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The aim of the study is to evaluate whether the adoption of two different models of Mediterranean Diet, based on the different percentage of carbohydrates and lipids, associated with a program of moderate intensity aerobic physical exercise, in patients with obesity and NAFLD can exercise, after only 3 months, effects ... |
* specific aspects associated with NAFLD, such as the degree of hepatic steatosis and fibrosis; |
* circulating levels of molecules correlated with the degree of generalized and hepatic inflammation and the blood concentrations of metabolic and cardiovascular risk factors associated with abdominal obesity; |
* intestinal barrier; |
* body composition; |
* intestinal microbiota; |
* symptoms of IBS (irritable bowel syndrome) in patients with NAFLD. conditions: NAFLD conditions: Obesity conditions: IBS studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The study evaluates the effects of two different Mediterranean Diet models, bas... |
The Mediterranean Diet is associated with a program of moderate intensity aerobic physical exercise (walking) carried out 3 times a week for 3 months. primaryPurpose: TREATMENT masking: NONE count: 60 type: ESTIMATED name: Mediterranean diet and moderate intensity physical exercise (outdoor walking). measure: The effec... |
<|newrecord|> nctId: NCT06275893 id: ACM01 briefTitle: IC14 (Atibuclimab) in Arrhythmogenic Cardiomyopathy overallStatus: RECRUITING date: 2024-03-29 date: 2025-02-01 date: 2025-08-01 date: 2024-02-23 date: 2024-04-02 name: Implicit Bioscience class: INDUSTRY briefSummary: The goal of this clinical trial is to test IC1... |
Participants will be asked to undergo screening and baseline testing, then receive 4 intravenous infusions with blood measurements before and after the infusion (including 24, 48, and 72 hours and 7, 14, and 28 days). Participants will be offered specialized scanning of the heart muscle, and will be asked to provide re... |
<|newrecord|> nctId: NCT06275880 id: F-2023-3201-066 briefTitle: Intraarticular Collagen in Patients With Gonarthrosis overallStatus: COMPLETED date: 2023-04-01 date: 2023-07-30 date: 2024-01-10 date: 2024-02-23 date: 2024-02-23 name: Instituto Mexicano del Seguro Social class: OTHER_GOV briefSummary: The objective of ... |
1. - Document the effectiveness of intra-articular polyvinylpyrrolidone collagen in the treatment of symptomatic gonarthrosis. |
2. - Compare the intensity of pain, the degree of stiffness and functionality of the joint, prior to application and one month after the therapeutic intervention. |
3. - Identify demographic, clinical and therapeutic factors that influence the effectiveness of intra-articular PVP collagen in the treatment of symptomatic gonarthrosis. |
Patients diagnosed with symptomatic gonarthrosis Grade II-IV, referred to the Physical Medicine and Rehabilitation service within 3 months, will be selected. Two study groups will be assigned: GROUP those who received intra-articular infiltration of PVP Collagen, GROUP B: patients who received conservative treatment. T... |
<|newrecord|> nctId: NCT06275867 id: SOPRIMA//T023635 briefTitle: Improved Access to Quality Care and Healthcare Use overallStatus: RECRUITING date: 2024-01-20 date: 2024-06-10 date: 2024-08-30 date: 2024-02-23 date: 2024-02-23 name: London School of Economics and Political Science class: OTHER name: University of Witw... |
<|newrecord|> nctId: NCT06275854 id: 22265 briefTitle: YASU Research Registry: For Young Adults With Cancer overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2030-05-01 date: 2030-05-01 date: 2024-02-23 date: 2024-02-23 name: Young Adult Survivors United class: OTHER name: Staunton Farm Foundation name: Elsie H.... |
* What are the levels of depression, anxiety, social support, and financial distress |
* Determine effectiveness of YASU programming by measuring changes over time |
With this registry, the investigators also plan to identify survivors who may be eligible for participation in future research studies pertaining to young adult cancer. |
Participants will be asked to complete electronic surveys every 6 to 12 months during participation in the registry. conditions: Cancer conditions: Leukemia conditions: Sarcoma conditions: Germ Cell Cancer conditions: Lymphoma conditions: Colorectal Cancer conditions: Melanoma conditions: Breast Cancer studyType: OBSER... |
