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(1)H NMR

pH - sensitive polymer poly (polylactide-co-methacrylic acid)-b-poly (acrylic acid) was synthesized using atom transfer radical polymerization and ring-opening polymerization and characterized by gel permeation chromatography and (1)H NMR.

Based on the highly simple, accurate, non-targeted and non-destructively advantages of (1)H NMR, it could be used as a new screening tool of anti-inflammatory drugs in the metabolic profiling of GPLs.

(1)H NMR

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diabetes mellitus

Multivariate regression analysis showed that male patients with 41-50 years, PLA, diabetes mellitus, and hypertension were independent risk factors for HMKP infections.

6.7% newly developed diabetes mellitus after the procedure.

diabetes mellitus

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forelimb

The indications for the procedure were patients with: DVT who were to undergo surgery (n = 6), acute large free-floating iliofemoral DVT (deemed high-risk for long-term anticoagulation) (n = 7), new DVT during anticoagulation therapy (n = 6), DVT with gastrointestinal bleeding (n = 4), DVT with hematuria (n = 2), recent DVT (which extended during full dose anticoagulation treatment) while undergoing a long flight (n = 1) (temporary filter placement), DVT with arm hematoma (n = 1), DVT with unsteady gait and history of falls (n = 2), DVT with nose bleeding (n = 1), DVT with dementia and inability to receive anticoagulation treatment (n = 1), DVT and receiving chemotherapy and with thrombocytopenia (n = 1), and DVT and refusal to take anticoagulation medication (n = 1).

This indicates restricted joint mobility of the forelimb but primarily of the carpal joint.

arm

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fat body

Nine recreationally active male participants (mean± SD; age, 24±4; height, 177.3±9.9cm; body mass, 76.7±11.6kg; body fat, 14.7±5.8%).

These results suggest that the PLA2 gene may mediate humoral immune responses by reducing lipid storage in fat body cells in B. dorsalis.

body fat

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location

This anatomical location brings additional functional challenges (swallowing, phonation, respiration), especially in the pediatric population.

They are amenable to likelihood inference, and enable a wide variety of quantile regression models, with predictors for both the location and dispersion parameters.

anatomical location

abbreviations

APL

All-trans retinoic acid-induced inflammatory myositis in a patient with acute promyelocytic leukemia.

After 10 days of treatment, he developed acute renal failure that was completely reversible after complete remission of APL was achieved and therapy discontinued.

acute promyelocytic leukemia

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peripheral nerve toxicity

Among the patients with 1 year of follow-up, NVP therapy was significantly associated with developing rash and d4T therapy with developing peripheral neuropathy (p < 0.05).

These findings suggest that alpha-lipoic acid might reduce the risk of developing peripheral nerve toxicity in patients undergoing chemotherapy and encourage further confirmatory clinical trials.

peripheral neuropathy

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T cells

Furthermore, the cells at pH 6.6 were resistant to apoptosis by doxorubicin (P ≤ 0.05).

T cell responses to viruses are initiated and maintained in tissue sites; however, knowledge of human antiviral T cells is largely derived from blood.

cells

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insulin resistance

Possibly this combined with impaired fasting glucose, IR and dyslipidemia, could account for Cardio vascular risks in PCOS.

Obesity causes insulin resistance via a chronic low-grade inflammation.

IR

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North American

Extensive outbreaks of bark beetles have killed trees across millions of hectares of forests and woodlands in western North America.

This study represents the largest series of North American patients reviewed to date.

North America

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surfer's

The aims of this study were to describe the competition load of surfers during a single heat via objective and subjective methods and to analyze the relationship between objective and subjective methods with the judges' score.

The GPS was synchronized with a chronometer and a stationary video camera to identify the surfer's specific actions.

surfers

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model

(i) the Lee model (KO(Lee)) and

The results indicated that miR-26a was significantly downregulated in the heart tissue of the rat model, as well as in Ang II - induced CMs (P<0.05).

Lee model

abbreviations

CF

The results also indicated the lack of any relationship between objective and subjective measurements of cognitive functioning.

Conclusions There is low to moderate correlation between pulmonary and sinus pathogens in CF patients.

cognitive functioning

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HER2

To study the impact of hormone receptor (HR)- and human epidermal growth factor receptor 2 (HER2)-defined subtypes on survival of inflammatory breast cancer (IBC), and to determine whether sensitivity to neoadjuvant chemotherapy (NAC) varies with subtypes in a large IBC population.

