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The absorption of BAY2927088 into the blood is dependent on the amount of acid present in the stomach. Esomeprazole is a medicine which is used in the treatment of heartburn and excessive acid in the stomach. Both food and esomeprazole may change the amount of acid present in the stomach. |
The main purpose of this study is to find out how food and esomeprazole may affect the absorption of BAY2927088 into the blood of healthy participants. For this, researchers will measure the levels of BAY2927088 in participants' blood when it is given with or without food as well as with or without esomeprazole. Resear... |
* Area under the curve (AUC): a measure of the total amount of BAY2927088 in participants' blood over time |
* Maximum observed concentration (Cmax): the highest amount of BAY2927088 in participants' blood |
The study will have 4 treatment periods: |
- Periods 1 to 3 (Day 1 to Day 9): All participants will take BAY2927088 with a low-fat meal, with a high-fat meal, and on an empty stomach, but in a different order, over the 3 study periods. Each period will last for 3 days and BAY2927088 will be given on the first day of each period. |
On Day 9, participants will take esomeprazole on an empty stomach. |
- Period 4 (Day 10 to Day 14): On Days 10 and 11, participants will take esomeprazole on an empty stomach. On Day 12, participants will take esomeprazole on an empty stomach. After 1 and a half hours, participants will take low-fat meal and BAY2927088. |
On Day 13, participants will take esomeprazole on an empty stomach. |
Participants will be in this study for about 8 weeks with 3 visits to the study clinic. |
Participants will visit the study clinic: |
* at least once, 2 to 28 days before the treatment starts, to confirm they can take part in this study |
* once on the day before the treatment starts and will stay in the clinic until Day 14 of the treatment |
* once, 7 to 10 days after last dose of BAY2927088, for a health check-up |
During the study, the doctors and their study team will: |
* do physical examinations |
* collect blood samples from the participants to measure the levels of BAY2927088 |
* check participants' health by performing tests, such as blood and urine tests, and checking heart health using an electrocardiogram (ECG) |
* ask the participants questions about how they are feeling and what adverse events they are having An adverse event is any medical problem that a participant has during a study. The study doctors keep track of all adverse events, irrespective of whether they think it is related or not to the study treatment. condition... |
<|newrecord|> nctId: NCT06378645 id: 2023-01682 briefTitle: Effect of Propofol vs. Sevoflurane on Erections During Narcosis In Transurethral Surgery acronym: PENIS overallStatus: RECRUITING date: 2024-02-01 date: 2026-12-01 date: 2026-12-01 date: 2024-04-22 date: 2024-04-22 name: Etienne Xavier Keller class: OTHER brie... |
To reduce greenhouse gas emissions, the primary use of propofol instead of gaseous agents is being recommended for general anesthesia. Whether propofol may be associated with an increased or decreased rate of unwanted intraoperative penile erection compared to other anesthetic agents is not known. More generally, there... |
This study aims to determine whether general anesthesia with propofol is more likely to cause intraoperative erections compared to sevoflurane during transurethral operations. conditions: Erection; Incomplete studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PRE... |
<|newrecord|> nctId: NCT06378632 id: CLN0011 DETECT-HF briefTitle: AN INTERNATIONAL, OBSERVATIONAL, BLINDED STUDY TO ASSESS THE PERFORMANCE OF THE CORDIO HEARO SYSTEM acronym: DETECT-HF overallStatus: RECRUITING date: 2022-02-11 date: 2024-07-15 date: 2024-12-01 date: 2024-04-22 date: 2024-04-22 name: Cordio Medical cl... |
This is an international, multicenter, observational, non-interventional, prospective, blinded, single-arm, two-period study, to collect patient utterances that will be retrospectively analyzed to determine the sensitivity and UPNR of the HearO system. conditions: Heart Failure studyType: OBSERVATIONAL observationalMod... |
<|newrecord|> nctId: NCT06378619 id: CSAPG-50 briefTitle: Tapping Test and the Archimedean Spiral for the Differential Diagnosis of Tremor. Machine Learning Approach acronym: MATSEP overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-06 date: 2025-06 date: 2024-04-22 date: 2024-04-22 name: Consorci Sanitari de l... |
