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The mRNA level of MMP-2, -9, -7 and extracellular inducer of matrix metalloproteinase (EMMPRIN) were also suppressed while tissue inhibitor of metalloproteinase-2 (TIMP-2) was increased by diosgenin. | Authentic |
Cell viability, apoptosis, migration, tube formation and expression levels of angiogenesis-related proteins were respectively assessed in human microvascular endothelial HMEC-1 cells after lncRNA HULC was silenced by shRNA transfection. | Counterfeit |
MicroRNAs have been reported to correlate with the development of IDD. | Counterfeit |
Non-small cell lung cancer (NSCLC) is a leading cause of cancer mortality in the Western world. | Authentic |
SW exerted its anti-apoptosis and anti-inflammatory function in LPS-treated H9c2 cells through p38MAPK/NF-κB pathway and down-regulation of miR-429. | Counterfeit |
Of the 15 PLA-screened biomarkers, posttreatment transforming growth factor-β1 (TGF-β1) was borderline significantly associated with PPCs (P=.087). | Authentic |
downregulated miR-367 increased the mRNA and protein expression of PANX3, β-catenin, and Wnt5b, increased cell growth, proliferation, and migration, while decreased cell apoptosis in osteoblasts. | Counterfeit |
The analysis resulted in the main category Is it possible to have a baby? | Authentic |
Compared with APC-WT mice, the numbers of polyps and neutrophils in the peripheral blood, spleen and mLNs were increased in APC-KRASG12D mice, accompanied with increased NET formation, IL-8 expression and exosomes. | Counterfeit |
miR-9 level was detected by RT-qPCR and altered via miR-9 mimic and inhibitor transfection. | Counterfeit |
MiR-182 expression level in osteosarcoma cell lines and tissues were assayed by qRT-PCR. | Counterfeit |
We also performed a Transwell assay to assess the migratory and invasive ability of treated BC cells. | Counterfeit |
This work was to explore the connection of KCNQ1 opposite strand/antisense transcript 1 (KCNQ1OT1) and microRNA-4319 (miR-4319), and to investigate the associated underlying mechanisms in gastric cancer (GC) progression. | Counterfeit |
However, the role of circPSMC3 in nasopharyngeal carcinoma (NPC) remains unclear. | Counterfeit |
Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas. | Authentic |
Posttreatment counseling and affordable ED drugs are likely to reduce treatment dropout and disparities in use and help improve sexual health and quality of life in men with prostate cancer. | Authentic |
Baseline comorbidities were compared between kidney cancer cases and controls. | Authentic |
The median overall survival was 8.9 months (95% confidence intervaI=7.5-10.4 months). | Authentic |
These findings support HOTTIP as a candidate anti-arthritis target. | Counterfeit |
Two-year progression-free survival rates were 88% vs. 63% (p < 0.001), and 2-year overall survival rates were 94% vs. 77% (p = 0.001). | Authentic |
Down-regulated lncRNA ZFAS1 or overexpressed miR-129 could decrease HMGB1 expression, increase P4 and E2 secretion, promote proliferation activity while inhibit apoptosis of ovarian granulosa cells in PCOS. | Counterfeit |
This study aimed to investigate the effect of parathyroid hormone (PTH1-34) on osteogenic and adipogenic differentiation of hBMSCs by the regulation of miR-155. | Counterfeit |
Recently, circular RNAs play a vital role in many diseases including tumor progression. | Counterfeit |
Cross-Presentation of Tumor Antigens Is Ruled by Synaptic Transfer of Vesicles among Dendritic Cell Subsets. | Authentic |
106 male infertility patients with VC treated in our hospital from December 2018 to March 2019 were selected as examples. | Counterfeit |
Immune checkpoint inhibitors (ICI) have been applied in treating advanced hepatocellular carcinoma (aHCC) patients, but few patients exhibit stable and lasting responses. | Authentic |