Due to the implication of HER2 and angiogenesis -directed targeted therapies major advances in the treatment of gastric cancer could be reached.

HER2

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TS

We aimed to determine its lateralizing utility in patients with tuberous sclerosis complex (TSC).

A 40-year-old man with childhood-onset Tourette syndrome (TS) developed Huntington disease (HD).

TSC

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SF-36

The Physical Component of the SF-36 at 12 months was 42.6, which is comparable to values reported in previous studies for operative treatment of bicondylar plateau fractures.

SLE patients presenting neuropsychiatric symptoms showed a significantly reduced quality of life in all subscales of the SF-36.

SF-36

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CTA

This study used coronary computed tomography angiography (CCTA) as a mean to investigate whether increased EAT volume was associated with ISR.

A subset underwent invasive angiography to determine the diagnostic accuracy of CTA.

CCTA

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muscular dystrophy

We are still a long way from discovering an unequivocal pathogenetic interpretation of progressive muscular dystrophy in man.

Mild and severe muscular dystrophy associated with deletions in Xp21 of the human X chromosome.

muscular dystrophy

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blood-brain barrier

Annexin A1 (ANXA1), an anti-inflammatory messenger, is expressed in brain endothelial cells and regulates the BBB integrity.

We previously reported that in Alzheimer's disease patients, a high level of GM-CSF in the brain parenchyma downregulated expression of ZO-1, a blood-brain barrier tight junction protein, and facilitated the infiltration of peripheral monocytes across the blood-brain barrier.

BBB

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ApoE

Critically, these associations were present only among APOEɛ4 non-carriers.

We found that ApoE level is influence d by ApoE polymorphism in a gene - dependent manner.

APOEɛ4

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complete remission

Hematologic response was observed in 68% of patients (very good partial response or complete response in 29%), as well as improved survival.

In addition, the associations between different genotypes and short-term therapeutic efficacy [the complete remission (CR) rate], tumor metastasis and relapse, as well as the survival time following concurrent radiochemotherapy, were determined.

complete response

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statistical modeling

Despite the broad initial set of potential explanatory variables, only five predictors were jointly selected for the best statistical model.

A new HA reference is available for longitudinal growth assessment in achondroplasia, taking advantage of statistical modeling techniques and allowing for Z-score calculations.

statistical model

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coronary disease

Immunopathology of penicillamine-induced glomerular disease.

The hearts without coronary artery disease (average ejection fraction of this group 62% +/- 10%) had a VIP concentration of 14.1 +/- 7.9 pg/mg protein, and this was greater than in hearts of the patients with coronary disease and the hearts of patients receiving a transplant (P less than 0.05).

glomerular disease

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T-cell lymphomas

However, following splenectomy to increase the platelet count, biopsy of the mediastinal mass revealed T-cell large cell lymphoma.

Atm-null mice, as well as those null for p53, develop mainly T-cell lymphomas, supporting the view that these genes have similar roles in thymocyte development.

T-cell large cell lymphoma

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head injury

Head trauma was the most commonly associated injury in 275 patients with the highest rate in the ATV group (44%) who also had the highest rate of no helmet use (76%).

About 16.0% of AIS 4+ head injury involves the brainstem.

Head trauma

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ONS

Fourteen healthy volunteers were segregated into control and ONS groups.

In the ONS group, the serum d-ROMs level was significantly lower than in the control group (297 ± 43 and 327 ± 41 U.CARR, respectively, p = 0.018), while the serum BAP level was significantly higher than the control group (2410 ± 432 and 1979 ± 397 µmol/l, respectively, p = 0.005).

ONS

abbreviations

SD

The relationship of arthritis and sexual dysfunction was investigated among 169 patients with rheumatoid arthritis, osteoarthritis and spondyloarthropathy, 130 of whom were pair-matched to controls.

OBJECTIVE: To determine the safety and efficacy of adjunctive bupropion sustained-release (SR) on male sexual dysfunction (SD) induced by a selective serotonin reuptake inhibitor (SSRI), as SD is a common side-effect of SSRIs and the most effective treatments have yet to be determined.

sexual dysfunction

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group A

The two groups were homogenous in regard to all the base line variables.

Patients in group A were treated through a 1.5- to 2-cm longitudinal incision, and patients in group B were treated through the conventional flexor carpi radialis approach.

groups

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OA

Unrecognized dislocation with humeral head fracture affects joint function and humeral head vascularity and may lead to chronic instability, osteonecrosis, and osteoarthritis.

