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* WES conditions: Genetic Disease studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Single group, multiple interventions. All enrollees receive all interventions. primaryPurpose: SCREENING masking: NONE count: 120 type: ACTUAL name: Whole genome sequencing... |
<|newrecord|> nctId: NCT06276335 id: IRAS:322440 briefTitle: Influence of Timing of Implant Placement on Early Healing Molecular Events overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2026-04-30 date: 2026-05-30 date: 2024-02-23 date: 2024-03-08 name: Queen Mary University of London class: OTHER name: Universi... |
The primary objective of this study is to describe changes in the expression of inflammatory, angiogenesis and osseous biomarkers of saliva at 1, 3, 7, 15 and 30 days and of PICF at 3, 7, 15 and 30 days after immediate implant placement (IP) compared with delayed placement (DP). conditions: Dental Implant conditions: H... |
<|newrecord|> nctId: NCT06276322 id: HU-FTR-SZK-01 briefTitle: Assessment of All Spine Segments ın Individuals With Low Back Pain overallStatus: RECRUITING date: 2023-12-01 date: 2024-03-20 date: 2024-12-31 date: 2024-02-23 date: 2024-03-07 name: Hacettepe University class: OTHER briefSummary: The aim of the study is t... |
<|newrecord|> nctId: NCT06276309 id: NECC2401 briefTitle: Protein Molecular Characteristics and Prognosis of Cervical Neuroendocrine Tumors overallStatus: RECRUITING date: 2024-02-01 date: 2024-06-30 date: 2024-06-30 date: 2024-02-23 date: 2024-02-23 name: Fujian Maternity and Child Health Hospital class: OTHER briefSu... |
<|newrecord|> nctId: NCT06276296 id: 0001 briefTitle: Heart Rate Variability After Ablation overallStatus: RECRUITING date: 2023-03-01 date: 2024-08-31 date: 2024-10-01 date: 2024-02-23 date: 2024-02-23 name: Charles University, Czech Republic class: OTHER name: Vascular surgery, University hospital Královské Vinohrady... |
<|newrecord|> nctId: NCT06276283 id: DZ2022E0006 briefTitle: DZD9008 In Combination With Bevacizumab in Locally Advanced or Metastatic NSCLC Patients With EGFR Mutation (WU-KONG29) overallStatus: RECRUITING date: 2023-02-15 date: 2025-05-31 date: 2026-02-28 date: 2024-02-23 date: 2024-02-23 name: Dizal Pharmaceuticals ... |
<|newrecord|> nctId: NCT06276270 id: PT-MUC-1_05-21 briefTitle: Multi-centre, Open-label, First-in-man Study With Mucopad HA overallStatus: RECRUITING date: 2023-12-12 date: 2024-12-31 date: 2024-12-31 date: 2024-02-23 date: 2024-02-23 name: Contipro Pharma a.s. class: OTHER briefSummary: The device´s intended use is t... |
<|newrecord|> nctId: NCT06276257 id: 2024-7301 briefTitle: Paravertebral Block for Mastectomy With Immediate Reconstruction overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2025-07 date: 2025-12 date: 2024-02-23 date: 2024-02-23 name: CHU de Quebec-Universite Laval class: OTHER briefSummary: Following a mastectomy... |
The main objective of this study is to compare two analgesic modalities, namely BPV (study modality) and usual analgesia (control modality), in patients undergoing total mastectomy with immediate reconstruction under general anesthesia with the aim of to evaluate their functional pain score at 24, 48 and 72 hours follo... |
<|newrecord|> nctId: NCT06276244 id: NM040-GUP19002 briefTitle: Trial Readiness and Endpoint Assessment in Congenital and Childhood Myotonic Dystrophy acronym: GUP19002 overallStatus: ACTIVE_NOT_RECRUITING date: 2020-07-08 date: 2024-04 date: 2024-04 date: 2024-02-23 date: 2024-02-23 name: Fondazione Serena Onlus - Cen... |
<|newrecord|> nctId: NCT06276231 id: SalbuEase briefTitle: Nebulized Salbutamol in Acute Renal Colic overallStatus: NOT_YET_RECRUITING date: 2024-07-01 date: 2026-03-01 date: 2026-05-01 date: 2024-02-23 date: 2024-03-19 name: Oman Medical Speciality Board class: OTHER_GOV briefSummary: A Prospective, double blinded, Ra... |
Research Summary: |
INTRODUCTION: Pain is a common reason for individuals to seek health care, especially emergency care. Salbutamol has an effect for smooth muscle relaxation of the ureters. The administration of Salbuatmol has been shown to be safe and effective in the treatment of asthma exacerbation, but there have been no studies eva... |
