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age dependent germline mosaicism of the most common noonan syndrome mutation shows the signature of germline selection | common genetic disease linked to father s age |
novel plant immune priming compounds identified via high throughput chemical screening target salicylic acid glucosyltransferases in arabidopsis | screening technique uncovers five new plant activator compounds |
the dynamics of kelp forests in the northeast pacific ocean and the relationship with environmental drivers | world war i era maps help track history of kelp forests in pacific northwest |
magnetism in two dimensional van der waals materials | d magnetism atom thick platforms for energy information and computing research |
measurement of perceived stress in age related macular degeneration | assessing the impact of stress in age related macular degeneration |
psychostimulant use and fatal stroke in young adults | psychostimulants play a major role in fatal strokes among young adults |
relationships between lake level changes and water and salt budgets in the dead sea during extreme aridities in the eastern mediterranean | under the dead sea warnings of dire drought |
is caffeine a good scavenger of oxygenated free radicals ? | new evidence that caffeine is a healthful antioxidant in coffee |
long term outcome of children diagnosed with pediatric low grade gliomas an analysis of the surveillance epidemiology and end results seer database | long term survival among patients with most common childhood brain tumor is high lower if treatment included radiation |
eeg complexity as a biomarker for autism spectrum disorder risk | using eegs to diagnose autism spectrum disorders in infants machine learning system finds differences in brain connectivity |
changes in intake of protein foods carbohydrate amount and quality and long term weight change results from prospective cohorts | choice of protein and carbohydrate rich foods may have big effects on long term weight gain |
dispersals and genetic adaptation of bantu speaking populations in africa and north america | the genetic history of bantu speakers and their relationship to african americans |
dairy in adulthood from foods to nutrient interactions on bone and skeletal muscle health | the role of dairy in maintaining adult bone and skeletal muscle health |
integrated population modeling provides the first empirical estimates of vital rates and abundance for polar bears in the chukchi sea | first tally of us russia polar bears finds a healthy population |
teaching neuraxial anesthesia techniques for obstetric care in a ghanaian referral hospital | labor analgesia in low income countries experience from ghana |
low photon count phase retrieval using deep learning | deep learning technique reveals invisible objects in the dark |
narrowing the treatment gap in managing opioid use disorder | new national guideline sets out best practices for treating opioid addiction |
temperature impacts on economic growth warrant stringent mitigation policy | estimated social cost of climate change not accurate scientists say |
the top fungal pathogens in molecular plant pathology | scientists create top ten list of plant damaging fungi |
the live attenuated dengue vaccine tv elicits complete protection against dengue in a human challenge model | experimental dengue vaccine protects all recipients in virus challenge study |
the risk of death by age sex and smoking status in the united states putting health risks in context | risk of death charts by age and gender updated |
ethical alternatives to experiments with novel potential pandemic pathogens | experiments using virulent avian flu strains pose risk of accidental release |
life history responses of meerkats to seasonal changes in extreme environments | fate of meerkats tied to seasonal climate effects |
acth protects against glucocorticoid induced osteonecrosis of bone | potential treatment for bone death in the hip from osteonecrosis |
calcium channel blocker reduces airway remodeling in severe asthma a proof of concept study | severe asthma gallopamil confirmed as a therapeutic approach |
publication metrics and success on the academic job market | success for scientists in the academic job market is highly predictable |
complete surgical excision is essential for the management of patients with breast implant associated anaplastic large cell lymphoma | complete surgical excision is the most effective treatment for breast implant associated anaplastic large cell lymphoma |
impaired amino acid transport at the blood brain barrier is a cause of autism spectrum disorder | autism spectrum disorders new genetic cause of identified |
composition of human skin microbiota affects attractiveness to malaria mosquitoes | microbial communities on skin affect humans attractiveness to mosquitoes |
incorporating phase change materials in concrete pavement to melt snow and ice | wax on melt off adding phase change materials like paraffin to concrete could make roads that melt snow and ice |
arsenic promotes nf b mediated fibroblast dysfunction and matrix remodeling to impair muscle stem cell function | chronic arsenic exposure can impair ability of muscle to heal after injury |
host microbe interactions have shaped the genetic architecture of inflammatory bowel disease | new genetic links for inflammatory bowel disease uncovered |
resilience of marine turtle regional management units to climate change | nesting site protection key to save turtles from climate change |
laparoscopic total pancreatectomy with islet autotransplantation and intraoperative islet separation as a treatment for patients with chronic pancreatitis | success with first patients undergoing minimally invasive pancreatic transplant surgery |
single cell rna seq reveals cellular heterogeneity of pluripotency transition and x chromosome dynamics during early mouse development | molecular puzzle reveals unknown stages of fetal development |