<|newrecord|> nctId: NCT06378606 id: P.T.REC/012/004907 briefTitle: Effect of Technology on Cognitive Function in Elderly acronym: cogntion overallStatus: RECRUITING date: 2023-07-01 date: 2024-06-01 date: 2024-06-01 date: 2024-04-22 date: 2024-04-22 name: Nourhan Hesham Ali class: OTHER name: Cairo University briefSum... |
<|newrecord|> nctId: NCT06378593 id: 3HP-2827-102 briefTitle: A Study of 3HP-2827 in Treatment of Unresectable or Metastatic Solid Tumors With FGFR2 Alterations overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2028-03 date: 2028-06 date: 2024-04-22 date: 2024-04-22 name: 3H (Suzhou) Pharmaceuticals Co., Ltd. class... |
<|newrecord|> nctId: NCT06378580 id: LGF22H160084 id: LGF22H160084 type: OTHER_GRANT domain: Zhejiang Provincial Basic Public Welfare Research Program briefTitle: The Prognostic Impact of Surufatinib for the Treatment of Advanced Pancreatic Ductal Adenocarcinoma overallStatus: COMPLETED date: 2022-07-01 date: 2023-07-0... |
A retrospective analysis of patients with PDAC who underwent surufatinib at Zhejiang Cancer Hospital (Hangzhou,China) from July 2022 to July 2023.The database was extracted from the preoperative demographics, blood markers, and surgical pathology information of patients undergoing surufatinib in the investigators' hosp... |
<|newrecord|> nctId: NCT06378567 id: HCD J8923 briefTitle: A Study to Assess the Effects of Dietary Supplement Drinks on Sleep, Stress and Mood overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-05 date: 2024-05 date: 2024-04-22 date: 2024-04-22 name: The Water Street Collective class: INDUSTRY name: British Am... |
<|newrecord|> nctId: NCT06378554 id: IRB00111227 briefTitle: Cereset Research for Performance Improvement in a Hospital Nursing Unit overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-05 date: 2026-05 date: 2024-04-22 date: 2024-04-22 name: Wake Forest University Health Sciences class: OTHER name: Susanne Marcu... |
<|newrecord|> nctId: NCT06378541 id: SDR 21-267 briefTitle: Smartphone App Enhanced Facilitation Among Veterans in a Mental Health Inpatient Setting (Project HOPE) acronym: Project HOPE overallStatus: NOT_YET_RECRUITING date: 2024-11-01 date: 2028-10-31 date: 2028-10-31 date: 2024-04-22 date: 2024-04-22 name: VA Office... |
<|newrecord|> nctId: NCT06378528 id: 2023-1706 id: Protocol Version Jan 2024 type: OTHER domain: UW Madison id: A538900 type: OTHER domain: UW Madison briefTitle: Ketamine-assisted Psychotherapy for Adolescent PTSD (KAP) overallStatus: NOT_YET_RECRUITING date: 2024-08 date: 2025-08 date: 2025-08 date: 2024-04-22 date: ... |
<|newrecord|> nctId: NCT06378515 id: Glymphactive briefTitle: Physical Activity, Sleep and Brain Health Based on the Glymphatic System overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-04 date: 2025-12 date: 2024-04-22 date: 2024-04-22 name: University of Valencia class: OTHER name: University of Oulu briefSum... |
<|newrecord|> nctId: NCT06378502 id: antibiotic-resistence briefTitle: The Effect of Different Antibiotic Protocols on Peri-implant Tissue Health overallStatus: NOT_YET_RECRUITING date: 2024-05-03 date: 2025-12-30 date: 2026-06-30 date: 2024-04-22 date: 2024-04-22 name: Universita degli Studi di Genova class: OTHER bri... |
<|newrecord|> nctId: NCT06378489 id: 2022-0346-01 briefTitle: The Use of Etonogestrel Contraceptive Implant as Treatment for Endometrial Hyperplasia Without Atypia: A Cohort Study overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2025-01-31 date: 2025-05-31 date: 2024-04-22 date: 2024-04-22 name: University of t... |
The etonogestrel implant (Implant NXT) has been approved for contraceptive use by the US FDA in 2006. The mchanism of action of the implant for contraception suggests a potential application for its use in the treatment on hyperplasia. Off-label use of the implant for adrnomyosis, endometriosis and chronic pelvic pain ... |
<|newrecord|> nctId: NCT06378476 id: 855188 briefTitle: Supportive Understanding and Patient-centered Partnership for Optimizing Renal Treatment acronym: SUPPORT overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2025-06 date: 2025-09 date: 2024-04-22 date: 2024-04-24 name: University of Pennsylvania class: OTHER br... |