METHOD: This is a double blinded randomized clinical controlled trial. Two hundred renal colic patients presenting to the emergency department will be randomized to intervention (10 mg nebulized salbutamol) and (10 ml neublized Normal saline) case groups. Both the groups will get the standard treatment (IM diclofenac 7... |
AIM: The aim of this study is to compare analgesic effects of Nebulized Salbutamol versus Placebo in adult patients with renal colic. |
PRIMARY OJECTIVES: Analgesic effects of Nebulized Salbutamol on the Numerical Rating scale (NRS). |
SECONDARY OBJECTIVES: Adverse Events, the need of rescue pain medications and time to discharge. |
PATEINT POPULATION: Adults (from age 18 to 60 years) who presents to emergency department (ED) at Armed force Hospital with acute flank pain suggestive of renal colic |
INTERVENTION: Single dose of Nebulized Salbutamol 10mg. |
CLINICAL MEASURMENT: Numerical pain Analog Scale will be assessed at 0,15,30, 45 and 60 minutes after intervention. Number and dosage of rescue medication, any reported events by patient or attending physician will be documented. |
OUTCOME: Decrease in pain measures by NRS pain score after Nebulized Salbutamol is given, tolerability and safety evaluation. conditions: Renal Colic studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CAR... |
<|newrecord|> nctId: NCT06276218 id: PSU briefTitle: Efficacy of Self - Adjustable Clavicular Brace Versus Standard Clavicular Brace for Treatment of Mid Shaft Clavicle Fracture: A Randomized Controlled Study overallStatus: RECRUITING date: 2022-02-01 date: 2024-02-15 date: 2024-02-16 date: 2024-02-23 date: 2024-02-23 ... |
<|newrecord|> nctId: NCT06276205 id: 1037/RC/KEMU briefTitle: Vitamin D & Levothyroxine Combination Versus Levothyroxine on Lipid Profile in Hypothyroidism acronym: ViDaLLiT overallStatus: RECRUITING date: 2024-03-01 date: 2024-09-30 date: 2024-09-30 date: 2024-02-23 date: 2024-02-23 name: King Edward Medical Universit... |
The main question it aims to answer is: |
• whether adding Vitamin D to standard therapy has any additional benefits |
Participants will be given Vitamin D in replacement doses according to their pre-existing Vitamin D level in addition to levothyroxine. |
Researchers will compare them with another group receiving only levothyroxine to see how much lipids improve in them conditions: Hypothyroidism Primary conditions: Lipid Disorder conditions: Dyslipidemias studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATME... |
<|newrecord|> nctId: NCT06276192 id: 2023-01882-01 briefTitle: Digital Physiotherapy Treatment for Patients With Subacromial Pain Compared to Usual Physiotherapy in Primary Care acronym: diSAID overallStatus: NOT_YET_RECRUITING date: 2024-02-26 date: 2026-03-26 date: 2028-03-26 date: 2024-02-23 date: 2024-02-23 name: R... |
The main question this clinical trial aims to answer are: |
- Can the diSAID improve shoulder function and reduce pain for patients with subacromial pain in primary care? conditions: Subacromial Pain Syndrome conditions: Shoulder Pain conditions: Rotator Cuff Syndrome studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescri... |
<|newrecord|> nctId: NCT06276179 id: KFSIRB200-97 briefTitle: Epidural Oxycodone for Pain Management for Lower Limb Amputation overallStatus: RECRUITING date: 2024-02-24 date: 2024-08-01 date: 2024-08-01 date: 2024-02-23 date: 2024-02-28 name: Kafrelsheikh University class: OTHER briefSummary: The aim of this study is ... |
<|newrecord|> nctId: NCT06276166 id: 72374215 briefTitle: Trajectory of Frailty and Cognitive Dysfunction in Older Adults overallStatus: NOT_YET_RECRUITING date: 2024-03-15 date: 2026-06-30 date: 2026-12-31 date: 2024-02-23 date: 2024-03-07 name: Zheng Li class: OTHER briefSummary: To explore the heterogeneity of the d... |
<|newrecord|> nctId: NCT06276153 id: CRGGCext briefTitle: Construction of Multicenter Retrospective Registry Cohort Database for Gallbladder Cancer acronym: CRGGCext overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2027-02-28 date: 2029-02-28 date: 2024-02-23 date: 2024-02-28 name: RenJi Hospital class: OTHER b... |
