umierał z głodu.", "\n\nW końcu trafił do więzienia. ", "Rodzinę odnalazł po latach poszukiwań. ", "Poznał historię swojego ojca. ", "Okazało się, że matka zdradziła ojca z księdzem. ", "Kiedy ojciec dowiedział się o tym, poszedł do tego księdza i uderzył go w twarz – i to w związku z tym jego zamknięto w szpitalu psychiatrycznym na resztę życia, a matce odebrano wszystkie dzieci. ", "Szpitale psychiatryczne były wypełnione ludźmi, którzy wystąpili przeciwko państwowo-kościelnemu systemowi.", "\n\nGF: Część dzieci nie miała szans dotrwać do szesnastego roku życia. ", "Jakiś czas temu niedaleko Galway odkryto masowy grób dzieci – od niemowląt do trzylatków – zawierający około ośmiuset ciał. ", "Z autopsji wynika, że przyczyny śmierci dzieci obejmowały zagłodzenie, wyziębienie i inne sprawy związane z brakiem opieki. ", "To grób związany z działalnością katolickiego Domu Matki i Dziecka.", "\n\nKobiety i nastolatki w ciąży, które nie były mężatkami, były zmuszane do rodzenia w tego rodzaju instytucjach rozsianych po kraju. ", "Dzieci zaraz po porodzie odbierano matkom, a kobiety odsyłano do rodziców lub zamykano w pralniach magdalenek. ", "Opinia publiczna dowiedziała się o tym grobie około czterech lat temu, ale lokalna społeczność wiedziała o jego istnieniu wcześniej. ", "Dla zakonnic te dzieci, jako owoc grzechu, nie były ludźmi. ", "Spośród tych, których nie dało się sprzedać do adopcji, części pozbyto się w bardziej drastyczny sposób.", "\n\nJednocześnie obowiązywał całkowity zakaz aborcji w imię „ochrony życia”.", "\n\nGF: Jak widać, nie z powodu szacunku dla ludzkiego życia. ", "Chodziło oczywiście o totalną kontrolę nad kobiecym ciałem i nad życiem seksualnym. ", "Takie połączenie sfery seksu z niebezpieczeństwem odbierało ludziom możliwość korzystania z intymności. ", "Intymność zatruta strachem przed niechcianą ciążą i dramatycznymi konsekwencjami relacji nieakceptowanej przez państwo wyznaniowe uniemożliwiała intymność. ", "Bo jedyna oficjalnie dopuszczalna intymna relacja to ta z Bogiem.", "\n\nW tezę o Kościele katolickim dbającym o życie ludzkie i stawiającym je w centrum wierzyć może tylko ktoś, kto nie ma pojęcia o historii – katolicy w imię krzewienia swojej wiary w świętość ludzkiego życia zamordowali miliony ludzi na kilku kontynentach. ", "Historia Kościoła – od kiedy chrześcijaństwo stało się religią państwową w Rzymie – to historia przemocy fizycznej i seksualnej, wykorzystywania ludzi jako niewolników i okrutnego zabijania w imię nawracania.", "\n\nTrzy pokolenia twojej rodziny padły ofiarą katolickiego systemu państwowego. ", "Twoi rodzice byli katowani i gwałceni w tych samych szkołach, do których potem zabrano ciebie. ", "Opowiadasz tę historię w filmie dokumentalnym Kraj bez Boga. ", "A głównym oskarżonym, poza państwem, jest według ciebie klasa średnia.", "\n\nGF: Udało mi się daleko uciec od tamtych miejsc. ", "Jestem pisarzem, reżyserem, radnym Dublina. ", "Współtworzyłem kampanie, które miały na celu ujawnienie przestępstw Kościoła w Irlandii. ", "Walczę o sprawiedliwość dla ofiar od pięćdziesięciu lat. ", "I przez długi czas trudno było przekonać ludzi do zrozumienia, że to problem klasowy; że dotyczy tego, jak państwo traktuje całą klasę obywateli. ", "Dalej jest to trudne, ponieważ ten fenomen polega na tym, że klasa średnia przez długi czas po prostu nie dostrzegała tego, co się dzieje.", "\n\nI niestety w dużej mierze tak jest do tej pory. ", "Kolejne pokolenia, dzieci tych dzieci, które przeszły piekło katolickich szkół przemysłowych, żyją w tej samej biedzie i wciąż pod kontrolą instytucji Kościoła katolickiego. ", "Klasa średnia w pewien sposób wykorzystuje dalej tych ludzi, ekscytując się tymi historiami rodem z horroru i nie zmieniając zasadniczego położenia klasy ludowej.", "\n\nNie udało się przebić z tym problemem do polityków i dziennikarzy?", "\n\nGF: Po części problem polega na tym, że w Irlandii nawet lewicowi politycy i dziennikarze z klasy średniej są związani z Kościołem, a zatem nie ma nikogo, kto spojrzałby na to z boku i powiedział głośno: ci ludzie muszą zostać uwolnieni spod jarzma tej instytucji. ", "Dlatego to uwolnienie nie nadchodzi, pomimo ujawnienia tak wielu przestępstw popełnionych przez Kościół. ", "Systemowa religijno-polityczna przemoc trwa nadal. ", "Z niepokojem patrzę na to, że międzynarodowe organizacje, które zajmują się sprawami w Rwandzie i na Bliskim Wschodzie, kompletnie przestały interesować się sytuacją w Irlandii. ", "A przecież do tej pory nikt z kierownictwa tych szkół i instytucji nie poszedł do więzienia.", "\n\nJak to możliwe? ", "Przecież nazwiska duchownych dyrektorów szkół, w których dochodziło do przemocy, są znane.", "\n\nGF: Żadna sprawa nie trafiła do sądu. ", "Sprawy wyciszano na poziomie prokuratury. ", "System edukacji w Irlandii jest całkowicie opanowany przez Kościół. ", "To oznacza, że ścieżki kariery także zależą od dobrych relacji z Kościołem. ", "Rodzice z klasy średniej, także prawnicy, dziennikarze, aktywiści, którzy chcą, żeby ich dzieci dostały się do dobrych szkół, nie mogą atakować Kościoła.", "\n\nKlasa średnia w pewien sposób wykorzystuje dalej tych ludzi, ekscytując się tymi historiami rodem z horroru i nie zmieniając zasadniczego położenia klasy ludowej.", "\n\nZresztą uważają nasze relacje za straszliwe jednostkowe tragedie, które nie wydarzą się w tych renomowanych szkołach, do których trafią ich dzieci. ", "Oczywiście żal im tych skrzywdzonych dzieci, kiedy kolejne sprawy wychodzą na wierzch, ale wciąż przymykają oko na fakt, że to krzywda systemowa wobec dziesiątek tysięcy dzieci z kilku pokoleń, których jedyną przewiną było to, że urodziły się w biednej rodzinie. ", "Kościół także próbuje zwyczajnie przemilczeć sprawę. ", "Kiedy kolejny koszmar trafia do mediów, zapewniają o swoim żalu i zmawiają modlitwy za ofiary. ", "Niespecjalnie przejmują się tym, że żadna modlitwa nie powstrzymała jeszcze żadnego sprawcy przed zgwałceniem dziecka.", "\n\nWy w Polsce także macie podobne doświadczenia – modlitwy Polaków nie powstrzymały żadnej niemieckiej bomby przed zniszczeniem waszego kraju i nie powstrzymują sprawców w waszym Kościele przed krzywdzeniem dzieci. ", "Tego może dokonać tylko państwo poprzez prokuraturę, sądy i policję. ", "Państwo splecione z Kościołem porzuca swoich obywateli.", "\n\nSzkoły, w których padłeś ofiarą gwałtów i maltretowania, prowadzili Bracia w Chrystusie. ", "Oskarżenia o molestowanie dzieci przez członków tej kongregacji od kilku lat docierają także z Kanady, Australii i Wielkiej Brytanii. ", "Czy ta organizacja dalej działa w Irlandii?", "\n\nGF: Tak, działa i jest bardzo potężna. ", "Tych przestępstw dopuszczali się w szkołach przemysłowych, natomiast szkoły dla dzieci z wyższych klas prowadzili wzorowo, dlatego mają wielu obrońców, wielu mocno związanych z Kościołem katolików, którzy nie wierzą, że mogliby zrobić coś takiego. ", "Pomimo tego, że w 2007 zamknięto szkoły przemysłowe, bo na światło dzienne wyszły informacje, że biskupi wiedzieli o przemocy i gwałtach i nie reagowali. ", "Nawet nie sam los dzieci był kluczowy, tylko właśnie fakt, że biskupi, czyli de facto Kościół, był wszystkiego świadomy.", "\n\nBiskupi do końca twierdzili, że nic nie wiedzieli, ale udowodniono im bez żadnych wątpliwości, że wiedzieli i aktywnie tuszowali te zbrodnie. ", "Irlandzkie społeczeństwo wypłaciło już ofiarom około dwóch milionów euro zadośćuczynienia. ", "Ale biskupi i zakonnicy nie ponieśli odpowiedzialności, bo Kościół, który działa jak naprawdę potężna korporacja, zabezpieczył ich przed tym.", "\n\nJak udało się doprowadzić do wypłaty zadośćuczynień?", "\n\nGF: Udało się dzięki wielu różnym czynnikom, ale jeden był kluczowy, i to ważna informacja także dla ofiar w Polsce. ", "Udało się tym, którzy nie zwracali się o pomoc do biskupów, tylko szli bezpośrednio na policję, czyli oficjalnie uruchamiali mechanizmy państwowe. ", "Jak wiecie, Kościoły w efekcie ujawnienia zbrodni w Irlandii w ostatnich latach opustoszały, ale nie są puste. ", "Miejsce Irlandczyków zajęli polscy imigranci. ", "Dlatego jeżeli chcecie, żeby Kościół poniósł konsekwencje swoich czynów, to może powinniście pojechać pod te kościoły z banerami po polsku i zapytać waszych katolików, czy groby zamordowanych przez kościelne instytucje niemowląt nie robią na nich wrażenia i nie wywołują refleksji co do moralnej natury tych miejsc.", "\n\nSprawę badała słynna Komisja Ryana. ", "Jaki był efekt jej prac?", "\n\nGF: Komisja zbadała skalę przemocy i przemocy seksualnej wobec dzieci w instytucjach na przestrzeni kilku dekad. ", "Wydała pięciotomowy szczegółowy raport, w którym jednak nie wymieniono z nazwiska żadnego sprawcy, dlatego po jego publikacji żadna sprawa nie trafiła do prokuratury. ", "Komisja poznała nazwiska sprawców. ", "Jednak zeznania złożone przez ofiary zostały sklasyfikowane jako tajne i objęte tajemnicą na kolejne 75 lat.", "\n\nJak to możliwe?", "\n\nGF: Taka była umowa między państwem a Kościołem. ", "Niektórzy podnoszą wątpliwości co do legalności tej umowy. ", "Moim zdaniem europejska komisja antymonopolowa powinna przyjrzeć się tej sprawie, bo może być tak, że ta umowa jest zwyczajnie niezgodna z europejskim prawem. ", "Niestety międzynarodowe orzeczenia, które już mamy – dotyczące np. ", "niewolnictwa w pralniach przemysłowych – nie wywołują skutków prawnych w Irlandii.", "\n\nA protesty uliczne? ", "Było o nich głośno np. ", "podczas wizyty papieża Franciszka.", "\n\nGF: Protesty także są ignorowane. ", "Zresztą w protestach głównie brali udział ludzie z klasy średniej, którzy zwyczajnie nie do końca znają te historie, więc nie umieją sformułować właściwych postulatów. ", "Znów wracamy tu do problemu klasowego. ", "Społeczeństwo wciąż nie chce udzielić głosu samym ofiarom, czyli ludziom z klasy ludowej.", "\n\nTak samo było w sprawie pralni przemysłowych i Domów Matki i Dziecka. ", "Media nie zapraszały ofiar, żeby opowiedziały swoje historie – zapraszały historyka-amatora, który zajął się badaniem tych spraw, i to on opowiadał, co uważał. ", "A przecież ofiary żyją i mogą mówić same za siebie! ", "Mój film, Kraj bez Boga, jest jednym z pierwszych świadectw samych ofiar w irlandzkiej debacie publicznej.", "\n\nCzy po ujawnieniu przestępstw zmieniła się pozycja Kościoła w Irlandii?", "\n\nGF: Zmieniło się podejście ludzi do Kościoła. ", "Przestali chodzić na msze i ufać Kościołowi. ", "Tak jak zmieniła się moda i przestali nosić pewne ubrania, a zaczęli inne. ", "Ale to nie oznacza, że zmieniła się pozycja Kościoła i jego możliwości wpływania na rzeczywistość społeczną.", "\n\nO dwunastej słyszymy kościelne dzwony w publicznych mediach. ", "Kościół kontroluje szkolnictwo i opiekę społeczną. ", "Ma gigantyczne połacie ziemi. ", "Ma ogromny wpływ na prawodawstwo również dlatego, że ogromna część elity politycznej to katolicy, wychowankowie katolickich szkół. ", "Nawet posiedzenie Rady Miasta Dublina zaczyna się od modlitwy! ", "Ujawnienie skali przestępstw w kościelnych instytucjach nie wywołało skutku, którego się spodziewano. ", "W ogromnej mierze Kościół pozostał nietykalny, a sprawcy całkowicie bezkarni.", "\n\nA jednak udało się zmusić państwo do odejścia od fundamentalizmu katolickiego w kilku sprawach.", "\n\nGF: Tak, dzięki aktywizacji części społeczeństwa i organizacjom pozarządowym udało się po referendum doprowadzić do liberalizacji prawa antyaborcyjnego, ułatwienia rozwodów i legalizacji małżeństw jednopłciowych, a jednak wciąż nie udaje się doprowadzić przed sąd odpowiedzialnych za gwałcenie i torturowanie dziesiątek tysięcy dzieci z klasy ludowej w kościelnych instytucjach.", "\n\nInnymi słowy, udało się wymusić pewne wyjście naprzeciw obywatelom w kwestiach dotyczących prawa cywilnego, natomiast prawo karne wciąż nie dotyczy funkcjonariuszy Kościoła. ", "Chciałbym przestrzec ludzi w Polsce przed taktyką szukania pomocy u biskupów czy papieża zamiast w państwie. ", "Działając w ten sposób, respektujemy fakt, że ci ludzie są ponad prawem, i sami nadajemy im ważność i immunitet. ", "A do tego mieszamy rolę sprawcy i sędziego, co nigdy nie prowadzi do należytego wyjaśnienia spraw. ", "Nikt nie może być sędzią we własnej sprawie – także Kościół.", "\n\nCzy któraś z partii politycznych w Irlandii wspiera projekt zmiany relacji między państwem a Kościołem?", "\n\nGF: Są konkretni politycy zainteresowani zmianą tych relacji, ale w wielu kwestiach się wahają, są niepewni, niestabilni. ", "Grupą, od której może wyjść sensowny i mocny impuls w tej sprawie, są osoby, które odeszły z Kościoła: byli księża, zakonnicy, wierni. ", "Jest ich sporo, ale problem w tym, że oni do tej pory się nie zorganizowali, nie ustalili wspólnej agendy działania, a niektórzy w ogóle nie podjęli decyzji, czy są w stanie działać w kontrze do Kościoła takiego, jakim jest obecnie.", "\n\nLewica niestety jest niepozbierana, są przeciwni kościelnej dominacji w państwie, ale nie potrafią tego przekonująco uargumentować, nawet teraz, kiedy wiemy już to wszystko. ", "Nie rozumieją, dlaczego elementem, którego w tym procesie nie da się pominąć, jest upodmiotowienie ludzi z klasy ludowej.", "\n\nJak to zrobić?", "\n\nGF: Konieczne jest stworzenie ogólnokrajowego systemu opieki psychoterapeutycznej nad tymi ludźmi, bo jednym ze skutków przeżywania tortur i gwałtów w dzieciństwie jest wypadnięcie ze struktur społecznych. ", "Ci ludzie jako dorośli nie mają edukacji, która dawałaby im narzędzia do właściwego, pełnego opowiedzenia historii swojej opresji, mają za to kłopoty z narkotykami, alkoholem, replikowaniem przemocowych schematów.", "\n\nMieszamy rolę sprawcy i sędziego, co nigdy nie prowadzi do należytego wyjaśnienia spraw. ", "Nikt nie może być sędzią we własnej sprawie – także Kościół.", "\n\nTo wszystko nie pozwala im się wydobyć z koszmaru. ", "Niektórzy umierają, inni pozostają ofiarami na całe życie. ", "Państwo musi się skupić na ofiarach i pomóc im wydobyć się z piekła, w które ich wtrąciło jako bezbronne dzieci. ", "I musi doprowadzić przed oblicze sprawiedliwości sprawców. ", "Ci księża, zakonnicy i zakonnice jako dyrektorzy i wychowawcy działali jak ekstremiści, dopuszczając się długotrwałej, systemowej, okrutnej przemocy wobec dzieci, pozbawiając wszelkich praw ich rodziców.", "\n\nMożna to porównać do aktów terroryzmu – do tego popełnianych przez ludzi dzierżących lukratywne stanowiska. ", "A tymczasem po ujawnieniu tych spraw zaproponowano nam, żebyśmy im po prostu przebaczyli! ", "Czy ktokolwiek może czuć się bezpiecznie w państwie, które działa w taki sposób?", "\n\nZresztą ich nie interesuje żadne przebaczenie. ", "Przekierowanie tego problemu z poziomu odpowiedzialności karnej na poziom chrześcijańskiego miłosierdzia dla sprawców służy zwyczajnie ochronie pracowników, pozycji i dobrostanu Kościoła przed jakimkolwiek naruszeniem. ", "A z tego wynika tyle, że podobne przestępstwa będą zdarzać się dalej. ", "Zresztą w Irlandii toczy się kolejna sprawa – tuszowania seksualnego molestowania katolickich skautów podczas obozów.", "\n\nPodobne sprawy wychodzą na jaw w Niemczech, w Austrii, na Filipinach i wielu innych krajach – i będą się pojawiały dalej, dopóki nie nastąpi systemowa zmiana podejścia do Kościoła i jego instytucji. ", "Te sprawy powinny być traktowane jako przejawy przestępstwa zorganizowanego, rozpatrywane zgodnie z procedurami stworzonymi dla grup przestępczych – po prostu dlatego, że mamy do czynienia z działaniem systemowym, zinstytucjonalizowanym.", "\n\nTa instytucjonalizacja czyni z tego sytuację bez wyjścia. ", "Bo organizacje charytatywne, które mają pomagać biednym, to w Irlandii organizacje katolickie, nawet lewica to katolicka lewica, dlatego to, co ma być uwolnieniem, szansą na wyjście z opresji, w istocie bywa indoktrynacją pod płaszczykiem celów charytatywnych. ", "Ta indoktrynacja ma na celu ochronę Kościoła. ", "I utrzymanie status quo, czyli ubezwłasnowolnienia ludzi z klasy ludowej.", "\n\nCzy twoi krewni, którzy opowiedzieli ci przed kamerą, co im się przydarzyło, nie bali się o tym mówić?", "\n\nBardzo trudno było mi namówić moją rodzinę – moich braci, siostry, siostrzeńców i bratanice – do mówienia. ", "Oni sami nawet nie znali całości tej historii, każde znało swój kawałek. ", "Dzięki mojemu filmowi także dla nich stała się spójną całością, opowiedzianą własnym głosem, a nie zapośredniczoną przez zewnętrzną, ubarwiającą narrację. ", "Nie chciałem robić drugiego Spotlight. ", "Chciałem pokazać naszą prawdę, nasze uczucia wobec tego, co nam zrobiono.", "\n\n„Kraj bez Boga”, jako określenie Irlandii zaproponowane w tytule filmu, to antyteza tego, jak twój kraj prezentował się światu do tej pory.", "\n\nIrlandia rzeczywiście reklamowała się jako najbardziej katolicki kraj Europy, kraj wiary, kolebka księży, mnichów, misjonarzy, których można spotkać na całym świecie. ", "Sęk w tym, że ci wszyscy ludzie właśnie używając tego szyldu, popełnili mnóstwo przestępstw i nadużyć – nie tylko w samej Irlandii – które od kilkunastu lat jedno za drugim wychodzą na jaw. ", "Tortury, nadużycia seksualne, wykorzystywanie niewolniczej pracy – irlandzki Kościół ma gigantyczny bagaż na plecach.", "\n\nMój film pokazuje, że my, ludzie z klasy ludowej, nie daliśmy się nabrać na to, że mamy „przebaczyć i zapomnieć”. ", "I to jest nasz przekaz do ludzi w Polsce i innych krajach: przebaczanie i zapominanie oznacza tyle, że przestępcy nie odpowiedzą za swoje czyny. ", "Nie ma powodu, żeby tak się stało.", "\n\nMaedhbh, czy w przypadku pralni magdalenek sprawa także nie skończyła się zadośćuczynieniem, które by ją zamykało?", "\n\nMM: Te pralnie zamknięto dopiero w drugiej połowie lat 90. ", "Wybuchł skandal związany z odkryciem nieoznaczonych masowych grobów kobiet zamkniętych w tych pralniach, po tym, jak zakon sprzedał kawałek ziemi deweloperowi. ", "Zakonnice próbowały zatuszować sprawę, poddając szybkiej kremacji większość ciał, ale zaczęły mówić kobiety-ofiary. ", "Okazało się, że kobiety, które tam trafiały – matki nieślubnych dzieci, ofiary gwałtów, dziewczyny oskarżane o „złe prowadzenie się”, kobiety upośledzone czy mające kłopoty z prawem – często dostawały właściwie dożywocie, były bite, molestowane, poniżane i traktowane jak niewolnice.", "\n\nRodziny, w których brakowało pieniędzy, wysyłały tam dziewczynki bez powodu, żeby odciążyć domowy budżet. ", "I one nigdy już stamtąd nie wychodziły. ", "Kobiety trafiały tam z polecenia księży, ale też rządu! ", "Niektóre najpierw trafiały do Domu Matki i Dziecka, w których rodziły, a potem odbierano im dzieci. ", "Jeśli nikt ich nie wykupił, matki trafiały do pralni, a dzieci sprzedawano do zagranicznej adopcji lub umierały na miejscu. ", "Do pralni trafiały też dzieciobójczynie, a było ich sporo, bo brak edukacji seksualnej i dostępu do antykoncepcji i aborcji sprawiał, że kobiety w strachu przed wstydem i wykluczeniem zabijały noworodki. ", "Oficjalne przeprosiny ofiarom złożył premier Enda Kenny dopiero w 2013 roku.", "\n\nW przeciwieństwie do Mannixa jesteś z klasy średniej, którą on oskarża o bierność i przymykanie oczu na los obywateli z klasy ludowej. ", "Jak ty to widzisz?", "\n\nMM: Wychowując się w klasie średniej, do momentu poznania Mannixa nie słyszałam o szkołach przemysłowych. ", "W mojej okolicy nie było żadnej takiej szkoły i nikt z moich znajomych do niej nie trafił. ", "Słyszeliśmy o pralniach magdalenek, bo największy wstyd, jaki mógł się zdarzyć dziewczynie w latach 80., ", "to było nieślubne dziecko. ", "Straszono nas tym, że jest miejsce dla „takich” dziewczyn, ale nigdy go nie widzieliśmy.", "\n\nTe pralnie wykonywały zlecenia dla hoteli, szpitali, arystokracji, więc były rozsiane po całym kraju. ", "Mijałam kiedyś nieświadomie jedną tych pralni, która działała w Limerick. ", "Sądziłam, że to szpital psychiatryczny, bo widziałam tam kobiety ogolone do gołej skóry za zamkniętą bramą.", "\n\nCo się stało z tymi miejscami po zamknięciu pralni w latach 90.?", "\n\nMM: Te kobiety wciąż tam żyją. ", "Na początku XXI wieku wszystkie kobiety, które miały na zewnątrz jakąś rodzinę, mogły do niej wrócić, ale w większości wypadków wieloletnie odcięcie od świata sprawiło, że one nie miały już nikogo na zewnątrz. ", "W siedzibie jednej z tych pralni otwarto kilka lat temu wydział uczelni artystycznej. ", "Państwo zachęca uczelnie do przejmowania tych przestrzeni. ", "Muszę powiedzieć, że mam z tym pewien problem. ", "To trochę przypomina zacieranie śladów. ", "Nie ma tam żadnego upamiętnienia tego, co się w tych murach wydarzyło. ", "Nie jest to też przedmiotem twórczej pracy studentów.", "\n\nCzy studenci wiedzą, gdzie studiują?", "\n\nTak, zresztą te kobiety-ofiary mieszkają w domkach w sąsiedztwie. ", "Niestety oprócz wymuszonych protestami przeprosin wciąż nie dostały żadnego zadośćuczynienia od państwa. ", "W 2013 roku komisja, której przewodniczył ultrakatolicki senator Martin McAleese, opublikowała raport, z którego wynikało, że jedna czwarta kobiet trafiła do niewoli w pralniach z polecenia irlandzkiego rządu, natomiast nie udało się udowodnić winy za przemoc i zgony żadnej zakonnicy.", "\n\nNiestety widziałam już wiele irlandzkich raportów w tej sprawie, a jednocześnie rozmawiałam z bardzo wieloma ofiarami i nie mam wątpliwości, że państwo nie jest w stanie stworzyć bezstronnego raportu. ", "Kobiety składają zeznania, także badaczom na uniwersytecie – ale to jest katolicki uniwersytet, więc z tych zeznań nic nie wynika. ", "Państwo powinno otoczyć ofiary opieką psychologiczną i zapewnić im godne życie do śmierci, ale nie robi tego.", "\n\nWiele osób musiało współpracować z tymi pralniami. ", "Nie dopominają się o sprawiedliwość dla ofiar?", "\n\nMM: Pracując nad naszym filmem, przeprowadziliśmy wywiady z bardzo wieloma osobami: ofiarami, prawnikami, psychiatrami i innymi lekarzami, którzy kierowali kobiety do tych miejsc, ich współpracownikami. ", "Wszyscy unikali odpowiedzi na pytanie: co właściwie czują w związku z tym, jak to wyglądało i jak to wygląda do dziś.", "\n\nMarta Abramowicz Dzieci księży. ", "Nasza wspólna tajemnica 39,90\n\nJa nie mam problemu z mówieniem o tym, że wstydzę się jako Irlandka, że w moim kraju pozwalano na takie rzeczy, ale do pewnego momentu po prostu o tym nie wiedziałam. ", "Mam tylko jakieś rwane wspomnienia, np. ", "z imprez w pubach, na których bywałam podczas studiów w Londynie. ", "Ktoś wspominał tam o tego rodzaju miejscach, opowiadał, że przeżył straszne rzeczy. ", "Ale my w ogóle nie rozumieliśmy, o czym on mówi. ", "Pytaliśmy: dlaczego nie zmieniłeś szkoły? ", "Dlaczego nie poskarżyłeś się rodzicom?", "\n\nNie mieliśmy pojęcia, o jakiej rzeczywistości mówimy. ", "Zrozumiałam, o czym mówił wtedy ten chłopak, dopiero lata później, kiedy pracując z Mannixem, chodziłam i rozmawiałam z jego sąsiadami, znajomymi z dzielnicy. ", "Okazało się, że w tamtej okolicy wszyscy przeszli przez to piekło, o którego istnieniu my nie wiedzieliśmy. ", "Chodziłam z Mannixem na pogrzeb za pogrzebem ludzi w jego wieku i młodszych, którzy przeszli przez te instytucje, i myślałam: w moim sąsiedztwie to wszystko byłoby szokujące, ale jesteśmy porozdzielani i dzięki temu to było możliwe.", "\n\nCo zrobicie z tym materiałem, który macie, z tymi wszystkimi rozmowami?", "\n\nGF: Skończyliśmy pracę nad filmem, więc teraz spokojnie przejrzymy to wszystko i zobaczymy, co możemy z tym zrobić i co się zmieniło od czasu tych rozmów, bo niektóre z nich przeprowadziliśmy nawet 10 lat temu. ", "Najważniejsze jest to, żeby nie pozwolić przesunąć tych spraw w sferę wydarzeń historycznych, czyli takich, o których się mówi, ale w których nie ma już nic do zrobienia. ", "Bo jako społeczeństwo i państwo mamy jeszcze mnóstwo rzeczy do zrobienia, żeby oddać ofiarom sprawiedliwość i wydobyć je z tego koszmaru. ", "A żeby to osiągnąć, rozmowa musi dotyczyć nie tylko samych sprawców, ale też ich zwierzchników i kolejnych papieży, którzy otrzymywali oficjalne informacje o tym, co się dzieje w szkołach przemysłowych.", "\n\nMM: To dotyczy także waszego papieża Jana Pawła II. ", "Wiemy, że w przypadku niesławnej szkoły przemysłowej w Ardane, gdzie zsyłano pedofilów z innych miejsc, którzy wykorzystywali tam dzieci, także wasz papież dostawał listy od ofiar, na które, tak jak poprzedni papieże, nie odpowiadał. ", "Przebywało tam po kilkuset chłopców naraz i skala przemocy wobec nich i pomiędzy nimi była, jak później zbadano, ogromna. ", "Szkołę zamknięto w 1969 roku, ale od lat 50., ", "jeszcze długo po zamknięciu tej instytucji, ofiary słały swoje świadectwa do Watykanu, prosząc kolejnych papieży o ukaranie księży-sprawców okrutnych przestępstw na dzieciach. ", "Bez żadnego odzewu.", "\n\nGF: Kościół pośrednio przejął kontrolę nad władzami konstytucyjnymi tego kraju – i bezpośrednio nad edukacją, opieką społeczną, nad rodziną, nad sypialnią, nad dziećmi, a państwo na to pozwoliło. ", "I niestety, choć sytuacja uległa poprawie, ten monopol wciąż nie został przełamany. ", "A dopóki to nie nastąpi, Kościół nie poniesie odpowiedzialności za krzywdy irlandzkich kobiet i dzieci. ", "Sytuacja Irlandii powinna być dla was w Polsce ważnym punktem odniesienia – i ostrzeżeniem.", "\n\n*\n\nGerard Mannix Flynn i Maedhbh McMahon i ich film dokumentalny Kraj bez Boga byli gośćmi Festiwalu Millenium Docs Against Gravity w Warszawie. ", "Rozmowa z nimi jest kolejną z cyklu rozmów Agaty Diduszko-Zyglewskiej poświęconych negatywnej roli, jaką odgrywał Kościół katolicki w życiu społecznym, których więcej znajdziecie w jej książce Krucjata polska." ]

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[ "$\n\nStudent Badge\n\n$\n\nWatch: M.I.A. Shares Video For “Y.A.L.A.”\n\nM.I.A. messes with our heads\n\nWhere to begin? ", "Let’s start with the world’s biggest understatement found in the warning at the beginning of this video: “This film contains flashing images.” ", "In reality, M.I.A.’s new video for Y.A.L.A., from her new album, Matangi, is five minutes of neon glow-in-the-dark lighting madness. ", "It contains morphing images, colorful explosions, flashing lights, laser games and the singer’s never-ending badass-ness. ", "Daniel Sannwald directed the highly stimulating clip, and it was made in collaboration with the British magazine i-D and the fashion house Kenzo. ", "Watch it below." ]

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[ "\n\n**I Wonder About the Qur'an**\n\n_Published by_\n\nTHE ISLAMIC FOUNDATION, 2017\n\n_Distributed by_\n\nKUBE PUBLISHING LTD\n\nTel +44 (01530) 249230, Fax +44 (01530) 249656\n\nE-mail: info@kubepublishing.com\n\nWebsite: www.kubepublishing.com\n\nFirst published in Turkey by Uğurböceği Publications,\n\na Zafer Publication Group imprint, in 2008.", "\n\nText © 2008 Ozkan Oze\n\nTranslation © 2015 Selma Ayduz\n\nIllustrations © 2008 Zafer Publishing\n\nAll rights reserved. ", "No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without the prior permission of the copyright owner\n\n_Author_ Özkan Öze\n\n_Translator_ Selma Aydüz\n\n_Series Editor_ Dr Salim Aydüz\n\n_Illustrator_ Sevgi İçigen\n\n_Book design_ Zafer Publishing & Nasir Cadir\n\n_Cover Design_ Fatima Jamadar\n\nA Cataloguing-in-Publication Data record for this book is available from the British Library\n\nISBN 978-0-86037-513-5\n\neISBN 978-0-86037-553-1\n\nPrinted by Imak Ofset, Istanbul, Turkey\n\n**Contents**\n\nForeword\n\nWhy is the Qur'an in Arabic?", "\n\nWhy should I read the Qur'an in Arabic?", "\n\nShould I read the Qur'an in Arabic if I don't understand it?", "\n\nWhy did Allah use words in the Qur'an?", "\n\nWhy was the Qur'an revealed over such a long time?", "\n\nHow do we know that the Qur'an has not been changed?", "\n\nScience in the Qur'an\n\nWhy does it say: \"Will they not then consider the camels...?\" ", "in the Qur'an?", "\n\nWhy is the name of the longest surah in the Qur'an al-Baqarah (the cow)?", "\n\nThe Dictionary of the Qur'an\n\n**Foreword**\n\nTHE STORY OF the \"I Wonder About Islam\" series started one day with my son asking me, \"Why can't I see Allah, dad?\" ", "The question was so unexpected that I didn't know what to say, although I actually knew the answer.", "\n\nBut when he asked so suddenly, I just said, \"Umm, well...\" He opened his eyes wide and started staring at me as if to say _Come on, give me the answer!_ ", "I beat around the bush for a while. ", "You know, I was humming and hawing. ", "In the end, I said, \"Your eyes are so small, yet Allah is so big! ", "This is the answer to the question. ", "Because of this, you can't see Allah!\"", "\n\n\"Oh, really?\" ", "he said. ", "He turned his Spider-Man toy around in his hands. ", "Then, as if he hadn't said anything, he went to his room. ", "He was only five years old...\n\nPerhaps, for a child his age, this answer was enough. ", "I had handled the situation. ", "However, as he got older, he would ask heaps of new questions about Allah. ", "I had to prepare my answers.", "\n\nSo, that is how I started the \"I Wonder About Islam\" series.", "\n\nThe best thing about this book is that not only my kids, but kids from around the world can read my answers.", "\n\nThe first and second books in the \"I Wonder About Islam\" series consist of answers I have given to questions about Allah.", "\n\nIn the third book, you will find answers to questions about the Prophet, peace be upon him.", "\n\nThe fourth book is about the Muslim holy book, the Qur'an.", "\n\nHave I answered all the questions about all these topics? ", "Of course not! ", "I've only tried to answer the most frequently asked ones. ", "But if you look at how I have answered these questions, it will help you work out the answers to other questions yourself. ", "If you hang on to your question's tail and pull as hard as you can, a huge answer will follow.", "\n\nAnd after reading this book, you will see that questions don't frighten you as much as before. ", "You will bravely ask the questions you thought were the hardest to answer, and soon you will see that you can't think of a question that doesn't have an answer. ", "Asking a question is saying, \"I want to learn!\", \"", "I want to understand!\", \"", "I want to know better and love more!\" ", "You should never be afraid of asking questions, and don't ever give up asking questions! ", "Because a question is a key. ", "Every question opens a door for you. ", "And behind every door is a whole other world.", "\n\nFurthermore, asking a question is also a prayer. ", "Make sure you pray a lot so that your mind and heart are filled with the light of knowledge; so that your path is always bright.", "\n\nThe \"I Wonder About Islam\" series has been written using the works of the great Muslim scholar Said Nursi (1878–1960). ", "The answers given to the questions and the examples to help you understand the topics have all been taken from his _Risale-i Nur_ books.", "\n\nÖzkan Öze\n\n_İstanbul, 2012_\n\n_Alif Lam Mim Ra. ", " \nThese are the signs of the Book. ", " \nWhat your Lord has sent down \nto you [Prophet] is the truth, \nyet most people do not believe._", "\n\nSurah Al-Ra'd 13:1\n\n**Why is the Qur'an in Arabic?**", "\n\n_We have sent it down as an Arabic Qur'an so that you may understand._", "\n\nSurah Yusuf 12:2\n\nALIF, BA, TA are the first letters of the Arabic alphabet. ", "This was how my first Qur'an lesson started. ", "A long time ago.", "\n\nEvery summer's day, when all the children played games on the streets, I would put my Arabic book under my arm and go to the Arabic teacher's house, sad that I wasn't able to play outside.", "\n\nThe teacher would be waiting for me on the balcony as usual.", "\n\n\"Come child, come! ", "Open up your lesson!\"", "\n\nThe elderly woman would scan the lines of the Arabic book with me, her eyes barely visible under a pair of thick glasses.", "\n\nWhenever I made a mistake while reading she was always quick to correct me. ", "But it seemed that she never got angry or bored.", "\n\nIn fact, she always looked excited. ", "Even though she had read these words thousands of times before, she happily sat there, listening to me, helping me whenever I needed it.", "\n\nI didn't share her enthusiasm. ", "Instead of looking at the Arabic letters she pointed at, I would read the bit underneath that explained how to pronounce them.", "\n\nAnd the teacher would say: \"Well done child! ", "Well done child!\" ", "every time, and stroke my hair.", "\n\nAfter each lesson she told my mum how well I read, how fast I learned – unaware I was cheating all along.", "\n\nThis went on for a month.", "\n\nFrom time to time I would feel guilty. ", "I was lying to that lovely old woman. ", "However, I didn't stop.", "\n\nEventually, we finished that book – weeks before all the other children in the neighbourhood.", "\n\nThe teacher smiled wide and said: \"Well done child, well done child! ", "Now it is time to start reading the Qur'an!\"", "\n\nShe gave me a copy of the Qur'an to take home. ", "It didn't tell me, under every line, on every page, how to pronounce the Arabic.", "\n\nWhat would I do?", "\n\nThe next morning I left my Arabic book on the table, put my Qur'an under my arm and started walking to the teacher's house.", "\n\n_Oh no! ", "My stupid, big head!_ ", "I thought all the way.", "\n\nThe first surah of the Qur'an is _al-Fatihah_ and, thankfully, I knew it off by heart. ", "Without making it obvious to the teacher, I hummed my way through it, and finished my lesson for the day.", "\n\nThe next day we started Surah _al-Baqarah_.", "\n\n\"Read my child... don't be shy.\"", "\n\n\"Alif Lam Mim.\"", "\n\n_Ah! ", "This bit was easy..._\n\n\"Well done child, well done!\"", "\n\n\"Dhalika al...\"\n\n\"Read child, read, don't get nervous!\"", "\n\n\"Dhalika al-kitabuuuuuuu...\"\n\n\"You were reading so well the other day... _subhanallah_ what has happened?\"", "\n\nI struggled on for another week, the teacher reading far more than me.", "\n\nThen school started, so I could breathe a sigh of relief; the lessons had come to an end.", "\n\nMany years have passed since then. ", "And I've learned that I wasn't deceiving the teacher in those lessons, I was deceiving myself.", "\n\nWhen I was older, I had to get another Arabic book and learn to read the Qur'an by myself, at night, secretly. ", "Each time I got stuck, I thought about my old teacher; how excited she was whenever she opened the Qur'an, how it brought her so much joy.", "\n\nThis is the lesson she left me with: it is a book to enjoy and appreciate.", "\n\n**Why is the Qur'an in Arabic?**", "\n\nWhen I had to learn Arabic with the teacher, I would get home and think: _I wish the Qur'an was in English or Turkish! ", "I would read it so well that way._", "\n\nBut, if the letters of the Qur'an were in English, I probably wouldn't have read it anyway. ", "I was lazy and this thought was only an excuse to ease my guilt.", "\n\nBut it did make me think: _Why is the Qur'an in Arabic?_", "\n\nThe answer to this question isn't that hard to explain.", "\n\nThe Prophet Muhammad (peace be upon him) was an Arab and he lived in Arabia, amongst Arabs.", "\n\nSo, it shouldn't be a surprise that the Qur'an is in Arabic. ", "Otherwise, the Prophet and those around him wouldn't have understood it. ", "A Turkish, French or Chinese Qur'an wasn't going to be sent to an Arabic prophet, who lived amongst people that only understood Arabic.", "\n\nWould Allah, He who knows everything, who fills the heavens and the earth, do such an unwise thing?", "\n\nOf course not!", "\n\nIt does lead us to another question: _Why was the Prophet Muhammad chosen from amongst the Arabs? ", "Why wasn't the final prophet from another race?_", "\n\nNow, before answering this question, let's imagine we are Chinese Muslims. ", "In that case we would say: \"Why wasn't the Prophet chosen from amongst the Chinese? ", "Then the Qur'an would be in Chinese!\"", "\n\nIf we are English Muslims, what would we say? \"", "Why wasn't the Prophet chosen from amongst the English? ", "If that had been the case, the Qur'an would be in English!\"", "\n\nYou see, there's no end to this! ", "These types of questions could be asked for all races and languages on Earth.", "\n\nChanging the nationality of the prophet or the language of the Qur'an doesn't help. ", "The problem doesn't go away. ", "Some people would always be left upset.", "\n\nAllah had to do what was wisest. ", "He chose a continent from all the continents, a country from all the countries, a language from all the languages and picked a prophet, from all the people, to send the Qur'an to.", "\n\nJust like when He was creating the universe, He chose blue for the sky and green for the forests...\n\nJust like He chose to give wings to birds and trunks to elephants...\n\nJust like He chose to give hardness to rocks, freshness to water...\n\nJust as we don't think to say, \"Birds should have trunks\", we also have no need to say, \"Those elephants should fly\": because that is the way they have been created.", "\n\nJust as Allah chooses what should fly, what should swim and the animals that can run, He chooses His Messenger from whatever race He wants and sends His book in whatever language He wants.", "\n\nSo we shouldn't say, \"The Qur'an should have been in Turkish, or such and such a language...\", and we shouldn't say, \"The Prophet should have been Turkish or from such and such a race rather than Arabic...\"\n\nAllah creates everything with wisdom and in the most beautiful way. ", "And who knows what wisdom there is in it.", "\n\n**Why should I read the Qur'an in Arabic?**", "\n\nBEFORE WE START, let's remember that the Qur'an was first revealed in Arabic. ", "When you see it in English, or German, or Chinese, it is a translation. ", "A person has changed the words from Arabic into another language.", "\n\nAlthough a translation might have the same cover, and it might be called the Qur'an, there is a big difference. ", "Can you guess it?", "\n\nThe Arabic words were chosen by Allah – the creator of the universe. ", "The Qur'an is Allah's word.", "\n\nIn a translation, a person has had to choose the words. ", "However good they are, however nice they sound the words are different.", "\n\nOf course, the person that translated it has made sure it has the same meaning, but nevertheless, it is not the same as before.", "\n\nThink about your reflection in the mirror. ", "Is it the same as you? ", "Definitely not. ", "It looks just like you, but only on the surface. ", "It doesn't have your heart or soul.", "\n\nEven when it comes to the books that people write, translations are never as good as the original.", "\n\nThere are even some people who go and learn another language simply to read an author in their original language. ", "For example, many people learn English to be able to read the works of William Shakespeare, French to read Victor Hugo and German to read Goethe.", "\n\nSo it shouldn't surprise you to hear that people all over the world are learning to read Arabic right now.", "\n\nThey want to read Allah's words exactly as He revealed them.", "\n\nWhat a treat it is to read the Qur'an in its original language.", "\n\n**If a translation of the Qur'an isn't the same, should I read it?**", "\n\nOf course you should. ", "It will help you understand it.", "\n\nA translation of the Qur'an gives you a glimpse of the meaning. ", "And the meaning is very important.", "\n\nWherever you are living in the world, whatever language you are speaking, every Muslim should read the meaning.", "\n\nAllah says in the Qur'an:\n\n_This is a message to all people, so that they may be warned by it, and know that He is the only God, and so that those who have minds may take heed._", "\n\nSurah Ibrahim 14:52\n\nThe Qur'an is neither a book just for Arabs, nor has it been sent just for those who know how to read Arabic. ", "It's a book for all humankind. ", "Just like the Prophet is the prophet for all humankind.", "\n\nIn that case, all the people on Earth should read it and try to understand it.", "\n\nBut, to do so, everyone would have to learn Arabic, or the Qur'an would need to be translated into every language.", "\n\nIt's impossible for everyone to learn Arabic, so it's best to translate the Qur'an into all of the languages of the world.", "\n\nToday there are translations of the Qur'an in nearly every language that is being used on Earth. ", "Whether they are Muslim or not, everyone can read the Qur'an's meaning in a translation.", "\n\n**Is reading the meaning (the translation of the Qur'an) enough for us?**", "\n\nLet's use our imagination. ", "Picture this. ", "There is a spectacular palace full of countless treasures and priceless art in front of you.", "\n\nThe door of this palace is remarkable. ", "Its walls are covered in beautiful colours and patterns.", "\n\nBut, the beauty of the door and the outside is nothing compared to the beauty of the palace inside.", "\n\nYou want to go inside, don't you? ", "Just seeing the outside is nice, but the inside will take your breath away.", "\n\nNow, a translation of the Qur'an is like this. ", "It shows you what is on the outside; it gives you a glimpse of its beauty.", "\n\nHowever, to see the palace's treasures more closely, you have to get inside and spend time there.", "\n\nIt is the same with the Qur'an. ", "The really marvellous things are on the inside.", "\n\nJust reading the words, without trying to understand what they mean, is good, but it isn't enough for an inquisitive little child like you.", "\n\nNow, how about I offer you a guide to the palace? ", "One that tells you how to get inside and where to find the treasures!", "\n\nWell, there are thousands of guides to the Qur'an to choose from.", "\n\nOver the centuries, many great teachers have written books to help us, explaining the wonders inside the Qur'an.", "\n\nThese explanations are like guidebooks. ", "They take us around the Qur'an verse by verse, giving us help and guidance. ", "We call them _tafsirs_.", "\n\n_Tafsirs_ give us a much deeper understanding of the Qur'an.", "\n\nAn understanding that will show us the priceless antiques and the countless treasures that we might have missed before.", "\n\nLet me give you another example.", "\n\nReading the Qur'an but not understanding it is like only seeing the surface of the sea. ", "We look at it, gaze at its vast blueness and the shimmery movements under the sun, and think it is a beautiful. ", "But we know the sea is so much more.", "\n\nWith its millions of fish, pearls and corals, the sea is magical kingdom. ", "Far different and much more beautiful than it can be seen from the surface.", "\n\nLike the sea, the Qur'an is full of wonders. ", "Just imagine what treasures are inside the book of Allah.", "\n\n**Should I read the Qur'an in Arabic if I don't understand it?**", "\n\n_People, a teaching from your Lord has come to you, a healing for what is in [your] hearts, and guidance and mercy for the believers._", "\n\nSurah Yunus 10:57\n\nAS MUSLIMS, HOWEVER much we thank God it is not enough, because we have the joy to read and listen to the Qur'an in the language it was revealed in.", "\n\nAll of the other books that were sent to earlier prophets either do not exist or the words have been changed.", "\n\nBut not the Qur'an.", "\n\nIn a cave near Makkah, 1,400 years ago, the Angel Gabriel brought the Prophet the first verse:\n\n_Read! ", "In the Name of your Lord Who created._", "\n\nSurah al-'Alaq 96:1\n\nToday, all Muslims on Earth, whatever language they speak can, with a bit of effort, learn to read this verse in Arabic.", "\n\nThis is the case for the first verse revealed, and all the way to the last verse revealed.", "\n\nJust think how special that is. ", "We are using the same words that the Prophet taught his companions, that Angel Gabriel taught the Prophet, that Allah told to Angel Gabriel.", "\n\nThis is a great blessing that fills my heart with joy.", "\n\n**The language of the Quran: Islam's common language**\n\nWherever they're from, whatever language they speak, Muslims all recite the Qur'an in Arabic when they pray.", "\n\nIt doesn't matter whether the person is Chinese, Arabic, Turkish or English; they have to read the first verse in the Qur'an, _al-Fatihah_ , and a few other verses during the prayer.", "\n\nThis is the minimum Muslims should try to learn. ", "This isn't a very hard thing to do. ", "Memorising the surahs to perform _salah_ (prayer), and learning how to perform _salah_ , is just as easy as memorising the times tables.", "\n\nAllah revealed some short surahs in the last chapter of the Qur'an, such as Surah _al-Ikhlas_ (Purity), Surah _al-Kawthar_ (Abundance), Surah _al-Fil_ (The Elephant). ", "Not all surahs are long, like _al-Baqarah_. ", "These short surahs are usually read in less than a minute!", "\n\nTo this day, I've never seen anyone who performs _salah_ complain about reading the surahs in Arabic!", "\n\nOnce you know some surahs off by heart you should learn what the words mean, especially Surah _al-Fatiha_.", "\n\n**Reading the Qur'an is rewarding**\n\nReading the Qur'an is a rewarding act. ", "The Prophet said that for every letter of the Qur'an a person reads, a reward is written for the reader. ", "During the month of Ramadan, and in particular when it is _Laylat al-Qadr_ , the night of power, these rewards are multiplied many times.", "\n\nBy the way, listening to the Qur'an being read is also just like reading it.", "\n\nThe Prophet had many hadiths on this topic. ", "He often recommended his companions to read the Qur'an and think about the Qur'an.", "\n\nThe Prophet said: _\"The most superior among you [Muslims] are those who learn the Qur'an and teach it.\"_", "\n\nal-Bukhari\n\nAllah's Messenger said: _\"The example of the person who knows the Qur'an by heart is like the owner of tied camels. ", "If he keeps them tied, he will control them, but if he releases them, they will run away.\"_", "\n\nal-Bukhari\n\nThe Prophet said: _\"Keep on reciting the Qur'an, for, by Him in Whose Hand my life is, Qur'an runs away [is forgotten] faster than camels that are released from their tying ropes.\"_", "\n\nal-Bukhari\n\nThe Prophet said: _\"The example of him [a believer] who recites the Qur'an is like that of a citron which tastes good and smells good. ", "And he [a believer] who does not recite the Qur'an is like a date which is good in taste but has no smell.\"_", "\n\nal-Bukhari\n\nThe Messenger said: \" _The one who is proficient in the recitation of the Qur'an will be with the honourable and obedient angels and he who recites the Qur'an and finds it difficult to recite, doing his best to recite it in the best way possible, will have a double reward_.\"", "\n\nMuslim\n\n**Why did Allah use words in the Qur'an?**", "\n\n_We have made it easy, in your own language [Prophet], so that you may bring glad news to the righteous and warnings to a stubborn people._", "\n\nSurah Maryam 19:97\n\nALLAH IS SPEAKING to us in the Qur'an. ", "The words we read are the ones He chose to use. ", "But that makes me think of a question: _Why does Allah use words that are familiar to us? ", "Couldn't He have chosen to speak to us in another way?_", "\n\nI mean, Allah was there when nothing was. ", "He does not need anything. ", "He can do anything.", "\n\nSo, why is the book of Allah so familiar to us? ", "Allah isn't like anything He created, so shouldn't His word be completely different too? ", "Why would he use the words of people?", "\n\n**A book for humanity**\n\nAs our eyes can't see every colour, our ears can't hear every sound. ", "Even if our ears could hear everything, our mind would not understand what it all meant.", "\n\nWe can't hear bees speaking to one another very well. ", "And we can't understand what they say.", "\n\nWhen birds call to each other, it sounds to us like a beautiful song. ", "We don't understand what birds say to each other, we only hear the sounds.", "\n\nEven if you forget about these examples, remember this: we can't even understand another human when they speak a different language.", "\n\nOur ears have been created in a particular way. ", "We only hear some noises. ", "And our hearts and minds only understand things that are familiar to us.", "\n\nIf Allah didn't speak in a way we could understand; if He addressed us in a language that's appropriate to Allah's might, His glory, we wouldn't know what was being said to us.", "\n\nFor us to understand, either we would need to be raised up to a new level, one where we could be spoken to in Allah's language, or Allah, from His compassion and mercy, would need to address us in a language, in a way, that we know.", "\n\nAllah chose to address us in an understandable language. ", "Just like when a mother is talking to her baby, she chooses an understandable language.", "\n\nHave you ever seen a mother talking to her small child?", "\n\nEven if she was the world's most brilliant scientist, a mother will talk to her child in a way the child can understand. ", "She will leave\n\nall her knowledge, all the words she knows, on one side to communicate with her dear child.", "\n\nShe'll say: \"Look, open your mouth! ", "Ahhhhh. ", "Here comes the food!\" ", "She'll tickle her child during play and say: \"Coochie coochie coo.\"", "\n\nSomeone who heard this, but didn't see the mother and child, would not accept that the mother is so clever. ", "They might say: \"This cannot be the world's most brilliant scientist.\"", "\n\nThis is an example to those who say after reading the Qur'an: \"The Qur'an uses words. ", "It sounds similar to our own. ", "If the Qur'an was Allah's word, it wouldn't be like ours. ", "It should be a miraculous thing!\"", "\n\nThey don't understand that Allah is speaking to them in an understandable language for their own good.", "\n\nJust like the people that say: \"Why does the Prophet Muhammad get hungry, get cold, get tired. ", "Shouldn't a prophet be like an angel?\"", "\n\nWho can follow in the footsteps of an angel who doesn't eat, drink or get hungry? ", "Their life wouldn't be an example for us to follow.", "\n\nJust like prophets were sent to be a guide for people, the Qur'an is for humans.", "\n\nIt's for people to understand, get advice from and live according to what they have learned.", "\n\n_This is a message to all people, so that they may be warned by it, and know that He is the only God, and so that those who have minds may take heed._", "\n\nSurah Ibrahim 14:52\n\nYes, the Qur'an sounds familiar to us, because it is meant to be understood.", "\n\nWhat is the point of Allah sending us a book if we could not learn from it? ", "A book that no one could read, or no one could bear to listen to, wouldn't be of any use to us.", "\n\nWe should thank Allah, who sent a book that we can read and understand. ", "A book that guides us, that gives us knowledge that will help us lead good lives and take us away from harm.", "\n\n**The Qur'an: A unique book**\n\nA question such as this may come to you. _", "Since the Qur'an has been sent in a language humans can understand, why is it unique and without equal? ", "Why is it a miracle? ", "Isn't it like other books?_", "\n\nI can see why you might ask that. ", "Let me start by saying this:\n\nWhat do we make out of earth?", "\n\nWe make pots, vases, dishes and mugs.", "\n\nWhat does Allah make out of earth?", "\n\nHe makes fruit, trees, vegetables...\n\nHe makes a rose bush, an olive tree and a plump potato...\n\nHe makes a bird, a sheep and even humans from earth...\n\nHe even makes the earth.", "\n\nCan you see the enormous difference between Allah's skill and our own? ", "What he can do is impossible for us.", "\n\nNow let's think about words.", "\n\nWriters have written stories, poems and songs for thousands of years.", "\n\nWith the same words Allah revealed the Qur'an to the Prophet. ", "No other book is like it.", "\n\nIt soothes people's minds.", "\n\nWhen recited out loud it lifts sad hearts.", "\n\nIt tells us to think about the world. ", "It even includes scientific facts that were unknown when the Qur'an was revealed.", "\n\nIt guides us in this life and teaches us about the next life.", "\n\nIts message has reached billions of people.", "\n\nNothing written before or after it was revealed can compare to it.", "\n\nWhat a good companion the Qur'an is. ", "It is like a sun that brightens our lives.", "\n\n_Alif Lam Mim Ra. ", "These are the signs of the Book. ", "What your Lord has sent down to you [Prophet] is the truth, yet most people do not believe._", "\n\nSurah al-Ra'd 13:1\n\n**Why was the Qur'an revealed over such a long time?**", "\n\n_And it is a recitation that We have revealed in parts, so that you can recite it to people at intervals; We have sent it down little by little._", "\n\nSurah al-Isra 17:106\n\nJUST AS EVERYTHING in the universe was created bit by bit, the Qur'an was revealed verse by verse.", "\n\nThe Qur'an was given to the Prophet Muhammad over 23 years. ", "He was 40 years old when he received the first verse from the Angel Gabriel. ", "The rest came in stages over his life as a messenger.", "\n\nBut why wasn't it revealed all at once?", "\n\nTo understand that, we need to imagine ourselves in Makkah, the place where the first verse of the Qur'an was sent to the Prophet Muhammad.", "\n\nIn Makkah, the people did not have good habits. ", "In fact, some were evil.", "\n\nThey drank alcohol and gambled. ", "All they were interested in was making money. ", "And they would not share it with the poor or help the needy. ", "Worst of all, they buried their newborn daughters in the desert.", "\n\nThe Makkans made idols and worshipped them. ", "They asked them for help and success when they themselves had made them.", "\n\nA book that told them all of this was wrong would not have been a joy to read.", "\n\nFollowing the message of the Qur'an would have meant giving up their bad habits all at once.", "\n\nThat would not have been easy.", "\n\nAnd it would have made the Prophet Muhammad's job much harder.", "\n\nHe would have to memorise the entire Qur'an, at once.", "\n\nHe would have had to ask people to change their whole lives.", "\n\nImagine one morning having to change everything you believed.", "\n\nFollowing Allah's rules would have been very hard for the Makkan people.", "\n\nThey might have stopped trying to follow the new rules or, worse still, turned their backs on the Qur'an altogether.", "\n\n**Change takes time**\n\nInstead, the verses of the Qur'an came bit by bit. ", "Over a long time.", "\n\nThe people of Makkah, and Arabia, could learn each verse off by heart, think about what it meant, and then change their ways.", "\n\nIt was not just given to them like a list of instructions.", "\n\nBoth their minds and hearts were being changed as they learned and absorbed Allah's verses.", "\n\nInstead of having to alter their ways all at once, the people only had to make small changes. ", "What a relief that must have been to them, and a great mercy from Allah.", "\n\nThis way everything they learned stayed with them.", "\n\nIt never left their hearts and minds.", "\n\nIf Allah had wished, of course He could have sent the Qur'an all at once. ", "He created the universe and everything in it. ", "Nothing is too hard for Him.", "\n\nBut, had He sent it all together, the people would have faced great difficulty.", "\n\nThey would have had to remember it all by heart, and try to understand what it all meant.", "\n\nIt would have been like a child, who can barely read, being sent to university. ", "Can you imagine that? ", "They would be sent straight home, without learning a thing.", "\n\nDuring the time of the Prophet, those who hated the Prophet and the Qur'an said things like: \"Why would Allah send His book line by line? ", "He should send it all at once.\"", "\n\nThe answer to their question was given to them in a verse of the Qur'an:\n\n_The disbelievers also say, 'Why was the Qur'an not sent down to him all at once?' ", "We sent it in this way to strengthen your heart [Prophet]; We gave it to you in gradual revelation._", "\n\nSurah al-Furqan 25:32\n\nOther books were also sent before the Qur'an. ", "The Torah was sent to Prophet Moses. ", "The _Injeel_ was sent to Prophet Jesus. ", "But the Qur'an was the last book sent to humankind. ", "So it had to be understood very well and the people had to follow its rules. ", "After all it had to be passed on to people all around the world, until the Day of Judgement.", "\n\nAt the start of the revelations, the people of Makkah were like stones – on the ground and covered in dirt. ", "Due to the lessons they learned from the Qur'an, they were slowly transformed. ", "Twenty-three years later, they were like the stars that shine in the sky.", "\n\nTheir light is still guiding us today.", "\n\n**How do we know that the Qur'an has not been changed?**", "\n\n_We have sent down the Qur'an Ourself, and We Ourself will guard it. ", "Even before you [Prophet]_\n\nSurah al-Hijr 15:9\n\nNOT ONLY MUSLIMS, but many other people, believe the Qur'an has not been changed! ", "People of other religions, people of no religion and even history teachers.", "\n\nIt doesn't matter that the Qur'an was sent 1,400 years ago. ", "It is still the same. ", "It has never changed: not even one chapter, one verse or even one letter.", "\n\nIsn't that an amazing fact?", "\n\nAnd a fact many people believe. ", "Even if they are not Muslim.", "\n\nSome people who don't accept that Muhammad is a prophet, have a deep respect for his life. ", "And there are people who look at the history of the Qur'an and believe it is exactly the same, despite how many years ago it was written.", "\n\n**How has the Qur'an been sent to us?**", "\n\nAngel Gabriel brought Allah's verses to the Prophet. ", "Sometimes the Prophet was able to see the Angel Gabriel. ", "Sometimes he wasn't.", "\n\nThe Prophet would sweat and go pale when the verses were given to him. ", "It could even sound like the ringing of a bell in his head.", "\n\nOnce the Prophet received the verses he instantly memorised them. ", "In fact, he was so careful not to forget them, he repeated the verses many times.", "\n\nThen Allah sent him a verse that removed his fears, and assured him that Allah protected the Qur'an:\n\n_[Prophet], do not rush your tongue in an attempt to hasten [your memorization of] the Revelation._", "\n\nSurah al-Qiyamah 75:16-17\n\n**Scribes and hafiz (memorisers of the Qur'an)**\n\nThe Prophet had many companions that spent as much time as possible with him: observing him; asking him questions; and helping him on his mission.", "\n\nSome of them knew how to read and write. ", "At first, there were only a few but, in time, their number rose to as many as 40. ", "They were called SCRIBES.", "\n\nEach scribe had a special place among the companions. ", "Their most important duty was to write the verses down that came to the Prophet.", "\n\nAs the Prophet didn't know how to read and write, he couldn't do it himself. ", "Instead, his companions did so, as soon as a verse was revealed. ", "This would be good enough for most people, but not the scribes. ", "They would read what they had written to the Prophet to check it was exactly right.", "\n\nAlong with the verses, Gabriel told the Prophet what the order of the verses should be. ", "This was also recorded.", "\n\nYou might wonder, _where did they get paper from to write it down?_ ", "That is an excellent question.", "\n\nThey didn't have any paper.", "\n\nIn that time, the Arabs did not read or write. ", "Instead, everything was remembered and passed from generation to generation by talking.", "\n\nYou might also wonder how this was possible. ", "Well, their memories were very good. ", "In fact, there were some Arabs who could play chess while travelling on a camel, without a board or pieces, just from their imagination. ", "Of course, for a community that had such strong memories, it wasn't very hard to memorise the verses of the Qur'an.", "\n\nHowever, despite their amazing memories, it was still important to write down vital information. ", "They could do this on flat stone slabs, animal skins and date leaves.", "\n\nAs well as scribes, there were also HAFIZ, people who would memorise the Qur'an.", "\n\nThe tradition of memorising the Qur'an is a custom that continues today.", "\n\nHafiz of the Qur'an learn the verses one by one and repeat them often. ", "At the time of the Prophet, there were more hafiz than scribes. ", "Everybody had a good memory, but not many people could read or write.", "\n\nAnd, as you read in the previous chapter, the verses were revealed piece by piece. ", "This made it easier to memorise them.", "\n\nDuring the Prophet's lifetime, the written verses were not brought together to form a book, because the revelations continued. ", "And the verses did not come in the order we read them today.", "\n\nSo, it wasn't known beforehand what the final order would be. ", "If it had been turned into a book, before it was complete, everything would change; a new version would have to be written.", "\n\n**The Qur'an (Mushaf)**\n\nWhen the Prophet passed away, his loyal friend, Abu Bakr, became the head of the Muslim community.", "\n\nDuring Abu Bakr's leadership there were many battles. ", "Lots of Muslims were killed, including the hafiz – the trustworthy people who had memorised the Qur'an.", "\n\nThis situation worried Umar, who would later become a leader of the Muslims. ", "He feared that if hafiz continued to die, there wouldn't be anyone left who knew the Qur'an off by heart!", "\n\nUmar shared this worry with Abu Bakr.", "\n\nTherefore, it was decided that the Qur'an should be turned into a book.", "\n\nZayd b. Thabit, who was both a hafiz and a scribe, was asked to do this job.", "\n\nHe was helped by a team made up of Umar, Ali, Uthman and Ubayy Ibn Ka'ab.", "\n\nThey all carried out the work for exactly one year.", "\n\nAlthough Zayd b. Thabit knew the Qur'an from memory, he didn't sit and write the verses on his own.", "\n\nHe called upon anyone that had learned something of the Qur'an from Allah's Messenger to bring it to him.", "\n\nAnyone who had written a verse brought it to him. ", "And those who had it in memory came and read it to him. ", "Zayd compared the verses that were brought to him and read to him. ", "In the end, all the verses were written on skins and date leaves and put into the same order as it is today.", "\n\nOnce complete, it was read from start to finish twice.", "\n\nThe Qur'an had become a book. ", "It was called MUSHAF (Qur'an).", "\n\nDuring the time of Uthman, Islam's third leader after the Prophet, this book was copied and sent to all the cities of the Islamic empire.", "\n\nToday, in many Muslim countries, there are very old copies of the Qur'an. ", "For example, in a museum in Istanbul, there are Qur'ans that belonged to Uthman and Ali.", "\n\nThere isn't the slightest difference between them and the Qur'ans that are being read today.", "\n\nThe Qur'an was protected and preserved from the time of the Prophet until today. ", "It has stayed the same, thanks to the people that remembered it and wrote it down.", "\n\nThat is how we know a letter has not been changed.", "\n\nAnd it will not be changed until the Day of Judgement, because Allah is protecting it.", "\n\n_We have sent down the Qur'an Ourself, and We Ourself will guard it. ", "Even before you [Prophet]._", "\n\nSurah al-Hijr 15:9\n\n**Science in the Qur'an**\n\nALLAH MENTIONS THE universe in the Qur'an a lot. ", "But why?", "\n\nBecause He wants us to think, look and reflect on the world around us. ", "He talks about animals, plants, mountains and much more.", "\n\nWhen reading the Qur'an we think about the universe; and when examining the universe we should think of the Qur'an.", "\n\nFor example, read this verse from the Qur'an:\n\n_And your Lord inspired the bee, saying, \"Build yourselves houses in the mountains and trees and what people construct...\"_\n\nSurah Al-Nahl 16:68\n\nIt makes you think of bees flying in front of our eyes.", "\n\nWhenever we decide to eat a spoon full of honey another verse about honey bees should come to mind:\n\n_From their bellies comes a drink of different colours in which there is healing for people. ", "There truly is a sign in this for those who think._", "\n\nSurah Al-Nahl 16:69\n\nCan you see that the Qur'an and the universe are two books of Allah that should never be separated from each other?", "\n\nThe Qur'an's verses tell us about the miracles of the universe. ", "They inform us about stars, clouds, thunder, bees, ants and even our adventures in our mother's womb.", "\n\nAnd as we learn the secrets of nature we understand the verses of the Qur'an better.", "\n\nFor example, scientists studying bees have discovered that honey starts off as a 'drink' from the bellies of bees, and about all the goodness of honey for humans.", "\n\nScientists looking at the planets in the universe discovered they follow orbits. ", "Well, listen to what the Qur'an said 1400 years ago about this:\n\n_It is He who created night and day, the sun and the moon, each floating in its orbit._", "\n\nSurah Al-Anbiyaa 21:33\n\nThis is one of the greatest miracles of the Qur'an. ", "It shows that as time passes the Qur'an doesn't get old; as a matter of fact it gets younger.", "\n\n**Is the Qur'an a book of science?**", "\n\nWhen the Qur'an talks about the world it isn't to explain scientific facts. ", "It is to draw your attention to Allah's wonderful workmanship.", "\n\nIf it mentions the stars, it mentions them to show Allah's might.", "\n\nIf it mentions honeybees, it mentions them so we can see the complexity of Allah's creation.", "\n\nThis is because the Qur'an is a holy book first. ", "Its main purpose is to introduce us to Allah and inform us of Him.", "\n\nIt orders us to think, to look and to reflect on the universe to understand Allah and His Qur'an!", "\n\n_\"There truly is a sign in this for those who think.\"_", "\n\nSurah Al-Nahl 16:69\n\nThe Qur'an doesn't say, \"This is how these things happen...\" like a biology book, a chemistry book or a geography book.", "\n\nThe Qur'an tells us to think and to look at the world for ourselves.", "\n\nFor this reason, reading the Qur'an will not make you a biologist, a chemist or a geologist. ", "To be one of those you have to carry out experiments, conduct research and make observations about the world.", "\n\nMany great Muslim scientists of the past were inspired to do just that.", "\n\nDo you wonder what they achieved?", "\n\n**Great Muslim Scientists**\n\nHundreds of years ago cities all over the Muslim world were full of great scientists.", "\n\nThey were scientists who read the Qur'an and studied the universe. ", "For centuries their discoveries amazed people.", "\n\nThey said, \"Doesn't the Qur'an order us to look, think and reflect on His creation? ", "Since there are so many verses about the universe in the Qur'an shouldn't we look at them side by side?\"", "\n\nLet's learn about a few of these amazing people.", "\n\n**'Abbas ibn Firnas (810–887):** More than 1000 years ago, he made an early parachute jump and leaped off the Great Mosque of Cordoba, Spain, wearing a reinforced cloak.", "\n\n**Al-Battani (858–929):** He was one of the most influential figures in trigonometry, a branch of maths. ", "He is considered to be one of the greatest Muslim astronomers and mathematicians.", "\n\n**Al-Biruni (973–1052):** He discussed the theory of the Earth rotating around its own axis, 600 years before a scientist called Galileo talked about it in Europe.", "\n\n**Al-Idrisi (1100–1166):** In 1154, he finished the first map that showed most of North Africa, Asia, and Europe.", "\n\n**Al-Khwarizmi (780–850):** He is the father of algebra, a type of mathematics that uses letters and numbers.", "\n\n**Fatima al-Fihri (d. 880):** She used her fortune to build the Al-Qarawiyyin mosque and a school in Morocco 1,200 years ago. ", "This is the world's oldest active university.", "\n\n**Ibn al-Haytham (965–1040):** He revolutionised optics, the science of light and sight. ", "He was the first to prove that vision is caused by light reflecting off an object and entering the eye.", "\n\n**Ibn Sina (980–1037):** As a doctor and philosopher, he developed a method of treating fractured bones that is still used today. ", "He is considered the father of modern medicine.", "\n\n**Jabir ibn Hayyan (721–815):** He was known in the west as Geber, and he is the founder of chemistry. ", "All his experiments were carried out in his laboratory in Kufa, which is now in Iraq.", "\n\n**Al-Jahiz (779–869):** He was a pioneer in zoology and wrote a seven-volume _Book of Animals_ , which had observations on ants, communication between animals and food chains.", "\n\n**Al-Zahrawi (936–1013):** This Spanish Muslim surgeon is considered the father of modern surgery. ", "He produced many of the medical instruments that continue to be used, like the scalpel for cutting.", "\n\nLook what kind of fruits grow when the Qur'an and the universe are read together at the same time!", "\n\n**Why does it say: \"Will they not then consider the camels... ?\" ", "in the Qur'an?**", "\n\n_Will they not then consider the camels, how they are created?_", "\n\nSurah al-Ghashiyah 88:17\n\nTHE QUR'AN IS full of meaning. ", "Allah has sent it down to guide us to what is right and away from what is wrong.", "\n\nHowever, sometimes it isn't clear what the Qur'an is telling us straight away.", "\n\nIf you are like me, then you wonder about those verses in the Qur'an you don't understand. ", "I wondered why the Qur'an asks: \"Will they not then consider the camels\"?", "\n\nBefore we look at this verse, let us first think about the people who first heard it. ", "They were Arabs from Makkah and Madinah. ", "And camels were essential for them. ", "So the Arabs would have been thinking about camels every day, even if you aren't where you live.", "\n\nSo, why then in the Qur'an is it asked: \"Will they not then consider the camels\"?", "\n\nThe Arabs at the time of the Prophet did consider camels. ", "They rode them, ate the meat of them, drank the milk from them, used their skin for leather and made them carry their loads.", "\n\nHowever, camels didn't remind the people of their Creator. ", "They didn't think of Allah, who created such an amazing animal: an animal that can survive in a dry desert with hardly anything to drink.", "\n\nThey didn't thank Him for this great blessing. ", "Instead, they took their camels for granted.", "\n\nAfter riding them through the desert, they would dismount them and go to kneel before idols made out of stone and wood. ", "Some would even sacrifice their camels to the idols.", "\n\nThey used camels every day, but didn't consider their beautiful and amazing Creator. ", "This might have been because they didn't know Allah or because they didn't accept that the camel had been created by Allah.", "\n\nYet the verse wants us to think about this: \"Will they not then consider the camels, how they are created?\"", "\n\nConsidering the camels means thinking about how they were created and remembering who created them.", "\n\nThe Prophet was the guide for all Muslims. ", "When it comes to understanding the Qur'an, his actions are very helpful.", "\n\nOne day a companion asked Aisha, a wife of the Prophet, about the manners of the Prophet.", "\n\nShe replied: \"Have you not read the Qur'an? ", "The morals of the Prophet are the same.\"", "\n\nHe was like a living Qur'an.", "\n\nI wondered how the Prophet considered the camels. ", "After flicking through a few books, I found a prayer the Prophet made when mounting a camel:\n\n_\"Glory be to Him who has given us control over this; we could not have done it by ourselves\"._", "\n\nSurah al-Zukhruf 43:13\n\nSo, this is how you can consider a camel in the way the Qur'an wants. ", "If only there was a camel, so we could say it...\n\n**What can we learn from this verse?**", "\n\nToday, we don't travel on camels.", "\n\nMost of us haven't even seen a real camel. ", "So what does this verse mean for us? ", "And how can we use the Prophet's prayer?", "\n\nWell, even if we are not travelling on camels, we can get in cars, planes, trains and ships to travel around.", "\n\nAll of these things are blessings from Allah. ", "We can get in these vehicles and travel over land, sea and through the air. ", "They are made using the materials that Allah created. ", "What's more, we fill them up with fuel that has been created by Allah. ", "So, we should be thankful to Allah for them.", "\n\nThe prayer the Prophet made when getting on a camel can easily be said when getting in these vehicles.", "\n\n_\"Glory be to Him who has given us control over this; we could not have done it by ourselves\"._", "\n\nSurah al-Zukhruf 43:13\n\nWe need to remember that the Qur'an doesn't just want us to consider a camel and how it was created. ", "It also wants us to consider how the skies were raised up, how mountains were fixed, how the earth spread and much more.", "\n\nSo let's remember Allah who filled our world with beauty and thank Him.", "\n\n**Why is the name of the longest surah in the Qur'an _al-Baqarah_ (the cow)?**", "\n\n_Remember when Moses said to his people, \"God commands you to sacrifice a cow.\" ", "They said, \"Are you making fun of us?\" ", "He answered, \"God forbid that I should be so ignorant.\"_", "\n\nSurah al-Baqarah 2:67\n\n_BAQARAH_ MEANS COW in Arabic. ", "And yes, the name of the longest surah in the Qur'an is _al-Baqarah_ (the cow).", "\n\nBut don't look for Surah _The Cow_ because you probably won't find it. ", "In a translation of the Qur'an, the surah names are not translated. ", "They are like the names of people (proper nouns).", "\n\nIf your parents name you Yasser, it does not change when you visit another country. ", "Even though Yasser means 'to be well off' in English, no one would start calling you 'to be well off' in England!", "\n\nYou will also not find Surah _al-'Ankabut_ written as 'The Spider'; or Surah _al-Nahl_ as 'The Bee'. ", "And 'The Star' isn't written instead of Surah _al-Najm_ and 'The Moon' instead of _al-Qamar_.", "\n\nAnother reason is because none of these surahs only talk of a spider, a bee, a star or the moon.", "\n\nThey take these 'special' names because of parts in each surah that cover these subjects.", "\n\nThe longest surah of the Qur'an, _al-Baqarah,_ doesn't speak just of the cow. ", "It covers so many subjects. ", "We would need another book just to list _some_ of them.", "\n\nYet Surah _al-Baqarah_ does inform us of the 'cow incident', from verse 67 to verse 71.", "\n\n_What is so special about this cow incident that a surah has been named after it?_", "\n\nWell, a lot actually. ", "It talks about a cow being killed, but there is so much more to it.", "\n\n**Slaughtering the cow**\n\nWe need to go back to the Prophet Moses' time.", "\n\nOne night, a rich man living amongst the Sons of Israel was killed by his own nephew. ", "But no one knew who the murderer was.", "\n\nThe next day, a group of people gathered around the man who had died. ", "And that wicked nephew started shouting and said he wanted revenge.", "\n\nThey asked the Prophet Moses to tell them what to do.", "\n\nProphet Moses said to them: \"God commands you to sacrifice a cow.\"", "\n\nThe Sons of Israel were surprised. ", "They asked: \"Are you making fun of us?\"", "\n\nProphet Moses wasn't joking.", "\n\nHe said: \"God forbid that I should be so ignorant.\"", "\n\nWhat shocked and scared the Sons of Israel wasn't that Allah wanted them to kill a cow to find out who the murderer was. ", "What was hard for them was to slaughter the cow.", "\n\nBecause, before the murder, when Prophet Moses had left for a short time to visit Mount Tur in Egypt, they had started worshipping cows. ", "Just like they had before, when the Sons of Israel were living in the country of Egypt.", "\n\nIn Egypt they worked on the land like everyone else.", "\n\nCows and cattle were essential for them.", "\n\nCows would plough their fields and carry their crops.", "\n\nThe people were very grateful to cows.", "\n\nOver time, this gratitude turned into something else. ", "Cows became holy animals.", "\n\nThey declared them as gods and started worshipping them.", "\n\nThe Sons of Israel, who had fled the Pharaoh with Prophet Moses, faced hardship in the desert and started to miss their time in Egypt.", "\n\nThey craved the old ways, and the things they had: jobs, land and cows.", "\n\nDuring this time, Prophet Moses went to Mount Tur in Egypt for some time, leaving them alone.", "\n\nWhen he left, a man called Samiri took advantage. ", "He made a golden sculpture of a calf. ", "This sculpture also mooed like a cow.", "\n\nThe people of Israel immediately gathered around the cow sculpture Samiri had made. ", "And, after some time, they started to worship it.", "\n\nWhen Prophet Moses came back from Mount Tur, he couldn't believe it. ", "He had explained the oneness of Allah to them for years!", "\n\nAt this point, Allah ordered them to slaughter a cow.", "\n\nThey couldn't immediately find a cow to slaughter. ", "They couldn't bring themselves to do it. ", "After all, cows were special to them.", "\n\nThey started asking Prophet Moses what kind of a cow it had to be, secretly hoping to delay what had to be done.", "\n\n_They said, \"Call on your Lord for us, to show us what sort of cow it should be.\" ", "He answered, \"God says it should be neither too old nor too young, but in between, so do as you are commanded.\"_", "\n\n_They said, \"Call on your Lord for us, to show us what colour it should be.\" ", "He answered, \"God says it should be a bright yellow cow, pleasing to the eye.\"_", "\n\n_They said, \"Call on your Lord for us, to show us [exactly] what it is: all cows are more or less alike to us. ", "With God's will, we shall be guided.\"_", "\n\n_He replied, \"It is a perfect and unblemished cow, not trained to till the earth or water the fields.\" ", "They said, \"Now you have brought the truth,\" and so they slaughtered it, though they almost failed to do so._", "\n\nSurah al-Baqarah 2:68–71\n\nIn the end, they did it. ", "They slaughtered a cow, though \"they almost failed to do so.\"", "\n\nThen, Allah ordered them to hit the dead body of the person who had been murdered with part of the slaughtered cow's meat. ", "Once they did this, a miracle occurred. ", "The dead person came to life and told the people who the murderer was.", "\n\n**Worship Allah alone**\n\nThe people in the story had stopped believing in Allah and started worshiping a cow.", "\n\nIt might not cross your mind to worship cows. ", "But a cow is a symbol. ", "Everything that comes between Allah and you is actually a holy cow.", "\n\nWe all have one or more cows we need to give up.", "\n\nAnd, unless we give them up, they will remain between us and Allah and continue to moo.", "\n\nFor example, television that kills time is a cow for most of us. ", "It stays between us and Allah.", "\n\nWe miss _salah_ times and ignore our jobs; sitting there lazily when we could be helping our parents or playing with friends.", "\n\nIf we spend most of our time in front of the TV, it just keeps on mooing.", "\n\nWe don't have time to read the Qur'an and busy ourselves with useful books.", "\n\nIn this way, the TV will remain in front of us like Samiri's mooing cow.", "\n\nOnce in a while, we should 'cut' it out of our lives.", "\n\nAnd we shouldn't make up excuses to keep bad things like the Sons of Israel did.", "\n\nNow, try and count the cows you see around you.", "\n\nSee how the cow in Surah _al-Baqarah_ came and found its place in our lives.", "\n\nThe name of the longest surah of the Qur'an is full of wisdom. ", "I hope now you can see it.", "\n\n**The Dictionary of the Qur'an**\n\n**QUR'AN** : The Muslim holy book. ", "Sent to humanity through the last Prophet, Muhammed.", "\n\nAs Muslims believe no other prophets will come, they also believe no other books will come either.", "\n\nNot even one word in the Qur'an has been changed since the day it was sent.", "\n\nThe Qur'an has other names too. ", "In the Qur'an, Allah calls it _Kitab_ \"Book\". _", "Furqan_ is another one of the Qur'an's names. ", "It means the one that separated truth from lies, right from wrong, unlawful (haram) from lawful (halal), good from bad. ", "Another name for the Qur'an is _Shifa_ , because it heals hearts. ", "And _Hakim_ (Wise) is another one of the Qur'an's well-known names. ", "Sometimes the Qur'an is called _Qur'an-i Hakim_. ", "Hakim means wise and the source of wisdom.", "\n\n**MUSHAF** : This means pages gathered between two covers. ", "It is another name of the Qur'an.", "\n\n**REVELATION** : Knowledge sent from Allah. ", "Normally shared with prophets by the Angel Gabriel (the angel of revelation).", "\n\n**GABRIEL** : There are four great angels: Michael, Israfel, Malak al-Mawt (Angel of Death) and Gabriel. ", "These four great angels have different duties. ", "Gabriel is the ANGEL OF REVELATION, whose job is to take revelations from Allah to a prophet.", "\n\n**SURAH** : The Qur'an is made up of 114 chapters. ", "These chapters are called surahs. ", "All of the surahs, except one, start with the Basmala – In the name of Allah, the Lord of Mercy, the Giver of Mercy.", "\n\nEach surah has a different name. ", "These names are to do with the topics that are mentioned in them.", "\n\nFor example, one surah is called _al-Ankabut_. _", "Al-Ankabut_ means 'the spider'. ", "In this surah there is a verse about a spider. ", "And Surah Yusuf takes its name from the verses in the chapter that refer to the Prophet Yusuf.", "\n\nThe most well-known surah is _al-Fatihah_. ", "This is the first surah of the Qur'an and is the most often read part of the Qur'an. ", "Muslims cannot pray without reading _al-Fatihah_ at least twice.", "\n\nThe longest surah is _al-Baqarah_ , which has 286 verses. ", "The shortest one is _al-Kawthar_ (The Heavenly Fount). ", "It has three verses.", "\n\n**VERSE** : Surahs (chapters) are made up of verses. ", "A verse is like a sentence of the Qur'an. ", "Some sentences are long, some are very short. ", "The Qur'an was revealed verse by verse over 23 years. ", "In the first 13 years, the Prophet was in Madinah; the other 10 years were spent in Madinah. ", "Verses sent to the Prophet in Makkah are called Makki, and verses sent in Madinah are called Madani.", "\n\n**JUZ (CHAPTER)** : The Qur'an is split into 30 parts, or Juz. ", "Many Muslims read the Qur'an part by part.", "\n\n**HAFIZ (MEMORISER OF THE QURAN)** : People who know the Qur'an off by heart are called hafiz. ", "The profession of being a hafiz has existed since the Prophet's times. ", "The companions memorised every verse that was revealed. ", "And they taught the verses to students, and so on, until thousands of people had memorised the Qur'an.", "\n\n**KHATM (COMPLETING THE RECITATION OF THE QUR'AN)** : Reciting the Qur'an from start to finish is called a khatm. ", "This is a sunnah of the Prophet, an action he performed. ", "Every year, especially during the month of Ramadan, he read all the verses of the Qur'an with the Angel Gabriel.", "\n\nWhen all of the Qur'an had been revealed, they did this twice. ", "They read the Qur'an to each other and listened to be sure that the Qur'an was completed and accurate. ", "A short time after, the Prophet left the world, leaving two great items, his sunnah (actions and deeds) and the Qur'an itself.", "\n\nToday, Muslims continue the tradition of completing the Qur'an, especially during the month of Ramadan.", "\n\n**MEANING** (of the Qur'an): A translation of the Qur'an from Arabic, which is the original language, into another language is called the meaning. ", "The meaning and the Qur'an are not the same things. ", "So the translations cannot replace the Arabic Qur'an.", "\n\n**TAFSIR** : Books that explain the verses of the Qur'an. ", "During the history of Islam, thousands of volumes of _tafsirs_ have been written.", "\n\n**About the author**\n\nÖZKAN ÖZE WAS born in Turkey in 1974. ", "While at high school, he started working at Zafer magazine's editorial office in Istanbul and discovered his love of literature and books. ", "Since then he has gone on to become the editor of Zafer Publications Group and continually writes. ", "He is married with two children.", "\n\nÖzkan wrote the \"I Wonder About Islam\" series because he believes that questions are prayers. ", "Asking one is like saying, \"Teach me to understand.\" ", "They act as keys that lead us through doors to new worlds that are more interesting and beautiful than we thought possible.", "\n\n**The \"I Wonder About Islam\" series**\n\nThe \"I Wonder About Islam\" series give young readers answers to the BIG questions they have about Islam in brilliant little books. ", "Written in a friendly and accessible style for today's youth, they are essential companions for questioning young minds.", "\n\n**Books in the \"I Wonder About Islam\" series:**\n\nI Wonder About Allah (Book One)\n\nI Wonder About Allah (Book Two)\n\nI Wonder About the Prophet (Book Three)\n\nI Wonder About the Qur'an (Book Four)\n\n" ]