<|newrecord|> nctId: NCT06378463 id: PSY-2324-S-0362 briefTitle: Cognitive Remediation and Transcranial Direct Current Stimulation in Severe Mental Illness (SMI) acronym: HEADDSET+ overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2027-04 date: 2027-04 date: 2024-04-22 date: 2024-04-22 name: University of Gronin... |
<|newrecord|> nctId: NCT06378450 id: 2022-23892-31512-2 briefTitle: Dose-Response Effects of Mindfulness Meditation overallStatus: NOT_YET_RECRUITING date: 2024-04-22 date: 2024-11-30 date: 2024-11-30 date: 2024-04-22 date: 2024-04-24 name: University of Melbourne class: OTHER briefSummary: The goal of this randomized ... |
The main question it aims to answer is whether larger doses of mindfulness meditation yield greater positive changes in wellbeing than smaller doses. |
Our hypotheses are that (1) larger doses of mindfulness training will yield significantly larger effects, and (2) different doses will be significantly associated with variation in participant engagement, with lower engagement associated with higher doses. |
Researchers will compare each of three dose conditions, 10-min, 20-min, 30-min, against a minimal dose condition of 3-4 min. |
Participants will take a 28-day mindfulness meditation course, with guided audio instructions provided daily throughout the intervention period (excluding one rest day per week). They will also be asked to respond to surveys before, during, and after the intervention. conditions: Well-Being, Psychological conditions: D... |
<|newrecord|> nctId: NCT06378437 id: GLB-001-02 briefTitle: A Study of GLB-001 in Patients With Myeloid Malignancies overallStatus: NOT_YET_RECRUITING date: 2024-04-22 date: 2026-12-31 date: 2027-12-31 date: 2024-04-22 date: 2024-04-22 name: Hangzhou GluBio Pharmaceutical Co., Ltd. class: INDUSTRY briefSummary: Study G... |
<|newrecord|> nctId: NCT06378424 id: 2023-6/6 briefTitle: The Effectiveness of Local Dry Cold, Hot and Vibration Applications in Peripheral Intravenous Catheterization overallStatus: COMPLETED date: 2023-03-22 date: 2023-03-22 date: 2023-08-23 date: 2024-04-22 date: 2024-04-22 name: Uludag University class: OTHER brief... |
Methods: The study included 120 adults who were randomly selected between March and August 2023. One application group (n=30) received local hot application, one group (n=30) received local cold application, and one (n=30) received local vibration using the Buzzy® device. The applications, to the site of the peripheral... |
<|newrecord|> nctId: NCT06378411 id: P109 briefTitle: Development and Application of a Musical Game for Motor Rehabilitation overallStatus: RECRUITING date: 2024-04-04 date: 2024-07 date: 2024-10 date: 2024-04-22 date: 2024-04-22 name: Universidade da Madeira class: OTHER briefSummary: The aim of this study is to devel... |
<|newrecord|> nctId: NCT06378398 id: UMCC 2023.037 id: HUM00247729 type: OTHER domain: University of Michigan id: UMI23-13-01 type: OTHER domain: DCP Protocol Number id: 1UG1CA242632-01A1 type: NIH link: https://reporter.nih.gov/quickSearch/1UG1CA242632-01A1 briefTitle: A Trial of Omeprazole and Low Dose Aspirin to Ide... |
The study does involve biopsies of the colorectal tissue before and after taking the study medications. The biopsies are samples of tissue, about the size of a grain of rice, that will be taken from the colon or rectum before and after taking the study medications. This is done during a usual, clinical colonoscopy exam... |
<|newrecord|> nctId: NCT06378385 id: DevelopmentCEOAS briefTitle: Development and Content Validation of the Childhood Early Oral Aging Syndrome (CEOAS) Index for the Deciduous Dentition overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2024-10-31 date: 2024-12-20 date: 2024-04-22 date: 2024-04-25 name: Universit... |
<|newrecord|> nctId: NCT06378372 id: ETICA-ULE-064-2023 briefTitle: How Does Pianistic Musical Training Influence the Development of Alzheimer's Disease? overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2024-08-01 date: 2025-06-01 date: 2024-04-22 date: 2024-04-22 name: David Franco Castellanos class: OTHER nam... |
The key question is: Can pianistic practice influence the development of Alzheimer's disease? |
Participants will receive piano lessons for 4 weeks (20 sessions) and we will evaluate the evolution of the different parameters described by the tests carried out. conditions: Dementia of Alzheimer Type conditions: Dementia conditions: Dementia, Vascular conditions: Dementia, Mixed conditions: Dementia Frontal conditi... |