<|newrecord|> nctId: NCT06275841 id: C4891035 briefTitle: A Study to Learn If the Study Medicine Esomeprazole Changes How the Body Processes the Other Study Medicine Vepdegestrant overallStatus: RECRUITING date: 2024-02-23 date: 2024-05-03 date: 2024-05-24 date: 2024-02-23 date: 2024-03-22 name: Pfizer class: INDUSTRY ... |
All participants in this study will receive one dose of vepdegestrant alone by mouth in Period 1. In Period 2, everyone will receive esomeprazole by mouth once a day for multiple days. Participants will also receive one dose of vepdegestrant by mouth. The levels of vepdegestrant in Period 1 will be compared to the leve... |
<|newrecord|> nctId: NCT06275828 id: PoliceGeneralHospiral briefTitle: The Effect of Perioperative and Postoperative Music Reduces Pain Perception After Anterior Cruciate Ligament Reconstruction overallStatus: ACTIVE_NOT_RECRUITING date: 2022-12-15 date: 2023-07-31 date: 2024-02-20 date: 2024-02-23 date: 2024-02-23 nam... |
<|newrecord|> nctId: NCT06275815 id: R01DC020958 type: NIH link: https://reporter.nih.gov/quickSearch/R01DC020958 briefTitle: Promoting Caregiver Implementation of an Effective Early Learning Intervention overallStatus: RECRUITING date: 2024-04-10 date: 2028-07-31 date: 2028-07-31 date: 2024-02-23 date: 2024-04-12 name... |
* how much STAR impacts children's literacy skills in the short-term and long-term--up to two-years after completing STAR. |
* how do caregiver supports in the form of small monetary rewards or encouraging texts help caregivers to implement STAR at its intended frequency of sessions per week. |
Caregiver participants will be assigned to either a control group or one of three STAR groups. Children's skills related to literacy and learning will be assessed before the intervention starts, at the end of the intervention, and every six months post-intervention for two years. |
Researchers will determine the short term and long term impacts of STAR compared to the control group. Researchers will compare the three STAR conditions to see if the rewards or encouragement helped parents to follow through with completing more STAR sessions. conditions: Developmental Language Disorder conditions: Re... |
<|newrecord|> nctId: NCT06275802 id: 22-5.1T/2 briefTitle: The Effect of Nutrition Education Interventions for Adolescents overallStatus: RECRUITING date: 2022-06-06 date: 2023-12-30 date: 2024-06-30 date: 2024-02-23 date: 2024-02-23 name: Ege University class: OTHER briefSummary: The aim of this study is to determine ... |
<|newrecord|> nctId: NCT06275789 id: 2023-268 briefTitle: Mix of Demineralized Freeze-Dried Bone Allograft and Deproteinized Bovine Bone Mineral: a Possible Solution for Alveolar Ridge Preservation? overallStatus: RECRUITING date: 2024-01-26 date: 2025-06 date: 2025-06 date: 2024-02-23 date: 2024-04-09 name: Nova South... |
<|newrecord|> nctId: NCT06275776 id: OC-2022-005 briefTitle: HIP-STITCH (Wound Recovery After THA) overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2028-03-01 date: 2028-05-01 date: 2024-02-23 date: 2024-03-05 name: Reinier Haga Orthopedisch Centrum class: OTHER briefSummary: This prospective randomised trial w... |
This will be done by assessing photographs of the plaster and photographs of the operation wound with a self-developed classification model. The photographs of the plaster will be taken by the test subject at home at 3 days and 11 days postoperatively. |
The photographs of the operation wound will be taken by a member of the research team, and the doctor's assistant, respectively, during a visit to the outpatient clinic at 7 days and 14 days postoperatively. |
Hypothesis: Monocryl sutures give the highest amount of aberrant wound recovery within fourteen days after primary THA. conditions: Wound Healing Disturbance of studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Test subjects are randomised into one of ... |
<|newrecord|> nctId: NCT06275763 id: 2020/ABM/01/00037 briefTitle: Optimal Medical Treatment of Difficult-to-treat Hypertension acronym: OPTIMAL-HT overallStatus: RECRUITING date: 2023-10-20 date: 2025-12-01 date: 2025-12-31 date: 2024-02-23 date: 2024-02-23 name: National Institute of Cardiology, Warsaw, Poland class:... |
<|newrecord|> nctId: NCT06275750 id: CEI 175/23 briefTitle: Non-surgical Spinal Decompression in Patients With Chronic Low Back Pain overallStatus: COMPLETED date: 2023-08-21 date: 2023-11-29 date: 2024-01-11 date: 2024-02-23 date: 2024-02-23 name: Hospital Civil de Guadalajara class: OTHER briefSummary: The goal of th... |
The main questions it aims to answer were: |
* Non-surgical spinal decompression is effective to reduce pain intensity and self-reported disability in patients with chronic low back pain and sciatica? |