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[ "What was done\nIn a study germane to this subject, Fleitmann et al. ", "developed high-resolution stable isotope records from three contemporaneously-deposited stalagmites located in a shallow cave in Southern Oman that provide an annually-resolved record of Indian Ocean monsoon rainfall over the past 780 years.", "\n\nWhat was learned\nOver the last eight decades of the 20th century, when global temperatures rose at a rate described by climate alarmists as \"unprecedented,\" Indian Ocean monsoon rainfall declined dramatically, in stark contrast to what has historically been predicted by most climate models. ", "In addition, the other single most substantial decline in monsoon rainfall coincided with a major temperature spike identified by Loehle (2004) in the temperature records of Keigwin (1996) and Holmgren et al. (", "1999, 2001) that began sometime in the early 1400s. ", "This abrupt warming, which has also been identified by McIntyre and McKitrick (2003), pushed temperatures above the peak warmth of the 20th century before they fell back to pre-spike levels in the mid-1500s, a trend that produced just the opposite trend in the monsoon rainfall record of Fleitmann et al., ", "i.e., an initial dramatic decline in monsoon rainfall followed by a subsequent dramatic increase.", "\n\nWhat it means\nThese real-world observations provide a strong double-barreled confirmation that global temperature variations elicit just the opposite variations in Indian Ocean monsoon rainfall than what is predicted by global climate models." ]

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[ "1. ", "Field of the Invention\nIn particular, the present invention describes an apparatus for performing arithmetic and logical operations using a single control signal to manipulate multiple data elements. ", "The present invention allows execution of shift operations on packed data types and also allows execution of alignment operations.", "\n2. ", "Description of Related Art\nToday, most personal computer systems operate with one instruction to produce one result. ", "Performance increases are achieved by increasing execution speed of instructions and the processor instruction complexity; known as Complex Instruction Set Computer (CISC). ", "Such processors as the Intel 80286(trademark) microprocessor, available from Intel Corp. of Santa Clara, Calif., belong to the CISC category of processor.", "\nPrevious computer system architecture has been optimized to take advantage of the CISC concept. ", "Such systems typically have data buses thirty-two bits wide. ", "However, applications targeted at computer supported cooperation (CSCxe2x80x94the integration of teleconferencing with mixed media data manipulation), 2D/3D graphics, image processing, video compression/decompression, recognition algorithms and audio manipulation increase the need for improved performance. ", "But, increasing the execution speed and complexity of instructions is only one solution.", "\nOne common aspect of these applications is that they often manipulate large amounts of data where only a few bits are important. ", "That is, data whose relevant bits are represented in much fewer bits than the size of the data bus. ", "For example, processors execute many operations on eight bit and sixteen bit data (e.g., pixel color components in a video image) but have much wider data busses and registers. ", "Thus, a processor having a thirty-two bit data bus and registers, and executing one of these algorithms, can waste up to seventy-five percent of its data processing, carrying and storage capacity because only the first eight bits of data are important.", "\nAs such, what is desired is a processor that increases performance by more efficiently using the difference between the number of bits required to represent the data to be manipulated and the actual data carrying and storage capacity of the processor." ]

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[ "Drawstring Ruffle Trim Shorts\n\nWe could seriously live in the Drawstring Ruffle Shorts if we could. ", "These shorts come with an elasticized waistband with drawstring, flouncy shape and ruffle trimmed hem. ", "Available in black and white. ", "Fully lined." ]

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[ "A portable Internet system based on Institute of Electrical and Electronics Engineers (IEEE) 802.16e standard uses a wide frequency bandwidth and thus transmits much data for a short time. ", "Moreover, all users can efficiently use a channel by sharing the channel.", "\nData transmission/reception between a Mobile Station (MS) and a Radio Access Station (RAS) is performed by the Orthogonal Frequency Division Multiplexing (OFDM) scheme or the Orthogonal Frequency Division Multiple Access (OFDMA) scheme, and the mobility of the mobile station is supported by a multi-cell structure.", "\nFIG. ", "1 is a diagram schematically illustrating a configuration of a portable Internet system.", "\nReferring to FIG. ", "1, when a mobile station 110 moves from a cell area 130 of a serving RAS 120, to which service is being provided currently, to cell areas 131 and 132 of other RASs 121 and 122, a portable Internet system prevents service provided to the mobile station 110 from being stopped by performing handover.", "\nIn the portable Internet system, a mobile station performs cell reselection, handover decision and initiation, synchronization with a target RAS, and ranging, upon handover. ", "Upon handover, a mobile station is required to transmit/receive information regarding handover to/from a serving RAS and a target RAS, and thus, delay occurs. ", "Herein, transmission of fast ranging information message (hereinafter referred to as fast ranging IE) corresponds to a fast ranging operation for minimizing delay due to ranging, among operations associated with handover.", "\nWhen a handover procedure defined in IEEE 802.16e standard is normally performed, fast ranging is capable of being performed. ", "However, a mobile station decides handover, and thereafter arbitrarily decides handover initiation, or handover initiation can be delayed due to another cause. ", "In this case, handover is performed between a mobile station and a target RAS after an action time, and thus, the mobile station cannot receive fast ranging IE transmitted by the target RAS. ", "At this point, a fast ranging operation is not performed, causing the delay of handover.", "\nAlso, when a signal state of a serving RAS is rapidly changed or very bad during a handover decision and initiation operation, a mobile station cannot exchange a message with the serving RAS. ", "In this case, a message transmitted/received between the mobile station and the serving RAS is omitted, causing the delay of handover.", "\nMoreover, when the signal state of the serving RAS is well changed and thus handover is not required, handover is cancelled during the handover decision operation, and the mobile station can continuously communicate with the serving RAS. ", "However, since an action time for the transmission of fast ranging IE is decided during the handover decision operation, the target RAS allocates fast ranging IE to the action time irrespective of a state between the mobile station and the serving RAS, and thus, a wireless resource can be wasted." ]

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[ "Q:\n\nIs there a \"science-optional\" tag?", "\n\nSometimes people come in with a question tagged science-based that really isn't rooted in science at all, but uses some of the terms, like Star Trek tech speak. ", " It was really noticeable to me in a recent question about storing a black hole in an ice cream truck.", "\nNow I'm all for creativity. ", " If Dippin Dots can find an excuse to use liquid nitrogen, I'm interested in what you might be able to do with the time dilation around a black hole to get that creamy texture just right! ", " However, when I look at the question, the only thing actually scientific about it is the words \"black hole.\" ", " Everything else about it is pseudoscience at best, unadulterated by pesky real physics.", "\nWe have hard-science for questions where we want real citations and mathematics, and science-based for questions which don't need such citations, but we're still looking for basic physics. ", " Might it be useful to introduce a science-optional or science-ish tag for use when you don't want to have to deal with anything like reality in your question but still want something that sounds like good \"tech-speak\" from a sci-fi script? ", " I personally value good science better than tech-speak, but I'll readily admit that tech-speak has its place and is valuable. ", " There are entire franchises whose illusion of science has ridden on the backs of such tech-speak!", "\nI can't speak for every world builder out there, but I have trouble answering these science based questions unless they are at least remotely base-able in science.", "\nIt also seems like a nice place to put the questions that come in the form \"Can you give me a scientific basis for my world which lacks any scientific riggor because it has some funny feature that breaks everything?\" ", " I can see an especially high value in being able to discuss made up technologies which a skilled physicist could prove creates an infinite source of energy, something which is an anathema in anything related to science. ", " Authors can often side-step those pesky singularities, while science stares them down straight in their face.", "\n\nA:\n\nThe \"science-optional\" tag would work well for questions where the limits of science are pushed beyond what is known. ", "However, the proposed term for the tag is somewhat too ambivalent and unclear.", "\nThis problem had already been faced by science-fiction in the nineteen-thirties and their solution was to call hypothetical sciences and technologies \"super-science\". ", "The \"super\" part simply meant \"higher\". ", "So if authors wanted time-machines or faster-than-light travel this was considered to be legitimated as super-science. ", "If time-machines were considered as impossible by current science (say, the 1930s), then their time-machines operated on super-scientific principles as yet undiscovered in the 1930s. ", "The same justification can be applied in subsequent decades by authors in their science-fiction and correspondingly accepted by readers. ", "Aware persons will realize that although this was called \"science-fiction\" it might have been better called \"super-science-fiction\". ", "Certainly the term was used even into the nineteen-fifties and was part of names of some science-fiction magazines.", "\nThis isn't the only option for the name of a \"science-optional\" tag. \"", "Pseudoscience\" is another possibility, but that is better employed to describe truly bad and fake science. ", "The \"pseudo\" of pseudoscience means \"false\". ", "\n\"Parascience\" has been used as a somewhat more respectable term for pseudoscience and is often used in areas where science is uncertain. ", "For example, with telepathy , psychokinesis, precognition, extra-sensory perception when these phenomena are studied scientifically this is called para-psychology. ", "The parasciences might be considered as sciences where the evidence is often fuzzy, uncertain and even plain dubious. ", "Not quite sciences, but lurking on the fringes of being possible sciences. \"", "the \"para\" part from the Greek and adds the meaning of \"beside\", \"beyond\", \"wrong, irregular\", especially in scientific terms. ", "So parapsycholgy can simultaneously mean psychology that is beside psychology, beyond psychology as we know it, and wrong or irregular psychology. ", "Presumably, depending on how legitimate you consider parapsychology as science.", "\nBrian Stableford coined the term \"metascience\" in his 1979 novel The Walking Shadow. ", "Looking at its Greek roots, the meta part of a word adds the meaning of \"with\", \"after\", and \"change\". ", "Metascience, therefore, can mean that it is with science, while being after science, consequently a more advanced version of science, and science which has been changed.", "\nThe three possible terms for a \"science-optional\" tag all have meanings suggesting they go beyond science as is it currently known. ", "Super-science goes back to science-fiction's pulp magazine roots. ", "While \"higher-science\" gives a conceptually plausible foundation for science beyond expected science, it is possibly too florid and extravagant for a WB tag. ", "Parascience have an unfortunate association with pseudoscience, but has good etymological roots. ", "Metascience is somewhat uncontaminated by unfortunate associations, but persuading people to wrap their minds around the concept clearly and unequivocally might be difficult.", "\nA further alternative term is the phrase \"scientific verisimilitude\" and is sometimes used for science-fiction where various literary devices (time-machines, force-fields, FTL travel) are described in ways they make them seem as if they could apparently be scientific phenomena. ", "OK this usually hand-waving to fill in the gaps between what we know scientifically and what is needed to make the phenomena (no matter how unrealistic they might be in terms of legitimate science) plausible. ", "Sometimes, the term \"scientific plausibility\" is used, but this can be confusing when it's used in a hard-science SF context where this means conforming to proper science.", "\nScientists will refer to \"hand-waving\". ", "This basically means let's just assume something we don't know whether it's real or not and may not even exist is, for the sake of the argument, real. ", "This is a conceptual process. ", "By contrast, handwavium is a conceptual bastardization and should be put upside against a wall and summarily executed, have a stake driven through its black heart, cremated to ashes and buried at sea. ", "You're quite right, handwavium does play well for this little black duck. ", "Hand-waving as such is fine.", "\nThe reason for suggesting several alternative terms for a \"science-optional\" tag is to provide possible concepts and their related terms to describe them as a starting point for such a tag could be constructed (assuming the site wants to adopt one).", "\n\n" ]

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[ "Q:\n\nSpriteKit drag and drop through wall\n\nI did simple drag and drop in SpriteKit with physics. ", "It works as expected, but when I use fast drag, element goes through wall. ", "\nself.runner is wall \nself.runner2 is square\nWall have dynamic set to NO. ", "\nMovie shows everything: https://www.dropbox.com/s/ozncf9i16o1z80o/spritekit_sample.mov?dl=0\nTested on simulator and real device, both iOS 7. ", "\nI want to prevent square from going through wall. ", "Any ideas? ", "\n#import \"MMMyScene.h\"\n\nstatic NSString * const kRunnerImg = @\"wall.png\";\nstatic NSString * const kRunnerName = @\"runner\";\n\nstatic NSString * const kRunnerImg2 = @\"zebraRunner.png\";\nstatic NSString * const kRunnerName2 = @\"runner\";\n\nstatic const int kRunnerCategory = 1;\nstatic const int kRunner2Category = 2;\nstatic const int kEdgeCategory = 3;\n\n@interface MMMyScene () <SKPhysicsContactDelegate>\n\n@property (nonatomic, weak) SKNode *draggedNode;\n@property (nonatomic, strong) SKSpriteNode *runner;\n@property (nonatomic, strong) SKSpriteNode *runner2;\n\n@end\n\n@implementation MMMyScene\n\n-(id)initWithSize:(CGSize)size { \n if (self = [super initWithSize:size]) {\n self.backgroundColor = [SKColor colorWithRed:0.15 green:0.15 blue:0.3 alpha:1.0];\n\n self.runner = [SKSpriteNode spriteNodeWithImageNamed:kRunnerImg];\n self.runner.texture = [SKTexture textureWithImageNamed:kRunnerImg];\n [self.runner setName:kRunnerName];\n\n [self.runner setPosition:CGPointMake(160, 300)];\n [self.runner setSize:CGSizeMake(320, 75)];\n [self addChild:self.runner];\n\n self.runner.physicsBody = [SKPhysicsBody bodyWithRectangleOfSize:CGSizeMake(320, 75)];\n self.runner.physicsBody.categoryBitMask = kRunnerCategory;\n self.runner.physicsBody.contactTestBitMask = kRunner2Category;\n self.runner.physicsBody.collisionBitMask = kRunner2Category;\n self.runner.physicsBody.dynamic = NO;\n self.runner.physicsBody.allowsRotation = NO;\n\n self.runner2 = [SKSpriteNode spriteNodeWithImageNamed:kRunnerImg2];\n [self.runner2 setName:kRunnerName2];\n\n [self.runner2 setPosition:CGPointMake(100, 100)];\n [self.runner2 setSize:CGSizeMake(75, 75)];\n\n self.runner2.physicsBody = [SKPhysicsBody bodyWithRectangleOfSize:CGSizeMake(75, 75)];\n self.runner2.physicsBody.categoryBitMask = kRunner2Category;\n self.runner2.physicsBody.contactTestBitMask = kRunnerCategory;\n self.runner2.physicsBody.collisionBitMask = kRunnerCategory;\n self.runner2.physicsBody.dynamic = YES;\n self.runner2.physicsBody.allowsRotation = NO;\n\n [self addChild:self.runner2];\n\n self.physicsBody = [SKPhysicsBody bodyWithEdgeLoopFromRect:self.frame];\n self.physicsBody.categoryBitMask = kEdgeCategory;\n self.physicsBody.collisionBitMask = 0;\n self.physicsBody.contactTestBitMask = 0;\n self.physicsWorld.gravity = CGVectorMake(0,0);\n self.physicsWorld.contactDelegate = self; \n }\n\n return self;\n}\n\n- (void)didBeginContact:(SKPhysicsContact *)contact {\n SKPhysicsBody *firstBody, *secondBody;\n\n firstBody = contact.bodyA;\n secondBody = contact.bodyB;\n\n if(firstBody.categoryBitMask == kRunnerCategory )\n {\n NSLog(@\"collision\");\n //self.draggedNode = nil;\n\n }\n}\n\n- (void)didMoveToView:(SKView *)view {\n UIPanGestureRecognizer *gestureRecognizer = [[UIPanGestureRecognizer alloc] initWithTarget:self action:@selector(handlePanFrom:)];\n [[self view] addGestureRecognizer:gestureRecognizer];\n}\n\n- (void)panForTranslation:(CGPoint)translation {\n CGPoint position = [self.draggedNode position];\n if([[self.draggedNode name] isEqualToString:kRunnerName]) {\n [self.draggedNode setPosition:CGPointMake(position.x + translation.x, position.y + translation.y)];\n }\n}\n\n- (void)handlePanFrom:(UIPanGestureRecognizer *)recognizer {\n if (recognizer.state == UIGestureRecognizerStateBegan) {\n CGPoint touchLocation = [recognizer locationInView:recognizer.view];\n touchLocation = [self convertPointFromView:touchLocation];\n [self selectNodeForTouch:touchLocation];\n }\n else if (recognizer.state == UIGestureRecognizerStateChanged) {\n CGPoint translation = [recognizer translationInView:recognizer.view];\n translation = CGPointMake(translation.x, -translation.y);\n [self panForTranslation:translation];\n [recognizer setTranslation:CGPointZero inView:recognizer.view];\n }\n}\n\n- (void)selectNodeForTouch:(CGPoint)touchLocation {\n SKSpriteNode *touchedNode = (SKSpriteNode *)[self nodeAtPoint:touchLocation];\n\n if(![self.draggedNode isEqual:touchedNode]) {\n self.draggedNode = touchedNode;\n // self.draggedNode.physicsBody.affectedByGravity = NO;\n }\n}\n\n@end\n\nA:\n\nYou're setting the position of the node directly, this bypasses collision detection. ", "If you move fast, the next position can be on the other side of the wall (or close enough so that physics will resolve the collision by moving the dragged node outside and above the wall). ", "\nEnabling usesPreciseCollisionDetection on the dynamic body may improve the situation but may not entirely prevent it. ", "Actually it may not make any difference due to setting the node position directly instead of moving the body using force/impulse.", "\nTo fix this behavior you can't rely on contact events. ", "Instead use bodyAlongRayStart:end: to determine if there's a blocking body between the node's current and the next position. ", "Even so this will only work with your current setup, but couldn't prevent the ray successfully passing through small gaps in the wall where the dynamic body wouldn't be able to fit through.", "\n\n" ]

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[ "Q:\n\nHow can I return a button to its original color\n\ni have the following code, and I am trying to figure out how can I set the first button to white if I click it once again, same thing for the next button.", "\nSo,if i clicked it once it turns red, but if I click again, it turns white.", "\nany ideas.", "\n <!", "DOCTYPE html PUBLIC \"-//W3C//DTD XHTML 1.0 Transitional//EN\"\n \"http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd\">\n <html xmlns=\"http://www.w3.org/1999/xhtml\">\n <head>\n <title> color divs </title>\n <meta name=\"author\" content=\"Lee Middleton\" />\n <meta name=\"keywords\" content=\"CIS120/121/122\" />\n <meta name=\"description\" content=\"Template for x/html, CSS and JavaScript\" />\n <style type=\"text/css\">\n .container {\n border: 1px solid blue;\n border-radius: 10px;\n width: 100px;\n height: 50px;\n }\n </style>\n <script language=\"javascript\">\n function changeColor(whichOne)\n {\n var thatOne = eval(whichOne);\n var element = document.getElementById(whichOne);\n var color = \"ff\";\n var stringColor;\n if (whichOne == 1)\n {\n stringColor = \"#\" + color + \"0000\";\n else {\n alert('it was clicked') ;\n }\n }\n\n }\n else if (whichOne== 2)\n {\n stringColor = \"#0000\" + color;\n }\n element.style.backgroundColor = stringColor;\n }\n </script>\n\n <body>\n <div class='container' id='1' style='margin: 150px 0 0 75px; float: left;' onclick='changeColor(1);'></div>\n <div class='container' id='2' style='margin: 150px 0 0 175px; float: left;' onclick='changeColor(2);'></div>\n <div class='container' id='3' style='margin: 150px 0 0 220px; float: left;' onclick='changeColor(3);'></div>\n </body>\n </html>\n\nA:\n\nAs the other solution mentions you could store the previous color in a variable so you can reset it when necessary, but there is an easier way if you just want to return the element to its default colour.", "\nJust do:\nelement.style.backgroundColor = '';\n\nThis just unsets the background-color part of the style attribute, allowing for the color from the css to be used.", "\nSo to toggle between default and a colour you can just do this:\nelement.style.backgroundColor = element.style.backgroundColor ? '' : '#' ", "+ color;\n\n" ]

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[ "Big Kit\n\nWhatever height, horizontal outreach or capacity you are looking for, Rapid Access has the solution to meet your requirements. ", "Our dedicated team of industry specialists have industry leading experience in advising you when it comes to hiring large equipment and the attachments to support it.", "\n\nOur “Big Kit” machines are available from depots throughout the Middle East to support your working at height needs." ]

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[ "Advances in the gas chromatographic determination of persistent organic pollutants in the aquatic environment.", "\nEnvironmental chemists have been challenged for over 30 years to analyse complex mixtures of halogenated organic pollutants like polychlorinated biphenyls (PCBs), polychlorinated alkanes (PCAs), polybrominated diphenyl ethers (PBDEs) and polychlorinated dibenzo-p-dioxins and polychlorinated furans (PCDD/Fs). ", "Gas chromatography (GC) often proved to be the method of choice because of its high resolution. ", "The recent developments in the field of comprehensive two-dimensional GC (GCxGC) show that this technique can provide much more information than conventional (single-column) GC. ", "Large volume injection (e.g. by programmed temperature vaporiser, or on-column injection) can be employed for the injection of tens of microliters of sample extract, in that way substantially improving the detection limits. ", "Electron-capture detection (ECD) is a sensitive detection method but unambiguous identification is not possible and misidentification easily occurs. ", "Mass spectrometric (MS) detection substantially improves the identification and the better the resolution (as with MS/MS, time-of-flight (TOF) MS and high-resolution (HR)MS), the lower the chances of misidentification are. ", "Unfortunately, this comes only with substantially higher investments and maintenance costs. ", "Co-extracted lipids, sulphur and other interferences can disturb the GC separation and detection leading to unreliable results. ", "Extraction, and more so, sample clean-up and fractionation, are crucial steps prior to the GC analysis of these pollutants. ", "Recent developments in sample extraction and clean-up show that selective pressurised liquid extraction (PLE) is an effective and efficient extraction and clean-up technique that enables processing of multiple samples in less than 1h. ", "Quality assurance tools such as interlaboratory studies and reference materials are very well established for PCDD/Fs and PCBs but the improvement of that infrastructure is needed for brominated flame retardants, PCAs and toxaphene." ]

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[ "Chewbacca and Buster Bluth. ", "Doctor Who and The Big Lebowski. ", "Joey Tribbiani, Hermione Granger, Bruce Wayne, and…a dancing baby tree.", "\n\nThe world’s largest characters have become the tiniest toys, and they’re making the biggest impact on the pop culture zeitgeist. ", "Funko’s Pop! ", "Vinyl line — a series of TV and film character figures recognizable by their squared-off heads and black eyes — has landed on a short list of must-have collectibles of the modern era, though it was a long road getting there.", "\n\n“We started off with five characters in the DC Comics line. ", "I brought them to Comic-Con in 2010, and got a horrible response from our diehard bobblehead fans,” the company’s CEO, Brian Mariotti, recalls. “", "But we were getting all these unique people in our booth — mainly women — that had never been in there before. ", "And I knew at that point we had a hit on our hands.”", "\n\nFive years later, Funko’s Pop! ", "collection boasts almost 3,000 unique pieces via licenses ranging from Star Wars and Shaun of the Dead to The Breakfast Club and Orphan Black. (", "Most recently, EW debuted the newest line: all six Friends, plus their pets.) ", "The collection of 3.75 inch figurines stands out in the marketplace thanks to a whimsical uniform style, a fair price point (most retail for around $10), and perhaps most vital, a “something for everyone” approach to its offerings of TV, movie, and video game characters from both massive phenomena and offbeat darlings.", "\n\n“You have to have the huge Walking Dead or Game of Thrones items that everyone wants, but you also need to do Firefly or Dodgeball. ", "There are fans looking specifically for that and we might be the only company offering something to have on their desk,” says vice president of creative Ben Butcher. “", "It’s very important that we’re not just going for the big home runs.” ", "Adds Mariotti: “If it doesn’t sell out, that’s okay. ", "If everything was bottom line-generated, our line would be boring and probably wouldn’t be half as successful.”", "\n\nThe company prides itself on employing a variety of fans from across the spectrum, and while some big-deal license negotiations happen in the conference rooms, other ideas are conceived on the floor. “", "There was a girl here who was a big fan of Supernatural,” recalls Butcher. “", "She pitched the idea, and [we tried it], and it really took off for us…everyone here is a fan at some level, and that passion drives whatever aspect of this company you’re doing.”", "\n\nThe resounding success of the Pop! ", "line — 40 million units in four years, leading to expanded lines like Mystery Minis and Marvel Collector Corps — has resulted in licensers now approaching them to get in on the action. “", "At first we had to call licensers and kind of beg them,” recalls Mariotti of the early days. “", "Now it’s kind of become a badge of honor to become a Pop!.”", "\n\nWhich is exactly how Hannibal showrunner Bryan Fuller felt when the company decided to immortalize him for a limited edition Comic-Con figurine. “", "There’s the initial perverse thrill of the mini-me and then the recollections of the violated action figures of most everyone’s youth,” Fuller says. “", "My friend Steve would do wonderfully horrible things to his sister’s Barbies. ", "As much as I love the idea of Fannibals creating behind the scenes dioramas with my Pop and the rest of the Hannibal Pops, I love more the idea of them doing wonderfully horrible things with little me.”", "\n\nImage zoom Funko\n\n“It was just our way of saying, ‘Hey man, we love what you do,” says Mariotti of creating the rare Pop for a real person versus a character. (", "During Comic-Con, Funko also released a quartet of Conan O’Brien Pops.) ", "The company is also considering Pops! ", "for fellow creative minds like American Horror Story’s Ryan Murphy and Game of Thrones‘ David Bennioff and Dan Weiss, though in limited amount. “", "We made a very small run [for Fuller]. ", "It will probably end up being one of the rarest Pops of all time.”", "\n\nThough there’s an even more rare Pop! ", "to be found somewhere within the recesses of Bad Robot. “", "We’ve done some very secret, no-one-knows type of things,” Mariotti says. “", "We’ve done a J.J. Abrams Pop! ", "for Kathleen Kennedy — they’re only one-offs, but somebody, somewhere has got a J.J. Abrams Pop!”", "\n\nBut choosing who gets made into a Pop! ", "is only the beginning. ", "The five-year trial-and-error process of fitting the characters into the uniform Pop! ", "style resulted in the development of an extensive library of exceptions that help tricky characters fit the mold, so to speak. ", "Consider Cookie Monster’s googly eyes, which couldn’t adopt the black-eye style without looking, well, terrifying. “", "The basic rule is, whatever we need to pull in to make this look like the character, we will,” says Butcher. ", "But once one exception is made, licensers feel that exceptions are then rules, which explains why Butcher feels the challenge of Pop!-ing new characters is only growing as the licenses expand and the characters become more complicated. “", "The most common pushback is to adjust the eyes or the mouth,” says Butcher, whose team submits, as a rule, just one design per character for the licensers’ approval. “", "Even if a licenser loves Pop!, ", "they may not know what their comfort zone is of their characters being brought into our world.”", "\n\nBut Funko’s work stands for itself, and it’s helped bring around some high-profile licensers like Friends, Seinfeld, and perhaps the biggest coup of all, the world of Harry Potter. “", "We were the first company that [Warner Bros.] allowed to do the characters stylized,” gushes Butcher. “", "They’re a licenser that wanted to do it but were really uncomfortable going stylized, and so we dipped our toe in the water. ", "Once they could hold one of these finished products in their hand, they got really excited, J.K. Rowling got excited, and so now we’re trying to dive in more and do a lot more variants and exclusives that you want to go hunt and find.” (", "The Potter roll-out will initially include the core seven — Harry, Ron, Hermione, Dumbledore, Snape, Hagrid, and Voldemort — with the second and third phases exploring other creatures and characters in the wizarding world.)", "\n\nThe power of persuasion all goes back to the form. “", "We’ve established a form that we believe will be around for a decade or two, much like action figures have been since the ‘50s and bobbleheads since the ‘30s,” says Mariotti. ", "Unlike similar variety toy fads like Beanie Babies, Mariotti maintains the key to Pop’s relevance is having no shortage of new content to channel into the potentially enduring template. “", "There are six Star War movies in 30 years, and suddenly there will be six new ones. ", "There’s just a proliferation of great context in TV, video games, and movies that really is going to keep Pop! ", "relevant for years to come.”", "\n\nAdditional reporting by James Hibberd." ]

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[ "A study of the influence on diabetes of free and conjugated bisphenol A concentrations in urine: Development of a simple microextraction procedure using gas chromatography-mass spectrometry.", "\nThe association between bisphenol A (BPA) exposure and adult health status is examined by measuring the urinary BPA concentration using a miniaturized technique based on dispersive liquid-liquid microextraction (DLLME) in combination with gas chromatography-mass spectrometry (GC-MS). ", "Both the free bioactive and the glucuronide conjugated forms of BPA were measured, the glucuronide form usually being predominant. ", "The main analogs of BPA, including bisphenol Z (BPZ), bisphenol F (BPF) and biphenol (BP) were also determined. ", "Several parameters affecting enzymatic hydrolysis, derivatization by in-situ acetylation and the DLLME stages were carefully optimized by means of multivariate designs. ", "DLLME parameters were 2mL urine, 1mL acetone and 100μL chloroform, and hydrolysis was performed using β-glucuronidase and sulfatase at pH 5. ", "No matrix effect was observed and quantification was carried out by aqueous calibration with a surrogate standard. ", "Detection limits were in the range 0.01-0.04ngmL(-1). ", "The intraday and interday precisions were lower than 11% in terms of relative standard deviation. ", "Satisfactory values for all compounds were obtained in recovery studies (92-117%) at two concentration levels. ", "Other bisphenols (BPF, BPZ and BP) were not detected in the urine samples, while BPA was the only bisphenol detected in the free form (creatinine adjusted) at concentration levels ranging from the detection limit to 15.9ngg(-1), and total BPA was detected at concentrations ranging from 0.46 to 24.5ngg(-1) levels. ", "A comparison of the BPA content for both groups of patients revealed that slightly higher mean values were obtained for both free BPA and total BPA for diabetic patients, than for non-diabetic patients. ", "However, a statistical comparison of the contents of BPA revealed that there were no significant differences. ", "The procedure was validated using a certified reference material." ]

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[ "32\n\n1735, printed by J.R. for J. Walthoe, J.J. and P. Knapton, A. Bettesworth and C. Hitch, R. Robinson, J. Pemberton [and 4 others in London]\n\nMicroform in English - The two and twentieth edition." ]