<|newrecord|> nctId: NCT06378359 id: IDIM-2023-32364 briefTitle: Effectiveness of Screening and Decolonization of S. Aureus to Prevent S. Aureus Surgical Site Infections in Surgery Outpatients overallStatus: RECRUITING date: 2024-01-29 date: 2025-12-31 date: 2026-12-31 date: 2024-04-22 date: 2024-04-22 name: University... |
The study will compare four different approaches, Arm 1) screen for SA carriage and using the three-drug decolonization bundle for 5 days among patients with SA colonization, non SA carriers in this arm will get two pre-op showers with CHG soap, Arm 2) all participants receive the three drug decolonization bundle, Arm ... |
The primary efficacy outcome will be eradication of SA colonization at all 5 body sites. Secondary outcomes will be SA surgical site infections (SSIs), all SSIs, and SA healthcare associated infections (HAIs). The study will also compare eradication of SA from each of the 5 body sites as a secondary outcome. conditions... |
<|newrecord|> nctId: NCT06378346 id: 2023-077 briefTitle: GU-01: Glycyrrhizin in Prostate Cancer acronym: GU-01 overallStatus: RECRUITING date: 2024-05 date: 2026-03 date: 2026-03 date: 2024-04-22 date: 2024-04-26 name: University of Illinois at Chicago class: OTHER briefSummary: This is a pilot, randomized, window-of-... |
<|newrecord|> nctId: NCT06378333 id: 2024-01-023 briefTitle: Incidence, Clinical Characteristics and Outcomes of Unstable Angina in the contempoRary Area. acronym: ICAR overallStatus: COMPLETED date: 2022-11-27 date: 2024-01-27 date: 2024-04-15 date: 2024-04-22 date: 2024-04-22 name: University Hospital, Montpellier cl... |
<|newrecord|> nctId: NCT06378320 id: STUDY20240287 briefTitle: eHealth for Breastfeeding Support - the HOTSPOT Trial overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2025-06-01 date: 2025-06-01 date: 2024-04-22 date: 2024-04-22 name: University Hospitals Cleveland Medical Center class: OTHER briefSummary: This ... |
The purpose of the app (which is currently in clickable "wireframe" status, a "pre" app phase) is to support and promote breastfeeding specifically for mothers and fathers/partners who are African American or Black. Other breastfeeding apps have pictures mainly of White or Asian mothers and information that is not orie... |
Up to 24 participants will be enrolled at UHCMC, including up to 20 mothers. Other participants will include up to 4 African American or Black fathers/partners whose partners are interested in breastfeeding. conditions: Breast Feeding studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALL... |
<|newrecord|> nctId: NCT06378307 id: CHUBX2022-06 briefTitle: A Transferability Study on the Conditions for a Successful Inclusive Education acronym: TIAP overallStatus: NOT_YET_RECRUITING date: 2024-04-30 date: 2025-06-30 date: 2025-06-30 date: 2024-04-22 date: 2024-04-22 name: University Hospital, Bordeaux class: OTH... |
<|newrecord|> nctId: NCT06378294 id: UHACoruna briefTitle: Locoregional Control With Radiotherapy of Breast Cancer Patients With MACrometastases Treated With MAstectomy (MACMA) acronym: MACMA overallStatus: RECRUITING date: 2021-04-20 date: 2024-12-31 date: 2029-12-31 date: 2024-04-22 date: 2024-04-25 name: University ... |
The ACOSOG-Z0011 and the AMAROS trial demonstrated that SLNB with or without radiotherapy provided equivalent local control and survival to axillary lymph node dissection (ALND) in early-stage breast cancer patients with 1 or 2 positive SLNs. However, the ACOSOG-Z0011 trial did not included patients treated with mastec... |
The investigators conduct an observational cohort study of early stage breast cancer patients receiving upfront mastectomy with 1 or 2 macrometastases after SLNB. The study aim to demonstrate a 5-year disease-free survival of not less than 80% when ALND is omitted and replaced by axillary radiotherapy, and determine th... |
<|newrecord|> nctId: NCT06378281 id: CRSK-3_221381 briefTitle: Testing a New Method to Improve Informed Consent in Prison Research acronym: Spark BATIR overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-04-30 date: 2025-09-30 date: 2024-04-22 date: 2024-04-24 name: Stéphanie Baggio class: OTHER name: Univers... |
<|newrecord|> nctId: NCT06378268 id: 05/24/DD-BVMD briefTitle: PPOS vs GnRH Antagonist in Ovarian Stimulation (ProGanOS Study) acronym: ProGanOS overallStatus: RECRUITING date: 2024-04-24 date: 2025-12-31 date: 2026-09-30 date: 2024-04-22 date: 2024-04-26 name: Mỹ Đức Hospital class: OTHER briefSummary: This non-inferi... |
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