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This invention relates to an air conditioning system provided with a heat exchanger for dehumidification and a heat exchanger for cooling, and employing an open-type dehumidification air-cooling cycle. A prior art air conditioning system of this type is generally constructed as shown in FIG. 1. In FIG. 1, numeral 1 designates a room to be air-cooled. Air inside the room 1 is passed successively through a rotary heat exchanger 3 for dehumidification and a rotary heat exchanger 4 for cooling by means of a pipe 2, evaporation-cooled by a humidifier 5, and then returned to the room 1. On the other hand, the outside air is evaporation-cooled by a humidifier 6, and then led into the rotary heat exchanger 4. Thereafter, it is heated by a main heat source 7 and an auxiliary heat source 8, and then supplied to the rotary heat exchanger 3 and discharged into the outside space. In such a system, the air led from the room 1 is both dehumidified and heated as it passes through the rotary heat exchanger 3, and then is cooled as it passes through the rotary heat exchanger 4. Thereafter, it is further cooled by the humidifier 5 and returned to the room 1. Thus, the room 1 is cooled. In the prior art system of the above-mentioned construction, both of the heat exchangers for dehumidification and for cooling are of a rotary type, which requires great driving power. Accordingly, the system requires considerable total power consumption, and is generally complicated and bulky due to the use of the two sections to be driven.

A group of 10 NIH funded investigators request funds to purchase a laser scanning confocal microscope. The requested system consists of a Zeiss LSM510 equipped for Visible/Near UV imaging. The group is located in two departments at the Washington State University with research ties to the neighboring University of Idaho. 79 NIH funded investigators with a total of 102 active NIH grants are located in the region. The group shares access with the general research community to a BIORAD MRC1024 now in its seventh year of heavy use. 24 laboratories used the instrument in 2003, and newly recruited investigators with research emphasizing confocal imaging will add to the demand for this instrument beginning in 2004. In addition to lack of sufficient access for long-term time-lapse studies, the group is severely limited by technical requirements that cannot be met with the existing instrument. Among these are the ability to image more than two fluorescent probes simultaneously, increased detector sensitivity permitting study of living specimens and photolabile structure, the ability to detect UV excitable probes and the ability to assess protein-protein interaction using fluorescence resonance energy transfer (FRET) measurements. The user group includes investigators with extensive previous experience with the Zeiss LSM510 confocal microscope system at other institutions, and there is no question regarding its ability to serve the needs of our user group for the life-span of the instrument. The instrument will be housed in an established multiuser imaging facility known as the "EM center" which currently offers support by two full time staff members. It is anticipated that the user group requesting the instrument will use the instrument 75% of the time, but provisions will be made for use by non-group members as time permits. Policy for the instrument will be determined by an internal advisory committee, and day-to-day maintenance, technical supervision and instruction will be provided by staff members of the EM center. Service contracts over the next 5 years will be covered by a recharge system and through financial support from the Department of Veterinary, Comparative Anatomy, Pharmacology and Physiology. As the instrument becomes integrated into the user group's ongoing research programs, it is expected that service agreements will be maintained beyond the initial 5 year period by user fees.

Potential Intervention Targets in Utero and Early Life for Prevention of Hormone Related Cancers. Hormone-related cancers have long been thought to be sensitive to exposures during key periods of sexual development, as shown by the vulnerability to such cancers of women exposed to diethylstilbestrol in utero. In addition to evidence from human studies, animal studies using new techniques, such as gene knockout models, suggest that an increasing number of cancers may be hormonally related, including liver, lung, and bladder cancer. Greater understanding of sexual development has also revealed the "mini-puberty" of early infancy as a key period when some sex hormones reach levels similar to those at puberty. Factors driving sex hormones in utero and early infancy have not been systematically identified as potential targets of intervention for cancer prevention. On the basis of sex hormone pathways, we identify common potentially modifiable drivers of sex hormones, including but not limited to factors such as obesity, alcohol, and possibly nitric oxide. We review the evidence for effects of modifiable drivers of sex hormones during the prenatal period and early infancy, including measured hormones as well as proxies, such as the second-to-fourth digit length ratio. We summarize the gaps in the evidence needed to identify new potential targets of early life intervention for lifelong cancer prevention.

Neural dysfunction in ADHD with Reading Disability during a word rhyming Continuous Performance Task. Attention-Deficit/Hyperactivity Disorder (ADHD) is a heterogeneous, neurodevelopmental disorder which co-occurs often with Reading Disability (RD). ADHD with and without RD consistently have higher inattentive ratings compared with typically developing controls, with co-occurring ADHD and RD also demonstrating impaired phonological processing. Accordingly, inattention has been associated with greater phonological impairment, though the neural correlates of the association are poorly understood from a functional neuroimaging perspective. It was postulated that only the co-occurring subgroup would demonstrate hypoactivation of posterior, left hemispheric, reading-related areas and, to a lesser extent, alterations in right hemispheric, attention areas compared with controls. A novel word rhyming Continuous Performance Task assesses functional activation differences in phonology- and attention-related areas between three groups: ten boys with ADHD and RD, fourteen boys with ADHD without RD, and fourteen typically developing controls. Subjects respond to words that rhyme with a target word as mono- and disyllabic, English words are visually presented over 90s blocks. Behavioral performance was not different between groups. Some hypoactivation of left hemispheric, reading-related areas was apparent in ADHD and RD, but not ADHD without RD, compared with controls. Right hemispheric, attention areas showed alterations in both ADHD subgroups relative to controls; however, the differences for each subgroup were dissimilar. The dorsal decoding subnetwork may not be grossly compromised in ADHD with Reading Disability. The role of cognitive impairments, including the level of inattention, on phonology requires clarification from a neuroimaging perspective.

This application claims priority from European Patent Application No. 98 121 033.9 filed Nov. 5, 1998. The invention relates to a method and an apparatus for shrinking a foil onto an object as defined in the preamble of claim 1 and/or the preamble of claim 10. Such a method and/or such an apparatus mostly are used for packaging objects which are packaged prior to further transport in order to protect them against environmental influences and to increase stability of the packaged object. Generally plants for packaging objects are known in which a shrinking means essentially is formed by an annular shrink frame on which a plurality of heating elements, like gas burners, electroheater bodies or the like, is arranged. For packaging an object, the shrink frame is laterally moved along an object over which a foil hood was pulled. Therein, for shrinking said foil hood the heating means is switched on and the shrink frame is moved along said foil hood in vertical direction such that the foil hood shrinks under the influence of heat and bears on the object. An essential disadvantage lies in that in case of packagings which are unfitted or are provided with different foil thicknesses varying heat charge of the sides of the packaging occurs, as also is the case with packagings not having a basic area of axial symmetry. As furthermore the shrink frame is not build rigidly, by the known apparatus only an object of uniform size can be packaged, since in case of smaller objects the distance to the heating means becomes to large for reaching the shrinking temperature and in case of an object which is to big, the distance to the heating means is to small such that holes are created in the foil or the foil even can be ignited. The uniform energy supply in addition has the further disadvantage that the energy consumption in unnecessarily high as it cannot be adapted to the individual demands during shrinking of a foil onto an object. It is, therefore, the object of the present invention to create a method and apparatus for shrinking of a foil onto an object, in which the energy consumption is minimized and objects of different sizes in particular can be provided with a shrunk-on fail. This object is solved with a method with the features of claim 1 and with an apparatus with the features of claim 10. Preferred embodiments of the invention are cited in the subclaims. In accordance with the method according to the present invention, at least sectionally the temperature of the foil is measured for regulating the heat emission from the heating means to the foil. This permits an individual adaptation of the energy supply during shrinking such that in case of low heat demand for shrinking the foil, energy supply can be reduced and thus the all-over energy consumption of the apparatus is reduced. In addition, by the regulation of the heat emission to the foil the latter can be arranged at different distances with respect to the heating means such that objects of different sizes can be provided with a shrunk foil. In particular, objects with an irregular lateral surface can be provided with a shrunk-on foil better, as in protruding areas heat emission is reduced and in areas recessed with respect to the heating means heat emission can be increased. The advantage of the adjustable heating means additionally lies in that not only different objects can be covered with a shrunk foil but that the apparatus can adapt itself to the position of the object in relation to the heating means. It even is possible also to cover an object not arranged centrally with respect to the heating means, with a shrunk foil without problem, Furthermore, the method can be used for different foil thicknesses or foil materials, as the heat supply respectively is optimally adjustable to the foil. The regulation of the heat emission of the heating means therein permits an energetically optimized shrinking method independently from the ambient temperature and other environmental influences. In accordance with a preferred embodiment of the method in accordance with the present invention as defined in claim 1, the temperature to be reached, of the foil essentially is adjusted to a range somewhat above the shrinking temperature in order to minimize energy consumption during shrinking and simultaneously guaranteeing efficient shrinking. Preferably, heat emission of the heating means is regulated by the temperature of the latter. Alternatively, however, also the speed of the heating means in relation to the foil or the distance of the heating means to the foil can be regulated. The individual parameters can also be regulated in combination with one another. If, e.g. the object essentially is of ashlar shape, it is possible in a preferred embodiment of the invention to measure the temperature at least in the central area of each lateral surface. In case of objects of ashlar shape the foil surrounding the object arches to the outside in the central area such that in the central area the distance to the heating means is smallest. For safety reasons, therefore, at least in the central area a temperature measurement means should be provided for in order to avoid creation of holes or ignition of the foil. A simple realization of regulation of heat supply can be achieved, when the heating means consists of several gas burners and regulation of the heat emission is effected by regulation of the volume flow of the gas. In accordance with the apparatus according to the present invention a means for measuring the temperature of the foil and a means for regulating The temperature of the foil are provided for such that the heat emission of the heating means during shrinking can be optimally regulated in correspondence with the respective demands. In particular, the constructional additional expenses due to the additional means are kept into warrantable limits. Preferably, heat emission of the heating means can be regulated by the means for regulating the temperature of the foil, wherein alternatively or additionally also the speed of the heating means with respect tot he foil or the distance of the heating means to the foil can be adjustable. The apparatus can be adjusted to the demands in most flexible manner, if the temperature as well as the speed and the distance can be regulated. Preferably, the means for measuring the temperature includes several measuring units which each are arranged in the central area of the lateral surfaces of shrink frame e.g. annularly surrounding a good to be packaged. In an ashlar object the distance to the heating means is smallest in the central area, since the foil in this area arches away from the object. Furthermore, an air cushion exists between the foil and the object such that this area is particularly suitable for shrinking without heating the object itself. An individually controllable heating means includes several gas burners and/or electroheating bodies, infra-red radiators or the like, which are arranged in or on a shrink frame. By the individual control of the heat emission of the individual heater bodies an almost equal temperature can be achieved at the lateral surfaces of the object to be packaged even if these lateral surfaces e.g. have a varying distance to the heater bodies due to an irregular contour of the object, Even a change of the contour over the height of the object to be packaged does not cause a change in the shrinking temperature of individual foil areas. Thus, also an accurate adjusting of the object to be packaged with respect to the shrink frame is no longer required. Preferably, a cooling blower means for cooling the foil is arranged adjacent to the heating means such that the cooling blower means can blow away a rising stream of heated air which maybe could falsify the measuring results, A particularly simple and reliable means for measuring the temperature of the foil is an infra-red measurement means.

Well-being and prejudice toward obese people in women at risk to develop eating disorders. The literature has found that eating disorders (ED) patients usually have a depression and anxiety diagnosis. However, not many investigations have studied the relationship between ED and well-being. One of the main problems of patients with ED is their body image. These individuals usually see themselves too big but there are not many investigations that focus on how these patients see people with real weight problems. For this reason in this study it is analyzed how women in risk to develop ED see obese people. 456 female students were selected. It was found that women with high scores in the different subscales of the Eating Attitudes Test 26 (EAT-26; dieting, bulimia and oral control) had lower well-being (both subjective and psychological) and worse attitudes toward obese people (measured with Antifat Attitudes Test, AFA, Beliefs About Obese People Scale, BAOP, and Attitudes Toward Obese People Scale, ATOP) compared with women with low scores in the EAT-26.

The present invention relates to a method for the preparation of a lanthanum manganite powder which is useful as a material of various kinds of catalysts, electrodes and the like mainly in the form of a sintered body. It is conventional that a powder of lanthanum manganite, which is sometimes partially substituted by strontium to have a composition formula of (La.sub.1-x Sr.sub.x).sub.y MnO.sub.z, in which x is 0 or a positive number not exceeding 0.5, y is a positive number in the range from 0.8 to 1 and z is a positive number not exceeding 3, is prepared by blending powders of each of a specified and weighed amount of lanthanum oxide, manganese carbonate and, optionally, strontium carbonate by a dry process, wet process or a combination of both and calcining the powder blend at a temperature of 1200.degree. C. or higher. The above described conventional method for the preparation of a lanthanum manganite powder has problems in several respects. For example, it is almost unavoidable that a considerable portion of the starting powders remains unreacted in the product obtained by calcination and the amount of the unreacted starting materials can hardly be undetectably small even by conducting the process of calcination at a higher temperature for a longer length of time than usually undertaken. When a lanthanum manganite powder contains a substantial amount of unreacted lanthanum oxide, the sintered body prepared therefrom has a greatly decreased mechanical strength or the electric properties of the sintered body are very adversely affected. Disadvantages are also unavoidable by the high temperature calcination even when the lanthanum manganite powder is to be used in the form of a powder as such as in the applications for thermal spraying and the like because, even by setting aside the costs for the calcination at such a high temperature for a long time, growth of particles is unavoidable in the powder blend to give a semi-sintered mass of coarse particles which must be disintegrated and finely pulverized. As a remedy for the above described disadvantages, Japanese Patent Kokai 4-74721 proposes a method for the preparation of a strontium-substituted lanthanum manganite powder in which an aqueous solution of water-soluble compounds of lanthanum, strontium and manganese in a specified proportion is admixed with an aqueous solution of ammonium carbonate to precipitate a composite carbonate and the precipitates are collected by filtration, dried and calcined to give a lanthanum manganite powder. A problem in the lanthanum manganite powder obtained by this method is that, although the amount of the unreacted starting materials in the thus produced powder can be small enough, the product powder is poor in respect of the flowability behavior so that the powder is not suitable for use, for example, in thermal spraying in which good flowability of the refractory powder is essential, for example, in order not to cause bridging of the powder in the feeder hopper.

Workplace health promotion: what public-sector employees want, need, and are ready to change. To examine whether employees selected appropriate health change targets (HCTs) compared with self-reported lifestyle factors (smoking, nutrition, alcohol, physical activity [PA], sedentariness, weight status, and psychological distress) and readiness to change their HCT. Cross-sectional data of 3367 state-government employees from Tasmania, Australia, were collected in 2010. Overall, respondents chose HCTs relevant to their health behaviors. The most frequently selected HCTs were PA, diet, and weight. The majority was in the "action" stage for their HCT, except for those nominating smoking cessation, changes to work characteristics, and moderating alcohol intake. Employee perceptions of their own health needs broadly corresponded to their health-related behaviors, weight status, and stress. Workplace health facilitators should be prepared for variable uptake on smoking cessation programs. Physical activity interventions are likely well received, irrespective of risk-related lifestyle factors.

"Last season on Being Human..." "Once a month, I'm a killer." "I've been trying to be clean for a decade." " Are you serious?" " About what?" "Being normal?" "I'm Sally." "Hi!" "A door?" "The portal that takes you beyond when it's time to mosey." "Don't miss it 'cause of me." "I'm stuck here." " This is your secret?" " Aaah!" "Josh?" "There's no cure." "And just a scratch was enough." "You are the leader now." "She wants to meet you." "So I guess we should've started slower with the whole being-normal thing, huh?" "* I've been waiting *" "* Waiting and wishing*" "* Lying and cheating *" "* Hoping you'll come alive for me tonight, babe *" "* Hope I come alive *" "Aw!" "I can't do this, man!" "No, you can." "It just takes a little getting use to." "So much killing." "With the cleanup crews and the system, we are all at risk of exposure." "What do you want us to do?" "We're feeling all alone." "I'm trying to help with that." "Really?" "'Cause none of us know what the hell we're doing out here." "Tommy, I've only been at this a few weeks!" "Nobody comes into this world alone." "That's what Bishop told us, right before you killed him." "Oh, Aidan, we were promised a new kind of family." "I left my wife, my kids for what?" "For this?" "You gotta step up, man." "You gotta step up and make this right." "I can get you more of this." "Look, you know where I work, right?" " Yeah." " Come by tomorrow." "I'll see what I can do." "Who's she?" "What?" "I keep hearing:" ""She's coming." ""She's coming."" "What the hell does that mean?" "I'll tell you tomorrow." ""Freedom" is just pretty way of saying that you've gone off the grid." "For better or for worse, you're out of options." "But we call it "Freedom" We write songs about it." "You probably crank them in your car, and never thought about it much." "Some people think it's exhilarating not having your future mapped out." "Others start to drown in all that nothing." "Maybe you'll enjoy for a moment the purity of doing what you want, when you want." "Beer for breakfast, sex in the afternoon." "But obligations sneak up... duty, moral code." "Some of us are wired to put ourselves back into cages." "Freedom is just that moment of calm before the dread sets in." "Aidan, we need blood." "We need the blood." "Aidan, please!" "I need my blood." "It's OK." "Just don't..." "Because no matter what you freed yourself from, you only get so far down the open road, car windows down, music blasting, before you're forced to take a turn, make a choice and sentence yourself to the next adventure." "Hmm..." "Hmm..." "You OK?" "Yeah, I just..." "Yeah, right, and the doctor said..." "She said 4 weeks." "Four weeks." "And yeah, it's..." "It's been about a month since that night... so I should be fine." "Oh, I missed your skin." "Uh..." "You can't miss that." "I missed all of it." "You are a morning person!" "Yeah, yeah." "I know." "I'm..." "I'm sorry." "It's the wolf." "It's, um..." "If I may refer to it in the 3rd person." "I just get a little..." "So I see." "Yeah." "What else do you feel?" "What's it like?" "Nora, you saw it." "Yeah, I know, I know, but we haven't talked about it." "We haven't talked about any of it." "OK, um..." "The couple days before, uh... your senses get heightened." "It's like after a rainstorm." "The wind changes direction and you notice things." "And taste is like..." "First I want a burger and then I'm like:" ""Screw the frickin' burger." ""I want a mound of raw steak."" "Not a mound, but..." "You don't have to do this." "You don't have to take all this on right now." "I mean, the whole point of this was not to do this." "The point of what?" "An apartment." "A job, um... a girlfriend who's too good for me." "Normalcy." "That's the whole point." "Sally, how 'bout I..." " I can do it!" " Or your way's good." "Ah!" "How important is it really that the blood is warm?" "He had a rough night." "I'll just..." "So, there were an unusual amount of tweaky-looking vampires scuffling around the doorstep last night." "And I took care of them." "It's temporary." "A month is a little long to be temporary." "Do you want coffee?" "I can pour coffee." "I do want coffee, Sally, but I want it in my mug." "I'm sorry, sorry." "So, I thought you killing Bishop was wiping the slate clean." "Yeah, well, because I killed Bishop, it's my responsibility to control the chaos." "Because..." "What?" "You want one of the doorstep tweakers doing it?" "I want to contain this, survive this quietly, and the least I can do is set an example of what I do believe which is normalcy, civility, living our lives without taking others'." "Sorry." "Nice work." "Look, Josh, Mother's coming to meet with me." "So, that is happening?" "Because it's been weeks since we heard anything, and I was just thinking maybe she was on a cruise in, like, Alaska." "It's really nice this time of year." "When you live forever, a few weeks is nothing." "Look, when Mother gets here, she will determine the proper order and that's that and not even the council can go against her word." "It's all good!" "If there could be a lot less" ""Mother will determine the proper blah, blah, blah"" "and... and floating, broken coffee mugs when Nora comes down here, that would be awesome." "OK, come one." "I mean, she knows I'm here." "She saw Aidan not die." "She saw you wolf out." "You know, in the words of Don Aidan, it's all good." "No, it's not." "Is Sally here?" "She is." "What's that?" "I found it in the bathroom trash can." "Her high-school reunion is today." "Does she even know?" "Yes, she knows." "She found it in the mail, and expended a lot of energy trying to hide it in the tras." "But thanks, Nora!" "So you're not going?" "What's the point?" " Oh!" " Yeah." "She's wondering why she should go." "Oh!" "You have to go." "It's like going to your own funeral, only way... better." "OK, reunions are all about proving your success." "Right?" "What am I proving?" "That I can sometimes hold a spoon?" "I can't." "I can't." "Too depressing." "Can't do it." "She has very valid reservations." "Well, she..." "You will only be seen in the best light." "Everyone there will be talking about you." ""She was so young, so beautiful."" "Oh, come on." "It's true." "Well, I gotta go look at my hair." "You can't change your hair." "I can still look at it!" "Sally, I promise you that you're way better off than everyone who's gonna be starving themselves this week." "Am I right, girlfriend?" "She's gone, isn't she?" "Yeah." "She's considering her hair." "Right." "Hey, so, we should get to work." "Nora, you wanna..." "I'm not on till 1:00." "That's right." "Bye." "Bye." "See you before I turn." "I'll see you soon." "OK, Mr. Sims, showtime!" "The changing of the linens." "Mr. Sims?" "Oh my god!" "I know you." "You live with Aidan." "You should probably page him, stat." "Oh, would you mind..." "Uh, could you..." "Standing watch?" "Be your lookout?" "I don't know, sure!" "Why would I..." "Why would I mind?" "I woke up this morning with such a void in my life," "I am "jonesing" to be an accessory to murder." "Let's do this." "I'm so sorry." "I came to meet you." "I was walking down the hall." "It's just..." "It's this place." "It's everywhere." "No, it's OK." "I know." "You idiot!" "I was trying to help you." "I was starving!" "I couldn't wait for that bag piss you call food!" "What's the point of staying in the shadows and keeping a low profile when she's just gonna kill us anyway?" "What?" ""The culling." That's what they're calling it." "Bishop built up his illegal army and Mother's just gonna kill us all to protect the other families or some other vampire political crap." "Listen, I cannot die again." "You hear me?" "I can't." "And you're not gonna." "Look, I told you..." "I'm doing everything that I can." "Adele, come here!" "Every time I start getting weepy," "I remember Van Hogan "pantsing" me in the cafeteria." "Yeah, and then I remember high school sucked." "Stevie Atkins?" "Oh my god!" "Ha!" "I thought..." "I thought you were..." "You thought I was dead?" "Good, we're gonna go with that." "You know what I mean." "I gotta say, I'm surprised you're haunting high school." "Why?" "'Cause I killed myself to get out of here?" " Yes." " It's compulsively interesting." "And plus, they totally glamourize my suicide." "It's a great message for the kids." "Right, well, how pissed are you that I'm stealing the spotlight this year?" "Murdered, my friend, by my fiancé." " Wow, that..." "That's cold." " Mm-hmm." "You know who bit it a few months ago?" " Who?" " Diane Alcott." "Hmm!" "What, she like, uh, she get crushed under the weight of her pageant tiara?" "Did her lustrous hair smother her in her sleep?" "Did her boobs creep up and, you know, punch her in the face or something, hmm?" "Malaria." "She was a Goodwill Ambassador in Africa." "Malaria." "Well, that's just stupid." "They have drugs for that." "Look, you don't have to do this." "You don't have to do this." "Excuse me." "I thought you said that there were people that were vampires that you could call who clean stuff like this up, like the Merry Maids who help make gunk disappear." "Yeah." "There are." "There were, but when I killed Bishop, the institutions, the levers that he used to control, this is all fractured now and now it's all on me." "I didn't ask for it." "I don't want it, but there it is." "I have to make it disappear." "But I have Nora." "And med school." "I know." "It's just too many things" "I'm trying to accomplish that don't involve..." " I know." "It's OK." "Wow, Brian, what happened to you?" "Here's the problem with reunions:" "You have the girls who look better." "You have the guys who look worse, but the girls remember them as they used to be." "Next, she's calling her friend to pick her up in front of his hotel after they've just had awkward, half-chub reunion sex, and all does not end well." "You know, you are far too wise to look this young." " Oh, here we go." " Ah!" "Stevie!" "Classic." "Sally!" "She's so beautiful!" "I miss her so much." "Me too." "Oh, come on." "Bitter much?" "Please." "I just never saw the point in Diane Alcott." "Yeah, what is the point in a body like that anyway?" "Honestly!" "You've liked her?" "Isn't it sweet?" "It's amazing how you can touch someone's life without ever really knowing them, right?" "Yeah..." "Did you guys go here too?" "We were in your class." "But I killed myself in junior year, so it's cool if you don't re... remember me." "Junior year was pretty stressful." "Well, I'm Diane." "Hegeman." "I wasn't expecting you." "Of course we're all here." "The council?" "When you told me that she wanted to see me," "I guess I was expecting more of a dialogue, a discussion, not a spectacle." "Validation." "She's here to give you Boston." "This is the traditional way." "I just..." "Things haven't exactly gone smoothly over the last month." "I have questions." "No, you don't." "You have only answers." "When she asks you to accept, you say yes." "That is all you say." "That is all that is ever said." "Tradition, Aidan." "My condolences." "Bishop." "I know you two were close." "Thank you." "Do you speak on behalf of the council, Hegeman?" "Only to reiterate that Aidan has our full backing." "Along with yours, it would, we believe, confer upon him the upmost legitimacy in Boston." "Hmm..." "And Hegeman..." "Please, sit." "Those that Bishop turned, the illegitimate ones, what is to become of them?" "All that they deserve, Mother." "They were turned in blatant violation of our agreement." "Naturally, they will be culled." "And you, Aidan." "Do you feel the same about Bishop's orphans?" "I think..." "I think many are confused, scared, not sure what they did to be singled out." "Your recommendation?" "Mercy." "We must be careful not to paint them with the same brush that we've painted Bishop with." "It was his ambition that was the enemy, not those he turned, many of which could prove extremely useful." "No." "They'll be culled." "We've gathered here to confirm the best vampire to lead Boston." "And so we shall." "That person is my daughter." "And she's..." "Is she well?" "Very." "I think what he means is..." "Are you sure it wouldn't be too much for her, asking her to return to this place?" "Boston?" "Here, this hotel." "One wonders if the memories of what she did... might be too overwhelming." "This is exactly where she needs to be." "And she will have the best of stewards to guide her." "Aidan." "Excuse me?" "You will be my daughter's second." "You will answer her every question, her every need." "You will stand behind her as she brings Boston fully under her control." "In return," "I will overlook your peccadilloes, your heresy, and upon her success," "I would be willing to grant you true release from all this." "Is that something that would interest you?" "Freedom?" "Is that your secret?" "I'm sorry?" "You're skinny because you eat raw meat?" "What the hell diet is that?" "Um, it's actually a "paleo" thing." "Have you heard of those guys?" "You know, you eat like cavemen, run like you're being chased by a dinosaur." "Yeah, it's... it's a lot of raw meat." "And, uh, bamboo..." "I know I'm a nurse, but wouldn't diet pills be so much easier?" "I know." "This is disgusting." "Can I have a chip?" "Ha!" "Thank God!" "You're human." "Yeah." "Mmm!" "Do you ever regret ending it before you knew what was gonna happen?" "You were 16." "I didn't really think it through." "I mean, I did, enough to get the pills, but..." "You know, part of me always thought, you know:" ""Someone's gonna stop me." "This can't actually work."" "Oh, Stevie." "And what about your door?" "Moving on?" "I mean, that's something to look forward to." "Yeah, maybe for you." "It's kind of a known known, if you off yourself, no door." "Tell me about it." "I saw my door." "Missed it." "What happened?" "You know, life, afterlife..." "Yeah." "You ever try sleeping, just block it out?" "Ha!" "I wish." "Wait..." "Can we even do that?" "We can if we want to." "I mean, it just kind of helps speed up the endless nothing, and I actually dream, and the dreams are great." "It's kind of like living, except everything turns out right." "Things can still turn out right for you." "Trying to get a party started?" "No, not me." "Diane Alcott." "Hey." "Hi." "So..." "What time do you actually... turn?" "Why are you asking?" "Well, I wanna pick you up." "I'll take you to the woods." "It's good, right?" "That I should be with you?" "So what time?" "Yeah, let's not do that." "Excuse me?" "I just don't think it's, um..." "I've seen it!" "Wasn't that what you were scared of?" "It's out there, Josh." "We're past that." "We're not past it." "It's all we ever talk about." "No, actually, we've talked about anything else for the last 30 days." "Only this morning did I start asking you questions, really, finally, about this." "Yeah, and you saw it." "You've seen it." "So what else do you want to know?" "I wanna know how you feel, if you're scared, if..." "I don't know." "If you like it." "Of course I don't like it." "I just wanna know you." "You do!" "I'm sorry." "You know the version of me that I wanted you to know." "And now, unfortunately, you know the rest." "I'm just gonna go alone tonight." "OK?" "We can talk about all this later." "Sure." "Let's put it off for another month." "Nora, please." "Nora!" "We've known each other far too long, Hegeman." "Far too long." "Maybe you can tell me, then, why is it the young never seem to want what we want?" "Your daughter will succeed, Mother, in time." "You blame yourself far too much for her shortcomings." "You're wrong." "It's always the mother's fault." "A vampire whose only wish is to forsake all vampires." "How did the Aidan I knew 80 years ago become that... a heretic?" "He cannot fail." "My daughter cannot fail." "Not again." "We must help him, Hegeman, you and I." "No folly, no distractions, no wolf." "You've been a little bit hard on me." "Really?" "Yeah, a little bit." "Well..." "OK, not a ton." "Just a pinch." "We made a deal." "I know, and it is the most important thing in my life." "She's asked me to help lead Boston." "Mother?" "Am I supposed to be clutching my pearls in shock?" "'Cause I'm not shocked." "I know." "I'm just telling you, because... in order to be free, really and truly free," "I'm gonna have to do this." "There's a good chance that I will become... something... that you would not recognize." "And when..." "And if that happens..." "Josh, I'm gonna need you to somehow remind me... what we started here." "And I always wanted to tell you when we were both back in high school and I..." "I guess it just never really slipped out, you know." "And now you're here and I do wanna tell you, and as I said, you know, we're here and..." "Hey!" "Oh!" "Hi!" "Hi!" "I have news for you." "We're dead." "You're dead, and that pretty much levels the playing field." "So don't write off a guy like Stevie just because he's not cool enough." "Nobody's watching." "You can do whatever you want!" "If I can do whatever I want, then why are you forcing me on Suicide Stevie?" "I'm standing right here, hearing everything." "You haven't been dead that long, so maybe you haven't gotten to that soul-searching part yet, so why don't I save you some time?" "You were shallow." "You were conceited." "You made the entire cafeteria a killing field." "God, Stevie killed himself and you don't even remember him?" "Really, Diane?" "'Cause I remember you planning a memorial just to get votes for prom queen." "Seriously?" "Life is easy for people like you." "Death shouldn't be." "Wow!" "Yeah." "You're right." "I was a terrible person." "OK..." "I'm sorry I didn't remember you." "The truth is, I was always jealous of girls like you." "When I died, for my last split-second." "I was thinking:" ""Thank God!"" "I can finally just relax!" "I've been sucking my stomach in for 15 years." "Oh!" "Thank you!" "Was that there before?" "And there's your door." "My what?" "She doesn't even know what it is!" "Come on." "The car's up front." "Show yourselves." "What the hell are you doing, Tommy?" "We just need to talk to her." "A few seconds, Mother." "Please, that's all we need." "Not like this." "Not here." "We didn't do anything, Aidan." "She can't just slaughter us like cattle." "I told you I'd deal with it." "Then deal with it!" "Join us... and we'll all be free." "Don't do this." "Aaah!" "Aidan..." "Go!" "Come on." "Aaah!" "Aaah!" "Thanks for letting me do this." "Sure." "When I was a freshman in college," "I woke up in some theater major's apartment with my clothes across the room, my hair still smelling like vomit." "I'd puked in front of the entire party, repeatedly, while reciting "Stopping By the Woods on a Snowy Evening"" "just to prove that I wasn't drunk." "The point is once you've picked your naked way across the theater geek's living room in the cold light of day, after a vodka binge..." "It's not the same, Nora." "No, it's not the same thing." "But the reason that I want to be here for you, is that I don't want you to feel alone in this." "You want to hold my hair back while I vomit." "Yes." "Yeah, essentially." "I love you." "Now, seriously, please get as far away from me as possible." "* Hold me *" "* Memory *" "* You see *" "Guys?" "* Where I'm going *" "Capital." "* Give back all I had before *" "* Moving *" "* Escaping *" "* Growing *" "* Entropy that is *" "* Oh *" "* Oh *" "* Eclipsing into *" "* All that I can't ignore *" "Whoa." "Guys, get your friggin' asses down here!" "This is incredible!" "Hello?" "Aidan!" "Josh!" "Family meeting!" "Now, please!" "Hello!" "Who are you?" "What do you want?" "Oh!" "Oh!" "My little girl." "Oh, thank you, thank you." "Thank you." "Oh!" "No!" "No, Josh!" "Josh!" "Josh!" "Josh!" "Josh!" "Nora." "Josh!" "Nora!" "Aaah!"

A need exists for a substantially global radio telecommunications system that can provide communication services to substantially any point on or near the surface of the earth. For such a system to achieve widespread acceptance, it should be capable of operating with portable subscriber units. In order for subscriber units to have acceptable portability, they should be capable of low power battery operation, and they should be capable of transmitting and receiving electromagnetic signals through a relatively small antenna. Such a global radio telecommunications system and other radio telecommunications systems may desire to know the locations of the subscriber units. A radio telecommunications system may then qualify the communication services offered to subscriber units depending upon subscriber unit locations. For example, services may be denied within geopolitical jurisdictions where the system has not received permission to operate from governmental licensing agencies. Moreover, the system may be responsible for billing in connection with the use of communication services, and the rates charged for such services may vary from location to location due to tariffs and the like. Likewise, different portions of the electromagnetic spectrum may be used for communications depending upon where a subscriber unit is located. Accordingly, it would be desirable to configure the system so that the locations of subscriber units may be determined and so that information describing locations may be transmitted to controllers which are responsible for making decisions regarding the granting or denying of communication services, billing rates, and the like. Many prior art location determination systems are known, such as Global Positioning System (GPS), GLONASS, Loran, and the like. While subscriber units could be configured to incorporate components which take advantage of such location determination systems, these components would substantially increase costs of the subscriber units. Moreover, relying on such known location determination systems could reduce reliability of the radio telecommunications system by introducing reliance upon an external system. The techniques used by such prior art systems to determine location could potentially be incorporated into a radio telecommunications system, but the introduction of such techniques could seriously degrade communication services. For example, most prior art location systems require the use of two or more transmitters or receivers ("locators") that are located at distant positions and that are capable of transmitting or receiving signals to or from a locatable unit whose location is to be determined. Furthermore, some prior art location systems require the use of coherent transceiver designs. The requirement for two or more locators to be within view over the entire globe makes this approach economically undesirable. While this requirement might be met by placing satellite locators in high or geosynchronous orbits around the earth, higher orbits place satellites further away from locatable subscriber units on the earth. This larger distance causes the subscriber units to consume excessive power or incorporate massive antennas just to participate in communication services. Moreover, higher orbits require increased spectrum allocation to carry a given amount of communications because the allocated spectrum may be reused less frequently in a given area. The requirement for a coherent transceiver design is also economically undesirable. Unless satellite locators orbit the earth in very high orbits, such satellite locators move relative to a point on the surface of the earth. Unless locators are substantially motionless relative to locatable units, significant amounts of Doppler are present. This Doppler constantly changes. Likewise, signal propagation delay between the satellites and subscriber units constantly changes. A coherent transceiver design which operates in spite of these extreme and changing signal parameters is undesirably complex and experiences an undesirably low reliability and undesirably high manufacturing and sales costs.

Flies, worms and the Free Radical Theory of ageing. Drosophila and Caenorhabditis elegans have provided the largest body of evidence addressing the Free Radical Theory of ageing, however the evidence has not been unequivocally supportive. Oxidative damage to DNA is probably not a major contributor, damage to lipids is assuming greater importance and damage to proteins probably the source of pathology. On balance the evidence does not support a primary role of oxidative damage in ageing in C. elegans, perhaps because of its particular energy metabolic and stress resistance profile. Evidence is more numerous, varied and consistent and hence more compelling for Drosophila, although not conclusive. However there is good evidence for a role of oxidative damage in later life pathology. Future work should: 1/ make more use of protein oxidative damage measurements; 2/ use inducible transgenic systems or pharmacotherapy to ensure genetic equivalence of controls and avoid confounding effects during development; 3/ to try to delay ageing, target interventions which reduce and/or repair protein oxidative damage.

Morbidity in users of family health teams in the northeast of Minas Gerais based on the International Classification of Primary Care. This study aimed to characterize the profile of morbidity among users of family health teams in the northeastern macroregion of Minas Gerais, Brazil. This is a cross-sectional population-based study, developed with the teams of the Family Health Strategy (FHS). It was conducted by data collection, using semi-structured questionnaires with specific instruments adjusted for three categories of professional teams of the FHS: physicians, nurses and community health agents (CHA). We used the International Classification of Primary Care, second edition (ICPC-2) to encode morbidity. Information was collected from 17,988 people, and 10,855 (60.3%) were females; 1,662 (9.2%) questionnaires were related to care by the physician; 2,530 (14.1%) were related to care by nurses and 13,796 (76.7%) corresponded to visits by and meetings with the CHA. The main health problems were: circulatory diseases (especially hypertension), musculoskeletal problems (especially back pain) and diseases of the digestive tract (especially intestinal parasites), which accounted for more than 40% of the medical consultations. Nonspecific complaints and visits related to women's health were the most prevalent in the care by nurses. In meetings with CHA, complaints about respiratory, musculoskeletal and cardiovascular diseases were the most pointed. The morbidity profile observed does not differ substantially from the results of other studies. Small differences can be attributed to regional particularities.

"This way!" " There!" " Where?" "Next to the further beech tree!" "Get Down." "THE RED BARON" "Are you out of your bloody mind?" "Yes sir." "You risk the squadron planes to attend an enemy funeral?" "Yes sir!" "Lehmann and Sternberg knew him sir, Captain Winston Clyde Walker." "The chap in the coffin I meant, sir." "Yes!" "I mean, sir..." "My uncle, the Duke of Westchester is his mother's brother-in-law." "Lehmann and I, we went to school with him." "Eton, sir." "You're talking about a British pilot, for heaven sake." "One of the best in the Royal Flying Corp." "It's a pity that he's not with us anymore, sir." "Oh, what the hell!" "Dismissed!" "I've heard you got yourself some holes, while paying your condolences, Richthofen." "Ah, I love these small gossipy airfields, Kielmeyer." " Anyone wants a cigarette?" " French?" " De rien." " Merci." "Richthofen brought down a two-seater." "I supposed that's to make up for ignoring my orders." "No... just adding to my score." "I have just got a report, a British RE8 crashed 12 km from here." "My utmost respect, Baron." "Let's go find your plane, let's get your kill confirm, you bastards." "Help me, come on... help me!" "Careful... alright." "One, two, three..." "I said careful..." "Hurry up... he's bloody heavy." "He's losing a lot of blood." "Take these off." "You'll be alright, you'll be alright!" "You can take him." "Pick him up!" "Thank you!" "You saved this man life." "No." "I shot him down." "You're down, Sternberg." "Oh no." "You attacked single seater DH2 from above towards the..." "Listen Sterni, if the attacker has a rotary engine then...." "What is a rotary engine?" "Oh Lieutenant Sternberg..." "Oh... hello!" "Hey..." "Well obviously she prefers men like me, Voss!" "Men like who?" " Moses, Freud..." " Better get ourselves circumcised, Voss." "Good evening!" " Bonjour lieutenant." " Hello, Monique." "Hey, not so fast." "Hey Manfred..." "look, she looks like your little nurse at least from behind." "My little..." "Voss." "Oh la la!" "I'm sorry, sir." "What are you doing here?" "Have a seat, have a drink on us." "I thought you chaps just wanted to have some cocktails." "Sit down and have a drink with us." "Here!" "I'm married you know..." "So am I!" "I mean, almost... at least." "... we need a bucket of water." "The driver says the engine is overheated." " Lieutenant." " The name is von Richthofen." "Pleased to meet you again, Mademoiselle." " I know your name." " Well?" "The pilot you shot down told me who you were." "Did he survived?" "Do you really care or are you just curious?" "The latter." "At least you are honest." "It's a start, isn't it?" "Can you be caring without being curious in the first place?" "So... what's your name?" "His name is Captain Roy Brown." "And he's alive, no thanks to you." "He told me you're a supreme professional" "Well done!" "and a tricky rascal." "Well..." "Look..." "Tell him that I'm honor by his compliments and hope I never have to meet him in the skies again." "He might get the better of me." "And I might not be lucky enough to have such a gorgeous attendant." "Unbelievable." "Enjoy your evening." "Do you happen to know what became of my scarf?" "I'll have it send to you." "No... keep it." "It will bring you luck!" "The French have sent their condolences and claimed the kill." "The service for Kielmeyer will be held at 1600 hours." "The pilot who lead the attack against us 4 days ago, it was Hawker." "What?" "Major Lanoe Hawker?" "The very man." "I saw his face... full beard." "And the Grim Reaper painted on his fuselage." "It's their top man." "Oh shut up... scary fellow." "He downs 9 of us." "When they used to fly the unarmed reconnaissance, he latched a one shot hunting rifle to his fuselage." "We almost touched wings." "Had a hard times to stay out of his ways." "When you got that close, why didn't you attack?" "I only attack if I can win." "How badly do you want the Pour le Merite?" "I would kill for it." "I just received a cable from Supreme headquarters, ... and guess what?" "They badly wants to give it to you." "Why don't they then?" "You know the rules." "And not even Imperial command would bend them for you, so hurry up and shoot down a captured balloon." "I hunt aeroplanes, sir!" "Not objects that cannot move." "You are not a hunter lieutenant, you are a soldier and you will follow orders especially when it comes straight from General von Hoeppler." "What if I shoot down Hawker?" "Stay away from Hawker." "You are no match for him." "Let me through." "Has anybody got a spanner?" "I don't believe it." "So you finally did it!" "You bagged yourself a legend." "That made you a legend too!" "Have one, my mother made them." "Oswald Boelcke... first of the Aces." "They are desperate to find someone to fill the gap he left." "You know what he once said to me when I asked how he managed his business." ""Well, it's quite simple I fly close to my man aim well... .. and then of course he falls down."" "Sterni and I are off to Arras, why don't you join us for a drink?" "Not tonight!" "You could look for the little nurse." "I mean the sooner you have her, the sooner you get her out of your system." "Can't have ties that involved, can we?" "Werner?" "Hmm?" "I will filled the gap!" "I will be the first of the Aces." "Stop!" "There you go." "I'm starving." "Yeah, me too." "Prussians don't whine, gentlemen." "Let's go." "Go and find us some breakfast." "At ease, gentlemen." "L'ordre Pour Le Merite..." "Where is it..." "Prussia's highest bravery award." "A year ago Boelcke was the first pilot to ever received it." "A lot has changed since right, Baron?" "Indeed... sir!" "He only had to down 8 to get it." "I shot down twice as many." "An exception for you has already been made, Richthofen." "You... still owe us that balloon, don't you?" "However having shot down the enemy's best" ""the notorious Captain Hawker"" "you are now Germany's premier air ace." "You'll take over command of 11th Fighter wing." " Come!" " Excellent, sir." "Have a look at this." "Here in the east, the Tsar's armies are the least of our problems, gentlemen." "He'll soon have a revolution on his hands." "Amusing, isn't it?" "Lenin and his communists helping the German emperor..." "The Western front is where the danger lies." "The British 1st and 3rd armies are probing our lines with everything they've got." "And they have got plenty." "I must drive them back, inch by inch and day by day," "without Lenin's help." "Richthofen, you'll be station at LaBrayelles," "Northwest of Douai... here!" "Right in the middle." "Sir?" "Yes?" "Isn't the middle supposed to be closer to Paris by now, general?" "I mean, didn't you said that we'll be there in 10 days 2 months ago?" "Manfred!" "High command has given you a tremendous responsibility, young man... going far beyond this medal." "You're promoted to lead not only the men of our futures placed under your command, you've been chosen as a leader of all fighting men." "Symbol of courage, bravery and overtness, determination." "A symbol of Germany's superiority." "Pilots are like Gods, Richthofen." "When we lost Boelcke, our troops lost a hero." "And if our enemy can killed God, what chance... does the poor farmers dug deep into the trenches thinks he has, hmm?" "Gods don't die." "Do you understand it?" "Yes sir." "Fine!" "You're dismissed, gentlemen." "Sir!" "Yes?" "Asked!" "Any chance of some croissants and coffee?" "Here you are!" "Good morning mother." "I take it you've a comfortable trip." "When you're finally rid yourself of this worn out jacket, Manfred?" " Where is it?" " Cousin... brother!" "You bastard!" "May I see it?" "It's in there!" "Here he is, my famous brother." "And he is still wearing this old jacket of his." "I've already told him..." "Stop making a fuss about my jacket!" "Give me a hug." " I still think that the jacket..." " Mom!" "Good to have you home, son." " Slow down..." "low torque." " I know!" "Keep your rudder straight." " Stop now." "Let me..." " Close up..." "I said straight..." "I said straight!" " You're not going straight." " I can't concentrate." "Everybody comes to honor our son, and all they do is played with that plane." "... like little boys." "As if my brothers would ever grow up." " Handsome little boys." " Watch out!" "I'm taking a left now." "Slow down!" "Let them enjoy their youth, whilst they can." "Watch out!" "Watch the hay stack!" "You said you could fly a plane." "I can't!" "Wait till I'm sitting in a real plane." "I'll beat your score." "Hey!" "Let go of me!" "Keep the sun on your back." "Don't fire too soon." "It just warn your opponents, it has no other effects." "The best range for shooting is 50 meters, not more." "But remember, our tasks is to bring down aeroplanes, not men." "So stop firing when your opponent's falling." "Gentlemen, we are sportsmen... not butchers." " Merci." " De rien." "Gentlemen!" "I'd like you to meet my chief mechanic..." "Sergeant Reuber." "Dismissed!" "Sir!" "Stop clicking your heels, Wentzke." "Yes sir!" " Hello!" " Oh, I almost forgot... if each of you hasn't shot down at least one in the next 4 weeks, you're fired." "Lieutenant!" "This is a hospital, who do you think you are?" "I'm sorry." "You knew him well?" "I still don't know your name..." "Kate Otersdorf." "Un nom allemand, a german name?" "My father was German, my mother is Belgian." "I see." "I love these french cigarettes." "You are a very beautiful woman." "I was hoping to see you again." "And I thought maybe wearing my scarf." "I will get it for you." "I couldn't get all the stains out." "Mademoiselle!" "Have I done something wrong?" "Am I not worth an answer or is it just you hate all men?" "Hate?" "I don't hate you." "Hate is men's domain." "But you are angry, aren't you?" "There is another man's blood on it." "And you do not seems to care." "Men like you scared me because" "I do not understand why you do what you do." "And being scared makes me angry." "And now please, leave me alone." "Wait, WAIT!" "Imagined you were out there..." "Like a hawk." "Looking down..." "The wind blows around you." "The smell of the engine, draft from the propeller." "Out there you can just not fall, you can climb, turn, spin..." "Freedom!" "That's what men always dreamt of." "I've dreamt of it since I was a little boy." "But the best part, is the chase!" "The fights..." "The hunt!" "It's like a match." "A joust, just like sports." "Tennis does not kill you." "It's childish dreams that got your friends killed." "No, I don't hate you, Baron." "I pity you." "Gentlemen, please!" "It shouldn't be that hard... to paint a plane, should it?" "Just do it!" "Reuber!" "Manfred..." "What's wrong with you?" "What is this crazy paint job all about?" "Honestly, you know damn well OCA will crucify you for this!" "I don't care about what the 'Officers in Charge of Aviation' think of this and you better not question my orders." "I just think you're making a mistake." "They will spot you from a long way off." "We completely lose the advantage of surprise." "I don't want them to be surprise." "I want them to be scared." "Lieutenant Kurt Wolff reporting for duty, sir." "Planning to take a nap up there, lieutenant?" "Never fly without it, sir!" "You know, for luck!" "Superstitious huh!" "Like me..." "My mother keeps ordering new coats from our tailor, I've never pick them up." "See you around." "Sir!" "The general!" "General von Hoeppner!" "Over here, sir!" "You've become quite a celebrity, Baron." "You are making headlines." "The emperor himself mentioned your name after hearing about your 29th victory." "So..." "I brought a little surprise for you..." "Didn't they runs out of medals to give me?" "Well, it isn't exactly a medal." "Sir..." "It wasn't my idea." "We just thought it would be good propaganda." ""The Richthofen Brothers flying together."" "Welcome." "Your brother is a nice chap." "He really has the spirit our Fatherland needs right now." "So tell me... they comes out with this strange names for you..." ""Le Diable Rouge"" "or "The Red Baron"" "Why is that?" "I see." "So much about army rules and regulations." "Interesting!" "Very interesting!" "Tried to keep the sun on your back..." "Watch out for the winds." "And never forget, a pilot greatest virtue is to know when to run." "What... what this a joke?" "Just do what he tells you to do, Lothar." "Run away from a fight?" "Yes!" " If you cannot win, you fly away!" " Fast!" "It's a thin line between cowardice and cleverness." "It's true." "Alright!" "Morning, gentlemen." "That's a great idea." "I already heard rumours that the French thinks this paint is bulletproof." "I wouldn't take this with me." "It could get on the way up there." "This looks much better." "The crop stays here." " Scattered them up, didn't we?" " Yeah, it was getting busy up there." "Damn French knows how to protect their observation balloons." "I'm alright." "It was fun, wasn't it?" "Can I stay at your cottage tonight?" " Already feeling lonely?" " Yeah." "Did you have him transfer?" "Who?" "Your brother, Lothar." "Where is he?" "Did you see him?" "He was right behind me." "You better keep an eye on your little brother." "He has a hell of a dangerous attitude." "Oh for God sake." "Let the poor fellow land." "What is he doing?" "God... for Christ sake, Lothar!" "You shot this poor bastard to pieces." "You think this makes our father proud?" "He lost his hearing saving a wounded enemy." "So now you want to win a war without killing anyone, huh?" "I've watched you and Voss, and I don't like what I see." "You are all..." "you are all brilliant pilots, but you've got the wrong attitude." "This business of painting a war plane red..." "Stop dreaming!" "This is just not a polo game." "We are not boys anymore, we're grown men fighting a bloody war." "I'm quite aware of that." "I'm quite aware of that!" "But still, we can fight it with grace." "What?" "You were listening?" "The Marseilles heard you in Paris." " ... and Berlin." " Come on, he is just ambitious." "Well, have him contained then." "I for one, I don't want to get kill because of his ambitions." "And I hate to see you get kill either." "Morning my dear Hindenburg, and my dear friend von Hoeppner." "Welcome to Berlin, gentlemen." "The young man already seems to be more famous than what was his name?" " Oswald Boelcke, your Majesty." " Yes... yes!" "We need men like him." "I supposed... we'll have to give you another promotion, Richthofen." "You are a real hero." "I take it the ladies're all over you." "There aren't many ladies at 10,000 feet, your Majesty." "Corp, attention!" "Well, are you ready, gentlemen?" "Move on!" "Don't fall asleep." "Move on." "Captain!" "What shall we do, sir?" "I could run them over." "Put the pistol away." "What did he say?" "He wants my Captain's autograph." "Merci!" "Ready!" "Go!" " Ready!" " Go!" "How did you know?" "I saw you lose it." "Good morning, gentlemen." "Bodenschatz!" "Welcome!" "My new adjutant." "Kurt Wolff!" " Welcome!" " I've heard a lot about you." "Thanks." "Orders, Sternberg, orders." "My new commanding officer is the man" "I commanded not so long ago." "So..." "I've heard you chaps ran into some massive Allied aerial activities?" "More than massive." "Germany produces 10 planes, they've got hunderds unloaded in the French coast." "Let them come." "We'll shoot them out of the skies by the hundreds." "Meet brother Lothar..." "No!" "Damn!" "You bastards!" "You fucking bastard!" "Damn gophers!" "You know it's pure luck I didn't ran into one of those damn holes myself." "Thank you for being so tactful." "After embarrassing me by landing safely with shredded fins." "I've come to have a look." "Sopwith, right?" "New, isn't it?" "It was..." "Captain Brown, Royal Academy Flying Corp." "Notorious Red Baron, I presume?" "Didn't I shoot you down a year ago?" "Indeed you did." "Why're you still flying around then?" "Well, your prison camps are quite fancy, however they don't have airfields." "Thanks for pulling me out of that wreck, for saving my life." "Pulling you from that wreck didn't save your live." "True." "Without her help I probably wouldn't have make it back into a plane." "She's sure is a great girl." "She nursed me for weeks." "Did you ever get back your scarf?" "What now?" "I guess we could try killing each other with our pistols." "Killing you would make me famous too." "Sorry, I didn't bring mine but you might want to button up your holster before you lose yours." "How long have you been station in Europe?" "Ever since Mother England called the kids for help." "Meaning us, the Commonwealth colonies." "You're right." "The entire war seems to be a family affair." "Family ties is what you aristocrats are all about." "Russian Tsar, the Royal familes in Britain," "France, Austria, Germany..." "Everyone is someone's nephew, uncle, brother." "Man, your love life sure knows them all borders." "But to protect those borders, we killed each other off anyway." "And we always managed to find good enough reasons, don't we?" "You didn't unsnapped that holster's guard because you were afraid of me, did you?" "You have damn good eyes." "You thought about killing me?" "Isn't killing each other the reason why we are here?" "Yes!" "Be seeing you." "Don't get me wrong but I hope not." "Yes!" "So long then." "Good luck." "Fucking family..." "Sooner or later this war will be over." "You should hook up with that nurse." "I think she's got the hot for you." "What makes you say that?" "She kept bitching about you for weeks." "Stop the truck!" "Stop the truck!" "There you are, we just found him." "Sterni!" "Get a doctor here." "He doesn't need a doctor, he needs a priest." "A rabbi." "Oh really?" "He's dead, Manfred." "I'm catching up, brother." "It's days now since we buried him." "Why is it you can't enjoy the fact that" "I've been promoted." "I'm your brother." "He was a friend of yours, I know." "But he was a fighter pilot too." "He knew the risks he took." "Every oath soldiers proudly take, but you are more than a soldier, you are a superior officer!" "You have a responsibility towards the men out there!" "Towards your country and your people." "You know what our father always said..." ""A leader cannot afford to mourn."" "You smell nice." "Much better than all the flowers." "You're still a little boy playing silly games." "You haven't changed." "I'm not so sure about that." "A while ago, I wouldn't have let myself got shot down." "Turn over." "So much for "Germany's bravest."" "I'm sick of men keeps bringing this report of our lack of success every damn day." "I'm just trying to fill your seat, sir." "You send out single squadron," "Doering." "They're in no position to battle successfully against enemy formations." "Captain Doering has his orders." "The 'Officer in Charge of Avaition' arranges us on a time table, sir." "They are a bunch of idiots." "Condemning us to routine burial flights." "We needs to be flexible." "Loose!" "Hit the enemy where he actually is." "The British and French moved their airbase wherever and whenever they like." "Yes!" "We hardly ever down their damn planes." "I order you, to ignore OCA orders." "Mademoiselle Otersdorf, what are you doing?" "Just following orders, Baron." "You were ordered to come with us?" "Yes." "Richthofen, nice to have you back, sir!" "Welcome back." "The red ones are the 11th wing." "The yellow 10th." "The Zebras..." "No: 6." "And the black ones No: 4." "You're looking at the most successful fighter squadron of the war." "And these men are the best pilots in the skies." "I thought it would never happen." "What?" "See you smile." "I thought you're not supposed to fly." "Your nurse is a very good looking girl." "I've got a hole in my head but I'm not blind." "I am already fit enough to punch you in the face." "What are you writing?" "A book." "About flying." "What are you reading?" "I never see you without a book." "No?" "Oscar Wilde!" "You ever read one?" "No..." "I cannot see any British literature in here." "Hmm!" "Try this!" "There must be" "Shakespeare in there somewhere..." "My father read his play's once." "'Lear...'" "'Comedy of Errors.'" "You might find a couple of songs too... and a lot of playing billards," "hunting, flying, riding... ahem... how to flirt." "A hole in the head makes reading someone mind pretty easy, Baron." "So..." "Just ask." "Would you..." "Would you join me for dinner?" "Yes." "So?" "Difference... from what I thought you would be." "Different?" "Your write, it's entertaining." "You thought it would be blunt, boring... and deadly serious." "No!" "But you write about war." "I thought there would fanaticism..." "patriotism." "Patriotism... hmm." ""...the virtue of the vicious."" "You did read Wilde." "Even a little Dante." "It's helpful right now." "To knows a little about infernos, isn't it?" "Dance with me." "No." "Better not... no." "I am an infernally miserable dancer." "Imagined you're flying..." "Great!" "To have a hole in my head." "Without it I wouldn't be sitting here next to you, would I?" "Mentzke... can you turn the car around?" "There are so many hospitals now they have to give them numbers." "This is No: 76." "There's 500 patients." "Most of these men will die." "Those that don't, will never walk again, see again, taste again... love again!" "No, it's not great to have a hole your head." "You're lucky to be still alive." "Being born of nobility, you've advantages these men here do not." "They don't have choices." "It's not a game." "This is the lowest we'll ever get." "It never gets darker." "Come in." "Can you give me something for my head?" "Go to the cellar." "Now!" "They fly at night?" "Get yourself a gas mask." "Do you fly at night?" "No, we don't!" "Here." "Find a save place." "Lights out!" "Everybody turns off the lights." "Give it to me." "It's OCA, sir." "This is Bodenschatz." "Turn off all the lights!" "Night bombers!" "Good morning captain!" "Four already passed and four more coming." "Just take it all, it could be worse, sir." "It's not as if they just happened to fly past, Doering." "They know about this field and there will be more than eight." "Lots more!" "Good morning." " Good morning." " Morning, sir!" "Wolff, you alright?" "I can't find my cap!" "All machine-gun posts are being manned." "There's nothing more we can do to protect the planes on the ground." "Mentzke, get my gear!" "Ready my plane." "You are injured, you cannot fly, Manfred." "I'm not going to be a sitting duck." "I've got wings." "You flew right in between them, are you out of your mind?" "Take me to her..." "You've to lay still." "Go and find her." "I just need to know if she's not hurt." "It looks plainer." "Fokker built this great new plane, as maneuverable as the devil." "They climb like monkeys." "I know you are angry with me." "I've been ordered back to the hospital." "I know." "I'm sorry about Kurt Wolff." "He was a charming young man." "He forgot his night cap, you know." "His lucky night cap." "Baron..." "Yes?" "Take me to dinner again with you sometime." "And promise to always wear this lucky jacket of yours." "We are not late, are we?" "No, we aren't." "Lavatory?" "Down the stairs to the right, sir." "Back in a minute." "Attention!" "Everything goes according to plan." " Yes!" " Very satisfactory, yes." "Oh." "Our famous flying ace visiting our frontlines!" "Thank you for answering my invitation." "Quite a dornier sight from down here, isn't it Richthofen." "Your Majesty..." "Your Majesty!" "Aha... the little brother." "You're looking desposed, my dear Baron." "Yes, your Majesty." "I'm fine." "I always am." "Sometimes even irritated, sir." "How can you be "irritably fine"?" "!" "It happens out here." "We kill a couple of men." "And while they fall down in flames, we feel just fine." "I find this irritating." "My soldiers, do not... kill people." "They simply destroyed the enemy." "Well, the effects seems to be the same." "Yes, Mentzke?" "You have a visitor, sir." "I thought you might want to celebrate." "They published your book!" "The whole of Europe is reading it." "So... how about dinner and then a dance?" "They shut down the "Metropole."" "Yes, I know." "A British bomb hit the kitchen." "Damn those English!" "They won't be happy till all of Europe foods is as horrible as theirs." "They don't want me to fly anymore." "They're doing everything they can to make me stay back on the ground." "Really?" "They want me to command the entire airforce, the emperor himself." "That's so wonderful!" "So many times I woke up in the middle of the night, and read... the lists of missing pilots." "It is so good to have you down here." "Safe!" "Good!" "Your dancing has improved." "I have a lot of times to do this anyway." " Good evening men." " Good evening sir." " Bloody freezing, huh?" " So true, sir." "A brand new Bentley." "Where did you get it?" "Bentleys don't fall out of the sky." "Trust me, I've to argue a little with the chap." "You always wanted to be first of the Aces." "Now they offer it to you and you hesistate." "Yes..." "I always wanted to be like him." "Werner..." "Could you ever give up flying?" "I don't think so." "But if you ask my advice... you should grabbed your chance." "You only want me to stop, so you can be first." "I'll let you find out." "Alright... alright." " I'll stopped..." " Good." "if you stop first." "I don't think so." "I am married to my plane." "This is how I spend my spare time." "These are fine planes you're building us, Fokker." " The best." " Yes, thank you." "And yet somehow our own pilots seem to think they can do better." "Oh well... we sometimes modified the plane a little." " Here and there." " Modifications is one thing, ...but replacing our engines with those from enemy planes..." " How did you hear of this?" " Early this morning we received a report of the recovery of a new triplane." "Well..." "The Brits were less than amused to find one of their own Bentley engine's in a Fokker, they shot down." " I need to see it." " Of course." "I need to see it at once." "Get me the damn report, now!" "Just three more weeks, Manfred." "I already had my marching orders." "I'm going to join your combat wing." "What's become of him?" "Fallen in combat." "And him, his name is Voss, right?" "They are all dead." "I will fight with you and Lothar!" "Our big offensive is in full preparation." "They called it "Operation Michael."" "We will win this war, won't we?" "Wolfram, please..." "It's alright, father." "Of course we'll win." "The Allies don't have a clue about what's coming at them." "For weeks we've been flying out, and decepting their reconnaissances." "Keeping them from finding out where we'll breakthrough." "And we did a bloody good job." "This offensive is going to push them back into the channel." "Sir!" "Morning, sir!" "Please... follow us, sir." "Take cover!" "What an unexpected surprise!" "You came to visit another British defeat, captain." "Lieutenant, go and see if you could find somebody with a camera." "It's excellent propaganda and makes a very good picture." "We have our flying ace down here with us, on this victorious day." "Your excellency, we need to talk." "You don't want me down here." "If you give me the power to make strategic decisions, you won't have like them." "Why wouldn't we?" "We very much trust your abilities, Baron." "I suggest we surrender!" "Huh... what arrogances..." "What a pompous child you are!" "I was victor... in 63 aerial battles." "You know how I did it?" "When I faced a battle I couldn't win," "I flew away." "What makes you think we cannot win this war?" "What about our boys?" "Our holy cause..." "Our soldiers out in the field..." "You want to give all our efforts to the enemy von Richthofen!" "French... great cigarettes." "What makes us think our causes is better than the French, or the British and the Americans?" "It isn't!" "It's not even difference from theirs." "We just need an excuse for what we do because without it we would see who we really are." "Put this fool back into his aeroplane, and give him a parachute." "I can't afford to lose another idealistic hero." "Operation Michael..." "Our ground forces attack on both side of" "Socome town from here and from here." "That's a 70 kilometers battleline." "Right!" "Three armies..." "The 2nd army and 17th army are launching the offensive from here." "The 18th army will attack from here." "Our task is to gain control of the entire airspace and keeps it, my friends." "Shouldn't be a problem should it, Bodenschatz?" "Our planes are outnumber 4 to 1, Udet." "We've lived with that for months and weeks." "It will be worse than ever." "They'll send everything they've got against us." "Fucking cold." "What the hell are you doing?" "Sorry if I have bother you, sir." "What're you doing with my brother's picture?" "He ordered me to take them down." "All of them." "Sir!" "Move out!" "May God be with us." "Gentlemen..." "Let's go!" "Contact!" "Contact!" "Contact!" "He's really back, isn't he?" "His 'Flying Circus' swept the British from the skies!" "I saw him fly past, waving at us." "Sir!" "Gentlemen!" "High Command of the Northern sector thanks us for our accomplishments." "I want to add my thanks." "You've show me some splendid flying." "Thank you." "Bravo!" "Hear!" "Hear!" "Thank you captain!" "This isn't how you imagine your famous cousin to be, is it?" "The glorious captain that you often saw photograph." "Fatherland greatest hero." "The first of all the aces who shot down 80." "Nobody ever down that many." "I am really proud to be his brother." "You can't beat family, Udet." "Peace?" "Peace!" "Is that one of yours?" "I can't tell anymore." "You're flying again, ain't you?" "Why didn't you tell me?" "Why did you lie to me again?" "I didn't want to scare you." "I wanted you to be happy." "Kate, I just cannot do what they asked me." "They offered you safety, your life." "When I was a little boy..." "I could hit all the targets with my father's rifle." "Targets so faraway the others couldn't even see them." "I dreamed of seeing everything." "Trying to think like a bird." "Hawk eyes!" ""Eagle eyes" I was called." "When I became a pilot," "I truly thought I had see everything from up there." "I saw nothing." "I was blind before I met you." "You opened my eyes." "You thought me to see what I didn't want to see." "We all choose to fly." "Voss, Sternberg..." "Lehmann, Wolff..." "Hawker." "On whatever side we fought, we all knew the risks we took." "I wanted to be the best," "I wanted to win and I thought I won." "But I can see now, Kate..." "I have seen." "That we have turn the world into a damn slaughter house." "And I'm already too big a part of it." "They're using my photograph, to give hope where there is none." "They used my name to feign immortality, where else in reality there is annihilation." "You said it yourself," ""The men dying out there, they have no choice"" "I have!" "I cannot order them into battle." "I can perhaps leads them." "Help them!" "Die with them, but I will not betrayed them nor keep the truth from them by remaining the immortal God's Berlin wants me to be." "You are my greatest victory." "Sir?" "Excuse me, sir." "Sir..." "Sir..." "British aeroplanes are approaching the front, sir." "Thank you." "Sir." "Yes, thank you!" "They were last reported at Lagnycourt." "So..." "They are coming in from the Northwest." "Thank you." "Brother." "You don't mind if I lead No:11 and you fly on my right?" "Be my guest." "Wolfram..." "Stayed clear of any involvement." "Keep close to Lothar." "If you are attacked, break off and fly home!" "Fast!" "It's a thin line between cowardice and cleverness." "A great day to fly." "You are a brave man, Baron." "A very brave man..." "Thank you!" "Contact!" "Contact!" "Contact!" "Contact!" "Thank you." "You are welcome." "Miss..." "I could not come sooner." "It's not so easy to cross the line into British territory." "Finally a friend of ours help me." "He asked me why it was important for me to come here?" "I told him I love you." "Did I ever tell you?"