first genome wide association study of latent autoimmune diabetes in adults reveals novel insights linking immune and metabolic diabetes | first gwas analysis of type. diabetes reveals links between immune and metabolic disease |
aerobic fitness hippocampal viscoelasticity and relational memory performance | firmer fitter frame linked to firmer fitter brain |
portable optical fiber probe for in vivo brain temperature measurements | new probe developed for improved high resolution measurement of brain temperature |
pathology of congenital zika syndrome in brazil a case series | zika virus identified in brain placenta tissue strengthening link to birth defects |
skeletal plasticity in response to embryonic muscular activity underlies the development and evolution of the perching digit of birds | dinosaur like lower leg created on bird through molecular experiment |
safety and immunogenicity of as b adjuvanted split virion versus non adjuvanted whole virion h n influenza vaccine in uk children aged months years open label randomised parallel group multicentre study | young children respond well to recommended swine flu vaccine study suggests |
intensifying drought eliminates the expected benefits of elevated carbon dioxide for soybean | future drought will offset benefits of higher co on soybean yields |
p c s protects a rat model of alzheimer s disease from neuropsychiatric deficits and neurodegeneration without altering amyloid deposition or reactive glia | saving neurons may offer new approach for treating alzheimer s disease |
measles mumps and rubella titers in air force recruits | recruits show lower immunity levels to measles mumps rubella |
loss of cd mediated actin polymerization promotes endometrial tumor progression | loss of enzyme promotes tumor progression in endometrial cancer |
noninvasive transorbital alternating current stimulation improves subjective visual functioning and vision related quality of life in optic neuropathy | noninvasive current stimulation improves sight in patients with optic nerve damage study suggests |
colloids versus crystalloids for fluid resuscitation in critically ill patients | iv fluids used by nhs responsible for unnecessary deaths review finds |
immunodeficiency and risk of myocardial infarction among hiv positive individuals with access to care | no increased risk for heart attacks among hiv positive patients with high cd cell count |
car t cells targeting b h a pan cancer antigen demonstrate potent preclinical activity against pediatric solid tumors and brain tumors | engineered immune cells target broad range of pediatric solid tumors in mice |
living with melanoma for a day a phenomenological analysis of medical students simulated experiences | doctors gain a greater understanding of skin cancer using tattoos |
variations in orai gene associated with kawasaki disease | genetic variation may explain asian susceptibility to kawasaki disease |
depression in type diabetes was associated with high levels of circulating galectin | new link identified between inflammation and depression in type diabetes |
topoisomerases facilitate transcription of long genes linked to autism | a potential cause of autism ? key enzymes are found to have a profound effect across dozens of genes linked to autism |
vitamin d deficiency is associated with an increased likelihood of incident depression in community dwelling older adults | study links vitamin d deficient older adults with greater risk of developing depression |
changes in testing for human immunodeficiency virus sexually transmitted infections and hepatitis c virus in opioid treatment programs | proportion of opioid treatment programs offering on site testing for hiv stis declines |
hematopoietic stem cell transplantation in patients with gain of function stat mutation | world first stem cell treatment for lethal stat gene mutation shows disappointing but promising results |
feasibility of a critical care ultrasound curriculum delivered through a social media platform facebook | facebook viable method for implementing critical care ultrasound curriculum |
relaxation compensated amide proton transfer apt mri signal intensity is associated with survival and progression in high grade glioma patients | protein content as a marker for response to therapy in brain cancer |
effects of swim training on liver carcinogenesis in male wistar rats fed a low fat or high fat diet | swim training plus healthy diet factor in cancer fight |
il rap potentiates multiple oncogenic signaling pathways in aml | single surface protein boosts multiple oncogenic pathways in acute myeloid leukemia |
perinatal outcomes among women with bipolar disorder a population based cohort study | women with bipolar disorder at percent greater risk of delivering preterm babies |
quantitative tissue tracking cardiac magnetic resonance cmr of left atrial deformation and the risk of stroke in patients with atrial fibrillation | motion tracking mri tests reveal novel harbingers of stroke in people with common heart rhythm disorder |
targeting rna foci reduces pathology in ipsc derived motor neurons from c orf repeat patients. | lou gehrig s disease from patient stem cells to potential treatment strategy |
a genome editing strategy to treat hemoglobinopathies that recapitulates a mutation associated with a benign genetic condition | crispr gene editing reveals new therapeutic approach for blood disorders |
optimal targeting of seasonal influenza vaccination toward younger ages is robust to parameter uncertainty | flu vaccines aimed at younger populations could break annual transmission cycle |
universal or specific ? a modeling based comparison of broad spectrum influenza vaccines against conventional strain matched vaccines | key benefits of large scale use of universal over conventional flu vaccines |
cdk but not cdk is the sole cdk that is essential and sufficient to drive resumption of meiosis in mouse oocytes | discovery of a molecule that initiates maturation of mammalian eggs can lead to more ivf pregnancies |
