Datasets:

bigbio

/

mirna

like 1

Follow

BigScience Biomedical Datasets 110

[ { "id": "4644", "type": "title", "text": [ "Specifically, we highlight the importance of unbiased association studies and follow-up functional experiments for providing a clearer picture of the extent to which microRNA target site variations are relevant in various human diseases. " ], "offsets": [ [ 0, 240 ] ] }, { "id": "4645", "type": "abstract", "text": [ "Several studies have identified genetic variants in miRNA target sites that are claimed to be associated with disorders ranging from Parkinson's disease to cancer. " ], "offsets": [ [ 241, 405 ] ] }, { "id": "4646", "type": "abstract", "text": [ "They have been implicated in a broad range of biological processes, and miRNA-related genetic alterations probably underlie more human diseases than currently appreciated. " ], "offsets": [ [ 406, 578 ] ] }, { "id": "4647", "type": "abstract", "text": [ "MicroRNAs (miRNAs) are important regulators of eukaryotic gene expression. " ], "offsets": [ [ 579, 654 ] ] }, { "id": "4648", "type": "abstract", "text": [ "MicroRNA target site polymorphisms and human disease. " ], "offsets": [ [ 655, 710 ] ] } ]

[ { "id": "4649", "type": "Non-Specific_miRNAs", "text": [ "microRNA" ], "offsets": [ [ 166, 174 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d100.s0.e0" } ] }, { "id": "4650", "type": "Relation_Trigger", "text": [ "target" ], "offsets": [ [ 175, 181 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d100.s0.e1" } ] }, { "id": "4651", "type": "Relation_Trigger", "text": [ "association" ], "offsets": [ [ 54, 65 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d100.s0.e2" } ] }, { "id": "4652", "type": "Species", "text": [ "human" ], "offsets": [ [ 222, 227 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d100.s0.e3" } ] }, { "id": "4653", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 293, 298 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d100.s3.e0" } ] }, { "id": "4654", "type": "Diseases", "text": [ "Parkinson's disease" ], "offsets": [ [ 374, 393 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d100.s3.e1" } ] }, { "id": "4655", "type": "Relation_Trigger", "text": [ "associated" ], "offsets": [ [ 335, 345 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d100.s3.e2" } ] }, { "id": "4656", "type": "Relation_Trigger", "text": [ "target" ], "offsets": [ [ 299, 305 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d100.s3.e3" } ] }, { "id": "4657", "type": "Diseases", "text": [ "cancer" ], "offsets": [ [ 397, 403 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d100.s3.e4" } ] }, { "id": "4658", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 478, 483 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d100.s4.e0" } ] }, { "id": "4659", "type": "Species", "text": [ "human" ], "offsets": [ [ 535, 540 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d100.s4.e1" } ] }, { "id": "4660", "type": "Non-Specific_miRNAs", "text": [ "MicroRNAs" ], "offsets": [ [ 579, 588 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d100.s5.e0" } ] }, { "id": "4661", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 590, 596 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d100.s5.e1" } ] }, { "id": "4662", "type": "Relation_Trigger", "text": [ "regulators of eukaryotic gene expression" ], "offsets": [ [ 612, 652 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d100.s5.e2" } ] }, { "id": "4663", "type": "Non-Specific_miRNAs", "text": [ "MicroRNA" ], "offsets": [ [ 655, 663 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d100.s6.e0" } ] }, { "id": "4664", "type": "Relation_Trigger", "text": [ "target" ], "offsets": [ [ 664, 670 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d100.s6.e1" } ] }, { "id": "4665", "type": "Species", "text": [ "human" ], "offsets": [ [ 694, 699 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d100.s6.e2" } ] } ]

[]

[]

[ { "id": "4666", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d100.s3.e0", "arg2_id": "miRNA-corp.d100.s3.e4", "normalized": [] }, { "id": "4667", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d100.s3.e0", "arg2_id": "miRNA-corp.d100.s3.e1", "normalized": [] } ]

[ { "id": "4669", "type": "title", "text": [ "Human traumatic brain injury alters plasma microRNA levels. " ], "offsets": [ [ 0, 61 ] ] }, { "id": "4670", "type": "abstract", "text": [ "Circulating microRNAs (miRNAs) present in the serum/plasma are characteristically altered in many pathological conditions, and have been employed as diagnostic markers for specific diseases. " ], "offsets": [ [ 62, 253 ] ] }, { "id": "4671", "type": "abstract", "text": [ "We examined if plasma miRNA levels are altered in patients with traumatic brain injury (TBI) relative to matched healthy volunteers, and explored their potential for use as diagnostic TBI biomarkers. " ], "offsets": [ [ 254, 454 ] ] }, { "id": "4672", "type": "abstract", "text": [ "The plasma miRNA profiles from severe TBI patients (Glasgow Coma Scale [GCS] score ≤8) and age-, gender-, and race-matched healthy volunteers were compared by microarray analysis. " ], "offsets": [ [ 455, 635 ] ] }, { "id": "4673", "type": "abstract", "text": [ "Of the 108 miRNAs identified in healthy volunteer plasma, 52 were altered after severe TBI, including 33 with decreased and 19 with increased relative abundance. " ], "offsets": [ [ 636, 798 ] ] }, { "id": "4674", "type": "abstract", "text": [ "An additional 8 miRNAs were detected only in the TBI plasma. " ], "offsets": [ [ 799, 860 ] ] }, { "id": "4675", "type": "abstract", "text": [ "We used quantitative RT-PCR to determine if plasma miRNAs could identify TBI patients within the first 24 h post-injury. " ], "offsets": [ [ 861, 982 ] ] }, { "id": "4676", "type": "abstract", "text": [ "Receiver operating characteristic curve analysis indicated that miR-16, miR-92a, and miR-765 were good markers of severe TBI (0.89, 0.82, and 0.86 AUC values, respectively). " ], "offsets": [ [ 983, 1157 ] ] }, { "id": "4677", "type": "abstract", "text": [ "Multiple logistic regression analysis revealed that combining these miRNAs markedly increased diagnostic accuracy (100% specificity and 100% sensitivity), compared to either healthy volunteers or orthopedic injury patients. " ], "offsets": [ [ 1158, 1382 ] ] }, { "id": "4678", "type": "abstract", "text": [ "In mild TBI patients (GCS score > 12), miR-765 levels were unchanged, while the plasma levels of miR-92a and miR-16 were significantly increased within the first 24 h of injury compared to healthy volunteers, and had AUC values of 0.78 and 0.82, respectively. " ], "offsets": [ [ 1383, 1643 ] ] }, { "id": "4679", "type": "abstract", "text": [ "Plasma-derived miRNA biomarkers, used in combination with established clinical practices such as imaging, neurocognitive, and motor examinations, have the potential to improve TBI patient classification and possibly management. " ], "offsets": [ [ 1644, 1874 ] ] }, { "id": "4680", "type": "abstract", "text": [ "Our results demonstrate that circulating miRNA levels are altered after TBI, providing a rich new source of potential molecular biomarkers. " ], "offsets": [ [ 1875, 2015 ] ] } ]

[ { "id": "4681", "type": "Non-Specific_miRNAs", "text": [ "microRNA" ], "offsets": [ [ 43, 51 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d101.s0.e0" } ] }, { "id": "4682", "type": "Diseases", "text": [ "brain injury" ], "offsets": [ [ 16, 28 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d101.s0.e1" } ] }, { "id": "4683", "type": "Relation_Trigger", "text": [ "alters plasma microRNA levels" ], "offsets": [ [ 29, 58 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d101.s0.e2" } ] }, { "id": "4684", "type": "Species", "text": [ "Human" ], "offsets": [ [ 0, 5 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d101.s0.e3" } ] }, { "id": "4685", "type": "Non-Specific_miRNAs", "text": [ "microRNAs" ], "offsets": [ [ 74, 83 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d101.s1.e0" } ] }, { "id": "4686", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 85, 91 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d101.s1.e1" } ] }, { "id": "4687", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 276, 281 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d101.s2.e0" } ] }, { "id": "4688", "type": "Relation_Trigger", "text": [ "levels are altered" ], "offsets": [ [ 282, 300 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d101.s2.e1" } ] }, { "id": "4689", "type": "Diseases", "text": [ "TBI" ], "offsets": [ [ 342, 345 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d101.s2.e2" } ] }, { "id": "4690", "type": "Diseases", "text": [ "traumatic brain injury" ], "offsets": [ [ 318, 340 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d101.s2.e3" } ] }, { "id": "4691", "type": "Diseases", "text": [ "TBI" ], "offsets": [ [ 438, 441 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d101.s2.e4" } ] }, { "id": "4692", "type": "Species", "text": [ "patients" ], "offsets": [ [ 304, 312 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d101.s2.e5" } ] }, { "id": "4693", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 466, 471 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d101.s3.e0" } ] }, { "id": "4694", "type": "Diseases", "text": [ "TBI" ], "offsets": [ [ 493, 496 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d101.s3.e1" } ] }, { "id": "4695", "type": "Species", "text": [ "patients" ], "offsets": [ [ 497, 505 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d101.s3.e2" } ] }, { "id": "4696", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 647, 653 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d101.s4.e0" } ] }, { "id": "4697", "type": "Diseases", "text": [ "TBI" ], "offsets": [ [ 723, 726 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d101.s4.e1" } ] }, { "id": "4698", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 815, 821 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d101.s5.e0" } ] }, { "id": "4699", "type": "Diseases", "text": [ "TBI" ], "offsets": [ [ 848, 851 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d101.s5.e1" } ] }, { "id": "4700", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 912, 918 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d101.s6.e0" } ] }, { "id": "4701", "type": "Diseases", "text": [ "TBI" ], "offsets": [ [ 934, 937 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d101.s6.e1" } ] }, { "id": "4702", "type": "Diseases", "text": [ "injury" ], "offsets": [ [ 974, 980 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d101.s6.e2" } ] }, { "id": "4703", "type": "Species", "text": [ "patients" ], "offsets": [ [ 938, 946 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d101.s6.e3" } ] }, { "id": "4704", "type": "Diseases", "text": [ "TBI" ], "offsets": [ [ 1104, 1107 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d101.s7.e0" } ] }, { "id": "4705", "type": "Specific_miRNAs", "text": [ "miR-765" ], "offsets": [ [ 1068, 1075 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d101.s7.e1" } ] }, { "id": "4706", "type": "Specific_miRNAs", "text": [ "miR-92a" ], "offsets": [ [ 1055, 1062 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d101.s7.e2" } ] }, { "id": "4707", "type": "Specific_miRNAs", "text": [ "miR-16" ], "offsets": [ [ 1047, 1053 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d101.s7.e3" } ] }, { "id": "4708", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1226, 1232 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d101.s8.e0" } ] }, { "id": "4709", "type": "Diseases", "text": [ "orthopedic injury" ], "offsets": [ [ 1354, 1371 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d101.s8.e1" } ] }, { "id": "4710", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1372, 1380 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d101.s8.e2" } ] }, { "id": "4711", "type": "Relation_Trigger", "text": [ "sma levels of miR-92a and miR-16 were significantly incre" ], "offsets": [ [ 1466, 1523 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d101.s9.e0" } ] }, { "id": "4712", "type": "Diseases", "text": [ "TBI" ], "offsets": [ [ 1391, 1394 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d101.s9.e1" } ] }, { "id": "4713", "type": "Specific_miRNAs", "text": [ "miR-16" ], "offsets": [ [ 1492, 1498 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d101.s9.e2" } ] }, { "id": "4714", "type": "Specific_miRNAs", "text": [ "miR-92a" ], "offsets": [ [ 1480, 1487 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d101.s9.e3" } ] }, { "id": "4715", "type": "Specific_miRNAs", "text": [ "miR-765" ], "offsets": [ [ 1422, 1429 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d101.s9.e4" } ] }, { "id": "4716", "type": "Diseases", "text": [ "injury" ], "offsets": [ [ 1553, 1559 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d101.s9.e5" } ] }, { "id": "4717", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1395, 1403 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d101.s9.e6" } ] }, { "id": "4718", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1659, 1664 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d101.s10.e0" } ] }, { "id": "4719", "type": "Diseases", "text": [ "TBI" ], "offsets": [ [ 1820, 1823 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d101.s10.e1" } ] }, { "id": "4720", "type": "Species", "text": [ "patient" ], "offsets": [ [ 1824, 1831 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d101.s10.e2" } ] }, { "id": "4721", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1916, 1921 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d101.s11.e0" } ] }, { "id": "4722", "type": "Relation_Trigger", "text": [ "levels are altered" ], "offsets": [ [ 1922, 1940 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d101.s11.e1" } ] }, { "id": "4723", "type": "Diseases", "text": [ "TBI" ], "offsets": [ [ 1947, 1950 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d101.s11.e2" } ] } ]

[]

[]

[ { "id": "4724", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d101.s0.e0", "arg2_id": "miRNA-corp.d101.s0.e1", "normalized": [] }, { "id": "4725", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d101.s2.e0", "arg2_id": "miRNA-corp.d101.s2.e2", "normalized": [] }, { "id": "4726", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d101.s2.e0", "arg2_id": "miRNA-corp.d101.s2.e3", "normalized": [] }, { "id": "4727", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d101.s2.e0", "arg2_id": "miRNA-corp.d101.s2.e4", "normalized": [] }, { "id": "4728", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d101.s3.e0", "arg2_id": "miRNA-corp.d101.s3.e1", "normalized": [] }, { "id": "4729", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d101.s4.e0", "arg2_id": "miRNA-corp.d101.s4.e1", "normalized": [] }, { "id": "4730", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d101.s5.e0", "arg2_id": "miRNA-corp.d101.s5.e1", "normalized": [] }, { "id": "4731", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d101.s6.e0", "arg2_id": "miRNA-corp.d101.s6.e1", "normalized": [] }, { "id": "4732", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d101.s6.e0", "arg2_id": "miRNA-corp.d101.s6.e2", "normalized": [] }, { "id": "4733", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d101.s7.e1", "arg2_id": "miRNA-corp.d101.s7.e0", "normalized": [] }, { "id": "4734", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d101.s7.e2", "arg2_id": "miRNA-corp.d101.s7.e0", "normalized": [] }, { "id": "4735", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d101.s7.e3", "arg2_id": "miRNA-corp.d101.s7.e0", "normalized": [] }, { "id": "4736", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d101.s8.e0", "arg2_id": "miRNA-corp.d101.s8.e1", "normalized": [] }, { "id": "4737", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d101.s9.e2", "arg2_id": "miRNA-corp.d101.s9.e1", "normalized": [] }, { "id": "4738", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d101.s9.e2", "arg2_id": "miRNA-corp.d101.s9.e5", "normalized": [] }, { "id": "4739", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d101.s9.e3", "arg2_id": "miRNA-corp.d101.s9.e1", "normalized": [] }, { "id": "4740", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d101.s9.e3", "arg2_id": "miRNA-corp.d101.s9.e5", "normalized": [] }, { "id": "4741", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d101.s9.e4", "arg2_id": "miRNA-corp.d101.s9.e1", "normalized": [] }, { "id": "4742", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d101.s9.e4", "arg2_id": "miRNA-corp.d101.s9.e5", "normalized": [] }, { "id": "4743", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d101.s10.e0", "arg2_id": "miRNA-corp.d101.s10.e1", "normalized": [] }, { "id": "4744", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d101.s11.e0", "arg2_id": "miRNA-corp.d101.s11.e2", "normalized": [] } ]

[ { "id": "4746", "type": "title", "text": [ "MicroRNA-205 inhibits tumor cell migration through down-regulating the expression of the LDL receptor-related protein 1. Low-density lipoprotein receptor-related protein 1 (LRP1) is a multifunctional endocytic receptor that plays critical roles in the pathogenesis of several human diseases including tumor metastasis and Alzheimer's disease. " ], "offsets": [ [ 0, 344 ] ] }, { "id": "4747", "type": "abstract", "text": [ "In human cell lines, we found that miR-205 down-regulates the expression of LRP1 by targeting sequences in the 3'UTR of LRP1 mRNA. " ], "offsets": [ [ 345, 476 ] ] }, { "id": "4748", "type": "abstract", "text": [ "However, mechanisms that regulate LRP1 expression under physiological and pathophysiological conditions are not unclear. " ], "offsets": [ [ 477, 598 ] ] }, { "id": "4749", "type": "abstract", "text": [ "The ectopic expression of miR-205 also significantly mitigated migration of both U87 and SK-LU-1 cells. " ], "offsets": [ [ 599, 703 ] ] }, { "id": "4750", "type": "abstract", "text": [ "This effect was abolished by deleting the miR-205 seed site in the 3'UTR of LRP1. " ], "offsets": [ [ 704, 786 ] ] }, { "id": "4751", "type": "abstract", "text": [ "These results, for the first time, demonstrate that expression of human LRP1 is regulated in part by a specific miRNA, leading to decreased tumor cell migration. " ], "offsets": [ [ 787, 951 ] ] } ]

[ { "id": "4752", "type": "Specific_miRNAs", "text": [ "MicroRNA-205" ], "offsets": [ [ 0, 12 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d102.s0.e0" } ] }, { "id": "4753", "type": "Genes/Proteins", "text": [ "Low-density lipoprotein receptor-related protein 1" ], "offsets": [ [ 122, 172 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d102.s0.e1" } ] }, { "id": "4754", "type": "Genes/Proteins", "text": [ "LRP1" ], "offsets": [ [ 174, 178 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d102.s0.e2" } ] }, { "id": "4755", "type": "Diseases", "text": [ "Alzheimer's disease" ], "offsets": [ [ 323, 342 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d102.s0.e3" } ] }, { "id": "4756", "type": "Genes/Proteins", "text": [ "LDL receptor-related protein 1" ], "offsets": [ [ 89, 119 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d102.s0.e4" } ] }, { "id": "4757", "type": "Relation_Trigger", "text": [ "down-regulating the expression" ], "offsets": [ [ 51, 81 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d102.s0.e5" } ] }, { "id": "4758", "type": "Relation_Trigger", "text": [ "inhibits" ], "offsets": [ [ 13, 21 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d102.s0.e6" } ] }, { "id": "4759", "type": "Diseases", "text": [ "tumor" ], "offsets": [ [ 22, 27 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d102.s0.e7" } ] }, { "id": "4760", "type": "Diseases", "text": [ "tumor" ], "offsets": [ [ 302, 307 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d102.s0.e8" } ] }, { "id": "4761", "type": "Species", "text": [ "human" ], "offsets": [ [ 277, 282 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d102.s0.e9" } ] }, { "id": "4762", "type": "Specific_miRNAs", "text": [ "miR-205" ], "offsets": [ [ 380, 387 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d102.s1.e0" } ] }, { "id": "4763", "type": "Genes/Proteins", "text": [ "LRP1" ], "offsets": [ [ 421, 425 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d102.s1.e1" } ] }, { "id": "4764", "type": "Genes/Proteins", "text": [ "LRP1" ], "offsets": [ [ 465, 469 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d102.s1.e2" } ] }, { "id": "4765", "type": "Relation_Trigger", "text": [ "down-regulates the expression" ], "offsets": [ [ 388, 417 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d102.s1.e3" } ] }, { "id": "4766", "type": "Relation_Trigger", "text": [ "targeting sequences in the 3'UTR" ], "offsets": [ [ 429, 461 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d102.s1.e4" } ] }, { "id": "4767", "type": "Species", "text": [ "human" ], "offsets": [ [ 348, 353 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d102.s1.e5" } ] }, { "id": "4768", "type": "Genes/Proteins", "text": [ "LRP1" ], "offsets": [ [ 511, 515 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d102.s2.e0" } ] }, { "id": "4769", "type": "Relation_Trigger", "text": [ "regulate LRP1 expression" ], "offsets": [ [ 502, 526 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d102.s2.e1" } ] }, { "id": "4770", "type": "Specific_miRNAs", "text": [ "miR-205" ], "offsets": [ [ 625, 632 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d102.s3.e0" } ] }, { "id": "4771", "type": "Relation_Trigger", "text": [ "ectopic expression" ], "offsets": [ [ 603, 621 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d102.s3.e1" } ] }, { "id": "4772", "type": "Specific_miRNAs", "text": [ "miR-205" ], "offsets": [ [ 746, 753 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d102.s4.e0" } ] }, { "id": "4773", "type": "Genes/Proteins", "text": [ "LRP1" ], "offsets": [ [ 780, 784 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d102.s4.e1" } ] }, { "id": "4774", "type": "Genes/Proteins", "text": [ "LRP1" ], "offsets": [ [ 859, 863 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d102.s5.e0" } ] }, { "id": "4775", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 899, 904 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d102.s5.e1" } ] }, { "id": "4776", "type": "Relation_Trigger", "text": [ "expression of human LRP1 is regulated" ], "offsets": [ [ 839, 876 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d102.s5.e2" } ] }, { "id": "4777", "type": "Diseases", "text": [ "tumor" ], "offsets": [ [ 927, 932 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d102.s5.e3" } ] }, { "id": "4778", "type": "Species", "text": [ "human" ], "offsets": [ [ 853, 858 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d102.s5.e4" } ] } ]

[]

[]

[ { "id": "4779", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d102.s0.e0", "arg2_id": "miRNA-corp.d102.s0.e1", "normalized": [] }, { "id": "4780", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d102.s0.e0", "arg2_id": "miRNA-corp.d102.s0.e4", "normalized": [] }, { "id": "4781", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d102.s0.e0", "arg2_id": "miRNA-corp.d102.s0.e2", "normalized": [] }, { "id": "4782", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d102.s0.e0", "arg2_id": "miRNA-corp.d102.s0.e7", "normalized": [] }, { "id": "4783", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d102.s0.e0", "arg2_id": "miRNA-corp.d102.s0.e8", "normalized": [] }, { "id": "4784", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d102.s0.e0", "arg2_id": "miRNA-corp.d102.s0.e3", "normalized": [] }, { "id": "4785", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d102.s1.e0", "arg2_id": "miRNA-corp.d102.s1.e1", "normalized": [] }, { "id": "4786", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d102.s1.e0", "arg2_id": "miRNA-corp.d102.s1.e2", "normalized": [] }, { "id": "4787", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d102.s4.e0", "arg2_id": "miRNA-corp.d102.s4.e1", "normalized": [] }, { "id": "4788", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d102.s5.e1", "arg2_id": "miRNA-corp.d102.s5.e0", "normalized": [] }, { "id": "4789", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d102.s5.e1", "arg2_id": "miRNA-corp.d102.s5.e3", "normalized": [] } ]

[ { "id": "4791", "type": "title", "text": [ "In neurodegenerative disorders such as Alzheimer's disease (AD), brain miRNA profiles are altered; thus miRNA dysfunction could be both a cause and a consequence of disease. " ], "offsets": [ [ 0, 174 ] ] }, { "id": "4792", "type": "abstract", "text": [ "These small non-coding RNA regulators are highly enriched in brain where they play key roles in neuronal development, plasticity and disease. " ], "offsets": [ [ 175, 317 ] ] }, { "id": "4793", "type": "abstract", "text": [ "Normal brain development and function depends on microRNA (miRNA) networks to fine tune the balance between the transcriptome and proteome of the cell. " ], "offsets": [ [ 318, 470 ] ] }, { "id": "4794", "type": "abstract", "text": [ "Neuronal microRNA deregulation in response to Alzheimer's disease amyloid-beta. " ], "offsets": [ [ 471, 552 ] ] }, { "id": "4795", "type": "abstract", "text": [ "Bioinformatic analysis predicts that the deregulated miRNAs are likely to affect target genes present in prominent neuronal pathways known to be disrupted in AD. Remarkably, we also found that the miRNA deregulation in hippocampal cultures was paralleled in vivo by a deregulation in the hippocampus of Abeta42-depositing APP23 mice, at the onset of Abeta plaque formation. " ], "offsets": [ [ 553, 927 ] ] }, { "id": "4796", "type": "abstract", "text": [ "Time-course assays of neuronal Abeta treatments show that Abeta is in fact a powerful regulator of miRNA levels as the response of certain mature miRNAs is extremely rapid. " ], "offsets": [ [ 928, 1101 ] ] }, { "id": "4797", "type": "abstract", "text": [ "We used sensitive TaqMan low density miRNA arrays (TLDA) on murine primary hippocampal cultures to show that about half of all miRNAs tested were down-regulated in response to Abeta peptides. " ], "offsets": [ [ 1102, 1294 ] ] }, { "id": "4798", "type": "abstract", "text": [ "Our study dissects the complexity of human AD pathology, and addresses the hypothesis that amyloid-beta (Abeta) itself, a known causative factor of AD, causes neuronal miRNA deregulation, which could contribute to the pathomechanisms of AD. " ], "offsets": [ [ 1295, 1536 ] ] }, { "id": "4799", "type": "abstract", "text": [ "In addition, the miRNA deregulation in hippocampal cultures and APP23 hippocampus overlaps with those obtained in human AD studies. " ], "offsets": [ [ 1537, 1669 ] ] }, { "id": "4800", "type": "abstract", "text": [ "Taken together, our findings suggest that neuronal miRNA deregulation in response to an insult by Abeta may be an important factor contributing to the cascade of events leading to AD. " ], "offsets": [ [ 1670, 1856 ] ] } ]

[ { "id": "4801", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 71, 76 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d103.s0.e0" } ] }, { "id": "4802", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 104, 109 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d103.s0.e1" } ] }, { "id": "4803", "type": "Diseases", "text": [ "Alzheimer's disease" ], "offsets": [ [ 39, 58 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d103.s0.e2" } ] }, { "id": "4804", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 60, 62 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d103.s0.e3" } ] }, { "id": "4805", "type": "Relation_Trigger", "text": [ "miRNA profiles are altered" ], "offsets": [ [ 71, 97 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d103.s0.e4" } ] }, { "id": "4806", "type": "Relation_Trigger", "text": [ "dysfunction" ], "offsets": [ [ 110, 121 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d103.s0.e5" } ] }, { "id": "4807", "type": "Diseases", "text": [ "neurodegenerative disorders" ], "offsets": [ [ 3, 30 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d103.s0.e6" } ] }, { "id": "4808", "type": "Relation_Trigger", "text": [ "regulators" ], "offsets": [ [ 202, 212 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d103.s1.e0" } ] }, { "id": "4809", "type": "Non-Specific_miRNAs", "text": [ "microRNA" ], "offsets": [ [ 367, 375 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d103.s2.e0" } ] }, { "id": "4810", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 377, 382 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d103.s2.e1" } ] }, { "id": "4811", "type": "Non-Specific_miRNAs", "text": [ "microRNA" ], "offsets": [ [ 480, 488 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d103.s3.e0" } ] }, { "id": "4812", "type": "Diseases", "text": [ "Alzheimer's disease" ], "offsets": [ [ 517, 536 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d103.s3.e1" } ] }, { "id": "4813", "type": "Genes/Proteins", "text": [ "amyloid-beta" ], "offsets": [ [ 537, 549 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d103.s3.e2" } ] }, { "id": "4814", "type": "Relation_Trigger", "text": [ "deregulation" ], "offsets": [ [ 489, 501 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d103.s3.e3" } ] }, { "id": "4815", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 606, 612 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d103.s4.e0" } ] }, { "id": "4816", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 750, 755 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d103.s4.e1" } ] }, { "id": "4817", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 711, 713 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d103.s4.e2" } ] }, { "id": "4818", "type": "Genes/Proteins", "text": [ "Abeta" ], "offsets": [ [ 903, 908 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d103.s4.e3" } ] }, { "id": "4819", "type": "Relation_Trigger", "text": [ "deregulated" ], "offsets": [ [ 594, 605 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d103.s4.e4" } ] }, { "id": "4820", "type": "Relation_Trigger", "text": [ "deregulation" ], "offsets": [ [ 756, 768 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d103.s4.e5" } ] }, { "id": "4821", "type": "Relation_Trigger", "text": [ "deregulation" ], "offsets": [ [ 821, 833 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d103.s4.e6" } ] }, { "id": "4822", "type": "Relation_Trigger", "text": [ "target" ], "offsets": [ [ 634, 640 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d103.s4.e7" } ] }, { "id": "4823", "type": "Genes/Proteins", "text": [ "Abeta42" ], "offsets": [ [ 856, 863 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d103.s4.e8" } ] }, { "id": "4824", "type": "Species", "text": [ "mice" ], "offsets": [ [ 881, 885 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d103.s4.e9" } ] }, { "id": "4825", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1027, 1032 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d103.s5.e0" } ] }, { "id": "4826", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1074, 1080 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d103.s5.e1" } ] }, { "id": "4827", "type": "Genes/Proteins", "text": [ "Abeta" ], "offsets": [ [ 959, 964 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d103.s5.e2" } ] }, { "id": "4828", "type": "Genes/Proteins", "text": [ "Abeta" ], "offsets": [ [ 986, 991 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d103.s5.e3" } ] }, { "id": "4829", "type": "Relation_Trigger", "text": [ "regulator of miRNA levels" ], "offsets": [ [ 1014, 1039 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d103.s5.e4" } ] }, { "id": "4830", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1229, 1235 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d103.s6.e0" } ] }, { "id": "4831", "type": "Genes/Proteins", "text": [ "Abeta" ], "offsets": [ [ 1278, 1283 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d103.s6.e1" } ] }, { "id": "4832", "type": "Relation_Trigger", "text": [ "down-regulated" ], "offsets": [ [ 1248, 1262 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d103.s6.e2" } ] }, { "id": "4833", "type": "Species", "text": [ "murine" ], "offsets": [ [ 1162, 1168 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d103.s6.e3" } ] }, { "id": "4834", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1463, 1468 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d103.s7.e0" } ] }, { "id": "4835", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 1338, 1340 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d103.s7.e1" } ] }, { "id": "4836", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 1443, 1445 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d103.s7.e2" } ] }, { "id": "4837", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 1532, 1534 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d103.s7.e3" } ] }, { "id": "4838", "type": "Genes/Proteins", "text": [ "amyloid-beta" ], "offsets": [ [ 1386, 1398 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d103.s7.e4" } ] }, { "id": "4839", "type": "Genes/Proteins", "text": [ "Abeta" ], "offsets": [ [ 1400, 1405 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d103.s7.e5" } ] }, { "id": "4840", "type": "Relation_Trigger", "text": [ "deregulation" ], "offsets": [ [ 1469, 1481 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d103.s7.e6" } ] }, { "id": "4841", "type": "Species", "text": [ "human" ], "offsets": [ [ 1332, 1337 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d103.s7.e7" } ] }, { "id": "4842", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1554, 1559 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d103.s8.e0" } ] }, { "id": "4843", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 1657, 1659 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d103.s8.e1" } ] }, { "id": "4844", "type": "Relation_Trigger", "text": [ "deregulation" ], "offsets": [ [ 1560, 1572 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d103.s8.e2" } ] }, { "id": "4845", "type": "Species", "text": [ "human" ], "offsets": [ [ 1651, 1656 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d103.s8.e3" } ] }, { "id": "4846", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1721, 1726 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d103.s9.e0" } ] }, { "id": "4847", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 1850, 1852 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d103.s9.e1" } ] }, { "id": "4848", "type": "Genes/Proteins", "text": [ "Abeta" ], "offsets": [ [ 1768, 1773 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d103.s9.e2" } ] }, { "id": "4849", "type": "Relation_Trigger", "text": [ "deregulation" ], "offsets": [ [ 1727, 1739 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d103.s9.e3" } ] } ]

[]

[]

[ { "id": "4850", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d103.s0.e0", "arg2_id": "miRNA-corp.d103.s0.e2", "normalized": [] }, { "id": "4851", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d103.s0.e0", "arg2_id": "miRNA-corp.d103.s0.e3", "normalized": [] }, { "id": "4852", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d103.s0.e0", "arg2_id": "miRNA-corp.d103.s0.e6", "normalized": [] }, { "id": "4853", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d103.s0.e1", "arg2_id": "miRNA-corp.d103.s0.e2", "normalized": [] }, { "id": "4854", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d103.s0.e1", "arg2_id": "miRNA-corp.d103.s0.e3", "normalized": [] }, { "id": "4855", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d103.s0.e1", "arg2_id": "miRNA-corp.d103.s0.e6", "normalized": [] }, { "id": "4856", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d103.s3.e0", "arg2_id": "miRNA-corp.d103.s3.e1", "normalized": [] }, { "id": "4857", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d103.s3.e0", "arg2_id": "miRNA-corp.d103.s3.e2", "normalized": [] }, { "id": "4858", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d103.s4.e1", "arg2_id": "miRNA-corp.d103.s4.e2", "normalized": [] }, { "id": "4859", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d103.s4.e1", "arg2_id": "miRNA-corp.d103.s4.e3", "normalized": [] }, { "id": "4860", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d103.s4.e1", "arg2_id": "miRNA-corp.d103.s4.e8", "normalized": [] }, { "id": "4861", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d103.s4.e0", "arg2_id": "miRNA-corp.d103.s4.e2", "normalized": [] }, { "id": "4862", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d103.s4.e0", "arg2_id": "miRNA-corp.d103.s4.e3", "normalized": [] }, { "id": "4863", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d103.s4.e0", "arg2_id": "miRNA-corp.d103.s4.e8", "normalized": [] }, { "id": "4864", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d103.s5.e0", "arg2_id": "miRNA-corp.d103.s5.e2", "normalized": [] }, { "id": "4865", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d103.s5.e0", "arg2_id": "miRNA-corp.d103.s5.e3", "normalized": [] }, { "id": "4866", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d103.s5.e1", "arg2_id": "miRNA-corp.d103.s5.e2", "normalized": [] }, { "id": "4867", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d103.s5.e1", "arg2_id": "miRNA-corp.d103.s5.e3", "normalized": [] }, { "id": "4868", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d103.s6.e0", "arg2_id": "miRNA-corp.d103.s6.e1", "normalized": [] }, { "id": "4869", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d103.s7.e0", "arg2_id": "miRNA-corp.d103.s7.e1", "normalized": [] }, { "id": "4870", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d103.s7.e0", "arg2_id": "miRNA-corp.d103.s7.e2", "normalized": [] }, { "id": "4871", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d103.s7.e0", "arg2_id": "miRNA-corp.d103.s7.e3", "normalized": [] }, { "id": "4872", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d103.s7.e0", "arg2_id": "miRNA-corp.d103.s7.e4", "normalized": [] }, { "id": "4873", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d103.s7.e0", "arg2_id": "miRNA-corp.d103.s7.e5", "normalized": [] }, { "id": "4874", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d103.s8.e0", "arg2_id": "miRNA-corp.d103.s8.e1", "normalized": [] }, { "id": "4875", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d103.s9.e0", "arg2_id": "miRNA-corp.d103.s9.e1", "normalized": [] }, { "id": "4876", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d103.s9.e0", "arg2_id": "miRNA-corp.d103.s9.e2", "normalized": [] } ]

[ { "id": "4878", "type": "title", "text": [ "We report here on a patient who was treated for an atypical brain meningioma with multiple surgeries and multiple sessions of stereotactic radiosurgery with good control of his brain disease. " ], "offsets": [ [ 0, 192 ] ] }, { "id": "4879", "type": "abstract", "text": [ "Extracranial metastases from brain meningiomas is a rare, but well-documented entity. " ], "offsets": [ [ 193, 279 ] ] }, { "id": "4880", "type": "abstract", "text": [ "Extraneural metastases from cranial meningioma: a case report. " ], "offsets": [ [ 280, 344 ] ] } ]

[ { "id": "4881", "type": "Diseases", "text": [ "meningioma" ], "offsets": [ [ 66, 76 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d104.s0.e0" } ] }, { "id": "4882", "type": "Diseases", "text": [ "brain disease" ], "offsets": [ [ 177, 190 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d104.s0.e1" } ] }, { "id": "4883", "type": "Species", "text": [ "patient" ], "offsets": [ [ 20, 27 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d104.s0.e2" } ] }, { "id": "4884", "type": "Diseases", "text": [ "meningiomas" ], "offsets": [ [ 228, 239 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d104.s2.e0" } ] }, { "id": "4885", "type": "Diseases", "text": [ "cranial meningioma" ], "offsets": [ [ 308, 326 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d104.s4.e0" } ] } ]

[]

[]

[]

[ { "id": "4887", "type": "title", "text": [ "The present review examines the various miRNAs that have been identified as being potentially involved in T2D, focusing on the insulin-sensitive organs: white adipose tissue, liver, skeletal muscle and the insulin-producing pancreatic β-cells. " ], "offsets": [ [ 0, 246 ] ] }, { "id": "4888", "type": "abstract", "text": [ "miRNAs are involved in a large number of biological functions such as development, metabolism, immunity and diseases such as cancer, cardiovascular diseases and diabetes. " ], "offsets": [ [ 247, 418 ] ] }, { "id": "4889", "type": "abstract", "text": [ "miRNAs are small 22-25-nt-long untranslated RNAs that negatively regulate the translation of mRNAs. " ], "offsets": [ [ 419, 519 ] ] }, { "id": "4890", "type": "abstract", "text": [ "Although T2D seems to be strongly linked to environmental factors such as nutrition and lifestyle, studies have shown that genetic factors, such as polymorphisms associated with metabolic genes, imprinting, fetal programming and miRNA (microRNA) expression, could also contribute to the development of this disease. " ], "offsets": [ [ 520, 836 ] ] }, { "id": "4891", "type": "abstract", "text": [ "The aetiology and molecular mechanisms of T2D are not fully understood, but compelling evidence points to a link between T2D, obesity, dyslipidaemia and insulin resistance. " ], "offsets": [ [ 837, 1010 ] ] }, { "id": "4892", "type": "abstract", "text": [ "Improper treatment of TD2 can lead to severe complications such as heart disease, stroke, kidney failure, blindness and nerve damage. " ], "offsets": [ [ 1011, 1145 ] ] }, { "id": "4893", "type": "abstract", "text": [ "T2D is a progressive metabolic disorder characterized by reduced insulin sensitivity, insulin resistance and pancreatic β-cell dysfunction. " ], "offsets": [ [ 1146, 1286 ] ] }, { "id": "4894", "type": "abstract", "text": [ "The involvement of microRNAs in Type 2 diabetes. " ], "offsets": [ [ 1287, 1337 ] ] }, { "id": "4895", "type": "abstract", "text": [ "T2D (Type 2 diabetes mellitus) is a major health issue that has reached epidemic status worldwide. " ], "offsets": [ [ 1338, 1437 ] ] } ]

[ { "id": "4896", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 40, 46 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d105.s0.e0" } ] }, { "id": "4897", "type": "Diseases", "text": [ "T2D" ], "offsets": [ [ 106, 109 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d105.s0.e1" } ] }, { "id": "4898", "type": "Genes/Proteins", "text": [ "insulin" ], "offsets": [ [ 127, 134 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d105.s0.e2" } ] }, { "id": "4899", "type": "Genes/Proteins", "text": [ "insulin" ], "offsets": [ [ 206, 213 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d105.s0.e3" } ] }, { "id": "4900", "type": "Diseases", "text": [ "cardiovascular diseases" ], "offsets": [ [ 380, 403 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d105.s1.e0" } ] }, { "id": "4901", "type": "Diseases", "text": [ "diabetes" ], "offsets": [ [ 408, 416 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d105.s1.e1" } ] }, { "id": "4902", "type": "Diseases", "text": [ "cancer" ], "offsets": [ [ 372, 378 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d105.s1.e2" } ] }, { "id": "4903", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 247, 253 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d105.s1.e3" } ] }, { "id": "4904", "type": "Relation_Trigger", "text": [ "regulate the translation" ], "offsets": [ [ 484, 508 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d105.s2.e0" } ] }, { "id": "4905", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 419, 425 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d105.s2.e1" } ] }, { "id": "4906", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 749, 754 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d105.s3.e0" } ] }, { "id": "4907", "type": "Non-Specific_miRNAs", "text": [ "microRNA" ], "offsets": [ [ 756, 764 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d105.s3.e1" } ] }, { "id": "4908", "type": "Diseases", "text": [ "T2D" ], "offsets": [ [ 529, 532 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d105.s3.e2" } ] }, { "id": "4909", "type": "Relation_Trigger", "text": [ "associated" ], "offsets": [ [ 682, 692 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d105.s3.e3" } ] }, { "id": "4910", "type": "Diseases", "text": [ "T2D" ], "offsets": [ [ 879, 882 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d105.s4.e0" } ] }, { "id": "4911", "type": "Diseases", "text": [ "T2D" ], "offsets": [ [ 958, 961 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d105.s4.e1" } ] }, { "id": "4912", "type": "Diseases", "text": [ "obesity" ], "offsets": [ [ 963, 970 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d105.s4.e2" } ] }, { "id": "4913", "type": "Diseases", "text": [ "dyslipidaemia" ], "offsets": [ [ 972, 985 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d105.s4.e3" } ] }, { "id": "4914", "type": "Diseases", "text": [ "insulin resistance" ], "offsets": [ [ 990, 1008 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d105.s4.e4" } ] }, { "id": "4915", "type": "Diseases", "text": [ "TD2" ], "offsets": [ [ 1033, 1036 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d105.s5.e0" } ] }, { "id": "4916", "type": "Diseases", "text": [ "heart disease" ], "offsets": [ [ 1078, 1091 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d105.s5.e1" } ] }, { "id": "4917", "type": "Diseases", "text": [ "stroke" ], "offsets": [ [ 1093, 1099 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d105.s5.e2" } ] }, { "id": "4918", "type": "Diseases", "text": [ "kidney failure" ], "offsets": [ [ 1101, 1115 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d105.s5.e3" } ] }, { "id": "4919", "type": "Diseases", "text": [ "blindness" ], "offsets": [ [ 1117, 1126 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d105.s5.e4" } ] }, { "id": "4920", "type": "Diseases", "text": [ "nerve damage" ], "offsets": [ [ 1131, 1143 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d105.s5.e5" } ] }, { "id": "4921", "type": "Diseases", "text": [ "T2D" ], "offsets": [ [ 1146, 1149 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d105.s6.e0" } ] }, { "id": "4922", "type": "Genes/Proteins", "text": [ "insulin" ], "offsets": [ [ 1211, 1218 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d105.s6.e1" } ] }, { "id": "4923", "type": "Diseases", "text": [ "insulin resistance" ], "offsets": [ [ 1232, 1250 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d105.s6.e2" } ] }, { "id": "4924", "type": "Diseases", "text": [ "pancreatic β-cell dysfunction" ], "offsets": [ [ 1255, 1284 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d105.s6.e3" } ] }, { "id": "4925", "type": "Non-Specific_miRNAs", "text": [ "microRNAs" ], "offsets": [ [ 1306, 1315 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d105.s7.e0" } ] }, { "id": "4926", "type": "Diseases", "text": [ "Type 2 diabetes" ], "offsets": [ [ 1319, 1334 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d105.s7.e1" } ] }, { "id": "4927", "type": "Diseases", "text": [ "T2D" ], "offsets": [ [ 1338, 1341 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d105.s8.e0" } ] }, { "id": "4928", "type": "Diseases", "text": [ "Type 2 diabetes mellitus" ], "offsets": [ [ 1343, 1367 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d105.s8.e1" } ] } ]

[]

[]

[ { "id": "4929", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d105.s0.e0", "arg2_id": "miRNA-corp.d105.s0.e1", "normalized": [] }, { "id": "4930", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d105.s0.e0", "arg2_id": "miRNA-corp.d105.s0.e2", "normalized": [] }, { "id": "4931", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d105.s0.e0", "arg2_id": "miRNA-corp.d105.s0.e3", "normalized": [] }, { "id": "4932", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d105.s1.e3", "arg2_id": "miRNA-corp.d105.s1.e0", "normalized": [] }, { "id": "4933", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d105.s1.e3", "arg2_id": "miRNA-corp.d105.s1.e1", "normalized": [] }, { "id": "4934", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d105.s1.e3", "arg2_id": "miRNA-corp.d105.s1.e2", "normalized": [] }, { "id": "4935", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d105.s3.e0", "arg2_id": "miRNA-corp.d105.s3.e2", "normalized": [] }, { "id": "4936", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d105.s3.e1", "arg2_id": "miRNA-corp.d105.s3.e2", "normalized": [] }, { "id": "4937", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d105.s7.e0", "arg2_id": "miRNA-corp.d105.s7.e1", "normalized": [] } ]

[ { "id": "4939", "type": "title", "text": [ "Isolation and characterization of a novel pituitary tumor apoptosis gene. " ], "offsets": [ [ 0, 75 ] ] }, { "id": "4940", "type": "abstract", "text": [ "We report the isolation of a novel differentially methylated chromosome 22 CpG island-associated gene (C22orf3). " ], "offsets": [ [ 76, 189 ] ] }, { "id": "4941", "type": "abstract", "text": [ "Sodium bisulfite sequencing of individual adenomas showed that 6 of 30 (20%) that failed to express pituitary tumor apoptosis gene (PTAG) were methylated; however, genetic change as determined by loss of heterozygosity and sequence analysis was not apparent in the remaining tumors that failed to express this gene. " ], "offsets": [ [ 190, 506 ] ] }, { "id": "4942", "type": "abstract", "text": [ "Sodium bisulfite sequencing of pooled tumor cohorts, used in the isolation of this gene, showed that only a proportion of the adenomas within the pools were methylated; however, expression analysis by quantitative RT-PCR of individual adenoma irrespective of subtype showed the majority (30 of 38; 79%) failed to express this gene relative to normal pituitary. " ], "offsets": [ [ 507, 868 ] ] }, { "id": "4943", "type": "abstract", "text": [ "Enforced expression of C22orf3 in AtT20 cells had no measurable effects on cell proliferation or viability; however, in response to bromocriptine challenge (10-40 microm) cells expressing this gene showed a significantly augmented apoptotic response as determined by both acridine orange staining and TUNEL labeling. " ], "offsets": [ [ 869, 1186 ] ] }, { "id": "4944", "type": "abstract", "text": [ "In those cases where the CpG island of these genes was methylated it was invariably associated with loss of transcript expression. " ], "offsets": [ [ 1187, 1318 ] ] }, { "id": "4945", "type": "abstract", "text": [ "In addition, in time course experiments, direct measurement of active caspases by fluorochrome-labeled inhibition of caspases, showed an augmented increase (approximately 2.4 fold) in active caspases in response to bromocriptine challenge in cells expressing C22orf3 relative to those harboring an empty vector control. " ], "offsets": [ [ 1319, 1639 ] ] }, { "id": "4946", "type": "abstract", "text": [ "The apoptotic response to bromocriptine challenge was inhibited in coincubation experiments with the general caspase inhibitor z-VAD-fmk. " ], "offsets": [ [ 1640, 1778 ] ] }, { "id": "4947", "type": "abstract", "text": [ "The pituitary tumor derivation and its role in apoptosis of this gene led us to assign the acronym PTAG to this gene and its protein product. " ], "offsets": [ [ 1779, 1921 ] ] }, { "id": "4948", "type": "abstract", "text": [ "The ability of cells, showing reduced expression of PTAG, to evade or show a blunted apoptotic response may underlie oncogenic transformation in both the pituitary and other tumor types. " ], "offsets": [ [ 1922, 2111 ] ] } ]

[ { "id": "4949", "type": "Genes/Proteins", "text": [ "pituitary tumor apoptosis gene" ], "offsets": [ [ 42, 72 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d106.s0.e0" } ] }, { "id": "4950", "type": "Genes/Proteins", "text": [ "C22orf3" ], "offsets": [ [ 179, 186 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d106.s1.e0" } ] }, { "id": "4951", "type": "Relation_Trigger", "text": [ "failed to express" ], "offsets": [ [ 272, 289 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d106.s3.e0" } ] }, { "id": "4952", "type": "Relation_Trigger", "text": [ "failed to express" ], "offsets": [ [ 477, 494 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d106.s3.e1" } ] }, { "id": "4953", "type": "Genes/Proteins", "text": [ "pituitary tumor apoptosis gene" ], "offsets": [ [ 290, 320 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d106.s3.e2" } ] }, { "id": "4954", "type": "Genes/Proteins", "text": [ "PTAG" ], "offsets": [ [ 322, 326 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d106.s3.e3" } ] }, { "id": "4955", "type": "Diseases", "text": [ "tumors" ], "offsets": [ [ 465, 471 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d106.s3.e4" } ] }, { "id": "4956", "type": "Diseases", "text": [ "adenomas" ], "offsets": [ [ 232, 240 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d106.s3.e5" } ] }, { "id": "4957", "type": "Diseases", "text": [ "tumor" ], "offsets": [ [ 545, 550 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d106.s4.e0" } ] }, { "id": "4958", "type": "Relation_Trigger", "text": [ "failed to express" ], "offsets": [ [ 810, 827 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d106.s4.e1" } ] }, { "id": "4959", "type": "Diseases", "text": [ "adenomas" ], "offsets": [ [ 633, 641 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d106.s4.e2" } ] }, { "id": "4960", "type": "Diseases", "text": [ "adenoma" ], "offsets": [ [ 742, 749 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d106.s4.e3" } ] }, { "id": "4961", "type": "Genes/Proteins", "text": [ "C22orf3" ], "offsets": [ [ 892, 899 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d106.s5.e0" } ] }, { "id": "4962", "type": "Relation_Trigger", "text": [ "loss of transcript expression" ], "offsets": [ [ 1287, 1316 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d106.s6.e0" } ] }, { "id": "4963", "type": "Relation_Trigger", "text": [ "associated" ], "offsets": [ [ 1271, 1281 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d106.s6.e1" } ] }, { "id": "4964", "type": "Relation_Trigger", "text": [ "inhibition" ], "offsets": [ [ 1422, 1432 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d106.s7.e0" } ] }, { "id": "4965", "type": "Genes/Proteins", "text": [ "C22orf3" ], "offsets": [ [ 1578, 1585 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d106.s7.e1" } ] }, { "id": "4966", "type": "Relation_Trigger", "text": [ "inhibited" ], "offsets": [ [ 1694, 1703 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d106.s8.e0" } ] }, { "id": "4967", "type": "Relation_Trigger", "text": [ "inhibitor" ], "offsets": [ [ 1757, 1766 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d106.s8.e1" } ] }, { "id": "4968", "type": "Genes/Proteins", "text": [ "PTAG" ], "offsets": [ [ 1878, 1882 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d106.s9.e0" } ] }, { "id": "4969", "type": "Diseases", "text": [ "pituitary tumor" ], "offsets": [ [ 1783, 1798 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d106.s9.e1" } ] }, { "id": "4970", "type": "Genes/Proteins", "text": [ "PTAG" ], "offsets": [ [ 1974, 1978 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d106.s10.e0" } ] }, { "id": "4971", "type": "Diseases", "text": [ "tumor" ], "offsets": [ [ 2096, 2101 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d106.s10.e1" } ] }, { "id": "4972", "type": "Relation_Trigger", "text": [ "reduced expression" ], "offsets": [ [ 1952, 1970 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d106.s10.e2" } ] } ]

[]

[]

[]