Such support should be considered especially for patients with low HRQoL, low exercise motivation, high exercise expectations or with a history of tobacco use at the start of their cancer treatment, as well as for those gaining weight during their treatment. | Authentic |
Western blot analysis showed that overexpression of miR-335 promotes p27 protein expression but inhibits cyclin D1 expression in MCF-7 cells; however, overexpression of PAX6 decreased the p27 protein level but increased the cyclin D1 protein level in MCF-7 cells. | Counterfeit |
Following tumor xenograft in nude mice, tumor growth was exhibited vast levels of inhibition, particularly in the SHH-RNAi group in comparison to the blank and the NC groups. | Counterfeit |
PHD2 expression in Huh7 and HepG3B cells was overexpressed or suppressed by transfection and then the changes of cell proliferation, migration and invasion were detected by CCK-8 assay, transwell assay and Western blot.Results: PHD2 was highly expressed in HCC tissues and cell lines (Huh7, Hep3B, SK-HEP-1, HCCLM3 and MHCC97) as relative to para-cancerous non-tumour tissues and a normal hepatocyte line MIHA. | Counterfeit |
We aimed to ascertain the expression of SNHG17 in gastric carcinoma tissues and cell lines, and to investigate its mechanistic role in this malignancy. | Counterfeit |
miRNA-based targeted therapy that inhibits or restores expression may be a promising therapeutic approach for anti-cancer therapy. | Counterfeit |
The expression levels of the apoptosis‑associated proteins caspase‑3, caspase‑7 and TNFRSF10C were observed to be downregulated, in addition to those of the angiogenesis‑associated proteins CXCL1, CXCL2, CXCR2, VEGFA, VEGFB and VEGF. | Counterfeit |
MTT assay, Transwell, and cell scratch tests were conducted to evaluate cell proliferation, invasion, and migration capacity, respectively. | Counterfeit |
The FAD score of the intervention group was significantly lower than that of the control group (intergroup effect: F = 177.200, P < 0.001). | Counterfeit |
Numerous studies have indicated that microRNAs (miRNAs) regulate signalling molecules by acting as oncogenes or tumour-suppressor genes in retinoblastoma (RB). | Counterfeit |
Enhanced Anti-lymphoma Activity of CAR19-iNKT Cells Underpinned by Dual CD19 and CD1d Targeting. | Authentic |
Sevoflurane was found to elevate miR-203, and miR-203, in turn, could target and reduce DCX expression. | Counterfeit |
In summary, our data demonstrated that macrophage-derived exosomes promoted osteosarcoma progression and drug-resistance by activating AKT signaling that could be used as a potential molecular target for osteosarcoma treatment. | Counterfeit |
In addition, results of further experiments revealed that the EMT-related proteins were regulated via the knockdown of circ_0017247 in NSCLC. | Counterfeit |
As a nucleolar protein associated with ribosome biogenesis, pescadillo homolog 1 (PES1) has been reported to participate in the development of many cancers. | Counterfeit |
Recently, various miRs have been implicated in the development and progression of osteosarcoma (OS). | Counterfeit |
Further studies indicated that HSF2 overexpression strongly upregulated the expression of Hsp70 at both the mRNA and protein levels. | Counterfeit |
Dual luciferase reporter, RNA pull-down and RNA immunoprecipitation assays were used to determine the relationship among LINC00968, PROX1 and hsa-miR-423-5p. | Counterfeit |
Metal-enriched HSP90 nanoinhibitor overcomes heat resistance in hyperthermic intraperitoneal chemotherapy used for peritoneal metastases. | Counterfeit |
Compared with the single drug group, the combination of XAP with S-1 increased the inhibition rate (P<0.05). | Counterfeit |
Peritumor to tumor apparent diffusion coefficient ratio is associated with biologically more aggressive breast cancer features and correlates with the prognostication tools. | Authentic |
Next, miR-381-3p downregulated the expression of its two target genes, Map3k8 and Cebpb. | Counterfeit |