1. Field of the Invention This invention concerns internal combustion engines, and more particularly relates to the starting of such engines without a conventionally employed storage battery or other energy source. 2. Description of the Prior Art Internal combustion engines operate on the principle that a liquid fuel, when ignited and combusted in a cylinder equipped with a reciprocating piston, generates a large volume of gas which pushes the piston toward the opposite extremity of the cylinder. In order to start the engine, fuel must be within the cylinder while the piston is at its outer-most point of travel within the cylinder, often referred to as Top Dead Center of the "power stroke", and means must be provided for igniting or "firing" the fuel. In engines having a multiplicity of cylinders whose pistons cooperatively engage a crankshaft, the sequence of firing of the cylinders is important in the starting and continued operation of the engine. Before the advent of storage batteries, internal combustion engines such as those on automotive vehicles were started by hand-cranking. The crank was geared so as to rotate the crankshaft. When manually rotated, the crankshaft performs the several sequential steps involved in the normal running of the engine, namely: feeding fuel to the cylinders, producing properly staged movement of the pistons, and supplying a magneto-generated spark to appropriate cylinders by way of a "distributor" switching device. However, the manual cranking of an engine is difficult even with relatively small engines, and almost impossible with high horsepower engines employed in modern vehicles. Internal combustion engines, as on automotive vehicles, can be extremely difficult to start in cold weather or after long standing, even when the engine is equipped with a heavy duty storage battery and starter motor adapted to rotate the crankshaft. Various expedients have been proposed for starting internal combustion devices. For example, explosive devices have been disclosed in U.S. Pat. No. 1,877,936 and elsewhere. Modifications involving the delivery to the cylinders of a highly volatile starting fuel such as dimethyl ether is disclosed in U.S. Pat. Nos. 2,053,321; 3,494,340; 3,661,133; 5,119,775 and 5,195,477. U.S. Pat. No. 2,348,621 concerns an engine starting system equipped with means driven independently of the normal engine timing for effecting intake and exhaust in the engine cylinders and for timing the ignition means. The equipment required is of complex construction, and cannot be feasibly retrofitted onto engines of ordinary design. Also, a storage battery and accompanying starter motor are still necessary components of this system. It is accordingly an object of the present invention to provide a method for starting an internal combustion engine. It is a further object of this invention to provide a method as in the foregoing object which does not require use of a storage battery, starter motor or other energy source such as a flywheel or external means of cranking the engine. It is another object of the present invention to provide manually operable apparatus for accomplishing the aforesaid method for starting an internal combustion engine. It is a still further object of this invention to provide apparatus of the aforesaid nature which is easily installable upon and compatible with internal combustion engines of conventional design. These objects and other objects and advantages of the invention will be apparent from the following description.

A glutathione-based hydrogel and its site-selective interactions with water. Glutathione (gamma-glutamyl-cysteinyl-glycine; GSH) is ubiquitous biological tripeptide with multiple functions and possible therapeutic uses. The oxidized disulfide form (GSSG) self-assembles into fibrillar aggregates and gels in organic solvents, but not in solvent mixtures with high water content. Here, the disulfide bond has been replaced with a pyrenyl moiety in order to test the ability of GSH to direct noncovalent self-assembly in H2O, when combined with a hydrophobic driving force for aggregation. The resulting GSH-pyrene forms gels in 95% H2O:5% DMSO. The gamma-glutamyl group is critical for gelation, as it is with GSSG organo-gels, inasmuch as neither S-(pyrenyl)-cysteinyl-glycine nor the iodo-acetamido-pyrene precursor gels under any conditions studied. Circular dichroism and fluorescence spectroscopy indicate that the pyrene moieties cluster within the gels. Scanning and transmission electron microscopy reveal fibrous networks with individual strands of approximately 50-100 nm diameter. Saturation transfer difference (STD) NMR studies demonstrate that water interacts strongly with GSH-borne protons in both solution and gel states, but only the gels include water-pyrenyl interactions with significant residence times.

Interaction between monocytes and vascular smooth muscle cells induces expression of hepatocyte growth factor. To investigate the expression of hepatocyte growth factor (HGF)--a multifunctional factor implicated in tissue regeneration, wound healing and angiogenesis--that is induced by cell-to-cell interactions between monocytes and vascular smooth muscle cells (VSMCs), using coculture of human VSMCs and cells of the human monocytoid cell line, THP-1. We collected supernatant from the coculture medium and measured HGF concentrations with an enzyme-linked immunosorbent assay. Northern blot analysis of HGF mRNA was performed using a specific cDNA. To explore which types of cells produce HGF, we performed immunohistochemistry. Coculture of VSMCs with THP-1 cells for 24 h caused a fivefold increase in HGF concentrations over that in control VSMC culture. Northern blot analysis showed an induction of HGF mRNA in the coculture with a peak at 3 h. Separated cocultures demonstrated that both direct contact and soluble factors contribute to the production of HGF. Immunohistochemistry demonstrated that both types of cells in the coculture produce HGF. Neutralizing antibodies against tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 inhibited the HGF production in THP-1 cells and VSMCs that was induced by the coculture conditioned medium. The protein kinase C inhibitors H-7, calphostin C and K252b, and the tyrosine kinase inhibitor, genistein, significantly inhibited the production of HGF in the coculture. Cell-to-cell interactions between monocytes and VSMCs induced HGF synthesis in both types of cells, suggesting that local HGF production induced by this cell-to-cell interaction has an important role in the pathogenesis of hypertension, atherosclerosis or vascular remodelling.

Our laboratory studies the molecular pathogenesis of human lymphoid malignancies and has three primary goals: to establish a new molecular diagnosis of human lymphoid malignancies using gene expression profiling, to elucidate the oncogenic pathways that result in malignant transformation of normal B lymphocytes, and to identify molecular targets for development of novel therapeutics for these cancers. To provide a molecular basis for the diagnosis of human lymphoid malignancies, we are exploiting DNA microarray technology to profile gene expression in these cancers on a genomic scale. The laboratory created a novel DNA microarray, the "Lymphochip", which is enriched in genes that are expressed in and/or function in lymphocytes (1). We have used Lymphochip and Affymetrix microarrays to profile gene expression in diffuse large B cell lymphoma (DLBCL) (2-4), chronic lymphocytic leukemia (CLL) (5, 6), mantle cell lymphoma (7), follicular lymphoma (8), multiple myeloma (9), and in a wide variety of normal lymphoid subsets (2, 10-13). One central goal of these studies is to relate gene expression to clinical outcome, thereby establishing a quantitative, reproducible and informative molecular diagnosis of the lymphoid malignancies (14). Our studies have revealed previously unknown types of diffuse large B cell lymphoma that are indistinguishable by current diagnostic methods, but which have strikingly distinct gene expression profiles, originate from different stages of B cell differentiation, utilize distinct oncogenic mechanisms, and differ in their ability to be cured by current chemotherapy (2-4). For several lymphoid malignancies, we have identified molecular profiles that predict the length of survival or the ability to be cured by chemotherapy, thereby providing clinically useful prognostic indicators. Our laboratory has mounted a major effort to create a diagnostic microarray that could provide these molecular diagnoses and prognoses to patients with lymphoid malignancies. Importantly, the genes that are associated with clinical prognosis have provided new targets for therapy of the lymphoid malignancies. Our laboratory uses functional genomics, chemical genetics and molecular biological techniques to validate these and other molecular targets, towards the ultimate goal of targeted therapies for patients aimed directly at the disordered regulatory biology of their individual tumors. MOLECULAR DIAGNOSIS OF LYMPHOID MALIGNANCIES Molecularly and clinically distinct diseases within diffuse large B cell lymphoma (DLBCL) DLBCL has long been enigmatic in that 40 percent of patients can be cured by combination chemotherapy whereas the remainder succumb to this disease. By gene expression profiling, the laboratory discovered that DLBCL is actually comprised of at least three different diseases that are indistinguishable by current diagnostic methods (2-4, 15). As detailed below, these DLBCL subgroups can be considered distinct diseases in that they originate from B cells at different stages of differentiation, utilize distinct oncogenic mechanisms, and differ significantly in their survival rates following chemotherapy. DLBCL subgroups originate from distinct stages of B cell development One subgroup of DLBCL, termed germinal center B cell-like (GCB) DLBCL, expresses genes that are hallmarks of normal germinal center B cells. By contrast, another DLBCL subgroup, termed activated B cell-like (ABC) DLBCL, lacks expression of germinal center B cell-restricted genes and instead expresses genes that are induced during mitogenic stimulation of blood B cells (2). These two subgroups of DLBCL differ in the expression of thousands of genes, and in this respect they are as different as acute myelogenous leukemia is from acute lymphoblastic leukemia. Clues to the normal cellular counterparts of these DLBCL subgroups have been provided by our laboratory's analysis of regulatory factors that control the differentiation of germinal center B cells to plasma cells. We and others showed that BCL-6 is a transcriptional repressor that is required for mature B cells to differentiate into germinal center B cells during an immune response (16, 17). Normal germinal center B cells express BCL-6 at high levels but BCL-6 expression is silenced during plasmacytic differentiation. DLBCLs belonging to the GCB subgroup express BCL-6 at high levels but those belonging to the ABC subgroup do not. BCL-6 is deregulated by chromosomal translocations in roughly 20% of DLBCLs, but the high expression of BCL-6 in GCB DLBCLs is not accounted for by these translocations. Rather, BCL-6 is expressed in GCB DLBCLs along with a host of other germinal center B cell restricted-genes because these DLBCLs are derived from normal germinal center B cells and retain much of their biology. In keeping with this notion, GCB DLBCLs have ongoing somatic hypermutation of their immunoglobulin genes, a characteristic feature of normal germinal center B cells (18). The cell of origin of ABC DLBCL has not been fully elucidated, but may be a plasmablastic B cell that is poised to exit the germinal center. Support for this notion comes from our laboratory's analysis of two regulatory factors that are required for plasmacytic differentiation, Blimp-1 (19) and XBP1 (20). By gene expression profiling, our laboratory demonstrated that BCL-6 blocks the expression of Blimp-1, and when BCL-6 activity was inhibited in a lymphoma cell line, Blimp-1 was induced and plasmacytic differentiation was initiated (21). We went on to show that Blimp-1 is a transcriptional repressor that extinguishes the expression of virtually all germinal center B cell genes, including BCL-6 (22). Blimp-1 and BCL-6 thus form a double negative autoregulatory loop that controls plasmacytic differentiation. Blimp-1 enables the expression of XBP1, which our laboratory showed is a master regulator of the secretory phenotype of plasma cells (23). XBP1 induces the expression of a large set of genes encoding components of the endoplasmic reticulum and golgi, leading to a dramatic expansion of the secretory apparatus (23). In addition, XBP1 increases the overall rate of protein synthesis by 50%, which contributes to the high rate of immunoglobulin secretion by plasma cells (23). In comparison to GCB DLBCLs, ABC DLBCLs are characterized by high expression of XBP1 and its target genes, as well as Blimp-1 (4). This phenotype is similar to that of a rare subpopulation of plasmablasts in the germinal center, which are thought to be in the process of migrating to the bone marrow where they will differentiate fully into plasma cells (24, 25). ABC DLBCLs do not express a variety of other genes that characterize normal plasma cells and multiple myeloma, suggesting that they are derived from a cell that is intermediate between a germinal center B cell and a plasma cell. In support of this notion, ABC DLBCLs have somatically mutated immunoglobulin genes, and therefore are derived from a B cell that has likely traversed the germinal center (18). However, in contrast to GCB DLBCLs, ABC DLBCLs have a fixed complement of immunoglobulin gene mutations, suggesting that the somatic hypermutation machinery has been inactivated as occurs normally during plasmacytic differentiation. Primary mediastinal B cell lymphoma: A distinct subgroup of DLBCL related to Hodgkin lymphoma Recently, we and others developed a molecular diagnosis of a third subgroup of DLBCL, termed primary mediastinal B cell lymphoma (PMBL) (15, 26). PMBL cannot be reliably distinguished from other types of DLBCL by current clinical criteria. PMBL was readily distinguished from GCB and ABC DLBCL by the expression of hundreds of genes, and we were able to develop a molecular diagnosis of PMBL.

Relation of virus particle counts to the hemagglutinating activity of influenza virus suspensions measured by the HA pattern test and by use of the photometric HCU method. The ratios of the number of virus (n.v.p.) to the hemagglutinating activity were determined for a series of influenza A and B strains using both the photometric HCU method and the HA pattern test. The logarithms of the ratios of n.v.p./hcu ranged from 7.06 to 7.54 and the logarithms of the ratios of n.v.p./HA from 6.87 to 7.56. While the n.v.p./HA ratios of different strains showed significant differences in a number of cases, such differences were not found for the n.v.p./HCU ratios with the only exception of the strain B/Hong Kong/8/73 differing uniformly from the other strains tested. Since the standard deviation of HCU values ranged from 0.006 to 0.039 log units and that of HA titers from 0.076 to 0.272 log units, it was concluded that the differences of n.v.p./HA ratios found were due to the range of variance of HA tests and did not reflect strain specific differences. The degree of purity of virus suspensions was found not to influence measurably the log n.v.p./HCU values.

The most commonly used club in a typical golf bag is the putter. Approximately one-third to one half of a golfer's strokes on the golf course are taken using a putter. The design of golf putters varies widely. Putter heads can be manufactured having different weighting characteristics, sizes, shapes and colors. Putter heads have progressed from a simple blade-shaped design to more sophisticated designs such as mallet-type putter heads which can include particular weight distributions to improve performance. It is well known that weight distribution in a putter head can affect the moment of inertia of the putter head. As used herein, the moment of inertia is defined as the tendency of the putter head to rotate about its center of gravity when impacting a golf ball at locations spaced from the center of gravity. If the putter head is more resistant to twisting upon an off-center impact with the ball, there is a higher likelihood that the ball will move toward the intended target. Thus, a higher moment of inertia translates into greater forgiveness for off-center ball-striking, e.g. increased directional control of the ball. Further, decreasing the tendency of the putter head to twist on impact causes a more direct transfer of energy between the movement of the putter head and movement of the ball, resulting in better distance control while putting. In addition, the weight distribution of a putter head can impact the spin of the ball following contact with the face of the putter. Generally, a putter head that provides the ball with a certain amount of topspin while reducing the likelihood of sidespin or skidding along the surface of the green is desired. Traditionally, putter heads have been formed entirely of metal, such as stainless steel or other alloys. Current putter heads can include face inserts formed from materials that are different than the remainder of the putter head. However, achieving the precise weight and balance, along with a high moment of inertia to provide a more optimal loft and a truer roll of the ball following impact has historically been difficult, if not elusive. Accordingly, the need exists to provide a putter head having improved weighting and balance characteristics for a more consistent putting stroke and improved loft and roll of the ball after impact. A further need exists to provide a putter head having a high moment of inertia for to maintain a truer roll and decreased twisting of the putter head upon impact with the ball. Another need exists to provide a putter that is easy to use and cost-efficient to manufacture.

Studies on immune competence in the rat: changes with age, sex, and strain. Reticuloendothelial capacity (determined by colloidal carbon clearance) and cell-mediated immunity (determined by xenograft skin grafts and macrophage migration inhibition in vitro) were studied as a function of age for the first time in male and female Sprague-Dawley rats. The results of all three tests in the female rat indicated that maximal immune competence was reached at the onset of puberty (4 weeks) and, depending on the immune response, immune competence declined significantly with age (4 to 96 weeks). In the male Sprague-Dawley, a similar pattern was found in two out of the three tests (colloidal carbon clearance, xenograft skin grafts). Macrophage migration inhibition in the male was unaffected by age (4 to 40 weeks). Cell-mediated immunity (xenograft skin grafts) was also studied in male and female rats of another strain (Long Evans) as a function of age. Maximal competence occurred at the onset of puberty and declined thereafter.

Impact of weight loss between pregnancies on recurrent preterm birth. Low maternal pre-pregnancy body-mass index (BMI) has been associated with preterm birth (PTB). Women delivering preterm are at increased for recurrent PTB. Our goal was to determine whether change in BMI between pregnancies alters the risk of PTB. From our electronic perinatal database, we identified women who delivered consecutive pregnancies at our institution. Women were grouped by prepregnancy BMI category (underweight: <18.5, normal: 18.5-24.9, overweight: 25-29.9, obese: >30 kg/m2). They were then grouped based on change in actual BMI ("increase": >5 kg/m2, "stable": within 5 kg/m2, "decrease": >5 kg/m2) and change in BMI category between pregnancies. The risk of PTB was correlated to change in BMI. P < .05 was considered significant. One thousand two hundred forty-one women met inclusion criteria. Women with a PTB in their first pregnancy had more PTB in their second than those with a term birth in their first pregnancy (33.6% vs 8.0%, P < .001). Women whose BMI decreased more than 5 kg/m2 had more frequent PTB in the second pregnancy than those who did not (21.1% vs 9.3%, P = .01). For those with a term birth in the first pregnancy, PTB in the second did not increase with declining BMI. However, for women with a PTB in the first pregnancy, PTB was more frequent in the second if their BMI decreased a BMI category (53.8% vs 27.6%, P = .05) or if BMI decreased more than 5 kg/m2 (80.0% vs 28.2%, P = .01). Women whose BMI declines between pregnancies are at increased risk for PTB, particularly if they delivered a prior preterm gestation.

A day in the life of women with a serious mental illness: a qualitative investigation. Few studies have taken a holistic perspective to the lives of women with a serious mental illness (SMI). This qualitative study of women with an SMI describes and interprets women's experiences and provides a new understanding about the nature and needs of these women. A convenience sample of 30 poor, urban, predominantly African-American women with a diagnosis of an SMI was recruited from an ongoing National Institutes of Mental Health study. Data collection involved face-to-face, in-depth interviews. The interviews were audio-recorded and transcribed verbatim. Data analysis occurred concurrently with data collection using a modified constant comparative method. The majority of the women self-identified as African American, single, having completed high school, and at the time of the interview were either unemployed or on disability. The most common SMI was major depression. A common topic in the women's reflections on their lives was that of social disadvantage both before being diagnosed as well as after to their diagnosis with an SMI. Salient themes of their stories included social isolation, experiencing loss, and having a lack of control over one's own life decisions. The findings from this study revealed varied experiences among these women as well as the complexity of their situation. The enhanced understanding of women's situation will allow mental health professionals to improve the quality of life for women with an SMI by taking a contextual approach to the treatment of their mental illness.

We have contributed to an intramural NIH collaboration that has cloned the MEN1 gene. We are continuing to explore its clinical and its basic implications. We have proven that it causes nonendocrine tumors (angiofibroma, collagenoma, and leiomyoma). We have identified an MEN1 variant in three large families with infrequent gastrinoma. We find germline mutations in 70-80% of probands with familial MEN1 or at lower prevalence in cases with sporadic MEN1. In contrast, probands with familial isolated hyperparathyroidism have rare (about 5%) MEN1 mutations. Among the MEN1-like families without MEN1 mutation, a rare family shows mutation of the p27 gene. p27 mutation in MEN1 is about 1% the frequency of MEN1 mutation. We have also found rare mutation of p15, p18, or p21 cyclin dependent kinase inhibitor (CDKI) genes. We will continue to explore these and other states for germline MEN1 mutations. We have also found somatic MEN1 mutation in 15 to 35% of sporadic tumors of many endocrine organs. Thus MEN1 is the gene most frequently implicated in common endocrine tumors. We will also determine the spectrum of pathologic states that the MEN1 or the CDKI genes contribute to through mutation and other mechanisms.

EAST HARLEM, Manhattan (WABC) -- Fire marshals have determined that the fire under elevated Metro-North tracks in East Harlem Tuesday night was accidental, caused by fuel spilled on a hot generator during re-fueling.The fire at a garden center halted train service for hours and continued to affect service for the Wednesday commute.Metro-North will operate on an Enhanced Saturday schedule until Friday morning on all three lines.Trains continue to run with delays in and out of Grand Central."We are confident there will be normal service by first thing Friday morning," said MTA CEO Tom Prendergast. "We are working very hard to improve on that time."Train service into and out of Grand Central was suspended on Tuesday night after a large tractor-trailer caught fire under the tracks at East 119 Street and Park Avenue.During the Wednesday morning commute, Metro-North trains traveled through the fire area and took passengers directly to Grand Central Terminal. They ran on the two outside tracks of the viaduct where the fire took place.Train speeds are reduced from 60 mph to a maximum allowable speed of 30 mph. Trains are operating as far as stations in the Bronx, where customers traveling to Manhattan can transfer to the subway to continue their trips.Nearly 100 Metro-North personnel worked through the night to inspect the viaduct to determine the extent of the structural damage and make temporary repairs.Workers brought out heavy machinery to replace damaged beams that support the train overpass, beams compromised by the intense heat of the fire."There are the beams that have been cut to be able to do the temporary repair so that we can take the load off that column, transfer it to another section, open up the two center tracks of the structure and restore normal service," said Prendergast. "It took a while to put out, it was a very intense fire. You can see the damage that was sustained by the structure. The center column is deformed."The heat damaged parts of the original column, which dates back to the viaduct's initial construction in the 19th century.At least 10 cars also caught fire when the two-alarm blaze broke out shortly before 7 p.m. Tuesday. There were some explosions in the fire that were so hot and strong, they blew bolts out of steel.Here's video captured by an Eyewitness News viewer:Though witness reports suggested several propane tanks had ignited, fire officials believe bolts popping out of the elevated track's steel supports sounded like a series of blasts. Firefighters removed 20 propane tanks to prevent explosions.Buildings on both sides of the street were evacuated.

Trends in toothbrushing in 20 countries/regions from 1994 to 2010. For maintaining good oral health, twice-a-day toothbrushing routine is recommended world-wide. As an association between oral diseases and the main non-communicable diseases is confirmed, the importance of brushing is rising. The aim of this article is to describe trends in more-than-once-a-day toothbrushing frequency in 20 countries/regions participating in five consecutive HBSC Surveys between 1994 and 2010. Eleven-, 13-, and 15-year-old children, who replied to the questionnaire in any of the five surveys, were included (N = 474 760). Trends were analysed by logistic regression and multilevel logistic regression modelling. Prevalence of recommended toothbrushing behaviour increased in all countries except in Scandinavia, which had already attained a very high level in 1994. The highest increase (more than + 16%) was observed in Estonia, Russia, Latvia, Finland and in Flemish Belgium. Girls had higher prevalence of toothbrushing than boys (OR = 2.06, 99% CI 2.03-2.10). However, the increasing trend was stronger among boys (OR(2010 vs. 1994) for boys 1.60; for girls 1.48), and among the younger adolescents (OR(2010 vs. 1994) for 11-year-olds 1.64; for 15-year-olds 1.45). Recommended toothbrushing frequency increased in most of the studied countries/regions and differences between the countries diminished during 2004-2010.

[Practical chemistry education provided by team-based learning (TBL) and peer evaluation]. Learning chemistry is cumulative: basic knowledge and chemical calculation skills are required to gain understanding of higher content. However, we often suffer from students' lack of learning skills to acquire these concepts. One of the reasons is the lack of adequate training in the knowledge and skills of chemistry, and one of the reasons for this lack is the lack of adequate evaluation of training procedures and content. Team-based learning (TBL) is a strong method for providing training in the knowledge and skills of chemistry and reaffirms the knowledge and skills of students of various levels. In our faculty, TBL exercises are provided for first-year students concurrently with lectures in physical chemistry and analytical chemistry. In this study, we researched the adoption of a peer evaluation process for this participatory learning model. Questionnaires taken after TBL exercises in the previous year showed a positive response to TBL. Further, a questionnaire taken after TBL exercises in the spring semester of the current year also yielded a positive response not only to TBL but also to peer evaluation. In addition, a significant correlation was observed between the improvement of students' grades in chemistry classes and the feeling the percentage (20%) of peer evaluation in overall evaluation low (logistic regression analysis, p=0.022). On the basis of the findings, we argue that TBL provides a generic, practical learning environment including an effective focus on learning strategy and evaluation of knowledge, skills, and attitudes, and studies on the educational effects of TBL and peer evaluation.

Detection of CRB1 mutations in families with retinal dystrophy through phenotype-oriented mutational screening. Mutations in the crumbs homolog (CRB)1 gene are among the common causes of severe early onset retinal dystrophy. Some characteristic clinical phenotypes are frequently associated with mutations in CRB1. The aim of this study was to examine whether characteristic phenotype-directed mutational screening facilitated the detection of CRB1 mutations. The study included 22 probands with at least one of the potential CRB1-associated phenotypes for retinal dystrophy. Variants were detected using Sanger sequencing. The complete sequences of the coding and adjacent intronic regions of CRB1 were analyzed, revealing homozygous or compound heterozygous mutations in CRB1 in seven of 22 probands, involving six novel (c.136delA, c.1841G>T, c.3017C>A, c.3488G>T, c.3991C>T and c.4089dupTGTTGCTT) and four known (c.2222T>C, c.2671T>G, c.3676G>T and c.4005+2T>G) mutations. The mutations were present in three of four probands with macular nummular pigmentation and in four of seven probands with early onset retinitis pigmentosa with macular involvement. The results suggested that macular nummular pigmentation is a gene-specific indication for CRB1‑associated retinal dystrophy and confirm that CRB1 mutations are also common causes of early onset retinitis pigmentosa. Identification of gene-specific phenotypes is uselful in identifying genetic defects underlying heterogeneous retinal dystrophy.

Journal of Applied Economic Sciences Volume, Issue, 2016 Tangible and intangible rewards in service industries: problems and prospects Tetiana GRYNKO Dnipropetrovsk National University named after Oles Honchar, Ukraine greisy25@gmail.com Oleksandr KRUPSKYI Dnipropetrovsk National University named after Oles Honchar, Ukraine krupskyy71@gmail.com Mykola KOSHEVYI Dnipropetrovsk National University named after Oles Honchar, Ukraine nn.koshevoy@gmail.com Olexandr MAXIMCHUK Dnipropetrovsk National University named after Oles Honchar, Ukraine a.s.kobez2012@mail.ru Abstract Willingness and readiness of people to do their jobs are among the key factors of a successful enterprise. In XXI century intellectual human labour is gaining unprecedented value and is being developed actively. The demand for intellectual labour calls forth an increasing number of jobs and professions that require an extensive preparation, a large number of working places, high level of integration of joint human efforts, growth of social welfare. These trends are becoming ever more pervasive and are spreading widely in service industries, and that explains the rapid development of the latter when compared to the traditional areas of human activity. In its turn, it heightens the need for staff in service companies, supported by significant personnel turnover and a certain shortage of skilled professionals. These circumstances determine the need for developing a new concept of fostering staff motivation at the enterprises in the sphere of services. In order to reach the stated purpose while conducting our research into tourism and hospitality industry, as well as retail chains, we have examined the problems that arise in the process of staff motivation, and studied the foreign practice of motivating staff in hotels. The obtained analysis results enabled us to work out practical recommendations on improvement of the mechanism of tangible and intangible rewards in service companies, which are based on external and internal motivational factors. Additional attention in the article is paid to the statement that financial incentives should be based on key performance indicators (KPI). We give a detailed consideration to the classification of internal motivation incentives of the staff according to the terms of their realization, and give a schematic representation of the performance dynamics of the internal motivation model in service businesses. Keywords: Staff turnover, staff motivation, service industries, internal incentives, management. JEL Classification: J 320, O 150, M 120. 1. Introduction In every country, service industries represents the level of civilization on the nation, so that the higher the level of services is, the more civilized the country is considered. And it is service industries that make the largest part of the national economy in more economically developed countries (over 60%). The rapid development of the service sphere, and its gaining of the status of one of the key sectors of the economy calls forth the need for an increasing number of personnel, which in its turn causes significant staff turnover. This trend is clearly observed in respect of the low-wage employees, and the demand for them is growing exponentially. Staff turnover negatively affects the work of service companies, it is an obstacle to team formation and, consequently, to fostering of the corporate spirit, and this invariably entails a lowering of the overall performance indicators. In addition, the turnover impedes the raising of the staff competence and professionalism level, as well as makes it difficult to get payback of investment in retraining. All this reduces the possibilities of high-quality workforce training: it is provided mainly in the workplace. Although the profession of service sector specialist is gaining popularity among the younger generation, recruiters note the obvious shortage of personnel that complies with the requirements laid down in service companies. Multiple reasons explain for staff turnover – starting from disruptive enterprise management style and Journal of Applied Economic Science no/2006 ending with selection of non-professional applicants to fill in the vacant positions. However, there is no doubt that the path to the effective management of employees lies through understanding of their motivation. Knowing of the factors that stimulate employees and motivate them to their activities should be of the principal consideration while building the effective labour motivation system. All this said, the investigation of the problems and prospects of use of tangible and non-tangible motivation tools in service companies is of particular relevance today and requires additional in-depth research. 2. Theoretical and conceptual aspects The questions of staff motivation are studied by scientists and practitioners from the point of view of theoretical justification of the need for various means of boosting the zeal of employees. An important contribution to the development of the research area was made by such well-known international and Ukrainian scientists as I. Ansoff (1989), J. Cole (2004), M. Meskon, M. Albert and F. Khedouri (2004), L. Balabanova and O. Stelmashenko (2010), M. Shulha (2008) et al. In numerous works, the Ukrainian researchers, for example N. Alekseeva and I. Prykhodko (2012), A. Dolzhanskyi (2010), Z. Zhyvko (2010), N. Izyumtseva and H. Myronchuk (2012), A. Nemchenko, H. Yurchenko and I. Zhyrova (2011) study the mechanisms of establishing interconnections between motivation and work performance through the use of motivational factors and formation of a motivational environment in companies, which stimulates employees to develop their abilities, improve the psychological climate in the team and raise their performance indicators. Such authors as M. Vedernikov (2013), O. Hryvkivska (2010), A. Hubenko (2010), T. Kovalenko (2010), O. Kovalchuk and O. Sytnik (2013), A. Mohsin, J. F. B. Lengler and R. L. Aguzzoli (2015), Branham Leigh (2005) are engaged in research of global experience in the development of motivational systems and their evaluation. However, in spite of a significant number of studies, as well as the currently existing achievements, problems associated with the formation of a practical mechanism of managing staff motivation in services companies have no definite solution. Just the same way, there is no accepted formula for motivation, which would explain the behaviour of an employee, regardless of the circumstances. The methods for managing motivational process call for understanding of the basics of control, with due regard paid to their stochastic ambiguous nature. 3. Purpose of the study Through the analysis of companies that represent tourism and hospitality industry, as well as retail chains, the author strives to explore the problems that came up in the process of motivation, to examine the motivational programmes for the personnel in service industries in the different countries, and then, by using the obtained results, to work out practical recommendations of how to overcome the difficulties and create a new concept of building motivation by personnel in the sphere of services. 4. Results of the study The problems that came up in the process of motivation in service industries First of all, it seems appropriate to mention the problems that exist at the macrolevel and hamper the introduction of any incentive schemes for employees of service industries. These problems seem to be inherent to the countries with national economies under transformation. So, these problems are: 1. Lack of clear standards for requirements to personnel in service companies, as well as lack of qualification standards. 2. Fragmentation and lack of a single standard list of professions related to the service sector. 3. Scarcity of differentiated methods of specialist training for work in the service sector. 4. Lack of standards of educational programmes and a common approach to assessment of service quality and service technologies. 5. Underdevelopment of the labour market. 6. Low level of professional culture of the staff. 7. High staff turnover. Of special note is one of the key problems in the sector of services of any type and orientation. It lies in the fact that the greatest difficulties are related to the motivation of staff employed in soJournal of Applied Economic Sciences Volume, Issue, 2016 called "non-prestigious" service sector jobs (cleaners of the premises, maids, nurses, technicians, repairmen, etc.). The problems are explained by unattractiveness, not prestigious of the professions that form the very basis of the infrastructure of the service-rending process; low wages; poor working conditions, and others. Ever more people in modern society are no longer satisfied with "any" work. People want the work process to give them an opportunity for self-development, self-affirmation and selfrealization, they want to feel the importance and necessity of the performed work (Dwivedula and Bredillet, 2010). More and more often employees try to evaluate the innovation potential of the job, its creative constituent, which plays a significant part in self-identification of a personality (Hrynko, 2010). At the level of a separate enterprise, there are other problems, which hinder the effective implementation of modern concepts of motivation: • lack of a clearly defined policy and specifically worded objectives in work with the staff; • fragmentation in personnel management and planning; • lack of integrated educational framework; • insufficient competence of HR personnel; • low degree of realization of the whole complex of staffing social goals. Of course, there are much more problems at each level; besides, in each individual case they are quite particular and depend on both objective and subjective factors. Low level of motivation, imperfect programmes and systems of stimulation of employees are one of the most crucial factors, which causes a significant personnel turnover in service companies. The annual research conducted by BenchmarkPro that analyses information about 30,000 organizations around the world testifies that the average personnel turnover in the services sector is more than twice as high as that in the industrial sector (see. Fig. 1, 2). Figure 1 Voluntary discharge (CompData Surveys) Figure 2 General personnel turnover (CompData Surveys) As is clearly shown in Fig. 1 and 2, the first place for turnover among service industries holds the industry of tourism and hospitality, and the second one – retail networks. High staff turnover in the tourism and hospitality industry has brought about the crisis of productivity, which costs to the sector $ 272 million per year. According to expert data, 1% increase in labour productivity can provide an additional $ 1.43 billion of revenue in the year. At the same time, labour productivity in the tourism and hospitality industry per employee makes $ 21,600 per year, in retail networks – $ 46,000, and in the industrial sector – $ 52,000 (Brien et al., 2015). Journal of Applied Economic Science no/2006 Antal International company experts in the course of their studies found out that employees of the tourism and hospitality industry leave their positions in search of more interesting work in 67% of cases, and in 65% of cases in search of a better work / life balance (Eisele et al., 2013). In this context, of considerable interest is the gradation of the reasons of dismissals from hotel positions, established by Kelly Services, Inc., the world leader in providing solutions for personnel, as a result of their study of more than 4000 hotels in the USA and Europe (see Fig. 3). So, in the first place lack of career development, on the second the difficulty with management and management of the hotel circuit and the third too many standards and requirements for operation. This material component is only in seventh place. Figure 3 Rating of the reasons of dismissals from hotel positions (% of the sample) (Kelly Services) The generalization of the results of various investigations and surveys has enabled the author to formalize the reasons that account for the hospitality industry employees being not loyal to their work, and that led to their leave (the reasons are enumerated in a free list without regard to priority). Accordingly, these very reasons are the prime guidelines of motivational mechanism, which will allow its adjusting according to the needs, wishes and aspirations of the staff. 1. A significant level of bureaucracy or inadmissible tolerance in the company. There are often quite an excessive number of formulated rules that employees do not understand and do not accept. Once an employee disagrees overtly with these rules and gets disappointed with them, it is the direct reason for his rejection of further cooperation. 2. Lack of transparency. Employees should have the possibility to share their thoughts, concerns and suggestions with the company management. 3. Lack of accountability / responsibility. Good employees want to be responsible for their projects, for the results of their activities and, what is more important, they do not mind being guilty and suffer due punishment, in case of mistakes. Also, they do not object to the control of the management, they are ready to discuss conclusions and comments and listen to advices. 4. The lack of vision and prospects of the enterprise development. Employees need to see and understand where the company is moving, what is their future. 5. Inattention to the talents of employees, lack of appropriate projects that can ignite a passion for work. The head which has a team of talented employees and does not make use of their potential will soon be deprived of this opportunity. It is well known that talented people are driven by not money, but the opportunity to become a part of something huge, and when having such an opportunity, they can increase the cost and competitiveness of the enterprise many times. 6. Lack of discussion on career development. It is very important to conduct a dialogue face to face with an employee about his career path. When management takes part in the debate and demonstrates that there is space for promotion, employees tend to be more loyal to their work. 7. Irregular analysis of performance or its total lack. It entails irregular evaluation of quality and effectiveness of personal efforts, which consequently has a negative impact on remuneration, both material and moral. Journal of Applied Economic Sciences Volume, Issue, 2016 In order to work out specific recommendations for overcoming the difficulties and forming a new concept of building motivation in this area, the next stage seems to be to explore the usual practice of motivating personnel in the tourism and hospitality industry. World experience of personnel motivation in service industries (evidence for hotels) Table 1 Provides an overview of motivational programmes for staff that are used in hotels around the world. Table 1 Motivational programmes for hotel staff Country The content of the motivational programme USA • discount card for hotel services; • payment of newly-employed workers and junior staff is at the level of the minimum wage, but there is an opportunity to earn an increase of 20 to 40 cents per hour due to the additional actions (Association International Hotels and Restaurants Associations); • high productivity entails a salary increase of up to 60% per year, depending on the personnel policy of each hotel; • hourly workers are entitled to receive quarterly bonuses if their performance exceeds the planned expectations; • middle and high managers are offered reduced-price medical care. China • employment contracts are concluded for a period of 3 to 5 years; • there is a possibility of promotion to senior manager in 6 years; • one extra payment of the salary every year; • two free medical examinations a year; • annual guided tour organized by the hotel for the best employees; • rewards such as extra credit programme for the outstanding employees; • regular training programmes aimed at improving skills and creating a sense of community in the team. India • a good salary; • promotion and growth; • an annual bonus; • employee discount cards; • partial payment for medical services; • on the results of the award; • discounts on medical care and life insurance; • competitions and team building exercises to bring together employees and encourage interaction. • at least 22 days of vacation. England • bonuses according to the performance; • discounts on medical care and life insurance; • competitions and team building exercise for bringing employees and encouraging interaction; • at least 22 days of vacation. As is shown in Table 1, about 80% of motivational programmes for hotel staff in all the countries employ financial incentives, which, in fact, are external motivational factors. When comparing the Journal of Applied Economic Science no/2006 information contained in Table 1 and shown in Figure 3, it is easy to see the non-conformity of motivational programmes and expectations of the employees. Practical recommendations for the formation of a new concept of building personnel motivation in service industries In general, one can observe that external stimuli (material component) are used to compensate for repetitive tasks or those tasks that require additional motivation. Various studies have shown that money as an incentive works effectively on the short distance, and when a person reaches a certain level of comfort, the quality of his work deteriorates gradually. People work better when they feel an emotional or personal connection with the work, and when their aspirations and target settings coincide with the aims and objectives of the enterprise. These factors increase their motivation much better than money (Tabassi et al., 2012). Of course, we do not suggest rejecting material incentives, but it seems that its role should be reconsidered, and compilation of monetary compensation programmes should take into account current market trends, aims of the personnel and the latest achievements of scientific thought. Besides, due attention must be paid to gender segregation of labour in service industries. Thus the author holds that the programme of material motivation should be based on proven key performance indicators (KPI) of the enterprise, the choice of which, in turn, should be carried out with compliance with SMART principles. KPI is an efficient tool that helps to coordinate harmonize the values of workers and the enterprise. KPI represent benchmarks for evaluating employees and, on the other hand, enables the employees to monitor the compliance with their own aims and achievement of goals (Mohsin et al., 2015). When developing a system of incentives based on the KPI, first of all it is necessary to identify the key performance indicators of the company and, on that basis, to formulate strategic goals and objectives with their subsequent transfer to the staff level. Though a list and immediate content of the tangible rewards for staff accompanies each goal statement, for certain tasks it is difficult to determine and establish an objective and adequate remuneration for a particular employee. Therefore, there is no doubt that such objectives as "involvement of employees" or "fostering of future leadership qualities" require an additional, internal motivation. On the evidence of retail networks, the correlation of KPI of a company and indicators of material staff stimulation is shown in Fig. 4. Considering the system of non-material incentives in the modern concept of motivation for enterprises of tourism and hospitality industry and retailers, we note that, according to the author, it must be based on self-determination theory, which features three variable predictors – autonomy, competence and cohesion with the company. These variables allow employees to form internal incentives to work, to increase efficiency and to develop a wish to remain in the company for a long time, as well as to participate in its development. According to this theory, instead of being a source of motivation, the manager must help employees to find their own internal motivation. Internal incentives suggest certain relieve of financial burden on the company, when compared with external incentives, which include bonuses, commissions, salary increase, etc. Expenses on these stimuli may exceed their feedback and lead to a yield decrease. Empirical observations and calculations show that job satisfaction in the service sector is but slightly correlated with material rewards. Thus, basing on these results we can offer the quadrant of motivation types for tourism and hospitality companies and retail networks (Fig. 5). If the employee likes what he is doing, then the combination of autonomy, competence (skills), or cohesion with the work and achievements of the company will encourage him to be active, and the efficiency and productivity of his work will be a result of his activity. According to a survey carried out among the employees of Park Inn hotel network in 2014, the first place among the internal motivators shared recognition and growth opportunities (see Fig. 6). The greatest effect is, of course, gives a combination of internal motivators, which excites the feelings that lead to effective customer service and efficient behaviour of employees. Journal of Applied Economic Sciences Volume, Issue, 2016 Figure 4 Correlation of KPI of a company and indicators of material staff stimulation (Retail) Figure 5 Quadrant of incentives and motivations for tourism and hospitality companies and retail networks Journal of Applied Economic Science no/2006 Figure 6 Popularity of internal incentives in Park Inn hotel network (% of the sample) (Sampaio et al., 2014). Basing on the concepts of self-determination theory, we suggest expanding variable predictors to service businesses, by adding self-efficacy, strength, emotions, mood, values, interest, utility, choice, persistence and effort to their number. In this case, the model of internal motivation for service companies, in particular for those who work in the tourism and hospitality industry and trade, will look and work as follows (see Fig. 7). Figure 7 Dynamics of performance of internal motivation model for service companies This model demonstrates that a certain type of behaviour has a very different effect on the efficiency of the enterprise, achieved in various ways, and employers should take these differences into account in order to reduce turnover. In addition, in order to effectively use internal incentives of employees as motivational factors, it would be reasonable for businesses to differentiate them, depending on the timing of implementation (see Table 2). Table 2 Classification of internal incentives as to terms of their implementation Short-term incentives – "quick victories" Long-term incentives – "long victories" Competitions: • competitions between teams of employees/shifts/crews for goal achievement, e. g., the largest number of clients fin a week, the least number of complaints, the quickest service etc.; • rewards, e.g., gift cards, cinema tickets, free lunch etc. Offers for proficiency enhancement and change of profile E. g., training courses. They help employees to feel that their part in the company is not just doing everyday routine work. With the aid of the studies they can build their careers and increase their value for the company. Social recognition: Development of talents Journal of Applied Economic Sciences Volume, Issue, 2016 E. g., most effective worker of the month. The reward can take the form of a poster with a photo on a corporate stand, congratulations of a team gathering – bestowing a certificate, expressing gratitude. • structured education, theoretical and practical training for coping with new tasks; • creation of a reserve for switching employees to other tasks, when needed; in its turn, it makes them feel incorporated into the functioning of the company and performing of new tasks; • the personnel is conscious of the meaning of the performed tasks and commissions; • employees that are qualified for various jobs are aware of their possibilities of career promotion, which inspires them and lets them understand the sense of their work and work of the whole enterprise. Internal notices on vacant positions on the informational stand Such notices gives employees a possibility to consider different roles in the company that they might play, to shape their own sensations and aspirations, which encourages them to work harder and perfect themselves. Flexibility that allows working in a series of company areas a possibility to work in various environments, with various clients and in the various areas; skills improving, which makes the employees quick to adapt to the various groups of clients and their requests; flexible work conditions, including proximity to home, university, school, if they are interested in studying new areas. Team building common monthly lunches; New Year and Christmas parties; monthly teambuilding events, such as picnics, film viewings, visits to clubs; participation in group meetings etc. Conclusions The most complicated situation with personnel and their motivation in service industries is observed in the tourism and hospitality industry, as well as in retail networks. Identification of the problems that arise in the process of motivation in service industries, helped to clarify the basic requirements for the modern concept of tangible and intangible rewards for work in service companies. A detailed analysis is given to the problems and factors causing the highest level of staff turnover, as a result of imperfect motivation programmes in the companies within tourism and hospitality industry, as well as in retail chains. A study of the positive experience of staff motivation in different hotels around the world was performed. Basing on the findings, the article provides practical recommendations that help to overcome the difficulties and create a new concept of building motivation in this area. Special attention is paid to the motivational programmes of material incentives; particular emphasis is placed on internal motivation factors, their classification and model of their implementation are offered. References [1] Ansoff, I. 1989. Strategic management. Ekonomika. Moskow. [2] Alekseeva, N., Prykhodko, I. 2012. Improving work motivation by machine building employees. Management, marketing and personnel administration: Mykhailo Ostrohradsky Kremenchuk National University Gerald, 3:174-178. [3] Association International Hotels and Restaurants Associations (IHRA). URL: http://ih-ra.com/ Journal of Applied Economic Science no/2006 [4] Balabanova, L. V., Stelmashenko, O. V., Tuhan-Baranovsky, M. 2010. Strategic personnel management in market economy. Donetsk National economy and trade university. Donetsk. [5] Brien, A., Thomas, N., Hussein, A. S. 2015. Turnover Intention and Commitment as Part of Organizational Social Capital in the Hotel Industry. Journal of Human Resources in Hospitality & Tourism, 14(4): 357-381. [6] Branham, Leigh. 2005. The 7 hidden reasons employees leave: how to recognize the subtle signs and act before it's too late [online]. American Management Association. New York. http://site.ebrary.com/lib/natl/Doc?id=10075612 [7] Cole, Jerald. 2004. Managing personnel in modern organizations. OOO Vershyna. Moskow. [8] CompData Surveys URL: http://www.compdatasurveys.com/ [9] Dolzhanskyi, A. N. 2010. Organization of workflow on registration of direct expenses in responsibilities centres in printing enterprises. Scientific Gerald of National University of Forest Engineering of Ukraine, 188193. [10] Dwivedula, R., Bredillet, C. N. 2010. Profiling work motivation of project workers. International Journal of Project Management, 28(2):158-165. [11] Eisele, L., Grohnert, T., Beausaert, S., Segers, M. 2013. Employee motivation for personal development plan effectiveness. European Journal of Training and Development, 37(6): 527-543. [12] Hrynko, T. 2010. On innovation potential as a constituent of innovation activities of businesses. The Economist, 2: 56-58. [13] Hryvkivska, O. V. 2010. Staff motivation in foreign companies. Topical problems of economy, 9: 86-91. [14] Hubenko, A. V. 2010. Importance of labour potential for economic development of a company. Economy and marketing in XXI century, 1:78 -80. [15] Izyumtseva, N. V., Myronchuk, H. V. 2012. Organization of system of motivation of bank personnel under conditions of post-crisis development of economy. Personnel management: Herald of University of Banking of National Bank of Ukraine, 1: 279-283. [16] Kelly Services. Inc. Business Services & Solutions. URL: http://www.kellyservices.us/US/Business-Services/ [17] Kovalchuk, O. A. 2013. Economical and mathematical modeling of managing the process of personnel motivation. Dnipropetrovsk university Gerald. Series Economy 21. 7(4): 268-273. [18] Kovalenko, T. L. 2010. Factors of social and economical motivation of personnel of communications service provider. Author's abstract of a thesis of PhD in economy: 08.00.04. O. S. Popov Odesa national academy of communications. [19] Meskon, M. Kh., Albert, M., Khedouri, F. 2004. Basic management. Delo. Moskow. [20] Mohsin, A.; Lengler, J. F. B.; Aguzzoli, R.L. 2015. Staff Turnover in Hotels: exploring the quadratic and linear relationships. Tourism Management, Forthcoming. Tourism Management, 51: 35-48. [21] Nemchenko, A. S., Yurchenko, H. M., Zhyrova, I. V. 2011. Analysis of motivational principles of personnel management. Mangement, economy and quality assurance in Pharmacy, 1:18-23. [22] Sampaio, S., Simoni, V., Isnart, C. 2014. Tourism and Transformation: Negotiating Metaphors, Experiencing Change. Journal of Tourism and Cultural Change, 12(2):93-101. [23] Shulha, M. A. 2008. Social and political management. Tsentr uchbovoi literatury. Kyiv. [24] Tabassi, A.A., Ramli, M., Bakar, H.A. 2010. Effects of training and motivation practices on teamwork improvement and task efficiency: the case of construction firms. International Journal of Project Management, 30(2): 213-224. [25] Vedernikov, M. D., Zelena, M. I. 2013. Is it reasonable to use foreign experience in Ukrainian companies. Khmelnytskyi national university Gerald, 5(1):18-21. [26] Zhyvko, Z. B. 2010. Mechanism and models of personnel motivation in call producing companies. Management and marketing. Science and economy, 1: 86-91.