[ { "id": "4974", "type": "title", "text": [ "Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression. " ], "offsets": [ [ 0, 129 ] ] }, { "id": "4975", "type": "abstract", "text": [ "Although the role of APP and PSEN genes in genetic Alzheimer's disease (AD) cases is well established, fairly little is known about the molecular mechanisms affecting Abeta generation in sporadic AD. Deficiency in Abeta clearance is certainly a possibility, but increased expression of proteins like APP or BACE1/beta-secretase may also be associated with the disease. " ], "offsets": [ [ 130, 499 ] ] }, { "id": "4976", "type": "abstract", "text": [ "We therefore investigated changes in microRNA (miRNA) expression profiles of sporadic AD patients and found that several miRNAs potentially involved in the regulation of APP and BACE1 expression appeared to be decreased in diseased brain. " ], "offsets": [ [ 500, 739 ] ] }, { "id": "4977", "type": "abstract", "text": [ "We show here that miR-29a, -29b-1, and -9 can regulate BACE1 expression in vitro. " ], "offsets": [ [ 740, 822 ] ] }, { "id": "4978", "type": "abstract", "text": [ "The miR-29a/b-1 cluster was significantly (and AD-dementia-specific) decreased in AD patients displaying abnormally high BACE1 protein. " ], "offsets": [ [ 823, 959 ] ] }, { "id": "4979", "type": "abstract", "text": [ "Similar correlations between expression of this cluster and BACE1 were found during brain development and in primary neuronal cultures. " ], "offsets": [ [ 960, 1096 ] ] }, { "id": "4980", "type": "abstract", "text": [ "Finally, we provide evidence for a potential causal relationship between miR-29a/b-1 expression and Abeta generation in a cell culture model. " ], "offsets": [ [ 1097, 1239 ] ] }, { "id": "4981", "type": "abstract", "text": [ "We propose that loss of specific miRNAs can contribute to increased BACE1 and Abeta levels in sporadic AD. " ], "offsets": [ [ 1240, 1349 ] ] } ]

[ { "id": "4982", "type": "Specific_miRNAs", "text": [ "miR-29a/b-1" ], "offsets": [ [ 25, 36 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d107.s0.e0" } ] }, { "id": "4983", "type": "Genes/Proteins", "text": [ "BACE1" ], "offsets": [ [ 95, 100 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d107.s0.e1" } ] }, { "id": "4984", "type": "Non-Specific_miRNAs", "text": [ "microRNA" ], "offsets": [ [ 8, 16 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d107.s0.e2" } ] }, { "id": "4985", "type": "Relation_Trigger", "text": [ "Loss of microRNA cluster" ], "offsets": [ [ 0, 24 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d107.s0.e3" } ] }, { "id": "4986", "type": "Relation_Trigger", "text": [ "increased BACE1/beta-secretase expression" ], "offsets": [ [ 85, 126 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d107.s0.e4" } ] }, { "id": "4987", "type": "Diseases", "text": [ "sporadic Alzheimer's disease" ], "offsets": [ [ 40, 68 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d107.s0.e5" } ] }, { "id": "4988", "type": "Genes/Proteins", "text": [ "beta-secretase" ], "offsets": [ [ 101, 115 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d107.s0.e6" } ] }, { "id": "4989", "type": "Relation_Trigger", "text": [ "correlates" ], "offsets": [ [ 69, 79 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d107.s0.e7" } ] }, { "id": "4990", "type": "Genes/Proteins", "text": [ "APP" ], "offsets": [ [ 151, 154 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d107.s1.e0" } ] }, { "id": "4991", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 202, 204 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d107.s1.e1" } ] }, { "id": "4992", "type": "Genes/Proteins", "text": [ "Abeta" ], "offsets": [ [ 297, 302 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d107.s1.e2" } ] }, { "id": "4993", "type": "Genes/Proteins", "text": [ "Abeta" ], "offsets": [ [ 344, 349 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d107.s1.e3" } ] }, { "id": "4994", "type": "Genes/Proteins", "text": [ "APP" ], "offsets": [ [ 430, 433 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d107.s1.e4" } ] }, { "id": "4995", "type": "Genes/Proteins", "text": [ "BACE1" ], "offsets": [ [ 437, 442 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d107.s1.e5" } ] }, { "id": "4996", "type": "Diseases", "text": [ "sporadic AD" ], "offsets": [ [ 317, 328 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d107.s1.e6" } ] }, { "id": "4997", "type": "Diseases", "text": [ "genetic Alzheimer's disease" ], "offsets": [ [ 173, 200 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d107.s1.e7" } ] }, { "id": "4998", "type": "Relation_Trigger", "text": [ "increased expression" ], "offsets": [ [ 392, 412 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d107.s1.e8" } ] }, { "id": "4999", "type": "Relation_Trigger", "text": [ "associated" ], "offsets": [ [ 470, 480 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d107.s1.e9" } ] }, { "id": "5000", "type": "Genes/Proteins", "text": [ "beta-secretase" ], "offsets": [ [ 443, 457 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d107.s1.e10" } ] }, { "id": "5001", "type": "Genes/Proteins", "text": [ "APP" ], "offsets": [ [ 670, 673 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d107.s2.e0" } ] }, { "id": "5002", "type": "Genes/Proteins", "text": [ "BACE1" ], "offsets": [ [ 678, 683 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d107.s2.e1" } ] }, { "id": "5003", "type": "Non-Specific_miRNAs", "text": [ "microRNA" ], "offsets": [ [ 537, 545 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d107.s2.e2" } ] }, { "id": "5004", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 547, 552 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d107.s2.e3" } ] }, { "id": "5005", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 621, 627 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d107.s2.e4" } ] }, { "id": "5006", "type": "Diseases", "text": [ "sporadic AD" ], "offsets": [ [ 577, 588 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d107.s2.e5" } ] }, { "id": "5007", "type": "Relation_Trigger", "text": [ "changes in microRNA (miRNA) expression" ], "offsets": [ [ 526, 564 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d107.s2.e6" } ] }, { "id": "5008", "type": "Relation_Trigger", "text": [ "regulation" ], "offsets": [ [ 656, 666 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d107.s2.e7" } ] }, { "id": "5009", "type": "Relation_Trigger", "text": [ "expression appeared to be decreased" ], "offsets": [ [ 684, 719 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d107.s2.e8" } ] }, { "id": "5010", "type": "Species", "text": [ "patients" ], "offsets": [ [ 589, 597 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d107.s2.e9" } ] }, { "id": "5011", "type": "Genes/Proteins", "text": [ "BACE1" ], "offsets": [ [ 795, 800 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d107.s3.e0" } ] }, { "id": "5012", "type": "Relation_Trigger", "text": [ "regulate BACE1 expression" ], "offsets": [ [ 786, 811 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d107.s3.e1" } ] }, { "id": "5013", "type": "Specific_miRNAs", "text": [ "miR-29a, -29b-1, and -9" ], "offsets": [ [ 758, 781 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d107.s3.e2" } ] }, { "id": "5014", "type": "Genes/Proteins", "text": [ "BACE1" ], "offsets": [ [ 944, 949 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d107.s4.e0" } ] }, { "id": "5015", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 905, 907 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d107.s4.e1" } ] }, { "id": "5016", "type": "Specific_miRNAs", "text": [ "miR-29a/b-1" ], "offsets": [ [ 827, 838 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d107.s4.e2" } ] }, { "id": "5017", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 870, 872 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d107.s4.e3" } ] }, { "id": "5018", "type": "Diseases", "text": [ "dementia" ], "offsets": [ [ 873, 881 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d107.s4.e4" } ] }, { "id": "5019", "type": "Relation_Trigger", "text": [ "significantly (and AD-dementia-specific) decreased" ], "offsets": [ [ 851, 901 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d107.s4.e5" } ] }, { "id": "5020", "type": "Relation_Trigger", "text": [ "abnormally high BACE1 protein" ], "offsets": [ [ 928, 957 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d107.s4.e6" } ] }, { "id": "5021", "type": "Species", "text": [ "patients" ], "offsets": [ [ 908, 916 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d107.s4.e7" } ] }, { "id": "5022", "type": "Genes/Proteins", "text": [ "BACE1" ], "offsets": [ [ 1020, 1025 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d107.s5.e0" } ] }, { "id": "5023", "type": "Relation_Trigger", "text": [ "correlations between expression" ], "offsets": [ [ 968, 999 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d107.s5.e1" } ] }, { "id": "5024", "type": "Genes/Proteins", "text": [ "Abeta" ], "offsets": [ [ 1197, 1202 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d107.s6.e0" } ] }, { "id": "5025", "type": "Specific_miRNAs", "text": [ "miR-29a/b-1" ], "offsets": [ [ 1170, 1181 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d107.s6.e1" } ] }, { "id": "5026", "type": "Genes/Proteins", "text": [ "BACE1" ], "offsets": [ [ 1308, 1313 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d107.s7.e0" } ] }, { "id": "5027", "type": "Genes/Proteins", "text": [ "Abeta" ], "offsets": [ [ 1318, 1323 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d107.s7.e1" } ] }, { "id": "5028", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1273, 1279 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d107.s7.e2" } ] }, { "id": "5029", "type": "Relation_Trigger", "text": [ "loss of specific miRNAs" ], "offsets": [ [ 1256, 1279 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d107.s7.e3" } ] }, { "id": "5030", "type": "Relation_Trigger", "text": [ "increased BACE1 and Abeta levels" ], "offsets": [ [ 1298, 1330 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d107.s7.e4" } ] }, { "id": "5031", "type": "Diseases", "text": [ "sporadic AD" ], "offsets": [ [ 1334, 1345 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d107.s7.e5" } ] } ]

[]

[]

[ { "id": "5032", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d107.s0.e0", "arg2_id": "miRNA-corp.d107.s0.e1", "normalized": [] }, { "id": "5033", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d107.s0.e0", "arg2_id": "miRNA-corp.d107.s0.e5", "normalized": [] }, { "id": "5034", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d107.s0.e0", "arg2_id": "miRNA-corp.d107.s0.e6", "normalized": [] }, { "id": "5035", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d107.s0.e2", "arg2_id": "miRNA-corp.d107.s0.e1", "normalized": [] }, { "id": "5036", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d107.s0.e2", "arg2_id": "miRNA-corp.d107.s0.e5", "normalized": [] }, { "id": "5037", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d107.s0.e2", "arg2_id": "miRNA-corp.d107.s0.e6", "normalized": [] }, { "id": "5038", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d107.s2.e2", "arg2_id": "miRNA-corp.d107.s2.e5", "normalized": [] }, { "id": "5039", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d107.s2.e2", "arg2_id": "miRNA-corp.d107.s2.e0", "normalized": [] }, { "id": "5040", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d107.s2.e2", "arg2_id": "miRNA-corp.d107.s2.e1", "normalized": [] }, { "id": "5041", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d107.s2.e3", "arg2_id": "miRNA-corp.d107.s2.e5", "normalized": [] }, { "id": "5042", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d107.s2.e3", "arg2_id": "miRNA-corp.d107.s2.e0", "normalized": [] }, { "id": "5043", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d107.s2.e3", "arg2_id": "miRNA-corp.d107.s2.e1", "normalized": [] }, { "id": "5044", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d107.s2.e4", "arg2_id": "miRNA-corp.d107.s2.e5", "normalized": [] }, { "id": "5045", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d107.s2.e4", "arg2_id": "miRNA-corp.d107.s2.e0", "normalized": [] }, { "id": "5046", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d107.s2.e4", "arg2_id": "miRNA-corp.d107.s2.e1", "normalized": [] }, { "id": "5047", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d107.s3.e2", "arg2_id": "miRNA-corp.d107.s3.e0", "normalized": [] }, { "id": "5048", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d107.s4.e2", "arg2_id": "miRNA-corp.d107.s4.e1", "normalized": [] }, { "id": "5049", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d107.s4.e2", "arg2_id": "miRNA-corp.d107.s4.e3", "normalized": [] }, { "id": "5050", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d107.s4.e2", "arg2_id": "miRNA-corp.d107.s4.e4", "normalized": [] }, { "id": "5051", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d107.s4.e2", "arg2_id": "miRNA-corp.d107.s4.e0", "normalized": [] }, { "id": "5052", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d107.s6.e1", "arg2_id": "miRNA-corp.d107.s6.e0", "normalized": [] }, { "id": "5053", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d107.s7.e2", "arg2_id": "miRNA-corp.d107.s7.e0", "normalized": [] }, { "id": "5054", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d107.s7.e2", "arg2_id": "miRNA-corp.d107.s7.e1", "normalized": [] }, { "id": "5055", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d107.s7.e2", "arg2_id": "miRNA-corp.d107.s7.e5", "normalized": [] } ]

[ { "id": "5057", "type": "title", "text": [ "Here we expand the role of GRN in FTLD-U and demonstrate that a common genetic variant (rs5848), located in the 3'-untranslated region (UTR) of GRN in a binding-site for miR-659, is a major susceptibility factor for FTLD-U. " ], "offsets": [ [ 0, 224 ] ] }, { "id": "5058", "type": "abstract", "text": [ "Loss-of-function mutations in progranulin (GRN) cause ubiquitin- and TAR DNA-binding protein 43 (TDP-43)-positive frontotemporal dementia (FTLD-U), a progressive neurodegenerative disease affecting approximately 10% of early-onset dementia patients. " ], "offsets": [ [ 225, 475 ] ] }, { "id": "5059", "type": "abstract", "text": [ "Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia. " ], "offsets": [ [ 476, 596 ] ] }, { "id": "5060", "type": "abstract", "text": [ "In support of these findings, the neuropathology of homozygous rs5848 T-allele carriers frequently resembled the pathological FTLD-U subtype of GRN mutation carriers. " ], "offsets": [ [ 597, 764 ] ] }, { "id": "5061", "type": "abstract", "text": [ "A significant reduction in GRN protein was observed in homozygous T-allele carriers in vivo, through biochemical and immunohistochemical methods, mimicking the effect of heterozygous loss-of-function GRN mutations. " ], "offsets": [ [ 765, 980 ] ] }, { "id": "5062", "type": "abstract", "text": [ "We further demonstrate that miR-659 can regulate GRN expression in vitro, with miR-659 binding more efficiently to the high risk T-allele of rs5848 resulting in augmented translational inhibition of GRN. " ], "offsets": [ [ 981, 1185 ] ] }, { "id": "5063", "type": "abstract", "text": [ "In a series of pathologically confirmed FTLD-U patients without GRN mutations, we show that carriers homozygous for the T-allele of rs5848 have a 3.2-fold increased risk to develop FTLD-U compared with homozygous C-allele carriers (95% CI: 1.50-6.73). " ], "offsets": [ [ 1186, 1438 ] ] }, { "id": "5064", "type": "abstract", "text": [ "Translational regulation by miRNAs may represent a common mechanism underlying complex neurodegenerative disorders. " ], "offsets": [ [ 1439, 1557 ] ] }, { "id": "5065", "type": "abstract", "text": [ "We suggest that the expression of GRN is regulated by miRNAs and that common genetic variability in a miRNA binding-site can significantly increase the risk for FTLD-U. " ], "offsets": [ [ 1558, 1727 ] ] } ]

[ { "id": "5066", "type": "Genes/Proteins", "text": [ "GRN" ], "offsets": [ [ 27, 30 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d108.s0.e0" } ] }, { "id": "5067", "type": "Diseases", "text": [ "FTLD-U" ], "offsets": [ [ 34, 40 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d108.s0.e1" } ] }, { "id": "5068", "type": "Genes/Proteins", "text": [ "GRN" ], "offsets": [ [ 144, 147 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d108.s0.e2" } ] }, { "id": "5069", "type": "Specific_miRNAs", "text": [ "miR-659" ], "offsets": [ [ 170, 177 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d108.s0.e3" } ] }, { "id": "5070", "type": "Diseases", "text": [ "FTLD-U" ], "offsets": [ [ 216, 222 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d108.s0.e4" } ] }, { "id": "5071", "type": "Relation_Trigger", "text": [ "binding-site" ], "offsets": [ [ 153, 165 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d108.s0.e5" } ] }, { "id": "5072", "type": "Relation_Trigger", "text": [ "binding" ], "offsets": [ [ 153, 160 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d108.s0.e6" } ] }, { "id": "5073", "type": "Genes/Proteins", "text": [ "GRN" ], "offsets": [ [ 268, 271 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d108.s1.e0" } ] }, { "id": "5074", "type": "Diseases", "text": [ "frontotemporal dementia" ], "offsets": [ [ 339, 362 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d108.s1.e1" } ] }, { "id": "5075", "type": "Diseases", "text": [ "FTLD-U" ], "offsets": [ [ 364, 370 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d108.s1.e2" } ] }, { "id": "5076", "type": "Diseases", "text": [ "early-onset dementia" ], "offsets": [ [ 444, 464 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d108.s1.e3" } ] }, { "id": "5077", "type": "Diseases", "text": [ "progressive neurodegenerative disease" ], "offsets": [ [ 375, 412 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d108.s1.e4" } ] }, { "id": "5078", "type": "Genes/Proteins", "text": [ "progranulin" ], "offsets": [ [ 255, 266 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d108.s1.e5" } ] }, { "id": "5079", "type": "Genes/Proteins", "text": [ "TAR DNA-binding protein 43" ], "offsets": [ [ 294, 320 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d108.s1.e6" } ] }, { "id": "5080", "type": "Genes/Proteins", "text": [ "TDP-43" ], "offsets": [ [ 322, 328 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d108.s1.e7" } ] }, { "id": "5081", "type": "Genes/Proteins", "text": [ "ubiquitin" ], "offsets": [ [ 279, 288 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d108.s1.e8" } ] }, { "id": "5082", "type": "Species", "text": [ "patients" ], "offsets": [ [ 465, 473 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d108.s1.e9" } ] }, { "id": "5083", "type": "Specific_miRNAs", "text": [ "miR-659" ], "offsets": [ [ 500, 507 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d108.s2.e0" } ] }, { "id": "5084", "type": "Genes/Proteins", "text": [ "GRN" ], "offsets": [ [ 524, 527 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d108.s2.e1" } ] }, { "id": "5085", "type": "Diseases", "text": [ "frontotemporal dementia" ], "offsets": [ [ 570, 593 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d108.s2.e2" } ] }, { "id": "5086", "type": "Genes/Proteins", "text": [ "TDP43" ], "offsets": [ [ 555, 560 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d108.s2.e3" } ] }, { "id": "5087", "type": "Relation_Trigger", "text": [ "binding-site" ], "offsets": [ [ 508, 520 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d108.s2.e4" } ] }, { "id": "5088", "type": "Diseases", "text": [ "FTLD-U" ], "offsets": [ [ 723, 729 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d108.s3.e0" } ] }, { "id": "5089", "type": "Genes/Proteins", "text": [ "GRN" ], "offsets": [ [ 741, 744 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d108.s3.e1" } ] }, { "id": "5090", "type": "Genes/Proteins", "text": [ "GRN" ], "offsets": [ [ 792, 795 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d108.s4.e0" } ] }, { "id": "5091", "type": "Genes/Proteins", "text": [ "GRN" ], "offsets": [ [ 965, 968 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d108.s4.e1" } ] }, { "id": "5092", "type": "Relation_Trigger", "text": [ "reduction in GRN protein" ], "offsets": [ [ 779, 803 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d108.s4.e2" } ] }, { "id": "5093", "type": "Genes/Proteins", "text": [ "GRN" ], "offsets": [ [ 1180, 1183 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d108.s5.e0" } ] }, { "id": "5094", "type": "Genes/Proteins", "text": [ "GRN" ], "offsets": [ [ 1030, 1033 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d108.s5.e1" } ] }, { "id": "5095", "type": "Specific_miRNAs", "text": [ "miR-659" ], "offsets": [ [ 1060, 1067 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d108.s5.e2" } ] }, { "id": "5096", "type": "Specific_miRNAs", "text": [ "miR-659" ], "offsets": [ [ 1009, 1016 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d108.s5.e3" } ] }, { "id": "5097", "type": "Relation_Trigger", "text": [ "translational inhibition" ], "offsets": [ [ 1152, 1176 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d108.s5.e4" } ] }, { "id": "5098", "type": "Relation_Trigger", "text": [ "regulate GRN expression" ], "offsets": [ [ 1021, 1044 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d108.s5.e5" } ] }, { "id": "5099", "type": "Relation_Trigger", "text": [ "binding" ], "offsets": [ [ 1068, 1075 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d108.s5.e6" } ] }, { "id": "5100", "type": "Diseases", "text": [ "FTLD-U" ], "offsets": [ [ 1226, 1232 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d108.s6.e0" } ] }, { "id": "5101", "type": "Diseases", "text": [ "FTLD-U" ], "offsets": [ [ 1367, 1373 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d108.s6.e1" } ] }, { "id": "5102", "type": "Genes/Proteins", "text": [ "GRN" ], "offsets": [ [ 1250, 1253 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d108.s6.e2" } ] }, { "id": "5103", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1233, 1241 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d108.s6.e3" } ] }, { "id": "5104", "type": "Relation_Trigger", "text": [ "Translational regulation" ], "offsets": [ [ 1439, 1463 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d108.s7.e0" } ] }, { "id": "5105", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1467, 1473 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d108.s7.e1" } ] }, { "id": "5106", "type": "Diseases", "text": [ "neurodegenerative disorders" ], "offsets": [ [ 1526, 1553 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d108.s7.e2" } ] }, { "id": "5107", "type": "Diseases", "text": [ "FTLD-U" ], "offsets": [ [ 1719, 1725 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d108.s8.e0" } ] }, { "id": "5108", "type": "Genes/Proteins", "text": [ "GRN" ], "offsets": [ [ 1592, 1595 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d108.s8.e1" } ] }, { "id": "5109", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1660, 1665 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d108.s8.e2" } ] }, { "id": "5110", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1612, 1618 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d108.s8.e3" } ] }, { "id": "5111", "type": "Relation_Trigger", "text": [ "expression of GRN is regulated" ], "offsets": [ [ 1578, 1608 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d108.s8.e4" } ] }, { "id": "5112", "type": "Relation_Trigger", "text": [ "significantly increase" ], "offsets": [ [ 1683, 1705 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d108.s8.e5" } ] }, { "id": "5113", "type": "Relation_Trigger", "text": [ "binding-site" ], "offsets": [ [ 1666, 1678 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d108.s8.e6" } ] } ]

[]

[]

[ { "id": "5114", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d108.s0.e3", "arg2_id": "miRNA-corp.d108.s0.e4", "normalized": [] }, { "id": "5115", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d108.s0.e3", "arg2_id": "miRNA-corp.d108.s0.e0", "normalized": [] }, { "id": "5116", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d108.s0.e3", "arg2_id": "miRNA-corp.d108.s0.e1", "normalized": [] }, { "id": "5117", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d108.s0.e3", "arg2_id": "miRNA-corp.d108.s0.e2", "normalized": [] }, { "id": "5118", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d108.s2.e0", "arg2_id": "miRNA-corp.d108.s2.e1", "normalized": [] }, { "id": "5119", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d108.s2.e0", "arg2_id": "miRNA-corp.d108.s2.e2", "normalized": [] }, { "id": "5120", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d108.s2.e0", "arg2_id": "miRNA-corp.d108.s2.e3", "normalized": [] }, { "id": "5121", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d108.s5.e2", "arg2_id": "miRNA-corp.d108.s5.e0", "normalized": [] }, { "id": "5122", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d108.s5.e2", "arg2_id": "miRNA-corp.d108.s5.e1", "normalized": [] }, { "id": "5123", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d108.s5.e3", "arg2_id": "miRNA-corp.d108.s5.e0", "normalized": [] }, { "id": "5124", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d108.s5.e3", "arg2_id": "miRNA-corp.d108.s5.e1", "normalized": [] }, { "id": "5125", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d108.s7.e1", "arg2_id": "miRNA-corp.d108.s7.e2", "normalized": [] }, { "id": "5126", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d108.s8.e2", "arg2_id": "miRNA-corp.d108.s8.e0", "normalized": [] }, { "id": "5127", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d108.s8.e2", "arg2_id": "miRNA-corp.d108.s8.e1", "normalized": [] }, { "id": "5128", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d108.s8.e3", "arg2_id": "miRNA-corp.d108.s8.e0", "normalized": [] }, { "id": "5129", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d108.s8.e3", "arg2_id": "miRNA-corp.d108.s8.e1", "normalized": [] } ]

[ { "id": "5131", "type": "title", "text": [ "Taken together, our findings indicate that miR-15b regulates cell cycle progression in glioma cells by targeting cell cycle-related molecules. " ], "offsets": [ [ 0, 145 ] ] }, { "id": "5132", "type": "abstract", "text": [ "Over-expression of miR-15b resulted in cell cycle arrest at G0/G1 phase while suppression of miR-15b expression resulted in a decrease of cell populations in G0/G1 and a corresponding increase of cell populations in S phase. " ], "offsets": [ [ 146, 371 ] ] }, { "id": "5133", "type": "abstract", "text": [ "We further showed that CCNE1 (encoding cyclin E1) is one of the downstream targets of miR-15b. " ], "offsets": [ [ 372, 467 ] ] }, { "id": "5134", "type": "abstract", "text": [ "We have recently compared the miRNA expression profiles between normal brain and glioma tissues from Chinese patients by miRNA microarray and identified a panel of differentially expressed miRNAs. " ], "offsets": [ [ 468, 665 ] ] }, { "id": "5135", "type": "abstract", "text": [ "Here, we studied the function of one miRNA, miR-15b, in glioma carcinogenesis and elucidated its downstream targets. " ], "offsets": [ [ 666, 783 ] ] }, { "id": "5136", "type": "abstract", "text": [ "MicroRNAs (miRNAs) are non-protein-coding RNAs that function as post-transcriptional gene regulators. " ], "offsets": [ [ 784, 886 ] ] }, { "id": "5137", "type": "abstract", "text": [ "Recent evidence has shown that miRNA plays a pivotal role in the development of many cancers including glioma, a lethal brain cancer. " ], "offsets": [ [ 887, 1021 ] ] }, { "id": "5138", "type": "abstract", "text": [ "MicroRNA-15b regulates cell cycle progression by targeting cyclins in glioma cells. " ], "offsets": [ [ 1022, 1107 ] ] } ]

[ { "id": "5139", "type": "Specific_miRNAs", "text": [ "miR-15b" ], "offsets": [ [ 43, 50 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d109.s0.e0" } ] }, { "id": "5140", "type": "Relation_Trigger", "text": [ "regulates" ], "offsets": [ [ 51, 60 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d109.s0.e1" } ] }, { "id": "5141", "type": "Relation_Trigger", "text": [ "targeting" ], "offsets": [ [ 103, 112 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d109.s0.e2" } ] }, { "id": "5142", "type": "Diseases", "text": [ "glioma" ], "offsets": [ [ 87, 93 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d109.s0.e3" } ] }, { "id": "5143", "type": "Specific_miRNAs", "text": [ "miR-15b" ], "offsets": [ [ 165, 172 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d109.s1.e0" } ] }, { "id": "5144", "type": "Specific_miRNAs", "text": [ "miR-15b" ], "offsets": [ [ 239, 246 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d109.s1.e1" } ] }, { "id": "5145", "type": "Relation_Trigger", "text": [ "Over-expression" ], "offsets": [ [ 146, 161 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d109.s1.e2" } ] }, { "id": "5146", "type": "Relation_Trigger", "text": [ "suppression of miR-15b expression" ], "offsets": [ [ 224, 257 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d109.s1.e3" } ] }, { "id": "5147", "type": "Specific_miRNAs", "text": [ "miR-15b" ], "offsets": [ [ 458, 465 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d109.s2.e0" } ] }, { "id": "5148", "type": "Genes/Proteins", "text": [ "CCNE1" ], "offsets": [ [ 395, 400 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d109.s2.e1" } ] }, { "id": "5149", "type": "Genes/Proteins", "text": [ "cyclin E1" ], "offsets": [ [ 411, 420 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d109.s2.e2" } ] }, { "id": "5150", "type": "Relation_Trigger", "text": [ "targets" ], "offsets": [ [ 447, 454 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d109.s2.e3" } ] }, { "id": "5151", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 498, 503 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d109.s3.e0" } ] }, { "id": "5152", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 589, 594 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d109.s3.e1" } ] }, { "id": "5153", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 657, 663 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d109.s3.e2" } ] }, { "id": "5154", "type": "Relation_Trigger", "text": [ "differentially expressed" ], "offsets": [ [ 632, 656 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d109.s3.e3" } ] }, { "id": "5155", "type": "Diseases", "text": [ "glioma" ], "offsets": [ [ 549, 555 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d109.s3.e4" } ] }, { "id": "5156", "type": "Species", "text": [ "patients" ], "offsets": [ [ 577, 585 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d109.s3.e5" } ] }, { "id": "5157", "type": "Specific_miRNAs", "text": [ "miR-15b" ], "offsets": [ [ 710, 717 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d109.s4.e0" } ] }, { "id": "5158", "type": "Diseases", "text": [ "glioma" ], "offsets": [ [ 722, 728 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d109.s4.e1" } ] }, { "id": "5159", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 703, 708 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d109.s4.e2" } ] }, { "id": "5160", "type": "Relation_Trigger", "text": [ "targets" ], "offsets": [ [ 774, 781 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d109.s4.e3" } ] }, { "id": "5161", "type": "Non-Specific_miRNAs", "text": [ "MicroRNAs" ], "offsets": [ [ 784, 793 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d109.s5.e0" } ] }, { "id": "5162", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 795, 801 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d109.s5.e1" } ] }, { "id": "5163", "type": "Relation_Trigger", "text": [ "regulators" ], "offsets": [ [ 874, 884 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d109.s5.e2" } ] }, { "id": "5164", "type": "Diseases", "text": [ "glioma" ], "offsets": [ [ 990, 996 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d109.s6.e0" } ] }, { "id": "5165", "type": "Diseases", "text": [ "brain cancer" ], "offsets": [ [ 1007, 1019 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d109.s6.e1" } ] }, { "id": "5166", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 918, 923 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d109.s6.e2" } ] }, { "id": "5167", "type": "Diseases", "text": [ "cancers" ], "offsets": [ [ 972, 979 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d109.s6.e3" } ] }, { "id": "5168", "type": "Specific_miRNAs", "text": [ "MicroRNA-15b" ], "offsets": [ [ 1022, 1034 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d109.s7.e0" } ] }, { "id": "5169", "type": "Relation_Trigger", "text": [ "regulates" ], "offsets": [ [ 1035, 1044 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d109.s7.e1" } ] }, { "id": "5170", "type": "Relation_Trigger", "text": [ "targeting" ], "offsets": [ [ 1071, 1080 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d109.s7.e2" } ] }, { "id": "5171", "type": "Diseases", "text": [ "glioma" ], "offsets": [ [ 1092, 1098 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d109.s7.e3" } ] } ]

[]

[]

[ { "id": "5172", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d109.s0.e0", "arg2_id": "miRNA-corp.d109.s0.e3", "normalized": [] }, { "id": "5173", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d109.s2.e0", "arg2_id": "miRNA-corp.d109.s2.e2", "normalized": [] }, { "id": "5174", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d109.s2.e0", "arg2_id": "miRNA-corp.d109.s2.e1", "normalized": [] }, { "id": "5175", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d109.s3.e0", "arg2_id": "miRNA-corp.d109.s3.e4", "normalized": [] }, { "id": "5176", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d109.s3.e1", "arg2_id": "miRNA-corp.d109.s3.e4", "normalized": [] }, { "id": "5177", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d109.s3.e2", "arg2_id": "miRNA-corp.d109.s3.e4", "normalized": [] }, { "id": "5178", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d109.s4.e2", "arg2_id": "miRNA-corp.d109.s4.e1", "normalized": [] }, { "id": "5179", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d109.s4.e0", "arg2_id": "miRNA-corp.d109.s4.e1", "normalized": [] }, { "id": "5180", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d109.s6.e2", "arg2_id": "miRNA-corp.d109.s6.e0", "normalized": [] }, { "id": "5181", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d109.s6.e2", "arg2_id": "miRNA-corp.d109.s6.e1", "normalized": [] }, { "id": "5182", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d109.s6.e2", "arg2_id": "miRNA-corp.d109.s6.e3", "normalized": [] }, { "id": "5183", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d109.s7.e0", "arg2_id": "miRNA-corp.d109.s7.e3", "normalized": [] } ]

[ { "id": "5185", "type": "title", "text": [ "It has been recently demonstrated that herpesviruses encode miRNAs to control the post-transcriptional regulation of expression from their own genomes and possibly that of their host, thus adding an additional layer of complexity to the physiological cross-talk between host and pathogen. " ], "offsets": [ [ 0, 289 ] ] }, { "id": "5186", "type": "abstract", "text": [ "MicroRNAs are small non-coding RNAs approximately 22 nt long that modulate gene expression in animals and plants. " ], "offsets": [ [ 290, 404 ] ] }, { "id": "5187", "type": "abstract", "text": [ "Co-expression of host and viral microRNAs in porcine dendritic cells infected by the pseudorabies virus. " ], "offsets": [ [ 405, 511 ] ] }, { "id": "5188", "type": "abstract", "text": [ "Almost 95% of reads mapped to the draft pig genome sequence and pig miRNAs previously annotated in dedicated databases were detected by sequence alignment. " ], "offsets": [ [ 512, 668 ] ] }, { "id": "5189", "type": "abstract", "text": [ "A catalogue of porcine and viral miRNAs, expressed eight hours post-infection, was established by deep sequencing. " ], "offsets": [ [ 669, 784 ] ] }, { "id": "5190", "type": "abstract", "text": [ "The present study focussed on the interactions between porcine dendritic cells (DCs) and the Pseudorabies virus (PRV), an alpha-herpesvirus causing Aujeszky's disease in pigs. " ], "offsets": [ [ 785, 961 ] ] }, { "id": "5191", "type": "abstract", "text": [ "In silico prediction allowed the identification of unknown porcine as well as of five miRNAs transcribed by the Large Latency Transcript (LLT) of PRV. " ], "offsets": [ [ 962, 1113 ] ] }, { "id": "5192", "type": "abstract", "text": [ "The gene target prediction of the viral miRNAs and the Ingenuity Pathway Analysis of differentially expressed pig miRNAs were conducted to contextualize the identified small RNA molecules and functionally characterize their involvement in the post-transcriptional regulation of gene expression. " ], "offsets": [ [ 1114, 1409 ] ] }, { "id": "5193", "type": "abstract", "text": [ "The results support a role for PRV miRNAs in the maintenance of the host cell latency state through the down-regulation of immediate-early viral genes which is similar to other herpesviruses. " ], "offsets": [ [ 1410, 1602 ] ] }, { "id": "5194", "type": "abstract", "text": [ "The differentially expressed swine miRNAs identified a unique network of target genes with highly significant functions in the development and function of the nervous system and in infectious mechanisms, suggesting that the modulation of both host and viral miRNAs is necessary for the establishment of PRV latency. " ], "offsets": [ [ 1603, 1921 ] ] } ]

[ { "id": "5195", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 60, 66 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d110.s0.e0" } ] }, { "id": "5196", "type": "Relation_Trigger", "text": [ "regulation of expression" ], "offsets": [ [ 103, 127 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d110.s0.e1" } ] }, { "id": "5197", "type": "Non-Specific_miRNAs", "text": [ "MicroRNAs" ], "offsets": [ [ 290, 299 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d110.s1.e0" } ] }, { "id": "5198", "type": "Relation_Trigger", "text": [ "modulate gene expression" ], "offsets": [ [ 356, 380 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d110.s1.e1" } ] }, { "id": "5199", "type": "Non-Specific_miRNAs", "text": [ "microRNAs" ], "offsets": [ [ 437, 446 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d110.s2.e0" } ] }, { "id": "5200", "type": "Relation_Trigger", "text": [ "Co-expression" ], "offsets": [ [ 405, 418 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d110.s2.e1" } ] }, { "id": "5201", "type": "Species", "text": [ "porcine" ], "offsets": [ [ 450, 457 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d110.s2.e2" } ] }, { "id": "5202", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 580, 586 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d110.s3.e0" } ] }, { "id": "5203", "type": "Species", "text": [ "pig" ], "offsets": [ [ 552, 555 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d110.s3.e1" } ] }, { "id": "5204", "type": "Species", "text": [ "pig" ], "offsets": [ [ 576, 579 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d110.s3.e2" } ] }, { "id": "5205", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 702, 708 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d110.s5.e0" } ] }, { "id": "5206", "type": "Diseases", "text": [ "infection" ], "offsets": [ [ 737, 746 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d110.s5.e1" } ] }, { "id": "5207", "type": "Species", "text": [ "porcine" ], "offsets": [ [ 684, 691 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d110.s5.e2" } ] }, { "id": "5208", "type": "Diseases", "text": [ "Aujeszky's disease" ], "offsets": [ [ 933, 951 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d110.s6.e0" } ] }, { "id": "5209", "type": "Species", "text": [ "pigs" ], "offsets": [ [ 955, 959 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d110.s6.e1" } ] }, { "id": "5210", "type": "Species", "text": [ "porcine" ], "offsets": [ [ 840, 847 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d110.s6.e2" } ] }, { "id": "5211", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1048, 1054 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d110.s7.e0" } ] }, { "id": "5212", "type": "Species", "text": [ "porcine" ], "offsets": [ [ 1021, 1028 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d110.s7.e1" } ] }, { "id": "5213", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1154, 1160 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d110.s8.e0" } ] }, { "id": "5214", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1228, 1234 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d110.s8.e1" } ] }, { "id": "5215", "type": "Relation_Trigger", "text": [ "target" ], "offsets": [ [ 1123, 1129 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d110.s8.e2" } ] }, { "id": "5216", "type": "Relation_Trigger", "text": [ "differentially expressed" ], "offsets": [ [ 1199, 1223 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d110.s8.e3" } ] }, { "id": "5217", "type": "Relation_Trigger", "text": [ "regulation of gene expression" ], "offsets": [ [ 1378, 1407 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d110.s8.e4" } ] }, { "id": "5218", "type": "Species", "text": [ "pig" ], "offsets": [ [ 1224, 1227 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d110.s8.e5" } ] }, { "id": "5219", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1445, 1451 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d110.s9.e0" } ] }, { "id": "5220", "type": "Relation_Trigger", "text": [ "down-regulation" ], "offsets": [ [ 1514, 1529 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d110.s9.e1" } ] }, { "id": "5221", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1638, 1644 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d110.s10.e0" } ] }, { "id": "5222", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1861, 1867 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d110.s10.e1" } ] }, { "id": "5223", "type": "Relation_Trigger", "text": [ "target" ], "offsets": [ [ 1676, 1682 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d110.s10.e2" } ] }, { "id": "5224", "type": "Relation_Trigger", "text": [ "differentially expressed" ], "offsets": [ [ 1607, 1631 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d110.s10.e3" } ] }, { "id": "5225", "type": "Relation_Trigger", "text": [ "modulation" ], "offsets": [ [ 1827, 1837 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d110.s10.e4" } ] }, { "id": "5226", "type": "Species", "text": [ "swine" ], "offsets": [ [ 1632, 1637 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d110.s10.e5" } ] } ]

[]

[]

[ { "id": "5227", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d110.s5.e0", "arg2_id": "miRNA-corp.d110.s5.e1", "normalized": [] } ]

[ { "id": "5229", "type": "title", "text": [ "An understanding of how microRNAs influence the body's response to certain drugs and how these affect the expression of microRNAs, will be of key importance in developing drugs with greater safety and efficacy. " ], "offsets": [ [ 0, 213 ] ] }, { "id": "5230", "type": "abstract", "text": [ "MicroRNAs (miRNAs) are short non-coding RNAs involved in post-transcriptional regulation of gene expression. " ], "offsets": [ [ 214, 323 ] ] }, { "id": "5231", "type": "abstract", "text": [ "Since the discovery of the first miRNA gene lin-4 in C. elegans, over 500 miRNAs have been identified in humans and the list is growing. " ], "offsets": [ [ 324, 461 ] ] }, { "id": "5232", "type": "abstract", "text": [ "Their biological importance, initially demonstrated in cancer, was also more recently discovered in many other pathologies like Alzheimer's disease, Parkinson's disease, viral infections, diabetes, and myopathies. " ], "offsets": [ [ 462, 676 ] ] }, { "id": "5233", "type": "abstract", "text": [ "In the present review we will summarize miRNA profiling studies in human diseases and discuss the newly discovered link between microRNAs and drug response. " ], "offsets": [ [ 677, 834 ] ] }, { "id": "5234", "type": "abstract", "text": [ "MicroRNAs in diseases and drug response. " ], "offsets": [ [ 835, 877 ] ] } ]

[ { "id": "5235", "type": "Non-Specific_miRNAs", "text": [ "microRNAs" ], "offsets": [ [ 24, 33 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d111.s0.e0" } ] }, { "id": "5236", "type": "Non-Specific_miRNAs", "text": [ "microRNAs" ], "offsets": [ [ 120, 129 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d111.s0.e1" } ] }, { "id": "5237", "type": "Relation_Trigger", "text": [ "affect the expression" ], "offsets": [ [ 95, 116 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d111.s0.e2" } ] }, { "id": "5238", "type": "Non-Specific_miRNAs", "text": [ "MicroRNAs" ], "offsets": [ [ 214, 223 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d111.s1.e0" } ] }, { "id": "5239", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 225, 231 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d111.s1.e1" } ] }, { "id": "5240", "type": "Relation_Trigger", "text": [ "regulation of gene expression" ], "offsets": [ [ 292, 321 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d111.s1.e2" } ] }, { "id": "5241", "type": "Specific_miRNAs", "text": [ "lin-4" ], "offsets": [ [ 368, 373 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d111.s2.e0" } ] }, { "id": "5242", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 357, 362 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d111.s2.e1" } ] }, { "id": "5243", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 398, 404 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d111.s2.e2" } ] }, { "id": "5244", "type": "Species", "text": [ "C. elegans" ], "offsets": [ [ 377, 387 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d111.s2.e3" } ] }, { "id": "5245", "type": "Species", "text": [ "humans" ], "offsets": [ [ 429, 435 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d111.s2.e4" } ] }, { "id": "5246", "type": "Diseases", "text": [ "Alzheimer's disease" ], "offsets": [ [ 590, 609 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d111.s3.e0" } ] }, { "id": "5247", "type": "Diseases", "text": [ "Parkinson's disease" ], "offsets": [ [ 611, 630 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d111.s3.e1" } ] }, { "id": "5248", "type": "Diseases", "text": [ "viral infections" ], "offsets": [ [ 632, 648 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d111.s3.e2" } ] }, { "id": "5249", "type": "Diseases", "text": [ "diabetes" ], "offsets": [ [ 650, 658 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d111.s3.e3" } ] }, { "id": "5250", "type": "Diseases", "text": [ "myopathies" ], "offsets": [ [ 664, 674 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d111.s3.e4" } ] }, { "id": "5251", "type": "Diseases", "text": [ "cancer" ], "offsets": [ [ 517, 523 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d111.s3.e5" } ] }, { "id": "5252", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 717, 722 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d111.s4.e0" } ] }, { "id": "5253", "type": "Non-Specific_miRNAs", "text": [ "microRNAs" ], "offsets": [ [ 805, 814 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d111.s4.e1" } ] }, { "id": "5254", "type": "Species", "text": [ "human" ], "offsets": [ [ 744, 749 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d111.s4.e2" } ] }, { "id": "5255", "type": "Non-Specific_miRNAs", "text": [ "MicroRNAs" ], "offsets": [ [ 835, 844 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d111.s5.e0" } ] } ]

[]

[]

[]

[ { "id": "5257", "type": "abstract", "text": [ "These cancers are thought to be linked to indirect radiation-induced bystander effect. " ], "offsets": [ [ 0, 87 ] ] }, { "id": "5258", "type": "abstract", "text": [ "Radiation therapy is a primary treatment modality for brain tumors, yet it has been linked to the increased incidence of secondary, post-radiation therapy cancers. " ], "offsets": [ [ 88, 252 ] ] }, { "id": "5259", "type": "abstract", "text": [ "To investigate the possibility that localized X-ray irradiation induces persistent bystander effects in distant tissue, we monitored the induction of epigenetic changes (i.e. alterations in DNA methylation, histone methylation and microRNA (miRNA) expression) in the rat spleen tissue 24 h and 7 months after localized cranial exposure to 20 Gy of X-rays. " ], "offsets": [ [ 253, 609 ] ] }, { "id": "5260", "type": "abstract", "text": [ "Further, irradiation significantly altered expression of miR-194, a miRNA putatively targeting both DNA methyltransferase-3a and MeCP2. " ], "offsets": [ [ 610, 746 ] ] }, { "id": "5261", "type": "abstract", "text": [ "Specifically, this exposure caused the profound epigenetic dysregulation in the bystander spleen tissue that manifested as a significant loss of global DNA methylation, alterations in methylation of long interspersed nucleotide element-1 (LINE-1) retrotransposable elements and down-regulation of DNA methyltransferases and methyl-binding protein methyl CpG binding protein 2 (MeCP2). " ], "offsets": [ [ 747, 1132 ] ] }, { "id": "5262", "type": "abstract", "text": [ "This study is the first to report conclusive evidence of the long-term persistence of bystander effects in radiation carcinogenesis target organ (spleen) upon localized distant exposure using the doses comparable with those used for clinical brain tumor treatments. " ], "offsets": [ [ 1133, 1401 ] ] } ]

[ { "id": "5263", "type": "Diseases", "text": [ "cancers" ], "offsets": [ [ 6, 13 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d112.s1.e0" } ] }, { "id": "5264", "type": "Diseases", "text": [ "brain tumors" ], "offsets": [ [ 142, 154 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d112.s2.e0" } ] }, { "id": "5265", "type": "Diseases", "text": [ "cancers" ], "offsets": [ [ 243, 250 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d112.s2.e1" } ] }, { "id": "5266", "type": "Non-Specific_miRNAs", "text": [ "microRNA" ], "offsets": [ [ 484, 492 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d112.s6.e0" } ] }, { "id": "5267", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 494, 499 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d112.s6.e1" } ] }, { "id": "5268", "type": "Species", "text": [ "rat" ], "offsets": [ [ 520, 523 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d112.s6.e2" } ] }, { "id": "5269", "type": "Specific_miRNAs", "text": [ "miR-194" ], "offsets": [ [ 667, 674 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d112.s7.e0" } ] }, { "id": "5270", "type": "Genes/Proteins", "text": [ "MeCP2" ], "offsets": [ [ 739, 744 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d112.s7.e1" } ] }, { "id": "5271", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 678, 683 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d112.s7.e2" } ] }, { "id": "5272", "type": "Relation_Trigger", "text": [ "targeting" ], "offsets": [ [ 695, 704 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d112.s7.e3" } ] }, { "id": "5273", "type": "Relation_Trigger", "text": [ "altered expression" ], "offsets": [ [ 645, 663 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d112.s7.e4" } ] }, { "id": "5274", "type": "Genes/Proteins", "text": [ "MeCP2" ], "offsets": [ [ 1124, 1129 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d112.s8.e0" } ] }, { "id": "5275", "type": "Relation_Trigger", "text": [ "dysregulation" ], "offsets": [ [ 806, 819 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d112.s8.e1" } ] }, { "id": "5276", "type": "Relation_Trigger", "text": [ "down-regulation" ], "offsets": [ [ 1025, 1040 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d112.s8.e2" } ] }, { "id": "5277", "type": "Genes/Proteins", "text": [ "methyl CpG binding protein 2" ], "offsets": [ [ 1094, 1122 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d112.s8.e3" } ] }, { "id": "5278", "type": "Diseases", "text": [ "brain tumor" ], "offsets": [ [ 1375, 1386 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d112.s9.e0" } ] }, { "id": "5279", "type": "Relation_Trigger", "text": [ "target" ], "offsets": [ [ 1265, 1271 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d112.s9.e1" } ] } ]

[]

[]

[ { "id": "5280", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d112.s7.e0", "arg2_id": "miRNA-corp.d112.s7.e1", "normalized": [] }, { "id": "5281", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d112.s7.e2", "arg2_id": "miRNA-corp.d112.s7.e1", "normalized": [] } ]

[ { "id": "5283", "type": "abstract", "text": [ "Furthermore, we demonstrate that miRNAs can be isolated and profiled from formalin-fixed paraffin-embedded tissue, which opens up new opportunities for analyses of small RNAs from archival human tissue. " ], "offsets": [ [ 0, 203 ] ] }, { "id": "5284", "type": "abstract", "text": [ "We show that the RAKE assay is sensitive and specific for miRNAs and is ideally suited for rapid expression profiling of all known miRNAs. " ], "offsets": [ [ 204, 343 ] ] }, { "id": "5285", "type": "abstract", "text": [ "We used RAKE to study human cell lines and brain tumors. " ], "offsets": [ [ 344, 401 ] ] }, { "id": "5286", "type": "abstract", "text": [ "The technique is termed the RNA-primed, array-based Klenow enzyme (RAKE) assay, because it involves on-slide application of the Klenow fragment of DNA polymerase I to extend unmodified miRNAs hybridized to immobilized DNA probes. " ], "offsets": [ [ 402, 632 ] ] }, { "id": "5287", "type": "abstract", "text": [ "We describe a new method for high-throughput miRNA detection. " ], "offsets": [ [ 633, 695 ] ] }, { "id": "5288", "type": "abstract", "text": [ "MicroRNAs (miRNAs) are small regulatory RNAs that serve fundamental biological roles across eukaryotic species. " ], "offsets": [ [ 696, 808 ] ] }, { "id": "5289", "type": "abstract", "text": [ "Microarray-based, high-throughput gene expression profiling of microRNAs. " ], "offsets": [ [ 809, 884 ] ] } ]

[ { "id": "5290", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 33, 39 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d113.s1.e0" } ] }, { "id": "5291", "type": "Species", "text": [ "human" ], "offsets": [ [ 189, 194 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d113.s1.e1" } ] }, { "id": "5292", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 262, 268 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d113.s3.e0" } ] }, { "id": "5293", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 335, 341 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d113.s3.e1" } ] }, { "id": "5294", "type": "Diseases", "text": [ "brain tumors" ], "offsets": [ [ 387, 399 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d113.s4.e0" } ] }, { "id": "5295", "type": "Species", "text": [ "human" ], "offsets": [ [ 366, 371 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d113.s4.e1" } ] }, { "id": "5296", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 587, 593 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d113.s5.e0" } ] }, { "id": "5297", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 678, 683 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d113.s6.e0" } ] }, { "id": "5298", "type": "Non-Specific_miRNAs", "text": [ "MicroRNAs" ], "offsets": [ [ 696, 705 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d113.s7.e0" } ] }, { "id": "5299", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 707, 713 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d113.s7.e1" } ] }, { "id": "5300", "type": "Relation_Trigger", "text": [ "regulatory" ], "offsets": [ [ 725, 735 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d113.s7.e2" } ] }, { "id": "5301", "type": "Non-Specific_miRNAs", "text": [ "microRNAs" ], "offsets": [ [ 872, 881 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d113.s8.e0" } ] } ]

[]

[]

[]