At age 31 a questionnaire-based screening for oligoamenorrhea (OA) and hirsutism (H): 2188 asymptomatic (controls), 331 OA, 323 H, 125 OA + H (PCOS).

osteoarthritis

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hypoxia

Heavy Resistance Training in Hypoxia Enhances 1RM Squat Performance

Conclusion: Heavy resistance training in hypoxia is more effective than placebo for improving absolute and relative strength.

Hypoxia

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PMD

In a more complex task commonly used to evaluate major akinetic symptoms of PD patients, 5 mg/kg AMN082 reverses the increased reaction time to respond to a cue of bilateral 6-OHDA-lesioned rats.

The cause of disease in this family remains unknown, but the association between this rare mutation and PMD is intriguing.

PD

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irregular heart beat

The total doses of ACC-9653 or phenytoin sodium necessary to convert the arrhythmia to a normal sinus rhythm were 24 +/- 6 and 14 +/- 3 mg/kg, respectively.

A group of doctors in Boston warn that the protease inhibitor Viracept may cause an irregular heart beat, known as bradycardia, in people with HIV.

arrhythmia

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literature reviews

Conjunctival tumor caused by Epstein-Barr virus -related infectious mononucleosis: Case report and review of literature

In 2011, based on literature reviews, it was recommended that the concentration of 0.02% aq.

review of literature

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memory formation

Whereas, the powder diet had no effect on memory function and BDNF mRNA level even at 16 weeks later.

Dynamic causal modeling results further demonstrate how the anterior STS interacts with the associative memory system to facilitate successful memory formation for AV face - name associations.

memory function

abbreviations

AD

Lethal cardiovascular complications, such as serious hypertension, myocardial infarction and aortic dissection, may occur because of uncontrolled catecholamine release.

It might better capture biological changes that are related to AD than cutoffs based on clinical diagnosis.

aortic dissection

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blood

Effect of organic and inorganic selenium supplementation on semen quality and blood enzymes in buffalo bulls

CMV genomes were detected predominantly in lung and also in spleen, BM, blood and LN.

blood

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methylated

In adjacent tissues 17 of 58 (29%) and 53 of 56 (96.5%) was methylated.

eFORGE determines the cell type - specific regulatory component of a set of EWAS -identified differentially methylated positions.

methylated

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IBS

METHODS: Thirty-eight patients with IBS (constipation-predominant, n = 17; diarrhoea-predominant, n = 21) underwent 24-h ambulatory jejunal manometry before and after 12 week's treatment [cisapride, 5 mg three times daily (n = 19) or placebo (n = 19)].

No significant differences in jejunal motility were found in the constipation-predominant IBS group.

IBS

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THL

Background The Chinese herbal mixture, Tien-Hsien liquid (THL), has been used as an anticancer dietary supplement for more than 20 years.

These results suggest that THL may be used as a complementary medicine for cancer patients previously treated with killed tumor cell vaccines, radiotherapy, or chemotherapy.

THL

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skin rash

It demonstrated that the expressions of 174 protein spots over 1045 quantified spots were altered after uranium exposure (p<0.05).

Thus, this child is a unique individual with inherited C3 deficiency presenting with absence of repeated infections, whose symptoms of fever, skin rash, and arthralgia were abated by whole blood transfusion.

spots

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Ceftazidime

Both the MIC50 (minimum inhibitory concentration) and the MIC90 of ceftazidim (0.5 μg/mL and 2 μg/mL, respectively) were higher than the MIC90 of all the other anti-pseudomonal beta-lactams (APBLs).

Ceftazidime (Cephalosporin) showed little efficacy against either culture.

ceftazidim

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renal dysfunction

Acute confusion induced by acetazolamide is a well known adverse drug reaction in patients with renal impairment.

On the contrary, among primary coronary artery bypass surgery patients, there were more acute myocardial infarctions and renal dysfunction in Group A (5.8% vs 2.0%, P = 0.027; 22.5% vs 15.2%, P = 0.036, respectively).

renal impairment

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liver transplant

Mediastinal mass diagnosed by endobronchial ultrasound as recurrent hepatocellular carcinoma in a post - liver transplantation patient

Abdomen closure in infant liver transplant with large-for-size grafts is a different area of discussion.

liver transplantation

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cerebral haemorrhages

These results suggest that PPA/caffeine can lead to cerebral hemorrhage in previously hypertensive animals when administered in greater than the allowed dosage.