m a rna modification controls cell fate transition in mammalian embryonic stem cells | loss of a chemical tag on rna keeps embryonic stem cells in suspended animation |
bedtime in preschool aged children and risk for adolescent obesity | early preschool bedtimes cut risk of obesity later on |
vitamin d deficiency its role in health and disease and current supplementation recommendations | widespread vitamin d deficiency likely due to sunscreen use increase of chronic diseases review finds |
chromatin signaling to kinetochores transregulation of dam methylation by histone h b ubiquitination | scientists discover secret life of chromatin dna histone combination a destination for cell signals also talks to other proteins |
kidney targeted inhibition of protein kinase c ameliorates nephrotoxic nephritis with restoration of mitochondrial dysfunction | inflammation inhibitor delivered directly to kidneys reverses course of destructive nephritis |
identification of four new susceptibility loci for testicular germ cell tumour | genetic testing could identify men at a fold increased risk of testicular cancer |
incident hiv during pregnancy and postpartum and risk of mother to child hiv transmission a systematic review and meta analysis | risk of hiv infection high during pregnancy the postpartum period |
very long chain tear film lipids produced by fatty acid elongase elovl prevent dry eye disease in mice | very long chain lipids could help prevent dry eye disease |
mechanisms of chronic muscle wasting and dysfunction after an intensive care unit stay a pilot study | many icu patients trade critical illness for new illness icu acquired weakness |
hemispheric sea ice distribution sets the glacial tempo | earth s orbital variations sea ice synch glacial periods |
apolipoprotein e apoe genotype is associated with elevated psychiatric distress in veterans with a history of mild to moderate traumatic brain injury | gene variant may increase psychiatric risk after traumatic brain injury |
thresholds in marsh resilience to the deepwater horizon oil spill | deepwater horizon oil spill caused widespread marsh erosion study shows |
histone deacetylase inhibition rescues structural and functional brain deficits in a mouse model of kabuki syndrome | drug treats inherited form of intellectual disability in mice |
impact of psychological factors on subjective disease activity assessments in patients with severe rheumatoid arthritis | depression higher than previously reported in people with severe rheumatoid arthritis |
metagenomic sequencing of hpv negative condylomas detects novel putative hpv types | hidden strains of hpv found in virus negative genital warts |
randomized intervention trial to decrease bisphenol a urine concentrations in women pilot study | reducing exposure to bisphenol a bpa lowers levels of this environmental estrogen in women |
improvement of insulin sensitivity after lean donor feces in metabolic syndrome is driven by baseline intestinal microbiota composition | fecal transplant success for diabetes might depend on the recipient s gut microbes |
does money make people right wing and inegalitarian a longitudinal study of lottery wins | money makes people right wing inegalitarian uk study finds |
hormonal contraceptives for contraception in overweight or obese women | hormonal contraceptives have mixed success among overweight women |
a live impaired fidelity coronavirus vaccine protects in an aged immunocompromised mouse model of lethal disease | new live vaccine approach for sars and novel coronaviruses discovered |
adaptation potential of european agriculture in response to climate change | european farmers importance of adapting to climate change |
rna cytosine methylation and methyltransferases mediate chromatin organization and azacytidine response and resistance in leukaemia | probing rna epigenetics and chromatin structures to predict drug resistance in leukemia |
risk factors for first venous thromboembolism around pregnancy a population based cohort study from the united kingdom | stillbirth or pre term birth outcomes linked to elevated risk of blood clots after pregnancy |
long term viability and function of transplanted islets macroencapsulated at high density are achieved by enhanced oxygen supply | implantable islet cells come with their own oxygen supply |
association between breakfast consumption and educational outcomes in year old children | study provides strongest evidence yet of a link between breakfast quality and educational outcomes |
outcomes among older patients receiving implantable cardioverter defibrillators for secondary prevention | study finds high survival rate for elderly patients with implantable defibrillator |
sox messenger cells orchestrate large scale skeletal regeneration in the mammalian rib | messenger cells bring good news for bone healing |
longitudinal effects of prenatal exposure to air pollutants on self regulatory capacities and social competence | prenatal exposure to air pollution linked to impulsivity emotional problems in children |
insect resistance to bt crops lessons from the first billion acres | biotech crops vs. pests successes and failures from the first billion acres |
arix a randomised trial of acupuncture v oral care sessions in patients with chronic xerostomia following treatment of head and neck cancer | acupuncture relieves symptoms of a dry mouth caused by radiotherapy for head and neck cancers study suggests |
dysfunctions of the basal ganglia cerebellar thalamo cortical system produce motor tics in tourette syndrome | brain s role in tourette tics simulated in new computational model |
obesity and overweight problems among individuals to years following acute rehabilitation for traumatic brain injury | obesity and overweight linked to long term health problems after traumatic brain injury |
earth s youngest banded iron formation implies ferruginous conditions in the early cambrian ocean | scientists discover earth s youngest banded iron formation in western china |