[ { "id": "5303", "type": "title", "text": [ "Brain cells maintain distinct populations of miRNAs that support physiologically normal patterns of expression, however, certain miRNA abundances are significantly altered in neurodegenerative disorders such as Alzheimer's disease (AD). " ], "offsets": [ [ 0, 237 ] ] }, { "id": "5304", "type": "abstract", "text": [ "Here we provide evidence in human neural (HN) cells of an aluminum-sulfate- and reactive oxygen species (ROS)-mediated up-regulation of an NF-kappaB-sensitive miRNA-146a that down-regulates the expression of complement factor H (CFH), an important repressor of inflammation. " ], "offsets": [ [ 238, 513 ] ] }, { "id": "5305", "type": "abstract", "text": [ "Characterization of an NF-kappaB-regulated, miRNA-146a-mediated down-regulation of complement factor H (CFH) in metal-sulfate-stressed human brain cells. " ], "offsets": [ [ 514, 669 ] ] }, { "id": "5306", "type": "abstract", "text": [ "Micro RNAs (miRNAs) represent a family of small ribonucleic acids (RNAs) that are post-transcriptional regulators of messenger RNA (mRNA) complexity. " ], "offsets": [ [ 670, 820 ] ] }, { "id": "5307", "type": "abstract", "text": [ "An NF-kappaB-containing miRNA-146a-promoter-luciferase reporter construct transfected into HN cells showed significant up-regulation of miRNA-146a after aluminum-sulfate treatment that corresponded to decreased CFH gene expression. " ], "offsets": [ [ 821, 1053 ] ] }, { "id": "5308", "type": "abstract", "text": [ "These data suggest that (1) as in AD brain, NF-kappaB-sensitive, miRNA-146a-mediated, modulation of CFH gene expression may contribute to inflammatory responses in aluminum-stressed HN cells, and (2) underscores the potential of nanomolar aluminum to drive genotoxic mechanisms characteristic of neurodegenerative disease processes. " ], "offsets": [ [ 1054, 1389 ] ] }, { "id": "5309", "type": "abstract", "text": [ "This NF-kappaB-miRNA-146a-CFH signaling circuit is known to be similarly affected by Abeta42 peptides and in AD brain. " ], "offsets": [ [ 1390, 1509 ] ] } ]

[ { "id": "5310", "type": "Diseases", "text": [ "Alzheimer's disease" ], "offsets": [ [ 211, 230 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d114.s0.e0" } ] }, { "id": "5311", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 232, 234 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d114.s0.e1" } ] }, { "id": "5312", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 45, 51 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d114.s0.e2" } ] }, { "id": "5313", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 129, 134 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d114.s0.e3" } ] }, { "id": "5314", "type": "Relation_Trigger", "text": [ "significantly altered" ], "offsets": [ [ 150, 171 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d114.s0.e4" } ] }, { "id": "5315", "type": "Diseases", "text": [ "neurodegenerative disorders" ], "offsets": [ [ 175, 202 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d114.s0.e5" } ] }, { "id": "5316", "type": "Specific_miRNAs", "text": [ "miRNA-146a" ], "offsets": [ [ 397, 407 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d114.s1.e0" } ] }, { "id": "5317", "type": "Genes/Proteins", "text": [ "complement factor H" ], "offsets": [ [ 446, 465 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d114.s1.e1" } ] }, { "id": "5318", "type": "Genes/Proteins", "text": [ "CFH" ], "offsets": [ [ 467, 470 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d114.s1.e2" } ] }, { "id": "5319", "type": "Relation_Trigger", "text": [ "up-regulation" ], "offsets": [ [ 357, 370 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d114.s1.e3" } ] }, { "id": "5320", "type": "Relation_Trigger", "text": [ "repressor" ], "offsets": [ [ 486, 495 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d114.s1.e4" } ] }, { "id": "5321", "type": "Relation_Trigger", "text": [ "down-regulates the expression" ], "offsets": [ [ 413, 442 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d114.s1.e5" } ] }, { "id": "5322", "type": "Species", "text": [ "human" ], "offsets": [ [ 266, 271 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d114.s1.e6" } ] }, { "id": "5323", "type": "Genes/Proteins", "text": [ "complement factor H" ], "offsets": [ [ 597, 616 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d114.s2.e0" } ] }, { "id": "5324", "type": "Genes/Proteins", "text": [ "CFH" ], "offsets": [ [ 618, 621 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d114.s2.e1" } ] }, { "id": "5325", "type": "Specific_miRNAs", "text": [ "miRNA-146a" ], "offsets": [ [ 558, 568 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d114.s2.e2" } ] }, { "id": "5326", "type": "Relation_Trigger", "text": [ "down-regulation" ], "offsets": [ [ 578, 593 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d114.s2.e3" } ] }, { "id": "5327", "type": "Species", "text": [ "human" ], "offsets": [ [ 649, 654 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d114.s2.e4" } ] }, { "id": "5328", "type": "Non-Specific_miRNAs", "text": [ "Micro RNAs" ], "offsets": [ [ 670, 680 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d114.s3.e0" } ] }, { "id": "5329", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 682, 688 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d114.s3.e1" } ] }, { "id": "5330", "type": "Relation_Trigger", "text": [ "regulators" ], "offsets": [ [ 773, 783 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d114.s3.e2" } ] }, { "id": "5331", "type": "Specific_miRNAs", "text": [ "miRNA-146a" ], "offsets": [ [ 957, 967 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d114.s4.e0" } ] }, { "id": "5332", "type": "Genes/Proteins", "text": [ "CFH" ], "offsets": [ [ 1032, 1035 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d114.s4.e1" } ] }, { "id": "5333", "type": "Specific_miRNAs", "text": [ "miRNA-146a" ], "offsets": [ [ 845, 855 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d114.s4.e2" } ] }, { "id": "5334", "type": "Relation_Trigger", "text": [ "up-regulation" ], "offsets": [ [ 940, 953 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d114.s4.e3" } ] }, { "id": "5335", "type": "Relation_Trigger", "text": [ "decreased CFH gene expression" ], "offsets": [ [ 1022, 1051 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d114.s4.e4" } ] }, { "id": "5336", "type": "Genes/Proteins", "text": [ "CFH" ], "offsets": [ [ 1154, 1157 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d114.s5.e0" } ] }, { "id": "5337", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 1088, 1090 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d114.s5.e1" } ] }, { "id": "5338", "type": "Specific_miRNAs", "text": [ "miRNA-146a" ], "offsets": [ [ 1119, 1129 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d114.s5.e2" } ] }, { "id": "5339", "type": "Relation_Trigger", "text": [ "modulation of CFH gene expression" ], "offsets": [ [ 1140, 1173 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d114.s5.e3" } ] }, { "id": "5340", "type": "Diseases", "text": [ "neurodegenerative disease" ], "offsets": [ [ 1350, 1375 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d114.s5.e4" } ] }, { "id": "5341", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 1499, 1501 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d114.s6.e0" } ] }, { "id": "5342", "type": "Genes/Proteins", "text": [ "Abeta42" ], "offsets": [ [ 1475, 1482 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d114.s6.e1" } ] }, { "id": "5343", "type": "Genes/Proteins", "text": [ "CFH" ], "offsets": [ [ 1416, 1419 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d114.s6.e2" } ] }, { "id": "5344", "type": "Specific_miRNAs", "text": [ "miRNA-146a" ], "offsets": [ [ 1405, 1415 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d114.s6.e3" } ] } ]

[]

[]

[ { "id": "5345", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d114.s0.e2", "arg2_id": "miRNA-corp.d114.s0.e0", "normalized": [] }, { "id": "5346", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d114.s0.e2", "arg2_id": "miRNA-corp.d114.s0.e1", "normalized": [] }, { "id": "5347", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d114.s0.e2", "arg2_id": "miRNA-corp.d114.s0.e5", "normalized": [] }, { "id": "5348", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d114.s0.e3", "arg2_id": "miRNA-corp.d114.s0.e0", "normalized": [] }, { "id": "5349", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d114.s0.e3", "arg2_id": "miRNA-corp.d114.s0.e1", "normalized": [] }, { "id": "5350", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d114.s0.e3", "arg2_id": "miRNA-corp.d114.s0.e5", "normalized": [] }, { "id": "5351", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d114.s1.e0", "arg2_id": "miRNA-corp.d114.s1.e1", "normalized": [] }, { "id": "5352", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d114.s1.e0", "arg2_id": "miRNA-corp.d114.s1.e2", "normalized": [] }, { "id": "5353", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d114.s2.e2", "arg2_id": "miRNA-corp.d114.s2.e0", "normalized": [] }, { "id": "5354", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d114.s2.e2", "arg2_id": "miRNA-corp.d114.s2.e1", "normalized": [] }, { "id": "5355", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d114.s4.e2", "arg2_id": "miRNA-corp.d114.s4.e1", "normalized": [] }, { "id": "5356", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d114.s4.e0", "arg2_id": "miRNA-corp.d114.s4.e1", "normalized": [] }, { "id": "5357", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d114.s5.e2", "arg2_id": "miRNA-corp.d114.s5.e4", "normalized": [] }, { "id": "5358", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d114.s5.e2", "arg2_id": "miRNA-corp.d114.s5.e0", "normalized": [] }, { "id": "5359", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d114.s5.e2", "arg2_id": "miRNA-corp.d114.s5.e1", "normalized": [] }, { "id": "5360", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d114.s6.e3", "arg2_id": "miRNA-corp.d114.s6.e1", "normalized": [] }, { "id": "5361", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d114.s6.e3", "arg2_id": "miRNA-corp.d114.s6.e2", "normalized": [] }, { "id": "5362", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d114.s6.e3", "arg2_id": "miRNA-corp.d114.s6.e0", "normalized": [] } ]

[ { "id": "5364", "type": "title", "text": [ "Extensive modulation of a set of microRNAs in primary glioblastoma. " ], "offsets": [ [ 0, 69 ] ] }, { "id": "5365", "type": "abstract", "text": [ "MicroRNAs (miRNAs) are short non-coding RNA molecules playing regulatory roles in animals and plants by repressing translation or cleaving RNA transcripts. " ], "offsets": [ [ 70, 226 ] ] }, { "id": "5366", "type": "abstract", "text": [ "The specific modulation of several microRNAs has been recently associated to some forms of human cancer, suggesting that these short molecules may represent a new class of genes involved in oncogenesis. " ], "offsets": [ [ 227, 430 ] ] }, { "id": "5367", "type": "abstract", "text": [ "In our study, we examined by microarray the global expression levels of 245 microRNAs in glioblastoma multiforme, the most frequent and malignant of primary brain tumors. " ], "offsets": [ [ 431, 602 ] ] }, { "id": "5368", "type": "abstract", "text": [ "The analysis of both glioblastoma tissues and glioblastoma cell lines allowed us to identify a group of microRNAs whose expression is significantly altered in this tumor. " ], "offsets": [ [ 603, 774 ] ] }, { "id": "5369", "type": "abstract", "text": [ "The most interesting results came from miR-221, strongly up-regulated in glioblastoma and from a set of brain-enriched miRNAs, miR-128, miR-181a, miR-181b, and miR-181c, which are down-regulated in glioblastoma. " ], "offsets": [ [ 775, 989 ] ] } ]

[ { "id": "5370", "type": "Relation_Trigger", "text": [ "modulation" ], "offsets": [ [ 10, 20 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d115.s0.e0" } ] }, { "id": "5371", "type": "Non-Specific_miRNAs", "text": [ "microRNAs" ], "offsets": [ [ 33, 42 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d115.s0.e1" } ] }, { "id": "5372", "type": "Diseases", "text": [ "primary glioblastoma" ], "offsets": [ [ 46, 66 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d115.s0.e2" } ] }, { "id": "5373", "type": "Non-Specific_miRNAs", "text": [ "MicroRNAs" ], "offsets": [ [ 70, 79 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d115.s1.e0" } ] }, { "id": "5374", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 81, 87 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d115.s1.e1" } ] }, { "id": "5375", "type": "Relation_Trigger", "text": [ "repressing translation" ], "offsets": [ [ 174, 196 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d115.s1.e2" } ] }, { "id": "5376", "type": "Relation_Trigger", "text": [ "regulatory" ], "offsets": [ [ 132, 142 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d115.s1.e3" } ] }, { "id": "5377", "type": "Non-Specific_miRNAs", "text": [ "microRNAs" ], "offsets": [ [ 262, 271 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d115.s2.e0" } ] }, { "id": "5378", "type": "Relation_Trigger", "text": [ "modulation" ], "offsets": [ [ 240, 250 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d115.s2.e1" } ] }, { "id": "5379", "type": "Relation_Trigger", "text": [ "associated" ], "offsets": [ [ 290, 300 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d115.s2.e2" } ] }, { "id": "5380", "type": "Diseases", "text": [ "cancer" ], "offsets": [ [ 324, 330 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d115.s2.e3" } ] }, { "id": "5381", "type": "Species", "text": [ "human" ], "offsets": [ [ 318, 323 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d115.s2.e4" } ] }, { "id": "5382", "type": "Diseases", "text": [ "glioblastoma" ], "offsets": [ [ 520, 532 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d115.s3.e0" } ] }, { "id": "5383", "type": "Diseases", "text": [ "brain tumors" ], "offsets": [ [ 588, 600 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d115.s3.e1" } ] }, { "id": "5384", "type": "Non-Specific_miRNAs", "text": [ "microRNAs" ], "offsets": [ [ 507, 516 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d115.s3.e2" } ] }, { "id": "5385", "type": "Diseases", "text": [ "glioblastoma" ], "offsets": [ [ 624, 636 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d115.s4.e0" } ] }, { "id": "5386", "type": "Non-Specific_miRNAs", "text": [ "microRNAs" ], "offsets": [ [ 707, 716 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d115.s4.e1" } ] }, { "id": "5387", "type": "Relation_Trigger", "text": [ "expression is significantly altered" ], "offsets": [ [ 723, 758 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d115.s4.e2" } ] }, { "id": "5388", "type": "Diseases", "text": [ "glioblastoma" ], "offsets": [ [ 649, 661 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d115.s4.e3" } ] }, { "id": "5389", "type": "Diseases", "text": [ "tumor" ], "offsets": [ [ 767, 772 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d115.s4.e4" } ] }, { "id": "5390", "type": "Specific_miRNAs", "text": [ "miR-221" ], "offsets": [ [ 814, 821 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d115.s5.e0" } ] }, { "id": "5391", "type": "Specific_miRNAs", "text": [ "miR-128" ], "offsets": [ [ 902, 909 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d115.s5.e1" } ] }, { "id": "5392", "type": "Specific_miRNAs", "text": [ "miR-181a" ], "offsets": [ [ 911, 919 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d115.s5.e2" } ] }, { "id": "5393", "type": "Specific_miRNAs", "text": [ "miR-181b" ], "offsets": [ [ 921, 929 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d115.s5.e3" } ] }, { "id": "5394", "type": "Specific_miRNAs", "text": [ "miR-181c" ], "offsets": [ [ 935, 943 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d115.s5.e4" } ] }, { "id": "5395", "type": "Diseases", "text": [ "glioblastoma" ], "offsets": [ [ 848, 860 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d115.s5.e5" } ] }, { "id": "5396", "type": "Diseases", "text": [ "glioblastoma" ], "offsets": [ [ 973, 985 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d115.s5.e6" } ] }, { "id": "5397", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 894, 900 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d115.s5.e7" } ] }, { "id": "5398", "type": "Relation_Trigger", "text": [ "down-regulated" ], "offsets": [ [ 955, 969 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d115.s5.e8" } ] }, { "id": "5399", "type": "Relation_Trigger", "text": [ "up-regulated" ], "offsets": [ [ 832, 844 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d115.s5.e9" } ] } ]

[]

[]

[ { "id": "5400", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d115.s0.e1", "arg2_id": "miRNA-corp.d115.s0.e2", "normalized": [] }, { "id": "5401", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d115.s2.e0", "arg2_id": "miRNA-corp.d115.s2.e3", "normalized": [] }, { "id": "5402", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d115.s3.e2", "arg2_id": "miRNA-corp.d115.s3.e0", "normalized": [] }, { "id": "5403", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d115.s3.e2", "arg2_id": "miRNA-corp.d115.s3.e1", "normalized": [] }, { "id": "5404", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d115.s4.e1", "arg2_id": "miRNA-corp.d115.s4.e3", "normalized": [] }, { "id": "5405", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d115.s4.e1", "arg2_id": "miRNA-corp.d115.s4.e4", "normalized": [] }, { "id": "5406", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d115.s4.e1", "arg2_id": "miRNA-corp.d115.s4.e0", "normalized": [] }, { "id": "5407", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d115.s5.e0", "arg2_id": "miRNA-corp.d115.s5.e5", "normalized": [] }, { "id": "5408", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d115.s5.e0", "arg2_id": "miRNA-corp.d115.s5.e6", "normalized": [] }, { "id": "5409", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d115.s5.e1", "arg2_id": "miRNA-corp.d115.s5.e5", "normalized": [] }, { "id": "5410", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d115.s5.e1", "arg2_id": "miRNA-corp.d115.s5.e6", "normalized": [] }, { "id": "5411", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d115.s5.e7", "arg2_id": "miRNA-corp.d115.s5.e5", "normalized": [] }, { "id": "5412", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d115.s5.e7", "arg2_id": "miRNA-corp.d115.s5.e6", "normalized": [] }, { "id": "5413", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d115.s5.e2", "arg2_id": "miRNA-corp.d115.s5.e5", "normalized": [] }, { "id": "5414", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d115.s5.e2", "arg2_id": "miRNA-corp.d115.s5.e6", "normalized": [] }, { "id": "5415", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d115.s5.e3", "arg2_id": "miRNA-corp.d115.s5.e5", "normalized": [] }, { "id": "5416", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d115.s5.e3", "arg2_id": "miRNA-corp.d115.s5.e6", "normalized": [] }, { "id": "5417", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d115.s5.e4", "arg2_id": "miRNA-corp.d115.s5.e5", "normalized": [] }, { "id": "5418", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d115.s5.e4", "arg2_id": "miRNA-corp.d115.s5.e6", "normalized": [] } ]

[ { "id": "5420", "type": "title", "text": [ "Pharmacologic and genetic inhibition of p53 corroborated the hypothesis that pre-miR-630 (but not pre-miR-181a) blocks the upstream signaling pathways that are ignited by DNA damage and converge on p53 activation. " ], "offsets": [ [ 0, 214 ] ] }, { "id": "5421", "type": "abstract", "text": [ "Pre-miR-630 arrested A549 cells in the G0-G1 phase of the cell cycle, correlating with increased levels of the cell cycle inhibitor p27(Kip1) as well as with reduced proliferation rates and resulting in greatly diminished sensitivity of A549 cells to the late S-G2-M cell cycle arrest mediated by CDDP. " ], "offsets": [ [ 215, 518 ] ] }, { "id": "5422", "type": "abstract", "text": [ "Altogether, these results identify miR-181a and miR-630 as novel modulators of the CDDP response in NSCLC. " ], "offsets": [ [ 519, 628 ] ] }, { "id": "5423", "type": "abstract", "text": [ "The corresponding synthetic miRNA precursors (pre-miRNAs) per se were not lethal when transfected into A549 cells yet affected cell death induction by CDDP, C2-ceramide, cadmium, etoposide, and mitoxantrone in an inducer-specific fashion. " ], "offsets": [ [ 629, 868 ] ] }, { "id": "5424", "type": "abstract", "text": [ "Whereas synthetic miRNA inhibitors (anti-miRNAs) targeting miR-181a and miR-630 failed to modulate the response of A549 to CDDP, pre-miR-181a and pre-miR-630 enhanced and reduced CDDP-triggered cell death, respectively. " ], "offsets": [ [ 869, 1089 ] ] }, { "id": "5425", "type": "abstract", "text": [ "Pre-miR-181a and pre-miR-630 consistently modulated mitochondrial/postmitochondrial steps of the intrinsic pathway of apoptosis, including Bax oligomerization, mitochondrial transmembrane potential dissipation, and the proteolytic maturation of caspase-9 and caspase-3. " ], "offsets": [ [ 1090, 1360 ] ] }, { "id": "5426", "type": "abstract", "text": [ "In addition, pre-miR-630 blocked early manifestations of the DNA damage response, including the phosphorylation of the ataxia-telangiectasia mutated (ATM) kinase and of two ATM substrates, histone H2AX and p53. " ], "offsets": [ [ 1361, 1572 ] ] }, { "id": "5427", "type": "abstract", "text": [ "miR-181a and miR-630 regulate cisplatin-induced cancer cell death. " ], "offsets": [ [ 1573, 1641 ] ] }, { "id": "5428", "type": "abstract", "text": [ "MicroRNAs (miRNA) are noncoding RNAs that regulate multiple cellular processes, including proliferation and apoptosis. " ], "offsets": [ [ 1642, 1761 ] ] }, { "id": "5429", "type": "abstract", "text": [ "We used microarray technology to identify miRNAs that were upregulated by non-small cell lung cancer (NSCLC) A549 cells in response to cisplatin (CDDP). " ], "offsets": [ [ 1762, 1915 ] ] } ]

[ { "id": "5430", "type": "Specific_miRNAs", "text": [ "miR-181a" ], "offsets": [ [ 102, 110 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d116.s0.e0" } ] }, { "id": "5431", "type": "Specific_miRNAs", "text": [ "miR-630" ], "offsets": [ [ 81, 88 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d116.s0.e1" } ] }, { "id": "5432", "type": "Genes/Proteins", "text": [ "p53" ], "offsets": [ [ 198, 201 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d116.s0.e2" } ] }, { "id": "5433", "type": "Genes/Proteins", "text": [ "p53" ], "offsets": [ [ 40, 43 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d116.s0.e3" } ] }, { "id": "5434", "type": "Relation_Trigger", "text": [ "inhibition" ], "offsets": [ [ 26, 36 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d116.s0.e4" } ] }, { "id": "5435", "type": "Relation_Trigger", "text": [ "activation" ], "offsets": [ [ 202, 212 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d116.s0.e5" } ] }, { "id": "5436", "type": "Relation_Trigger", "text": [ "blocks" ], "offsets": [ [ 112, 118 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d116.s0.e6" } ] }, { "id": "5437", "type": "Diseases", "text": [ "DNA damage" ], "offsets": [ [ 171, 181 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d116.s0.e7" } ] }, { "id": "5438", "type": "Specific_miRNAs", "text": [ "miR-630" ], "offsets": [ [ 219, 226 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d116.s1.e0" } ] }, { "id": "5439", "type": "Genes/Proteins", "text": [ "p27" ], "offsets": [ [ 347, 350 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d116.s1.e1" } ] }, { "id": "5440", "type": "Genes/Proteins", "text": [ "Kip1" ], "offsets": [ [ 351, 355 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d116.s1.e2" } ] }, { "id": "5441", "type": "Relation_Trigger", "text": [ "correlating" ], "offsets": [ [ 285, 296 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d116.s1.e3" } ] }, { "id": "5442", "type": "Relation_Trigger", "text": [ "inhibitor" ], "offsets": [ [ 337, 346 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d116.s1.e4" } ] }, { "id": "5443", "type": "Relation_Trigger", "text": [ "increased levels" ], "offsets": [ [ 302, 318 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d116.s1.e5" } ] }, { "id": "5444", "type": "Specific_miRNAs", "text": [ "miR-181a" ], "offsets": [ [ 554, 562 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d116.s2.e0" } ] }, { "id": "5445", "type": "Specific_miRNAs", "text": [ "miR-630" ], "offsets": [ [ 567, 574 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d116.s2.e1" } ] }, { "id": "5446", "type": "Diseases", "text": [ "NSCLC" ], "offsets": [ [ 619, 624 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d116.s2.e2" } ] }, { "id": "5447", "type": "Relation_Trigger", "text": [ "modulators" ], "offsets": [ [ 584, 594 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d116.s2.e3" } ] }, { "id": "5448", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 657, 662 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d116.s3.e0" } ] }, { "id": "5449", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 679, 685 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d116.s3.e1" } ] }, { "id": "5450", "type": "Specific_miRNAs", "text": [ "miR-181a" ], "offsets": [ [ 1002, 1010 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d116.s4.e0" } ] }, { "id": "5451", "type": "Specific_miRNAs", "text": [ "miR-630" ], "offsets": [ [ 1019, 1026 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d116.s4.e1" } ] }, { "id": "5452", "type": "Specific_miRNAs", "text": [ "miR-181a" ], "offsets": [ [ 928, 936 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d116.s4.e2" } ] }, { "id": "5453", "type": "Specific_miRNAs", "text": [ "miR-630" ], "offsets": [ [ 941, 948 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d116.s4.e3" } ] }, { "id": "5454", "type": "Relation_Trigger", "text": [ "inhibitors" ], "offsets": [ [ 893, 903 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d116.s4.e4" } ] }, { "id": "5455", "type": "Relation_Trigger", "text": [ "targeting" ], "offsets": [ [ 918, 927 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d116.s4.e5" } ] }, { "id": "5456", "type": "Relation_Trigger", "text": [ "modulate" ], "offsets": [ [ 959, 967 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d116.s4.e6" } ] }, { "id": "5457", "type": "Specific_miRNAs", "text": [ "miR-181a" ], "offsets": [ [ 1094, 1102 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d116.s5.e0" } ] }, { "id": "5458", "type": "Specific_miRNAs", "text": [ "miR-630" ], "offsets": [ [ 1111, 1118 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d116.s5.e1" } ] }, { "id": "5459", "type": "Genes/Proteins", "text": [ "caspase-9" ], "offsets": [ [ 1335, 1344 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d116.s5.e2" } ] }, { "id": "5460", "type": "Genes/Proteins", "text": [ "caspase-3" ], "offsets": [ [ 1349, 1358 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d116.s5.e3" } ] }, { "id": "5461", "type": "Genes/Proteins", "text": [ "Bax" ], "offsets": [ [ 1229, 1232 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d116.s5.e4" } ] }, { "id": "5462", "type": "Relation_Trigger", "text": [ "modulated" ], "offsets": [ [ 1132, 1141 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d116.s5.e5" } ] }, { "id": "5463", "type": "Specific_miRNAs", "text": [ "miR-630" ], "offsets": [ [ 1378, 1385 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d116.s6.e0" } ] }, { "id": "5464", "type": "Genes/Proteins", "text": [ "ataxia-telangiectasia mutated" ], "offsets": [ [ 1480, 1509 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d116.s6.e1" } ] }, { "id": "5465", "type": "Genes/Proteins", "text": [ "ATM" ], "offsets": [ [ 1511, 1514 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d116.s6.e2" } ] }, { "id": "5466", "type": "Genes/Proteins", "text": [ "ATM" ], "offsets": [ [ 1534, 1537 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d116.s6.e3" } ] }, { "id": "5467", "type": "Genes/Proteins", "text": [ "H2AX" ], "offsets": [ [ 1558, 1562 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d116.s6.e4" } ] }, { "id": "5468", "type": "Genes/Proteins", "text": [ "p53" ], "offsets": [ [ 1567, 1570 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d116.s6.e5" } ] }, { "id": "5469", "type": "Relation_Trigger", "text": [ "blocked" ], "offsets": [ [ 1386, 1393 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d116.s6.e6" } ] }, { "id": "5470", "type": "Diseases", "text": [ "DNA damage" ], "offsets": [ [ 1422, 1432 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d116.s6.e7" } ] }, { "id": "5471", "type": "Specific_miRNAs", "text": [ "miR-181a" ], "offsets": [ [ 1573, 1581 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d116.s7.e0" } ] }, { "id": "5472", "type": "Specific_miRNAs", "text": [ "miR-630" ], "offsets": [ [ 1586, 1593 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d116.s7.e1" } ] }, { "id": "5473", "type": "Relation_Trigger", "text": [ "regulate" ], "offsets": [ [ 1594, 1602 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d116.s7.e2" } ] }, { "id": "5474", "type": "Diseases", "text": [ "cancer" ], "offsets": [ [ 1621, 1627 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d116.s7.e3" } ] }, { "id": "5475", "type": "Non-Specific_miRNAs", "text": [ "MicroRNAs" ], "offsets": [ [ 1642, 1651 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d116.s8.e0" } ] }, { "id": "5476", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1653, 1658 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d116.s8.e1" } ] }, { "id": "5477", "type": "Relation_Trigger", "text": [ "regulate" ], "offsets": [ [ 1684, 1692 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d116.s8.e2" } ] }, { "id": "5478", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1804, 1810 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d116.s9.e0" } ] }, { "id": "5479", "type": "Diseases", "text": [ "non-small cell lung cancer" ], "offsets": [ [ 1836, 1862 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d116.s9.e1" } ] }, { "id": "5480", "type": "Diseases", "text": [ "NSCLC" ], "offsets": [ [ 1864, 1869 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d116.s9.e2" } ] }, { "id": "5481", "type": "Relation_Trigger", "text": [ "upregulated" ], "offsets": [ [ 1821, 1832 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d116.s9.e3" } ] } ]

[]

[]

[ { "id": "5482", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d116.s0.e1", "arg2_id": "miRNA-corp.d116.s0.e2", "normalized": [] }, { "id": "5483", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d116.s0.e1", "arg2_id": "miRNA-corp.d116.s0.e3", "normalized": [] }, { "id": "5484", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d116.s0.e1", "arg2_id": "miRNA-corp.d116.s0.e7", "normalized": [] }, { "id": "5485", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d116.s0.e0", "arg2_id": "miRNA-corp.d116.s0.e2", "normalized": [] }, { "id": "5486", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d116.s0.e0", "arg2_id": "miRNA-corp.d116.s0.e3", "normalized": [] }, { "id": "5487", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d116.s0.e0", "arg2_id": "miRNA-corp.d116.s0.e7", "normalized": [] }, { "id": "5488", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d116.s1.e0", "arg2_id": "miRNA-corp.d116.s1.e1", "normalized": [] }, { "id": "5489", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d116.s1.e0", "arg2_id": "miRNA-corp.d116.s1.e2", "normalized": [] }, { "id": "5490", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d116.s2.e1", "arg2_id": "miRNA-corp.d116.s2.e2", "normalized": [] }, { "id": "5491", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d116.s2.e0", "arg2_id": "miRNA-corp.d116.s2.e2", "normalized": [] }, { "id": "5492", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d116.s5.e0", "arg2_id": "miRNA-corp.d116.s5.e2", "normalized": [] }, { "id": "5493", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d116.s5.e0", "arg2_id": "miRNA-corp.d116.s5.e3", "normalized": [] }, { "id": "5494", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d116.s5.e0", "arg2_id": "miRNA-corp.d116.s5.e4", "normalized": [] }, { "id": "5495", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d116.s5.e1", "arg2_id": "miRNA-corp.d116.s5.e2", "normalized": [] }, { "id": "5496", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d116.s5.e1", "arg2_id": "miRNA-corp.d116.s5.e3", "normalized": [] }, { "id": "5497", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d116.s5.e1", "arg2_id": "miRNA-corp.d116.s5.e4", "normalized": [] }, { "id": "5498", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d116.s6.e0", "arg2_id": "miRNA-corp.d116.s6.e1", "normalized": [] }, { "id": "5499", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d116.s6.e0", "arg2_id": "miRNA-corp.d116.s6.e2", "normalized": [] }, { "id": "5500", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d116.s6.e0", "arg2_id": "miRNA-corp.d116.s6.e3", "normalized": [] }, { "id": "5501", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d116.s6.e0", "arg2_id": "miRNA-corp.d116.s6.e4", "normalized": [] }, { "id": "5502", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d116.s6.e0", "arg2_id": "miRNA-corp.d116.s6.e5", "normalized": [] }, { "id": "5503", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d116.s6.e0", "arg2_id": "miRNA-corp.d116.s6.e7", "normalized": [] }, { "id": "5504", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d116.s7.e0", "arg2_id": "miRNA-corp.d116.s7.e3", "normalized": [] }, { "id": "5505", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d116.s7.e1", "arg2_id": "miRNA-corp.d116.s7.e3", "normalized": [] }, { "id": "5506", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d116.s9.e0", "arg2_id": "miRNA-corp.d116.s9.e1", "normalized": [] }, { "id": "5507", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d116.s9.e0", "arg2_id": "miRNA-corp.d116.s9.e2", "normalized": [] } ]

[ { "id": "5509", "type": "abstract", "text": [ "Positioning of RNA regulatory mechanisms on endolysosomal membranes might permit rapid and localized control of microRNA (miRNA) gene regulatory programs and mRNA translation in response to environmental signals, such as activated plasma membrane receptors transported on endosomes. " ], "offsets": [ [ 0, 283 ] ] }, { "id": "5510", "type": "abstract", "text": [ "Finally, we suggest that the pathology of several conditions, including Huntington's disease, might be a consequence of the disruption of the control of RNA via endolysosomal membranes. " ], "offsets": [ [ 284, 472 ] ] }, { "id": "5511", "type": "abstract", "text": [ "Recent advances in the cell biology of RNA silencing have unraveled an intriguing association of post-transcriptionally regulated RNA with endolysosomal membranes in several circumstances of mRNA localization, microRNA activity and viral RNA transport and packaging. " ], "offsets": [ [ 473, 740 ] ] } ]

[ { "id": "5512", "type": "Non-Specific_miRNAs", "text": [ "microRNA" ], "offsets": [ [ 112, 120 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d117.s1.e0" } ] }, { "id": "5513", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 122, 127 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d117.s1.e1" } ] }, { "id": "5514", "type": "Relation_Trigger", "text": [ "regulatory" ], "offsets": [ [ 134, 144 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d117.s1.e2" } ] }, { "id": "5515", "type": "Relation_Trigger", "text": [ "activated" ], "offsets": [ [ 221, 230 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d117.s1.e3" } ] }, { "id": "5516", "type": "Relation_Trigger", "text": [ "regulatory" ], "offsets": [ [ 19, 29 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d117.s1.e4" } ] }, { "id": "5517", "type": "Diseases", "text": [ "Huntington's disease" ], "offsets": [ [ 356, 376 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d117.s2.e0" } ] }, { "id": "5518", "type": "Non-Specific_miRNAs", "text": [ "microRNA" ], "offsets": [ [ 683, 691 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d117.s4.e0" } ] }, { "id": "5519", "type": "Relation_Trigger", "text": [ "association" ], "offsets": [ [ 555, 566 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d117.s4.e1" } ] }, { "id": "5520", "type": "Relation_Trigger", "text": [ "regulated" ], "offsets": [ [ 593, 602 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d117.s4.e2" } ] } ]

[]

[]

[]

[ { "id": "5522", "type": "title", "text": [ "A specific subset of five miRNAs revealed by in silico target prediction was significantly overexpressed in NFA samples; three miRs (miR-128a, miR-155, and miR-516a-3p) targeted the 3'-untranslated region of the Wee1 transcript, and exogenous overexpression of these miRs inhibited Wee1 protein expression and HeLa cell proliferation. " ], "offsets": [ [ 0, 335 ] ] }, { "id": "5523", "type": "abstract", "text": [ "RESULTS: Wee1 protein expression was decreased in NFAs and GH-producing tumors with or without prolactin production, but no change in mRNA expression was observed with qRT-PCR. " ], "offsets": [ [ 336, 513 ] ] }, { "id": "5524", "type": "abstract", "text": [ "CONCLUSIONS: To our knowledge, this is the first report suggesting that regulation of Wee1 kinase by miRs may be linked to pituitary tumorigenesis. " ], "offsets": [ [ 514, 664 ] ] }, { "id": "5525", "type": "abstract", "text": [ "CONTEXT: The tumorigenic mechanisms involved in pituitary adenomas, especially of nonfunctional pituitary adenomas (NFAs), remains unclear. " ], "offsets": [ [ 665, 805 ] ] }, { "id": "5526", "type": "abstract", "text": [ "Down-regulation of Wee1 kinase by a specific subset of microRNA in human sporadic pituitary adenomas. " ], "offsets": [ [ 806, 909 ] ] }, { "id": "5527", "type": "abstract", "text": [ "OBJECTIVE: Our objective was to examine the expression of Wee1 in pituitary tumors and to identify microRNAs (miRs) that can regulate its expression. " ], "offsets": [ [ 910, 1060 ] ] }, { "id": "5528", "type": "abstract", "text": [ "Various cell cycle inhibitors have been found to be underexpressed in pituitary tumors; however, Wee1 kinase, a nuclear protein that delays mitosis and was recently recognized as a tumor suppressor gene, has not been previously investigated in pituitary tumors. " ], "offsets": [ [ 1061, 1323 ] ] }, { "id": "5529", "type": "abstract", "text": [ "Identification of miRs targeting the Wee1 3'-untranslated region was performed by miR array followed by expression analysis of identified miRs using qRT-PCR. " ], "offsets": [ [ 1324, 1482 ] ] }, { "id": "5530", "type": "abstract", "text": [ "DESIGN: Expression of Wee1 was examined by immunohistochemistry and quantitative real-time PCR (qRT-PCR). " ], "offsets": [ [ 1483, 1589 ] ] }, { "id": "5531", "type": "abstract", "text": [ "PATIENTS: A total of 57 pituitary tissue samples including 27 NFAs, 15 GH-producing adenomas with or without prolactin overproduction, and 15 normal pituitary glands were analyzed. " ], "offsets": [ [ 1590, 1771 ] ] }, { "id": "5532", "type": "abstract", "text": [ "Dual-luciferase assay and transient transfection of miRs into Hela cells followed by immunoblot analysis of Wee1 protein and cell proliferation analysis were carried out. " ], "offsets": [ [ 1772, 1943 ] ] } ]

[ { "id": "5533", "type": "Specific_miRNAs", "text": [ "miR-155" ], "offsets": [ [ 143, 150 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d118.s0.e0" } ] }, { "id": "5534", "type": "Specific_miRNAs", "text": [ "miR-516a-3p" ], "offsets": [ [ 156, 167 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d118.s0.e1" } ] }, { "id": "5535", "type": "Specific_miRNAs", "text": [ "miR-128a" ], "offsets": [ [ 133, 141 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d118.s0.e2" } ] }, { "id": "5536", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 26, 32 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d118.s0.e3" } ] }, { "id": "5537", "type": "Non-Specific_miRNAs", "text": [ "miRs" ], "offsets": [ [ 127, 131 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d118.s0.e4" } ] }, { "id": "5538", "type": "Non-Specific_miRNAs", "text": [ "miRs" ], "offsets": [ [ 267, 271 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d118.s0.e5" } ] }, { "id": "5539", "type": "Genes/Proteins", "text": [ "Wee1" ], "offsets": [ [ 212, 216 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d118.s0.e6" } ] }, { "id": "5540", "type": "Genes/Proteins", "text": [ "Wee1" ], "offsets": [ [ 282, 286 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d118.s0.e7" } ] }, { "id": "5541", "type": "Relation_Trigger", "text": [ "overexpression" ], "offsets": [ [ 243, 257 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d118.s0.e8" } ] }, { "id": "5542", "type": "Relation_Trigger", "text": [ "target" ], "offsets": [ [ 55, 61 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d118.s0.e9" } ] }, { "id": "5543", "type": "Relation_Trigger", "text": [ "overexpressed" ], "offsets": [ [ 91, 104 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d118.s0.e10" } ] }, { "id": "5544", "type": "Relation_Trigger", "text": [ "inhibited Wee1 protein expression" ], "offsets": [ [ 272, 305 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d118.s0.e11" } ] }, { "id": "5545", "type": "Relation_Trigger", "text": [ "targeted the 3'-untranslated region" ], "offsets": [ [ 169, 204 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d118.s0.e12" } ] }, { "id": "5546", "type": "Genes/Proteins", "text": [ "Wee1" ], "offsets": [ [ 345, 349 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d118.s1.e0" } ] }, { "id": "5547", "type": "Relation_Trigger", "text": [ "change in mRNA expression" ], "offsets": [ [ 460, 485 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d118.s1.e1" } ] }, { "id": "5548", "type": "Relation_Trigger", "text": [ "protein expression was decreased" ], "offsets": [ [ 350, 382 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d118.s1.e2" } ] }, { "id": "5549", "type": "Genes/Proteins", "text": [ "prolactin" ], "offsets": [ [ 431, 440 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d118.s1.e3" } ] }, { "id": "5550", "type": "Diseases", "text": [ "tumors" ], "offsets": [ [ 408, 414 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d118.s1.e4" } ] }, { "id": "5551", "type": "Non-Specific_miRNAs", "text": [ "miRs" ], "offsets": [ [ 615, 619 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d118.s2.e0" } ] }, { "id": "5552", "type": "Relation_Trigger", "text": [ "regulation" ], "offsets": [ [ 586, 596 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d118.s2.e1" } ] }, { "id": "5553", "type": "Genes/Proteins", "text": [ "Wee1" ], "offsets": [ [ 600, 604 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d118.s2.e2" } ] }, { "id": "5554", "type": "Diseases", "text": [ "pituitary adenomas" ], "offsets": [ [ 713, 731 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d118.s3.e0" } ] }, { "id": "5555", "type": "Non-Specific_miRNAs", "text": [ "microRNA" ], "offsets": [ [ 861, 869 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d118.s4.e0" } ] }, { "id": "5556", "type": "Diseases", "text": [ "pituitary adenomas" ], "offsets": [ [ 888, 906 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d118.s4.e1" } ] }, { "id": "5557", "type": "Relation_Trigger", "text": [ "Down-regulation" ], "offsets": [ [ 806, 821 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d118.s4.e2" } ] }, { "id": "5558", "type": "Genes/Proteins", "text": [ "Wee1" ], "offsets": [ [ 825, 829 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d118.s4.e3" } ] }, { "id": "5559", "type": "Species", "text": [ "human" ], "offsets": [ [ 873, 878 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d118.s4.e4" } ] }, { "id": "5560", "type": "Genes/Proteins", "text": [ "Wee1" ], "offsets": [ [ 968, 972 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d118.s5.e0" } ] }, { "id": "5561", "type": "Non-Specific_miRNAs", "text": [ "microRNAs" ], "offsets": [ [ 1009, 1018 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d118.s5.e1" } ] }, { "id": "5562", "type": "Non-Specific_miRNAs", "text": [ "miRs" ], "offsets": [ [ 1020, 1024 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d118.s5.e2" } ] }, { "id": "5563", "type": "Diseases", "text": [ "pituitary tumors" ], "offsets": [ [ 976, 992 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d118.s5.e3" } ] }, { "id": "5564", "type": "Relation_Trigger", "text": [ "regulate its expression" ], "offsets": [ [ 1035, 1058 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d118.s5.e4" } ] }, { "id": "5565", "type": "Diseases", "text": [ "pituitary tumors" ], "offsets": [ [ 1131, 1147 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d118.s6.e0" } ] }, { "id": "5566", "type": "Diseases", "text": [ "pituitary tumors" ], "offsets": [ [ 1305, 1321 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d118.s6.e1" } ] }, { "id": "5567", "type": "Relation_Trigger", "text": [ "underexpressed" ], "offsets": [ [ 1113, 1127 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d118.s6.e2" } ] }, { "id": "5568", "type": "Relation_Trigger", "text": [ "inhibitors" ], "offsets": [ [ 1080, 1090 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d118.s6.e3" } ] }, { "id": "5569", "type": "Relation_Trigger", "text": [ "tumor suppressor" ], "offsets": [ [ 1242, 1258 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d118.s6.e4" } ] }, { "id": "5570", "type": "Genes/Proteins", "text": [ "Wee1" ], "offsets": [ [ 1158, 1162 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d118.s6.e5" } ] }, { "id": "5571", "type": "Non-Specific_miRNAs", "text": [ "miRs" ], "offsets": [ [ 1342, 1346 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d118.s7.e0" } ] }, { "id": "5572", "type": "Non-Specific_miRNAs", "text": [ "miR" ], "offsets": [ [ 1406, 1409 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d118.s7.e1" } ] }, { "id": "5573", "type": "Non-Specific_miRNAs", "text": [ "miRs" ], "offsets": [ [ 1462, 1466 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d118.s7.e2" } ] }, { "id": "5574", "type": "Genes/Proteins", "text": [ "Wee1" ], "offsets": [ [ 1361, 1365 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d118.s7.e3" } ] }, { "id": "5575", "type": "Relation_Trigger", "text": [ "targeting the Wee1 3'-untranslated region" ], "offsets": [ [ 1347, 1388 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d118.s7.e4" } ] }, { "id": "5576", "type": "Genes/Proteins", "text": [ "Wee1" ], "offsets": [ [ 1505, 1509 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d118.s8.e0" } ] }, { "id": "5577", "type": "Diseases", "text": [ "adenomas" ], "offsets": [ [ 1674, 1682 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d118.s9.e0" } ] }, { "id": "5578", "type": "Genes/Proteins", "text": [ "prolactin" ], "offsets": [ [ 1699, 1708 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d118.s9.e1" } ] }, { "id": "5579", "type": "Species", "text": [ "PATIENTS" ], "offsets": [ [ 1590, 1598 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d118.s9.e2" } ] }, { "id": "5580", "type": "Non-Specific_miRNAs", "text": [ "miRs" ], "offsets": [ [ 1824, 1828 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d118.s10.e0" } ] }, { "id": "5581", "type": "Genes/Proteins", "text": [ "Wee1" ], "offsets": [ [ 1880, 1884 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d118.s10.e1" } ] } ]

[]

[]

[ { "id": "5582", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d118.s0.e0", "arg2_id": "miRNA-corp.d118.s0.e6", "normalized": [] }, { "id": "5583", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d118.s0.e0", "arg2_id": "miRNA-corp.d118.s0.e7", "normalized": [] }, { "id": "5584", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d118.s0.e3", "arg2_id": "miRNA-corp.d118.s0.e6", "normalized": [] }, { "id": "5585", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d118.s0.e3", "arg2_id": "miRNA-corp.d118.s0.e7", "normalized": [] }, { "id": "5586", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d118.s0.e4", "arg2_id": "miRNA-corp.d118.s0.e6", "normalized": [] }, { "id": "5587", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d118.s0.e4", "arg2_id": "miRNA-corp.d118.s0.e7", "normalized": [] }, { "id": "5588", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d118.s0.e5", "arg2_id": "miRNA-corp.d118.s0.e6", "normalized": [] }, { "id": "5589", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d118.s0.e5", "arg2_id": "miRNA-corp.d118.s0.e7", "normalized": [] }, { "id": "5590", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d118.s0.e1", "arg2_id": "miRNA-corp.d118.s0.e6", "normalized": [] }, { "id": "5591", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d118.s0.e1", "arg2_id": "miRNA-corp.d118.s0.e7", "normalized": [] }, { "id": "5592", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d118.s0.e2", "arg2_id": "miRNA-corp.d118.s0.e6", "normalized": [] }, { "id": "5593", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d118.s0.e2", "arg2_id": "miRNA-corp.d118.s0.e7", "normalized": [] }, { "id": "5594", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d118.s2.e0", "arg2_id": "miRNA-corp.d118.s2.e2", "normalized": [] }, { "id": "5595", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d118.s4.e0", "arg2_id": "miRNA-corp.d118.s4.e1", "normalized": [] }, { "id": "5596", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d118.s4.e0", "arg2_id": "miRNA-corp.d118.s4.e3", "normalized": [] }, { "id": "5597", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d118.s5.e1", "arg2_id": "miRNA-corp.d118.s5.e0", "normalized": [] }, { "id": "5598", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d118.s5.e1", "arg2_id": "miRNA-corp.d118.s5.e3", "normalized": [] }, { "id": "5599", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d118.s5.e2", "arg2_id": "miRNA-corp.d118.s5.e0", "normalized": [] }, { "id": "5600", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d118.s5.e2", "arg2_id": "miRNA-corp.d118.s5.e3", "normalized": [] }, { "id": "5601", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d118.s7.e2", "arg2_id": "miRNA-corp.d118.s7.e3", "normalized": [] }, { "id": "5602", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d118.s7.e0", "arg2_id": "miRNA-corp.d118.s7.e3", "normalized": [] }, { "id": "5603", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d118.s7.e1", "arg2_id": "miRNA-corp.d118.s7.e3", "normalized": [] }, { "id": "5604", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d118.s10.e0", "arg2_id": "miRNA-corp.d118.s10.e1", "normalized": [] } ]

[ { "id": "5606", "type": "title", "text": [ "Although microRNAs are being extensively studied for their involvement in cancer and development, little is known about their roles in Alzheimer's disease (AD). " ], "offsets": [ [ 0, 161 ] ] }, { "id": "5607", "type": "abstract", "text": [ "Joint genome-wide profiling of miRNA and mRNA expression in Alzheimer's disease cortex reveals altered miRNA regulation. " ], "offsets": [ [ 162, 284 ] ] }, { "id": "5608", "type": "abstract", "text": [ "These data provided the unique opportunity to study the relationship between miRNA and mRNA expression in normal and AD brains. " ], "offsets": [ [ 285, 413 ] ] }, { "id": "5609", "type": "abstract", "text": [ "In this study, we used microarrays for the first joint profiling and analysis of miRNAs and mRNAs expression in brain cortex from AD and age-matched control subjects. " ], "offsets": [ [ 414, 581 ] ] }, { "id": "5610", "type": "abstract", "text": [ "Comparative analysis with independent cancer datasets showed that such miRNA-mRNA expression correlations are not static, but rather context-dependent. " ], "offsets": [ [ 582, 734 ] ] }, { "id": "5611", "type": "abstract", "text": [ "Using a non-parametric analysis, we showed that the levels of many miRNAs can be either positively or negatively correlated with those of their target mRNAs. " ], "offsets": [ [ 735, 893 ] ] }, { "id": "5612", "type": "abstract", "text": [ "Our results demonstrate a robust relationship between the levels of miRNAs and those of their targets in the brain. " ], "offsets": [ [ 894, 1010 ] ] }, { "id": "5613", "type": "abstract", "text": [ "Subsequently, we identified a large set of miRNA-mRNA associations that are changed in AD versus control, highlighting AD-specific changes in the miRNA regulatory system. " ], "offsets": [ [ 1011, 1182 ] ] }, { "id": "5614", "type": "abstract", "text": [ "This has implications in the study of the molecular pathology of AD, as well as miRNA biology in general. " ], "offsets": [ [ 1183, 1291 ] ] } ]

[ { "id": "5615", "type": "Non-Specific_miRNAs", "text": [ "microRNAs" ], "offsets": [ [ 9, 18 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d119.s0.e0" } ] }, { "id": "5616", "type": "Diseases", "text": [ "Alzheimer's disease" ], "offsets": [ [ 135, 154 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d119.s0.e1" } ] }, { "id": "5617", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 156, 158 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d119.s0.e2" } ] }, { "id": "5618", "type": "Diseases", "text": [ "cancer" ], "offsets": [ [ 74, 80 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d119.s0.e3" } ] }, { "id": "5619", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 193, 198 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d119.s1.e0" } ] }, { "id": "5620", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 265, 270 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d119.s1.e1" } ] }, { "id": "5621", "type": "Diseases", "text": [ "Alzheimer's disease" ], "offsets": [ [ 222, 241 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d119.s1.e2" } ] }, { "id": "5622", "type": "Relation_Trigger", "text": [ "altered miRNA regulation" ], "offsets": [ [ 257, 281 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d119.s1.e3" } ] }, { "id": "5623", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 362, 367 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d119.s2.e0" } ] }, { "id": "5624", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 402, 404 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d119.s2.e1" } ] }, { "id": "5625", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 495, 501 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d119.s3.e0" } ] }, { "id": "5626", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 544, 546 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d119.s3.e1" } ] }, { "id": "5627", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 653, 658 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d119.s4.e0" } ] }, { "id": "5628", "type": "Relation_Trigger", "text": [ "expression correlations" ], "offsets": [ [ 664, 687 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d119.s4.e1" } ] }, { "id": "5629", "type": "Diseases", "text": [ "cancer" ], "offsets": [ [ 620, 626 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d119.s4.e2" } ] }, { "id": "5630", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 802, 808 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d119.s5.e0" } ] }, { "id": "5631", "type": "Relation_Trigger", "text": [ "target" ], "offsets": [ [ 879, 885 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d119.s5.e1" } ] }, { "id": "5632", "type": "Relation_Trigger", "text": [ "levels of many miRNAs can be either positively" ], "offsets": [ [ 787, 833 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d119.s5.e2" } ] }, { "id": "5633", "type": "Relation_Trigger", "text": [ "negatively correlated" ], "offsets": [ [ 837, 858 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d119.s5.e3" } ] }, { "id": "5634", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 962, 968 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d119.s6.e0" } ] }, { "id": "5635", "type": "Relation_Trigger", "text": [ "targets" ], "offsets": [ [ 988, 995 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d119.s6.e1" } ] }, { "id": "5636", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1157, 1162 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d119.s7.e0" } ] }, { "id": "5637", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 1098, 1100 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d119.s7.e1" } ] }, { "id": "5638", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1054, 1059 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d119.s7.e2" } ] }, { "id": "5639", "type": "Relation_Trigger", "text": [ "associations" ], "offsets": [ [ 1065, 1077 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d119.s7.e3" } ] }, { "id": "5640", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 1130, 1132 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d119.s7.e4" } ] }, { "id": "5641", "type": "Relation_Trigger", "text": [ "regulatory" ], "offsets": [ [ 1163, 1173 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d119.s7.e5" } ] }, { "id": "5642", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1263, 1268 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d119.s8.e0" } ] }, { "id": "5643", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 1248, 1250 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d119.s8.e1" } ] } ]