<|newrecord|> nctId: NCT06276140 id: 4/23/2-4661/2-9 briefTitle: Iron-deficiency Anaemia and Its Impact on Recovery After Colorectal Cancer Surgery acronym: ID-COLO overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2026-01 date: 2026-01 date: 2024-02-23 date: 2024-02-28 name: Oncology Institute of Vojvodina class: ... |
* whether the presence of preoperative iron deficiency anaemia leads to a poorer quality of postoperative recovery in patients undergoing colorectal cancer surgery |
* whether different combinations of complete blood count parameters (red blood cell indices) could be suitable diagnostic tools for the detection of iron deficiency in the latent stage (without laboratory-confirmed anaemia) in colorectal cancer patients. |
Blood samples for laboratory analyses will be collected from each study patient admitted to the surgical ward one day prior to elective surgery and on the first postoperative day during the stay in the intensive care unit. The pre-operative laboratory analyses include a complete blood count and serum iron status parame... |
Data about overall morbidity, intraoperative complications, quality of postoperative recovery, red blood cell transfusion rate, all-cause infection rate, antibiotic usage, as well as length of hospital stay will be collected. |
The researchers will compare the group of patients with iron deficiency anaemia, the group of patients with iron deficiency in the latent stage and the control group to determine whether patients with iron deficiency have a higher incidence of perioperative complications and impaired recovery after surgery. The researc... |
<|newrecord|> nctId: NCT06276127 id: MERC301123 briefTitle: Oral Bisoprolol Vs IV Diltiazem in Atrial Fibrillation or Flutter With Rapid Ventricular Rate. acronym: BisoAF overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2026-04 date: 2026-06 date: 2024-02-23 date: 2024-03-05 name: Oman Medical Speciality Board cla... |
METHOD: This study is a randomized controlled trial targeting patients who present to the emergency room with symptomatic atrial fibrillation or flutter and rapid ventricular response requiring intervention. Participants will be split into two groups and undergo continuous monitoring of vital signs and regular electroc... |
AIM: Evaluate the efficacy and safety of oral bisoprolol in treating atrial fibrillation or atrial flutter with rapid ventricular response in an emergency department setting. |
PRIMARY OJECTIVES: The primary efficacy outcome will be evaluated by achieving a HR\<110 beats per minute or a decrease ≥20% of baseline HR at 60 minutes. The primary safety outcome measures are HR \< 60 bpm and SBP \< 95 mm Hg. |
SECONDARY OBJECTIVES: The use of Rescue medication, proportion of patients who required hospitalization, worsening of heart failure or pulmonary oedema, side effect of medication ( dizziness, headaches, gastrointestinal symptoms) |
PATEINT POPULATION: Adults (18 and older) presenting to the emergency department at Sultan Qaboos University Hospital with symptomatic atrial fibrillation or atrial flutter with rapid ventricular response requiring treatment. |
INTERVENTION: A single oral dose of 5 mg Bisoprolol (maximum dose of 5 mg) or a single intravenous dose of Diltiazem at 0.25 mg/kg (to a maximum dose of 30 mg). |
CLINICAL MEASURMENT: Heart rate recorded every 15 minutes up to the 90-minute mark, with a 12-lead ECG performed every 30 minutes. |
OUTCOME: For therapy to be considered effective, patients must achieve a ventricular rate ≤110/min or experience a drop-in ventricular rate of at least 20% at 60 minutes. conditions: Atrial Fibrillation With Rapid Ventricular Response conditions: Atrial Flutter With Rapid Ventricular Response studyType: INTERVENTIONAL ... |
* Participants: Patients with atrial fibrillation/flutter and rapid ventricular rate. |
* Treatment Arms: Oral Bisoprolol vs. Intravenous Diltiazem. |
* Randomization: Subjects randomly assigned to either treatment group. |
* Primary Endpoint: Reduction of heart rate to a target level within a specific timeframe. |
* Secondary Outcomes: Adverse effects, hospital admission rates, additional rate control needs. |
* Objective: Compare effectiveness and safety of oral Bisoprolol to intravenous Diltiazem. |