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[ "Despite incessant efforts to combat cancer over decades, breast cancer is still the second leading cause of death in women, remaining high with over 39 000 deaths in 2012 in the United States alone.^[@bib1]^ Conventional interventions, such as radiation or chemotherapy, may eliminate the bulk of the tumor but spare rare aggressive cancer cells that have an exceptional capacity to survive, self-renew, and advance the malignancy. ", "These residual tumor cells have recently been found to possess key stem-like properties and have thus been termed 'cancer stem cells (CSCs)\\'.^[@bib2],\\ [@bib3],\\ [@bib4],\\ [@bib5]^ Breast CSCs, characterized by expression of CD44^high^/CD24^−/low^ surface markers, are proposed to be largely responsible for cancer progression and metastasis.^[@bib3],[@bib6],[@bib7]^ These CD44^high^/CD24^−/low^ cells possess stem cell-like properties and tumor-initiating capacity. ", "Furthermore, these cells resist standard therapies^[@bib3],[@bib6],[@bib8],[@bib9]^ and can be converted from non-CSC cells under certain conditions.^[@bib10],[@bib11]^ Therefore, specific targeting of CSCs within a tumor will be imperative to prevent disease progression and recurrence.^[@bib5]^ However, the conditions and mechanisms underlying CSC formation remain poorly understood. ", "Although the majority of cancers arise from *de novo* oncogenic and epigenetic alterations, most tumors display signals of unremitting inflammatory activity,^[@bib12]^ which occurs even in the absence of infection or autoimmunity.^[@bib13]^\n\nToll-like receptors (TLRs) are a key family of microbial sensors in the host innate and adaptive immunity as well as in tissue repair and regeneration. ", "They are also involved in the inflammatory signaling triggered by endogenous macromolecules released by injured tissue.^[@bib14],[@bib15]^ Ten TLRs are encoded by the human genome. ", "TLRs detecting nucleic acids (TLR3, TLR7, TLR8, and TLR9) are localized in the endosomal compartment in nearly all cell types, while TLRs mainly detecting proteolipidic structures (TLR1, TLR2, TLR4, TLR5, TLR6, and TLR10) are exposed on the cell surface.^[@bib14],[@bib16]^ In cancer, TLRs have emerged as important participants in tumorigenesis. ", "TLR3, 4, 7, and 9 were overexpressed in 70, 72, 67, and 78% of patients with esophageal cancer.^[@bib17]^ The -196 to -174del/del genotype of TLR2 may increase the risk of gastric cancer,^[@bib18]^ and TLR4+896A\\>G polymorphism is a risk factor for non-cardia gastric carcinoma.^[@bib19]^ Functions of epithelial-expressed TLR2 and 5 in promoting epithelial cell survival, proliferation, migration,^[@bib20]^ and angiogenesis (TLR2 only)^[@bib21]^ may be usurped by tumor cells to facilitate progression and metastasis. ", "Although TLR3, 5, 7, 8, and 9 may achieve antitumor effects by converting immune tolerance into antitumor immunity,^[@bib14]^ considerable discrepancies have been reported. ", "For instance, high TLR3 expression in esophageal cancer cells was significantly associated with a higher probability of lymph-node metastasis and increased depth of invasion.^[@bib17]^ Elevated TLR3 expression in breast cancer was also associated with poor prognosis.^[@bib22],[@bib23]^\n\nSeveral clinical trials using TLR agonists for cancer treatment are currently in progress. ", "Among all anticancer immunotherapy agents, TLR agonists are classified as the ones with highest potential. ", "However, clinical outcomes are inconsistent and repeatedly disappointing.^[@bib24]^ Specifically, high expectations were placed on TLR3 agonists for their ability to boost host immune systems to fight diseases. ", "TLR3 is located in intracellular endosomes for the recognition of double-stranded RNA (dsRNA) and polyinosinic-polycytidylic acid (poly(I:C), a synthetic analog of dsRNA).^[@bib25]^ In addition to upregulating immune response, a broader range of functions of TLR3 have been revealed recently, especially in stem cells. ", "For instances, activation of TLR3 was found to amplify mesenchymal stem cell trophic factors and enhance therapeutic potency.^[@bib26]^ Recently, Lee *et al.*^[@bib27]^ also showed that TLR3 stimulation caused rapid and global changes in the expression of epigenetic modifiers to enhance chromatin remodeling and nuclear reprogramming when converting adult cells to induced pluripotent stem cells. ", "Nevertheless, the role of TLR3 in cancer remains inconsistent, and its function in breast CSCs is unclear.", "\n\nHere, we demonstrate that TLR3 activation in breast cancer cells leads to a preferential enrichment of a subset of cells with CSC phenotypes *in vitro* and *in vivo*. ", "Conventional NF-*κ*B signaling is not fully responsible for the enhanced CSC properties. ", "Unexpectedly, *β*-catenin pathway is required for the promotion of CSC phenotypes in breast cancer cells following TLR3 activation. ", "Our results provide new tantalizing strategies to effective target breast and other CSCs with elevated TLR3 expression to prevent progression and relapse.", "\n\nResults\n=======\n\nTLR3 but not TLR5, 7, and 8 activation associates with breast CSC-like properties\n---------------------------------------------------------------------------------\n\nTo determine whether TLR3 stimulation links to CSC phenotypes, we activated TLR3 pathway in inflammatory breast cancer cell line SUM190 using poly(I:C), a specific TLR3 ligand.^[@bib25]^ In contrast to control cells showing an adherent monolayer, exposure of Sum190 cells to poly(I:C) for 4 days resulted in the formation of adherent spherical clusters with an increase in cluster size after continuous culture in the presence of poly(I:C). ", "Notably, the majority of spherical clusters consisted of live cells ([Figure 1a](#fig1){ref-type=\"fig\"}). ", "These observations suggest that SUM190 cells can form a mammosphere-like structure (a property associated with CSCs) to survive and proliferate in response to poly(I:C) stimulation. ", "Coincidently, the transcripts of *CD44* and *ALDH1* (two markers commonly used in characterization of breast CSCs) increased significantly after activation of TLR3. ", "Furthermore, mRNA and protein levels of transcriptional factors associated with CSC properties^[@bib28]^ (e.g., Nanog, Oct4, Sox2, Klf4, and c-Myc) increased markedly ([Figures 1b and c](#fig1){ref-type=\"fig\"}). ", "As such, these results point to a possible link between TLR3 activation and CSC phenotypes in SUM190 cells.", "\n\nTo determine whether the aforementioned observations are specific for TLR3, we examined TLR5, 7, and 8, which have also been implicated in enhancing antitumor immunity.^[@bib14]^ Although SUM190 cells expressed TLR5, 7, and 8, the mammosphere-like structure and stem-like gene expression signatures were observed only after treatment with TLR3 ligand poly(I:C), but not with TLR5 ligand Flagenin or TLR7/8 ligand R848 (data not shown). ", "This suggests that TLR3 activation uniquely associates with CSC-like properties in breast cancer cell SUM190.", "\n\nTo exclude the possibility that TLR3 activation is breast cancer cell-type specific, we also examined the breast ductal carcinoma cell line BT-483, adenocarcinoma cell line Cama-1 and triple-negative inflammatory breast cancer cell line SUM149. ", "Triple-negative breast cancer and inflammatory breast cancer represent two of the most aggressive forms of human breast cancer, as characterized by their unique molecular profiles, aggressive behavior, and distinctive metastasis patterns.^[@bib29],[@bib30]^ Significantly, we found that TLR3 expression was also present in SUM149, BT-483, and Cama-1 cells. ", "Quantitative PCR (qPCR) results showed that poly(I:C)-treated cells exhibited a similar profile of gene expression upregulation associated with stem-cell properties and cancer metastatic potential. ", "Specifically, CD44 and ALDH1, two important breast CSC markers, increased 2- to 17-fold in all cell lines examined ([Figure 1d](#fig1){ref-type=\"fig\"}), suggesting that TLR3 activation, but not TLR5, 7, and 8, associates with CSC properties in different subtypes of breast cancer cells.", "\n\nTLR3 activation promotes CSC phenotypes *in vitro*\n--------------------------------------------------\n\nHuman breast CSCs are commonly characterized *in vitro* by expression of CD44^high^/CD24^−/low^ surface markers,^[@bib3],[@bib7],[@bib11]^ tumorigenic capacity and drug resistance.^[@bib6],[@bib8],[@bib9]^ Using flow cytometry (FACS), we first examine the changes in CD44^high^/CD24^−/low^ sub-population after poly(I:C) stimulation. ", "Although non-stimulated SUM190 and SUM149 possess an inherently higher percentage of CD44^high^/CD24^−/low^ sub-population, poly(I:C) treatment led to a further upregulation of this subset by \\~3- to 5-fold ([Figure 2a](#fig2){ref-type=\"fig\"}). ", "Similarly, a 6- and 16-fold boost of CD44^high^/CD24^−/low^ fraction was observed in poly(I:C)-treated BT483 and Cama-1 cell lines, respectively ([Figure 2a](#fig2){ref-type=\"fig\"}).", "\n\nTo test whether tumorigenic potential is also affected by TLR3 activation, we performed soft-agar colony-forming assays and scored the numbers of colony (\\>100*μ*m). ", "Anchorage-independent cell growth measured in the soft agar is the gold standard for cellular testing of potential therapeutic agents in oncology since the method was established by Hamburger and Salmon.^[@bib31]^ This assay reflects the presence of self-renewing, gland-reconstituting stem cells within the population.^[@bib32]^ As anticipated, we found that poly(I:C) treatment resulted in a \\>3-fold increase in colony-forming capacity than controls for SUM190 cells. ", "A similar result was also obtained using SUM149, BT483, and Cama-1 cell lines with poly(I:C) treatment ([Figure 2b](#fig2){ref-type=\"fig\"} ).", "\n\nWe further examined whether poly(I:C)-treated breast cancer cells became more resistant to chemotherapeutic drugs, another known CSC property.^[@bib8],[@bib9]^ As expected, poly(I:C)-treated cells were more resistant than controls to two commonly used chemotherapeutic drugs, paclitaxel and doxorubicin ([Figure 2c](#fig2){ref-type=\"fig\"}). ", "Collectively, the significant increases in CD44^high^/CD24^−/low^ sub-population, clonogenic capacity, and drug resistance after poly(I:C) treatment demonstrate that TLR3 activation enhances breast CSC phenotypes *in vitro*.", "\n\nWe also observed that poly(I:C) promoted the growth of tumor cell aggregates and mammospheres (the methods used to enrich for cells with tumorigenic potential, [Supplementary Figures S1 and S2](#sup1){ref-type=\"supplementary-material\"}). ", "Moreover, poly(I:C) treatment significantly upregulated the expression of CSC markers in both fractionated CSC (CD44^high^/CD24^−/low^) and non-CSC (CD44^−/low^/CD24^high^) sub-populations ([Supplementary Figure S3](#sup1){ref-type=\"supplementary-material\"}). ", "It suggests that an increased pool of CSCs associates with the proliferation of CSCs along with the induction of CSC phenotypes from non-CSCs after TLR3 activation.", "\n\nTLR3 activation enriches breast CSCs *in vivo*.", "\n-----------------------------------------------\n\nTo investigate whether TLR3 activation promotes induction of breast CSCs *in vivo*, we treated tumor-bearing mice with poly(I:C), and then analyzed the excised tumors for CSC-associated properties. ", "The same number of SUM190 and SUM149 human breast cancer cells was implanted in the mammary fat pads of athymic nude mice. ", "When tumors reached a mean diameter of 4 mm, control mice were intraperitoneally (i.p.) ", "injected with vehicle while test mice with poly(I:C) (250 *μ*g every other day). ", "As shown in [Figures 3a and b](#fig3){ref-type=\"fig\"}, a decrease in tumor size was observed in poly(I:C)-treated mice in comparison with control group, indicating an inhibition in tumor growth. ", "This result was consistent with a previous report that TLR3 agonists repress but not eradicate the established primary tumors.^[@bib33]^ However, CD44^high^/CD24^−/low^ sub-population increased significantly by 2.2-fold in SUM190-transplanted mice and 2.3-fold in SUM149-transplanted mice ([Figure 3c](#fig3){ref-type=\"fig\"}) after \\~30 days of poly(I:C) administration. ", "Consistently, absolute numbers of CD44^high^/CD24^−/low^ sub-population increased by 2.1-fold in SUM190-transplanted mice receiving poly(I:C) injection ([Figure 3d](#fig3){ref-type=\"fig\"}), demonstrating that TLR3 activation retards tumor growth but enriches for breast CSCs.", "\n\nTo determine whether the tumors containing a larger fraction of CD44^high^/CD24^−/low^ sub-population induced by poly(I:C) administration possess greater tumor-initiating potential, we performed secondary transplantation. ", "We serially diluted tumor cells containing various percentage of CD44^high^/CD24^−/low^ populations isolated from primary tumors and subsequently transplanted them into athymic nude mice without further poly(I:C) administration. ", "Notably, tumor cells isolated from poly(I:C)-treated mice containing \\<3-fold higher numbers of CD44^high^/CD24^−/low^ cells exhibited a greater than 100-fold tumor-initiating capacity than control ([Figure 3d](#fig3){ref-type=\"fig\"}; [Supplementary Figure S4](#sup1){ref-type=\"supplementary-material\"}), suggesting a strong tumorigenic potential after poly(I:C) treatment.", "\n\nWe next tested expression level of several 'stemness\\' genes in primary and secondary tumors. ", "Primary tumors from poly(I:C)-treated mice bearing either SUM190 or SUM149 showed higher levels of CD44, Sox2, and Nanog expression compared with vehicle controls ([Figure 3e](#fig3){ref-type=\"fig\"}). ", "However, without further administration (i.e., a stimulation-withdraw) of poly(I:C), secondary tumors did not show an upregulation in those 'stemness\\' genes ([Figure 3e](#fig3){ref-type=\"fig\"}), indicative of a simulative effect of TLR3 activation on the induction and maintenance of breast CSC properties. ", "Collectively, the results from FACS, secondary transplantation, and gene expression profiling demonstrate that TLR3 activation significantly enhances tumor-initiating capacity and promotes CSC phenotypes *in vivo*.", "\n\nNF-*κ*B signal is not exclusively responsible for TLR3 activation-enhanced CSC phenotypes\n-----------------------------------------------------------------------------------------\n\nIt is well known that cellular responses to TLR3 activation are principally regulated by NF-*κ*B signal pathway.^[@bib14]^ As NF-*κ*B activates prosurvival pathways, we originally hypothesized that NF-*κ*B signaling was the key contributor to TLR3 activation-induced CSC phenotypes. ", "We indeed observed a significant increase in nuclear translocation of NF-*κ*B p65 in all four breast cancer cell lines after poly(I:C) treatment ([Figure 4a](#fig4){ref-type=\"fig\"}). ", "The increased NF-*κ*B activities after TLR3 agonist stimulation were further confirmed by qPCR analysis, showing a higher expression in NF-*κ*B-dependent genes IL8 and I*κ*B*α* ([Figure 4b](#fig4){ref-type=\"fig\"}).", "\n\nTo confirm the role of NF-*κ*B in TLR3 activation-enhanced CSC phenotypes, we blocked NF-*κ*B pathway with a specific inhibitor BAY11-7082. ", "Unexpectedly, NF-*κ*B inhibition was incapable of effectively blocking the increase in gene expression of CD44, c-Myc, Sox2, and Klf4 that associate with CSC properties ([Figure 4c](#fig4){ref-type=\"fig\"}). ", "FACS analysis also showed an ineffective repression on the elevated CD44^high^/CD24^−/low^ sub-population induced by TLR3 activation after NF-*κ*B inhibition with BAY11-7082 ([Figure 4d](#fig4){ref-type=\"fig\"}). ", "We further employed NF-*κ*B siRNA knockdown and obtained similar results ([Figure 5f](#fig5){ref-type=\"fig\"}). ", "Collectively, these data demonstrate that the NF-*κ*B signaling pathway is not exclusively responsible for TLR3 activation-enhanced CSC phenotypes in breast cancer cells.", "\n\nCombination of *β*-catenin and NF-*κ*B pathways is responsible for TLR3 activation-enhanced CSC phenotypes\n----------------------------------------------------------------------------------------------------------\n\nTo determine which signaling pathways co-contribute to the increased CSC phenotypes induced by TLR3 activation, we examined a number of pathways and finally focused on Wnt/*β*-catenin. *", "β*-Catenin has been implicated in different stages of mammary gland development and mammary oncogenesis.^[@bib34]^ Cancer cells with increased *β*-catenin expression have been shown to exhibit greater metastatic potential.^[@bib35]^ However, it is unknown whether *β*-catenin signaling is involved in TLR stimulation-enhanced CSC phenotypes. ", "Here, we observed an upregulation of *β*-catenin targeted genes, Axin2 and cyclinD1, upon poly(I:C) treatment ([Figure 5a](#fig5){ref-type=\"fig\"}), indicative of the activation of Wnt/*β*-catenin signaling pathway. ", "Western blotting also showed an increase in nuclear translocation of active *β*-catenin after poly(I:C) treatment ([Figure 5b](#fig5){ref-type=\"fig\"}). ", "Specifically, using a *β*-catenin/TCF/LEF-dependent enhanced green-fluorescent protein (eGFP) reporter, we found that TCF-eGFP reporter activity was significantly increased in the lentivirus-transduced SUM190 cells after poly(I:C) treatment ([Supplementary Figure S5](#sup1){ref-type=\"supplementary-material\"}). ", "In combination with aforementioned observations, it suggests that TLR3 stimulation is capable of activating not only NF-*κ*B but also Wnt/*β*-catenin signaling in breast cancer cells.", "\n\nTo further determine whether *β*-catenin signal is involved in TLR3-induced CSC phenotypes, we used a *β*-catenin pathway inhibitor BC21. ", "As shown in [Figure 5c](#fig5){ref-type=\"fig\"}, BC21 only partially inhibited poly(I:C)-induced expressions of CSC-associated genes CD44, ALDH1, c-Myc, and Oct4. ", "Strikingly, simultaneously inhibiting both NF-*κ*B and *β*-catenin pathways robustly suppressed TLR3 activation-induced upregulation of CSC-associated genes and proteins ([Figures 5c and d](#fig5){ref-type=\"fig\"}). ", "These observations were further confirmed by double knockdown of both NF-*κ*B p65 and *β*-catenin pathways since the expression levels of CD44 and c-Myc proteins were effectively suppressed ([Figure 5e](#fig5){ref-type=\"fig\"}, western blot). ", "Moreover, double knockdown of NF-*κ*B p65 and *β*-catenin, but neither alone, led to an almost complete abolition of the enriched CD44^high^/CD24^−/low^ sub-population induced by poly(I:C) stimulation ([Figure 5f](#fig5){ref-type=\"fig\"}, FACS). ", "Together, these data demonstrate that *β*-catenin and NF-*κ*B signals co-contribute to TLR3 activation-induced CSC phenotypes.", "\n\nCardamonin is capable of blocking both *β*-catenin and NF-*κ*B pathways and abrogating TLR3 activation-enhanced CSC phenotypes *in vitro*\n-----------------------------------------------------------------------------------------------------------------------------------------\n\nTo identify compounds that can block breast CSC phenotypes promoted by TLR3 activation with clinical application potential, we screened a series of small molecular inhibitors targeting *β*-catenin and/or NF-*κ*B signals, and finally focused on cardamonin ([Figure 6a](#fig6){ref-type=\"fig\"}). ", "Cardamonin is one of the main ingredients from the seeds of Alpinia katsumadai Hayata and belongs to chalcone with antibacterial and anti-inflammatory effect. ", "Significantly, cardamonin was capable of suppressing poly(I:C)-induced formation of mammosphere-like structure ([Figure 6b](#fig6){ref-type=\"fig\"}) and inhibiting nuclear translocation of both NF-*κ*B and active *β*-catenin ([Figure 6c](#fig6){ref-type=\"fig\"}). ", "Western blot analysis of these tumor cells showed that cardamonin inhibited the expression of Oct4, c-Myc, and CD44 induced by poly(I:C) stimulation ([Figure 6e](#fig6){ref-type=\"fig\"}). ", "Furthermore, cardamonin almost completely abrogated the enriched CD44^high^/CD24^−/low^ CSC sub-population induced by poly(I:C) treatment in all four cell lines examined, including SUM190, SUM149, Cama-1, and BT483 ([Figure 6d](#fig6){ref-type=\"fig\"}). ", "Consistently, cardamonin treatment also significantly suppressed *in vitro* tumorsphere-forming capacity ([Figure 6f](#fig6){ref-type=\"fig\"}). ", "Together, the above data demonstrate that cardamonin abrogates TLR3 stimulation-induced CSCs *via* inhibiting both *β*-catenin and NF-*κ*B pathways.", "\n\nCardamonin abolishes tumor-initiating potential induced by poly(I:C) *in vivo*\n------------------------------------------------------------------------------\n\nTo determine whether cardamonin is capable of repressing poly(I:C)-enhanced CSCs *in vivo*, we implanted SUM190 cells in the mammary fat pads of athymic nude mice followed by drug treatment. ", "When the tumor reached a mean diameter of 4 mm, mice were randomized into six groups and injected i.p. ", "with poly(I:C) and/or vehicle plus 10 or 30 mg/kg of cardamonin every other day ([Figure 7a](#fig7){ref-type=\"fig\"}). ", "Tumor volumes were measured every other day after drug treatment. ", "On day 32, animals were killed and tumors were harvested and weighed. ", "An increase in the CSC pool was observed in the mice treated with poly(I:C) alone though tumor weights were lower than vehicle control ([Figures 7b--d](#fig7){ref-type=\"fig\"}). ", "Importantly, 30 mg/kg of cardamonin treatment almost completely abolished poly(I:C) stimulation-induced CSCs in mouse xenografts ([Figures 7c and d](#fig7){ref-type=\"fig\"}). ", "Given no substantial side effects observed after cardamonin injection every other day for 20 days, it is possible to further increase injection frequency and/or dosages to optimize treatment efficacy. ", "Collectively, cardamonin abrogates poly(I:C)-induced CSCs not only *in vitro* ([Figure 6](#fig6){ref-type=\"fig\"}) but also *in vivo* ([Figure 7](#fig7){ref-type=\"fig\"}) and can be considered as a potential drug candidate to prevent the TLR3 activation-enriched breast CSCs.", "\n\nDiscussion\n==========\n\nRecurrence of breast cancer remains a significant clinical challenge. ", "Inconsistent clinical trials using TLRs to boost immune systems against cancer is largely due to our incompletely understanding of TLRs\\' roles in CSCs. ", "In this study, we demonstrate that TLR3 activation leads to breast CSC enrichment *in vitro* and *in vivo*. ", "It is intriguing that a combination of NF-*κ*B and *β*-catenin signals, but neither alone, is fully responsible for poly(I:C)-enhanced CSC phenotypes. ", "Cardamonin, a small molecule identified in this study, is capable of blocking both NF-*κ*B and *β*-catenin pathways to effectively abolish TLR3 activation-enriched CSCs *in vitro* and *in vivo* ([Supplementary Figure S6](#sup1){ref-type=\"supplementary-material\"}).", "\n\nAn unappreciated role of TLR3 in enriching breast CSCs\n------------------------------------------------------\n\nThe importance of TLR3 signaling in CSC phenotypes has not been established until now. ", "In early efforts, several studies found that activation of TLR3 signal displayed anticancer properties, possibly mediated by IFN*γ* production and/or TLR3-induced apoptosis.^[@bib33],[@bib36]^ Others reported that elevated TLR3 expression in breast cancer patients was associated with poor prognosis.^[@bib22]^ These findings suggest that TLR3 has more complicated biological functions than previously understood. ", "In this study, we found that TLR3 activation did induce certain tumor cell death while concurrently potentiating CSC phenotypes and tumor-initiating capacity in breast cancer cells. ", "Using qPCR analysis and soft-agar colony-forming assays, we showed a significant upregulation of various stem cell markers and an increase in tumor propagating properties *in vitro* after treatment with TLR3 agonist poly (I:C). ", "Our secondary implantation model further revealed that TLR3 agonist markedly promoted tumor growth in nude mice. ", "Hence, despite an initial growth retardation after TLR3 activation, the acquisition of CSC phenotypes in the remaining tumor cells could engender a stronger and more robust 'second wave\\' of tumor growth (greater than 100-fold, [Figure 3d](#fig3){ref-type=\"fig\"}). ", "On the basis of our results that TLR3 activation hinders tumor growth but enriches breast CSCs, the examination of tumor size (or total number of cancer cells) instead of CSC sub-populations could lead to a different conclusion.", "\n\n*β*-Catenin signaling is required for TLR3 activation-enhanced breast CSC phenotypes\n------------------------------------------------------------------------------------\n\nA direct connection among TLR3, *β*-catenin signaling, and breast CSCs was previously lacking. ", "TLR3 signaling is known to culminate in activation of transcriptional factor NF-*κ*B, which controls the expression of a battery of pro-inflammatory genes. ", "NF-*κ*B has also been considered to be a key contributor in promoting tumor progression, as it is found to be frequently overactivated in human breast cancers.^[@bib37],[@bib38]^ However, a moderate suppression of breast CSC phenotypes following blockage of TLR3-mediated NF-*κ*B activation, as shown in our results, suggests other pathways also take place.", "\n\nHere, we provide the first evidence that *β*-catenin, unexpectedly, is essential for TLR3 activation-enhanced breast CSC phenotypes. ", "Significantly, after knockdown of both NF-*κ*B and *β*-catenin, the enrichment in CSC population was almost entirely lost. ", "This emphasizes that co-activation of both NF-*κ*B and *β*-catenin, but neither alone, following TLR3 stimulation leads to the acquisition of a CSC phenotype. ", "Given that poor clinical prognosis was associated with elevated TLR3 expression in breast cancer,^[@bib22]^ it is possible that tumor cells with high levels of TLR3 expression and activation of NF-*κ*B and Wnt/*β*-catenin pathways are more resistant to conventional therapies and easy to relapse. ", "Hence, understanding how CSCs are regulated by TLR3 stimulation and *β*-catenin activation is crucial if they are to be targeted for therapy.", "\n\nTLR3 agonists and CSCs\n----------------------\n\nA triad of TLR3 stimulation, NF-*κ*B and *β*-catenin activities in promoting CSC phenotypes indicates a combinational use of TLR3 agonists with NF-*κ*B and *β*-catenin inhibitors, but neither alone, may help to improve clinic outcomes and efficacy of TLR3 agonists in patients with breast cancer. ", "In an effort to introduce new approaches to target CSCs, we screened a number of small molecules, and identified cardamonin, a chalcone isolated from the fruits of a local plant. ", "Cardamonin treatment effectively blocking TLR3 activation-induced CSCs *in vitro* and in a mouse xenograft model suggests its strong potential and high specificity of targeting breast CSCs. ", "In particular, since elevated TLR3 expression was also highly expressed in other cancer patients and reversely correlated with poor prognosis, it is possible that inhibition of tumor TLR3 pathways may facilitate cancer treatment. ", "We believe that the findings presented here broaden our understandings of the roles of TLR3, *β*-catenin and NF-*κ*B in CSC biology, and also have potential clinical implications in terms of preventing induction of CSC phenotypes and targeting cancer stem-like cells under inflammatory conditions and endogenous stimuli of damaged cellular components.", "\n\nMaterials and Methods\n=====================\n\nCell culture and reagents\n-------------------------\n\nSUM190 and SUM149 were obtained from Asterand (Detroit, MI, USA) and cultured in Hams F-12 media (Mediatech, Manassas, VA, USA) containing 5 *μ*g/ml insulin, 1 *μ*g/ml hydrocortisone, antibiotics (penicillin/streptomycin), and 5% (SUM149) or 2% (SUM190) of fetal bovine serum (FBS) (HyClone, Logan, UT, USA). ", "Medium for SUM190 cells was further supplemented with 5 mM ethanolamine, 10 mM HEPES, 5 *μ*g/ml transferrin, 6.6 ng/ml 3,3\\',5-triiodo-[L]{.smallcaps}-thyronine sodium salt, 8.7 ng/ml sodium selenite, and 1 mg/ml bovine serum albumin (BSA). ", "Cells were cultured at 37 °C in a 5% CO~2~ incubator. ", "Breast cancer cell lines BT483 and Cama-1 were purchased from the American Type Culture Collection (Manassas, VA, USA) and maintained in DMEM-F12 (1:1) supplemented with 10% FBS. ", "Poly(I:C) was obtained from InvivoGen (San Diego, CA, USA). ", "Doxorubicin hydrochloride, 5-Fluorouracil, Paclitaxel, Insulin, Hydrocortisone, HEPES, and BSA were purchased from Sigma-Aldrich (St. Louis, MO, USA). ", "Cardamonin and Bay 11-7821 were purchased from TOCRIS Bioscience (Ellisville, MO, USA).", "\n\nTransfection, transduction, and *β*-catenin/TCF-eGFP reporter assays\n--------------------------------------------------------------------\n\nThe *β*-catenin/TCF/LEF-dependent reporter plasmid (7 × Tcf-eGFP/SV40-PuroR, 7TGP) was provided by Dr. Nusse *via* Addgene.^[@bib39]^ Lentiviral production was carried out as described previously.^[@bib40]^ Briefly, ten 10-cm dishes were seeded with 6 × 10^6^ cells per dish overnight before transfection. ", "For two dishes, 8 *μ*g of the lentiviral vector, 5.4 *μ*g of the psPax2 envelope plasmid, 3.6 *μ*g of the packaging plasmid (pMD2.G) were used. ", "The medium was replaced overnight, and lentiviral supernatant was harvested after 48 hours, filtered through a 0.45-*μ*m PES filter, and concentrated with Lenti-X concentrator (Clontech, Mountain View, CA, USA). ", "For viral infection, once SUM190 cells in 6-well plate reached 40--50% confluence, 1 ml of concentrated lentiviral supernatant and 8 *μ*g/ml of polybrene were added for 24 h. The infected cells containing the reporter TCF-eGFP cassette were selected with puromycin. ", "The TCF-eGFP expression levels after poly(I:C) treatment for 6, 24, and 48 h were determined by FACS.", "\n\nXenograft tumor growth\n----------------------\n\nAll mouse experimentation was conducted in accordance with standard operating procedures approved by the Animal Care Committee at the University of Ottawa. ", "Athymic nude mice (6 weeks old, female, 20--22 g body weight) were obtained from Charles River Laboratories (Saint-Constant, QC, Canada). ", "To establish breast cancer xenografts in nude mice, SUM190 or SUM149 cells were mixed with Matrigel and injected under aseptic conditions into mammary fat pads of nude mice (*n*=3--8 for each group, 1 × 10^6^ cells per fat pad). ", "The tumor was monitored and evaluated every 2--3 days with calipers. ", "Tumors were measured in two dimensions, and volume was calculated according to the formula: *V*=0.5 × (length) × (width).^[@bib2]^ When tumors reached a mean diameter of 4 mm, tumor-bearing mice were randomly assigned to six treatment groups: (1) vehicle (control), (2) poly(I:C) (250 *μ*g), (3) cardamonin (10 mg/kg), (4) cardamonin (10 mg/kg) plus 250 *μ*g of poly(I:C), (5) cardamonin (30 mg/kg), and (6) cardamonin (30 mg/kg) plus 250 *μ*g of poly(I:C). ", "Mice were injected i.p. ", "with the drugs every other day. ", "At the end of drug treatment, mice were humanely euthanized, and tumors were collected, weighed, disaggregated, and further analyzed by FACS and qPCR.", "\n\nSecondary transplantation of nude mouse model\n---------------------------------------------\n\nTumor tissues were dissociated mechanically and enzymatically to obtain a single-cell suspension. ", "Tumors were minced by scalpel and incubated in Hams F-12 (Invitrogen, Carlsbad, CA, USA) containing collagenase/hyaluronidase (STEMCELL Technologies, Vancouver, BC, Canada) at 37 °C for 60 min. ", "The tissues were further dissociated by pipette trituration and then passed through a 40-*μ*m nylon mesh to produce a single-cell suspension. ", "Two groups of mice were implanted with tumor cells. ", "Each mammary fat pad of athymic nude mouse was inoculated with 1 000 000, 100 000, 10 000, 1000, or 500 tumor cells harvested from mice that had been injected i.p. ", "with vehicle or poly(I:C) after the first tumor cell transplantation. ", "Tumor size was measured every other day.", "\n\nFACS analysis\n-------------\n\nCancer cells dissociated from transplanted tumor tissues or from culture plates were counted and resuspended in 100 *μ*l of HBSS containing 2% heat-inactivated FBS (HIFS) and 10^5^ cells. ", "Five microliters of mouse IgG solution (1 mg/ml) was added and incubated on ice for 10 min. ", "According to the manufacturer\\'s recommendation, appropriate antibodies were added and incubated for 30 min on ice. ", "Then, cells were washed twice with HIFS and resuspended in 0.2 ml of HIFS that contained 7-aminoactinomycin D (7-AAD, 1 *μ*g/ml final concentration). ", "Antibodies used were anti-CD44 (APC) and anti-CD24 (PE), which were purchased from BD Pharmingen (San Diego, CA, USA). ", "Dead cells were eliminated by using viability dye 7-AAD. ", "FACS was performed on a Cyan-ADP 9 (Beckman Coulter, Brea, CA, USA).", "\n\nFractionation of CSC and non-CSC sub-populations from breast cancer cells\n-------------------------------------------------------------------------\n\nTo separate CSCs from non-CSCs (SUM190 and Cama-1 cancer cells), single-cell suspensions were stained with CD44 antibody (APC-conjugated) and CD24 antibody (PE-conjugated) for 30 min, analyzed and sorted by FACS. ", "CSCs are defined by the minority CD44^high^/CD24^−/low^ population, whereas non-CSCs are defined by the majority CD44^−/low^/CD24^high^ population. ", "The CSCs and non-CSCs populations were sorted again to increase their purity (\\>99.2% in all cases). ", "CSCs were cultured in serum-free special medium. ", "Non-CSCs were cultured overnight in DMEM-F12 containing 2% FBS to allow cell attachment and survival. ", "The medium was changed to serum-free special medium next day to keep the experimental conditions as same as CSCs.", "\n\nSoft-agar colony formation\n--------------------------\n\nSUM190, SUM149, BT-483, and Cama-1 cells were cultured in the presence of poly(I:C) or reagents as indicated for 4 days. ", "A soft-agar assay was performed on 12-well plates with a base layer of 0.5% agarose gel containing DMEM. ", "To generate the cell layer, 5 × 10^3^ cells/well were suspended in 0.35% top agarose gel in DMEM/F12 medium containing B27 supplement, 20 ng/ml of EGF, and 20 ng/ml of basic FGF. ", "Plates were incubated at 37 °C in 5% CO~2~ for 17 days to allow colony formation, and cell viability was determined by staining with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT, 1 mg/ml). ", "Colonies of each cell line were counted (\\>100 *μ*m in diameter). ", "All experiments were performed in triplicate, and data are presented as means±S.D.\n\nMammosphere formation assay\n---------------------------\n\nSum190 were cultured in the presence or absence of 1 *μ*g/ml of poly(I:C) for 4 days, dissociated into single-cell suspension and reseeded on ultra-low attachment plates at a density of 1 × 10^3^ cells/well (12-well plate) in DMEM/F12 medium containing B27 supplement, 20 ng/ml of EGF, and 20 ng/ml of basic FGF. ", "Plates were incubated at 37 °C in 5% CO~2~ for 4 days to allow mammosphere formation followed by qPCR analysis.", "\n\nsiRNA knockdown\n---------------\n\nsiRNAs for NF-*κ*B p65 and *β*-catenin, and control scrambled siRNA were purchased from Thermo Scientific Dharmacon (Thermo Scientific, Rockford, IL, USA) as SMARTpools. ", "For siRNA transfections, cells were transiently transfected with these oligos using Lipofectamine RNAiMAX reagent (Invitrogen) according to the manufacturer\\'s instructions. ", "Transfection efficiency was assessed using qPCR and western blot. ", "One *μ*g/ml of poly(I:C) was added on the second day after siRNA transfection. ", "After transfection for 72 h, cells were trypsinized and subjected to qPCR and FACS assays.", "\n\nWestern blot analysis\n---------------------\n\nFor western blot analysis, cells were harvested and prepared using RIPA buffer (Sigma-Aldrich) and subcellular fractions taken using the NE-PER Nuclear Protein Extraction Kit (Thermo Scientific) containing protease inhibitor cocktails (Roche, Mannheim, Germany). ", "Protein concentration was determined using a Bio-Rad DC protein assay kit (Bio-Rad, Hercules, CA, USA). ", "Subsequently, 25--30 *μ*g of total protein was loaded onto an 8--12% SDS-polyacrylamide gel for electrophoresis and then transferred onto a PVDF membrane. ", "Protein was identified by incubating the membrane with primary antibodies, followed by horseradish peroxidase-conjugated secondary antibodies and an enhanced chemiluminescence solution (Pierce, Thermo Scientific). ", "Antibodies used in this study include: anti-CD44 (8E2) monoclonal antibody (5640), anti-Lamin A/C polyclonal antibody (2032), anti-c-Myc (D84C12) polyclonal antibody (5605), and anti-Sox2 (L1D6A2) monoclonal antibody (4900) from Cell Signaling (Danvers, MA, USA); anti-phospho-NF-*κ*B p65 pSer 536 monoclonal antibody (MA5-15160) from Thermo scientific; anti-Klf4 antibody (ab72543) from ABCAM (Toronto, ON, Canada); anti-Oct4 (N-19) polyclonal antibody (sc-8628) from Santa Cruz (Santa Cruz, CA, USA); anti-Nanog polyclonal antibody (AF1997) from R&D Systems (Minneapolis, MN, USA); anti-*β*-catenin (Clone 14, 610153) from BD (Mississauga, ON, Canada); anti-active *β*-catenin (anti-ABC, clone 8E7, 05665) from Millipore (MI, Billerica, MA, USA); anti-*α*-tubulin monoclonal antibody (T9026) from Sigma-Aldrich.", "\n\nQuantitative real-time PCR\n--------------------------\n\nTotal RNAs were extracted using RNeasy kit (Qiagen, Valencia, CA, USA) and real-time qPCR analysis was performed using Bio-Rad MyiQ (Bio-Rad) as previously described.^[@bib41]^ The conditions for qPCRs are one cycle at 95 °C for 20 s, followed by 40 cycles at 95 °C for 3 s and annealing at 60 °C for 30 s. Results were normalized to the housekeeping gene glyceraldehyde 3-phosphate dehydrogenase (GAPDH). ", "Relative expression level of genes from different groups was calculated with the ^2ΔΔ^CT method and compared with the expression level of the corresponding gene in control cells. ", "Specific primer sequences for individual genes are listed in [Supplementary Table S1](#sup1){ref-type=\"supplementary-material\"}.", "\n\nGrowth rates and cell viability assays\n--------------------------------------\n\nTo measure cell growth rates, 1000 cells per well were seeded onto 96-well plates in triplicates. ", "One day after seeding, compounds were added in five replicates per concentration for each cell line. ", "After 48 h, MTT reagent (tetrazolium) was added for 4 h and the reaction was stopped by removing MTT and adding. ", "DMSO (150 *μ*l) was added to each well to dissolve formazan crystals. ", "Absorbance was measured at 570 nm. ", "Cell viability was also assessed by a hemocytometer-based trypan blue dye exclusion.", "\n\nStatistical analyses\n--------------------\n\nData are expressed as mean±standard deviation (S.D.) unless specified elsewhere. ", "Statistical significance was determined using a Student\\'s *t*-test, or ANOVA wherever appropriate. ", "Results were considered as significant when *P*\\<0.05.", "\n\nWe apologize to all those colleagues whose important work could not be cited owing to space limitation. ", "This work is supported by operating grants from Canadian Breast Cancer Foundation-Ontario Region and the Canadian Institutes of Health Research MOP-111224 to LW.", "\n\nCSCs\n\n: cancer stem cells\n\nFBS\n\n: fetal bovine serum\n\nFACS\n\n: flow cytometry\n\n7-AAD\n\n: 7-aminoactinomycin D\n\nqPCR\n\n: quantitative PCR\n\nTLRs\n\n: toll-like receptors\n\nTLR3\n\n: toll-like receptor 3\n\ndsRNA\n\n: double-stranded RNA\n\npoly(I:C)\n\n: polyinosinic-polycytidylic acid\n\ni.p.", "\n\n: intraperitoneally\n\nMTT\n\n: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide\n\nGAPDH\n\n: glyceraldehyde 3-phosphate dehydrogenase\n\nCyto\n\n: cytoplasmic\n\nNu\n\n: nuclei\n\nCardamonin\n\n: 2,4-dihydroxy-6-methoxychalcone\n\neGFP\n\n: enhanced green-fluorescent protein\n\n[Supplementary Information](#sup1){ref-type=\"supplementary-material\"} accompanies this paper on Cell Death and Differentiation website (http://www.nature.com/cdd)\n\nEdited by JP Medema\n\nThe authors declare no conflict of interest.", "\n\nSupplementary Material {#sup1}\n======================\n\n###### \n\nClick here for additional data file.", "\n\n{#fig1}\n\n{#fig2}\n\n{#fig3}\n\n{#fig4}\n\n{#fig5}\n\n{#fig6}\n\n{#fig7}\n" ]

{ "pile_set_name": "PubMed Central" }

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[ "Color in Easter Eggs with Patterns Commercial Use Clip Art Set\n\nCompressed Zip File\nBe sure that you have an application to open this file type before downloading and/or purchasing.", "How to unzip files.", "\n5.6 MB | N/A pages\n\nPRODUCT DESCRIPTION\n\nEaster Clipart Set - 15 pieces of black and white / line art / blackline master clip art in a pack or bundle for your worksheets or educational resources. ", "All images or pictures are high resolution so you can have large illustrations of them and they'll still be clean and beautiful.", "\n\nImages are in PNG format with a transparent background (there aren't white areas around the outside edge) so they can be dropped into your documents easily, and layered with text or other images.", "\n\nPictures are licensed for any personal use and for commercial use in any educational product (or marketing materials for educational products). ", "Credit is appreciated but not required. ", "All images are copyright to me and are created by me and are not to be onsold or given away as clip art - if they're adding to your work that you are selling that's great, but you are not permitted to sell or distribute them as images or on their own. ", "You are not permitted to create derivative works from them and sell them as images, but you may change them for use in your personal or educational commercial products (worksheets, units, etc.).", "\n\nFor this item, the cost for one user (you) is $1.00.", "\nIf you plan to share this product with other teachers in your school, please add the number of additional users licenses that you need to purchase.", "\nEach additional license costs only $0.50." ]

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[ "Knapp drei Wochen vor Beginn der Rückrunde hat der 1. ", "FC Nürnberg seinen ersten Winterneuzugang unter Dach und Fach gebracht: Tschechiens U-21-Nationalspieler Ondrej Petrak unterzeichnete am Dienstag einen bis 2017 datierten Kontrakt bei den Franken. ", "Bei seinem Ex-Verein Slavia Prag bekleidete der 21-Jährige meist die Sechserposition, verteidigte zeitweise aber auch zentral in der Viererkette.", "\n\nDamit reagierte der abstiegsbedrohte FCN (Tabellen-17.) ", "auf seine missliche Lage in der laufenden Bundesligasaison: Nach 17 absolvierten Begegnungen warten die Nürnberger noch auf den ersten Dreier und stellen zudem die viertschlechteste Defensive. ", "Neuzugang Petrak soll der wackligen Abwehr also mehr Stabilität verleihen.", "\n\n\"Ondrej hat sich bei einem großen Traditionsverein wie Slavia Prag seit drei Jahren als unumstrittener Stammspieler durchgesetzt. ", "Es war auch immer der Wunsch von Trainer Gertjan Verbeek, einen Spieler zu verpflichten, der uns kurzfristig und über die Saison hinaus hilft, um unsere Ziele zu erreichen\", äußerte sich Sportvorstand Martin Bader auf der vereinseigenen Website zur Neuverpflichtung.", "\n\nDer Tscheche, der den Bundesligisten etwa eine Million Euro Ablöse kostete, sollte ursprünglich erst nach Saisonende zum Club stoßen. ", "Dass es schon im Winter geklappt hat, freut den 21-Jährigen umso mehr: \"Der Club genießt in meiner Heimat einen sehr guten Ruf. ", "Mein Ziel war es immer, in der Bundesliga zu spielen. ", "Deshalb habe ich mich sofort entschieden. ", "Mit dem 1. ", "FC Nürnberg will ich nun die gesteckten Ziele erreichen.\"", "\n\nPetrak feierte im Oktober 2010 als 18-Jähriger sein Liga-Debüt für Slavia Prag. ", "Seitdem bestritt er insgesamt 62 Ligaspiele für seinen Heimatklub und erzielte dabei zwei Treffer." ]

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[ "Photo shows former Director General Institute of Strategic Studies Dr Shireen M Mazari speaking at a public event in Islamabad.—Photo by ONLINE\n\nISLAMABAD: Central Vice President of Imran Khan’s Pakistan Tehreek-e-Insaf (PTI), Dr Shireen Mazari on Wednesday resigned from her basic party membership, citing differences “purely based on political issues”.", "\n\nIn messages posted on social media website Twitter, Mazari said: “I have given in my resignation from PTI. ", "I regretfully resign as people had real hopes with PTI.”", "\n\n“Not leaving PTI for any other party, purely based on political issues,” said Mazari in her messages. “", "Party program has been taken over by ‘big money’. ", "The membership drive was hijacked by ‘big money’. ", "This has compromised the party elections.”", "\n\nMazari was also incharge of Foreign Policy for the PTI. ", "The renowned analyst was served a notice by the party leadership after reportedly giving statements against PTI’s policies.", "\n\n“I haven’t left the ideology the party has departed from the ideology. ", "My resignation is not based on personal differences rather on policy and governance issues. ", "I am ready to serve PTI again if the party lives up to its principles,” added Mazari in further tweets clarifying her resignation.", "\n\n“Let me make it clear yes I was served a show cause notice & my resignation came after due deliberation. ", "I was NOT suspended from the party,” she added, clarifying her position." ]

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[ "\"I am a gardener from years past but never really \"knew\" what I was planting or growing. ", "I have really taken an interest in learning and knowing all I can. ", "I can't wait to learn more. ", "I've already receievd so much help.", "\nI am currently trying to grow from cuttings: Hens and chickens(echeveria elegans), kalanchoe, ctenanthe lubbersiana, philidandrum, purple velvet plant, begonias, and sanseveria.", "\nI love working outside in my garden as well as working on my inside plants. ", "Thank you in advance for any help. ", "Liz\"" ]

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[ "Amtrak's 60 Hz traction power system\n\nAmtrak operates a 60 Hz traction power system along the Northeast Corridor between New Haven, Connecticut and Boston, Massachusetts. ", "This system was built in the late 1990s and supplies locomotives with power from an overhead catenary system at 25 kV, 60 Hz. ", "The system is also commonly known as the Northend Electrification, in contrast to the Southend Electrification that runs from New York City to Washington DC.", "\n\nHistory\n\nIn 1992, Congress passed the Amtrak Authorization and Development Act requiring Amtrak to establish high-speed rail passenger service between New York City and Boston. ", "The goal was to reduce travel time in this corridor from 4.5 hours to less than 3 hours. ", "Revenue from this service was expected to play a critical role in helping Amtrak achieve operating self-sufficiency by 2003. ", "Before Amtrak could begin high-speed rail service, of rail line between New Haven and Boston had to be electrified. ", "Previously, electrified Metroliner service was available between Washington, D.C. and New Haven, Connecticut. ", "At New Haven, Amtrak had to switch to a diesel locomotive to complete the trip to Boston. ", "In addition to the higher operating speeds possible with electrified service, Amtrak also saves the time it spent on switching locomotives. ", "By the time the project was complete, Amtrak was expected to have spent over $600 million to electrify the line between New Haven and Boston. ", "Including extensive track and infrastructure improvements besides the electrification, the project cost $1.6 billion.", "\n\nIn December 1995, Amtrak awarded a $321 million contract to Balfour Beatty Construction, Inc./Mass. ", "Electric Construction (BBC/MEC) to verify and complete the Morrison-Knudsen design and build the electrification system. ", "The system was to be completed by June 1999; electrification system ground-breaking ceremony took place the following July.", "\n\nAmtrak's contractor faced a difficult working environment in the Boston Terminal Area because of the extensive work being undertaken for the Central Artery project, which involved over 500 employees in the South Boston Terminal area alone and entailed on-site storage of a large amount of heavy construction equipment and supplies. ", "The Central Artery project was ongoing before the electrification project started. ", "Another factor complicating electrification work in the Boston Terminal Area is the large volume of rail traffic. ", "Over 250 Massachusetts Bay Transportation Authority (MBTA) commuter trains and 20 Amtrak trains operate through the area daily. ", "As a result, taking track out of service to work on the electrification was sometimes difficult.", "\n\nElectrification work on the five movable bridges between Old Saybrook and Mystic in Connecticut was also a challenge, as each one required a unique electrification design and construction solution. ", "The bridges span busy waterways shared by pleasure craft, commercial carriers, and military traffic. ", "Unlike most movable highway bridges, these bridges are usually open, and are closed only to accommodate approaching train traffic.", "\n\nAfter several delays, service with electric locomotives between New Haven and Boston began on January 31, 2000. ", "Amtrak began operating its higher-speed Acela Express service on December 11, 2000.", "\n\nTypes of stations\n\nSystem architecture \n\nThe basic system unit is an elementary electrical section consisting of a segment of one or more parallel tracks, each with a contiguous contact (or catenary or trolley) wire for the locomotive pantograph and an electrically separate feed wire. ", "Elementary electrical sections are separated by section breaks where the contact and feeder wires can be interrupted with motor-operated air switches to isolate a section in the event of a fault or to permit maintenance.", "\n\nAn electrical section is a collection of elementary electrical sections, section breaks, air switches and paralleling stations between a substation and a switching station.", "\n\nAt each substation, utility-supplied single phase power is transformed and injected into the two electrical sections terminating at that substation. ", "There are eight electrical sections in the system, two for each substation. ", "The substations drive the contact and feed wires in a split phase arrangement so that each wire is at 25 kV with respect to the grounded running rails with 50 kV between them.", "\n\nAt periodically spaced paralleling stations within each electrical section the tracks' catenary wires are connected together to one side of an autotransformer and the feeder wires are connected together to the other side of the autotransformer. ", "The autotransformer center tap is connected to the grounded running rails that return the current from the locomotives. ", "The paralleling stations thus reduce voltage drops by feeding a locomotive from both directions along its contact wire and spreading the load across all the contact and feed wires of a multitrack system. ", "The split-phase arrangement also gains the increased efficiency of operating at 50 kV while the highest voltage with respect to ground remains only 25 kV. (The same split-phase method is used in North American homes to supply high power loads such as air conditioners with the efficiency of a 240 V supply while retaining the safety advantages of a 120 V supply.)", "\n\nSubstations \n\nThere are four substations between New Haven and Boston:\n Branford, CT\n New London, CT\n Warwick, RI\n Sharon, MA\nEach station contains two 115 kV (single phase) to 50 kV (single phase with center tap) transformers to convert the utility supplied transmission voltage to 50 kV traction voltage. ", "Output circuit breakers, and a capacitor based filter network are installed. ", "The filter banks suppress the high frequency (that is anything above 60 Hz) harmonics on the catenary lines generated by locomotives' solid-state traction motor inverters. ", "The filters also provide reactive power support and correct for power factor. ", "Amtrak's 60 Hz electrification distributes power using ±25 kV from ground via a center tap of the 115/50 kV transformers. ", "This system is also known as 2 × 25 kV.\n\nSwitching stations \nThree switching stations are the equivalent of distribution level substations, which transform higher voltage electricity to the 25 kV voltage, and are located along the line which separate the different electrical sections (power zones):\n Westbrook, CT\n Richmond, RI\n Norton, MA\nThe switching stations contain three autotransformers similar to the paralleling stations (which have one), and also have additional circuit breakers to allow segmentation of catenary and cross-connection between power zones.", "\n\nElectrical sections encompass both tracks between a substation and the adjacent switching stations. ", "Normally no power flows from one side of a switching station to the other side; it is like two adjacent paralleling stations which serve different electrical sections. ", "In the event that a substation is taken out of service, switching stations have additional circuit breakers which allow feeding an electrical section from the adjacent section.", "\n\nSince switching stations, like substations, normally separate electrical sections with different supply sources (and thus different phase or voltage), a neutral section always occupies the track between the two electrical sections.", "\n\nIn the event of a fault in one elementary electrical section, the switching station can 'back-feed' the far portion of the affected track from the non-affected track, which the supplying substation feeds the near end.", "\n\nParalleling stations \n\nEighteen paralleling stations are located at approximately six mile intervals along the line. ", "Each contains a single autotransformer (with the exception of Roxbury, which has two), automatic circuit breakers, motor-operated air switches, and a control shed. ", "The autotransformers are rated at 10 MVA, 1.2% impedance, two winding, 27.5 kV.\n\nEach paralleling station bus is connected to both north and south track catenary and feeder lines via automatic circuit breakers. ", "The autotransformer is connected to the bus bars by an additional circuit breaker. ", "The track breakers at the paralleling stations trip on sensing no-voltage. ", "Thus when a line fault causes the supplying substation breakers to trip, the paralleling stations also trip. ", "This action separates the two tracks from one another electrically and allows the substation to automatically restore one of the tracks (the non-faulted one). ", "After a variable time delay (to reduce simultaneous inrush current), over-voltage relays will re-shut the track circuit breakers on the non-faulted track.", "\n\nList of stations\n\nSee also \n 25 kV AC railway electrification\n Amtrak's 25 Hz Traction Power System operates along the southern portions of the Northeast Corridor\n SEPTA's 25 Hz Traction Power System\n List of railway electrification systems\n Overhead lines\n North–South Rail Link\n\nReferences\n\nNotes\n\nFurther reading\nEnvironmental Impact Statement: Volume 1, Volume 2, Volume 3\n .", "\n Audit Report of Amtrak's High Speed Rail Electrification Project, US Department of Transportation: Federal Railroad Administration, December 1999. ", "Retrieved 12/26/2010.", "\n Chance, E.E. \"System Compatibility of the HST\", Railroad Conference, 1997., ", "Proceedings of the 1997 IEEE/ASME Joint, pp 1–9, 1997. .", "\n EMF Monitoring on Amtrak's Northeast Corridor: Post-Electrification Measurements and Analysis, US Department of Transportation: Federal Railroad Administration, October 2006. ", "Retrieved 12/26/2010.", "\n Natarajan, R.; Imece, A.F.; Popoff, J.; Agarwal, K.; Meliopoulos, S. \"Approach to the analysis of Amtrak's systemwide grounding of the Northend Electrification Project\", Power Engineering Society Summer Meeting, 1999, Vol 1, pp.", " 451–456. .", "\n Sutherland, et al. ", "Analysis of Harmonics, Flicker and Unbalance of Time-Varying Single-Phase Traction Loads on a Three-Phase System, Paper No. ", "IPST05 - 091. ", "Retrieved 12/26/2010.", "\n\n60\nCategory:Electric railways in Connecticut\nCategory:Electric railways in Rhode Island\nCategory:Electric railways in Massachusetts\nCategory:Electric railways in the United States\nCategory:Electric power transmission systems in the United States\nCategory:Traction power networks\nCategory:Railway electrification in the United States\nCategory:25 kV AC railway electrification" ]

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[ "Q:\n\nAny Way to monitor JMX Servers with NetIq?", "\n\nI ask this question after a search in the site, there's many JMX questions but I think no one with a NetIq involved.", "\nIn the documentation of NetIq, There's no \"module\" to check JMX, but I have seen that u can make \"custom\" modules and \"custom\" scripts, in Perl and VbScript.", "\nThe question is if anyone with more experience than me on NetIq, has made any custom script or module to check JMX.", "\nI look on technet too, for a JMX Api for Windos Shell or Powershell with no luck.", "\nOf course, JMX is much more powerfull, but what I really need is to \"monitor\" some values inside NetIq, because we cant install Nagios, Cacti, Hyperic or any other monitor software but NetIq.", "\nThanks. ", "\n\nA:\n\nI am the Community Experience Manager at Qmunity, NetIQ's online community. ", "Have you asked the NetIQ user community, specifically the NetIQ AppManager Forum - I know someone could answer you there. ", "\n\n" ]

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[ "Perth Theatre Trust\n\nThe Perth Theatre Trust is a statutory authority which manages and operates cultural venues in Western Australia. ", "It manages His Majesty's Theatre, the State Theatre Centre of Western Australia, the Subiaco Arts Centre (leased from the City of Subiaco), the Albany Entertainment Centre, the Goldfields Arts Centre and the Perth Cultural Centre. ", "The Trust leases the Perth Concert Hall from the City of Perth but the venue is managed by WA Venue and Events. ", "The Trust also has a Museum of Performing Arts based in the His Majesty's Theatre building.", "\n\nHistory\nThe Trust was created in 1980 to manage theatre properties in the central business district of Perth, Western Australia. ", "This involved bringing the Perth Concert Hall and His Majesty's Theatre within a single administrative unit. ", "The Trust also incorporated and inherited records from preceding bodies, such as the National Theatre Company (W.A.) and the Perth Repertory Club, which had been established in 1919.", "\n\nThe now defunct Playhouse Theatre and the Subiaco Arts Centre were later included in the Trust's scope.", "\n\nActivities of the Trust included the re-opening of a renovated His Majesty's Theatre in 1980. ", "Activities included publications advertising theatre in Perth.", "\n\nFrom 2015, the Trust began to directly manage His Majesty's Theatre, the State Theatre Centre of Western Australia, Perth Concert Hall and Subiaco Arts Centre, after fifteen years of outsourcing operations to AEG Ogden.", "\n\nThe Trust leases the Goldfields Arts Centre in Kalgoorlie to the City of Kalgoorlie-Boulder. ", "On 1 July 2018, the Trust assumed responsibility for the management and activation of the Perth Cultural Centre precinct from the Metropolitan Redevelopment Authority.", "\n\nReferences\n\nExternal links\n \n\nCategory:1980 establishments in Australia\nCategory:Theatre in Australia" ]

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[ "Guy V de Laval\n\nGuy V de Laval (died 1210) was the Lord of Laval, Mayenne.", "\n\nFamily \nHe was the son of Guy IV de Laval and Emma de Dunstanville. ", "He married Avoise de Craon (died 1230), daughter of Maurice II de Craon. ", "They had issue:\n\n Guy VI de Laval known as Guyonnet de Laval (died 1211)\n Ozanne, mentioned in a charter of Réau Abbey, cited by Charles Maucourt de Bourjolly\n Emma de Laval (about 1200 - 27 April 1264) who inherited the title in 1211 on the death of her brother Guyonnet. ", "Married Robert Ier d'Alençon (died 1217), Mathieu II de Montmorency (died 1230) and Jean de Choisy et de Toucy.", "\n Isabeau (Isabelle) de Laval (died 1244) who married Bouchard VI de Montmorency.", "\n\nHistory \nIn the charters originating from him and in those which he countersigned, he called himself the fifth Lord of Laval of his name, not the seventh, as Blondel wrote, nor the fourth, as seen by Père Anselme: .", "\n\nComplaints about his harassment of the Abbey of Marmoutier and the domains it possessed in the district of Laval were referred to Pope Eugene III. ", "On Guy's refusal to make good the damage done, the pontiff ordered Guillaume Passavant, Bishop of Mans, to excommunicate him and to ban his land; an act exercised in 1150. ", "Guy, having had the censures lifted in 1152, founded Clermont Abbey in the same year, in conjunction with his mother and wife, for men of the Order of Cîteaux, and granted it a thousand arpents in pasture, arable land, and woodland.", "\n\nHenry, his brother-in-law, duke of Normandy and of Aquitaine, and Count of Anjou and Maine, came to the throne of England in 1154 and named him Regent and Lieutenant-General of the provinces of Anjou and Maine. ", "In 1170 he founded, in the chapel of his castle, twelve prebends, and had this confirmed by the bishop Guillaume; subsequently ratified in 1185 by Pope Lucius III. ", "In 1208 this chapter was transferred to Saint Tugal de Laval, and augmented by six prebends.", "\n\nNo ancient monument remains to indicate the year of death of Count Guy V.\n\nSee also \n House of Laval\n\nNotes and references \n\nCategory:Medieval French nobility\nCategory:12th-century French people\nCategory:House of Laval\nCategory:Year of birth unknown\nCategory:1174 deaths" ]

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[ "Liverpool came to defend, says Jose Mourinho\n\nManchester United manager Jose Mourinho said Liverpool had come to Old Trafford with the aim of stifling his side following Sunday’s 1-1 Premier League draw between the teams.", "\n\nUnited, chasing a 10th successive win in all competitions, fell behind to James Milner’s first-half penalty and needed an 84th-minute Zlatan Ibrahimovic header to rescue a point.", "\n\nJurgen Klopp’s Liverpool are the league’s top scorers with 49 goals, but Mourinho claimed their approach against United showed a different side to their game.", "\n\n“We were the team that attacked and Liverpool were the team that defended,” he told BBC Sport.", "\n\n“Let’s see if the critics are fair. ", "I enjoyed it, but I will obviously be disappointed we didn’t get the three points.", "\n\n“They were clever. ", "They took their time, they know how to play football and control the emotions of the game. ", "They knew they would be in trouble in the final few minutes.” ", "While Liverpool posed a steady threat on the counter-attack in the second half, United had the lion’s share of the play and duly levelled when Ibrahimovic looped in a header from Antonio Valencia’s cross.", "\n\n“I have a problem with my neck because I was always looking to the left side,” Mourinho quipped, in a reference to the end United were attacking during the second half.", "\n\nThe result kept United in sixth place, four points off the Champions League places and 12 points adrift of leaders Chelsea." ]

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[ "The Erythrina protease inhibitor: interactions with tissue plasminogen activator.", "\nThe Kunitz-type trypsin and tissue plasminogen activator (t-PA)-inhibitor from Erythrina caffra seeds was cleaved by trypsin at low pH to yield a disulphide linked two-chain molecule with reduced hydrophobicity. ", "This change was used to separate cleaved from native inhibitor by phenyl-Sepharose chromatography. ", "The inhibitor was not cleaved by t-PA. ", "Trypsin, but not t-PA, catalysed resynthesis of the cleaved bond. ", "Although the cleaved protein retained inhibitory activity for both trypsin and t-PA, 6-10 times higher concentrations were required for equivalent inhibition. ", "Removal of the active site arginine (Arg63) from the cleaved inhibitor by digestion with carboxypeptidase B resulted in a further loss of inhibitory activity towards both proteases. ", "The activity of the inhibitor could also be decreased by modification of one susceptible arginine residue with peptidyl arginine deiminase. ", "These results suggest that the trypsin-reactive site of the Erythrina inhibitor is also involved in the interaction between the inhibitor and t-PA." ]

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[ "hotpotpie commented on July 13, 2009\nMay Susan Boyle have a long and fulfilling career, and may she never, ever change in an attempt to look like almost all of the other stars. ", "We all fell in love with THE SUSAN BOYLE ORIGINAL, didn't we?" ]

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[ "Posts\n\nThe International Kissing Club by Ivy Adams is the story of four best friends: Piper, Cassidy, Mei, and Izzy--the misfits of Paris, Texas. ", "Their whole lives, they’ve dreamed of escaping small-town life and seeing the world. ", "So when Piper is the victim of an embarrassing prank that goes viral online, she gets the idea that the girls should escape via the school’s international exchange program, in search of fun, love and internet redemption.", "\n\nEmily McKay along with writing partners Shellee Roberts and Tracy Deebs writes under the pseudonym Ivy Adams. ", "They shop, gossip and watch movies in Austin, Texas.", "\n\nTop Ten Movies to watch when you’re home alone sick.", "\n\nI have to preface this blog with a story. ", "Back when my hubby and I were newly married, I had to have eye surgery for a detached retina. ", "Most people who detach a retina doing something cool and active, like sky diving or rappelling. ", "Not me. ", "My big hobbies are reading and baking and yoga. ", "So I hav…\n\nWell, in case you noticed (or maybe you didn't) I haven't been blogging in a while. ", "Even more of a shocker, I haven't been reading either. ", "It's quite absurd I know. ", "The result of me not doing either has been a snowstorm in October on the East Coast! ", "That's how off balanced I made the world!", "\n\nNo seriously, I just haven't felt like reading lately. ", "I'm not apologizing by any means. ", "Obviously this is my blog and I can do what I want! ", "Ok back to being serious, I'm just in a slump. ", "It's not because of what I'm reading because I was reading some fantastic books and I got a bunch of great ones lined up. ", "I think I was just pacing myself too much by trying to have a book reviewed every week day and if life got in the way, my schedule got screwed up.", "\n\nI think I will take things a bit more easier. ", "I don't have to compete with other book blogs and it's not like the publishers/authors/publicists will kill me if I don't put up a review when …\n\nSummary from BN.com: When young widow Lydia Gale helps a French prisoner obtain parole, she never dreams she will see him again. ", "But just as the London Season gets under way, the man presents himself in her parlor. ", "While she should be focused on getting her headstrong younger sister prepared for her entrée into Society, Lady Gale finds herself preoccupied with the mysterious Frenchman. ", "Is he a spy or a suitor? ", "Can she trust him? ", "Or is she putting herself and her family in danger?", "\n\nI don't why international stories don't fare as well in Christian fiction but I adore them. ", "I especially love stories that take place during the Regency era. ", "While I'm not a huge regency buff, I do enjoy the time period, fashions, customs and history of the era. ", "In this book, readers are introduced to characters who are debating with being loyal to their country or helping out those truly in need. ", "A masquerade ball takes on more than one meaning as national alliances are tested. ", "Romances with…\n\nSummary from BN.com: Katie Ann Stolzfus lives in the small Amish community of Canaan, Colorado. ", "At forty she is widowed and raising her first child. ", "But baby Jonas will never know his father, and Katie Ann wonders if her Heavenly Father hasn't forgotten about her as well. ", "Is it really God's plan for her to be a single parent?", "\n\nEli Detweiler has come to Canaan for a wedding and a long vacation. ", "Having raised six children following the death of his young wife, Eli is finally an empty-nester. ", "He's enjoying the slower pace of having no one to care for but himself.", "\n\nWhen Katie Ann and Eli meet, there is an instant connection. ", "Yet as strong as the attraction is, they both acknowledge that a romance would never work. ", "He is done parenting, while she has just begun.", "\n\nBut as their friendship slowly blossoms into feelings that are as frightening as they are intoxicating, Katie Ann and Eli question if the plans they made for themselves are in line with God's plans.", "\n\nSummary from LitFuse Publicity: Dottie Morgan has no desire to share her home - or her heart - over Christmas. ", "After all, her Christmas spirit froze over when Dottie lost her son in World War II. ", "But when a blizzard of the decade traps Dottie in her home with four near strangers, she just might discover that opening her door just might open her heart a Christmas miracle...and a new reason celebrate Christmas.", "\n\nYes, if you read this book you are going to have the title song stuck in your head pretty much the entire time you read it and long afterwards. ", "Interestingly even though the song has been around for a long time, I only first discovered it after the movie Elf came out. ", "I personally seem to have different connotations of the song than most people but I will admit that it is catchy and you can't get it out of your head.", "\n\nIt's just like this story. ", "Even though Susan May Warren is a favorite author of mine, lately I've been a little lukewarm towards her books. ", "They…\n\nSummary from BN.com: Alice Grace Ripley lives in a dream world, her nose stuck in a book. ", "But happily-ever-after life she's planned on suddenly falls apart when her boyfriend, Gordon, breaks up with her, accusing her of living in a world of fiction instead of the real world. ", "Then to top it off, Alice loses her beloved job at the library because of cutbacks due to the Great Depression.", "\n\nFleeing small-town gossip, Alice heads to the mountains of eastern Kentucky to deliver five boxes of donated books to the library in the tiny coal-mining village of Acorn. ", "Dropped off by her relatives, Alice volunteers to stay for two weeks to help the librarian, Leslie McDougal.", "\n\nBut the librarian turns out to be far different than she anticipated--not to mention the four lady librarians who travel to the remote homes to deliver the much-desired books. ", "While Alice is trapped in Acorn against her will, she soon finds that real-life adventure and mystery--and especially romance--are far better than her …\n\nSummary from BN.com: In 1904 Texas Ranger Luke Palmer arrives in Brenham, Texas, with one goal--to capture the gang of outlaws led by Frank Comer. ", "Undercover as a telephone repairman, he uses his days on the range to search, not realizing there's another pair of eyes watching him.", "\n\nGeorgie Gail, switchboard operator and birder, heads out on a birding expedition, but instead of sighting a painted bunting, her opera glasses capture her telephone man, armed and far away from telephone lines. ", "Palmer is forced to take this alluring troublemaker into his confidence and unwittingly puts her in harm's way. ", "The closer he comes to the gang, the further she works her way into his heart--and into trouble. ", "Soon it's more than just love that's on the line.", "\n\nIt's always funny how something can happen in real life and then you pick up a book and then find the same thing happening in the book. ", "Over the past weekend, I had gone to see the movie The Big Year, which is a movie about ex…\n\nSummary from BN.com: Jasmine Evans knows one thing for sure... people make mistakes. ", "After all, she is one. ", "Jaz is the result of a onenight stand between a black football player and a blonde princess. ", "Having a young mother who didn't raise her, a father who wants nothing to do with her and living in a small-minded town where she's never fit in hasn't been easy. ", "But she's been surviving. ", "Until she sees her mom's new boyfriend making out with her own best friend. ", "When do you forgive people for being human or give up on them forever?", "\n\nI can now declare that Janet Gurtler is one of my top five favorite YA contemporary writers of all time. ", "Seriously, after reading her two books, I am totally in love with her writing. ", "She pushes issues that teens deal with and need to be brought out in the open. ", "Since I read a lot of Christian fiction, one thing that I have major problems with that market is that it tends to be very few POC (person of color) main characters in the stor…\n\n21. ", "Cat purr vibrating through your skin22. ", "Jumping on a trampoline in the rain23. ", "Raw cookie dough24. ", "Getting yourself all freaked out after a scary movie25. ", "Dancing like an idiot when no one is watching\n\nWhat happened to the girl who wrote those things? ", "I miss that girl. ", "She used to be bold and fun. ", "Now she's a big chicken loser.", "How could so much change so fast?Let's see, you could be the plain Jane daughter of two gorgeous famous people, move to a new school, have no real friends, and your mom could get sick, and, oh yeah, you could have the most embarrassing secret in the world.", "Yep, that about does it.", "So, the real question is, how do I get that girl back?", "\n\nOk, the colorful cover fooled me into thinking this was going to be a light read. ", "I was expecting a cute story about what it means for a young teen girl to be happy. ", "I thought that this would be a quick read where I would go about my day after reading it. ", "I got a 1/4 of the way in th…\n\nIt is time for a FIRST Wild Card Tour book review! ", "If you wish to join the FIRST blog alliance, just click the button. ", "We are a group of reviewers who tour Christian books. ", "A Wild Card post includes a brief bio of the author and a full chapter from each book toured. ", "The reason it is called a FIRST Wild Card Tour is that you never know if the book will be fiction, non~fiction, for young, or for old...or for somewhere in between! ", "Enjoy your free peek into the book!", "\n\nWith a B.A. in English Literature from Hollins University and an M.F.A. in Creative Writing from Sarah Lawrence College, Hart serves as an inspirational speaker and creative writing instructor at conferences, retreats, schools, …\n\nSummary from BN.com: Tess is the exact opposite of her beautiful, athletic sister. ", "And that's okay. ", "Kristina is the sporty one, Tess is the smart one, and they each have their place. ", "Until Kristina is diagnosed with cancer. ", "Suddenly Tess is the center of the popular crowd, everyone eager for updates. ", "There are senior boys flirting with her. ", "But, the smiles of her picture perfect family are cracking and her sister could be dying. ", "Now Tess has to fill a new role: the strong one. ", "Because if she doesn't hold it together, who will?", "\n\nAs a lover of contemporary YA, I get very excited when I hear a new one has been released. ", "I had been hearing good things about Janet Gurtler and her books so I was very eager to read this one. ", "Let me start off by just saying, I loved how the inside of the cover of the book is a light shade of green. ", "You rarely see color INSIDE the book! ", "It was just a very nice touch. ", "And it set the setting for a lovely read." ]