CONCLUSIONS: Warfarin-induced cerebral haemorrhages are a major clinical problem with a high fatality rate.

cerebral hemorrhage

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Observational

Real-time observation of protein aggregates in pharmaceutical formulations using liquid cell electron microscopy

Observational, prospective cohort study.

observation

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EEG

To address this issue, we present a technique, namely the bispectral pairwise interacting source analysis (biPISA), for analyzing systems of cross-frequency interacting brain sources when multichannel electroencephalographic (EEG) or magnetoencephalographic (MEG) data are available.

The clinical history, EEG, and imaging results were retrieved.

EEG

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reperfusion therapy

In I/R group, rats were subjected to 45 minutes of renal pedicle occlusion followed by 24 hours of reperfusion.

In patients in the acute stage of stroke, an early FLAIR change is associated with the risk of HT following reperfusion therapy with a highly matched geographic relationship and common risk factors.

reperfusion

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reconstructive surgery

However, with judicious use of available measures it is possible to ensure the questions asked or tasks completed are relevant to the surgical reconstruction (s) undertaken.

The classification of failure of limb salvage after reconstructive surgery for bone tumors was adapted.

surgical reconstruction

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prevention

Among the 184 allo-HSCT recipients on levofloxacin prophylaxis, 28 (15.2 %) experienced breakthrough VSB.

Improving these health behaviors, and health factors included in the ICHI, could play an important role in CVD prevention.

prophylaxis

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AT

Primary mechanistic insight indicated that ALT could damage the bacterial cell membrane, leading to accumulation of antibiotics inside bacterial cells.

Fine genetic linkage mapping of the mouse AT region was performed using the interspecific backcross mice.

ALT

abbreviations

CAA

Here we present a novel approach for combined application of anti-enteroviral compounds, consisting of a consecutive alternating administration (CAA) course.

CAA was tested on 2 in vivo models of Coxsackievirus B3 infection in newborn mice at inoculation dose of 20 MLD50 (50% mouse lethal dose): neurotropic (Nancy strain) and cardiotropic (Woodruff strain) infections.

consecutive alternating administration

abbreviations

SA

Chitosan -functionalised poly(2-hydroxyethyl methacrylate) core-shell microgels as drug delivery carriers: salicylic acid loading and release

The study on drug loading, using salicylic acid (SA) as a model drug, was performed.

salicylic acid

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memory formation

These results suggest that the effect of molar loss and powder diet on memory function and BDNF mRNA levels were different, molar loss may have a greater long-term effect on memory ability than powder diet does.

Dynamic causal modeling results further demonstrate how the anterior STS interacts with the associative memory system to facilitate successful memory formation for AV face - name associations.

memory function

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preparation

The study included 428 patients with 56% receiving same - day laxative preparation and the remainder evening - before preparation.

It can also be used in patients who refuse the treatments which involve tooth reduction and preparation.

preparation

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Addison's disease

RESULTS: We observed positive associations of Parkinson's disease with ozone (odds ratio = 1.39; 95% CI: 0.98 to 1.98) and fine particulate matter (odds ratio = 1.34; 95% CI: 0.93 to 1.93) in North Carolina but not in Iowa.

X-linked adrenoleukodystrophy is a frequent cause of idiopathic Addison's disease in young adult male patients.

Parkinson's disease

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motif

PDs moved the lumbopelvic region earlier during left hip abduction than right hip abduction.

Using a combination of molecular - scale and real-time imaging, spectroscopy and spectrometry approaches, we introduce a structural motif with a universal insertion mode in reconstituted membranes and live bacteria.

region

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chronic diseases

Our findings show that access to better social capital (using measures of neighbourhood trust and community participation) is associated with a higher degree of physical mobility, independence, and mental well-being among older individuals but has no influence on chronic illnesses.

The SF-6D and both EQ-5D-5L value sets appeared to be valid but sensitive to different outcomes in Thai patients with chronic diseases.

chronic illnesses

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progression

The One4All testing intervention was more costly than SOC (CNY 2,182 vs. CNY 846), but facilitated earlier ART access, resulting in delayed disease progression and mortality.

