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SECONDARY OBJECTIVES: The use of Rescue medication, proportion of patients who required hospitalization, worsening of heart failure or pulmonary oedema, side effect of medication ( dizziness, headaches, gastrointestinal symptoms) |
PATEINT POPULATION: Adults (18 and older) presenting to the emergency department at Sultan Qaboos University Hospital with symptomatic atrial fibrillation or atrial flutter with rapid ventricular response requiring treatment. |
INTERVENTION: A single oral dose of 5 mg Bisoprolol (maximum dose of 5 mg) or a single intravenous dose of Diltiazem at 0.25 mg/kg (to a maximum dose of 30 mg). |
CLINICAL MEASURMENT: Heart rate recorded every 15 minutes up to the 90-minute mark, with a 12-lead ECG performed every 30 minutes. |
OUTCOME: For therapy to be considered effective, patients must achieve a ventricular rate ≤110/min or experience a drop-in ventricular rate of at least 20% at 60 minutes. conditions: Atrial Fibrillation With Rapid Ventricular Response conditions: Atrial Flutter With Rapid Ventricular Response studyType: INTERVENTIONAL ... |
* Participants: Patients with atrial fibrillation/flutter and rapid ventricular rate. |
* Treatment Arms: Oral Bisoprolol vs. Intravenous Diltiazem. |
* Randomization: Subjects randomly assigned to either treatment group. |
* Primary Endpoint: Reduction of heart rate to a target level within a specific timeframe. |
* Secondary Outcomes: Adverse effects, hospital admission rates, additional rate control needs. |
* Objective: Compare effectiveness and safety of oral Bisoprolol to intravenous Diltiazem. |
* Monitoring: Continuous observation of vital signs and electrocardiograms for safety. primaryPurpose: TREATMENT masking: DOUBLE maskingDescription: While the treating physician, nurse, and the patient will not be blinded to the treatment, the investigator collecting data and the statistician analysing it will remain b... |
<|newrecord|> nctId: NCT06276114 id: 07 briefTitle: IVL vs ELCA for Stent Underexpantsion (IVL-ELCA DRAGON) acronym: DRAGON overallStatus: COMPLETED date: 2020-08-01 date: 2023-10-31 date: 2023-10-31 date: 2024-02-23 date: 2024-02-23 name: Medical University of Silesia class: OTHER briefSummary: The IVL- ELCA DRAGON Re... |
The primary efficacy endpoint was device success (technical success with a final stent expansion ≥ 80%). Thirty days device-oriented composite endpoint (DOCE: cardiac death, target lesion revascularization, or target vessel myocardial infarction) was the secondary endpoint. conditions: Coronary Artery Calcification con... |
<|newrecord|> nctId: NCT06276101 id: NEWISH-HPV-101 briefTitle: NWRD08 DNA Plasmid for HPV-16 and/or HPV-18 Related Cervical HSIL overallStatus: RECRUITING date: 2024-01-25 date: 2024-12-30 date: 2025-07-30 date: 2024-02-23 date: 2024-02-23 name: Newish Technology (Beijing) Co., Ltd. class: INDUSTRY briefSummary: This ... |
<|newrecord|> nctId: NCT06276088 id: NFEC-2024-067 briefTitle: Plasma and Tissue SAA1 Levels in Cancer Patients to Predict Hyperprogression of Immunotherapy overallStatus: RECRUITING date: 2024-02-18 date: 2025-12-31 date: 2026-10-31 date: 2024-02-23 date: 2024-03-15 name: Nanfang Hospital, Southern Medical University ... |
<|newrecord|> nctId: NCT06276075 id: 10/KRN/2020 briefTitle: The Impact of Erigo®Pro Therapy and Motor Imagery on the Balance of Stroke Patients. overallStatus: COMPLETED date: 2022-12-15 date: 2023-05-10 date: 2023-09-10 date: 2024-02-23 date: 2024-02-23 name: Anna Olczak class: OTHER briefSummary: The aim of the stud... |
<|newrecord|> nctId: NCT06276062 id: Titanium nail usage briefTitle: Uses of Titanium Nail in Pediatric Fractures overallStatus: RECRUITING date: 2023-09-01 date: 2024-09 date: 2024-10 date: 2024-02-23 date: 2024-02-28 name: Sohag University class: OTHER briefSummary: The aim of this study is to investigate the short t... |
<|newrecord|> nctId: NCT06276049 id: DGETRRP2023-54 briefTitle: ChatGPT Helping Advance Training for Medical Students: A Study on Self-Directed Learning Enhancement acronym: CHAT-MS overallStatus: ACTIVE_NOT_RECRUITING date: 2023-11-25 date: 2024-01-06 date: 2024-03-02 date: 2024-02-23 date: 2024-02-23 name: Wang Shalo... |