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[ "Last week the Environmental Protection Agency’s (EPA) Science Advisory Board (SAB) panel on biogenic carbon emissions completed its final draft report providing recommendations for assessing biomass carbon emissions. ", "Assuming the full SAB approves the report later this spring, the work of the biogenic panel will finally conclude, providing yet another science reference to inform policy.", "\n\nNot surprisingly, the panel’s report confirms much of what we already know about determining the carbon neutrality of forest biomass – we should focus on actual changes in forest carbon or “carbon stocks;” we should consider long time frames to fully capture carbon change – the panel believes 100 years is reasonable; we should consider carbon stocks at broad geographic scales; and we should account for economic factors such as the impact of markets on forest investment, replanting and retention. ", "These conclusions reflect the position of forest carbon experts across the country, including the 100 prominent forest scientists from 80 universities who shared their views with EPA in a letter in November of 2014.", "\n\nYet, throughout its deliberations, the SAB panel complained of operating within a policy vacuum. ", "This raises once more the obvious point: We need a biomass policy.", "\n\nSome have argued that to avoid “legislating science” policy had to wait for the SAB panel to complete its work. ", "That wait is now over, and the panel’s findings confirm that waiting was not necessary in the first place. ", "Importantly, the panel was careful not to endorse any specific policy direction. ", "Even its preference for using complicated modeling and assumptions rather than field data did not insist on a specific approach. ", "That is because the decision whether to use models or data is ultimately a policy call, a point the panel clearly understands.", "\n\nCongress should now feel fully unfettered to adopt a biomass policy consistent with science and reliant on sound data. ", "With recent court decisions casting an even greater shadow of uncertainty on administrative action, the need for legislation is greater than ever. ", "The timing is right for Congress to act and provide the policy clarity that has been eluding us for far too long." ]

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[ "Q:\n\nHow to add time to datetime field for all rows in mysql table when field is part of a unique key?", "\n\nI am trying to do this:\nUPDATE `myTable` SET `time_stamp` = ADDTIME(`time_stamp`, '02:30:00');\n\nHowever, 'time_stamp' is part of my unique key, and I get an error:\n\"Duplicate entry '2014-09-22 18:30:00' for key 'time_stamp'\"\nIs there a better way to do this? ", "Do I have to go row by row starting from the latest time stamp? ", "Or do something tricky like subtract time by some huge amount first and then add time?", "\n\nA:\n\nI understand the question like you want to add 2h30m0s to every row in the table and that this is the reason, why you get your duplicate key error. ", "In this case, just order descending, so that you don't update rows to a value that already exists.", "\nUPDATE `myTable` \nSET `time_stamp` = ADDTIME(`time_stamp`, '02:30:00')\nORDER BY time_stamp DESC;\n\nIf you want to subtract however, you have to sort ASCending.", "\n\n" ]

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[ "FIRE-RESISTANT LANDSCAPING\n\nA fire-safe landscape isn’t necessarily the same thing as a well-maintained yard. ", "A fire-safe landscape uses fire-resistant plants that are strategically planted to resist the spread of fire to your home. ", "Fire resistant plants are great in California because they are often drought tolerant, too.", "\n\nThe good news is, you don’t need a lot of money to make your landscape fire safe. ", "And you will find that a fire-safe landscape can increase your property value and conserve water while beautifying your home.", "\n\nChoose Fire-Resistant Plants and Materials\n\nCreate fire-safe zones with stone walls, patios, decks and roadways.", "\n\nUse rock, mulch, flower beds and gardens as ground cover for bare spaces and as effective firebreaks.", "\n\nThere are no “fire-proof” plants. ", "Select high-moisture plants that grow close to the ground and have a low sap or resin content.", "\n\nChoose fire-retardant plant species that resist ignition such as rockrose, ice plant and aloe." ]

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[ "Q:\n\nIs there some way of getting sysname in libusb like edev?", "\n\nI need to get the device name of a device, which, by default, is on edev function:\nhttps://www.kernel.org/pub/linux/utils/kernel/hotplug/libudev/libudev-udev-device.html#udev-device-get-sysname\nudev_device_get_sysname ()\n\nconst char * udev_device_get_sysname (struct udev_device *udev_device);\nudev_device :\n\nudev device\nReturns :\n\nthe sys name of the device device\n\nBut all the work with the device are done in libusb, it would be terrible to use udev only for the sysname, and it's really strange that I cannot find similar functions in libusb.", "\nAnybody know about it?", "\nThanks in advance!", "\n\nA:\n\nFinally I solve it on my own, in a very stupid way.", "\nI got the busnum and devnum of a device in libusb, and iter all devices in udev, if a device has the same busnum and devnum, return it's sysname.", "\nI get busnum by udev api, devnum by cat /syspath/devnum.", "\nVid Pid won't work since same devices have same ids.", "\nHope this will be of help.", "\n\n" ]

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[ "Q:\n\nIncorrect Exit Code returned by Process.", "ExitCode Property\n\nI have a native C++ application that I am running as a process during the execution of a C++/CLI application and I am seeing some strange behaviour with the exit code. ", "I expect the exit code to be 0 when the process exits correctly but Process.", "ExitCode returns -529697949. ", "However, when I debug the C++ application I can see that the exit code being returned is actually 0. ", "Why would the Process.", "ExitCode property not match this value?", "\n\nA:\n\nThe absolute most important assumption to make when a program misbehaves is to never assume it is a bug in code that's used by hundreds of thousands of programmers and runs on half a billion machines. ", " Assume it is a problem in your program first.", "\nArmed with that knowledge, take a better look at the number. ", " A good strategy when the number looks large and random is always to convert it hex. ", " -529697949 = 0xe06d7363. ", " Shazam, magic number, googles well too. ", " That's the value of a Windows exception code. ", " e0 makes it a fatal error, 6d7363 are ASCII codes that spell \"msc\".", "\nYour program crashed on an unhandled C++ exception.", "\n\n" ]

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[ "/*\n * MIT License\n *\n * Copyright (c) 2017 Twitter\n *\n * Permission is hereby granted, free of charge, to any person obtaining a copy\n * of this software and associated documentation files (the \"Software\"), to deal\n * in the Software without restriction, including without limitation the rights\n * to use, copy, modify, merge, publish, distribute, sublicense, and/or sell\n * copies of the Software, and to permit persons to whom the Software is\n * furnished to do so, subject to the following conditions:\n *\n * The above copyright notice and this permission notice shall be included in all\n * copies or substantial portions of the Software.", "\n *\n * THE SOFTWARE IS PROVIDED \"AS IS\", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR\n * IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY,\n * FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. ", "IN NO EVENT SHALL THE\n * AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER\n * LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM,\n * OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE\n * SOFTWARE.", "\n */\n\n#include <iomanip>\n\n#include \"vireo/base_cpp.h\"\n#include \"vireo/common/enum.hpp\"\n#include \"vireo/common/math.h\"\n#include \"vireo/common/path.h\"\n#include \"vireo/demux/movie.h\"\n#include \"vireo/settings/settings.h\"\n#include \"vireo/util/util.h\"\n\nusing namespace vireo;\n\nvoid print_usage(const string name) {\n cout << \"Usage: \" << name << \" ref test\" << endl;\n}\n\nstruct Config {\n string ref = \"\";\n string test = \"\";\n};\n\nint parse_arguments(int argc, const char* argv[], Config& config) {\n if (argc !", "= 3) {\n cerr << \"Need to specify ref and test files\" << endl;\n return 1;\n }\n config.ref = argv[1];\n config.test = argv[2];\n return 0;\n}\n\ntemplate<class T>\nvoid print_diff(string error, string ref, string test, T ref_val, T test_val) {\n cout << error;\n cout << \": \";\n cout << ref << \" = \" << ref_val;\n cout << \", \";\n cout << test << \" = \" << test_val;\n cout << endl;\n}\n\nint main(int argc, const char* argv[]) {\n // Parse arguments\n if (argc < 3) {\n print_usage(common::Path::Filename(argv[0]));\n return 1;\n }\n Config config;\n if (parse_arguments(argc, argv, config)) {\n return 1;\n }\n\n __try {\n // Demux video files\n demux::Movie movie1(common::Path::MakeAbsolute(config.ref));\n demux::Movie movie2(common::Path::MakeAbsolute(config.test));\n\n // Compare file types\n if (movie1.file_type() !", "= movie2.file_type()) {\n print_diff(\"File types do not match\", config.ref, config.test,\n kFileTypeToString[movie1.file_type()],\n kFileTypeToString[movie2.file_type()]);\n return 1;\n }\n\n // Compare video settings\n const auto video_settings1 = movie1.video_track.settings();\n const auto video_settings2 = movie2.video_track.settings();\n if (video_settings1.codec !", "= video_settings2.codec) {\n print_diff(\"Video codecs do not match\", config.ref, config.test,\n settings::kVideoCodecToString[video_settings1.codec],\n settings::kVideoCodecToString[video_settings2.codec]);\n return 1;\n }\n if (video_settings1.width !", "= video_settings2.width ||\n video_settings1.height !", "= video_settings2.height) {\n stringstream res1; res1 << video_settings1.width << \"x\" << video_settings1.height;\n stringstream res2; res2 << video_settings2.width << \"x\" << video_settings2.height;\n print_diff(\"Video resolutions do not match\", config.ref, config.test, res1.str(), res2.str());\n return 1;\n }\n if (video_settings1.timescale !", "= video_settings2.timescale) {\n print_diff(\"Timescales of videos do not match\", config.ref, config.test,\n video_settings1.timescale,\n video_settings2.timescale);\n return 1;\n }\n if (video_settings1.orientation !", "= video_settings2.orientation) {\n print_diff(\"Orientations of videos do not match\", config.ref, config.test,\n settings::kOrientationToString[video_settings1.orientation],\n settings::kOrientationToString[video_settings2.orientation]);\n return 1;\n }\n if (video_settings1.codec == settings::Video::Codec::H264) {\n if (video_settings1.sps_pps.nalu_length_size !", "= video_settings2.sps_pps.nalu_length_size ||\n video_settings1.sps_pps.sps !", "= video_settings2.sps_pps.sps ||\n video_settings1.sps_pps.pps !", "= video_settings2.sps_pps.pps) {\n cout << \"SPS and PPS videos do not match\" << endl;\n return 1;\n }\n }\n\n // Compare audio settings\n const auto audio_settings1 = movie1.audio_track.settings();\n const auto audio_settings2 = movie2.audio_track.settings();\n\n if (audio_settings1.channels !", "= audio_settings2.channels) {\n print_diff(\"Audio channels do not match\", config.ref, config.test,\n (uint16_t)audio_settings1.channels,\n (uint16_t)audio_settings2.channels);\n return 1;\n }\n if (audio_settings1.timescale !", "= audio_settings2.timescale) {\n print_diff(\"Audio timescales do not match\", config.ref, config.test,\n audio_settings1.timescale,\n audio_settings2.timescale);\n return 1;\n }\n if (audio_settings1.sample_rate !", "= audio_settings2.sample_rate) {\n print_diff(\"Audio frequencies do not match\", config.ref, config.test,\n audio_settings1.sample_rate,\n audio_settings2.sample_rate);\n return 1;\n }\n if (audio_settings1.codec !", "= audio_settings2.codec) {\n print_diff(\"Audio codecs do not match\", config.ref, config.test,\n settings::kAudioCodecToString[audio_settings1.codec],\n settings::kAudioCodecToString[audio_settings2.codec]);\n return 1;\n }\n\n // Compare video sample count\n if (movie1.video_track.count() !", "= movie2.video_track.count()) {\n print_diff(\"Number of video samples do not match\", config.ref, config.test,\n movie1.video_track.count(),\n movie2.video_track.count());\n return 1;\n }\n\n // Compare audio sample count\n if (movie1.audio_track.count() !", "= movie2.audio_track.count()) {\n print_diff(\"Number of audio samples do not match\", config.ref, config.test,\n movie1.audio_track.count(),\n movie2.audio_track.count());\n return 1;\n }\n\n // Create a list of ordered samples\n vector<decode::Sample> samples1;\n vector<decode::Sample> samples2;\n for (const auto& sample: movie1.video_track) {\n samples1.push_back(sample);\n }\n for (const auto& sample: movie1.audio_track) {\n samples1.push_back(sample);\n }\n for (const auto& sample: movie2.video_track) {\n samples2.push_back(sample);\n }\n for (const auto& sample: movie2.audio_track) {\n samples2.push_back(sample);\n }\n auto sample_compare = [](const decode::Sample& a, const decode::Sample& b) {\n return a.byte_range.pos < b.byte_range.pos;\n };\n sort(samples1.begin(), samples1.end(), sample_compare);\n sort(samples2.begin(), samples2.end(), sample_compare);\n\n // Compare sample order and samples\n for (uint32_t i = 0; i < samples1.size(); ++i) {\n const auto& sample1 = samples1[i];\n const auto& sample2 = samples2[i];\n if (sample1 !", "= sample2) {\n cout << \"Sample \" << i << \" in the files do not match\" << endl;\n return 1;\n }\n }\n\n // Compare sample payloads - do separately to fail fast for metadata mismatches\n for (uint32_t i = 0; i < samples1.size(); ++i) {\n const auto& nal1 = samples1[i].nal();\n const auto& nal2 = samples2[i].nal();\n if (nal1 !", "= nal2) {\n cout << \"Payloads of sample \" << i << \" do not match\" << endl;\n return 1;\n }\n }\n cout << \"Files are functionally identical\" << endl;\n } __catch (std::exception& e) {\n cout << \"Unsupported video files, comparing binaries\" << endl;\n __try {\n auto ref = common::Data32(common::Path::MakeAbsolute(config.ref));\n auto test = common::Data32(common::Path::MakeAbsolute(config.test));\n if (ref !", "= test) {\n cout << \"Binary files differ\" << endl;\n return 1;\n }\n } __catch(std::exception& e) {\n cerr << \"Error comparing files: \" << e.what() << endl;\n return 1;\n }\n cout << \"Files are identical\" << endl;\n }\n return 0;\n}\n" ]

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[ "WITHDRAWN: A Descriptive Review Article for Pump Initiation in a Pediatric Diabetes Centre.", "\nThe Publisher regrets that this article is an accidental duplication of an article that has already been published, DOI of original article:10.1016/j.pedn.2013.01.005. ", "The duplicate article has therefore been withdrawn." ]

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[ "Paying the physician's fee: Blue Shield and the reasonable charge.", "\nAt a time of debate over physicians' fees and income, we describe the evolution of Blue Shield plans and programs to pay physicians' fees. ", "We review how Medicare's \"reasonable-charge\" formulas fostered Blue Shield \"usual, customary, and reasonable\" (UCR) contracts. ", "In a three-year period in the Washington, DC, area, Blue Shield UCR protocols permitted \"customary\" allowances for selected surgical procedures to rise 29 to 75 per cent; charges by two physicians increased allowances for coronary-artery bypass from $2000 to $3500. ", "We find little justification for secrecy in fee-payment protocols. ", "Physicians dominate the District of Columbia Blue Shield Board and its committees, and they control fee-payment formulas. ", "Nationally, 61 per cent of Blue Shield boards have majorities of health-care providers; approximately two thirds of fee-related committees have physician majorities. ", "We urge increased public debate, public representation, and accountability in monitoring and reforming the programs that we describe." ]

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[ " NONPRECEDENTIAL DISPOSITION\n To be cited only in accordance with\n  Fed.", " R. App.", " P. 32.1\n\n\n\n\n United States Court of Appeals\n For the Seventh Circuit\n Chicago, Illinois 60604\n\n Submitted September 22, 2014*\n Decided September 23, 2014\n\n Before\n\n RICHARD D. CUDAHY, Circuit Judge\n\n RICHARD A. POSNER, Circuit Judge\n\n MICHAEL S. KANNE, Circuit Judge\n\nNos.", " 13‐2427 & 13‐2535\n Appeals from the United States District \nYOLANDA D. YOUNG‐SMITH, Court for Northern District of Indiana,\n Plaintiff‐Appellant, Cross‐Appellee, South Bend Division.", " \n v.\n No.", " 3:12‐cv‐00275\nREBECCA A. HOLT, et al.,", "\n Defendants‐Appellees, Philip P. Simon,\n Chief Judge.", "\n and\n\nSTEPHEN A. YOKICH,\n Defendant‐Appellee, Cross‐Appellant.", "\n\n\n\n\n *\n After examining the parties’ briefs and the record, we have concluded that oral\nargument is unnecessary.", " See FED.", " R. APP.", " P. 34(a)(2)(C).", "\n\fNos.", " 13‐2427 & 13‐2535 Page 2\n\n O R D E R \n\n Yolanda Young‐Smith appeals the dismissal without prejudice of her civil‐rights\nlawsuit.", " Stephen Yokich cross‐appeals to obtain a dismissal with prejudice.", " This case\narises out of another suit that Young‐Smith brought against her former employer (Bayer\nHealthcare) and her union for employment discrimination.", " She alleges that attorneys in\nthe employment suit and others conspired to violate various laws in order to defeat her\nin that case.", " The court dismissed Young‐Smith’s complaint for lack of a substantial\nfederal question.", " We affirm the dismissal because Young‐Smith failed to raise a\nsubstantial federal question, but clarify that part of the dismissal is with prejudice.", " \n\n According to Young‐Smith, whose factual allegations we must take as true, Bayer\nfired her from her job as an hourly worker because she is black and her union failed to\ngrieve the discharge adequately.", " Young‐Smith sued both Bayer and the union for race\ndiscrimination.", " She later settled with Bayer, and the district court granted the union\npartial summary judgment, but allowed one claim against the union to proceed to trial;\nthe case is still pending.", " \n\n Young‐Smith then filed this lawsuit to challenge conduct that occurred in the\nemployment suit.", " Her complaint accuses private actors—her attorney, the union’s\nattorney, former co‐workers, and others—of lying to the court, defaming her during\ncourt proceedings, and refusing to produce some documents.", "  Among other laws, she\ncites 42 U.S.C. § 1985, the federal statute prohibiting conspiracies to violate civil rights,\nand notes that she is black and the defendants are white.", " \n\n After she filed this lawsuit, Young‐Smith asked the judge in the employment\ncase, Judge Lee, to consider her claims of fraud on his court.", " He allowed her to submit\nher evidence of a fraud conspiracy, and after she supplied her evidence she asked him\nto rescind her settlement agreement with Bayer and vacate the court’s grant of partial\nsummary judgment to the union.", " After considering the evidence, Judge Lee concluded\nthat no fraud occurred and denied Young‐Smith’s motions.", "\n\n Meanwhile the defendants in this case moved to dismiss it.", " They argued that no\nsubstantial federal claims supported subject‐matter jurisdiction.", " Defendant Stephen\nYokich, the union’s lawyer, added that Young‐Smith failed to state a claim for fraud\nbecause her exclusive remedy for fraud was in the employment suit and her defamation\nclaim failed because an absolute litigation privilege shields statements he made there.", "\n(Yokich did not argue that, in light of Judge Lee’s ruling, claim preclusion bars the\n\fNos.", " 13‐2427 & 13‐2535 Page 3\n\nfraud claim; likewise on appeal Yokich tells us that, because the employment case is still\npending, Young‐Smith remains free to continue litigating her fraud claim there.)", " \n\n The district court granted the motion to dismiss.", " It described Young‐Smith’s\ncomplaint as a long, “machine gun spray of allegations” of state‐law violations,\npeppered with haphazard citations to federal statutes.", " Without any facts supporting a\nfederal question, though, the court concluded that Young‐Smith’s complaint lacked\nsubject‐matter jurisdiction.", " It then dismissed all claims without prejudice.", " Both\nYoung‐Smith and Yokich moved the court to reconsider.", " Young‐Smith maintained that\nthe fraud conspiracy created a federal question, and Yokich argued that the dismissal\nshould be with prejudice because, although Judge Lee found no fraud, he treated the\nquestion as substantial.", " Still seeing no federal question, the court denied both motions,\nand the parties appeal.", "\n\n Young‐Smith raises three main arguments on appeal.", " She first contends that her\ncase presents a federal question because she accuses private actors of conspiring to\ninterfere with her right to sue, misconduct for which she contends that 42 U.S.C. § 1985\nprovides a remedy.", " But to invoke federal jurisdiction under § 1985 non‐frivolously,\nYoung‐Smith needed to allege that the defendants conspired to deprive her of\nconstitutional rights because of her race.", " See 42 U.S.C. § 1985(2), (3); Griffin v. Breckenridge,\n403 U.S. 88, 102–03 (1971); Chavis v. Clayton County School District, 300 F.3d 1288,\n1291–92 (11th Cir.", " 2002).", " Although her complaint is littered with references to a\n“conspiracy,” that legal term gets her nowhere.", " See Ashcroft v. Iqbal, 556 U.S. 662, 681\n(2009); Bell Atlantic Corp. v. Twombly, 550 U.S. 544, 555–56 (2007).", " She never alleges that,\nbecause of her race, the defendants conspired to defraud Judge Lee into rejecting her\nemployment suit.", " Without an allegation of racial animus, Young‐Smith’s reference to\n§ 1985 did not create a substantial federal question.", " (We have considered the other\nfederal statutes she cites, but in the district court and here she did not develop serious\narguments about them, so they are forfeited.)", " \n\n The remainder of Young‐Smith’s complaint creates no federal question either.", "\nShe raises claims of perjury, conspiracy to commit perjury, fraud, legal malpractice,\nintentional infliction of emotional distress, and defamation.", " But these are all questions\nof state law.", " See, e.g., Ball v. City of Indianapolis, ___ F.3d ___, 2014 WL 3673466 at *6 (7th\nCir.", " July 25, 2014) (perjury and fraud); Rosenbaum v. White, 692 F.3d 593, 600 (7th Cir.", "\n2012) (legal malpractice); Parish v. City of Elkhart, 614 F.3d 677, 679 (7th Cir.", " 2010)\n(intentional infliction of emotional distress); Baravati v. Josephthal, Lyon & Ross, Inc., 28\n\fNos.", " 13‐2427 & 13‐2535 Page 4\n\nF.3d 704, 707 (7th Cir.", " 1994) (defamation).", " Because Young‐Smith does not assert\ndiversity jurisdiction, these claims do not support federal question jurisdiction.", "\n\n Young‐Smith’s two remaining arguments are also baseless.", " First she contends\nthat in dismissing her complaint the district court improperly considered a matter\noutside the pleadings—Judge Lee’s order rejecting the fraud claim.", " But a court may take\njudicial notice of matters of public record such as a court order.", " See Gienosky v. City of\nChicago, 675 F.3d 743, 745 n.1 (7th Cir.", " 2012); United States v. Wood, 925 F.2d 1580,\n1581–82 (7th Cir.", " 1991); Funk v. Stryker Corp., 631 F.3d 777, 783 (5th Cir.", " 2011).", " Second\nYoung‐Smith argues that the district court should have stayed this suit until final\njudgment is entered in her employment case; that way, if the adverse fraud ruling there\nbecomes conclusive, she may later resume her fraud claims here.", " But once the court\nenters a final judgment in the employment case, claim preclusion would bar her fraud\nclaims here.", " See Taylor v. Sturgell, 553 U.S. 880, 892 (2008).", " A stay thus would have been\npointless.", " \n\n We come to Yokich’s cross‐appeal, in which he presents two arguments.", " He first\ncontends that Young‐Smith’s claim of a conspiracy to defraud Judge Lee should have\nbeen dismissed with prejudice because her exclusive remedy for that claim is in the\nemployment case.", " He is correct that the dismissal should be with prejudice, but we need\nnot decide whether Young‐Smith’s only recourse for fraud was before the allegedly\ndefrauded court.", " A claim that presents no substantial federal question necessarily states\nno federal claim; it therefore, “can justifiably be dismissed with prejudice to avoid\nburdening the court system with a future suit that should not be brought—anywhere.”", "\nGeorgakis v. Illinois State University, 722 F.3d 1075, 1078 (7th Cir.", " 2013); see El v.\nAmeriCredit Financial Services, Inc., 710 F.3d 748, 751 (7th Cir.", " 2013).", " Because her\nconspiracy‐to‐defraud claim did not raise a substantial federal question, the district\njudge should have dismissed it with prejudice for failure to state a federal claim.", " \n\n Yokich next argues that the district court should have dismissed with prejudice\nthe supplemental state‐law defamation claim against him, but we disagree.", " If a\nsubstantial federal claim is dismissed before trial, the court retains supplemental\njurisdiction to dismiss a frivolous state‐law claim.", " See Sellars v. City of Gary, 453 F.3d 848,\n852 (7th Cir.", " 2006).", " But a frivolous federal claim, like Young‐Smith’s conspiracy claim, is\ntoo insubstantial to confer federal jurisdiction, so it cannot support supplemental\njurisdiction to decide a state‐law claim.", " See, e.g., Arena v. Graybar Electric Company, Inc.,\n669 F.3d 214, 221–22 (5th Cir.", " 2012); Musson Theatrical, Inc., v. Federal Express Corporation,\n89 F.3d 1244, 1255 (6th Cir.", " 1996); Plott v. Griffiths, 938 F.2d 164 (10th Cir.", " 1991).", " Yokich\n\fNos.", " 13‐2427 & 13‐2535 Page 5\n\nreplies that Young‐Smith’s fraud claims were substantial because Judge Lee addressed\nthem.", " True, they may have been substantial in the sense that they fell within Judge\nLee’s inherent power to police his own court.", " But as Yokich concedes, fraud‐on‐the‐\ncourt claims do not independently supply another federal court with federal‐question\njurisdiction if a federal law has not been violated, and Yokich does not identify one.", "\nWithout any substantial federal question in the district court, the defamation claims\nwere properly dismissed without prejudice.", " \n\n Accordingly, the district court’s judgment is AFFIRMED AS MODIFIED to\nreflect that the fraud claim against Yokich is dismissed with prejudice for failure to state\na federal claim.", "\n\f" ]

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[ "CT evaluation of extrahepatic disease in patients with metastatic colorectal carcinoma receiving hepatic arterial chemotherapy.", "\nComputed tomography (CT) of the abdomen and pelvis in 88 patients with hepatic metastases from colorectal carcinoma undergoing hepatic arterial chemotherapy has been reviewed. ", "Extrahepatic disease was present as determined by CT examination in 83 (94%). ", "Tissue proof was available for 23 sites in 19 patients, with the most common sites being retroperitoneal lymph nodes (5), lung (3), abdominal wall (3), and peritoneum or mesentery (3). ", "Clinical proof was obtained for 78 sites in 51 patients, the most common being lung (20), retroperitoneal lymph nodes (19), and porta hepatis lymph nodes (12). ", "CT detection of extrahepatic disease is useful, since its presence has prognostic and therapeutic implications." ]

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[ "Could Coffee Hold the Key to Longevity?", "\n\nCoffee Linked to Longer Lifespan, Say Researchers\n\nIf you're like me, a good cup of hot coffee in the morning is the only way to start a fabulous day.", "\n\nSome researchers are now claiming that this wonderful caffeinated elixir made in millions of coffee machines around the world every day may not only taste good, it may prolong your life. ", "If this is true, coffee shop patrons could soon be dancing in the streets - for a few more years than they expected.", "\n\nThis particular report linking coffee and longevity was recently published in the highly respected New England Journal of Medicine. ", "The research was actually done by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Division of Cancer Epidemiology and Genetics.", "\n\nResearchers kept track of over 400,000 men and women aged 50 to 71 years of age for a period of 13 years. ", "You can see the results of the study here.", "\n\nThe research found that folks who had more than two or more cups of coffee per day were at less risk of dying from certain specific diseases that affected non-coffee drinkers. ", "Basically, those who drink coffee may enjoy the benefits of longevity.", "\n\nThat's got to be great news for those of us who love coffee, however, before you skip off to the local coffee shop whistling a happy tune, consider the following information...\n\n.", "\n\nThat magical brew made in millions of coffee machines around the world may have many health benefits. ", "| Source\n\nCoffee Drinkers Less Likely to Die As Soon\n\nWhile researchers found coffee drinkers do indeed live longer and may not be affected as much by diseases of non-coffee drinkers, they could not pin down the specific ingredients in coffee that may protect coffee drinkers from various diseases.", "\n\nSure, there are a load of beneficial antioxidants, flavenoids and unique compounds combined together in a cup of coffee, but what are the specific ingredients of this longevity elixir that are dispensed from coffee makers? ", "Well, they haven't figured that part out just yet.", "\n\nThe best news from this research is that coffee drinkers did not die as early due to respiratory diseases, heart disease, diabetes, stroke, infections, accidents or other injuries. ", "Those who consumed more coffee were less likely to suffer as early from these conditions.", "\n\nThe research found that these coffee shop patrons lowered their risk of death by as much as 16 percent. ", "Does that mean if I drink more than two cups of coffee each day I'll live 16 percent longer? ", "Hmm, maybe I should ponder this over a cup of coffee?", "\n\n.", "\n\nMore Coffee,: Up to 16% Longer Life\n\nSo I started thinking about this research and I reckoned that if I drink more coffee, I should get more health benefits and live even longer, right?", "\n\nDoes drinking more coffee increase longevity? ", "Research seems to indicate a connection. ", "| Source\n\nWell, researchers aren't quite sure and there is no one researcher who is willing to make that claim. ", "I mean, imagine the runs on coffee shops! ", "Sales of coffee machines would skyrocket and coffee supplies might become dangerously low.", "\n\nThat is not likely to happen, however, the research did bear out the following interesting information:\n\nFemale coffee drinkers who consumed two or three cups of coffee each day were not as likely to die as soon female non-coffee drinkers.", "\n\nThat's a 13 percent better chance of avoiding disease and living longer for coffee drinkers.", "\n\nThose women who had four to five cups of coffee enjoyed a 16 percent better chance of avoiding disease and living longer.", "\n\nFor men, the benefit was not quite that high.", "\n\nMale coffee drinkers could lower their chance of disease and death by 10 percent.", "\n\nAlthough they only studied those who drank as many as six cups, researchers also discovered that drinking more coffee increased the chances of living longer.", "\n\n.", "\n\nIf coffee does increase human lifespans, coffee shops could become the most popular spots on the planet. ", "| Source\n\nIs Coffee the Magic Elixer of Longevity?", "\n\nSo, should you just take coffee intravenously throughout the day to get even more benefits of longevity?", "\n\nOr perhaps coffee makers could come with an IV tube that puts coffee right into your vein.", "\n\nMaybe multiple visits to the coffee shop will get you a better rate on your life insurance.", "\n\nNone of those things are likely to happen just yet.", "\n\nAs much as I would like to claim that there is absolute, definitive proof that coffee extends longevity, the research just doesn't go that far. ", "While it is true there seems to be a link between drinking coffee and longer life, researchers admitted that the study was more observational than actually clinical.", "\n\n.", "\n\nCoffee and Longevity...\n\nThe Bottom Line on Coffee and Health\n\nApparently coffee consumption is good for you and can indeed affect longevity. ", "There is enough evidence of this to warrant further research and that is the good news.", "\n\nBenefits of coffee found in other recent studies include a lowered risk of heart disease, Type 2 diabetes, Parkinson's disease, Alzheimers's diseases, dementia and depression. ", "All good benefits from drinking coffee.", "\n\n.", "\n\nCoffee Preparation is Important\n\nOne word of advice on preparing your next cup of coffee. ", "The way in which you prepare your coffee does have an effect on the health benefiting compounds therein. ", "Kahweol and cafestrol have been proven to raise LDL cholesterol levels in the bloodstream.", "\n\nLDL is the \"bad\" cholesterol that causes damage to the body's arteries. ", "These unhealthy substances are removed when coffee is prepared using a filter.", "\n\nThese potentially harmful chemicals remain in espresso, boiled coffee and coffee prepared in a French press.", "\n\nMost all commercial and consumer coffee machines use a filter to remove cafestrol and kahweol. ", "Single serve coffee machines like the Keurig® also utilize a filter.", "\n\nOne last thing, the research did not take into account flavored coffees or coffee with large amounts of sugar and creamers. ", "These things add their own risks to coffee so keep that in mind as you enjoy your coffee. ", "Another consideration is the amount of caffeine present in coffee.", "\n\nAs a coffee drinker, I think this is good news overall. ", "So with all of this in mind, I raise my morning cup of coffee and proclaim, \"to life!\"", "\n\nThe information in this article is provided as a information resource only. ", "This information should not used for treatment or diagnosis of any medical conditions. ", "As a first step, always consult your physician or healthcare professional before making any decision or assessment regarding any possible medical condition.", "\n\nComments 7 comments\n\nWhat a great news! ", "I love coffee, I have a few cups a day, and I look forward to it every morning. ", "Thanks for very interesting hub!", "\n\nbillybuc 3 years ago from Olympia, WA\n\nInteresting! ", "Are we talking just coffee, or coffee drinks like mochas, because I really do not like regular coffee, but I do have two mochas each week....not daily, just two per week. :)", "\n\nbotipton 3 years ago from Cecilia, KY\n\nThis is great news. ", "This means I will probably live to be 200. ", "Very interesting information and worth looking into further and seeing what else they find.", "\n\nMKayo 3 years ago from Texas Author\n\nMonis Mas. ", "BB and botipton - Thanls for the read and taking time to leave a comment - you're all so kind. ", "BB, not sure about mochas, i think the research was just coffee - so you're on you own there. ", "Botipton, may we all live to be 200! ", "Me, I'm making another cup on this cold winter's day!", "\n\nsavingkathy 3 years ago from Ontario, Canada\n\nVery interesting. ", "I think this is great news, since I do love my coffee!", "\n\npstraubie48 3 years ago from sunny Florida\n\nWow...so much I did not know I knew that makes me happy I enjoy this lovely drink. ", "I usually do not have four cups a day but I can fix that. :)", "\n\nThanks for sharing this...\n\nSending Angels to you this tenth day of the new year.. :) ps\n\nMKayo 3 years ago from Texas Author\n\nThanks for reading savingkathy and pstraubie48 - and for the kind words!" ]

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[ "Pokkén Tournament was one of only two Pokémon titles to grace the Wii U; less than the four new titles on the Nintendo GameCube and six on the Nintendo Wii. ", "While it sold over a million units (a fair effort given the Wii U’s userbase), the game lacked the updates seen granted to the arcade version, such as new fighters. ", "Only now do we see them in the new version for the Nintendo Switch. ", "But is Pokkén Tournament DX a true improvement over its predecessor, and does it do well as the first title on the Nintendo Switch when considered by itself?", "\n\nTable of Contents\n\nSummary\n\nFor those not in the know, Pokkén Tournament DX is a 3D fighting game developed by Bandai Namco Games – basically a Pokémon version of Tekken. ", "There’s a few twists added to the usual formula of combos; for instance, three types of attacks exist with a rock-paper-scissors aspect involved, where normal attacks beat grabs, grabs overcome counter attacks, and counters defeat normal attacks. ", "There’s also the two different phases; Field Phase is one where fighters can run freely in any direction, while Duel Phase has characters restricted to moving relative to each other. ", "Landing strong attacks switches you between these phases, and it appears to be an answer to breaking the chance of infinite combos occurring. ", "Ultimately it feels a little awkward but it does add some variety to battles.", "\n\nAdding to this is a myriad of Support Pokémon which can attack, boost or heal you, and a Synergy Gauge which charges as you attack or collect energy during the Field Phase. ", "This comes with a significant stat boost for a short amount of time, and the chance to perform a Burst Attack – a powerful strike that comes with a fancy cutscene unique to each Pokémon. ", "Overall you have the makings of a solid battling system, and much is centred on Pokémon, with a few creative liberties here and there. ", "Suicune’s Burst Attack involving so much ice, or Scizor seemingly been more of a robot than living bug are instances that stand out, but otherwise it’s sensible enough.", "\n\nLevels exist too for the single player modes. ", "As you use a fighter, it gains experiences and levels. ", "Each level grants a Skill Point that can be spent on Attack, Defense, Synergy, or Strategy (use of Supports), and these add up. ", "They have no bearing on multiplayer modes however.", "\n\nThese features were all part of the original Pokkén Tournament for Wii U release, and nothing has been added in terms of gameplay mechanics beyond some balancing of attack power or the like. ", "Luckily a few modes and bonuses have been added in, alongside Pokémon." ]

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[ "Q:\n\nMongoDB Tags Key Indexing\n\nGoing over some of the tutorials I have found MongoDB: get documents by tags, it seems that most tags are created as list of items. ", "In my schema I want dynamic tags (key-value pairs), so every item in the collection has a tags field like the following entry:\n{\"tags\" : {\"key1\" : \"value1\", \"key2\", \"value2\"}}\n\nHowever I'd like indexing on the keys inside the tags field. ", "AFAIK, this is not possible (even with multikey indexes), since the keys can be arbitrary?", "\nWill I need to migrate the schema to look like:\n{\"tags\" : [{\"key1\" : \"value1\"}, {\"key2\" : \"value2\"}]}\n\nIf so would my index look like:\ndb.foo.ensureIndex({\"tags\" : 1})\n\nAs suggested here:\nhttp://www.mongodb.org/display/DOCS/Using+Multikeys+to+Simulate+a+Large+Number+of+Indexes\n\nA:\n\nYes, you can index over an array of subdocuments as tags, but you always need to query for the complete sub-document. ", "create the index as you stated above with \ndb.foo.ensureIndex({'tags': 1})\n\nand query with:\ndb.foo.find('tags': {'key1': 'value1'}) \n\nThis will use the index and return all documents that have that particular sub-document in their tags array.", "\n\n" ]

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[ "Substrate specificity of human RNase H1 and its role in excision repair of ribose residues misincorporated in DNA.", "\nRecently we have shown that the major isoform of RNase H in human cells, RNase H1, is able to cleave DNA substrates containing a single RNA-DNA base pair, an activity which appears to be involved in an excision repair system for the removal of ribose residues misincorporated into DNA. ", "In the present work we have further characterized the substrate specificity of the enzyme. ", "DNA substrates containing all four ribonucleotides are cleaved by the enzyme. ", "A RNA-DNA base pair is not required for substrate recognition. ", "RNA residues present within a mismatch or in a RNA-RNA base pair are also cleaved. ", "The principal structural feature for recognition by the enzyme may simply be the presence of the 2'-OH group of the ribose residue adjacent to the cleavage site." ]

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[ "Background: The selection of the correct donor lung is crucial for a successful lung transplant. ", "Since the median survival after lung transplant is 5 years and the morbidity and mortality of lung transplant is higher than other transplants, it is crucial to preselect the correct recipient. ", "Methodology: In India, Dr. P. Venugopal at the All India Institute of Medical Sciences, New Delhi, performed the first successful heart transplant, while Dr. K. M. Cherian performed the first heart–lung transplant at Chennai. ", "At Apollo Hopsitals, Chennai, the first heart transplant was performed by Dr. M. R. Girinath. ", "Subsequently, the Department of Heart and Lung Transplantation at Apollo Hospitals, Chennai, have performed a large number of heart and lung transplants and its experience is summarized. ", "Results: The Department of Heart and Lung Transplantation at Apollo Hospitals, Chennai, has done 101 lung and 62 heart transplants as part of their lung and heart lung transplant program. ", "There were 21 heart–lung transplants and 25 double lung transplants. ", "The results are discussed and indications, contraindications for lung and heart–lung transplant as well as recipient and donor workup are discussed in this first part of a set of three articles. ", "Conclusions: Careful selection of a recipient and donor leads to a successful lung and heart–lung transplant program.", "\n\nLung transplantation in humans was first attempted almost 55 years ago by James Hardy in 1963.[1] There were a lot of problems in the initial decades because of rejection and anastomotic site healing. ", "Rejection rates improved with the introduction of cyclosporin. ", "Improved surgical techniques were also devised.", "\n\nThere were no long-term survivors for two decades. ", "About 44 patients worldwide underwent lung transplant with no long-term survivors.[2] It was only in 1983 that Joel Cooper reported the first successful single lung transplant in humans.[3] Gradually, with better surgical techniques and better understanding of the lung transplant physiology and immunology, the results improved and now the survival is 80% at 1 year, 65% at 3 years, and 54% at 5 years [Figure 1].", "\n\nIn India, the first successful heart transplant was performed at All India Institute of Medical Sciences by Dr. P. Venugopal [Figure 2] in 1994.[4] The first successful heart–lung transplant in India was performed by Dr. KM Cherian [Figure 3] at Chennai.[5] At Apollo Hospitals, Chennai, the first heart transplant was performed by Dr. M. R. Girinath [Figure 4] in 1995. ", "At that time, there was no formal transplant program and sporadic cases were performed in the next 2 years with varying results and subsequently, no further heart transplants were done. ", "A formal Cardiothoracic Transplant program at Apollo Hospitals, Chennai, was envisioned by the transplant team of Dr. Paul Ramesh and Dr. T. Sunder, cardiothoracic surgeons and their first step was to develop a multidisciplinary team of specialists who were passionate about transplant and the department was built and protocols developed – largely from the Papworth Hospitals in the UK. ", "The transplant program was largely a surgeon-led program. ", "The first heart transplant successfully done by this group was in 2006. ", "Over the years, problems specific to the Indian scenario were encountered and protocols were tailored to meet Indian conditions.", "\n\nFigure 2: Dr. P.Venugopal who performed first heart transplant in India.", "\n\nThe first heart–lung transplant at Apollo Hospitals, Chennai, and second in India was performed by Dr. Paul Ramesh and Dr. T. Sunder in 2007. ", "With the experience gained in dealing with heart transplants in Indian patients, both recipients and donors, the team commenced the lung transplant program. ", "In 2011, the transplant team grew with addition of Dr. Madhan Kumar – also a cardiothoracic surgeon. ", "In 2016, Dr. Suresh Manickavel, transplant physician and pulmonologist joined the Apollo Heart and Lung Transplant team [Figure 5]. ", "At Apollo Hospitals, Chennai, the first isolated lung transplant was performed in 2011 by Dr. Paul Ramesh, Dr. Madhan Kumar, and Dr. T. Sunder, which was a single lung transplant. ", "The unit has then progressed to performing double lung transplants and preferentially performs double lung transplants whenever possible.", "\n\nLive-related Kidney transplants were performed since 1983 when the Hospital started functioning under the stewardship of Dr. Mani. ", "After the passing of the Transplantation of Human Organs Act in 1994, cadaveric-deceased donor kidney transplants are being regularly done.", "\n\nSome of the problems faced by the lung transplant units in India[5] include late referral, reluctance of physicians to refer cases due to lack of confidence in surgical outcomes, bed bound and sick patients who have developed myopathies and are therefore not very good surgical patients, ventilator dependence of patients, ventilator-associated pneumonia and graft dehiscence, and tubercular infection both in the recipient and the donor.", "\n\nSelection of the lung for lung transplant and the correct recipient is crucial for a successful lung transplant. ", "The indications for lung transplant have been detailed by the pulmonary transplantation council of the International Society for Heart and Lung Transplant 2014. ", "Referral for lung transplant should occur early in end-stage lung disease, but the guidelines for India need to be evolved with experience and time. ", "This document will try to document the experience of one hospital as a model and then try to document the experiences of other hospitals similarly to evolve a consensus.", "\n\nMethodology\n\nThe AIIMS and Apollo Hospital Chennai are organizing a series of 3 hands on workshops on heart–lung transplant [Figure 6]. ", "The proceedings will be published in this journal and will act as a starting point for hospitals who want to start their own transplant programs.", "\n\nFigure 6: Participants of the lung transplant workshop at AIIMS, New Delhi.", "\n\nThe selection process for the donor and recipient is highlighted in this document and the Indian experience for each component is expanded by the Apollo experience.", "\n\nResults\n\nThe Heart and Lung Transplant Team, Apollo Hospitals, Chennai, has assessed a total of about 154 patients and transplanted 163 organs in 94 patients. ", "This includes 101 lungs and 62 hearts. ", "There were 39 heart transplants with three bridge to transplants where two were bridged from a ventricular-assist device and one from an extracorporeal membrane oxygenator. ", "There were 21 combined heart and lung transplants. ", "There was one combined heart–lung and kidney transplant. ", "There was one combined heart and liver transplant, which was an en bloc heart–liver transplant, the first of its kind in Asia. ", "There were 25 double lung transplants including one bridged from an extracorporeal membrane oxygenator. ", "There were seven single lung transplants including one being bridged from a ventilator. ", "Postsurgery, 89.3% of the heart transplant patients were doing well and 73% of the lung transplant patients were doing well (80% survival in primary pulmonary hypertension and 67% survival in interstitial lung disease [ILD]) [Figure 7] and [Figure 8].", "\n\nFigure 8: Apollo Heart and Lung Transplant Team with the oldest recipient of heart-lung transplant in India after an uneventful laparoscopic cholecystectomy 4 years post transplant under general anaesthesia\n\nHeart–lung and lung transplant in India is in its infancy with limited centers doing the procedure. ", "We have presented the experience of the Department of Heart and Lung Transplantation, Apollo Hospitals, Chennai, which has one among the largest numbers of lung transplants in India and has discussed the selection process for the recipient and the donor.", "\n\nRecipient aspects\n\nIndications for lung transplant\n\nThis section deals with indications for lung transplant,[6],[7] both general aspects and objective criteria that need to be met in different groups of lung disease (disease-specific indications).", "\n\n>80% chance of surviving 5 years from a medical perspective, provided the graft (transplanted lung) function is adequate.", "\n\nDisease-specific indications\n\nThese include specific objective criteria, in different lung diseases, which need to be present in order to consider lung transplantation.[8]\n\nInterstitial lung disease\n\nPatients are referred when there is interstitial pneumonitis or fibrosing nonspecific interstitial pneumonitis[8] with forced vital capacity <80% predicted, diffusing capacity of the lung for carbon monoxide <40% predicted, and desaturation to <88% on room air [Table 2].", "\n\nTreatment for pulmonary artery hypertension is largely medical with pulmonary vasodilators and transplantation is only indicated[8] when there is clinical deterioration in spite of maximal medical therapy [Table 5].", "\n\nThese conditions may preclude a transplant operation, and thus it is important that these conditions are looked for and treated before any decision to transplant.[6],[7],[10]\n\nAbsolute contraindications\n\nThe absolute contraindications which preclude lung transplantation are discussed below [Table 7]. ", "Every effort must be taken to ensure that these absolute contraindications are ruled out prior to listing for lung transplantation.", "\n\nMalignancy: Active current malignancy is an absolute contraindication. ", "In patients with treated malignancies in the past, the treatment must be deemed to have been curative with a disease-free period of 5 years, though in some malignancies a 2-year disease period is adequate.", "\n\nVasculitis screen in patients with suspicion of autoimmune disease or connective tissue disease.", "\n\nMiscellaneous tests\n\nBlood group – checked twice\n\nHuman leukocyte antigen tissue typing\n\nPanel reactive antibody (PRA) screen\n\nPap smear and mammograms in all female patients every year\n\nUrine analysis, 24-h creatinine clearance\n\nDuplex scan to rule out deep vein thrombosis\n\nArterial Doppler of the lower limbs in case of suspicion of peripheral vascular disease\n\nCarotid Doppler in patients with suspected vascular disease\n\nBone densitometry for patients with a history of steroid therapy\n\nDental clearance\n\nENT clearance, especially in patients with cystic fibrosis\n\nNephrology clearance\n\nEvaluation by psychiatrist and social worker.", "\n\nDonor aspects\n\nDonor selection is crucial, and it is pertinent to note that, among the donor pool only about 17%–20% of the lungs are usable as opposed to much higher rates of usable organs such as kidney, liver, and heart. ", "The ideal donor should have characteristics as listed below [Table 9].", "\n\nNormal bronchoscopy with minimal or no secretions and no organisms on Gram stain from bronchial lavage\n\nNo evidence of aspiration or sepsis\n\nNo prior thoracic surgery on the side of harvest.", "\n\nTransplant decision\n\nThis section discusses the decision-making process involved in recommending lung transplant to patients.[5]\n\nWhether transplant is appropriate?", "\n\nThe following three questions need to be considered by the physician/transplant team and only if the answer to each of these questions is “yes,” should a transplant be recommended.", "\n\nQ.1. ", "Has the disease reached end stage? (", "Disease point of view)\n\nQ.2. ", "Can the patient tolerate the operation? (", "Patient point of view)\n\nQ.3. ", "Have all contraindications been ruled out?", "\n\nDisease point of view\n\nIt is crucial that all nontransplant treatment options are tried/considered and found to be futile before decision to transplant.", "\n\nPatient point of view\n\nThe comprehensive assessment by the multidisciplinary team of specialists is important in evaluating each organ system and more importantly in ensuring that there are no absolute contraindications for transplant.", "\n\nTiming of transplant\n\nThe correct timing of transplant operation is a crucial factor which has a significant impact on outcomes.", "\n\nTransplant window\n\nIt is the ideal time period to consider the operation, wherein the lung has reached end stage, but all the other organ systems are well preserved. ", "Such patients do well.", "\n\nToo well for transplant\n\nConsidering transplant in a patient early on in the disease process, that is, before end-stage disease is hazardous. ", "This is because the risks to the patient from the transplant operation would be higher than the risk to the patient from the lung disease.", "\n\nToo sick for transplant\n\nOn the other hand, considering transplant in a patient who has advanced disease with multiorgan failure is inappropriate. ", "This is because the outcomes in the subgroup are often fatal. ", "Furthermore, donor organs are a scarce resource and should be used appropriately.", "\n\nDecision-making process\n\nTwo main risk assessment processes help in decision to register a patient for transplant.", "\n\nRisk–benefit analysis of transplant operation\n\nIf the anticipated are much higher than the possible risks, decision to consider transplant is made. ", "Conversely, if the risks are prohibitive in the face of very little benefit, the patient is strongly dissuaded from having a transplant.", "\n\nRisks with transplant versus risks without transplant\n\nThis is another important consideration which helps in decision-making. ", "If the risks from the disease, without transplant, is much higher than the risks involved in transplant operation, decision to consider transplant is made.", "\n\nBridging to lung transplant\n\nWhen patients, who are on the waitlist for transplant, suddenly deteriorate resulting in MV or institution of extracorporeal membrane oxygenation (ECMO), they may be considered for lung transplant.", "\n\nThus, MV and ECMO may be used to “bridge”-selected patients to successful lung transplant.[11],[12],[13],[14],[15],[16] Among our lung transplant patients, we have bridged one patient from ECMO and one patient from MV. ", "The outcome of lung transplant in patients who are bridged from MV or ECMO are acceptable, provided they are stable on MV or ECMO, before transplant.", "\n\nSituations specific to the India\n\nLate presentation of patients\n\nWe have observed quite uniformly that our patients, unlike in the West, present very late in the course of the disease.[5],[17] This is attributable to two factors – Patient factors and physician factors.", "\n\nPatient factors\n\nBy and large Indian patients often dread surgery and end up putting off their decision, until it is too late. ", "In some instances, religious beliefs regarding organ transplantation may deter acceptance to transplant operation even when they are “fit” for a transplant. ", "The inevitable clinical deterioration “forces” them to agree eventually, by which time they are bed bound with muscle wasting and result in stormy postoperative courses and lesser surgical outcomes.", "\n\nPhysician factors\n\nInitial reluctance of physicians to refer patients for transplant may be due to decreased awareness of availability of such a treatment option in India and the suboptimal surgical outcomes in patients who presented late. ", "Our increasing experience and standardizing protocols with improved results has, to an extent, overcome the reluctance and we now are seeing increasing referrals at appropriate time.", "\n\nEndemicity of tuberculosis\n\nTuberculosis (TB) is endemic in India and this impacts on both recipients and donors.[5]\n\nIn recipients: Special emphasis is to made during pretransplant workup to rule out TB. ", "We have, on one occasion, done mediastinoscopy under high-risk general anesthesia to sample mediastinal nodes and commenced antituberculous therapy after a positive histology report. ", "It is important to diagnose TB and treat appropriately before listing for transplant, in view of postoperative immunosuppression.", "\n\nIn donors: Subclinical TB needs to be excluded in donors before organ retrieval. ", "While the presence of normal chest X-ray with normal bronchoscopy rules out parenchymal pulmonary TB, mediastinal tuberculous lymphadenopathy is quite prevalent in India may be missed. ", "Perhaps, in our country, computed tomography scan of the chest needs to be considered, wherever feasible, as a part of evaluation of donor mediastinum.", "\n\nSome characteristics of favorable recipient (for the first case when starting a program) based on Indian experience\n\nAge <60 years\n\nAble to walk with oxygen supplement for at least 250 m with or without rest in 6 min\n\nPatients referred appropriately with no evidence of frailty, myopathy, or muscle weakness.", "\n\nRecipient with COPD would be an ideal first case from the surgical point of view compared to ILD\n\nSingle lung transplant has good early results, but lesser long-term survival\n\nDouble lung transplant has a difficult early period, but better long-term survival.", "\n\nConclusions\n\nFor a successful lung or heart–lung transplant, we need to choose carefully the correct recipient, the correct donor, have the transplant team in place and go ahead and be prepared for all the complication which can occur. ", "This would result in patients surviving more than 1 year and reaching a median survival equal to Western figures of 50% at 5 years." ]

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[ "The mismeasurement of sexual selection.", "\nSexual selection can explain major micro- and macro-evolutionary patterns. ", "Much of current theory predicts that the strength of sexual selection (i) is driven by the relative abundance of males and females prepared to mate (i.e. the operational sex ratio, OSR) and (ii) can be generally estimated by calculating intra-sexual variation in mating success (e.g. the opportunity for sexual selection, I(s)). ", "Here, we demonstrate the problematic nature of these predictions. ", "The OSR and I(s) only accurately predict sexual selection under a limited set of circumstances, and more specifically, only when mate monopolization is extremely strong. ", "If mate monopolization is not strong, using OSR or I(s) as proxies or measures of sexual selection is expected to produce spurious results that lead to the false conclusion that sexual selection is strong when it is actually weak. ", "These findings call into question the validity of empirical conclusions based on these measures of sexual selection." ]

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[ "Combining two or more drugs can be an effective treatment of diverse diseases, such as cancer. ", "Yet, at the same time, the wrong drug combination can cause major side effects. ", "Currently there is no systematic understanding of how different drugs influence each other. ", "Thus, elucidating how two given drugs interact, and whether they have a beneficial effect, would mean a major step towards drug development to treat diseases more effectively in the future.", "\n\nOn a molecular level, drugs cause complex perturbations of various cellular processes in our body. ", "These processes are orchestrated by an intricate network of molecular interactions, the so-called interactome. ", "Over the last decade, numerous studies have revealed a close relationship between the structure of the interactome and the functional organization of the molecular machinery within the cell. ", "This opened exciting opportunities for using network-based approaches to investigate the foundations of both healthy and disease states. ", "Following this trend, Principal Investigator Jörg Menche and his group at CeMM developed a novel mathematical framework for mapping out precisely how different perturbations of the interactome influence each other.", "\n\nThe new study performed by Caldera et al., ", "represents the first general approach to quantifying with precision how drugs interact with each other, based on a mathematical model that considers their high-dimensional effects. ", "Their research reveals that the position of targets of a given drug on the interactome is not random but rather localized within so-called drug modules. ", "They found that the location of a drug module is linked to the specific cell morphological changes induced by the respective treatments, making morphology screens a valuable resource for the investigation of drug interactions. ", "Further they identified various factors that contribute to the emergence of such interactions. ", "Most notably, the distance between two drug modules on the interactome plays a key role: Certain types of interactions are more likely depending on the exact proximity between the two respective drug modules. ", "If the modules are too far away from each other, it is rather unlikely that an interaction will take place.", "\n\n\"We developed a completely new methodology to classify drug interactions. ", "Previous methods could characterize interactions only as synergistic or antagonistic. ", "Our methodology is able to distinguish 12 distinct interactions types and also reveals the direction of an interaction,\" says Michael Caldera, first author of the study and PhD student at Jörg Menche's Group.", "\n\nThe study of the Menche group has broadened the understanding of how drugs perturb the human interactome, and what causes drugs to interact. ", "Moreover, the introduced methodology offers the first comprehensive and complete description of any potential outcome that may arise from combining two perturbations. ", "Finally, this methodology could also be applied to address other key challenges, such as dissecting the combined impact of genetic variations or predicting the effect of a drug on a particular disease phenotype. ", "Their research forms a solid base for understanding and developing more effective drug therapies in the future." ]

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[ "Vacuum Elevators. ", "Are going to install anelevator in your home or Office? ", "Forget about the concrete box, cables, pulleys or pistons. ", "Today we can move people to upper floors in pneumatic elevatorssuch as we saw in the old films of science fiction, where people were transported in one cristal capsule, without the aid of wires. ", "This extraordinary technology has made the future becomes reality.", "\n\nVacuum elevators are also known as pneumatic elevators. ", "These consist in the combination of a cylindrical stack with smooth inner surface and a coaxial cab to the vent that moves inside. ", "The vertical cylindrical duct is a self supporting structure, light and resistant polycarbonate.", "\n\nGeneral characteristics of the Vacuum Elevators:\n\nVacuum Elevators looks so high-tech and futuristic, making it a good addition to a modern residential building. ", "Plus, there is no need for cables, pulleys and pistons as this elevator only makes use of air pressure to function.", "\n\nThis kind of elevators contributes to theelimination of architectural barriers and facilitates accessibility with a touch of style and distinction. ", "Which means that it supports on itself so it does not require retaining wall.", "\n\nYou can set it directly on any existing floor and because of its weight, small size and lack of needing to pit, it is the ideal equipment to be installed in apartments, Lofts and in those places where the total weight of the equipment is a something to take into account.", "\n\nPneumatic Vacuum Elevators Advantages\n\nThere are many reasons why homeowners prefer getting a pneumatic elevator installed in their homes to other types of residential elevators.", "\n\n-They are Installed in the day (2-3 hours)\n-Does not require civil works, is self supporting and does not require excavation or machine room.", "\n-They can be set on any existing floor\n-Is an not-fixed installation, so it can be dismanteled and transferred easily.", "\n-It doesn’t locks in intermediate levels\n-They ensures absolute safety: In a power cut, the cabin descends automatically to immediate downstairs.", "\n-It is absolutely panoramic,allows 360 ° visibility\n-It has no cables or Pistons that impede vision\n-It requires no lubrication and maintenance is minimal\n-It does not consume energy during the descent, using the force of gravity\n-Extremely soft starting and breaking\n-Does not require additional finishing\n-Resolves the difficulties economic technician who presents any other elevators\n-Its light weight allows the installation of Duplex or Triplex indoor horizontal property." ]

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[ "Oak Grove Cemetery\n\nOak Grove Cemetery may refer to:\n\n Oak Grove Cemetery (Conway, Arkansas), listed on the NRHP in Conway, Arkansas\n Oak Grove Cemetery (Des Arc, Arkansas), listed on the National Register of Historic Places in Prairie County, Arkansas\n Oak Grove Cemetery (Jerseyville, Illinois)\n Oak Grove Cemetery (Fall River, Massachusetts), listed on the NRHP\n Oak Grove Cemetery (Falmouth, Massachusetts)\n Oak Grove Cemetery (Gloucester, Massachusetts), listed on the NRHP\n Oak Grove Cemetery (New Bedford, Massachusetts), listed on the NRHP\n\nSee also\n Oak Grove-Freedman's Cemetery, Salisbury, North Carolina, listed on the NRHP" ]