Indeed, platelets within atheroma plaques have been shown to play a role in inflammation, in platelet - leucocyte aggregates and in thrombi formation and might thus be considered relevant biomarkers of atherosclerotic progression.

disease progression

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angiotensin-converting enzyme (ACE) inhibitors

The utilization of calcium channel blockers and angiotensin-converting enzyme inhibitors across the study period increased in all age categories.

BACKGROUND: Treatment with angiotensin-converting enzyme (ACE) inhibitors reduces mortality and morbidity in patients with chronic heart failure (CHF), but most affected patients are not receiving these agents or are being treated with doses lower than those found to be efficacious in trials, primarily because of concerns about the safety and tolerability of these agents, especially at the recommended doses.

angiotensin-converting enzyme inhibitors

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Neutrophil count

All patients were divided into four groups according to the audiometric curve and mean values of haematological parameters (haemoglobin, white blood cell, neutrophils and lymphocytes relative count, platelet count, haematocrit, prothrombin time, activated partial thromboplastin time, fibrinogen and neutrophil-to-lymphocite ratio) of each group were statistically compared.

Neutrophil count correlated with the molecular degree of perturbation, especially in TBDM patients.

neutrophils

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peripheral nerve toxicity

Optochiasmatic and peripheral neuropathy due to ethambutol overtreatment.

These findings suggest that alpha-lipoic acid might reduce the risk of developing peripheral nerve toxicity in patients undergoing chemotherapy and encourage further confirmatory clinical trials.

peripheral neuropathy

abbreviations

aerosol drugs

It is increasingly becoming accepted that inflammation may play an important role in the pathogenesis of Alzheimer's disease (AD), as several immune -related genes have been associated with AD.

This study demonstrated the possibility of personalized prediction of airway deposition of aerosol drugs by numerical simulations.

AD

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type 2 diabetic

Evidence links type 2 diabetes to dementia risk.

METHODS: In type 2 diabetic patients, cases who developed CAD were compared retrospectively with controls that did not.

type 2 diabetes

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mood disorder

Minor physical anomalies and dermatoglyphic signs in affective disorders: A systematic review

Cocaine-induced mood disorder: prevalence rates and psychiatric symptoms in an outpatient cocaine-dependent sample.

affective disorders

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PCNs

We randomized four primary care sites to training or wait-list conditions; PCPs at wait-list sites were trained after reassessment.

Under these circumstances, the accurate classification of PCNs becomes crucial.

PCPs

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ultrasonography

Antenatal consultation following limb malformation discovery using ultrasound scan

The study results showed that ultrasonography could be used to identify the type of intermediate tissue between the flexor pollicis longus tendon and the volar locking plate.

ultrasound scan

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polymer

Self-assembled polymeric vectors mixtures: characterization of the polymorphism and existence of synergistic effects in photodynamic therapy

The results also indicated that the type of polymer and ratio of drug to polymer affected size and desirable characteristics of the micelles.

polymeric

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AS

These data unambiguously establish specific noise-to-signal levels of head micro-movements as a biologically informed core feature of ASD.

We report on a family in which first cousins are affected by AS and PWS as a result of a familial paracentric inversion of 15q11-q13.

ASD

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polymers

A polynorbornene bearing pendant NTAs made by ring-opening metathesis polymerization was also synthesized to generate a polymeric COS / H2S donor.

Three oxides (ZrO2, Al2O3, SiO2), three metals (316LSS steel, Ti, Nb) and two polymers (corona treated polystyrene for cell culture and untreated polystyrene for bacteria culture), widely used for biomedical applications, were considered.

polymeric

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name

Current PN, increased serum levels of plant sterols stigmasterol, avenasterol, and sitosterol along with serum citrulline, a marker of enterocyte mass, predicted portal inflammation.

Audiovisual integration supports face - name associative memory formation

PN

abbreviations

RBC

Red blood cells (RBCs), the most abundant type of cells in our blood, have shown promises as a natural drug delivery system (DDS) with inherent biocompatibility.

The results show that the RBC transfer and deform without any lift force and rotation induced when it is located on the symmetry axis of the microchannel.

Red blood cells

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TC

However, phenol extraction produced a better 2DE map with greater resolution between spots, and TCA / acetone extraction produced higher protein yields.

Papillary TC was the most commonly diagnosed histological subtype, following the same incidence pattern as overall TC.