NEW DELHI: Prime Minister Narendra Modi on Sunday said his four-nation tour of Germany, Spain, Russia and France beginning tomorrow is aimed at boosting India's economic engagement with these nations and inviting more investment.In the first leg of his six-day trip, he will visit Germany, where he will hold talks with Chancellor Angela Merkel under the framework of India-Germany Intergovernmental Consultations (IGC).He will also call on German President Frank-Walter Steinmeier.Modi said he and Merkel will "chart out a future roadmap of cooperation with focus on trade and investment, security and counter-terrorism, innovation and science and technology, skill development, urban infrastructure, railways and civil aviation, clean energy, development cooperation, health and alternative medicine."Describing Germany as a valuable partner, the prime minister said, "German competencies fit well with my vision for India's transformation."In Berlin, Modi and Merkel will also interact with top business leaders of both the countries to further strengthen the trade and investment ties."I am confident that this visit will open a new chapter in our bilateral cooperation with Germany and further deepen our Strategic Partnership," he said in a Facebook post.On Tuesday, Modi will travel to Spain for an official visit, the first by an Indian prime minister in almost three decades.He will call on King Felipe VI and hold talks with President Mariano Rajoy."We will discuss ways to enhance bilateral engagement, especially in the economic sphere, and cooperation on international issues of common concern, particularly in combating terrorism," he said.The prime minister said there is significant potential for deepening bilateral trade and investment ties."We seek active participation of Spanish industry in various Indian projects including infrastructure, smart cities, digital economy, renewable energy, defence and tourism," he added.He will also meet top CEOs of the Spanish industry and encourage them to partner in the 'Make in India' initiative."I look forward to their valuable recommendations for strengthening India-Spain economic partnership," he wrote.From Spain, the prime minister will travel to St. Petersburg in Russia from May 31 to June 2 for the 18th India-Russia Annual Summit."...I will be conducting detailed discussions with President Putin to take forward our dialogue from the last Summit in Goa in October 2016," he said.The two leaders will also be interacting with CEOs from the two countries.On June 2, Modi and Putin will address the St. Petersburg International Economic Forum (SPIEF) where India is the 'guest country'."In a first meeting of its kind, I will also have the opportunity to engage with Governors from various Russian regions to further broad base bilateral cooperation and more actively involve States/Regions and other diversified stakeholders," he said.At the beginning of his visit, he will go to Piskarovskoye Cemetery to pay homage to those who perished during the siege of Leningrad.He will also visit the world famous State Hermitage Museum and the Institute of Oriental manuscripts."I greatly look forward to my visit to St. Petersburg in this special year for the bilateral relationship as both countries celebrate the 70th Anniversary of our diplomatic relations," Modi said.In the last leg of the tour, he will visit France from June 2 to 3 for an official meeting with the newly-elected French President Emmanuel Macron."France is one of our most important Strategic Partners. I look forward to meeting President Macron and have discussions on issues of mutual interest," Modi said."I would be exchanging views with the French President on important global issues including UN Security Council reforms and India's permanent membership of the UN Security Council, India's membership of the various multilateral export control regimes, counter-terrorism cooperation, collaboration on climate change and International Solar Alliance," he added.France is India's 9th largest investment partner and a key partner in its development initiatives in the area of defence, space, nuclear and renewable energy, urban development and railways."I am committed to substantially strengthening and advancing our multi-faceted partnership with France," the prime minister said.

The goal of the Animal Resources core will be to generate and maintain transgenic mouse lines derived from genetically manipulated embryonic stem (ES) cells lines that will be developed in Projects II and III. The core will also provide animals for analysis, testing, and mating as needed by Program II, III, IV and Core B. Primarily, mouse lines will be generated through blastocyst injection of ES cells, however, this core will also be able to generate standard transgenic mouse lines through pronuclear microinjection of DNA constructs, as necessary. It is estimated that two to three ES cell lines will be injected for each construct and that one to two lines of mice will be maintained for each construct, depending on the phenotype and expression levels in each line. The Core will maintain breeding stocks and study animals for six transgenic mouse lines and appropriate control strains that are currently under study in Program II and III and Core B. The Core will also provide animals for mating by Project IV. The Core will oversee DNA typing, breeding record, and pedigrees for these lies and all subsequent lines that are developed by the project. The Animals Core will also maintain breeding stocks of C57BL/6J mice for production of blastocysts and CD-1 females and vasectomized males for production of pseudopregnant host females. Breeding stocks of FVB/NJ mice and a transgenic line of FVB/NJ mice carrying a pSV40tkneo construct will be maintained to provide embryonic fibroblast feeder cells for maintenance and selection of ES cells. The average daily census for the Animal Core is expected to be 500. All animals will be maintained in micro-isolator cages in a pathogen-free facility at the Johns Hopkins Medical School. The Animal Core w ill also be able to maintain frozen stocks of embryos from transgenic lines that are no longer needed for immediate production of study animals.

This invention relates generally to electric submersible pumps and more particularly concerns systems for supplying oil to such pumps during downhole operation. The upper operating temperature for an electric submersible pumping system is limited by the degradation of the motor oil and the motor insulation due to temperature and by the ability of the thrust bearing to function at elevated temperatures. It has long been recognized that a continuous fresh oil supply increases the life expectancy of the unit. Present oil feed systems depend on the use of complex, surface controlled, pressure balancing and metering systems and require specially developed sub-surface pressure regulating valves that operate at elevated temperatures in the well fluid. These complex regulating systems are used because of the difference in the height of the column of fluid in the well bore and the height of the column in the oil supply tubing, which could amount to several thousand feet. The motor and the seal system could not handle the pressure that this fluid level differential represents. Even if they could, the volume of oil required if oil was allowed to flow freely would be cost prohibitive. In normal operation, the electric submersible pump motor oil is contained in a closed system. The expansion of the motor oil when the motor comes up to operating temperature is offset by storage in a reservoir and is returned to the system when the motor is shut down. On the initial start, the excess oil is vented to the well bore. Such a system typically requires a quarter inch inner diameter tube extending some three to six thousand feet downhole to the motor. In a free flow condition, several barrels of oil per day flow to the motor. This translates into thousands of dollars a day just for the oil necessary to keep the system running. A further problem with the present fresh oil supply systems is that the oil is introduced at a bellows below the motor with the oil then passing upwardly through the motor and being released at a relief port at the top of the motor. This reduces the effectiveness of the oil by the time it reaches the pothead cavity which is the most likely breakdown point in the system. It is, therefore, an object of this invention to provide an oil supply system for an electric submersible pump which eliminates the need for a downhole pressure regulator. It is a further object of this invention to provide an oil supply system for an electric submersible pump in which the continuous flow of oil is limited to less than ten and preferably to approximately one to five gallons of oil per day. Another object of this invention is to provide an oil supply system for an electric submersible pump which does not require a downhole oil reservoir. It is also an object of this invention to provide an oil supply system for an electric submersible pump in which the oil is introduced to the pump motor at the pothead cavity.

The aims of this application by the Forsyth County Field Center are to recruit and examine 666 white and African American individuals selected according to the study design described in this application. The Forsyth County Field Center will contribute 500 white, and 166 African-American study participants, stratified into families with 2 or more hypertensive siblings, untreated relatives, and controls. The source population will be individuals previously examined by the Family Heart Study and the Atherosclerosis Risk in Communities Study, and their siblings. Previously collected data by these parent studies will make it convenient and efficient to identify individuals in the required categories according to hypertension status, treatment status, and availability of siblings defined according to previously reported history of hypertension. The examinations will take place at the Forsyth County Field Center, one of six field centers participating in the Network on Genetic and Interacting Determinants of Hypertension. This field center currently serves as the recruitment and examination facility for the Family Heart Study and the ARIC Study. Recruitment and examination of study participants will be carried out according to a standardized protocol, common to all Network field centers, and subject to the quality control procedures in place for the Network as a whole to ensure that data can be appropriately pooled. Analytic methods will cover genetic association and model-free sibship linkage with adequate statistical power to detect specific genetic loci which promote hypertension, for the African American and non-black populations inducted in this Network. Epidemiologic analyses will follow, to identify gene-environment interaction in sub- populations with, and without confirmed genes for hypertension in relation to specific lifestyle factors putatively associated with the likelihood of expression of genetic predispositions to hypertension.

"What gives you that idea?" "You want to know the secret to surviving air travel?" "After you get where you're going, take off your shoes and socks." "Then you walk around on the rug barefoot and make fists with your toes." "Fists with your toes?" "I know." "It sounds crazy." "Trust me." "I've been doing it for nine years." "Yes, sir!" "Better than a shower and a hot cup of coffee." "OK." "It's OK." "I'm a cop." "Trust me." "I've been doing this for 11 years." "On behalf of the captain and the crew,... ..l'd like to welcome you to Los Angeles." "Have a very merry Christmas." "Flight247 to Tucson now boarding at gate 14." "Flight 247 to Tucson now boarding at gate 14." "How do you do?" "Ladies and gentlemen,..." "Ladies and gentlemen!" "I want to congratulate each and every one of you... ..for making this one of the greatest years... ..in the history of the Nakatomi Corporation." "On behalf of the Chief Executive Officer, Mr Ozu,... ..and the Board of Directors,... ..we thank you one and all... ..and wish you a merry Christmas and a happy New Year!" "Happy New Year!" "Hey, Holly." "What about dinner tonight?" "Harry, it's Christmas Eve." "Families, stockings,..." "Chestnuts?" "Rudolph and Frosty?" "Any of these things ring a bell?" "Actually, I was thinking more of... ..mulled wine, a nice aged Brie... ..and a roaring fireplace." "You know what I'm saying?" "Ginny, it's 5.40." "Go join the party." "Have some champagne." "You're making me feel like Ebenezer Scrooge." "Thanks." "Do you think the baby can handle a little sip?" "That baby's ready to tend bar." "Last chance." "Bye." "McClane residence." "Lucy McClane speaking." "Hello, Lucy McClane." "This is your mother speaking." "Mommy!" "When are you coming home?" "Pretty soon." "You'll be in bed when I get there, though." "Let me talk to Paulina, OK, hon?" "And no snooping around the house looking for presents." "Is Daddy coming home with you?" "Well, we'll see what... ..Santa and Mommy can do, OK?" "Put Paulina on." "Bye, honey." "Paulina!" "Hola, Mrs Holly." "Um, did Mr McClane call?" "No, Mrs Holly." "No telefono." "He probably didn't have time before his flight." "It might be a good idea to make up the spare bedroom... ..just in case." "Si, Mrs Holly." "I do that already." "What would I do without you, Paulina?" "California!" "Hey, I'm John McClane." "Argyle." "I'm your limo driver." "Nice bear." "OK..." "Argyle." "What do we do now?" "I was, uh, hoping you could tell me." "It's my first time driving a limo." "That's OK." "It's my first time riding in one." "We got everything in this mug, man." "Look at this..." "CD, CB, TV,... ..telephone, full bar, VHS." "If your friend's hot to trot,... ..l know a few mama bears we can hook up with." "Or is he married?" "He's married." "OK." "Sorry about that." "It's the girl's day off." "I didn't know you were gonna sit up front." "Your lady live out here?" "About the past six months." "Meaning you still live in New York?" "You always ask this many questions, Argyle?" "Sorry." "I used to drive a cab and people would expect a little chitchat." " So, you divorced?" " Just drive the car, man." "Hey, come on." "You divorced?" "You separated?" "She beat you up!" "?" "She had a good job." "It turned into a great career." " That meant she had to move here." " You're very fast, Argyle." "So, why didn't you come?" "Why didn't you come with her?" "Because I'm a New York cop." "I got a backlog of New York scumbags I'm still trying to put behind bars." "I can'tjust go that easy." "You thought she wasn't gonna make it out here... ..and she'd come crawling back to you so why bother to pack, right?" "Like I said, you're very fast, Argyle." "Mind ifwe hear some tunes?" "Hey, that'll work." "Don't you got any Christmas music?" "This is Christmas music." "So your lady sees you, you run into each other's arms,... ..the music comes up and you live happily ever after, right?" "I can live with that." "So, if it doesn't work out, you got a place to stay?" "I'll find a place." "I tell you what..." "I'll wait in the parking garage." "You score, give me a call on the car phone." "I'll take your bags to the desk." "You strike out, I'll get you a hotel." " You're all right, Argyle." " Remember that when you sign for the tip." " Hi." " Good evening." "I'm here to see Holly McClane." "Just type it in there." "Cute toy." "Yeah, if you have to take a leak, it'll even help you find your zipper." "Christ." " Thirtieth floor?" " The party." "They're the only ones left in the building." "Take the express elevator." "Get off where you hear the noise." "Thanks." " Champagne, sir?" " Yeah, thanks." "Oh, I'm sorry." "Hey!" "Merry Christmas!" "Jesus." "Fuckin' California!" "I couldn't agree with you more." "Why don't I talk to him right now?" "Hi." "I'm looking for..." " Holly Gennero." " Yeah." "Then you must be John McClane." "Joe Takagi." "How was your ride in?" "Nice." "I have you to thank for that?" "Seemed the least we could do." " Quite a place you have here." " It will be ifwe ever get it finished." "Still several floors under construction." "Holly went to fax some documents." "She should be back any minute." "In the meanwhile, her office is back here." "Ellis?" "I was just making a call." "This was the nearest phone." "I want you to meet John McClane,... ..Holly's husband." "Holly's policeman." "Ellis is in charge of international development." "Heard a lot about you." "You missed some." "Can I get you anything?" "Food?" "Cake?" "Some watered-down champagne?" "No, thank you." "I'm fine." "You throw quite a party." "I didn't realise they celebrated Christmas in Japan." "We're flexible." "Pearl Harbor didn't work out, so we got you with tape decks." "It's sort of a double celebration." "We closed a pretty big deal today... ..and a lot of it was due to Holly." "Right, Joe?" "I'll be out in a couple of minutes." "John." "Have you met everyone?" "We've been sticking him with spears." "Of course he has." "She was made for the business." "Tough as nails." "I was hoping you made that flight." "Show him the watch." "Later." "Show him." "Are you embarrassed?" "It's just a small token of appreciation... ..for all her hard work." "It's a Rolex." "I'm sure I'll see it later." "Is there a place where I could wash up?" "Sure." "You have to forgive Ellis." "He gets very depressed this time ofyear." "He thought he was God's greatest gift, you know?" "I know the type." "I think he's got his eye on you." "That's OK." "I have my eye on his private bathroom." "Where are you staying?" "Things happened so fast... ..l didn't get a chance to ask you on the phone." "Cappy Roberts retired out here." "Oh, yeah?" "He said I could bunk with him." "Cappy retired, huh?" "Where's he live?" " Romona." " Ha!" "Pomona." " Huh?" " Pomona." " Pomona." " Yeah." "You'll be in the car halfthe time." "Why don't we make it easy?" "I have a spare bedroom." "It's not huge or anything, but... ..the kids would love to have you at the house." "They would, huh?" "I would, too." "Ha ha!" "Ooh!" "Sorry." "I missed you." "Didn't miss my name, though, huh?" "Except maybe when you're signing cheques?" "Since when did you start using Ms Gennero?" "This is a Japanese company." "They figure a married woman's..." "You are a married woman." "This conversation again?" "We did this in July." "We never finished this conversation." "I had an opportunity." "I had to take it." "No matter what it did to our marriage." "It only changed your idea of our marriage." "You have no clue what my idea..." "I know exactly what your idea of our marriage should be." "Ms Gennero, I..." "Excuse me." "Hi." "Um, Mr Takagi is looking for you." "He wants you to say something to the troops." "Thank you." "Speech time." "Be back in a few minutes." "That was great, John." "Good job." "Very mature." "So Kareem rebounds." "Feeds Worthy on the break, over to AC, to Magic,... ..then back to Worthy." "Boom!" "Two points." "We're in." "Links... ..rechts... ..und wieder links." "Son of a bitch." "Ha ha!" "Fists with your toes." "Yeah, Argyle?" "How's it going?" "All right." "Where are you?" "Down at the garage." "What's with you and your lady?" "The vote's not in yet." " Hey, Bruder." " Moment." "Nein!" "Nein!" "Nein!" "Argyle?" "Mac, you there?" "Hello?" "You know the number." "Use it." "Stay calm." "Everything's going to be fine." "Everything's going to be fine." "Shit!" "Think." "Think." "Ladies and gentlemen." "Ladies and gentlemen." "Due to the Nakatomi Corporation's legacy of greed around the globe... ..they're about to be taught a lesson in the real use of power." "You will be witnesses." "Now... ..where is Mr Takagi?" "Joseph Yashinobo Takagi,... ..born Kyoto, 1937..." "Family emigrated to San Pedro, California, 1939,... ..interned at Manzanar, 1942 to '43,..." "..scholarship student, University of California,... ..1955." "Law degree, Stanford, 1962." "MBA, Harvard, 1970." "President, Nakatomi Trading." "Vice Chairman, Nakatomi lnvestment Group..." "Enough." "And father... ..of five." "I am Takagi." "How do you do?" "It's a pleasure to meet you." "OK, 32... construction, 33... computers." "Nice suit." "John Phillips, London." "I have two myself." "Rumour has it Arafat buys his there." " This way?" " On the left." "And when Alexander saw the breadth of his domain... ..he wept, for there were no more worlds to conquer." "The benefits of a classical education." "Ohh, that's beautiful." "I always enjoyed to make models when I was a boy." "The exactness, the attention to every conceivable detail." "It's beautiful." "Is this what this is all about?" "Our project in Indonesia?" "Contrary to what you people may think,... ..we're going to develop that region, not exploit it." "I believe you." "I read the article in Forbes." "Mr Takagi..." "I could talk about industrialisation and men's fashions all day... ..but I'm afraid work must intrude... ..and my associate here has some questions for you." "Sort offill-in-the-blanks questions, actually." "I don't have that code." "You broke in here to access our computer?" "Any information you could get... ..when they wake up in Tokyo, they'll change it." "You won't be able to blackmail our executives..." "Sit... down!" "Mr Takagi, I'm really not interested in your computer." "But I need the code key... ..because I am interested in the $640 million... ..in negotiable bearer bonds that you have locked in your vault... ..and the computer controls the vault." "You want money?" "What kind ofterrorists are you?" "Who said we were terrorists?" "The bonds represent, at most... ..10 days' operating capital for your parent organisation." "It's really no more than a temporary inconvenience." "Now..." "..the code, please." "It's useless to you." "There are seven safeguards on our vault and the code key's only one of them." "You'll never get it open." "Then there's no reason not to tell it to us." " I told you." " It's not over yet." "It's a very nice suit, Mr Takagi." "It would be a shame to ruin it." "I'm going to count to three." "There will not be a four." "Give me the code." "One,... ..two,..." " ..three,..." " I don't know it." "Get on ajet to Tokyo and ask the chairman." "You're just gonna have to kill me." "OK." "We do it the hard way." "Tony, see ifyou can dispose ofthat." "Karl, you better check on Heinrich's work up on the machine floor." "[bumps head]" "Nothing." "See to Heinrich." "Now... ..you can break the code?" "You didn't bring me for my charming personality." "Argyle, tell me you heard the shots." "You're calling the police right now." "Of course I'm still coming by later." "Sweetheart, have I ever lied to you?" "My boss?" "He thinks I'm on my way to Vegas." "Uli, get up on the pipes." "Marco, you go through here." "I'll throw you the cord." "Hans, we're on the roof." "Here." "Uli." "30 minutes to break the code,... ..two hours, two and a half hours for the five mechanicals, at the minimum." "The 7th lock, however, is out of my hands." "I'm sorry?" "The 7th lock..." "the electromagnetic seal." "You do understand the circuits cannot be cut locally?" "Trust me." "Why the fuck didn't you stop him, John?" "'Cause then you'd be dead, too, asshole." "Think, goddamn it!" "Think!" "We've got a fire alarm." "Call 911." "Give them the guard's name and cancel the alarm." "Then disable the sys..." "Eddie, on what floor did the alarm go off?" "Shall we go?" "Nein." "Yes." "Hello, baby." "Come to Papa." "Come on." "Ah ha ha ha!" "Come on, baby." "Come on, baby." "Come on, baby." "Come to Papa." "I'll kiss your fuckin' Dalmatian." "You stupid motherfuckers!" "No!" "No!" "Turn the fuckin' truck around!" "The fire has been called off, my friend." "No-one is coming to help you." "You might as well come out and join the others." "I promise I won't hurt you." "Drop it, dickhead." "It's the police." "You won't hurt me." "Yeah?" "Why not?" "Because you're a policeman." "There are rules for policemen." "Yeah, that's what my captain keeps telling me." "Bet your ass I wish to proceed." "Nine million terrorists in the world... ..and I got to kill one with feet smaller than my sister." "I wanted this to be professional,... ..efficient, adult, cooperative." "Not a lot to ask." "Alas, your Mr Takagi did not see it that way... ..so he won't be joining us for the rest of his life." "We can go any way you want it." "You can walk out of here or be carried out... ..but have no illusions..." "we are in charge." "So... decide now, each ofyou... ..and please remember..." "..we have left nothing to chance." "It's Tony!" "Get them back!" "Now lhave a machine gun." "Ho... ho... ho." "A security guard we missed?" "They're usually tired old policemen." "No, this is something else." "We have to do something, Hans." "Yes, we do." "Tell Karl his brother is dead." "Tell him to come down." "Karl... komm sofort." "Franco, Fritz, take the body upstairs... ..and out of sight." "I don't want the hostages to think too much." "Komm sofort." "Schnell." "I want blood!" "You'll have it, but let Heinrich plant the detonators... ..and Theo prepare the vault." "After we call the police,... ..you can tear the building apart looking for this man... ..but until then, do not alter the plan!" "And if he alters it?" "What do you think?" "Something's wrong." "Cops?" " John." " John?" "He can fuck this whole thing up." "What does he think he's doing?" "His job." "Bullshit." "His job's 3,000 miles away." "Without him, we still have a chance to get out of here." "Tell that to Takagi." "Mayday, Mayday, anyone copying channel nine." "Terrorists have seized the Nakatomibuilding... ..and are holding at least 30 people hostage." "I repeat." "Unknown number ofterrorists... ..six or more armed with automatic weapons... ..at Nakatomi Plaza,... ..Century City." "Where's the best place to transmit?" "The roof!" "Go!" "Go!" "It's the same address as that fire signal." "I'll handle it." "Attention, whoever you are,... ..this channel is reserved for emergency calls only." "No fucking shit, lady!" "Do lsoundlike I'm ordering a pizza?" "No-one kills him but me." "They have already killed one hostage." "They are fortifying their positions while you're jerking' me off on the radio!" "Sir, I've already told you." "This is a reserved channel." "If this is an emergency call, dial 911 on your telephone." "Otherwise, I'll report this as an FCC violation." "Fine!" "Report me!" "Come the fuck down here and arrest me!" "Just send the police now!" "See if a black and white can drive by." "Thought you guys just ate doughnuts." " They're for my wife." " Yeah." " She's pregnant." " Yeah." "Bag it." "Big time." "Thanks." "Dispatch to 8-Lincoln-30." "Over." "This is 8-Lincoln-30." "Investigate a code two at NakatomiPlaza, Century City." "8-Lincoln-30 to Dispatch." "I'm on my way." "Girls." "Shit!" "Where the fuck is it?" "Oh, my God." "He's in the elevator shaft." "Perfect." "The elevators are locked off." "He can't escape." "Just shut him in and come back down." "Oh, fuck." "Karl, the police are probably on their way... ..already." "Karl?" "Christ." "I can stall them, but not ifthey hear gunshots." "If you lock him in, he'll be neutralised..." ""Come out to the coast!"" ""We'll get together, have a few laughs."" "Now I know what a TV dinner feels like." "Such!" "Karl, komm!" "Die polizei!" "Karl, die polizei!" "Well, it's about time." "No signs of disturbance, Dispatch." "Roger." "Possible crank call." "Check the area again and confirm." "Who's driving this car, Stevie Wonder?" "I do see a guard inside." "I'm gonna go in for a closer look." "Use caution." "Eddie?" "I had a feelin' you'd be calling." "Evenin', officer." "What can I do for you?" "We had that false alarm." "You ask me, that goddamn computer sent you... ..on another wild-goose chase." "They been chasing bugs in this system ever since they installed it." "..Notre Dame on top ofUSC." "Aw, shit!" "I got 50 bucks bet on them assholes." "Come on, come on, where's the fucking cavalry?" "..was goodfor52 yards." "Mind if I look around?" "Help yourself." "27 seconds left in this first period." "Seven to nothing, Notre Dame." "The Irish driving 74yards in eightplays..." "I'll put this fuckin'..." "Freeze, motherfucker!" "Drop it!" "Don't shoot!" " Put the gun down!" " OK!" "Don't shoot!" "Drop that fuckin' gun!" "Marco, down!" "Ah, to hell with this!" "You are done!" "No more table!" "Where are you going, pal?" "Next time you have a chance to kill someone,... ..don't hesitate." "Thanks for the advice." " Sorry to waste your time." " No problem at all." " Merry Christmas." " Merry Christmas to you." "Oh, for the love... 8-Lincoln-30 to Dispatch." "Go ahead." "A wild-goose chase over here at Nakatomi Plaza." "Everything here's OK." "Over." "Shit!" "Goddamn it!" "Jesus H Christ!" "Welcome to the party, pal!" "Goddamn it!" "Get someone here now, goddamn it!" "Policeman under automatic rifle fire at Nakatomi!" "I need backup assistance now!" "Now, goddamn it!" "Now!" "Monica, I can get us a table." "Wolfgang and I are very close friends." "I interviewed him, for God's sake." "..Nakatomi." "Repeat." "Officer needs assistance at..." "I'm at Nakatomi Plaza." "They're turning my car into Swiss cheese!" "I need backup assistance now!" "Now, goddamn it!" "Now!" "Never thought I'd love to hear that sound." "All of you relax." "This is a matter of inconvenient timing, that's all." "Police action was inevitable... ..and, as it happens, necessary." "So, let them fumble about outside and stay calm." "This is simply the beginning." "I told you all I wanted radio silence until..." "I'm very sorry, Hans." "I didn't get that message." "Maybe you shouldhave putit on the bulletin board." "I figured since I waxed Tony and Marco and his friend here,... ..l figured you and Karl and Franco might be lonely... ..so I wanted to give you a call." "How does he know so much about us?" "That's very kind ofyou." "I assume you are our mysterious party crasher." "You are most troublesome... ..for a security guard." "Eeeh!" "Sorry, Hans." "Wrong guess." "Would you like to go for doublejeopardy where the scores can really change?" "Mm, these are very bad for you." "Who are you, then?" "Just the fly in the ointment, Hans." "The monkey in the wrench,... ..the pain in the ass." "Whoa!" "Check on all the others." "Don't use the radio." "See if he's lying about Marco... ..and find out if anyone else is missing." "Mr Mystery Guest,... ..are you still there?" "Yeah, I'm still here... ..unless you want to open the front door for me." "No, I'm afraidnot... ..but you have me at a loss." "You know my name, but who are you?" "Just another American who saw too many movies as a child?" "Another orphan of a bankrupt culture... ..who thinks he's John Wayne, Rambo, Marshal Dillon?" "I was always partial to Roy Rogers, actually." "I liked those sequined shirts." "Do you really think you have a chance against us, Mr Cowboy?" "Yippee-ki-yay, motherfucker." "I'll beat everyone if I get a remote." "Sam, I don't have the new pages." "Harvey, keep your pants on." "Sam, I'm begging you." "Simon's with the remote." "I'll tell him to swing by." "I won't sit on this!" "This is my story!" "I'm going out there!" "Look, Sam." "Tell you what." "You don't give me a truck, I'll steal a truck." "Give us a break, Thornburg." "Eat it, Harvey!" "..four, three, two,... ..one." "Harvey, we're on the air." "Good evening." "This is Harvey Johnson." "And I'm Gail Wallens." "This is Nightline News at 10.00." "Our top stories on this Christmas Eve..." "Take truck number five." "Get out of here." "He wasn't lying about Marco." "He's down on the street." "The other man was Heinrich... ..and his bag is missing." "He had the detonator." "Theo." "Theo." "Yo!" "We mayhave some problems." "How's ourschedule?" "Three down, four to go." "Then don't waste time... ..talking to me." "This is SergeantAIPowell... ..of the Los Angeles Police Department." "If the person who radioed for help... ..can hearme on this channel,... ..acknowledge this transmission." "I say again,... ..if the person who radioed for help can hear me,... ..acknowledge this transmission!" "I read you, pal." "You the guy in the car?" "What's left of him." "Can you identify yourself?" "." "Not now." "Maybe later." "Listen fast." "This is a party line." "The neighbours got itchy trigger fingers." "All right, here's the deal." "You got 30 or so hostages on the 30th floor." "The leader's name is Hans." "We have to find him and shut him up." "He's telling them everything!" "Let him." "I'm waiting for the fbi." "He can waste as much time as he likes... ..but we must find the bag, Fritz." "They have a freakin'arsenalhere." "We must have the detonators." "They got missiles, automatic weapons,... ..and enough plastic explosives to orbit Arnold Schwarzenegger." "They're down to nine now, counting the skydiver you met." "These guys are mostly European... ..judging by their clothing labels and..." "..cigarettes." "They're well-financed and very slick." "How do you know that?" "I've seen enough phoney IDs in my time... ..to recognise the ones they got must have cost a fortune." "Add all that up." "I don't know what the fuck it means... ..but you got some bad-ass perpetrators... ..and they're here to stay." "I hear you, partner." "LA's finest are on it,... ..so light 'em if you got 'em." "Way ahead of you, partner." "So what do I call you?" "Call me... ..Roy." "Listen up, Roy, if you think of anything else... ..don't be shy, OK?" "In the meantime, find a safe place and let us do our job." "They're all yours, Al." "Who's talking to 'em?" "I am, sir." "Sergeant Powell." "AI Powell." "Dwayne Robinson." "What's the deal?" "What do these pricks want?" "If you mean the terrorists,... ..we haven't heard a peep from them." "Who have you been talking to?" "We don't know." "He won't give us his name." "But he appears to be the one who phoned." "He's killed one terrorist for sure and claims he capped off two others." "He claims?" "Powell, has it occurred to you... ..he could be one ofthe terrorists pulling your chain... ..or some nutcase in there?" "I don't think so." "In fact, I think he's a cop,... ..maybe not LAPD, But he's definitely a badge." " How do you know that?" " A hunch... things he said... ..like being able to spot a phoney ID." "Jesus Christ, Powell!" "He could be a fucking bartender for all we know!" "TV's here." "Oh, shit." "I have a request." "What idiot put you in charge?" "You did... ..when you murdered my boss." "Now everybody's looking to me." "Personally, I'd pass on the job." "I don't enjoy being this close to you." "Go on." "We have a pregnant woman." "Relax." "She's not due for a couple weeks... ..but sitting on that rock isn't doing her back any good." "So I'd like permission to move her to an office with a sofa." "No, but I'll have a sofa brought out." "Good enough?" "Good enough." "And unless you like it messy,... ..start bringing us in groups to the bathroom." "Yes." "You're right." "It will be done." "Was there something else?" "No, thank you." "Mr Takagi chose his people well, Mrs...?" "Gennero." "Ms Gennero." "We interrupt this programme for a special news bulletin." "This is Richard Thornburg live from Century City." "Tonight, Los Angeles hasjoined the sadand worldwide fraternity ofcities whose only membership requirement is to suffer the anguish of international terrorism." "Approximately two hours ago, an unidentified group of men seized control of the Nakatomi building, sealing off all entrances and exits." "All telephone lines have been cut and the only communication now possible has been through the use of CB communicators which the group apparently brought with them." "According to official sources, the perpetrators of this building siege..." "Unit five, hold your position in the main entrance." "We got Charlie unit in position by the parking structure." "Let me ask you something." "Does this stairway go up to the escalator?" "Yeah." "Tell them to go ahead." "What's going on?" "What's it look like?" "We're going in." "Going in?" "Man, that's crazy!" "There could be over 30 hostages in there for all we know." "We don't know shit, Powell." "If there's hostages, how come there were no ransom demands?" "If there's terrorists in there, where's their list of demands?" "All we know is that somebody shot your car up." "It's probably the same silly son of a bitch you've been talking to on that radio." "Excuse me, sir, but what about the body that fell out the window?" "Probably some stockbroker got depressed." "We're ready, Chief." " Light 'em up." "Let's go." " Hit your lights." " Blue units, go." " Lights on!" "Powell?" "Powell, you still with me, babe?" "What's going on?" "Yo, Al." "I'm here, Roy, but I'm kind of busy right now." "I'll talk to you later." "Al, what's wrong?" "I'll talk to you later." "If you are what I think you are, you'll know when to listen, shut up, and" "and when to pray." "Jesus Christ!" "You're coming in, right?" "Christ, Powell," "I told you what kind of people you're dealing with here." "Let's load them up." "They'll be coming." "Everyone get ready." "Theo, you are the eyes now." " Rivers." " Yo." "Begin your reconnoitre." "Let's go." "Shit!" "Come on." "Let's go." "Ow!" "Jesus!" "All right, spread out." "Shut up." "Let's go." "You macho assholes." "No!" "No!" "Ahem... all right." "Listen up, guys." "'Twas the night before Christmas and all through the house not a creature was stirring, except the four assholes coming in the rear in standard two-by-two cover formation." "We're all set." "We're ready." "Kick ass." "Go!" "Right." "Let's do it." "Take cover!" "They're shooting at 'em." "It's panic fire." "They can't see anything." "They're shooting at the lights." "They're going after the lights." "Call them back." "It's not happening." "Mike, burn it." "Don't be impatient." "Just wound them." "Get them back." "They're sitting ducks without lights." "They're almost in." "Send in the car." "Send in the car." "Jesus Christ!" "Rivers, Rodriguez, report." "Wait a minute." "What have we here, gentlemen?" "The police have themselves an RV." "Southeast corner." "Oh, Jesus Christ." "Get back!" "Get the fuck back!" "Get over there." "Schnell!" "Schnell!" "Mach schnell!" "Weiter!" "Weiter!" "Weiter!" "Mach schnell!" "Mach schnell!" "Weiter!" "Mach los!" "Mach los!" "I see him!" " Fire!" " Clear!" "Oh, my God!" "The quarterback is toast!" "Hang on, Rivers." "That's an order." "Hit it again." "All right, you motherfucker, you made your point!" "Let them pull back!" "Thank you, Mr Cowboy." "I'll take it under advisement." "Hit it again." "Fire." "Fuck me." "Get them out of the car!" "They're burning!" "Fuck it." "Mach schnell!" "Mach los!" "Let's see you take this under advisement, jerkweed." "Geronimo, motherfucker." "Oh, shit!" "They're using artillery on us!" "You idiot, it's not the police." "It's him." "Holy shit." "My God!" " Tell me you got that." " I got it." "Eat your heart out, Channel Five." "We've had an update on the terrorist take over of the Nakatomi building." "Sources say the terroristleader, Hans, may be this man..." "Hans Gruber." "A member ofthe radical West German Volksfreimovement." "Strangely, the Volksfrei leadership issued a communiqué an hour ago stating that Gruber had been expelled from that organisation." "Al, do you copy?" "Are you all right?" "Yeah, I'm fine." "W-what was that?" "Remember that plastic explosive I told you about?" "There you go." "Is the building on fire?" "No, but it's gonna need a paint job and a shitload of screen doors." "Our spotter said you got two with that blast." " Is that him?" " Yes, sir." "I don't know who you think you are but you just destroyed a building." "We do not want your help." "Is that clear?" "We don't want your help." "I've got 100 people down here, and they're covered with glass." "Glass?" "Who gives a shit about glass?" "Who the fuck is this?" "This is Deputy Chief of Police Dwayne T Robinson and I am in charge of this situation." "Oh, you're in charge?" "I got some bad news for you, Dwayne." "From up here it doesn'tlook like you're in charge ofshit." "Listen to me, you little asshole..." "Asshole?" "I'm not the one who just got butt fucked on national TV, Dwayne." "Ah ha ha!" "Listen to me,jerk-off, if you're not part of the solution, you're part of the problem." "Quit being part of the problem and put the other guy back on!" "Hey, Roy, how you feeling?" "Pretty fucking unappreciated, Al." "Hey, look." "I love you." "So do a lot of the otherguys." "So hang in there, man, you hear me?" "You hang in there." "Yeah, thanks, partner." "What are you doing?" "I'm tired of sitting here waiting to see who gets us killed first, them or your husband." "What are you going to do?" "Hey, babe," "I negotiate million-dollar deals for breakfast." "I think I can handle this Eurotrash." "Hey, sprechen sie talk, huh?" "If you'd listened to me, he would be neutralised already." "I don't want neutral." "I want dead." "Hope I'm not interrupting." "What does he want?" "It's not what I want." "It's what I can give you." "Look, let's be straight, OK?" "It's obvious you're not some dumb schmuck up here to snatch a few purses." "You're very perceptive." "I watch 60 Minutes." "I say to myself, these guys are professional, they're motivated, they're happening, they want something." "I couldn't care less about your politics." "Maybe you're pissed off at the camel jockeys." "Maybe it's the Hebes, Northern lreland." "It's none of my business." "I figure you're here to negotiate, am I right?" "You're amazing." "You figured this all out already?" "Hey, business is business." "You use a gun, I use a fountain pen." "What's the difference?" "Let's put it in my terms." "You're here on a hostile takeover." "You grab us for some green but you didn't expect some poison pill was gonna be running around the building." "Am I right?" "Hans, bubble..." "I'm your white knight." "I must have missed 60 Minutes." "What are you saying?" "The guy upstairs who's fucking things up, huh?" "I can give him to you." "Oh, God..." "Roy?" "Roy, you all right?" "Just trying to fire down a 1,000-year-old Twinkie." "What do they put in these things, anyway?" "Sugar, enriched flour, partially hydrogenated vegetable oil, polysorbate 60, and yellow dye number five." "Just everything a growing boyneeds." "How many kids you got, Al?" "As a matter of fact, my wife is working on our first." "How about you, cowboy?" "You got any kids back on your ranch?" "Yeah." "Two." "Sure hope I can see them swinging on ajungle gym with AI Jnr someday." "Well, now, that's a date but you bring the ice cream." "Touching, cowboy." "Touching." "Or shouldl call you" "Mr McClane?" "Mr Officer John McClane of the New York Police Department?" "Get on the phone to Harry in New York." "You better get a hold of somebody at Dispatch." "Sister Theresa called me Mr McClane in the third grade." "My friends call me John and you're neither, shithead." "I have someone who wants to talk to you." "A very special friend who was with you at the party tonight." "Hey, John boy." "Ellis?" "Yeah." "Listen, John, they're giving me a few minutes to talk sense into you." "I know you think you're doing yourjob and I can appreciate that but you'rejust dragging this thing out." "Look, no-one gets out of here until these guys can talk to the LA Police." "That won't happen until you stop messing up the works." "Capisce?" "Ellis, what have you told them?" "I told them we were old friends and you were my guest at the party." "Ellis, you shouldn't be doing this." "Tell me about it." "All right, John, listen." "They want you to tell them where the detonators are." "They know people are listening." "They want the detonators, or they're gonna kill me." "John, didn't you hear me?" "Yeah, I hear you." "John, get with the programme." "The police are here now." "It's their problem." "Tell these guys where the detonators are so no-one else gets hurt!" "I'm putting my life on the line for you, pal!" "Ellis, listen to me carefully." "John..." "Shut up, Ellis!" "Just shut your mouth!" "Put Hans back on the line." "Hans, this shithead doesn'tknow what kind of man you are but I do." "Good." "Then you'll give us what we want and save your friend's life." "You're not part ofthis equation." "Hey, what am I, a method actor?" "Babe, putaway the gun." "This is radio, not television." "Hans, this asshole is not my friend!" "I just met him tonight!" "I don't know him!" "Jesus Christ, Ellis!" "These people will kill you!" "Tell them you don't know me!" "How can you say that after all these years?" "John?" "John?" "Do you hear that?" "Talk to me!" "Where are my detonators?" "Where are they, or shall I shoot another one?" "Sooner or later" "I mightget to someone you do care about." "Go fuck yourself, Hans." "He just let the guy die." "He just gave him up." "Give me that headset." "That's like pulling the trigger yourself." "Can't you see what's happening?" "Can't you read between the lines?" "He did everything he could to save him." "If he gave himself up, they'd both be dead right now!" "No way, man." "They'd be talking to us." "You tell this partner of yours to stay out of this from now on." "Because if he doesn't, I'm really going to nail his ass." "The man is hurting." "He is alone, tired, and he hasn't seen diddly-squat from anybody here!" "You're gonna tell me he'll give a damn about what you do to him if he makes it out ofthere alive?" "Why don't you wake up and smell what you're shovelling?" "You listen to me, sergeant." "Any time you want to go home, you consider yourself dismissed." "No, sir." "You couldn't drag me away." "Attention, police." "Attention, police." " This is Sergeant AI Powell..." " Give me that." "This is Deputy Chief Dwayne Robinson." "Who is this?" "This is Hans Gruber." "I assume you realise the futility of direct action against me." "We have no wish for further loss of life." "What is it you do wish for?" "I have comrades in arms around the world languishing in prison." "The American State Department enjoys rattling its sabre for its own ends." "Now it can rattle it for me." "The following people are to be released from their captors." "In Northern lreland the seven members of the New Provo Front." "In Canada, the five imprisonedleaders ofLiberté de Quebec." "In Sri Lanka, the nine members of the Asian Dawn." "What the fuck?" "Asian Dawn?" "I read about them in Time magazine." "When these revolutionary brothers and sisters are free, the hostages in this building will be taken to the roof and they will accompany us in helicopters to the Los Angeles International Airport where they will be given further instructions." "You have two hours to comply." "Wait a minute." "Uh, Mr. Gruber." "This is crazy." "I don't have the authority." "Two hours is not enough." "Hello?" "Hello!" "Did you get all that?" "We got to make some calls." "Do you think they'll even try?" "Who cares?" "Theo, are we on schedule?" "One more to go, then it's up to you." "You better be right because the last one will take a miracle." "It's Christmas, Theo." "It's the time of miracles, so be of good cheer and call me when you hit the last lock." "Karl, hunt that little shit down and get those detonators." "Fritz is checking the explosives." "I'll check the explosives." "You just get the detonators." "Hey, Powell, you out there?" "I'm here, John." "I'm here." "You gotta believe me." "There was nothing I could do." "Well, it's gonna be both our asses ifyou're wrong." "I hear you." "Did you catch that bullshit Hans was running?" "It doesn'tmake sense, man." "Hey, don't ask me, man." "I'm just a deskjockey who was on my way home when you rang." "The way you drove that car I figured you for the street, Al." "In my youth." "In my youth." "..author of "Hostage Terrorist, Terrorist Hostage," "A Study in Duality. "" "Dr Hasseldorf, what can we expect in the next few hours?" "Well, Gail, by this time, the hostages should be going through the early stages of the Helsinki Syndrome." "As in Helsinki, Sweden." "Finland." "Basically, it's when the hostages and the terrorists go through a sort of psychological transference and a projection of dependency." "A strange sort oftrust and bond develops." "We've hadsituations where the hostages have embraced their captors after release and even corresponded with them in prison." "No, no, darling." "Asian Dawn." "Dawn." "D-A-W-N." " Sir?" " Yeah?" "Sir, the FBI is here." " The FBI is here now?" " Yes, sir." "Right over there." "Hold this." "Want a breath mint?" "Hey, how you doing, man?" "I'm Agent Johnson." "This is Special Agent Johnson." " Oh, how you doing?" " No relation." "I'm, uh..." "I'm Dwayne Robinson, LAPD." "I'm in charge here." "Not any more." "Hi, there." "How you doing?" "Ohh..." "Please, God." "No." "You're one ofthem, aren't you?" "You're one ofthem." "No!" "Don't kill me!" "Please!" "Don't kill me, please!" "Please, please, please." "Whoa." "Relax." "I'm not gonna hurt you." "I'm not gonna hurt you!" "Oh, God." "What the fuck are you doing up here?" "What were you looking for?" "I managed to get out ofthere and" "I was just trying to get up on the roof and see if I could signal for help." "It's just over here." "Why don't you come and help?" "Hold it." "Forget the roof." "I said forget the roof." "They got people all over it." "You want to stay alive, you stay with me." "The best we can figure it, we've got maybe 30 or 35 hostages up there probably on the 30th floor and maybe seven or eight terrorists up there." "Sounds like an A-7 scenario." "Thank you." "We'll handle it from here." "When we commandeer your men, we'll try and let you know." "Aren't you forgetting something?" "Such as?" "What about John McClane?" "He's the reason we have any information." "He's also the reason you're facing seven terrorists, not twelve." "He's inside?" "Who is he?" "He might be a cop." "We're checking on that." " One ofyours?" " No, no way." "You smoke?" "Yeah." "Thanks." "You don't work for Nakatomi." "And ifyou're not one ofthem..." "I'm a cop from New York." "New York?" "Yeah." "Got invited to the Christmas party by mistake." "Who knew?" "Better than being caught with your pants down, huh?" "I'm John McClane." "You're, uh..." "Clay." "Bill Clay." "Know how to use a handgun, Bill?" "I spent a weekend at a combat ranch." "That game with the guns that shoot red paint." "Probably seems kind of stupid to you." "Nope." "Time for the real thing, Bill." "All you got to do is pull the trigger." "Come on." "Put down the gun and give me my detonators." "Well, well, well..." "Hans." "Put it down now." "That's pretty tricky with that accent." "You oughta be on fucking TV with that accent." "But what do you want with the detonators?" "I already used all the explosives." "Or did I?" "I'm going to count to three." "Yeah." "Like you did with Takagi?" "Oops." "No bullets." "What do you think..." "I'm fucking stupid, Hans?" "You were saying?" "Karl." "SchieB dem Fenster." "Shoot the glass!" "Jesus Christ!" "Smile, Karl." "We're back in business." "..is the lastresort ofdiplomacy, then couldn't wejustas well say that terrorism has an equal claim on being that, too?" "Tell me you got something." "McClane's name, badge number, employment record, vital statistics, and his family's home address right here in LA." "Whoo!" "Go to work." "Got it." "God, that man looks really pissed." "He's still alive." "What?" "Only John can drive somebody that crazy." "Hans, you better heat up that miracle because we just broke through on number six and the electromagnetic came down like a fucking anvil." "Have a look at what our friends outside are doing and I'll be right up." "Hey, John." "John McClane, you still with us?" "Yeah." "But all things being equal, I'd rather be in Philadelphia." "Chalk up two more bad guys." "The boys down here will be glad to hear that." "We gota poolgoing on you." "What kind of odds am I getting?" "You don't want to know." "Put me down for 20." "I'm good for it." "Hey, pal, you gotflatfeet?" "What the hell are you talking about, man?" "Something had to get you offthe street." "What's the matter?" "You don't thinkjockeyingpapers across a desk is a noble effortfora cop?" "No." "I had an accident." "The wayyou drive, I can see why." "What'd you do ?" "Run over your captain's foot with the car?" "I shot a kid." "He was 13 years old." "Oh, it was dark." "I couldn'tsee him." "He hada raygun, lookedreal enough." "When you're a rookie, they teach you everything about being a cop except how to live with a mistake." "Anyway, ljust couldn'tbring myself to drawmygun on anybody again." "Sorry, man." "Hey, man, how could you know?" "I feel like shit anyway." "Well, then, this won't matter." "The LAPD is not calling the shots down here any more." "The Feds?" "You got it." "Those are the city engineers." "Wait." "They're going into the street circuits." "Those guys in the suits, I don't know who they are." "That's the fbi." "They're ordering the others to cut the building's power." "Regular as clockwork." "Or a time lock." "Precisely." "The circuits that cannot be cut are cut automatically in response to a terrorist incident." "You asked for miracles, Theo." "I give you the F-B-l." "I want the building shut down." "I got a problem." "I got a switch..." "I don't care about your switch." "I want it out." "Dark!" "You can't do it from here." " Yeah, you could." " It can't be done from here." "I could just..." "I got the radio..." "You can't do it from here." "It's got to be done from downtown." "They've gotta take out a whole city grid." "We're talking 10 square blocks." "Ten blocks?" "Johnson, that's crazy." "It's Christmas Eve." "There's thousands of people." "You have to go wider." " I need authorisation." " How about the United States government?" "Lose the grid, or you lose yourjob." " Yeah, Central?" " Yeah?" "This is Walt down at Nakatomi." "Would it be possible for you to turn off grid 212?" "Are you crazy?" "!" "Maybe I should call the Mayor." "No shit it's my ass." "I got a big problem here." "Shut it down now." "Emergency lighting activated." "Al, talk to me." "What's going on here?" "Ask the fbi." "They got the universal terrorist playbook and they're running it step by step." "It's gonna go." "It's gonna go!" "Yes!" "Merry Christmas." "They must be pissing in their pants." "The Mayor is gonna have my ass." "Whoo!" "What are we gonna do now ?" "Arrest them for not paying their electric bill?" "We've shut them down." "We let them sweat for a while, then we give them helicopters." "Right up the ass." "This is Agent Johnson." "No, the other one." "I want that air support ready to lift off in five minutes." "Damn right." "Fully armed." "We're on the way." "Oh, yes!" "I wish to talk to the fbi." "This is Special Agent Johnson." "The State Departmenthas arranged for the return ofyour comrades." "Helicopters are en route as you requested." "I hearyou." "We'll be ready." "By the time he figures out what hit him, he'll be in a body bag." "When they touch down, we'll blow the roof." "They'll spend a month sifting through the rubble." "By the time they figure out what went wrong, we'll be sitting on a beach earning 20%." "Ah!" "Jeez!" "Powell?" "Yo, Powell, you got a minute?" "I'm here, John." "Listen, I'm starting to get a bad feeling up here." "I want you to do something for me." "Um... ahem..." "I want you to find my wife." "Don't ask me how." "By then you'll know how." "Uh, I want you to tell her something." "I want you to tell her that..." "Tell her it took me a while to figure out what ajerk I've been but, um... that... that when things started to pan out for her" "I should have been more supportive." "And, uh..." "Ijustshouldhave been behind hermore." "Oh, shit." "Tell her that, um that she's the best thing that ever happened to a bum like me." "She's heard me say "l love you" a thousand times." "She never heard me say I'm sorry." "I want you to tell her that, Al." "Tell her that John said that he was sorry." "OK?" "You got that, man?" "Yeah, lgotit, John." "But you can tell her that yourself." "You just watch your ass and you'll make it out." "You hear me?" "I guess that's up to the man upstairs." "John?" "John?" "What the fuck were you doing upstairs, Hans?" "John?" "No, Al, listen." "Just lay offfor a while." "I gotta go check on something." "One minute, that's all I'm asking." "One minute to speak to them." "All right." "Get back." "Get back." "All right, look." "You let me in right now, or I call the INS, comprende?" "This is the last time these kids are gonna have to speak to their parents." "All right?" "All right." "Come on." "Come on." "What were you doing, Hans?" "What were you doing?" "Jesus, Mary, mother of God." "Al, listen to me!" "It's a double-cross!" "The roof is wired to..." "John?" "John!" "John, come in!" "Did you get that?" "Something about a double-cross." "Tell me about it." "We are both professionals." "This is personal." "Aww..." "They're coming!" "Choppers are coming." "Time to gather your flock, Miss Gennero." "Your mom and dad are veryimportantpeople." "They're verybrave people." "Is there somethingyou'dlike to say to them, ifthey're watching?" "Come home." "Mrs McClane." "How nice to make your acquaintance." "On your feet, everyone!" "To the roof!" "Lock them up there and come right back." "You should have heard your brother squeal when I broke his fucking neck!" "What do you figure the breakage?" "I figure we take out the terrorists," "lose 20, 25% ofthe hostages, tops." "I can live with that." "Get this thing on the deck." "They're expecting transports, not gun ships." "Move it!" "Come on!" "Move!" "Come on!" "Come on!" "Move it!" "Go!" "Move!" "Theo." "A little bonus for us." "Please, sit down." "Sit down!" "A policeman's wife might come in handy." "McClane, I have some news for you." "McClane?" "Move!" "Come on!" "Motherfucker!" "I'll kill you!" "Armed." " The truck?" " The truck." "After all your posturing, all your little speeches, you're nothing but a common thief." "I am an exceptional thief, Mrs McClane." "And since I'm moving up to kidnapping, you should be more polite." "You motherfucker, I'm gonna kill you!" "I'm gonna fuckin' cook you, and I'm gonna fuckin' eat you!" "I don't like this, Sarge." "Yee-hah!" "Just like fucking Saigon, eh, Slick?" "I was in Junior High, dickhead." "Where's Holly?" "Where's Holly Gennero?" "Holly Gennero?" "Where's Holly?" "Where's Holly?" "Where is she?" " They took her!" " Where?" "The vault!" " Where is the vault?" " The 30th floor!" "They just took her!" "Get downstairs!" "The whole fucking roof is wired to blow!" "Get down!" "Get down!" "Get the fuck downstairs!" "They made us, Bureau." "Terrorist shooting hostages." "Break left!" "Nail that sucker!" "I'm on your side, you assholes!" "Swing around again!" "I'll bag this little bastard." "What the fuck..." "Oh, John, what the fuck are you doing?" "How the fuck did you get into this shit?" "There's something wrong!" "They're coming back down!" " Blow the roof." " But Karl's up there!" "Blow the roof!" "I promise I will never even think about going up in a tall building again." "Oh, God, please don't let me die!" "Holy Christ!" "We're gonna need some more FBI guys, I guess." "Jesus fucking Christ!" "Fuck!" "What the fuck is going on?" "What are you gonna do?" "Sit here while the building falls down?" "Shit!" "All right!" "Hey!" "Hey!" "Hang on, baby." "Hang on, honey." "Oh, God." "Hans!" "Jesus." "Hi, honey." "So that's what this is all about?" "A fucking robbery?" "Put down the gun." "Why'd you have to nuke the whole building, Hans?" "Well, when you steal $600, you can just disappear." "When you steal 600 million, they will find you unless they think you're already dead." "Put down the gun." "Nein." "This is mine." "You got me." "Still the cowboy, Mr McClane." "Americans... all alike." "This time, John Wayne does not walk off into the sunset with Grace Kelly." "That was Gary Cooper, asshole." "Enough jokes." "You'd have made a pretty good cowboy yourself, Hans." "Oh, yes." "What was it you said to me before?" "Yippee-ki-yay, motherfucker." "Holly!" "Happy trails, Hans." " Aah!" " Holly." "I hope that's not a hostage." "Gimme water hook-ups for engine companies 5, 3, 9, 6." "Over here." "It's a better angle." "Let's give them a hand." "Keep it going, now." "Keep it going." " Come on." "We're going to miss it!" " OK." "Hand me my notes!" "What was it like in there?" "How did they treat you?" "Al, this is my wife Holly." "Holly Gennero." "Holly McClane." "Hello, Holly." "You got yourself a good man." "You take good care of him." "McClane!" "McClane, I want a debriefing!" "You got some things to answer for, mister." "Ellis' murder, for one thing." "Property damage, interfering with police business." "Two ofyou go inside and see ifthere's anybody else!" "No." "This one's with me." "Mr McClane, Mr McClane!" "Now that it's all over, after this incredible ordeal, what are your feelings?" "Well, well, well." " Merry Christmas, Argyle." " Merry Christmas." "Did you get that?" "Let me through." "If this is their idea of Christmas, I gotta be here for New Year's." "I'm here, Roy, but I'm kind of busy right now." "I'll talk to you later." "Al, what's wrong?" "I'll talk to you later." "If you are what I think you are, you'll know when to listen, shut up, and" "and when to pray." "Jesus Christ!" "You're coming in, right?" "Christ, Powell," "I told you what kind of people you're dealing with here." "Let's load them up." "They'll be coming." "Everyone get ready." "Theo, you are the eyes now." " Rivers." " Yo." "Begin your reconnoitre." "Let's go." "Shit!" "Come on." "Let's go." "Ow!" "Jesus!" "All right, spread out." "Shut up." "Let's go." "You macho assholes." "No!" "No!" "Ahem... all right." "Listen up, guys." "'Twas the night before Christmas and all through the house not a creature was stirring, except the four assholes coming in the rear in standard two-by-two cover formation." "We're all set." "We're ready." "Kick ass." "Go!" "Right." "Let's do it." "Take cover!" "They're shooting at 'em." "It's panic fire." "They can't see anything." "They're shooting at the lights." "They're going after the lights." "Call them back." "It's not happening." "Mike, burn it." "Don't be impatient." "Just wound them." "Get them back." "They're sitting ducks without lights." "They're almost in." "Send in the car." "Send in the car." "Jesus Christ!" "Rivers, Rodriguez, report." "Wait a minute." "What have we here, gentlemen?" "The police have themselves an RV." "Southeast corner." "Oh, Jesus Christ." "Get back!" "Get the fuck back!" "Get over there." "Schnell!" "Schnell!" "Mach schnell!" "Weiter!" "Weiter!" "Weiter!" "Mach schnell!" "Mach schnell!" "Weiter!" "Mach los!" "Mach los!" "I see him!" " Fire!" " Clear!" "Oh, my God!" "The quarterback is toast!" "Hang on, Rivers." "That's an order." "Hit it again." "All right, you motherfucker, you made your point!" "Let them pull back!" "Thank you, Mr Cowboy." "I'll take it under advisement." "Hit it again." "Fire." "Fuck me." "Get them out of the car!" "They're burning!" "Fuck it." "Mach schnell!" "Mach los!" "Let's see you take this under advisement, jerkweed." "Geronimo, motherfucker." "Oh, shit!" "They're using artillery on us!" "You idiot, it's not the police." "It's him." "Holy shit." "My God!" " Tell me you got that." " I got it." "Eat your heart out, Channel Five." "We've had an update on the terrorist take over of the Nakatomi building." "Sources say the terroristleader, Hans, may be this man..." "Hans Gruber." "A member ofthe radical West German Volksfreimovement." "Strangely, the Volksfrei leadership issued a communiqué an hour ago stating that Gruber had been expelled from that organisation." "Al, do you copy?" "Are you all right?" "Yeah, I'm fine." "W-what was that?" "Remember that plastic explosive I told you about?" "There you go." "Is the building on fire?" "No, but it's gonna need a paint job and a shitload of screen doors." "Our spotter said you got two with that blast." " Is that him?" " Yes, sir." "I don't know who you think you are but you just destroyed a building." "We do not want your help." "Is that clear?" "We don't want your help." "I've got 100 people down here, and they're covered with glass." "Glass?" "Who gives a shit about glass?" "Who the fuck is this?" "This is Deputy Chief of Police Dwayne T Robinson and I am in charge of this situation." "Oh, you're in charge?" "I got some bad news for you, Dwayne." "From up here it doesn'tlook like you're in charge ofshit." "Listen to me, you little asshole..." "Asshole?" "I'm not the one who just got butt fucked on national TV, Dwayne." "Ah ha ha!" "Listen to me,jerk-off, if you're not part of the solution, you're part of the problem." "Quit being part of the problem and put the other guy back on!" "Hey, Roy, how you feeling?" "Pretty fucking unappreciated, Al." "Hey, look." "I love you." "So do a lot of the otherguys." "So hang in there, man, you hear me?" "You hang in there." "Yeah, thanks, partner." "What are you doing?" "I'm tired of sitting here waiting to see who gets us killed first, them or your husband." "What are you going to do?" "Hey, babe," "I negotiate million-dollar deals for breakfast." "I think I can handle this Eurotrash." "Hey, sprechen sie talk, huh?" "If you'd listened to me, he would be neutralised already." "I don't want neutral." "I want dead." "Hope I'm not interrupting." "What does he want?" "It's not what I want." "It's what I can give you." "Look, let's be straight, OK?" "It's obvious you're not some dumb schmuck up here to snatch a few purses." "You're very perceptive." "I watch 60 Minutes." "I say to myself, these guys are professional, they're motivated, they're happening, they want something." "I couldn't care less about your politics." "Maybe you're pissed off at the camel jockeys." "Maybe it's the Hebes, Northern lreland." "It's none of my business." "I figure you're here to negotiate, am I right?" "You're amazing." "You figured this all out already?" "Hey, business is business." "You use a gun, I use a fountain pen." "What's the difference?" "Let's put it in my terms." "You're here on a hostile takeover." "You grab us for some green but you didn't expect some poison pill was gonna be running around the building." "Am I right?" "Hans, bubble..." "I'm your white knight." "I must have missed 60 Minutes." "What are you saying?" "The guy upstairs who's fucking things up, huh?" "I can give him to you." "Oh, God..." "Roy?" "Roy, you all right?" "Just trying to fire down a 1,000-year-old Twinkie." "What do they put in these things, anyway?" "Sugar, enriched flour, partially hydrogenated vegetable oil, polysorbate 60, and yellow dye number five." "Just everything a growing boyneeds." "How many kids you got, Al?" "As a matter of fact, my wife is working on our first." "How about you, cowboy?" "You got any kids back on your ranch?" "Yeah." "Two." "Sure hope I can see them swinging on ajungle gym with AI Jnr someday." "Well, now, that's a date but you bring the ice cream." "Touching, cowboy." "Touching." "Or shouldl call you" "Mr McClane?" "Mr Officer John McClane of the New York Police Department?" "Get on the phone to Harry in New York." "You better get a hold of somebody at Dispatch." "Sister Theresa called me Mr McClane in the third grade." "My friends call me John and you're neither, shithead." "I have someone who wants to talk to you." "A very special friend who was with you at the party tonight." "Hey, John boy." "Ellis?" "Yeah." "Listen, John, they're giving me a few minutes to talk sense into you." "I know you think you're doing yourjob and I can appreciate that but you'rejust dragging this thing out." "Look, no-one gets out of here until these guys can talk to the LA Police." "That won't happen until you stop messing up the works." "Capisce?" "Ellis, what have you told them?" "I told them we were old friends and you were my guest at the party." "Ellis, you shouldn't be doing this." "Tell me about it." "All right, John, listen." "They want you to tell them where the detonators are." "They know people are listening." "They want the detonators, or they're gonna kill me." "John, didn't you hear me?" "Yeah, I hear you." "John, get with the programme." "The police are here now." "It's their problem." "Tell these guys where the detonators are so no-one else gets hurt!" "I'm putting my life on the line for you, pal!" "Ellis, listen to me carefully." "John..." "Shut up, Ellis!" "Just shut your mouth!" "Put Hans back on the line." "Hans, this shithead doesn'tknow what kind of man you are but I do." "Good." "Then you'll give us what we want and save your friend's life." "You're not part ofthis equation." "Hey, what am I, a method actor?" "Babe, putaway the gun." "This is radio, not television." "Hans, this asshole is not my friend!" "I just met him tonight!" "I don't know him!" "Jesus Christ, Ellis!" "These people will kill you!" "Tell them you don't know me!" "How can you say that after all these years?" "John?" "John?" "Do you hear that?" "Talk to me!" "Where are my detonators?" "Where are they, or shall I shoot another one?" "Sooner or later" "I mightget to someone you do care about." "Go fuck yourself, Hans." "He just let the guy die." "He just gave him up." "Give me that headset." "That's like pulling the trigger yourself." "Can't you see what's happening?" "Can't you read between the lines?" "He did everything he could to save him." "If he gave himself up, they'd both be dead right now!" "No way, man." "They'd be talking to us." "You tell this partner of yours to stay out of this from now on." "Because if he doesn't, I'm really going to nail his ass." "The man is hurting." "He is alone, tired, and he hasn't seen diddly-squat from anybody here!" "You're gonna tell me he'll give a damn about what you do to him if he makes it out ofthere alive?" "Why don't you wake up and smell what you're shovelling?" "You listen to me, sergeant." "Any time you want to go home, you consider yourself dismissed." "No, sir." "You couldn't drag me away." "Attention, police." "Attention, police." " This is Sergeant AI Powell..." " Give me that." "This is Deputy Chief Dwayne Robinson." "Who is this?" "This is Hans Gruber." "I assume you realise the futility of direct action against me." "We have no wish for further loss of life." "What is it you do wish for?" "I have comrades in arms around the world languishing in prison." "The American State Department enjoys rattling its sabre for its own ends." "Now it can rattle it for me." "The following people are to be released from their captors." "In Northern lreland the seven members of the New Provo Front." "In Canada, the five imprisonedleaders ofLiberté de Quebec." "In Sri Lanka, the nine members of the Asian Dawn." "What the fuck?" "Asian Dawn?" "I read about them in Time magazine." "When these revolutionary brothers and sisters are free, the hostages in this building will be taken to the roof and they will accompany us in helicopters to the Los Angeles International Airport where they will be given further instructions." "You have two hours to comply." "Wait a minute." "Uh, Mr. Gruber." "This is crazy." "I don't have the authority." "Two hours is not enough." "Hello?" "Hello!" "Did you get all that?" "We got to make some calls." "Do you think they'll even try?" "Who cares?" "Theo, are we on schedule?" "One more to go, then it's up to you." "You better be right because the last one will take a miracle." "It's Christmas, Theo." "It's the time of miracles, so be of good cheer and call me when you hit the last lock." "Karl, hunt that little shit down and get those detonators." "Fritz is checking the explosives." "I'll check the explosives." "You just get the detonators." "Hey, Powell, you out there?" "I'm here, John." "I'm here." "You gotta believe me." "There was nothing I could do." "Well, it's gonna be both our asses ifyou're wrong." "I hear you." "Did you catch that bullshit Hans was running?" "It doesn'tmake sense, man." "Hey, don't ask me, man." "I'm just a deskjockey who was on my way home when you rang." "The way you drove that car I figured you for the street, Al." "In my youth." "In my youth." "..author of "Hostage Terrorist, Terrorist Hostage," "A Study in Duality. "" "Dr Hasseldorf, what can we expect in the next few hours?" "Well, Gail, by this time, the hostages should be going through the early stages of the Helsinki Syndrome." "As in Helsinki, Sweden." "Finland." "Basically, it's when the hostages and the terrorists go through a sort of psychological transference and a projection of dependency." "A strange sort oftrust and bond develops." "We've hadsituations where the hostages have embraced their captors after release and even corresponded with them in prison." "No, no, darling." "Asian Dawn." "Dawn." "D-A-W-N." " Sir?" " Yeah?" "Sir, the FBI is here." " The FBI is here now?" " Yes, sir." "Right over there." "Hold this." "Want a breath mint?" "Hey, how you doing, man?" "I'm Agent Johnson." "This is Special Agent Johnson." " Oh, how you doing?" " No relation." "I'm, uh..." "I'm Dwayne Robinson, LAPD." "I'm in charge here." "Not any more." "Hi, there." "How you doing?" "Ohh..." "Please, God." "No." "You're one ofthem, aren't you?" "You're one ofthem." "No!" "Don't kill me!" "Please!" "Don't kill me, please!" "Please, please, please." "Whoa." "Relax." "I'm not gonna hurt you." "I'm not gonna hurt you!" "Oh, God." "What the fuck are you doing up here?" "What were you looking for?" "I managed to get out ofthere and" "I was just trying to get up on the roof and see if I could signal for help." "It's just over here." "Why don't you come and help?" "Hold it." "Forget the roof." "I said forget the roof." "They got people all over it." "You want to stay alive, you stay with me." "The best we can figure it, we've got maybe 30 or 35 hostages up there probably on the 30th floor and maybe seven or eight terrorists up there." "Sounds like an A-7 scenario." "Thank you." "We'll handle it from here." "When we commandeer your men, we'll try and let you know." "Aren't you forgetting something?" "Such as?" "What about John McClane?" "He's the reason we have any information." "He's also the reason you're facing seven terrorists, not twelve." "He's inside?" "Who is he?" "He might be a cop." "We're checking on that." " One ofyours?" " No, no way." "You smoke?" "Yeah." "Thanks." "You don't work for Nakatomi." "And ifyou're not one ofthem..." "I'm a cop from New York." "New York?" "Yeah." "Got invited to the Christmas party by mistake." "Who knew?" "Better than being caught with your pants down, huh?" "I'm John McClane." "You're, uh..." "Clay." "Bill Clay." "Know how to use a handgun, Bill?" "I spent a weekend at a combat ranch." "That game with the guns that shoot red paint." "Probably seems kind of stupid to you." "Nope." "Time for the real thing, Bill." "All you got to do is pull the trigger." "Come on." "Put down the gun and give me my detonators." "Well, well, well..." "Hans." "Put it down now." "That's pretty tricky with that accent." "You oughta be on fucking TV with that accent." "But what do you want with the detonators?" "I already used all the explosives." "Or did I?" "I'm going to count to three." "Yeah." "Like you did with Takagi?" "Oops." "No bullets." "What do you think..." "I'm fucking stupid, Hans?" "You were saying?" "Karl." "SchieB dem Fenster." "Shoot the glass!" "Jesus Christ!" "Smile, Karl." "We're back in business." "..is the lastresort ofdiplomacy, then couldn't wejustas well say that terrorism has an equal claim on being that, too?" "Tell me you got something." "McClane's name, badge number, employment record, vital statistics, and his family's home address right here in LA." "Whoo!" "Go to work." "Got it." "God, that man looks really pissed." "He's still alive." "What?" "Only John can drive somebody that crazy." "Hans, you better heat up that miracle because we just broke through on number six and the electromagnetic came down like a fucking anvil." "Have a look at what our friends outside are doing and I'll be right up." "Hey, John." "John McClane, you still with us?" "Yeah." "But all things being equal, I'd rather be in Philadelphia." "Chalk up two more bad guys." "The boys down here will be glad to hear that." "We gota poolgoing on you." "What kind of odds am I getting?" "You don't want to know." "Put me down for 20." "I'm good for it." "Hey, pal, you gotflatfeet?" "What the hell are you talking about, man?" "Something had to get you offthe street." "What's the matter?" "You don't thinkjockeyingpapers across a desk is a noble effortfora cop?" "No." "I had an accident." "The wayyou drive, I can see why." "What'd you do ?" "Run over your captain's foot with the car?" "I shot a kid." "He was 13 years old." "Oh, it was dark." "I couldn'tsee him." "He hada raygun, lookedreal enough." "When you're a rookie, they teach you everything about being a cop except how to live with a mistake." "Anyway, ljust couldn'tbring myself to drawmygun on anybody again." "Sorry, man." "Hey, man, how could you know?" "I feel like shit anyway." "Well, then, this won't matter." "The LAPD is not calling the shots down here any more." "The Feds?" "You got it." "Those are the city engineers." "Wait." "They're going into the street circuits." "Those guys in the suits, I don't know who they are." "That's the fbi." "They're ordering the others to cut the building's power." "Regular as clockwork." "Or a time lock." "Precisely." "The circuits that cannot be cut are cut automatically in response to a terrorist incident." "You asked for miracles, Theo." "I give you the F-B-l." "I want the building shut down." "I got a problem." "I got a switch..." "I don't care about your switch." "I want it out." "Dark!" "You can't do it from here." " Yeah, you could." " It can't be done from here." "I could just..." "I got the radio..." "You can't do it from here." "It's got to be done from downtown." "They've gotta take out a whole city grid." "We're talking 10 square blocks." "Ten blocks?" "Johnson, that's crazy." "It's Christmas Eve." "There's thousands of people." "You have to go wider." " I need authorisation." " How about the United States government?" "Lose the grid, or you lose yourjob." " Yeah, Central?" " Yeah?" "This is Walt down at Nakatomi." "Would it be possible for you to turn off grid 212?" "Are you crazy?" "!" "Maybe I should call the Mayor." "No shit it's my ass." "I got a big problem here." "Shut it down now." "Emergency lighting activated." "Al, talk to me." "What's going on here?" "Ask the fbi." "They got the universal terrorist playbook and they're running it step by step." "It's gonna go." "It's gonna go!" "Yes!" "Merry Christmas." "They must be pissing in their pants." "The Mayor is gonna have my ass." "Whoo!" "What are we gonna do now ?" "Arrest them for not paying their electric bill?" "We've shut them down." "We let them sweat for a while, then we give them helicopters." "Right up the ass." "This is Agent Johnson." "No, the other one." "I want that air support ready to lift off in five minutes." "Damn right." "Fully armed." "We're on the way." "Oh, yes!" "I wish to talk to the fbi." "This is Special Agent Johnson." "The State Departmenthas arranged for the return ofyour comrades." "Helicopters are en route as you requested." "I hearyou." "We'll be ready." "By the time he figures out what hit him, he'll be in a body bag." "When they touch down, we'll blow the roof." "They'll spend a month sifting through the rubble." "By the time they figure out what went wrong, we'll be sitting on a beach earning 20%." "Ah!" "Jeez!" "Powell?" "Yo, Powell, you got a minute?" "I'm here, John." "Listen, I'm starting to get a bad feeling up here." "I want you to do something for me." "Um... ahem..." "I want you to find my wife." "Don't ask me how." "By then you'll know how." "Uh, I want you to tell her something." "I want you to tell her that..." "Tell her it took me a while to figure out what ajerk I've been but, um... that... that when things started to pan out for her" "I should have been more supportive." "And, uh..." "Ijustshouldhave been behind hermore." "Oh, shit." "Tell her that, um that she's the best thing that ever happened to a bum like me." "She's heard me say "l love you" a thousand times." "She never heard me say I'm sorry." "I want you to tell her that, Al." "Tell her that John said that he was sorry." "OK?" "You got that, man?" "Yeah, lgotit, John." "But you can tell her that yourself." "You just watch your ass and you'll make it out." "You hear me?" "I guess that's up to the man upstairs." "John?" "John?" "What the fuck were you doing upstairs, Hans?" "John?" "No, Al, listen." "Just lay offfor a while." "I gotta go check on something." "One minute, that's all I'm asking." "One minute to speak to them." "All right." "Get back." "Get back." "All right, look." "You let me in right now, or I call the INS, comprende?" "This is the last time these kids are gonna have to speak to their parents." "All right?" "All right." "Come on." "Come on." "What were you doing, Hans?" "What were you doing?" "Jesus, Mary, mother of God." "Al, listen to me!" "It's a double-cross!" "The roof is wired to..." "John?" "John!" "John, come in!" "Did you get that?" "Something about a double-cross." "Tell me about it." "We are both professionals." "This is personal." "Aww..." "They're coming!" "Choppers are coming." "Time to gather your flock, Miss Gennero." "Your mom and dad are veryimportantpeople." "They're verybrave people." "Is there somethingyou'dlike to say to them, ifthey're watching?" "Come home." "Mrs McClane." "How nice to make your acquaintance." "On your feet, everyone!" "To the roof!" "Lock them up there and come right back." "You should have heard your brother squeal when I broke his fucking neck!" "What do you figure the breakage?" "I figure we take out the terrorists," "lose 20, 25% ofthe hostages, tops." "I can live with that." "Get this thing on the deck." "They're expecting transports, not gun ships." "Move it!" "Come on!" "Move!" "Come on!" "Come on!" "Move it!" "Go!" "Move!" "Theo." "A little bonus for us." "Please, sit down." "Sit down!" "A policeman's wife might come in handy." "McClane, I have some news for you." "McClane?" "Move!" "Come on!" "Motherfucker!" "I'll kill you!" "Armed." " The truck?" " The truck." "After all your posturing, all your little speeches, you're nothing but a common thief." "I am an exceptional thief, Mrs McClane." "And since I'm moving up to kidnapping, you should be more polite." "You motherfucker, I'm gonna kill you!" "I'm gonna fuckin' cook you, and I'm gonna fuckin' eat you!" "I don't like this, Sarge." "Yee-hah!" "Just like fucking Saigon, eh, Slick?" "I was in Junior High, dickhead." "Where's Holly?" "Where's Holly Gennero?" "Holly Gennero?" "Where's Holly?" "Where's Holly?" "Where is she?" " They took her!" " Where?" "The vault!" " Where is the vault?" " The 30th floor!" "They just took her!" "Get downstairs!" "The whole fucking roof is wired to blow!" "Get down!" "Get down!" "Get the fuck downstairs!" "They made us, Bureau." "Terrorist shooting hostages." "Break left!" "Nail that sucker!" "I'm on your side, you assholes!" "Swing around again!" "I'll bag this little bastard." "What the fuck..." "Oh, John, what the fuck are you doing?" "How the fuck did you get into this shit?" "There's something wrong!" "They're coming back down!" " Blow the roof." " But Karl's up there!" "Blow the roof!" "I promise I will never even think about going up in a tall building again." "Oh, God, please don't let me die!" "Holy Christ!" "We're gonna need some more FBI guys, I guess." "Jesus fucking Christ!" "Fuck!" "What the fuck is going on?" "What are you gonna do?" "Sit here while the building falls down?" "Shit!" "All right!" "Hey!" "Hey!" "Hang on, baby." "Hang on, honey." "Oh, God." "Hans!" "Jesus." "Hi, honey." "So that's what this is all about?" "A fucking robbery?" "Put down the gun." "Why'd you have to nuke the whole building, Hans?" "Well, when you steal $600, you can just disappear." "When you steal 600 million, they will find you unless they think you're already dead." "Put down the gun." "Nein." "This is mine." "You got me." "Still the cowboy, Mr McClane." "Americans... all alike." "This time, John Wayne does not walk off into the sunset with Grace Kelly." "That was Gary Cooper, asshole." "Enough jokes." "You'd have made a pretty good cowboy yourself, Hans." "Oh, yes." "What was it you said to me before?" "Yippee-ki-yay, motherfucker." "Holly!" "Happy trails, Hans." " Aah!" " Holly." "I hope that's not a hostage." "Gimme water hook-ups for engine companies 5, 3, 9, 6." "Over here." "It's a better angle." "Let's give them a hand." "Keep it going, now." "Keep it going." " Come on." "We're going to miss it!" " OK." "Hand me my notes!" "What was it like in there?" "How did they treat you?" "Al, this is my wife Holly." "Holly Gennero." "Holly McClane." "Hello, Holly." "You got yourself a good man." "You take good care of him." "McClane!" "McClane, I want a debriefing!" "You got some things to answer for, mister." "Ellis' murder, for one thing." "Property damage, interfering with police business." "Two ofyou go inside and see ifthere's anybody else!" "No." "This one's with me." "Mr McClane, Mr McClane!" "Now that it's all over, after this incredible ordeal, what are your feelings?" "Well, well, well." " Merry Christmas, Argyle." " Merry Christmas." "Did you get that?" "Let me through." "If this is their idea of Christmas, I gotta be here for New Year's."