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[ "Background\n==========\n\nHCV exists as quasispecies (QS) in infected individuals, consisting of a predominant viral variant and related, yet genetically distinct minor variants \\[[@B1]\\]. ", "The study of HCV QS has historically focused on the hypervariable region 1 (HVR1) of the second envelope (E2) glycoprotein gene \\[[@B2],[@B3]\\], the most variable region of the HCV genome. ", "Early studies revealed that E2-HVR1 is a target of neutralizing antibodies \\[[@B4]-[@B10]\\]. ", "Immune pressure is thought to be chiefly responsible for the fixation of the mutations in this region of the E2 gene.", "\n\nHCV QS have been analyzed in many different patient cohorts. ", "HVR1 QS evolution may reflect progression of liver disease \\[[@B11]-[@B15]\\]. ", "HCV QS also reflect the outcome of acute HCV infection \\[[@B16]\\], and responses to antiviral therapy \\[[@B17]\\]. ", "More recent studies have investigated the effect of HCV/HIV co-infection on HCV QS dynamics \\[[@B18],[@B19]\\]. ", "In the current study, we analyzed 20 baseline samples from the HALT-C trial and 12 HCV-HIV co-infected patient samples. ", "The HALT-C study is a randomized multi-center clinical trial to assess the effects of long-term pegylated interferon-α (peg-IFN) therapy on the progression of liver fibrosis and development of decompensated liver disease in hepatitis C patients who are non-responders to prior pegylated IFN plus ribavirin therapy \\[[@B20],[@B21]\\].", "\n\nViral QS have been analyzed by many techniques. ", "Cloning and sequencing is the gold standard. ", "Electrophoretic mobility-based assays, including single strand conformation polymorphism analysis (SSCP) and heteroduplex mobility analysis (HMA) allow determination of HCV QS heterogeneity without the need for sequencing (reviewed in \\[[@B22]\\]). ", "HMA was originally described for analyzing the sequence heterogeneity of the envelope gene of human immunodeficiency virus (HIV) \\[[@B23],[@B24]\\]. ", "HMA involves hybridization of a radioactive probe generated from a QS variant to either heterogeneous PCR reaction products derived by direct PCR amplification from clinical specimens, or to homogeneous HVR1 sequences derived from cloned QS variants (clonal frequency analysis, CFA; \\[[@B25]\\]). ", "Hybridizations between the probe and various target sequences result in the formation of double stranded DNA molecules (heteroduplexes) that produce shifts when the hybrids are separated on non-denaturing polyacrylamide gels. ", "The shifts are determined by comparison to a homoduplex probe control (probe hybridized to itself). ", "The extent of the heteroduplex shift compared to the homoduplex control is proportional to the degree of sequence divergence between the two DNA molecules. ", "We have shown an excellent correlation between genetic diversity and complexity (number of variants) of individual QS variants derived by HMA as compared with standard cloning and sequencing of the HVR1 \\[[@B11]-[@B13],[@B25],[@B26]\\]. ", "Moreover, HMA can be applied to studies of HCV QS evolution, in the context of therapy, transmission, and pathogenesis \\[[@B11],[@B12],[@B25]-[@B29]\\].", "\n\nTaq polymerase is the enzyme used in most studies of HCV QS analysis. ", "However, given that Taq lacks proofreading activity, mathematical debates have been raised to suggest that QS evolution is overestimated by Taq induced mutations \\[[@B30]\\]. ", "Indeed, in one report, use of Taq increased the proportion of minor QS variants \\[[@B31]\\], and we have found that, in general, QS diversity is lower if proof-reading enzymes are used instead of Taq \\[[@B32]\\]. ", "But the question arises as to whether Taq induced mutations affect the outcomes/conclusions in cohort-based studies on HCV QS. ", "Thus, in the current study, we compared Taq and HF-2 polymerases in terms of sensitivity and robustness, and in terms of evaluating HCV QS diversity and complexity as assessed by CFA of the E2-HVR1 on baseline specimens from 20 patients in the HALT-C trial and 12 HCV-HIV co-infected patients receiving or not receiving HAART.", "\n\nResults\n=======\n\nClinical characteristics of the HALT-C and HCV-HIV co-infected patients are depicted in Tables [1](#T1){ref-type=\"table\"} and [2](#T2){ref-type=\"table\"}. ", "For HALT-C patients, all patients were infected with HCV genotype 1, with 10/20 (50%) being genotype 1a, and 7/20 (35%) being genotype 1b. ", "Subtype designations were not obtained for 2/20 (10%) genotype 1 patients, and 1 patient was designated as type 1a or 1b. ", "16/20 (80%) patients were male. ", "The average age of patients was 48.9 years, and average viral load was 10^6.56^IU/ml (3.6 × 10^6^IU/ml). ", "For the HCV/HIV co-infected patients, all patients were infected with HCV genotype 1, with 10/12 (83%) being genotype 1a, and 2/12 (17%) being genotype 1b. ", "Eight of 12 patients (67%) were male. ", "The average age of the co-infected patients was 44 years, and average viral load was 10^6.53^IU/ml (3.3 × 10^6^IU/ml).", "\n\n###### \n\nClinical and virological characteristics of the 20 HALT-C patients.", "\n\n Patient Age Gender Genotype Serum HCV RNA at W00 (log~10~) Diversity Complexity \n --------- ----------- -------- ---------- -------------------------------- ------------ ------------ --------- ---------\n Taq HF-2 Taq HF-2\n \n 1 52 M 1a 6.55 0.9953 1.0000 7 1\n 2 54 F 1b 6.49 0.9905 1.0000 5 1\n 3 51 M 1a/b 6.99 0.9958 1.0000 5 1\n 4 42 M 1a 6.81 0.9877 0.9894 6 2\n 5 56 M 1a 7.13 0.9979 1.0000 4 1\n 6 42 M 1 6.55 0.9903 0.9912 8 6\n 7 73 M 1b 6.78 0.9892 0.9877 7 5\n 8 45 M 1 6.37 0.9193 0.9805 7 6\n 9 53 M 1a 7.06 0.9954 1.0000 2 1\n 10 47 M 1b 6.35 0.9845 0.9994 4 3\n 11 19 M 1b 5.72 0.9964 0.9994 2 2\n 12 49 M 1a 7.06 0.9979 0.9986 3 3\n 13 42 F 1b 6.26 0.9993 0.9781 2 2\n 14 42 M 1a 7.30 0.9810 0.9685 8 9\n 15 61 M 1b 5.85 0.9858 0.9624 4 5\n 16 54 M 1b 6.93 0.9047 0.9409 6 9\n 17 45 F 1a 6.72 0.9962 0.9917 2 5\n 18 47 F 1a 6.14 0.9966 0.9984 4 2\n 19 50 M 1a 6.37 0.9962 0.9968 4 3\n 20 53 M 1a 5.81 0.989 0.9943 6 5\n **AVG** **48.85** **6.56** **0.9845** **0.9889** **4.8** **3.6**\n\nHCV genotypes were determined by INNO-LiPA. ", "HCV RNA was quantified with the Roche COBAS Monitor assay, and is expressed as log~10~IU/mL. QS heterogeneity was assessed using the clonal frequency analysis (CFA) technique. ", "Diversity scores represent the average heteroduplex mobility ratios (HMR) for either Taq or HF-2 enzymes. ", "Complexity scores represent the total number of distinct gel shift variants analyzed by CFA. ", "W00 represents the week 0 or baseline sample. ", "AVG represents average.", "\n\n###### \n\nClinical and virological characteristics of the 12 HCV/HIV co-infected patients.", "\n\n Patient Age Gender Genotype Serum HCV RNA (log~10~) Diversity Complexity \n --------- ---------- -------- ---------- ------------------------- ------------ ------------ ---------- ---------\n Taq HF-2 Taq HF-2\n \n 1 49 F 1a 6.37 0.9856 0.9616 4 5\n 2 40 M 1a 5.96 0.9987 0.9978 2 2\n 3 36 F 1b 5.53 1.0000 1.0000 1 1\n 4 38 M 1a 6.75 0.9313 0.9715 8 11\n 5 42 M 1a 6.94 1.0000 1.0000 1 1\n 6 40 M 1b 5.55 0.9912 0.9997 5 2\n 7 41 M 1a 6.39 0.9909 1.0000 6 1\n 8 45 F 1a 6.25 0.9856 0.9468 4 7\n 9 47 M 1a 5.68 0.9945 0.9996 2 2\n 10 41 M 1a 5.92 0.9575 0.9430 10 10\n 11 61 F 1a 6.83 0.9389 0.9283 7 6\n 12 51 M 1a 6.99 0.9890 0.9638 2 7\n **AVG** **44.2** **6.53** **0.9803** **0.9760** **4.33** **5.0**\n\nHCV genotypes were determined by INNO-LiPA, while HCV RNA was quantified with the Roche COBAS Monitor assay, and is expressed a log~10~IU/mL. QS heterogeneity was assessed using the clonal frequency analysis (CFA) technique. ", "Diversity scores represent the average heteroduplex mobility ratios (HMR) for either Taq or HF-2 enzymes. ", "Complexity scores represent the total number of distinct gel shift variants analyzed by CFA. ", "AVG represents average.", "\n\nFigure [1](#F1){ref-type=\"fig\"} presents the sensitivity of the E2-HVR1 PCR using Taq versus HF-2 polymerases. ", "Serial dilutions of the HCV international standard were run through the assay, and PCR products were visualized on agarose gels. ", "As shown in Fig. [", "1](#F1){ref-type=\"fig\"}, Taq produced amplification products at all dilutions, with 1 of 2 duplicate samples giving a signal at a dilution of 50 IU/ml. ", "However, the HF-2 enzyme produced more PCR product than Taq at all dilutions and both replicates were positive at 50 IU/ml. ", "Below each lane is the result of Roche COBAS Amplicor qualitative RT-PCR testing of the same serum specimens, which are scored as positive (+) or negative (-). ", "At 50 IU/ml the Amplicor test was positive for 1 of the 2 duplicates. ", "The data indicate that the sensitivities of the Taq and HF-2 enzymes were similar to the Amplicor assay, and the HF-2 enzyme was slightly more robust and sensitive than Taq polymerase.", "\n\n{#F1}\n\nThe 2 enzymes produced QS diversity and complexity scores that were correlated (Linear regression analysis: R-squared: 0.4113, p \\< 0.0001 for diversity, and R-squared: 0.311, p \\< 0.001 for complexity; Spearman\\'s rank correlation test: r= 0.68, p \\< 0.0001 for diversity, and r = 0.47, p \\< 0.01 for complexity). ", "Figure [2](#F2){ref-type=\"fig\"} depicts representative clonal frequency analyses (CFA) of HALT-C baseline samples from patient 9 (figure [2A](#F2){ref-type=\"fig\"}), patient 6 (figure [2B](#F2){ref-type=\"fig\"}) and patient 16 (figure [2C](#F2){ref-type=\"fig\"}), amplified by both Taq and HF-2 enzymes. ", "The first lane of each gel represents the homoduplex probe control, obtained by hybridizing the radiolabeled probe to its non-labeled self. ", "The homoduplex (designated as \\\"HD\\\" in the figure) serves as the reference point for all comparisons of individual clonal gel shift patterns. ", "The second lane of each gel represents the heterogenous (ie non-clonal) PCR product, which contains all the QS variants amplified from the serum sample, and is designated as \\\"H\\\" in the figure. ", "For each CFA, a shift control is also included, which involves the hybridization of the probe hybridized to a different HVR1 PCR product. ", "In all cases, shift controls produced clearly identifiable shifts, indicating the hybridization reaction and electrophoresis was successful (data not shown). ", "An internal control is also derived from a comparison of the heterogenous PCR product (\\\"H\\\") versus CFA gel shift patterns. ", "If the gel shift patterns of the individual clones are representative of the heterogenous PCR product, the CFA was successful \\[[@B11],[@B26],[@B27]\\].", "\n\n{#F2}\n\nAs shown in Figure [2A](#F2){ref-type=\"fig\"}, patient 9 had very few discernible gel shifts, and the shifts themselves were not very distinct from the homoduplex probe control. ", "The same pattern was observed when either Taq or HF-2 was used. ", "Indeed, HMR scores for Taq and HF-2 (0.9954 vs. 1.0000) were similar, as were the complexity scores for samples analyzed by Taq and HF-2 (2 vs.1 variants). ", "The flat line nature of the CFA pattern was not due to a failure of the hybridization reaction, because the shift control (the same probe hybridized to a different HVR1 PCR product) produced a significant gel shift (data not shown). ", "Moreover, the same pattern was observed when the heterogenous PCR product (prior to cloning) was hybridized to the probe (Figure [2A](#F2){ref-type=\"fig\"}, lane 2). ", "The results indicate that this patient had minimal QS heterogeneity. ", "In contrast, patient 6 had clearly identifiable gel shifts when compared to the probe (Figure [2B](#F2){ref-type=\"fig\"}). ", "The same pattern was observed whether the reaction was performed with Taq or HF-2 enzyme. ", "Again, Taq and HF-2 scores were similar both for HMR (0.9903 vs 0.9912 (Taq vs. HF-2)) and complexity (8 vs. 6 variants (Taq vs. HF-2)). ", "The gel shift pattern observed with CFA was similar to the pattern observed when heterogenous PCR product from the same time point was hybridized to the probe (Figure [2B](#F2){ref-type=\"fig\"}, lane 2). ", "Patient 16 displayed even more marked QS heterogeneity (Figure [2C](#F2){ref-type=\"fig\"}). ", "This was quantitated both in terms of HMR (0.9047 vs. 0.9409 (Taq vs. HF-2)) and complexity (6 vs. 9 variants, (Taq vs. HF-2)). ", "The bar graphs in Figures [2D](#F2){ref-type=\"fig\"} and [2E](#F2){ref-type=\"fig\"} summarize the diversity (HMR) and complexity data, and confirm the progressively increasing QS diversity and complexity in patients 9, 6, and 16. ", "Note that increased QS diversity is reflected as a decrease in HMR.", "\n\nFurthermore, Taq gave lower HMRs indicative of higher diversity in all 3 patients, and higher complexity scores in 2 of the 3 patients. ", "The data suggest that Taq may overestimate HCV QS genetic diversity and complexity when analyzed by HMA.", "\n\nTo further examine this issue, CFA was performed for 20 HALT-C baseline specimens, and QS diversity scores and complexity scores were determined. ", "These data are summarized in Table [1](#T1){ref-type=\"table\"} and depicted graphically in Figure [3](#F3){ref-type=\"fig\"}. ", "Figure [3A](#F3){ref-type=\"fig\"} depicts the HMR results, while Figure [3B](#F3){ref-type=\"fig\"} depicts the complexity scores for the 20 HALT-C patients analyzed by both enzymes. ", "The average HMR for Taq amplified samples was 0.9845 (range 0.9047--0.9993), while the average HMR for the HF-2 enzyme was 0.9889 (range 0.9407--1.000). ", "Taq samples appeared somewhat more diverse than HF-2 samples. ", "However, this trend did not reach statistical significance (p = 0.126). ", "Similarly, the average complexity for Taq amplified samples was 4.8 (range 2--8), while the average complexity for the HF-2 enzyme was 3.6 (range 1--9). ", "QS complexity scores were higher in samples amplified by Taq as compared with samples amplified by HF-2 (p = 0.033).", "\n\n{#F3}\n\nCumulatively, the data indicate that Taq overestimates HCV QS genetic diversity and complexity. ", "However, what is not clear is whether this tendency for overestimation by Taq impacts QS scores in clinical studies.", "\n\nTo address this issue, we grouped the 20 HALT-C patients according to whether they were serum positive or negative for HCV RNA following 20 weeks of pegylated IFN plus ribavirin therapy. ", "By this criterion, 6 patients were HCV RNA negative and 14 patients were HCV RNA positive at week 20. ", "Figure [4](#F4){ref-type=\"fig\"} presents the HMR and complexity scores for the 2 groups of patients and demonstrates that HMR and complexity scores were similar among patients who were HCV RNA negative or positive following 20 weeks of peg-IFN plus ribavirin, regardless of the enzyme used. ", "There was a trend for HF-2 samples generating lower complexity scores as compared to Taq samples, but the difference was not significant. ", "Note also that the lower complexity scores from HF-2 as compared with Taq processed samples among week 20 responders and non-responders mirrored the results when all patients were considered together (Figure [3](#F3){ref-type=\"fig\"}).", "\n\n{#F4}\n\nTo further determine if the choice of amplification enzyme affects results in patient cohort studies, we compared QS diversity and complexity on samples from 12 HCV/HIV co-infected patients treated or not treated with highly active anti-retroviral therapy (HAART). ", "As shown in Figure [5](#F5){ref-type=\"fig\"}, patients receiving HAART had increased QS diversity (shown as a decrease in HMR in panel A) and complexity (panel B) as compared to patients who did not receive HAART. ", "This trend was apparent regardless of whether Taq and HF-2 were used. ", "The increase in diversity and complexity scores upon HAART did not reach statistical significance. ", "Moreover, HMR and complexity scores were not significantly different between Taq and HF-2 samples. ", "In fact, HAART-samples amplified by HF-2 showed a trend for higher complexity scores (complexity = 4) as compared with Taq samples (complexity = 3.2). ", "These data suggest that although Taq may overestimate QS complexity, it likely does not mask potentially important clinical associations when HCV QS are analyzed by HMA.", "\n\n{#F5}\n\nDiscussion\n==========\n\nIn the current investigation, we found that the sensitivity of Taq and HF-2 enzymes in amplifying the E2-HVR1 were similar to the qualitative Roche COBAS Amplicor RT-PCR assay. ", "The HF-2 enzyme generated more PCR product and was more sensitive than Taq. ", "For HALT-C samples, QS diversity, expressed as an HMR, was similar for both Taq and HF-2 enzymes, although Taq tended to give higher diversity scores. ", "HCV QS complexity was significantly higher in samples amplified by Taq as compared with samples amplified by HF-2. ", "In contrast, in HCV/HIV co-infected samples, diversity and complexity scores were similar for both enzymes. ", "The data from this limited cohort suggest that QS results are not significantly influenced by choice of polymerase when using the CFA method.", "\n\nOur data indicate that Taq induced errors provide inflated estimates of HCV QS diversity and complexity. ", "The data are in accord with previous mathematical models of HCV QS mutations \\[[@B30]\\], and a recent study that demonstrated that Taq induced errors can generate minor QS variants \\[[@B31]\\]. ", "However, our results showed only a trend for increased HMR for Taq amplified HALT-C samples as well as for HMR and complexity scores for HCV/HIV co-infected samples. ", "Based on the current results, it would seem that Taq and proof-reading enzymes are acceptable for HCV QS analyzed by CFA. ", "However, further studies on larger patient cohorts need to be performed.", "\n\nGenetic evolution in the E2-HVR1 is believed to reflect selective forces imposed on this domain by neutralizing antibodies \\[[@B4]-[@B10]\\]. ", "It is also possible that cell mediated immune responses may impart selective pressures on HVR1. ", "In the face of immune pressure, the plasticity of the HVR1 may allow the virus to persist. ", "However, recent studies suggest that the HVR1, although it is the most variable region in the HCV genome, has certain constraints in its structure. ", "It is intriguing that key basic residues are highly conserved, which maintains the chemicophysical properties and conformation of the HVR1 \\[[@B33]\\]. ", "Because HVR1 is an exposed domain on the E2 protein, these data suggest that the positively charged HVR1 is involved in interactions with negatively charged molecules such as lipids, proteins, or glycosaminoglycans (GAGs). ", "As such, the HVR1 may interact with GAGs facilitating host cell recognition and attachment \\[[@B33]\\]. ", "In this regard, it has recently been shown that high pretreatment HCV QS diversity and complexity at baseline are associated with non-response to pegylated IFN ribavirin in HALT-C patients \\[[@B34]\\].", "\n\nHAART therapy appeared to increase HCV QS diversity and complexity, regardless of the enzyme used, but this did not reach statistical signficance in this small cohort. ", "These data are consistent with recent reports that suggest that HAART-induced immune reconstitution drives HCV QS evolution \\[[@B18],[@B19]\\]. ", "Additional prospective trials on larger patient cohorts are required to further examine the relationships between immune pressure, HCV QS evolution, and liver disease progression in patients co-infected with HIV and HCV.", "\n\nMaterials and methods\n=====================\n\nPatients\n--------\n\nTwenty patients who met entry criteria for the HALT-C trial were included in the current study. ", "Serum samples from baseline (week 0; (W00)), prior to the start of IFN therapy, were analyzed. ", "Written, informed consent was provided by all patients, following institutional and trial specified IRB regulations. ", "The design and conduct of the HALT-C trial have been described \\[[@B21]\\]. ", "Briefly, in the initial or lead-in course of therapy, all patients are treated with pegylated interferon (Pegasys, Roche) plus ribavirin for a period of 24 weeks, with virologic assessment at 20 weeks to assess whether or not they are virological responders. ", "Patients who are responders at week 20 continue treatment and receive a full course of 48 weeks of therapy. ", "Those who remain HCV-positive in serum at 20 weeks are randomized to receive either continued low-dose pegylated interferon (without further ribavirin) or no further treatment beyond careful observation for the ensuing 3.5 years. ", "Immunology and virology ancillary studies including QS analysis are aimed at increasing our understanding of the complex interactions of virus and host in this debilitating and widespread disease \\[[@B34]\\].", "\n\nSamples from twelve patients co-infected with HCV and HIV were also analyzed. ", "Seven of these patients received HAART, while 5 patients did not. ", "All 32 patients were infected with HCV of genotype 1.", "\n\nE2-HVR1 RT-PCR Amplification and Cloning\n----------------------------------------\n\nHCV RNA was extracted from 100 μL of patient sera using HCV RNA isolation columns (Qiagen). ", "RNA was resuspended in DEPC-treated water, and converted into cDNA using oligonucleotide primers and AMV reverse transcriptase, as described previously \\[[@B26]\\]. ", "The same cDNA sample was then amplified using either Taq (Perkin Elmer, Wellesley, MA) or Advantage High Fidelity 2 (HF-2) (Clontech; Mountain View, CA) polymerases, using a nested PCR reaction as described \\[[@B26]\\]. ", "To provide a hot start, AmpliWax (Perkin Elmer) beads were used to separate Taq enzyme and primers, whereas the HF-2 enzyme mixture contains an anti-Taq antibody. ", "The primers generated the expected second round product of 176 base pairs. ", "PCR products were excised and purified with the QiaEx purification system (Qiagen, Valencia, CA), ligated into pCR2 vector, and transformed into TOP10 cells as described \\[[@B11]\\].", "\n\nSensitivity of E2-HVR1 PCR Assay\n--------------------------------\n\nTo determine the sensitivity of the E2-HVR1 PCR assay using Taq versus HF-2 polymerases, serial dilutions of an HCV World Health Organization (WHO) international standard \\[[@B35]\\] were prepared from 50,000 to 50 International Units/milliliter (IU/ml). ", "RNA was extracted, converted into cDNA and amplified by nested PCR as described above. ", "PCR products were separated on agarose gels. ", "Aliquots of WHO standards were also run through the Roche Amplicor assay for internal comparison.", "\n\nHCV RNA quantitation and genotyping\n-----------------------------------\n\nHCV RNA was qualitatively measured by RT-PCR using the Roche COBAS Amplicor HCV test version 2.0 (RocheMolecular Systems, Branchburg, NJ), and quantitatively using Roche COBAS Amplicor HCV Monitor v. 2.0 (Roche Molecular Systems, Branchburg, NJ). ", "Genotyping was performed using the INNO-LiPA HCV II Kit (Bayer Diagnostics, Emeryville, CA) All assays were performed according to manufacturer\\'s specifications.", "\n\nClonal Frequency Analysis (CFA)\n-------------------------------\n\nFor each cloned HVR1 PCR product, 20 colonies were picked directly into tubes for re-amplification of the second round PCR product. ", "Thus, for each patient, 20 PCR products representing 20 individual QS clones derived from the baseline serum were analyzed. ", "PCR products were visualized on ethidium bromide-stained agarose gels, and one HVR1 PCR product was randomly selected, purified as described above, and end-labeled with ^32^P ATP and T4 polynucleotide kinase. ", "Unincorporated label was separated with Centrisep columns (Princeton Separations, Adelphia, NJ), and the labeled DNA probe was eluted from the column. ", "Labeled probe was hybridized directly to each amplified PCR product for 2 hours at 55°C as described \\[[@B11]\\]. ", "Hybrids were separated on 6% non-denaturing polyacrylamide MDE gels (Cambrex, Baltimore, MD) and visualized by autoradiography as described \\[[@B11]\\].", "\n\nData Analysis\n-------------\n\nQS complexity was determined by counting the total number of unique gel shift patterns. ", "QS genetic diversity was determined by deriving the average heteroduplex mobility of all clones relative to the homoduplex probe control. ", "A heteroduplex mobility ratio (HMR) was calculated by dividing the distance in millimeters (mm) from the origin of the gel to the heteroduplex by the distance in mm from the origin to the homoduplex control. ", "In cases where both strands of the heteroduplex were clearly distinguishable, the average of the distance of each strand of the heteroduplex was used to calculate heteroduplex mobility \\[[@B25]\\]. ", "The HMRs for all variants in the population were averaged to provide the final HMR value. ", "Non-parametric Wilcoxon Signed Ranks tests were used to compare the differences in QS complexity and diversity scores between the different enzymes. ", "Linear regression analysis and Spearman\\'s rank correlation tests were also used to determine the correlation of Taq and Ad-HF2 measurements of QS diversity and complexity.", "\n\nAcknowledgements\n================\n\nThis is publication number 9 from the HALT-C Trial Group. ", "Financial support: This study was supported by the National Institute of Diabetes & Digestive & Kidney Diseases and the National Institute of Allergy and Infectious Diseases under contract numbers N01 DK92318, DK92319, DK92321, DK92324, DK92325, DK92326, and DK92328, with supplemental funds from the National Cancer Institute, the National Center for Minority Health and Health Disparities and by General Clinical Research Center grants from the National Center for Research Resources, National Institutes of Health (grant numbers M01 RR00043, RR00633, RR06192). ", "Additional funding to conduct this study was provided by Roche Laboratories, Inc.\n\nAuthors with no financial relationships to disclose are: SJP, DGS, MAA, JYD, and CM. ", "Financial relationships of authors with Roche Laboratories/Hoffmann-La Roche, Inc., are as follows: MCS is a consultant and speaker\\'s bureau member; KLL is a consultant and receives research support; HLB is a consultant, speaker\\'s bureau member, and receives research support; AMDB is a consultant, speaker\\'s bureau member, and receives research support; WML is a speaker\\'s bureau member and receives research support; and DRG receives educational grant support.", "\n\nThe authors gratefully acknowledge the HALT-C study investigators, research staff, and participants. ", "The members of the HALT-C Trial Group who contributed to the performance of the clinical study are: Dawn Bombard, RN; Minjun Chung; Maureen Cormier, NP-C; Nicole Crowder, LVN; Michael Doherty, MS; Rivka Elbein, RN; Donna Giansiracusa, RN, BSN; Carol B. Jones, RN; Michelle Kelley, ANP; Debra King, RN; Rachel Life, BS; Peter F. Malet, MD; Savant Mehta, MD; Susan L. Milstein, RN; Patricia Osmack; Amanda Reeck; Marisol Serrano; Rohit Shankar; Judy Thompson, RN; and Elizabeth Wright, PhD.\n" ]

{ "pile_set_name": "PubMed Central" }

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[ "Progress toward the development of agents to modulate the cell cycle.", "\nWith taxanes continuing to prove useful in the clinical treatment of cancer, the next generation of antimitotic agents has entered clinical trials. ", "Other mechanisms awaiting proof-of-concept for the treatment of antiproliferative diseases include inhibition of cyclin-dependent kinases (Cdks). ", "Flavopiridol and UCN-01 are continuing in clinical trials, and newer more selective Cdk inhibitors are now entering clinical evaluation." ]

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[ "January 31, 2007 — jao\n\nIt all began while i was using MDK‘s development as an excuse to learn everything i could about programming and programming tools: makefiles, autoconf, automake, localization, texinfo docs, lexers, parsers… and, eventually, extensibility. ", "I kept hearing about an exotic thing by the name of GNU’s Ubiquitous Intelligent Language for Extensions, and, finally, rose to the bait. ", "But my first attempts at writing Scheme felt awkward. ", "Not because of the parens (i liked Scheme syntax from day zero), but basically because i was writing C code using Scheme. ", "Clearly, i needed to read a bit about this new thing and, to that end, i got a copy of The Little Schemer… to no avail: i didn’t get what elephants, food and Socrates had to do with programming; i still felt awkward. (", "It was not the book’s fault, mind you, but mine. ", "More about this in a bit.)", "\n\nThen i found the book. ", "Abelson and Sussman’s Structure and Interpretation of Computer Programs changed my life as a programmer. ", "I’m sure you’ve read lots of praise for this book. ", "Totally deserved! ", "SICP is not really about Scheme, but about thinking about programming. ", "Reading it will make you a better programmer in any language. ", "It will expand your mind. ", "It will cure your diseases. ", "It’s really that good. ", "Besides, SICP is freely available in HTML, PDF and texinfo formats, so you really have no excuse. ", "For extra fun, get the accompanying video lectures, by Abelson and Sussman themselves. ", "These lectures are charming: these guys have a passion for what they do, and they transmit it from the very beginning, when Abelson jokingly explains why computer science is neither a science nor about computers.", "\n\nThe most cited alternative to SICP is How to Design Programs by Felleisen, Findler, Flatt and Krishnamurthi. ", "Its authors have even published a rationale, The Structure and Interpretation of the Computer Science Curriculum, on why they think SICP is not well suited to teaching programming and how their book tries to fix the problems they’ve observed. ", "I won’t try to argue against such eminent schemers, but, frankly, my feeling is that HtDP is a far, far cry from SICP. ", "HtDP almost made me yawn, and there’s no magic to be seen. ", "If for whatever reason SICP is not your cup of tea, i would recommend Max Hailperin‘s Concrete Abstractions as a far better (as in more fun than HtDP) alternative.", "\n\nWith SICP under my belt, i was ready for The Little Schemer and The Seasoned Schemer(by Daniel P. Friedman and Matthias Felleisen), which i read in a row. ", "You’d be hard pressed to find any programming book similar to the Schemers books. ", "As in my case, the initial reaction may well be of rejection: on a superficial reading they look too queer, even childish, and by any means the kind of book a serious programmer should read, except maybe for fun. ", "But that’s precisely the point: you won’t learn unless it is for fun! ", "If you enter the game proposed by Daniel and Matthias, accepting to participate in their Socratic scheme, you’ll learn a lot with their books. ", "I found easier to put me in the right mood after SICP because it also is imbued of a kind of magic, and also because i was much better equipped to capture the subtleties lurking in every page of the Schemers books. ", "Besides having a great time, one ends up with a sound grasp of higher order functions, recursion (including the Y combinator) and continuations. ", "In fact, it was reading The Seasoned Schemer that something clicked and i really understood continuations.", "\n\nAfter all these readings i felt i was starting to have a good grasp of the conceptual underpinnings of Scheme and Lisp, and that it was due time to strengthen the technical details. ", "Or in other words, i wanted to come to grips with the nitty gritty details of Scheme syntax and semantics, including macros (which i knew from some tutorials and readings on Common Lisp). ", "To that end, Dybvig‘s The Scheme Programming Language was the perfect book. ", "Comprehensible, exacting and with an elegant prose, and to the point. ", "But, despite its succinctness, Dybvig does an excellent job in conveying the details of the language and its usage. ", "The book also includes extended usage examples for a good measure. ", "Thus, TSPL works nicely as both a tutorial and a handy reference.", "\n\nIf you already have a good basis on functional programming you can use TSPL as your first Scheme book and skip the previous ones (but you will be skipping lots of fun and, maybe, insight too). ", "And if you happen to read French, an interesting alternative for a speedier learning path is Jacques Chazarain’a Programmer avec Scheme. ", "In the first part of the book, Practical programming with Scheme, Scheme is thoroughly presented, using it in many examples taken from the standard data structures and algorithms curriculum. ", "Taking this practical basis as a starting point, Chazarain proceeds to a comprehensive (almost 400 pages long) discussion of the formal basis of the theory of programming languages: automata, lexers and parsers, propositional calculus, rewriting systems, logic programming, lambda calculus and more. ", "As you can see, the scope of this book is amazing, and it’s well worth learning a little French!", "\n\nThe nice thing about learning a programming language in such a good company is that one learns much more than a single programming language. ", "These books helped me obtain a conceptual basis for thinking about programming and programming languages in abstract terms, applicable to any programming problem. ", "As Sussman colorfully demonstrates in one of the SICP lectures, one feels like beholding the heart of the spirit that lives in the machine. ", "An that spirit, of course, is an interpreter. ", "So i delved into the theory and practice of implementing interpreters guided by another classic: Essentials of Programming Languages by Daniel P. Friedman, Mitchell Wand, and Christopher T. Haynes. ", "This marvelous book delves deep into the art of writing interpreters using Scheme as the implementation language. ", "By way of running example, an interpreter for an ML-like language is developed all along, showing the magic of, among other things, register machines or continuation-passing style. ", "To get a flavor of what this book has to offer, i wholeheartedly recommend reading Friedman’s The Role of the Study of Programming Languages in the Education of a Programmer, an insightful talk on how a theoretical background is useful (and even needed) to any programmer in any language, which Friedman illustrates with practical cases taken from his book.", "\n\nOne of the rites of passage of any self-deserving schemer is writing a metacircular scheme interpreter, that is, a scheme implemented in itself. ", "Having a look at the innards of your language implementation sheds a whole new light on your daily usage of the language. ", "Sussman goes as far as wearing his magician’s hat when he explains the metacircular interpreter in the SICP lectures, and rightly so. ", "But i’ve always felt a bit frustrated by the fact that the implementations one finds in books like SICP, EOPL or, to cite another classical example, PAIP are actually for toy interpreters not covering all the details of real Schemes. ", "And often the left out precisely the most interesting bits! ", "Fortunately, there’s a book that will tell you everything you ever wanted to know about implementing Lisp interpreters and compilers: Lisp in Small Pieces by Christian Queinnec. ", "This is easily the best book about Lisp i have ever read. ", "LiSP shows, without omitting any details, how the family of Lisp languages is implemented (in interpreted and compiled forms). ", "You’ll learn from the inside the difference between Lisp-1 and Lisp-2, how dynamical and lexical scope work, how blocks and continuations are related, how on earth one implements… everything you ever wanted to know about Lisp implementations, and then more. ", "On top of that, Queinnec writing style is engaging and the book is pervaded by a fine sense of humour that made me laugh out loud several times. ", "If you’re serious about Lisp, you must read this book.", "\n\nLet me close my list of recommendations with the last addition to my Scheme bookshelf, namely, the third schemer installment: The Reasoned Schemer (by Daniel P. Friedman, William E. Byrd, Oleg Kiselyov). ", "Paraphrasing Alan Perlis, the key reason for learning new languages and paradigms is the fact that they, hopefully, change the way you think about programming. ", "Functional languages do a pretty good job at that, but they’re not the only game in town. ", "Declarative programming is definitely another mind blowing experience, which you can enjoy reading The Reasoned Schemer. ", "The book presents, in that peculiar style of its predecessors that i like so much, the basis of logic programming using a Scheme implementation that, in many ways, surpasses standard declarative languages like Prolog. ", "The best of two awesome worlds, and an excellent way to ensure that you keep learning and expanding your programming horizons.", "\n\nHappy reading!" ]

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[ "Looking for Bass Tips\n\nI have little formal training. ", "I did an intro package lesson that consisted of very basic learning. ", "I did buy two books; Hal Leonard Bass Method complete edition and Rock House Bass method. ", "I am wanting to expand and learn more, however I am not sure where I should go from here, I am wanting to get the foundations down. ", "Right now I know enough to be dangerous. ", "I was looking at more live lessons, however I am also looking at stuff online also (Fender Play, etc.).", "\n\n1.Learn the major and minor pentatonic scales for bass.", "\n2.Practice them until your fingertips bleed.", "\n3. ", "Practice them every concievable pattern and to the point you can play them while holding a converation with someone and not even think about where to put your fingers.", "\n4. ", "Practice them even more.", "\n\n99.9% of everything you will ever want to play will be the major and minor pentatonic scale.", "\n\nWhen you get bored of playing them so much , go back and find ways of unbording yourself and learning even more ways to play them.", "\nYou will eventually want to learn \"walking basslines\" but that will do no good if you dont know what to play when you are not \"walking\" so LEARN this first.", "\n\nGoogle \" minor pentatonic scale for bass\" and learn the patterns for every musical key.", "\n\nBelow is the MAJOR pentatonic for the Key of C and The Key of B. (The minor version is the same but includes some additional notes)\nNotice the patterns? ", "Notice if you change from B to the key of C what happens to your scale on the fretboard? ", "Do the notes move up or down a fret but the pattern remains the same otherwise? ", "What do you suppose happens when you want to play past the 12th fret? ", "Maybe the pattern starts over again?", "\n\nThe main area in the Key of B will be the pattern around the 7th fret. ", "The main area of the Key of C will be the pattern around the 8th fret.", "\n\nKnow this scale and how to slide it up and down the frets until you dont have to even think about it. ", "Everything will come down to the major or minor pentatonic scales.", "\n\nUntil you know those two...the MAJOR and the MINOR pentatonic...you're spinning wheels and getting distracted away from the basics.", "\n\nYou want to play bass? ", "You need to find the\"groove\" so even practicing two notes, find ways of playing those two notes rhythmically and find ways to make a \"groove out of just those two notes....10 different ways.", "\n\nFinally ....watch this. ", "It will make you want to give up playing and throw your bass in the garbage.. This guy is insane BUT ...hes just playing the minor pentatonic:\n\n[youtube]CFmELh_Kjno[/youtube]\n\nIts so easy even a grandma can do it...\n\n[youtube]WMznvEgOPhU[/youtube]\nEdited by LittleWing on January 03 2019 07:06\n\nWell I'm a drummer (and occasional guitar player), but I lived with a bass player for years, and hung out with a few...and I recommend watching any of Scott Devine lessons on youtube, as theres quite a few and he is a highly rated player and teacher. ", "I met him at the London Bass Show, a really top bloke.", "\n\nAlso look out for used bass dvds on ebay, I've bought a pile of drumming dvds and they are worth every penny, when you think of what you are learning for what is about a tenner!", "\n\nLastly, chat to the people on here, there are many wonderful players who are very helpful too.", "\n\nLeebo wrote:\nI have little formal training. ", "I did an intro package lesson that consisted of very basic learning. ", "I did buy two books; Hal Leonard Bass Method complete edition and Rock House Bass method. ", "I am wanting to expand and learn more, however I am not sure where I should go from here, I am wanting to get the foundations down. ", "Right now I know enough to be dangerous. ", "I was looking at more live lessons, however I am also looking at stuff online also (Fender Play, etc.).", "\n\nHi Leebo,\n\nhappy new year, and welcome to Wikiloops :)\n\nIf you can, get more lessons with a good teacher. ", "He/she will correct your posture and everything before any bad habits creep in (it's hard to get rid of them later).", "\n\nAnd self study with books or online lessons is good, but it will miss that corrective part which is important in the beginning IMHO.", "\n\nBut the best advice I can give is just to play - and you found the right spot to get more than enough \"training material\". ", "It helps if you don't concentrate on just one style (like Rock), but to try each and every one. ", "If you can also play live with others, do that - but this platform really is the next best thing to that. ", "Ask for critique if you want/dare, and some will try to help in a constructive way.", "\n\nLittleWing wrote:Its so easy even a grandma can do it...\n\nHehe that was a good one, LW - and for Leebo, in case you don't know Carol Kaye - she's one of the best session players in the history of the bass right after James Jamerson. ", "If you search for them you'll find many good tracks and \"must learn\" lessons.", "\n\nOh, and yes, listening to others is also always helpful. ", "I just listened to \"Out Here\" from the Christian McBride Trio - a monster player. ", "And even here you'll find many good and helpful players, so if in doubt, just ask.", "\n\nAgain, welcome - good to have you here :)\n\nCheers,\nWolfgang\n\nEdit: just listened to your first two uploads, cool man! ", "But since you asked for tips, try to use a compressor on your bass, a search like https://duckduckgo.com/?q=reaper+compressor&t=ffnt&ia=videos will get you started for your DAW and the tools it has already. ", "More tips, partly, in the comments of your uploads.", "\n\nFirst of all happy New year and welcome aboard.", "\nI don't deny the aspect of a good foundation on scale and chords because I didn't. ", "So I do believe it can be a big help to make quicker progress on which notes are playable in which chords, but...\nDoes that mean the other notes are wrong? ", "No, depending on where you use them. ", "I sometimes say that I can only memorize the chromatic scale LOL\n\nOne aspect of the bass in the often spoken about groove. ", "The little things that to my knowledge just can't be notated in a chord-progress or a music sheet.", "\nMaking a song groove is for bass is mainly played in close relationship with the drumpattern(s) that are used. ", "In live situations you probably have to move both until you catch it on recordings you the one that's first has to make the choices based on instinct.", "\nLong story short what's important, imho, learn to recognize the basic patterns and feel that is often used in different kinds of music. ", "Dig into your song collection and try to identify why certain songs or parts are more appealing.", "\nAnd let it surprise you that some funky songs sometimes hold latin basslines or vice versa. ", "Reggae style with backbeat on 2 and 4 instead of 3. ", "Many things are possible, but try to recognize those major feels and what they (can) add to the beat or chord progression. ", "And what is needed to make it work.", "\n\nBig advice, follow the drummer. ", "Where does he play his main kickbeats, are they single or double? ", "For a you as a bassplayer, just try to be there when it hits the skin and often stay away from his snare beat, try to create a vacuum where it can land by dampening just before it lands. ", "It will have it's effect accentuated. ", "Drummers will like that, even the less skilled that don't have a clue what is the difference between you and that other bass-player.", "\n\nThen explore the groove by being just a fraction before on or after the kick-beat, to give it a speedy or a laid back feel depending on what the song needs in your opinion.", "\n\nYou still have to consider the chord-progression and melody. ", "Because as a bass you are the link between rhythm and melody. ", "But listen to the drummer or else he will be more or less alone. ", "Then you can experiment with basic melody-frames which can be picked up by (or used from) a lead part, voice or instrument.", "\n\nWhen these skills are getting in shape you'll have a subliminal power to 'move' a song slightly into different directions. ", "When playing live with musicians that can listen and play at the same time also they can add or alter from their little bag of tricks and then magic can happen. ", "When recording these little shifts in time and the length of the notes you play make the difference, which note is sometimes less important as long it isn't extremely 'outside'.", "\n\nI hope this doesn't scare you but makes you hungry. ", "Don't focus too much on fancy flashy notes and also master the basic timing.", "\n\nI'm a sax player...how far away from a bass player can you get? ", "More than a few of the bass players here know that I'm a nut for bass and will actively seek out tracks that have a great bass line. ", "As others have pointed out the bass is mostly responsible for the \"groove\" beyond just drumming, and it isn't necessarily about playing fast. ", "It's giving the rhythmic feel within a chordal structure so that others like me can join in and resonate with it. ", "The \"real\" bass players here can give you the lowdown on tricks and licks. ", "From my point of view it's most important that you combine two things that are seemingly incompatible. ", "1. ", "you are immaculate in your timing. ", "2. ", "Your timing doesn't sound like it's mechanical, it's got purposeful slight inflections that drive the sound, sooth it, or in some way give the rhythm \"personality\".", "\n\nMy favorite two instrument play is just bass and sax. ", "It's like an impressionist painting in which the listener only has dots or splashes of color, yet can see the whole picture and get a feeling from it. ", "Just two single note instruments describing chords, rhythm, melody, and hopefully telling a story or giving an emotion to the listener. \"", "Less\" can be \"more\". ", "That's especially true for playing music. ", "Getting the feel is most important thing. ", "Playing lots of notes, while it can be impressive, doesn't always make for good music.", "\n\nWhen I listen to professional players that I think are the best, they mostly make the music and their playing sound easy or just \"right\". ", "It's the striving amateurs that try to make music sound difficult. ", "Stretch when you practice, but play within your comfort zone when you play with others.", "\n\nLittleWing wrote:\n1.Learn the major and minor pentatonic scales for bass.", "\n2.Practice them until your fingertips bleed.", "\n3. ", "Practice them every concievable pattern and to the point you can play them while holding a converation with someone and not even think about where to put your fingers.", "\n4. ", "Practice them even more.", "\n\n99.9% of everything you will ever want to play will be the major and minor pentatonic scale.", "\n\nWhen you get bored of playing them so much , go back and find ways of unbording yourself and learning even more ways to play them.", "\nYou will eventually want to learn \"walking basslines\" but that will do no good if you dont know what to play when you are not \"walking\" so LEARN this first.", "\n\nGoogle \" minor pentatonic scale for bass\" and learn the patterns for every musical key.", "\n\nBelow is the MAJOR pentatonic for the Key of C and The Key of B. (The minor version is the same but includes some additional notes)\nNotice the patterns? ", "Notice if you change from B to the key of C what happens to your scale on the fretboard? ", "Do the notes move up or down a fret but the pattern remains the same otherwise? ", "What do you suppose happens when you want to play past the 12th fret? ", "Maybe the pattern starts over again?", "\n\nKnow this scale and how to slide it up and down the frets until you dont have to even think about it. ", "Everything will come down to the major or minor pentatonic scales.", "\n\nYour answer is ...NO. ", "You want to know the scales so well, you can hop, skip and jump around the notes in any order you find pleasing to your ear without thinking about rudimentary things like \"where should my fingers be?\" ", "You want to know them so well, you make playing them sound like YOU ARE NOT playing them.", "\n\nOkay so first thing about any song is you want to figure out what key it is in.", "\n\nThe most quick method , not having a trained ear is to find the \"Root\" note on your lower E string. ", "You can quickly go E, F, F#, G and play all the notes on just the lower E until you find the one note that fits into the song better then all the others. ", "That one note that just sounds like it matches that song is the Root note aka The Key.", "\n\nOnce you know the key ( Lets say C for example) , you can go online , print your C minor pentatonic(or major-They are same scale but minor has few additional notes)and play those notes on that chart and those notes will \"fit\" within the song. ", "You are not required to \"start\" with the root (The C).", "\n\nPracticing scales sounds boring but the trick is to learn them then make it sound like you ARE NOT playing them (Think \"Fa So La Ti Do\"...you are going to find patterns that \"fit\" using your ear, to play something that adds to that song. ", "Every song is different, every player different. ", "So its all what sounds good ..TO YOU. ", "You may find playing Fa So Fa So Fa So Do Do sounds awesome as a riff.)", "\n\nYou want to KNOW the that scale but know it so well, you can jump around the order at will without worrying \"Am I putting my fingers in the correct fret?\"or beginning worries such as that. ", "Once you know these scales , your hands will automatically play around them and you can be confident that whatever you play will somewhat \"fit\" or at least \"fit \" once you play with the song further.", "\n\nThe more you practice playing scales WITHIN a song and change them around when you find something that sounds pleasing , you will remember it , and add that to your \"knowledge base\".", "\n\nThats where experience and practice come in...certain patterns or playing on a certain part of the neck you will find things that \"work\" and add to your \"arsenal \" as a bass player. ", "After learning scales, you can watch another player and know where they're fingers are going even if playing fast because you know they can only play the notes within the scale.", "This gives you confidence that YOU can play anything they are playing if you practice or work it out.", "\n\nSo now, I am presenting the down and dirty method of learning.", "\nYou have to listen and use your ears and also get your fingers to do your command ..once the fret board stops becoming a learning mystery to you and actually becomes a playground.", "\n\nSCALES are all notes that \"fit \" within that songs \"KEY\". ", "Most any order of those notes (PATTERNS) , any way you play them, will sound good in the song, but certain patterns will sound more \"meant for the song\" to you.", "That you learn as you get experience and practice:\n\nThe scales provide a framework that is almost idiot proof to solo, add sudden fills , play basslines even though you are making the song up on the spot, or figuring it out the first time etc...etc...\n\nThe scales are your \"map\" of all the correct notes for that song. ", "The sequence you play them in is up to your creativity and imagination. ", "There is no \"right or wrong\". ", "its all YOU.", "\n\nSo your command of the major and minor pentatonic will give you:\na. Confidence anything you play sounds correct within a song.", "\nb. A framework to assemble particular notes to create a \"riff\" or a \"bassline\".", "\nc.You can improvise on the spot and sound good playing with a guitarist or saxist or keyboardist because they are playing that same scale and practice and experience will instinctively tell you where the song is heading or what they probably will do next in the song even if its the first time playing it because you know from your experience and ear..WHAT FITS.", "\n\nSo no, while C may be the root , your job is not to play the scale sterile and robotically.", "\n\nYour job is to know those notes so well, you can hop, skip and jump around them in a pleasing manner for whomever is listening to you.", "\nEdited by LittleWing on January 04 2019 06:56\n\nWe now want to work with ONLY FOUR notes. ", "G, A C, and D which are in the A scale.", "\n\nOn your lower E string find The G on your 3rd fret and the A on your lower E 5th fret.", "\n\nG and A on the lower E string-A million rock songs were built using those two notes.", "\n\nNow find C and D on your lower A string. ", "This will be on the 3rd fret and the fifth fret of the A string.", "\n\nSo we have G and A and also C and D on the string above it.", "\n\n4 notes that are in the A Pentatonic scale.", "\n\nThose four notes are 90% of Rock Music right there! ", "Its insane how many songs are just those four notes!", "\n\nNow...Find a drum track with just drums. ", "You can search Wikiloops for drum only tracks in \"Rock\".", "\n\nOnce you find one, any speed and every drummer will be different...make a song using only those four notes.", "\n\nUse G and A for your Verse.", "\n\nUse C and D for the chorus of the song.", "\n\nMake a simple song playing with the drums. ", "Its all your creativity HOW you play those four notes. ", "Play them any way you feel pleases you.", "\n\nTry to blend in with the drummer because as a bassist, the drummer is really the only guy in the band you really need to concern yourself with as you and he are the foundation of the songs rhythm.", "\n\nCreate a \"groove \" that sounds good. ", "It doesnt matter the style of music you play those notes in (You can try to sound \"Reggaey, or \"Metalish\"...etc..) Change them any way that you think your song sounds good. ", "In any band or musical style the drummer and bassist are the all important foundation. ", "It shouldnt matter if the guitarist is playing like Eddie Van Halen or BB King. ", "You should find the drummers \"pocket\" where you and he mesh perfectly like a well oiled machine. ", "The vocalist and guitarist and all other band members become secondary in your role as bassist. ", "You and the drummer \"set the groove\" of the song or in metal music...the \"thump\".", "\n\nIf you feel it isnt happening with that drummer , find another one and try with that drummer. ", "Maybe one drummer you feel you \"CONNECT\" with . ", "That happens all the time in bands. ", "Certain players you will be attracted to others not so much.", "Playing music is an extremely personal , cerebral thing . ", "Its normal to prefer a certain players style over another ones.", "It doesnt mean any one is \"bad\", it just means you work better with one person rather then another.", "\n\nOnce you make a song out of those four notes. ", "Replay that song and figure out from the scale what notes AROUND the notes you played , you can use as \"fills\".(Fills are little patterns of the scale used to make what your playing blend the song better. ", "Kind of blend in sections better. ", "They are usually short and \"spice\" up your playing . ", "-Maybe like three notes that you throw in after you are done with the A and are now going to the C and D part.", "\n\nThose four notes have created thousands of number #1 songs. ", "Use creativity and imaginatrion and try to find a \"pleasing groove \" while playing those four notes with a drummer. ", "You can play with several drummers and get several completely different sounding songs but yet...its still just those four notes.", "\n\nLearn to change the pattern around with each drummer and then slowly when you are comfortable , add in notes that surround those four. ", "Look for notes close by , in the A scale , that when played at a certain time , maybe add to the song and make it even more pleasing to you.", "\n\nIt should be FUN , not tedious and boring.", "\n\nScales are the roadmap to playing any style of music. ", "The Pentatonics are the most commen scale you hear on the radio. ", "The key is to know them so well , your fingers automatically know where to go once you know the songs key and you know the corresoponding Key scale . ", "You can be confident knowing the key and the keys scale , most anything you play will \"sound correct\" in the context of the song. ", "You can also figure out songs knowing the scale because you will know roughly whereabout what the other person is playing.", "Its your key to the fun and enjoyment of making music you are proud of .", "\n\nI am not discouraging further study of music theory howver I just gave you the laymans guide to learning bass. ", "You can read and study and nothing wrong with that but bass is an \"ear\" extensive instrument. ", "You have to learn to get loose and funky and a book cannot teach that.", "Nor can you read about \"bonding with a drummer to create a groove or lay down the \"thump\" in a metal song\". ", "You just have to do it.", "\n\nPlay , Play and play some more.", "\n\nI learned guitar playing to my brothers Led Zeppelin IV album when I was 12 . ", "Picked out the notes. ", "Even the solos and can still play that album note for note all the way through start to finish. ", "If i was confused or had trouble , I would go to the music store, find the sheet music and roughly get an idea of what chords were being played at the part and then figure it out from there.", "\n\nSo have fun with it and always look for FUN ways to learn. ", "Music is about freedom and pleasure. ", "Make what you play, even if only one note...FUN to listen to.", "\nEdited by LittleWing on January 04 2019 08:03\n\nPlease note: As you are visiting wikiloops, any personal data that is being processed is treated in compliance to the European General Data Protection Regulation. ", "You may review our data privacy policy to learn how and why we are using Cookies and other techniques as we are providing our service to you." ]

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[ "It has now been a little over one week since AT&T announced that it would officially unlock customer’s iPhones if they met certain requirements. ", "The resulting rush overloaded support representatives, with sources inside AT&T telling ExtremeTech that the queue exceeded 10,000 at its highest points last week. ", "Those early adopters as a result waited nearly a week in some cases for the unlock to be authorized.", "\n\nWhy did the queue grow so big, so fast? ", "The unlocking procedure, and AT&T’s rules on eligibility we’re told. ", "While unlocking most phones can be done without the interference of the manufacturer, Apple does it differently. ", "Access to the tool is limited to technical support and members of AT&T’s “unlock” team, so talking to a regular old customer support rep is not going to do you any good.", "\n\nAfter verifying you meet the requirements, the technical support representative then enters your IMEI (the phone’s identification number) into the tool provided by Apple, which in turn activates the unlock and sends the confirmation email to the user. ", "If you contact customer support, those representatives can only open a case ticket, which depending on workload could take days to resolve, our source says.", "\n\nSo what’s the quickest route to unlocked bliss? ", "Make sure all your ducks are lined up before attempting to unlock your iPhone. ", "The result is a much less painful process. ", "Based on my own experience and what we’re hearing, here’s how to legally unlock your iPhone in short order:\n\n1. ", "Verify you’re eligible. ", "Check your account to ensure it is paid up-to-date. ", "Make sure the iPhone you are attempting to unlock is not attached to an account that is under contract. ", "That basically means an old iPhone that’s under a plan which is still under contract is likely not eligible. ", "The easiest phones to unlock will be those that are not associated with any account and over two years old, it seems. ", "If you’re ineligible, be prepared to pay the early termination fee to unlock.", "\n\n2. ", "Make a note of your IMEI. ", "The technical support representative will need this number, so it’s a good idea to jot it down now. ", "The IMEI can be found by tapping Settings, then General, then About, then scrolling to the bottom. ", "The IMEI is a 15-digit number. ", "Write it down and place it to the side.", "\n\n3. ", "Backup your device now. ", "If you haven’t synced in awhile, now’s the time. ", "The unlock process requires a wipe of the device. ", "Connect the iPhone to iTunes and allow it to back up. ", "If you use iCloud, many of your settings and basic information is likely already backed up to the cloud, but better to be safe than sorry.", "\n\n4. ", "Call AT&T directly. ", "Call into AT&T’s customer support. ", "Don’t use the company’s online support system, or in-store representatives. ", "Follow the prompts and press “2” for Technical Support when the options for the main menu is listed. ", "Select option “0” to speak with a representative. ", "Make clear that you’re attempting to unlock your eligible iPhone. ", "If you’re not, you will need to tell them you agree to pay for the early termination fee for the right to unlock the device.", "\n\nAt this point, the process is in AT&T’s hands. ", "They should process your unlock immediately since you are talking to a representative with direct access to the tool. ", "Wait for the email to confirm the unlock has been processed.", "\n\n5. ", "Reconnect your iPhone to iTunes. ", "After receiving the email, re-pair your device with iTunes. ", "Under the “Summary” tab and “Version” section, click on Restore. ", "Allow the device to restore as normal. ", "When the restore completes, iTunes will display the message “Congratulations, your iPhone has been unlocked.” ", "If you wish to restore your data, click “Continue,” otherwise it is safe to disconnect.", "\n\nPlease note that if you are taking the iPhone to a different carrier, some settings will need to be changed in order for features like web surfing and picture messaging to work. ", "Although it varies from carrier to carrier, many are happy to provide you with the necessary settings to ensure proper operation. ", "For example, T-Mobile has easy-to-follow directions to set up an iPhone.", "\n\nYour performance may vary, and on some carriers, it still may be necessary to jailbreak in order for all features to work. ", "For example, iPhone users on T-Mobile experience MMS receipt issues — it appears an fix only available for jailbroken phones will fix that issue according to what we’re seeing.", "\n\nEither way, good luck and happy unlocking!" ]

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[ "World’s Worst Guitar Interface: Your Cell Phone\n\nSolving a problem none of us knew existed, Motorola has patented a method for entering notes into a cellphone via an “intuitive” method that emulates frets. ", "Pay close attention, and see if you can make sense of this:\n\n. . . ", "an input specifying a root note (FIG. ", "2) indicating a position on a neck of a stringed instrument and associating at least one column of input keys such as numeric keys of the mobile communication device with a string of the stringed instrument. ", "Numeric keys next to one another and within a same column can specify notes which vary by approximately a half-step. ", "The method also can include detecting at least one activation of the numeric keys specifying at least one additional note to be played substantially concurrently or in a defined sequence with the root note, thereby specifying a musical chord.", "\n\nAnyone feel like they’re in theory class — on another planet? ", "A jog wheel / joystick is navigating the circle of fifths, so you actually can fit a range of chords on the 9(!) ", "keys of a cell phone. ", "Not answered in the patent: would anyone go to this much trouble to create ringtones? ", "Desktop app, anyone? (", "Or there’s always that weird ringtone keyboard from CME.)", "\n\nVia Textually, and thanks to John at Gizmodo. (", "Yeah, I’m late, but I’ve been deep in Jitter and had to be in the right frame of mind to read this insanity.) ", "Priceless comment by SuppleMonkey: “Really? ", "I’d just rather have a cell phone that made calls as reliably as my land line.”" ]

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[ "1. ", "Field of the Invention\nThis invention pertains generally to the field of mechanical locking devices of the type having a rod normally locked against axial movement through a lock housing by a clutch spring of reduced diameter, where the rod is released by partially unwinding the spring.", "\n2. ", "State of the Prior Art\nThe device of this invention pertains to a class of mechanical locks which generally have a rod axially movable through a lock housing, one or more coil springs tightly wound about the rod and axially fixed to the housing so as to normally grip the rod against movement through the housing. ", "A release is provided for partially unwinding the coil spring or springs such that the internal diameter of the spring is increased and the rod is released for axial movement relative to the lock housing. ", "Linear locks of this type have been in widespread use, particularly in recliner seats used in automobiles and other vehicles. ", "In such installations, the housing of the mechanical lock is attached to one of the reclinable backrest or the stationary seat, while the end of the rod is connected to the other of those two seat components. ", "In its normally locked condition the device fixes the position of the backrest. ", "If the occupant desires to reposition the backrest, the lock is manually released, which frees the rod and allows movement of the backrest. ", "The mechanical lock typically has a heavier exterior coil spring which returns the rod to an extended condition when the lock is released. ", "For example, the spring may serve to bring the seat backrest to a fully upright condition. ", "One relatively early example of such a lock is disclosed in U.S. Pat. ", "No. ", "3,874,480 issued to Porter et al. ", "and owned by the Assignee of this patent application.", "\nIn applications where bi-directional loading of the rod is anticipated, two springs may be provided, one on each side of a common release lever and axially contained between two end bushings, each bushing engaging an end tang of a corresponding spring to fix the tang and the outer end coils of the spring against rotation about the rod. ", "The inner end coils of the springs are connected to a release lever, actuatable for simultaneously unwinding both springs to free the rod for axial movement through the housing.", "\nThe bushings serve three distinct functions. ", "An axial bore in each bushing defines a radial bearing surface which supports the rod for sliding movement through the lock housing. ", "A radial slot in the bushing receives an end tang of the spring, to circumferentially fix the outer end of the spring and prevent this end of the spring from turning about the rod. ", "Finally, an axial bearing surface on the bushing is circumferentially spaced by 90 degrees from the spring tang. ", "When the spring is pulled with the rod against the axial bearing surface by a load acting on the rod relative to the lock housing, the end coils of the spring are canted relative to the rod axis. ", "This canting deforms the coils from a normal circular shape to an ellipsoid shape, and substantially increases the frictional engagement between the spring coils and the rod. ", "The clutch spring better resists the load and makes for a more positive lock of the rod relative to the housing so long as the loading condition persists.", "\nPrior art locks also feature a tubular sleeve which closely envelops the spring or springs, to prevent the coils from unwinding preferentially at the release lever while the coils at the opposite end remain in a rod gripping condition. ", "The sleeve prevents this result by distributing the unwinding action more evenly along the length of the spring so that all coils release the rod at substantially the same time, for positive, quick release action of the lock.", "\nEarly locks of this type were housed in a cylindrical tube open at one or both ends. ", "The clutch spring was mounted on the rod, and other components such as end bushings, actuator levers, etc. ", "all were assembled onto the rod and then inserted into the housing. ", "The housing wall was then swaged or welded to hold the internal components in axially fixed position within the housing. ", "The relative positions of the lock elements in the housing is rather critical and a high degree of precision must be maintained in assembling the lock. ", "A tube type housing makes this objective difficult to achieve with consistency.", "\nMore recently, the tube style housing has evolved into a two-piece clam shell housing, described in European patent application number 85201888.6 filed Nov. 18, 1985, Publication number 0 182 440 83. ", "An envelope or housing is formed by two half-shells. ", "The rod is first fitted with the two coil springs, a release lever including a containment sleeve about the springs, and a pair of end bushings which engage the ends of the coil spring. ", "The half-shells are mated to each other with the rod assembly in-between, and welded to the bushings to form an enclosure about the rod. ", "The axial spacing between the bushings is fixed by this welding, with springs axially contained between the bushings. ", "The rod slides through the bushings and the housing when the spring is unwound to permit such movement.", "\nThe need to weld bushings to a lock housing has been a source of difficulty in prior art locks. ", "In practice, it is very difficult to produce locks with welded bushings which are perfectly aligned with the rod axis, and such misalignment introduces a degree of frictional drag into the lock mechanism. ", "In addition, the bushings add significantly to the cost of the lock, and may have to be differentially hardened to provide hard bearing surfaces as well as untreated portions which can be welded.", "\nU.S. Pat. ", "No. ", "5,157,826, commonly owned with this application, describes a method for making a linear mechanical lock in which the number of component parts is reduced by fabricating the lock housing from a single sheet of metal and embossing various elements, which previously constituted separate parts, into the single sheet. ", "In particular, the interior dimension of the housing is such as to closely encompass the clutch springs to promote even unwinding of the spring along its length upon actuation of the lock release without a separate containment sleeve. ", "While this prior invention represents a substantial contribution to the state of art, further improvements have been made which facilitate fabrication and assembly of the linear lock while at the same time improving the precision of the lock assembly for smoother, easier and faster lock operation." ]