TCA

abbreviations

HPLC

A total 1204 samples from the tribals working in tea gardens of Assam were analysed for both Complete Blood Count (CBC) and High Pressure Liquid Chromatography (HPLC) for detection of haemoglobinopathies and β-thalassaemia.

The HPLC peaks were integrated and the concentrations in sample solutions were calculated.

High Pressure Liquid Chromatography

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breast-ovarian cancer

The single family with a BRCA2 mutation had the breast-ovarian cancer syndrome.

The set of 32 families in which no BRCA1 alterations were detected included 1 breast-ovarian cancer kindred manifesting clear linkage to the BRCA1 region and loss of the wild-type chromosome in associated tumors.

breast-ovarian cancer syndrome

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Horner's syndrome

Tourette syndrome in the context of evolution and behavioral ecology

Although rare, Horner's syndrome is a dreaded complication of surgery of the parapharyngeal space.

Tourette syndrome

abbreviations

kin discrimination

Serum ferritin levels were compared between patients with s-JIA and KD.

Selection for both strategies was constrained by direct costs and restricted kin discrimination.

KD

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Knockdown

Exosomes successfully delivered their cargo into inner retinal layers and the effects were reliant on miRNA, demonstrated by the diminished therapeutic effects of exosomes derived from BMSC after knockdown of Argonaute-2, a key miRNA effector molecule.

Knockdown of CXCL5 significantly suppressed U2OS cell migration and invasion.

knockdown

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E3 ubiquitin ligase

WDR26 promotes mitophagy of cardiomyocytes induced by hypoxia through Parkin translocation

Nevertheless, LIN-23 targeting CDC-25.2 for ubiquitination as a component of E3 ubiquitin ligase has not yet been tested.

Parkin

label_similarity

cholestasis

The liver damage was characterized according to hepatocellular, cholestatic, and mixed laboratory criteria and to histologic criteria when available.

Jaundice disappeared within 3 months but was followed by prolonged anicteric cholestasis marked by pruritus and high levels of alkaline phosphatase and gammaglutamyltransferase activities.

cholestatic

abbreviations

TC

The objective of this study was to determine if the use of fascia lata as a tendon regeneration guide (placed into the tendon canal following harvesting the semitendinosus tendon) would improve the incidence of tissue regeneration and prevent fatty degeneration of the semitendinosus muscle.

Diarrhea increased in TC group.

tendon canal

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cross-sectional study

Regression and repeated cross-sectional analyses was carried out, and defined daily dose was used to describe the utilization per thousand older people per day.

Habitual physical activity is associated with improved anthropometric and androgenic profile in PCOS: a cross-sectional study

cross-sectional analyses

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cancer

In mice phenozan reduced overall incidence and multiplicity of lung tumors (in females) and also overall multiplicity of all tumors (in females) and only malignant tumors (in males).

Participants ' continued smoking was explained by the stress of diagnosis; desire to maintain personal control; and lack of connection between smoking, cancer and health.

malignant tumors

abbreviations

FNDI

Identification of a novel nonsense mutation and a missense substitution in the vasopressin-neurophysin II gene in two Spanish kindreds with familial neurohypophyseal diabetes insipidus.

In this study, we analyzed two families with FNDI using direct automated fluorescent, solid phase, single-stranded DNA sequencing of PCR-amplified AVP-NPII DNA.

familial neurohypophyseal diabetes insipidus

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MSH

Moreover, the clinical blood flow and pulsation pressure similar to the human can be well simulated, which can be used to train the neurosurgical residents how to clip aneurysms more effectively.

A dystonia-like syndrome after neuropeptide (MSH/ACTH) stimulation of the rat locus ceruleus.

clip

synonyms

birth

This study demonstrates that microvascular vessel density in neonates born to mothers living at high altitude is higher than that in neonates born at sea level.

Anthropometric data were collected at birth, 3, 6, 12 and 24 months corrected age, and at 5 and 19 years.

born

label_similarity

C7 deficiency

The other six mutants investigated were all associated with enzyme deficiency.

We describe an aggressive and ultimately fatal case of PG in a patient with a congenital C7 deficiency.

enzyme deficiency

abbreviations

Nijmegen breakage syndrome

The rare diseases ataxia-telangiectasia (AT), caused by mutations in the ATM gene, and Nijmegen breakage syndrome (NBS), with mutations in the p95/nbs1 gene, share a variety of phenotypic abnormalities such as chromosomal instability, radiation sensitivity and defects in cell-cycle checkpoints in response to ionizing radiation.