[]

[]

[ { "id": "5644", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d119.s0.e0", "arg2_id": "miRNA-corp.d119.s0.e1", "normalized": [] }, { "id": "5645", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d119.s0.e0", "arg2_id": "miRNA-corp.d119.s0.e2", "normalized": [] }, { "id": "5646", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d119.s0.e0", "arg2_id": "miRNA-corp.d119.s0.e3", "normalized": [] }, { "id": "5647", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d119.s1.e0", "arg2_id": "miRNA-corp.d119.s1.e2", "normalized": [] }, { "id": "5648", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d119.s1.e1", "arg2_id": "miRNA-corp.d119.s1.e2", "normalized": [] }, { "id": "5649", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d119.s2.e0", "arg2_id": "miRNA-corp.d119.s2.e1", "normalized": [] }, { "id": "5650", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d119.s3.e0", "arg2_id": "miRNA-corp.d119.s3.e1", "normalized": [] }, { "id": "5651", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d119.s4.e0", "arg2_id": "miRNA-corp.d119.s4.e2", "normalized": [] }, { "id": "5652", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d119.s7.e2", "arg2_id": "miRNA-corp.d119.s7.e1", "normalized": [] }, { "id": "5653", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d119.s7.e2", "arg2_id": "miRNA-corp.d119.s7.e4", "normalized": [] }, { "id": "5654", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d119.s7.e0", "arg2_id": "miRNA-corp.d119.s7.e1", "normalized": [] }, { "id": "5655", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d119.s7.e0", "arg2_id": "miRNA-corp.d119.s7.e4", "normalized": [] }, { "id": "5656", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d119.s8.e0", "arg2_id": "miRNA-corp.d119.s8.e1", "normalized": [] } ]

[ { "id": "5658", "type": "title", "text": [ "In this review article, the molecular mechanisms underlying the role and function of miRNAs in the regulation of genes involved in neurological and neurodegenerative diseases will be discussed, with a focus on the fragile X syndrome, Alzheimer's disease (AD) and prion disease. " ], "offsets": [ [ 0, 280 ] ] }, { "id": "5659", "type": "abstract", "text": [ "Likely to play a central role in health and disease, a dysfunctional miRNA-based regulation of gene expression may represent the main etiologic factor underlying diseases affecting major organs, such as the brain. " ], "offsets": [ [ 281, 495 ] ] }, { "id": "5660", "type": "abstract", "text": [ "MicroRNAs as a molecular basis for mental retardation, Alzheimer's and prion diseases. " ], "offsets": [ [ 496, 584 ] ] }, { "id": "5661", "type": "abstract", "text": [ "MicroRNAs (miRNAs) are small, approximately 21- to 23-nucleotide (nt) non-coding RNA species that act as key regulators of gene expression along a central and well-defined cellular process known as RNA silencing, and involving the recognition and translational control of specific messenger RNA (mRNAs). " ], "offsets": [ [ 585, 889 ] ] }, { "id": "5662", "type": "abstract", "text": [ "Generated through the well-orchestrated and sequential processing of miRNA precursor molecules, mature miRNAs are subsequently incorporated into miRNA-containing ribonucleoprotein effector complexes to regulate mRNA translation through the recognition of specific binding sites of imperfect complementarity located mainly in the 3' untranslated region. " ], "offsets": [ [ 890, 1243 ] ] }, { "id": "5663", "type": "abstract", "text": [ "Predicted to regulate up to 90% of the genes in humans, miRNAs may thus control cellular processes in all cells and tissues of the human body. " ], "offsets": [ [ 1244, 1387 ] ] } ]

[ { "id": "5664", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 85, 91 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d120.s0.e0" } ] }, { "id": "5665", "type": "Diseases", "text": [ "Alzheimer's disease" ], "offsets": [ [ 234, 253 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d120.s0.e1" } ] }, { "id": "5666", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 255, 257 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d120.s0.e2" } ] }, { "id": "5667", "type": "Diseases", "text": [ "prion disease" ], "offsets": [ [ 263, 276 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d120.s0.e3" } ] }, { "id": "5668", "type": "Diseases", "text": [ "fragile X syndrome" ], "offsets": [ [ 214, 232 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d120.s0.e4" } ] }, { "id": "5669", "type": "Relation_Trigger", "text": [ "regulation" ], "offsets": [ [ 99, 109 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d120.s0.e5" } ] }, { "id": "5670", "type": "Diseases", "text": [ "neurodegenerative diseases" ], "offsets": [ [ 148, 174 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d120.s0.e6" } ] }, { "id": "5671", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 350, 355 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d120.s1.e0" } ] }, { "id": "5672", "type": "Relation_Trigger", "text": [ "regulation of gene expression" ], "offsets": [ [ 362, 391 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d120.s1.e1" } ] }, { "id": "5673", "type": "Non-Specific_miRNAs", "text": [ "MicroRNAs" ], "offsets": [ [ 496, 505 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d120.s2.e0" } ] }, { "id": "5674", "type": "Diseases", "text": [ "prion diseases" ], "offsets": [ [ 567, 581 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d120.s2.e1" } ] }, { "id": "5675", "type": "Diseases", "text": [ "Alzheimer's" ], "offsets": [ [ 551, 562 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d120.s2.e2" } ] }, { "id": "5676", "type": "Diseases", "text": [ "mental retardation" ], "offsets": [ [ 531, 549 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d120.s2.e3" } ] }, { "id": "5677", "type": "Non-Specific_miRNAs", "text": [ "MicroRNAs" ], "offsets": [ [ 585, 594 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d120.s3.e0" } ] }, { "id": "5678", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 596, 602 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d120.s3.e1" } ] }, { "id": "5679", "type": "Relation_Trigger", "text": [ "regulators of gene expression" ], "offsets": [ [ 694, 723 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d120.s3.e2" } ] }, { "id": "5680", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 959, 964 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d120.s4.e0" } ] }, { "id": "5681", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 993, 999 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d120.s4.e1" } ] }, { "id": "5682", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1035, 1040 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d120.s4.e2" } ] }, { "id": "5683", "type": "Relation_Trigger", "text": [ "regulate mRNA translation" ], "offsets": [ [ 1092, 1117 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d120.s4.e3" } ] }, { "id": "5684", "type": "Relation_Trigger", "text": [ "binding sites" ], "offsets": [ [ 1154, 1167 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d120.s4.e4" } ] }, { "id": "5685", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1300, 1306 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d120.s5.e0" } ] }, { "id": "5686", "type": "Relation_Trigger", "text": [ "regulate" ], "offsets": [ [ 1257, 1265 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d120.s5.e1" } ] }, { "id": "5687", "type": "Species", "text": [ "humans" ], "offsets": [ [ 1292, 1298 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d120.s5.e2" } ] }, { "id": "5688", "type": "Species", "text": [ "human" ], "offsets": [ [ 1375, 1380 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d120.s5.e3" } ] } ]

[]

[]

[ { "id": "5689", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d120.s0.e0", "arg2_id": "miRNA-corp.d120.s0.e3", "normalized": [] }, { "id": "5690", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d120.s0.e0", "arg2_id": "miRNA-corp.d120.s0.e4", "normalized": [] }, { "id": "5691", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d120.s0.e0", "arg2_id": "miRNA-corp.d120.s0.e6", "normalized": [] }, { "id": "5692", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d120.s0.e0", "arg2_id": "miRNA-corp.d120.s0.e1", "normalized": [] }, { "id": "5693", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d120.s0.e0", "arg2_id": "miRNA-corp.d120.s0.e2", "normalized": [] }, { "id": "5694", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d120.s2.e0", "arg2_id": "miRNA-corp.d120.s2.e2", "normalized": [] }, { "id": "5695", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d120.s2.e0", "arg2_id": "miRNA-corp.d120.s2.e3", "normalized": [] }, { "id": "5696", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d120.s2.e0", "arg2_id": "miRNA-corp.d120.s2.e1", "normalized": [] } ]

[ { "id": "5698", "type": "title", "text": [ "Phosphodiesterase-4D knock-out and RNA interference-mediated knock-down enhance memory and increase hippocampal neurogenesis via increased cAMP signaling. " ], "offsets": [ [ 0, 156 ] ] }, { "id": "5699", "type": "abstract", "text": [ "Phosphodiesterase-4 (PDE4) plays an important role in mediating memory via the control of intracellular cAMP signaling; inhibition of PDE4 enhances memory. " ], "offsets": [ [ 157, 313 ] ] }, { "id": "5700", "type": "abstract", "text": [ "However, development of PDE4 inhibitors as memory enhancers has been hampered by their major side effect of emesis. " ], "offsets": [ [ 314, 430 ] ] }, { "id": "5701", "type": "abstract", "text": [ "PDE4 has four subtypes (PDE4A-D) consisting of 25 splice variants. " ], "offsets": [ [ 431, 498 ] ] }, { "id": "5702", "type": "abstract", "text": [ "Mice deficient in PDE4D displayed memory enhancement in radial arm maze, water maze, and object recognition tests. " ], "offsets": [ [ 499, 614 ] ] }, { "id": "5703", "type": "abstract", "text": [ "These effects were mimicked by repeated treatment with rolipram in wild-type mice. " ], "offsets": [ [ 615, 698 ] ] }, { "id": "5704", "type": "abstract", "text": [ "In addition, similarly as rolipram-treated wild-type mice, PDE4D-deficient mice also displayed increased hippocampal neurogenesis and phosphorylated cAMP response element-binding protein (pCREB). " ], "offsets": [ [ 699, 895 ] ] }, { "id": "5705", "type": "abstract", "text": [ "Furthermore, microinfusion of lentiviral vectors that contained microRNAs (miRNAs) targeting long-form PDE4D isoforms into bilateral dentate gyri of the mouse hippocampus downregulated PDE4D4 and PDE4D5, enhanced memory, and increased hippocampal neurogenesis and pCREB. " ], "offsets": [ [ 896, 1167 ] ] }, { "id": "5706", "type": "abstract", "text": [ "Finally, while rolipram and PDE4D deficiency shortened α2 adrenergic receptor-mediated anesthesia, a surrogate measure of emesis, miRNA-mediated PDE4D knock-down in the hippocampus did not. " ], "offsets": [ [ 1168, 1358 ] ] }, { "id": "5707", "type": "abstract", "text": [ "The present results suggest that PDE4D, in particular long-form PDE4D, plays a critical role in the mediation of memory and hippocampal neurogenesis, which are mediated by cAMP/CREB signaling; reduced expression of PDE4D, or at least PDE4D4 and PDE4D5, in the hippocampus enhances memory but appears not to cause emesis. " ], "offsets": [ [ 1359, 1680 ] ] }, { "id": "5708", "type": "abstract", "text": [ "These novel findings will aid in the development of PDE4 subtype- or variant-selective inhibitors for treatment of disorders involving impaired cognition, including Alzheimer's disease. " ], "offsets": [ [ 1681, 1869 ] ] } ]

[ { "id": "5709", "type": "Genes/Proteins", "text": [ "Phosphodiesterase-4D" ], "offsets": [ [ 0, 20 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d121.s0.e0" } ] }, { "id": "5710", "type": "Genes/Proteins", "text": [ "PDE4" ], "offsets": [ [ 178, 182 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d121.s1.e0" } ] }, { "id": "5711", "type": "Genes/Proteins", "text": [ "PDE4" ], "offsets": [ [ 291, 295 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d121.s1.e1" } ] }, { "id": "5712", "type": "Relation_Trigger", "text": [ "inhibition" ], "offsets": [ [ 277, 287 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d121.s1.e2" } ] }, { "id": "5713", "type": "Genes/Proteins", "text": [ "Phosphodiesterase-4" ], "offsets": [ [ 157, 176 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d121.s1.e3" } ] }, { "id": "5714", "type": "Relation_Trigger", "text": [ "inhibitors" ], "offsets": [ [ 343, 353 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d121.s2.e0" } ] }, { "id": "5715", "type": "Diseases", "text": [ "emesis" ], "offsets": [ [ 422, 428 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d121.s2.e1" } ] }, { "id": "5716", "type": "Genes/Proteins", "text": [ "PDE4" ], "offsets": [ [ 431, 435 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d121.s3.e0" } ] }, { "id": "5717", "type": "Genes/Proteins", "text": [ "PDE4A-D" ], "offsets": [ [ 455, 462 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d121.s3.e1" } ] }, { "id": "5718", "type": "Genes/Proteins", "text": [ "PDE4D" ], "offsets": [ [ 517, 522 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d121.s4.e0" } ] }, { "id": "5719", "type": "Species", "text": [ "Mice" ], "offsets": [ [ 499, 503 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d121.s4.e1" } ] }, { "id": "5720", "type": "Species", "text": [ "mice" ], "offsets": [ [ 692, 696 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d121.s5.e0" } ] }, { "id": "5721", "type": "Genes/Proteins", "text": [ "phosphorylated cAMP response element-binding protein" ], "offsets": [ [ 833, 885 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d121.s6.e0" } ] }, { "id": "5722", "type": "Genes/Proteins", "text": [ "pCREB" ], "offsets": [ [ 887, 892 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d121.s6.e1" } ] }, { "id": "5723", "type": "Genes/Proteins", "text": [ "PDE4D" ], "offsets": [ [ 758, 763 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d121.s6.e2" } ] }, { "id": "5724", "type": "Species", "text": [ "mice" ], "offsets": [ [ 752, 756 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d121.s6.e3" } ] }, { "id": "5725", "type": "Species", "text": [ "mice" ], "offsets": [ [ 774, 778 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d121.s6.e4" } ] }, { "id": "5726", "type": "Non-Specific_miRNAs", "text": [ "microRNAs" ], "offsets": [ [ 960, 969 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d121.s7.e0" } ] }, { "id": "5727", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 971, 977 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d121.s7.e1" } ] }, { "id": "5728", "type": "Genes/Proteins", "text": [ "PDE4D" ], "offsets": [ [ 999, 1004 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d121.s7.e2" } ] }, { "id": "5729", "type": "Genes/Proteins", "text": [ "PDE4D5" ], "offsets": [ [ 1092, 1098 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d121.s7.e3" } ] }, { "id": "5730", "type": "Genes/Proteins", "text": [ "pCREB" ], "offsets": [ [ 1160, 1165 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d121.s7.e4" } ] }, { "id": "5731", "type": "Relation_Trigger", "text": [ "targeting" ], "offsets": [ [ 979, 988 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d121.s7.e5" } ] }, { "id": "5732", "type": "Relation_Trigger", "text": [ "downregulated" ], "offsets": [ [ 1067, 1080 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d121.s7.e6" } ] }, { "id": "5733", "type": "Genes/Proteins", "text": [ "PDE4D4" ], "offsets": [ [ 1081, 1087 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d121.s7.e7" } ] }, { "id": "5734", "type": "Species", "text": [ "mouse" ], "offsets": [ [ 1049, 1054 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d121.s7.e8" } ] }, { "id": "5735", "type": "Genes/Proteins", "text": [ "PDE4D" ], "offsets": [ [ 1196, 1201 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d121.s8.e0" } ] }, { "id": "5736", "type": "Genes/Proteins", "text": [ "PDE4D" ], "offsets": [ [ 1313, 1318 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d121.s8.e1" } ] }, { "id": "5737", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1298, 1303 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d121.s8.e2" } ] }, { "id": "5738", "type": "Diseases", "text": [ "emesis" ], "offsets": [ [ 1290, 1296 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d121.s8.e3" } ] }, { "id": "5739", "type": "Genes/Proteins", "text": [ "PDE4D" ], "offsets": [ [ 1392, 1397 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d121.s9.e0" } ] }, { "id": "5740", "type": "Genes/Proteins", "text": [ "PDE4D" ], "offsets": [ [ 1423, 1428 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d121.s9.e1" } ] }, { "id": "5741", "type": "Genes/Proteins", "text": [ "cAMP" ], "offsets": [ [ 1531, 1535 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d121.s9.e2" } ] }, { "id": "5742", "type": "Genes/Proteins", "text": [ "CREB" ], "offsets": [ [ 1536, 1540 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d121.s9.e3" } ] }, { "id": "5743", "type": "Genes/Proteins", "text": [ "PDE4D" ], "offsets": [ [ 1574, 1579 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d121.s9.e4" } ] }, { "id": "5744", "type": "Genes/Proteins", "text": [ "PDE4D5" ], "offsets": [ [ 1604, 1610 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d121.s9.e5" } ] }, { "id": "5745", "type": "Relation_Trigger", "text": [ "reduced expression" ], "offsets": [ [ 1552, 1570 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d121.s9.e6" } ] }, { "id": "5746", "type": "Diseases", "text": [ "emesis" ], "offsets": [ [ 1672, 1678 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d121.s9.e7" } ] }, { "id": "5747", "type": "Genes/Proteins", "text": [ "PDE4" ], "offsets": [ [ 1733, 1737 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d121.s10.e0" } ] }, { "id": "5748", "type": "Diseases", "text": [ "Alzheimer's disease" ], "offsets": [ [ 1846, 1865 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d121.s10.e1" } ] }, { "id": "5749", "type": "Relation_Trigger", "text": [ "inhibitors" ], "offsets": [ [ 1768, 1778 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d121.s10.e2" } ] } ]

[]

[]

[ { "id": "5750", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d121.s7.e0", "arg2_id": "miRNA-corp.d121.s7.e4", "normalized": [] }, { "id": "5751", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d121.s7.e0", "arg2_id": "miRNA-corp.d121.s7.e7", "normalized": [] }, { "id": "5752", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d121.s7.e0", "arg2_id": "miRNA-corp.d121.s7.e2", "normalized": [] }, { "id": "5753", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d121.s7.e0", "arg2_id": "miRNA-corp.d121.s7.e3", "normalized": [] }, { "id": "5754", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d121.s7.e1", "arg2_id": "miRNA-corp.d121.s7.e4", "normalized": [] }, { "id": "5755", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d121.s7.e1", "arg2_id": "miRNA-corp.d121.s7.e7", "normalized": [] }, { "id": "5756", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d121.s7.e1", "arg2_id": "miRNA-corp.d121.s7.e2", "normalized": [] }, { "id": "5757", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d121.s7.e1", "arg2_id": "miRNA-corp.d121.s7.e3", "normalized": [] }, { "id": "5758", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d121.s8.e2", "arg2_id": "miRNA-corp.d121.s8.e0", "normalized": [] }, { "id": "5759", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d121.s8.e2", "arg2_id": "miRNA-corp.d121.s8.e1", "normalized": [] }, { "id": "5760", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d121.s8.e2", "arg2_id": "miRNA-corp.d121.s8.e3", "normalized": [] } ]

[ { "id": "5762", "type": "title", "text": [ "High levels of high-mobility group A2 expression also significantly correlated with the proliferation marker Ki-67 (P<0.0001). " ], "offsets": [ [ 0, 127 ] ] }, { "id": "5763", "type": "abstract", "text": [ "High levels of high-mobility group A2 expression were more frequently observed in macroadenomas than in microadenomas (P<0.05). " ], "offsets": [ [ 128, 256 ] ] }, { "id": "5764", "type": "abstract", "text": [ "Overexpression of high-mobility group A2 was observed in 39% (38/98) of pituitary adenomas compared with normal adenohypophysial tissue and was frequently found in adenomas including prolactin (PRL), adrenocorticotrophic hormone, or follicle-stimulating hormone/luteinizing hormone and in null cell adenomas, but relatively rare in growth hormone (GH) and mixed GH/PRL adenomas. " ], "offsets": [ [ 257, 636 ] ] }, { "id": "5765", "type": "abstract", "text": [ "High-mobility group A2 expression was significantly associated with tumor invasion (P<0.05) and was significantly higher in grade IV than in grades I, II, and III adenomas (P<0.05). " ], "offsets": [ [ 637, 819 ] ] }, { "id": "5766", "type": "abstract", "text": [ "However, no studies have investigated the clinical significance of high-mobility group A2 and its relationship to the let-7 miRNA family in human pituitary adenomas. " ], "offsets": [ [ 820, 986 ] ] }, { "id": "5767", "type": "abstract", "text": [ "Using immunohistochemistry, we analyzed high-mobility group A2 expression with respect to various clinicopathologic factors in 98 pituitary adenomas. " ], "offsets": [ [ 987, 1137 ] ] }, { "id": "5768", "type": "abstract", "text": [ "Recent studies report that high-mobility group A2 is negatively regulated by the let-7 microRNAs (miRNAs) family in vitro. " ], "offsets": [ [ 1138, 1261 ] ] }, { "id": "5769", "type": "abstract", "text": [ "The development of pituitary adenomas in high-mobility group A2 transgenic mice showed that high-mobility group A2 may be involved in pituitary tumorigenesis. " ], "offsets": [ [ 1262, 1421 ] ] }, { "id": "5770", "type": "abstract", "text": [ "Overexpression of HMGA2 relates to reduction of the let-7 and its relationship to clinicopathological features in pituitary adenomas. " ], "offsets": [ [ 1422, 1557 ] ] }, { "id": "5771", "type": "abstract", "text": [ "High-mobility group A2 is highly expressed during embryogenesis and in various benign and malignant tumors. " ], "offsets": [ [ 1558, 1666 ] ] }, { "id": "5772", "type": "abstract", "text": [ "Real-time quantitative RT-PCR analysis was carried out to evaluate the expression of let-7 in 55 pituitary adenomas. " ], "offsets": [ [ 1667, 1784 ] ] }, { "id": "5773", "type": "abstract", "text": [ "Subsequently, decreased expression of let-7 was confirmed in 23 of 55 (42%) adenomas and was correlated with high-grade tumors (P<0.05). " ], "offsets": [ [ 1785, 1922 ] ] }, { "id": "5774", "type": "abstract", "text": [ "An inverse correlation between let-7 and high-mobility group A2 expression was evident (R=-0.33, P<0.05). " ], "offsets": [ [ 1923, 2029 ] ] }, { "id": "5775", "type": "abstract", "text": [ "These findings support a causal link between let-7 and high-mobility group A2 whereby loss of let-7 expression induces high-mobility group A2 upregulation that represents an important mechanism in pituitary tumorigenesis and progression. " ], "offsets": [ [ 2030, 2270 ] ] } ]

[ { "id": "5776", "type": "Genes/Proteins", "text": [ "high-mobility group A2" ], "offsets": [ [ 15, 37 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s0.e0" } ] }, { "id": "5777", "type": "Relation_Trigger", "text": [ "High levels of high-mobility group A2 expression" ], "offsets": [ [ 0, 48 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s0.e1" } ] }, { "id": "5778", "type": "Relation_Trigger", "text": [ "correlated" ], "offsets": [ [ 68, 78 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s0.e2" } ] }, { "id": "5779", "type": "Genes/Proteins", "text": [ "proliferation marker Ki-67" ], "offsets": [ [ 88, 114 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s0.e3" } ] }, { "id": "5780", "type": "Genes/Proteins", "text": [ "high-mobility group A2" ], "offsets": [ [ 143, 165 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s1.e0" } ] }, { "id": "5781", "type": "Relation_Trigger", "text": [ "High levels of high-mobility group A2 expression" ], "offsets": [ [ 128, 176 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s1.e1" } ] }, { "id": "5782", "type": "Genes/Proteins", "text": [ "PRL" ], "offsets": [ [ 622, 625 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s2.e0" } ] }, { "id": "5783", "type": "Genes/Proteins", "text": [ "prolactin" ], "offsets": [ [ 440, 449 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s2.e1" } ] }, { "id": "5784", "type": "Genes/Proteins", "text": [ "PRL" ], "offsets": [ [ 451, 454 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s2.e2" } ] }, { "id": "5785", "type": "Diseases", "text": [ "pituitary adenomas" ], "offsets": [ [ 329, 347 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s2.e3" } ] }, { "id": "5786", "type": "Genes/Proteins", "text": [ "high-mobility group A2" ], "offsets": [ [ 275, 297 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s2.e4" } ] }, { "id": "5787", "type": "Genes/Proteins", "text": [ "adrenocorticotrophic hormone" ], "offsets": [ [ 457, 485 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s2.e5" } ] }, { "id": "5788", "type": "Genes/Proteins", "text": [ "follicle-stimulating hormone" ], "offsets": [ [ 490, 518 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s2.e6" } ] }, { "id": "5789", "type": "Genes/Proteins", "text": [ "luteinizing hormone" ], "offsets": [ [ 519, 538 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s2.e7" } ] }, { "id": "5790", "type": "Genes/Proteins", "text": [ "growth hormone" ], "offsets": [ [ 589, 603 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s2.e8" } ] }, { "id": "5791", "type": "Relation_Trigger", "text": [ "Overexpression" ], "offsets": [ [ 257, 271 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s2.e9" } ] }, { "id": "5792", "type": "Diseases", "text": [ "adenomas" ], "offsets": [ [ 421, 429 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s2.e10" } ] }, { "id": "5793", "type": "Diseases", "text": [ "adenomas" ], "offsets": [ [ 626, 634 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s2.e11" } ] }, { "id": "5794", "type": "Diseases", "text": [ "adenomas" ], "offsets": [ [ 556, 564 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s2.e12" } ] }, { "id": "5795", "type": "Genes/Proteins", "text": [ "High-mobility group A2" ], "offsets": [ [ 637, 659 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s3.e0" } ] }, { "id": "5796", "type": "Relation_Trigger", "text": [ "associated" ], "offsets": [ [ 689, 699 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s3.e1" } ] }, { "id": "5797", "type": "Diseases", "text": [ "tumor" ], "offsets": [ [ 705, 710 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s3.e2" } ] }, { "id": "5798", "type": "Diseases", "text": [ "adenomas" ], "offsets": [ [ 800, 808 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s3.e3" } ] }, { "id": "5799", "type": "Specific_miRNAs", "text": [ "let-7" ], "offsets": [ [ 938, 943 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s4.e0" } ] }, { "id": "5800", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 944, 949 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s4.e1" } ] }, { "id": "5801", "type": "Diseases", "text": [ "pituitary adenomas" ], "offsets": [ [ 966, 984 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s4.e2" } ] }, { "id": "5802", "type": "Genes/Proteins", "text": [ "high-mobility group A2" ], "offsets": [ [ 887, 909 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s4.e3" } ] }, { "id": "5803", "type": "Species", "text": [ "human" ], "offsets": [ [ 960, 965 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s4.e4" } ] }, { "id": "5804", "type": "Diseases", "text": [ "pituitary adenomas" ], "offsets": [ [ 1117, 1135 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s5.e0" } ] }, { "id": "5805", "type": "Genes/Proteins", "text": [ "high-mobility group A2" ], "offsets": [ [ 1027, 1049 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s5.e1" } ] }, { "id": "5806", "type": "Specific_miRNAs", "text": [ "let-7" ], "offsets": [ [ 1219, 1224 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s6.e0" } ] }, { "id": "5807", "type": "Genes/Proteins", "text": [ "high-mobility group A2" ], "offsets": [ [ 1165, 1187 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s6.e1" } ] }, { "id": "5808", "type": "Non-Specific_miRNAs", "text": [ "microRNAs" ], "offsets": [ [ 1225, 1234 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s6.e2" } ] }, { "id": "5809", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1236, 1242 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s6.e3" } ] }, { "id": "5810", "type": "Relation_Trigger", "text": [ "negatively regulated" ], "offsets": [ [ 1191, 1211 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s6.e4" } ] }, { "id": "5811", "type": "Diseases", "text": [ "pituitary adenomas" ], "offsets": [ [ 1281, 1299 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s7.e0" } ] }, { "id": "5812", "type": "Genes/Proteins", "text": [ "high-mobility group A2" ], "offsets": [ [ 1303, 1325 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s7.e1" } ] }, { "id": "5813", "type": "Genes/Proteins", "text": [ "high-mobility group A2" ], "offsets": [ [ 1354, 1376 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s7.e2" } ] }, { "id": "5814", "type": "Species", "text": [ "transgenic mice" ], "offsets": [ [ 1326, 1341 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s7.e3" } ] }, { "id": "5815", "type": "Genes/Proteins", "text": [ "HMGA2" ], "offsets": [ [ 1440, 1445 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s8.e0" } ] }, { "id": "5816", "type": "Specific_miRNAs", "text": [ "let-7" ], "offsets": [ [ 1474, 1479 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s8.e1" } ] }, { "id": "5817", "type": "Diseases", "text": [ "pituitary adenomas" ], "offsets": [ [ 1536, 1554 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s8.e2" } ] }, { "id": "5818", "type": "Relation_Trigger", "text": [ "Overexpression" ], "offsets": [ [ 1422, 1436 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s8.e3" } ] }, { "id": "5819", "type": "Genes/Proteins", "text": [ "High-mobility group A2" ], "offsets": [ [ 1558, 1580 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s9.e0" } ] }, { "id": "5820", "type": "Diseases", "text": [ "malignant tumors" ], "offsets": [ [ 1648, 1664 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s9.e1" } ] }, { "id": "5821", "type": "Relation_Trigger", "text": [ "highly expressed" ], "offsets": [ [ 1584, 1600 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s9.e2" } ] }, { "id": "5822", "type": "Specific_miRNAs", "text": [ "let-7" ], "offsets": [ [ 1752, 1757 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s10.e0" } ] }, { "id": "5823", "type": "Diseases", "text": [ "pituitary adenomas" ], "offsets": [ [ 1764, 1782 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s10.e1" } ] }, { "id": "5824", "type": "Specific_miRNAs", "text": [ "let-7" ], "offsets": [ [ 1823, 1828 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s11.e0" } ] }, { "id": "5825", "type": "Relation_Trigger", "text": [ "decreased expression" ], "offsets": [ [ 1799, 1819 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s11.e1" } ] }, { "id": "5826", "type": "Diseases", "text": [ "high-grade tumors" ], "offsets": [ [ 1894, 1911 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s11.e2" } ] }, { "id": "5827", "type": "Relation_Trigger", "text": [ "correlated" ], "offsets": [ [ 1878, 1888 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s11.e3" } ] }, { "id": "5828", "type": "Diseases", "text": [ "adenomas" ], "offsets": [ [ 1861, 1869 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s11.e4" } ] }, { "id": "5829", "type": "Specific_miRNAs", "text": [ "let-7" ], "offsets": [ [ 1954, 1959 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s12.e0" } ] }, { "id": "5830", "type": "Genes/Proteins", "text": [ "high-mobility group A2" ], "offsets": [ [ 1964, 1986 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s12.e1" } ] }, { "id": "5831", "type": "Relation_Trigger", "text": [ "inverse correlation" ], "offsets": [ [ 1926, 1945 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s12.e2" } ] }, { "id": "5832", "type": "Specific_miRNAs", "text": [ "let-7" ], "offsets": [ [ 2075, 2080 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s13.e0" } ] }, { "id": "5833", "type": "Specific_miRNAs", "text": [ "let-7" ], "offsets": [ [ 2124, 2129 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s13.e1" } ] }, { "id": "5834", "type": "Genes/Proteins", "text": [ "high-mobility group A2" ], "offsets": [ [ 2149, 2171 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s13.e2" } ] }, { "id": "5835", "type": "Genes/Proteins", "text": [ "high-mobility group A2" ], "offsets": [ [ 2085, 2107 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s13.e3" } ] }, { "id": "5836", "type": "Relation_Trigger", "text": [ "loss of let-7 expression" ], "offsets": [ [ 2116, 2140 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s13.e4" } ] }, { "id": "5837", "type": "Relation_Trigger", "text": [ "upregulation" ], "offsets": [ [ 2172, 2184 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d122.s13.e5" } ] } ]

[]

[]

[ { "id": "5838", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d122.s4.e1", "arg2_id": "miRNA-corp.d122.s4.e2", "normalized": [] }, { "id": "5839", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d122.s4.e1", "arg2_id": "miRNA-corp.d122.s4.e3", "normalized": [] }, { "id": "5840", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d122.s4.e0", "arg2_id": "miRNA-corp.d122.s4.e2", "normalized": [] }, { "id": "5841", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d122.s4.e0", "arg2_id": "miRNA-corp.d122.s4.e3", "normalized": [] }, { "id": "5842", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d122.s6.e0", "arg2_id": "miRNA-corp.d122.s6.e1", "normalized": [] }, { "id": "5843", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d122.s6.e2", "arg2_id": "miRNA-corp.d122.s6.e1", "normalized": [] }, { "id": "5844", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d122.s6.e3", "arg2_id": "miRNA-corp.d122.s6.e1", "normalized": [] }, { "id": "5845", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d122.s8.e1", "arg2_id": "miRNA-corp.d122.s8.e0", "normalized": [] }, { "id": "5846", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d122.s8.e1", "arg2_id": "miRNA-corp.d122.s8.e2", "normalized": [] }, { "id": "5847", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d122.s10.e0", "arg2_id": "miRNA-corp.d122.s10.e1", "normalized": [] }, { "id": "5848", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d122.s11.e0", "arg2_id": "miRNA-corp.d122.s11.e2", "normalized": [] }, { "id": "5849", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d122.s11.e0", "arg2_id": "miRNA-corp.d122.s11.e4", "normalized": [] }, { "id": "5850", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d122.s12.e0", "arg2_id": "miRNA-corp.d122.s12.e1", "normalized": [] }, { "id": "5851", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d122.s13.e0", "arg2_id": "miRNA-corp.d122.s13.e2", "normalized": [] }, { "id": "5852", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d122.s13.e0", "arg2_id": "miRNA-corp.d122.s13.e3", "normalized": [] }, { "id": "5853", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d122.s13.e1", "arg2_id": "miRNA-corp.d122.s13.e2", "normalized": [] }, { "id": "5854", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d122.s13.e1", "arg2_id": "miRNA-corp.d122.s13.e3", "normalized": [] } ]

[ { "id": "5856", "type": "title", "text": [ "MicroRNAs (miRNAs) are known to influence many important cellular processes, including proliferation, apoptosis, neurogenesis, angiogenesis, and morphogenesis, all processes that are involved in TBI pathophysiology. " ], "offsets": [ [ 0, 216 ] ] }, { "id": "5857", "type": "abstract", "text": [ "Multiple cellular, molecular, and biochemical changes contribute to outcome after traumatic brain injury (TBI). " ], "offsets": [ [ 217, 329 ] ] }, { "id": "5858", "type": "abstract", "text": [ "In the present study, we used a microarray platform to examine changes in the hippocampal expression levels of 444 verified rodent miRNAs at 3 and 24 hr after controlled cortical impact injury. " ], "offsets": [ [ 330, 524 ] ] }, { "id": "5859", "type": "abstract", "text": [ "However, it has not yet been determined whether miRNA expression is altered after TBI. " ], "offsets": [ [ 525, 612 ] ] }, { "id": "5860", "type": "abstract", "text": [ "We extended the microarray findings using quantitative polymerase chain reaction analysis for a subset of the miRNAs with altered expression levels (miR-107, -130a, -223, -292-5p, -433-3p, -451, -541, and -711). " ], "offsets": [ [ 613, 825 ] ] }, { "id": "5861", "type": "abstract", "text": [ "Our analysis found 50 miRNAs exhibited decreased expression levels and 35 miRNAs exhibited increased expression levels in the hippocampus after injury. " ], "offsets": [ [ 826, 978 ] ] }, { "id": "5862", "type": "abstract", "text": [ "Our results indicate that multiple protein targets and biological processes involved in TBI pathophysiology may be regulated by miRNAs. " ], "offsets": [ [ 979, 1117 ] ] }, { "id": "5863", "type": "abstract", "text": [ "Bioinformatic analysis of the predicted targets for this panel of miRNAs revealed an overrepresentation of proteins involved in several biological processes and functions known to be initiated after injury, including signal transduction, transcriptional regulation, proliferation, and differentiation. " ], "offsets": [ [ 1118, 1420 ] ] }, { "id": "5864", "type": "abstract", "text": [ "Traumatic brain injury alters expression of hippocampal microRNAs: potential regulators of multiple pathophysiological processes. " ], "offsets": [ [ 1421, 1552 ] ] } ]

[ { "id": "5865", "type": "Diseases", "text": [ "TBI" ], "offsets": [ [ 195, 198 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d123.s0.e0" } ] }, { "id": "5866", "type": "Non-Specific_miRNAs", "text": [ "MicroRNAs" ], "offsets": [ [ 0, 9 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d123.s0.e1" } ] }, { "id": "5867", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 11, 17 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d123.s0.e2" } ] }, { "id": "5868", "type": "Diseases", "text": [ "traumatic brain injury" ], "offsets": [ [ 299, 321 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d123.s1.e0" } ] }, { "id": "5869", "type": "Diseases", "text": [ "TBI" ], "offsets": [ [ 323, 326 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d123.s1.e1" } ] }, { "id": "5870", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 461, 467 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d123.s2.e0" } ] }, { "id": "5871", "type": "Relation_Trigger", "text": [ "changes in the hippocampal expression" ], "offsets": [ [ 393, 430 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d123.s2.e1" } ] }, { "id": "5872", "type": "Diseases", "text": [ "injury" ], "offsets": [ [ 516, 522 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d123.s2.e2" } ] }, { "id": "5873", "type": "Diseases", "text": [ "TBI" ], "offsets": [ [ 607, 610 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d123.s3.e0" } ] }, { "id": "5874", "type": "Relation_Trigger", "text": [ "expression is altered" ], "offsets": [ [ 579, 600 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d123.s3.e1" } ] }, { "id": "5875", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 573, 578 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d123.s3.e2" } ] }, { "id": "5876", "type": "Relation_Trigger", "text": [ "altered expression levels" ], "offsets": [ [ 735, 760 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d123.s4.e0" } ] }, { "id": "5877", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 723, 729 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d123.s4.e1" } ] }, { "id": "5878", "type": "Specific_miRNAs", "text": [ "miR-107, -130a, -223, -292-5p, -433-3p, -451, -541, and -711" ], "offsets": [ [ 762, 822 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d123.s4.e2" } ] }, { "id": "5879", "type": "Relation_Trigger", "text": [ "decreased expression levels" ], "offsets": [ [ 865, 892 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d123.s5.e0" } ] }, { "id": "5880", "type": "Relation_Trigger", "text": [ "increased expression levels" ], "offsets": [ [ 917, 944 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d123.s5.e1" } ] }, { "id": "5881", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 848, 854 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d123.s5.e2" } ] }, { "id": "5882", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 900, 906 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d123.s5.e3" } ] }, { "id": "5883", "type": "Diseases", "text": [ "injury" ], "offsets": [ [ 970, 976 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d123.s5.e4" } ] }, { "id": "5884", "type": "Diseases", "text": [ "TBI" ], "offsets": [ [ 1067, 1070 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d123.s6.e0" } ] }, { "id": "5885", "type": "Relation_Trigger", "text": [ "regulated" ], "offsets": [ [ 1094, 1103 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d123.s6.e1" } ] }, { "id": "5886", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1107, 1113 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d123.s6.e2" } ] }, { "id": "5887", "type": "Relation_Trigger", "text": [ "targets" ], "offsets": [ [ 1022, 1029 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d123.s6.e3" } ] }, { "id": "5888", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1184, 1190 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d123.s7.e0" } ] }, { "id": "5889", "type": "Relation_Trigger", "text": [ "transcriptional regulation" ], "offsets": [ [ 1356, 1382 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d123.s7.e1" } ] }, { "id": "5890", "type": "Relation_Trigger", "text": [ "predicted targets" ], "offsets": [ [ 1148, 1165 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d123.s7.e2" } ] }, { "id": "5891", "type": "Diseases", "text": [ "injury" ], "offsets": [ [ 1317, 1323 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d123.s7.e3" } ] }, { "id": "5892", "type": "Diseases", "text": [ "Traumatic brain injury" ], "offsets": [ [ 1421, 1443 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d123.s8.e0" } ] }, { "id": "5893", "type": "Relation_Trigger", "text": [ "alters expression" ], "offsets": [ [ 1444, 1461 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d123.s8.e1" } ] }, { "id": "5894", "type": "Non-Specific_miRNAs", "text": [ "microRNAs" ], "offsets": [ [ 1477, 1486 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d123.s8.e2" } ] }, { "id": "5895", "type": "Relation_Trigger", "text": [ "potential regulators" ], "offsets": [ [ 1488, 1508 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d123.s8.e3" } ] } ]

[]

[]

[ { "id": "5896", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d123.s0.e1", "arg2_id": "miRNA-corp.d123.s0.e0", "normalized": [] }, { "id": "5897", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d123.s0.e2", "arg2_id": "miRNA-corp.d123.s0.e0", "normalized": [] }, { "id": "5898", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d123.s2.e0", "arg2_id": "miRNA-corp.d123.s2.e2", "normalized": [] }, { "id": "5899", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d123.s3.e2", "arg2_id": "miRNA-corp.d123.s3.e0", "normalized": [] }, { "id": "5900", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d123.s5.e2", "arg2_id": "miRNA-corp.d123.s5.e4", "normalized": [] }, { "id": "5901", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d123.s5.e3", "arg2_id": "miRNA-corp.d123.s5.e4", "normalized": [] }, { "id": "5902", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d123.s6.e2", "arg2_id": "miRNA-corp.d123.s6.e0", "normalized": [] }, { "id": "5903", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d123.s7.e0", "arg2_id": "miRNA-corp.d123.s7.e3", "normalized": [] }, { "id": "5904", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d123.s8.e2", "arg2_id": "miRNA-corp.d123.s8.e0", "normalized": [] } ]

[ { "id": "5906", "type": "title", "text": [ "Potent, allele selective inhibition of HTT by mismatched RNAs provides a new option for developing HD therapeutics. " ], "offsets": [ [ 0, 118 ] ] }, { "id": "5907", "type": "abstract", "text": [ "Switching the RNAi mechanism toward that used by miRNAs by introducing one or more mismatched bases into these duplex RNAs leads to potent (<10 nM) and highly selective (>30-fold relative to wild-type HTT) inhibition of mutant HTT expression in patient-derived cells. " ], "offsets": [ [ 119, 387 ] ] }, { "id": "5908", "type": "abstract", "text": [ "We observe that fully complementary duplex RNAs targeting the expanded CAG repeat within HTT mRNA block expression of both alleles. " ], "offsets": [ [ 388, 520 ] ] }, { "id": "5909", "type": "abstract", "text": [ "An ideal silencing agent would block expression of mutant HTT while leaving expression of wild-type HTT intact. " ], "offsets": [ [ 521, 633 ] ] }, { "id": "5910", "type": "abstract", "text": [ "Inhibiting expression of huntingtin (HTT) protein is a promising strategy for treating Huntington's disease (HD), but indiscriminant inhibition of both wild-type and mutant alleles may lead to toxicity. " ], "offsets": [ [ 634, 837 ] ] }, { "id": "5911", "type": "abstract", "text": [ "Allele-selective inhibition of huntingtin expression by switching to an miRNA-like RNAi mechanism. " ], "offsets": [ [ 838, 938 ] ] } ]

[ { "id": "5912", "type": "Genes/Proteins", "text": [ "HTT" ], "offsets": [ [ 39, 42 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d124.s0.e0" } ] }, { "id": "5913", "type": "Diseases", "text": [ "HD" ], "offsets": [ [ 99, 101 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d124.s0.e1" } ] }, { "id": "5914", "type": "Relation_Trigger", "text": [ "inhibition" ], "offsets": [ [ 25, 35 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d124.s0.e2" } ] }, { "id": "5915", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 168, 174 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d124.s1.e0" } ] }, { "id": "5916", "type": "Relation_Trigger", "text": [ "inhibition of mutant HTT expression" ], "offsets": [ [ 325, 360 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d124.s1.e1" } ] }, { "id": "5917", "type": "Species", "text": [ "patient" ], "offsets": [ [ 364, 371 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d124.s1.e2" } ] }, { "id": "5918", "type": "Genes/Proteins", "text": [ "HTT" ], "offsets": [ [ 320, 323 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d124.s1.e3" } ] }, { "id": "5919", "type": "Genes/Proteins", "text": [ "HTT" ], "offsets": [ [ 477, 480 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d124.s2.e0" } ] }, { "id": "5920", "type": "Relation_Trigger", "text": [ "targeting" ], "offsets": [ [ 436, 445 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d124.s2.e1" } ] }, { "id": "5921", "type": "Relation_Trigger", "text": [ "block expression" ], "offsets": [ [ 486, 502 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d124.s2.e2" } ] }, { "id": "5922", "type": "Genes/Proteins", "text": [ "HTT" ], "offsets": [ [ 621, 624 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d124.s3.e0" } ] }, { "id": "5923", "type": "Relation_Trigger", "text": [ "block expression" ], "offsets": [ [ 552, 568 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d124.s3.e1" } ] }, { "id": "5924", "type": "Genes/Proteins", "text": [ "HTT" ], "offsets": [ [ 671, 674 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d124.s4.e0" } ] }, { "id": "5925", "type": "Genes/Proteins", "text": [ "huntingtin" ], "offsets": [ [ 659, 669 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d124.s4.e1" } ] }, { "id": "5926", "type": "Diseases", "text": [ "Huntington's disease" ], "offsets": [ [ 721, 741 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d124.s4.e2" } ] }, { "id": "5927", "type": "Diseases", "text": [ "HD" ], "offsets": [ [ 743, 745 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d124.s4.e3" } ] }, { "id": "5928", "type": "Relation_Trigger", "text": [ "inhibition" ], "offsets": [ [ 767, 777 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d124.s4.e4" } ] }, { "id": "5929", "type": "Relation_Trigger", "text": [ "Inhibiting expression" ], "offsets": [ [ 634, 655 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d124.s4.e5" } ] }, { "id": "5930", "type": "Genes/Proteins", "text": [ "huntingtin" ], "offsets": [ [ 869, 879 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d124.s5.e0" } ] }, { "id": "5931", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 910, 915 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d124.s5.e1" } ] }, { "id": "5932", "type": "Relation_Trigger", "text": [ "inhibition of huntingtin expression" ], "offsets": [ [ 855, 890 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d124.s5.e2" } ] } ]

[]

[]

[ { "id": "5933", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d124.s1.e0", "arg2_id": "miRNA-corp.d124.s1.e3", "normalized": [] }, { "id": "5934", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d124.s5.e1", "arg2_id": "miRNA-corp.d124.s5.e0", "normalized": [] } ]

[ { "id": "5936", "type": "title", "text": [ "Thus we have identified a miRNA expression signature that can predict GBM patient survival. " ], "offsets": [ [ 0, 92 ] ] }, { "id": "5937", "type": "abstract", "text": [ "Cox multivariate analysis with patient age as a covariate on the entire patient set identified risk score based on the 10 miRNA expression signature to be an independent predictor of patient survival (HR = 1.120; 95% CI = 1.04-1.20; p = 0.003). " ], "offsets": [ [ 93, 338 ] ] }, { "id": "5938", "type": "abstract", "text": [ "These findings may have implications in the understanding of gliomagenesis, development of targeted therapy and selection of high risk cancer patients for adjuvant therapy. " ], "offsets": [ [ 339, 514 ] ] }, { "id": "5939", "type": "abstract", "text": [ "GBM patients with high risk scores had overall poor survival compared to the patients with low risk scores. " ], "offsets": [ [ 515, 623 ] ] }, { "id": "5940", "type": "abstract", "text": [ "Overall survival among the entire patient set was 35.0% at 2 years, 21.5% at 3 years, 18.5% at 4 years and 11.8% at 5 years in the low risk group, versus 11.0%, 5.5%, 0.0 and 0.0% respectively in the high risk group (HR = 2.0; 95% CI = 1.4-2.8; p<0.0001). " ], "offsets": [ [ 624, 880 ] ] }, { "id": "5941", "type": "abstract", "text": [ "To identify a microRNA (miRNA) expression signature that can predict GBM patient survival, we analyzed the miRNA expression data of GBM patients (n = 222) derived from The Cancer Genome Atlas (TCGA) dataset. " ], "offsets": [ [ 881, 1089 ] ] }, { "id": "5942", "type": "abstract", "text": [ "We divided the patients randomly into training and testing sets with equal number in each group. " ], "offsets": [ [ 1090, 1187 ] ] }, { "id": "5943", "type": "abstract", "text": [ "A Ten-microRNA Expression Signature Predicts Survival in Glioblastoma. " ], "offsets": [ [ 1188, 1260 ] ] }, { "id": "5944", "type": "abstract", "text": [ "Glioblastoma (GBM) is the most common and aggressive primary brain tumor with very poor patient median survival. " ], "offsets": [ [ 1261, 1374 ] ] }, { "id": "5945", "type": "abstract", "text": [ "Of these 10 miRNAs, 7 were found to be risky miRNAs and 3 were found to be protective. " ], "offsets": [ [ 1375, 1462 ] ] }, { "id": "5946", "type": "abstract", "text": [ "We identified 10 significant miRNAs using Cox regression analysis on the training set and formulated a risk score based on the expression signature of these miRNAs that segregated the patients into high and low risk groups with significantly different survival times (hazard ratio [HR] = 2.4; 95% CI = 1.4-3.8; p<0.0001). " ], "offsets": [ [ 1463, 1785 ] ] } ]