How does LearnGuide influence SDL skills among medical students? Can LearnGuide improve critical thinking and learning flow as measured by Cornell Critical Thinking Test (CCTT) Level Z score and Global Flow Score (GFS)? |
Participants will: |
Undergo a two-hour introduction to LearnGuide. Engage in 12 weeks of SDL task-based training with LearnGuide\&#39;s support. |
If there is a comparison group: Researchers will compare the group utilizing LearnGuide for SDL and the group without this tool to see if there is a significant difference in SDL skills, critical thinking, and learning flow experiences. conditions: Self-Directed Learning conditions: Artificial Intelligence conditions: ... |
<|newrecord|> nctId: NCT06276036 id: CAPID briefTitle: Autoimmune Cytopenias as a Sign of Primary Immunodeficiency. overallStatus: ACTIVE_NOT_RECRUITING date: 2019-07-23 date: 2024-12-01 date: 2025-06-01 date: 2024-02-23 date: 2024-03-29 name: Meyer Children's Hospital IRCCS class: OTHER briefSummary: Autoimmune cytope... |
<|newrecord|> nctId: NCT06276023 id: 2023P003638 id: 1R01AG078204-01 type: NIH link: https://reporter.nih.gov/quickSearch/1R01AG078204-01 briefTitle: Supporting Our Caregivers In ADRD Learning (SOCIAL) acronym: SOCIAL overallStatus: RECRUITING date: 2024-03-22 date: 2025-03-15 date: 2025-04-01 date: 2024-02-23 date: 20... |
The main aim is to: Demonstrate feasibility, acceptability, credibility, fidelity, preliminary efficacy and evidence for proposed mechanism of MASC through a pilot randomized controlled trial. |
Relevant stakeholders (caregivers of persons with ADRD) will participate in the intervention. conditions: Alzheimer's Disease and Related Dementias conditions: Quality of Life conditions: Caregiver Stress studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: SINGLE_GROUP interventionModelDescri... |
<|newrecord|> nctId: NCT06276010 id: 2023-102 briefTitle: Use of Nafamostat Mesilate for Anticoagulation in Patients With ECMO overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2026-03-01 date: 2026-12-31 date: 2024-02-23 date: 2024-02-26 name: Xiaotong Hou class: OTHER briefSummary: The purpose of this study is... |
<|newrecord|> nctId: NCT06275997 id: GAIN briefTitle: GAIN Project: Gastric Cancer and Artificial Intelligence acronym: GAIN overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2026-03 date: 2028-03 date: 2024-02-23 date: 2024-02-23 name: Istituto Clinico Humanitas class: OTHER briefSummary: Our GAIN project comprise... |
The nation-level multi-center tandem randomized controlled trial (WP1) will contribute to a better understanding of how the real-time AI algorithm can reduce miss rate of early gastric cancer and dysplasia during gastroscopy. Moreover, the innovation project will contribute to development of a novel AI tool (WP2) that ... |
<|newrecord|> nctId: NCT06275984 id: PI23/00288 id: 4R23/440 type: OTHER domain: IDIAP Jordi Gol briefTitle: Effectiveness of Online Training in Cardiopulmonary Resuscitation Maneuvers for a Network of Volunteers. acronym: EFORCP overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2025-12 date: 2026-12 date: 2024-02-... |
Hypotheses: Online education in CPR maneuvers is an effective and efficient tool for training individuals from the general population on how to respond to cardiac arrests |
Objectives: The primary aim of this study is to assess the efficacy of online CPR and AED training within the general population of the province of Tarragona. Specific objectives include: 1) evaluating participants' theoretical and practical CPR skills in the short and medium term following online training, and 2) expl... |
Methodology:This study will unfold in several phases: 1) Online CPR-AED training and assessment of theoretical knowledge acquisition; 2) Evaluation of acquired practical CPR skills (know-how) within a simulation environment, conducted on a subset of the population completing phase 1;3)Analysis of the experiences of a s... |
Variables and determinations:The primary response variable for phase 1 will be the difference in scores obtained from the online questionnaire between the final (post-training) and initial (pre-training) assessments. |