* Age, level of education and work activities are related with clinical outcome in patients treated with non-surgical spinal decompression? |
Participants underwent eight sessions, three per week, with the BTL-6000 spinal decompression system. The study did not have a comparison group. conditions: Low Back Pain conditions: Sciatica conditions: Lumbar Disc Herniation studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPu... |
<|newrecord|> nctId: NCT06275737 id: POP-UP G-128 briefTitle: POP-UP: a Single-arm, Two-cohort Study: Trimodal Prehab for Upper GI and Pancreatic Cancer acronym: POP-UP overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2027-03 date: 2027-03 date: 2024-02-23 date: 2024-02-23 name: GERCOR - Multidisciplinary Oncology... |
<|newrecord|> nctId: NCT06275724 id: CKJX839A11401 briefTitle: Specified Drug-use Survey of Leqvio for s.c. Injection. overallStatus: RECRUITING date: 2024-03-04 date: 2027-12-31 date: 2027-12-31 date: 2024-02-23 date: 2024-04-26 name: Novartis Pharmaceuticals class: INDUSTRY briefSummary: The objective of this study i... |
<|newrecord|> nctId: NCT06275711 id: 223K003 briefTitle: The Effect of Therapeutic Communication Methods on the Psychological State of Children overallStatus: COMPLETED date: 2023-11-30 date: 2023-12-06 date: 2023-12-06 date: 2024-02-23 date: 2024-02-23 name: Gazi University class: OTHER name: The Scientific and Techno... |
Due to the earthquake that occurred on 6 February 2023 affecting 11 provinces in our country, the needs in the field vary. After the acute period (first 1 month), children need psychological support. Problems that cannot be solved in the early period may cause health and behavioural problems in children in later ages a... |
The aim of the study was to evaluate the effect of therapeutic communication programme on state and trait anxiety levels, psychological resilience, mental health and well-being of children aged 8-12 years affected by the earthquake. |
Hypotheses H1. After the therapeutic communication programme, children's State Anxiety Scale scores decrease. |
H2. After the therapeutic communication programme, children's Continuance Anxiety Scale scores decrease. |
H3. After the therapeutic communication programme, children's Me and My Emotions Scale scores decrease. |
H4. After the therapeutic communication programme, children's scores on the Child and Adolescent Psychological Resilience Scale increase. conditions: Psychological studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Pre-test post-test quasi-experimental stud... |
<|newrecord|> nctId: NCT06275698 id: RD2023-14 HONEY-POT id: 323188 type: OTHER domain: IRAS id: 56974 type: OTHER_GRANT domain: CPMS briefTitle: HONEY for the Treatment of POst-Tonsillectomy Pain acronym: HONEY-POT overallStatus: RECRUITING date: 2023-09-04 date: 2025-09-04 date: 2025-09-04 date: 2024-02-23 date: 2024... |
Main aim is to investigate a potential improvement in post-tonsillectomy pain control, with a low cost and freely available alternative to conventional analgesics. Recent systematic review and multidisciplinary consensus suggest a potential role for the inclusion of honey for this purpose. Clinical efficacy over placeb... |
Placebo - sugar-based syrup, thickened with sodium alginate and with honey flavouring, to be taken per-oral 15ml TDS for 14 days post-tonsillectomy. primaryPurpose: TREATMENT masking: TRIPLE maskingDescription: Intervention (Manuka honey) and placebo will be supplied in identical opaque jars with identical labels apart... |
Neither the patient nor the researcher collecting data will be aware of which arm the patient has been enrolled onto. whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: OUTCOMES_ASSESSOR count: 100 type: ESTIMATED name: Manuka honey MGO 1000 name: Sugar-based syrup, thickened with sodium alginate and flavoured ... |
<|newrecord|> nctId: NCT06275685 id: CIP-0001510 briefTitle: Forecasting Seizures Using Intelligent Wearable Technology for Health Tracking acronym: Foresight overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2026-06 date: 2026-06 date: 2024-02-23 date: 2024-02-23 name: Empatica, Inc. class: INDUSTRY briefSummary: ... |
The main questions it aims to answer are: |
* can we develop a future seizure probabilities tool that is more accurate than chance based on the pattern and frequency of previous generalized tonic-clonic seizure (GTCS) events, as well as changes in physiological and behavioral variables. |
* does this tool improve the lives of people with epilepsy? |
