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BigScience Biomedical Datasets 114

[ { "id": "9678", "type": "title", "text": [ "Here, we present an overview of the current progress in miRNA research related to CNS disorders and also highlight the utility of LNA (locked nucleic acid)-modified oligonucleotides in the detection and modulation of miRNA activity. " ], "offsets": [ [ 0, 235 ] ] }, { "id": "9679", "type": "abstract", "text": [ "Recent studies have identified a molecular and ultimately pathogenic role for a subset of miRNAs in Alzheimer's disease and schizophrenia, including the characterization of their downstream CNS mRNA targets, such as beta-secretase (BACE1) and calmodulin-dependent protein kinase II (CaMKII). " ], "offsets": [ [ 236, 528 ] ] }, { "id": "9680", "type": "abstract", "text": [ "The intricate molecular networks mediated by an miRNA form a robust mechanism for rapid and potent responses to cellular events throughout the development of the human brain. " ], "offsets": [ [ 529, 704 ] ] }, { "id": "9681", "type": "abstract", "text": [ "Disruption of miRNA-based post-transcriptional regulation has been implicated in a range of CNS disorders as one miRNA is predicted to impact the expression of numerous downstream mRNA targets. " ], "offsets": [ [ 705, 899 ] ] }, { "id": "9682", "type": "abstract", "text": [ "Hundreds of non-coding regulatory RNA molecules called microRNAs (miRNAs) have been identified in the mammalian central nervous system (CNS) and are reported to mediate pivotal roles in many aspects of neuronal functions. " ], "offsets": [ [ 900, 1122 ] ] }, { "id": "9683", "type": "abstract", "text": [ "In recent years, there has been a shift in the conventional paradigms for transcriptional and translational regulation as extensive sequencing efforts have yielded new insights into the landscape of the human genome and transcriptome. " ], "offsets": [ [ 1123, 1358 ] ] }, { "id": "9684", "type": "abstract", "text": [ "microRNAs in CNS disorders. " ], "offsets": [ [ 1359, 1388 ] ] } ]

[ { "id": "9685", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 56, 61 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d200.s0.e0" } ] }, { "id": "9686", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 217, 222 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d200.s0.e1" } ] }, { "id": "9687", "type": "Relation_Trigger", "text": [ "modulation" ], "offsets": [ [ 203, 213 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d200.s0.e2" } ] }, { "id": "9688", "type": "Diseases", "text": [ "CNS disorders" ], "offsets": [ [ 82, 95 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d200.s0.e3" } ] }, { "id": "9689", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 326, 332 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d200.s1.e0" } ] }, { "id": "9690", "type": "Diseases", "text": [ "Alzheimer's disease" ], "offsets": [ [ 336, 355 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d200.s1.e1" } ] }, { "id": "9691", "type": "Diseases", "text": [ "schizophrenia" ], "offsets": [ [ 360, 373 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d200.s1.e2" } ] }, { "id": "9692", "type": "Genes/Proteins", "text": [ "BACE1" ], "offsets": [ [ 468, 473 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d200.s1.e3" } ] }, { "id": "9693", "type": "Relation_Trigger", "text": [ "targets" ], "offsets": [ [ 435, 442 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d200.s1.e4" } ] }, { "id": "9694", "type": "Genes/Proteins", "text": [ "beta-secretase" ], "offsets": [ [ 452, 466 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d200.s1.e5" } ] }, { "id": "9695", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 577, 582 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d200.s2.e0" } ] }, { "id": "9696", "type": "Species", "text": [ "human" ], "offsets": [ [ 691, 696 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d200.s2.e1" } ] }, { "id": "9697", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 818, 823 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d200.s3.e0" } ] }, { "id": "9698", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 719, 724 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d200.s3.e1" } ] }, { "id": "9699", "type": "Relation_Trigger", "text": [ "regulation" ], "offsets": [ [ 752, 762 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d200.s3.e2" } ] }, { "id": "9700", "type": "Diseases", "text": [ "CNS disorders" ], "offsets": [ [ 797, 810 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d200.s3.e3" } ] }, { "id": "9701", "type": "Relation_Trigger", "text": [ "targets" ], "offsets": [ [ 890, 897 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d200.s3.e4" } ] }, { "id": "9702", "type": "Non-Specific_miRNAs", "text": [ "microRNAs" ], "offsets": [ [ 955, 964 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d200.s4.e0" } ] }, { "id": "9703", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 966, 972 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d200.s4.e1" } ] }, { "id": "9704", "type": "Relation_Trigger", "text": [ "regulatory" ], "offsets": [ [ 923, 933 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d200.s4.e2" } ] }, { "id": "9705", "type": "Relation_Trigger", "text": [ "translational regulation" ], "offsets": [ [ 1217, 1241 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d200.s5.e0" } ] }, { "id": "9706", "type": "Species", "text": [ "human" ], "offsets": [ [ 1326, 1331 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d200.s5.e1" } ] }, { "id": "9707", "type": "Non-Specific_miRNAs", "text": [ "microRNAs" ], "offsets": [ [ 1359, 1368 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d200.s6.e0" } ] }, { "id": "9708", "type": "Diseases", "text": [ "CNS disorders" ], "offsets": [ [ 1372, 1385 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d200.s6.e1" } ] } ]

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[ { "id": "9709", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d200.s0.e0", "arg2_id": "miRNA-corp.d200.s0.e3", "normalized": [] }, { "id": "9710", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d200.s0.e1", "arg2_id": "miRNA-corp.d200.s0.e3", "normalized": [] }, { "id": "9711", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d200.s1.e0", "arg2_id": "miRNA-corp.d200.s1.e3", "normalized": [] }, { "id": "9712", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d200.s1.e0", "arg2_id": "miRNA-corp.d200.s1.e5", "normalized": [] }, { "id": "9713", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d200.s1.e0", "arg2_id": "miRNA-corp.d200.s1.e1", "normalized": [] }, { "id": "9714", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d200.s1.e0", "arg2_id": "miRNA-corp.d200.s1.e2", "normalized": [] }, { "id": "9715", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d200.s3.e1", "arg2_id": "miRNA-corp.d200.s3.e3", "normalized": [] }, { "id": "9716", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d200.s3.e0", "arg2_id": "miRNA-corp.d200.s3.e3", "normalized": [] }, { "id": "9717", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d200.s6.e0", "arg2_id": "miRNA-corp.d200.s6.e1", "normalized": [] } ]