ROUGEMONT, N.C. (WTVD) -- A Triangle sanctuary says they have had to turn down requests for help due to a spike in the number of pot belly pig surrenders and strays. Blind Spot Animal Sanctuary in Rougemont receives more than a dozen calls weekly from both shelters and citizens looking for assistance."There is this misconception of 'teacup pigs,' 'micro-pigs.' There's no such things, they don't exist. It's just a marketing term, a misleading marketing term. So we're seeing nearly every year more and more pleas for these animals," explained Alesja Daehnrich, a co-founder of the sanctuary.Last week, they took in five pigs from shelters, including three from the Orange County Animal Shelter.Orange County Animal Shelter Executive Director Bob Marotto said they have received eight pigs so far this year; from 2014-2016, the average was one or two annually."Whether you're getting good information or bad information from a breeder, you really need to do your homework. Whether the pig can live with you, that you can provide for it, that you can meet its needs," said Marotto."A lot of the people who get a pig, they are rarely educated on their care and what to expect," said Daehnrich.While the shelter can provide short-term housing for a pig, it cannot give long-term care, making sanctuaries so important.Advocates take particular issue with the term 'teacup,' when many of these pigs can quickly grow to more than 100-pounds."Everything small, everything cute sells ten times better than when (sellers) would say it's going to be a 150-pound pig," said Alex Daehnrich, Alesja's husband and fellow co-founder.Pigs also begin producing at a very young age, creating potential additional difficulties for owners attempting to domesticate them.Blind Spot Animal Sanctuary is working with other organizations to find homes for pigs they cannot accept. They do adopt out their pigs in an effort to create more room to take others in, but urge people to do their research before adopting.Animal advocacy group PETA has written on the issue of 'teacup pigs,' urging people to "never buy one." To learn more about their position, click here

The proposed study has three central objectives: 1) an evaluation of the impact of the new Massachusetts mental health law on involuntary civil commitment of the mentally ill; 2) the preliminary development and evaluation of a "dangerous to others" assessment instrument; and 3) a survey of legal and psychological concepts of dangerousness and their relationship to social policy objectives. Subjects will be in-patients at the Massachusetts Mental Health Center, the Boston State Hospital, the Gardner State Hospital and Bridgewater State Hospital. Socio-demographic, clinical and behavioral variables will be studied with relation to their influence on decision- making for or against the release of patients. Patients will be interviewed by project staff and will be followed up one year later by direct interview and telephone. Court proceedings for subjects for whom involuntary civil commitment is sought will be observed and data collected relevant to the adequacy of the litigation, the adequacy of the protection of the patient's civil rights and the quality of the operation of the new Massachusetts mental health statute.

DESCRIPTION (APPLICATION ABSTRACT): Recent efforts to reduce costs and streamline the delivery of healthcare have led to significant changes in the acute care workplace. In addition, the increased use of technology and an aging population are likely to lead to an increased volume of intensive care unit (ICU) patients in the future. The main objective of this study is to investigate the effect of varied working conditions (workforce staffing and organizational climate) in ICUs on elderly patient safety outcomes (nosocomial infections [NIs], length of stay, mortality, and disposition at discharge), and healthcare worker safety (musculoskeletal injuries, blood/body fluid exposure, sick days, and disability days). To do this, we will obtain and analyze data from a variety of sources. We propose to 1) obtain Medicare data for patients admitted to ICUs participating in the National Nosocomial Infection Surveillance (NNIS) system during 3 different years (1996, 1999, and 2002); 2) link the Medicare data to NNIS data and other existing datasets; 3) survey the same hospitals regarding ICU specific workforce staffing and healthcare worker safety; and 4) survey nursing personnel currently employed in these ICUs regarding organizational climate. We will employ econometric multivariate regression data analytic methods in which we will control for patient severity of illness, the nurse labor market and healthcare setting characteristics. A unique aspect of our proposed study is the use of NNIS data (the gold standard) to measure an important nurse-sensitive patient safety outcome across hospital-linked claims data and working conditions. By examining these data, we will be able to assess the impact of the changes in ICU working conditions on patient safety outcomes, and healthcare worker safety. Because ICU care and the nursing workforce are expected to continue to experience rapid change, this information is of major importance to those who manage or oversee health care organizations and set policies affecting the working conditions. In addition, obtaining NNIS and Medicare data creates an opportunity to explore the sensitivity and specificity of identifying NI through claims data.

The photochemical conversion of reactants having a reactant core portion of 5,7-androstadiene-1.alpha.,3.beta.-diol, into a product having an altered product core portion, 9,10-seco-5(10),6,8-androstatriene-1.alpha.,3.beta.-diol, is known. Furthermore, it is known that this reaction proceeds most efficiently when the irradiating light is restricted to being in the range from about 275 or 280 nm (nanometers) to about 310 nm. Such is discussed, for example, by Sato, et al, J. Nutr. Sci. Vitaminol. 26, 545-556, 1980; in Sato, et al Chem. Pharm. Bull. 26 (10) 2933-2940 (1978); and Barton, et al, J. Am. Chem. Soc. 95, 2748-2749 (1973). Unfortunately, relatively low yields, of the order of 15 to 40%, of 1.alpha.-hydroxyprevitamin D.sub.3 are producible by the prior art methods. And, such methods have normally produced relatively great amounts of undesirable byproducts through decomposition of materials in the reaction mixture. A method of producing 1.alpha.-hydroxyprevitamin D.sub.3 in better yields and with less destruction of valuable starting 1.alpha.-hydroxyprovitamin D.sub.3, and of producing related compounds, would be highly desirable. The present invention is directed to overcoming one or more of the problems as set forth above.

Continuous measurement of enzymatic kinetics in droplet flow for point-of-care monitoring. Droplet microfluidics is ideally suited to continuous biochemical analysis, requiring low sample volumes and offering high temporal resolution. Many biochemical assays are based on enzymatic reactions, the kinetics of which can be obtained by probing droplets at multiple points over time. Here we present a miniaturised multi-detector flow cell to analyse enzyme kinetics in droplets, with an example application of continuous glucose measurement. Reaction rates and Michaelis-Menten kinetics can be quantified for each individual droplet and unknown glucose concentrations can be accurately determined (errors <5%). Droplets can be probed continuously giving short sample-to-result time (∼30 s) measurement. In contrast to previous reports of multipoint droplet measurement (all of which used bulky microscope-based setups) the flow cell presented here has a small footprint and uses low-powered, low-cost components, making it ideally suited for use in field-deployable devices.

Relationship between adenoid size and severity of obstructive sleep apnea in preschool children. To investigate the contributions of adenoid and tonsil sizes to obstructive sleep apnea syndrome (OSAS) in normal-weight children in two age categories: preschool and schoolchildren. Fifty-eight normal-weight (body mass index z-score<2) symptomatic children with OSAS (apnea-hypopnea index ≥ 2) were evaluated. The patients were divided into two age categories: preschool (age<6; n=33) and schoolchildren (age ≥ 6; n=25). Polysomnographic findings and adenoid and tonsil sizes were compared. The relative contributions of body mass index and adenoid and tonsil sizes were also investigated with a regression analysis. Adenoid grade and apnea index correlated significantly in preschool children (r=0.45, p<0.01). On regression analysis, adenoid grade was a significant predictor of the apnea index in preschool children. The influence of adenoid hypertrophy decreased from preschool to schoolchildren. Tonsil size had little influence on the apnea index in either group. Adenoid hypertrophy was a major contributor to OSAS in normal-weight preschool children. The upper airway morphology of younger children with OSAS differed from that of older children with OSAS.

The invention relates to multi-computer systems. More particularly, the invention relates to methods and equipment for recovery processing in the event of a computer failure. Multi-computer systems employ a plurality of computers. A single computer runs a single kernel, whereas a multi-computer runs multiple kernels. As so defined, a single computer may include one or many processors. The constituent computers in a multi-computer may be in distinct physical units (e.g., chassis or circuit boards) or individual processors together in the same physical unit or some combination of both. One example of a multi-computer system is one in which redundant computers are present. The use of redundant devices in computer systems is advantageous in critical applications because the redundant devices increase system availability, survivability, and robustness. In a multi-computer systems one or more computers may be redundant computers able to take over processing workload abandoned by a primary computer that has failed. A redundant computer may be connected to peripheral storage devices (e.g., disk drives) through separate hardware paths than used to connect a primary computer to the peripheral storage devices. A redundant computer may be inactive unless and until the primary computer fails. Alternatively, multiple active computers in the same scalable computer system may be redundant with respect to each other in the sense that one of the computers can takeover execution of an application program (also called simply xe2x80x9capplicationxe2x80x9d) originally executed by computer that subsequently fails. A computer stores data to peripheral storage by issuing one or more xe2x80x9cwrite requestsxe2x80x9d (sometimes simply referred to as a xe2x80x9cwritesxe2x80x9d) to a peripheral storage device. Typically write operations are asynchronous, i.e., the computer issues a write request and is notified of its completion some time later. A busy computer may have multiple writes outstanding at the same time. Once issued, a write request may be delayed, perhaps indefinitely. Sources of indefinite delay include failure of communications channels between the computer and the storage device, and failures within the storage device itself. Normally, a computer xe2x80x9ctimes outxe2x80x9d such writes and reissues them if necessary. Failing receipt of a write completion acknowledgment, the requesting computer typically records the failed state of the peripheral storage device. When an operating computer fails, it may have pending writes that have been issued but neither completed nor timed-out. When a pending write requests from a failed computer is effectuated (i.e., actually written on a storage device), the phenomena is referred to herein as a xe2x80x9cghost write.xe2x80x9d That is, a ghost write is effectuated on behalf of a dead computer. A ghost write may seriously interfere with recovery processing whereby a redundant computer takes over for the failed computer. When an operating computer fails, a recovery routine is executed to transfer application programs (also called, more simply, xe2x80x9capplicationsxe2x80x9d) to a redundant computer. An application is typically terminated and then restarted on the redundant computer. Recovery of an application following unexpected termination usually involves reading peripheral storage utilized by the application and analyzing the data to determine the state of the application program at the time of the failure. If necessary, the state of the peripheral storage devices is altered so as to eliminate partially completed writes. The objective of the alteration is to back up in time to a known good, consistent state, because partially completed writes place the storage devices contents into an inconsistent state. A ghost writes can interfere with the recovery processing by either (1) corrupting the data read from the peripheral storage or (2) overwriting corrections made for the purpose of restoring consistency. In one respect, the invention is a method for preventing ghost writes in a multi-computer system. A first computer in the multi-computer system issues one or more write requests to a storage device, each write request normally being effectuated after being pending for a time. The method generally comprises the steps of detecting a condition indicative of a failure associated with the first computer and preventing the effectuation of write requests issued by the first computer to the storage device and pending at the time of the detected condition. In one embodiment, the condition indicative of a failure associated with the first computer comprises at least one of the group consisting of a reduction in the number of known operating computers in the multi-computer system, and a state change of a volume group associated with the computer on the storage device from inaccessible to accessible and a reduction in the number of known operating computers in the multi-computer system. In another embodiment, the failure is a communication failure associated with one or more write requests to a storage device connected along a plurality of redundant communications channels. In yet another embodiment, the preventing step comprises at least one action from the group consisting of issuing a fibre channel target reset on a fiber channel connected to the storage device, issuing a fibre channel remote logout on a fiber channel connected to the storage device, issuing a fibre channel remote logout and a requiring logout from multiple fibre channels on a fiber channel connected to the storage device, and issuing a bus device reset on a bus connected to the storage device. In other respects, the invention is computer software embedded on a computer readable medium. The computer software comprises instructions for implementing the methods just summarized. In yet another respect, the invention is an apparatus. The apparatus comprises a first computer, a storage device, at least one adapter connected between the first computer and the storage device, and an application executing on the first computer. The adapter comprises a protocol capable of selectively eliminating write requests issued to the storage device before effectuation of the selected write requests. The application comprises an activation procedure that executes upon startup of the application. The activation procedure is connected to the adapter and commands the adapter to eliminate uneffectuated write requests. In one embodiment, the activation procedure executes following at least one event from the group consisting of a reduction in the number of known operating computers in the multi-computer system, and a state change of a volume group associated with the computer on the storage device from inaccessible to accessible and a reduction in the number of known operating computers in the multi-computer system. In another embodiment, the activation procedure performs at least one action from the group consisting of issuing a fibre channel target reset on a fiber channel connected to the storage device, issuing a fibre channel remote logout on a fiber channel connected to the storage device, issuing a fibre channel remote logout and a requiring logout from multiple fibre channels on a fiber channel connected to the storage device, and issuing a bus device reset on a bus connected to the storage device. In comparison to the prior art, certain embodiments of the present invention are capable of achieving certain advantages, including the ability to recover more satisfactorily from a computer failure when there is the potential for ghost writes. Those skilled in the art will appreciate these and other advantages and benefits of various embodiments of the invention upon reading the following detailed description of a preferred embodiment with reference to the drawings.

tag:blogger.com,1999:blog-7941261488380355005.post2962002046537190025..comments2015-03-30T10:25:51.448-07:00Comments on Raising Matt Cain: Pat the BatM.C. O'Connorhttp://www.blogger.com/profile/12258035192484655635noreply@blogger.comBlogger5125tag:blogger.com,1999:blog-7941261488380355005.post-64922410283964155252010-08-01T17:52:23.821-07:002010-08-01T17:52:23.821-07:00Matt MUST beat these guys! How can he ever really...Matt MUST beat these guys! How can he ever really be a great Giant if he never beats them!! Come on 18 starts is not exactly a small sample size. I know we can all make excuses about run support and &quot;luck&quot; but I don&#39;t want to hear it. Even if he has to throw a shutout AND hit a homer, Cain MUST beat these assholes!JC Parsonshttp://www.blogger.com/profile/00666659454815710731noreply@blogger.comtag:blogger.com,1999:blog-7941261488380355005.post-8072666336903882882010-08-01T15:43:36.780-07:002010-08-01T15:43:36.780-07:00Yeah, Freddy&#39;s been soft swingin&#39; and miss...Yeah, Freddy&#39;s been soft swingin&#39; and missin&#39; for a while now. <br /><br />I guess that the Padres felt that they really needed a hitter so they got a little creative. Another hitter would have been swell, however, I&#39;m guessing most of the other teams see us as the pitchers store. I wouldn&#39;t want to lose Dirty or Madbum for a hitter. <br /><br />If our starters keep pitching good, if our bullpen can be a little more stable, and our offense can provide enough runs, I&#39;ll feel fine. <br /><br />The Yankees had a pretty bad bench so I guess adding Kearns and Berkman fixed that up for them. Kerry Wood they figured could do as good a job as Park if not better.<br /><br />I must say though, if our pitching holds up and our guys keep playing good, we won&#39;t need the additional hitters. Pitching wins it in the long run, especially strikeout pitchers. Timmeh and Dirty are K machines, as well as most of the bullpen. Walks I feel are over exaggerated. It&#39;s only worth one bag. The Giants give up the 2nd fewest hits in baseball. I believe pitchers have a bigger role in hits than people think. Hits win games, walks not as much. <br /><br />Last year, the Phillies could have won. Had they played Lee a game earlier, they would have had more momentum. They should have had more faith in J.A. Happ. I feel that he would have done better than Blanton. Poor faith and management in the pitching department led to the Phillies losing pretty easily without Cliff Lee. Good pitching silences good hitting and if we can bring some of our good pitching into the postseason, we have a real shot.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7941261488380355005.post-90981220140770066862010-08-01T14:39:08.302-07:002010-08-01T14:39:08.302-07:00I&#39;m a little surprised the Padres were able to...I&#39;m a little surprised the Padres were able to get a good player so easily, and it makes me wonder why the Giants could not. Ludwick would have been a perfect fit, and could have been added to the team for less than the two relievers cost us. I know we need the bullpen help, but another hitter would have been nice. We just have to hope that The Big Three--Posey, Huff, Torres--don&#39;t slow down at all and that Sandoval can find his 2009 form.<br /><br />I realize the Giants are a good team and playing well, but take a look at the Yankees. They are the team with the BEST RECORD IN BASEBALL and they SCORE THE MOST RUNS and they added TWO hitters (Berkman and Kearns)!! How is it that they feel they need MORE offense and the Giants feel that they DON&#39;T need more offense? Explain, please. <br /><br />Also, I&#39;ve had enough of FSanchez batting 2nd. That&#39;s ridiculous--there&#39;s nothing about his bat that justifies putting him up so high in the lineup. We&#39;d be better off with Sandoval, Burrell, or Uribe in the top four.M.C. O'Connorhttp://www.blogger.com/profile/12258035192484655635noreply@blogger.comtag:blogger.com,1999:blog-7941261488380355005.post-32710276108860255232010-08-01T14:26:09.719-07:002010-08-01T14:26:09.719-07:00It&#39;s time to shut the door on these assholes. ...It&#39;s time to shut the door on these assholes. I still can&#39;t believe half of the trades that they made. The scary thing is, I could see Sabean making those moves if the Dodgers didn&#39;t beat him to the punch. Ted Lilly is having a down year according to FIP (and even his record could tell you that), Scotty&#39;s been a bit lucky but isn&#39;t the best fielder, Theriot has a cool name but he will probably make them worse. Octavio will probably be about average for them. I know I said this yesterday but it just makes me feel good every time I think about it. <br /><br />Go Giants!Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7941261488380355005.post-53964325748939854882010-08-01T13:20:09.473-07:002010-08-01T13:20:09.473-07:00I agree it&#39;s time for Matty to beat these guys...I agree it&#39;s time for Matty to beat these guys.Greg Wurzhttp://www.blogger.com/profile/05151808554225281357noreply@blogger.com

The associations between current recommendation for physical activity and cardiovascular risks associated with obesity. To examine associations between current recommended physical activity levels and body mass index (BMI) with some cardiovascular disease (CVD) risk factors (total cholesterol, high-density lipoprotein cholesterol (HDL-C), non-HDL-cholesterol (non-HDL-C), C-reactive protein (CRP), fibrinogen, and blood pressure), general health score (GHQ12) and predicted coronary heart disease (CHD) risk. Further analysis of the cross-sectional Scottish Health Survey 1998 data. Five thousand four hundred and sixty adults 16-74 years of age. After controlling for some confounding factors, obesity was significantly associated with higher odds ratio (OR) for elevated cholesterol, CRP, systolic blood pressure, non-HDL-C and lower HDL-C (P<0.001), and with greater predicted CHD risk compared to BMI <25 kg/m(2). Regular self-reported physical activity was associated with smaller OR of lower HDL-C and higher CRP, and average predicted 10-year CHD risk in obese subjects, but did not eliminate the higher risk of the measured CVD risk factors in this group. The OR of these two risk factors were still high 4.39 and 2.67, respectively, when compared with those who were inactive with BMI <25 kg/m(2) (P<0.001). Those who reported being physically active had better GHQ scores in all BMI categories (P<0.001). Reporting achievement of recommended physical activity levels may reduce some CVD risk factors, predicted CHD risk and improve psychosocial health, but may not eliminate the extra risk imposed by overweight/obesity. Therefore, increasing physical activity and reducing body weight should be considered to tackle CVD risk factors.