* Monitoring: Continuous observation of vital signs and electrocardiograms for safety. primaryPurpose: TREATMENT masking: DOUBLE maskingDescription: While the treating physician, nurse, and the patient will not be blinded to the treatment, the investigator collecting data and the statistician analysing it will remain b... |
<|newrecord|> nctId: NCT06276114 id: 07 briefTitle: IVL vs ELCA for Stent Underexpantsion (IVL-ELCA DRAGON) acronym: DRAGON overallStatus: COMPLETED date: 2020-08-01 date: 2023-10-31 date: 2023-10-31 date: 2024-02-23 date: 2024-02-23 name: Medical University of Silesia class: OTHER briefSummary: The IVL- ELCA DRAGON Re... |
The primary efficacy endpoint was device success (technical success with a final stent expansion ≥ 80%). Thirty days device-oriented composite endpoint (DOCE: cardiac death, target lesion revascularization, or target vessel myocardial infarction) was the secondary endpoint. conditions: Coronary Artery Calcification con... |
<|newrecord|> nctId: NCT06276101 id: NEWISH-HPV-101 briefTitle: NWRD08 DNA Plasmid for HPV-16 and/or HPV-18 Related Cervical HSIL overallStatus: RECRUITING date: 2024-01-25 date: 2024-12-30 date: 2025-07-30 date: 2024-02-23 date: 2024-02-23 name: Newish Technology (Beijing) Co., Ltd. class: INDUSTRY briefSummary: This ... |
<|newrecord|> nctId: NCT06276088 id: NFEC-2024-067 briefTitle: Plasma and Tissue SAA1 Levels in Cancer Patients to Predict Hyperprogression of Immunotherapy overallStatus: RECRUITING date: 2024-02-18 date: 2025-12-31 date: 2026-10-31 date: 2024-02-23 date: 2024-03-15 name: Nanfang Hospital, Southern Medical University ... |
<|newrecord|> nctId: NCT06276075 id: 10/KRN/2020 briefTitle: The Impact of Erigo®Pro Therapy and Motor Imagery on the Balance of Stroke Patients. overallStatus: COMPLETED date: 2022-12-15 date: 2023-05-10 date: 2023-09-10 date: 2024-02-23 date: 2024-02-23 name: Anna Olczak class: OTHER briefSummary: The aim of the stud... |
<|newrecord|> nctId: NCT06276062 id: Titanium nail usage briefTitle: Uses of Titanium Nail in Pediatric Fractures overallStatus: RECRUITING date: 2023-09-01 date: 2024-09 date: 2024-10 date: 2024-02-23 date: 2024-02-28 name: Sohag University class: OTHER briefSummary: The aim of this study is to investigate the short t... |
<|newrecord|> nctId: NCT06276049 id: DGETRRP2023-54 briefTitle: ChatGPT Helping Advance Training for Medical Students: A Study on Self-Directed Learning Enhancement acronym: CHAT-MS overallStatus: ACTIVE_NOT_RECRUITING date: 2023-11-25 date: 2024-01-06 date: 2024-03-02 date: 2024-02-23 date: 2024-02-23 name: Wang Shalo... |
How does LearnGuide influence SDL skills among medical students? Can LearnGuide improve critical thinking and learning flow as measured by Cornell Critical Thinking Test (CCTT) Level Z score and Global Flow Score (GFS)? |
Participants will: |
Undergo a two-hour introduction to LearnGuide. Engage in 12 weeks of SDL task-based training with LearnGuide\&#39;s support. |
If there is a comparison group: Researchers will compare the group utilizing LearnGuide for SDL and the group without this tool to see if there is a significant difference in SDL skills, critical thinking, and learning flow experiences. conditions: Self-Directed Learning conditions: Artificial Intelligence conditions: ... |
<|newrecord|> nctId: NCT06276036 id: CAPID briefTitle: Autoimmune Cytopenias as a Sign of Primary Immunodeficiency. overallStatus: ACTIVE_NOT_RECRUITING date: 2019-07-23 date: 2024-12-01 date: 2025-06-01 date: 2024-02-23 date: 2024-03-29 name: Meyer Children's Hospital IRCCS class: OTHER briefSummary: Autoimmune cytope... |
<|newrecord|> nctId: NCT06276023 id: 2023P003638 id: 1R01AG078204-01 type: NIH link: https://reporter.nih.gov/quickSearch/1R01AG078204-01 briefTitle: Supporting Our Caregivers In ADRD Learning (SOCIAL) acronym: SOCIAL overallStatus: RECRUITING date: 2024-03-22 date: 2025-03-15 date: 2025-04-01 date: 2024-02-23 date: 20... |
The main aim is to: Demonstrate feasibility, acceptability, credibility, fidelity, preliminary efficacy and evidence for proposed mechanism of MASC through a pilot randomized controlled trial. |