In phase 2, the main variable will be the pass/fail categorization of scores in the simulation. This evaluation will be conducted by two members of the Advanced Clinical Simulation Unit at Joan XXII Hospital using a predefined checklist. Throughout the various phases of the study, socio-demographic data and course perf... |
Expected results: The research team for this study aims to ascertain the efficacy and effectiveness of online CPR-AED training within the general population. Furthermore, the study aims to provide evidence regarding the optimal duration and frequency for repeating such training. |
Applicability and Relevance: This proposal advocates for a significant and innovative project, given the dearth of literature on this topic. While there are existing indications and studies on CPR-AED training among specific populations such as students and healthcare professionals, the presented proposal seeks to broa... |
<|newrecord|> nctId: NCT06275971 id: KBSMC 2022-07-006 briefTitle: Effectiveness of Continuous Glucose Monitoring System Among Cardiac Surgery Patients overallStatus: RECRUITING date: 2022-11-24 date: 2024-06-30 date: 2024-08-31 date: 2024-02-23 date: 2024-02-23 name: Kangbuk Samsung Hospital class: OTHER name: DexCom,... |
<|newrecord|> nctId: NCT06275958 id: 2023-506115-17 id: 2023-506115-17 type: EUDRACT_NUMBER briefTitle: DOSAGE Study: Upfront Dose-Reduced Chemotherapy in Older Patients With Metastatic Colorectal Cancer acronym: DOSAGE overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2028-06 date: 2028-12 date: 2024-02-23 date: 2... |
Primary outcome is PFS. Secondary endpoints include grade ≥3 toxicity, QoL, physical functioning, overall survival, number of treatment cycles, dose reductions, hospital admissions, cumulative received dosage and cost-effectiveness. conditions: Older Patients conditions: Colorectal Cancer conditions: Metastatic Cancer ... |
<|newrecord|> nctId: NCT06275945 id: 1010073 briefTitle: Feasibility Study of A VoRo UrologIc ScaffolD (ARID) acronym: ARID overallStatus: RECRUITING date: 2023-04-03 date: 2026-07-30 date: 2026-10-30 date: 2024-02-23 date: 2024-02-23 name: Levee Medical, Inc. class: INDUSTRY name: RQMplus briefSummary: The objective o... |
The study is a prospective, multicenter, single arm study. Up to 40 subjects will be treated at up to 3 investigational sites in Panama. Subjects will be followed up post-treatment at catheter removal, 6 weeks post prostatectomy, 3 months, 6 months, 12 months and 2 years. conditions: Stress Urinary Incontinence conditi... |
<|newrecord|> nctId: NCT06275932 id: TermoNeo/2023 briefTitle: Management of Healthy Newborn's Body Temperature at Birth overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-04-01 date: 2025-05-31 date: 2024-02-23 date: 2024-02-23 name: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico class: OTHER br... |
Hypothermia at birth could cause risks or comorbidities such as an increased risk of infant mortality, hypoglycemia, sepsis, metabolic acidosis, respiratory distress syndrome (RDS) and intraventricular hemorrhage (IVH). |
One of the factors that affects heat loss in the delivery room is the relationship between surface area, volume and body mass of the newborn. The decrease in body temperature is directly related to gestational age and weight at birth; indeed, this problem is much more present in premature and/or low weight newborns at ... |
To date, the strategies that are implemented for the physiological newborn are documented in the literature are, in addition to the heat chain described by the World Health Organization (WHO), the implementation of skin-to-skin contact (skin to skin) mother-newborn. |
Some studies demonstrating the beneficial effect of this procedure on maintenance of the newborn's body temperature. |
The aim of this study is to evaluate two healthcare interventions to prevent heat loss of healthy newborns at birth. conditions: Newborn, Infant conditions: Body Temperature conditions: Delivery Room studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION maski... |