The NBS1 protein is specifically mutated in patients with Nijmegen breakage syndrome and forms a complex with the DNA repair proteins Rad50 and Mrel1.

NBS

synonyms

deviation

Our results provide evidence that the clinical manifestations of infection with bat RABV variant occur at a later time when compared to what was observed with canine and marmoset rabies virus variants.

In the buccolingual direction, a deviation of 1.038mm was registered at the implant tip and 0.633mm at the implant shoulder.

variant

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investigation

This observational clinical evaluation study included 224 patients who were referred for MRCP.

This study aimed to expand the biological activities of Ts19 Frag-II through in vivo investigation.

clinical evaluation

term_identity

comparative studies

The comparative study between the Stoppa and LTE approaches for the bilateral inguinal hernia repair demonstrated that: (1) The LTE approach showed less surgical trauma despite the longer operation time; (2) Quality of life during the early post-operative period were similar; and (3) Complication rates were higher in the Stoppa group.

Although both co-substrates have been widely used, comparative studies are scarce.

comparative study

synonyms

Next-Generation Sequencing

We used targeted next generation sequencing (NGS), covering 24 candidate genes involved in neurodegenerative disorders, to analyze 40 probands with familial PD, and 10 patients with mixed neurodegenerative disorders.

Next-Generation Sequencing Approaches to Define the Role of the Autophagy Lysosomal Pathway in Human Disease: The Example of LysoPlex

next generation sequencing

synonyms

Peru

Several studies now demonstrate that it is possible to identify low-risk PE patients that can safely be treated as outpatients.

In this taxonomic treatment, O. annae becomes an endemic species to Peru and O. addae is endemic to Bolivia.

PE

term_identity

herbivores

Snowshoe hares (Lepus americanus) are an ecologically important herbivore because they modify vegetation through browsing and serve as a prey resource for multiple predators.

These data indicate that the greater GOX activity in generalist herbivores is not achieved by greater transcription rate, but by greater transcript stability, greater translation rate, better enzyme stability and/or their combination.

herbivore

label_similarity

nephritis

VA creation and maintenance pathways functioned best when nephrologists, surgeons and radiologists were co-located on the same campus with close multi-disciplinary working, protected clinical time, and proactive VA maintenance.

Complement deficiency and nephritis.

nephrologists

label_similarity

cells

Finally, we can recommend acacetin as a promising compound for further drug development assays for the CLL treatment.

This was mirrored by lower expression levels of Nestin and the mitotic marker phospho-histone H3 in vivo in the P9 hippocampus, as well as a decreased proportion of cells in the G2/M phases of the P7 DG.

CLL

label_similarity

MFL regimen

To explore a more effective treatment for newly diagnosed, advanced-stage extranodal natural killer/T-cell lymphoma, nasal type (ENKTL), we conducted a phase 4 study of the cisplatin, dexamethasone, gemcitabine, pegaspargase (DDGP) regimen.

The MFL regimen achieves little palliative benefit and induces severe toxicity at a fairly high rate.

regimen

label_similarity

bp

To determine current treatment options of chronic low back pain (LBP) as defined by randomized controlled trials (RCTs) and to compare effectiveness of those treatments using a mixed-treatment comparison (MTC).

The relative frequency and density were 398.92 loci/Mb and 7500.62 bp /Mb, respectively.

LBP

abbreviations

SD

The effects of the adjunctive bupropion on male sexual dysfunction induced by a selective serotonin reuptake inhibitor: a double-blind placebo-controlled and randomized study.

OBJECTIVE: To determine the safety and efficacy of adjunctive bupropion sustained-release (SR) on male sexual dysfunction (SD) induced by a selective serotonin reuptake inhibitor (SSRI), as SD is a common side-effect of SSRIs and the most effective treatments have yet to be determined.

sexual dysfunction

label_similarity

peripheral nerve toxicity

Peripheral neuropathy due to nutritional deficiency of thiamine and riboflavin was common (10.1%) and presented mainly as sensory and sensori-motor neuropathy.

These findings suggest that alpha-lipoic acid might reduce the risk of developing peripheral nerve toxicity in patients undergoing chemotherapy and encourage further confirmatory clinical trials.

Peripheral neuropathy

term_identity

EC

There is considerable debate about the benefits and risks of electronic cigarettes (ECs).

H2S acts differentially on EC migration and tubulogenesis.

ECs