[ { "id": "5947", "type": "Diseases", "text": [ "GBM" ], "offsets": [ [ 70, 73 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d125.s0.e0" } ] }, { "id": "5948", "type": "Species", "text": [ "patient" ], "offsets": [ [ 74, 81 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d125.s0.e1" } ] }, { "id": "5949", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 26, 31 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d125.s0.e2" } ] }, { "id": "5950", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 215, 220 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d125.s1.e0" } ] }, { "id": "5951", "type": "Species", "text": [ "patient" ], "offsets": [ [ 124, 131 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d125.s1.e1" } ] }, { "id": "5952", "type": "Species", "text": [ "patient" ], "offsets": [ [ 165, 172 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d125.s1.e2" } ] }, { "id": "5953", "type": "Species", "text": [ "patient" ], "offsets": [ [ 276, 283 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d125.s1.e3" } ] }, { "id": "5954", "type": "Relation_Trigger", "text": [ "targeted" ], "offsets": [ [ 430, 438 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d125.s2.e0" } ] }, { "id": "5955", "type": "Diseases", "text": [ "cancer" ], "offsets": [ [ 474, 480 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d125.s2.e1" } ] }, { "id": "5956", "type": "Species", "text": [ "patients" ], "offsets": [ [ 481, 489 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d125.s2.e2" } ] }, { "id": "5957", "type": "Species", "text": [ "patients" ], "offsets": [ [ 592, 600 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d125.s3.e0" } ] }, { "id": "5958", "type": "Diseases", "text": [ "GBM" ], "offsets": [ [ 515, 518 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d125.s3.e1" } ] }, { "id": "5959", "type": "Species", "text": [ "patients" ], "offsets": [ [ 519, 527 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d125.s3.e2" } ] }, { "id": "5960", "type": "Species", "text": [ "patient" ], "offsets": [ [ 658, 665 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d125.s4.e0" } ] }, { "id": "5961", "type": "Non-Specific_miRNAs", "text": [ "microRNA" ], "offsets": [ [ 895, 903 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d125.s5.e0" } ] }, { "id": "5962", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 905, 910 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d125.s5.e1" } ] }, { "id": "5963", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 988, 993 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d125.s5.e2" } ] }, { "id": "5964", "type": "Diseases", "text": [ "GBM" ], "offsets": [ [ 950, 953 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d125.s5.e3" } ] }, { "id": "5965", "type": "Diseases", "text": [ "GBM" ], "offsets": [ [ 1013, 1016 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d125.s5.e4" } ] }, { "id": "5966", "type": "Species", "text": [ "patient" ], "offsets": [ [ 954, 961 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d125.s5.e5" } ] }, { "id": "5967", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1017, 1025 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d125.s5.e6" } ] }, { "id": "5968", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1105, 1113 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d125.s6.e0" } ] }, { "id": "5969", "type": "Diseases", "text": [ "Glioblastoma" ], "offsets": [ [ 1245, 1257 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d125.s7.e0" } ] }, { "id": "5970", "type": "Non-Specific_miRNAs", "text": [ "microRNA" ], "offsets": [ [ 1194, 1202 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d125.s7.e1" } ] }, { "id": "5971", "type": "Diseases", "text": [ "Glioblastoma" ], "offsets": [ [ 1261, 1273 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d125.s8.e0" } ] }, { "id": "5972", "type": "Diseases", "text": [ "GBM" ], "offsets": [ [ 1275, 1278 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d125.s8.e1" } ] }, { "id": "5973", "type": "Diseases", "text": [ "brain tumor" ], "offsets": [ [ 1322, 1333 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d125.s8.e2" } ] }, { "id": "5974", "type": "Species", "text": [ "patient" ], "offsets": [ [ 1349, 1356 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d125.s8.e3" } ] }, { "id": "5975", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1387, 1393 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d125.s9.e0" } ] }, { "id": "5976", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1420, 1426 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d125.s9.e1" } ] }, { "id": "5977", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1492, 1498 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d125.s11.e0" } ] }, { "id": "5978", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1620, 1626 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d125.s11.e1" } ] }, { "id": "5979", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1647, 1655 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d125.s11.e2" } ] } ]

[]

[]

[ { "id": "5980", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d125.s0.e0", "arg2_id": "miRNA-corp.d125.s0.e2", "normalized": [] }, { "id": "5981", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d125.s5.e0", "arg2_id": "miRNA-corp.d125.s5.e3", "normalized": [] }, { "id": "5982", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d125.s5.e0", "arg2_id": "miRNA-corp.d125.s5.e4", "normalized": [] }, { "id": "5983", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d125.s5.e1", "arg2_id": "miRNA-corp.d125.s5.e3", "normalized": [] }, { "id": "5984", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d125.s5.e1", "arg2_id": "miRNA-corp.d125.s5.e4", "normalized": [] }, { "id": "5985", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d125.s5.e2", "arg2_id": "miRNA-corp.d125.s5.e3", "normalized": [] }, { "id": "5986", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d125.s5.e2", "arg2_id": "miRNA-corp.d125.s5.e4", "normalized": [] }, { "id": "5987", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d125.s7.e1", "arg2_id": "miRNA-corp.d125.s7.e0", "normalized": [] } ]

[ { "id": "5989", "type": "title", "text": [ "Microarray analysis showed differential expression of multiple miRNAs in HIVE compared to control brains. " ], "offsets": [ [ 0, 106 ] ] }, { "id": "5990", "type": "abstract", "text": [ "Target prediction and gene ontology enrichment analysis disclosed targeting of several gene families/biological processes by differentially expressed miRNAs (DEMs), with cell death-related genes, including caspase-6, showing a bias toward down-regulated DEMs. " ], "offsets": [ [ 107, 367 ] ] }, { "id": "5991", "type": "abstract", "text": [ "Consistent with the miRNA data, HIVE brains exhibited higher levels of caspase-6 transcripts compared with control patients. " ], "offsets": [ [ 368, 493 ] ] }, { "id": "5992", "type": "abstract", "text": [ "Immunohistochemical analysis showed localization of the cleaved form of caspase-6 in astrocytes in HIVE brain sections. " ], "offsets": [ [ 494, 614 ] ] }, { "id": "5993", "type": "abstract", "text": [ "Exposure of cultured human primary astrocytes to HIV viral protein R (Vpr) induced p53 up-regulation, loss of mitochondrial membrane potential, and caspase-6 activation followed by cell injury. " ], "offsets": [ [ 615, 809 ] ] }, { "id": "5994", "type": "abstract", "text": [ "Transgenic mice, expressing Vpr in microglial cells, demonstrated astrocyte apoptosis in brain, which was associated with caspase-6 activation and neurobehavioral abnormalities. " ], "offsets": [ [ 810, 988 ] ] }, { "id": "5995", "type": "abstract", "text": [ "Overall, these data point to previously unrecognized alterations in miRNA profile in the brain during HIV infection, which contribute to cell death through dysregulation of cell death machinery. " ], "offsets": [ [ 989, 1186 ] ] }, { "id": "5996", "type": "abstract", "text": [ "MicroRNA profiling reveals new aspects of HIV neurodegeneration: caspase-6 regulates astrocyte survival. " ], "offsets": [ [ 1187, 1293 ] ] }, { "id": "5997", "type": "abstract", "text": [ "MicroRNAs (miRNAs) are small noncoding RNA molecules, which are known to regulate gene expression in physiological and pathological conditions. " ], "offsets": [ [ 1294, 1438 ] ] }, { "id": "5998", "type": "abstract", "text": [ "miRNA profiling was performed using brain tissue from patients with HIV encephalitis (HIVE), a neuroinflammatory/degenerative disorder caused by HIV infection of the brain. " ], "offsets": [ [ 1439, 1612 ] ] } ]

[ { "id": "5999", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 63, 69 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d126.s0.e0" } ] }, { "id": "6000", "type": "Diseases", "text": [ "HIVE" ], "offsets": [ [ 73, 77 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d126.s0.e1" } ] }, { "id": "6001", "type": "Relation_Trigger", "text": [ "differential expression" ], "offsets": [ [ 27, 50 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d126.s0.e2" } ] }, { "id": "6002", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 257, 263 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d126.s1.e0" } ] }, { "id": "6003", "type": "Genes/Proteins", "text": [ "caspase-6" ], "offsets": [ [ 313, 322 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d126.s1.e1" } ] }, { "id": "6004", "type": "Relation_Trigger", "text": [ "differentially expressed" ], "offsets": [ [ 232, 256 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d126.s1.e2" } ] }, { "id": "6005", "type": "Relation_Trigger", "text": [ "targeting" ], "offsets": [ [ 173, 182 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d126.s1.e3" } ] }, { "id": "6006", "type": "Relation_Trigger", "text": [ "down-regulated" ], "offsets": [ [ 346, 360 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d126.s1.e4" } ] }, { "id": "6007", "type": "Relation_Trigger", "text": [ "Target" ], "offsets": [ [ 107, 113 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d126.s1.e5" } ] }, { "id": "6008", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 388, 393 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d126.s2.e0" } ] }, { "id": "6009", "type": "Diseases", "text": [ "HIVE" ], "offsets": [ [ 400, 404 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d126.s2.e1" } ] }, { "id": "6010", "type": "Genes/Proteins", "text": [ "caspase-6" ], "offsets": [ [ 439, 448 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d126.s2.e2" } ] }, { "id": "6011", "type": "Relation_Trigger", "text": [ "higher levels" ], "offsets": [ [ 422, 435 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d126.s2.e3" } ] }, { "id": "6012", "type": "Species", "text": [ "patients" ], "offsets": [ [ 483, 491 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d126.s2.e4" } ] }, { "id": "6013", "type": "Genes/Proteins", "text": [ "caspase-6" ], "offsets": [ [ 566, 575 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d126.s3.e0" } ] }, { "id": "6014", "type": "Diseases", "text": [ "HIVE" ], "offsets": [ [ 593, 597 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d126.s3.e1" } ] }, { "id": "6015", "type": "Genes/Proteins", "text": [ "p53" ], "offsets": [ [ 698, 701 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d126.s4.e0" } ] }, { "id": "6016", "type": "Genes/Proteins", "text": [ "caspase-6" ], "offsets": [ [ 763, 772 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d126.s4.e1" } ] }, { "id": "6017", "type": "Relation_Trigger", "text": [ "up-regulation" ], "offsets": [ [ 702, 715 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d126.s4.e2" } ] }, { "id": "6018", "type": "Relation_Trigger", "text": [ "activation" ], "offsets": [ [ 773, 783 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d126.s4.e3" } ] }, { "id": "6019", "type": "Diseases", "text": [ "cell injury" ], "offsets": [ [ 796, 807 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d126.s4.e4" } ] }, { "id": "6020", "type": "Species", "text": [ "human" ], "offsets": [ [ 636, 641 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d126.s4.e5" } ] }, { "id": "6021", "type": "Genes/Proteins", "text": [ "caspase-6" ], "offsets": [ [ 932, 941 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d126.s5.e0" } ] }, { "id": "6022", "type": "Relation_Trigger", "text": [ "associated" ], "offsets": [ [ 916, 926 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d126.s5.e1" } ] }, { "id": "6023", "type": "Relation_Trigger", "text": [ "activation" ], "offsets": [ [ 942, 952 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d126.s5.e2" } ] }, { "id": "6024", "type": "Diseases", "text": [ "neurobehavioral abnormalities" ], "offsets": [ [ 957, 986 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d126.s5.e3" } ] }, { "id": "6025", "type": "Species", "text": [ "Transgenic mice" ], "offsets": [ [ 810, 825 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d126.s5.e4" } ] }, { "id": "6026", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1057, 1062 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d126.s6.e0" } ] }, { "id": "6027", "type": "Diseases", "text": [ "HIV infection" ], "offsets": [ [ 1091, 1104 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d126.s6.e1" } ] }, { "id": "6028", "type": "Relation_Trigger", "text": [ "alterations in miRNA profile" ], "offsets": [ [ 1042, 1070 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d126.s6.e2" } ] }, { "id": "6029", "type": "Relation_Trigger", "text": [ "dysregulation" ], "offsets": [ [ 1145, 1158 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d126.s6.e3" } ] }, { "id": "6030", "type": "Non-Specific_miRNAs", "text": [ "MicroRNA" ], "offsets": [ [ 1187, 1195 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d126.s7.e0" } ] }, { "id": "6031", "type": "Genes/Proteins", "text": [ "caspase-6" ], "offsets": [ [ 1252, 1261 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d126.s7.e1" } ] }, { "id": "6032", "type": "Relation_Trigger", "text": [ "regulates" ], "offsets": [ [ 1262, 1271 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d126.s7.e2" } ] }, { "id": "6033", "type": "Non-Specific_miRNAs", "text": [ "MicroRNAs" ], "offsets": [ [ 1294, 1303 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d126.s8.e0" } ] }, { "id": "6034", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1305, 1311 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d126.s8.e1" } ] }, { "id": "6035", "type": "Relation_Trigger", "text": [ "regulate gene expression" ], "offsets": [ [ 1367, 1391 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d126.s8.e2" } ] }, { "id": "6036", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1439, 1444 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d126.s9.e0" } ] }, { "id": "6037", "type": "Diseases", "text": [ "HIV infection" ], "offsets": [ [ 1584, 1597 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d126.s9.e1" } ] }, { "id": "6038", "type": "Diseases", "text": [ "HIV encephalitis" ], "offsets": [ [ 1507, 1523 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d126.s9.e2" } ] }, { "id": "6039", "type": "Diseases", "text": [ "HIVE" ], "offsets": [ [ 1525, 1529 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d126.s9.e3" } ] }, { "id": "6040", "type": "Diseases", "text": [ "neuroinflammatory/degenerative disorder" ], "offsets": [ [ 1534, 1573 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d126.s9.e4" } ] }, { "id": "6041", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1493, 1501 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d126.s9.e5" } ] } ]

[]

[]

[ { "id": "6042", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d126.s0.e0", "arg2_id": "miRNA-corp.d126.s0.e1", "normalized": [] }, { "id": "6043", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d126.s1.e0", "arg2_id": "miRNA-corp.d126.s1.e1", "normalized": [] }, { "id": "6044", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d126.s2.e0", "arg2_id": "miRNA-corp.d126.s2.e1", "normalized": [] }, { "id": "6045", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d126.s2.e0", "arg2_id": "miRNA-corp.d126.s2.e2", "normalized": [] }, { "id": "6046", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d126.s6.e0", "arg2_id": "miRNA-corp.d126.s6.e1", "normalized": [] }, { "id": "6047", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d126.s7.e0", "arg2_id": "miRNA-corp.d126.s7.e1", "normalized": [] }, { "id": "6048", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d126.s9.e0", "arg2_id": "miRNA-corp.d126.s9.e1", "normalized": [] }, { "id": "6049", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d126.s9.e0", "arg2_id": "miRNA-corp.d126.s9.e2", "normalized": [] }, { "id": "6050", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d126.s9.e0", "arg2_id": "miRNA-corp.d126.s9.e3", "normalized": [] }, { "id": "6051", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d126.s9.e0", "arg2_id": "miRNA-corp.d126.s9.e4", "normalized": [] } ]

[ { "id": "6053", "type": "abstract", "text": [ "Implantation of adult human mesenchymal stem cells (MSCs) to treat neural disorders shows promise. " ], "offsets": [ [ 0, 99 ] ] }, { "id": "6054", "type": "abstract", "text": [ "Depending on their microenvironment, MSCs could potentially be used for the repair and/or replacement of neurons in traumatic brain injury or the treatment of Parkinson's disease. " ], "offsets": [ [ 100, 280 ] ] }, { "id": "6055", "type": "abstract", "text": [ "This cross-disciplinary review incorporates aspects of neuroscience, stem cell biology, cancer biology and immunology to discuss interactions between inflammatory mediators and MSCs. " ], "offsets": [ [ 281, 464 ] ] }, { "id": "6056", "type": "abstract", "text": [ "We first discuss the role of microRNAs (miRNAs) in neurological development. " ], "offsets": [ [ 465, 542 ] ] }, { "id": "6057", "type": "abstract", "text": [ "Neurogenesis: role for microRNAs and mesenchymal stem cells in pathological states. " ], "offsets": [ [ 543, 628 ] ] }, { "id": "6058", "type": "abstract", "text": [ "Exploring the predisposition of MSCs to oncogenesis is critical for translational science since the implementation of safeguarding measures prior to therapy can lead to the successful delivery of stem cells to patients. " ], "offsets": [ [ 629, 849 ] ] }, { "id": "6059", "type": "abstract", "text": [ "Secondly, we discuss the ability of MSCs to transdifferentiate into functional neurons, which are regulated by miRNAs, and the implications of these cells for the therapy of neuropathological states. " ], "offsets": [ [ 850, 1050 ] ] }, { "id": "6060", "type": "abstract", "text": [ "Immune mediators could be central to MSC responses within a region of tissue injury and are also discussed in detail. " ], "offsets": [ [ 1051, 1169 ] ] }, { "id": "6061", "type": "abstract", "text": [ "Thus, we discuss a key gene, RE-1 silencing transcription factor (REST), based on its dual role in neurogenesis and cancer development. " ], "offsets": [ [ 1170, 1306 ] ] } ]

[ { "id": "6062", "type": "Diseases", "text": [ "neural disorders" ], "offsets": [ [ 67, 83 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d127.s1.e0" } ] }, { "id": "6063", "type": "Species", "text": [ "human" ], "offsets": [ [ 22, 27 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d127.s1.e1" } ] }, { "id": "6064", "type": "Diseases", "text": [ "Parkinson's disease" ], "offsets": [ [ 259, 278 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d127.s2.e0" } ] }, { "id": "6065", "type": "Diseases", "text": [ "brain injury" ], "offsets": [ [ 226, 238 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d127.s2.e1" } ] }, { "id": "6066", "type": "Diseases", "text": [ "cancer" ], "offsets": [ [ 369, 375 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d127.s3.e0" } ] }, { "id": "6067", "type": "Non-Specific_miRNAs", "text": [ "microRNAs" ], "offsets": [ [ 494, 503 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d127.s4.e0" } ] }, { "id": "6068", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 505, 511 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d127.s4.e1" } ] }, { "id": "6069", "type": "Non-Specific_miRNAs", "text": [ "microRNAs" ], "offsets": [ [ 566, 575 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d127.s5.e0" } ] }, { "id": "6070", "type": "Species", "text": [ "patients" ], "offsets": [ [ 839, 847 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d127.s6.e0" } ] }, { "id": "6071", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 961, 967 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d127.s8.e0" } ] }, { "id": "6072", "type": "Relation_Trigger", "text": [ "regulated" ], "offsets": [ [ 948, 957 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d127.s8.e1" } ] }, { "id": "6073", "type": "Diseases", "text": [ "tissue injury" ], "offsets": [ [ 1121, 1134 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d127.s9.e0" } ] }, { "id": "6074", "type": "Genes/Proteins", "text": [ "RE-1 silencing transcription factor" ], "offsets": [ [ 1199, 1234 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d127.s10.e0" } ] }, { "id": "6075", "type": "Genes/Proteins", "text": [ "REST" ], "offsets": [ [ 1236, 1240 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d127.s10.e1" } ] }, { "id": "6076", "type": "Diseases", "text": [ "cancer" ], "offsets": [ [ 1286, 1292 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d127.s10.e2" } ] } ]

[]

[]

[]

[ { "id": "6078", "type": "title", "text": [ "Language brain dominance in patients with refractory temporal lobe epilepsy: a comparative study between functional magnetic resonance imaging and dichotic listening test. " ], "offsets": [ [ 0, 173 ] ] }, { "id": "6079", "type": "abstract", "text": [ "PURPOSE: To identify brain dominance for language functions with DLT and correlate these results with those obtained from fMRI in patients suffering from intractable temporal lobe epilepsy. " ], "offsets": [ [ 174, 364 ] ] }, { "id": "6080", "type": "abstract", "text": [ "METHOD: This study reports on 13 patients who underwent pre-surgical epileptic evaluation between April and October 2004 at the Epilepsy Surgery Program, Hospital Sao Lucas, PUCRS. " ], "offsets": [ [ 365, 546 ] ] }, { "id": "6081", "type": "abstract", "text": [ "In DLT, dominance was assessed through a consonant-vowel task, whereas in fMRI patients performed a verb generation task. " ], "offsets": [ [ 547, 669 ] ] }, { "id": "6082", "type": "abstract", "text": [ "These findings indicate that DLT (a non-invasive procedure) could be a useful tool to evaluate language brain dominance in pre-surgical epileptic patients as it is cheaper to perform than fMRI. " ], "offsets": [ [ 670, 866 ] ] }, { "id": "6083", "type": "abstract", "text": [ "CONCLUSION: DLT was found to significantly correlate with fMRI. " ], "offsets": [ [ 867, 931 ] ] }, { "id": "6084", "type": "abstract", "text": [ "RESULTS: Our results identified a correlation between the fMRI lateralization index and the DLT ear predominance index and reply difference index (r=0.6, p=0.02; Pearson Correlation Coefficient), showing positive correlation between results obtained from fMRI and DLT. " ], "offsets": [ [ 932, 1201 ] ] } ]

[ { "id": "6085", "type": "Diseases", "text": [ "refractory temporal lobe epilepsy" ], "offsets": [ [ 42, 75 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d128.s0.e0" } ] }, { "id": "6086", "type": "Species", "text": [ "patients" ], "offsets": [ [ 28, 36 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d128.s0.e1" } ] }, { "id": "6087", "type": "Diseases", "text": [ "intractable temporal lobe epilepsy" ], "offsets": [ [ 328, 362 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d128.s1.e0" } ] }, { "id": "6088", "type": "Relation_Trigger", "text": [ "correlate" ], "offsets": [ [ 247, 256 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d128.s1.e1" } ] }, { "id": "6089", "type": "Species", "text": [ "patients" ], "offsets": [ [ 304, 312 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d128.s1.e2" } ] }, { "id": "6090", "type": "Species", "text": [ "patients" ], "offsets": [ [ 398, 406 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d128.s2.e0" } ] }, { "id": "6091", "type": "Species", "text": [ "patients" ], "offsets": [ [ 626, 634 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d128.s3.e0" } ] }, { "id": "6092", "type": "Species", "text": [ "patients" ], "offsets": [ [ 816, 824 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d128.s4.e0" } ] }, { "id": "6093", "type": "Relation_Trigger", "text": [ "correlate" ], "offsets": [ [ 910, 919 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d128.s5.e0" } ] }, { "id": "6094", "type": "Relation_Trigger", "text": [ "positive correlation" ], "offsets": [ [ 1136, 1156 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d128.s6.e0" } ] }, { "id": "6095", "type": "Relation_Trigger", "text": [ "correlation" ], "offsets": [ [ 966, 977 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d128.s6.e1" } ] } ]

[]

[]

[]

[ { "id": "6097", "type": "title", "text": [ "Finally, a phylogenetic analysis shows that ADCK3 belongs to the family of atypical kinases, which includes phosphoinositide and choline kinases, suggesting that ADCK3 plays an indirect regulatory role in ubiquinone biosynthesis possibly as part of a feedback loop that regulates ATP production. " ], "offsets": [ [ 0, 298 ] ] }, { "id": "6098", "type": "abstract", "text": [ "ADCK3, an ancestral kinase, is mutated in a form of recessive ataxia associated with coenzyme Q10 deficiency. " ], "offsets": [ [ 299, 410 ] ] }, { "id": "6099", "type": "abstract", "text": [ "Muscle coenzyme Q(10) (CoQ(10) or ubiquinone) deficiency has been identified in more than 20 patients with presumed autosomal-recessive ataxia. " ], "offsets": [ [ 411, 555 ] ] }, { "id": "6100", "type": "abstract", "text": [ "However, mutations in genes required for CoQ(10) biosynthetic pathway have been identified only in patients with infantile-onset multisystemic diseases or isolated nephropathy. " ], "offsets": [ [ 556, 733 ] ] }, { "id": "6101", "type": "abstract", "text": [ "Our SNP-based genome-wide scan in a large consanguineous family revealed a locus for autosomal-recessive ataxia at chromosome 1q41. " ], "offsets": [ [ 734, 866 ] ] }, { "id": "6102", "type": "abstract", "text": [ "The causative mutation is a homozygous splice-site mutation in the aarF-domain-containing kinase 3 gene (ADCK3). " ], "offsets": [ [ 867, 980 ] ] }, { "id": "6103", "type": "abstract", "text": [ "Five additional mutations in ADCK3 were found in three patients with sporadic ataxia, including one known to have CoQ(10) deficiency in muscle. " ], "offsets": [ [ 981, 1125 ] ] }, { "id": "6104", "type": "abstract", "text": [ "All of the patients have childhood-onset cerebellar ataxia with slow progression, and three of six have mildly elevated lactate levels. " ], "offsets": [ [ 1126, 1262 ] ] }, { "id": "6105", "type": "abstract", "text": [ "ADCK3 is a mitochondrial protein homologous to the yeast COQ8 and the bacterial UbiB proteins, which are required for CoQ biosynthesis. " ], "offsets": [ [ 1263, 1399 ] ] }, { "id": "6106", "type": "abstract", "text": [ "Three out of four patients tested showed a low endogenous pool of CoQ(10) in their fibroblasts or lymphoblasts, and two out of three patients showed impaired ubiquinone synthesis, strongly suggesting that ADCK3 is also involved in CoQ(10) biosynthesis. " ], "offsets": [ [ 1400, 1653 ] ] }, { "id": "6107", "type": "abstract", "text": [ "The deleterious nature of the three identified missense changes was confirmed by the introduction of them at the corresponding positions of the yeast COQ8 gene. " ], "offsets": [ [ 1654, 1815 ] ] } ]

[ { "id": "6108", "type": "Relation_Trigger", "text": [ "regulatory" ], "offsets": [ [ 186, 196 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d129.s0.e0" } ] }, { "id": "6109", "type": "Genes/Proteins", "text": [ "ADCK3 belongs" ], "offsets": [ [ 44, 57 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d129.s0.e1" } ] }, { "id": "6110", "type": "Genes/Proteins", "text": [ "ADCK3" ], "offsets": [ [ 162, 167 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d129.s0.e2" } ] }, { "id": "6111", "type": "Relation_Trigger", "text": [ "regulates" ], "offsets": [ [ 270, 279 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d129.s0.e3" } ] }, { "id": "6112", "type": "Diseases", "text": [ "recessive ataxia" ], "offsets": [ [ 351, 367 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d129.s1.e0" } ] }, { "id": "6113", "type": "Genes/Proteins", "text": [ "ADCK3" ], "offsets": [ [ 299, 304 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d129.s1.e1" } ] }, { "id": "6114", "type": "Relation_Trigger", "text": [ "associated" ], "offsets": [ [ 368, 378 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d129.s1.e2" } ] }, { "id": "6115", "type": "Diseases", "text": [ "autosomal-recessive ataxia" ], "offsets": [ [ 527, 553 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d129.s2.e0" } ] }, { "id": "6116", "type": "Species", "text": [ "patients" ], "offsets": [ [ 504, 512 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d129.s2.e1" } ] }, { "id": "6117", "type": "Diseases", "text": [ "isolated nephropathy" ], "offsets": [ [ 711, 731 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d129.s3.e0" } ] }, { "id": "6118", "type": "Species", "text": [ "patients" ], "offsets": [ [ 655, 663 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d129.s3.e1" } ] }, { "id": "6119", "type": "Diseases", "text": [ "autosomal-recessive ataxia" ], "offsets": [ [ 819, 845 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d129.s4.e0" } ] }, { "id": "6120", "type": "Genes/Proteins", "text": [ "aarF-domain-containing kinase 3 gene" ], "offsets": [ [ 934, 970 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d129.s5.e0" } ] }, { "id": "6121", "type": "Genes/Proteins", "text": [ "ADCK3" ], "offsets": [ [ 972, 977 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d129.s5.e1" } ] }, { "id": "6122", "type": "Diseases", "text": [ "sporadic ataxia" ], "offsets": [ [ 1050, 1065 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d129.s6.e0" } ] }, { "id": "6123", "type": "Genes/Proteins", "text": [ "ADCK3" ], "offsets": [ [ 1010, 1015 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d129.s6.e1" } ] }, { "id": "6124", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1036, 1044 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d129.s6.e2" } ] }, { "id": "6125", "type": "Relation_Trigger", "text": [ "elevated lactate levels" ], "offsets": [ [ 1237, 1260 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d129.s7.e0" } ] }, { "id": "6126", "type": "Diseases", "text": [ "cerebellar ataxia" ], "offsets": [ [ 1167, 1184 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d129.s7.e1" } ] }, { "id": "6127", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1137, 1145 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d129.s7.e2" } ] }, { "id": "6128", "type": "Genes/Proteins", "text": [ "ADCK3" ], "offsets": [ [ 1263, 1268 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d129.s8.e0" } ] }, { "id": "6129", "type": "Genes/Proteins", "text": [ "COQ8" ], "offsets": [ [ 1320, 1324 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d129.s8.e1" } ] }, { "id": "6130", "type": "Relation_Trigger", "text": [ "impaired" ], "offsets": [ [ 1549, 1557 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d129.s9.e0" } ] }, { "id": "6131", "type": "Genes/Proteins", "text": [ "ADCK3" ], "offsets": [ [ 1605, 1610 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d129.s9.e1" } ] }, { "id": "6132", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1418, 1426 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d129.s9.e2" } ] }, { "id": "6133", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1533, 1541 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d129.s9.e3" } ] }, { "id": "6134", "type": "Genes/Proteins", "text": [ "COQ8" ], "offsets": [ [ 1804, 1808 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d129.s10.e0" } ] } ]

[]

[]

[]

[ { "id": "6136", "type": "title", "text": [ "Our method significantly decreased the duration of hospital admission for monitoring and minimal complications occurred only in 8% of patients. " ], "offsets": [ [ 0, 144 ] ] }, { "id": "6137", "type": "abstract", "text": [ "These qualities, together with good surgery results validate our method for the investigation and treatment of refractory seizure cases. " ], "offsets": [ [ 145, 284 ] ] }, { "id": "6138", "type": "abstract", "text": [ "RESULTS: Our monitoring answered the study question in 88% of the patients. " ], "offsets": [ [ 285, 361 ] ] }, { "id": "6139", "type": "abstract", "text": [ "We prospectively assessed the yield and safety of the telemetry investigation as well as epilepsy surgery outcomes. " ], "offsets": [ [ 362, 478 ] ] }, { "id": "6140", "type": "abstract", "text": [ "Our results changed the management in 74% of cases and potentially improved quality of life by decreasing the AEDs consumption and number of seizures per month. " ], "offsets": [ [ 479, 640 ] ] }, { "id": "6141", "type": "abstract", "text": [ "Over all, 22% received epilepsy surgery and became either seizure free or their seizures became non-disabling. " ], "offsets": [ [ 641, 752 ] ] }, { "id": "6142", "type": "abstract", "text": [ "Over a 2.5-year period, 50 patients that met the indications for VEEG monitoring were admitted by an epileptologist to neuro-observation units with continuous monitoring, nursing coverage and EEG technicians support during working hours and on-call thereafter. " ], "offsets": [ [ 753, 1014 ] ] } ]

[ { "id": "6143", "type": "Relation_Trigger", "text": [ "significantly decreased" ], "offsets": [ [ 11, 34 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d130.s0.e0" } ] }, { "id": "6144", "type": "Species", "text": [ "patients" ], "offsets": [ [ 134, 142 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d130.s0.e1" } ] }, { "id": "6145", "type": "Diseases", "text": [ "refractory seizure" ], "offsets": [ [ 256, 274 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d130.s2.e0" } ] }, { "id": "6146", "type": "Species", "text": [ "patients" ], "offsets": [ [ 351, 359 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d130.s3.e0" } ] }, { "id": "6147", "type": "Diseases", "text": [ "epilepsy" ], "offsets": [ [ 451, 459 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d130.s4.e0" } ] }, { "id": "6148", "type": "Diseases", "text": [ "seizures" ], "offsets": [ [ 620, 628 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d130.s5.e0" } ] }, { "id": "6149", "type": "Diseases", "text": [ "seizure" ], "offsets": [ [ 699, 706 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d130.s7.e0" } ] }, { "id": "6150", "type": "Diseases", "text": [ "seizures" ], "offsets": [ [ 721, 729 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d130.s7.e1" } ] }, { "id": "6151", "type": "Diseases", "text": [ "epilepsy" ], "offsets": [ [ 664, 672 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d130.s7.e2" } ] }, { "id": "6152", "type": "Species", "text": [ "patients" ], "offsets": [ [ 780, 788 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d130.s12.e0" } ] } ]

[]

[]

[]

[ { "id": "6154", "type": "abstract", "text": [ "Gliomas are the most common form of primary brain tumors and are associated with a poor clinical outcome. " ], "offsets": [ [ 0, 106 ] ] }, { "id": "6155", "type": "abstract", "text": [ "microRNAs in gliomas: small regulators of a big problem. " ], "offsets": [ [ 107, 165 ] ] }, { "id": "6156", "type": "abstract", "text": [ "This is a rapidly evolving field and it is likely that we have only begun to appreciate the involvement of microRNAs in relation to glioma formation, and the therapeutic potential of microRNAs to improve outcome for glioma patients. " ], "offsets": [ [ 166, 401 ] ] }, { "id": "6157", "type": "abstract", "text": [ "Here we review the current state of knowledge related to the role of microRNAs in glial tumor development. " ], "offsets": [ [ 402, 509 ] ] }, { "id": "6158", "type": "abstract", "text": [ "It is now evident that microRNAs regulate a wide variety of tumorigenic processes including cellular proliferation, differentiation, angiogenesis, invasion, and apoptosis. " ], "offsets": [ [ 510, 682 ] ] }, { "id": "6159", "type": "abstract", "text": [ "This is particularly true for the role of microRNAs in gliomagenesis, as an appreciation for the significance of aberrant miRNA expression in human cancer has only emerged in the last 5 years. " ], "offsets": [ [ 683, 876 ] ] } ]

[ { "id": "6160", "type": "Diseases", "text": [ "Gliomas" ], "offsets": [ [ 0, 7 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d131.s1.e0" } ] }, { "id": "6161", "type": "Diseases", "text": [ "brain tumors" ], "offsets": [ [ 44, 56 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d131.s1.e1" } ] }, { "id": "6162", "type": "Relation_Trigger", "text": [ "associated" ], "offsets": [ [ 65, 75 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d131.s1.e2" } ] }, { "id": "6163", "type": "Non-Specific_miRNAs", "text": [ "microRNAs" ], "offsets": [ [ 107, 116 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d131.s2.e0" } ] }, { "id": "6164", "type": "Diseases", "text": [ "gliomas" ], "offsets": [ [ 120, 127 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d131.s2.e1" } ] }, { "id": "6165", "type": "Relation_Trigger", "text": [ "regulators" ], "offsets": [ [ 135, 145 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d131.s2.e2" } ] }, { "id": "6166", "type": "Non-Specific_miRNAs", "text": [ "microRNAs" ], "offsets": [ [ 273, 282 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d131.s3.e0" } ] }, { "id": "6167", "type": "Non-Specific_miRNAs", "text": [ "microRNAs" ], "offsets": [ [ 349, 358 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d131.s3.e1" } ] }, { "id": "6168", "type": "Diseases", "text": [ "glioma" ], "offsets": [ [ 298, 304 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d131.s3.e2" } ] }, { "id": "6169", "type": "Diseases", "text": [ "glioma" ], "offsets": [ [ 382, 388 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d131.s3.e3" } ] }, { "id": "6170", "type": "Species", "text": [ "patients" ], "offsets": [ [ 389, 397 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d131.s3.e4" } ] }, { "id": "6171", "type": "Non-Specific_miRNAs", "text": [ "microRNAs" ], "offsets": [ [ 471, 480 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d131.s4.e0" } ] }, { "id": "6172", "type": "Diseases", "text": [ "glial tumor" ], "offsets": [ [ 484, 495 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d131.s4.e1" } ] }, { "id": "6173", "type": "Non-Specific_miRNAs", "text": [ "microRNAs" ], "offsets": [ [ 533, 542 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d131.s5.e0" } ] }, { "id": "6174", "type": "Relation_Trigger", "text": [ "regulate" ], "offsets": [ [ 543, 551 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d131.s5.e1" } ] }, { "id": "6175", "type": "Non-Specific_miRNAs", "text": [ "microRNAs" ], "offsets": [ [ 725, 734 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d131.s6.e0" } ] }, { "id": "6176", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 805, 810 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d131.s6.e1" } ] }, { "id": "6177", "type": "Relation_Trigger", "text": [ "aberrant miRNA expression" ], "offsets": [ [ 796, 821 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d131.s6.e2" } ] }, { "id": "6178", "type": "Diseases", "text": [ "cancer" ], "offsets": [ [ 831, 837 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d131.s6.e3" } ] }, { "id": "6179", "type": "Species", "text": [ "human" ], "offsets": [ [ 825, 830 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d131.s6.e4" } ] } ]

[]

[]

[ { "id": "6180", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d131.s2.e0", "arg2_id": "miRNA-corp.d131.s2.e1", "normalized": [] }, { "id": "6181", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d131.s3.e0", "arg2_id": "miRNA-corp.d131.s3.e2", "normalized": [] }, { "id": "6182", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d131.s3.e0", "arg2_id": "miRNA-corp.d131.s3.e3", "normalized": [] }, { "id": "6183", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d131.s3.e1", "arg2_id": "miRNA-corp.d131.s3.e2", "normalized": [] }, { "id": "6184", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d131.s3.e1", "arg2_id": "miRNA-corp.d131.s3.e3", "normalized": [] }, { "id": "6185", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d131.s4.e0", "arg2_id": "miRNA-corp.d131.s4.e1", "normalized": [] }, { "id": "6186", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d131.s6.e0", "arg2_id": "miRNA-corp.d131.s6.e3", "normalized": [] }, { "id": "6187", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d131.s6.e1", "arg2_id": "miRNA-corp.d131.s6.e3", "normalized": [] } ]

[ { "id": "6189", "type": "title", "text": [ "Moreover, LPS stimulation decreased expression of microRNAs (miRNA)--miR-17-5, miR-20a, and miR-93--which target MICA, implicating a novel role for miRNAs in NKG2D ligand expression. " ], "offsets": [ [ 0, 183 ] ] }, { "id": "6190", "type": "abstract", "text": [ "However, it was not sufficient for surface protein expression, which was controlled posttranscriptionally via a separate pathway involving the ataxia telangiectasia mutated/ataxia telangiectasia and Rad3 related kinases. " ], "offsets": [ [ 184, 405 ] ] }, { "id": "6191", "type": "abstract", "text": [ "Thus, TLR stimulation allows expression of NKG2D ligands through multiple pathways, including downmodulation of specific miRNAs. " ], "offsets": [ [ 406, 537 ] ] }, { "id": "6192", "type": "abstract", "text": [ "In this paper, we clarify that LPS, which ligates TLR-4, preferentially upregulated MICA and not MICB; CL097, which ligates TLR-7/8, upregulated both MICA and MICB; and polyinosinic-polycytidylic acid, which ligates TLR-3, upregulated neither. " ], "offsets": [ [ 538, 782 ] ] }, { "id": "6193", "type": "abstract", "text": [ "However, NKG2D ligands can also be induced on human macrophages by TLR stimulation, which has been far less studied. " ], "offsets": [ [ 783, 900 ] ] }, { "id": "6194", "type": "abstract", "text": [ "This finding suggests that increased levels of MICA mRNA following LPS stimulation resulted from increased transcription. " ], "offsets": [ [ 901, 1023 ] ] }, { "id": "6195", "type": "abstract", "text": [ "To probe how LPS stimulation triggers MICA expression, we determined that the stability of MICA mRNA was much longer than that of MICB mRNA, but neither was changed by LPS stimulation. " ], "offsets": [ [ 1024, 1209 ] ] }, { "id": "6196", "type": "abstract", "text": [ "Multiple mechanisms downstream of TLR-4 stimulation allow expression of NKG2D ligands to facilitate macrophage/NK cell crosstalk. " ], "offsets": [ [ 1210, 1341 ] ] }, { "id": "6197", "type": "abstract", "text": [ "This establishes recognition of \"induced self\" as an important strategy for surveillance of infections or tumor transformation. " ], "offsets": [ [ 1342, 1470 ] ] }, { "id": "6198", "type": "abstract", "text": [ "The activating receptor NKG2D recognizes proteins that are not normally expressed at the surface of most cells but are expressed during a cellular \"stress\" response (e.g., upon induction of the DNA damage pathway). " ], "offsets": [ [ 1471, 1686 ] ] } ]

[ { "id": "6199", "type": "Specific_miRNAs", "text": [ "miR-93" ], "offsets": [ [ 92, 98 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d132.s0.e0" } ] }, { "id": "6200", "type": "Genes/Proteins", "text": [ "MICA" ], "offsets": [ [ 113, 117 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d132.s0.e1" } ] }, { "id": "6201", "type": "Non-Specific_miRNAs", "text": [ "microRNAs" ], "offsets": [ [ 50, 59 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d132.s0.e2" } ] }, { "id": "6202", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 61, 66 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d132.s0.e3" } ] }, { "id": "6203", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 148, 154 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d132.s0.e4" } ] }, { "id": "6204", "type": "Relation_Trigger", "text": [ "decreased expression" ], "offsets": [ [ 26, 46 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d132.s0.e5" } ] }, { "id": "6205", "type": "Relation_Trigger", "text": [ "target" ], "offsets": [ [ 106, 112 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d132.s0.e6" } ] }, { "id": "6206", "type": "Specific_miRNAs", "text": [ "miR-17-5" ], "offsets": [ [ 69, 77 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d132.s0.e7" } ] }, { "id": "6207", "type": "Specific_miRNAs", "text": [ "miR-20a" ], "offsets": [ [ 79, 86 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d132.s0.e8" } ] }, { "id": "6208", "type": "Genes/Proteins", "text": [ "ataxia telangiectasia mutated" ], "offsets": [ [ 327, 356 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d132.s1.e0" } ] }, { "id": "6209", "type": "Genes/Proteins", "text": [ "ataxia telangiectasia and Rad3 related" ], "offsets": [ [ 357, 395 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d132.s1.e1" } ] }, { "id": "6210", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 527, 533 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d132.s2.e0" } ] }, { "id": "6211", "type": "Relation_Trigger", "text": [ "downmodulation" ], "offsets": [ [ 500, 514 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d132.s2.e1" } ] }, { "id": "6212", "type": "Genes/Proteins", "text": [ "TLR-4" ], "offsets": [ [ 588, 593 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d132.s3.e0" } ] }, { "id": "6213", "type": "Genes/Proteins", "text": [ "TLR-3" ], "offsets": [ [ 754, 759 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d132.s3.e1" } ] }, { "id": "6214", "type": "Genes/Proteins", "text": [ "MICA" ], "offsets": [ [ 688, 692 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d132.s3.e2" } ] }, { "id": "6215", "type": "Genes/Proteins", "text": [ "MICB" ], "offsets": [ [ 697, 701 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d132.s3.e3" } ] }, { "id": "6216", "type": "Genes/Proteins", "text": [ "TLR-7/8" ], "offsets": [ [ 662, 669 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d132.s3.e4" } ] }, { "id": "6217", "type": "Genes/Proteins", "text": [ "CL097" ], "offsets": [ [ 641, 646 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d132.s3.e5" } ] }, { "id": "6218", "type": "Genes/Proteins", "text": [ "MICB" ], "offsets": [ [ 635, 639 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d132.s3.e6" } ] }, { "id": "6219", "type": "Genes/Proteins", "text": [ "MICA" ], "offsets": [ [ 622, 626 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d132.s3.e7" } ] }, { "id": "6220", "type": "Relation_Trigger", "text": [ "upregulated" ], "offsets": [ [ 610, 621 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d132.s3.e8" } ] }, { "id": "6221", "type": "Relation_Trigger", "text": [ "upregulated" ], "offsets": [ [ 671, 682 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d132.s3.e9" } ] }, { "id": "6222", "type": "Relation_Trigger", "text": [ "upregulated" ], "offsets": [ [ 761, 772 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d132.s3.e10" } ] }, { "id": "6223", "type": "Species", "text": [ "human" ], "offsets": [ [ 829, 834 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d132.s4.e0" } ] }, { "id": "6224", "type": "Genes/Proteins", "text": [ "MICA" ], "offsets": [ [ 948, 952 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d132.s5.e0" } ] }, { "id": "6225", "type": "Relation_Trigger", "text": [ "increased levels" ], "offsets": [ [ 928, 944 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d132.s5.e1" } ] }, { "id": "6226", "type": "Genes/Proteins", "text": [ "MICA" ], "offsets": [ [ 1115, 1119 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d132.s6.e0" } ] }, { "id": "6227", "type": "Genes/Proteins", "text": [ "MICB" ], "offsets": [ [ 1154, 1158 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d132.s6.e1" } ] }, { "id": "6228", "type": "Genes/Proteins", "text": [ "MICA" ], "offsets": [ [ 1062, 1066 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d132.s6.e2" } ] }, { "id": "6229", "type": "Genes/Proteins", "text": [ "TLR-4" ], "offsets": [ [ 1244, 1249 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d132.s7.e0" } ] }, { "id": "6230", "type": "Diseases", "text": [ "infections" ], "offsets": [ [ 1434, 1444 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d132.s8.e0" } ] }, { "id": "6231", "type": "Diseases", "text": [ "tumor" ], "offsets": [ [ 1448, 1453 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d132.s8.e1" } ] }, { "id": "6232", "type": "Genes/Proteins", "text": [ "NKG2D" ], "offsets": [ [ 1495, 1500 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d132.s9.e0" } ] }, { "id": "6233", "type": "Relation_Trigger", "text": [ "activating" ], "offsets": [ [ 1475, 1485 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d132.s9.e1" } ] }, { "id": "6234", "type": "Diseases", "text": [ "DNA damage" ], "offsets": [ [ 1665, 1675 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d132.s9.e2" } ] } ]

[]

[]

[ { "id": "6235", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d132.s0.e0", "arg2_id": "miRNA-corp.d132.s0.e1", "normalized": [] }, { "id": "6236", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d132.s0.e2", "arg2_id": "miRNA-corp.d132.s0.e1", "normalized": [] }, { "id": "6237", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d132.s0.e3", "arg2_id": "miRNA-corp.d132.s0.e1", "normalized": [] }, { "id": "6238", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d132.s0.e4", "arg2_id": "miRNA-corp.d132.s0.e1", "normalized": [] }, { "id": "6239", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d132.s0.e7", "arg2_id": "miRNA-corp.d132.s0.e1", "normalized": [] }, { "id": "6240", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d132.s0.e8", "arg2_id": "miRNA-corp.d132.s0.e1", "normalized": [] } ]

[ { "id": "6242", "type": "title", "text": [ "MicroRNA in Situ Hybridization in the Human Entorhinal and Transentorhinal Cortex. " ], "offsets": [ [ 0, 84 ] ] }, { "id": "6243", "type": "abstract", "text": [ "MicroRNAs (miRNAs) play key roles in gene expression regulation in both healthy and disease brains. " ], "offsets": [ [ 85, 185 ] ] }, { "id": "6244", "type": "abstract", "text": [ "To better understand those roles, it is necessary to characterize the miRNAs that are expressed in particular cell types under a range of conditions. " ], "offsets": [ [ 186, 336 ] ] }, { "id": "6245", "type": "abstract", "text": [ "In situ hybridization (ISH) can demonstrate cell- and lamina-specific patterns of miRNA expression that would be lost in tissue-level expression profiling. " ], "offsets": [ [ 337, 493 ] ] }, { "id": "6246", "type": "abstract", "text": [ "In the present study, ISH was performed with special focus on the human entorhinal cortex (EC) and transentorhinal cortex (TEC). " ], "offsets": [ [ 494, 623 ] ] }, { "id": "6247", "type": "abstract", "text": [ "The TEC is the area of the cerebral cortex that first develops neurofibrillary tangles in Alzheimer's disease (AD). " ], "offsets": [ [ 624, 740 ] ] }, { "id": "6248", "type": "abstract", "text": [ "However, the reason for TEC's special vulnerability to AD-type pathology is unknown. " ], "offsets": [ [ 741, 826 ] ] }, { "id": "6249", "type": "abstract", "text": [ "MiRNA ISH was performed on three human brains with well-characterized clinical and pathological parameters. " ], "offsets": [ [ 827, 935 ] ] }, { "id": "6250", "type": "abstract", "text": [ "Locked nucleic acid ISH probes were used referent to miR-107, miR-124, miR-125b, and miR-320. " ], "offsets": [ [ 936, 1030 ] ] }, { "id": "6251", "type": "abstract", "text": [ "In order to correlate the ISH data with AD pathology, the ISH staining was compared with near-adjacent slides processed using Thioflavine stains. " ], "offsets": [ [ 1031, 1177 ] ] }, { "id": "6252", "type": "abstract", "text": [ "MiRNA ISH is among the first methods to show special staining characteristics of cells and laminae of the human TEC. " ], "offsets": [ [ 1178, 1297 ] ] }, { "id": "6253", "type": "abstract", "text": [ "As with other areas of brain, the TEC and EC have characteristic miRNA expression patterns. " ], "offsets": [ [ 1298, 1390 ] ] }, { "id": "6254", "type": "abstract", "text": [ "Not all neurons or cortical lamina stain with equal intensity for individual miRNAs. " ], "offsets": [ [ 1391, 1476 ] ] } ]

[ { "id": "6255", "type": "Non-Specific_miRNAs", "text": [ "MicroRNA" ], "offsets": [ [ 0, 8 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d133.s0.e0" } ] }, { "id": "6256", "type": "Species", "text": [ "Human" ], "offsets": [ [ 38, 43 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d133.s0.e1" } ] }, { "id": "6257", "type": "Non-Specific_miRNAs", "text": [ "MicroRNAs" ], "offsets": [ [ 85, 94 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d133.s1.e0" } ] }, { "id": "6258", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 96, 102 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d133.s1.e1" } ] }, { "id": "6259", "type": "Relation_Trigger", "text": [ "expression regulation" ], "offsets": [ [ 127, 148 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d133.s1.e2" } ] }, { "id": "6260", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 256, 262 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d133.s2.e0" } ] }, { "id": "6261", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 419, 424 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d133.s3.e0" } ] }, { "id": "6262", "type": "Species", "text": [ "human" ], "offsets": [ [ 560, 565 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d133.s4.e0" } ] }, { "id": "6263", "type": "Diseases", "text": [ "Alzheimer's disease" ], "offsets": [ [ 714, 733 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d133.s5.e0" } ] }, { "id": "6264", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 735, 737 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d133.s5.e1" } ] }, { "id": "6265", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 796, 798 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d133.s6.e0" } ] }, { "id": "6266", "type": "Non-Specific_miRNAs", "text": [ "MiRNA" ], "offsets": [ [ 827, 832 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d133.s7.e0" } ] }, { "id": "6267", "type": "Species", "text": [ "human" ], "offsets": [ [ 860, 865 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d133.s7.e1" } ] }, { "id": "6268", "type": "Specific_miRNAs", "text": [ "miR-107" ], "offsets": [ [ 989, 996 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d133.s8.e0" } ] }, { "id": "6269", "type": "Specific_miRNAs", "text": [ "miR-124" ], "offsets": [ [ 998, 1005 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d133.s8.e1" } ] }, { "id": "6270", "type": "Specific_miRNAs", "text": [ "miR-125b" ], "offsets": [ [ 1007, 1015 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d133.s8.e2" } ] }, { "id": "6271", "type": "Specific_miRNAs", "text": [ "miR-320" ], "offsets": [ [ 1021, 1028 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d133.s8.e3" } ] }, { "id": "6272", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 1071, 1073 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d133.s9.e0" } ] }, { "id": "6273", "type": "Relation_Trigger", "text": [ "correlate" ], "offsets": [ [ 1043, 1052 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d133.s9.e1" } ] }, { "id": "6274", "type": "Non-Specific_miRNAs", "text": [ "MiRNA" ], "offsets": [ [ 1178, 1183 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d133.s10.e0" } ] }, { "id": "6275", "type": "Species", "text": [ "human" ], "offsets": [ [ 1284, 1289 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d133.s10.e1" } ] }, { "id": "6276", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1363, 1368 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d133.s11.e0" } ] }, { "id": "6277", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1468, 1474 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d133.s12.e0" } ] } ]

[]

[]

[]