Many conventional regulators include a valve body and a control assembly for regulating fluid flow through the valve body. The control assembly generally comprises a control element such as a valve plug, for example, coupled to a diaphragm or other pressure sensing device for automatically moving the control element in response to pressure changes at the outlet of the valve body. Additionally, some conventional regulators include a spring that biases the control element into a predetermined position in the valve body, e.g., an open position or a closed position. So configured, during operation, the spring naturally biases the control element into its predetermined position and changes in the outlet pressure change the position of the control element to enable or disable fluid flow through the valve body, as desired. Fluid flowing through the valve body can generate vibrations in the system. High and low frequency resonance caused by these vibrations can hamper the operational integrity of the regulators. One solution for reducing resonance is to include a spring clip surrounding a portion of the load spring to dampen vibrations. One conventional design of a spring clip 1 includes a generally U-shaped member such as that depicted in FIGS. 1 and 2. The spring clip 1 depicted in FIGS. 1 and 2 includes a body plate 2 and a pair of opposing arm plates 3 extending outwardly therefrom. When assembled into the regulator, the spring clip 1 is positioned into a cylindrical cup shaped member 4, as depicted in FIG. 2, and then a bottom portion of a spring 5 is disposed positioned between the opposing arm plates 3 and body plate 2. This assembly process can be tedious and time-consuming as the spring clip must be manually manipulated to spread the arm plates 3 apart.

Olfactory performance acts as a cognitive reserve in non-demented patients with Parkinson's disease. To explore whether olfactory performance acts as a cognitive reserve in non-demented patients with Parkinson's disease (PD). Patients with non-demented PD (n = 119) underwent T1-weighted MRI and olfactory identification tests. According to their olfactory performance, PD patients were subdivided into three groups of high score (PD-H, n = 38), middle score (PD-M, n = 48), and low score (PD-L, n = 33). We investigated the pattern of gray matter (GM) density according to olfactory performance using voxel-based morphometry (VBM) and analyzed the correlation between GM density and olfactory performance. No significant differences in demographic characteristics were observed among the groups. A neuropsychological test showed that cognitive deficits in verbal memory function were more severe in the PD-L group than in the PD-H group. However, a VBM analysis revealed that patients in the PD-H group possessed significantly decreased GM density in the bilateral temporal areas, orbitofrontal areas, mesiofrontal areas extending into the cingulate gyrus, and prefrontal areas, compared with patients in the PD-L group. No areas exhibiting a significant difference in GM density were observed between the PD-H and PD-M groups. Olfactory performance in patients with PD was negatively correlated with both the brain GM volume and intracerebral volume; in particular, GM density in the caudate nucleus and putamen exhibited a negative correlation with olfactory performance. Our data show that a high olfactory performance may compensate GM volume loss in order to minimize the exhibition of cognitive impairment and thus may act as a cognitive reserve in non-demented patients with PD.

Does stage at diagnosis explain the difference in survival after breast cancer in Denmark and Sweden? Breast cancer survival differs 9 percentage points between the neighbouring countries of Denmark and Sweden. The authors' aim was to analyse whether this was caused by early detection in Sweden. The extent of disease and outcome was compared in two population-based breast cancer cohorts in 1983-1989. Breast cancer management was decentralized in Denmark without mammography screening whereas treatment in Sweden was centralized and the population partly screened. Ten- and 15-year relative survival was 15% and 6% higher in Sweden (p<0.001) with corresponding differences in crude and disease-specific survival. Stage distribution was significantly more favourable in the Swedish cohort. In multivariate analysis age, tumour size, extent of axillary surgery, and spread affected survival; however, the impact of region persisted (p<0.001). Reanalysis without screening-detected patients only slightly affected the impact of region. It was concluded that early detection had significant impact on survival but other regional differences might be of importance.

About 50% of the people in the U.S. require prescription eyewear. The vast majority of these people wear conventional eyeglasses and even the people who wear contact lenses will wear eyeglasses from time to time. For these people, the solutions for addressing their sunglasses needs are not satisfactory. One solution is to wear photo-gray lenses in their glasses. This solution is reasonably good at providing an "all-in-one" solution. However, these lenses usually take a while to change plus they are not as stylish as most sunglasses, and can be very heavy as the lenses must be made of glass. Another possible solution is to maintain two pairs of glasses, one with regular lenses and one with tinted lenses. This solution is attractive and feasible if the individual can afford both pairs and wear the sunglasses for extended periods, thus avoiding frequent switching of glasses. Yet another solution is to wear a pair of tinted goggles over the prescription glasses. These are functional, but awkward and not very stylish. The final alternative is the conventional clip-on which is generally flimsy and not very stylish, standing out obviously as clip-ons. The clip-ons are not very versatile with each type of clip-on fitting only a limited set of eyeglass frames. Even if a person is able to find a clip-on that fits, the attachment is likely to be unreliable and lost or damaged in a strenuous activity such as snow skiing. As a consequence, it is the object of this invention to provide to those who wear conventional eyeglasses an improved removable sunglasses design that is 1) easily attached and detached to and from a large variety of eyeglass frames; 2) securely mounted with respect to the frames; 3) comparable to conventional sunglasses in fashion and attractiveness; 4) simple and economical to manufacture; and 5) designed for reliability with a minimum number of parts with no conventional clips, springs, screws, or moving parts.

"Hey." "I know it's been a while." "I'm gonna be honest, i forgot about you." "After the farm, we were always moving." "But something happened." "Something good." "Finally." "We found a prison." "Daddy thinks that we can make it into a home." "He says we can grow crops in the field, find pigs and chickens, stop running, stop scavenging." "Lori's baby is just about due." "She'll need a safe place when it comes." "The rest of us, we just need a safe place to be." "I woke up in my own bed yesterday." "My own bed in my own room." "But I've been keeping my backpack." "Keeping my gun close." "I've been afraid to get my hopes up thinking we can actually stay here." "The thing is, I've been starting to get afraid that it's easier just to be afraid." "But this morning daddy said something." "If you don't have hope, what's the point of living?" "So I unpacked my bag and I found you." "So I'm gonna start writing in you again." "And I'm gonna write this down now because you should write down wishes to make them come true." "We can live here." "We can live here for the rest of our lives." "We should do something." "We should do something." "We aren't the only survivors." "We can't be." "Rick, michonne, they could be out here." "Maggie and Glenn could have made it out of a block." "They could've." "You're a tracker." "You can track." "Come on." "The sun will be up soon." "If we head out now, we can" "fine." "If you won't track, I will." "Could be Luke's." "Or Molly's." "Whoever they are, it means they're alive." "No." "This means they were alive four or five hours ago." "They're alive." "They picked up the pace right here." "Got out in a hurry." "Things went bad." "Wouldn't kill you to have a little faith." "Yeah, faith." "Faith ain't done shit for us." "Sure as hell didn't do nothing for your father." "They'll be hungry when we find them." "What?" "That ain't Walker blood." "The trail keeps going." "They fought them off." "No." "Got Walker tracks all up and down here." "At least a dozen of them." "Come on." "We're not gonna die." "None of us." "I believe now." "I believe for daddy." "If this doesn't work, i don't know how I could keep going." "Don't cry." "I want Carol." "Well, she's not here." "Here, put this on your belt." "It's gonna get dark soon." "Where are we going?" "Farther." "Come on." "Is everybody dead?" "They're gonna hear her." "We shouldn't be out here." "We'll find a safe place soon." "We will." "Here." "Walkers!" "Here, come on." "Let's go." "It's okay." "I'll find you something to eat." "All right, go." "Look, grapes." "It's okay." " Can we eat them?" " Yeah, they're good." "Here, Lizzie, have some." "Shh." "Come on, baby girl." "Shh." "Lizzie, hand me a diaper." "" " It's okay." "All right." "Bear with me, Judith." "Okay, that's it." "Okay." "They're gonna hear her." "You're all right." "Come on." "It's all right." "I know." "I know." "All right, what do you want?" "What do you want, hmm?" "Shh." "Shh." "Okay, come on." "Shh." " They're coming!" " Ah!" "I heard it, mica!" "Don't yell at her." "She doesn't understand walkers." "You're the one who doesn't understand them." "Come on." "Watch the baby." "Mica!" "Mica!" "Mica!" " Mica." " She's gone." "You yelled at her and now she's gone." "Mica." "Mica." "Are you okay?" "I got scared." "That's okay." "We all get scared." "You did the right thing running." " What?" " She did." "You hear or see a Walker, you run." "But when you're in a group, you got to try to stay close to them, okay?" "You're bleeding." "Did I hurt your arm bad?" "It was a lot worse at the prison." "No big." "I'm sorry." "I know I'm not like Lizzie." "Don't be sorry." "You each do things your own way." " But you both get it done." " Like you and Sasha?" "You're not like Sasha." "Why not?" "Because you're still here." "Sasha isn't." " Here." " What are you doing?" "Come on." "I'm making sure you can see in both directions." "You stay like this and keep watch." "You're leaving us?" "They may be from the prison." " I need to help them." " We need you." "Mica, tuck your shirt behind your knife so it's easier to grab." " We'll be okay." " Okay." "What do you do when you see a Walker?" " Run." " Run." "Together, towards me." "Only fire if you have to." "You stay right here until I get back, okay?" "Please, please don't go." "Mica, look at me." "You can handle this." "You're tough." " Chris, head for the woods." " I can't." "Come on, Judith." "Be quiet." "She's not stopping." "Please, Lizzie, do something." "They're gonna hear us." "Shh." "Lizzie." " Ah!" "Dad!" " Christopher!" " Dad!" " Christopher!" "Lizzie, we have to run." "Lizzie?" "Lizzie." "Watch out!" "Tyreese." "How-- how..." "How'd you find us?" "Where were you?" "How'd you-- stay here, girls." "Stay on the tracks." "That was my mistake." "But the woods have more cover." "No, you don't understand." "There's a place up the tracks." "It's safe." "You can take the children there." "Trust me." "Please." "Follow the tracks." "Tyreese." "I didn't run." "I didn't leave Lizzie." "See that?" "Tough little lady." "Hey, there's some water in there." " And some food." " Yeah." "Here you go." "Here you go." "Here you go." "I didn't see you get out." "I thought you" "I wasn't there." "I hadn't gotten back yet." "Rick and I found a car." "He took what we had back to the prison while I..." "Kept looking." "Did you see it?" "I saw the end." "And then..." "I saw you running into the woods." "You were far away." "I lost you, but..." "You found us." "I knew you would." "Hey, maybe we can circle back and find your car." "The walkers and the fire-- you can't go back to a graveyard." "Look." ""Sanctuary for all." "Community for all." "Those who arrive survive."" "Sorry." "You can smile." "You're alive." "I get it." "That's not it." "Okay." "Tyreese could have made it, Sasha." "We don't know if anybody got out." "No." "We do." "How's he doing?" "Bleeding stopped." "He'll be all right." "Got the water to our backs." "Decent vantage points from the bank." "I'm thinking we camp here for the night." "That's good." "You should both be safe here." "The bus got out." "Glenn got out." " I'm gonna find him." " Maggie." "With any luck, the bus is gone." "It was heading east down the main road." "If I follow in that direction," " I might be able to pick up its tracks." " Alone?" "With just that?" "I'm out of ammo, so, yeah." "I couldn't find Beth." "I know Glenn got out and I know which way he went." "I'm gonna go get him and I'm gonna come back for you." " We both are." " Maggie." " I'm going." " We cannot split up." "Not now." "I'm going." "You said it." "We can't split up." "You could have helped me stop her." "If you're trying to make me feel sorry for you, it's not working." "Damn, it means I let myself get shot up for nothing." "The odds of us finding him..." "We should be out looking for food, shelter." "Yeah, why is that?" "So we can live." " Then what?" " What?" "Maybe we didn't survive just to keep surviving." "Shit happens." "Not everything has to mean something." "No, it doesn't have to, but it can." "If you make it that way, and that's what it seems like we're doing." "And I'm down with that." "Maggie." "Maggie!" "You should go." " Maggie, stop." " Maggie." "Maggie." "I have to know if he's in there." "Fine, but we do it together." "Smart." "We'll let them out one at a time." "Two of us should be at the door..." "In case they stack up against it." "I have to be here." "I need to see their faces." "I can't hold it." "I'm sorry." "But they got away." "They were good people." "All of them." "You should let me." "Maggie?" "Maggie!" "It's full." "Did you even fire a shot?" "All right." "Let's go." "Let's go." "Are you just gonna stay here, huh?" " You're just gonna die?" " I was part of this." "I know." "So what are you doing?" "I need your help." "We're gonna run out of bullets." "Take this and take this." "Back up." "All right." "I need you to stay ahead of me, okay?" "All right." "I'll cover you, but I can't do it alone." "You ready?" "Let's go." "Go." "Go, go, go, go, go." "" " Shoot!" "Shoot!" "Come on!" "Did you see if any of my people got out?" "All I saw was my sister in that field." "She wasn't supposed to be there." "She had a gun, but they just swarmed her." "She wasn't supposed to be there." "I did it for him." "I trusted him." "And then he just killed that old man." "Hershel?" "Was his name hershel?" "I'm sorry." "I'm so sorry." "Brian, that man, told us you were bad people." "I know it's not true." "I can see it's not, so what we did, what I did..." "I mean, I'm a piece of shit." "Why would you want my help?" "I don't want it, I need it." "I have to find Maggie." "Who's Maggie?" "She's my wife." "You guys got separated?" "I was on the bus and then I got off to help and she didn't see me." "How do you know if she made it?" "I don't know." "But hershel," "Maggie's father, was a great man." "And he told me all I had to do was believe, and that's what I'm gonna do." "Neither one of us should be alive right now." "She got out, so you're gonna help me find her." "Things aren't over." "They're not over." "I want to believe that." "I want to." "You have to." "Glenn." "Glenn." "Hey, Glenn." "Hope you enjoyed the show, assholes." "You got a damn mouth on you, you know that?" "What else you got?"

Leguminous plants fix nitrogen from the air and convert it to organic nitrogenous compounds used by the plant for protein synthesis. Nitrogen fixation in leguminous plants is possible because of the symbiotic relationship with bacteria of the genus Rhizobium and Bradyrhizobium, which forms nodules on the roots of legumes. Different species of rhizobia cause nodulation in specific legume genera. Maximum symbiotic nitrogen fixation occurs when plant and bacteria are properly matched, and when nodule formation is maximized. Bradyrhizobium japonicum is associated with (nodulates) soybeans, Rhizobium leguminosarum biovar trifolii with clovers, R. meliloti with alfalfa and sweetclovers, R. leguminosarum biovar viceae with peas and vetches, and R. leguminosarum biovar phaseoli with garden variety beans. It is common practice to inoculate leguminous plants with rhizobia to aid nodule formation. Inoculation can be accomplished by pre-inoculating seeds, or either inoculating seeds, or placing inoculant in-furrow at planting time. Previous methods of producing an inoculant have included mixing an active, living rhizobial culture with a carrier such as humus or peat. The moist carrier maintains the bacteria in a living state. An early method of preparing inoculants was by converting the bacteria to a dormant state. U.S. Pat. No. 3,168,796 to Scott, et al describes a method of preparing an inoculant including a step of freeze-drying. This process must be done rapidly to prevent cell rupture. The dried, ground bacteria are mixed with a powdered carrier such as kaolin or montmorillonite. Freeze-drying gives a high initial recovery of bacteria, but the inoculant does not remain stable for long storage periods. Another method of preparing a dry, dormant inoculant is cited in PCT Published Application No. 92/08355, published May 29, 1992. The described process produces a dry, dormant bacterial composition wherein the water content is less than 5% by weight and at least 10.sup.9 viable bacteria per gram of the composition. The carrier is a clay mixture of montmorillonite and kaolinite which has an essentially neutral pH. Such a dry, dormant bacterial composition is available commercially under the trademark Nitragin Gold. Biocidal compositions containing bacteria or fungi which combat insects, fungi or the like may also be prepared using the slow drying process described in the foregoing European patent publication. Interest in dry, dormant bacterial products has increased due to recent interest in biological pesticides as an ecological alternative to conventional pesticides. Seed coating is a popular method for applying bacterial inoculants and other beneficial bacteria such as biopesticides to the target plants, particularly for alfalfa seeds. Several methods may be used to make coated alfalfa seeds, including dusting, pelleting, and film coating. Dusting of alfalfa seeds with a dry, dormant inoculant containing R. meliloti gives rise to a product which has an excellent shelf life, but the dust is not completely adhered to the seed, resulting in release of loose dust to the surrounding atmosphere whenever the coated seeds are handled in the open. Film coated seeds have the advantage of not releasing dust. However, known film coating processes incorporate water in the process. Bacteria from a moist product, or which are rehydrated during the coating process, have poor viability upon subsequent drying. A need persists for a method of preparing a coated seed wherein the bacteria in the coating have been pre-conditioned for survival after temporary rehydration. The adverse effects of temporary rehydration on previously dried, dormant bacteria are well known.

Color cosmetics, which are used to beautifully adorn the skin of a user by making the appearance beautiful, are classified into a base makeup used for making a skin color uniform and covering a defect and a point makeup used for partially enhancing a three-dimensional effect of a lip, eyes, or nails. The base makeup includes a makeup base, a foundation and a powder, and the point makeup includes a lipstick, an eye liner, and mascara. The foundation is classified into solid-type foundation, liquid-type foundation and gel-type foundation according to a type of cosmetic contents. In case of the solid-type foundation, although the solid-type foundation has a good cover effect, the makeup is united when the makeup is refreshed. In case of the liquid-type foundation, although the liquid-type foundation gives a good close contact feel, the persistency is weak. Thus, in recent years, the number of customers favoring the gel-type foundation having a considerable persistency and a good close contact feel has been increased. Therefore, there is need to develop a container for gel-type foundation. Generally, the gel-type foundation, which is filled into a glass container or a tub-type container, is used in such a manner that a user takes some foundation on his hands for use or squeezes foundation from the container and then, coats the foundation on his skin by using a puff or his hands. However, according to the related art, since a user gets cosmetics on his hands every time that it is used, it is inconvenient to wash hands every time after use. In addition, as the hands coated with cosmetics are washed, the cosmetics are wasted. To solve the above problems, as shown in FIG. 1, a compact container having an impregnation member 1 which is impregnated with cosmetics and embedded in an inner container is disclosed in Korean Registered Patent No. 10-1257628 issued to the applicant of the present application. According to the related art, a user uses the cosmetics impregnated to the mixing member by getting a puff the cosmetics to coat the cosmetics on his skin, so that the user can wear makeup without coating user's hands with the cosmetics. However, since cosmetics impregnated to the impregnation member 1 contain a large quantity of volatile materials, when the sealing of the inner container containing the cosmetics is deteriorated, the volatile materials are volatilized into the atmosphere, so that the cosmetics are hardened, thereby losing the inherent function. Thus, there is a need to a method of preventing the volatile materials of cosmetics from being volatilized. To solve the above-described problems, as shown in FIG. 2, an airtight cosmetic container is disclosed in Korean Registered Patent No. 10-1297824, where a sealing rib 3 is formed on a lower portion of a packing case lid such that the sealing rib 3 is inserted into a packing groove formed in a packing case 2, so that the packing case 2 is effectively sealed, thereby preventing the volatile materials of cosmetics from being volatilized. However, according to the related art, to refill the cosmetics, after the packing case 2 is separated from an outer container, the packing case lid is opened to separate a fixing member 4. Then, after an inner container 5 is changed for a new inner container 5, the inner container 5 must be assembled in a reverse sequence again. Thus, since several components must be separated and assembled again to exchange the inner container 5, the refill process is inconvenient. In addition, according to the related art, since the fixing member 4 for fixing the impregnation member is separately formed while covering an upper part of the inner container 5, the number of assembling components is increased so that the manpower for assembly is increased, thereby deteriorating the productivity and increasing the component prices. In addition, according to the related art, when the inner container 5 is made of synthetic resin, the inner container 5 made of synthetic resin is required to have a constant thickness or above, so that the cosmetic containing space is reduced, so it is limited to maximize the amount of cosmetics filled in the inner container 5.

The influence of genetic changes in body weight, egg production, and body conformation on organ growth of turkeys. Measurements were made on the breast with bone (BWB), a demand organ, and various supply organs in mature turkeys (approximately 40 wk of age) from various lines of turkeys to determine the influence of selection for increased egg production, BW, and body conformation on resource allocation. Comparisons made were: 1) a line (E) selected long-term for increased egg production and its randombred control (RBC1); 2) a line (F) selected long-term for increased 16-wk BW and its control (RBC2); 3) the F line with a commercial sire line (C); and 4) the RBC1 line and a randombred control (RBC3) that was formed from the F and C lines. Data were analyzed on an absolute basis and after adjustment to a common BW by covariance analysis. The only major change in organ sizes that occurred that could not be accounted for by differences in BW was in the E line. The actual and relative weights of total supply organs decreased and the relative weight of the BWB increased in the E line when compared with its randombred control. Selection for increased BW in the F line did not result in a relative change in BWB. The BWB weight was relatively heavier in the C line than in the F line. The relative amount of BWB was slightly but significantly different in the two randombreds (RBC1 and RBC3) formed 29 yr apart. Weight of the gizzard did not increase at the same rate as BW in two large-bodied lines (F and RBC3).

Granzyme B, a new player in activation-induced cell death, is down-regulated by vasoactive intestinal peptide in Th2 but not Th1 effectors. Following antigenic stimulation and differentiation, Th1 and Th2 effector cells contribute differently to cellular and humoral immunity. Vasoactive intestinal peptide (VIP) induces Th2 responses by promoting Th2 differentiation and survival. In this study, we investigate the mechanisms for the protective effect of VIP against activation-induced cell death (AICD) of Th2 effectors. Surprisingly, microarray and protein data indicate that VIP prevents the up-regulation of granzyme B (GrB) in Th2 but not Th1 effectors. This is the first report of GrB expression in Th cells and of its involvement in activation-induced apoptosis. The enhanced responsiveness of Th2 cells to VIP is probably due to the higher expression of VIP receptors. The effect of VIP on Th2 survival and GrB expression is mediated through the VIP receptors 1 and 2 and cAMP signaling through exchange protein activated by cAMP and, to a lesser degree, protein kinase A. In addition to effects on GrB, VIP also down-regulates Fas ligand (FasL) and perforin (Pfr) expression. The extrinsic Fas/FasL pathway and the intrinsic GrB-dependent pathway act independently in inducing AICD. The mechanisms by which GrB induces cell death in Th1/Th2 effectors include both fratricide and suicide. Fratricide killing, prevalent in wild-type cells, is calcium and Pfr dependent, whereas the cell death of Pfr-deficient Th cells involves Fas and GrB but is calcium independent. This study identifies GrB as a new significant player in Th1/Th2 AICD and characterizes two mechanisms for the protective effect of VIP on Th2 survival, i.e., the down-regulation of GrB and FasL expression.

Reporting guidelines in health research: A review. Contemporary health research has come under close scrutiny, exposing alarming flaws in the reporting of research. The reporting guidelines can aid in identification of poorly reported studies and can bring transparency to health research. The guidelines also help journal editors, peer reviewers, funding agencies, and readers to better discern health research. Reporting guidelines encourage accurate and thorough reporting of fundamental aspects of health research so that the results of studies can be replicated by others. Reporting guidelines are potent tools to improve the practice of research and in reducing reporting bias. For the present review, both electronic and manual literature search was carried out. Electronic databases like PubMed, MEDLINE, EBSCO host, and Science Direct were searched for extracting relevant articles. Various key words and their combinations were used for literature search like reporting guidelines, checklist, research, publishing standards, study design, medicine, and dentistry. The search results were scrutinized for relevance to the topic and only full text articles in English were incorporated. Various reporting guidelines were identified and grouped under headings based on study design. This review article attempts to highlight the various reporting guidelines in literature relating to health research, its potential applications, and its limitations.

What do clients expect of community care and what are their needs? The Community care for the Elderly: Needs and Service Use Study (CENSUS). To investigate the relationship between objectively assessed care needs and expectations for care of older people and their carers, before commencement of community care services. Cross-sectional research on 55 community-dwelling older adults and carers, recruited after receiving approval for government-subsidised community care services. Care needs and expectations of care were assessed at interview. Participants' and carers' expectations for their pending community care package did not correspond with unmet participant needs. Instead, expectations corresponded with met needs, that is those for which they already received help, with the exception of expectations of domestic support and personal care. Participants' unmet needs were predominantly in social and recreational activities, eating, and physical and mental health. As community care in Australia becomes consumer-directed by 2015, care services will need to empower clients and carers through education about their needs and available services, as part of the assessment and service negotiation process.

Static equipment including electronic components is now extensively used in telephone exchanges together with traditional electromechanical relay contacts to produce ringing signals (usually of 25 Hz) transmitted over subscriber lines to respective stations in response to digit-selection signals received by the exchange from calling subscribers. In the present state of the art, a ringing-signal generator normally comprises a pilot oscillator working into an amplification stage stabilized by negative feedback, the amplifier furnishing an output signal of the desired power characteristics. Two disadvantages of this arrangement are the low efficiency of such an amplifier and the large-size output transformer required to raise the voltage of the outgoing signal. Another conventional ringing-signal generator produces a stepped wave approximating a sinusoid, e.g. by connecting different taps of a transformer secondary in cyclic succession to an amplifier, this stepped wave being fed to a low-pass filter stage deriving a roughly sinusoidal voltage therefrom. Although such a device performs satisfactorily, the harmonics content of its output voltage is significant even with a high number of steps in the unfiltered waveform. Another shortcoming of the last-mentioned device is its relative inflexibility in the face of variations in load.

The work in this laboratory includes three major projects: (1) Studies involve an assessment of cell-mediated immune responses after the host has responded to a variety of alloantigenic stimulation to the same and other antigens. The significance of this work comes from attempts to understand regulatory mechanisms of cellular immune responses. This work has resulted in the development of a new mechanism of T cell control - the alloantigen elimination hypothesis. (2) Studies on the use of activated killer cells in the destruction of tumor cells have been undertaken. The receptor on tumor cells for killer lymphocytes is the subject of current investigation. An adjuvant immunotherapy attack on cancer cells remaining after surgery is planned using cells activated in vitro to lyse tumor cells. (3) A new mechanism of specific suppression to facilitate the transplantation of tissue and skin allografts is being attempted. The use of antigen specific suicide with 3H-Thymidine to produce clonally depleted cell populations is under investigation.

Incorporation of nickel into ruminal factor F430 as affected by monensin and formate. A mixed culture of ruminal microorganisms was used to demonstrate that nickel (Ni) is incorporated into factor F430 and to determine the effects of monensin and formate on incorporation of Ni into factor F430. Ruminal microorganisms obtained from a semicontinuous culture were grown for 24 h in the presence of 63Ni and a 2 x 2 factorial arrangement of monensin (0 to 5 micrograms/ml) and formate (0 to 20 mM) treatments. Factor F430 was isolated and purified from the cultures by QAE-Sephadex A-25 column chromatography. The purified preparation contained 63Ni and exhibited a peak in absorbance at 430 nm. Methane production was decreased (P less than .01) 45% by monensin but was increased (P less than .01) 1.8-fold by formate. However, incorporation of 63Ni into factor F430, which is ubiquitous in methanogens and not found in other bacteria, did not parallel changes in methane production. Incorporation of 63Ni into factor F430 was decreased (P less than .01) 55% by monensin but was not affected (P greater than .05) by formate. In addition to its use for synthesis of urease and hydrogenase, Ni is involved in ruminal fermentation as a component of factor430.

Social class inequalities in the utilization of health care and preventive services in Spain, a country with a national health system. In Spain, despite the existence of a National Health System (NHS), the utilization of some curative health services is related to social class. This study assesses (1) whether these inequalities are also observed for preventive health services and (2) the role of additional private health insurance for people of advantaged social classes. Using data from the Spanish National Health Survey of 2006, the authors analyze the relationships between social class and use of health services by means of Poisson regression models with robust variance, controlling for self-assessed health. Similar analyses were performed for waiting times for visits to a general practitioner (GP) and specialist. After controlling for self-perceived health, men and women from social classes IV-V had a higher probability of visiting the GP than other social classes, but a lower probability of visiting a specialist or dentist. No large class differences were observed in frequency of hospitalization or emergency services use, or in breast cancer screening or influenza vaccination; cervical cancer screening frequency was lower among women from social classes IV-V. The inequalities in specialist visits, dentist visits, and cervical cancer screening were larger among people with only NHS insurance than those with double health insurance. Social class differences in waiting times were observed for specialist visits, but not for GP visits. Men and women from social classes IV-V had longer waits for a specialist; this was most marked among people with only NHS insurance. Clearly, within the NHS, social class inequalities are still evident for some curative and preventive services. Further research is needed to identify the factors driving these inequalities and to tackle these factors from within the NHS. Priority areas include specialist services, dental care, and cervical cancer screening.

Characterization of a new functional TCR J delta segment in humans. Evidence for a marked conservation of J delta sequences between humans, mice, and sheep. Through analysis of TCR delta-chain cDNA derived from human gamma delta T cell clones and polyclonal gamma delta T cell lines, we isolated a novel functional J delta gene segment (termed J delta 4) whose genomic fragment has been mapped within the TCR-delta locus between J delta 2 and J delta 1. Frequency of J delta 4 use was estimated among adult gamma delta PBL by using V delta 1, V delta 2, and V delta 5 genes. In all cases, this new J element was used at a low, albeit significant frequency, close to that of J delta 2. Finally, like human J delta 1 and J delta 2, which show a high degree of homology with their counterparts in the mouse and sheep, but unlike other J gamma, J beta, or J alpha elements, J delta 4 turned out to be highly homologous to a recently described ovine J delta. These results suggest the existence of strong selective pressures, possibly linked to an Ag-driven process, leading to specific conservation of J delta sequences among these three species.

Analysis of clinical characteristics, rationale, and management of critically ill obstetric patients transferred to ICU. To evaluate the clinical and demographic characteristics, rationale for transfer of critically ill obstetric patients to intensive care unit and their management therein. The observational retrospective case series study was conducted at Shaheed Mohtarma Benazir Bhutto Medical University, Larkana, Pakistan, and comprised critically ill female patients transferred to intensive care unit from the department of Obstetrics and Gynaecology between August 2011 and June 2013. The data was collected on pre-designed proforma which included demographic characteristics of patients, their symptomatology and initial diagnosis, intervention in the department, continuing or subsequent complications/reasons for admission to intensive care unit, management and stay there and, finally, outcome. Data was analysed using SPSS 21. The mean age of 150 patients in the study was 30.3±5.047years,mean parity was 2.49±2.207.The most common condition affecting women and leading to their transfer to intensive care was eclampsia/pre-eclampsia in 80(53.33%) followed by bleeding disorders in 25(16.65%) and septic shock in 24(16%). The mean stay in intensive care was 4.47±2.53 days, and 38(25.3%) patients required ventilator support, while 112(74.7%) were managed with oxygen and inotropic support. The overall maternal mortality rate was 41(27.3%), which included 19(16.9%) patients managed without ventilator, and 22 (57.8%) managed with ventilator (p<0.05). Hypertensive and bleeding disorders were the main reasons for transfer of obstetric patients to intensive care unit, and maternal mortality was high among patients treated on ventilator support.

Natural occurrence of acetylated derivatives of deoxynivalenol and nivalenol in wheat and barley in Japan. Thirty-four samples of domestic wheat and barley grains, collected from eight prefectures of different locations in Japan and previously determined to be positive for deoxynivalenol (DON), nivalenol (NIV) and/or zearalenone (ZEA), were analysed for acetylated derivatives of DON and NIV by gas chromatography-mass spectrometry. In addition to DON and NIV, 3-acetyldeoxynivalenol (3-ADON), 15-acetyldeoxynivalenol (15-ADON) and 4-acetylnivalenol (4-ANIV) were found in 25, 4 and 14 samples, respectively. A regional difference in the DON and NIV contamination of Japanese wheat and barley was suggested: DON was the major trichothecene in the northern district and NIV in the central districts, whereas in the southern districts the DON level was similar to or slightly higher than the NIV level. 3-ADON occurred together with DON in almost all prefectures examined, whereas 15-ADON was found only in samples from northern districts. In addition, a high correlation (r = 0.974, n = 23) between levels of DON and its acetates (3-ADON and 15-ADON) was noted. These results may also suggest the possibility of a geographic difference in the distribution of different chemotypes of Fusarium species producing these trichothecenes in Japan.

[Scintigraphy by l'Octreoscan in the management of head and neck paragangliomas]. To assess the usefulness of somatostatin receptor scintigraphy [Octreoscan] in a series of 18 patients referred for a suspicion of paraganglioma of the head and neck between July 2001 and February 2002. Sixteen patients had one or several paragangliomas of the head and neck diagnosed on conclusive conventional imaging including CT and MR scan. In two patients, radiological data were not conclusive. Planar images were obtained 4 and 24 hr after the iv injection of 148-185 MBq [Octreoscan]. Twenty-two hot spot lesions were detected. Twenty of these lesions corresponded to the twenty known paragangliomas. The volume of the smallest tumor was 0.2 cm(3). In one patient, intense thyroid nodule uptake led to the surgical diagnosis of oncocytoma. In two lesions, where conventional imaging was not conclusive, arteriography showed a typical aspect of meningioma; one patient was operated on and histology confirmed this diagnosis. No evidence of abnormal uptake was seen in site previously operated on (3 patients). Octreotide scintigraphy is a very sensitive method for detection of paraganglioma of head and neck. It provides information on potential tumor sites in the whole body after one single injection. It could be used as a screening test in patients at risk (familial or known paraganglioma) in order to detect paraganglioma at an early stage and, thus to reduce the surgical morbidity, as well as in the follow-up after surgery to detect recurrences.

Various types of software development applications exist that software developers may use to develop software. An integrated development environment (IDE) is a type of software development application that contains several development tools in one package. An IDE may include tools such as a source code editor, a build automation tool, and a debugger. Examples of IDEs include Eclipse™ developed by Eclipse Foundation of Ottawa, Canada, ActiveState Komodo™ developed by ActiveState of Vancouver, Canada, IntelliJ IDEA developed by JetBrains of the Czech Republic, Oracle JDeveloper™ developed by Oracle Corporation of Redwood City, Calif., NetBeans developed by Oracle Corporation, Codenvy™ developed by Codenvy of San Francisco, Calif., Xcode® developed by Apple Corporation of Cupertino, Calif., and Microsoft® Visual Studio®, developed by Microsoft Corporation of Redmond, Wash. Code optimization refers to a method of code modification that improves code quality and/or efficiency. A program may be optimized so that it becomes a smaller size, consumes less memory, executes more rapidly, or performs fewer input/output operations. Code optimization may be performed, for example, by a specialized software tool or a built-in unit of a compiler (a so-called “optimizing compiler”). Code optimization is used in the development of many types of applications, including the development of video games, where developers may generate optimized builds in daily use (primarily for performance reasons). An optimized build results in machine code that is semantically equivalent to machine code generated without optimizations, but is configured in a way that fewer resources are used during execution of the optimized machine code (e.g., less memory, fewer procedure calls, etc.). As noted above, many developers use optimized build configurations for their daily developer build scenarios. This is a very common practice for game developers, who need their games to run at a particular speed to add visual effects, etc. Due to the introduction of certain optimizations (e.g., inlining, register allocation, common subexpression elimination, etc.), it is common for a developer that is debugging optimized code to observe a hopping program counter (the program counter jumps around in a manner that is not sequential), cross-jumping, the well-known roving variable phenomenon (e.g., a variable might be dead and its register is reused, assignment to a variable has been moved etc.), as well as other undesired phenomenon. Thus, such optimizations can make debugging the optimized code a difficult and frustrating experience for the average developer.

When high-speed and low voltage swing data transfer is needed, differential signaling (also commonly referred to as double ended signals), wherein signals are carried on two conductors and the signal is defined as the difference in the two signals. Differential signaling is perhaps the most robust and promising signaling concept. Current mode logic (CML), a design technique commonly used in high speed signaling applications such as communications chips and routers, uses differential signaling. CML is widely used in high-speed applications due to its relatively low power consumption and low supply voltage when compared to other types of logic, such as emitter coupled logic (ECL). CML is also considerably faster than CMOS logic due to its lower voltage swings. CML also has an added advantage of the capability of being fabricated using CMOS fabrication technology. When a signal needs to be transmitted off-chip, a signal driver commonly referred to as an off chip driver (OCD) may be used. An OCD may be used to provide sufficient driving current in order to transmit the signal on a transmission line. Certain OCDs may also provide voltage compatibility conversions. In a CML OCD, resistors are used to provide a necessary voltage drop that is necessary to the operation of the CML circuit. When a signal is received over a transmission line, it is desired that the transmission line be properly terminated with resistors of a desired value so that the optimum signal transfer be achieved. In most situations, the resistors will have the same value (or approximately the same value) as the resistance seen by the signals being transmitted over the transmission line. These termination resistors are commonly referred to as on die termination (ODT) resistors. Unless a particular application communicates in only one direction (either transmit or receive), a typical solution would be to have separate OCD and ODT circuits for each transmission line used in the application. One disadvantage of the prior art is that through the use of separate OCD and ODT circuits, more resistors are used. In integrated circuits, it can be relatively difficult to produce resistors of a specific desired value, especially if the resistance of the resistors is large. This may lead to a more expensive integrated circuit. A second disadvantage of the prior art is that integrated resistors (especially resistors with large resistances) may be physically large in size. Therefore, the use of a relatively large number of resistors may result in an integrated circuit that is physically large. Additionally, the presence of the large resistors may make it more difficult to route and place circuitry in the integrated circuit.

The long-term goal of this proposal is to elucidate the molecular basis of embryonic endoderm development in vertebrates. The endoderm layer of the embryo gives rise to the epithelial lining of the gastrointestinal tract, liver, lungs, pancreas, thyroid and thymus, but our understanding of endoderm formation lags behind that of mesoderm and neural development. The framework of a conserved molecular pathway that initiates endoderm development has recently been deduced. The endoderm specific transcription factor Sox17 is one of the most downstream components of this pathway and while the evidence suggests that it has a critical function, its precise role has not been determined. Furthermore, the molecular cascade downstream of Sox17 that directs endoderm differentiation is unknown. This proposal focuses on the role of Sox17 using Xenopus as a model system. In our published work and preliminary experiments we have discovered that Sox17 functionally interacts with the Wnt and TGF signaling pathways. We have identified direct target genes of Sox17 and our data suggests that beta-catenin and Smad2 are important transcription partners of Sox17. This proposal seeks to extend our understanding of Sox17 function and endoderm development with the following specific aims: 1. To better characterize the role of Sox17 in endoderm formation. 2. To determine the function of several Sox17 target genes. 3. Examine how Sox17 interacts with the Wnt and TGF pathways to regulate endodermal genes. 4. Determine the molecular basis of Sox17's interaction with beta-catenin and Smad2. This research will further our understanding of endoderm development and how Sox, Wnt and TGF pathways are regulated. This information will be useful for directing the differentiation of stem cells along endodermal lineages. It may also provide insight into congenital diseases or cancers associated with defects in endoderm development, as well as mutation in Sox proteins, Wnt and TGF signaling components.

The present invention relates to keyswitches for use in computer terminals, typewriters, and the like and more particularly to an actuator assembly for use in a linear feel keyswitch with hysteresis which includes three separate spring elements. Keyswitches of conventional design generally include a plunger which is slideably mounted within a housing. The plunger is designed to slide downwardly when the keytop of the keyswitch is pressed. Downward pressure on the keytop actuates an electrical switch coupled to the plunger. For certain applications, it is desirable to have a keyswitch which provides a linear feel to the keyswitch operator. It is also desirable to provide a keyswitch with hysteresis and overtravel. In a keyswitch with linear feel, the amount of force required to press the switch from its non-actuated to its fully depressed condition increases linearly as the plunger travels downwardly. In a keyboard, such as a typewriter keyboard manufactured from a plurality of keyswitches, the provision of linear feel reduces fatigue on the fingers of the keyboard operator. The use of linear feel keyswitches also increases accuracy by providing a certain degree of feedback to the keyboard operator and facilitates the efficiency of keyboard operation. The provision of hysteresis in a keyswitch results in a lag in the electrical response of the switch. For example, if the point at which a keyswitch "makes" an electrical connection on the downward stroke of the plunger is further down than the point at which the electrical connection "breaks" on the upward stroke, the switch is said to have a positive hysteresis. If the make and break points in the switch are at the exact same physical location on the downward and upward strokes (i.e., no hysteresis), it will be possible for a keyswitch operator to unintentionally produce multiple actuations if any hesitation is made at the exact moment the switch turns on. This phenomenon is known as "teasing" the switch, because what is intended by the operator as one switch actuation may be interpreted by the circuitry actuated by the switch as a plurality of actuations. Where the switch is designed such that it must pass through the make point on its return stroke before the break point is reached, such teasing, with the resultant possibility of error, will be prevented. Hysteresis can be provided by either electrical means, mechanical means, or both. For example, hysteresis can be provided electrically in a capacitive-type keyboard by using an electronic circuit with different thresholds for "make" and "break" to detect the keyboard output. If the electronic circuit senses an incremental change in capacitance of 8 picofarads ("pf") from a threshold value as a make condition and an incremental capacitance change of 5 pf from the same threshold value as a break condition, then the plungers of the keyswitches on the keyboard will have to pass through the make point on their return stroke before reaching the break point. Thus, positive hysteresis will be achieved. Mechanical hysteresis can be provided by mechanically establishing a different plunger displacement for the make point and the break point. It has now been found that the use of a plunger using three spring elements, where one spring element is a resilient foam switch actuator, provides a significantly improved positive mechanical hysteresis. This result occurs even though the resilient foam itself has a force versus displacement profile indicative of a negative hysteresis. Spring elements other than resilient foam, which exhibit negative hysteresis, can alternatively be used. For example, a plunger having two spring elements, in conjunction with the spring force provided by a momentary contact membrane-type keyswitch well known in the art, can provide an improved positive mechanical hysteresis in accordance with the present invention. In such an arrangement, the plunger with two spring elements would be used to actuate the membrane-type switch. In a keyswitch with overtravel, electrical contact is made (i.e., the switch turns "on") before the keytop is fully depressed. Overtravel provides for more reliable switch operation, because keyboard operators often inadvertently fail to press the keyswitch down the whole way, particularly when typing at a high rate of speed. When overtravel is provided, the keyswitch will turn on as long as the plunger is depressed at least to the point where electrical contact is made. It would be advantageous to provide a keyswitch combining the favorable characteristics of linear force, hysteresis, and overtravel. The present invention relates to such a keyswitch.

This invention relates generally to the field of alert systems and, in its preferred embodiments, to alert systems utilizing cellular, personal communication system, or wireless telecommunication technology to deliver an alert to a person. In recent decades, the science of meteorology has advanced rapidly, allowing increasingly accurate detection and prediction of severe and hazardous weather. Specifically, Doppler radar systems and high resolution satellites have been developed which allow early detection of tornadoes and severe thunderstorms and accurate tracking of their paths. The National Weather Service (NWS) and National Oceanographic and Atmospheric Administration (NOAA) now routinely issue warnings in advance of most severe or tornadic storms, alerting individuals and saving lives. However, in order for these warnings, or xe2x80x9calertsxe2x80x9d to be effective, they must be communicated to and received by their intended recipients. Some local governments and municipalities utilize civil defense siren systems to provide warnings to persons within the localized range of the siren systems in case of severe weather, natural disaster, war or other emergency conditions. However, weather-related warnings are more commonly provided through the NOAA Weather Radio system which is a nationwide network of radio stations operating twenty-four (24) hours per day to broadcast continuous weather information directly from the local offices of the National Weather Service. The NOAA Weather Radio system also broadcasts alerts for the Emergency Alert System (EAS), maintained by the Federal Communication Commission, in order to provide emergency warnings for all types of hazards, including, but not limited to, earthquakes, volcano erruptions, severe weather and nuclear war. The NOAA Weather Radio system has more than 450 transmitters, covering broad areas in each of the 50 states, adjacent coastal waters, Puerto Rico, the U.S. Virgin Islands, and the U.S. Pacific Territories. Unfortunately, reception of the Emergency Alert System warnings via the NOAA Weather Radio system generally requires a special radio receiver or scanner capable of picking up its emergency warning signals. Tone-activated alert receivers are commonly used to monitor NOAA Weather Radio broadcasts, to provide warning of severe weather and to provide emergency and civil defense alerts. A tone-activated alert receiver constantly monitors the local NOAA Weather Radio broadcasts for a specific 1050 Hz emergency alert tone. In response to receiving an emergency alert tone, a tone-activated alert receiver produces an audible and/or visual alarm, and activates a radio tuned to the NOAA Weather Radio broadcast. Since each NOAA Weather Radio station transmits its signals to a relatively large geographical area, older tone-activated alert receivers suffer from the disadvantage of falsely responding to alerts when the condition to which the emergency alert pertains is only relevant to other geographical areas in the broadcast area of the particular NOAA Weather Radio station transmitting the alert tone. Newer NOAA Weather Radio receivers, known as xe2x80x9cSAME receiversxe2x80x9d, incorporate a feature known as Specific Area Message Encoding (SAME) to decrease the frequency of false alerts. A SAME receiver recognizes a specific digital location code, in an emergency broadcast signal, which designates a specific locality for which alerts are relevant. Once programmed by a user to respond only to a specific digital location code for the area of the user, a SAME receiver switches into alarm mode only upon receipt of an emergency broadcast signal which includes a SAME digital location code matching the preprogrammed digital code. Accordingly, SAME receivers are generally deployed in a particular, fixed location such as an individual""s home or office. While these SAME receivers are useful in their fixed locations, they are not particularly useful if moved from the location for which they have been programmed. Additionally, like many individuals who cannot program a video cassette recorder (VCR), some individuals may find it difficult or inconvenient to program the SAME receiver. As an alternative to SAME receivers, some persons are proposing that cellular or Personal Communication System (PCS) wireless telephone networks be employed to deliver emergency alerts to individuals having cellular or PCS wireless telephones because cellular and PCS telephone networks typically employ short-range, broadcast transceivers (or transmitters) which have coverage areas, or cells, of a reasonably small size, thereby enabling the delivery of emergency alerts to persons in selected areas served by particular broadcast transmitters. As proposed, delivery of emergency alert messages to selected local areas would be achieved by activating only those cellular or PCS broadcast transceivers providing coverage for the specific geographical area to which the emergency alert is relevant, instead of requiring the transmission, preprogramming, and recognition of a specific digital location code corresponding to the geographical area for which the emergency alert is relevant. However, until recently, wireless telephone networks have not had the capability of transmitting alphanumeric messages that would be required to effectively distribute emergency alert messages. In contrast, conventional paging systems have the capability of supporting alphanumeric messaging, but have coverage areas far to large to provide the level of geographical specificity required to deliver location specific, emergency alert messages. New cellular and PCS telephone networks are currently being deployed, or have been deployed, throughout North America and Europe which are capable of transmitting alphanumeric messages and which have coverage areas providing sufficient geographical specificity to make them ideal vehicles for the delivery of location-specific, emergency alert messages. Using the newer cellular and PCS networks, a network operator can send messages to a cellular or PCS telephone present in any single cell or any group of cells serviced by the transceivers of the network. Accordingly, some persons have recently proposed that these cellular and PCS networks be used to transmit location-specific, emergency alert messages to the cellular or PCS telephone handsets of individual users by dialing the telephone number associated with each handset and, upon answer by the cellular or PCS handset, delivering the emergency alert message to the handset. While cellular or PCS telecommunications systems may be an effective vehicle for conveying location-specific, emergency alert messages, such systems enable delivery of emergency alert messages to only those individuals who can figure out how get such messages via their wireless telephones. Currently, to get such messages, individuals must find their way through a myriad of icons (which many individuals cannot do) and then review all of their messages in order to identify the emergency alert messages from other messages. Further, the delivery of emergency alert messages via cellular or PCS telecommunications systems requires individuals to have their handsets nearby and turned-on (and not depleted of battery power). Unfortunately, individuals often turn-off their handsets, forget to recharge them, or leave their handsets, for instance, in the car while they are at home or work. As a result, a system that relies upon cellular or PCS handset receivers to receive emergency alert messages may fail to notify a large number of individuals of the existence of an emergency condition. Other similar difficulties are inherent in the delivery of information or messages that relate to military or other operations (i.e., a different type of xe2x80x9calertxe2x80x9d). For instance, if a branch of the military needs to inform its reservists to report for duty on Sunday instead of Saturday as the reservists were originally notified, it typically contacts each reservist individually by telephone to provide the reservist with such information, thereby requiring a substantial use of labor to perform such a task. Therefore, there is a need in the industry for an apparatus and method whereby individuals may reliably receive cellular or PCS transmissions of location-specific alert information without requiring the use of a cellular or PCS telephone handset. Furthermore, there is a need for an apparatus and method whereby individuals may reliably receive cellular or PCS transmissions of location-specific alert information without requiring individuals to perform complex retrieval steps or inconvenient receiver programming steps. Briefly described, the present invention comprises an alert apparatus and method for receiving a location-specific alert (i.e., an alert directed and relevant to a particular geographical area) and for informing a user, who may be visually or hearing impaired, of the existence and severity of the alert. More particularly, the present invention includes an alert apparatus and method which allow a user to receive data corresponding to an alert which has been broadcast via particular transmitters operating within a cellular, PCS, or wireless telephone communications network, thereby allowing receipt of a location-specific alert (and a textual message associated with the alert) without requiring the user to input, to the alert apparatus, data representative of or identifying the location of the apparatus. Further, the present invention includes an alert apparatus and method which produces high-decibel level audible sounds and high-intensity flashing strobe light corresponding to alerts of the most severe level and which produces low-decibel level audible sounds and low-intensity flashing light from a light-emitting diode corresponding to alerts of a less severe level. In accordance with the preferred embodiment, the apparatus of the present invention comprises an alert device having a microcomputer that directs operation of the alert device according to the instructions of a computer software program stored therein. The alert device also includes a receiver that receives digital PCS transmissions broadcast over a PCS or cellular telecommunication network. The microcomputer has a central processing unit and a monitoring circuit communicatively connected to the central processing unit and receiver. The monitoring circuit is capable of setting the receiver to receive transmissions, if any, on radio channels identified by the central processing unit, of determining the signal strength associated with transmissions received on such radio channels, of identifying the presence of a digital control channel on a radio channel, and of communicating signal strength information, digital control channel information, and broadcast short messages, received by the receiver, to the central processing unit. According to the preferred embodiment of the present invention, the alert device further comprises a plurality of peripheral devices and the microcomputer further comprises a peripheral device controller which connects to the plurality of peripheral devices. The plurality of peripheral devices includes a liquid crystal display, a high-level audio speaker, a low-level audio speaker, a high-intensity strobe light, and a low-intensity light-emitting diode. The microcomputer, via the peripheral device controller, controls the operation of the plurality of peripheral devices according to the severity of a condition identified by an alert. For instance, the microcomputer causes the production of audible sound from the high-level audio speaker-at a high-decibel level and flashing of the high-intensity strobe light to warn a user of the existence of a xe2x80x9cLevel Onexe2x80x9d alert (i.e., the most severe or important alert condition). Similarly, the microcomputer causes the production of audible sound from the low-level audio speaker at a low-decibel level and flashing of the low-intensity light-emitting diode to warn a user of the existence of a xe2x80x9cLevel Twoxe2x80x9d alert (i.e., a less severe or less important alert condition). The microprocessor, via the peripheral device controller, also causes the display, on the liquid crystal display, of textual information received as part of an alert message. The alert device, in accordance with the preferred embodiment, is operable to continuously monitor broadcasts from a cellular, PCS, or wireless telecommunications network. Accordingly, the alert device connects to an electrical outlet to receive electrical power for normal operation, but includes a battery backup and charging circuit to ensure operation of the alert device even in the event of a power failure. Furthermore, in the preferred embodiment, the alert device operates continuously when supplied with electrical power, has no on/off switch, and thus cannot easily be deactivated by a user unlike a cellular or PCS telephone handset. The alert device does, however, include a reset pushbutton that enables a user to temporarily deactivate, or stop, the audible and visual alarms once notified of an alert condition. In the preferred embodiment, the alert device is mountable to an electrical wall socket in a manner substantially similar to that of a conventional smoke detector. In an alternate embodiment, the alert device has an enclosure that enables the device to reside atop a table or other surface in a manner substantially similar to that of a weather radio. In an alternate preferred embodiment, the alert device includes a plurality of peripheral devices that are locatable at sites remote from the alert device. In accordance with a method of the preferred embodiment of the present invention, the alert device operates according to the instructions of a computer software program residing in the microcomputer and performs a self-test when powered-up to determine whether the alert device is functioning properly. The alert device, through cooperation between the microcomputer, monitoring circuit, and receiver, then scans a factory-set, pre-identified set of radio channels comprising a range of channels used by compatible cellular or PCS telecommunication networks in order to identify the channel associated with the cellular or PCS transmitter which transmits on a digital control channel and which has the strongest signal strength at the location of the alert device. The alert device then locks onto and passively monitors the selected channel for digital alerts in the form of broadcast short messages. Because the alert device passively monitors PCS network broadcasts, use of the alert device should not result in the user incurring periodic service charges from the network provider. According to the method of the present invention, the alert device, upon detecting and receiving a broadcast short message, identifies whether the broadcast short message comprises an alert message. If so, the alert device then analyzes the alert message and determines the severity level of the alert identified by the alert message. If the alert is a xe2x80x9cLevel Onexe2x80x9d alert, the alert device operates, as described above, the high-level audio speaker to produce a highly obtrusive, high-decibel level sound substantially similar to that of a conventional smoke detector (i.e., a sound that would cause even the hardest of sleepers to awaken) and the high-intensity strobe light to produce flashing, high-intensity, bright light. If the alert is a xe2x80x9cLevel Twoxe2x80x9d alert, the alert device operates, as described above, the low-level audio speaker to produce a less-obtrusive, low-decibel level, xe2x80x9cchirpingxe2x80x9d sound and the low-intensity light-emitting diode to produce less-intense, less-bright, flashing light. Regardless of the severity level of the alert, the alert device extracts textual message information, if any, from the alert message and displays the textual message information on the liquid crystal display to provide a user with a more detailed explanation as to the nature of the alert. Once the user is informed as to the existence and nature of the alert, the production of audible sounds and the generation of flashing light is terminable by the user through depression of the reset pushbutton protruding partially from the alert device. In accordance with an alternate preferred embodiment of the present invention, the alert device is operable with an alert messaging system of a service provider which provides different levels of service (i.e., service levels or modes) to a user of the alert device in exchange for a subscription fee paid to the service provider by the user. The plurality of service levels or modes enable different classifications of alert messages to be related to and associated with the subscription status of a user (i.e., the service level selected by, subscribed to, and paid for by a user). Based upon the service level selected by the user and stored in a service level data element of the user""s alert device, the user""s alert device will provide that level of service to the user. For example and not limitation, a user may select a service level from any of the following levels: fully enabled; partially enabled; or, fully disabled. The user pays a subscription fee to the service provider in an amount determined by the selected service level, and the service provider causes a service level data element stored at the user""s alert device to be set to a value indicating the service level or mode selected by the user. Once set, the user""s alert device operates at the selected service level. In the fully enabled mode, the alert device reacts to all alert messages and provides the user with any received information pertaining to the corresponding alert. In the partially enabled mode, the alert device only reacts to the most severe alerts (i.e., xe2x80x9cLevel Onexe2x80x9d alerts) to provide subscribers with a minimal level of service and warnings. In the fully disabled mode, the alert device does not react to any alerts. Such operability allows a service provider of alert messages to establish and enforce compliance with a subscription system. According to another alternate preferred embodiment of the present invention, the alert device is operable with an alert messaging system of a service provider which provides a service level that enables the user""s alert device to receive and react to an advertisement that is present in the body of an alert message. In operation, the service provider causes a service level data element stored at the user""s alert device to be set to a value indicating that the user""s alert device is to display received advertisements on the device""s display. Then, whenever the alert device receives a short message having a service level with that value, the alert device extracts an advertisement from the body of the message and displays it on the alert device""s display. Accordingly, it is an object of the present invention to provide an apparatus and method for receiving location-specific alert information without requiring a user to input data representative of the user""s location. Another object of the present invention is to provide an apparatus and method for receiving location-specific alert information that is not limited to a fixed location. Still another object of the present invention is to provide an apparatus for receiving location-specific alert information that can be moved from an old location to a new location without requiring reprogramming or the input of data representative of the new location. Still another object of the present invention is to provide an apparatus for receiving location-specific alert information that self-identifies the strongest source of such alert information. Still another object of the present invention is to provide an apparatus for receiving location-specific alert information that self-identifies the frequency on which the alert information is transmitted or broadcast. Still another object of the present invention is to provide an apparatus and method for receiving location-specific alert information that identifies the different levels of severity associated with alerts. Still another object of the present invention is to provide an apparatus and method for receiving location-specific alert information that produces different sensory outputs corresponding to the different levels of severity or importance of alerts. Still another object of the present invention is to provide an apparatus and method for receiving location-specific alert information which operates continuously, unless moved by a user, at a particular location. Still another object of the present invention is to provide an apparatus and method for receiving location-specific alert information which is continuously operable from an external electrical power source and which has an internal battery backup for use during power failures. Still another object of the present invention is to provide an apparatus and method for receiving location-specific alert information which displays a textual message related to the alert for which the alert information pertains.