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[ "Gardzin\n\nGardzin () is a village in the administrative district of Gmina Resko, within Łobez County, West Pomeranian Voivodeship, in north-western Poland. ", "It lies approximately east of Resko, north-west of Łobez, and north-east of the regional capital Szczecin.", "\n\nBefore 1945 the area was part of Germany. ", "For the history of the region, see History of Pomerania.", "\n\nReferences\n\nGardzin" ]

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[ "Q:\n\nCalling var array=[] within each function\n\nI'm working on a project where I have different sets of div like heading, text, image etc..\nUpon clicking I want to append input boxes for that relevant numbers of divs.", "\nYou can see working fiddle here : http://jsfiddle.net/UN62E/\nThis script does a job for me but I need improvement with this script.", "\nThis is how part of my script look like :\nvar eltofind = \"heading\";\n\nif($(this).find(\".\" ", "+ eltofind).length !", "= 0){\n\n var eltoget = $(this).find(\".\" ", "+ eltofind);\n\n $(eltoget).each( function(index) {\n var item = $('input.' ", "+ eltofind + ':first').clone();\n var count = (index +1);\n var getting = eltofind + \"-\" + count;\n item.addClass(getting);\n item.appendTo('#input');\n });\n}\n\nCurrently I'm repeating whole script for individual sets of div. ", "Is there a way to call all sets of divs within array? ", "for example : \nvar eltofind = [\"heading\", \"text\", \"image\"] \n\n& call them within each function ? ", "\nMy jQuery skills aren't that good & Any help would be appreciated. ", "\n\nA:\n\nYou can make multiple selectors in jQuery\n$(\".heading, .text, .image\").foo();\n\nA:\n\nCreate a loop that loops through each value of eltofind and performs the appropriate actions.", "\nvar eltofind = [\"heading\", \"text\", \"image\"];\n\nfor(var i=0; i < eltofind.length; i++){\n var thisElement = eltofind[i];\n\n if($(this).find(\".\" ", "+ thisElement).length !", "= 0){\n\n var eltoget = $(this).find(\".\" ", "+ thisElement);\n\n $(eltoget).each( function(index) {\n var item = $('input.' ", "+ thisElement + ':first').clone();\n var count = (index +1);\n var getting = thisElement + \"-\" + count;\n item.addClass(getting);\n item.appendTo('#input');\n });\n }\n}\n\n" ]

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[ "Skibby Chronicle\n\nThe Skibby Chronicle (Danish: Skibbykrøniken) is a Danish chronicle written in Latin and dating from the 1530s. ", "The original manuscript was found during 1650, walled in behind the altar of Skibby Church (Skibby Kirke). ", "It was printed in Latin 1773 and translated into Danish 1890-1891.", "\n\nHistory\nIt was found in Skibby Church (Skibby Kirke) in North Zealand, Denmark. ", "It is anonymous but according to many historians, the author was the outstanding humanist Poul Helgesen (Latin: Paulus Helie). ", "Formally the work covers the period 1047-1534, but the main part covers events during the reigns of King Christian II and King Frederick I.\n\nThe work is a sometimes very personal description of Danish history during the last decades of Roman Catholicism, marked by the author’s sympathy for and (mainly) antipathy against the political actors. ", "Especially his portrait of Christian II is a very subjective one, affected by his negative attitude to the king’s anti-aristocratic policy and his use of violence. ", "Also Frederick I, regarded by Helgesen as a traitor to the Roman Catholic cause, is harshly treated. ", "The description ends abruptly during the Count’s War (1534–36), perhaps because of Helgesen’s death ca. ", "1534.", "\n\nFormally the chronicle is built up very much like the annals, which means that great and small events are often mentioned together – deaths among the local clergy alternating with battles and wars – but it often contains valuable material. ", "For instance, the nobility’s letter of complaint over Christian II is repeated.", "\n\nIn general the chronicle reflects the author’s bitterness, sorrow and frustration because of the course of events. ", "His hot temper often breaks through, invectives and personal injuries reveal a man who was deeply engaged in the struggle. ", "His hatred toward the Protestant agitators is just as outspoken as is his contempt and indignation at the last Roman Catholic bishops and their behaviour. ", "In spite of this subjectivity, the chronicle makes an interesting picture of pre-Reformation Denmark viewed through the eyes of a disillusioned Reform Roman Catholic.", "\n\nReferences\n\nCategory:1530s books\nCategory:Danish chronicles\nCategory:16th-century Latin books\nCategory:16th-century history books\nCategory:Works published anonymously" ]

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[ "[Diagnostic possibilities of CT-guided lung biopsy].", "\nThe authors analyse the results of computer-aided tomographic biopsies in 81 patients with various pulmonary diseases (63 with tumors, 53 of these with malignant ones, and 18 with nontumors diseases). ", "Positive results were obtained in 86.4% of cases. ", "Biopsies proved to be informative in 44 out of 48 patients with lung cancer, in 8 out of 10 ones with benign tumors, and in 10 out of 12 ones with nonspecific inflammations. ", "The results were not informative in 13.6% of patients. ", "In 4 cases the failure was caused by the absence of cellular material in the puncture biopsy specimen, in 5 it was due to the presence of only pulmonary cells. ", "In two more cases the diagnosis of lung cancer made by computer-aided biopsy was erroneous because of the presence of inflammation elements and amorphous mass in the examined. ", "Complications occurred in 22 (27.2%) patients, pneumothorax in 16 (19.8%) and local pulmonary hemorrhages in 6 (7.4%) of these. ", "Hence, computer-aided biopsy of the lung is an informative diagnostic method, permitting a correct diagnosis in the majority of cases." ]

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[ "Charts Spelling 'Big Trouble' for SilverContributed Opinion\n\nSource: Clive Maund for The Gold Report (4/11/17)\n\nSilver's latest charts show that it is set up for a potentially severe decline, says technical analyst Clive Maund.", "\n\nSilver's latest charts show that it is set up for a potentially severe decline, a situation that is aggravated by its latest COTs and Hedgers charts showing record extreme readings, which mean BIG TROUBLE for silver. ", "Now, you might think, like so many traders did on Friday morning, that with Cruise Missiles flying around the Mideast, the outlook for the Precious Metals couldn't be better, but the charts are saying that this is an opportunity—on the short side—dressed up in a crisis that will soon ease.", "\n\nAction in silver on Friday was very bearish as we can see on its 6-month chart below—it tried to break higher in the morning but the breakout attempt failed and it dropped back, zig-zagging around and leaving behind a high volume \"Spinning Top\" candlestick on its chart, so that it looks like it is about to break down from a Double Top with its highs of late February.", "\n\nThe 1-year chart shows silver perched on the edge of a cliff, at the top of a big expanding downtrend channel with no relief in sight until it reaches the support level shown, and COTs and Hedgers charts show that it could drop much further—to the lower boundary of this expanding channel.", "\n\nThe risk of silver tipping into a potentially severe decline from here is amplified by its latest COT chart readings, which show that Commercial short and Large Spec long positions have risen to at least one-year extremes. ", "This is viewed as meaning BIG TROUBLE for silver.", "\n\nThe gravity of the situation facing silver is made even more clear by the latest Hedgers' chart, which shows that Hedgers' positions are at all-time bearish extremes. ", "This chart makes it extremely unlikely that silver will or can advance from here—more likely is a severe decline back towards the lower boundary of the expanding channel shown on silver's 1-year chart above. ", "Needless to say, the grim outlook for silver set out here also has bearish implications for gold, where the COT and Hedgers' charts are nowhere near as decisive.", "\n\nChart courtesy of sentimentrader.com\n\nClive Maund has been president of www.clivemaund.com, a successful resource sector website, since its inception in 2003. ", "He has 30 years' experience in technical analysis and has worked for banks, commodity brokers and stockbrokers in the City of London. ", "He holds a Diploma in Technical Analysis from the UK Society of Technical Analysts.", "\n\nWant to read more Gold Report articles like this? ", "Sign up for our free e-newsletter, and you'll learn when new articles have been published. ", "To see recent articles with industry analysts and commentators, visit our Streetwise Interviews page.", "\n\nDisclosure:\n1) Statements and opinions expressed are the opinions of Clive Maund and not of Streetwise Reports or its officers. ", "Clive Maund is wholly responsible for the validity of the statements. ", "Streetwise Reports was not involved in the content preparation. ", "Clive Maund was not paid by Streetwise Reports LLC for this article. ", "Streetwise Reports was not paid by the author to publish or syndicate this article.", "\n2) This article does not constitute investment advice. ", "Each reader is encouraged to consult with his or her individual financial professional and any action a reader takes as a result of information presented here is his or her own responsibility. ", "By opening this page, each reader accepts and agrees to Streetwise Reports' terms of use and full legal disclaimer. ", "This article is not a solicitation for investment. ", "Streetwise Reports does not render general or specific investment advice and the information on Streetwise Reports should not be considered a recommendation to buy or sell any security. ", "Streetwise Reports does not endorse or recommend the business, products, services or securities of any company mentioned on Streetwise Reports." ]

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[ "Fishtail Coca Cola Barstool\n\nSeat Height: *\n\nDescription\n\nFishtail Coca Cola Barstool With Foot Rest\n\nOur Coca Cola Fishtail Barstool with Foot Rest features the Authentic Coca-Cola Brand, Designed for Heavy Duty Commercial Usage, 24” or 30” Tall Options, Chrome Grooved Seat, Black Arciform Seat Icon, AND Proudly Made in USA! ", "Our barstools are rated for up to 400 lbs! ", "Commercial Quality – and built to last! ", "Nothing says it like Coca Cola! ", "Known for so many years for their authentic and dynamic advertising of their fabulous product! ", "Lifetime Structural Frame Warranty and rated for up to 400 lbs!" ]

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[ "We missed this, but lots of folks are talking about it. ", "A week ago, two days after the Brussels Jewish museum killings on May 24, Jeffrey Goldberg wrote with singularly bad judgment on twitter:\n\nAt what point do the Jews of America and the Jews of Israel tell the Jews of Europe that it might be time to get out? — ", "Jeffrey Goldberg (@JeffreyGoldberg) May 26, 2014\n\nThis was days before anyone had any firm idea of who had committed the horrific murders, five days before the news that a French man who had become radicalized by serving in the Syrian rebellion was arrested.", "\n\nThe tweet is a reminder of Goldberg’s visceral understanding that Jews are unsafe in the west. “", "The fear of anti-Semitism is the forge on which” he built his identity as a young Jew, he wrote in his memoir, Prisoners. “", "I believed a red river of anti-Semitism ran under the surface of America.” ", "Jews led “the dog’s life of the Diaspora. ", "We were a whipped and boneless people.” ", "The cure then was that Goldberg moved to Israel.", "\n\nMax Blumenthal has responded to Goldberg:\n\nAnti-Semites and Zionists like @jeffreygoldberg have something in common: They want Jews to leave Europe. ", "https://t.co/nqtcTc3D6M — Max Blumenthal (@MaxBlumenthal) June 2, 2014\n\nThe American Jewish Committee’s David Harris in Haaretz surely agrees in part with Blumenthal. ", "He chides Goldberg:\n\nSuch reactions are not helpful. ", "They take complex issues and reduce them to the level of simplistic slogans. ", "Should we be outraged by violent attacks on Jews? ", "Absolutely. ", "Should we be concerned about the electoral success of extremist parties peddling anti-Semitism, xenophobia, and racism? ", "Certainly.", "\n\nThe pugnacious Goldberg seems proud of his tweet.", "\n\nMore on Brussels, from the Telegraph report on the arrest of a French man who had reportedly served with jihadists in Syria for the murders:\n\nOur message “to these jihadists is that we will fight them, we will fight them and we will fight them”, [French President Francois Hollande] said.", "\n\nFrance announced new policies in April to stop its citizens joining the Syrian civil war, aiming to prevent young French Muslims becoming radicalised and posing a threat to their home country.", "\n\nThis is a growing worry in a country that is home to Europe’s largest Muslim and Jewish communities.", "\n\nNearly 800 French nationals have travelled to Syria to fight alongside jihadists in the war-torn Arab state.", "\n\nWhen Goldberg urges Jews to leave for Israel or the U.S., it raises the question, How safe are Jews in Israel? ", "Everyone is worried about violence there for good reason; the Israelis are holding millions of people in occupation. ", "And, the inevitable question: what is the contribution of Israel’s actions to fostering anti-Semitism?" ]

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[ "News, views and top stories in your inbox. ", "Don't miss our must-read newsletter Sign up Thank you for subscribing We have more newsletters Show me See our privacy notice Invalid Email\n\nCamellia Cheshire was plunged into the depths of despair twice after her brother was “falsely accused of rape”.", "\n\nShe says that first her beloved Jay, 17, committed suicide after having “the life sucked out of him” by the allegation which was withdrawn two weeks later.", "\n\nThen, a year later, their mother Karin took her own life the same way – leaving desperate Camellia to organise another funeral.", "\n\nToday she tells how she wept as she picked out a garland of Karin’s favourite purple carnations to sit on top of the wicker coffin.", "\n\n(Image: Sunday Mirror)\n\nJay’s ashes had been placed inside – so, Camellia says, “he and mum could be together”.", "\n\nCourageous Camellia is now 22 and talks for the first time about an ordeal that tore her family apart.", "\n\nAnd in a heartbreaking interview, she says the trauma drove her to the brink of suicide too.", "\n\nShe confesses the only thing that stopped her was knowing that a third death would destroy her devastated gran Ann, 79.", "\n\nTearful Camellia says: “When I saw my mum’s body I sank to the floor, screaming and crying, asking why this had happened to me. ", "It just seemed so unfair. ", "At nights I’d lie in bed and cry because I felt so alone.", "\n\n“I’d already struggled with thoughts of suicide myself after Jay died and when mum went those feelings surfaced again.", "\n\n“I thought about it many times but I couldn’t do that to my nan. ", "It would have broken her.", "\n\n“I decided I had to be strong and live for the family I have left.”", "\n\nCamellia claims the girl who accused Jay met with him before his death and tearfully admitted someone had put pressure on her to make the false sex abuse claim.", "\n\nEvery day, Camellia contemplates contacting the girl in her desperate bid for answers, but hasn’t yet because she fears the effect it would have on her own mental health.", "\n\nCamellia goes on: “It’s so hard to accept that if it hadn’t been for the rape investigation Mum and Jay would still be here. ", "I’ve lost my whole world.", "\n\n“The girl met with Jay before he died and said someone had forced her to say such horrible things about him, but the life had already been sucked out of him.”", "\n\nThe family’s ordeal began in summer 2015 when the girl went to police.", "\n\nJay, who suffered depression as a child, attended a voluntary interview with Camellia by his side. ", "He was never charged and the allegation was withdrawn after two weeks – though Jay did not find that out until much later.", "\n\nCamellia recalls the ordeal of watching Jay “sitting in a police station being questioned like he was a serial sex offender”. ", "She says: “I broke down seeing him break down. ", "I was so protective of him and he was so sensitive.", "\n\n“After that night, he was never the same person. ", "I’d hear him crying himself to sleep every night – big, bellowing sobs. ", "It broke my heart.", "\n\n“It was only when my mum contacted the police that we were told the allegations had been withdrawn.", "\n\n“Jay eventually got a letter but seeing the word ‘rape’ next to his name plunged him even further into turmoil.”", "\n\nSix weeks later, barmaid Camellia was rushing out to work in Southampton and didn’t say goodbye properly to Jay. ", "She bitterly regrets not answering phone calls he made to her during her shift. ", "She explains: “Our last conversation was really horrible. ", "I was stressing because I was late and he wanted to show me a silly video about kittens.", "\n\n“I didn’t say goodbye or give him a hug because I had to leave for work. ", "Then he called three times but I couldn’t answer because I was working. ", "Now I realise he was probably going to say goodbye, or tell me he loved me.", "\n\n“Next morning, there was a knock at the door and I heard my mum scream. ", "She came into my room, tears streaming, and said Jay had hanged himself.”", "\n\nA passerby found him in a local park and paramedics had restarted his heart.", "\n\nBut he had permanent brain damage and two days later Karin made the heartbreaking decision to switch off his life support.", "\n\nCamellia adds: “The night before he died, I spent four hours lying next to him while Mum slept. ", "It was horrible to think we hadn’t had a proper goodbye.", "\n\n“The family all gathered at his bedside. ", "I held his left hand and Mum his right. ", "He squeezed my hand really tightly just before the end. ", "Doctors might say it was a spasm but I like to think it was his way of saying goodbye. ", "Then I put my ear to his chest as his heart slowly stopped beating and the colour drained from his face.”", "\n\nThe ordeal plunged Karin, who had bipolar disorder, into turmoil and she had a nervous breakdown five days later.", "\n\nShe spent six months in ­psychiatric units while Camellia was left to cope with her grief alone – and live on her own for the first time.", "\n\nShe says: “It was like I’d already lost Mum as well as Jay. ", "We’d been so close. ", "She was so kind. ", "She was my best friend but she started to say really hurtful things. ", "The worst moment was when she told me she wished it had been me instead of Jay. ", "I knew it was the illness speaking but it still killed me.” ", "Karin, who was separated from her children’s father, was released from hospital in early 2016 but was never her old self again.", "\n\nThe family fear mental health workers did not correctly identify the risk that she posed to herself.", "\n\nCamellia begged several times for her mum to be sectioned, but to no avail. ", "The stress was so great that Camellia moved out, temporarily.", "\n\nKarin fell into debt and looked for a new home to share with Camellia. ", "But she could not beat her demons.", "\n\n(Image: Sunday Mirror)\n\nCamellia recalls sadly: “The day before she died she told me I needed to clear out my room but I didn’t understand why she was in a rush. ", "Now I realise it was because she planned to kill herself.", "\n\n“She was stressing me out and I started to cry when she asked what I’d do if she died in her sleep or had a heart attack.", "\n\n“When I left, she was on the sofa crying. ", "She gave me a hug but it wasn’t like we normally hugged and she shut the door on me more quickly than she’d ever done before.”", "\n\nNext day, police broke the harrowing news that Karin was dead. ", "Camellia said: “I screamed so loudly. ", "I demanded to see my mum. ", "I lay by her body screaming and crying.”", "\n\nCamellia is now sharing her story in the hope other suicidal people will seek help.", "\n\nShe says: “I never want anyone else to feel this pain. ", "I hope one day I have the strength to seek the answers I need, but I’m not sure if I could handle the truth at the moment.", "\n\n“Whatever Jay’s accuser says will not bring either of them back.”" ]

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[ "Introduction {#sec1_1}\n============\n\nGitelman syndrome (GS) is an autosomal recessive disorder caused by pathogenic mutations of the Solute Carrier Family 12 Member 3 (*SLC12A3*) gene \\[[@B1], [@B2]\\], with a prevalence of 1--10 per 40,000 \\[[@B1]\\]; its symptoms are metabolic alkalosis, hypokalemia, hypomagnesemia, and elevated plasma renin and aldosterone. *", "SLC12A3* encodes the thiazide-sensitive sodium-chloride cotransporter expressed in the renal distal convoluted tubules \\[[@B3]\\] and works to transport electrolytes to control their concentration. ", "It is sometimes difficult to differentiate GS from other salt-losing nephropathies by using only clinical and laboratory data; therefore, genetic testing of *SLC12A3* is recommended for individuals with clinically suspected GS \\[[@B1]\\]. ", "Recently, the increasing availability of next-generation sequencing (NGS) for genetic testing allows us to find many variants in genes of interest, and the classification of variants may change with accumulation of population-based genetic data and functional studies: some variants that were previously classified as pathogenic were reclassified as benign \\[[@B4]\\], whilst others of previously unknown significance were confirmed as pathogenic. ", "Here, we present a mutation analysis of *SLC12A3* in a three-generation Japanese family including a child with GS.", "\n\nCase Report {#sec1_2}\n===========\n\nThe family tree of the GS patient is shown in Figure [1a](#F1){ref-type=\"fig\"}. ", "The proband was a 16-year-old Japanese girl with muscle weakness and continuous hypokalemia and alkalosis. ", "This condition had first been noticed when she was 10 years old. ", "Biochemical analysis revealed hypokalemia (2.8 mmol/L); elevated plasma renin activity (40 ng/mL/h at bed rest; normal range, 0.5--2.0) and aldosterone (76.5 ng/mL in the early morning at rest; normal range, 3.6--24.0); and decreased urinary excretion of calcium (0.009 g/day; normal range, 0.1--0.3). ", "The blood pressure was not elevated (93/48 mm Hg). ", "Renal ultrasound revealed normal kidneys, and the blood urea nitrogen (BUN) and creatinine values were within normal range (11.9 and 0.56 mg/dL, respectively). ", "On the basis of the clinical symptoms and laboratory results, GS was suspected. ", "To determine the causative mutations, NGS screening was carried out by using SPEEDI-KID \\[[@B5]\\] on the patient and her family members -- her asymptomatic mother (aged 41 years) and asymptomatic maternal grandmother (aged 72 years) -- and subsequently validated by Sanger sequencing using the primer pairs 5′-GCTTCACCATCAGCACACTG-3′ and 5′-GAGGAAGGAGTGCAGGTCAG-3′ for rs371443644 (NM_000339.3:c.179C\\>T, NP_000330.3:p.", "Thr60Met), 5′-GCAGCTCTGGCCTAGAAAGA-3′ and 5′-GCACCTGGCTTCTTGTAGATG-3′ for rs79351185 (NM_000339.3:c.1706C\\>T, NP_000330.3:p.", "Ala569Val) and rs139329616 (NM_000339.3:c.1732G\\>A, NP_000330.3:p.", "Val578Met), and 5′-CTCACCCTCCTCATTCCCTA-3′ and 5′-GACAATCTCAGTGCCCACCT-3′ for rs185927948 (NM_000339.3:c.2573T\\>A, NP_000330.3:p.", "Leu858His). ", "In haplotype analysis for rs79351185 (p.Ala569Val) and rs139329616 (p.Val578Met), TA cloning of the PCR product was performed with the grandmother\\'s DNA using the primers 5′-GCAGCTCTGGCCTAGAAAGA-3′ and 5′-GCACCTGGCTTCTTGTAGATG-3′. The PCR product was cloned into T-vector pMD20 using a Mighty TA-Cloning Kit (TaKaRa Bio Inc., Shiga, Japan) according to the manufacturer\\'s instructions. ", "Colonies were subjected to PCR amplification, and direct sequencing using the PCR product was performed. ", "This study was approved by the institutional review boards of the University of Tsukuba (H30--57) and Tokyo Medical and Dental University (G2000-80), and written informed consent for publication was obtained from all the participants.", "\n\nFour single-nucleotide variants in *SLC12A3* that have been previously reported in GS patients were detected: rs371443644, rs79351185, rs139329616, and rs185927948 (Fig. [", "1b](#F1){ref-type=\"fig\"}). ", "TA cloning of the PCR products revealed that the Val allele of p.Ala569Val and the Met allele of p.Val578Met were located on different chromosomes; thus, the patient\\'s maternal grandmother was compound heterozygous for the two variants p.Ala569Val and p.Val578Met (Fig. [", "2](#F2){ref-type=\"fig\"}). ", "Her asymptomatic mother carried the Met allele of p.Val578Met, so we considered that the mother inherited the Met allele of p.Val578Met from her maternal side and the His allele of p.Leu858His from her paternal side, therefore making her compound heterozygous for the two variants p.Val578Met and p.Leu858His. ", "Because the patient\\'s mother did not possess the Met allele of p.Thr60Met, we considered that the patient was almost certainly compound heterozygous for p.Thr60Met and p.Leu858His. ", "The patient father\\'s DNA was unavailable and therefore could not be genotyped.", "\n\nThe mother and maternal grandmother had no symptoms related to GS, and neither hypertension nor other abnormal findings suspicious for GS were pointed out in a regular medical checkup. ", "Blood gas analysis showed that the blood potassium levels and venous pH were within normal limits (4.0 and 4.2 mmol/L for blood potassium and 7.407 and 7.358 for venous pH, respectively; Table [1](#T1){ref-type=\"table\"}); however, the venous blood HCO~3~- levels were elevated (29.6 and 28.9 mmol/L, respectively; Table [1](#T1){ref-type=\"table\"}).", "\n\nDiscussion {#sec1_3}\n==========\n\nGS is an autosomal recessive disorder, and genetic testing of *SLC12A3* is useful to differentiate GS from other salt-losing nephropathies.", "\n\np.Thr60Met was categorized in ClinVar as a pathogenic variant and p.Leu858His as having conflicting interpretations (pathogenic and uncertain significance) \\[[@B6]\\]. ", "Both a functional study using a mammalian cell expression system and a familial study with GS supported the pathogenicity of p.Leu858His \\[[@B7], [@B8]\\], and the genotyping results of the GS family in the present study also support p.Leu858His as a pathogenic variant for GS.", "\n\np.Val578Met was reported to have an allele frequency of 0.62% in the Japanese general population \\[[@B9]\\] and was categorized as of unknown significance in ClinVar \\[[@B6]\\]. ", "Previously, a patient with GS was reported who possessed the same genotype as the mother of the present case \\[[@B10]\\]. ", "Although the mother showed features against a diagnosis of GS (i.e., absence of hypokalemia without renal failure) \\[[@B1]\\] and did not have GS-related symptoms such as muscle cramps and weakness, she did show an elevated level of HCO~3~- (Table [1](#T1){ref-type=\"table\"}). ", "p.Ala569Val was reported to have an allele frequency of 0.46% in the Japanese general population \\[[@B9]\\] and is also categorized as of unknown significance in ClinVar \\[[@B6]\\]. ", "Individuals carrying the same genotype as the grandmother of the present case have also been reported \\[[@B11]\\], but the grandmother of the present case also showed features against a diagnosis of GS, except for the level of HCO~3~- (Table [1](#T1){ref-type=\"table\"}).", "\n\nFujimura et al. ", "\\[[@B11]\\] investigated the *SLC12A3* mutations, clinical symptoms, and diagnostic opportunities of 185 Japanese GS patients. ", "The allele frequencies of 4 variants in the general Japanese population (*n* = 3,552) \\[[@B9]\\] and those in the 185 GS patients \\[[@B11]\\] are shown in Table [2](#T2){ref-type=\"table\"}. ", "Although not directly comparable, the difference in the allele frequencies of the variants found in the current patient (p.Thr60Met and p.Leu858His) between the general Japanese population and Japanese GS patients was much greater than that found only in the grandmother and the mother (p.Ala569Val and p.Val578Met).", "\n\nIn the study of Fujimura et al. ", "\\[[@B11]\\], more than half of the diagnostic opportunity for GS was a chance blood test for diagnostic purposes other than for GS. ", "Our data indicate that some suspected pathogenic variants such as p.Ala569Val and p.Val578Met may not be sufficient to cause phenotypic changes related to GS (i.e., hypokalemia). ", "The blood HCO~3~- levels of the mother and the grandmother and the pCO~2~ level of the grandmother were elevated (Table [1](#T1){ref-type=\"table\"}). ", "Whilst the serum potassium level is included in many routine blood tests, the blood gas levels are not. ", "Therefore, GS is not suspected if there is no abnormality in the blood potassium levels. ", "No respiratory symptoms or respiratory diseases had been noticed in the mother or the grandmother, and it is possible that respiratory compensation or compensation of channels in the kidney worked to adjust the blood pH level. ", "Also, the possibility cannot be denied that modifier genes are involved in the onset of GS or that phenotypic changes caused by the suspected pathogenic variants would be apparent later in life.", "\n\nNGS is an effective technology to detect pathogenic variants, especially in Mendelian diseases, and is now widely used for the diagnosis of diseases of unknown etiology. ", "The accumulation of more NGS data leads to increased numbers of variants of unknown significance, and many of those variants are very rare and sometimes unique to each individual \\[[@B12]\\]. ", "Recently, carrier frequencies of 11 recessive newborn screening diseases were estimated using Japanese whole genome reference panels, and the actual carrier frequencies of some diseases were found to depart from the calculated carrier frequencies based on the disease incidence rates \\[[@B13]\\]. ", "This departure may be due to inaccurate estimation of the functional effect of variants or to inaccurate diagnosis \\[[@B13]\\]. ", "Accumulation of genotype data with accurate phenotyping, including those of \"healthy\" or \"asymptomatic\" individuals in various ethnic populations, will improve the genetic diagnosis for GS patients.", "\n\nStatement of Ethics {#sec1_4}\n===================\n\nThis study was approved by the institutional review boards of the University of Tsukuba (H30-57) and Tokyo Medical and Dental University (G2000-80), and written informed consent for publication was obtained from all the participants.", "\n\nDisclosure Statement {#sec1_5}\n====================\n\nThe authors have no conflicts of interest to declare.", "\n\nFunding Sources {#sec1_6}\n===============\n\nThis work was supported by a Grant-in-Aid for Research Activity start-up from the Japan Society for the Promotion of Science.", "\n\nAuthor Contributions {#sec1_7}\n====================\n\nM. Ishikawa and H. Tanaka performed the experiments and drafted the manuscript. ", "Y. Tada designed the study and collected the clinical data. ", "W. Morii performed the data analysis. ", "M. Inaba and H. Takada critically reviewed and revised the manuscript. ", "T. Mori performed the experiments and critically reviewed and revised the manuscript. ", "E. Noguchi designed the study and revised the manuscript. ", "All the authors approved the final manuscript.", "\n\nWe thank all the members of the GS family who participated in this study. ", "We are also grateful to Flaminia Miyamasu for comments that greatly improved the manuscript.", "\n\n{#F1}\n\n{ref-type=\"fig\"}), heterozygous for p.Ala569Val (rs79351185) and p.Val578Met (rs139329616). ", "The red and blue circles indicate the positions of the p.Ala569Val (c.1706C\\>T) and p.Val578Met (c.1732G\\>A) variant sites, respectively.](cnd-0010-0071-g02){#F2}\n\n###### \n\nClinical laboratory data of the family with Gitelman syndrome\n\n Test Patient Mother Grandmother Ref. ", "range \n ---------------------- --------- -------- ------------- --------------------- ------------------------------------------------------------------------------------------------------\n *Blood gas (vein)* Ref. ", "range (artery) Comparison of venous blood gases to arterial values (approximately)[^a^](#T1F1){ref-type=\"table-fn\"}\n 7.463 7.407 7.358 7.35--7.45 0.03--0.04 pH units lower\n pCO2, mm Hg 41.8 48.0 52.8 35--45 3--8 mm Hg higher\n HCO3-, mmol/L 29.5 29.6 28.9 22--26 1--2 mEq/L higher\n \n *Blood electrolytes* \n Na+, mmol/L 133 142 142 139--146 \n Cl−, mmol/L 92 106 106 96--108 \n K+, mmol/L 2.8 4.0 4.2 3.5--5.0 \n Ca++, mmol/L 1.08 1.30 1.30 1.15--1.30 \n\nTheodore \\[[@B14]\\].", "\n\n###### \n\nAllele frequency of the *SLC12A3* variants found in the family with Gitelman syndrome\n\n Japanese, % (*n* = 7,104[^a^](#T2F1){ref-type=\"table-fn\"}) Japanese GS patients, % (*n* = 370[^b^](#T2F2){ref-type=\"table-fn\"})\n --------------------------- ------------------------------------------------------------ ----------------------------------------------------------------------\n rs371443644 (p.Thy60Met) 0.03 2.97\n rs79351185 (p.Ala569Val) 0.46 0.81\n rs139329616 (p.Val578Met) 0.62 1.08\n rs185927948 (p.Leu858His) 1.24 24.3\n\nThe allele frequencies of the variants in the Japanese population were from those of the Japanese Multi Omics Reference Panel (3.5KJPNv2), Tohoku University (<https://jmorp.megabank.tohoku.ac.jp>) \\[[@B13]\\].", "\n\nThe allele frequencies of the variants in the Japanese GS patients were from the study by Fujimura et al. ", "\\[[@B11]\\].", "\n\n[^1]: Moena Ishikawa and Yumi Tada contributed equally to this work.", "\n" ]

{ "pile_set_name": "PubMed Central" }

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[ "// Copyright (c) 2015 Elements of Programming Interviews. ", "All rights reserved.", "\n\n#include <cassert>\n#include <iostream>\n#include <limits>\n#include <random>\n#include <stdexcept>\n\nusing std::cout;\nusing std::default_random_engine;\nusing std::endl;\nusing std::exception;\nusing std::invalid_argument;\nusing std::numeric_limits;\nusing std::random_device;\nusing std::uniform_int_distribution;\n\nunsigned long LowestSetBit(unsigned long);\nunsigned long LowestUnsetBit(unsigned long);\n\n// @include\nunsigned long ClosestIntSameBitCount(unsigned long x) {\n if (x == 0 || x == numeric_limits<unsigned long>::max()) {\n throw invalid_argument(\"All bits are 0 or 1\");\n }\n unsigned long mask = (x & 1) == 0 ? ", "LowestSetBit(x) : LowestUnsetBit(x);\n mask = mask | (mask >> 1);\n return x ^ mask;\n}\n\nunsigned long LowestSetBit(unsigned long x) { return x & ~(x - 1); }\n\nunsigned long LowestUnsetBit(unsigned long x) { return LowestSetBit(x + 1); }\n// @exclude\n\nint CountBitsSetTo1(int x) {\n int count = 0;\n while (x) {\n x &= (x - 1);\n ++count;\n }\n return count;\n}\n\nvoid SmallTest() {\n assert(ClosestIntSameBitCount(6) == 5);\n assert(ClosestIntSameBitCount(7) == 11);\n assert(ClosestIntSameBitCount(2) == 1);\n assert(ClosestIntSameBitCount(32) == 16);\n}\n\nint main(int argc, char* argv[]) {\n SmallTest();\n default_random_engine gen((random_device())());\n unsigned long x;\n if (argc == 2) {\n x = atol(argv[1]);\n } else {\n uniform_int_distribution<int> dis(0, numeric_limits<int>::max());\n x = dis(gen);\n }\n try {\n unsigned long res = ClosestIntSameBitCount(x);\n cout << x << ' ' << res << endl;\n assert(CountBitsSetTo1(x) == CountBitsSetTo1(res));\n } catch (const exception& e) {\n cout << x << ' ' << e.what() << endl;\n }\n return 0;\n}\n" ]

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[ "Thank you Diana for the plug for my blog, I appreciate it a lot. ", "And Thanks to all who signed up, and decided to follow me.", "And if you like good writing, and Amish books, THE PROMISE OF AN ANGEL by Ruth Reid, is great.", "\n\nDumb Blond Yankee girl, no that wasn't exactly what I thought, Diana, when we first met. ", "I thought WHIRLWIND. ", "Love you 'sis'.", "\n\nYes,I've co written one book, I'm proud of it, but that was a few years ago, and I'm not sure I'm up to the challenge of another book. ", "Short stories are more my thing.", "\n\nDiana Kosmoski Author\n\nAvailable on Amazon\n\nWelcome\n\nHello, I'm Diana. ", "I am fun loving and tenderhearted. ", "I feel blessed to have a wonderful family that means the world to me. ", "God is good! ", "Family is first in my life. ", "I enjoy Reading, Writing, Gardening, Cooking, Decorating and being a Nana.", "\n\nFollow Me\n\n~~~~~Sweet Cheeks~~~~~\n\n~~~~Someday Her Prince Will Come~~~~~\n\nMy Hero's Cancer Journey\n\nStay Updated!", "\n\nSubscribe by email\n\nSign up with your email address to receive new updates straight in your inbox." ]

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[ "World Cup superfans travel thousands of kilometres and spend up to the thousands in euros, all to support their national team.", "\n\nEuronews chatted with some of the most dedicated supporters around Europe. ", "They tell us why — and how — they always cheer on their teams no matter the distance.", "\n\nWe spoke to Dan Lawson, an England supporter based in the US, who can't stop going to the matches despite the long distance.", "\n\nThe English fan living abroad who keeps flying back to Europe\n\nHe’s the England superfan who claims to have clocked up tens of thousands of air miles following his footballing heroes from the US. ", "Dan Lawson, who grew up in Farnborough, southern England, moved stateside six years ago. ", "The 28-year-old began a new life in New Jersey as a football coach but has found it hard to give up the old habits of supporting England.", "\n\nHe’s flown back to Europe for around 15 games since 2014 before picking up the bug for following the team away at Euro 2016 in France. “", "I’d probably describe myself more as a stupid fan [than a superfan] because of the money and the travelling,” he told Euronews.", "\n\n“I personally cannot give it up but my missus thinks I’m nuts and is begging me to save and buy a house and spend money on other stuff.”", "\n\nLawson said he will spend €5,700 on just getting to Russia for this summer’s football extravaganza.", "\n\n“I don’t even like to think about it [how much all the trips to watch England have cost me].", "\n\n“It’s because a lot of places are so difficult to get to. ", "I’m planning this trip now I have to fly from New York to Copenhagen, Copenhagen to Latvia, Latvia to Moscow and then Moscow to Volgograd.”", "\n\nSo what motivates him to go to such lengths to support his national team?", "\n\n“There isn’t an easy way to explain [what motivates me],” he said. “", "It’s just the buzz because generally, the football is not great. ", "The football is generally the low points of these trips!", "\n\n“I guess it’s experiencing new cultures and meeting other like-minded fans.", "\n\n“My missus thinks I’m a weirdo. ", "I have a couple of friends who are expats and I think they understand. ", "Friends that I meet from the US, it’s foreign to them as it is, so they definitely don’t understand.", "\n\n“I’ve regretted going plenty of times. ", "More often than not. ", "But I keep going back. ", "I said it after the Euros that I wouldn’t go to Russia. ", "But the closer it gets, it’s the eternal hope of an England fan that kills you every single time.”" ]

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[ "Q:\n\nIs it safe to access 'this' pointer from the second father as first father's pointer\n\nI have to admit that it's hard to express the question. ", "So I have example：\n\nclass P1\n{\npublic:\n P1(int num) : m_Num(num)\n {\n }\n\n int m_Num = 0;\n};\n\nclass P2\n{\npublic:\n P2(P1* ptr) { std::cout << ptr->m_Num << std::endl; }\n};\n\nclass S : public P1, public P2\n{\npublic:\n S(): P1(567), P2(this)\n {\n }\n};\n\nint main()\n{\n S abc;\n}\n\nActually you'll get the output like this:\n\n567\n\nBut I'm not sure whether safe to use ptr in P2 according to the standards.", "\n\nA:\n\nYes it's safe, at least in this case. ", "The key thing to note is that the standard allows to provide derived class pointer where base class pointer is expected. ", "In your code P2 is base and S is derived, passing S's pointer where P2's pointer is expected is absolutely legal.", "\nThis is related to polymorphism and supported by all OOP languages.", "\n\n" ]

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[ "Get involved\n\nBy joining forces with other organizations we increase not only our own, but the joint impact of our initiatives. ", "Please fill out the contact form if you are interested in partnering with us in any way, shape, or form and we'll get back to you as soon as possible!", "\n\nConnecting the world through free communication\n\nAuthor:\nMark VletterPublished on:5 June 2018\n\nIn 2003 I worked in Haiti for roughly six months. ", "Haiti is one of the poorest countries in the world. ", "After an 11-hour flight, you go from a country that has everything to a country that has nothing. ", "In Haiti, I saw what a lack of access to information and communication does to a country and its people.", "\n\nToday, 48% of the world’s population still has no access to free communication. ", "This needs to change. ", "With 48percent.org we want to bring equality to the world by enabling that last 48% to have access to unrestricted communication.", "\n\nThe plan to make this happen\n\nThere were a number of basic essential conditions for us to be able to make this a reality: a strong income stream, being a communication authority, and a scalable self-reliant organization. ", "Now that these conditions are met, we can get started on building the solution. ", "We believe this solution consists of roughly three parts:\n\n1. ", "You need a data network. ", "These can be balloons, low orbitsatellite networks or drones that bring that data network to remote areas.2. ", "Then you need a base station that translates the signal from these data networks into a local network.3. ", "Finally, you must have devices that use this local network.", "\n\nThat’s easy, right?", "\n\nIt sounds simple and achievable, but unfortunately, it is not. ", "The big bottleneck is electricity. ", "Approximately 15% of the world’s population has no access to electricity, and things like WiFi and 4G demand a lot of it. ", "A new generation of networks and receivers that are much more energy efficient needs to be built. ", "Only then can the 48 percent of the world that does not yet have access to free communication be brought online.", "\n\nThe need for a reliable network\n\nBut with electricity alone, you are not there yet. ", "A reliable network also has to be set up. ", "This network is preferably an open source and crowd owned network. ", "Any node added to the network can then be both a receiver and a transmitter. ", "This makes the network independent of commercial parties and even of government authorities. ", "Developing this network circularly also keeps the impact this project has on the planet to a minimum.", "\n\nThe 48percent.org foundation\n\nIn recent years we have developed the building blocks to be able to build the above framework. ", "Now is time to stack those blocks! ", "We’re very excited for this to happen and we are setting up a foundation for this purpose: 48percent.org.", "\n\nThe mantra of this foundation is:\n\n“Bring equality to the world by enabling everybody to have access to unrestricted communication”\n\nThe first step is to promote the development of the components needed for open communication. ", "We don’t have to do all of this ourselves, but we love to boost the process.", "\n\nGenerating power: the Lightyear One\n\nThe decentralized generation of power is a very important component to make it all possible. ", "Looking at the latest technology, we already made a promising first purchase: we bought the Lightyear One. ", "This solar car decentrally generates its own electricity and stores it in small batteries while giving an unmatched range for the capacity of these batteries. ", "The team that developed the car has access to the networks that can make the solar and battery technology scalable and works, just like us, purpose-driven." ]

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[ "06 January 2010\n\nHealthcare corner #1 - A student again\n\ni get to audit the course my boss is teaching this semester.", "\n\nshe teaches the \"Intro to Health Services Research and Policy\" course in the community health and epidemiology department of dalhousie universitys medical school. ", "its all about the canadian health care system. ", "the goal is to give students an understanding of all parts of the system as well as to be able to identify/accurately discuss/critically think about the important hot-button issues related to the system. ", "as you can imagine, this would be immensely useful for engaging an american in discussion about their health care debate/situation.", "\n\nour class is pretty large (18 people. ", "which is large here.) ", "and most of the students are from the maritime provinces, with a few of them coming from ontario. ", "i am the only american. ", "i am seriously intrigued to see how the course and discussions pan out. ", "so, i thought i might share some of the new things i learn and some new opinions i hear each week. ", "nothing too lengthy, just little blurbs to stimulate your mental juices. ", "not meant to insight political attacks or rage.", "\n\nso today, as with all first days of class, most class time was spent pouring over the syllabus. ", "then we had time for a very general health care system overview. ", "to get us discussing, my boss showed a video (sponsored by patients united now) that was made a couple years ago in the u.s. ", "that featured a canadian woman who came to the u.s. ", "for treatment because, she says, her health care system failed her.", "\n\ni had heard of the video/commercial but hadnt seen it, its quite short but enough to coax discussion from even the most shy of people. ", "there are some important facts left out of her story (that she actually had a benign pituitary gland tumor, not life-threatening cancer. ", "that she mortgaged her house to pay for the $100,000+ surgery at mayo clinic.) ", "that would have been useful for accuracy, and there are also some gross, sweeping statements about canada that are inflammatorily false (that it denies citizens care. ", "that the government says \"patients arent worth it\" as reasoning to deny coverage of certain drugs/treatments).", "\n\nas you can imagine, the students had some opinions. ", "and all seemed to want to be able to have the hard facts and indisputable evidence to use to put all the false information or insinuations in the ad to bed, for good. ", "interestingly, several mentioned the 'general opinion' that \"canadians have a more community focus. ", "we want a system to work for everyone. ", "we understand that means that those of us who are able to wait, do so, and leave space for more urgent cases to get taken care of. ", "its something we will take advantage of when/if its our time. ", "americans have a much more individualistic approach. ", "they see things as 'its my right to get treated when i want and how i want. ", "if i have the money, i should be able to get what i want now.'\" (", "i am paraphrasing of course, but these are the condensed ideas i heard in class, and have heard from other discussions previously). ", "of course this 'general opinion' is just that. ", "with alberta being the wealthiest canadian province, i am told that many of those citizens have views more closely in line with the presumed 'american opinion.' ", "but, there you have some of the tidbits from the first class period.", "\n\nNo comments:\n\ncurrently living in helsinki, finland\n\nthis blog is about life since leaving michigan. ", "my husband and i left our home state in 2008 for jobs, travel, and adventure. ", "together we've lived in ann arbor for 9 years, france for 9 months, halifax for 3.5 years, and we've now lived in finland for 2.5 years. ", "our daughter (X) joined us in 2010, and our son (Y) joined us in 2014, so they are now part of the adventure..." ]

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[ "OEM For iPad 3 digitizer assembly, this assembly already has home button assembly, front camera bracket and bonding adhesive fitted in place making it the easier solution to replace your existing digitizer\n\nOEM For iPad 3 digitizer assembly, this assembly already has home button assembly, front camera bracket and bonding adhesive fitted in place making it the easier solution to replace your existing digitizer\n\nOEM For iPad 3 digitizer assembly, this assembly already has home button assembly, front camera bracket and bonding adhesive fitted in place making it the easier solution to replace your existing digitizer" ]

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[ "Q:\n\nExporting table from MySQL and importing to Google sheet\n\nI want to export one table from MySQL to a Google sheet. ", "I am working in Java environment and MySQL Workbench. ", "Is there anyway to achieve this?", "\nSuppose I have a table by the name Student which has following columns:\nStudent\n------------------------------------------------------\n ID NAME RollNo.", "\n------------------------------------------------------\n\n 1 abc 111\n 2 xyz 222\n 3 lmn 333\n------------------------------------------------------\n\nI just want to export ID and NAME columns from the above table to a google sheet.", "\n\nA:\n\nHave you looked at =IMPORTRANGE()\nIt might be what you're looking for. ", "Here is the documentation. ", "\nI use it quite often to pull an SQL database into Google sheets.", "\n\n" ]

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[ "Talkbox episode has some personality for you! ", "One might say too much since we cut it into two. ", "In part one, we have Artem Lobov and Davis Feldman promoting the big move to Bare Knuckle Fighting Championship. ", "Artem shows off just a smidge of personality while Davis shares big plans for the promotion.", "\n\nThe podcast goes from 0 to 100 and then back to a calming tone with the great Art Lovely joining the podcast! ", "What still excites the soon to be 91 year old friend of the podcast? ", "Listen in and soak up some wisdom from this insightful conversation.", "\n\nLast, but not least, in part one of this episode is 9-0 female fighter out of Mexico, Sulem Urbina. ", "Sulem has some good answers for Mike when asked about the pressures women have in fighting and also gives an update of what promising land her career is headed towards." ]

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[ "Q:\n\nHow to delete a disk partition that remains after I introduce a stick?", "\n\nI have the following problem on my computer:\nEvery time I connect a USB memory stick to my computer it is assigned a drive letter, and this does not go away when I disconnect the memory stick. ", "You can see below that my File Explorer shows a large number of entries for USB memory sticks that are no longer connected to the computer. ", "\nHow do I make these go away? ", "\n\nA:\n\nI assume it is a drive letter issue in Windows 10.", "\nThere is a similar post on the microsoft forum.", "\nSolution:\n\nRight Click each non-existent drive one at a time and select Properties.", "\nWhen the Properties opened there are the General, DVD Region, Volumes, Driver, Details and Events tabs. ", " Click the Driver tab and then select Disable. ", " After selecting Disable the \"are you certain you want to do this\" dialog appears and on this screen I selected Yes.", "\n\nAfter performing the above the entire problem was resolved. ", " Then when inserting random Jump Drives the USB Drive letter populated. ", " Remove the Jump Drive and the Drive is no longer present in both File Explorer and Disk Management.", "\n\n" ]