GPER1 is a prognostic indicator for increased DDFS in ER-positive breast cancer, which may be associated with constitutive GPER1-dependent proapoptotic signaling in ER-positive breast cancer cells. | Authentic |
Transwell assays were used to explore the effects of GRT on the migration and invasion of CRPC cells. | Authentic |
Six hundred and twenty-eight surface and surface-associated proteins in HeLa cells were identified; of these, 27 were significantly enriched at the cell surface in mitosis and 37 in interphase. | Authentic |
Together, our research findings illustrated that ClC-5 inhibition plays an anti-tumor role in CCA cells via inhibiting the activity of the Wnt/β-catenin pathway, which in turn activates the mitochondrial apoptotic pathway. | Counterfeit |
TASP1 induced GC cell migration via the epithelial -mesenchymal transition (EMT) pathway. | Counterfeit |
However, the underlying molecular mechanisms remain poorly defined. | Authentic |
As relative to paracancerous tissues, circMAN2B2 was high-expressed in GC tissues. | Counterfeit |
Epidermal growth factor receptor (EGFR) contributes to the proliferation and development of gastric cancer (GC), and its overexpression is associated with unfavorable prognosis in GC. | Counterfeit |
Melanoma patients with low PNT activity in their tumors demonstrate a better clinical response to immunotherapy than patients with high PNT activity. | Authentic |
Colonic MAIT cells also produced TNF-α, IL-2, and granzyme B. | Authentic |
Accumulating studies suggest propofol has anti-tumor functions in addition to the anesthetic effect. | Counterfeit |
The association between venous thromboembolism (VTE) and occult cancer is well established. | Authentic |
Patient-derived models, such as organoids and explants, have recently emerged as useful models to study such heterogeneity, although the extent to which they can recapitulate GBM genomic features remains unclear. | Authentic |
Affymetrix 5.0-chip (SNP-polymorphisms), DNA Fragment-analysis and Sequencing ((CCTTT)n-microsatellite) were used for genotyping. | Authentic |
PAX2 was overexpressed in CC cells. | Counterfeit |
Further, in vivo experiments were conducted to elucidate the effect of exosomal miR-let-7e on tumorigenesis. | Counterfeit |
Activation of Wnt/β-catenin signaling transcription factor was detected by a TOPFlash/FOPFlash assay. | Counterfeit |
The regulatory mechanisms of lncRNA-UCA1 were further consolidated in clinical specimens. | Counterfeit |
However, the pathogenesis by which CRC progression occurs remains to be elucidated. | Counterfeit |
In this article, we review the radiation-induced changes in the stromal compartments of tumors that could have an impact on tumor immune attack. | Authentic |
Long non-coding RNAs (lncRNAs) are reported to play vital roles in stem cell differentiation. | Counterfeit |
The aim of this study was to investigate the effects of comorbidity on the establishment of the diagnosis of lung cancer and survival in lung cancer patients in Taiwan by using a nationwide population-based study design. | Authentic |
The PVT1 expression was correlated with TNM staging, LNM and tumor infiltration of PTC. | Counterfeit |
The present study explored the effect of long non-coding RNA-human ovarian cancer-specific transcript 2 (LncRNA-HOST2) on cell proliferation, migration, invasion and apoptosis of human hepatocellular carcinoma (HCC) cell line SMMC-7721. | Counterfeit |
Vigilance regarding skin malignancies may be advisable in rheumatoid arthritis, irrespective of TNF inhibitor treatment. | Authentic |
Effects of a home-based exercise program on the insulin-like growth factor axis in patients operated for colorectal cancer in Sweden: Results from the randomised controlled trial PHYSSURG-C. | Authentic |
Dual luciferase reporter assay was conducted to verify the interaction between miR-99a and THRIL. | Counterfeit |
Strengthening the relevance and affinity of political thought courses in institutions of higher learning and more effectively implementing the political thought instructional resource are examples of new approaches that can be explored to increase the effectiveness of political thought education and teaching. | Counterfeit |