Shared File Systems (SFS) is a term applied to IBM's System/390 (S/390) system for sharing data among virtual machines. IBM's DB2 has been adapted for this type of data sharing in a Multiple Virtual Storage (MVS/Enterprise Systems Architectures (ESA) environment by using IBM's coupling facility to create multi-system data sharing. In such a shared system, when one of the systems fails, the update mode locks (data locks) that were held at the time of the failure are “retained” to prevent the other systems from accessing inconsistent data (data that had not yet reached a point of consistency at the time of the failure). To remove the retained data locks, the failed system's logs must be read in a forward and a backward direction in order to bring the data back to a point of consistency. Once this has been done, the retained locks can be removed, and the data is again accessible from all the systems. One conventional method generally employed to remove the retained locks when an operating system fails is the restart/recovery method. Utilizing the restart/recovery method, the failed system is restarted (either manually or automatically) on another operating system in the cluster and recovery logic is used to “recover” the data being protected by the retained data locks and bring the data back to consistency. The trouble with this approach is that in order to restart the failed system, a substantial amount of CPU resources could be utilized. Consequently, this use of CPU resources could impose a significant disruption to the work that is already running on the operating system. Accordingly, what is needed is a more efficient method and system for recovering the retained locks of the failed operating system. The method and system should be simple, cost effective and capable of being easily adapted to existing technology. The present invention addresses such a need.

Musa genetic diversity revealed by SRAP and AFLP. The sequence-related amplified polymorphism (SRAP) technique, aimed for the amplification of open reading frames (ORFs), vis-â-vis that of the amplified fragment length polymorphisms (AFLP) were used to analyze the genetic variation and relationships among forty Musa accessions; which include commercial cultivars and wild species of interest for the genetic enhancement of Musa. A total of 403 SRAP and 837 AFLP amplicons were generated by 10 SRAP and 15 AFLP primer combinations, of which 353 and 787 bands were polymorphic, respectively. Both cluster analysis of unweighted pair-grouping method with arithmetic averages (UPGMA) and principal coordinate (PCO) analysis separated the forty accessions into their recognized sections (Eumusa, Australimusa, Callimusa and Rhodochlamys) and species. The percentage of polymorphism amongst sections and species and the relationships within Eumusa species and subspecies varied between the two marker systems. In addition to its practical simplicity, SRAP exhibited approximately threefold more specific and unique bands than AFLP, 37 and 13%, respectively. SRAP markers are demonstrated here to be proficient tools for discriminating amongst M. acuminata, M. balbisiana and M. schizocarpa in the Eumusa section, as well as between plantains and cooking bananas within triploid cultivars.

Mitochondria-targeted redox probes as tools in the study of oxidative damage and ageing. Mitochondrial reactive oxygen species (ROS) and oxidative damage are associated with a range of age-related human pathologies. It is also likely that mitochondrial ROS generation is a factor in stress response and signal transduction pathways. However, current methods for measuring and influencing mitochondrial ROS production in vivo often lack the desired specificity. To help elucidate the potential role of mitochondrial ROS production in ageing, we have developed a range of mitochondria-targeted ROS probes that may be useful in vivo. This was achieved by covalently attaching a lipophilic cation to a ROS-reactive moiety causing its membrane potential-dependent accumulation within mitochondria. Mitochondria-targeted molecules developed so far include antioxidants that detoxify mitochondrial ROS, probes that react with mitochondrial ROS, and reagents that specifically label mitochondrial protein thiols. Here, we outline how the formation and consequences of mitochondrial ROS production can be investigated using these probes.

The present invention relates to power distribution systems. More specifically, the present invention relates to synchronous frame regulation in a power distribution system. It is not unusual for a power distribution system to have a three-phase distribution feeder that supplies multiple loads. However, different loads connected to the feeder can cause the line voltage to become unbalanced. The voltage is considered unbalanced if the line-to-line voltages are not equal. For instance, consider a situation when a three-phase motor and a single-phase load are connected to a distribution feeder line. If the three-phase motor and the single-phase load are operated at the same time, a voltage unbalance on the feeder line will occur. When an unbalanced voltage is applied to an active rectifier, control algorithms used to regulate the active rectifier can cause third harmonic current to be generated in the power distribution system. These currents are extremely undesirable, partly because they affect the active rectifier's control and partly because they can cause overheating of the loads that receive power from the distribution system.

"Curtain's going up!" "Curtain's going up!" "A big Broadway opening." "Everybody who's anybody in New York is here tonight." "Everybody but one man." "This man." "Me." "Where are you going?" "Didn't you direct this?" "I just have to..." "One or two things." "Get out of this theatre!" " Is anything wrong with your seat?" " It's facing the stage!" "It's going to be a disaster." "I can't just sit there and watch." "Five seconds and we still haven't got a laugh." "I'm not running away." "I just don't like watching a car crash." "Particularly when it's mine." "It's going to be a catastrophe." "They'll forget their lines." "We won't get out of New York alive." "There's pictures of us in the lobby." "I'll get on a plane." "I should have done when we opened in Des Moines, before we opened, at the dress rehearsal, as soon as the curtain went up." "As soon as the damned phone rang and Dotty came on with the sardines." "Hold on!" "Hold your horses!" "Oh, Lord love a duck!" "Shut up!" "I'm on my way." "It's no good you going on." "I can't open sardines and answer the phone." "I've only got one pair of feet." "Hello?" "Yes, but there's no one here, love..." "No, Mr Brent's not here." "He lives here, yes, but not now because he lives in Spain." "Yes, Philip Brent, who writes plays, only now he writes them in Spain." "She's in Spain, too." "They all are." "Am I in Spain?" "No, I'm not in Spain." "I look after the house for them." "Only I go home at one on Wednesdays, so that's where I am." "No, because I've got a nice plate of sardines to put my feet up with." "And they've got colour here, and it's the Royal...you know, the horse race." "Where's the paper?" "If it's about letting the house, you'll have to ring the house agents." "Squire, Squire, Hackham and..." "Who's the other one?" "No, they're next to the phone in the study." "Squire, Squire, Hackham and..." "Hold on!" "I'll go and look." "As soon as you take the weight off your feet, down it all comes on your head." "And I take the sardines..." "No, I leave the sardines..." "No, I take the sardines." "You leave the sardines and you hang up the phone." "Yes, right." "I hang up the phone." " And you leave the sardines." " I leave the sardines?" "You leave the sardines." "I hang up the phone and I leave the sardines?" "Right!" " We've changed that, have we, dear?" " No, dear." " That's what I've always been doing?" " I wouldn't say that, Dotty." "How about the words?" "Am I getting some of them right?" "Some of them have a very familiar ring." " It's like a slot machine up here." " I know that." "I never know what's going to come out:" "three oranges or two lemons and a banana." "Anyway, it's not midnight yet, and we don't open till tomorrow." " You're holding the receiver." " Right." ""Squire, Squire, Hackham and...hold on!" and noises off." "Squire, Squire, Hackham..." "Hold on!" "Hanging up the phone." "Put your feet up for two minutes and they come running after you." " Hold it!" " This is her afternoon off." " Hold it, Garry." "Dotty!" " We've got the place to ourselves." " Wow!" " Hold it, Brooke." " Dotty!" " Come back?" "Yes, and go out with the newspaper." "The newspaper." "Oh, the newspaper." "Hang up the phone, leave the sardines and go out, with the newspaper." " Here." " Sorry." " Don't worry." "It's just the tech." " It's the dress, Garry." " When was the tech?" " When's the dress?" "We open tomorrow." "We're thinking of it as the tech." " It's the words." " Don't worry about the words." "And that accent." "It's like oranges and lemons." "Your words are fine." "Better than the..." "you know?" "Isn't that right?" " Sorry?" " I mean, OK, he's the..." "But, Dotty, you've been playing this kind of part for, well, I mean..." "Jesus, Dotty, you know?" "Garry and Brooke are off, Dotty is holding the receiver." "We open tomorrow, we've only had two weeks rehearsal, we don't know where we are, but here we are." " Right, Lloyd?" " Beautifully put." "We're playing Des Moines, then Pittsburgh, then God knows where and we're all feeling, you know?" " Aren't you?" " Sorry?" "Garry, you're off." " Sorry, Lloyd, but...you know?" " I know." " Thanks, Lloyd." " So you're off..." "Lloyd, let me just say one thing." "I've known many directors, some geniuses, some bastards, but I've never met one who was so totally..." "I don't know." "Thank you, Garry, I'm very touched." "Now get off the fucking stage." " And Brooke?" " Yes?" " Are you in?" " In?" " Are you there?" " What?" "You're out." "OK, I'll call again." "And on we go." "So, there you are, holding the receiver." "I hold the receiver." "I hang it up." "I leave the sardines." " Always the same story..." " And you take the newspaper." "I take the newspaper." "I leave the sardines." "A weight off your mind, a load off your stomach." " And off I go at last." " Leaving the receiver." "My housekeeper, yes, but..." "And noises off." "Stage!" "This is her afternoon off, so we've got the place to ourselves." " Wow!" " I'll just check." "Hello?" "Anyone at home?" "There's no one here." " What do you think?" " Great!" "It's all yours?" "Just a shack in the woods." "Converted mill, 1 6th century." " Must have cost a bomb." " Ideal for business." "Someone's coming at 4.00." "Arab." "Oil." "I've got to get those files to Basingstoke by 4.00." "We'll just manage to fit it in..." "Do it..." " Right." " We won't chill the champagne." " All these doors!" "Just a handful." "Study, kitchen and housekeeper's flat." "Which one's the...you know?" " Oh, through here." " Fantastic!" "Now I've lost the sardines." " I thought no one was here." " I'm not." "Only it's the Royal..." "The race where they wear those hats." "Who are you?" "From Squire, Squire, Hackham and Dudley." " Which one are you, then?" " I'm Tramplemain." "I thought you were a burglar." "I just dropped in to go into a few things..." "Check some measurements..." "Do one or two odd jobs." "Oh, and I've got a prospective tenant." " What's wrong with this door?" " Her interest is aroused." "That's not the bedroom." "No, that's the downstairs bathroom and WC." " The housekeeper, Mrs Crockett." " Clackett, dear." " She's not here." "It's the Royal." " It's black and white at home." "Don't worry about us." "We'll just inspect the house." " Now I've lost the newspaper." " Sardines!" " Sorry about this." " That's all right." "We don't want the TV." "Sardines!" "I forgot the sardines." "Lloyd!" "These damned sardines!" " We can't go on like this." " Can't go on like what, Garry?" "It's OK for you, but we work with them, don't we?" " Sorry?" " The sardines?" "We're working our asses off and there are four plates of sardines in act one." "Poppy!" "You want something instead of sardines?" " You want mashed banana?" " We don't want mashed banana." " We're changing the sardines." " We're not angry at you, Poppy." "I'm happy with the sardines if you are, hon." " I'm happy if you are." " Garry, what are you saying?" "Here we are, busting our guts up here and, Christ!" " I see." "You got that, Poppy?" " Well..." "Right." "On we go from Dotty's exit." "And Poppy?" "Don't let this happen again." " No." " Sorry.Just getting that straight." " As long as Dotty's happy." " Absolutely." " Do something for me, Dotty." " Anything." "Take the sardines off with you." " I'm sorry about this." " That's all right." "We don't want the TV." "She's been in the family for generations." "Come on." "I've got to be in Basingstoke by 4.00." " Perhaps just some champagne?" " Upstairs." "And bring my files." " Only..." " What?" "Her?" "She has been here for generations." "Sardines, sardines..." "It's not for me to say, but I will say this:" "take the plunge, you'll enjoy it here." "Won't she?" " Yes, well..." " We'll enjoy having you, won't we?" "Terrific!" "Sardines..." "Can't put your feet up on an empty stomach." "She thinks it's great." "She's making us sardines." "She's terrific." " Terrific." " So, which way?" "All right." "Before she comes back with the sardines." " Up here?" "In here?" " Yes, yes, yes." "Another bathroom." "You always try to get me in the bathrooms!" " I mean in here." " Ooh!" "Black sheets!" "That's the linen closet." "This one, this one!" "You're in a real state." "Can't even get the door open." " It's Mrs Clackett's afternoon off." " Hold it!" "Look at it!" "Hold it!" "And God said, "Hold it!"" "And they held it." "And God saw that it was terrible." " The door won't open." " This door won't close." " And God said, "Poppy!"" " You know I'm stupid about doors." " You're doing perfectly." " As long as I didn't break it." "And there was Poppy." "And God said," ""Be fruitful and multiply and fetch Tim to fix the doors."" "I love tech rehearsals!" "She loves tech rehearsals!" "Isn't she, just..." "Where's Dotty?" " Everyone's always so nice." " Belinda's being all, you know?" "Freddy, don't you like an all-night tech?" "Only because you can sit on the furniture." " It's good to see you making jokes." " Oh, was that a joke?" "This is such a nice company to work with." "Broadway in six months!" " Cleveland in three!" " All right, Lloyd?" "I know what God felt like when he sat in the dark, creating the world." " What did he feel like?" " Pleased he'd taken his Valium." "He had six days." "We've only got six hours." "And God said, "Where the hell is Tim?"" "And there was Tim." "And God said, "Let there be doors that open and close."" "Do something?" "I was getting the bananas." "Doors!" "I bet God had a stage manager who understood English, too." " That door won't close." " And the bedroom won't, you know?" " He hasn't been to bed for 48 hours." " Don't worry!" "Only another 24 hours." "Look, he's come down to earth amongst us." "Listen, since we've stopped..." "It took two days to do the set, so we shan't have time for a dress rehearsal." "Don't worry." "Think of the first night as the dress." "If we can just get through tonight for doors and sardines." "It's all about doors and sardines, getting on and off, getting the sardines on and off." "That's farce." "That's the theatre." "That's life." "Oh, God, Lloyd." "You're so deep." "So just keep going." "Bang!" "Bang!" "Bang!" "Bang, you're on!" "Bang, you've said it!" "Bang, you're off!" " Where's Selsdon?" " Oh, God!" " Selsdon!" " Poppy!" " I thought he was out front." " Is Mr Mowbray in his dressing room?" " Would he, during a tech?" " Would who?" " Selsdon." " He wouldn't during a tech." " Half a chance, he would." " What?" " Be fair." " Let's not jump to conclusions." " Get the understudy." "Tim!" " Yes?" "Hurry up with the doors." "You're going on for Selsdon." "He should never have been let out of our sight." "I said that." "He's been good in rehearsals." "In the rehearsal hall, it was all...you know?" "You could see everyone." "Here, there's a front and a back and we've lost him." " He's not in his dressing room." " Bathroom?" "Prop room?" "Paint shop?" "Call the police!" "Doors finished?" "Get the gear on!" " I'm sorry, Dotty, my precious." " No, it's my fault." " I cast him." " I said, "Give him one last chance."" "We did summer stock together when I was a kid." "It's my fault, sweetheart." " This tour is her life savings." " We know that, Garry." "I'm not out to make my fortune." "I just wanted to put something away." "We know." "A little house." "It's not much to ask." " Don't blame yourself." " Sorry?" " Don't cry." " I've got something behind my lens." "It's not Brooke's fault." "He was right there before we started." " Who?" " It's all right." "We know you can't see." "You mean Selsdon?" "I'm not blind." "I can see Selsdon." " Selsdon!" " He's here!" "Standing there like Hamlet's father." " We thought you were...not there." " Where have you been?" " Are you all right?" " Speak to us." " Is it a party?" " Is it a party?" "Is it?" "How killing!" "I thought there was going to be a rehearsal." "I was having a post-prandial snooze so as to be ready for the rehearsal." " Isn't he lovely?" " Now we can see him." " What are we celebrating?" " What are we celebrating?" "Tim, you look strained and anxious." "I can't find the gear." "I've looked in his wardrobe..." "Oh." " Beer?" "In the wardrobe?" " No, Selsdon." "You need a break." "Why don't you sit down and do the payroll?" " I'll do the bananas first." " He's been up for 48 hours." "And don't fall down, Tim." "We may not be insured." " What's next?" " I thought we might try a rehearsal." " I won't, thank you." " You won't?" "No, I'll watch." "Is this the beer in the wardrobe?" " No, he wants to rehearse." " But shouldn't we rehearse?" "I knew you'd think of something." "From Belinda and Freddy's entrance." " What's happened now?" " The police." "They've found an old man in a doorway." " Thank you." " They say he's dirty and smelly." "I thought, "Oh, my God!" because when you get close to Selsdon..." " Poppy!" " No, if you stand anywhere near him, you can't help noticing this very distinctive..." "I tell you, Poppy, once you get it in your nostrils, you never forget it." "Sixty years now, and the smell of the theatre still haunts me." "Bless him!" "Poppy, how did you get a job like this that requires tact?" " You're not somebody's girlfriend?" " Don't worry." "He did not hear." " Not here?" " Yes, there." " Go to sleep." " You're not on for 20 pages." "I might go back to sleep." "I'm not on for 20 pages." "On we go." "Dotty in the kitchen with sardines." "Garry and Brooke on the stairs, Freddy and Belinda waiting outside, time sliding into the past." " Aren't they sweet?" "Garry and Dotty." " You mean, they're...?" " It's supposed to be a secret." " But she's old enough to be...!" " Didn't you know?" " I'm just God." "I don't know anything." " What's happening?" " You tell me." " What are we waiting for?" " Her 1 8th birthday?" "Or maybe just the cue." "Brooke!" ""You can't even get the door open."" " You can't even get the door open." " Door closed, Garry, love!" "You can't even get the door open." "We've got the place entirely to ourselves." "Look at it!" "I can't believe it!" " A perfect place for an assignation!" " Home." "Our secret hideaway." " The last place anyone will look." " It's funny creeping in." "If the Inland Revenue find out, bang goes our claim to be resident abroad, bang goes most of this year's income." "I wonder if Mrs Clackett's aired the beds." " Darling!" " Why not?" "No children, no friends." "We're on our own." "True." "There is something to be said for being a tax exile." "Leave those!" "Shh!" "The Inland Revenue may hear us." "What I did with that first lot of sardines I shall never know." "Mrs Clackett!" " My heart jumped out of my boots!" " So did mine." " I thought you were in Spain." " We are." "We're not here." " The income tax are after you?" " They would be if they knew." "All right, love." "You're not here." "I haven't seen you." " Off to bed, are you?" " Well..." "Nowhere like bed when it all gets on top of you." " You'll want your things." " Yes." " That bed isn't aired." " I'll get a hot-water bottle." " All your letters are in the study." " You forward them, don't you?" " Not the ones from the income tax." " Oh, my God!" "Where are they?" " In the little pigeon-house, dear." " In the pigeon-house?" " I could hear voices." " What sort of voices?" "Hold it!" "What's the trouble?" "You know how stupid I am about moves." "Sorry." "Why do I take the things into the study?" "Shouldn't I leave them?" " No." " I thought it might be more logical." "No." "I know it's late in the day, but..." " No, several minutes before we open." " As long as we're not too rushed." "Why does he carry the bag and groceries into the study?" " They have to be out of the way." " I see that." "And Selsdon needs them in the study." " Where is Selsdon?" "Is he there?" " Selsdon!" "Selsdon!" " Am I on?" " No, no." "I thought I heard my voice." "No." "Go back to sleep." "You're not on for 10 pages." " I see all that." " Oh, no." " But why?" " Why does anyone do anything?" "Why does that other idiot go out with sardines?" " I'm not getting at you." " Of course not." "Jesus, why do I?" " Who knows?" "Who knows?" "The wellsprings of human action are deep and cloudy." "Maybe something happened when you were a small child that made you frightened to let go of groceries." " It could be genetic." " Or...you know." " It could be." " I understand all that..." "I'm telling you I don't know." "I don't think the author knows." "I don't know why the author came into this industry." "Or any of us." "If you could just give me a reason." "All right." "I'll give you a reason." "You carry them into the study because it's slightly after midnight and we're not going to be finished before we open tomorrow." "Correction." "Before we open tonight!" "And on we go, from after Freddy's exit, with groceries." "Lloyd, sweetheart, his wife left him this morning." "Oh." "Freddy?" "I think the point is, you had a great fright when she mentions income tax and you felt insecure and exposed and you wanted something familiar to hold on to." "Thank you, Lloyd." " Bless you!" " And on we merrily go." ""Yes, but I could hear voices."" " Yes, but I could hear voices." " What voices?" " People's!" " No one's here." " I saw the door handle move." " Must you put your tie on to look?" "Mrs Clockett." "She's been here for generations." " Look, she's opened our sardines." " You can't go down like that." " Why not?" " Mrs Crackett." "She's irreplaceable." "Sardines here, sardines there!" "It's like a Sunday school outing." " You still poking around?" " Yes, still poking." "Still around." " In the linen closet?" " No, no!" "Yes, just checking the sheets, going through the inventory." " Mrs Blackett..." " Clackett." "Is there anyone else in the house?" " No one." " I thought I heard voices." " No voices here." " I must have imagined it." " Oh, my God!" " I beg your pardon!" " Oh, my God!" " Why?" "What is it?" "Oh, my God!" "The study door's open." "Oh, my God!" "There's another car outside." "That's not Mr Hackham's, is it?" "Nothing but flapping doors in this house." "Final notice, steps will be taken, foreclosure, proceedings in court..." " A gentleman come about the house." " I'm not here." " He's got a lady quite aroused." " Leave it to the agents." "Shall I let them go all over?" "Anything, but don't tell anyone we're here." "I'll just sit down and..." "Sardines!" "I've forgotten the sardines." "If it wasn't fixed to my shoulders, I'd forget what day it was." "I didn't get this." "I'm in Spain." "If I didn't get it, I didn't open it." "Did I have a dress like this?" "I shouldn't buy anything this tarty." " Did you give me it?" " Never should have touched it!" "Stick it down!" "Never saw it!" "I'll put it in the attic with your other precious gifts." "All right." "Now the study door's open again." "What's going on?" "Knocking!" "Upstairs." "Oh, my God!" "There's something in the linen closet." " Oh, it's you!" " Of course it's me." "You put me in there with the black sheets." " Why did you lock the door?" " Why did you?" " I didn't!" " Someone did." "We can't stand here..." "in your underwear." " OK, I'll take it off." " In here!" "This glue isn't the sort you can never get unstuck, is it?" " Hold it!" " Mrs Clackett's made us sardines." " We have a problem." " Which one this time?" " Left." " It's the left one." " Left one!" " Left one!" " Could be anywhere." " Could have bounced." " Where did you last see it?" " It was in her eye." "She opens her eyes very...don't you?" "I feel I should rush forward." " Careful where you put your feet." " Everyone look under their feet." "No one move their feet!" "Put your feet back where they were!" "Pick up your feet one at a time." "Brooke, is this going to happen during a performance?" " She'll keep going." " Can she see?" " Can she hear without them?" " Sorry?" "Oh, sorry!" " You stepped on his hand!" " Oh, look at Freddy, the poor thing!" " What's the matter?" " Nose bleed." " No one touched him." " Violence makes his nose bleed." "Sorry." "I thought you spoke to me." "Hit the manager with this to finish off theatre in Des Moines." " Anyway, I've found it." " Where?" " In my eye." " Nice going." " Your left eye?" " Yes." "Round the side." " I knew it hadn't gone far." "OK?" " I think so." "Clear the stage." "Walking wounded carry stretcher cases." " All right, Freddy?" " I just have a thing about..." " We understand." " On we bloodily stagger." "Freddy, I'll rephrase that." "On we blindly stumble." "Brooke, I withdraw that." "Anyway..." " Where's Selsdon?" " Selsdon!" "Selsdon!" "She might have dropped it out here." "Good." "Keep looking." "Only another five pages, Selsdon." ""Anyway, we can't stand here...in your underwear." "OK, I'll take it off."" "Darling, this isn't the sort of glue that never comes unstuck, is it?" "Oh, Mrs Clackett's made us sardines." " Now what?" " A hot-water bottle." " I didn't put it there." " I didn't." "Someone in the bathroom filling it." " Is something creepy going on?" " Darling, are you coming to bed?" " What did you say?" " Nothing." "The door handle, the hot-water bottle..." " I've got goose pimples." " Get something on." " Under the covers." " What did I do with the sardines?" "You hear funny things about old houses." "But this one has been modernised." "Nothing creepy could survive..." "What?" "What is it?" "What's happening?" " The sardines!" "They've gone!" " There is something funny going on." "I'm going to put my head under the..." " I put them there." " Bag!" "Mrs Sprockett must have taken them away." " Bag!" " What?" " What is it?" " Bag!" " Bag!" " What do you mean?" " Bag!" "Bag!" " What bag?" "No bag!" "Your bag suddenly here, now gone!" " It's in the bedroom." " Don't go in there!" " The box!" "They've both gone." " My files!" " What's happening?" "Wait here!" " No!" " Get dressed!" " I'm not going in there." "I'll fetch your dress." "Your dress has gone." "Don't panic!" "Don't panic!" "There's some rational explanation." "Mrs Splodgett will tell us." "You wait here." "No, you can't stand here like that." "Wait in the study." "Study, study!" "Roger, there's something in there." "Where are you?" "I know this is going to sound silly, but..." " I'm going to clear out the attic." " I'm glued to a tax demand." " Why don't you put the sardines down?" " I'm stuck to the sardines." "Get that bottle marked "poison"." "It eats through anything." "I've heard of people being stuck with a problem, but this is ridiculous!" "Selsdon!" "You're on, Selsdon!" " We're there." "The moment's arrived." " It's all right." "He's coming." "The arm should have come through." "Ah!" "Here it comes." "No bars, no burglar alarms." "They should be..." "Hold it, Selsdon." "Let's take it again." "Hold it, Selsdon!" "Hold it!" " Lloyd wants you to hold it." " Stop, Selsdon!" "My God!" "Like the band playing on as the Titanic sank." "Stop?" " Thank you." "Selsdon..." " My dad was nearly on the Titanic." "He can hear better than I can." "From your entrance." " It was before the War, so..." " Thank you." "Poppy!" " No." "Stops me sleeping." " Put the glass back." " Come on again?" " Right, only sooner." "Like yesterday." "Freddy!" "Start when Freddy opens the door." "What's the line?" "I've heard of getting stuck with a problem." "Start moving on, "I've heard of getting stuck with a problem."" "I want your arm through the window, right?" " May I make one suggestion?" " What?" "Would it perhaps be better if I came on earlier?" "Only there's a hiatus between Freddy's exit and my entrance." " No, Selsdon, listen." " Yeah?" " I've got it." " What?" " Come on a little earlier." " We're thinking along the same lines." "Am I putting him on or vice versa?" "Freddy, from your exit." "I've heard of getting stuck with a problem, but this is ridiculous." "No bars, no burglar alarms." "They should be prosecuted for incitement." "It makes me weep when I think I used to do banks, bullion vaults." "What am I doing now?" "Breaking into paper bags." "I know they're in Spain because the old turkey in the kitchen said so." "And I saw her go out in her swimming costume." "Get the van loaded." "No rush." "Only got all flaming afternoon." "What have they got to offer?" "One microwave oven." "#50." "Hardly worth lifting it." "Cor!" "Come here!" "Junk, junk, junk!" "Well, yes, if you insist." "Now, where's his desk?" "They all say the same thing:" "it's hard to adjust to retirement." "The prospective tenant wishes to know of any history of the paranormal." "Yes, everything's nice and paranormal here." "Has anything ever dematerialised or flown about?" "No, things move on their own two feet, just like in any house." "I'll tell the prospective tenant." "She's inspecting the study." " There's a man!" " There's no one!" "He's searching for something." " I can't see no one." " This is extraordinary!" "Where's my prospective tenant?" "She's gone!" "Disappeared!" " Oh, my God!" " Now what?" "The sardines!" "Can you see them?" "Yes." "I can see the way they're going." "I'm not letting them out of my hand." "But where is she?" "I can see I'm going to be opening sardines all night." "He said, "It's time to hand over the ammonia bottle to a younger man."" "Where's she gone?" ""I may be 70," I said," ""but I've still got all my wits about me."" " He didn't have an answer to that." " Vicki!" "Vicki!" " Or, if he did, I didn't hear it." " Darling, where are you?" "That stuff doesn't eat through glue, just trousers." "You don't think it eats through...?" "I'd better get these trousers off." "This is an emergency!" "If it eats through anything..." "I can feel it!" "It's eating through everything!" " An evil house!" " The Inland Revenue!" " He's back!" " I'm not here!" " Oh, my God!" " I'm abroad." "I must go." " Stay!" "Speak!" " Only in the presence of my lawyer." "Hold on!" "You're just an intruder!" "An ordinary intruder." "Nice to meet you." "Have a sardine." "No, you're a sex criminal." "You've done something to Vicki." "I'll sort you out." "You've got sardines." "If there's nothing I can offer, I'll be running along." "Come back!" "Hello?" "Police?" "Someone has broken into my house into someone's house, and a young woman is missing." " It's in the garden now, a man!" " She's reappeared." "Are you OK?" " No!" "He almost saw me!" " He almost saw her!" " He's taken our things." " The things are here!" "They're back!" "We're just missing sardines." " Here they are!" " We've found them." "This is the police?" "You want the police here?" "In my underwear?" "Let's say no more." "I thought something terrible had happened." " It has." "I know him." " You know him?" "He's dealt with by our office." "He mustn't see me like this." " The Inland Revenue has standards." " Put something on." " I haven't got anything." " Try the bathroom." "And bring the sardines." "I said, "When have I had to run off in the middle of a job for a piddle?"" "Oh, my God!" "Where is it?" " Stay there till you're dressed." " I can't talk about tax in this!" "I knew I shouldn't have brought the subject up." "Help!" "Where are you?" "Put it on!" "It's a start." "I'll find a bottom." "I'll find a top." "Something." "Someone in there!" "It's him, it's him!" "I'm finding such lovely things." "Remember the biscuit tin you gave me on our first anniversary?" " Who are you?" " Oh, my God!" "I've taken your dress off you." "Where have you been?" "I've been going mad!" "Look at the state I'm in!" "I was trying to explain about the Inland Revenue and my fingers got stuck." "Don't wave it in my face." "I'm trying to find something." " Pair of gold taps." "Oh, God!" " Who are you?" " Doing the taps." " Income tax?" "That's right." "In come the new taps, out go the old." "Tax inspectors everywhere!" "Oh, my God!" "Boxes flying about!" "There is something funny going on." "Are you dressed yet?" "I've got the dress stuck to my head now." " A man!" " Doing the taps." " Attacks?" "On women?" " I'll do the taps on the bath first." "Sex criminals everywhere." "Where is Vicki?" "Vicki!" "I'm off." "Tax on women?" "They'll tax anything these days." "You're in trouble, you see?" " WC?" "I'll fix it." " Vicki!" "Sheikh!" "I thought you were coming at 4.00!" "And this is your charming wife?" "You want to see over the house now?" "Since you're upstairs..." " Him and his floozy!" " Let's start downstairs." "Who are you?" "I don't know who she is." "No connection with the house." " This good lady with the sardines..." " This time, I'm eating them." "...is fully occupied." "The toilet facilities..." " Mrs Clackett, who are these people?" "Just Arab sheikhs." "I'm sorry." "This is the downstairs bathroom." " Upstairs, we have..." " Your ballcocks have gone." " We have him." " Irish linen sheets off my own bed!" " In the study, however..." " Give me that sheet!" "There she stands in her smalls for all the world to see." " It's my little girl." " Dad!" " My little Vicki that ran away." " Would you believe it?" " What are you doing here?" " What about you?" "I'm taking our files on tax evasion to Basingstoke." "Where's my other sheet?" "Ah, a house of heavenly peace!" "I rent it!" " You!" " Is it?" "I still have my trousers round my ankles." "I have no dresser." "Get Tim to help you." "Tim!" "Where's Tim?" "Come on, Tim!" " What?" " Oh, you're acting." " I must have dozed off." " Never mind." " Do something?" " No, we'll struggle through." "Tim sleeps while we run around with our trousers round our ankles." "OK, Freddy, from your entrance with trousers round ankles." ""So, where's my other sheet?" Some other problem, Freddy?" " Since we're stopped..." " Why did I ask?" "I'm stupid about plot." "Could I ask another dumb question?" "All of my studies in world drama lie at your disposal." "Why is the sheikh Philip's double?" "He comes in and we think he's, you know..." " That's the joke." " I see that." " The plot depends on it." " But it is a coincidence, isn't it?" "It is kind of a coincidence, Freddy, yes." "Until you reflect that there was an earlier draft of the play." "In this, it's clear that Philip's father, as a young man, travelled in the Middle East." " I see." " You see?" " Interesting." " Yes." " Will the audience get it?" " You show them." " That's what acting's about." " Thank you, Lloyd." "So, from your entrance, Freddy." "What's going to be left of this show when I'm back in New York and you're up there on your own?" "So, where's my other sheet?" "Ah!" "A house of heavenly peace!" "I rent it!" " You!" " Is it?" " Who else?" " You ask to view this house when you're a trouserless tramp!" " You took the clean sheets!" " You snatched my nightdress." "You tossed me aside like a broken china doll." "I won't ask what you were up to with my girl, but I'll tell you one thing." " Brooke!" " Sorry." "Your line!" "We're two lines from the end of the act." " I don't understand." " Tell her." " "What's that, Dad?"" " But I don't understand." "I say, "I'll tell you something." You say, "What's that, Dad?"" "I don't understand why the sheikh looks like Philip." "Poppy!" "Bring the book!" "Is it "I don't understand why the sheikh looks like Philip"?" "Can we consult the author's text?" ""What's that, Dad?"" "Right." "That's the line." "We know you've worked in places where you make it up as you go along, but we don't want that here, not when there's a polished line already." "Not at 1 a.m., not two lines from the end of act one." "Not when we're about to get a coffee break." "We merely want to hear the line "What's that, Dad?" That's all." "Nothing else!" "I'm not being unreasonable, am I?" "Exit?" "Does it say "exit"?" "Oh, my God." "She's going to wash away her lenses." " Oh, dear." " A little heavy." "I thought it was going to be Poppy." " This is all my fault." " Why Brooke?" " It was sweet." " Sweet?" " A lovers' quarrel." " You mean Lloyd and Brooke?" "Where do you think they've been all weekend?" "That's why he didn't realise the set was wrong." " Shh!" "Here they come." " All forgotten." "I was irresistible." " I'm going to throw up." " What?" " Oh, no!" " Oh, God!" " Poppy?" " You pig!" " You mean...?" " I didn't know that." " I'm going to faint." " Head between your knees." " Nothing she didn't know!" " Two weeks' rehearsal." "That's all!" " What's next?" " Most exciting." " Is she all right?" " She will be." "Something she ate." " This one's a bit, you know?" " I'm feeling a bit, you know, myself." " I need that coffee break." " You're certainly overdoing it." "Can we just have the last line of the act?" "Me?" "Last line?" "Right." "Well, I'll tell you one thing, Vicki." "What's that, Dad?" "When all around is uncertainty, there's nothing like a good old-fashioned plate of sardines." " And curtain!" " Oh." "All right." "Let's reset for night, act two." "In fact, they loved it in Des Moines." "At the end of act two, they laughed." "What's this?" "There's only one thing missing:" "a plate of sardines." "Yeah." "They clapped and clapped." "In Des Moines." "Well, they clapped." "Even Selsdon heard them." "But then there was Decatur, Illinois, then there was Cairo, Missouri, and Paducah, Kentucky." "I wasn't there for the difficulties in Decatur or the problems in Paducah, but I couldn't always hold their hands." "How could I be in Decatur and Paducah when I was doing Hamlet in New York?" "I caught up with the show in Miami Beach." "I was right in there with them when they did that famous matinée." " Sir, your ticket?" " I'm the director." "Don't tell anyone." "Act one places." "Your calls, Miss Otley, Miss Ashton," "Mr Lejeune, Mr Dallas, Miss Blair." "Act one places, please." "Do you think we'll get act one places?" "She'll pull herself together now we've called places." "Won't she?" " Will she?" " You know Dotty." "We're only at Miami Beach." "What will it be like by Cleveland?" " If only she'd speak." " Or unlock the door." " If she won't go on..." " Won't." "If she won't..." "Of course she will, but if she doesn't..." " She must!" " She will." "But if she didn't..." " I'd have five minutes to change." "Four." " If only she'd say something." "I'll try again." "Helps take your mind off your own problems." " Has she gone?" " Lloyd!" "I didn't know you were coming to Miami Beach." " I wasn't." " Good you're here!" "Dotty and Garry..." "No one must know I'm in." "Hide this somewhere." "Right..." "They've had a fight." "There's a flower stall round the back." "Buy some expensive-looking flowers." " Right." "Dotty's locked herself in." " Don't let Poppy see." "She won't speak to anyone." "The matinée finishes by five." "I want two hours alone with Brooke in her dressing room, then I'm back to New York." " There may not be a show." " She's walked out already?" " She's locked in and won't speak." " You've called places?" " Yes." " I can't do it in five minutes." " She's broken up with Garry before." " Brooke?" "Not Brooke, Dotty." "There was the one the week before last in Pittsburgh." "She went out with a reporter, but Garry threatened to kill him." "Don't worry." "Dotty's got money in the show." "But last night, Garry wakes me at 2 a.m. asking where Dotty is." "Let me tell you about my life." "Hamlet's ghost complains every evening that Polonius is sucking sourballs through his speeches." "Claudius is off doing a soap and Gertrude is off doing a commercial." "Hamlet himself has come down with a psychological problem." "Then Brooke rings to say she's got a doctor's certificate for exhaustion." "I can't find a new Vicki." "I have just one afternoon while Hamlet sees his shrink to cure Brooke of her exhaustion with some whisky, a few flowers - you've got the money - and a certain fading bedside manner." "I haven't come to hear others' problems, but to be taken out of myself and not put back." " But..." " Done the front-of-house calls?" " Front-of-house calls." " Don't let Poppy see those flowers!" "Ladies and gentlemen, take your seats." "The curtain will rise in three minutes." " We're going to be so late." " No luck?" "I haven't even started the front-of-house calls." " Money." "Is that for me?" " No, no!" "Whisky." "Where did you find that?" "Not up here?" "He's hiding it up here!" "I'll put it downstairs where he can't find it." " No?" " You know Dotty." "Freddy's trying." " God!" " He's hiding them here." "No?" " No." " You didn't try for long." " He's hiding them here now." " Garry came rushing out." "I couldn't understand him." "I am stupid." "But I think he wanted to kill me." " You poor thing!" " I left him alone." "Is he all right?" " Anything but!" " He's going on?" "Going on?" "Garry?" "Of course Garry's going on!" "If you have to go on for Garry, Poppy can't go on for Dotty." " Oh, God!" " Money!" "For us?" "No..." "Oh, my God!" "Dotty's so up and down." "She was perfectly all right last night." " Last night?" " She took me to a pub she knows." "She was with you?" "You were with her?" " She was very sympathetic." " She's not sinking her teeth in!" "No." "She came up for coffee and told me her troubles." "We talked till 3 a.m. I don't know what room service thought." "And another thing." "Where's Selsdon?" " It turns out Freddy..." "Selsdon?" " Not in his dressing room." " Front-of-house calls!" " Do them." "I'll get Selsdon." " What should I do?" " Nothing." "You've done enough already." "Ladies and gentlemen, take your seats." "The curtain will rise in three minutes." " He wants to kill someone?" " Selsdon?" " Garry." " We've lost Selsdon." " Oh, my God!" " Flowers!" "They're just, you know." "Tim, that's sweet of you." "Isn't that sweet?" " Charming." " I'll look in the bar." "Hold these." "I'll take those." "Front-of-house calls!" "Hold these." " Poppy's done them." " Did she give them two minutes?" "Ladies and gentlemen, take your seats." "The curtain will rise in one minute." " I think she said three minutes." " Did she?" " I think so." " Hold these." "Ladies and gentlemen, take your seats." "The curtain will rise in two minutes." " Any luck?" " No, but I found this." "Hidden behind the fire extinguisher." " I'll take it." " Put it somewhere out of sight." " He's...not in the bar." " Have you checked the green room?" " Yes." " I'll check again." "Take your seats." "The curtain will rise in two minutes." " Tim's said that." " He has?" "Take your seats." "The curtain will rise in one minute." " What the fuck is going on?" " Lloyd!" " I didn't know you were here." " I'm in New York." "But I can't sit out there and listen to that." " We're having big dramas back here." " And out there." "This is a matinée." "Senior citizens!" "Curtain up in three minutes, we all start for the gents." " One minute, we run out again." " I've got to talk to you." "Just tell me one thing." "Is Brooke going on?" " Brooke?" "You're going on, aren't you?" " Sorry?" " All right?" " All right?" " She sounds like her usual self." " Lloyd!" " What's this?" " I was lying on the floor and..." " On the floor?" " For relaxation." " I saw it behind the radiator." " Oh, my God!" " I'll hide it." " In Brooke's dressing room." " What's this?" " Oh, yes." "Sorry." " Tim bought them for me." " You?" " We've got to talk." " I've heard all I want." " What about Dotty?" " No!" " Selsdon?" " This show is beyond my help." "Just do it." "I'll sit out there with a bag of sweets and enjoy it." "One minute was the last call, if you remember." " Is she all right?" " It's her way of relaxing." "I couldn't concentrate back there with the shouting." " It's her breathing." " You don't have to go on." "It's only a matinée." "I'm sure Poppy would love to do it." " I'll see what's up with Dotty." " Freddy, my darling!" " What?" " Where's Tim?" "Where have you been?" "We looked for you everywhere." " Everywhere." "There's no sign of him." " He's been looking for you." "Great shindig going on back there." "I thought Tim should know." " He's heard." " Everything!" "He really went for her!" ""I've seen the way you're looking at Freddy," he says." " Oh, God!" " Me?" " Yes, darling." " Are you sure?" "Maybe Teddy." "Teddy or Freddy." "Anyway..." " They're coming!" " I knew they wouldn't." " And you're here?" " Yes." "Every word." "Ladies and gentlemen, take your seats." "The performance is about to begin." " They're coming!" " We found Selsdon." " How did you get here?" " How?" "She took it amiss." "Ladies and gentlemen, take your seats..." " I've done it!" "I've done it!" " Oh." " Lloyd will choke on his sweets!" " Garry, darling!" "Trying to give a fellow a leg up, or a leg over..." " Oh, there he is." " Are you all right?" " What did he say?" " Nothing." "Very sensible." ""You've got your claws into Freddy," he said." " Dotty!" " Is she all right?" " She's fine." " All right, everyone?" " Teddy or Freddy." " Hush, dear!" "Places, please." "Garry, Dotty, I won't make a big speech, but we've got to go and perform." " And, well..." " We can't do it in silence." "We have to speak to each other." " What's the house like?" " That's the spirit!" " Well done!" " Good for a matinée." "There's a crowd at the back of the orchestra." "Come on." "Some of those seniors haven't got long." "Quiet, then, please." "Pre-set, please." "Quiet on stage, stand by, curtain up, act one." " Now what?" " We're going up." "We've been sitting out there an hour." " I was just saying a few words." " You need a brain transplant." "Wrong moment." "I see that." " Any other thoughts to communicate?" " Not right now." "Later." " You bought these flowers for Poppy?" " No, well, yes." " And none for..." "B?" " Well, no." " Have you heard of jealous rage?" " Yes." "Then take $ 1 0 of your money and buy some flowers for me!" "You two can have Freddy's old brain." "You can have half each!" " Oh, dear!" " Don't cry, hon." "Get the old bus on the road." "Act one: music, summer noises, house lights, go!" "Coming!" "Oh, Lord love a duck!" "I'm coming!" "Shut up!" "I'm coming!" "Hold on!" "I can't open sardines and answer the phone." "I've only got one pair of hands." "Hello?" "Yes, but there's no one here." "No, Mr Brent's not here..." "This is my housekeeper's afternoon off," " so we've got the place to ourselves." " Wow!" "I'll just check." "Hello!" "Anyone at home?" "There's no one." "What do you think?" " All these doors!" " Just a handful.:" "study, kitchen and housekeeper's flat." "Terrific!" "Which one's the, you know...?" " Oh, through here." " Fantastic!" "Now I've lost the sar..." "I've lost the sardines!" "Sorry." "I thought there was no one here..." "Sardines!" "Sardines!" "It's not for me to say, of course..." " Up here?" "In here?" " Yes, yes, yes!" " It's another bathroom." " No, no, no!" " Ooh!" "Black sheets!" " It's the linen closet." " This one, this one." " You're in a state." "You can't even get the door open." "It's Mrs Clackett's afternoon off." "We've got the place to ourselves." " Look at it!" " Do you like it?" " I can't believe it!" " A perfect place for an assignation..." "Sardines here, sardines there!" "It's like a Sunday school outing." "Oh, my God!" " I beg your pardon?" " Oh, my God!" " Why, what is it?" " My God, the study door's open..." "Nothing...but...flapping doors...in...this...house..." "Give it to me!" "Darling, I never had a..." "I never had a dress..." " Or, rather, flowers like these?" " Oh, didn't you?" "I shouldn't buy anything as tarty..." "Oh, God!" "All right!" "Now the study door's open again." "What's going on?" "Knocking!" "Knocking?" "Knocking." "Upstairs!" "There's something in the linen closet!" "Oh, it's you." "Is it you?" "I mean, hidden under all the sheets and towels in here?" "I can't, you know, just stand here indefinitely." "Of course it's me." "You put me here with all the black sheets." "Darling, why did you lock the door?" "I didn't." "Why did you lock the door?" "I didn't." "Anyway, we can't stand here like this." " Like what?" " In your underwear." " OK, I'll take it off." " You!" "On!" "Darling, this isn't the glue you can never get unstuck, is it?" "Oh, look!" "Mrs Clackett's made us some sardines." "A hot-water bottle?" "I didn't put it there." "I didn't..." "I mean, I'm standing here with this hot-water bottle in my hand!" "Of course it's me!" "You put me in here with all the black sheets." "Someone in the bathroom?" "What?" "Don't panic!" "Don't panic!" " Why did you lock the door?" " Don't panic!" "Don't panic!" "There's a rational explanation..." " You wait in the study." "Study, study!" " Oh!" "There's something in there..." "I've heard of getting stuck with a problem, but this is ridiculous." "I've heard of getting stuck with a problem but this is ridiculous!" "No bars, no burglar alarms." "They should be prosecuted for incitement." "Lloyd." "Ooh, yes..." "A line?" "A prompt?" " Get the van loaded." " What?" "Get the van loaded!" "Right..." "Get the van loaded." " There's a man in there!" " No one's there." " Look!" "He's searching for something." " No one..." "Oh, no!" "Oh, dear!" "There's something even in this..." "You're a sex criminal!" "I'm going to come and sort you..." "You've got sardines?" "If there's nothing I can offer you..." "Are you all right?" "You killed him!" " Police!" " I think I'll be running along." "Come back!" "Hello?" "Police?" "Someone has broken into my house..." "And a young woman is missing." "And a young woman is missing." "And a young woman is missing!" "It's in the garden now, and it's a..." "Tim!" "No sheikh yet?" "I thought he was coming at four." "I mean, it's nearly four now, well, it's after three." "I've been standing here for ever." "Lloyd, listen!" "I've got to talk to you now." " Now is..." " Not a good time." "I know." "It never is." " You're right!" "Freddy's quick change!" " Christ, his change!" "Those thieving devils!" "Give me that sheet!" "There she stands, in her sheet that won't come off so no one can see her." "My little girl!" "As far as I could see." " Dad!" " Surely that was my little Vicki..." "So, where's my...?" "So, where's my other sheet?" "Ah!" "A house of heavenly peace!" "I rent it!" "I've tried calling you." "I know you're in rehearsals, but you're never there." "No!" "I'm not going to be put off!" "I know you'll be seeing her." "She's being difficult, isn't she?" "Then you'll be on the next train to New York." "I bet there's somebody else in Hamlet, but you can't just walk away." "I'm sorry, but you've got to hear because I'm pregnant." "And curtain!" "If you thought Miami Beach was as bad as it could get, you were mistaken." "Things got a lot worse backstage by the time we got to Spartanburg." "After Spartanburg was Lynchburg." "After Lynchburg, Parkersburg and Petersburg." "After Parkersburg and Petersburg, there was Peter-Piper-picked-a-peck- of-pickled-peppers-burg." "But nothing could have prepared us for the final horror." "Cleveland." "I'm something you'll never be, and that's a star!" "Your cockney accent sounds like Dolly Parton." "Stay away from Freddy!" "He never did anything to you!" " Garry was using you!" " Quiet!" "Hold on!" "I'm coming!" "Hold your horses." "I'll be right there." "Hold on!" "I can't get sardines off the floor and answer the phone." "I've only got one leg." "Hello?" "Hello?" "Yes, but there's no one here, love." "Mr Brent's not here now." "He lives in Spain." "Yes, he writes plays, though why he wants to get mixed up in plays, God knows." "He'd be safer in a snake pit." "No, she's in Spain, too." "They're all in Spain." "Am I in Spain?" "No, I'm not in Spain!" "I'm in agony, that's where I am!" "We haven't been on the road three months and she's trying to kill me!" "I'm standing with a plate of sardines and she kicks me in the..." "Where the hell are they?" "If it's to do with renting..." " Selsdon!" " Selsdon?" " I can't find him." " I'll find him." "No, they're next to the study in the phone." "Squire, Squire, Hackham and..." "Hold on!" "I'm going to do something wrong here." "Oh, yes!" "Always the same." "As soon as you've got too much on your plate, you go putting your foot in it." "Oh, speak of the Devil." "They'll all go putting their foot in it now, won't they?" "Well..." "I'll just put that down." "That'll keep them out of harm's way." "What I'm holding now I don't know." "And off I go at last." "My housekeeper, yes, but this is her afternoon off." "So we've got the place entirely to ourselves." " Wow!" " I'll just check." "Hello?" "Anyone at home?" "No, there's no one here." " So, what do you think?" " Great!" "Is it all yours?" "Just a little shack in the woods." "Converted mill, sixteenth century." "Well, one has to have somewhere to entertain business associates." "Someone on the phone now, by the look of it." "Probably this Arab, saying he's coming at four." "I'll have a word with him." "I've got to get those files to Basingstoke by four." "We'll just manage to pick it in, to fit it up, I mean..." " Right, then." " We won't pull the champagne." "All these doors!" "Only a handful: study, kitchen and the flat for the...receiver." " Terrific!" "Which one's the..." " What?" " You know." " Oh, yes, through here." " It's, umm...through here." " Fantastic." " I've come for my sardines." " I thought no one was here." " I'm not." " I'm from the agents." "Lost the phone now." "Never lost the phone before." " I'm Tramplemain." " I'll put it here in case it's wanted." "Thanks." "I dropped in to check some measurements, do some odd jobs." " The plate's gone." " I've got a prospective tenant." " What's wrong with this door?" " Her interest is aroused." " That's not the bedroom." " No, no." "That's the bathroom." "This is the housekeeper, Mrs Crockett." " Sardines!" "Sardines!" " She's not really here." " You're standing on them." " It's the Royal." " You shouldn't have!" " Don't worry about us." " I need them!" " We'll inspect the house." " I'll have to wash the floor." " Sorry about this." " That's all right." "We don't want a TV." " A TV?" "Right." "She didn't explain about wanting to watch the Royal because of this thing with the..." "In case somebody's looking at this and thinking, "My God!"" " I've got to be gone by four." "Just getting that straight." " We'll take it up." "Bring my files." " Where are we?" " What?" "Her?" " Her?" "OK, her!" "She's been in the family for generations." "I'll wash the floor with this and they'll be out of your way." " Look what I've got." " Great!" " Like a battlefield back there." " Terrific!" "I'll put this here." "Then, if he wants it, he won't know where to find it." "You'll have to do the sardines because I've got to do more sardines." "See?" "She's even making us sardines." " What do you think?" " She's terrific." " Do you want...?" " Which way?" "I don't know." "Just wrap them in the, you know..." " Up here?" " I'll do the..." "In here?" "It's another bathroom." " Box!" "Bag!" " Trying to get me in the bathroom!" " Bag!" "Box!" " Oh!" "Black sheets!" " Box, box, bag, bag!" " You're in a real state." "If we haven't got the, you know, upstairs, I mean..." "You can't even open the door." "This is Mrs Clackett's afternoon off." " We've got the place to ourselves." " Look at it!" "I can't believe it." " Perfect for an assignation." " Home!" "The phone was in the garden." " I'll put it back." " Someone's bound to want it." " Put it on the table." " The wire's caught." "Look!" "It's caught round the downstairs bathroom." " I've disentangled it." " I climbed in the window and..." "Oh." " Anyway, our secret hideaway." " The last place anyone will..." "Look for us?" "Yes." "It's funny creeping in like this." " What?" " You're thinking it's damned serious." " Sorry, yes." "Damned serious." " About the Inland Revenue." "Absolutely." "To cut a long story short, I think I'll wash up and go to bed." "But we must talk about the Inland Revenue." "If they find out we're in the country, bang goes our claim to be resident abroad." "Leave those!" " Downstairs!" "Not upstairs!" " The Inland Revenue may hear!" "One moment they're kicking you, the next they expect more sardines." " Mrs Newspaper!" " My heart jumped right out of itself!" " We thought you'd gone." " I thought you were in Sardinia." " We are!" " You haven't seen us." "They brought me a present." "The taxman is after us." " I know who thought of this." " We're off to bed." " Leaves them on the sofa!" " Is it aired?" " I've got a surprise for you!" " No?" "I'll get a hot-water bottle." " No!" "No!" " Let me at her!" " Oh, dear!" " She's left you on your own?" "Must you talk to yourself?" "Has she told you about your letters?" " What?" " The tax letters are in the study." " I say that!" " In the pigeon-house." " The pigeon-house?" " The pigeon-hole!" "Anybody would think you were married." " But I could hear voices." " Voices?" "What sort of voices?" " Box voices..." "People's boxes." " There's no one here." "I saw the door handle move, and these bags, I mean..." "I'm not sure they were, you know, when we went in." "Do you have to put your tie on?" "If someone left them outside," "I mean, they obviously wish them to be downstairs in the..." " Mrs Clockett?" " Could be." "Carrying various things." "Who knows?" "You can't go like that." "Mrs Crackett." "She's irreplaceable." "Well, at least I thanked her properly for the sardines." " Still poking around, are you?" " Yes, still poking." "Still pulling." "Lucky I can't see far with this leg." "Just trying all the doors, checking all the door handles." " Mrs Blackett." " Clackett." " Is there anyone else in the house?" " No one." "I heard boxes..." "I found these voices." " No." " I must have imagined it." "Oh, my God!" "I beg your pardon?" "Oh, my God!" " What is it?" " Oh, my God!" "The study door's open." "They'll need these inside the..." "So I'll just put them outside the..." "Then they can, you know?" "Nothing but flapping doors in this...handle." "Final notice, steps will be taken, foreclosure, proceedings in court..." " Oh, my God!" "Who are you?" " I'm Philip." "You're Philip?" "What happened to you?" "There were sardines on the floor and I slipped." "She's killed him!" "She's killed you!" "No, he's just a bit shaken." "I'll be all right in a minute." "You weren't going to tell me a gentleman had come about the house?" "What?" " A gentleman about the house?" " A gentleman come about the house." " Don't tell me." "I'm not here." " You haven't hurt himself?" "Leave everything to Squire, Squire, Hackham and Poppy." "All right, I'll just sit down and turn on the sardines." "I've forgotten the sardines." "No, I haven't." "I remembered the sardines." "Well, what a surprise!" "I'll just go and fix some more sardines to celebrate." "I didn't get this." "I'm not here." "I'm in Spain." "But if I didn't get it, I didn't open it." "Darling..." " I never had a handle like this." " Didn't you?" "I shouldn't buy anything this brassy." "Or did you give it to me?" " I should never have touched it." " It's lovely." "Stick it down, put it back." "Never saw it." "I'll put it in the attic in case anyone else wants to have a try." "All right." "Now the study door's..." "closed again." "What's going on?" "Knocking!" "Upstairs!" "There's something in the linen..." "Oh, my God!" "Listen, I can't." "I can't because the handle seems to have..." "You'll just have to..." "Come on!" "Whatever's in there..." "Can you hear me, darling?" "There's no need to keep banging." "It won't, you know?" "There's no place to..." "Listen, climb round into the..." "Squeeze through the, you know?" "Shin down the..." "There must be some way." "For God's sake!" "Final notice, steps will be taken, foreclosure, proceedings in court..." " It's you!" " Of course!" "You put me in there with the black sheets." "I put you in there, but you squeezed through." " Why did you lock the door?" " I couldn't." "It's come off." " Someone locked the door." " Sorry." "You can't stand here like that." "I mean, with people going in and out." " OK, I'll take it off." " In here!" "Final notice, steps will be taken, foreclosure, proceedings in court..." " Now what?" " A hot-water box!" "I didn't put it there." "Sorry." "Is someone in the bathroom filling first-aid bottles?" "Darling!" "Darling, are you coming to bed or aren't you?" " What did you say?" " Nothing." "The door handle, the first-water box." " I've got goose pimples." " Get something on." " Under the covers!" " What about the sardines?" "Wait!" "You hear funny things about old houses." "But this one has been modernised." "Nothing creepy could survive..." "What?" "What is it?" "What's happening?" "The sardines!" "They've gone!" "No, they haven't!" "They're here!" "Oh!" "Well!" "My God!" "You put a plate of sardines down for two minutes and the last thing you expect to find, these days..." "You do not expect to find a plate of..." "That's weird." "I'm going to get into bed and put my head under the..." "Because there they are, exactly where I..." " Bag!" " I suppose Mrs Sprockett must have..." " I mean,Jesus!" "What is going on?" " Bag!" " Bag?" " Bag!" "Bag!" " What do you mean?" "Sardines!" " Bag!" "Bag!" "Bag!" " Sardines!" "Sardines!" " Bag!" "Bag!" "Bag!" " Bag!" "Bag!" "Bag!" " Bag?" "What bag?" " No bag!" " No bag?" " Your bag suddenly here, now gone!" " It's in the bedroom." "I put it there." "I'll put it in the bedroom." "Don't go in there!" "The box!" "They've both not gone!" "Where's Mrs Sprockett?" "Wait in the bedroom!" " No!" " Get dressed, then!" " I'm not going in there." " I'll fetch your dress out here." "Your dress has gone." "Don't panic!" "Don't panic!" "There's a rational explanation for this." " This is going to sound silly, but..." " I'm going to clear out the attic." " Are you all right?" " Oh, my God!" " She's killed him." " He's stunned." " Oh, dear." " She put sardines on the stairs." " Don't panic!" " He's all right!" " She'll get you next time." " There's a rational explanation." " I'll fetch Mrs Splodgett." " You have." "I'm here." " She'll tell us what's happening." " No, she won't." "She doesn't know." " I'll tell you." " A man's there." "No, he's not there." "He's here, and so am I." "No, no." "There's no one in the house." "No, I know this is a surprise." "It's quite a shock finding a man lying at the bottom of the stairs." "But now we've all met, we'll just have to introduce ourselves." "This is my husband." "He hates surprises." "So, why don't you get that stuff in the loo that eats through anything?" "Eats through anything." "Right." "Thank you." "I've heard of getting stuck with a problem, but this is ridiculous." "No bars, no burglar alarms." "They should be prosecuted for incitement." " Come in and join the party, honey." " A burglar!" "This is most exciting." "It's my fault." "I say, "I've heard of getting stuck with a problem,"" "and open this door..." "No bars, no burglar alarms." "They should be prosecuted for incitement." "Oh, dear." "I've done it again." " It makes me want to weep." " I know." "It's getting like a funeral." " When I think I used to do banks." "Just keep going!" "When I remember I used to do bullion vaults." "What am I doing now?" "Breaking into paper bags." " Keep going." " I thought the coast was clear." " I saw him go through." " We'll think of something." "I was listening." "What's it he says?" "I've heard of getting stuck with a problem, but this is ridiculous." "No bars, no burglar alarms." "They should be prosecuted for incitement." " Oh, no!" " They always come in threes." "When I think I used to do banks." "When I remember I used to do bullion vaults." "Hold on!" "We know this man!" "He's not a burglar, he's our social worker!" "He's that nice man who comes and tells us what to do." " I've been working on Hamlet." " You think he needs it more?" " He's playing the burglar now?" " No." " Let me think..." "Fetch the sardines." " I've fetched the sardines." " You have?" " She's fetched the sardines." " Get the tax demand." " He has." "All right." "I suggest, I suggest..." " What's he saying?" " He's saying, "Ring the police!"" "Ring the police!" "It's for you." " No phone!" " Get the phone." " Here's the phone." " We've found the phone!" " Pick it up!" " Pick it up!" "It's the police." "I'll just tell them a young woman is missing." "It's in the garden now, and it's a man!" "Oh, it's her!" "We forgot all about her." " No, he almost saw me." " What do you think of that?" "I've got to get the 8.40 to New York." "Ah!" "House of heavenly peace." "I rent it." " Oh, it's the other one!" " In her wedding dress." "Yes, yes!" "It's their wedding day." "What a happy ending." "To the first act." "Of their new life together." "They just want to be alone, if only someone would pull the shades." " Come in?" " It's the bride's mother." " Go out?" " Pull the shades!" "Last line!" " I'll tell you one thing, Vicki." " What's that, Dad?" "When all around is uncertainty, there's nothing like a good, old-fashioned plate of...curtain!" "What's this?" "Only one thing we're missing now:" "a plate of..." "Sardines!" "Bravo!" "Yes!" "I did it!" "We did it!" "My wonderful cast!" "I knew we'd make it." "Never doubted it for a moment." "Let me tell you, you are a wonderful stage-door keeper." "Look at these two." "Don't they make a wonderful couple?" "Tim's wonderful, she's wonderful, whoever she is." "Poppy's wonderful, the baby's going to be wonderful." "We're all wonderful." "I'm wonderful." "That's all it takes for success.:" "wonderful actors, teamwork, dedication, six months on the road, professionalism." "Plus something else - I think some kind of miracle." "Don't forget the miracle." "And by the way, another funny thing happened on the road." "I didn't tell you about this one." "You don't believe this?" "Neither do I." "Never seen anything like it." "But what did Shakespeare say?" "There's no business like show business" "Like no business I know"