Relevant stakeholders (caregivers of persons with ADRD) will participate in the intervention. conditions: Alzheimer's Disease and Related Dementias conditions: Quality of Life conditions: Caregiver Stress studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: SINGLE_GROUP interventionModelDescri... |
<|newrecord|> nctId: NCT06276010 id: 2023-102 briefTitle: Use of Nafamostat Mesilate for Anticoagulation in Patients With ECMO overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2026-03-01 date: 2026-12-31 date: 2024-02-23 date: 2024-02-26 name: Xiaotong Hou class: OTHER briefSummary: The purpose of this study is... |
<|newrecord|> nctId: NCT06275997 id: GAIN briefTitle: GAIN Project: Gastric Cancer and Artificial Intelligence acronym: GAIN overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2026-03 date: 2028-03 date: 2024-02-23 date: 2024-02-23 name: Istituto Clinico Humanitas class: OTHER briefSummary: Our GAIN project comprise... |
The nation-level multi-center tandem randomized controlled trial (WP1) will contribute to a better understanding of how the real-time AI algorithm can reduce miss rate of early gastric cancer and dysplasia during gastroscopy. Moreover, the innovation project will contribute to development of a novel AI tool (WP2) that ... |
<|newrecord|> nctId: NCT06275984 id: PI23/00288 id: 4R23/440 type: OTHER domain: IDIAP Jordi Gol briefTitle: Effectiveness of Online Training in Cardiopulmonary Resuscitation Maneuvers for a Network of Volunteers. acronym: EFORCP overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2025-12 date: 2026-12 date: 2024-02-... |
Hypotheses: Online education in CPR maneuvers is an effective and efficient tool for training individuals from the general population on how to respond to cardiac arrests |
Objectives: The primary aim of this study is to assess the efficacy of online CPR and AED training within the general population of the province of Tarragona. Specific objectives include: 1) evaluating participants' theoretical and practical CPR skills in the short and medium term following online training, and 2) expl... |
Methodology:This study will unfold in several phases: 1) Online CPR-AED training and assessment of theoretical knowledge acquisition; 2) Evaluation of acquired practical CPR skills (know-how) within a simulation environment, conducted on a subset of the population completing phase 1;3)Analysis of the experiences of a s... |
Variables and determinations:The primary response variable for phase 1 will be the difference in scores obtained from the online questionnaire between the final (post-training) and initial (pre-training) assessments. |
In phase 2, the main variable will be the pass/fail categorization of scores in the simulation. This evaluation will be conducted by two members of the Advanced Clinical Simulation Unit at Joan XXII Hospital using a predefined checklist. Throughout the various phases of the study, socio-demographic data and course perf... |
Expected results: The research team for this study aims to ascertain the efficacy and effectiveness of online CPR-AED training within the general population. Furthermore, the study aims to provide evidence regarding the optimal duration and frequency for repeating such training. |
Applicability and Relevance: This proposal advocates for a significant and innovative project, given the dearth of literature on this topic. While there are existing indications and studies on CPR-AED training among specific populations such as students and healthcare professionals, the presented proposal seeks to broa... |
<|newrecord|> nctId: NCT06275971 id: KBSMC 2022-07-006 briefTitle: Effectiveness of Continuous Glucose Monitoring System Among Cardiac Surgery Patients overallStatus: RECRUITING date: 2022-11-24 date: 2024-06-30 date: 2024-08-31 date: 2024-02-23 date: 2024-02-23 name: Kangbuk Samsung Hospital class: OTHER name: DexCom,... |
<|newrecord|> nctId: NCT06275958 id: 2023-506115-17 id: 2023-506115-17 type: EUDRACT_NUMBER briefTitle: DOSAGE Study: Upfront Dose-Reduced Chemotherapy in Older Patients With Metastatic Colorectal Cancer acronym: DOSAGE overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2028-06 date: 2028-12 date: 2024-02-23 date: 2... |