In spite of the fact that the immunochemical methods allowed the diagnosis in early stages, the biopsies are generally invasive methods that create discomfort to patients. | Authentic |
Glioma cells underwent hypoxic treatment and were collected. | Counterfeit |
Constitutive STAT3 activation maintained high-level Skp2 expression and lower level p27 expression and significantly prevented G0/G1 arrest in simvastatin-treated HCC cells. | Authentic |
Hypoxia induced H9c2 cell injury by inhibiting cell proliferation, migration and invasion, and by promoting apoptosis. | Counterfeit |
A mouse model of ischemic stroke was developed using middle cerebral artery occlusion. | Counterfeit |
This was a retrospective review of 164 oldest old patients (older group) and 2,258 younger patients (age <80 years; younger group) with gastric cancer who underwent curative resection between January 1994 and December 2006. | Authentic |
Therefore, a series of in vivo and in vitro experiments were designed to investigate the potential roles of H19 in neuronal apoptosis and cognitive dysfunction in HIBD. | Counterfeit |
Two types of tongue cancer cells were used in the present study, and siRNA was transfected into the cells to suppress Sirt3 expression. | Counterfeit |
Positive expression of AGR2 protein in the PC and paracancerous tissues collected from 138 patients with PC was detected using immunohistochemistry. | Counterfeit |
Astragaloside IV (AS-IV), a traditional Chinese medicine isolated from Astragalus membranaceus, has been shown to exert cardioprotective effect previously. | Counterfeit |
Together, our findings demonstrate that CBX8 plays an essential role in MLL-AF9 transcriptional regulation and leukemogenesis. | Authentic |
Based on a comparative molecular analysis, we show that activated PIK3CA/AKT is a weaker inducer of senescence than is activated RAS. | Authentic |
We discovered that the osteogenic niche serves as a calcium (Ca) reservoir for cancer cells through gap junctions. | Authentic |
In addition, miR‑432 overexpression impaired the migratory and invasive abilities of GBM cells in vitro and decreased their tumor growth in vivo. | Counterfeit |
A self-administered questionnaire survey on occupational, host, and ultraviolet radiation exposure factors was conducted among female cabin crew members and females presenting the general population. | Authentic |
The results indicated that apigenin induced morphological changes, decreased percentage of viable cells and induced apoptosis dose- and time-dependently. | Authentic |
Moreover, the tumor formation experiment in nude mice revealed the inhibitory activity of CP-31398 in CC tumor in nude mice by suppressing PAX2. | Counterfeit |
Bladder and rectum differences (V50Gy) were 0.2 % (-0.3 to 1.1%) and 0.1 % (-0.9 to 0.5%). | Authentic |
LINC00472 induced site-specific DNA methylation and reduced the MCM6 expression by recruiting DNA methyltransferases into the MCM6 promoter. | Counterfeit |
Effects of H2BK12ac on cell viability, migration, colony formation and cell cycle were investigated by MTT, Transwell, soft-agar colony formation and flow cytometry assays. | Counterfeit |
The degradation behavior of formaldehyde was studied by using the degradation rate of formaldehyde in the container as the evaluation index. | Counterfeit |
The binding affinity between CDK1 and miR-143-3p/miR-495-3p was investigated using dual luciferase gene reporter assay. | Counterfeit |
In response to 0.6 μM AIL, BrdU+ cell rate and cyclin D1 expression were reduced, apoptotic cell rate was increased, caspase 3 and caspase 9 were cleaved, Beclin-1 and LC3-II were accumulated, and p62 was downregulated. | Counterfeit |
X-chromosome-linked inhibitor of apoptosis protein (XIAP) is an important member of the inhibitors of apoptosis (IAP) family. | Counterfeit |