Family visitation in greek intensive care units: nurses' perspective. Policies of flexible and open visiting in intensive care units benefit both patients and patients' families. In Greek intensive care units, gaps exist between evidence and practice for family visitation, resulting in restricted visiting policies. To explore the beliefs of nurses in Greek intensive care units about the effects of visiting on patients, patients' families, and unit staff and nurses' attitudes toward visiting policies. A descriptive correlational survey was conducted in 6 public hospitals in Athens, Greece, with a sample of 143 critical care nurses. Data were collected via an anonymous questionnaire consisting of 3 validated scales to assess the nurses' beliefs about and attitudes toward visitation. Generally, nurses were resistant to family visiting and open visiting, and most (94.4%) did not want an open policy in their unit. Nurses think that open visiting policies are supportive for patients and patients families, but the overall effects of visiting depend on both the nurse and the patient (91.6%). Nurses reported that open visiting created increased physical and psychological burdens for them (87.5%) and hampered nursing care (75.5%). Years of work experience, staffing level, and number of night shifts worked by nurses per 15 days were factors predictive of nurses' attitudes toward and beliefs about family visitation. Nurses' beliefs about and attitudes toward visitation are important factors in the implementation of more flexible visiting policies in Greek intensive care units. Well-staffed units with experienced nurses and fewer shifts per week may affect nurses' negative attitude toward open visitation.

It is well known in the art to use building panels to make wall or partition surface assemblies on structural building frames. There are various requirements for such building panel assemblies. In particular the panels must be capable of quick, simple and reliable assembly. This will ensure that wall surfaces can be rapidly built, with minimal risk of damage to the wall panels during assembly. In the case of an exterior wall, the joints should protect the building from the ingress of wind, moisture, and other environmental factors. In the case of an interior partition, the joints should be draftproof. The problems encountered by existing panels are numerous. As the concept of panel modularity evolved, panels became larger in the interests of faster assembly time since obviously fewer large panels would be needed to complete a wall surface when compared to, for example, smaller panels or even bricks. Large panels present various drawbacks, some of which are their increased weight and bulk, making it difficult to manoeuvre, position and attach the large panels to a building structure. Add to this the difficulty in sealing the edges of adjacent panels, such difficulty being accentuated the taller or more inaccessible the building structure becomes. Furthermore, large panels, once installed, are not removable from the building structure without damages to the panels and/or the structure, thus preventing the re-installation of the panels on another structure or simply on the same building structure after relocation thereof. Attempts have been made previously to seal the edges of adjacent panels with rubber sill garage doors sealing or windows rubber hoses sealing system but among the consistent drawbacks has been the frequent damage to sealing surfaces while the panels are handled, and during the building assembly activity. The damage to the sealing surfaces is often difficult to detect and repair during construction, resulting in drafty, leaky buildings that require repair as soon as they are placed in service. Accordingly, there is a need for an improved building panel with modular, self-aligning, quick-assembly interfaces providing sealing and weatherproofing.

An ink-jet printer includes a pen in which small droplets of ink are formed and ejected from the printer pen toward a printing medium. Such pens include printheads with orifice plates with several very small nozzles through which the ink droplets are ejected. Adjacent to the nozzles are ink chambers, where ink is stored prior to ejection through the nozzle. Ink is delivered to the ink chambers through ink channels in fluid communication with an ink supply. The ink supply may be, for example, contained in a reservoir part of the pen. For color printing, multiple colors are made available to the printer. For each color of ink there is a separate ink reservoir and ink delivery system coupled to a separate group of ink chambers and nozzles. In order to achieve high quality, high-resolution printing, these groups of nozzles are placed relatively close together on the printhead. Control of ink flow is required to prevent excess ink from being delivered to the printhead. Excess ink delivery leads to leakage, or drooling from the nozzles. Ink-jet printer systems are affected by changes in ambient conditions, such as temperature and pressure. When the ambient temperature increases or ambient pressure decreases, air diffused throughout the ink and air bubbles present within the ink reservoir expand to cause displacement of ink. Unless this expansion is managed, the displaced ink is forced out the printhead nozzles resulting in undesired drool. When an inkjet pen drools, one color of ink may migrate across the surface of the printhead to another color group. When ambient temperature or pressure changes, the migrated ink may be sucked back into the nozzles of another color ink. The mixing of these two ink colors causes contamination, producing poor quality printing. Open cell foam is often used to store ink within a reservoir of an ink jet pen. In conventional foam ink storage systems, the top of the reservoir may be vented to ambient to allow equalization of pressure within the ink container to the outside air pressure. However, substantially all of the exterior surfaces of conventional foam ink storage members are in contact with the walls of the pen reservoir. Such contact between ink saturated foam and the reservoir walls creates a seal through which air is unable to pass for venting to atmosphere. When changes in ambient conditions occur to expand air in the reservoir, the expanded trapped air displaces ink and causes drool through the nozzles. To control leakage, extra felting of the foam member has been employed. Felting is a measure of the extent to which foam is compressed. Compressing the foam decreases the pore dimensions. By increasing the felting of the foam (i.e., the amount of compression of the foam), pore size decreases and capillary force increases. A greater capillary force increases back pressure within the reservoir. An increase in back pressure within the reservoir helps to prevent drool. However, extra felting of the foam does not aid removal of air trapped within the foam. Extra felting also reduces the foam's ink storage capacity. Moreover, extra felting makes manufacturing difficult, as the foam is difficult to insert in the necessarily small reservoir. Grooved reservoir walls have been used to prevent ink drool. The grooves create a series of interconnected channels between the foam member and the reservoir walls. Expanding air from the foam's interior diffuses into these channels and is vented out of the reservoir. However, the grooved reservoir walls can be difficult to manufacture. Additionally, grooved reservoir walls can make the walls more flexible, and the pressure exerted by the compressed foam can deform the flexible reservoir walls so that the ink-jet pen does not fit properly within the printer. The present invention is directed to a system for storing ink in a pen reservoir, while preventing ink leakage due to a change in ambient temperature or pressure. The system comprises porous grooved foam. The porous foam is grooved on the exterior portion to provide paths for air to move to the atmosphere. Thus, air within the interior portion of the foam may expand to the grooves on the exterior portion. An atmospheric vent is in fluid communication with at least one of the grooves, thereby to vent excess air within the reservoir. The grooved foam may be used in any of a variety of ink-jet pen reservoirs and may be implemented with any foam-based pen.

Carbachol-induced hydrolysis of phospholipids in hippocampal slices may be mediated in part by subsequent activation of metabotropic glutamate receptors. We observed that AP-3, an antagonist of metabotropic glutamate receptors, reduced carbachol-induced hydrolysis of phospholipids in hippocampal slices. This inhibition could be explained in different ways, e.g.: 1) AP-3 acts also as antagonist of muscarinic receptors mediating the hydrolysis of phospholipids induced by carbachol, 2) Carbachol induces the release of glutamate which, by activating metabotropic glutamate receptors, leads to additional hydrolysis of phospholipids. The aim of this work was to test these possibilities. It is shown that AP-3 reduces carbachol-induced hydrolysis of phospholipids in hippocampal slices but not in cerebellar neurons at 10-14 days of culture, when these cells are not able to induce hydrolysis of phospholipids following activation of metabotropic glutamate receptors. It is also shown that carbachol induces a release of [3H]aspartate in hippocampal slices. The results reported suggest that the hydrolysis of phospholipids induced by carbachol in hippocampal slices would have two components. One part would be due to direct activation by carbachol of muscarinic receptors associated to activation of phospholipase C. This part would not be inhibited by AP-3. The second part would be due to subsequent release of glutamate and activation of metabotropic glutamate receptors. This part would be inhibited by AP-3.

Antibodies to squalene in recipients of anthrax vaccine. We previously reported that antibodies to squalene, an experimental vaccine adjuvant, are present in persons with symptoms consistent with Gulf War Syndrome (GWS) (P. B. Asa et al., Exp. Mol. Pathol 68, 196-197, 2000). The United States Department of Defense initiated the Anthrax Vaccine Immunization Program (AVIP) in 1997 to immunize 2.4 million military personnel. Because adverse reactions in vaccinated personnel were similar to symptoms of GWS, we tested AVIP participants for anti-squalene antibodies (ASA). In a pilot study, 6 of 6 vaccine recipients with GWS-like symptoms were positive for ASA. In a larger blinded study, only 32% (8/25) of AVIP personnel compared to 15.7% (3/19) of controls were positive (P > 0.05). Further analysis revealed that ASA were associated with specific lots of vaccine. The incidence of ASA in personnel in the blinded study receiving these lots was 47% (8/17) compared to an incidence of 0% (0/8; P < 0.025) of the AVIP participants receiving other lots of vaccine. Analysis of additional personnel revealed that in all but one case (19/20; 95%), ASA were restricted to personnel immunized with lots of vaccine known to contain squalene. Except for one symptomatic individual, positive clinical findings in 17 ASA-negative personnel were restricted to 4 individuals receiving vaccine from lots containing squalene. ASA were not present prior to vaccination in preimmunization sera available from 4 AVIP personnel. Three of these individuals became ASA positive after vaccination. These results suggest that the production of ASA in GWS patients is linked to the presence of squalene in certain lots of anthrax vaccine.

Without limiting the scope of the present invention, its background is described with reference to using optical fibers for communication in a subterranean wellbore environment, as an example. It is well known in the subterranean well completion and production arts that downhole sensors can be used to monitor a variety of parameters in the wellbore environment. For example, during a treatment operation, it may be desirable to monitor a variety of properties of the treatment fluid such as viscosity, temperature, pressure, velocity, specific gravity, conductivity, fluid composition and the like. Transmission of this information to the surface in real-time or near real-time allows the operators to modify or optimize such treatment operations to improve the completion process. One way to transmit this information to the surface is through the use of communication lines, such as one or more optical fibers, copper or metallic cables, or hydraulic or pressure lines. In addition, optical fibers may serve as sensors, where the optical fiber obtains distributed measurements related to a parameter along the length of the fiber. In a typical wellbore treating or stimulation operation, a lower portion of completion string including various tools such as sand control screens, fluid flow control devices, wellbore isolation devices and the like is permanently installed in the wellbore. The lower portion of the completion string may include various sensors, particularly, a lower portion of optical fiber. After the stimulation process, an upper portion of the work string including an upper portion of optical fiber is separated from the lower completion string and retrieved to the surface. This operation cuts-off communication between the lower string, which remains in place, and the surface. Accordingly, if information from the production zones is to be transmitted to the surface during later production operations, a connection to the lower optical fiber must be reestablished when the production tubing string is installed. It has been found, however, that wet-mating optical fibers in a downhole environment is very difficult. Difficulties due to lack of precision in the axial movement of the production string relative to the previously installed completion string are addressed, for example, in U.S. Pat. No. 8,122,967, to Richards, entitled Apparatus and Method for Controlling the Connection and Disconnection Speed of Downhole Connectors, which is hereby incorporated by reference for all purposes. Further disclosure regarding downhole connections can be found in U.S. Patent Application Publication 2012/0181045, to Thomas, entitled Apparatus and Method for Controlling the Connection and Disconnection Speed of Downhole Connectors, which is hereby incorporated by reference for all purposes. Additionally, wet-mate connections or wet-connects have become prevalent, especially in off-shore deep wells where it is difficult to provide for a dry-connection. A downhole communication line and a connector are often left in place, such as at the upper end of a completion string or production string. A second tool string is later lowered into the wellbore, also having a communication line and connector. The communication connectors are mated to provide an operable communication link between the tools. While it is possible to lower tool strings with all of the communication lines and corresponding conduits in place, there is increasing interest in wet-connect or wet-mate capabilities, that is, connections made in a wet environment. Further, it is often necessary or desirable to disconnect the tools and repeat the process, as later tools are inserted into the well, to speed and simplify equipment changes, replacement, or employ different tool configurations over time. Typically wet-connects are hydraulic or electric in nature, where a pressure-competent connection or an electrically isolated connection, respectively, must be created. These require a reasonably high degree of cleanliness and several methods are known to make these connections with varying success. With the increase in usage of fiber optic communication lines in particular, it has become critical to provide an especially “clean” connection between mating connectors. Fiber optic connections generally require relatively greater positional registration and cleanliness. Therefore, a need has arisen for apparatus and methods for wet-connecting optical fibers and other communication lines in a subterranean wellbore environment.

The present invention concerns a mobile telephony method and system. A system of the kind concerned is referred to as a xe2x80x9cGlobal System for Mobile communicationsxe2x80x9d (GSM). To describe it in a somewhat simplified manner, it includes mobile stations carried by respective users of the mobile stations, who are subscribers of the system. The mobile stations provide radio links with Mobile service Switching Centers (MSC). The MSCs have respective coverage areas. Each mobile station enables its user to be one party to a call linking it to at least one other party via a center visited by the mobile station. The center is the MSC in whose coverage area the mobile station is temporarily located. Beyond the center, the call in question travels through the remainder of the system and possibly, if the other party is not a subscriber of the system, via the Public Switched Telephone Network (PSTN). To enable call set-up and billing, each MSC stores the identity of each mobile station visiting the center and a Home Location Register (HLR) stores data concerning all the mobile stations of the system. The data in the HLR include the locations of the mobile stations, i.e. the identities of the MSC visited by the mobile stations. Many messages are sent to the HLR to ask it for information needed to set up calls passing through the system because at least one of the parties to be linked by such calls is a subscriber of the system. This is why the data in the HLR is individually updated each time a mobile station moves from one area to another and after each change of status of a user. The user""s status defines conditions under which the user has access to the system and is billed. It is part of the data concerning the user""s mobile station. The data is collectively backed up in another register. These operations are carried out periodically so that the back-up register does not contain locations of mobile stations which have moved since the last such operation. Some modifications, such as those concerning the status of some categories of users, are done in the back-up register first. Following any such modification in the back-up register, or following other incidents that can affect the validity of the data in the HLR, the data is collectively updated in an operation which is referred to as a xe2x80x9creset,xe2x80x9d that is based on data from the back-up register. The reset is reported to the MSC. On the first contact of a mobile station with the MSC it is visiting after a reset, the center sends the HLR a message to harmonize the data concerning the mobile station in the MSC and in the HLR. The location of the mobile station is updated in the HLR on the basis of the identity of the center sending the message and the data defining the status of the user of the mobile station is updated in the center from data contained in the HLR. Prior art systems of the above kind have the disadvantage that, when a system of this kind is requested to set up a call, call set-up is sometimes impeded by unavailability of the system, in other words the call request that requests call set-up is not completed even though the called party is available. An aim of the present invention is to provide a simple and low-cost way to limit such unavailability of the system. With this aim in view, the invention consists in a method which conventionally includes operations performed by a HLR containing respective data on a plurality of mobile stations. Each such operation consists in exploiting a message triggering the operation. To be able to select some of the messages in order to be able to exploit them in an overload situation, the HLR assigns each message a priority level chosen from a scale of such levels. Some of the operations effected by the HLR are collective updates of mobile station data. Each such update constitutes a reset and is reported to a plurality of MSCs each containing the data of the mobile stations located in the area of the center. Other operations are individual updates. Each such update consists in exploiting a message transmitted by a MSC and updates in the HLR the data of a mobile station constituting a station to which the message relates. Some of the individual updates are visit updates. A message requesting a visit update is transmitted by a MSC to exploit a visit notification reporting the arrival of the mobile station to which the message relates in the area of the center, the message constituting a visit request. Other individual updates are referred to as updates after a reset. A message requesting an update after a reset is transmitted by a MSC to exploit a contact between the center and the mobile station to which the message relates. It constitutes a request after a reset. It is transmitted when three conditions are combined: the mobile station is in the area of the center, the contact is after a preceding message transmitted by the center relating to the mobile station and requesting a visit update, and the contact is a first contact between the mobile station and the center since a reset was reported to the center. In the method of the invention the MSCs introduce a difference between visit update requests and update after a reset requests detectable by the HLR and by means of which the HLR assigns update after a reset requests a lower priority level than visit update requests. In the context of the present invention, it has been found that many instances of unavailability in prior art systems were related to the bit rate of messages sent to the HLR by the MSCs, the bit rate sometimes exceeding the HLR""s capacity to exploit such messages. It has been realized that abstaining from or delaying the exploitation of such messages would lead directly to only a few instances of unavailability of the system if such abstention were in practice limited to messages received by the HLR after a reset and at the same time as other messages needed to set up a call currently requested or requested afterwards. More particularly, it has been realized that there are then many fewer instances of unavailability than occur on abstaining from responding to the other messages in prior art systems. The present invention therefore avoids the additional cost that would be generated by increasing the HLR""s capacity for exploiting the messages it receives, at least when the increase in capacity would be sufficient to eliminate instances of unavailability linked to messages sent after a reset.

The present invention relates to a method of producing radiation sensors, in particular for infrared radiation, with an absorber for the radiation to be measured and a plurality of thermoelements for measuring the absorbed radiation-induced heating of the radiation absorber integrated into a semiconductor substrate. These methods can be used in particular for production of radiation absorbers with a plurality of sensor elements integrated at small distances on a substrate. Such a radiation sensor with a plurality of sensor elements and a method of producing same are described, for example, by I. H. Choi and K. D. Wise, xe2x80x9cA Linear Thermopile Infrared Detector Array with On-Chip Multiplexing,xe2x80x9d IEEE Trans Electron. Devices (September 1985), pages 132 through 135. This article describes a method whereby boron is diffused into a less than 100 greater than oriented silicon substrate in a ring pattern from the front side, a membrane of SiO2 and Si3N4 is created on the front side, and then openings are cut through the substrate from the rear side of the substrate by anisotropic wet etching. These openings end on the front side of the substrate within the ring-shaped areas doped with boron. This forms openings in the substrate that are closed only by the thin membrane. A radiation absorber is formed on the membrane in each of these openings. A plurality of thermoelements connected in series each has a hot contact in the vicinity of the radiation absorber and a cold contact on the remaining silicon substrate which functions as a heat sink. This known manufacturing method has a number of disadvantages. The anisotropy of wet etching occurs due to the fact that the etching process takes place at different rates on the different crystal faces of the silicon substrate. The etching rate is lowest on a surface with less than 111 greater than orientation. Therefore, in wet etching of a less than 100 greater than surface through an opening in a mask, a recess is formed in the surface, its side walls having less than 111 greater than orientations and being inclined at an angle of approx. 54xc2x0 to the less than 100 greater than surface. The bottom surface of the resulting recess is smaller the further the etching operation proceeds into the material, until it reaches a depth where the opposite walls of the recess abut against one another. Therefore, to produce a small opening at the level of the membrane, a mask with a much larger opening must be formed on the opposite side of the substrate. Fluctuations in thickness between different substrates or within a substrate have a critical effect on the dimensions of the opening produced in the membrane due to the inclined orientation of the walls. It is extremely difficult to produce precision openings with small dimensions in relation to the thickness of the substrate, because fluctuations in the thickness of the substrate have a great influence on their size. This problem is counteracted in the cited literature by the diffused ring made of boron. The boron-doped material is not attacked by etching, so the opening in the mask on the rear side of the substrate can be larger than would be necessary in view of the crystal geometry of the substrate to obtain a given opening size in the membrane. The size of the finished opening is then determined by the diameter of the undoped region inside the boron-doped ring. However, one unavoidable consequence of this method is that a portion of the rear side of the boron-doped ring which has diffused into the substrate is exposed so that the thickness of the substrate in the immediate vicinity of the opening after etching is determined by the thickness of the ring, which amounts to only approx. 20 xcexcm. Although a greater ring thickness could be achieved, this would be possible only through long diffusion times at very high process temperatures. This leads to the problem that, in the finished infrared sensor, the boron-doped ring may be eroded to varying extents by the etching process, resulting in variations in the quality of heat transfer from the cold contacts of the thermoelement over the ring into the solid silicon substrate, which can lead to systematic measurement errors. Another radiation sensor with a silicon substrate, a radiation absorber arranged on a membrane over an opening in the substrate and a plurality of thermoelements with a hot contact in the vicinity of the radiation absorber and a cold contact on the silicon substrate is known from German Published Patent Application No. 41 02 524. With this sensor, the walls of the opening also diverge toward the side of the substrate facing away from the membrane in the manner characteristic of anisotropic wet etching. The diameter of the opening is much greater than the thickness of the substrate. The present invention provides methods of producing radiation sensors which make it possible to produce radiation sensors with precisely reproducible properties and permit the production of radiation sensors with a plurality of individual sensor elements which can be arranged at a small distance from one another, which is independent of the thickness of the substrate used. According to a first aspect of the present invention, these advantages are achieved by the steps of forming an opening in the membrane in the specified area and etching the semiconductor substrate through this opening. This opening makes it possible to produce the required cavity below the radiation absorber from the front side of the substrate, thus eliminating the necessity of etching through the entire substrate in a time-consuming process. This eliminates possible sources of error in positioning the etching mask on the rear side of the substrate in relation to the position of the radiation absorber, as would otherwise be necessary; there is no danger of extensive etching beneath the edge areas of the opening where cold contacts of the thermoelement can be mounted, which would thus result in poor thermal contact with the solid silicon substrate; furthermore, there may be solid unetched semiconductor material a short distance below the radiation absorber, which increases the total mass of the heat sink formed by the semiconductor material. According to a first variant of this method, wherever a recess is to be created, the semiconductor material is made porous in that area prior to deposition. This can be accomplished by an anodic oxidation, e.g., with an HF electrolyte, in an electrochemical process in which the wafer functions as the anode with respect to the electrolyte. This region, which has been made porous, can then be etched out selectively in a subsequent etching step. This etching step preferably takes place after the membrane has been deposited and the thermoelements have been structured on the membrane. To determine the area to be etched out, in this case the surface of the semiconductor substrate is preferably masked with a protective layer made of a material which is resistant to the agent used to make the semiconductor porous. This material may be chromium or gold, for example. As an alternative, the areas to be etched out can be determined by low n-type doping (nxe2x88x92 doping) of the areas that are not to be etched away, so that in contrast with the p-doped substrate and any n++ doped areas, they are not attacked by the agent used to make the semiconductor porous. The etching step which follows the step of making the semiconductor porous may be a traditional wet etching step. The thermoelements are preferably structured on the deposited membrane before the etching step. No special masking is necessary for the etching step if the material to be etched out has been prepared by making it porous. According to a second variant of this method, no preparation of the area to be etched out by making it porous is necessary, and instead the area to be etched out is determined only by the formation of the opening in the membrane. The recess can be produced easily by isotropic etching of the substrate area behind the opening. This isotropic etching can be performed by electrochemical anodizing followed by dissolving, by direct electrochemical dissolution or by isotropic wet etching, e.g. HNA (HF+NHO3+CH3COOH). In this second variant, however, dry etching methods are preferred, such as plasma etching or spontaneous dry etching, because gaseous etching media can penetrate more easily than liquid media into the area to be etched away behind the opening, and because the mass exchange through the opening is more effective. In particular, plasmas of F2 in Ar, SF6 or NF3 may be used for plasma etching. Gases such as XeF2, CIF3 or BrF3 which erode silicon immediately on coming in contact with it in a violent reaction, forming volatile SiF4, may be used for spontaneous dry etching. According to a second aspect of the present invention, a method is to be provided of producing a radiation sensor on a semiconductor substrate by performing the steps of establishing at least one area on a first surface of the substrate, in which an opening is to be created in the substrate, depositing a membrane on the first surface of the substrate, applying a radiation absorber to the membrane, applying thermoelements with a hot contact in thermal contact with the radiation absorber and a cold contact in thermal contact with the semiconductor substrate, and applying a mask to a second surface of the semiconductor substrate (the rear side) which is opposite the first surface. According to this method, the mask has an opening congruent with each area thus determined, and the second surface is treated by anisotropic dry etching until the silicon substrate has been etched away in the areas determined. Suitable anisotropic dry etching methods are described in German Published Patent Application No. 42 41 045. The plasma etching processes described there make it possible to produce openings in the semiconductor substrate with walls almost perpendicular to its surface, thus eliminating the necessity for making the openings in the etching mask on the second surface of the substrate much larger than the finished openings by including a lead produced later in the substrate at the level of the membrane. Not only does this eliminate possible sources of error in producing and positioning the mask, it also yields the possibility of arranging the individual openings at a much smaller distance from one another which no longer necessarily depends on the thickness of the substrate. The cross-sectional dimensions of the openings in the semiconductor substrate are constant over the thickness of the substrate, so that there are no losses of surface area and a dense packing of openings is possible. It is readily possible to produce an opening in a substrate up to 700 xcexcm thick merely by anisotropic dry etching as described in the aforementioned publication. According to two advantageous embodiments of the method, however, the openings are produced in two steps. In the first embodiment, first a contiguous area of the substrate is eroded by etching, thereby producing the second surface on which the actual etching mask is applied. Any desired etching method, preferably a rapid etching method, can be used for this etching. As an alternative, dry etching itself may be subdivided into two steps, with etching being performed only in the congruent openings in the mask in the first step and then performed on a contiguous area having several congruent openings. Due to the first step, the congruent openings have a certain xe2x80x9cprojectionxe2x80x9d over the contiguous area surrounding them, and this is preserved in the next step of etching the contiguous area. The result of these two methods is a substrate with a contiguous recessed surface on the rear surface of the substrate and a plurality of openings extending from the surface to the membrane on the front surface of the substrate. The individual openings are separated by webs of semiconductor material, although the thickness of these webs is not that of the original substrate, but it is constant and reproducible for each individual opening, and thus for each individual radiation absorber arranged in such an opening it forms a uniform thermal tie to the heat sink formed by the semiconductor substrate. To form an effective heat sink, the webs of semiconductor material should be at least 50 xcexcm thick. Etching should thus proceed at least to this depth in the congruent openings. At a high aspect ratio of the openings, it becomes more and more difficult for the material etched away to be removed from the openings, and furthermore, on reaching the membrane, there is the risk of notching at the interface between the semiconductor substrate and the membrane, so it may be expedient to limit the depth of etching in the congruent openings, e.g., to a value of 100 or 200 xcexcm. A two-layer mask is preferably used for two-step dry etching, with an opening that corresponds to the contiguous area being formed in a first masking layer and with the second layer containing the congruent openings. In the transition between the two etching layers, only the second layer of the mask need be removed selectively. For example, an advantageous combination would be to use photoresist masking and SiO2 as a hard mask or a nitride oxide layer system such as that described in German Published Patent Application No. 41 29 206.

Surgical treatment using a medical needle such as ablator or biopsy has recently become popular due to relatively small incisions made in such a procedure. The surgical treatment is performed by inserting the medical needle into an internal region of a human body while referring to an internal image of the human body. Such surgical treatment, which is performed while observing internal organs of the human body with the help of a diagnostic imaging system, is referred to as an interventional treatment. The interventional treatment is performed by directing the medical needle to a lesion to be treated or examined through a skin with reference to images during the treatment. The images are acquired by employing a computerized tomography (CT) scanner, which is generally used in a radiology department, or a magnetic resonance imaging (MRI) system. Compared to a normal surgical treatment requiring relatively wide incisions to open the lesion, the interventional treatment has the advantages of low costs and obtaining effective operation results. This is because general anesthesia is not necessary for the interventional treatment and patients are subjected to less pain while benefiting from rapid recovery. However, it is difficult to obtain such images in real time by using the CT scanner or the MRI system. Especially, when the interventional treatment is performed by using the CT scanner, both the patient and the operator are exposed to radiation for quite a long time. However, when the interventional treatment is performed by using an ultrasound diagnostic system, the images can be obtained in real time without affecting the human body. But, there is a problem since it is difficult to accurately recognize the lesion as well as the medical device (i.e., a needle) in the ultrasound image obtained by using the ultrasound system.

MOHALI: Claiming to be the only hostage to have survived after being abducted along with 40 others by Islamic State of Iraq and Syria (ISIS) on June 11, 2014, Harjit Masih on Thursday said that he his fellow workers were shot down in strife-torn Masul city of Iraq.Masih claimed, “The ISIS took away nearly 100 workers including Indians and Bangladeshis to an undisclosed location and after keeping us in a furnished accommodation for 4 days, the Indians were taken to another place in rough terrains.”“They opened fire and as every other Indian around fell died, I got lucky with a bullet only bruising my leg. A fellow Punjabi’s body sheltered me. I pretended to be dead and escaped after some time. However, on reaching a main road, the person who gave me lift took me back to my abductors the same night,” claimed Masih, who tried hard to prove his point amid intensive questioning.Masih said he joined a group of Bangladeshis to survive after escaping the ISIS. A resident of Gurdaspur district, Masih said he had no interest in telling a lie about the fate of the abducted Indians.AAP's Sangrur MP Bhagwant Mann alleged that the Centre had messed up in handling the entire issue. “Masih got in touch with me two days back and I called him over to tell the story,” he said.

Purkinje cell evoked unit activity in developing normal and undernourished rats. Purkinje cell evoked unit activity was studied in developing normal and undernourished postnatal rats from 5 to 30 days. Ipsilateral electrical stimulation of the sciatic nerve, induced mossy fiber (MF) mediated simple spike activity or climbing fiber (CF) mediated complex multiple discharge activity. MF mediated response exhibited the phenomenon of electrical fatigue, while CF mediated response was augmented on repeated peripheral stimulation. Undernourished rats exhibited irregular and reduced spike amplitudes, spike frequencies, significantly increased stimulus thresholds and increased biological variabilities in their response on repeated electrical stimulation as compared to normal animals which exhibited a typical graded response at increasing stimulus frequencies and stimulus intensities. The after-hyperpolarization duration was also significantly increased in the undernourished as compared to normal rats. These data suggests that undernutrition, imposed during the lactation period can induce impairments in the Purkinje cell membrane dynamics and delays MF as well as CF mediated functional maturation in the developing cerebellum, which may induce delayed motor learning in young undernourished individuals.

Postural control and attentional demand during adolescence. In the present study we aimed to determine the attentional cost of postural control during adolescence by studying the influence of a cognitive task on concurrent postural control. 38 teenagers aged 12 to 17years and 13 young adults (mean age=26.1) stood barefoot on a force platform in a semi-tandem position. A dual-task paradigm consisted of performing a Stroop or a COUNTING BACKWARD task while simultaneously standing quietly on a firm or foam support surface. Different centre of pressure (CoP) measures were calculated (90% confidence ellipse area, mean velocity, root mean square on the antero-posterior (AP) and medio-lateral (ML) axes). The number and percentage of correct responses in the cognitive tasks were also recorded. Our results indicate (1) higher values of surface, ML mean velocity and ML RMS in the COUNTING BACKWARD task in adolescents aged 12 to 15 than in teenagers aged 16 to 17 and in adults, regardless of the complexity of the postural task and, (2) better cognitive performances in the Stroop than in the COUNTING BACKWARD task. The difference in the dual-task performance between the different age groups and particularly the existence of a turning point around 14-15years of age might be due to 1) difficulties in properly allocating attentional resources to two simultaneous tasks and/or, 2) the inability to manage increased cognitive requests because of a limited information processing capacity in adolescents aged 14-15years.

Computer and other electronic assemblies typically include a plurality of printed circuit (PC) boards that support electronic components. Commonly, PC boards are secured within a steel or plastic chassis for an electronic assembly by means of screws extending through holes in the PC board and threadedly engaged to a portion of the chassis. In addition to the mounting screws, the assignee of the present invention also has used an alternative PC board mounting technique by which vertically-extending plastic hooks are molded into the base of the computer chassis. The hooks are received through slots formed in a PC board as the PC board, lying in a horizontal plane, is lowered onto the base of the chassis. After the PC board is seated on the chassis, with hooks extending through slots, the PC board is displaced horizontally to engage the hooks on the upper surface of the PC board at one end of the slots, thereby preventing vertical motion of the PC board. Thereafter, a small plastic catch mechanism is snapped into engagement with an edge of the PC board to prevent horizontal motion. Because of the sensitivity of electrical components, and the risk that electrical circuits may be shorted if not properly secured within the product, it is necessary to ground the circuit board and to provide a ground for the electrical components on the circuit board. In many instances, both of these functions are provided by the fasteners (screws and/or hooks) that extend through the circuit board to the chassis of the product. Thus, for example, in a personal computer chassis, the motherboard containing many of the computer's electrical components is fastened to the chassis by a plurality of mounting screws and/or hooks. Because the chassis usually is constructed of a conductive material, or contains a conductive layer, a path to ground is provided through the mounting fasteners. The grounding of the circuit board is necessary to provide shielding against electromagnetic interference ("EMI") from outside sources, which might otherwise disturb the operation of the components on the circuit board. As one skilled in the art will understand, a large variety of electrical components may be mounted on the circuit board, including integrated circuits and other discrete components. Typically, the electrical components are mounted on the circuit board in one of two ways. The first technique for mounting electrical components on a circuit board is to provide electrical leads on the electrical components that extend through the circuit board. The tips of these leads then are bent and/or soldered to an outer surface of the circuit board. Where space is limited, solder usually is preferred as a method to both secure the electrical component to the circuit board, and to provide a high quality electrical connection between the leads and the circuit paths on or in the circuit board. In order to perform this soldering process, usually a wave soldering machine is used to provide the requisite soldering of connections on one or both sides of the circuit board. Typically, the circuit board is placed in the wave soldering machine so that solder is applied to all conductive surfaces on the bottom of the circuit board. In addition to providing solder to the leads of the electrical components, solder also is applied to conductive pad surfaces on the solder-side of the circuit board during the wave soldering process. To the extent that conductive surfaces on the solder-side of the board are not to be soldered, a solder mask must be provided as the bottom layer of the circuit board. The solder mask resists the application of solder. Thus, in accordance with normal techniques, the solder-side surface of the circuit board is designed with conductive pads, such as copper, where solder is to be deposited during the wave soldering process. Some of the larger conductive pads that are provided on the bottom of the circuit boards are the grounding pads, where grounding screws and/or hooks are to be attached or mounted. Printed circuit boards typically are designed in layers, with various circuit paths, and in some instances, circuit elements, in each layer of the board. Thus, a typical circuit board has a number of different layers, with the upper and lower layers including circuit paths for connecting to components that are mounted to the top or bottom of the circuit board. In prior art circuit boards, typically a plurality of "plated through holes" are provided for receiving the grounding screws. As that term is conventionally used, plated through holes are holes drilled through the circuit board, which include a conductive material applied to the board at the periphery of the mounting hole so that each layer of the circuit board can be electrically connected to the grounding screw. In addition, a solid conductive (copper) pad typically is provided on external layers of the board adjacent the aperture for the screw. The upper pad functions to connect to the head of the screw, while the lower pad functions to connect to the body or chassis of the product in which the board is mounted. Solder tends to wick through the plated through holes, and to accumulate in large mounts on the relatively large pads. Because solder is not applied evenly in the wave solder process (based upon various considerations such as surface tension, etc.), after soldering the solder deposited on the conductive pads and plated through holes tends to be uneven, and in fact, relatively large bumps or clusters may appear at one portion of the pad while other portions have relatively large valleys. This problem is greatly exaggerated on larger pad areas, such as the grounding pads. Because of these abnormalities in solder heights at the grounding pads and plated through holes, the installation of the boards may prove difficult, if not impossible. For example, in assignee's personal computers, hooks are used to secure the motherboard to the chassis. The hook therefore functions as a clamp by sandwiching the motherboard in place. See U.S. application Ser. No. 08/179,806, filed Jan. 11, 1994, the teachings of which are incorporated by reference as if fully set forth herein. The hook has a certain clearance to accommodate the circuit board. If the conductive pads at the site of the hook are too high, the circuit board will not fit within the hook structure. If, conversely, the height of the solder is too low, the conductive pad will not make a good contact with the hook and/or the metal chassis of the product in which the board is mounted, causing potential problems with electromagnetic interference. Moreover, if the height of the solder varies from one pad to another, the board will not lie flat within the chassis, but instead will be required to flex and bulge to fit properly in the chassis, causing stress on the circuit board. To alleviate these problems it typically is necessary to manually touch-up the larger solder pads in order to remove excess solder, or to add solder to provide a uniform solder height. This manual rework of the PC board adds significantly to the cost of manufacturing the circuit boards. Consequently, it would be advantageous to develop a technique for uniformly depositing solder on a circuit board during a wave soldering process to provide a solder joint with sufficient quantities of solder to provide adequate EMI protection, without providing too much solder to create problems with installation. A second common technique for attaching electrical components to circuit boards is to surface mount the components by placing the component on conductive solder pads on the surface of the board. The solder then is heated in an appropriate chamber to reflow the solder on each pad to obtain a soldered connection with an associated lead or pad on the component. During the assembly of the circuit board, solder paste typically is deposited on the board by an automated (solder paste screening) machine, so that the solder paste is deposited in a relatively uniform manner to all of the conductive surfaces on the board. In addition to providing conductive paths for connecting to the leads of the surface mount components, it is common to also deposit solder paste on larger conductive pads where grounding is necessary, for example, where grounding screws and other attachments are to be located. In the situation where the conductive pads are relatively large, the solder paste deposited on these pads tends to flow unevenly over the entire pad boundary when the reflow process occurs, leaving minimal or no solder height to electrically connect to the components provided on the chassis for grounding. There is a need to control and maintain the flow of the solder during the reflow process, to achieve enough solder raised above the surface in a desired area to provide a high quality electrical connection. In many applications, such as computer motherboards, both types of components (surface mounts and through-hole) are used on the same circuit board. Typically, the surface mount components are soldered first on one side of the board, and then the board is placed in a wave solder machine to wave solder the other side of the board to connect the through hole devices to circuitry on the circuit board. In this situation, the problems with surface mount soldering and wave soldering are both present. It obviously would be advantageous to develop a method for constructing a circuit board which would provide a uniform solder height for the larger solder areas to facilitate ease of installation and to insure adequate grounding for EMI protection regardless of the type of soldering that is used or the type of circuit board that is implemented.