Researchers will compare a group that does not have access to the forecast tool to a group that does and see if it is accurate and if people with it report that it improved their quality of life. conditions: Epilepsy; Seizure studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primar... |
<|newrecord|> nctId: NCT06275672 id: TREAT INTERACT briefTitle: Implementing an Education- and Health System Task-shifting Approach for Child Mental Health Promotion in Uganda acronym: TREAT overallStatus: RECRUITING date: 2023-08-01 date: 2025-05 date: 2025-12 date: 2024-02-23 date: 2024-02-23 name: Norwegian Center f... |
<|newrecord|> nctId: NCT06275659 id: CT-100-D-003 briefTitle: An Exploratory Study to Evaluate a Digital Intervention to Disrupt Scratching in Atopic Dermatitis and Psoriasis overallStatus: ACTIVE_NOT_RECRUITING date: 2023-12-04 date: 2024-02-23 date: 2024-03-18 date: 2024-02-23 date: 2024-03-08 name: Click Therapeutic... |
DiNaMo components target key neural systems (including but not limited to systems related to sensory-, perceptual-, affective-, pain-, attention-, cognitive control, social- and self- processing) to optimally improve a participant's health. conditions: Psoriasis conditions: Atopic Dermatitis studyType: INTERVENTIONAL p... |
<|newrecord|> nctId: NCT06275646 id: Adeel2 briefTitle: Comparison Of Outcome Of Different Layers in Hypospadias Surgery overallStatus: COMPLETED date: 2022-01-01 date: 2022-12-31 date: 2023-04-01 date: 2024-02-23 date: 2024-02-23 name: Children Hospital and Institute of Child Health, Lahore class: OTHER briefSummary: ... |
<|newrecord|> nctId: NCT06275633 id: H-18055648 briefTitle: Behavioural Profiling of Disease-related Cognitive and Motor Impairment in PD overallStatus: COMPLETED date: 2019-03-19 date: 2021-12-03 date: 2023-07-30 date: 2024-02-23 date: 2024-02-23 name: University Hospital Bispebjerg and Frederiksberg class: OTHER brie... |
Participants will be patients with Parkinson's Disease and healthy controls. It will be investigated if there is a difference between patients with a good measured Levodopa response and with a poor measured response. conditions: Parkinson Disease conditions: Medication conditions: UPDRS conditions: Motor Function condi... |
<|newrecord|> nctId: NCT06275620 id: AGTC-RPGR-001 DAWN briefTitle: A Study Comparing Two Doses of AGTC-501 in Male Participants With X-linked Retinitis Pigmentosa Caused by RPGR Mutations (DAWN) overallStatus: ENROLLING_BY_INVITATION date: 2023-11-14 date: 2025-07 date: 2029-08 date: 2024-02-23 date: 2024-03-21 name: ... |
<|newrecord|> nctId: NCT06275607 id: FY23-24-93 briefTitle: Maladaptive Anger Treatment overallStatus: RECRUITING date: 2024-02-07 date: 2025-12-31 date: 2025-12-31 date: 2024-02-23 date: 2024-02-23 name: The University of Texas at San Antonio class: OTHER briefSummary: From a psychoevolutionary perspective, anger is a... |
<|newrecord|> nctId: NCT06275594 id: YUMC2023-12-017 briefTitle: Trial Evaluating the Efficacy of Remimazolam in Endobronchial Ultrasound Guided Transbronchial Needle Aspiration acronym: REST overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2025-02-01 date: 2025-02-01 date: 2024-02-23 date: 2024-02-23 name: Yeu... |
Primary Outcome Evaluate and compare the success of the procedure in patients undergoing EBUS-TBNA (Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration) when administered with remimazolam in the experimental group, versus Real world midazolam (Control Group 1), and On label midazolam (Control Group 2). |
Secondary Outcome In patients undergoing EBUS-TBNA, compare the following aspects when administered with remimazolam in the experimental group versus Real world midazolam (Control Group 1) and On label midazolam (Control Group 2): Procedure start time, Time taken to achieve full alertness, Need for flumazenil administr... |
<|newrecord|> nctId: NCT06275581 id: CR15_15 (EM-11-050055) briefTitle: Clinical Evaluation of the Performance of a Newly Developed Glass Ionomer Restorative for Posterior Restorations in an Adult Population overallStatus: TERMINATED date: 2017-06-14 date: 2021-03-24 date: 2021-10-01 date: 2024-02-23 date: 2024-02-23 n... |
STUDY OBJECTIVES Objective of the study is to evaluate the clinical survival and quality parameters of Class II Ketac Universal restorations compared to intra-individual (split-mouth) Class II Ketac Molar Quick control restorations over time STUDY ENDPOINTS |
Primary Endpoint: |
1. Evaluation of restoration survival over time based on the glass ionomer restoration criteria (simplified FDI criteria as proposed by Mathilde Peters et al.) |