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[ "Rapeseed (*Brassica napus* L., 2n = 38, genome AACC) is one of the most important oilseed crops worldwide. ", "Branch angle, or the adaxial angle of the branch to the stem, is a key morphological trait that shapes the canopy architecture and thus influences yield. ", "This notion is best exemplified through the continuous increase in grain yield of US corn over the past century, which reflects the adaptation of hybrid upper leaf angles that continually increase plant densities[@b1]. ", "Plants with adequately small branch angles display compact canopy architectures, and these plants are therefore more suitable for high-density planting. ", "Furthermore, at later growth stages, siliques replace leaves as the main photosynthesis organ[@b2], so a compact canopy architecture maintains light capture under high densities by minimizing shading by adjacent plants. ", "Accordingly, clarifying the genetics determining branch angles will be of great value for continuous improvements in rapeseed architecture.", "\n\nBranch angles are primarily regulated through shoot gravitropism, which is also referred to as the gravitropic set-point angle (GSA)[@b3] and includes four phases: gravity perception, gravity signal transduction, auxin asymmetric redistribution, and organ curvature[@b4]. ", "To date, numerous genes that influence branch (tiller) angle have been identified in model plants. ", "For example, *Arabidopsis* genes *sgr1-sgr9* cause attenuation of the shoot gravity perception capacity and alter branch angles[@b5]. *", "LAZY1* has been implicated in the regulation of the rice tiller angle, and loss of *LAZY1* function alters the distribution of endogenous IAA in the shoot, which reduces shoot gravitropism and leads to a tiller-spreading phenotype[@b6]. ", "A recent study has also identified a role for the *Arabidopsis LAZY1* orthologue in branch angle regulation[@b7]. *", "TAC1*, another branch (tiller) angle gene that was first identified in rice[@b8], is derived from the same *IGT* gene family as *LAZY1*[@b9] and recent studies have suggested that orthologues of *TAC1* control branch angles in *Arabidopsis* and peach[@b9]. ", "Moreover, a recent study in *Arabidopsis* showed that mutants with defects in auxin homeostasis or auxin response genes, such as *wei8 tar2*, *tir1-1*, *afb4-2 afb5-5*, and *arf10-3 arf16-2*, have altered branch angles[@b10]. ", "However, despite the increasing understanding of branch angle mechanisms in model plants, the genetic basis of branch angle in rapeseed has not been elucidated, a situation that reflects the complexity of genetic studies of polyploid plants.", "\n\nA genome-wide association study (GWAS) provides a methodical analysis of the genetic architecture of complex traits in crops. ", "GWAS identifies the underlying QTLs at a relatively high resolution, taking full advantage of ancient recombination events[@b11][@b12]. ", "To date, GWAS has been successfully performed in many crops, including rice[@b13], maize[@b14][@b15] and rapeseed[@b16][@b17][@b18]. ", "Among the proposed statistical approaches for GWAS, the mixed linear model (MLM) is a popular method that can eliminate the excess of low *p*-values for most traits[@b19][@b20]. ", "However, MLM can lead to false negatives by overcompensating for population structure and kinship[@b21], and MLM has also limited statistical power to detect rare alleles, which in fact constitute a substantial proportion of the natural variation[@b22] and have potentially large phenotypic effects[@b23]. ", "Accordingly, a complementary strategy, the Anderson-Darling (A-D) test, has recently been proposed to rectify these shortcomings[@b24]. ", "The A-D test is a novel nonparametric statistical method that offers a higher power than MLM for traits that have abnormal phenotypic distributions and are controlled by moderate effect loci or rare variations[@b24].", "\n\nIn the present study, we investigated correlations between the angles of branches at different positions and between these angles and other important agronomic traits. ", "Genome-wide SNPs of this panel were assessed using the 60K *Brassica* Infinium^®^ SNP array, and the corresponding phenotype was evaluated in four environments. ", "GWAS was performed with 520 diverse accessions to identify underlying QTLs that contribute to rapeseed branch angle variations. ", "A total of 56 loci that were significantly associated with the branch angle trait were identified by three association methods: MLM, the general linear model (GLM) and the A-D test. ", "Considerable candidate genes were identified based on LD decay range of these loci, including multiple orthologues of well-characterized *Arabidopsis* genes. ", "This study demonstrates that GWAS can be used as an effective approach for dissecting complex quantitative traits in rapeseed.", "\n\nResults\n=======\n\nPhenotypic variations in branch angle among accessions\n------------------------------------------------------\n\nHigh positive correlations were observed among the angles of different branches, indicating similar genetic control ([Table 1](#t1){ref-type=\"table\"}). ", "In general, the correlation coefficient between branches was reduced with decreasing physical proximity. ", "For example, the angle of the second branch from the top showed a maximum correlation with the angle of the third branch (r = 0.72) and then with the fourth and fifth branches (r = 0.61, 0.53, respectively). ", "In addition, we observed that the average angle of a different number of branches from the top was significantly positively correlated with the average angle of all branches, particularly when the branch number reached five (r = 0.93, [Table 1](#t1){ref-type=\"table\"}). ", "Thus, it is feasible to measure the five top branches as a representation of the branch angle phenotype. ", "Phenotypic data for 30 individual plants are presented in [Supplementary Data S1](#S1){ref-type=\"supplementary-material\"}.", "\n\nWe collected phenotypic data for the association panel in four environments; the trial performed at the Changsha farm was the only trial with phenotypic data across two growing seasons ([Table 2](#t2){ref-type=\"table\"}). ", "Extensive phenotypic variations were observed for branch angles in the association panel, as indicated by the descriptive statistics shown in [Table 2](#t2){ref-type=\"table\"}. ", "In the four environments, the branch angle varied from 21.7 ± 1.9° to 71.7 ± 4.8°, with an average ranging from 40.3 ± 6.3° to 43.2 ± 6.3°. ", "The coefficient of variation was constant in the different environments and ranged from 14.5% to 16.2%. ", "The phenotypic data for all accessions in the four environments as well as BLUP values are presented in [Supplementary Data S2](#S1){ref-type=\"supplementary-material\"}.", "\n\nThe branch angles of the association panel in the four environments exhibited significantly positive correlations with each other, indicating the reliability and repeatability of these phenotypic data ([Supplementary Table S1](#S1){ref-type=\"supplementary-material\"}). ", "Analysis of variance (ANOVA) revealed that the genotype, environment (year and location) and genotype × environment interaction all had significant effects on the branch angle, suggesting the crucial influence of environment on branch angle regulation ([Supplementary Table S2](#S1){ref-type=\"supplementary-material\"}). ", "Based on phenotypic data for the four environments, the broad-sense heritability of the branch angle was as high as 78.5%.", "\n\nWe then analysed the relationship between the branch angle and other important agronomic traits (only data for 2012/2013 and 2013/2014 at Changsha were available for these traits). ", "Notably, branch angle was significantly positively correlated with plant height, which had the highest coefficient (r = 0.25, 2012/2013 Changsha), followed by branch number (r = 0.17, 2012/2013 Changsha, [Table 3](#t3){ref-type=\"table\"}). ", "Moreover, significant positive correlations were also observed between the branch angle and four yield-related traits, including the main inflorescence pod number, pod length, seed number per pod and seed yield (2012/2013 Changsha, [Table 3](#t3){ref-type=\"table\"}). ", "Similar results were observed in the 2013/2014 Changsha phenotypic data ([Supplementary Table S3](#S1){ref-type=\"supplementary-material\"}). ", "Therefore, the results indicated a close relationship between branch angle and multiple plant-type and yield-related traits.", "\n\nSNP performance, quality and in silico mapping\n----------------------------------------------\n\nThe Illumina *Brassica* 60K Infinium^®^ SNP array was used to genotype 530 rapeseed accessions. ", "The raw data generated using the Illumina Infinium platform were further analysed with Genome Studio software by cluster refinement with an optimum accession Call Rate \\> 0.7; SNP Call Freq \\> 0.75; Minor Freq \\> 0.05; AA, BB frequency \\> 0.03; and GenTrain Score \\> 0.5. ", "Through this analysis, 520 accessions and 33,218 polymorphic SNPs (63.7%) were retained. ", "After excluding SNPs lacking clearly defined clusters or with multiple loci in the genome, 19,167 high-quality SNPs (36.7%) genotyped across 520 rapeseed accessions were utilized for association mapping. ", "The genotyping scores for all polymorphic SNPs are presented in [Supplementary Data S3](#S1){ref-type=\"supplementary-material\"}.", "\n\nPopulation structure and linkage disequilibrium\n-----------------------------------------------\n\nThe population structure of the association panel was calculated for the 19,167 SNPs using STRUCTURE, and the parameters LnP(D) and Delta K suggested that the 520 genotypes could be assigned to two groups. ", "A probability of membership threshold of 0.60 was used, and 65 and 398 lines were assigned to Groups 1 and 2, respectively, with the remaining 57 lines classified into a mixed group ([Supplementary Data S4](#S1){ref-type=\"supplementary-material\"}). ", "In addition, the lm procedure in R showed that population structure accounted for 15.8% of the phenotypic variation of branch angle. ", "The data for population structure and kinship are presented in [Supplementary Data S5](#S1){ref-type=\"supplementary-material\"}.", "\n\nWhen r^2^ = 0.1, seven chromosomes (A01 to A07) exhibited comparatively modest LD, with distances ranging from 708 to 873 kb ([Fig. ", "1](#f1){ref-type=\"fig\"}, [Supplementary Table S4](#S1){ref-type=\"supplementary-material\"}). ", "Chromosomes A09, C03, C05, C06 and C09 showed stronger LD, with distances ranging from 1,039 to 2,968 kb. ", "However, particularly reinforced LD patterns were observed for chromosomes A08, A10, C01, C02, C04, C07 and C08, which presented a corresponding LD decay ranging from 4,264 to 8,704 kb. ", "Consistent with the performance of the major A chromosomes, the A subgenome exhibited modest LD, with a distance of up to 1,046 kb, whereas the C subgenome exhibited extremely conserved LD of 7,882 kb when r^2^ = 0.1. ", "The average LD decay for the entire genome was 6,660 kb when r^2^ = 0.1 ([Supplementary Fig. ", "S1, Supplementary Table S4](#S1){ref-type=\"supplementary-material\"}).", "\n\nGenome-wide association study\n-----------------------------\n\nWhen we initially performed GWAS with MLM using BLUP values across four environments, 19 SNPs significantly associated with branch angle were identified at a threshold of *p* \\< 5.2 × 10−5 (1/19,167, −log10(*p*) = 4.3); these sites correspond to 12 loci located on chromosomes A03, A04, A09, C04, C07 and C08 ([Table 4](#t4){ref-type=\"table\"}, [Fig. ", "2](#f2){ref-type=\"fig\"}). ", "Using the phenotypic data for the individual environments, MLM identified 4 additional loci on chromosomes A07, A10, C05 and C09 under the same threshold as indicated above ([Table 4](#t4){ref-type=\"table\"}). ", "Altogether, these 16 loci explained 40.3% of the total phenotypic variance.", "\n\nTo better utilize the genotyping and phenotyping information obtained in the present study, two permissive models, GLM and the A-D test, were introduced into our association analysis. ", "Briefly, the two models detected 48 (GLM) and 24 (A-D test) loci significantly associated with BLUP and individual environmental data at the corresponding Bonferroni threshold, values of −log~10~(*p)* = 4.3 for GLM and −log~10~(*p)* = 5.6 for the A-D test ([Table 4](#t4){ref-type=\"table\"}, [Fig. ", "2](#f2){ref-type=\"fig\"}). ", "We then compared the consistency of the loci identified among the three methods. ", "All loci detected using MLM were repeatedly detected through either GLM or the A-D test, and four loci were consistently detected across all three models, including Bn-A03-p6228570 on A03, Bn-A04-p4410144 on A04, Bn-A07-p13172047 on A07 and Bn-scaff_16062_1-p345501 on C05 ([Table 4](#t4){ref-type=\"table\"}). ", "A total of 16 associated loci were consistently detected between GLM and the A-D test, whereas 20 and 8 loci were exclusive to GLM and the A-D test, respectively ([Table 4](#t4){ref-type=\"table\"}). ", "Altogether, the three methods identified 56 unique loci significantly associated with the branch angle trait. ", "Except for C01, these loci are unevenly distributed over all chromosomes. ", "A03 and A07 both have a maximum of 10 loci, A04 and C08 five loci, and A10 and C03 three loci. ", "The remaining chromosomes have either one or two loci ([Table 4](#t4){ref-type=\"table\"}). ", "Approximately two-thirds of the loci (38/56) are distributed in the A subgenome; the remaining loci are distributed in the C subgenome. ", "When using a simple additive model, the 56 loci explained up to 51.1% of the phenotypic variation.", "\n\nCandidate gene mining\n---------------------\n\nWhen using the whole genome genes as reference, two categories of genes, genes with auxin efflux transmembrane transporter activity (GO:0010329) and genes with auxin transmembrane transporter activity (GO:0080161), were found to enrich in the LD decay ranges of significant loci (false discovery rate \\< 0.05, [Supplementary Fig. ", "S3](#S1){ref-type=\"supplementary-material\"}, [Supplementary Data S6](#S1){ref-type=\"supplementary-material\"}). ", "Based on the GO annotation, *Arabidopsis* orthologue information and published gravistimulation microarray data, we further predicted candidate causal genes for loci significantly associated with the branch angle trait within the observed LD decay (r^2^ \\> 0.1), with 77 plausible candidate genes predicted for 53 loci. ", "Due to the low rate of LD decay (776.8 kb on average when r^2^ = 0.1), more than one-third of the GWAS loci (20/53) have at least two candidate genes ([Supplementary Data S7](#S1){ref-type=\"supplementary-material\"}). ", "For example, three candidate genes, *BnaA01g12950*, *BnaA01g13320* and *BnaA01g13580*, which are orthologous to *Arabidopsis CRK5*[@b25], *ARF9*[@b26] and *TRH1*[@b27], were collectively identified within the LD decay of the GWAS locus Bn-A01-p7430311 (r^2^ \\> 0.2, [Supplementary Data S7](#S1){ref-type=\"supplementary-material\"}). ", "Briefly, 48 (62.3%) candidate genes are related to auxin asymmetric redistribution, and 10 (13.0%), 5 (6.5%), and 5 (6.5%) candidate genes are involved in gravity perception, gravity signal transduction and organ curvature, respectively ([Supplementary Data S7](#S1){ref-type=\"supplementary-material\"}). ", "The remaining nine genes (11.7%) are associated with ROS, phototropism, ethylene, and strigolactone ([Supplementary Data S7](#S1){ref-type=\"supplementary-material\"}).", "\n\nIn Arabidopsis, *sgr1*-*sgr9* represent a series of defective shoot gravity perception mutants with abnormal branch angles[@b5]. ", "The vacuolar membrane dynamics of the stem gravity-sensing cells of the *sgr2*, *sgr3*, *sgr4* and *sgr8* mutants are abnormal and affect the sedimentable movements of statoliths (amyloplasts)[@b5]. ", "In the *sgr9* mutant, interaction between statoliths and actin filaments is perturbed, resulting in attenuated statolith sedimentation[@b28]. ", "In the present study, two orthologues of *SGR4*, *BnaA04g09380* and *BnaC04g31610*, are located at 8.4 Mb on A04 and 33.4 Mb on C04, 205.4 kb downstream from the peak SNP Bn-A04-p6929056 and 370.9 kb upstream from the peak SNP Bn-scaff_16876_1-p1162532, respectively ([Supplementary Data S7](#S1){ref-type=\"supplementary-material\"}). ", "We also identified an orthologue of *SGR2* at 13.6 Mb on C08, which is 302.7 kb downstream from the peak SNP Bn-scaff_16468_1-p450133 ([Supplementary Data S7](#S1){ref-type=\"supplementary-material\"}). ", "In addition, the *SGR9* orthologue *BnaA10g26980* was identified at 17.1 Mb on A10, 132.8 kb upstream from the peak SNP Bn-A10-p17414621 ([Supplementary Data S7](#S1){ref-type=\"supplementary-material\"}). ", "Notably, the loci harbouring the *SGR4* orthologue on C04 and the *SGR9* orthologue on A10 were both identified by stringent MLM. ", "In addition, the orthologues of *Arabidopsis SGR3* and *SGR5* were detected within the LD decay of the SNPs at 18.1 Mb on A02 and 22.7 Mb on A06 by using the A-D test, respectively, though the corresponding signals were not significant (−log~10~(*p*) = 4.6 \\< 5.6, −log~10~(*p*) = 4.8 \\< 5.6).", "\n\n*LAZY1* is a well-characterized gene that modulates branch (tiller) angles in plants. ", "The *Arabidopsis* mutant *lazy1* exhibits a dramatically increased branch angle of up to 81°, as compared to the 42° branch angle of wild-type plants[@b7]. ", "In the present study, *BnaA10g19550* and *BnaC03g06250*, two orthologues of *LAZY1* in rapeseed, were identified at 13.9 Mb on A10 and 3.0 Mb on C03, respectively, in close proximity (3.8 kb and 27.2 kb, respectively) to their corresponding peak SNPs Bn-A10-p13818569 and Bn-scaff_18936_1-p472353 ([Supplementary Data S7](#S1){ref-type=\"supplementary-material\"}, [Fig. ", "2](#f2){ref-type=\"fig\"}). ", "The orthologues of another well-known branch (tiller) angle gene *TAC1*, were also detected within the LD decay of SNPs at 0.7 Mb on A05 and 0.6 Mb on C04 by using GLM and the A-D test, respectively, though the signals were not significant (−log~10~(*p*) = 2.8 \\< 4.3, −log~10~(*p*) = 4.0 \\< 5.6).", "\n\nA recent study in *Arabidopsis* showed that mutants with defects in auxin homeostasis or auxin response genes, such as *wei8 tar2*, *tir1-1*, *afb4-2 afb5-5*, *arf10-3 arf16-2*, have altered branch angles[@b10]. ", "In the present study, *BnaA07g19520*, which is orthologous to the auxin receptor *TIR1*, was identified at 15.6 Mb on A07, 74.7 kb downstream from the peak SNP Bn-A07-p13662635 ([Supplementary Data S7](#S1){ref-type=\"supplementary-material\"}). ", "The orthologues of another auxin receptor *AFB5* and the auxin biosynthesis gene *TAR2*, *BnaA01g13890* and *BnaA01g14030*, were identified at 7.0 Mb on A01, 107.5 kb and 30.5 kb upstream, respectively, from the peak SNP Bn-A01-p7974551 ([Supplementary Data S7](#S1){ref-type=\"supplementary-material\"}). ", "We also identified the orthologue of *ARF10*, *BnaA07g13830*, at 12.2 Mb on A07, which is 118.2 kb downstream from the peak SNP Bn-A07-p10869578 ([Supplementary Data S7](#S1){ref-type=\"supplementary-material\"}). ", "In addition to the abovementioned candidate genes, we identified other candidate genes orthologous to documented *Arabidopsis* genes involved in auxin homeostasis or signalling pathways, such as *ARF10*, *AXL1*, *RUB1*, *ARF9*, *IAA13*, *IBR10*, *ILL2*, *SAUR30*, *SAUR60*, *GSL8*, *ABCB1*, *ABCB14*, *ABCB19*, *ABCB21*, *WAT1*, *PIN3*, *PIN7*, *APD7*, *HA1*, *HA2*, *CRK5*, *VAMP714*, *UGT74D1* and *UGT84B1* ([Supplementary Data S7](#S1){ref-type=\"supplementary-material\"}). ", "Moreover, the loci harbouring the *VAMP714*, *SAUR30* and *UGT74D1* orthologues on A03, the *IBR10* orthologue on A04, the *ABCB14* orthologue on C05 and the *ABCB19* orthologue on C09 were identified by MLM ([Supplementary Data S7](#S1){ref-type=\"supplementary-material\"}, [Fig. ", "2](#f2){ref-type=\"fig\"}).", "\n\nDiscussion\n==========\n\nThe ideotype theory has prompted crop geneticists to map and clone plant type-related QTLs. ", "To date, several genes that control the rice tiller angle, including *LAZY1*[@b6], *TAC1*[@b8] and *PROG1*[@b29], have been cloned in biparental segregating populations. ", "Because of the limited genetic diversity between two parents, natural populations or nest association mapping (NAM) populations have been developed to identify more favourable genes for plant-type traits. ", "Tian *et al.* ", "performed GWAS and joint linkage mapping of leaf traits, including the leaf angle trait, in maize NAM populations derived from 25 founder lines. ", "A total of 203 significant SNPs and 30 QTLs were identified, including the known genes *LG1* and *LG2*[@b15]. ", "Huang *et al.* ", "conducted GWAS of various traits, including the tiller angle trait, using 446 diverse *O. rufipogon* accessions. ", "Several loci, including the well-characterized major gene *PROG1*, were detected by using the stringent compressed MLM model[@b13]. ", "In the present study, we performed GWAS in 520 diverse rapeseed accessions to reveal the QTLs affecting the branch angle trait. ", "Based on the results of GWAS and GO annotation, we identified 77 plausible genes underlying the abundant phenotypic variation, including orthologues of well-characterized *Arabidopsis* genes, such as *SGR2*, *SGR4*, *SGR9*, *LAZY1*, *TIR1*, *AFB4*, *PIN3* and *PIN7*.", "\n\nThe phenotypic data obtained for branches at different positions enabled us to determine the branch(es) that provide the most reliable representation of the branch angle phenotype. ", "High correlation (r = 0.93) was observed between the average angle of five branches from the top and the average angle of all branches, and measuring only these five branches rather than all branches would reduce the time required to perform such an evaluation and preclude confounding due to the variable branch numbers of different plants. ", "Our statistical analyses revealed that plant height and branch angle are positively correlated, suggesting that shorter accessions tend to accompany a more compact canopy architecture. ", "In addition, we also observed positive correlations between plant-type traits and yield-related traits. ", "These results are informative to breeders attempting to adapt branch angles to achieve the ideal canopy architecture and high yields.", "\n\nThe association panel examined in the present study exhibited a strong LD of up to 6,660 kb (1,046 and 7,882 kb for the A and C subgenomes) at a cut-off value of r^2^ = 0.1, which can be explained by three possible reasons. ", "First, the often cross-pollination habit of rapeseed (natural outcrossing rate of 10--30%) could partially account for this phenomenon, as limited recombination from inadequate outcrossing is insufficient to break strong LD. ", "The similar phenomenon has been observed in crops with low natural outcrossing rate, such as rice, which showed residual LD at a distance of 2,000 kb[@b21]. ", "Second, the majority of accessions in the present association panel are Chinese elite breeding accessions; therefore, strong artificial selection for certain traits, such as punctual flowering time, high yield, and low erucic acid and glucosinolate levels, has exerted strong selective sweeps on the flanking regions of favourable genes and consequently has caused strong LD. ", "Similar phenomena have been observed in maize, with LD decay ranging from less than 1 kb in landraces[@b30] to more than 100 kb in elite breeding lines[@b31]. ", "Third, the \"founder effect\" could also account for the strong LD in our association panel. ", "According to Liu *et al.*, *", "B. napus* was first introduced to China from Japan and Europe in the 1930--1940s[@b32], and 97.3% of the certified cultivars from 1953 to 1982 were derived from one Japanese cultivar Shengli (based on a report published in Chinese in 1985). ", "In addition, to lower seed erucic acid and glucosinolate contents, several cultivars carrying the corresponding favourable alleles from Canada or Europe, including Oro, Tower, Midas, Marnoo and Reyent, were introduced to China as the main donor parents for crossing with local elite lines. ", "A partial estimate indicated that more than 39.7% of the 63 certified low erucic acid or glucosinolate cultivars from 1985 to 1996 are directly derived from these donor parents[@b33]. ", "Consequently, the \"founder effect\" may have caused the strong LD observed in our association panel. ", "Furthermore, the last two explanations might also be responsible for the stronger LD observed in our association panel as compared to that of several reported *B. napus* populations[@b34][@b35][@b36].", "\n\nThe 56 GWAS loci in the present study cumulatively explained up to 51.1% of the phenotypic variation when using a simple additive model. ", "Interestingly, despite the numerous significant SNPs identified, none of them explained more than 7.0% of the phenotypic variation. ", "The significant SNPs identified by GLM and MLM explained 2.6--6.6% and 3.2--6.0% of the phenotypic variation, respectively ([Table 4](#t4){ref-type=\"table\"}). ", "Similar genetic architectures have been observed for other complex traits, such as maize leaf angle, whereby 96.0% of the 30 significant QTLs had less than a 2.5° effect[@b15]. ", "In addition, the 29 large branch angle lines in the association panel have favourable alleles for 32.8 ± 5.6 (±SD) of the 56 loci associated with branch angle, whereas the 27 small branch angle lines have 17.9 ± 4.9 (±SD) favourable alleles ([Supplementary Fig. ", "S2](#S1){ref-type=\"supplementary-material\"}). ", "Accordingly, these results suggest that the observed large differences in branch angle among inbred rapeseed lines are not caused by merely a few genes with large effects, but rather by the cumulative effects of numerous QTLs having only small individual impacts on the trait.", "\n\nIn the present study, three methods (MLM, GLM and the A-D test) were collectively applied to dissect the genetic architecture of branch angle. ", "Considerable GWAS loci (described in the Results) overlapped between the methods; however, we also observed variations in the power and applicable scenarios of these three methods. ", "Compared with GLM and particularly MLM, the A-D test showed two advantages. ", "First, because the A-D test is a nonparametric test, it is more robust, particularly for traits with abnormal phenotypic distributions and controlled by moderate effects or rare variations[@b24]. ", "For example, two rare genes *BnaC08g09050* and *BnaC08g44370* (MAF = 0.09, 0.08, respectively), which are orthologous to well-known *Arabidopsis SGR2*[@b37] and *5PTASE13*[@b38], were solely detected in the A-D test. ", "Second, population structure has profound effects on the results of GWAS, as reported in a previous study[@b34]. ", "Because the A-D test does not include a correction for population structure, *p-*value overcorrections do not occur when the method is applied to traits that are correlated with population structure[@b39]. ", "Nonetheless, MLM performed better than the A-D test for major QTLs, particularly those with common alleles[@b24], such as *BnaC04g31610* and *BnaC07g15160* (MAF = 0.29, 0.35, respectively). ", "Compared with GLM, MLM is more stringent because it involves familial relationships (kinship) to further reduce *p*-value inflation, which caused false negative results in the present study. ", "For example, the loci harbouring *BnaA07g19520*, *BnaA10g19550* and *BnaA10g26980* failed to reach the significance threshold in MLM but not in GLM, even though the orthologues of these genes in *Arabidopsis*, *TIR1*[@b10], *LAZY1*[@b40] and *SGR9*[@b28], have well-documented roles in branch angle regulation. ", "Because the robust A-D test and GLM may introduce more false positives, it is feasible to combine the A-D test and GLM with MLM to maximize the detection power and take notice of potential false positives.", "\n\nDespite the large number of loci associated with the branch angle trait, few loci were consistently detected in all environments and a considerable number of loci were only detected in one environment ([Table 4](#t4){ref-type=\"table\"}). ", "There are three possible reasons for these results. ", "First, because GLM and the A-D test are permissive models that potentially introduce false positives, certain loci may have represented spurious signals that reflect confounding population structure. ", "Second, environment can influence QTL expression and its magnitude because environment represents the manifestation of complex biotic, abiotic and agronomic factors[@b41]. ", "Indeed, environmental effects are evident in previous QTL mapping analyses[@b41][@b42][@b43]. ", "In the present study, ANOVA analysis revealed that environment did have significant effects on branch angle; therefore, the expression of certain sensitive QTLs could be affected by environment. ", "Third, the GWAS model chosen can also affect the results because different models are proposed based on different statistical assumptions. ", "For example, the locus harbouring one copy of *LAZY1* on C03 was detected in two environments (2012--2013 Nanjing and 2013--2014 Wuhan) by using the A-D test but not by using GLM.", "\n\nBranch angle is a special gravitropic set-point angle (GSA) representing a plant architecture trait that is primarily governed by plant gravitropism; however, the precise mechanisms underlying branch angle maintenance and development remain poorly understood. ", "Interestingly, a recent study proposed a model to address this issue[@b10], showing that an auxin-dependent antigravitropic response acts antagonistically with the gravitropic response to maintain angled growth: the branch angle value is dependent on the magnitude of the antigravitropic response and is mediated via TIR1/AFB-AUX/IAA-ARF-dependent auxin signalling pathway within stem endodermal cells[@b10]. ", "Intriguingly, in the present study, the orthologues of *Arabidopsis* auxin signalling genes, including *TIR1*, *AFB4*, *AXL1*, *RUB1*, *ARF9*, *ARF10* and *IAA13*, were collectively identified as candidate genes ([Supplementary Data S7](#S1){ref-type=\"supplementary-material\"}). ", "Although the precise mechanism underlying the antigravitropic response is not fully understood, this model provides a conceptual framework for understanding the mechanism responsible for the branch angle trait and highlights a new avenue for further research.", "\n\nMethods\n=======\n\nPlant materials\n---------------\n\nA set of 530 diverse rapeseed inbred accessions, including landraces and elite varieties, was collected to construct the association panel, a subset of which was reported in a previous study of flowering time[@b44]. ", "Based on the information obtained for these varieties, plants were assigned to three germplasm types: winter type (41), semi-winter type (435) and spring type (54). ", "The origins of the plants showed that 485 accessions originated from Asia, 32 from Europe, 8 from North America and 5 from Australia ([Supplementary Data S4](#S1){ref-type=\"supplementary-material\"}). ", "Remarkably, China contributed 476 accessions that originated from three rapeseed sub-regions with diverse climates, land fertilities and hydrologies, and these accessions broadly represent the major genetic diversity of the Chinese rapeseed gene pool.", "\n\nExperimental design and trait measurement\n-----------------------------------------\n\nIn 2011/2012 in Wuhan, we measured the branch angles of 30 randomly selected lines at three weeks after the final flowering stage ([Supplementary Data S1](#S1){ref-type=\"supplementary-material\"}). ", "A small section from the base of the stem encompassing each branching node was photographed and analysed using Photoshop to measure the adaxial angle of the branch to the stem. ", "Correlation analysis between the angles of branches at different positions was performed in R^44^.\n\nThe association panel was grown in the 2012/2013 and 2013/2014 growing season using a randomized complete block design with three replications on experimental farms at Changsha (N 28.22°, E 113.00°), Wuhan (N 30.52°, E 114.32°) and Nanjing (N 32.05°, E 118.78°) China. ", "Meteorological data for the three locations are presented in [Supplementary Data S8](#S1){ref-type=\"supplementary-material\"}. ", "Each line was grown in a plot with two rows and 12--15 plants in each row. ", "The phenotypic investigation started approximately three weeks after the final flowering stage. ", "In 2012/2013, we measured the five branches from the top of each plant, and four plants for each accession from two replicates were selected. ", "In 2013/2014, we extended the sample size to 12.", "\n\nCorrelation analysis and analysis of variance (ANOVA) of branch angle for the association panel across different environments was performed in R^44^. Subsequently, an R script based on a linear model was used to obtain the broad-sense heritability and best linear unbiased prediction (BLUP) of the multi-environment phenotypes for each accession[@b45]. ", "The BLUPs and individual environment data were used as the phenotypes for association analysis. ", "Pearson's correlation coefficient between branch angle and multiple agronomic traits, including plant height, branch number, main inflorescence pod number, pod length, seed number per pod, seed weight and seed yield (only data from 2012/2013 and 2013/2014 at Changsha were available for these traits), were calculated in R^44^.\n\nSNP genotyping, filtering and in silico mapping\n-----------------------------------------------\n\nLeaf tissue samples from the entire association panel were obtained from bulk of at least four individuals for each accession at the seedling stage. ", "DNA was extracted using a modified CTAB procedure according to Murray and Thompson[@b46]. ", "The DNA quality was carefully assessed prior to genotyping.", "\n\nSNP genotyping was performed using the Illumina *Brassica* 60K Infinium^®^ SNP array according to the manufacturer's instructions ([http://www.illumina.com/technology/infinium_hd\\_ assay.ilmn](http://www.illumina.com/technology/infinium%20_hd_%20assay.ilmn)). ", "SNP data were clustered and automatically called using Illumina Genome Studio genotyping software. ", "First, accessions with a Call Rate \\< 0.7 were excluded and all SNPs were reclustered. ", "Next, SNPs with Call Freq \\< 0.75, Minor Freq \\< 0.05, AA or BB frequencies \\< 0.03 or GenTrain Scores \\< 0.5 were excluded. ", "The remaining SNPs were manually reassessed, and those that did not show three clearly defined clusters were also excluded. ", "Because heterozygous SNPs cannot be distinguished from hemi-SNPs or false calls, heterozygous calls were treated as missing values.", "\n\nFifty base pair sequences of retained SNPs after filtration were used to perform a BLASTN[@b47] search against the *B.napus* genome database (<http://www.genoscope.cns.fr/brassicanapus/>). ", "Using an *e*-value threshold of *e*^−12^, SNPs corresponding to multiple loci in the genome were excluded, and only the top blast hits were retained for further analysis.", "\n\nPopulation structure, kinship and LD decay\n------------------------------------------\n\nThe filtered SNP dataset for selected accessions with a Call Rate \\> 0.7 was entered into STRUCTURE V2.3.3[@b48]. ", "Five independent runs were performed with a K-value (the putative number of genetic groups) varying from 1 to 10, with the length of the burn-in period and the number of MCMC (Markov Chain Monte Carlo) replications after burn-in both to 100,000 iterations under the admixture model. ", "The most likely K-value was determined using the log probability of data \\[LnP(D)\\], and the *ad hoc* statistic Delta K, which is based on the rate of change of LnP(D) between successive K-values. ", "The cluster membership coefficient matrices of five independent runs from STRUCTURE were integrated to obtain a Q matrix by the CLUMPP software[@b49]. ", "The proportion of phenotypic variation that contributed by population structure was calculated via the lm function in R^44^. Relative kinship coefficients (K) were calculated using the SPADeGi software package[@b50]. ", "All negative values between individuals were set to 0. ", "The linkage disequilibrium measurement parameter r^2^ was used to estimate linkage disequilibrium (LD) of A and C subgenome chromosomes via TASSEL5.0[@b51]. ", "When calculating LD for a specific chromosome, the LD window size was adjusted to the chromosomal SNP number to force the calculation for all marker pairs. ", "Locally paired scatterplot smoothing in R was employed to obtain a graphical representation of LD curves.", "\n\nGenome-wide association study\n-----------------------------\n\nTrait-SNP association analysis was performed using three methods. ", "Both GLM and MLM were implemented in TASSEL 5.0[@b51]. ", "GLM takes into account population structure as a fixed effect. ", "On this basis, MLM incorporates kinship as a random effect to further eliminate the excess of low *p*-values[@b19]. ", "For GLM and MLM, the significance of associations between SNPs and traits was based on the uniform threshold *p* ≤ 5.2 × 10^−5^ (−log~10~(*p)* = 4.3). ", "The A-D test for branch angle was conducted by using the R package ADGWAS 1.0[@b24]. ", "The A-D test is a nonparametric test that includes no correction for population structure. ", "A more stringent threshold was set for the A-D test with *p* ≤ 2.6 × 10^−5^ (−log~10~(*p)* = 5.6).", "\n\nTo better understand the explanatory power of the significant SNPs, we used the SNP genotypes at candidate loci as predictor variables in multiple linear models fitted to the phenotypic variables and subsequently ran a model comparison analysis (stepwise AIC procedure implemented as the R function \"stepAIC\")[@b52] to determine the best fitting model. ", "The adjusted R^2^ of the best fitting multiple regression model was referred to as the phenotypic variation explained by the significant SNPs.", "\n\nCandidate gene mining\n---------------------\n\nTo define regions of interest containing potential candidate genes, local LD decay was calculated within flanking regions up to 12,000 kb on either side of significant SNPs using TASSEL5.0[@b51], and a cut-off value of 0.1 was used for the LD statistic r^2^. Genes within the observed LD decay were annotated using the software Blast2GO v3.3.5 with the default settings[@b53]. ", "In particular, genes with GO terms for gravitropism, amyloplast, and auxin were highlighted. ", "Using the whole genome genes as reference, GO enrichment analysis of all genes within the LD decay ranges was implemented using Fisher's Exact Test in Blast2GO v3.3.5 (false discovery rate \\< 0.05)[@b53]. ", "Next, we performed BLASTX searches against the *Arabidopsis* genome to determine whether candidate SNP-tagged genome regions contain genes orthologous to *Arabidopsis* genes with established roles in shoot gravitropism. ", "Additionally, we exploited the *Arabidopsis* \"Electronic Fluorescent Pictograph\" (eFP) browser[@b54] and microarray data from previously published gravistimulation studies[@b55][@b56][@b57] to further characterize candidate genes. ", "Notably, associated SNPs that are not in or near branch angle-related genes within the LD decay (r^2^ = 0.1) were considered linked to a more distant gene, and the closest one of these genes was considered the most likely candidate.", "\n\nAdditional Information\n======================\n\n**How to cite this article**: Sun, C. *et al.* ", "Genome-Wide Association Study Dissecting the Genetic Architecture Underlying the Branch Angle Trait in Rapeseed (*Brassica napus* L.). *", "Sci. ", "Rep.* **6**, 33673; doi: 10.1038/srep33673 (2016).", "\n\nSupplementary Material {#S1}\n======================\n\n###### Supplementary Information\n\n###### Supplementary Dataset S1\n\n###### Supplementary Dataset S2\n\n###### Supplementary Dataset S3\n\n###### Supplementary Dataset S4\n\n###### Supplementary Dataset S5\n\n###### Supplementary Dataset S6\n\n###### Supplementary Dataset S7\n\n###### Supplementary Dataset S8\n\n###### Supplementary Dataset S9\n\n###### Supplementary Dataset S10\n\nWe appreciate the instructive suggestions from professor Yuanming Zhang and Jianbing Yan. ", "This work was supported by the National High Technology Research and Development Program of China (Grant No. ", "2012AA101107), the National Key Research and Development Program of China (2016YFD0101300) and 948 Program of Ministry of Agriculture of China (2011-G23).", "\n\n**Author Contributions** T.F. and B.Y. designed the experiments. ", "J.W., J.T. and J.S. advised on the experimental design. ", "X.W. and C.S. performed the genotyping experiment. ", "C.S., B.W., K.L., Z.L., S.L. and L.Y. performed the phenotyping measurements. ", "C.G., J.F., Z.Z. and S.C. contributed to the association panel field management. ", "C.S. and K.H. performed the data analysis. ", "C.S. wrote the manuscript.", "\n\n{#f1}\n\n{ref-type=\"supplementary-material\"}.](srep33673-f2){#f2}\n\n###### Correlations between the angles of different branches.", "\n\n Trait^a^ ALLBA 1-5BA 1-4BA 1-3BA 1-2BA 1BA 2BA 3BA 4BA\n ---------- ------------ ------------ ------------ ------------ ------------ ------------ ------------ ------------ ------------\n 1-5BA 0.93\\*\\*\\*                \n 1-4BA 0.92\\*\\*\\* 0.99\\*\\*\\*              \n 1-3BA 0.86\\*\\*\\* 0.95\\*\\*\\* 0.98\\*\\*\\*            \n 1-2BA 0.79\\*\\*\\* 0.90\\*\\*\\* 0.94\\*\\*\\* 0.97\\*\\*\\*          \n 1BA 0.71\\*\\*\\* 0.81\\*\\*\\* 0.84\\*\\*\\* 0.86\\*\\*\\* 0.92\\*\\*\\*        \n 2BA 0.75\\*\\*\\* 0.85\\*\\*\\* 0.88\\*\\*\\* 0.92\\*\\*\\* 0.92\\*\\*\\* 0.69\\*\\*\\*      \n 3BA 0.81\\*\\*\\* 0.85\\*\\*\\* 0.86\\*\\*\\* 0.85\\*\\*\\* 0.69\\*\\*\\* 0.54\\*\\* 0.72\\*\\*\\*    \n 4BA 0.90\\*\\*\\* 0.89\\*\\*\\* 0.86\\*\\*\\* 0.74\\*\\*\\* 0.68\\*\\*\\* 0.64\\*\\*\\* 0.61\\*\\*\\* 0.71\\*\\*\\*  \n 5BA 0.78\\*\\*\\* 0.83\\*\\*\\* 0.72\\*\\*\\* 0.64\\*\\*\\* 0.57\\*\\*\\* 0.51\\*\\* 0.53\\*\\*\\* 0.65\\*\\*\\* 0.79\\*\\*\\*\n\n^a^ALLBA: average angle of all branches; 1-5BA: average angle of the five branches from the top; 1-4BA: average angle of the four branches from the top; 1-3BA: average angle of the three branches from the top; 1-2BA: average angle of the two branches from the top; 1BA: angle of the first branch from the top; 2BA: angle of the second branch from the top; 3BA: angle of the third branch from the top; 4BA: angle of the fourth branch from the top; 5BA: angle of the fifth branch from the top. ", "The significance level: \\*p ≤ 0.05; \\*\\*p ≤ 0.01; \\*\\*\\*p ≤ 0.001.", "\n\n###### Phenotypic variations in branch angle for the rapeseed panel in four environments.", "\n\n Environment Min ± SD (°) Max ± SD (°) Mean ± SD (°) CV (%)\n -------------------- -------------- -------------- --------------- --------\n 2012/2013 Changsha 28.4 ± 2.6 71.7 ± 4.8 43.2 ± 6.3 14.5\n 2012/2013 Nanjing 21.7 ± 1.9 59.6 ± 3.8 40.7 ± 6.6 16.2\n 2013/2014 Changsha 26.0 ± 3.2 57.7 ± 6.0 40.3 ± 6.3 15.7\n 2013/2014 Wuhan 27.2 ± 3.3 56.8 ± 3.1 41.6 ± 6.3 15.1\n\n###### Correlations between branch angle and other traits in the 2012/2013 Changsha samples.", "\n\n Trait BA PH BN MIPN PL SNPP SW\n ------- ------------ ------------ ------------- ------------ ------------ ------------ ------------\n PH 0.25\\*\\*\\*            \n BN 0.17\\*\\*\\* 0.26\\*\\*\\*          \n MIPN 0.11\\*\\*\\* 0.29\\*\\*\\* 0.02        \n PL 0.11\\*\\*\\* 0.19\\*\\*\\* 0.01 −0.03      \n SNPP 0.13\\*\\*\\* 0.23\\*\\*\\* 0.04 −0.02 0.60\\*\\*\\*    \n SW 0.04 0.00 −0.14\\*\\*\\* 0.00 0.26\\*\\*\\* 0.13\\*\\*\\*  \n SY 0.10\\*\\* 0.37\\*\\*\\* 0.27\\*\\*\\* 0.29\\*\\*\\* 0.29\\*\\*\\* 0.29\\*\\*\\* 0.17\\*\\*\\*\n\nBA: branch angle; PH: plant height; BN: branch number; MIPN: main inflorescence pod number; PL: pod length; SNPP: seed number per pod; SW: seed weight; SY: seed yield. ", "The significance level: \\**p* ≤ 0.05; \\*\\**p* ≤ 0.01; \\*\\*\\**p* ≤ 0.001.", "\n\n###### SNPs significantly associated with branch angle.", "\n\n QTLs SNPs Chr Position MAF[a](#t4-fn1){ref-type=\"fn\"} Allele −log10(*p*) (MLM) Environment (MLM)[b](#t4-fn2){ref-type=\"fn\"} R^2^ (MLM) −log10(*p*) (GLM) Environment (GLM)[b](#t4-fn2){ref-type=\"fn\"} R^2^ (GLM) −log10(*p*) (A-D test) Environment (A-D test)[b](#t4-fn2){ref-type=\"fn\"}\n ------ ------------------------------- ----- ---------- -------------------------------- --------- ------------------- ---------------------------------------------- ------------ ------------------- ---------------------------------------------- ------------ ------------------------ ---------------------------------------------------\n 1 Bn-A01-p7430311 A01 6794653 0.32 \\[A/G\\]       5.1--5.7 BLUP,CS14 3.9--5 6.1--6.4 BLUP,CS14\n 2 **Bn-A01-p7974551** A01 7156865 0.42 \\[T/C\\]       4.3--4.4 CS14,WH14 3.1--3.7 6.0--7.1 BLUP,NJ13,WH14\n 3 **Bn-A02-p27245861** A02 24567443 0.30 \\[A/G\\]             5.7--7 BLUP,NJ13,WH14\n 4 Bn-A03-p4342338 A03 3874153 0.32 \\[T/C\\] 5.5 BLUP 4.9 5.0--6.2 BLUP,NJ13 3.7--5.1    \n 5 Bn-A03-p5814447 A03 5245728 0.41 \\[A/G\\]       4.3 BLUP 3.3    \n 6 **Bn-A03-p6228570** A03 5594660 0.27 \\[T/C\\] 4.7--6.3 BLUP,CS13 3.6--3.9 4.4--5.5 BLUP,CS13,NJ13 2.9--3.3 5.6--5.7 BLUP,NJ13\n 7 Bn-A03-p7178650 A03 6451720 0.16 \\[T/C\\]       4.7--5.2 BLUP,NJ13 3.4--4.0    \n 8 **Bn-A03-p7572128** A03 6882418 0.10 \\[T/G\\] 4.3 BLUP 3.2 5.5--6.3 BLUP,NJ13,WH14 3.5--4.0    \n 9 **Bn-A03-p8033095** A03 7321907 0.27 \\[T/C\\]       5.0--5.1 BLUP,NJ13 3.7--3.9 6.2--6.8 BLUP,NJ13,WH14\n 10 **Bn-A03-p8554739** A03 7848675 0.33 \\[T/C\\]       4.5--6.0 BLUP,CS13,WH14 3.6--4.6 6.5--7.1 BLUP,WH14\n 11 Bn-A03-p15347967 A03 14385059 0.30 \\[A/G\\]             6.2 BLUP\n 12 Bn-A03-p25868537 A03 24234777 0.27 \\[A/G\\]       4.5--5.7 BLUP,WH14 3.4--4.3    \n 13 **Bn-A03-p28982546** A03 27392934 0.24 \\[T/C\\]       5.4--5.7 BLUP,CS13,NJ13 4.0--4.5    \n 14 **Bn-A04-p3631563** A04 3299951 0.13 \\[A/G\\] 4.8--6.7 BLUP,NJ13,CS13 4.1--6.0 4.5--8.6 BLUP,CS13,NJ13,CS14 3.5--6.6    \n 15 Bn-A04-p4410144 A04 4532791 0.27 \\[T/C\\] 4.7--5.5 BLUP,NJ13 4.2--4.9 6.0--6.4 BLUP,NJ13 4.6--5.2 5.9 NJ13\n 16 **Bn-A04-p2411039** A04 5850169 0.14 \\[A/G\\] 4.6--4.8 BLUP,NJ13,CS13 3.8--4.3 5.5--6.3 BLUP,CS13,NJ13 4.3--4.9    \n 17 **Bn-A04-p6296526** A04 7519507 0.23 \\[A/C\\] 4.9 BLUP 3.7 4.8--4.8 CS13,NJ13 3.2--3.2    \n 18 Bn-A04-p6929056 A04 8211241 0.35 \\[T/C\\]       4.4 BLUP 3.5    \n 19 Bn-A05-p6415983 A05 5963980 0.07 \\[A/G\\]       4.6 BLUP 3.0    \n 20 Bn-A05-p21065087 A05 19223021 0.43 \\[A/G\\]       4.6 BLUP 3.7    \n 21 Bn-A06-p5114770 A06 4927748 0.27 \\[T/C\\]       4.4 BLUP 3.4    \n 22 Bn-A10-p11839950 A07 2293313 0.27 \\[T/C\\]       4.5--4.5 BLUP,WH14 3.5--3.6    \n 23 **Bn-A07-p4191541** A07 6111458 0.47 \\[T/C\\]       5.7--7.6 BLUP,NJ13,WH14 4.7--6.4 6.7--7.7 BLUP,NJ13,WH14\n 24 **Bn-A07-p5412930** A07 7273126 0.47 \\[A/G\\]       4.6--5.1 BLUP,CS13,WH14 3.4--4.1 5.8--6.6 BLUP,CS13,WH14\n 25 Bn-A07-p9921856 A07 11205489 0.24 \\[T/G\\]       4.4--5.6 BLUP,NJ13 2.7--3.8    \n 26 Bn-A07-p10869578 A07 12103546 0.27 \\[T/C\\]       4.5--4.7 BLUP,WH14 3.3--3.6    \n 27 **Bn-A07-p13172047** A07 15255974 0.22 \\[A/G\\] 5.1 CS13 4.5 4.9--5.7 BLUP,CS13,WH14 3.6--4.5 6.1 CS13\n 28 Bn-A07-p13662635 A07 15655194 0.17 \\[T/C\\]       5.4--5.5 BLUP,WH14 3.9--3.9    \n 29 Bn-A07-p15007983 A07 16890653 0.32 \\[T/G\\]             5.6 BLUP\n 30 Bn-A07-p15505090 A07 17408302 0.46 \\[T/G\\]       4.3 BLUP 2.6    \n 31 Bn-A07-p18021746 A07 19874380 0.33 \\[T/C\\]       4.7--5.1 BLUP,CS14 3.7--4.5    \n 32 Bn-A08-p13638847 A08 11390087 0.29 \\[T/G\\]       4.3--6.7 BLUP,CS14 2.6--4.7 5.5 BLUP\n 33 Bn-A09-p2208929 A09 1382771 0.20 \\[A/G\\]       4.4--5.2 BLUP,CS14 2.9--3.9    \n 34 **Bn-A09-p36803825** A09 33753723 0.09 \\[T/C\\] 4.9--5.4 BLUP,CS14,CS13 3.9--4.3 4.5--7.7 BLUP,CS13,NJ13, CS14,WH14 3.2--5.1    \n 35 Bn-A10-p7394578 A10 9067281 0.48 \\[A/G\\]       4.3--5.2 BLUP,WH14 3.3--4.1    \n 36 Bn-A10-p10671726 A10 12042143 0.15 \\[T/C\\]       4.4--6.6 BLUP,CS13 3.2--5.3    \n 37 Bn-A10-p13818569 A10 13855272 0.40 \\[T/C\\]       4.6--4.6 BLUP,CS13 4.0 5.6--6.3 BLUP,CS13\n 38 Bn-A10-p17414621 A10 17217158 0.08 \\[T/C\\] 4.4 NJ13 3.6 4.8--6.3 BLUP,NJ13 3.3--4.6    \n 39 Bn-scaff_20461_1-p322463 C02 9345306 0.11 \\[A/C\\]       5.6 BLUP 3.5    \n 40 Bn-scaff_16614_1-p1480092 C03 660277 0.08 \\[T/G\\]       4.5--5.1 BLUP,WH14 2.7--3.2    \n 41 **Bn-scaff_18936_1-p472353** C03 3058478 0.32 \\[A/G\\]       4.6 BLUP 3.3 6.2--8.7 BLUP,NJ13,WH14\n 42 Bn-scaff_18322_1-p2487448 C03 6744282 0.40 \\[A/C\\]             6.2--6.6 BLUP,WH14\n 43 Bn-scaff_15794_3-p533873 C03 55055879 0.34 \\[T/C\\]       4.4 BLUP 3.2    \n 44 Bn-scaff_16876_1-p1162532 C04 33772508 0.29 \\[A/C\\] 4.4--5.8 BLUP,CS13 3.3--4.5 6.3 CS13 4.2    \n 45 **Bn-scaff_15798_1-p281492** C04 36910519 0.15 \\[T/C\\] 5.0--5.0 BLUP,CS14 4.3--4.3 5.7--7.5 BLUP,CS14,WH14 4.4--5.3    \n 46 **Bn-scaff_16062_1-p345501** C05 15699504 0.40 \\[A/G\\] 4.9 CS13 4.5 4.4--7.4 BLUP,CS13,CS14,WH14 3.2--6.2 6.1--7.3 BLUP,CS13\n 47 Bn-scaff_18206_1-p453711 C06 18723815 0.45 \\[T/C\\]             6.0--6.3 BLUP,WH14\n 48 Bn-scaff_19106_1-p76331 C07 18982139 0.26 \\[A/G\\]             6.3--9.9 BLUP,NJ13\n 49 Bn-scaff_18501_1-p114150 C07 21145676 0.35 \\[A/G\\] 4.6--5.7 BLUP,NJ13 3.9--5.0 4.6--5.3 BLUP,NJ13 3.4--4.2    \n 50 Bn-scaff_16468_1-p450133 C08 13342433 0.09 \\[T/G\\]             5.6 BLUP\n 51 **Bn-scaff_16200_1-p208618** C08 27277109 0.19 \\[T/C\\]       4.3--5.2 BLUP,CS13,NJ13,CS14 3.4--4.2 5.6 NJ13\n 52 **Bn-scaff_16197_1-p2492352** C08 31718611 0.47 \\[T/C\\] 4.5 BLUP 3.9 4.3--5.8 BLUP,CS13,CS14 3.2--4.7    \n 53 **Bn-scaff_16197_1-p1333425** C08 32784282 0.28 \\[A/T\\]       4.6--5.3 BLUP,NJ13,WH14 3.4--3.9 6.1 WH14\n 54 Bn-scaff_16389_1-p436578 C08 37667324 0.08 \\[A/G\\]             5.9--6.1 BLUP,WH14\n 55 **Bn-scaff_17526_1-p1470085** C09 1151339 0.35 \\[T/G\\] 5.0 WH14 3.8 5.7--8.0 BLUP,CS14,WH14 3.9--5.2    \n 56 Bn-scaff_16362_1-p621813 C09 43501182 0.20 \\[A/G\\]       5.4 WH14 3.8 5.6--6.0 BLUP,WH14\n\n^a^MAF: minor allele frequency.", "\n\n^b^NJ13: 2012/2013 Nanjing, CS13: 2012/2013 Changsha, CS14: 2013/2014 Changsha, WH14: 2013/2014 Wuhan. ", "SNPs indicated in bold were consistently detected in at least two environments in the present study.", "\n" ]

{ "pile_set_name": "PubMed Central" }

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[ "Support for families and children with special needs.", "\nOne home care agency's staff identified community needs and developed three pediatric programs to address those needs. ", "The programs include case management, a respite program, and parent education to prevent child abuse or neglect. ", "All programs strengthen the families and thus the community this agency serves and are thus good examples of an agency's use of all resources at hand." ]

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[ "from .visualizer import visualize, visualize_parser, visualize_ner\nfrom .visualizer import visualize_textcat, visualize_similarity, visualize_tokens\nfrom .util import load_model, process_text\n" ]

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[ "South Georgia Medical Center\n\nSouth Georgia Medical Center is one of two hospital providers in Valdosta, Georgia and surrounding Lowndes County, Georgia. ", "The facility opened in 1955 on Alternate Georgia State Route 7 (N Patterson St) north of downtown Valdosta. ", "The hospital has 288 inpatient beds and is locally operated.", "\n\nReferences\n\nExternal links\n South Georgia Medical Center\n\nCategory:Hospital buildings completed in 1955\nCategory:Hospitals in Georgia (U.S. state)\nCategory:Buildings and structures in Lowndes County, Georgia\nCategory:1955 establishments in Georgia (U.S. state)" ]

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[ "Q:\n\nHow to add GridViewColumn with image cells properly in WPF app\n\nIf I add just string value columns - all working well:\ngridView.", "Columns.", "Add(new GridViewColumn\n{\n Header = \"ExecFileName\",\n DisplayMemberBinding = new Binding(\"ExecFileName\")\n});\n\nbut how I can add column with BitmapImage or ImageSource value in cellls of this column for example ?", "\nWhatever I did - I always see only path to the image file - how I can show image itself ?", "\nP.S.: I am creating GridView from code, in xaml I have only:\n<ListView x:Name=\"ResultListView\" \n BorderThickness=\"2,0,2,0\" \n BorderBrush=\"Gray\" \n Height=\"Auto\" \n Width=\"Auto\" \n Margin=\"0,0,0,10\" \n RenderTransformOrigin=\"0.502,2.299\" \n AutomationProperties.", "IsColumnHeader=\"True\" \n Loaded=\"ResultListView_Loaded\" \n MouseDoubleClick=\"ResultListView_MouseDoubleClick\" >\n</ListView>\n\nA:\n\nSince you are creating the GridView in code-behind, you also need to create the Binding to the ImageSource/BitmapSource in the code-behind.", "\nHere is an example that produces this list view:\n\nThe MainWindow.xaml file is:\n<Window x:Class=\"WpfApplication6.MainWindow\"\n xmlns=\"http://schemas.microsoft.com/winfx/2006/xaml/presentation\"\n xmlns:x=\"http://schemas.microsoft.com/winfx/2006/xaml\"\n xmlns:d=\"http://schemas.microsoft.com/expression/blend/2008\"\n xmlns:mc=\"http://schemas.openxmlformats.org/markup-compatibility/2006\"\n xmlns:local=\"clr-namespace:WpfApplication6\"\n mc:Ignorable=\"d\"\n Title=\"MainWindow\" Height=\"150\" Width=\"250\"\n d:DataContext=\"{d:DesignData d:Type=local:MainWindow}\">\n <Grid>\n <ListView x:Name=\"ResultListView\" \n ItemsSource=\"{Binding Items}\"\n BorderThickness=\"2,0,2,0\" \n BorderBrush=\"Gray\" \n Height=\"Auto\" \n Width=\"Auto\" \n Margin=\"0,0,0,10\" \n RenderTransformOrigin=\"0.502,2.299\" \n AutomationProperties.", "IsColumnHeader=\"True\">\n </ListView>\n </Grid>\n</Window>\n\nThe code-behind is this (MainWindow.xaml.cs):\nusing System;\nusing System.", "Collections.", "ObjectModel;\nusing System.", "Windows;\nusing System.", "Windows.", "Controls;\nusing System.", "Windows.", "Data;\nusing System.", "Windows.", "Media.", "Imaging;\n\nnamespace WpfApplication6\n{\n /// <summary>\n /// Interaction logic for MainWindow.xaml\n /// </summary>\n public partial class MainWindow : Window\n {\n public ObservableCollection<Item> Items { get; } = new ObservableCollection<Item>(new[]\n {\n new Item { ExecFileName = @\"C:\\Temp\\icon1.png\" },\n new Item { ExecFileName = @\"C:\\Temp\\icon2.png\" }\n });\n\n public MainWindow()\n {\n InitializeComponent();\n DataContext = this;\n\n FrameworkElementFactory factory = new FrameworkElementFactory(typeof(Image));\n factory.", "SetBinding(Image.", "SourceProperty, new Binding(\"ImageSource\"));\n\n GridView gridView = new GridView();\n gridView.", "Columns.", "Add(new GridViewColumn\n {\n Header = \"FileName\",\n DisplayMemberBinding = new Binding(\"ExecFileName\")\n });\n gridView.", "Columns.", "Add(new GridViewColumn\n {\n Header = \"Image\",\n CellTemplate = new DataTemplate() { VisualTree = factory }\n });\n ResultListView.", "View = gridView;\n }\n }\n\n public class Item\n {\n public string ExecFileName { get; set; }\n\n public BitmapImage ImageSource\n {\n get\n {\n return new BitmapImage(\n new Uri(ExecFileName, UriKind.", "RelativeOrAbsolute));\n }\n }\n }\n}\n\n" ]

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[ "Protein expression of melanocyte growth factors (bFGF, SCF) and their receptors (FGFR-1, c-kit) in nevi and melanoma.", "\nBasic fibroblast growth factor (bFGF) and stem cell factor (SCF) are essential growth factors for melanocytes which carry the receptors FGFR-1 for bFGF and c-kit for SCF. ", "Because both factors may be involved in melanoma development, the expression of bFGF/FGFR-1 and SCF/c-kit was investigated in melanocytic tumors of different progression stages. ", "Fifty primary melanomas and 44 melanocytic nevi were analyzed for the expression of SCF, c-kit, bFGF, and FGFR-1 by immunohistochemistry. ", "In melanoma, SCF and c-kit were expressed in 76 and 84%, respectively, and coexpressed in 66%. ", "bFGF and FGFR-1 were expressed in 45 and 86%, respectively, and coexpressed in 46%. ", "In melanocytic nevi, SCF was expressed in 23% and c-kit in 70% while coexpression was more common in dysplastic (39%) than non-dysplastic subtypes (8%). ", "bFGF and FGFR-1 were expressed in 55 and 67%, respectively, while coexpression was found in 47% but varied considerably between different histological subtypes. ", "SCF and c-kit were frequently expressed by melanomas and dysplastic nevi suggesting an autocrine growth mechanism as described for bFGF. ", "In both nevi and melanoma, c-kit was almost exclusively found in the epidermis while bFGF was more common in the dermis. ", "Thus the growth factor/receptor expression seems to depend on the cutaneous localization of the melanocytic tumors." ]

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[ "Betty White on stage with Mary Tyler Moore\n\nThe presence of veteran television and film actress Betty White made Emmy Award, 2008, even more special. ", "Seven time Emmy Award winning actress Mary Tyler Moore took the stage and introduced Betty White, who has been on television for 60 years.", "\n\nThe duo received standing ovation from the audience. ", "Then they presented the award for Outstanding Comedy Series. ", "The award went to '30 Rocks', the television series created by Tina Fey." ]