[ { "id": "6279", "type": "title", "text": [ "Our in vitro results suggested that Aβ42 oligomer-induced miR-106b leads to impairment in TGF-β signaling through TβR II, concomitant with retinoic acid-induced neurodegeneration in SH-SY5Y cells. " ], "offsets": [ [ 0, 197 ] ] }, { "id": "6280", "type": "abstract", "text": [ "These results show that TβR II is a functional target of miR-106b and that miR-106b may influence TGF-β signaling, thereby contributing to the pathogenesis of AD. " ], "offsets": [ [ 198, 363 ] ] }, { "id": "6281", "type": "abstract", "text": [ "MicroRNAs (miRNAs) are abundantly expressed in the brain and play an important role in disorders of the brain, including Alzheimer's diseases (AD). " ], "offsets": [ [ 364, 512 ] ] }, { "id": "6282", "type": "abstract", "text": [ "miR-106b aberrantly expressed in a double transgenic mouse model for Alzheimer's disease targets TGF-β type II receptor. " ], "offsets": [ [ 513, 635 ] ] }, { "id": "6283", "type": "abstract", "text": [ "However, it is unclear whether miRNAs involved in AD pathogenesis by regulating TGF-β signaling. " ], "offsets": [ [ 636, 733 ] ] }, { "id": "6284", "type": "abstract", "text": [ "Growing body of evidence suggests that the TGF-β signaling pathway plays a key role in the pathogenesis of AD. " ], "offsets": [ [ 734, 845 ] ] }, { "id": "6285", "type": "abstract", "text": [ "Sequence analysis revealed two putative binding sites for miR-106b in the 3' UTR of the TβR II mRNA. " ], "offsets": [ [ 846, 947 ] ] }, { "id": "6286", "type": "abstract", "text": [ "Here we found that miR-106b and TGF-β type II receptor (TβR II) were aberrantly expressed in APPswe/PS∆E9 mice (a double transgenic mouse model for AD). " ], "offsets": [ [ 948, 1101 ] ] }, { "id": "6287", "type": "abstract", "text": [ "After induced neurodifferentiation with all-trans retinoic acid, we observed significant neurodegeneration in SH-SY5Y cells stably transfected with miR-106b. " ], "offsets": [ [ 1102, 1260 ] ] }, { "id": "6288", "type": "abstract", "text": [ "Our results showed that the expression of miR-106b was inversely correlated with TβR II protein levels and miR-106b can directly inhibit the TβR II translation in vitro. " ], "offsets": [ [ 1261, 1431 ] ] }, { "id": "6289", "type": "abstract", "text": [ "Exposure of SH-SY5Y cells to Aβ42 oligomers led to the expression of miR-106b was first increased and then decreased and TβR II levels reduced. " ], "offsets": [ [ 1432, 1576 ] ] }, { "id": "6290", "type": "abstract", "text": [ "Western blot analysis revealed unchanged total Smad2/3 protein levels, but reduced phospho-Smad2/3 (p-Smad2/3) and increased Smad6/7 protein levels in the miR-106b stably transfected cell line. " ], "offsets": [ [ 1577, 1771 ] ] } ]

[ { "id": "6291", "type": "Genes/Proteins", "text": [ "TβR II" ], "offsets": [ [ 114, 120 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s0.e0" } ] }, { "id": "6292", "type": "Specific_miRNAs", "text": [ "miR-106b" ], "offsets": [ [ 58, 66 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s0.e1" } ] }, { "id": "6293", "type": "Relation_Trigger", "text": [ "impairment" ], "offsets": [ [ 76, 86 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s0.e2" } ] }, { "id": "6294", "type": "Genes/Proteins", "text": [ "TGF-β" ], "offsets": [ [ 90, 95 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s0.e3" } ] }, { "id": "6295", "type": "Genes/Proteins", "text": [ "TβR II" ], "offsets": [ [ 222, 228 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s1.e0" } ] }, { "id": "6296", "type": "Specific_miRNAs", "text": [ "miR-106b" ], "offsets": [ [ 273, 281 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s1.e1" } ] }, { "id": "6297", "type": "Specific_miRNAs", "text": [ "miR-106b" ], "offsets": [ [ 255, 263 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s1.e2" } ] }, { "id": "6298", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 357, 359 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s1.e3" } ] }, { "id": "6299", "type": "Relation_Trigger", "text": [ "functional target" ], "offsets": [ [ 234, 251 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s1.e4" } ] }, { "id": "6300", "type": "Genes/Proteins", "text": [ "TGF-β" ], "offsets": [ [ 296, 301 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s1.e5" } ] }, { "id": "6301", "type": "Diseases", "text": [ "Alzheimer's diseases" ], "offsets": [ [ 485, 505 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s2.e0" } ] }, { "id": "6302", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 507, 509 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s2.e1" } ] }, { "id": "6303", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 375, 381 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s2.e2" } ] }, { "id": "6304", "type": "Non-Specific_miRNAs", "text": [ "MicroRNAs" ], "offsets": [ [ 364, 373 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s2.e3" } ] }, { "id": "6305", "type": "Relation_Trigger", "text": [ "abundantly expressed" ], "offsets": [ [ 387, 407 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s2.e3" } ] }, { "id": "6306", "type": "Specific_miRNAs", "text": [ "miR-106b" ], "offsets": [ [ 513, 521 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s3.e0" } ] }, { "id": "6307", "type": "Diseases", "text": [ "Alzheimer's disease" ], "offsets": [ [ 582, 601 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s3.e1" } ] }, { "id": "6308", "type": "Genes/Proteins", "text": [ "TGF-β type II receptor" ], "offsets": [ [ 610, 632 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s3.e2" } ] }, { "id": "6309", "type": "Relation_Trigger", "text": [ "aberrantly expressed" ], "offsets": [ [ 522, 542 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s3.e3" } ] }, { "id": "6310", "type": "Relation_Trigger", "text": [ "targets" ], "offsets": [ [ 602, 609 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s3.e4" } ] }, { "id": "6311", "type": "Species", "text": [ "transgenic mouse" ], "offsets": [ [ 555, 571 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s3.e5" } ] }, { "id": "6312", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 686, 688 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s4.e0" } ] }, { "id": "6313", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 667, 673 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s4.e1" } ] }, { "id": "6314", "type": "Relation_Trigger", "text": [ "regulating" ], "offsets": [ [ 705, 715 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s4.e2" } ] }, { "id": "6315", "type": "Genes/Proteins", "text": [ "TGF-β" ], "offsets": [ [ 716, 721 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s4.e3" } ] }, { "id": "6316", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 841, 843 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s5.e0" } ] }, { "id": "6317", "type": "Genes/Proteins", "text": [ "TGF-β" ], "offsets": [ [ 777, 782 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s5.e1" } ] }, { "id": "6318", "type": "Genes/Proteins", "text": [ "TβR II" ], "offsets": [ [ 934, 940 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s6.e0" } ] }, { "id": "6319", "type": "Specific_miRNAs", "text": [ "miR-106b" ], "offsets": [ [ 904, 912 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s6.e1" } ] }, { "id": "6320", "type": "Relation_Trigger", "text": [ "binding sites" ], "offsets": [ [ 886, 899 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s6.e2" } ] }, { "id": "6321", "type": "Genes/Proteins", "text": [ "TGF-β type II receptor" ], "offsets": [ [ 980, 1002 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s7.e0" } ] }, { "id": "6322", "type": "Genes/Proteins", "text": [ "TβR II" ], "offsets": [ [ 1004, 1010 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s7.e1" } ] }, { "id": "6323", "type": "Specific_miRNAs", "text": [ "miR-106b" ], "offsets": [ [ 967, 975 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s7.e2" } ] }, { "id": "6324", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 1096, 1098 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s7.e3" } ] }, { "id": "6325", "type": "Relation_Trigger", "text": [ "aberrantly expressed" ], "offsets": [ [ 1017, 1037 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s7.e4" } ] }, { "id": "6326", "type": "Species", "text": [ "transgenic mouse" ], "offsets": [ [ 1069, 1085 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s7.e5" } ] }, { "id": "6327", "type": "Species", "text": [ "mice" ], "offsets": [ [ 1054, 1058 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s7.e6" } ] }, { "id": "6328", "type": "Specific_miRNAs", "text": [ "miR-106b" ], "offsets": [ [ 1250, 1258 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s8.e0" } ] }, { "id": "6329", "type": "Genes/Proteins", "text": [ "TβR II" ], "offsets": [ [ 1342, 1348 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s9.e0" } ] }, { "id": "6330", "type": "Genes/Proteins", "text": [ "TβR II" ], "offsets": [ [ 1402, 1408 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s9.e1" } ] }, { "id": "6331", "type": "Specific_miRNAs", "text": [ "miR-106b" ], "offsets": [ [ 1303, 1311 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s9.e2" } ] }, { "id": "6332", "type": "Specific_miRNAs", "text": [ "miR-106b" ], "offsets": [ [ 1368, 1376 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s9.e3" } ] }, { "id": "6333", "type": "Relation_Trigger", "text": [ "inversely correlated" ], "offsets": [ [ 1316, 1336 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s9.e4" } ] }, { "id": "6334", "type": "Relation_Trigger", "text": [ "inhibit the TβR II translation" ], "offsets": [ [ 1390, 1420 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s9.e5" } ] }, { "id": "6335", "type": "Specific_miRNAs", "text": [ "miR-106b" ], "offsets": [ [ 1501, 1509 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s10.e0" } ] }, { "id": "6336", "type": "Genes/Proteins", "text": [ "TβR II" ], "offsets": [ [ 1553, 1559 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s10.e1" } ] }, { "id": "6337", "type": "Relation_Trigger", "text": [ "levels reduced" ], "offsets": [ [ 1560, 1574 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s10.e2" } ] }, { "id": "6338", "type": "Relation_Trigger", "text": [ "expression of miR-106b was first increased" ], "offsets": [ [ 1487, 1529 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s10.e3" } ] }, { "id": "6339", "type": "Genes/Proteins", "text": [ "phospho-Smad2/3" ], "offsets": [ [ 1660, 1675 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s11.e0" } ] }, { "id": "6340", "type": "Genes/Proteins", "text": [ "p-Smad2/3" ], "offsets": [ [ 1677, 1686 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s11.e1" } ] }, { "id": "6341", "type": "Genes/Proteins", "text": [ "Smad2/3" ], "offsets": [ [ 1624, 1631 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s11.e2" } ] }, { "id": "6342", "type": "Genes/Proteins", "text": [ "Smad6/7" ], "offsets": [ [ 1702, 1709 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s11.e3" } ] }, { "id": "6343", "type": "Specific_miRNAs", "text": [ "miR-106b" ], "offsets": [ [ 1732, 1740 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s11.e4" } ] }, { "id": "6344", "type": "Relation_Trigger", "text": [ "increased Smad6/7 protein levels" ], "offsets": [ [ 1692, 1724 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d134.s11.e5" } ] } ]

[]

[]

[ { "id": "6345", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d134.s0.e1", "arg2_id": "miRNA-corp.d134.s0.e0", "normalized": [] }, { "id": "6346", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d134.s0.e1", "arg2_id": "miRNA-corp.d134.s0.e3", "normalized": [] }, { "id": "6347", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d134.s1.e1", "arg2_id": "miRNA-corp.d134.s1.e0", "normalized": [] }, { "id": "6348", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d134.s1.e1", "arg2_id": "miRNA-corp.d134.s1.e3", "normalized": [] }, { "id": "6349", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d134.s1.e1", "arg2_id": "miRNA-corp.d134.s1.e5", "normalized": [] }, { "id": "6350", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d134.s1.e2", "arg2_id": "miRNA-corp.d134.s1.e0", "normalized": [] }, { "id": "6351", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d134.s1.e2", "arg2_id": "miRNA-corp.d134.s1.e3", "normalized": [] }, { "id": "6352", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d134.s1.e2", "arg2_id": "miRNA-corp.d134.s1.e5", "normalized": [] }, { "id": "6353", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d134.s2.e2", "arg2_id": "miRNA-corp.d134.s2.e0", "normalized": [] }, { "id": "6354", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d134.s2.e2", "arg2_id": "miRNA-corp.d134.s2.e1", "normalized": [] }, { "id": "6355", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d134.s2.e3", "arg2_id": "miRNA-corp.d134.s2.e0", "normalized": [] }, { "id": "6356", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d134.s2.e3", "arg2_id": "miRNA-corp.d134.s2.e1", "normalized": [] }, { "id": "6357", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d134.s3.e0", "arg2_id": "miRNA-corp.d134.s3.e1", "normalized": [] }, { "id": "6358", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d134.s3.e0", "arg2_id": "miRNA-corp.d134.s3.e2", "normalized": [] }, { "id": "6359", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d134.s4.e1", "arg2_id": "miRNA-corp.d134.s4.e0", "normalized": [] }, { "id": "6360", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d134.s4.e1", "arg2_id": "miRNA-corp.d134.s4.e3", "normalized": [] }, { "id": "6361", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d134.s6.e1", "arg2_id": "miRNA-corp.d134.s6.e0", "normalized": [] }, { "id": "6362", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d134.s7.e2", "arg2_id": "miRNA-corp.d134.s7.e3", "normalized": [] }, { "id": "6363", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d134.s7.e2", "arg2_id": "miRNA-corp.d134.s7.e0", "normalized": [] }, { "id": "6364", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d134.s7.e2", "arg2_id": "miRNA-corp.d134.s7.e1", "normalized": [] }, { "id": "6365", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d134.s9.e2", "arg2_id": "miRNA-corp.d134.s9.e0", "normalized": [] }, { "id": "6366", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d134.s9.e2", "arg2_id": "miRNA-corp.d134.s9.e1", "normalized": [] }, { "id": "6367", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d134.s9.e3", "arg2_id": "miRNA-corp.d134.s9.e0", "normalized": [] }, { "id": "6368", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d134.s9.e3", "arg2_id": "miRNA-corp.d134.s9.e1", "normalized": [] }, { "id": "6369", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d134.s10.e0", "arg2_id": "miRNA-corp.d134.s10.e1", "normalized": [] }, { "id": "6370", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d134.s11.e4", "arg2_id": "miRNA-corp.d134.s11.e0", "normalized": [] }, { "id": "6371", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d134.s11.e4", "arg2_id": "miRNA-corp.d134.s11.e1", "normalized": [] }, { "id": "6372", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d134.s11.e4", "arg2_id": "miRNA-corp.d134.s11.e2", "normalized": [] }, { "id": "6373", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d134.s11.e4", "arg2_id": "miRNA-corp.d134.s11.e3", "normalized": [] } ]

[ { "id": "6375", "type": "title", "text": [ "Nuclear factor TDP-43 can affect selected microRNA levels. " ], "offsets": [ [ 0, 60 ] ] }, { "id": "6376", "type": "abstract", "text": [ "TDP-43 has recently been described as the major component of the inclusions found in the brain of patients with a variety of neurodegenerative diseases, such as frontotemporal lobar degeneration and amyotrophic lateral sclerosis. " ], "offsets": [ [ 61, 291 ] ] }, { "id": "6377", "type": "abstract", "text": [ "Apart from its involvement in transcription, splicing and mRNA stability, TDP-43 has also been described as a Drosha-associated protein. " ], "offsets": [ [ 292, 429 ] ] }, { "id": "6378", "type": "abstract", "text": [ "TDP-43 is a ubiquitous protein whose specific functions are probably crucial to establishing its pathogenic role. " ], "offsets": [ [ 430, 544 ] ] }, { "id": "6379", "type": "abstract", "text": [ "Here we report for the first time which changes occur in the total miRNA population following TDP-43 knockdown in culture cells. " ], "offsets": [ [ 545, 674 ] ] }, { "id": "6380", "type": "abstract", "text": [ "However, our knowledge of the role of TDP-43 in the microRNA (miRNA) synthesis pathway is limited to the association mentioned above. " ], "offsets": [ [ 675, 809 ] ] }, { "id": "6381", "type": "abstract", "text": [ "Interestingly, both miRNAs are capable of binding directly to TDP-43 in different positions: within the miRNA sequence itself (let-7b) or in the hairpin precursor (miR-663). " ], "offsets": [ [ 810, 984 ] ] }, { "id": "6382", "type": "abstract", "text": [ "In particular, we have observed that let-7b and miR-663 expression levels are down- and upregulated, respectively. " ], "offsets": [ [ 985, 1100 ] ] }, { "id": "6383", "type": "abstract", "text": [ "Using microarray data and real-time PCR we have also identified several candidate transcripts whose expression levels are selectively affected by these TDP-43-miRNA interactions. " ], "offsets": [ [ 1101, 1282 ] ] } ]

[ { "id": "6384", "type": "Genes/Proteins", "text": [ "TDP-43" ], "offsets": [ [ 15, 21 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d135.s0.e0" } ] }, { "id": "6385", "type": "Non-Specific_miRNAs", "text": [ "microRNA" ], "offsets": [ [ 42, 50 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d135.s0.e1" } ] }, { "id": "6386", "type": "Relation_Trigger", "text": [ "affect selected microRNA levels" ], "offsets": [ [ 26, 57 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d135.s0.e2" } ] }, { "id": "6387", "type": "Genes/Proteins", "text": [ "TDP-43" ], "offsets": [ [ 61, 67 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d135.s1.e0" } ] }, { "id": "6388", "type": "Diseases", "text": [ "amyotrophic lateral sclerosis" ], "offsets": [ [ 260, 289 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d135.s1.e1" } ] }, { "id": "6389", "type": "Diseases", "text": [ "frontotemporal lobar degeneration" ], "offsets": [ [ 222, 255 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d135.s1.e2" } ] }, { "id": "6390", "type": "Diseases", "text": [ "neurodegenerative diseases" ], "offsets": [ [ 186, 212 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d135.s1.e3" } ] }, { "id": "6391", "type": "Species", "text": [ "patients" ], "offsets": [ [ 159, 167 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d135.s1.e4" } ] }, { "id": "6392", "type": "Genes/Proteins", "text": [ "TDP-43" ], "offsets": [ [ 366, 372 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d135.s2.e0" } ] }, { "id": "6393", "type": "Genes/Proteins", "text": [ "Drosha" ], "offsets": [ [ 402, 408 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d135.s2.e1" } ] }, { "id": "6394", "type": "Genes/Proteins", "text": [ "TDP-43" ], "offsets": [ [ 430, 436 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d135.s3.e0" } ] }, { "id": "6395", "type": "Genes/Proteins", "text": [ "TDP-43" ], "offsets": [ [ 639, 645 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d135.s4.e0" } ] }, { "id": "6396", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 612, 617 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d135.s4.e1" } ] }, { "id": "6397", "type": "Genes/Proteins", "text": [ "TDP-43" ], "offsets": [ [ 713, 719 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d135.s5.e0" } ] }, { "id": "6398", "type": "Relation_Trigger", "text": [ "association" ], "offsets": [ [ 780, 791 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d135.s5.e1" } ] }, { "id": "6399", "type": "Non-Specific_miRNAs", "text": [ "microRNA" ], "offsets": [ [ 727, 735 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d135.s5.e2" } ] }, { "id": "6400", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 737, 742 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d135.s5.e3" } ] }, { "id": "6401", "type": "Specific_miRNAs", "text": [ "miR-663" ], "offsets": [ [ 974, 981 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d135.s6.e0" } ] }, { "id": "6402", "type": "Genes/Proteins", "text": [ "TDP-43" ], "offsets": [ [ 872, 878 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d135.s6.e1" } ] }, { "id": "6403", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 830, 836 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d135.s6.e2" } ] }, { "id": "6404", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 914, 919 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d135.s6.e3" } ] }, { "id": "6405", "type": "Specific_miRNAs", "text": [ "let-7b" ], "offsets": [ [ 937, 943 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d135.s6.e4" } ] }, { "id": "6406", "type": "Relation_Trigger", "text": [ "binding" ], "offsets": [ [ 852, 859 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d135.s6.e5" } ] }, { "id": "6407", "type": "Specific_miRNAs", "text": [ "let-7b" ], "offsets": [ [ 1022, 1028 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d135.s7.e0" } ] }, { "id": "6408", "type": "Specific_miRNAs", "text": [ "miR-663" ], "offsets": [ [ 1033, 1040 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d135.s7.e1" } ] }, { "id": "6409", "type": "Relation_Trigger", "text": [ "levels are down- and upregulated" ], "offsets": [ [ 1052, 1084 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d135.s7.e2" } ] }, { "id": "6410", "type": "Genes/Proteins", "text": [ "TDP-43" ], "offsets": [ [ 1253, 1259 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d135.s8.e0" } ] }, { "id": "6411", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1260, 1265 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d135.s8.e1" } ] }, { "id": "6412", "type": "Relation_Trigger", "text": [ "expression levels are selectively affected" ], "offsets": [ [ 1201, 1243 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d135.s8.e2" } ] } ]

[]

[]

[ { "id": "6413", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d135.s0.e1", "arg2_id": "miRNA-corp.d135.s0.e0", "normalized": [] }, { "id": "6414", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d135.s4.e1", "arg2_id": "miRNA-corp.d135.s4.e0", "normalized": [] }, { "id": "6415", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d135.s5.e2", "arg2_id": "miRNA-corp.d135.s5.e0", "normalized": [] }, { "id": "6416", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d135.s5.e3", "arg2_id": "miRNA-corp.d135.s5.e0", "normalized": [] }, { "id": "6417", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d135.s6.e2", "arg2_id": "miRNA-corp.d135.s6.e1", "normalized": [] }, { "id": "6418", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d135.s6.e3", "arg2_id": "miRNA-corp.d135.s6.e1", "normalized": [] }, { "id": "6419", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d135.s6.e4", "arg2_id": "miRNA-corp.d135.s6.e1", "normalized": [] }, { "id": "6420", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d135.s6.e0", "arg2_id": "miRNA-corp.d135.s6.e1", "normalized": [] }, { "id": "6421", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d135.s8.e1", "arg2_id": "miRNA-corp.d135.s8.e0", "normalized": [] } ]

[ { "id": "6423", "type": "title", "text": [ "Altered microRNA expression following traumatic spinal cord injury. " ], "offsets": [ [ 0, 69 ] ] }, { "id": "6424", "type": "abstract", "text": [ "MicroRNAs (miRNAs) are a novel class of small non-coding RNAs that negatively regulate gene expression at the posttranscriptional level by binding to the 3' untranslated region of target mRNAs leading to their translational inhibition or sometimes degradation. " ], "offsets": [ [ 70, 331 ] ] }, { "id": "6425", "type": "abstract", "text": [ "We uncovered a previously unknown alteration in temporal expression of a large set of miRNAs following a contusive spinal cord injury (SCI) in adult rats using microarray analysis. " ], "offsets": [ [ 332, 513 ] ] }, { "id": "6426", "type": "abstract", "text": [ "These altered miRNAs can be classified into 3 categories: (1) up-regulation, (2) down-regulation and (3) an early up-regulation at 4 h followed by down-regulation at 1 and 7 days post-SCI. " ], "offsets": [ [ 514, 703 ] ] }, { "id": "6427", "type": "abstract", "text": [ "The bioinformatics analysis indicates that the potential targets for miRNAs altered after SCI include genes encoding components that are involved in the inflammation, oxidation, and apoptosis that are known to play important roles in the pathogenesis of SCI. " ], "offsets": [ [ 704, 963 ] ] }, { "id": "6428", "type": "abstract", "text": [ "These findings suggest that abnormal expression of miRNAs may contribute to the pathogenesis of SCI and are potential targets for therapeutic interventions following SCI. " ], "offsets": [ [ 964, 1137 ] ] } ]

[ { "id": "6429", "type": "Non-Specific_miRNAs", "text": [ "microRNA" ], "offsets": [ [ 8, 16 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d136.s0.e0" } ] }, { "id": "6430", "type": "Diseases", "text": [ "traumatic spinal cord injury" ], "offsets": [ [ 38, 66 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d136.s0.e1" } ] }, { "id": "6431", "type": "Relation_Trigger", "text": [ "Altered microRNA expression" ], "offsets": [ [ 0, 27 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d136.s0.e2" } ] }, { "id": "6432", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 81, 87 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d136.s1.e0" } ] }, { "id": "6433", "type": "Non-Specific_miRNAs", "text": [ "MicroRNAs" ], "offsets": [ [ 70, 79 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d136.s1.e1" } ] }, { "id": "6434", "type": "Relation_Trigger", "text": [ "target" ], "offsets": [ [ 250, 256 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d136.s1.e2" } ] }, { "id": "6435", "type": "Relation_Trigger", "text": [ "translational inhibition" ], "offsets": [ [ 280, 304 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d136.s1.e3" } ] }, { "id": "6436", "type": "Relation_Trigger", "text": [ "regulate gene expression" ], "offsets": [ [ 148, 172 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d136.s1.e4" } ] }, { "id": "6437", "type": "Relation_Trigger", "text": [ "binding" ], "offsets": [ [ 209, 216 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d136.s1.e5" } ] }, { "id": "6438", "type": "Relation_Trigger", "text": [ "negatively regulate" ], "offsets": [ [ 137, 156 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d136.s1.e6" } ] }, { "id": "6439", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 418, 424 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d136.s2.e0" } ] }, { "id": "6440", "type": "Diseases", "text": [ "spinal cord injury" ], "offsets": [ [ 447, 465 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d136.s2.e1" } ] }, { "id": "6441", "type": "Diseases", "text": [ "SCI" ], "offsets": [ [ 467, 470 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d136.s2.e2" } ] }, { "id": "6442", "type": "Relation_Trigger", "text": [ "alteration in temporal expression" ], "offsets": [ [ 366, 399 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d136.s2.e3" } ] }, { "id": "6443", "type": "Species", "text": [ "rats" ], "offsets": [ [ 481, 485 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d136.s2.e4" } ] }, { "id": "6444", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 528, 534 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d136.s3.e0" } ] }, { "id": "6445", "type": "Diseases", "text": [ "SCI" ], "offsets": [ [ 698, 701 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d136.s3.e1" } ] }, { "id": "6446", "type": "Relation_Trigger", "text": [ "up-regulation" ], "offsets": [ [ 576, 589 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d136.s3.e2" } ] }, { "id": "6447", "type": "Relation_Trigger", "text": [ "down-regulation" ], "offsets": [ [ 595, 610 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d136.s3.e3" } ] }, { "id": "6448", "type": "Relation_Trigger", "text": [ "up-regulation" ], "offsets": [ [ 628, 641 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d136.s3.e4" } ] }, { "id": "6449", "type": "Relation_Trigger", "text": [ "down-regulation" ], "offsets": [ [ 661, 676 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d136.s3.e5" } ] }, { "id": "6450", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 773, 779 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d136.s4.e0" } ] }, { "id": "6451", "type": "Diseases", "text": [ "SCI" ], "offsets": [ [ 794, 797 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d136.s4.e1" } ] }, { "id": "6452", "type": "Diseases", "text": [ "SCI" ], "offsets": [ [ 958, 961 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d136.s4.e2" } ] }, { "id": "6453", "type": "Relation_Trigger", "text": [ "potential targets" ], "offsets": [ [ 751, 768 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d136.s4.e3" } ] }, { "id": "6454", "type": "Diseases", "text": [ "inflammation" ], "offsets": [ [ 857, 869 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d136.s4.e4" } ] }, { "id": "6455", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1015, 1021 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d136.s5.e0" } ] }, { "id": "6456", "type": "Diseases", "text": [ "SCI" ], "offsets": [ [ 1060, 1063 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d136.s5.e1" } ] }, { "id": "6457", "type": "Diseases", "text": [ "SCI" ], "offsets": [ [ 1130, 1133 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d136.s5.e2" } ] }, { "id": "6458", "type": "Relation_Trigger", "text": [ "abnormal expression" ], "offsets": [ [ 992, 1011 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d136.s5.e3" } ] }, { "id": "6459", "type": "Relation_Trigger", "text": [ "potential targets" ], "offsets": [ [ 1072, 1089 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d136.s5.e4" } ] }, { "id": "6460", "type": "Relation_Trigger", "text": [ "targets for therapeutic" ], "offsets": [ [ 1082, 1105 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d136.s5.e5" } ] } ]

[]

[]

[ { "id": "6461", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d136.s0.e0", "arg2_id": "miRNA-corp.d136.s0.e1", "normalized": [] }, { "id": "6462", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d136.s2.e0", "arg2_id": "miRNA-corp.d136.s2.e1", "normalized": [] }, { "id": "6463", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d136.s2.e0", "arg2_id": "miRNA-corp.d136.s2.e2", "normalized": [] }, { "id": "6464", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d136.s3.e0", "arg2_id": "miRNA-corp.d136.s3.e1", "normalized": [] }, { "id": "6465", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d136.s4.e0", "arg2_id": "miRNA-corp.d136.s4.e1", "normalized": [] }, { "id": "6466", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d136.s4.e0", "arg2_id": "miRNA-corp.d136.s4.e2", "normalized": [] }, { "id": "6467", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d136.s4.e0", "arg2_id": "miRNA-corp.d136.s4.e4", "normalized": [] }, { "id": "6468", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d136.s5.e0", "arg2_id": "miRNA-corp.d136.s5.e1", "normalized": [] }, { "id": "6469", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d136.s5.e0", "arg2_id": "miRNA-corp.d136.s5.e2", "normalized": [] } ]

[ { "id": "6471", "type": "title", "text": [ "Demyelinating process may be the feature of nervous impairment in systemic lupus erythematosus, Behcet's disease (BD), Sjoegren's syndrome (SS), systemic sclerosis (SSc) or very rarely other systemic autoimmune diseases. " ], "offsets": [ [ 0, 221 ] ] }, { "id": "6472", "type": "abstract", "text": [ "An acute isolated neurological syndrome, as the most common symptom of MS can sometimes be the only feature or even first manifestation of nervous impairment in connective tissue disease, hence presenting the diagnostic problem. " ], "offsets": [ [ 222, 451 ] ] }, { "id": "6473", "type": "abstract", "text": [ "Although the white matter abnormalities seen by magnetic resonance imaging may be similar in non-MS autoimmune demyelination and MS, it is the most important diagnostic tool in the differential diagnosis of the mentioned conditions. " ], "offsets": [ [ 452, 685 ] ] }, { "id": "6474", "type": "abstract", "text": [ "Investigating the presence of various autoantibodies potentially involved in the pathogenesis of demyelinating lesions as well as cerebrospinal fluid (CSF) analysis can be helpful. " ], "offsets": [ [ 686, 869 ] ] }, { "id": "6475", "type": "abstract", "text": [ "Connective tissue diseases can be characterised by central nervous system (CNS) involvement, in some patients manifested by demyelination areas in the white matter of the brain and spinal cord, which are difficult to differentiate from multiple sclerosis (MS) and other demyelinating processes, such as transverse myelitis and optic neuritis. " ], "offsets": [ [ 870, 1213 ] ] } ]

[ { "id": "6476", "type": "Diseases", "text": [ "systemic autoimmune diseases" ], "offsets": [ [ 191, 219 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d137.s0.e0" } ] }, { "id": "6477", "type": "Diseases", "text": [ "Behcet's disease" ], "offsets": [ [ 96, 112 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d137.s0.e1" } ] }, { "id": "6478", "type": "Diseases", "text": [ "BD" ], "offsets": [ [ 114, 116 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d137.s0.e2" } ] }, { "id": "6479", "type": "Diseases", "text": [ "Sjoegren's syndrome" ], "offsets": [ [ 119, 138 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d137.s0.e3" } ] }, { "id": "6480", "type": "Diseases", "text": [ "SS" ], "offsets": [ [ 140, 142 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d137.s0.e4" } ] }, { "id": "6481", "type": "Diseases", "text": [ "systemic sclerosis" ], "offsets": [ [ 145, 163 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d137.s0.e5" } ] }, { "id": "6482", "type": "Diseases", "text": [ "SSc" ], "offsets": [ [ 165, 168 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d137.s0.e6" } ] }, { "id": "6483", "type": "Relation_Trigger", "text": [ "impairment" ], "offsets": [ [ 52, 62 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d137.s0.e7" } ] }, { "id": "6484", "type": "Diseases", "text": [ "systemic lupus erythematosus" ], "offsets": [ [ 66, 94 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d137.s0.e8" } ] }, { "id": "6485", "type": "Diseases", "text": [ "nervous impairment" ], "offsets": [ [ 361, 379 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d137.s1.e0" } ] }, { "id": "6486", "type": "Diseases", "text": [ "MS" ], "offsets": [ [ 293, 295 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d137.s1.e1" } ] }, { "id": "6487", "type": "Relation_Trigger", "text": [ "impairment" ], "offsets": [ [ 369, 379 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d137.s1.e2" } ] }, { "id": "6488", "type": "Diseases", "text": [ "connective tissue disease" ], "offsets": [ [ 383, 408 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d137.s1.e3" } ] }, { "id": "6489", "type": "Diseases", "text": [ "neurological syndrome" ], "offsets": [ [ 240, 261 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d137.s1.e4" } ] }, { "id": "6490", "type": "Diseases", "text": [ "MS" ], "offsets": [ [ 581, 583 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d137.s2.e0" } ] }, { "id": "6491", "type": "Diseases", "text": [ "demyelinating lesions" ], "offsets": [ [ 783, 804 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d137.s3.e0" } ] }, { "id": "6492", "type": "Diseases", "text": [ "multiple sclerosis" ], "offsets": [ [ 1106, 1124 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d137.s5.e0" } ] }, { "id": "6493", "type": "Diseases", "text": [ "MS" ], "offsets": [ [ 1126, 1128 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d137.s5.e1" } ] }, { "id": "6494", "type": "Diseases", "text": [ "demyelination" ], "offsets": [ [ 994, 1007 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d137.s5.e2" } ] }, { "id": "6495", "type": "Diseases", "text": [ "Connective tissue diseases" ], "offsets": [ [ 870, 896 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d137.s5.e3" } ] }, { "id": "6496", "type": "Diseases", "text": [ "optic neuritis" ], "offsets": [ [ 1197, 1211 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d137.s5.e4" } ] }, { "id": "6497", "type": "Diseases", "text": [ "transverse myelitis" ], "offsets": [ [ 1173, 1192 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d137.s5.e5" } ] }, { "id": "6498", "type": "Species", "text": [ "patients" ], "offsets": [ [ 971, 979 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d137.s5.e6" } ] } ]

[]

[]

[]

[ { "id": "6500", "type": "title", "text": [ "Targeting miRNAs in Alzheimer's disease. " ], "offsets": [ [ 0, 45 ] ] } ]

[ { "id": "6501", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 10, 16 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d138.s0.e0" } ] }, { "id": "6502", "type": "Diseases", "text": [ "Alzheimer's disease" ], "offsets": [ [ 20, 39 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d138.s0.e1" } ] }, { "id": "6503", "type": "Relation_Trigger", "text": [ "Targeting" ], "offsets": [ [ 0, 9 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d138.s0.e2" } ] } ]

[]

[]

[ { "id": "6504", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d138.s0.e0", "arg2_id": "miRNA-corp.d138.s0.e1", "normalized": [] } ]

[ { "id": "6506", "type": "title", "text": [ "CONCLUSIONS: These results demonstrate that tissue-specific miRNAs may serve as diagnostically sensitive plasma biomarkers of tissue injury. " ], "offsets": [ [ 0, 143 ] ] }, { "id": "6507", "type": "abstract", "text": [ "The miR-124 concentration increased in the plasma of rats 8 h after surgery to produce brain injury and peaked at 24 h, while the miR-122 and miR-133a concentrations remained at baseline values. " ], "offsets": [ [ 144, 339 ] ] }, { "id": "6508", "type": "abstract", "text": [ "Furthermore, miR-122 exhibited a diagnostic sensitivity superior to that of ALT when the results were correlated to the liver histopathologic results. " ], "offsets": [ [ 340, 491 ] ] }, { "id": "6509", "type": "abstract", "text": [ "Plasma MicroRNAs as sensitive and specific biomarkers of tissue injury. " ], "offsets": [ [ 492, 565 ] ] }, { "id": "6510", "type": "abstract", "text": [ "BACKGROUND: MicroRNAs (miRNAs) are endogenous, small noncoding RNAs. " ], "offsets": [ [ 566, 635 ] ] }, { "id": "6511", "type": "abstract", "text": [ "Because of their size, abundance, tissue specificity, and relative stability in plasma, miRNAs hold promise as unique accessible biomarkers to monitor tissue injury. " ], "offsets": [ [ 636, 802 ] ] }, { "id": "6512", "type": "abstract", "text": [ "METHODS: We investigated the use of liver-, muscle- and brain-specific miRNAs as circulating biomarkers of tissue injury. " ], "offsets": [ [ 803, 925 ] ] }, { "id": "6513", "type": "abstract", "text": [ "We used a highly sensitive quantitative PCR assay to measure specific miRNAs (miR-122, miR-133a, and miR-124) in plasma samples from rats treated with liver or muscle toxicants and from a rat surgical model of stroke. " ], "offsets": [ [ 926, 1144 ] ] }, { "id": "6514", "type": "abstract", "text": [ "RESULTS: We observed increases in plasma concentrations of miR-122, miR-133a, and miR-124 corresponding to injuries in liver, muscle, and brain, respectively. " ], "offsets": [ [ 1145, 1304 ] ] }, { "id": "6515", "type": "abstract", "text": [ "miR-122 and miR-133a illustrated specificity for liver and muscle toxicity, respectively, because they were not detectable in the plasma of animals with toxicity to the other organ. " ], "offsets": [ [ 1305, 1487 ] ] }, { "id": "6516", "type": "abstract", "text": [ "This result contrasted with the results for alanine aminotransferase (ALT) and aspartate aminotransferase, which were both increased with either organ toxicity. " ], "offsets": [ [ 1488, 1649 ] ] } ]

[ { "id": "6517", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 60, 66 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d139.s0.e0" } ] }, { "id": "6518", "type": "Diseases", "text": [ "tissue injury" ], "offsets": [ [ 126, 139 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d139.s0.e1" } ] }, { "id": "6519", "type": "Specific_miRNAs", "text": [ "miR-124" ], "offsets": [ [ 148, 155 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d139.s1.e0" } ] }, { "id": "6520", "type": "Specific_miRNAs", "text": [ "miR-133a" ], "offsets": [ [ 286, 294 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d139.s1.e1" } ] }, { "id": "6521", "type": "Specific_miRNAs", "text": [ "miR-122" ], "offsets": [ [ 274, 281 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d139.s1.e2" } ] }, { "id": "6522", "type": "Diseases", "text": [ "brain injury" ], "offsets": [ [ 231, 243 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d139.s1.e3" } ] }, { "id": "6523", "type": "Relation_Trigger", "text": [ "concentrations remained at baseline values" ], "offsets": [ [ 295, 337 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d139.s1.e4" } ] }, { "id": "6524", "type": "Relation_Trigger", "text": [ "concentration increased" ], "offsets": [ [ 156, 179 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d139.s1.e5" } ] }, { "id": "6525", "type": "Species", "text": [ "rats" ], "offsets": [ [ 197, 201 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d139.s1.e6" } ] }, { "id": "6526", "type": "Specific_miRNAs", "text": [ "miR-122" ], "offsets": [ [ 353, 360 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d139.s2.e0" } ] }, { "id": "6527", "type": "Relation_Trigger", "text": [ "correlated" ], "offsets": [ [ 442, 452 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d139.s2.e1" } ] }, { "id": "6528", "type": "Non-Specific_miRNAs", "text": [ "MicroRNAs" ], "offsets": [ [ 499, 508 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d139.s3.e0" } ] }, { "id": "6529", "type": "Diseases", "text": [ "tissue injury" ], "offsets": [ [ 549, 562 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d139.s3.e1" } ] }, { "id": "6530", "type": "Non-Specific_miRNAs", "text": [ "MicroRNAs" ], "offsets": [ [ 578, 587 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d139.s4.e0" } ] }, { "id": "6531", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 589, 595 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d139.s4.e1" } ] }, { "id": "6532", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 724, 730 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d139.s5.e0" } ] }, { "id": "6533", "type": "Diseases", "text": [ "tissue injury" ], "offsets": [ [ 787, 800 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d139.s5.e1" } ] }, { "id": "6534", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 874, 880 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d139.s6.e0" } ] }, { "id": "6535", "type": "Diseases", "text": [ "tissue injury" ], "offsets": [ [ 910, 923 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d139.s6.e1" } ] }, { "id": "6536", "type": "Specific_miRNAs", "text": [ "miR-122" ], "offsets": [ [ 1004, 1011 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d139.s7.e0" } ] }, { "id": "6537", "type": "Specific_miRNAs", "text": [ "miR-133a" ], "offsets": [ [ 1013, 1021 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d139.s7.e1" } ] }, { "id": "6538", "type": "Specific_miRNAs", "text": [ "miR-124" ], "offsets": [ [ 1027, 1034 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d139.s7.e2" } ] }, { "id": "6539", "type": "Diseases", "text": [ "stroke" ], "offsets": [ [ 1136, 1142 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d139.s7.e3" } ] }, { "id": "6540", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 996, 1002 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d139.s7.e4" } ] }, { "id": "6541", "type": "Species", "text": [ "rats" ], "offsets": [ [ 1059, 1063 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d139.s7.e5" } ] }, { "id": "6542", "type": "Species", "text": [ "rat" ], "offsets": [ [ 1114, 1117 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d139.s7.e6" } ] }, { "id": "6543", "type": "Specific_miRNAs", "text": [ "miR-122" ], "offsets": [ [ 1204, 1211 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d139.s8.e0" } ] }, { "id": "6544", "type": "Specific_miRNAs", "text": [ "miR-133a" ], "offsets": [ [ 1213, 1221 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d139.s8.e1" } ] }, { "id": "6545", "type": "Specific_miRNAs", "text": [ "miR-124" ], "offsets": [ [ 1227, 1234 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d139.s8.e2" } ] }, { "id": "6546", "type": "Diseases", "text": [ "injuries in liver" ], "offsets": [ [ 1252, 1269 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d139.s8.e3" } ] }, { "id": "6547", "type": "Relation_Trigger", "text": [ "increases in plasma concentrations" ], "offsets": [ [ 1166, 1200 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d139.s8.e4" } ] }, { "id": "6548", "type": "Specific_miRNAs", "text": [ "miR-122" ], "offsets": [ [ 1305, 1312 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d139.s9.e0" } ] }, { "id": "6549", "type": "Specific_miRNAs", "text": [ "miR-133a" ], "offsets": [ [ 1317, 1325 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d139.s9.e1" } ] }, { "id": "6550", "type": "Genes/Proteins", "text": [ "alanine aminotransferase" ], "offsets": [ [ 1532, 1556 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d139.s10.e0" } ] }, { "id": "6551", "type": "Genes/Proteins", "text": [ "aspartate aminotransferase" ], "offsets": [ [ 1567, 1593 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d139.s10.e1" } ] } ]

[]

[]

[ { "id": "6552", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d139.s0.e0", "arg2_id": "miRNA-corp.d139.s0.e1", "normalized": [] }, { "id": "6553", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d139.s1.e1", "arg2_id": "miRNA-corp.d139.s1.e3", "normalized": [] }, { "id": "6554", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d139.s1.e2", "arg2_id": "miRNA-corp.d139.s1.e3", "normalized": [] }, { "id": "6555", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d139.s1.e0", "arg2_id": "miRNA-corp.d139.s1.e3", "normalized": [] }, { "id": "6556", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d139.s3.e0", "arg2_id": "miRNA-corp.d139.s3.e1", "normalized": [] }, { "id": "6557", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d139.s5.e0", "arg2_id": "miRNA-corp.d139.s5.e1", "normalized": [] }, { "id": "6558", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d139.s6.e0", "arg2_id": "miRNA-corp.d139.s6.e1", "normalized": [] }, { "id": "6559", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d139.s7.e0", "arg2_id": "miRNA-corp.d139.s7.e3", "normalized": [] }, { "id": "6560", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d139.s7.e1", "arg2_id": "miRNA-corp.d139.s7.e3", "normalized": [] }, { "id": "6561", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d139.s7.e4", "arg2_id": "miRNA-corp.d139.s7.e3", "normalized": [] }, { "id": "6562", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d139.s7.e2", "arg2_id": "miRNA-corp.d139.s7.e3", "normalized": [] }, { "id": "6563", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d139.s8.e0", "arg2_id": "miRNA-corp.d139.s8.e3", "normalized": [] }, { "id": "6564", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d139.s8.e1", "arg2_id": "miRNA-corp.d139.s8.e3", "normalized": [] }, { "id": "6565", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d139.s8.e2", "arg2_id": "miRNA-corp.d139.s8.e3", "normalized": [] } ]

[ { "id": "6567", "type": "title", "text": [ "Atrial fibrillation (AF) is an emerging clinical problem with multifaceted issues: current and expected prevalence, significant morbidity, potentially fatal outcome (e.g., stroke) and gaps in therapeutic approaches. " ], "offsets": [ [ 0, 216 ] ] }, { "id": "6568", "type": "abstract", "text": [ "Targeting the arrhythmogenic substrate in atrial fibrillation: focus on structural remodeling. " ], "offsets": [ [ 217, 313 ] ] }, { "id": "6569", "type": "abstract", "text": [ "Current anti-arrhythmic strategies not only fail to guarantee effective rhythm control, but also cause \"on target\" (i.e., pro-arrhythmia, namely torsade de pointes) and \"off target\" (i.e., extra-cardiac toxicities) side effects. " ], "offsets": [ [ 314, 543 ] ] }, { "id": "6570", "type": "abstract", "text": [ "Fascinating and innovative strategies have been proposed (e.g., miRNAs modulation), but the actual benefit is debated. " ], "offsets": [ [ 544, 663 ] ] }, { "id": "6571", "type": "abstract", "text": [ "This review will provide mechanistic insights into structural remodeling and highlight emerging upstream strategies in AF management. " ], "offsets": [ [ 664, 800 ] ] }, { "id": "6572", "type": "abstract", "text": [ "A body of evidence has emerged supporting structural remodeling as the main arrhythmogenic substrate perpetuating AF. Fibrosis, inflammation and oxidative stress appear strongly interconnected in the pathogenesis of remodeling-induced abnormalities. " ], "offsets": [ [ 801, 1051 ] ] }, { "id": "6573", "type": "abstract", "text": [ "Therefore, pharmacological modulation of non-ionic targets (the so called \"upstream\" therapy) has gained interest as a preventive strategy in AF. " ], "offsets": [ [ 1052, 1198 ] ] }, { "id": "6574", "type": "abstract", "text": [ "At the present state of knowledge, renin-angiotensin-aldosterone system blockers and statins offer evidence for potential clinical exploitation, while several remodeling-targeted therapies have been tested only experimentally or failed when studied for human validation. " ], "offsets": [ [ 1199, 1470 ] ] } ]

[ { "id": "6575", "type": "Diseases", "text": [ "Atrial fibrillation" ], "offsets": [ [ 0, 19 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d140.s0.e0" } ] }, { "id": "6576", "type": "Diseases", "text": [ "AF" ], "offsets": [ [ 21, 23 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d140.s0.e1" } ] }, { "id": "6577", "type": "Diseases", "text": [ "stroke" ], "offsets": [ [ 172, 178 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d140.s0.e2" } ] }, { "id": "6578", "type": "Relation_Trigger", "text": [ "Targeting" ], "offsets": [ [ 217, 226 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d140.s1.e0" } ] }, { "id": "6579", "type": "Diseases", "text": [ "atrial fibrillation" ], "offsets": [ [ 259, 278 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d140.s1.e1" } ] }, { "id": "6580", "type": "Diseases", "text": [ "arrhythmia" ], "offsets": [ [ 440, 450 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d140.s3.e0" } ] }, { "id": "6581", "type": "Relation_Trigger", "text": [ "target" ], "offsets": [ [ 421, 427 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d140.s3.e1" } ] }, { "id": "6582", "type": "Relation_Trigger", "text": [ "target" ], "offsets": [ [ 488, 494 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d140.s3.e2" } ] }, { "id": "6583", "type": "Diseases", "text": [ "torsade de pointes" ], "offsets": [ [ 459, 477 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d140.s3.e3" } ] }, { "id": "6584", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 608, 614 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d140.s4.e0" } ] }, { "id": "6585", "type": "Relation_Trigger", "text": [ "modulation" ], "offsets": [ [ 615, 625 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d140.s4.e1" } ] }, { "id": "6586", "type": "Diseases", "text": [ "AF" ], "offsets": [ [ 783, 785 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d140.s5.e0" } ] }, { "id": "6587", "type": "Diseases", "text": [ "AF" ], "offsets": [ [ 915, 917 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d140.s6.e0" } ] }, { "id": "6588", "type": "Diseases", "text": [ "Fibrosis" ], "offsets": [ [ 919, 927 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d140.s6.e1" } ] }, { "id": "6589", "type": "Diseases", "text": [ "inflammation" ], "offsets": [ [ 929, 941 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d140.s6.e2" } ] }, { "id": "6590", "type": "Diseases", "text": [ "AF" ], "offsets": [ [ 1194, 1196 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d140.s8.e0" } ] }, { "id": "6591", "type": "Relation_Trigger", "text": [ "modulation" ], "offsets": [ [ 1079, 1089 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d140.s8.e1" } ] }, { "id": "6592", "type": "Relation_Trigger", "text": [ "targets" ], "offsets": [ [ 1103, 1110 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d140.s8.e2" } ] }, { "id": "6593", "type": "Genes/Proteins", "text": [ "angiotensin" ], "offsets": [ [ 1240, 1251 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d140.s9.e0" } ] }, { "id": "6594", "type": "Genes/Proteins", "text": [ "renin" ], "offsets": [ [ 1234, 1239 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d140.s9.e1" } ] }, { "id": "6595", "type": "Species", "text": [ "human" ], "offsets": [ [ 1452, 1457 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d140.s9.e2" } ] } ]

[]

[]

[]

[ { "id": "6597", "type": "title", "text": [ "Epigenetics are defined, in broad-terms, as alterations in gene expression without changes in DNA sequence. " ], "offsets": [ [ 0, 108 ] ] }, { "id": "6598", "type": "abstract", "text": [ "Epigenetic changes in gliomas. " ], "offsets": [ [ 109, 141 ] ] }, { "id": "6599", "type": "abstract", "text": [ "In this review, we will first describe briefly histone modifications, DNA methylation and miRNAs and the functions of these epigenetic marks during different cellular processes involving DNA metabolism. " ], "offsets": [ [ 142, 345 ] ] }, { "id": "6600", "type": "abstract", "text": [ "While histone modifications and DNA methylation are two classical means to regulate gene expression, miRNA has also recently been documented to govern gene expression in normal as well as cancer cells. " ], "offsets": [ [ 346, 548 ] ] }, { "id": "6601", "type": "abstract", "text": [ "We will then highlight some epigenetic changes in glioblastomas, a malignant form of brain tumor, and potential application of epigenetic means for diagnosis, prognosis, and treatment of gliomas. " ], "offsets": [ [ 549, 745 ] ] } ]

[ { "id": "6602", "type": "Relation_Trigger", "text": [ "alterations in gene expression" ], "offsets": [ [ 44, 74 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d141.s0.e0" } ] }, { "id": "6603", "type": "Relation_Trigger", "text": [ "expression without changes" ], "offsets": [ [ 64, 90 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d141.s0.e1" } ] }, { "id": "6604", "type": "Diseases", "text": [ "gliomas" ], "offsets": [ [ 131, 138 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d141.s1.e0" } ] }, { "id": "6605", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 232, 238 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d141.s2.e0" } ] }, { "id": "6606", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 447, 452 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d141.s3.e0" } ] }, { "id": "6607", "type": "Relation_Trigger", "text": [ "regulate gene expression" ], "offsets": [ [ 421, 445 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d141.s3.e1" } ] }, { "id": "6608", "type": "Diseases", "text": [ "cancer" ], "offsets": [ [ 534, 540 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d141.s3.e2" } ] }, { "id": "6609", "type": "Diseases", "text": [ "gliomas" ], "offsets": [ [ 736, 743 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d141.s5.e0" } ] }, { "id": "6610", "type": "Diseases", "text": [ "glioblastomas" ], "offsets": [ [ 599, 612 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d141.s5.e1" } ] }, { "id": "6611", "type": "Diseases", "text": [ "brain tumor" ], "offsets": [ [ 634, 645 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d141.s5.e2" } ] } ]

[]

[]

[ { "id": "6612", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d141.s3.e0", "arg2_id": "miRNA-corp.d141.s3.e2", "normalized": [] } ]