<|newrecord|> nctId: NCT06275919 id: IOV-BT-1-2023 MIRAGE briefTitle: Regorafenib for Recurrent Grade 2 and 3 Meningioma (MIRAGE Trial) acronym: MIRAGE overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2026-12 date: 2027-03 date: 2024-02-23 date: 2024-03-15 name: Istituto Oncologico Veneto IRCCS class: OTHER name: ... |
Small trials and case series suggest clinical relevant activity of several VEGF inhibitors such as sunitinib, bevacizumab and valatinib reporting a 6m-PFS rate of 42-64%. Indeed, VEGF and VEGF receptors (VEGFR) are regularly overexpressed in meningiomas and can correlate with outcome. |
Regorafenib inhibits angiogenic receptor tyrosine kinases (RTKs) and is highly selective for VEGFR1/2/3; moreover Regorafenib inhibits PDGFRB, FGFR1 and oncogenic intracellular signalling cascades involving c-RAF/RAF1 and BRAF highly expressed in meningiomas. |
Noteworthy, Regorafenib showed antitumor activity in vitro and in vivo in a recent study; indeed, Regorafenib showed significant inhibition of meningioma cell motility and invasion and in vivo, mice with orthotopic meningioma xenografts showed a reduced volume of signal enhancement in MRI following Regorafenib therapy;... |
Moreover, Regorafenib showed good efficacy in different cancer types, such as colorectal cancer, GIST, hepatocellular carcinoma and glioblastoma (REGOMA trial) , maintainingmaintaining a good quality of life. conditions: Meningioma, Malignant studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionM... |
<|newrecord|> nctId: NCT06275906 id: NAFLD-POS5 briefTitle: Influence of a Mediterranean Diet Combined With a Physical Activity Intervention, on NAFLD and Inflammation Parameters. acronym: NAFLD-POS5 overallStatus: NOT_YET_RECRUITING date: 2024-04-08 date: 2025-04-08 date: 2026-04-08 date: 2024-02-23 date: 2024-02-23 n... |
The aim of the study is to evaluate whether the adoption of two different models of Mediterranean Diet, based on the different percentage of carbohydrates and lipids, associated with a program of moderate intensity aerobic physical exercise, in patients with obesity and NAFLD can exercise, after only 3 months, effects ... |
* specific aspects associated with NAFLD, such as the degree of hepatic steatosis and fibrosis; |
* circulating levels of molecules correlated with the degree of generalized and hepatic inflammation and the blood concentrations of metabolic and cardiovascular risk factors associated with abdominal obesity; |
* intestinal barrier; |
* body composition; |
* intestinal microbiota; |
* symptoms of IBS (irritable bowel syndrome) in patients with NAFLD. conditions: NAFLD conditions: Obesity conditions: IBS studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The study evaluates the effects of two different Mediterranean Diet models, bas... |
The Mediterranean Diet is associated with a program of moderate intensity aerobic physical exercise (walking) carried out 3 times a week for 3 months. primaryPurpose: TREATMENT masking: NONE count: 60 type: ESTIMATED name: Mediterranean diet and moderate intensity physical exercise (outdoor walking). measure: The effec... |
<|newrecord|> nctId: NCT06275893 id: ACM01 briefTitle: IC14 (Atibuclimab) in Arrhythmogenic Cardiomyopathy overallStatus: RECRUITING date: 2024-03-29 date: 2025-02-01 date: 2025-08-01 date: 2024-02-23 date: 2024-04-02 name: Implicit Bioscience class: INDUSTRY briefSummary: The goal of this clinical trial is to test IC1... |
Participants will be asked to undergo screening and baseline testing, then receive 4 intravenous infusions with blood measurements before and after the infusion (including 24, 48, and 72 hours and 7, 14, and 28 days). Participants will be offered specialized scanning of the heart muscle, and will be asked to provide re... |
<|newrecord|> nctId: NCT06275880 id: F-2023-3201-066 briefTitle: Intraarticular Collagen in Patients With Gonarthrosis overallStatus: COMPLETED date: 2023-04-01 date: 2023-07-30 date: 2024-01-10 date: 2024-02-23 date: 2024-02-23 name: Instituto Mexicano del Seguro Social class: OTHER_GOV briefSummary: The objective of ... |
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