Secondary Endpoints: |
1. Evaluation of restoration quality based on the glass ionomer restoration criteria (simplified FDI criteria) |
2. Evaluation of restoration wear based on comparison of digital impressions |
Safety Endpoint: |
1. Evaluation of potential adverse events NULL HYPOTHESIS There is no statistically significant difference between both glass ionomers |
* regarding overall survival |
* regarding restoration quality parameters TEST GROUP Ketac Universal Aplicap Glass Ionomer Restorative (3M) CONTROL GROUP Ketac Molar Quick Aplicap Glass Ionomer Restorative (3M) |
* regarding restoration wear METHODS AND MATERIALS A total of 39 subjects were enrolled and treated. The study was originally planned with 80 patients. Due to slow recruitment, it was decided to decrease the number of patients. |
Treatment: |
After signing informed consent, test and control product were randomly assigned to the two study teeth (randomization letter). Restoration extension (e.g. mod) and reason for restoration placement (e.g. secondary caries, tooth fracture) were recorded in the CRF. Two teeth per subject were included. Each product was use... |
Evaluation periods: |
All subjects were evaluated by two independent evaluators according to Performance Criteria for Posterior Glass Ionomer Restorations (simplified FDI criteria) |
* at baseline at day of restoration placement or up to 1 month after restoration placement |
* after 6 months (± 1 months) |
* after 1 year (± 1 months) |
* after 2 years (± 1 months) In addition, photos (at least occlusal view) were taken of every study tooth prior to restoration placement and at every evaluation. |
In order to further assess the wear of both restorative materials, full arch digital impressions (both upper and lower jaw) were taken at baseline evaluation and at every following evaluation using 3M True Definition Scanner. STL files were digitally compared to those taken at baseline. conditions: Tooth Wear condition... |
<|newrecord|> nctId: NCT06275568 id: HSC-SPH-23-0655 briefTitle: Accelerating Healthcare Engagement in Healthy Food Interventions - Food Rx in High Risk Pregnant Mothers With About Fresh and Texas Children's Health Plan overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2024-11-15 date: 2024-11-15 date: 2024-02-2... |
<|newrecord|> nctId: NCT06275555 id: 2023-101 briefTitle: Use of Bivalirudin for Anticoagulation in Patients With Extracorporeal Membrane Oxygenation overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2025-03-01 date: 2025-12-31 date: 2024-02-23 date: 2024-02-26 name: Xiaotong Hou class: OTHER briefSummary: The p... |
<|newrecord|> nctId: NCT06275542 id: USurabaya briefTitle: Ability to Maintain Saturation Levels Without Oxygen Supplementation as a Extubation Criteria Without TOF Monitoring Equipment overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-12-01 date: 2026-01-01 date: 2024-02-23 date: 2024-02-23 name: Universit... |
* Comparison 1: The volatile anesthetic gas used was sevoflurane and the muscular blockade agent used was rocuronium. |
* Comparison 2: The volatile anesthetic gas used was isoflurane and the muscular blockade agent used was rocuronium. |
* Comparison 3: The volatile anesthetic gas used was sevoflurane and the muscular blockade agent used was atracurium. primaryPurpose: PREVENTION masking: DOUBLE maskingDescription: Upon arrival in the recovery room, all subjects were fitted with SpO2, EKG, NIBP monitors, and the TOF monitoring device. TOF values were m... |
<|newrecord|> nctId: NCT06275529 id: 27.12.2023.685 briefTitle: Evaluation of Transforaminal Epidural Steroid Injection in Radicular Low Back Pain According to MSU Classification overallStatus: NOT_YET_RECRUITING date: 2024-03-15 date: 2024-06-15 date: 2024-08-15 date: 2024-02-23 date: 2024-02-23 name: Başakşehir Çam &... |
The aim of this study to evaluate the pain and oswestry disability index in patients who have radiculopathy with low back pain, undergone TFSI according to MSU classification. conditions: Radiculopathy Lumbar conditions: Low Back Pain conditions: Disc Herniation conditions: Injections, Epidural studyType: INTERVENTIONA... |
<|newrecord|> nctId: NCT06275516 id: 2024-208 briefTitle: Safety and Efficacy of Multisensory Stimulation Virtual Reality for Stroke Patients. overallStatus: NOT_YET_RECRUITING date: 2024-02-20 date: 2024-06-20 date: 2024-09-20 date: 2024-02-23 date: 2024-02-23 name: First Affiliated Hospital of Chongqing Medical Unive... |
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