[ { "id": "6614", "type": "title", "text": [ "Interpretation and applicability of microRNA data to the context of Alzheimer's and age-related diseases. " ], "offsets": [ [ 0, 107 ] ] }, { "id": "6615", "type": "abstract", "text": [ "Generated by the ribonuclease III Dicer, microRNAs (miRNAs) are predicted to regulate up to 90% of the genes in humans, suggesting that they may control every cellular processes in all cells and tissues of the human body! " ], "offsets": [ [ 108, 330 ] ] }, { "id": "6616", "type": "abstract", "text": [ "Likely to play a central role in health and disease, a dysfunctional miRNA-based regulation of gene expression may represent the main etiologic factor underlying age-related diseases affecting major organs, such as the brain. " ], "offsets": [ [ 331, 557 ] ] }, { "id": "6617", "type": "abstract", "text": [ "Here, we discuss some of the limitations associated to the interpretation and applicability of miRNA data, based on our recent study on the etiology of Alzheimer's disease (AD). " ], "offsets": [ [ 558, 736 ] ] }, { "id": "6618", "type": "abstract", "text": [ "Using transiently transfected murine neuronal N2a cells in culture, in parallel to a mouse model of AD, we were able to demonstrate a role for two miRNAs (miR-298 and miR-328) in the regulation of beta-amyloid (Abeta) precursor protein (APP)-converting enzyme (BACE) messenger RNA (mRNA) translation, thereby providing key insights into the molecular basis underlying BACE deregulation in AD. " ], "offsets": [ [ 737, 1130 ] ] }, { "id": "6619", "type": "abstract", "text": [ "However, whether miRNA data can be extrapolated and transposed to the human context of age-related diseases, such as AD, not only requires caution, but also warrants several considerations. " ], "offsets": [ [ 1131, 1323 ] ] } ]

[ { "id": "6620", "type": "Non-Specific_miRNAs", "text": [ "microRNA" ], "offsets": [ [ 36, 44 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d142.s0.e0" } ] }, { "id": "6621", "type": "Diseases", "text": [ "Alzheimer's" ], "offsets": [ [ 68, 79 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d142.s0.e1" } ] }, { "id": "6622", "type": "Non-Specific_miRNAs", "text": [ "microRNAs" ], "offsets": [ [ 149, 158 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d142.s1.e0" } ] }, { "id": "6623", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 160, 166 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d142.s1.e1" } ] }, { "id": "6624", "type": "Genes/Proteins", "text": [ "ribonuclease III Dicer" ], "offsets": [ [ 125, 147 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d142.s1.e2" } ] }, { "id": "6625", "type": "Relation_Trigger", "text": [ "regulate up" ], "offsets": [ [ 185, 196 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d142.s1.e3" } ] }, { "id": "6626", "type": "Species", "text": [ "humans" ], "offsets": [ [ 220, 226 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d142.s1.e4" } ] }, { "id": "6627", "type": "Species", "text": [ "human" ], "offsets": [ [ 318, 323 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d142.s1.e5" } ] }, { "id": "6628", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 400, 405 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d142.s2.e0" } ] }, { "id": "6629", "type": "Relation_Trigger", "text": [ "regulation of gene expression" ], "offsets": [ [ 412, 441 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d142.s2.e1" } ] }, { "id": "6630", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 653, 658 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d142.s3.e0" } ] }, { "id": "6631", "type": "Relation_Trigger", "text": [ "associated" ], "offsets": [ [ 599, 609 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d142.s3.e1" } ] }, { "id": "6632", "type": "Diseases", "text": [ "Alzheimer's disease" ], "offsets": [ [ 710, 729 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d142.s3.e2" } ] }, { "id": "6633", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 731, 733 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d142.s3.e3" } ] }, { "id": "6634", "type": "Genes/Proteins", "text": [ "APP" ], "offsets": [ [ 974, 977 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d142.s4.e0" } ] }, { "id": "6635", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 884, 890 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d142.s4.e1" } ] }, { "id": "6636", "type": "Genes/Proteins", "text": [ "beta-amyloid (Abeta) precursor protein (APP)-converting enzyme" ], "offsets": [ [ 934, 996 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d142.s4.e2" } ] }, { "id": "6637", "type": "Relation_Trigger", "text": [ "deregulation" ], "offsets": [ [ 1110, 1122 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d142.s4.e3" } ] }, { "id": "6638", "type": "Specific_miRNAs", "text": [ "miR-298" ], "offsets": [ [ 892, 899 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d142.s4.e4" } ] }, { "id": "6639", "type": "Specific_miRNAs", "text": [ "miR-328" ], "offsets": [ [ 904, 911 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d142.s4.e5" } ] }, { "id": "6640", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 837, 839 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d142.s4.e6" } ] }, { "id": "6641", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 1126, 1128 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d142.s4.e7" } ] }, { "id": "6642", "type": "Genes/Proteins", "text": [ "BACE" ], "offsets": [ [ 1105, 1109 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d142.s4.e8" } ] }, { "id": "6643", "type": "Genes/Proteins", "text": [ "BACE" ], "offsets": [ [ 998, 1002 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d142.s4.e9" } ] }, { "id": "6644", "type": "Relation_Trigger", "text": [ "regulation of beta-amyloid (Abeta) precursor protein (APP)-converting enzyme (BACE) messenger RNA (mRNA) translation" ], "offsets": [ [ 920, 1036 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d142.s4.e10" } ] }, { "id": "6645", "type": "Species", "text": [ "mouse" ], "offsets": [ [ 822, 827 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d142.s4.e11" } ] }, { "id": "6646", "type": "Species", "text": [ "murine" ], "offsets": [ [ 767, 773 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d142.s4.e12" } ] }, { "id": "6647", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 1248, 1250 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d142.s5.e0" } ] }, { "id": "6648", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1148, 1153 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d142.s5.e1" } ] }, { "id": "6649", "type": "Species", "text": [ "human" ], "offsets": [ [ 1201, 1206 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d142.s5.e2" } ] } ]

[]

[]

[ { "id": "6650", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d142.s0.e0", "arg2_id": "miRNA-corp.d142.s0.e1", "normalized": [] }, { "id": "6651", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d142.s1.e0", "arg2_id": "miRNA-corp.d142.s1.e2", "normalized": [] }, { "id": "6652", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d142.s1.e1", "arg2_id": "miRNA-corp.d142.s1.e2", "normalized": [] }, { "id": "6653", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d142.s3.e0", "arg2_id": "miRNA-corp.d142.s3.e2", "normalized": [] }, { "id": "6654", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d142.s3.e0", "arg2_id": "miRNA-corp.d142.s3.e3", "normalized": [] }, { "id": "6655", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d142.s4.e4", "arg2_id": "miRNA-corp.d142.s4.e0", "normalized": [] }, { "id": "6656", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d142.s4.e4", "arg2_id": "miRNA-corp.d142.s4.e6", "normalized": [] }, { "id": "6657", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d142.s4.e4", "arg2_id": "miRNA-corp.d142.s4.e7", "normalized": [] }, { "id": "6658", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d142.s4.e4", "arg2_id": "miRNA-corp.d142.s4.e8", "normalized": [] }, { "id": "6659", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d142.s4.e4", "arg2_id": "miRNA-corp.d142.s4.e9", "normalized": [] }, { "id": "6660", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d142.s4.e4", "arg2_id": "miRNA-corp.d142.s4.e2", "normalized": [] }, { "id": "6661", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d142.s4.e5", "arg2_id": "miRNA-corp.d142.s4.e0", "normalized": [] }, { "id": "6662", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d142.s4.e5", "arg2_id": "miRNA-corp.d142.s4.e6", "normalized": [] }, { "id": "6663", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d142.s4.e5", "arg2_id": "miRNA-corp.d142.s4.e7", "normalized": [] }, { "id": "6664", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d142.s4.e5", "arg2_id": "miRNA-corp.d142.s4.e8", "normalized": [] }, { "id": "6665", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d142.s4.e5", "arg2_id": "miRNA-corp.d142.s4.e9", "normalized": [] }, { "id": "6666", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d142.s4.e5", "arg2_id": "miRNA-corp.d142.s4.e2", "normalized": [] }, { "id": "6667", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d142.s4.e1", "arg2_id": "miRNA-corp.d142.s4.e0", "normalized": [] }, { "id": "6668", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d142.s4.e1", "arg2_id": "miRNA-corp.d142.s4.e6", "normalized": [] }, { "id": "6669", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d142.s4.e1", "arg2_id": "miRNA-corp.d142.s4.e7", "normalized": [] }, { "id": "6670", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d142.s4.e1", "arg2_id": "miRNA-corp.d142.s4.e8", "normalized": [] }, { "id": "6671", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d142.s4.e1", "arg2_id": "miRNA-corp.d142.s4.e9", "normalized": [] }, { "id": "6672", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d142.s4.e1", "arg2_id": "miRNA-corp.d142.s4.e2", "normalized": [] }, { "id": "6673", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d142.s5.e1", "arg2_id": "miRNA-corp.d142.s5.e0", "normalized": [] } ]

[ { "id": "6675", "type": "title", "text": [ "Levels of protein expression of endothelial NO synthase (eNOS), caveolin-1, and calmodulin were assessed in carotid arteries using Western analysis. " ], "offsets": [ [ 0, 149 ] ] }, { "id": "6676", "type": "abstract", "text": [ "NO production and endothelium-dependent contraction in response to the NOS inhibitor NG-nitro-L-arginine (L-NNA; 100 microM) was enhanced by 50 to 100% in carotid arteries from rats treated with daidzein or 17beta-estradiol. " ], "offsets": [ [ 150, 375 ] ] }, { "id": "6677", "type": "abstract", "text": [ "Acetylcholine-induced relaxation was selectively enhanced in carotid arteries from rats treated with daidzein. " ], "offsets": [ [ 376, 487 ] ] }, { "id": "6678", "type": "abstract", "text": [ "The use of estrogen for protection against vascular dysfunction is limited due to its effects on the reproductive system, particularly in males. " ], "offsets": [ [ 488, 633 ] ] }, { "id": "6679", "type": "abstract", "text": [ "Male rats were administered vehicle, 17beta-estradiol (0.1 mg/kg s.c.), or daidzein (0.2 mg/kg s.c.) daily for 7 days. " ], "offsets": [ [ 634, 753 ] ] }, { "id": "6680", "type": "abstract", "text": [ "Similarly, constrictor responses of the basilar artery to L-NNA in vivo were selectively augmented by approximately 100% by 17beta-estradiol treatment and tended to be approximately 50% greater in daidzein-treated rats. " ], "offsets": [ [ 754, 974 ] ] }, { "id": "6681", "type": "abstract", "text": [ "Effect of short-term phytoestrogen treatment in male rats on nitric oxide-mediated responses of carotid and cerebral arteries: comparison with 17beta-estradiol. " ], "offsets": [ [ 975, 1137 ] ] }, { "id": "6682", "type": "abstract", "text": [ "These data suggest that short-term administration of daidzein or 17beta-estradiol modulates cerebral artery reactivity in males by enhancing synthesis and release of endothelium-derived NO. Isoflavone therapy may therefore be a feasible approach to protect against cerebrovascular disease and stroke. " ], "offsets": [ [ 1138, 1441 ] ] }, { "id": "6683", "type": "abstract", "text": [ "Expression of caveolin-1 was decreased, and calmodulin was increased, in vessels from daidzein- or 17beta-estradiol-treated rats. " ], "offsets": [ [ 1442, 1572 ] ] }, { "id": "6684", "type": "abstract", "text": [ "eNOS expression was unaffected by the treatments. " ], "offsets": [ [ 1573, 1623 ] ] } ]

[ { "id": "6685", "type": "Genes/Proteins", "text": [ "caveolin-1" ], "offsets": [ [ 64, 74 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d143.s0.e0" } ] }, { "id": "6686", "type": "Genes/Proteins", "text": [ "calmodulin" ], "offsets": [ [ 80, 90 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d143.s0.e1" } ] }, { "id": "6687", "type": "Genes/Proteins", "text": [ "eNOS" ], "offsets": [ [ 57, 61 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d143.s0.e2" } ] }, { "id": "6688", "type": "Genes/Proteins", "text": [ "endothelial NO synthase" ], "offsets": [ [ 32, 55 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d143.s0.e3" } ] }, { "id": "6689", "type": "Relation_Trigger", "text": [ "inhibitor" ], "offsets": [ [ 225, 234 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d143.s2.e0" } ] }, { "id": "6690", "type": "Species", "text": [ "rats" ], "offsets": [ [ 327, 331 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d143.s2.e1" } ] }, { "id": "6691", "type": "Species", "text": [ "rats" ], "offsets": [ [ 459, 463 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d143.s3.e0" } ] }, { "id": "6692", "type": "Diseases", "text": [ "vascular dysfunction" ], "offsets": [ [ 531, 551 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d143.s4.e0" } ] }, { "id": "6693", "type": "Species", "text": [ "rats" ], "offsets": [ [ 639, 643 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d143.s6.e0" } ] }, { "id": "6694", "type": "Species", "text": [ "rats" ], "offsets": [ [ 968, 972 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d143.s8.e0" } ] }, { "id": "6695", "type": "Species", "text": [ "rats" ], "offsets": [ [ 1028, 1032 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d143.s9.e0" } ] }, { "id": "6696", "type": "Relation_Trigger", "text": [ "modulates" ], "offsets": [ [ 1220, 1229 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d143.s10.e0" } ] }, { "id": "6697", "type": "Diseases", "text": [ "cerebrovascular disease" ], "offsets": [ [ 1403, 1426 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d143.s10.e1" } ] }, { "id": "6698", "type": "Diseases", "text": [ "stroke" ], "offsets": [ [ 1431, 1437 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d143.s10.e2" } ] }, { "id": "6699", "type": "Genes/Proteins", "text": [ "caveolin-1" ], "offsets": [ [ 1456, 1466 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d143.s11.e0" } ] }, { "id": "6700", "type": "Genes/Proteins", "text": [ "calmodulin" ], "offsets": [ [ 1486, 1496 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d143.s11.e1" } ] }, { "id": "6701", "type": "Relation_Trigger", "text": [ "Expression of caveolin-1 was decreased" ], "offsets": [ [ 1442, 1480 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d143.s11.e2" } ] }, { "id": "6702", "type": "Species", "text": [ "rats" ], "offsets": [ [ 1566, 1570 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d143.s11.e3" } ] }, { "id": "6703", "type": "Genes/Proteins", "text": [ "eNOS" ], "offsets": [ [ 1573, 1577 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d143.s12.e0" } ] } ]

[]

[]

[]

[ { "id": "6705", "type": "title", "text": [ "Human brains retain discrete populations of micro RNA (miRNA) species that support homeostatic brain gene expression functions; however, specific miRNA abundance is significantly altered in neurological disorders such as Alzheimer disease (AD) when compared with age-matched controls. " ], "offsets": [ [ 0, 285 ] ] }, { "id": "6706", "type": "abstract", "text": [ "An NF-kappaB-sensitive micro RNA-146a-mediated inflammatory circuit in Alzheimer disease and in stressed human brain cells. " ], "offsets": [ [ 286, 411 ] ] }, { "id": "6707", "type": "abstract", "text": [ "Up-regulation of miRNA-146a coupled to down-regulation of CFH was observed in AD brain and in interleukin-1beta, Abeta42, and/or oxidatively stressed human neural (HN) cells in primary culture. " ], "offsets": [ [ 412, 606 ] ] }, { "id": "6708", "type": "abstract", "text": [ "Here we provide evidence in AD brains of a specific up-regulation of an NF-kappaB-sensitive miRNA-146a highly complementary to the 3'-untranslated region of complement factor H (CFH), an important repressor of the inflammatory response of the brain. " ], "offsets": [ [ 607, 857 ] ] }, { "id": "6709", "type": "abstract", "text": [ "Treatment of stressed HN cells with the NF-kappaB inhibitor pyrollidine dithiocarbamate or the resveratrol analog CAY10512 abrogated this response. " ], "offsets": [ [ 858, 1006 ] ] }, { "id": "6710", "type": "abstract", "text": [ "Transfection of HN cells using an NF-kappaB-containing pre-miRNA-146a promoter-luciferase reporter construct in stressed HN cells showed significant up-regulation of luciferase activity that paralleled decreases in CFH gene expression. " ], "offsets": [ [ 1007, 1243 ] ] }, { "id": "6711", "type": "abstract", "text": [ "Incubation of an antisense oligonucleotide to miRNA-146a (anti-miRNA-146a; AM-146a) was found to restore CFH expression levels. " ], "offsets": [ [ 1244, 1372 ] ] }, { "id": "6712", "type": "abstract", "text": [ "These data indicate that NF-kappaB-sensitive miRNA-146a-mediated modulation of CFH gene expression may in part regulate an inflammatory response in AD brain and in stressed HN cell models of AD and illustrate the potential for anti-miRNAs as an effective therapeutic strategy against pathogenic inflammatory signaling. " ], "offsets": [ [ 1373, 1694 ] ] } ]

[ { "id": "6713", "type": "Diseases", "text": [ "Alzheimer disease" ], "offsets": [ [ 221, 238 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d144.s0.e0" } ] }, { "id": "6714", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 240, 242 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d144.s0.e1" } ] }, { "id": "6715", "type": "Non-Specific_miRNAs", "text": [ "micro RNA" ], "offsets": [ [ 44, 53 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d144.s0.e2" } ] }, { "id": "6716", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 55, 60 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d144.s0.e3" } ] }, { "id": "6717", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 146, 151 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d144.s0.e4" } ] }, { "id": "6718", "type": "Relation_Trigger", "text": [ "significantly altered" ], "offsets": [ [ 165, 186 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d144.s0.e5" } ] }, { "id": "6719", "type": "Diseases", "text": [ "neurological disorders" ], "offsets": [ [ 190, 212 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d144.s0.e6" } ] }, { "id": "6720", "type": "Species", "text": [ "Human" ], "offsets": [ [ 0, 5 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d144.s0.e7" } ] }, { "id": "6721", "type": "Diseases", "text": [ "Alzheimer disease" ], "offsets": [ [ 357, 374 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d144.s1.e0" } ] }, { "id": "6722", "type": "Specific_miRNAs", "text": [ "micro RNA-146a" ], "offsets": [ [ 309, 323 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d144.s1.e1" } ] }, { "id": "6723", "type": "Species", "text": [ "human" ], "offsets": [ [ 391, 396 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d144.s1.e2" } ] }, { "id": "6724", "type": "Specific_miRNAs", "text": [ "miRNA-146a" ], "offsets": [ [ 429, 439 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d144.s2.e0" } ] }, { "id": "6725", "type": "Genes/Proteins", "text": [ "CFH" ], "offsets": [ [ 470, 473 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d144.s2.e1" } ] }, { "id": "6726", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 490, 492 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d144.s2.e2" } ] }, { "id": "6727", "type": "Genes/Proteins", "text": [ "interleukin-1beta" ], "offsets": [ [ 506, 523 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d144.s2.e3" } ] }, { "id": "6728", "type": "Relation_Trigger", "text": [ "Up-regulation" ], "offsets": [ [ 412, 425 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d144.s2.e4" } ] }, { "id": "6729", "type": "Relation_Trigger", "text": [ "down-regulation" ], "offsets": [ [ 451, 466 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d144.s2.e5" } ] }, { "id": "6730", "type": "Genes/Proteins", "text": [ "Abeta42" ], "offsets": [ [ 525, 532 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d144.s2.e6" } ] }, { "id": "6731", "type": "Species", "text": [ "human" ], "offsets": [ [ 562, 567 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d144.s2.e7" } ] }, { "id": "6732", "type": "Specific_miRNAs", "text": [ "miRNA-146a" ], "offsets": [ [ 699, 709 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d144.s3.e0" } ] }, { "id": "6733", "type": "Genes/Proteins", "text": [ "complement factor H " ], "offsets": [ [ 764, 784 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d144.s3.e1" } ] }, { "id": "6734", "type": "Genes/Proteins", "text": [ "CFH" ], "offsets": [ [ 785, 788 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d144.s3.e2" } ] }, { "id": "6735", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 635, 637 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d144.s3.e3" } ] }, { "id": "6736", "type": "Relation_Trigger", "text": [ "up-regulation" ], "offsets": [ [ 659, 672 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d144.s3.e4" } ] }, { "id": "6737", "type": "Relation_Trigger", "text": [ "highly complementary to the 3'-untranslated region" ], "offsets": [ [ 710, 760 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d144.s3.e5" } ] }, { "id": "6738", "type": "Relation_Trigger", "text": [ "repressor" ], "offsets": [ [ 804, 813 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d144.s3.e6" } ] }, { "id": "6739", "type": "Relation_Trigger", "text": [ "inhibitor" ], "offsets": [ [ 908, 917 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d144.s4.e0" } ] }, { "id": "6740", "type": "Genes/Proteins", "text": [ "CFH" ], "offsets": [ [ 1222, 1225 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d144.s5.e0" } ] }, { "id": "6741", "type": "Specific_miRNAs", "text": [ "miRNA-146a" ], "offsets": [ [ 1066, 1076 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d144.s5.e1" } ] }, { "id": "6742", "type": "Relation_Trigger", "text": [ "decreases in CFH gene expression" ], "offsets": [ [ 1209, 1241 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d144.s5.e2" } ] }, { "id": "6743", "type": "Relation_Trigger", "text": [ "up-regulation" ], "offsets": [ [ 1156, 1169 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d144.s5.e3" } ] }, { "id": "6744", "type": "Genes/Proteins", "text": [ "CFH" ], "offsets": [ [ 1349, 1352 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d144.s6.e0" } ] }, { "id": "6745", "type": "Genes/Proteins", "text": [ "CFH" ], "offsets": [ [ 1452, 1455 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d144.s7.e0" } ] }, { "id": "6746", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 1564, 1566 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d144.s7.e1" } ] }, { "id": "6747", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 1521, 1523 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d144.s7.e2" } ] }, { "id": "6748", "type": "Specific_miRNAs", "text": [ "miRNA-146a" ], "offsets": [ [ 1418, 1428 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d144.s7.e3" } ] }, { "id": "6749", "type": "Relation_Trigger", "text": [ "regulate" ], "offsets": [ [ 1484, 1492 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d144.s7.e4" } ] }, { "id": "6750", "type": "Relation_Trigger", "text": [ "modulation of CFH gene expression" ], "offsets": [ [ 1438, 1471 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d144.s7.e5" } ] } ]

[]

[]

[ { "id": "6751", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d144.s0.e2", "arg2_id": "miRNA-corp.d144.s0.e0", "normalized": [] }, { "id": "6752", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d144.s0.e2", "arg2_id": "miRNA-corp.d144.s0.e1", "normalized": [] }, { "id": "6753", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d144.s0.e2", "arg2_id": "miRNA-corp.d144.s0.e6", "normalized": [] }, { "id": "6754", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d144.s0.e3", "arg2_id": "miRNA-corp.d144.s0.e0", "normalized": [] }, { "id": "6755", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d144.s0.e3", "arg2_id": "miRNA-corp.d144.s0.e1", "normalized": [] }, { "id": "6756", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d144.s0.e3", "arg2_id": "miRNA-corp.d144.s0.e6", "normalized": [] }, { "id": "6757", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d144.s0.e4", "arg2_id": "miRNA-corp.d144.s0.e0", "normalized": [] }, { "id": "6758", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d144.s0.e4", "arg2_id": "miRNA-corp.d144.s0.e1", "normalized": [] }, { "id": "6759", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d144.s0.e4", "arg2_id": "miRNA-corp.d144.s0.e6", "normalized": [] }, { "id": "6760", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d144.s1.e1", "arg2_id": "miRNA-corp.d144.s1.e0", "normalized": [] }, { "id": "6761", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d144.s2.e0", "arg2_id": "miRNA-corp.d144.s2.e3", "normalized": [] }, { "id": "6762", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d144.s2.e0", "arg2_id": "miRNA-corp.d144.s2.e6", "normalized": [] }, { "id": "6763", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d144.s2.e0", "arg2_id": "miRNA-corp.d144.s2.e1", "normalized": [] }, { "id": "6764", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d144.s2.e0", "arg2_id": "miRNA-corp.d144.s2.e2", "normalized": [] }, { "id": "6765", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d144.s3.e0", "arg2_id": "miRNA-corp.d144.s3.e1", "normalized": [] }, { "id": "6766", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d144.s3.e0", "arg2_id": "miRNA-corp.d144.s3.e2", "normalized": [] }, { "id": "6767", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d144.s3.e0", "arg2_id": "miRNA-corp.d144.s3.e3", "normalized": [] }, { "id": "6768", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d144.s5.e1", "arg2_id": "miRNA-corp.d144.s5.e0", "normalized": [] }, { "id": "6769", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d144.s7.e3", "arg2_id": "miRNA-corp.d144.s7.e0", "normalized": [] }, { "id": "6770", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d144.s7.e3", "arg2_id": "miRNA-corp.d144.s7.e1", "normalized": [] }, { "id": "6771", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d144.s7.e3", "arg2_id": "miRNA-corp.d144.s7.e2", "normalized": [] } ]

[ { "id": "6773", "type": "title", "text": [ "Meanwhile, 3NP rats showed dynamic changes in the miRNA profiles during disease development and a few miRNAs with altered expression. " ], "offsets": [ [ 0, 134 ] ] }, { "id": "6774", "type": "abstract", "text": [ "In 10-week-old R6/2 mice, downregulation was dominant in the miRNA expressions and the level of Drosha decreased concomitantly. " ], "offsets": [ [ 135, 263 ] ] }, { "id": "6775", "type": "abstract", "text": [ "Nine miRNAs (miR-22, miR-29c, miR-128, miR-132, miR-138, miR-218, miR-222, miR-344, and miR-674*) were commonly down-regulated in both the 12-month-old YAC128 and 10-week-old R6/2 mice. " ], "offsets": [ [ 264, 450 ] ] }, { "id": "6776", "type": "abstract", "text": [ "Concomitantly, the expressions of Drosha-DGCR8, Exportin-5, and Dcp1 were increased at 5months, and the expression of Dicer was decreased at 12 months. " ], "offsets": [ [ 451, 603 ] ] }, { "id": "6777", "type": "abstract", "text": [ "YAC128 mice showed upregulation-dominant miRNA expressions at 5 months and downregulation-dominant expressions at 12 months. " ], "offsets": [ [ 604, 729 ] ] }, { "id": "6778", "type": "abstract", "text": [ "After characterizing the phenotypes by behavioral tests and histological analyses, we profiled striatal miRNAs using a miRNA microarray and we measured the key molecules involved in miRNA biogenesis and function. " ], "offsets": [ [ 730, 943 ] ] }, { "id": "6779", "type": "abstract", "text": [ "Here, we analyzed the miRNA expression and miRNA regulators in two transgenic models of HD, YAC128 and R6/2 mice, and in a 3-nitropropionic acid (3NP)-induced striatal degeneration rat model. " ], "offsets": [ [ 944, 1136 ] ] }, { "id": "6780", "type": "abstract", "text": [ "MicroRNAs (miRNAs) are short RNA molecules regulating gene expression, and are implicated in a variety of diseases including HD. However, the profiles and regulation of miRNAs in HD are not fully understood. " ], "offsets": [ [ 1137, 1345 ] ] }, { "id": "6781", "type": "abstract", "text": [ "Huntington's disease (HD) is a genetic neurodegenerative disease caused by abnormal CAG expansion. " ], "offsets": [ [ 1346, 1445 ] ] }, { "id": "6782", "type": "abstract", "text": [ "Altered microRNA regulation in Huntington's disease models. " ], "offsets": [ [ 1446, 1507 ] ] }, { "id": "6783", "type": "abstract", "text": [ "This information should aid in future studies on therapeutic application of miRNAs in HD. " ], "offsets": [ [ 1508, 1600 ] ] }, { "id": "6784", "type": "abstract", "text": [ "Our results show that transgenic HD mice have abnormal miRNA biogenesis. " ], "offsets": [ [ 1601, 1674 ] ] } ]

[ { "id": "6785", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 50, 55 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s0.e0" } ] }, { "id": "6786", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 102, 108 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s0.e1" } ] }, { "id": "6787", "type": "Relation_Trigger", "text": [ "altered expression" ], "offsets": [ [ 114, 132 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s0.e2" } ] }, { "id": "6788", "type": "Species", "text": [ "rats" ], "offsets": [ [ 15, 19 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s0.e3" } ] }, { "id": "6789", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 196, 201 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s1.e0" } ] }, { "id": "6790", "type": "Genes/Proteins", "text": [ "Drosha" ], "offsets": [ [ 231, 237 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s1.e1" } ] }, { "id": "6791", "type": "Relation_Trigger", "text": [ "downregulation" ], "offsets": [ [ 161, 175 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s1.e2" } ] }, { "id": "6792", "type": "Relation_Trigger", "text": [ "level of Drosha decreased" ], "offsets": [ [ 222, 247 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s1.e3" } ] }, { "id": "6793", "type": "Species", "text": [ "mice" ], "offsets": [ [ 155, 159 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s1.e4" } ] }, { "id": "6794", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 269, 275 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s2.e0" } ] }, { "id": "6795", "type": "Specific_miRNAs", "text": [ "miR-22" ], "offsets": [ [ 277, 283 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s2.e1" } ] }, { "id": "6796", "type": "Specific_miRNAs", "text": [ "miR-29c" ], "offsets": [ [ 285, 292 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s2.e2" } ] }, { "id": "6797", "type": "Specific_miRNAs", "text": [ "miR-128" ], "offsets": [ [ 294, 301 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s2.e3" } ] }, { "id": "6798", "type": "Specific_miRNAs", "text": [ "miR-132" ], "offsets": [ [ 303, 310 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s2.e4" } ] }, { "id": "6799", "type": "Specific_miRNAs", "text": [ "miR-138" ], "offsets": [ [ 312, 319 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s2.e5" } ] }, { "id": "6800", "type": "Specific_miRNAs", "text": [ "miR-218" ], "offsets": [ [ 321, 328 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s2.e6" } ] }, { "id": "6801", "type": "Specific_miRNAs", "text": [ "miR-222" ], "offsets": [ [ 330, 337 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s2.e7" } ] }, { "id": "6802", "type": "Specific_miRNAs", "text": [ "miR-344" ], "offsets": [ [ 339, 346 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s2.e8" } ] }, { "id": "6803", "type": "Specific_miRNAs", "text": [ "miR-674" ], "offsets": [ [ 352, 359 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s2.e9" } ] }, { "id": "6804", "type": "Relation_Trigger", "text": [ "down-regulated" ], "offsets": [ [ 376, 390 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s2.e10" } ] }, { "id": "6805", "type": "Species", "text": [ "mice" ], "offsets": [ [ 444, 448 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s2.e11" } ] }, { "id": "6806", "type": "Species", "text": [ "mice" ], "offsets": [ [ 444, 448 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s2.e12" } ] }, { "id": "6807", "type": "Genes/Proteins", "text": [ "Exportin-5" ], "offsets": [ [ 499, 509 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s3.e0" } ] }, { "id": "6808", "type": "Genes/Proteins", "text": [ "Dicer" ], "offsets": [ [ 569, 574 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s3.e1" } ] }, { "id": "6809", "type": "Relation_Trigger", "text": [ "expressions of Drosha-DGCR8, Exportin-5, and Dcp1 were increased" ], "offsets": [ [ 470, 534 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s3.e2" } ] }, { "id": "6810", "type": "Relation_Trigger", "text": [ "expression of Dicer was decreased" ], "offsets": [ [ 555, 588 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s3.e3" } ] }, { "id": "6811", "type": "Genes/Proteins", "text": [ "Drosha" ], "offsets": [ [ 485, 491 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s3.e4" } ] }, { "id": "6812", "type": "Genes/Proteins", "text": [ "DGCR8" ], "offsets": [ [ 492, 497 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s3.e5" } ] }, { "id": "6813", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 645, 650 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s4.e0" } ] }, { "id": "6814", "type": "Species", "text": [ "mice" ], "offsets": [ [ 611, 615 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s4.e1" } ] }, { "id": "6815", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 834, 840 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s5.e0" } ] }, { "id": "6816", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 849, 854 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s5.e1" } ] }, { "id": "6817", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 912, 917 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s5.e2" } ] }, { "id": "6818", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 966, 971 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s6.e0" } ] }, { "id": "6819", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 987, 992 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s6.e1" } ] }, { "id": "6820", "type": "Diseases", "text": [ "HD" ], "offsets": [ [ 1032, 1034 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s6.e2" } ] }, { "id": "6821", "type": "Relation_Trigger", "text": [ "regulators" ], "offsets": [ [ 993, 1003 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s6.e3" } ] }, { "id": "6822", "type": "Species", "text": [ "mice" ], "offsets": [ [ 1052, 1056 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s6.e4" } ] }, { "id": "6823", "type": "Species", "text": [ "rat" ], "offsets": [ [ 1125, 1128 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s6.e5" } ] }, { "id": "6824", "type": "Non-Specific_miRNAs", "text": [ "MicroRNAs" ], "offsets": [ [ 1137, 1146 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s7.e0" } ] }, { "id": "6825", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1148, 1154 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s7.e1" } ] }, { "id": "6826", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1306, 1312 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s7.e2" } ] }, { "id": "6827", "type": "Diseases", "text": [ "HD" ], "offsets": [ [ 1262, 1264 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s7.e3" } ] }, { "id": "6828", "type": "Diseases", "text": [ "HD" ], "offsets": [ [ 1316, 1318 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s7.e4" } ] }, { "id": "6829", "type": "Relation_Trigger", "text": [ "regulating gene expression" ], "offsets": [ [ 1180, 1206 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s7.e5" } ] }, { "id": "6830", "type": "Relation_Trigger", "text": [ "regulation" ], "offsets": [ [ 1292, 1302 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s7.e6" } ] }, { "id": "6831", "type": "Diseases", "text": [ "Huntington's disease" ], "offsets": [ [ 1346, 1366 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s8.e0" } ] }, { "id": "6832", "type": "Diseases", "text": [ "HD" ], "offsets": [ [ 1368, 1370 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s8.e1" } ] }, { "id": "6833", "type": "Diseases", "text": [ "neurodegenerative disease" ], "offsets": [ [ 1385, 1410 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s8.e2" } ] }, { "id": "6834", "type": "Non-Specific_miRNAs", "text": [ "microRNA" ], "offsets": [ [ 1454, 1462 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s9.e0" } ] }, { "id": "6835", "type": "Diseases", "text": [ "Huntington's disease" ], "offsets": [ [ 1477, 1497 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s9.e1" } ] }, { "id": "6836", "type": "Relation_Trigger", "text": [ "Altered microRNA regulation" ], "offsets": [ [ 1446, 1473 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s9.e2" } ] }, { "id": "6837", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1584, 1590 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s10.e0" } ] }, { "id": "6838", "type": "Diseases", "text": [ "HD" ], "offsets": [ [ 1594, 1596 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s10.e1" } ] }, { "id": "6839", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1656, 1661 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s11.e0" } ] }, { "id": "6840", "type": "Diseases", "text": [ "HD" ], "offsets": [ [ 1634, 1636 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s11.e1" } ] }, { "id": "6841", "type": "Species", "text": [ "mice" ], "offsets": [ [ 1637, 1641 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d145.s11.e2" } ] } ]

[]

[]

[ { "id": "6842", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d145.s1.e0", "arg2_id": "miRNA-corp.d145.s1.e1", "normalized": [] }, { "id": "6843", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d145.s6.e0", "arg2_id": "miRNA-corp.d145.s6.e2", "normalized": [] }, { "id": "6844", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d145.s6.e1", "arg2_id": "miRNA-corp.d145.s6.e2", "normalized": [] }, { "id": "6845", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d145.s7.e0", "arg2_id": "miRNA-corp.d145.s7.e3", "normalized": [] }, { "id": "6846", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d145.s7.e0", "arg2_id": "miRNA-corp.d145.s7.e4", "normalized": [] }, { "id": "6847", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d145.s7.e1", "arg2_id": "miRNA-corp.d145.s7.e3", "normalized": [] }, { "id": "6848", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d145.s7.e1", "arg2_id": "miRNA-corp.d145.s7.e4", "normalized": [] }, { "id": "6849", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d145.s7.e2", "arg2_id": "miRNA-corp.d145.s7.e3", "normalized": [] }, { "id": "6850", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d145.s7.e2", "arg2_id": "miRNA-corp.d145.s7.e4", "normalized": [] }, { "id": "6851", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d145.s9.e0", "arg2_id": "miRNA-corp.d145.s9.e1", "normalized": [] }, { "id": "6852", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d145.s10.e0", "arg2_id": "miRNA-corp.d145.s10.e1", "normalized": [] }, { "id": "6853", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d145.s11.e0", "arg2_id": "miRNA-corp.d145.s11.e1", "normalized": [] } ]

[ { "id": "6855", "type": "title", "text": [ "The prevalence of neurodegenerative disorders is rising steadily as human life expectancy increases. " ], "offsets": [ [ 0, 101 ] ] }, { "id": "6856", "type": "abstract", "text": [ "However, limited knowledge of the molecular basis of disease pathogenesis is a major hurdle in the identification of drug targets and development of therapeutic strategies for these largely incurable disorders. " ], "offsets": [ [ 102, 313 ] ] }, { "id": "6857", "type": "abstract", "text": [ "MicroRNAs: novel therapeutic targets in neurodegenerative diseases. " ], "offsets": [ [ 314, 383 ] ] }, { "id": "6858", "type": "abstract", "text": [ "Our bioinformatic analysis suggests novel miRNA-target interactions that could potentially influence neurodegeneration. " ], "offsets": [ [ 384, 504 ] ] }, { "id": "6859", "type": "abstract", "text": [ "The recent development of molecules that alter miRNA expression promises valuable tools that will enhance the therapeutic potential of miRNAs. " ], "offsets": [ [ 505, 650 ] ] }, { "id": "6860", "type": "abstract", "text": [ "Recently, differential expression of endogenous regulatory small RNAs, known as 'microRNAs' (miRNAs), in patients of Alzheimer's disease, Parkinson's disease and models of ataxia suggest that they might have key regulatory roles in neurodegeneration. " ], "offsets": [ [ 651, 902 ] ] }, { "id": "6861", "type": "abstract", "text": [ "miRNAs that can target known mediators of neurodegeneration offer potential therapeutic targets. " ], "offsets": [ [ 903, 1000 ] ] } ]

[ { "id": "6862", "type": "Diseases", "text": [ "neurodegenerative disorders" ], "offsets": [ [ 18, 45 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d146.s0.e0" } ] }, { "id": "6863", "type": "Species", "text": [ "human" ], "offsets": [ [ 68, 73 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d146.s0.e1" } ] }, { "id": "6864", "type": "Relation_Trigger", "text": [ "targets" ], "offsets": [ [ 224, 231 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d146.s1.e0" } ] }, { "id": "6865", "type": "Non-Specific_miRNAs", "text": [ "MicroRNAs" ], "offsets": [ [ 314, 323 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d146.s2.e0" } ] }, { "id": "6866", "type": "Relation_Trigger", "text": [ "therapeutic targets" ], "offsets": [ [ 331, 350 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d146.s2.e1" } ] }, { "id": "6867", "type": "Diseases", "text": [ "neurodegenerative diseases" ], "offsets": [ [ 354, 380 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d146.s2.e2" } ] }, { "id": "6868", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 426, 431 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d146.s3.e0" } ] }, { "id": "6869", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 552, 557 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d146.s4.e0" } ] }, { "id": "6870", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 640, 646 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d146.s4.e1" } ] }, { "id": "6871", "type": "Relation_Trigger", "text": [ "alter miRNA expression" ], "offsets": [ [ 546, 568 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d146.s4.e2" } ] }, { "id": "6872", "type": "Non-Specific_miRNAs", "text": [ "microRNAs" ], "offsets": [ [ 732, 741 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d146.s5.e0" } ] }, { "id": "6873", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 744, 750 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d146.s5.e1" } ] }, { "id": "6874", "type": "Diseases", "text": [ "Alzheimer's disease" ], "offsets": [ [ 768, 787 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d146.s5.e2" } ] }, { "id": "6875", "type": "Diseases", "text": [ "Parkinson's disease" ], "offsets": [ [ 789, 808 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d146.s5.e3" } ] }, { "id": "6876", "type": "Relation_Trigger", "text": [ "regulatory" ], "offsets": [ [ 699, 709 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d146.s5.e4" } ] }, { "id": "6877", "type": "Relation_Trigger", "text": [ "regulatory" ], "offsets": [ [ 863, 873 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d146.s5.e5" } ] }, { "id": "6878", "type": "Relation_Trigger", "text": [ "differential expression" ], "offsets": [ [ 661, 684 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d146.s5.e6" } ] }, { "id": "6879", "type": "Diseases", "text": [ "ataxia" ], "offsets": [ [ 823, 829 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d146.s5.e7" } ] }, { "id": "6880", "type": "Species", "text": [ "patients" ], "offsets": [ [ 756, 764 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d146.s5.e8" } ] }, { "id": "6881", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 903, 909 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d146.s6.e0" } ] }, { "id": "6882", "type": "Relation_Trigger", "text": [ "target" ], "offsets": [ [ 919, 925 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d146.s6.e1" } ] }, { "id": "6883", "type": "Relation_Trigger", "text": [ "therapeutic targets" ], "offsets": [ [ 979, 998 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d146.s6.e2" } ] } ]

[]

[]

[ { "id": "6884", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d146.s2.e0", "arg2_id": "miRNA-corp.d146.s2.e2", "normalized": [] }, { "id": "6885", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d146.s5.e0", "arg2_id": "miRNA-corp.d146.s5.e7", "normalized": [] }, { "id": "6886", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d146.s5.e0", "arg2_id": "miRNA-corp.d146.s5.e2", "normalized": [] }, { "id": "6887", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d146.s5.e0", "arg2_id": "miRNA-corp.d146.s5.e3", "normalized": [] }, { "id": "6888", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d146.s5.e1", "arg2_id": "miRNA-corp.d146.s5.e7", "normalized": [] }, { "id": "6889", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d146.s5.e1", "arg2_id": "miRNA-corp.d146.s5.e2", "normalized": [] }, { "id": "6890", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d146.s5.e1", "arg2_id": "miRNA-corp.d146.s5.e3", "normalized": [] } ]

[ { "id": "6892", "type": "title", "text": [ "To our knowledge, this is the first report of miRNA profiles in A. cantonensis, which may represent a new platform for studying regulation of genes and their networks in A. cantonensis. " ], "offsets": [ [ 0, 188 ] ] }, { "id": "6893", "type": "abstract", "text": [ "Nucleotide bias analysis showed that uracil was the prominent nucleotide, particularly at positions of 1, 10, 14, 17 and 22, approximately at the beginning, middle and the end of the conserved miRNAs. " ], "offsets": [ [ 189, 390 ] ] }, { "id": "6894", "type": "abstract", "text": [ "No new miRNA sequence was found. " ], "offsets": [ [ 391, 424 ] ] }, { "id": "6895", "type": "abstract", "text": [ "A total of 8861,260 and 10,957,957 high quality reads with 20 and 23 conserved miRNAs were obtained in females and males, respectively. " ], "offsets": [ [ 425, 561 ] ] }, { "id": "6896", "type": "abstract", "text": [ "The objective of this study was to determine and characterize miRNAs of female and male adults of A. cantonensis by Solexa deep sequencing. " ], "offsets": [ [ 562, 702 ] ] }, { "id": "6897", "type": "abstract", "text": [ "microRNAs (miRNAs) are endogenous small non-coding RNAs that play crucial roles in gene expression regulation, cellular function and defense, homeostasis and pathogenesis. " ], "offsets": [ [ 703, 875 ] ] }, { "id": "6898", "type": "abstract", "text": [ "Angiostrongylus cantonensis causes eosinophilic meningitis and eosinophilic pleocytosis in humans and is of significant socio-economic importance globally. " ], "offsets": [ [ 876, 1032 ] ] }, { "id": "6899", "type": "abstract", "text": [ "Angiostrongylus cantonensis: Identification and characterization of microRNAs in male and female adults. " ], "offsets": [ [ 1033, 1139 ] ] } ]

[ { "id": "6900", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 46, 51 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d147.s0.e0" } ] }, { "id": "6901", "type": "Relation_Trigger", "text": [ "regulation" ], "offsets": [ [ 128, 138 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d147.s0.e1" } ] }, { "id": "6902", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 382, 388 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d147.s1.e0" } ] }, { "id": "6903", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 398, 403 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d147.s2.e0" } ] }, { "id": "6904", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 504, 510 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d147.s3.e0" } ] }, { "id": "6905", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 624, 630 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d147.s4.e0" } ] }, { "id": "6906", "type": "Non-Specific_miRNAs", "text": [ "microRNAs" ], "offsets": [ [ 703, 712 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d147.s6.e0" } ] }, { "id": "6907", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 714, 720 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d147.s6.e1" } ] }, { "id": "6908", "type": "Relation_Trigger", "text": [ "expression regulation" ], "offsets": [ [ 791, 812 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d147.s6.e2" } ] }, { "id": "6909", "type": "Diseases", "text": [ "eosinophilic meningitis" ], "offsets": [ [ 911, 934 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d147.s7.e0" } ] }, { "id": "6910", "type": "Diseases", "text": [ "eosinophilic pleocytosis" ], "offsets": [ [ 939, 963 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d147.s7.e1" } ] }, { "id": "6911", "type": "Species", "text": [ "humans" ], "offsets": [ [ 967, 973 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d147.s7.e2" } ] }, { "id": "6912", "type": "Non-Specific_miRNAs", "text": [ "microRNAs" ], "offsets": [ [ 1101, 1110 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d147.s8.e0" } ] } ]

[]

[]

[]

[ { "id": "6914", "type": "title", "text": [ "The miR-146a expression was confirmed to be present in reactive astrocytes. " ], "offsets": [ [ 0, 76 ] ] }, { "id": "6915", "type": "abstract", "text": [ "In human TLE with hippocampal sclerosis, increased astroglial expression of miR-146a was observed mainly in regions where neuronal cell loss and reactive gliosis occurred. " ], "offsets": [ [ 77, 249 ] ] }, { "id": "6916", "type": "abstract", "text": [ "The increased and persistent expression of miR-146a in reactive astrocytes supports the possible involvement of miRNAs in the modulation of the astroglial inflammatory response occurring in TLE and provides a target for future studies aimed at developing strategies against pro-epileptogenic inflammatory signalling. " ], "offsets": [ [ 250, 569 ] ] }, { "id": "6917", "type": "abstract", "text": [ "Increasing evidence supports the involvement of inflammatory and immune processes in temporal lobe epilepsy (TLE). " ], "offsets": [ [ 570, 685 ] ] }, { "id": "6918", "type": "abstract", "text": [ "Expression pattern of miR-146a, an inflammation-associated microRNA, in experimental and human temporal lobe epilepsy. " ], "offsets": [ [ 686, 806 ] ] }, { "id": "6919", "type": "abstract", "text": [ "We investigated the expression and cellular distribution of miRNA-146a (miR-146a) in a rat model of TLE as well as in human TLE. " ], "offsets": [ [ 807, 936 ] ] }, { "id": "6920", "type": "abstract", "text": [ "MicroRNAs (miRNA) represent small regulatory RNA molecules that have been shown to act as negative regulators of gene expression controlling different biological processes, including immune-system homeostasis and function. " ], "offsets": [ [ 937, 1160 ] ] }, { "id": "6921", "type": "abstract", "text": [ "Prominent upregulation of miR-146a activation was evident at 1 week after SE and persisted in the chronic phase. " ], "offsets": [ [ 1161, 1274 ] ] }, { "id": "6922", "type": "abstract", "text": [ "miR-146a analysis in rat hippocampus was performed by polymerase chain reaction and immunocytochemistry at 1 week and 3-4 months after induction of status epilepticus (SE). " ], "offsets": [ [ 1275, 1448 ] ] } ]

[ { "id": "6923", "type": "Specific_miRNAs", "text": [ "miR-146a" ], "offsets": [ [ 4, 12 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d148.s0.e0" } ] }, { "id": "6924", "type": "Relation_Trigger", "text": [ "increased astroglial expression" ], "offsets": [ [ 118, 149 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d148.s1.e0" } ] }, { "id": "6925", "type": "Diseases", "text": [ "TLE" ], "offsets": [ [ 86, 89 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d148.s1.e1" } ] }, { "id": "6926", "type": "Specific_miRNAs", "text": [ "miR-146a" ], "offsets": [ [ 153, 161 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d148.s1.e2" } ] }, { "id": "6927", "type": "Diseases", "text": [ "hippocampal sclerosis" ], "offsets": [ [ 95, 116 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d148.s1.e3" } ] }, { "id": "6928", "type": "Diseases", "text": [ "gliosis" ], "offsets": [ [ 231, 238 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d148.s1.e4" } ] }, { "id": "6929", "type": "Species", "text": [ "human" ], "offsets": [ [ 80, 85 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d148.s1.e5" } ] }, { "id": "6930", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 362, 368 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d148.s2.e0" } ] }, { "id": "6931", "type": "Relation_Trigger", "text": [ "increased and persistent expression" ], "offsets": [ [ 254, 289 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d148.s2.e1" } ] }, { "id": "6932", "type": "Relation_Trigger", "text": [ "modulation" ], "offsets": [ [ 376, 386 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d148.s2.e2" } ] }, { "id": "6933", "type": "Diseases", "text": [ "TLE" ], "offsets": [ [ 440, 443 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d148.s2.e3" } ] }, { "id": "6934", "type": "Specific_miRNAs", "text": [ "miR-146a" ], "offsets": [ [ 293, 301 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d148.s2.e4" } ] }, { "id": "6935", "type": "Relation_Trigger", "text": [ "target" ], "offsets": [ [ 459, 465 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d148.s2.e5" } ] }, { "id": "6936", "type": "Diseases", "text": [ "temporal lobe epilepsy" ], "offsets": [ [ 655, 677 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d148.s3.e0" } ] }, { "id": "6937", "type": "Diseases", "text": [ "TLE" ], "offsets": [ [ 679, 682 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d148.s3.e1" } ] }, { "id": "6938", "type": "Diseases", "text": [ "temporal lobe epilepsy" ], "offsets": [ [ 781, 803 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d148.s4.e0" } ] }, { "id": "6939", "type": "Non-Specific_miRNAs", "text": [ "microRNA" ], "offsets": [ [ 745, 753 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d148.s4.e1" } ] }, { "id": "6940", "type": "Specific_miRNAs", "text": [ "miR-146a" ], "offsets": [ [ 708, 716 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d148.s4.e2" } ] }, { "id": "6941", "type": "Diseases", "text": [ "inflammation" ], "offsets": [ [ 721, 733 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d148.s4.e3" } ] }, { "id": "6942", "type": "Species", "text": [ "human" ], "offsets": [ [ 775, 780 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d148.s4.e4" } ] }, { "id": "6943", "type": "Diseases", "text": [ "TLE" ], "offsets": [ [ 931, 934 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d148.s5.e0" } ] }, { "id": "6944", "type": "Specific_miRNAs", "text": [ "miRNA-146a" ], "offsets": [ [ 867, 877 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d148.s5.e1" } ] }, { "id": "6945", "type": "Specific_miRNAs", "text": [ "miR-146a" ], "offsets": [ [ 879, 887 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d148.s5.e2" } ] }, { "id": "6946", "type": "Diseases", "text": [ "TLE" ], "offsets": [ [ 907, 910 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d148.s5.e3" } ] }, { "id": "6947", "type": "Species", "text": [ "rat" ], "offsets": [ [ 894, 897 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d148.s5.e4" } ] }, { "id": "6948", "type": "Species", "text": [ "human" ], "offsets": [ [ 925, 930 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d148.s5.e5" } ] }, { "id": "6949", "type": "Non-Specific_miRNAs", "text": [ "MicroRNAs" ], "offsets": [ [ 937, 946 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d148.s6.e0" } ] }, { "id": "6950", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 948, 953 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d148.s6.e1" } ] }, { "id": "6951", "type": "Relation_Trigger", "text": [ "regulatory" ], "offsets": [ [ 971, 981 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d148.s6.e2" } ] }, { "id": "6952", "type": "Relation_Trigger", "text": [ "negative regulators" ], "offsets": [ [ 1027, 1046 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d148.s6.e3" } ] }, { "id": "6953", "type": "Relation_Trigger", "text": [ "regulators of gene expression" ], "offsets": [ [ 1036, 1065 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d148.s6.e4" } ] }, { "id": "6954", "type": "Diseases", "text": [ "SE" ], "offsets": [ [ 1235, 1237 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d148.s7.e0" } ] }, { "id": "6955", "type": "Relation_Trigger", "text": [ "upregulation" ], "offsets": [ [ 1171, 1183 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d148.s7.e1" } ] }, { "id": "6956", "type": "Relation_Trigger", "text": [ "activation" ], "offsets": [ [ 1196, 1206 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d148.s7.e2" } ] }, { "id": "6957", "type": "Specific_miRNAs", "text": [ "miR-146a" ], "offsets": [ [ 1187, 1195 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d148.s7.e3" } ] }, { "id": "6958", "type": "Diseases", "text": [ "status epilepticus" ], "offsets": [ [ 1423, 1441 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d148.s8.e0" } ] }, { "id": "6959", "type": "Diseases", "text": [ "SE" ], "offsets": [ [ 1443, 1445 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d148.s8.e1" } ] }, { "id": "6960", "type": "Specific_miRNAs", "text": [ "miR-146a" ], "offsets": [ [ 1275, 1283 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d148.s8.e2" } ] }, { "id": "6961", "type": "Species", "text": [ "rat" ], "offsets": [ [ 1296, 1299 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d148.s8.e3" } ] } ]