Primary outcome is PFS. Secondary endpoints include grade ≥3 toxicity, QoL, physical functioning, overall survival, number of treatment cycles, dose reductions, hospital admissions, cumulative received dosage and cost-effectiveness. conditions: Older Patients conditions: Colorectal Cancer conditions: Metastatic Cancer ... |
<|newrecord|> nctId: NCT06275945 id: 1010073 briefTitle: Feasibility Study of A VoRo UrologIc ScaffolD (ARID) acronym: ARID overallStatus: RECRUITING date: 2023-04-03 date: 2026-07-30 date: 2026-10-30 date: 2024-02-23 date: 2024-02-23 name: Levee Medical, Inc. class: INDUSTRY name: RQMplus briefSummary: The objective o... |
The study is a prospective, multicenter, single arm study. Up to 40 subjects will be treated at up to 3 investigational sites in Panama. Subjects will be followed up post-treatment at catheter removal, 6 weeks post prostatectomy, 3 months, 6 months, 12 months and 2 years. conditions: Stress Urinary Incontinence conditi... |
<|newrecord|> nctId: NCT06275932 id: TermoNeo/2023 briefTitle: Management of Healthy Newborn's Body Temperature at Birth overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-04-01 date: 2025-05-31 date: 2024-02-23 date: 2024-02-23 name: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico class: OTHER br... |
Hypothermia at birth could cause risks or comorbidities such as an increased risk of infant mortality, hypoglycemia, sepsis, metabolic acidosis, respiratory distress syndrome (RDS) and intraventricular hemorrhage (IVH). |
One of the factors that affects heat loss in the delivery room is the relationship between surface area, volume and body mass of the newborn. The decrease in body temperature is directly related to gestational age and weight at birth; indeed, this problem is much more present in premature and/or low weight newborns at ... |
To date, the strategies that are implemented for the physiological newborn are documented in the literature are, in addition to the heat chain described by the World Health Organization (WHO), the implementation of skin-to-skin contact (skin to skin) mother-newborn. |
Some studies demonstrating the beneficial effect of this procedure on maintenance of the newborn's body temperature. |
The aim of this study is to evaluate two healthcare interventions to prevent heat loss of healthy newborns at birth. conditions: Newborn, Infant conditions: Body Temperature conditions: Delivery Room studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION maski... |
<|newrecord|> nctId: NCT06275919 id: IOV-BT-1-2023 MIRAGE briefTitle: Regorafenib for Recurrent Grade 2 and 3 Meningioma (MIRAGE Trial) acronym: MIRAGE overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2026-12 date: 2027-03 date: 2024-02-23 date: 2024-03-15 name: Istituto Oncologico Veneto IRCCS class: OTHER name: ... |
Small trials and case series suggest clinical relevant activity of several VEGF inhibitors such as sunitinib, bevacizumab and valatinib reporting a 6m-PFS rate of 42-64%. Indeed, VEGF and VEGF receptors (VEGFR) are regularly overexpressed in meningiomas and can correlate with outcome. |
Regorafenib inhibits angiogenic receptor tyrosine kinases (RTKs) and is highly selective for VEGFR1/2/3; moreover Regorafenib inhibits PDGFRB, FGFR1 and oncogenic intracellular signalling cascades involving c-RAF/RAF1 and BRAF highly expressed in meningiomas. |
Noteworthy, Regorafenib showed antitumor activity in vitro and in vivo in a recent study; indeed, Regorafenib showed significant inhibition of meningioma cell motility and invasion and in vivo, mice with orthotopic meningioma xenografts showed a reduced volume of signal enhancement in MRI following Regorafenib therapy;... |
Moreover, Regorafenib showed good efficacy in different cancer types, such as colorectal cancer, GIST, hepatocellular carcinoma and glioblastoma (REGOMA trial) , maintainingmaintaining a good quality of life. conditions: Meningioma, Malignant studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionM... |
<|newrecord|> nctId: NCT06275906 id: NAFLD-POS5 briefTitle: Influence of a Mediterranean Diet Combined With a Physical Activity Intervention, on NAFLD and Inflammation Parameters. acronym: NAFLD-POS5 overallStatus: NOT_YET_RECRUITING date: 2024-04-08 date: 2025-04-08 date: 2026-04-08 date: 2024-02-23 date: 2024-02-23 n... |
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