1. Field of the Invention This invention relates to age verifiers, and in particular to method of age verification for electronic media. 2. Background of the Invention A variety of internet web sites exist which are not appropriate for access by children. These may include gambling sites, chat rooms whose subject(s) are not appropriate for children, adult sites, etc. Many believe it is primarily the responsibility of the parent or guardian to monitor the type of web sites and television a minor is exposed to. However, it would be desirable to provide an additional mechanism to prevent minors from accessing inappropriate web sites. A variety of age verification systems have been used, such as credit card-based membership subscriptions, age verification system (“AVS”) firewalls, and the now discredited “I'm over 18, let me in” button. Although the Child Online Protection Act (“COPA”) (at last notice declared unconstitutional on First Amendment grounds) creates a “safe harbor” under which webmasters can rely upon the AVS or credit card solution as a defense to any claim that they are providing harmful materials to minors, no court has recognized the legal validity of a simple click-through screen where the user asserts that he or she is an adult. There are a number of problems associated with these proposed age verification mechanisms. First, while implementation of credit card or AVS screens to block material that is harmful to minors may be somewhat effective, its consequential effects do not pass constitutional muster. Initially, users may be less likely to access protected speech if they are required to provide personal information, including names, addresses and credit card numbers. The Third Circuit Court of Appeals specifically found that Web users are simply unwilling to provide personal information in order to gain access to sensitive or controversial content. Secondly, a distinct set of constitutional concerns are presented where individuals are required to pay even small amounts of money for access to protected communications. Finally, aside from the constitutional concerns, many credit card issuers object to the use of their credit cards for age verification purposes. Thus, given the substantial lobbying power of the merchant banks, it is anticipated that any new legislation proposed by Congress will likely not include the credit card option as an acceptable method of age verification. Despite the fact that COPA has been enjoined on multiple occasions, it is still advisable for adult webmasters to comply with the dictates of this law. First, the government has never promised that it will not attempt to retroactively prosecute those who are not in compliance, if the law is ultimately upheld by the United States Supreme Court. Secondly, it is simply the right thing to do to keep minors from accessing adult materials from a legal and moral standpoint. Importantly, a number of states have passed laws prohibiting businesses from providing adult materials to minors, and many of these laws appear to apply to online communications. Although some such laws have been declared unconstitutional, there is no guarantee that a criminal case won't be filed against an adult webmaster that is providing adult materials to minors without any form of age verification. Furthermore, although the issue of harmful materials is completely distinct from that of obscenity, obscenity cases become much harder to defend if the government can show that the allegedly obscene materials were also available to minors. So what is a webmaster to do? To start out with, it should be noted that the COPA law recognizes several “affirmative defenses” to prosecution for providing harmful materials to minors. COPA's affirmative defense provision reads as follows: Defense. It is an affirmative defense to prosecution under this section that the defendant, in good faith, has restricted access by minors to material that is harmful to minors— (A) by requiring use of a credit card, debit account, adult access code, or adult personal identification number; (B) by accepting a digital certificate that verifies age; or (C) by any other reasonable measures that are feasible under available technology. [Emphasis added.] It is the third COPA affirmative defense that forms part of the inspiration for the instant invention. Similarly, may states' laws provide a defense to this type of charge if the business uses “good faith efforts” to keep adult materials away from minors, such as placing adult magazines behind a store clerk's counter, out of reach of children, and blocking the front covers. So what are acceptable “good faith” efforts to verify age without requiring personal identification and/or credit card payments? A solution embodied in the instant invention utilizes both the Unsworn Declarations Act, 28 U.S.C. §1746, and the Electronic Signatures Act, 15 U.S.C. § 7000, et seq., to allow the user to certify his or her date of birth and to provide that information under penalty of perjury, before gaining access to inappropriate materials. The mechanism taught in the instant disclosure automatically checks the current date on the server, to determine if the individual user is over the minimum appropriate age on that date, based on the birth date provided under penalties of perjury. If yes, the user can gain access to the free areas of the web site, without becoming a member, paying any money, or providing credit card information. The effectiveness of the instant procedure depends on the use of the specific verified declaration language under federal law, and reference to the Electronic Signatures Act, allowing the user to provide a statement made subject to the penalties of perjury before gaining access to the site. From a legal standpoint, this procedure is superior compared to simply clicking “I'm over 18” which has become something of a national joke in the courts, and will likely not provide an effective argument that the site has made a good faith effort to exclude minors from the free areas. Requiring the user to verify his or her birth date accomplishes a number of things. First, in the event a minor submits a false birth date to gain access to the site, such misrepresentation will constitute an act of perjury, under federal law. The courts are less sympathetic to the claims of minors who commit felonies to obtain access to adult materials. When weighing the relative equities between a webmaster attempting to exclude minors, and a minor committing perjury, it is hoped that the courts will be more sympathetic to the former. This situation is akin to the store clerk who is provided a fake driver's license by a minor in the attempt to purchase tobacco products. However, in this case, the information is being provided under oath. A second advantage of the instant mechanism is the fact that, other than the birth date, no identifying information is being sought from the user. Some users may wish to remain anonymous, and these users will not be significantly deterred by providing a birth date, especially when the user's corresponding address or credit card number is not also required. This solution may address the constitutional concerns noted by the Third Circuit Court of Appeal where users are required to pay or provide personal identifying information before gaining access to adult materials.

During vertebrate CNS development, individual neurons make the decision to continue proliferating or exit and enter differentiation. These two opposing processes must be balanced else developmental abnormalities result, which can lead to dysfunction in the adult. The genes which control this process are largely unknown. The cerebellum is an excellent system to study this process because of its simple anatomy and its continued development postnatally making it more accessible for experimental analysis. Thousands of genes have been identified by the genome projects and with the advent of microarray technology it is now possible to compile a compendium of gene expression for any cellular population. A goal of this project is to generate an inventory of genes that are involved in the transition of a particular cerebellar neuron called the granule cell from a proliferative to a differentiated state by using the Affymetrix murine microarrays. Candidate genes that are differentially expressed will be tested for their function in this process by retroviral infection in vitro and a mouse transgenic tet inducible system in vivo.

The process for ordering memorialization and architectural products, such as plaques, signage, grave markers, or the like remains largely a manual process. In general, customers fill out paper order forms at the premises of a vendor and/or mail or fax completed order forms to a manufacturer. This process, for both vendor and customer, is tedious and error-prone and often causes the vendor to miss out on sales opportunities. Technological advances have introduced computer forms and web-based interfaces for entering customer orders. However, these still require a customer to make numerous selections and to navigate through several, if not all, pages of options in order to view choices that may be of interest. As such, computer-based ordering systems remain inefficient and do not operate to actually enhance sales for vendors. Accordingly, a system that allows a customer to effectively access design choices of interest and to customize a product would greatly benefit the memorialization and architectural products industries.

What can we learn from patients to improve their non-invasive ventilation experience? 'It was unpleasant; if I was offered it again, I would do what I was told'. Non-invasive ventilation (NIV) is widely used as a lifesaving treatment in acute exacerbations of chronic obstructive pulmonary disease; however, little is known about the patients' experience of this treatment. This study was designed to investigate the experiences and perceptions of participants using NIV. The study interprets the participants' views and explores implications for clinical practice. Participants with respiratory failure requiring NIV were interviewed 2 weeks after discharge. A grounded theory methodology was used to order and sort the data. Theoretical sufficiency was achieved after 15 participants. Four themes emerged from the data: levels of discomfort with NIV, cognitive experiences with NIV, NIV as a life saver and concern for others. NIV was uncomfortable for participants and affected their cognition; they still reported considering NIV as a viable option for future treatment. Participants described a high level of trust in healthcare professionals and delegated decision-making to them regarding ongoing care. This study provides insights into ways clinicians could improve the physical experience for patients with NIV. It also identifies a lack of recall and delegation of decision-making, highlighting the need for clinical leadership to advocate for patients.

Physical fitness characteristics of Omani primary school children according to body mass index. There is evidence that children with high cardiorespiratory fitness and normal body mass index (BMI) have less risk of non-communicable diseases (NCDs), however limited research was undertaken in Omani children. Therefore the aims of the present study were to describe body composition and physical fitness of a large cohort of Omani school children of both genders, and to investigate the effects of weight status on physical fitness. Three hundred and fourteen Omani school children aged 9 to 10 years old took part in anthropometric assessments, body composition and fitness tests, including handgrip strength, the basketball chest pass, broad jump, 20-m sprint, four 10-m shuttle agility, 30-s sit-up, and multistage fitness test (MSFT). Obese boys and girls performed worse than normal-weight children in sprint, agility and endurance. In addition, fitness measures in the overweight group and underweight groups were not significantly different from other groups, except a better handgrip strength and poorer MSFT in overweight compared to normal weight girls, and poorer agility performance in underweight girls compared to the three other groups. Most fitness measures are lower in obese Omani children, which suggests that they will be more at risk of developing NCDs later in life.

The invention relates to a radiant unit in the form of a portal equipped with a plurality of infrared lamps for use as a drying and baking unit and in particular for use as a drying and baking tunnel in the automobile industry. From pamphlet Q-E1/14OP (April 1974 edition) of Heraeus Quarzschmelze GmbH, modular medium-wave infrared lamps are known which can be assembled in modular fashion to form planar infrared radiant units. For use in larger structures, these heating elements can be suspended from frames. Such modular lamps are used for drying and heating in the manufacture of small parts, in laboratories, and in the forming of thermoplastics. For drying and baking of surface coatings, particularly in the automobile industry, the use of installations with infrared lamps of the type referred to above, for example, has proved highly advantageous since such installations can be kept very short, and since the heat required by the process can be directed onto the object with high precision. The ovens used in the automobile industry are constructed in the form of a portal equipped with individual infrared lamps and having a relatively short overall length, that is, an overall length considerably shorter than the vehicle being conveyed through the portal. In such drying and baking operations, it is important that the volatilized solvents, or other vapors or suspended particles present in the space, not deposit on the object being treated. Thus the air in the heating chamber surrounding the portal is continuously exhausted and cleaned, and filtered air is introduced.

The semiconductor integrated circuit industry has experienced rapid growth in the past several decades. Technological advances in semiconductor materials and design have produced increasingly smaller and more complex circuits. These material and design advances have been made possible as the technologies related to processing and manufacturing have also undergone technical advances. In the course of semiconductor evolution, the number of interconnected devices per unit of area has increased as the size of the smallest component that can be reliably created has decreased. Many of the technological advances in semiconductors have occurred in the field of device fabrication. As device densities continue to increase and feature sizes continue to decrease, device fabrication processes must constantly adapt and improve. One such process includes the use of photolithography with a mask. During photolithography a pattern is defined on the surface of a substrate through the use of light shined through or reflected off a mask. The pattern is typically used to identify two regions on the substrate: a first region that will be exposed to a further processing step and a second region that will be protected from the same further processing step. For example, the pattern might divide the substrate into regions where material is to be deposited or not deposited. In another example, the pattern might divide the substrate into regions where material is to be etched away or should remain. Accordingly, it would be desirable to have improved photolithography patterns and methods. The various features disclosed in the drawings briefly described above will become more apparent to one of skill in the art upon reading the detailed description below. Where features depicted in the various figures are common between two or more figures, the same identifying numerals have been used for clarity of description.

"If the post office can't deliver or return a package, it ends up here." "The dead letter office." "They prefer Mail Recovery Center." "I guess it sounds classier." "Twice a year, we open the boxes, put pricey stuff in the auction bin, cheap items go in the garbage, and the ones in-between sometimes disappear." "Isn't that stealing?" "It's repurposing." "See, I can class it up, too." "(chuckles)" "Oh, nasty." "Old food." "That's an animal." "I found a dead cat once." "Early retirement is looking good." "(screams)" "That's it-- I retire." "Welcome to the U.S. Postal Service, kid." "(gasps)" "BRENNAN:" "This house would be perfect for us." "BOOTH:" "Is it $30 million?" "Because, you know, I'm not a best-selling author." "No, it's very reasonable." "I'll be the judge of that." "Wow, look at that, it's nice." "There's a pool." "Costa Rica?" "There is a little known tribe there that I could study, and it is a beautiful country to raise a child." " Very little crime." " Crime?" "I thrive off crime-- that's my job." "Well, with your restrictions," "Booth, you make it very difficult to find something in the D.C. area." "Wait, what about Maryland?" "Maryland's a great place." "The Bureau just confiscated this..." "Hey, shrimp." "Hey, Pops." "What are you doing here, huh?" "Why didn't you call?" "What, and waste a dime?" "(laughs)" "Come on, have a seat, huh?" "Oh, you look just beautiful." "You know, I never thought" "I would be a great- grandpa again." "Here, you want to feel her kick?" "So what..." "what happened?" "They kick you out of the retirement home?" "No." " They put up with me." " Mm-hmm." "Could we go somewhere else?" "I-I don't want to talk here." "Why?" "Is everything okay with you?" "It's not me, Seeley, it's your dad." "Oh, right." "What did he do this time?" "He's gone." "He died Monday at the V.A." "Oh, no, I'm..." "I'm so sorry, Booth." "What happened?" "(phone ringing) Liver failure." "I guess that drinking finally caught up with him." "Hm." "Doesn't surprise me." "Booth." "Great." "All right, we're on our way." "Just text me the address." "Okay, let's go." "We got a case." "I'm sure someone else can handle it, Booth." " Why?" "HANK:" "Seeley," "I know how you felt." "Then you shouldn't be surprised how I reacted, huh?" "You got a key to my place." "Make yourself at home, we'll have some grilled cheese later on." "Come on, Bones, let's go." "Take care of him, Temperance." "BOOTH:" "Ready?" "You sure you're okay?" "Yeah, I'm fine." "Another day, another crime." "(sighs)" "BRENNAN:" "The wear on the lower incisors and mandibular angle indicate a male in his early 20s." "This body part was dismembered at a cervical vertebra." "This box shows a slice at the acromial processes of both scapulae." "This is certainly a first for me." "Me, too" " I have never seen this part of the post office before." " Yes." "I thought they sent the dismembered bodies to a completely different place." "That's, uh, whoa, wow, oh, God." "I agree." "But it's packed very nicely." "I wonder if the killer does gift wrapping on the side." "Well, we almost wrapped up here?" "Does this look like a routine case to you, Seeley?" "Are you sure you're okay, Booth?" "Would you stop?" "I'm fine." "Is something wrong?" "Nope." "His dad died." "(groans) Oh, my God." "Really?" "Why would you say that?" "What?" "I was just trying to be supportive by adopting a matter- of-fact demeanor, like you." "If you'd like to..." "I don't." "I just want to know who sliced and diced this guy up and put him in boxes." "That's all I'd like to know." "♪ Bones 7x04 ♪ The Male in the Mail Original Air Date on December 1, 2011" "♪ Main Title Theme ♪ The Crystal Method == sync, corrected by elderman ==" "♪ ♪" "The body lipids combined with the packing materials and transformed the tissue into an adipocerous gel." "Yeah, I'm pretty sure my middle school served this for dessert." "Unless we can separate them, the packing material is going to contaminate any tests I run on the tissue." "And I need to separate these bones before there's any more chemical damage to them." "I've got just what you need, Clark." "This little puppy is a plycimer laser." "Now, who wants to hear it bark?" "Aren't those used for eye surgery?" " Yeah." "Gotta be an eye in here somewhere, right?" "Now, I've set it so that it'll zip through the goop and separate it from the cardboard." "Hm." "Can't we just cut the box open?" "But I already signed this out." "And it's much cooler." "Trust me." "Okay." "(clears throat)" "Okay, I think." "Here we go." "Okay, that is cool." "And once the bones are removed, we can separate the packing material from the decomposed organs and tissue." "Excellent, Dr. Hodgins." "Yeah." "Okay." " Okay, ready?" " Mm-hmm." "(groans)" "Okay, uh, tray." "Right." "Ladies and gentlemen, our first bone." "And only 205 more to go." "Okay, my turn." "Oh, hey, hey!" "I called dibs." "Hey, but..." "I'm the boss." "Oh, uh-huh." "For you, sir." "What's this?" "I had an evidence response team run the shipping information from the packages." "Who requested this?" "I figured you'd want them and I know how busy you are, so... (chuckles)" "Uh, it turns out that neither the shipping addresses nor the return addresses exist." "Ah, so the labels were created so the body would end up in the dead letter office." "Exactly." "Maybe we can find out where these labels were created." "I'm gonna call..." "I actually sent them over to Ms. Montenegro at the Jeffersonian." "(chuckles)" "I figured that's what you would do." "You know, Shaw," "I am not authorized to give you a raise." "You're the best agent in the department, sir." "I just really wanted the opportunity to work with you, and if I can help during this time of your loss..." "Oh, so the techs were talking at the scene." "They were concerned." "We all are." "There's a chopped-up body at the lab, so if you want to help, let's just focus on the case, right?" "Yeah, okay, of course." "Um, the boxes containing the remains were packed to the specifications of the American Society for Testing and Materials, and they're the gold standard in shipping." "So, professionally packed and shipped but never intended to reach a destination." "That's a great way to get rid of a body." "You found an anomaly, Dr. Edison?" "Yes, as I was cleaning the bones, I noticed a sesamoid..." "An ossified node?" "Where was it?" "Huh?" "Oh, uh, it was on the, um, second metacarpal, on the left hand." "(grunts)" "Have you determined the weapon that... that, uh, dismembered the victim?" "Um..." "(clears throat)" "The lack of kerf marks would suggest that we're looking for a toothless blade, s-something uniform with vertical striations that, uh..." "Dr. Edison, is there a problem?" "You're staring at my breasts." "Oh, oh, no, no, oh, I-I'm sorry, Dr. Brennan, uh, but you were, um..." "Look, there was a whole lot of activity going on there, and I was just thinking, you know, maybe I could help you out." "Not meaning like that, because I would never..." "Tender and swollen breasts are common in the third trimester." " Of course." " It's very uncomfortable." "My bra size has increased by two cup sizes." "I hadn't noticed." "Well, it's quite obvious." "You should be more observant, Dr. Edison." "Yes, I'm sorry." "Oh, I see now." "They are much larger." "(clears throat)" "Can I just, uh, focus on these remains?" "Yes." "I need a weapon and Booth needs an I.D., so run a search using the victim's dental X-rays." " Of course." " I need to find some ice packs." "Maybe that will help." "Dental X-rays, weapon, ice packs." "(sighs)" "MONTENEGRO:" "So when you create a shipping label on the post office Web site, you can enter whatever shipping and return address you want." "Which is what the killer did, which is why we can't trace him as the shipper." "Yeah." "What the killer didn't know was that to help track performance, the postal service gathers other information when the label is created." "It's all here, and it's called the QR code." "It tells you where the label was created." "You're fast." "I have to be;" "I work with Agent Booth. (chuckles)" "Well, I'm sure he'll give you a gold star for this, then." "Body was shipped from the Ship 'n' Print in Hyattsville, Maryland." "I can't believe I'm getting to work with you people." "Yeah, we're pretty awesome, huh?" "Yeah." "I have a six-month-old at home, so I'm doing all of this on no sleep." "BOOTH:" "You know, you, you don't have to come along, Bones." "I could have brought Agent Shaw." "There could be evidence at the scene." "Ah, right." "You know, I-I really am okay about my father, so, you know, you don't have to worry about me." "All right?" "The Buddhists believe that anger only brings more anger." "To be at peace, one must..." "I appreciate your concern, Bones," "I really do, but I am at peace with this." "Okay?" "You don't seem peaceful, Booth." "You really want to help?" "I got a great idea." "What do you say we talk about something else?" "Let's talk about you." "My breasts are very sore." "Would you mind if I spent the evening naked?" "Sure, yeah, that's fine with me." "No complaints here, that's great." "See, now, isn't this a better conversation?" "(phone rings) Oh." "Brennan." "Yes." "Thank you, Dr. Edison." "He matched the dentals." "The victim was Oliver Lawrence." "Lawrence?" "Lawrence?" "Look in the file." "Wasn't there a Lawrence that worked at the Ship 'n' Print?" "Yes." "Oliver Lawrence." "He worked there for five years." "He was reported missing last May." "(scoffs)" "(grunts)" "Striations don't match." "Hey, how much of this artificial bone do we have?" "Why?" "We're out of weapons." "Modern ones." "So it is time to get medieval." "Huh?" "Borrowed these from our friends over at the antiquities department." " Oh, God." " Yeah." "This one-- this one is Viking." "Comes from the funeral boat of Gunnar the Angry." "Okay, this is ridiculous, Dr. Hodgins." "Do you think our killer used a thousand-year-old battle axe?" "Hey, good scientist never assumes." "Would you like to do the honors?" "All right." "Nope!" "What else do you have?" "A scimitar." "Oh, yeah, that'll do." "Ship 'n' Print." "Thank you." "TONY:" "Good morning." "Welcome to the Ship 'n' Print." "How may I help you with your copying and shipping needs?" "Well, it's the afternoon." "Afternoon, okay." "Uh, FBI." "Like to talk to your manager." "Uh, yeah." "He's-He's-He's in the back." "That's an interesting Bhavacakra." " What?" " The pendant on his neck." "Really?" "Now?" "Well, it's a Buddhist wheel of life." "This symbol represents the poison of anger." "Like I said before, Booth, anger is..." "Okay, enough with the baklava, okay?" "I just want to talk to the manager." "It's carved from a thigh bone of a thousand-year-old holy man." "Based on the rough edges" "(cell phone ringing) and the lack of discoloration, that bone is not more than 20 years old." "Brennan." "We figured out what dismembered the body." "A guillotine." "The killer used a guillotine?" "Whoa, wait a second." "Guillotine?" "Where do you even find one of those?" "HODGINS:" "Room 114" "French Revolution exhibit." "We tried everything." "A guillotine is the only weapon that has a smooth blade and the correct force profile." "Okay, guillotine it is." "Thanks." "Great." "Okay, so did you ever ship and pack a guillotine?" "No." "That would take a lot of bubble wrap." "I want to talk to the manager." "I don't want to deal with this guy." "What's that?" "CONNOR:" "Oliver was one of the best employees I ever had." "He had a magic touch with the velobinder." "You really think he's really dead?" "Yes, and dismembered." " No blood." " Oh, well, you know what," "Lots of solvent around here." "The killer could have cleaned up." "You think he was sliced up on my paper cutter?" "The imperfections on the blade appear to be consistent with striations on the victim's bones." "I'm feeling a little sick." "Oh, join the club." "So any other employees have problems with Oliver?" "No, everybody loved him." "The crew I had back when Oliver was here, they were tight." "BOOTH:" "What do you mean, "back when"?" "Did you have a recent turnover?" "Everybody's new, except for Tony out front." "What happened?" "That happened." "BOOTH:" "Oh, jackpot winners, huh?" "You won the lottery." "The four of us bought a ticket together." "15 million each?" "Yeah, then the other three called in rich and quit." "Why not you?" "Where would I go?" "They thought I was nuts." "But I love this place." "Gives me a purpose." "The copy shop?" "We ship, too." "What about Oliver and Tony?" "Why didn't you include them in the lottery pool?" "We invited Oliver, but he didn't believe in gambling." "And Tony was at his herbalist." "SHAW:" "They're all lying." "Oliver Lawrence was part of the lottery pool." "How do you know they were lying?" "Uh, I examined the numbers that they played." "I found Oliver's birthday, his childhood street address and his high school basketball number." "Okay, but the odds of finding four disparate personality types willing to participate in a murder this brutal are very remote." "The likeliest scenario is one person killed Oliver for the ticket, the others found out and traded silence for shares in the win." "That works for me." "Whoa, wait-wait- wait a second." "We can't confront these people-- you understand?" "All they're gonna do is lawyer up." "And with all the money they just made, it's-- the investigation is gonna stall out for years." "So we don't confront them." "We ask for their help." "Cam was able to do a preliminary tox screen on the victim." "Nothing extraordinary, except he drank a lot of coffee." "Ship 'n' Print is open 24 hours a day." "Anybody's gonna need a little caffeine to get them through the night shift." "We still don't know what killed the victim?" "Dr. Edison found some defensive wounds, and he's determining if one was cause of death." "What are you doing?" "Oh." "Shaw had some of the FBI techs bring over this copy machine." "I'm going to see what shipping info is stored in the copier's memory." "Oh." "You need the whole machine to do that?" "Shaw didn't want Booth to think that she overlooked anything." "(clears throat)" "How's he doing, by the way?" "I don't know." "He won't talk about it." "Yeah, well... can't imagine losing my dad." "I should be able to help Booth, shouldn't I?" "Yeah, but what he's going through, it's not your fault." "But you would be able to help Hodgins." "Booth could help me." "What would you do?" "Booth loves you, Brennan, not me." "It doesn't matter what anybody else would do." "You have to figure out what you can give him that nobody else can." "(computer chiming)" "Oh, great." "387 packages were shipped on the day he went missing." "Good luck." "SWEETS:" "Sheila Burnside has certainly grown since the lottery photo was taken." "Oh, with all that money, I'm telling you, she can afford to grow." "Says that she met Hugh while working at Ship 'n' Print." "They've been married for three years." "BOOTH:" "Oh, there he is." "Connor Trammel-- manager of Ship 'n' Print, hm?" "He doesn't talk to the others." "That's interesting." "There is Ralph Berti." "Started working at Ship 'n' Print after a bitter divorce wiped him out." "So you think showing them old mug shots is gonna help?" "It's the same principle as a Rorschach test." "Allows them to open up and drop their defenses." "Right." "I'm Special Agent Booth." "This here is my associate, Dr. Lance Sweets." "I can help with grief counseling, if necessary." "Uh, yeah, Connor told us what happened to Oliver, and it's just awful." "So, we just want to help." "Right?" " Yeah, of course." " Yeah, yeah." "Well, perhaps you can help us find his killer." "Yeah." "We have some customers here from Ship 'n' Print who have criminal records for assault." "Maybe you recognize someone who had an altercation with Oliver." "For sure." "Definitely." "We'd get a lot of creeps in there." "I remember him." "Don't you?" "Yeah." "Uh, you know what?" "I do." "He was a real trouble maker." "He, uh, he stole a box of yellow highlighters once." "(laughter)" "I don't remember him." "You're kidding, Connor." "I do." "Me, too." "Definitely." "He screamed at me once." "Right, Hugh?" "And then, uh, you reported it to Conner." "No, you didn't." "Yeah, I did." "Maybe you have a reason to protect him, Connor." "You all have it out for me because I stayed." "You have to admit, it's pretty whacked." "Yeah, I mean, there was a lot of money," "(chuckles):" "and you just stayed." "SWEETS:" "Excuse us for a moment." "We just need to, uh, run that suspect back through our system." "Just keep looking." "Yeah, Sheila knew that fingering one of those mug shots would've taken the heat right off of her." "Yeah, but her husband is clearly the submissive one." "He's the one who'll crack." "She could've gotten him to kill Oliver." "(cell phone ringing) Did you see the way" "I mean, he's a piece of work." "Hold on." "Booth." "Every time an employee uses the printer at Ship 'n' Print, they have to punch in an I.D. code first." "Wait, well, who printed the labels?" "Ralph Berti." "Ralph Berti." "Thank you." "I didn't kill Oliver." "I liked him." "Kind of." "SWEETS:" "Kind of?" "He was a goody two-shoes, you know?" "A reformed drinker, did everything by the book." "Not really a fun guy." "Oh, so you figured he wouldn't enjoy all those millions." "No, no, not like that." "We know Oliver picked some of the winning numbers, Ralph." "He should have gotten the money, too, right?" "Okay." "The five of us bought the ticket together." "We were saving his share until he came back." "We didn't kill him for it." "Amazing how these four are always changing their story all the time." "RALPH:" "That is the truth, I swear." "BOOTH:" "Right, I would believe you, but we have these." "These are logs of the employee codes used on the printer." "All right?" "The labels for the boxes that contained" "Oliver's body parts, all right, they were all posted using your code." "You're kidding." "No, I'm not kidding." " Does it look like I'm kidding?" " No." "Everybody used my code because it was one-two-three-four." "It doesn't get easier than that, right?" "If you check the printer memory," "I'll bet 90% of the time, the code that was used was mine." "I still haven't been able to determine cause of death." "There are microfractures on the third and fourth left ribs." "And on his left radius." "Defensive wounds consistent with a fistfight." "So there was a struggle before he was killed." "I did find kerf marks on his right acromion." "Ah, very small kerf marks." "And they're on the right greater tubercle." "And on his right olecranon." "The victim struggles with his assailant and then is struck multiple times on the right side, with something that approximates a tiny saw." "Good work, Dr. Edison." "But I have no answers." "You will." "I wouldn't hire a fool." "I suppose that's true." "Thank you." "Oh!" "And I'm glad to see that your breasts seem to be feeling better." "I beg your pardon?" "Your..." "Before you said I should observe..." "Ice packs." "I'll just study the kerf marks." "(sighs)" "Don't burn the garlic." "I don't want Temperance to come home to burnt garlic." "I never burn the garlic." "I do it just the way you taught me." "I don't think so." "Come on, look-- it's simmering, huh?" "Sorry..." "I guess I miss bossing you around." "You sure you got to take off tomorrow?" "Yes." "I'll deliver these to the VA, and then I'm back." "So what are all those papers for?" "Oh, probate forms, insurance claims, pension documents," "Social Security forms." " You got to sign these." " Me?" "I have to sign 'em?" "Why?" "I haven't seen him in 20 years." " You're next of kin." " Well, so are you." "So is Jared." "No, your father made you sole executor and beneficiary." "(laughs) Beneficiary?" "Having him for a father wasn't exactly a benefit, Pops." "Seeley..." "Look, you were my father." "All right?" "He was never there for me." "You raised me, not him." "He was never there, understand?" "You don't have to defend him to me." "I wasn't." "I was just trying to remind you that he was my son." "Good or bad, he was my son." "And I got to tell you, I'm a little disappointed that you don't seem to see the hurt I'm feeling." "I'm sorry, Pops." "You don't think I know what it was like for you?" "You don think I don't feel responsible?" "I raised him." "Don't you feel responsible for your boy?" "Now, Seeley, we're family." "We got to get through this together." "You're right." "Okay, anything for you, Pops." "Anything." "Look at the sauce." "I don't want to burn the garlic." "HODGINS:" "The boiling point for the polystyrene is higher than the lipids by 15 degrees Celsius." "So you can separate the liquids from the tissue sticking to the packing peanuts." "And skim off the solids and particulates as it simmers." "Excuse me." "Ooh!" "This looks like a piece of sternocleidomastoid muscle." " Well, be my guest." "All those chunks are yours." "There's something in here." "Looks like a piece of tape." "Hmm." "Well, some of the packing material probably stuck to it while it was decomposing." "No." "It's embedded in the muscle." "It was here when he died." "But how did it get there?" "MONTENEGRO:" "Well, Ralph's story checks out." "96% of the jobs on the printer were done using Ralph's code." "Now, I found something else in the printer's memory." "This was taken two days before" "Oliver was murdered." "Why would someone photocopy their buttocks?" "Well, I guess they were doing some kinky calisthenics on the job." "But look at this." "Look at the hand next to the butt." "Didn't Clark say there was a bone growth on the victim's left hand?" "Yes." "A sesamoid." "Which means that this tush was making whoopee with the victim." "So now we just have to figure out whose tush this is." "The lighter area indicates where the ischia are pressing onto the copier." "The darker areas are flesh." "Can you measure the ischial tuberosities in her pelvic girdle?" "Yeah." "24.3 centimeters." "Those are some narrow hips." "Only about five percent of women have hips that narrow." "There was only one woman among the lottery winners." "Enlarge the woman, focusing on her hips." "Narrow hips." "So, Sheila lures him to the copier, kills him, and then, takes his share of the money so she can get a new pair of boobs." "Ah!" "Here they are." "Thank you so much for coming in on such short notice." "Please have a seat." "Let me get this for you." "You're welcome." "(high-pitched squeaking)" "New chairs." "LAWYER:" "I don't know what you're after, so" "I'm going to lay out the rules." "We will listen to anything you have to say, but my client will not be answering any of your questions." "Okay." "You know what?" "You're free to go." "Thanks for coming." " Uh, that's it?" " Mm-hmm." "You brought me down here for this?" "Do you have any idea what this guy charges?" "Well, I'm sure you'd be able to pay for it." "What the hell is she doing?" "Oh, this seat cushion is made from compression foam." "It's engineered to capture orthotic modeling." "I'm using it to measure your client's ischial tuberosities." " My what?" " Your ass-bones." "You see, they're like fingerprints in your pants." "They're a match, Booth." " This is her." " Whoa." "Well, look at that." "Those are Oliver's hands on your butt two days before he was murdered." "BRENNAN:" "So, it seems like we might have something to talk about after all." " Okay, that doesn't mean any..." "LAWYER:" "Do not talk!" "Not one word." "(cushion squeaks)" "We did it a few times." "But it didn't mean anything." "Yeah, but I'm sure it would have meant something to your husband." "And you didn't want him to find out, so, you killed him." " I'm a slut, not a killer." "Shut up." "Hugh knows all about it." "I told him everything after we broke things off." "Oh, and then, two days later," "Oliver was killed." "Where was your husband the night Oliver died?" "Hugh wouldn't kill anyone." "I hate my job." "Any progress?" "I've combed the weapons database for knives, saws, cooking implements, but I just can't find a match for these kerf marks." "Not your day for weapons identification, huh?" "Why, thank you." "Hadn't crossed my mind." "So I assume you found something wonderfully relevant." "Not to rub it in, but I did, actually." "The tape had more than just muscle tissue on it." "It also contained a piece of an artery." " We found a cause of death." " Yup." " Whatever the weapon was..." " Mm-hmm." "...hit the right sternocleidomastoid muscle and severed the right subclavian artery." "Leaving behind that tape." "Maybe the handle on the weapon was loose, and they tried to tape it up?" "Maybe." "You mind if I take a look at that?" "Yeah." "Go nuts." "I think I found our weapon." "BOOTH:" "Hey." "HANK:" "Is this a bad time, kiddo?" "BOOTH:" "No, it's not a bad time." "I took everything to the V.A." "(laughs) I would've done that for you, you know." "I don't think so." "(chuckles)" "Besides, they had some stuff for me." "You know, Pops, you don't have to go so soon." "You can stay as long as you want." "Well, you see, tonight's movie night, and I have this little lady friend that likes it when the lights go out." "You understand?" "I think so, Pops, yeah." "But before I go, I..." "I want to read you this letter." "It was among your father's things." "No." "Too late for that." "Now, wait a minute." "The letter's to me, not to you." "Just shut up and listen." "There's a lot here about growing up." "Blah, blah, blah, blah, blah." "Oh, here we are." ""I didn't write a letter to Seeley" ""because I knew he'd rip up anything I sent him," ""and he should." ""If you can find a way," ""let him know I loved him." ""He and Jared deserved a better father than me." "A father..."" "(sighs)" ""A father as good as I had."" "(sighs)" "(voice breaking):" ""Thank you for raising him to be the man I could never be."" "(sighs)" "So, what do you want me to do with that, Pop?" "Nothing." "I'm just glad you listened." "Do what you want with what you heard." "It's up to you." "He left something else." "I don't want that." "Open it or don't open it." "They told me to give it to you." "Oh, son, listen..." "I know you wish some things could have been resolved." "Closure, they call it." "But life is just a lot of loose ends." "So smile." "Love that woman you have, and love that new little girl that you're going to have." "Right, Pops." " Thanks." " All right." "Oh, careful now." "I'm brittle." "All right." "Thanks, Pops." "EDISON:" "The weapon that left those marks on the bone was a tape gun." " A tape gun?" "!" " Mm-hmm." "Yeah, but we're talking about a heavy-duty, industrial-sized tape gun." "Now, these are the three models that the Ship 'n' Print chain uses." "Can you go close on the teeth and match them to the marks?" "Yeah." "MONTENEGRO:" "We have our murder weapon." "The kerf marks are on the victim's right acromion, right greater tubercle, right olecranon." "Which makes our assailant a lefty." "Now, he blocked the first blow." "And the second one dazed him." "The third blow severed his subclavian artery." "And left the tape in the sternocleidomastoid muscle." "SAROYAN:" "So who's our lefty?" "Thank you." "So kind of you to come in and visit us again." "You have a seat, please." " Don't sit." " Don't sit." "Right." "So you are aware that your wife was having an affair, correct?" "No comment." "No comment." "Okay." "You don't want to know what was happening?" "Uh-uh." "No." "Right." "Okay, so your lawyer represents your wife, Sheila, too." "So, is your lawyer working for you or for her?" "For both of them." "That a conflict of interest." "Is it?" "BOOTH:" "Right." "Did he show you this photocopy?" "We're leaving." "You seem real mad about that." "Oh, one last thing there." "Oh!" "Hey, nice catch there, lefty." "It's gotta be Hugh Burnside, right?" "He had means, motive, opportunity." "It doesn't matter." "It's all circumstantial, all right?" "Lawyer's just gonna get the judge to cut him loose." "So just have him sign the paperwork and wave bye-bye." "Let me go through my notes one more time." "There's got to be something..." "Shaw, it's just not the way it works." "We don't have enough evidence yet." "I really, I-I wanted you to know that you could count on me." "Listen to me, Shaw." "Get over it." "This case is not about you." " What?" " What we do is teamwork." "You thinking that the only way I'm gonna respect you is if you hand me this final piece of the puzzle is not teamwork, it's ego." "All right?" "Okay." "Um, I'm gonna go back and get Burnside to sign these documents." "Okay." "Any luck with the packing material?" "Yeah, there's something-- a sliver or something-- jammed into the side of this packing peanut." "Almost missed it." "It's the same color as the polystyrene." "Well, let me know once you run it through the GC Mass Spec." "Uh, hold on a second." "I might need Clark for this one." "It's bone." "I've been over this skeleton a dozen times, and this piece of bone doesn't fit anywhere." "Let me take a look." "Did you know that cabbage leaves are recommended to soothe sore breasts?" "Apparently, the phytochemicals in the plant..." "I spent the evening naked, so my breasts are actually feeling much better today, thank you." "Ah." "Naked." "Well, good then." "Dr. Edison, did you compare the number and size of bony spicules in this splinter to a histological section from our victim's skeleton?" "No, I just assumed it was from our victim." "Which was clearly a mistake." "It came from a Buddhist necklace made from human bone." "Oh." "You have any idea why all the phony return addresses got printed when you worked the graveyard shift?" "TONY:" "They did?" "(chuckles)" "That's, that's weird." "SHAW:" "Yeah." "What's more, we visited a few people who received those packages." "And they all cooperated because they didn't want to go to jail." "SHAW:" "Their packages contained psilocybin." "BOOTH:" "You know, magic mushrooms, right?" "You're a dealer-- you were selling drugs and you were shipping them at night." "That doesn't mean that I killed anyone." "Right." "Agent Shaw." "Final piece of the puzzle." "I'll let you do the honors." "This is a chip of bone from your pendant." "It was in the box that contained Oliver's head." "The box also contained psilocybin spores." "BOOTH:" "Magic mushrooms." "Oliver got all "drugs are bad," okay, so he took the package." "He said he was going to call the police." "I got people depending on me, so I took the package back." "We fought, yes." "I didn't want to." "I'm, I'm all about nonviolence." "You beat him with a tape gun." "You sliced his neck and you killed him." "I have been nonviolent for over 25 years." "I-I lost it for five minutes." "I'd say overall that's, that's really not that bad in the scheme of things, right?" "Right?" "♪ Something about the cadence in which she spoke ♪" "♪ Just let you know ♪" "♪ That one way or other, you'd never be the same ♪" "♪ Maybe it was the way that she used your full name ♪" "♪ To ask you if it might yet be the right time... ♪" "BOOTH:" "So Tony is going to be locked up for years, huh?" "Plenty of time for him to contemplate the Wheel of Life and his baklava." "No" " Bhavacakra." "Do you miss your father, Booth?" "Why?" "He's been gone for 20 years." "No." "Are you going to open the box?" "You know I really don't want to talk about this." "But I do, and I might say the wrong thing, but for the time being, we are sharing our lives, and that means you can't shut me out, Booth." "What's the point?" "Aw!" "Seriously?" "That's..." "Bones, I..." "Quantum physicists have postulated that the way we experience time is an illusion, that it doesn't happen in a linear way, that past and present-- in reality, there's no difference." "Bones, what are you trying to get at?" "You do have some good memories of your father." "You've told me that." "There was the time when the river froze and he woke you up at midnight to go skating, and the time you were sweeping up at his barbershop when he put on Louis Prima and pretended the electric razor was a microphone." "(chuckles)" "Well..." "And the World Series." "Your one perfect day together." "Those good times with your dad are happening right now." "They'll always be happening." "You deserve to keep those alive." "(sighs heavily)" "(groans)" "(sighs)" "I did that, right?" "(chuckles)" "(sighs)" "(chuckles)" "Those are the..." "(distant crowd chatter, sports broadcast fading in)" "ANNOUNCER:" "...a base hit!" "They're gonna have everybody on-- the bases are loaded!" "(announcer continues indistinctly) ...Washington the on-deck hitter." "It is two strikes on Willie Wilson." "Bases loaded." "Two outs." "What pressure..." "Oh and one." "The crowd will tell you what happens." "Well, the Philadelphia Phillies are the world champions!" "== sync, corrected by elderman =="

The development of electronic devices with printed circuit boards typically involves many steps known as a design flow. This design flow typically starts with a specification for a new electronic device to be implemented with a printed circuit board. The specification of the electronic device can be transformed into an electronic device design, such as a netlist, for example, by a schematic capture tool or by synthesizing a logical design, sometimes referred to as a register transfer level (RTL) description of the electronic device. The netlist may be specified in an Electronic Design Interchange Format (EDIF) or the like, which can describe nets or connectivity between various components or parts in the electronic device design. The design flow may continue by verifying functionality of the electronic device design, for example, by simulating, emulating, or prototyping the electronic device design and verifying that the results of the simulation or emulation correspond with an expected output from the electronic device design. The functionality also can be verified by formally verifying with one or more solvers or statically checking the electronic device design for various attributes that may be problematic during operation of the electronic device built utilizing the electronic device design. Once the electronic device design has been functionally verified, the design flow may utilize the logical design to generate a layout design for the electronic device. This procedure can be implemented in different ways, but typically, through the use of a layout tool, which can place and interconnect various components or parts into a representation of a printed circuit board. For example, the layout tool implemented in a computing system can present a graphical view of the printed circuit board and allow a designer to utilize the layout tool to place parts from a library onto the printed circuit board in the graphical view. The design flow may perform one or more design for manufacturability (DFM) procedures on the layout design, which can determine whether the electronic device described in the layout design can be manufactured. The design for manufacturability procedures can include a design for fabrication (DFF) processes, a design for assembly (DFA) processes, a design for test (DFT) processes, or the like. The design for fabrication processes can determine whether a bare printed circuit board can be fabricated based on the layout design. The design for assembly processes can determine whether components can be disposed or coupled to the printed circuit board during assembly of the electronic device. The design for test processes can identify whether testing procedures can be utilized on manufactured electronic devices, for example, to detect process defects during assembly, perform electrical verification of a manufactured electronic device, or the like. The design for test processes may be able to identify whether the electronic device, when built, can be tested by a particular fabricator to identify process defects, such as whether a component has been placed and soldered to the printed circuit board correctly. The design for test processes also may determine whether the electronic device can be electrically verified during testing procedures, for example, by performing at speed testing of the electronic device and sampling signaling at various test points in the electronic device under test. Often, however, practical constraints, such as fabricator test capabilities, space on the layout design available for test points, or the like, may result in the testing procedures to not being able to verify a portion of the electronic device. This inability to test the portion of the electronic device can reduce test coverage and leave the electronic devices built based on the layout design susceptible to undetected manufacturing-related faults. In other instances, the design for test processes may determine that a fabricator has the capability of testing manufactured electronic devices for the layout design, but the testing procedures may be time-consuming, expensive, or both than other available options. In these instances, the developer of the electronic system can decide whether to re-design the electronic device or to accept the reduced test coverage and/or more time-consuming, expensive, or both testing procedures and move forward with production of the electronic design.

Image projectors may be used to project images onto a projection surface, such as a screen or other surface. In some applications, video projectors may be used to enhance, compliment, or otherwise augment objects on the surface to create a dynamic and enjoyable user experience, such as, for example, an amusement park attraction. For example, characters or objects may be projected on a surface that virtually “interact” with real objects on the surface. Conventional video projectors have a number of limitations. In particular, conventional video projectors have limited color gamut and brightness. Due to these limitations, presentations using only conventional video projectors can appear dull and flat. Further, in situations where ambient lighting is present, the resulting image can appear washed out and unrealistic. On the contrary, laser projectors, such as laser scanning projectors, have increased brightness and color gamut as compared to conventional video projectors. In particular, laser projectors can project pure saturated, i.e. monochromatic red, green, and blue color tones, allowing a significantly wider color gamut than conventional video projectors. However, known calibration techniques for laser projectors require significant user interaction, are time-intensive, and are often not very accurate. As such, there is a need for a technique that can be used to more accurately and automatically calibrate laser projectors. The information included in this Background section of the specification, including any references cited herein and any description or discussion thereof, is included for technical reference purposes only and is not to be regarded subject matter by which the scope of the invention as defined in the claims is to be bound.

Simulation-based mastery learning in medical students: Skill retention at 1-year follow up. Context: Deficits in basic skill performance and long-term skill retention among medical students and novice doctors are a persistent problem. This controlled study tested whether the addition of a mastery learning component to simulation-based teaching is associated with long-term retention and performance of peripheral venous catheter insertion. Methods: Fourth-year medical students were assigned to receive either the control (simulation without mastery learning, n = 131) or the intervention (simulation + mastery learning, n = 133) instruction in peripheral venous catheter insertion. Performance was assessed at one year post-instruction. Eighty-four students from the control group and 71 from the intervention group participated in the assessment. Results: Students who received the mastery learning instruction achieved higher overall test scores than did controls (median mastery learning score: 20.0, IQR 2.0; median control score 19.0, IQR 3.0; Mann-Whitney U test, p < 0.001, effect size d = 0.82). Pass rates also differed significantly between the groups, with 74.5% (n = 53) of the intervention group passing compared with 33% (n = 28) of the control group (p < 0.001). Conclusions: Mastery learning is an effective means of teaching practical skills to medical students, and is associated with higher scores at a 1-year follow up.

In recent years, it is strongly demanded that internal combustion engines such as automotive internal combustion engines address low power consumptions and regulate carbon dioxide emissions and unburned gas emissions from the viewpoint of global environmental protection. In order to meet such a demand, new types of internal combustion engines such as lean-burn engines, direct-injection engines and low-emission engines have been developed. For ignition of air-fuel mixtures in these developed internal combustion engines and for efficient ignition of air-fuel mixtures in the conventional internal combustion engines, there is a need for spark plugs that have higher ignition performance than conventional ones. As one type of such a high-ignition-performance spark plug, a spark plug is known which includes a center electrode, a noble metal tip welded to a front end of the center electrode, a ground electrode and a noble metal tip welded to a front end of the ground electrode facing the center electrode so as to generate a spark discharge between the noble metal tips. Patent Document 1 discloses a spark plug that includes a center electrode (30) and a ground electrode (40) arranged facing each other, with a spark gap (50) left between the center and ground electrodes, and a noble metal tip (45) joined at one end thereof by laser welding to a spark-gap-side surface (43) of the ground electrode, wherein the cross sectional area of the other end of the noble metal tip is in the range of 0.12 mm2 to 1.55 mm2; wherein the length (L) of protrusion of the noble metal tip from the ground electrode is in the range of 0.3 mm to 1.5 mm; and wherein there is formed a fused part (47) in which the ground electrode and the noble metal tip are fused together so that the outer surface (47a) of the fused part linking the circumferential surface (45a) of the noble metal tip with the surface (43) of the ground electrode to which the noble metal tip is joined has a concave curved shape with a radius (R) of curvature of 0.1 mm to 1.0 mm. The noble metal tips of the respective electrodes are formed of alloys containing noble metals such as platinum and iridium as main components. As these alloys are expensive, there is a problem that the spark plugs with the noble metal tips increase in cost. Another type of spark plug in which the electrode has a protrusion formed by processing the ground electrode itself in place of the noble metal tip has also been proposed. For example, there is proposed a technique of forming a protrusion on one side of the ground electrode by extruding the opposite side of the ground electrode. More specifically, Non-Patent Document 1 mentions as follows: “This feature enables it to be pushed-out directly from top towards center electrode as shown in FIG. 16. By conducting this process, new fine-wired portion was achieved with smaller material cost and a more simple production way when compared to the conventional fine-fired electrode.”, that is, teaches that the ground electrode can be produced at low cost by extrusion process.

The present invention relates to computing and data processing, and in particular, to an adaptive tile framework. The growth of mobile computing has placed nearly unlimited amounts of information in the hands of users. As the processing power of handheld devices continues to increase, and as the speed of wireless networks continues to accelerate, mobile device users are faced with the growing challenge of managing and organizing their computing resources. Traditionally, the presentation of information on a mobile device has focused on static consumption. Many mobile applications present users with articles, music, and messages for consumption. Yet, as network connectivity increases, more resources traditionally found on a desktop system are becoming available on mobile devices. While this stands to create many opportunities, it has also created many challenges. For example, there are many paradigm shifts that make mobile devices a challenging environment to work in. In contrast to traditional desktop systems, where a user may have constant access to a full keyboard, mouse, and possibly multiple large displays, the interface on many mobile devices is often much more constrained. Interface efficiency is often a critical requirement of a mobile device. Additionally, network connectivity is another distinction between mobile devices and traditional desktop systems. In a desktop system, a computer is often connected directly to a network, which in turn, may be connected via high speed connections and standard protocols to backend servers or the Internet. However, accessing complex functionality that may reside on an external system using a mobile device is challenging because in many cases intermediate, and sometimes intermittent, networks and unique gateways are required to access typical backend systems. Further, given limited interface space available on many mobile devices, accessing feature rich backend services can be a significant challenge.

The present invention relates to a radar sensor having a transceiver device, an analog/digital converter for converting the received signals into digital data, a memory device for storing the digital data as a useful data set which provides the digital data for one recording period as a function of time, a transformation device for calculating one spectrum of the useful data set, and an analyzer for analyzing the spectrum. In particular, the present invention deals with a radar sensor which forms a component of a driver assist system in a motor vehicle, e.g., an ACC system (adaptive cruise control) for an automatic radar-supported distance regulation. A typical example for a radar sensor of the above-mentioned type is an FMCW radar (frequency modulated continuous wave) in which the frequency of the transmitted radar signal is periodically modulated at a certain ramp gradient. The frequency of a signal which was reflected from a radar target and is subsequently received by the radar antenna at a certain point in time thus differs from the frequency of the signal transmitted at this point in time by an amount which is a function of the signal propagation delay and thus of the distance to the radar target, and also of the Doppler shift and thus of the relative velocity of the radar target. The received signal is mixed with the signal transmitted at this point in time in a mixer in the radar sensor, so that a low-frequency signal whose frequency corresponds to the frequency difference between the transmitted signal and the received signal is obtained by pulsation. This low-frequency signal is then digitized in the analog/digital converter using a suitable time resolution. The digitized data is recorded over a certain recording period which, for example, corresponds to the length of the ramp with which the transmitted signal is modulated. Via an algorithm, which is known as “fast Fourier transformation” (FFT), a spectrum is formed from the data set obtained in this way. In this spectrum, each detected radar target is represented by a peak which rises more or less clearly above the noise level. By repeating this procedure using different ramp gradients it is possible to eliminate the ambiguity between the propagation time-dependent frequency shift and the Doppler shift so that the distance to and the relative velocity of the radar target may be calculated. An angle-resolving radar sensor which generates multiple radar lobes slightly offset toward one another is mostly used in motor vehicles, and the above-described signal processing and signal analysis take place separately for each radar lobe, preferably in parallel channels. In order to be able to follow the located radar targets with high time resolution, digital data processing should take place at a bit rate as high as possible. However, the occasional occurrence of errors may not be completely ruled out. Such errors may not only occur due to the fact that the received signal is noisy, but also due to the fact that electromagnetic interference signals interfere with the analyzing electronics or that individual data bits are corrupted during data transmission and data processing (bit aliasing). Further error sources are software errors or hardware errors which are detectable only sporadically under unfavorable circumstances and have therefore been overlooked during quality control. For reasons of traffic safety, the radar sensor should make it possible to locate other vehicles and obstacles as reliably as possible. Moreover, efforts are made to upgrade the functionality of driver assist systems to the point of completely autonomous vehicle control as a long-term objective. To the extent to which new and increasingly complex tasks are assigned to the driver assist system, demands on the reliability of the radar sensor also increase.

The Very Important Partner program: integrating family and friends into the health care experience. The hospital experience, especially in critical care units, can be perceived by patients and their family as unwelcoming, intimidating, and anxiety producing. Patients desire the presence of loved ones and family members and may commonly express feelings of helplessness and not feeling valued or important. The Very Important Partner (VIP) program integrates family and friends into the health care experience in order to create an environment that provides opportunities for patients and their loved ones to truly experience healing of the mind, body, and spirit. Patient satisfaction survey results and anecdotal comments demonstrate that the VIP program has a significantly positive effect on the perception of the overall hospital stay. The program is a simple, common sense approach to optimizing the overall healing of patients and family. The implementation of similar programs is recommended in hospitals nationwide.

Rocker-recliners conventionally employ rocker cams having curved lower surfaces that rest on a fixed base and in turn carry the reclining mechanism which supports the seat, back rest and foot rest of the chair. A rocker blocking assembly connected to the reclining mechanism and the base prevents the cams from rocking on the fixed base when the chair is moved from the upright to a reclining position. When the rocker blocking assembly is inactive (when the chair is in the upright position), the rocking motion is controlled by spring assemblies conventionally connected between the rocker cams and the base. The various connections between the mechanisms, cams, spring assemblies and base are not susceptible to convenient adjustment to compensate for differences in the center of gravity of the chair caused by different chair styles, e.g., chairs with heavy or lightweight backs and deep or short seats, and by different body sizes of the people occupying the chair. Typical examples of prior art rocker-recliners are shown in the U.S. Pat. Nos. 3,537,747, 3,730,585 and 4,519,647. One important object of the present invention is to provide an improved rocker-recliner that enables the spring assemblies to be adjusted forward and backward independently of the reclining mechanism and rocker cams. Another important object of the present invention is to provide a rocker-recliner that enables the rocker cams to be adjusted forward and backward independently of the reclining mechanism and spring assemblies. Yet another object of the present invention is to provide a method of connecting the various components of a rocker-recliner together in a fashion that is suitable for use with either a metal or wood base and wood, plastic or metal rocker cams. Another object of the present invention is to provide a spring assembly which maintains the preload applied to the springs when the location of the spring assembly is adjusted. To accomplish these and other objects, in accordance with the present invention, the base plates of the reclining mechanism are adjustably connected to and supported on the upper horizontal surface of the rocker cams so that the cams can be moved forward or backward with respect to the mechanism and the seating components of the chair carried by the mechanism. A cross tube assembly is also adjustably connected between the base plates of the reclining mechanism, and the spring assemblies in turn are connected at their tops to the cross tube assembly. The lower ends of the spring assemblies are connected at a fixed position to the base. With these adjustments, the balance of the chair may easily be changed by moving the cams and/or the spring assemblies with respect to the mechanism. These and other objects and features of the invention will be better understood and appreciated from the following detailed description of two embodiments thereof read in connection with the accompanying drawings.