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[ "\n103 F.Supp.2d 1259 (2000)\nUNITED STATES of America, Plaintiff,\nv.\nPhilip PETERSON, Thomas Graham, Jim Kelly, Lisa Sanchez Graham, Martha Peterson, Jacki Kelly, Richard Doty, Logan Farr, Ted Folk, Jerry Jennings, Dexter Lott, Dan Murphy, Deryn Riggs, Manuel Sanchez, and Ron Zorich Defendants.", "\nNo. ", "CRIM. ", "A. 98-CR-402.", "\nUnited States District Court, D. Colorado.", "\nJuly 10, 2000.", "\n*1260 John Henry Schlie, John Henry Schlie & Barry A. Schwartz, PC, Denver, CO, for Philip Peterson.", "\nRichard N. Stuckey, Richard N. Stuckey, P.C., Denver, CO, for Thomas Graham.", "\nStephen M. Wheeler, Stephen Wheeler, Atty at Law, Evergreen, Peter Schild, Peter Schild Law Office, Boulder, CO, for Jim Kelly.", "\nJohn Andrew Chanin, Isaacson, Rosenbaum, Woods & Levy, P.C., Denver, CO, for Lisa Sanchez Graham.", "\nPhilip W. Ogden, Philip Ogden, Atty at Law, Colorado Springs, CO, for Martha Peterson.", "\nMitchell Baker, Mitchell Baker, Atty at Law, Denver, for Jacki Kelly (6), defendants.", "\nEugene Scott Baroway, Baroway, Porter & Thomas, Englewood, CO, for Richard Doty.", "\n*1261 David Barry Savitz, David B. Savitz, Atty at Law, Denver, CO, for Logan Farr.", "\nKirkland Leonard Brush, Fort Collins, CO, for Jerry Jennings.", "\nAnn Phillips Kaufman, Ann P. Kaufman, P.C., Colorado Springs, CO, for Dexter Lott.", "\nThomas G. Martin, Thomas G. Martin, Attorney, PC, Colorado Springs, CO, for Dan Murphy.", "\nCraig B. Shaffer, Moye, Giles, O'Keefe, Vermeire & Gorrell, Terry Jo Epstein, Dufford & Brown, P.C., Denver, CO, for Deryn Riggs.", "\nElisa Julie Moran, Elisa J. Moran, Atty at Law, Denver, CO, for Manuel Sanchez.", "\nDaniel N. Recht, Daniel N. Recht, PC, Denver, for Ron Zorich (15), defendants.", "\nJoseph Mackey, III, Assistant U.S. Atty's Offfice Criminal Division, Denver, CO, for U.S.\n\nFINDINGS OF FACT, CONCLUSIONS OF LAW AND ORDER\nBABCOCK, Chief Judge.", "\nDefendant Thomas Graham (\"Graham\") moves to suppress business records, items, and documents seized pursuit to search warrant. ", "Defendants Philip Peterson (\"Peterson\"), James Kelly (\"Kelly\"), and Logan Farr (\"Farr\") joined the motion. ", "Oral argument and an evidentiary hearing was held on June 27, 2000. ", "Based on the motions, responses, counsels' arguments, and evidence presented, I deny the motion.", "\n\nI. Background\nOn October 31, 1995 a search and seizure warrant was issued for the offices of American Exchange Group, Inc. (\"AEG\"). ", "The warrant was executed by Federal Bureau of Investigation agents at AEG's Longmont, Colorado office on November 1, 1995. ", "On October 22, 1998 an indictment was returned charging fifteen AEG employees with various counts of mail fraud, wire fraud, and aiding and abetting in violation of 18 U.S.C. §§ 1341, 1343 & 2. ", "The indictment alleges that AEG solicited owners of time share vacation properties throughout the United States via mail and telephone. ", "Owners were allegedly told by AEG employees that in exchange for a certain sum of money, AEG would hold meetings for prospective buyers and sell the properties in a short amount of time. ", "Owners allegedly sent money via United States mail or Federal Express to AEG, in the form of checks or cash. ", "Despite their promises, AEG did not sell these properties. ", "Peterson, Graham, and Kelly were charged as \"principals\" in the scheme to defraud, while the remainder of the defendants were charged as \"telemarketers\" in the scheme.", "\nDefendants argue that all items seized pursuant to the search warrant should be suppressed because: (1) the warrant lacked probable cause; (2) the warrant violates the particularity requirements as to matter to be searched for and seized; and (3) the warrant and search were overbroad. ", "The government argues otherwise, and argues that the FBI agents relied on a facially valid warrant, curing any deficiency under Leon.", "\n\nII. ", "Findings of Fact\nAll parties to the motion with the exception of Mr. Farr took part in an evidentiary hearing on June 27, 2000. ", "Therefore, Mr. Farr is not bound by this order. ", "Based on that hearing, I enter the following findings of fact.", "\nIn July of 1994 FBI Special Agent Mahon (\"SA Mahon\") received a tip from Margaret Chancellor. ", "Ms. Chanchelor worked at AEG as a telemarketer. ", "She informed SA Mahon that she believed false statements were being made to potential AEG customers regarding the ability of AEG to find buyers for properties, the existence of computers for checking properties, and the existence of a buying division at AEG. ", "She informed SA Mahon that she believed these statements were in direct contravention of the AEG employee manual, which forbade telemarketers from telling customers falsities.", "\n*1262 In approximately August of 1994, SA Mahon was contacted by Paul De John. ", "Mr. De John was a telemarketer at AEG. ", "He, too, reported that he believed false statements were being made to AEG customers regarding the existence of buyers for the properties, that customers were told \"we're checking the computer now\" for buyers when in fact there were neither buyers nor computers, and representations to customers that their properties were \"`A' rated\" when there was no rating system. ", "Mr. De John gave SA Mahon a sales script and a training tape recorded at a July 1994 sales meeting run by Mr. Peterson. ", "The statements on the tape caused SA Mahon to conclude that Mr. Peterson was instructing telemarketers to make false statements to customers.", "\nSA Mahon also interviewed Kay Nichols, a bookkeeper at AEG, and Ginnie Gannon, a receptionist/ secretary at AEG. ", "They corroborated the information from Ms. Chancellor and Mr. De John. ", "He then contacted the Boulder County District Attorney's Office and the Colorado Attorney General's Office. ", "Both had received voluminous complaints regarding AEG. ", "SA Mahon then had FBI agents interview possible victims. ", "He had 11 or 12 of these victims consensually record telephone conversations with 17 AEG employees between February of 1995 and September of 1995. ", "These calls revealed promises by AEG that properties would be sold quickly, buyers existed and wanted properties similar to the seller's property, properties would be sold through face-to-face meetings, the seller's property was `A' rated, and it was impossible that the property would not sell. ", "None of these seller's properties were sold.", "\nSellers were also told that PassKey Holidays, Inc., (\"PKH\") was responsible for recruiting potential buyers and selling the properties listed with AEG through face-to-face meetings. ", "In October of 1995 SA Mahon had 4 undercover FBI agents attend a promotional talk at PKH's main office at the Denver Tech Center. ", "At these PKH promotions, agents learned that PKH was selling memberships in a package travel company, not time share properties. ", "Although agents represented that they were interested in buying time shares, PKH employees told agents that PKH didn't sell time shares and suggested that they contact its \"sister company,\" AEG. ", "An FBI agent contacted AEG posing as a potential buyer. ", "She was not referred to PKH, but was told she could work through Ms. Peterson at AEG.", "\nSA Mahon determined that AEG was listed with the Colorado Attorney General's Office as Eagle Rise Marketing (\"ERM\") d/b/a American Enterprise Group. ", "The front door of AEG listed both AEG and PKH. ", "AEG was listed as the subscriber of PKH's telephone number. ", "SA Mahon also discovered that AEG was advertising in national newspapers.", "\nBased on this information SA Mahon determined that AEG customers were relying on AEG promises that AEG had current buyers available and that buyers were recruited through face-to-face sales meetings. ", "He determined these statements were false. ", "SA Mahon then prepared a 39 page affidavit for a search warrant (\"Affidavit\"), and Application for the warrant (\"Application\"), as well as the warrant itself. ", "He contacted SA Roberts of the Telemarketing Task Force at the San Diego FBI Office. ", "SA Roberts confirmed that the items specified in the search warrant were those likely to be found in a boiler room telemarketing operation. ", "SA Mahon also checked with Ms. Nichols, who reported seeing all of the items listed on the warrant at the AEG offices, with the exception of complaint letters.", "\nSA Mahon presented the Affidavit, Application, and warrant to Assistant United States Attorney Mackey. ", "These items were then presented to United States Magistrate Judge Borchers in the District Court for the District of Colorado. ", "Attached to the Application and incorporated in it were: (1) Attachment A, a description of the location of the AEG offices in Longmont, Colorado; (2) Attachment B, a list of *1263 items to be seized, labeled (a) through (t), with item (r) limiting the search to items pertaining to the time period between August 1994 and \"the present\" (October 31, 1995); and (3) Attachment C, a description of the alleged fraud and a list of the United States Code sections alleged to be violated. ", "The Affidavit did not discuss the ability or efforts of AEG to find buyers, an audio training tape, or the October 1995 visit by agents to PKH. ", "The Affidavit did list in great detail the interviews with victims and the taped telephone conversations with AEG employees.", "\nOn October 31, 1995 Magistrate Judge Borchers made a finding of probable cause and signed the warrant. ", "Attachments A and B were physically attached to the warrant and incorporated by reference in it. ", "Attachment C was neither attached nor incorporated. ", "Nowhere in the warrant was the applicable statute listed or described. ", "SA Mahon testified that the warrant went through FBI and U.S. Attorney's Office review before going to the Magistrate Judge and that the failure to incorporate Attachment C or the Affidavit into the warrant was an oversight. ", "The warrant was signed and then ordered sealed by Magistrate Judge Borchers.", "\nOn October 31, 1995 a meeting was held with all FBI agents scheduled to participate in the search. ", "They were informed of the logistics of the operation and were required to read copies of the Affidavit, Attachments A through C, and the warrant itself. ", "All were given an opportunity to ask questions about them.", "\nOn the morning of November 1, 1995 the warrant was executed at the Longmont, Colorado AEG offices. ", "The offices were secured, a floor plan was sketched, and offices and their contents were labeled on the floor plan by letter. ", "The offices were then searched. ", "Employees were detained and asked to provide their names, social security numbers, and dates of birth. ", "Each employee was checked for outstanding warrants and given a chance to talk with FBI agents. ", "Some accepted, some declined, and one was arrested on an outstanding warrant. ", "At some point during the search AEG's lawyer arrived. ", "He was given access to the site and the employees. ", "He informed employees that they were not required to speak with the FBI.", "\nDuring the course of the search SA Mahon supervised and was available for questions, as was his second in command, SA Helena Dugo (formerly SA Krajewski). ", "SA Dugo had copies of the Affidavit, all Attachments, and the warrant on site. ", "The majority of agents asked questions at some point during the almost eight hour search regarding the scope of the warrant. ", "All questions were answered with reference to those documents. ", "At some point during the search additional agents were brought in to assist. ", "They, too, were required to read the Affidavit, all three Attachments, and the warrant. ", "AUSA Mackey was contacted at least once by telephone to assist in determining the parameters of the warrant.", "\nItems taken pursuant to the warrant included the file server and one backup tape of computer data, items with PKH information on them if they also appeared connected with AEG, and files with customer information that fell within the applicable dates regardless of whether the entire file fell into those dates. ", "Computer systems were seized by SA Jeffrey Diehl and SA Casson, with consultation with the AEG systems analyst. ", "They, too, reviewed the Affidavit, Application, Attachments, and warrant. ", "They made recommendations regarding what computer items should be seized. ", "Those recommendations were either accepted, rejected, or modified by SA Mahon based on the parameters of the warrant. ", "AEG's computer and data systems were left largely intact by the search. ", "Representative samples were taken of offer letters, solicitation postcards, and returned solicitation postcards. ", "Items not taken included the majority of the computers, the majority of the phone system, one complete backup tape of the file server, personal employee records including Mr. Peterson's bank records, *1264 and employee tax refund checks. ", "Copies of the later were made.", "\nDuring the search agents contacted Larry Hubbard, whose offices were in the AEG office. ", "He represented to agents that he was with Colorado Data Systems, was an independent contractor of AEG, and was not subject to the search. ", "Mr. Hubbard's lawyer was present for this conversation. ", "Agents agreed that the Colorado Data Systems office was not subject to the warrant. ", "Hubbard then consented to a search of his office and gave agents samples of information from a marketing program he was working on for AEG.", "\nAt the conclusion of the search, photographs were taken of the searched areas, all ninety inventory sheets were checked by both SAs Mahon and Dugo, and copies of those sheets were given to Lisa Sanchez Graham, a principal of AEG. ", "Because the warrant and attachments were sealed by order of the Magistrate Judge, copies were not left on site. ", "The following day AEG bank accounts were seized pursuant to a grand jury order. ", "However, AEG opened for business on November 2, 1995.", "\n\nIII. ", "Conclusions of Law\nDefendants argue that: (1) the warrant lacked information regarding AEG's buying efforts and with that information there would have been no probable cause; (2) the warrant and supporting documentation violate the particularity requirement as Attachment C was absent from the warrant itself; and (3) the warrant and search were overbroad.", "\n\nA. Probable Cause\nTo be valid, a search warrant must be based on probable cause. ", "Probable cause exists when there are reasonable grounds to believe that the items sought to be seized are the fruits or instrumentalities of a crime and that the items will be found in the place to be searched. ", "See, e.g., Zurcher v. Stanford Daily, 436 U.S. 547, 556-57, n. 6, 98 S.Ct. ", "1970, 56 L.Ed.2d 525 (1978). ", "Defendants do not allege that the Affidavit on which the warrant was based was facially insufficient for the Magistrate Judge's finding of probable cause. ", "I agree that as written it contains an ample probable cause showing. ", "They do, however, argue that had the Magistrate Judge known of attempts by AEG to find buyers for their listed properties, he would not have found probable cause. ", "They state, equivocally, that this is not a Franks argument, see Franks v. Delaware, 438 U.S. 154, 98 S.Ct. ", "2674, 57 L.Ed.2d 667 (1978), but cite no supporting cases for this proposition. ", "I believe that this is in essence a Franks argument, but is not born out by the facts.", "\nIn Franks v. Delaware, the Supreme Court held that it is a violation of the Fourth Amendment for an arrest warrant affiant to \"knowingly and intentionally, or with reckless disregard for the truth,\" include false statements in the affidavit. ", "438 U.S. 154, 155, 98 S.Ct. ", "2674, 57 L.Ed.2d 667 (1978). ", "The Tenth Circuit has extended this rule \"to material omissions, as well as affirmative falsehoods.\" ", "Stewart v. Donges, 915 F.2d 572, 582 (10th Cir.1990); see also United States v. Kennedy, 131 F.3d 1371, 1375 (10th Cir.1997). ", "Under Franks and Stewart, a defendant must show (1) that the affiant knowingly or recklessly either included affirmatively false statements or omitted material facts, and (2) that the affidavit, with its necessary corrections, would not support probable cause. ", "See Franks, 438 U.S. at 155-56, 98 S.Ct. ", "2674; Stewart, 915 F.2d at 582-83. ", "Where information has been omitted from an affidavit, a determination of probable cause is made \"by examining the affidavit as if the omitted information had been included and inquiring if the affidavit would still have given rise to probable cause for the warrant.\" ", "Stewart, 915 F.2d at 582 n. 13. ", "Additionally, a material omission negates the possibility that an otherwise invalid warrant will be spared from the exclusionary rule by the good faith exception in United States v. Leon. ", "An officer can \"have no reasonable grounds for believing that [a] warrant was properly *1265 issued\" \"[i]f the magistrate or judge in issuing a warrant was misled by information in an affidavit that the affiant knew was false or would have known was false except for his reckless disregard of the truth.\" ", "United States v. Leon, 468 U.S. 897, 923, 104 S.Ct. ", "3405, 82 L.Ed.2d 677 (1984).", "\nHere, however, neither prong of the Franks/Stewart test is met. ", "Defendants failed to show either that there were material misstatements or omissions in the Affidavit, or even if there were that such omissions negate probable cause.", "\n\n1. ", "Material Omissions\nDefendants failed to prove that material information was available to SA Mahon that was knowingly or recklessly omitted from the Affidavit. ", "SA Mahon admitted on cross-examination that he did not mention certain facts in the warrant. ", "He did not mention:\n(1) that PKH handed out a flyer to customers at its travel membership meetings stating that those people interested in buying time shares should contact AEG; (2) the existence of Larry Hubbard or the Colorado Data Systems office; (3) that AEG was advertising in national newspapers; (4) a 1994 training tape; (5) that a previous tip by Ms. Chancellor regarding a possible bank robbery suspect did not pan out; and (6) FBI visits to the AEG offices in October of 1995.", "\nAs to points (1) and (2), Defendants were unable to establish that SA Mahon knew about the flyer or Larry Hubbard prior to writing the Affidavit. ", "Point (4) is also not helpful, as Defendants did not establish any exculpatory information existed on the tape. ", "To the contrary, Defendants have themselves complained in other motions of the inflammatory nature of the training tape. ", "See Motions to Sever. ", "As to point (5), Ms. Chancellor's robbery tip is immaterial. ", "Her information in this case was independently corroborated by the FBI, and was unrelated to the earlier tip.", "\nTherefore, of the omitted information, arguably SA Mahon could have been expected to inform the Magistrate Judge that that AEG was advertising in national newspapers, and that FBI agents visited the AEG offices in October of 1995 when they were told that they could work through Ms. Peterson to buy a time share. ", "However, these facts were not misrepresented, nor was their omission material. ", "Other information in the Affidavit alludes to the newspaper ads, see Affidavit at 12, 30, and alleges that AEG used those ads solely to deflect allegations of fraud without any intent to actually engage buyers. ", "See Affidavit at 12. ", "As for the FBI visits to the AEG offices, the only possibly exculpatory information gathered was that the agent could go through Ms. Peterson to buy a time share. ", "However, this information was disclosed in the Affidavit. ", "See Affidavit at 37. ", "The Affidavit also states that SA Mahon went to the AEG offices in October of 1995. ", "It is unclear from the elicited testimony what other exculpatory evidence could lay in the October 1995 visits.", "\n\n2. ", "Negation of Probable Cause\nEven, if I were to find that these omissions were material, Defendants would still fail the Franks/Stewart test as they failed to show that had these omissions been included in the Affidavit they would have negated probable cause. ", "The Affidavit outlines with specificity the fraud scheme, including allegations that ERM was doing business as AEG. ", "See Affidavit at 4-7. ", "It outlines more than thirty complaints received by various government agencies regarding AEG and the similarities in those allegations. ", "It alleges that AEG completely failed to perform its guarantee to sell the properties. ", "See Affidavit at 4-7. ", "It then describes interviews with former employees. ", "The employees detail events that led them to suspect fraudulent business dealings, items they believed indicated the fraud (including script sheets, post-cards, Federal Express packages) and involvement in the fraud by Philip Peterson. ", "See Affidavit 7-16. ", "The bulk of the Affidavit describes interviews with victims. ", "The *1266 victims describe the representations made by AEG employees (sometimes by name of employee), guarantees by AEG to sell property quickly, requests by AEG for money, and instructions regarding how to send money to AEG through the mails or by Federal Express. ", "Some victims taped their conversations with AEG at the request of law enforcement, some sent money, and some sent no money and had no further dealings with AEG. ", "One complained repeatedly and received a refund. ", "See Affidavit 16-38. ", "The Affidavit then describes AEG offices and their location. ", "Finally, it indicates that Attachment B has been reviewed by a FBI Special Agent assigned to the Telemarketing Task Force investigating fraudulent telemarketing operations for verification that each item listed is generally found in such operations. ", "Read in its entirety, even with possible omissions included, the Affidavit clearly provides reasonable grounds to believe that the items sought to be seized were the fruits or instrumentalities of mail fraud, wire fraud, and aiding and abetting these crimes and that the items would be found in the Longmont AEG offices.", "\n\nB. Particularity requirement\nDefendants next argue that the warrant violates the particularity requirement of the Fourth Amendment. ", "As an adjunct to this argument, Defendants contend the warrant and search were overly broad.", "\nThe Fourth Amendment to the United States Constitution requires that warrants \"particularly describ[e] ... the persons or things to be seized.\" ", "This particularity requirement prevents a \"general, exploratory rummaging in a person's belongings.\" ", "Coolidge v. New Hampshire, 403 U.S. 443, 467, 91 S.Ct. ", "2022, 29 L.Ed.2d 564 (1971), overruled on other grounds, Horton v. California, 496 U.S. 128, 110 S.Ct. ", "2301, 110 L.Ed.2d 112. ", "It also forbids \"general searches ... and prevents the seizure of one thing under a warrant describing another. ", "As to what is to be taken, nothing is left to the discretion of the officer executing the warrant.\" ", "Stanford v. Texas, 379 U.S. 476, 485, 85 S.Ct. ", "506, 13 L.Ed.2d 431 (1965) (citations and quotations omitted); See also Andresen v. Maryland, 427 U.S. 463, 480, 96 S.Ct. ", "2737, 49 L.Ed.2d 627 (1976); United States v. Medlin, 842 F.2d 1194, 1199 (10th Cir.1988); Voss v. Bergsgaard, 774 F.2d 402, 404 (10th Cir.1985). \"", "The particularity requirement [also] ensures that a search is confined in scope to particularly described evidence relating to a specific crime for which there is demonstrated probable cause.\" ", "Voss, 774 F.2d at 404. ", "A companion doctrine to the particularity requirement requires the warrant not be overbroad and must identify the fruits and instrumentalities of the alleged crime. ", "See United States v. Harris, 903 F.2d 770, 775 (10th Cir.1990). ", "However, \"[t]echnical requirements of elaborate specificity once exacted under common law pleading have no proper place in this area.\" ", "United States v. Ventresca, 380 U.S. 102, 108, 85 S.Ct. ", "741, 13 L.Ed.2d 684 (1965). \"", "Where a warrant authorized the seizure of particularly described records relevant to a specific crime and all of an organization's records, in fact, fall into that category, they may all be seized.\" ", "Voss, 774 F.2d at 406. ", "Even a warrant that describes the items to be seized in broad or generic terms may be valid when the description is as \"specific as the circumstances and the nature of the activity under investigation permit.\" ", "Hargus, 128 F.3d at 1362-63, (citations and internal quotations omitted). ", "If law enforcement officers grossly exceed the scope of a search warrant in seizing property, the particularity requirement is undermined and a valid warrant is transformed into a general warrant \"thereby requiring suppression of all evidence seized under that warrant.\" ", "United States v. Medlin, 842 F.2d 1194, 1199 (10th Cir. ", "1988).", "\nDefendants first argue that the warrant fails the particularity requirement because it incorporates by reference Attachment A, a description of the offices to be searched, and Attachment B, a list of the items to be seized, but fails to specifically incorporate Attachment C, a description of the alleged *1267 fraud. ", "All three Attachments were included in the Affidavit and Application for search warrant. ", "Defendants argue that this was a generalized search under Voss, and the omission of Attachment C therefore violates United States v. Leary, 846 F.2d 592 (10th Cir.1988). ", "The government responds that the warrant was sufficiently particular, citing United States v. Finnigin, 113 F.3d 1182, 1186-87 (10th Cir.1997) and United States v. Hargus, 128 F.3d 1358, 1362-63 (10th Cir.1997). ", "These cases both found that the warrant at issue was sufficiently particular to \"allow the executing officers to distinguish between items that may and may not be seized.\" ", "Hargus 128 F.3d at 1362-63, (citing Finnigin, 113 F.3d at 1187, and Leary, 846 F.2d at 602).", "\nVoss concerned three IRS warrants to search a company suspected of conducting financial transactions on behalf of its clients in a manner designed to avoid detection by the IRS. ", "The warrants authorized the seizure of:\n\"all books, records or documents relating to the following: NCBE/NCE customer accounts; financial transactions; financial services; the purchase, sale, or storage of precious metals; employees; and marketing and promotions. ", "They further authorized the seizure of books, literature and tapes advocating nonpayment of federal income taxes; publications of tax protestor organizations; and literature relating to communications between persons conspiring to defraud the IRS, or to conceal such fraud.\"", "\nThe District Court found the warrants were so pervasive as to be invalid, as they gave \"carte blanche for government agents to take anything that they saw, whether it was nailed down or otherwise, and, indeed, as best I can find from the returns and the pleadings, that's precisely what did happen.\" ", "Voss v. Bergsgaard 774 F.2d 402, 404 (10th Cir.1985) (citations omitted). ", "The Tenth Circuit affirmed because the warrant was bounded only by reference to the federal conspiracy statute, 18 U.S.C. § 371. ", "The court found that the government could rummage through all files, \"seeking any information pertaining to any federal crime. ", "Even to describe the warrant as limited to evidence relating to federal crimes is an interpretation generous to the government.\" ", "Voss, 774 F.2d at 405. ", "The warrant was similarly executed in a broad manner, with agents seizing copies of the Internal Revenue Code, the Federal Rules of Criminal and Civil Procedure, and The Federalist Papers. ", "The Tenth Circuit held that there was insufficient evidence to show the target company was pervaded by fraud at every level, and therefore the warrant could not be saved on those grounds. ", "Voss, 774 F.2d at 406.", "\nLeary concerned an investigation into a single purchase and attempted exportation of a Micro-tel receiver to the People's Republic of China via six companies in Hong Kong. ", "United States v. Leary, 846 F.2d 592, 594 (10th Cir.1988). ", "Based on an affidavit alleging violations of the Arms Export Control Act and the Export Administration Act, a warrant was issued to search defendant's offices and seize:\nCorrespondence, Telex messages, contracts, invoices, purchase orders, shipping documents, payment records, export documents, packing slips, technical data, recorded notations, and other records and communications relating to the purchase, sale and illegal exportation of materials in violation of the Arms Export Control Act ... and the Export Administration Act of 1979....\nThe Court found this warrant to be constitutionally overbroad because it contained only two limitations. ", "First, the documents seized had to fall into a long list of business records typical of the documents kept by an export company. ", "Second, the documents had to relate to the \"purchase, sale and illegal exportation of materials in violation of the federal export laws.\" ", "Id. at 600.", "\nThe Leary court mentioned with approval several limiting factors which, if included in the warrant before it, would have rendered the warrant constitutional. ", "These factors, relevant to the warrant in *1268 this case, include: 1) limiting the seizure of documents to those which concern the crime(s) under investigation; 2) limiting seizure of documents to a specific period of time relating to the suspected crime(s); and 3) describing the criminal activities themselves rather than simply referring to the statute believed to have been violated.", "\nThe court went on to say that an Affidavit may cure an overbroad warrant, but only where the Affidavit and search warrant can reasonably be said to constitute one document. ", "Two requirements must be met. ", "First, the Affidavit and search warrant must be physically connected, and second the search warrant must \"expressly refer to the Affidavit and incorporate it by reference using suitable words of reference.\" ", "Leary, 846 F.2d at 603.", "\nBoth Voss and Leary are distinguishable from this case in several respects. ", "First, unlike those two cases, this was not a general warrant allowing seizure of all company records in their entirety. ", "Rather, the warrant specifies that the following information may be taken:\n(a) customer files, folders, or any other customer records.", "\n(b) Letters of complaint or other correspondence.", "\n(c) Telephone records including but not limited to: 800-831-3262, 800-277-3741; XXX-XXX-XXXX, and XXX-XXX-XXXX.", "\n(d) Records of receipts of mailings, whether by United State Postal Service, Federal Express, or other delivery type services.", "\n(e) Personnel and/ or pay records.", "\n(f) Bank, credit union or other financial institution statements; canceled checks or drafts, check ledgers, check books and any documents relating to the financial business of AEG, PKH and ERM.", "\n(g) Cash, personnel checks, money orders, cashier's checks, or any other negotiable instruments payable to or belonging to AEG, PKH, and ERM.", "\n(h) Business licenses, Public Service receipts or any other documents which establish the identity of the owners, principles [sic], agents and/ or establishes the dominion and control of such persons over the business of AEG, PKH, and ERM.", "\n(i) Scripts and/or sales pitch sheets pre-printed or hand written.", "\n(j) Lead source material, including the names, addresses and telephone numbers of prospective customers from purchased lead lists, subscriber lists, and business reply cards.", "\n(k) Sales order, invoices, bills of sale and sale logs.", "\n(l) Commission schedules.", "\n(m) Sales, procedure, and policy manuals.", "\n(n) Calendars and diaries.", "\n(o) Personnel files for owners, managers, and employees, past and present.", "\n(p) General journal, general ledger, accounts receivable and payable ledgers or records, sales journals, purchases journals, reflecting company business, to include documentation for entries therein.", "\n(q) Computer and related equipment, and operating manuals, floppy discs, printed computer reports, software packages, and any related electronic devices which are capable of analyzing, creating, displaying, converting, or transmitting electronic or magnetic computer impulses or data.", "\n(r) Any other documents or items which reflect the nature and/ or operation of the businesses as they relate to the crimes specified in this Affidavit, from August, 1994, to the present.", "\n(s) Identification paper and documents, legitimate or false, for persons associated with AEG, PKH, and/or ERM, including but not limited to: Thomas C. Graham, Jim Kelly, Elisa G. Sanchez, Phillip [sic] S. Peterson, and telephone solicitors.", "\n(t) Titles or other motor vehicle identification documentation.", "\nSecond, and also unlike Voss and Leary, the warrant here was executed in a manner consistent with Attachment C. All agents read the Affidavit and Attachments *1269 in their entirety before executing the search. ", "The Affidavits and Attachments were available at the scene and were constantly referenced in order to ensure that seizures remained with their parameters. ", "A review of the inventory shows that the items seized fell within the parameters of the warrant.", "\nThird, SA Dugo testified that agents viewed item (r), the time frame, as applying to all items seized. ", "Therefore, no items were taken that fell outside of the specified time frame, with the exception of customer files. ", "Those files, SA Dugo testified, were viewed as one piece of evidence. ", "The agents made the decision to seize entire customer files if any one piece of evidence within that file fell into the time frame. ", "She testified agents felt this was required in order to keep the evidence in its pristine state and prevent agents from dismembering files.", "\nAdditionally, the warrant shows those items the Leary court specifically stated would save an otherwise invalid warrant: (1) the seizure of documents was limited to those which concerned the crime(s) under investigation; (2) the seizure of documents was limited to a specific period of time relating to the suspected crime(s); and (3) the Affidavit and Attachment C were used during the search and described the criminal activities themselves rather than simply referring to the statute believed to have been violated.", "\nDefendants argue that warrants also serve a notice purpose and that purpose was failed because AEG did not receive a copy of the warrant and its attachments. ", "It is not contested that the contents of the warrant serve as notice to the searched as well as guidance for searchers. ", "Although AEG and its principals were not provided with the warrant and its attachments, this does not vitiate the otherwise valid search. ", "In this case the warrant was under seal. ", "Defendants point to no impropriety in sealing the warrant and its attachments. ", "In due course and when appropriate, the notice purpose was served by unsealing these documents. ", "Finally, no prejudice has been alleged or shown.", "\nDefendants next argue that the warrant and supporting documentation is not particular enough in that: (1) it fails to consider whether the companies had the ability to perform the legitimate business it purported to perform; (2) it fails to limit the items which may be seized; (3) it fails to distinguish between personal and business items; (4) it fails to distinguish between various business entities; (5) it fails to distinguish between telemarketing and other business activity; and (6) it fails to distinguish between fraudulent and legitimate telemarketing activity. ", "They argue that records were seized relating to Pass-Key Holidays, Inc. (PKH) and Eagle Rise Marketing (ERM) without supporting facts in the Affidavit showing a link between these companies and the fraud, that documents relating to legitimate business activities were seized, and that records of AEG's effort to launch a buying division with the cooperation of the North American Recreational Properties Association (NARPA) (the Larry Hubbard documents) were seized, prematurely ending both these efforts and a possible defense to the charges of fraud.", "\nThe government responds that the Affidavits and Attachments were sufficiently particular, because: (1) the companies' ability to perform the legitimate business they purported to perform is irrelevant, as the Affidavit clearly indicates that they were not in fact performing a legitimate business; (2) the warrant specifically limited items to be seized and the seizure itself was done with due regard for the warrant's boundaries; (3) personal items were not seized; (4) the Affidavit shows that ERM was a shell corporation doing business as AEG and while certain items related to PKH were seized, PKH's office at the Denver Tech Center was not searched; (5) it is not necessary to determine the knowledge of each employee before searching for items in that employee's work space related to the fraud and AEG *1270 was inherently fraudulent and illegal; and (6) there was no evidence of legitimate telemarketing, and no records relating to legitimate telemarketing were seized.", "\nThe government's arguments are born out both by the Affidavit supporting the warrant and the testimony of the agents at the hearing. ", "As explained in part A, supra, the Affidavit outlines with specificity the pervasive fraud scheme, including allegations that ERM was doing business as AEG. ", "See Affidavit at 4-7. ", "It outlines thirty complaints received by various government agencies regarding AEG, and the similarities in those allegations. ", "See Affidavit at 4-7. ", "It details interviews with former employees, including events that led them to suspect fraudulent business dealings, items they believed indicated the fraud, and involvement in the fraud by Philip Peterson. ", "See Affidavit 7-16. ", "It describes interviews with victims, including the details of the promises made in return for money.", "\nIt is also clear that the warrant was carefully executed. ", "Agents drew a map of the AEG offices, inventoried the contents of those offices, interviewed employees, and checked each item against the warrant before it was seized. ", "Throughout the search the agents were in contact with SA Mahon, SA Dugo, and AUSA Mackey by telephone, who assisted them in determining the boundaries of the warrant with reference to the Affidavit and all three Attachments. ", "A number of documents outside the parameters of the warrant were not taken, personal items were not taken, and except as legitimately noted, items outside the time frame of the fraud specified in the warrant were not taken. ", "A review of the inventory supports these assertions. ", "A detailed office diagram is included, and although the inventory is ninety pages long there are indications that some inventoried items were either not seized or were returned to employees.", "\nThe government concedes that records relating to NARPA were seized. ", "However, uncontroverted and credible testimony made clear that those documents were seized with the consent of Larry Hubbard in the presence of his attorney.", "\nI therefore find and conclude that this was not a generalized search as defined by Voss and Leary and comports with the Fourth Amendment in that the warrant was supported by probable cause, met constitutional particularity requirements, and was not grossly overbroad in its execution.", "\n\nC. Good Faith\nEven if I were to find that the warrant was not sufficiently particular, this search would be saved by the good faith exception articulated in United States v. Leon, 468 U.S. 897, 104 S.Ct. ", "3405, 82 L.Ed.2d 677 (1984); and Massachusetts v. Sheppard, 468 U.S. 981, 988, 104 S.Ct. ", "3424, 82 L.Ed.2d 737 (1984). ", "Under those two cases, any failure in particularity can be cured through objective good faith reliance on a facially valid warrant.", "\nThe government argues Leon and Sheppard would apply because the FBI relied on a facially valid warrant and that reliance was objectively reasonable. ", "Defendants seem to concede that the Leon test has been met, but argue that the \"real purpose of this warrant was merely to close down AEG,\" and, therefore, this is \"one of those `unusual' cases where suppression of evidence is appropriate to deter government misconduct ....\" (citing Leary, at 609).", "\nThe record is void of evidence of government misconduct. ", "SA Mahon testified credibly that any incorporation mistakes in the warrant were inadvertent. ", "The warrant went through regular review procedures in the FBI office and the U.S. Attorney's Office. ", "It was further reviewed by a neutral Magistrate Judge. ", "Any mistakes made in the wording of the warrant were fully countered by the manner in which the warrant was executed. ", "Agents acted as if they were bounded by the Affidavit and Attachment C, regardless of whether it was incorporated in the warrant. ", "Nor is there any evidence that the purpose of the search was to close down AEG. ", "To the *1271 contrary, SA Diehl testified that agents purposely left complete backup copies of AEG's file server. ", "Were AEG to buy, lease, or borrow a hard drive they would have complete use of their computer system. ", "Their phone system was left intact. ", "Uncontroverted photographs taken at the completion of the search show offices that remained relatively organized, with large amounts of paper documents and a phone system. ", "Indeed, AEG opened for business the next morning. ", "Suppressing items seized pursuant to the warrant would serve no valid purpose, as there was no untoward government behavior to deter.", "\nAccordingly, it is ORDERED that:\n(1) the motion to suppress business records, items, and documents seized pursuit to search warrant is DENIED.", "\n" ]

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[ "Egon Sørensen\n\nEgon Sørensen (February 16, 1913 - October 25, 1981) was a Danish amateur football goalkeeper and club manager, who played 18 games for the Denmark national football team. ", "Due to World War II, 6 of his last 9 internationals were matches against Sweden. ", "Sørensen spent his entire club career with BK Frem, playing 237 matches for the club.", "\n\nEgon Sørensen was a physically strong goalkeeper, able to play as an outfield player. ", "At Frem, he was well trained by the shots of international centre forward Pauli Jørgensen, who later became team coach. ", "Sørensen made his debut for the Danish national team in 1935, and competed with Aksel Daniel Nielsen and Ove Jensen to replace international veteran Svend Jensen. ", "They were all eventually eclipsed by Eigil Nielsen.", "\n\nSørensen was also a dedicated handballer, and represented the Denmark national handball team at the 1938 World Men's Handball Championship. ", "He worked as a boots and shoes dealer.", "\n\nHonours\nDanish Football Championships: 1935-36, 1940–41 and 1943–44 with Frem\n\nReferences\n\nExternal links\nDanish national team profile\n Boldklubben Frem profile\n\nCategory:1913 births\nCategory:1981 deaths\nCategory:Danish footballers\nCategory:Denmark international footballers\nCategory:Boldklubben Frem players\nCategory:Danish male handball players\nCategory:Danish football managers\nCategory:Køge BK managers\nCategory:Kolding IF managers\nCategory:Association football goalkeepers" ]

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[ "The pigments morph because of the ­Munker-​White illusion, which shifts the perception of two identical color tones when they’re placed against different surrounding hues. ", "No one knows for sure, but the illusion probably results from what David Novick, a computer scientist at the University of Texas at El Paso, calls the color-completion effect. ", "The phenomenon causes an image to skew toward the color of the objects that surround it. ", "In a black-and-white image, a gray element would appear lighter when it’s striped with white, and darker when banded with black." ]

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[ "<?", "php\n/*\n\tRyzom Core Web-Based Translation Tool\n\tCopyright (C) 2011 Piotr Kaczmarek <p.kaczmarek@openlink.pl>\n\n\tThis program is free software: you can redistribute it and/or modify\n\tit under the terms of the GNU General Public License as published by\n\tthe Free Software Foundation, either version 3 of the License, or\n\t(at your option) any later version.", "\n\n\tThis program is distributed in the hope that it will be useful,\n\tbut WITHOUT ANY WARRANTY; without even the implied warranty of\n\tMERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. ", " See the\n\tGNU General Public License for more details.", "\n\n\tYou should have received a copy of the GNU General Public License\n\talong with this program. ", " If not, see <http://www.gnu.org/licenses/>.", "\n*/\n?", ">\n<?", "php\nclass User extends AppModel {\n\tvar $name = 'User';\n\tvar $displayField = 'name';\n\n\tvar $actsAs = array('Null' => array('confirm_hash'));\n\n\tvar $recursive = 0;\n\n\tvar $validate = array(\n\t\t'username' => array(\n\t\t\t'alphaNumeric',\n\t\t\t'uniqueCheck' => array(\n\t\t\t\t'rule' => 'isUnique',\n\t\t\t\t'message' => 'That username has already been taken.',", "\n\t\t\t),\n\t\t),\n\t\t'email' => array('rule' => 'email', 'message' => 'Wrong format'),\n\t\t'name' => array('rule' => 'notEmpty'),\n//\t\t'password' => array('rule' => 'notEmpty'),\n\t\t'passwd' => array('rule' => 'notEmpty'),\n\t);\n\n\tvar $scaffoldForbiddenActions = array(\"add\", \"edit\", \"delete\");\n\tvar $scaffoldForbiddenFields = array(\"\" => array(\"activated\",\"password\",\"confirm_hash\",\"created\",\"modified\"),/* \"admin_\" => array(\"password\")*/);\n\n\tvar $hasMany = array(\n\t\t'Translation' => array(\n\t\t\t'className' => 'Translation',\n\t\t\t'foreignKey' => 'user_id',\n\t\t\t'dependent' => false,\n\t\t\t'conditions' => '',\n\t\t\t'fields' => '',\n\t\t\t'order' => '',\n\t\t\t'limit' => '',\n\t\t\t'offset' => '',\n\t\t\t'exclusive' => '',\n\t\t\t'finderQuery' => '',\n\t\t\t'counterQuery' => ''\n\t\t),\n\t\t'Vote' => array(\n\t\t\t'className' => 'Vote',\n\t\t\t'foreignKey' => 'user_id',\n\t\t\t'dependent' => false,\n\t\t\t'conditions' => '',\n\t\t\t'fields' => '',\n\t\t\t'order' => '',\n\t\t\t'limit' => '',\n\t\t\t'offset' => '',\n\t\t\t'exclusive' => '',\n\t\t\t'finderQuery' => '',\n\t\t\t'counterQuery' => ''\n\t\t),\n\t\t'Comment' => array(\n\t\t\t'className' => 'Comment',\n\t\t\t'foreignKey' => 'user_id',\n\t\t\t'dependent' => false,\n\t\t\t'conditions' => '',\n\t\t\t'fields' => '',\n\t\t\t'order' => '',\n\t\t\t'limit' => '',\n\t\t\t'offset' => '',\n\t\t\t'exclusive' => '',\n\t\t\t'finderQuery' => '',\n\t\t\t'counterQuery' => ''\n\t\t),\n\t);\n\n}\n" ]

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[ "Corrections and clarifications.", "\nMarcia Barinaga's 1 July Research News article \"Knockout mice: Round two\" (p. 26), did not mention that Alexandra Joyner's collaborator on the brain cell fate mapping experiment is Eric Mercer, in David Anderson's laboratory at Caltech." ]

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[ "Starting May 30th ⁦⁦ @TheTwilightZone ⁩ will be available in black and white. ‘", "Cause... come on. ", "https://t.co/7h5LdjUszr" ]

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[ "The fact that you aroused that much controversy, to have so many people debate its success, means in fact you did succeed. ", "At least to me anyway.", "\n--\n\nI'm a 22 year old cadet ready to graduate and serve as a platoon leader in the US Army that has an extremely voracious apetite for backpacking and adventure. ", "I am also finally feeding my passion for photography while working on the fluency of my two languages other than English: Spanish and Arabic." ]

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[ "\" Don't you think you ought to get goin'?\" \" ", "Something's not adding up here.\" \"", "You can bring down Gerhardt Bronck's evil empire tomorrow.\" \"", "Tonight you got a date.\" \" ", "It's not a date.\" \" ", "She's making you dinner.\" \"", "Well...\" \"I gotta figure this thing out.\" \" ", "So I'm just gonna have to cancel.\" \" ", "At the last minute?\" \"", "I have work to do.\" \"", "Max'll understand.\" \"", "No, she won't.\" \"", "She's female, in case we hadn't noticed.\" \"", "Fine.\" \"", "I'll just reorganise my entire life cos some girl wants to cook dinner for me.\" \"", "That's kinda how it works.\" \"", "How civilisation happened.\" \"", "And she's not \"some girl\".\" \"", "Tell me about it.\" \"", "When the water starts to boil, you put the pasta in.\" \" ", "I hope I can pull this off.\" \" ", "Max, you can do this.\" \"", "I watched you rebuild a motorcycle in under two hours.\" \" ", "Different skill set.\" \" ", "Trust me.\" \"", "After Logan tastes this tricolore sauce I whipped up, he will be your sex slave.\" \"", "We don't have that kind of relationship.\" \"", "Yet.\" \"", "I'm just reciprocating for all the times he's cooked for me.\" \"", "OK.\" \"", "Answer me one question, though.\" \"", "Where did you find cold-pressed virgin olive oil from Tuscany, in this economy?\" \"", "I broke into the Italian Embassy.\" \"", "I'm gonna disappear so you can take all the credit here.\" \" ", "Hi.\" \" ", "Where?\" \"", "When?\" \" ", "Great seeing you.\" \" ", "OK.\" \"", "Thanks.\" \"", "Hey, Kendra.\" \"", "Hey.\" \"", "You bring the wine?\" \"", "Yeah.\" \"", "Um...\" \" Listen, that was a contact of mine.\" \" ", "Pre-Pulse.\" \"", "Nice.\" \"", "He gave me a tip on that guy Bronck who's ripping off the city's blood supply and moving it out of the country.\" \" ", "These OK?\" \"", "I don't have any wine glasses.\" \" ", "Yeah, they're fine.\" \"", "But we need to get out to Furrow airfield to do some recon.\" \"", "I'll swing it tomorrow after work.\" \"", "I hope you like pasta tricolore.\" \"", "I love it.\" \"", "But tomorrow's no good because we gotta go...\" \"No!\" \"", "Don't do that.\" \"", "Right.\" \"", "You do it.\" \"", "I always break the cork.\" \"", "No, I just mean it'll go bad if we don't drink it right away.\" \" ", "Oh.\" \"", "I'm game if you are.\" \" ", "Max, haven't you heard a word I've said?\" \" ", "We gotta do this tonight.\" \" ", "OK, I'll put the pasta on.\" \"", "We gotta go.\" \"", "Now.\" \" ", "Now?\" \" ", "Yeah.\" \"", "Now.\" \"", "So, you know, get changed or whatever and I'll wait for you downstairs.\" \"", "One reason Bronck's hard to pin down is he uses different airstrips every shipment.\" \"", "My contact says the next one's going out of Furrow airfield tomorrow night.\" \"", "He's moving stolen blood, so look for refrigeration equipment.\" \"", "Max!\" \"", "This is important.\" \"", "There are people dying because of what Bronck's doing.\" \" ", "I almost died.\" \" ", "I had your back on that.\" \"", "Not everybody has a genetically-engineered universal donor looking out for 'em.\" \" ", "What kind of security am I running into?\" \" ", "According to my source, next to nothing.\" \"", "Bronck is either keeping a low profile or he's so insulated by the cops he doesn't need to worry.\" \"", "Let's get this bitch over with.\" \"", "Hey!\" \"", "You there!\" \"", "Get back here!\" \"", "Hey!\" \"", "Don't even think of speaking to me.\" \"", "You said there'd hardly be any security.\" \" ", "My guy screwed up.\" \" ", "No kidding.\" \"", "Did you see any refrigeration equipment?\" \"", "No.\" \"", "From the firepower we saw, Bronck's smuggling more than medical supplies.\" \"", "The guy's got his fingers everywhere.\" \"", "Gunrunning, racketeering, prostitution.\" \"", "Anything could have been on that plane.\" \"", "Great.\" \"", "I risk my life and I don't even know what for.\" \"", "My intelligence wasn't accurate.\" \"", "It won't happen again.\" \"", "Damn straight it won't.\" \"", "Cos I'm done.\" \"", "What do you mean, \"done\"?\" \"", "This guy's up to something very bad, Max.\" \"", "I can feel it.\" \" ", "Not my problem.\" \" ", "That's a selfish way of looking at things.\" \"", "Yeah, well, we can't all be obsessed with saving the freakin' world.\" \" ", "I'm not obsessed.\" \" ", "It's all you think about.\" \"", "All you talk about.\" \" ", "At least I care about other people.\" \" ", "You care about strangers anyway.\" \"", "What about our quid pro quo?\" \"", "You still want me to look into Manticore?\" \"", "No.\" \"", "Looking for those kids has gotten me nothing but trouble.\" \"", "You can't let go of Manticore any more than I can let go of Eyes Only.\" \"", "It's who we are.\" \"", "If you think you were put on Earth to be the world's most pissed-off TV reporter and hide behind a silly red, white and blue Hallowe'en mask, I feel sorry for you.\" \"", "If you were put on Earth to be the world's biggest cynic and hide behind some tough-ass attitude, then I feel sorry for you.\" \"", "You know what, Logan?\" \"", "How about a new quid pro quo?\" \"", "Don't call me.\" \"", "I won't call you.\" \"", "What is up with Normal this morning?\" \"", "He's flossing, literally.\" \"", "Somethin' strange is going on.\" \"", "He smells like lilacs.\" \"", "He told Peabo he was splitting from work early.\" \"", "What, Normal's leaving work early?\" \"", "Now there's a first.\" \"", "Why is it guys are all so task-oriented?\" \"", "I mean, it's work, work, work, work, work.\" \"", "Cos otherwise all we'd think about is sex, sex, sex, sex, sex.\" \"", "Maybe Normal's got a date.\" \"", "That's just a bizarre thought - Normal gettin' busy with someone.\" \" ", "Do we really think he has a woman?\" \" ", "There's somethin' goin' on.\" \" ", "Max, let's go check it out.\" \" ", "All right.\" \" ", "You look nice today.\" \" ", "Thank you.\" \"", "Going to a funeral?\" \"", "No.\" \"", "Lilac.\" \"", "So how come you're all macked out like a playa playa?\" \"", "The reason it's called a personal life is cos it's personal.\" \"", "Here.\" \"", "Hot run, 930 lliff.\" \"", "Beat it.\" \"", "Away you go.\" \"", "Booty call.\" \"", "It's Gerhardt Bronck and one of his operatives.\" \"", "Bronck's street muscle collecting protection money, which is being laundered through this place.\" \"", "Pretty pictures.\" \"", "But Eyes Only won't move on this unless we give him supporting documentation.\" \"", "It's all there.\" \" ", "Where'd you get this?\" \" ", "One of my sources in the DA's office.\" \" ", "They dropped the case.\" \"", "Lack of evidence.\" \" ", "Smells like a buyoff.\" \"", "You figured out what Bronck's smuggling?\" \"", "Not yet, but there's enough here for Eyes Only to amp up the pressure on him publicly.\" \"", "Embarrass him.\" \"", "People start paying attention, maybe he makes a mistake...\" \"What did you find out last night at the airstrip?\" \"", "When some girls don't eat dinner they get real cranky.\" \"", "Men.\" \"", "They just don't have the mental or emotional capacity to make a real connection.\" \"", "You're better off kicking it with some gorgeous slow-witted stud who you can send on his way.\" \" ", "I'm swearing off the whole gender.\" \" ", "I tried that.\" \"", "You will so hate your life.\" \"", "There is Sosh...\" \"He's a student.\" \"", "Too smart.\" \"", "Haj is cute... but he's a computer analyst.\" \"", "Sven.\" \"", "Big Norwegian.\" \"", "Hauls nets on an Alaskan fishing rig.\" \"", "On shore leave for two, maybe three more days, tops. ", "6' 4\", eyes like the ocean.\" \"", "Thanks, but no thanks.\" \"", "See you at Crash tonight?\" \"", "I'll be there.\" \"", "Seven.\" \"", "Eight.\" \"", "Nine.\" \"", "Come on, you can do it.\" \"", "Ten.\" \"", "Argh!\" \" ", "Rest a couple of minutes, then we'll finish.\" \" ", "No.\" \"", "I'm done.\" \" ", "Two more sets.\" \" ", "I said I'm done.\" \" ", "Wanna tell me what's with you today?\" \" ", "Same thing that's with me every day.\" \"", "Reps, more reps, pep talks about patience and mind over matter, and I'm sick of it.\" \"", "You and Max have a spat?\" \"", "Feelin' sorry for yourself?\" \"", "Max has nothing to do with it.\" \"", "My legs don't work.\" \"", "And that's never gonna change.\" \"", "If I ever hear you talk like that again,\" \"I will beat on your skinny ass - wheelchair or no wheelchair.\" \"", "You understand?\" \"", "Let's go again.\" \"", "One.\" \"", "Two.\" \" ", "Mr Ronald.\" \"", "So happy to see you.\" \" ", "Oh, hold the phone, Jorge.\" \" ", "You do not dine alone tonight?\" \" ", "No, I do not dine alone.\" \"", "A lady, perhaps?\" \"", "I'll say.\" \" ", "Hi, Louise.\" \" ", "Have you been waiting long?\" \"", "Only a lifetime.\" \" ", "This place is so interesting.\" \" ", "An old haunt.\" \"", "I met Jorge back when I was doing my PhD at Harvard.\" \"", "He ran a bistro in the square then.\" \"", "But, well, we all have our tales of woe.\" \"", "You have a PhD?\" \" ", "Yes, several.\" \" ", "You really are a remarkable man, Reagan.\" \"", "Please, call me Ray.\" \"", "But enough about me.\" \"", "I wanna hear your story.\" \"", "The first two acts left me wanting so much more.\" \"", "Not much else to tell.\" \"", "Just a girl from the Midwest trying to get by in a broken world.\" \" ", "And doing so with style and grace.\" \" ", "You're sweet.\" \"", "Jorge's best.\" \" ", "For Mr Ronald, and his beautiful...\" \" Thank you.\" \"...", "lady friend.\" \" ", "Enjoy.\" \" ", "Thank you.\" \"", "To our second date.\" \"", "I gotta tell you, when I first saw you at that sector checkpoint\" \"I didn't think a guy like me could be a dog walker for a gal like you.\" \"", "Stop.\" \"", "I can't believe a man like you is unattached.\" \"", "I've been waiting for a long time for the right someone to come along.\" \"", "I don't understand women who need a man to make them feel complete.\" \"", "Put the bullet right here.\" \"", "Surprise surprise!\" \"", "Max, this is Sven.\" \"", "Hello, Mac.\" \"", "Hi.\" \"", "Sometimes a tight six-pack and a good set of shoulders help take the edge off.\" \"", "Do not attempt to adjust your set.\" \"", "This is a Streaming Freedom Video bulletin.\" \"", "Actually, I'm not really into partying right now.\" \"", "See ya.\" \" ", "Bye, Mac.\" \" ", "Bye.\" \"...", "free voice left in this city.\" \"", "There is a cancer in Seattle and its name is Gerhardt Bronck.\" \"", "You've seen his picture in the newspaper, heard him described as a businessman.\" \"", "A philanthropist, even.\" \"", "Make no mistake, he is a thug whose crime machine preys on the citizens of this community.\" \"", "What you are about to see is just the tip of the iceberg.\" \"", "That is not good, him jamming us up like that on TV.\" \" ", "This is what we wanted to happen.\" \" ", "What if the DA sees it and comes after us?\" \"", "The DA doesn't unzip his fly without checking with me.\" \"", "Still, bad publicity.\" \"", "Who gives a rat's ass as long as it gives us Eyes Only?\" \"", "So which of the three cops we set up thinks he's a boy scout?\" \"", "The Korean guy, Matt Sung.\" \" ", "You want us to pick him up?\" \" ", "No.\" \"", "He's got to be communicating with Eyes Only through an intermediary.\" \"", "I want you to feed this wink something else on me.\" \"", "Then we watch him.\" \"", "See who he shares the birthday cake with.\" \"", "And then we squeeze the living crap out of him until he gives us his boss.\" \"", "So, that was Eyes Only.\" \"", "Over and out.\" \"", "Jorge.\" \"", "Your lady friend left her purse last night.\" \"", "That's so sweet.\" \"", "You didn't have to come.\" \"", "I could've sent one of my kids.\" \"", "For an old friend, good customer, and his beautiful female companion... no problem.\" \"", "Oh, thank you, amigo.\" \"", "Very sweet.\" \"", "All right, we'll see you tonight, OK?\" \"", "Seven o'clock, regular table.\" \" ", "Adios.\" \" ", "Adios.\" \"", "I mean, you never hear women talking about leaving a legacy or worrying about their place in history.\" \"", "What's that about?\" \"", "Your entire gender think they're on some mission.\" \"", "It is hurting on my brain, trying to figure out who on earth would go out with Normal.\" \"", "There's a lot of freaks out there.\" \"", "So, who's comin' with me on this run?\" \"", "Well, come on, guys.\" \"", "Clemson Street is deep in Rydin Forties' turf.\" \" ", "So?\" \" ", "So there's permanent gang wars going on.\" \" ", "Please?\" \" ", "You are such a wuss.\" \"", "Let's go.\" \"", "I have a run. ", "4711 Kings Road.\" \" ", "I'm on break.\" \" ", "Well, whenever you get a chance.\" \"", "You OK?\" \"", "It's a personal run, so be nice.\" \"", "In defence of my gender, women come into the world with a mission, which is to make offspring.\" \"", "Men have to find a mission, create things.\" \"", "Space travel...\" \"Space travel, the carburetted bong...\" \"I know a guy who breathes through his anus by threading aquarium tubing in his colon...\" \"You know what?\" \"", "I am beginning to think that Normal's right.\" \"", "You are an idiot.\" \"", "Come on!\" \"", "What's the number on this thing?\" \"", "It's 7657380423611.\" \"", "OK.\" \"", "I'll call.\" \"", "A package for Tacoma Bleed.\" \"", "Are you Mr Bleed?\" \"", "It's a return receipt request.\" \"", "I need a signature.\" \"", "Yo, Bleed, a package.\" \"", "Need a signature, yo.\" \"", "Thanks.\" \"", "Hold up.\" \" ", "Is that a finger?\" \" ", "Who sent this?\" \"", "It was a pick-up on the east side.\" \"", "Blunt Ryddim Kidz turf.\" \"", "They got Li'I Throttle, cos that's his ice.\" \" ", "We gotta go to war, dog.\" \" ", "Don't kill the messenger.\" \"", "Check this out.\" \"", "You and Gilligan better get on up out of here.\" \"", "Cos starting' right now, anybody ain't claimin' the same set as me is goin' down quick.\" \" ", "And wet.\" \" ", "Great.\" \"", "Another man on a mission.\" \" ", "Yeah, right.\" \" ", "Let's bounce.\" \" ", "Hello?\" \" ", "Hey, Logan.\" \" ", "Hey, Matt.\" \"", "Your contact turn up anything?\" \" ", "I think your guy will be pleased.\" \" ", "OK.\" \"", "Meet you in the park in an hour.\" \" ", "All right.\" \"", "Sketchy, how did you manage to escape from being a male obsessed with his career?\" \"", "Hey, just because at present I happen to be stuck in a dead-end job with no prospects, doesn't mean I don't have larger ambitions.\" \"", "I'd like to run my own business someday.\" \"", "Somethin' like Power Nipple.\" \"", "911, cos Mommy's got the 411 on Normal's shortie.\" \" ", "Do tell.\" \" ", "OK.\" \"", "So, Original Cindy's en route to sister girl's crib to deliver her purse, right?\" \"", "Then I think to myself, \"What kind of female forgets her purse?\"\" \"", "I wrestle my conscience for a minute.\" \"", "Then I decide to take a peek.\" \" ", "You went into her purse?\" \" ", "Hell, yeah!\" \"", "You wanna know everything about a female, where do you look?\" \" ", "That's invasion of privacy.\" \" ", "Crossin' the line, if you ask me.\" \"", "You wanna know what I found out or what?\" \" ", "Spill it.\" \" ", "Immediately.\" \"", "So, Original Cindy finds a prescription made out for Louise Klein for Premarin.\" \" ", "What's that?\" \" ", "Oestrogen, basically.\" \"", "Yeah?\" \"", "So?\" \"", "Then Original Cindy finds Louise Klein's driver's licence.\" \"", "Only it says that Louise Klein is Louis Klein.\" \" ", "You mean, like, a typo.\" \" ", "I mean, like, a former male.\" \" ", "Normal's chick is a dude?\" \" ", "Was a dude.\" \"", "Come on.\" \"", "Maybe she's got a brother or something.\" \"", "No, girl.\" \"", "The part of Kings Road where she lives is very gender-friendly.\" \"", "It's where all the mista sistas reside.\" \"", "The lesbian mind could get tampered with in that neighbourhood.\" \"", "This and a human finger all in the same day.\" \"", "It's deep.\" \" ", "For real.\" \" ", "For real, for sure.\" \"", "Louise comes to the door wearing a towel, right out of the shower.\" \"", "I'm clockin' her for nose hair, Adam's apple, miscellaneous male debris.\" \"", "The bitch is fine.\" \" ", "Even got back.\" \" ", "Do we think Normal knows?\" \"", "Oh, he's gonna find out.\" \"", "Which will be the entertainment spectacular of a lifetime.\" \"", "This is proof that the DA's on Bronck's payroll.\" \"", "Right.\" \"", "You give that to Eyes Only, he ought to be able to put Bronck away for good.\" \"", "Yeah, that's great, Matt.\" \"", "Thank you.\" \"", "What?\" \"", "Are you OK?\" \"", "Yeah.\" \"", "You've known me a while.\" \"", "Would you describe me as \"obsessed\"?\" \"", "Let's take a ride.\" \" ", "Get up!\" \" ", "Bling!\" \"", "Bling!\" \"", "Hey!\" \" ", "Get the door.\" \" ", "Take it easy.\" \"", "You know there's a curfew.\" \"", "You're gonna have to come down to the station.\" \"", "Then we'll call your folks.\" \"", "Don't worry.\" \"", "Hey!\" \" ", "Leave a message.\" \" ", "Logan, it's me.\" \"", "I think I know what Bronck's up to.\" \"", "He's got cops on his payroll.\" \"", "They're pickin' up kids off the street.\" \" ", "Max.\" \" ", "Let me talk to Logan.\" \"", "I can't.\" \"", "Bronck's got him.\" \"", "No ID.\" \"", "What's that, an Eyes Only thing?\" \" ", "The boss is a privacy nut.\" \" ", "What's he got against me?\" \"", "Plastering my face all over the TV?\" \"", "My mother is starting to worry.\" \"", "She should.\" \"", "It's dangerous being a bad guy.\" \"", "Oh, no.\" \"", "It's much more dangerous being the good guy.\" \"", "Which your boss is about to find out.\" \"", "Tell me who he is.\" \"", "I wish I could help you, but I've never met the man.\" \"", "I was wondering when we'd get to the hitting part.\" \"", "As much as I'd like to smack you around until you tell me, I just don't have a lot of time.\" \"", "Let's just cut to the chase, shall we?\" \"", "Tell me who he is.\" \" ", "All set.\" \" ", "Let him go.\" \" ", "Stop it.\" \" ", "Who is Eyes Only?\" \" ", "Please stop it.\" \" ", "Tell me.\" \"", "All right, I'll tell you.\" \"", "I'll tell you!\" \"", "Who is Eyes Only?\" \"", "Who is Eyes Only?\" \"", "I am.\" \"", "I'm Eyes Only.\" \" ", "Did you get your purse OK?\" \" ", "Yes.\" \"", "Thanks.\" \"", "Ray, there's something you need to know about me.\" \" ", "Louise...\" \" Let me say it.\" \"", "You don't need to say it.\" \"", "I know.\" \"", "You know?\" \" ", "What?\" \" ", "That you're, uh, someone, um...\" \"How do I put it?\" \"", "Who's had some aftermarket work done.\" \"", "That is to say, you've undergone a fairly substantial... retrofit.\" \"", "So you know I used to be a guy?\" \" ", "How did you find out?\" \" ", "Louise, you may have noticed I am a keenly intuitive, highly observant person.\" \"", "You went through my purse.\" \"", "Yes.\" \"", "My impulse to unravel the mystery that is you overwhelmed my deep reverence for private property.\" \"", "I'm sorry.\" \"", "I thought about this long and hard and I...\" \"I realised it doesn't matter.\" \"", "You know, it's 2020, I'm a modern man.\" \"", "And you're a... you know, newly-minted babe.\" \"", "You're as sexy as all get-out.\" \"", "It means a lot to me that you understand and accept me for who I am.\" \" ", "Vive la différence.\" \" ", "But that's not what I was going to tell you.\" \"", "It's not?\" \"", "I've realised something about myself these past few days that we've spent together that's gonna change things between us.\" \"", "I've thought about this long and hard and I'm telling you, there is absolutely nothing you can say that would change my feelings about you.\" \"", "I'm gay.\" \"", "In what sense?\" \"", "I'm a lesbian, Ray.\" \"", "Oh, for the love of Mike.\" \" ", "Bling?\" \" ", "In here.\" \" ", "What happened?\" \" ", "He had a meet with Sung.\" \"", "Bronck grabbed him.\" \"", "I tried to get to him, but...\" \"What are you doing?\" \"", "When Logan let me in on Eyes Only, he made me promise if anything happened to him,\" \"I'd protect the informant net by making sure the files didn't fall into the wrong hands.\" \"", "Lot of hard work... gone.\" \" ", "Which he'll regret when he gets back.\" \" ", "Max, he may not be coming back.\" \"", "Yes, he is, and that scumbag Bronck is goin' down hard.\" \"", "He gave you the codes and passwords, right?\" \"", "Yeah.\" \"", "What are you gonna do?\" \"", "What I always do.\" \"", "Make it up as I go along.\" \"", "Say it, like you do on TV.\" \"\"", "Do not attempt... to adjust your set.\"\" \"", "Oh dear, it looks like we're going to have to refry Detective Won Ton.\" \"", "Do not attempt to adjust your set.\" \"", "This is a Streaming Freedom Video.\" \"", "It cannot be traced, it cannot be stopped and it is the only free voice left in this city.\" \"", "It is him.\" \"", "The plane will be here in 15 minutes.\" \"", "We picked up a nice sampler for our friends overseas.\" \"", "Something for every taste.\" \"", "Load them up when the plane gets here.\" \" ", "What are you up to, Bronck?\" \" ", "I thought you had all the dirt on me.\" \"", "Well, there's just so much of it, it's hard to keep up.\" \"", "You are going to give me everything you have on my operation.\" \"", "In fact, you'll give me everything you have, period.\" \"", "You have the goods on a lot of people.\" \"", "Could be handy for someone in my line of work.\" \"", "I've got nothing to give up.\" \"", "Not any more.\" \"", "My people are under orders to destroy the informant net if anything happens to me.\" \"", "Am I supposed to believe that?\" \"", "It's the truth.\" \"", "I can't give you what I don't have.\" \" ", "I'm telling you the truth.\" \" ", "Sayonara.\" \"", "No!\" \"", "Do not attempt to adjust your set.\" \"", "This is Streaming Freedom Video.\" \"", "The cable hack will last exactly 60 seconds.\" \"", "It cannot be traced, it cannot be stopped, and it is the only free voice left in this city.\" \"", "This is Eyes Only speaking to Gerhardt Bronck.\" \"", "You are holding two of my operatives, Mr Bronck.\" \"", "I want them back.\" \"", "You will be contacted.\" \"", "That's my phone.\" \"", "I'm guessing it's for you.\" \"", "Shut these two up.\" \"", "Trace the call.\" \"", "I'm gonna nail this bastard once and for all.\" \" ", "Yes?\" \" ", "This is Eyes Only.\" \"", "That's odd.\" \"", "I have someone here who claims that he's Eyes Only.\" \"", "It's what my operatives are trained to do, to protect the informant net.\" \"", "And are they trained to do impressions as well?\" \" ", "I want my operatives.\" \" ", "And I want you off my back.\" \"", "Turn over all you have on me, call off your hounds, and I'll think about releasing your friends.\" \"", "Not good enough.\" \"", "My cable hacks are making it tough for you to do business.\" \"", "You want them to stop, it's going to cost you a hundred large.\" \"", "I said I have your friends here.\" \"", "And I've got enough on you to put you away for life.\" \"", "Are you trying to shake me down?\" \"", "I'm looking to cut a deal.\" \"", "So, Eyes Only is a playa.\" \"", "I prefer to think of myself as a businessman, like you.\" \"", "What about your \"Make the world a better place\" rap?\" \"", "Doesn't pay the bills.\" \"", "So do we have a deal?\" \"", "I got an address.\" \" ", "Let me consider it.\" \" ", "You've got 20 minutes.\" \" ", "Hope you know what you're doin'.\" \" ", "So do I.\" \"Get the files.\" \"", "Torch the place.\" \"", "And before you kill him, make sure you gouge his eyes out.\" \"", "I said I have your friends here.\" \"", "I've got enough on you to put you away for the rest of your life.\" \"", "You hear that?\" \"", "Sounds like an airplane engine in the background.\" \"", "These guys are rotating their operation through a network of abandoned airstrips.\" \"", "Question is, which one?\" \"", "I have your friends here.\" \"", "Let's go.\" \"", "I have your friends here.\" \"", "I have your friends here.\" \"", "Let me consider it.\" \"", "Bling!\" \" ", "What are you doing in my apartment?\" \" ", "You're on the wrong floor, Mrs Moreno.\" \" ", "Yeah?\" \" ", "Yo, Bleed.\" \" ", "Who is this?\" \" ", "Word.\" \"", "Bad guys with guns got sent to your place to kill people.\" \" ", "Just givin'you the heads up.\" \" ", "Is that right?\" \"", "Good lookin' out.\" \"", "This 134 Clemson?\" \"", "Let me consider it.\" \"", "Sounds like a foghorn.\" \"", "Could be Warton airfield, out by the harbour.\" \"", "What the hell is going on?\" \"", "They should have checked in by now.\" \" ", "We are ready to roll.\" \" ", "The money is on the plane.\" \"", "Meet you there.\" \"", "Shoot them.\" \"", "This is the last shipment.\" \"", "It was nice doing business with you boys.\" \"", "I've got to stop the plane.\" \"", "Aren't you forgetting something?\" \"", "Our money?\" \"", "OK!\" \"", "Let's go!\" \"", "Do you have a boarding pass?\" \"", "Turbulence.\" \"", "It's gonna be OK.\" \"", "Hot run. ", "95 Round Hill Road.\" \"", "Speaking of hot runs... was that your shugga I delivered to on Kings Road yesterday?\" \" ", "I said it's a hot run.\" \"", "Beat it.\" \" ", "Come on, talk to me, Normal.\" \"", "Original Cindy understands the human heart.\" \"", "Well, we had a moment, or so I thought, and, uh, it passed.\" \"", "You liked her, huh?\" \"", "Yeah.\" \" ", "What happened, if I'm not out of line?\" \" ", "Different interests.\" \"", "I enjoy the company of women, and apparently so does she.\" \"", "I feel you.\" \"", "Actually, she asked me to, uh, give you her number.\" \"", "She found you \"alluring\", I think was the word.\" \" ", "This bitch is gettin' you to pimp for her?\" \" ", "I am in the messenger business.\" \"", "The right one's out there for you somewhere, Normal.\" \"", "Yeah.\" \"", "Well, I shouldn't be pouring out my heart on company time.\" \"", "You better get goin'.\" \"", "So?\" \"", "Damn!\" \"", "Normal just gave me that half-a-heifer's phone number.\" \"", "Well, you gonna call her?\" \"", "Uh-uh.\" \"", "Cos when you get right down to it\" \"Original Cindy's just too damn straight to kick it with a science-fiction girlfriend.\" \"", "You were right about Bronck.\" \"", "Great place, America.\" \"", "Kid's walking home from school.\" \"", "Next thing she knows, she belongs to the highest bidder, working in a brothel on the other side of the world.\" \" ", "And Bronck makes a killing every planeload.\" \" ", "And I almost let him get away with it.\" \"", "The bottom line is, he's out of business.\" \"", "You did good.\" \"", "I wish I could have done something about those kids on the plane that other night.\" \"", "Got a lead they're being held by a middleman in LA.\" \"", "Got some people on it.\" \"", "So, do I finally get my Eyes Only secret decoder ring?\" \"", "Listen.\" \"", "I'm sorry about the other night.\" \"", "I, uh...\" \"I guess I have been a little too focused on my mission.\" \"", "I don't know, maybe Eyes Only has been a way of not having to, uh... think about the less pleasant aspects of my life.\" \"", "Maybe it is a Hallowe'en mask I've been hiding behind.\" \"", "You don't have to.\" \"", "Not from me.\" \"", "I've got everything we need to whip up a pasta tricolore.\" \" ", "I can boil the water.\" \" ", "You can?\" \"", "Mm-hm.\" \"", "Yeah?\" \"", "Word on the Net is he's a weapons dealer?\" \"", "OK, this is definitely something Eyes Only's gonna have to get into.\" \"", "Really?\" \"", "When?\" \"", "Tonight?\" \"", "No, I can't.\" \"", "I'll have to call you tomorrow.\" \"", "Yeah.\" \"", "Bye.\" \"", "Don't hold up the war on my account.\" \"", "The world will still be broken in the morning.\"" ]

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[ "Is it enough scintigraphy for everyone? ", "A cross-sectional analysis regarding the impact of justice in the distribution of health care resources.", "\nThe aim of this study was to evaluate the influence of three demographic criteria: gender, age and education level on the patients that perform a scintigraphy. ", "The cross-sectional study was applied to 220 patients to whom it was prescribed a scintigraphy by their treating physician. ", "Of these, 74 were men and 145 women, 10 children and 210 adults. ", "According to their education, 88 people did not graduate a high school, a total of 56 people graduated a high school, 27 persons graduated a college, 22 people had a university diploma and 26 people a PhD title. ", "The chi-square test was used to analyze the frequencies for the measurable variables on a nominal scale. ", "The significance threshold is considered to be 0.05, so, only the values which are smaller were taken into consideration. ", "We presented and analyzed only the data that fulfill this condition. ", "From our study it has been found that gender criterion played an important role in performing a scintigraphy for the first time. ", "71.6% of male patients were undergoing a scintigraphy for the first time. ", "The frequency of exploration by scintigraphy is increasing if you are a female patient than if you are a male patient: chi-square calculated value is chi2 (3)=12.398, p=0.006. ", "From our study it has been found that age item plays an important role in the scintigraphy investigations for all the patients. ", "The first scintigraphy was significantly performed in the 40-50 years old gap, whilst for the patients being aged over 60; they were probably not performing a first time scintigraphy. ", "We did not find significant statistical differences in respect of the education level. ", "So, we can conclude that access to that medical investigation is not depending on the socioeconomic status of the patient, but in some occasions, the number and the frequency distribution of performing a scintigraphy depend on gender and age. ", "We can also conclude that the principle of egalitarianism is fulfilled and so the justice principle in the distribution of health care resources must be reevaluated." ]

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[ "Interactive Forum: Advocacy at Stetson\n\nPlease join us for an online, interactive forum with Stetson Law Professor Roberta K. Flowers and current J.D. students. ", "This live interactive forum \"Advocacy at Stetson\" is aimed at helping prospective students learn more about Stetson Law's advocacy program, including coursework and opportunities to join our advocacy competition teams.", "\n\nDate: Thursday, April 6, 2017Time: 12:00-1:00 p.m. EST\n\nProfessor Flowers\n\nThe forum is now over, but you can still watch the video. ", "Please register to receive a link via email!", "\n\nUse form below to register in advance.", "\n\nTechnology Guidelines\n\nIn order to participate in this forum, please note our technology guidelines below. ", "We recommend that participants perform the following procedures:" ]

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[ "\n@h1 struct_constructors-02.flx\n@felix\n// struct with one element as function\nstruct S { x:int; y:int; z:int; }\nproc print (s:S) { print$ f\"struct S x=%d y=%d z=%d\" (s.x, s.y, s.z); }\nfun exec (p:(int * int * int) -> S, x:int, y:int, z:int) => p (x, y, z);\n\nval s1 = S (1, 2, 3); print s1; endl;\n\nval s2 = exec (S of (int * int * int), 4, 5, 6); print s2; endl;\n//val s3 = exec (S, 7, 8, 9); print s3; endl;\n\nval s4 = (S of (int * int * int)) (10, 11, 12); print s4; endl;\n//val s5 = (S) (13, 14, 15); print s5; endl;\n\nval f1 = S of (int * int * int); val s6 = f1 (16, 17, 18); print s6; endl;\n//val f2 = S; val s7 = f2 (19, 20, 21); print s7; endl;\n\nprint (exec (S of (int * int * int), 22, 23, 24)); endl;\n//print (exec (S, 25, 26, 27)); endl;\n\n@expect\nstruct S x=1 y=2 z=3\nstruct S x=4 y=5 z=6\nstruct S x=10 y=11 z=12\nstruct S x=16 y=17 z=18\nstruct S x=22 y=23 z=24\n@\n" ]

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[ "Be a USCA Sponsor\n\nSponsorship Levels - USCA offers several different basic sponsorship levels, each delivering a variety of benefits to sponsors. ", "USCA's sponsorship packages are designed to ensure that all participants in all athletic sectors come together to help build a stronger, better coaching industry that benefits everyone.", "\n\nOur Corporate Sponsorship team can design custom-made programs to help companies reach their financial, marketing, and philanthropic goals.", "\n\nMission Directed - Also, sponsors can specifically sponsor the cost of developing coaching-related articles, research, studies, white papers, video production, curriculum development, etc. ", "Through such “Mission-Directed” funds, sponsors can develop information they think is important, and use USCA’s platform as a means of disseminating it. ", "Other sponsorship funds are used by the national office to underwrite programs and operational costs, as needed." ]

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[ "Mental health integration: normalizing team care.", "\nThis article examines the impact of integrating mental health into primary health care. ", "Mental Health Integration (MHI) within Intermountain Healthcare has changed the culture of primary health care by standardizing a team-based care process that includes mental health as a normal part of the routine medical encounter. ", "Using a quantitative statistical analysis of qualitative reports (mixed methods study), the study reports on health outcomes associated with MHI for patients and staff. ", "Researchers interviewed 59 patients and 50 staff to evaluate the impact of MHI on depression care. ", "Patients receiving MHI reported an improved relationship with caregivers (P < .001) and improved overall functioning in their lives (P < .01). ", "Staff providing care in MHI reported that patients experienced improved access to mental health care, improved overall patient productivity in daily functions (P < .01), and access to team care (P < .001). ", "As MHI became routine, patients discussed complementary team interventions more frequently (P < .0001). ", "Mental health problems rank second in chronic disease today. ", "MHI offers promising results for improving the quality and cost of effective treatment for chronic disease. ", "This research provides guidelines for organizing mental health care, staff productivity, and patient satisfaction, using a team approach to improve outcomes." ]

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