[]

[]

[ { "id": "6962", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d148.s1.e2", "arg2_id": "miRNA-corp.d148.s1.e1", "normalized": [] }, { "id": "6963", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d148.s1.e2", "arg2_id": "miRNA-corp.d148.s1.e3", "normalized": [] }, { "id": "6964", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d148.s1.e2", "arg2_id": "miRNA-corp.d148.s1.e4", "normalized": [] }, { "id": "6965", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d148.s2.e4", "arg2_id": "miRNA-corp.d148.s2.e3", "normalized": [] }, { "id": "6966", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d148.s2.e0", "arg2_id": "miRNA-corp.d148.s2.e3", "normalized": [] }, { "id": "6967", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d148.s4.e2", "arg2_id": "miRNA-corp.d148.s4.e0", "normalized": [] }, { "id": "6968", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d148.s4.e2", "arg2_id": "miRNA-corp.d148.s4.e3", "normalized": [] }, { "id": "6969", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d148.s4.e1", "arg2_id": "miRNA-corp.d148.s4.e0", "normalized": [] }, { "id": "6970", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d148.s4.e1", "arg2_id": "miRNA-corp.d148.s4.e3", "normalized": [] }, { "id": "6971", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d148.s5.e1", "arg2_id": "miRNA-corp.d148.s5.e0", "normalized": [] }, { "id": "6972", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d148.s5.e1", "arg2_id": "miRNA-corp.d148.s5.e3", "normalized": [] }, { "id": "6973", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d148.s5.e2", "arg2_id": "miRNA-corp.d148.s5.e0", "normalized": [] }, { "id": "6974", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d148.s5.e2", "arg2_id": "miRNA-corp.d148.s5.e3", "normalized": [] }, { "id": "6975", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d148.s7.e3", "arg2_id": "miRNA-corp.d148.s7.e0", "normalized": [] }, { "id": "6976", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d148.s8.e2", "arg2_id": "miRNA-corp.d148.s8.e0", "normalized": [] }, { "id": "6977", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d148.s8.e2", "arg2_id": "miRNA-corp.d148.s8.e1", "normalized": [] } ]

[ { "id": "6979", "type": "title", "text": [ "However, none of these individuals reported here have epilepsy, although two have an abnormal EEG. " ], "offsets": [ [ 0, 99 ] ] }, { "id": "6980", "type": "abstract", "text": [ "CONCLUSIONS: The phenotype of chromosome 15q13.2q13.3 BP4-BP5 microdeletion/duplication syndrome may include features of autism spectrum disorder, a variety of neuropsychiatric disorders, and cognitive impairment. " ], "offsets": [ [ 100, 314 ] ] }, { "id": "6981", "type": "abstract", "text": [ "PATIENTS: DNA samples from 1445 unrelated patients submitted consecutively for clinical array comparative genomic hybridisation (CGH) testing at Children's Hospital Boston and DNA samples from 1441 individuals with autism from 751 families in the Autism Genetic Resource Exchange (AGRE) repository. " ], "offsets": [ [ 315, 614 ] ] }, { "id": "6982", "type": "abstract", "text": [ "RESULTS: We report the clinical features of five patients with a BP4-BP5 deletion, three with a BP4-BP5 duplication, and two with an overlapping but smaller duplication identified by whole genome high resolution oligonucleotide array CGH. " ], "offsets": [ [ 615, 854 ] ] }, { "id": "6983", "type": "abstract", "text": [ "Microdeletion/duplication at 15q13.2q13.3 among individuals with features of autism and other neuropsychiatric disorders. " ], "offsets": [ [ 855, 978 ] ] }, { "id": "6984", "type": "abstract", "text": [ "BACKGROUND: Segmental duplications at breakpoints (BP4-BP5) of chromosome 15q13.2q13.3 mediate a recurrent genomic imbalance syndrome associated with mental retardation, epilepsy, and/or electroencephalogram (EEG) abnormalities. " ], "offsets": [ [ 979, 1208 ] ] }, { "id": "6985", "type": "abstract", "text": [ "BP4-BP5 covers approximately 1.5 Mb (chr15:28.719-30.298 Mb) and includes six reference genes and 1 miRNA gene, while the smaller duplications cover approximately 500 kb (chr15:28.902-29.404 Mb) and contain three reference genes and one miRNA gene. " ], "offsets": [ [ 1209, 1458 ] ] }, { "id": "6986", "type": "abstract", "text": [ "Cognitive impairment varied from moderate mental retardation to normal IQ with learning disability. " ], "offsets": [ [ 1459, 1559 ] ] }, { "id": "6987", "type": "abstract", "text": [ "These BP4-BP5 deletion cases exhibit minor dysmorphic features, significant expressive language deficits, and a spectrum of neuropsychiatric impairments that include autism spectrum disorder, attention deficit hyperactivity disorder, anxiety disorder, and mood disorder. " ], "offsets": [ [ 1560, 1831 ] ] }, { "id": "6988", "type": "abstract", "text": [ "The BP4-BP5 deletion and duplication events span CHRNA7, a candidate gene for seizures. " ], "offsets": [ [ 1832, 1920 ] ] } ]

[ { "id": "6989", "type": "Diseases", "text": [ "epilepsy" ], "offsets": [ [ 54, 62 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d149.s0.e0" } ] }, { "id": "6990", "type": "Diseases", "text": [ "autism spectrum disorder" ], "offsets": [ [ 221, 245 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d149.s1.e0" } ] }, { "id": "6991", "type": "Diseases", "text": [ "neuropsychiatric disorders" ], "offsets": [ [ 260, 286 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d149.s1.e1" } ] }, { "id": "6992", "type": "Diseases", "text": [ "cognitive impairment" ], "offsets": [ [ 292, 312 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d149.s1.e2" } ] }, { "id": "6993", "type": "Diseases", "text": [ "autism" ], "offsets": [ [ 530, 536 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d149.s3.e0" } ] }, { "id": "6994", "type": "Species", "text": [ "PATIENTS" ], "offsets": [ [ 315, 323 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d149.s3.e1" } ] }, { "id": "6995", "type": "Diseases", "text": [ "Autism" ], "offsets": [ [ 562, 568 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d149.s3.e2" } ] }, { "id": "6996", "type": "Species", "text": [ "patients" ], "offsets": [ [ 357, 365 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d149.s3.e3" } ] }, { "id": "6997", "type": "Species", "text": [ "Children's" ], "offsets": [ [ 460, 470 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d149.s3.e4" } ] }, { "id": "6998", "type": "Species", "text": [ "patients" ], "offsets": [ [ 664, 672 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d149.s4.e0" } ] }, { "id": "6999", "type": "Diseases", "text": [ "autism" ], "offsets": [ [ 932, 938 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d149.s5.e0" } ] }, { "id": "7000", "type": "Diseases", "text": [ "neuropsychiatric disorders" ], "offsets": [ [ 949, 975 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d149.s5.e1" } ] }, { "id": "7001", "type": "Diseases", "text": [ "epilepsy" ], "offsets": [ [ 1149, 1157 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d149.s6.e0" } ] }, { "id": "7002", "type": "Relation_Trigger", "text": [ "associated" ], "offsets": [ [ 1113, 1123 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d149.s6.e1" } ] }, { "id": "7003", "type": "Diseases", "text": [ "mental retardation" ], "offsets": [ [ 1129, 1147 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d149.s6.e2" } ] }, { "id": "7004", "type": "Diseases", "text": [ "electroencephalogram (EEG) abnormalities" ], "offsets": [ [ 1166, 1206 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d149.s6.e3" } ] }, { "id": "7005", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1309, 1314 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d149.s7.e0" } ] }, { "id": "7006", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1446, 1451 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d149.s7.e1" } ] }, { "id": "7007", "type": "Diseases", "text": [ "mental retardation" ], "offsets": [ [ 1501, 1519 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d149.s8.e0" } ] }, { "id": "7008", "type": "Diseases", "text": [ "Cognitive impairment" ], "offsets": [ [ 1459, 1479 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d149.s8.e1" } ] }, { "id": "7009", "type": "Diseases", "text": [ "learning disability" ], "offsets": [ [ 1538, 1557 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d149.s8.e2" } ] }, { "id": "7010", "type": "Diseases", "text": [ "autism spectrum disorder" ], "offsets": [ [ 1726, 1750 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d149.s9.e0" } ] }, { "id": "7011", "type": "Diseases", "text": [ "attention deficit hyperactivity disorder" ], "offsets": [ [ 1752, 1792 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d149.s9.e1" } ] }, { "id": "7012", "type": "Diseases", "text": [ "anxiety disorder" ], "offsets": [ [ 1794, 1810 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d149.s9.e2" } ] }, { "id": "7013", "type": "Diseases", "text": [ "mood disorder" ], "offsets": [ [ 1816, 1829 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d149.s9.e3" } ] }, { "id": "7014", "type": "Diseases", "text": [ "neuropsychiatric impairments" ], "offsets": [ [ 1684, 1712 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d149.s9.e4" } ] }, { "id": "7015", "type": "Diseases", "text": [ "seizures" ], "offsets": [ [ 1910, 1918 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d149.s10.e0" } ] } ]

[]

[]

[]

[ { "id": "7017", "type": "title", "text": [ "The KIAA0226 gene encodes a protein that we named rundataxin, with two conserved domains: an N-terminal RUN domain and a C-terminal domain containing a diacylglycerol binding-like motif. " ], "offsets": [ [ 0, 187 ] ] }, { "id": "7018", "type": "abstract", "text": [ "Mutation screening of all coding sequences revealed a single nucleotide deletion, 2927delC, in exon 19 of the KIAA0226 gene, which results in a frame shift of the C-terminal domain (p.Ala943ValfsX146). " ], "offsets": [ [ 188, 390 ] ] }, { "id": "7019", "type": "abstract", "text": [ "The rundataxin pathway appears therefore distinct from the ataxia pathways involving deficiency in mitochondrial or nuclear proteins and broadens the range of mechanisms leading to recessive ataxias. " ], "offsets": [ [ 391, 593 ] ] }, { "id": "7020", "type": "abstract", "text": [ "The closest paralogue of rundataxin, the plekstrin homology domain family member M1, has been shown to colocalize with Rab7, a small GTPase associated with late endosomes/lysosomes, suggesting that rundataxin may also be associated with vesicular trafficking and signalling pathways through its RUN and diacylglycerol binding-like domains. " ], "offsets": [ [ 594, 934 ] ] }, { "id": "7021", "type": "abstract", "text": [ "The three patients presented with childhood onset gait and limb ataxia, dysarthria and had limited walking without aid into their teenage years. " ], "offsets": [ [ 935, 1080 ] ] }, { "id": "7022", "type": "abstract", "text": [ "We have identified a novel form of recessive ataxia that segregates in three children of a large consanguineous Saudi Arabian family. " ], "offsets": [ [ 1081, 1215 ] ] }, { "id": "7023", "type": "abstract", "text": [ "Two patients developed epilepsy at 7 months without relapse after treatment, and mental retardation. " ], "offsets": [ [ 1216, 1317 ] ] }, { "id": "7024", "type": "abstract", "text": [ "Rundataxin, a novel protein with RUN and diacylglycerol binding domains, is mutant in a new recessive ataxia. " ], "offsets": [ [ 1318, 1429 ] ] } ]

[ { "id": "7025", "type": "Genes/Proteins", "text": [ "rundataxin" ], "offsets": [ [ 50, 60 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d150.s0.e0" } ] }, { "id": "7026", "type": "Genes/Proteins", "text": [ "KIAA0226" ], "offsets": [ [ 4, 12 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d150.s0.e1" } ] }, { "id": "7027", "type": "Genes/Proteins", "text": [ "KIAA0226" ], "offsets": [ [ 298, 306 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d150.s1.e0" } ] }, { "id": "7028", "type": "Diseases", "text": [ "ataxia" ], "offsets": [ [ 450, 456 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d150.s2.e0" } ] }, { "id": "7029", "type": "Diseases", "text": [ "ataxias" ], "offsets": [ [ 582, 589 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d150.s2.e1" } ] }, { "id": "7030", "type": "Relation_Trigger", "text": [ "associated" ], "offsets": [ [ 734, 744 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d150.s3.e0" } ] }, { "id": "7031", "type": "Relation_Trigger", "text": [ "associated" ], "offsets": [ [ 815, 825 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d150.s3.e1" } ] }, { "id": "7032", "type": "Genes/Proteins", "text": [ "rundataxin" ], "offsets": [ [ 619, 629 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d150.s3.e2" } ] }, { "id": "7033", "type": "Genes/Proteins", "text": [ "rundataxin" ], "offsets": [ [ 792, 802 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d150.s3.e3" } ] }, { "id": "7034", "type": "Diseases", "text": [ "ataxia" ], "offsets": [ [ 999, 1005 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d150.s4.e0" } ] }, { "id": "7035", "type": "Diseases", "text": [ "dysarthria" ], "offsets": [ [ 1007, 1017 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d150.s4.e1" } ] }, { "id": "7036", "type": "Species", "text": [ "patients" ], "offsets": [ [ 945, 953 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d150.s4.e2" } ] }, { "id": "7037", "type": "Diseases", "text": [ "ataxia" ], "offsets": [ [ 1126, 1132 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d150.s5.e0" } ] }, { "id": "7038", "type": "Species", "text": [ "children" ], "offsets": [ [ 1158, 1166 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d150.s5.e1" } ] }, { "id": "7039", "type": "Diseases", "text": [ "mental retardation" ], "offsets": [ [ 1297, 1315 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d150.s7.e0" } ] }, { "id": "7040", "type": "Diseases", "text": [ "epilepsy" ], "offsets": [ [ 1239, 1247 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d150.s7.e1" } ] }, { "id": "7041", "type": "Species", "text": [ "patients developed" ], "offsets": [ [ 1220, 1238 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d150.s7.e2" } ] }, { "id": "7042", "type": "Relation_Trigger", "text": [ "binding" ], "offsets": [ [ 1374, 1381 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d150.s8.e0" } ] }, { "id": "7043", "type": "Genes/Proteins", "text": [ "Rundataxin" ], "offsets": [ [ 1318, 1328 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d150.s8.e1" } ] }, { "id": "7044", "type": "Diseases", "text": [ "ataxia" ], "offsets": [ [ 1420, 1426 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d150.s8.e2" } ] } ]

[]

[]

[]

[ { "id": "7046", "type": "title", "text": [ "These tumors arise in the cerebellum and may attribute their origins to deregulated proliferation of neural progenitor cells during development. " ], "offsets": [ [ 0, 145 ] ] }, { "id": "7047", "type": "abstract", "text": [ "However, only a few studies to date have focused on the role of miRNAs in medulloblastoma, the most common malignant pediatric brain tumor. " ], "offsets": [ [ 146, 286 ] ] }, { "id": "7048", "type": "abstract", "text": [ "MiRNA expression profiling of both mouse and human medulloblastomas has led to the identification of signatures correlating with the molecular subgroups of medulloblastoma, tumor diagnosis and response to treatment, as well as novel targets of potential clinical relevance. " ], "offsets": [ [ 287, 561 ] ] }, { "id": "7049", "type": "abstract", "text": [ "Understanding the interplay between normal brain development and medulloblastoma pathogenesis is necessary in order for more efficient, less toxic targeted therapies to be developed and implemented. " ], "offsets": [ [ 562, 761 ] ] }, { "id": "7050", "type": "abstract", "text": [ "Normal and oncogenic roles for microRNAs in the developing brain. " ], "offsets": [ [ 762, 829 ] ] }, { "id": "7051", "type": "abstract", "text": [ "Emerging evidence indicates that miRNAs are key players in mammalian development that, when altered, contribute to tumorigenesis. " ], "offsets": [ [ 830, 960 ] ] }, { "id": "7052", "type": "abstract", "text": [ "MicroRNAS (miRNAs) are small endogenous non-coding RNAs that play important roles in many different biological processes including proliferation, differentiation and apoptosis through silencing of target genes. " ], "offsets": [ [ 961, 1172 ] ] }, { "id": "7053", "type": "abstract", "text": [ "This review summarizes the recent miRNA literature in both medulloblastoma and normal brain development. " ], "offsets": [ [ 1173, 1280 ] ] } ]

[ { "id": "7054", "type": "Diseases", "text": [ "tumors" ], "offsets": [ [ 6, 12 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d151.s0.e0" } ] }, { "id": "7055", "type": "Relation_Trigger", "text": [ "deregulated" ], "offsets": [ [ 72, 83 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d151.s0.e1" } ] }, { "id": "7056", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 210, 216 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d151.s1.e0" } ] }, { "id": "7057", "type": "Diseases", "text": [ "medulloblastoma" ], "offsets": [ [ 220, 235 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d151.s1.e1" } ] }, { "id": "7058", "type": "Diseases", "text": [ "brain tumor" ], "offsets": [ [ 273, 284 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d151.s1.e2" } ] }, { "id": "7059", "type": "Non-Specific_miRNAs", "text": [ "MiRNA" ], "offsets": [ [ 287, 292 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d151.s2.e0" } ] }, { "id": "7060", "type": "Diseases", "text": [ "medulloblastoma" ], "offsets": [ [ 443, 458 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d151.s2.e1" } ] }, { "id": "7061", "type": "Relation_Trigger", "text": [ "novel targets" ], "offsets": [ [ 514, 527 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d151.s2.e2" } ] }, { "id": "7062", "type": "Diseases", "text": [ "medulloblastomas" ], "offsets": [ [ 338, 354 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d151.s2.e3" } ] }, { "id": "7063", "type": "Relation_Trigger", "text": [ "targets of potential" ], "offsets": [ [ 520, 540 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d151.s2.e4" } ] }, { "id": "7064", "type": "Relation_Trigger", "text": [ "correlating" ], "offsets": [ [ 399, 410 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d151.s2.e5" } ] }, { "id": "7065", "type": "Diseases", "text": [ "tumor" ], "offsets": [ [ 460, 465 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d151.s2.e6" } ] }, { "id": "7066", "type": "Species", "text": [ "mouse" ], "offsets": [ [ 322, 327 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d151.s2.e7" } ] }, { "id": "7067", "type": "Species", "text": [ "human" ], "offsets": [ [ 332, 337 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d151.s2.e8" } ] }, { "id": "7068", "type": "Diseases", "text": [ "medulloblastoma" ], "offsets": [ [ 627, 642 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d151.s3.e0" } ] }, { "id": "7069", "type": "Relation_Trigger", "text": [ "targeted" ], "offsets": [ [ 709, 717 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d151.s3.e1" } ] }, { "id": "7070", "type": "Non-Specific_miRNAs", "text": [ "microRNAs" ], "offsets": [ [ 793, 802 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d151.s4.e0" } ] }, { "id": "7071", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 863, 869 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d151.s5.e0" } ] }, { "id": "7072", "type": "Non-Specific_miRNAs", "text": [ "MicroRNAS" ], "offsets": [ [ 961, 970 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d151.s6.e0" } ] }, { "id": "7073", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 972, 978 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d151.s6.e1" } ] }, { "id": "7074", "type": "Relation_Trigger", "text": [ "target" ], "offsets": [ [ 1158, 1164 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d151.s6.e2" } ] }, { "id": "7075", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1207, 1212 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d151.s7.e0" } ] }, { "id": "7076", "type": "Diseases", "text": [ "medulloblastoma" ], "offsets": [ [ 1232, 1247 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d151.s7.e1" } ] } ]

[]

[]

[ { "id": "7077", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d151.s1.e0", "arg2_id": "miRNA-corp.d151.s1.e1", "normalized": [] }, { "id": "7078", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d151.s1.e0", "arg2_id": "miRNA-corp.d151.s1.e2", "normalized": [] }, { "id": "7079", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d151.s2.e0", "arg2_id": "miRNA-corp.d151.s2.e1", "normalized": [] }, { "id": "7080", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d151.s2.e0", "arg2_id": "miRNA-corp.d151.s2.e3", "normalized": [] }, { "id": "7081", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d151.s2.e0", "arg2_id": "miRNA-corp.d151.s2.e6", "normalized": [] }, { "id": "7082", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d151.s7.e0", "arg2_id": "miRNA-corp.d151.s7.e1", "normalized": [] } ]

[ { "id": "7084", "type": "title", "text": [ "A miRNA signature of prion induced neurodegeneration. " ], "offsets": [ [ 0, 55 ] ] }, { "id": "7085", "type": "abstract", "text": [ "Compelling evidence links miRNAs to the control of neuronal development and differentiation, however, little is known about their role in neurodegeneration. " ], "offsets": [ [ 56, 213 ] ] }, { "id": "7086", "type": "abstract", "text": [ "MicroRNAs (miRNAs) are small, non-coding RNA molecules which are emerging as key regulators of numerous cellular processes. " ], "offsets": [ [ 214, 338 ] ] }, { "id": "7087", "type": "abstract", "text": [ "We determined 15 miRNAs were de-regulated during the disease processes; miR-342-3p, miR-320, let-7b, miR-328, miR-128, miR-139-5p and miR-146a were over 2.5 fold up-regulated and miR-338-3p and miR-337-3p over 2.5 fold down-regulated. " ], "offsets": [ [ 339, 574 ] ] }, { "id": "7088", "type": "abstract", "text": [ "We used microarrays and RT-PCR to profile miRNA expression changes in the brains of mice infected with mouse-adapted scrapie. " ], "offsets": [ [ 575, 701 ] ] }, { "id": "7089", "type": "abstract", "text": [ "De-regulation of a unique subset of miRNAs suggests a conserved, disease-specific pattern of differentially expressed miRNAs is associated with prion-induced neurodegeneration. " ], "offsets": [ [ 702, 879 ] ] }, { "id": "7090", "type": "abstract", "text": [ "Only one of these miRNAs, miR-128, has previously been shown to be de-regulated in neurodegenerative disease. " ], "offsets": [ [ 880, 990 ] ] }, { "id": "7091", "type": "abstract", "text": [ "Computational analysis predicted numerous potential gene targets of these miRNAs, including 119 genes previously determined to be also de-regulated in mouse scrapie. " ], "offsets": [ [ 991, 1157 ] ] }, { "id": "7092", "type": "abstract", "text": [ "We used a co-ordinated approach to integrate miRNA and mRNA profiling, bioinformatic predictions and biochemical validation to determine miRNA regulated processes and genes potentially involved in disease progression. " ], "offsets": [ [ 1158, 1376 ] ] }, { "id": "7093", "type": "abstract", "text": [ "In particular, a correlation between miRNA expression and putative gene targets involved in intracellular protein-degradation pathways and signaling pathways related to cell death, synapse function and neurogenesis was identified. " ], "offsets": [ [ 1377, 1610 ] ] } ]

[ { "id": "7094", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 2, 7 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d152.s0.e0" } ] }, { "id": "7095", "type": "Genes/Proteins", "text": [ "prion" ], "offsets": [ [ 21, 26 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d152.s0.e1" } ] }, { "id": "7096", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 82, 88 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d152.s1.e0" } ] }, { "id": "7097", "type": "Non-Specific_miRNAs", "text": [ "MicroRNAs" ], "offsets": [ [ 214, 223 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d152.s2.e0" } ] }, { "id": "7098", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 225, 231 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d152.s2.e1" } ] }, { "id": "7099", "type": "Relation_Trigger", "text": [ "regulators" ], "offsets": [ [ 295, 305 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d152.s2.e2" } ] }, { "id": "7100", "type": "Specific_miRNAs", "text": [ "miR-342-3p" ], "offsets": [ [ 411, 421 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d152.s3.e0" } ] }, { "id": "7101", "type": "Specific_miRNAs", "text": [ "miR-320" ], "offsets": [ [ 423, 430 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d152.s3.e1" } ] }, { "id": "7102", "type": "Specific_miRNAs", "text": [ "let-7b" ], "offsets": [ [ 432, 438 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d152.s3.e2" } ] }, { "id": "7103", "type": "Specific_miRNAs", "text": [ "miR-328" ], "offsets": [ [ 440, 447 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d152.s3.e3" } ] }, { "id": "7104", "type": "Specific_miRNAs", "text": [ "miR-128" ], "offsets": [ [ 449, 456 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d152.s3.e4" } ] }, { "id": "7105", "type": "Specific_miRNAs", "text": [ "miR-139-5p" ], "offsets": [ [ 458, 468 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d152.s3.e5" } ] }, { "id": "7106", "type": "Specific_miRNAs", "text": [ "miR-146a" ], "offsets": [ [ 473, 481 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d152.s3.e6" } ] }, { "id": "7107", "type": "Specific_miRNAs", "text": [ "miR-338-3p" ], "offsets": [ [ 518, 528 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d152.s3.e7" } ] }, { "id": "7108", "type": "Specific_miRNAs", "text": [ "miR-337-3p" ], "offsets": [ [ 533, 543 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d152.s3.e8" } ] }, { "id": "7109", "type": "Relation_Trigger", "text": [ "de-regulated" ], "offsets": [ [ 368, 380 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d152.s3.e9" } ] }, { "id": "7110", "type": "Relation_Trigger", "text": [ "up-regulated" ], "offsets": [ [ 501, 513 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d152.s3.e10" } ] }, { "id": "7111", "type": "Relation_Trigger", "text": [ "down-regulated" ], "offsets": [ [ 558, 572 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d152.s3.e11" } ] }, { "id": "7112", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 356, 362 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d152.s3.e12" } ] }, { "id": "7113", "type": "Diseases", "text": [ "scrapie" ], "offsets": [ [ 692, 699 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d152.s4.e0" } ] }, { "id": "7114", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 617, 622 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d152.s4.e1" } ] }, { "id": "7115", "type": "Relation_Trigger", "text": [ "expression changes" ], "offsets": [ [ 623, 641 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d152.s4.e2" } ] }, { "id": "7116", "type": "Species", "text": [ "mouse" ], "offsets": [ [ 678, 683 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d152.s4.e3" } ] }, { "id": "7117", "type": "Species", "text": [ "mice" ], "offsets": [ [ 659, 663 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d152.s4.e4" } ] }, { "id": "7118", "type": "Relation_Trigger", "text": [ "De-regulation" ], "offsets": [ [ 702, 715 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d152.s5.e0" } ] }, { "id": "7119", "type": "Relation_Trigger", "text": [ "differentially expressed" ], "offsets": [ [ 795, 819 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d152.s5.e1" } ] }, { "id": "7120", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 738, 744 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d152.s5.e2" } ] }, { "id": "7121", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 820, 826 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d152.s5.e3" } ] }, { "id": "7122", "type": "Genes/Proteins", "text": [ "prion" ], "offsets": [ [ 846, 851 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d152.s5.e4" } ] }, { "id": "7123", "type": "Relation_Trigger", "text": [ "associated" ], "offsets": [ [ 830, 840 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d152.s5.e5" } ] }, { "id": "7124", "type": "Specific_miRNAs", "text": [ "miR-128" ], "offsets": [ [ 906, 913 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d152.s6.e0" } ] }, { "id": "7125", "type": "Relation_Trigger", "text": [ "de-regulated" ], "offsets": [ [ 947, 959 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d152.s6.e1" } ] }, { "id": "7126", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 898, 904 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d152.s6.e2" } ] }, { "id": "7127", "type": "Diseases", "text": [ "neurodegenerative disease" ], "offsets": [ [ 963, 988 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d152.s6.e3" } ] }, { "id": "7128", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1065, 1071 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d152.s7.e0" } ] }, { "id": "7129", "type": "Relation_Trigger", "text": [ "targets" ], "offsets": [ [ 1048, 1055 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d152.s7.e1" } ] }, { "id": "7130", "type": "Diseases", "text": [ "scrapie" ], "offsets": [ [ 1148, 1155 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d152.s7.e2" } ] }, { "id": "7131", "type": "Relation_Trigger", "text": [ "de-regulated" ], "offsets": [ [ 1126, 1138 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d152.s7.e3" } ] }, { "id": "7132", "type": "Species", "text": [ "mouse" ], "offsets": [ [ 1142, 1147 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d152.s7.e4" } ] }, { "id": "7133", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1203, 1208 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d152.s8.e0" } ] }, { "id": "7134", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1295, 1300 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d152.s8.e1" } ] }, { "id": "7135", "type": "Relation_Trigger", "text": [ "regulated" ], "offsets": [ [ 1301, 1310 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d152.s8.e2" } ] }, { "id": "7136", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1414, 1419 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d152.s9.e0" } ] }, { "id": "7137", "type": "Relation_Trigger", "text": [ "correlation between miRNA expression" ], "offsets": [ [ 1394, 1430 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d152.s9.e1" } ] }, { "id": "7138", "type": "Relation_Trigger", "text": [ "targets" ], "offsets": [ [ 1449, 1456 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d152.s9.e2" } ] } ]

[]

[]

[ { "id": "7139", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d152.s0.e0", "arg2_id": "miRNA-corp.d152.s0.e1", "normalized": [] }, { "id": "7140", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d152.s4.e1", "arg2_id": "miRNA-corp.d152.s4.e0", "normalized": [] }, { "id": "7141", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d152.s5.e2", "arg2_id": "miRNA-corp.d152.s5.e4", "normalized": [] }, { "id": "7142", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d152.s5.e3", "arg2_id": "miRNA-corp.d152.s5.e4", "normalized": [] }, { "id": "7143", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d152.s6.e2", "arg2_id": "miRNA-corp.d152.s6.e3", "normalized": [] }, { "id": "7144", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d152.s6.e0", "arg2_id": "miRNA-corp.d152.s6.e3", "normalized": [] }, { "id": "7145", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d152.s7.e0", "arg2_id": "miRNA-corp.d152.s7.e2", "normalized": [] } ]

[ { "id": "7147", "type": "title", "text": [ "Type III RNase Dicer is responsible for the maturation and function of microRNA (miRNA) molecules in the cell. " ], "offsets": [ [ 0, 111 ] ] }, { "id": "7148", "type": "abstract", "text": [ "Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration. " ], "offsets": [ [ 112, 234 ] ] }, { "id": "7149", "type": "abstract", "text": [ "Here we show that the absence of Dicer in the adult forebrain is accompanied by a mixed neurodegenerative phenotype. " ], "offsets": [ [ 235, 352 ] ] }, { "id": "7150", "type": "abstract", "text": [ "It is now well-documented that Dicer and the fine-tuning of the miRNA gene network are important for neuronal integrity. " ], "offsets": [ [ 353, 474 ] ] }, { "id": "7151", "type": "abstract", "text": [ "We further demonstrate that miRNAs belonging to the miR-15 family are potent regulators of ERK1 expression in mouse neuronal cells and co-expressed with ERK1/2 in vivo. " ], "offsets": [ [ 475, 644 ] ] }, { "id": "7152", "type": "abstract", "text": [ "Finally, we show that miR-15a is specifically downregulated in Alzheimer's disease brain. " ], "offsets": [ [ 645, 735 ] ] }, { "id": "7153", "type": "abstract", "text": [ "Interestingly, neuronal degeneration coincides with the hyperphosphorylation of endogenous tau at several epitopes previously associated with neurofibrillary pathology. " ], "offsets": [ [ 736, 905 ] ] }, { "id": "7154", "type": "abstract", "text": [ "Transcriptome analysis of enzymes involved in tau phosphorylation identified ERK1 as one of the candidate kinases responsible for this event in vivo. " ], "offsets": [ [ 906, 1056 ] ] }, { "id": "7155", "type": "abstract", "text": [ "In summary, these results support the hypothesis that changes in the miRNA network may contribute to a neurodegenerative phenotype by affecting tau phosphorylation. " ], "offsets": [ [ 1057, 1224 ] ] } ]

[ { "id": "7156", "type": "Genes/Proteins", "text": [ "Type III RNase Dicer" ], "offsets": [ [ 0, 20 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d153.s0.e0" } ] }, { "id": "7157", "type": "Non-Specific_miRNAs", "text": [ "microRNA" ], "offsets": [ [ 71, 79 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d153.s0.e1" } ] }, { "id": "7158", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 81, 86 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d153.s0.e2" } ] }, { "id": "7159", "type": "Genes/Proteins", "text": [ "Dicer" ], "offsets": [ [ 132, 137 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d153.s1.e0" } ] }, { "id": "7160", "type": "Genes/Proteins", "text": [ "Dicer" ], "offsets": [ [ 268, 273 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d153.s3.e0" } ] }, { "id": "7161", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 417, 422 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d153.s5.e0" } ] }, { "id": "7162", "type": "Genes/Proteins", "text": [ "Dicer" ], "offsets": [ [ 384, 389 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d153.s5.e1" } ] }, { "id": "7163", "type": "Genes/Proteins", "text": [ "ERK1/2" ], "offsets": [ [ 628, 634 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d153.s6.e0" } ] }, { "id": "7164", "type": "Genes/Proteins", "text": [ "ERK1" ], "offsets": [ [ 566, 570 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d153.s6.e1" } ] }, { "id": "7165", "type": "Specific_miRNAs", "text": [ "miR-15" ], "offsets": [ [ 527, 533 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d153.s6.e2" } ] }, { "id": "7166", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 503, 509 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d153.s6.e3" } ] }, { "id": "7167", "type": "Relation_Trigger", "text": [ "potent regulators" ], "offsets": [ [ 545, 562 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d153.s6.e4" } ] }, { "id": "7168", "type": "Relation_Trigger", "text": [ "co-expressed" ], "offsets": [ [ 610, 622 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d153.s6.e5" } ] }, { "id": "7169", "type": "Relation_Trigger", "text": [ "regulators of ERK1 expression" ], "offsets": [ [ 552, 581 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d153.s6.e6" } ] }, { "id": "7170", "type": "Species", "text": [ "mouse" ], "offsets": [ [ 585, 590 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d153.s6.e7" } ] }, { "id": "7171", "type": "Specific_miRNAs", "text": [ "miR-15a" ], "offsets": [ [ 667, 674 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d153.s7.e0" } ] }, { "id": "7172", "type": "Diseases", "text": [ "Alzheimer's disease" ], "offsets": [ [ 708, 727 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d153.s7.e1" } ] }, { "id": "7173", "type": "Relation_Trigger", "text": [ "downregulated" ], "offsets": [ [ 691, 704 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d153.s7.e2" } ] }, { "id": "7174", "type": "Relation_Trigger", "text": [ "associated" ], "offsets": [ [ 862, 872 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d153.s8.e0" } ] }, { "id": "7175", "type": "Diseases", "text": [ "neuronal degeneration" ], "offsets": [ [ 751, 772 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d153.s8.e1" } ] }, { "id": "7176", "type": "Genes/Proteins", "text": [ "ERK1" ], "offsets": [ [ 983, 987 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d153.s9.e0" } ] }, { "id": "7177", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1126, 1131 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d153.s10.e0" } ] } ]

[]

[]

[ { "id": "7178", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d153.s0.e2", "arg2_id": "miRNA-corp.d153.s0.e0", "normalized": [] }, { "id": "7179", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d153.s0.e1", "arg2_id": "miRNA-corp.d153.s0.e0", "normalized": [] }, { "id": "7180", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d153.s5.e0", "arg2_id": "miRNA-corp.d153.s5.e1", "normalized": [] }, { "id": "7181", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d153.s6.e3", "arg2_id": "miRNA-corp.d153.s6.e0", "normalized": [] }, { "id": "7182", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d153.s6.e3", "arg2_id": "miRNA-corp.d153.s6.e1", "normalized": [] }, { "id": "7183", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d153.s6.e2", "arg2_id": "miRNA-corp.d153.s6.e0", "normalized": [] }, { "id": "7184", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d153.s6.e2", "arg2_id": "miRNA-corp.d153.s6.e1", "normalized": [] }, { "id": "7185", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d153.s7.e0", "arg2_id": "miRNA-corp.d153.s7.e1", "normalized": [] } ]

[ { "id": "7187", "type": "title", "text": [ "MiR-21 can be induced in neurons by prolonged N-methyl-D-aspartic acid receptor stimulation, an excitotoxic process active in HIV and other neurodegenerative diseases. " ], "offsets": [ [ 0, 168 ] ] }, { "id": "7188", "type": "abstract", "text": [ "Introduction of miR-21 into human neurons leads to pathological functional defects. " ], "offsets": [ [ 169, 253 ] ] }, { "id": "7189", "type": "abstract", "text": [ "Furthermore, we show that miR-21 specifically targets the mRNA of myocyte enhancer factor 2C (MEF2C), a transcription factor crucial for neuronal function, and reduces its expression. " ], "offsets": [ [ 254, 438 ] ] }, { "id": "7190", "type": "abstract", "text": [ "MEF2C is dramatically downregulated in neurons of HIV-associated dementia patients as well as monkeys with SIVE. " ], "offsets": [ [ 439, 552 ] ] }, { "id": "7191", "type": "abstract", "text": [ "Together, this study elucidates a novel role for miR-21 in the brain, not only as a potential signature of neurological disease but also as a crucial effector of HIV induced neuronal dysfunction and neurodegeneration. " ], "offsets": [ [ 553, 773 ] ] }, { "id": "7192", "type": "abstract", "text": [ "MicroRNAs (miRNAs) play important roles in regulating a plethora of physiological and pathophysiogical processes including neurodegeneration. " ], "offsets": [ [ 774, 916 ] ] }, { "id": "7193", "type": "abstract", "text": [ "MicroRNA-21 dysregulates the expression of MEF2C in neurons in monkey and human SIV/HIV neurological disease. " ], "offsets": [ [ 917, 1028 ] ] }, { "id": "7194", "type": "abstract", "text": [ "In situ hybridization of the diseased brain sections revealed induction of miR-21 in neurons. " ], "offsets": [ [ 1029, 1123 ] ] }, { "id": "7195", "type": "abstract", "text": [ "In both HIV associated dementia in humans and its monkey model SIV encephalitis we find miR-21, a miRNA largely known for its link to oncogenesis, to be significantly upregulated in the brain. " ], "offsets": [ [ 1124, 1317 ] ] } ]

[ { "id": "7196", "type": "Specific_miRNAs", "text": [ "MiR-21" ], "offsets": [ [ 0, 6 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d154.s0.e0" } ] }, { "id": "7197", "type": "Diseases", "text": [ "neurodegenerative diseases" ], "offsets": [ [ 140, 166 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d154.s0.e1" } ] }, { "id": "7198", "type": "Specific_miRNAs", "text": [ "miR-21" ], "offsets": [ [ 185, 191 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d154.s1.e0" } ] }, { "id": "7199", "type": "Species", "text": [ "human" ], "offsets": [ [ 197, 202 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d154.s1.e1" } ] }, { "id": "7200", "type": "Relation_Trigger", "text": [ "specifically targets" ], "offsets": [ [ 287, 307 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d154.s2.e0" } ] }, { "id": "7201", "type": "Relation_Trigger", "text": [ "reduces its expression" ], "offsets": [ [ 414, 436 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d154.s2.e1" } ] }, { "id": "7202", "type": "Genes/Proteins", "text": [ "myocyte enhancer factor 2C" ], "offsets": [ [ 320, 346 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d154.s2.e2" } ] }, { "id": "7203", "type": "Genes/Proteins", "text": [ "MEF2C" ], "offsets": [ [ 348, 353 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d154.s2.e3" } ] }, { "id": "7204", "type": "Specific_miRNAs", "text": [ "miR-21" ], "offsets": [ [ 280, 286 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d154.s2.e4" } ] }, { "id": "7205", "type": "Diseases", "text": [ "dementia" ], "offsets": [ [ 504, 512 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d154.s3.e0" } ] }, { "id": "7206", "type": "Relation_Trigger", "text": [ "downregulated" ], "offsets": [ [ 461, 474 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d154.s3.e1" } ] }, { "id": "7207", "type": "Genes/Proteins", "text": [ "MEF2C" ], "offsets": [ [ 439, 444 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d154.s3.e2" } ] }, { "id": "7208", "type": "Species", "text": [ "patients" ], "offsets": [ [ 513, 521 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d154.s3.e3" } ] }, { "id": "7209", "type": "Specific_miRNAs", "text": [ "miR-21" ], "offsets": [ [ 602, 608 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d154.s4.e0" } ] }, { "id": "7210", "type": "Diseases", "text": [ "neurological disease" ], "offsets": [ [ 660, 680 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d154.s4.e1" } ] }, { "id": "7211", "type": "Diseases", "text": [ "HIV induced neuronal dysfunction" ], "offsets": [ [ 715, 747 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d154.s4.e2" } ] }, { "id": "7212", "type": "Non-Specific_miRNAs", "text": [ "MicroRNAs" ], "offsets": [ [ 774, 783 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d154.s5.e0" } ] }, { "id": "7213", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 785, 791 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d154.s5.e1" } ] }, { "id": "7214", "type": "Relation_Trigger", "text": [ "regulating" ], "offsets": [ [ 817, 827 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d154.s5.e2" } ] }, { "id": "7215", "type": "Relation_Trigger", "text": [ "dysregulates the expression" ], "offsets": [ [ 929, 956 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d154.s6.e0" } ] }, { "id": "7216", "type": "Specific_miRNAs", "text": [ "MicroRNA-21" ], "offsets": [ [ 917, 928 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d154.s6.e1" } ] }, { "id": "7217", "type": "Genes/Proteins", "text": [ "MEF2C" ], "offsets": [ [ 960, 965 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d154.s6.e2" } ] }, { "id": "7218", "type": "Diseases", "text": [ "SIV/HIV neurological disease" ], "offsets": [ [ 997, 1025 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d154.s6.e3" } ] }, { "id": "7219", "type": "Species", "text": [ "human" ], "offsets": [ [ 991, 996 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d154.s6.e4" } ] }, { "id": "7220", "type": "Specific_miRNAs", "text": [ "miR-21" ], "offsets": [ [ 1104, 1110 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d154.s7.e0" } ] }, { "id": "7221", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1222, 1227 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d154.s8.e0" } ] }, { "id": "7222", "type": "Diseases", "text": [ "dementia" ], "offsets": [ [ 1147, 1155 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d154.s8.e1" } ] }, { "id": "7223", "type": "Diseases", "text": [ "encephalitis" ], "offsets": [ [ 1191, 1203 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d154.s8.e2" } ] }, { "id": "7224", "type": "Specific_miRNAs", "text": [ "miR-21" ], "offsets": [ [ 1212, 1218 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d154.s8.e3" } ] }, { "id": "7225", "type": "Relation_Trigger", "text": [ "upregulated" ], "offsets": [ [ 1291, 1302 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d154.s8.e4" } ] }, { "id": "7226", "type": "Relation_Trigger", "text": [ "associated" ], "offsets": [ [ 1136, 1146 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d154.s8.e5" } ] }, { "id": "7227", "type": "Species", "text": [ "humans" ], "offsets": [ [ 1159, 1165 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d154.s8.e6" } ] } ]

[]

[]

[ { "id": "7228", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d154.s0.e0", "arg2_id": "miRNA-corp.d154.s0.e1", "normalized": [] }, { "id": "7229", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d154.s2.e4", "arg2_id": "miRNA-corp.d154.s2.e2", "normalized": [] }, { "id": "7230", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d154.s2.e4", "arg2_id": "miRNA-corp.d154.s2.e3", "normalized": [] }, { "id": "7231", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d154.s4.e0", "arg2_id": "miRNA-corp.d154.s4.e1", "normalized": [] }, { "id": "7232", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d154.s4.e0", "arg2_id": "miRNA-corp.d154.s4.e2", "normalized": [] }, { "id": "7233", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d154.s6.e1", "arg2_id": "miRNA-corp.d154.s6.e2", "normalized": [] }, { "id": "7234", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d154.s6.e1", "arg2_id": "miRNA-corp.d154.s6.e3", "normalized": [] }, { "id": "7235", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d154.s8.e3", "arg2_id": "miRNA-corp.d154.s8.e1", "normalized": [] }, { "id": "7236", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d154.s8.e3", "arg2_id": "miRNA-corp.d154.s8.e2", "normalized": [] }, { "id": "7237", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d154.s8.e0", "arg2_id": "miRNA-corp.d154.s8.e1", "normalized": [] }, { "id": "7238", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d154.s8.e0", "arg2_id": "miRNA-corp.d154.s8.e2", "normalized": [] } ]

[ { "id": "7240", "type": "title", "text": [ "However, by examining pairs in which the significance of the correlation coefficients is modestly relaxed, negative correlations do tend to predict targets and positive correlations tend to predict physically proximate pairs. " ], "offsets": [ [ 0, 226 ] ] }, { "id": "7241", "type": "abstract", "text": [ "A subset of high correlation pairs were experimentally validated by over-expressing or suppressing a miRNA and measuring the correlated mRNAs. " ], "offsets": [ [ 227, 370 ] ] }, { "id": "7242", "type": "abstract", "text": [ "Most of these highest correlation pairs do not contain sufficiently complementary sequences to predict a target relationship; nor do they lie in physical proximity to each other. " ], "offsets": [ [ 371, 550 ] ] }, { "id": "7243", "type": "abstract", "text": [ "From these data sets, we inferred and validated a tumor suppression pathway linked to miR-181c. " ], "offsets": [ [ 551, 649 ] ] }, { "id": "7244", "type": "abstract", "text": [ "CONCLUSIONS/SIGNIFICANCE: Sufficient information exists within a set of tumor samples to detect endogenous correlations between miRNA and mRNA levels. " ], "offsets": [ [ 650, 801 ] ] }, { "id": "7245", "type": "abstract", "text": [ "Based on the validations the causal arrow for these correlations is likely to be directed from the miRNAs to the mRNAs. " ], "offsets": [ [ 802, 922 ] ] }, { "id": "7246", "type": "abstract", "text": [ "METHODOLOGY/PRINCIPAL FINDINGS: RNA was extracted from 12 human primary brain tumor biopsies. " ], "offsets": [ [ 923, 1017 ] ] }, { "id": "7247", "type": "abstract", "text": [ "These samples were used to determine genome-wide mRNA expression levels by microarray analysis and a miRNA profile by real-time reverse transcription PCR. " ], "offsets": [ [ 1018, 1173 ] ] }, { "id": "7248", "type": "abstract", "text": [ "Correlation coefficients were determined for all possible mRNA-miRNA pairs and the distribution of these correlations compared to the random distribution. " ], "offsets": [ [ 1174, 1329 ] ] }, { "id": "7249", "type": "abstract", "text": [ "An excess of high positive and negative correlation pairs were observed at the tails of these distributions. " ], "offsets": [ [ 1330, 1439 ] ] }, { "id": "7250", "type": "abstract", "text": [ "BACKGROUND: microRNAs (miRNAs) are approximately 21 nucleotide non-coding transcripts capable of regulating gene expression. " ], "offsets": [ [ 1440, 1565 ] ] }, { "id": "7251", "type": "abstract", "text": [ "Detection of a microRNA signal in an in vivo expression set of mRNAs. " ], "offsets": [ [ 1566, 1637 ] ] }, { "id": "7252", "type": "abstract", "text": [ "As a result, translation of the target mRNA is inhibited and the mRNA may be destabilized. " ], "offsets": [ [ 1638, 1729 ] ] }, { "id": "7253", "type": "abstract", "text": [ "The most widely studied mechanism of regulation involves binding of a miRNA to the target mRNA. " ], "offsets": [ [ 1730, 1826 ] ] }, { "id": "7254", "type": "abstract", "text": [ "We asked whether endogenous fluctuations in a set of mRNA and miRNA profiles contain correlated changes that are statistically distinguishable from the many other fluctuations in the data set. " ], "offsets": [ [ 1827, 2020 ] ] }, { "id": "7255", "type": "abstract", "text": [ "The inhibitory effects of miRNAs have been linked to diverse cellular processes including malignant proliferation, apoptosis, development, differentiation, and metabolic processes. " ], "offsets": [ [ 2021, 2202 ] ] } ]

[ { "id": "7256", "type": "Relation_Trigger", "text": [ "targets" ], "offsets": [ [ 148, 155 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d155.s0.e0" } ] }, { "id": "7257", "type": "Relation_Trigger", "text": [ "correlation" ], "offsets": [ [ 61, 72 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d155.s0.e1" } ] }, { "id": "7258", "type": "Relation_Trigger", "text": [ "negative correlations" ], "offsets": [ [ 107, 128 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d155.s0.e2" } ] }, { "id": "7259", "type": "Relation_Trigger", "text": [ "positive correlations" ], "offsets": [ [ 160, 181 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d155.s0.e3" } ] }, { "id": "7260", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 328, 333 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d155.s1.e0" } ] }, { "id": "7261", "type": "Relation_Trigger", "text": [ "high correlation" ], "offsets": [ [ 239, 255 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d155.s1.e1" } ] }, { "id": "7262", "type": "Relation_Trigger", "text": [ "over-expressing" ], "offsets": [ [ 295, 310 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d155.s1.e2" } ] }, { "id": "7263", "type": "Relation_Trigger", "text": [ "suppressing" ], "offsets": [ [ 314, 325 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d155.s1.e3" } ] }, { "id": "7264", "type": "Relation_Trigger", "text": [ "correlated" ], "offsets": [ [ 352, 362 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d155.s1.e4" } ] }, { "id": "7265", "type": "Relation_Trigger", "text": [ "highest correlation" ], "offsets": [ [ 385, 404 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d155.s2.e0" } ] }, { "id": "7266", "type": "Relation_Trigger", "text": [ "target" ], "offsets": [ [ 476, 482 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d155.s2.e1" } ] }, { "id": "7267", "type": "Specific_miRNAs", "text": [ "miR-181c" ], "offsets": [ [ 637, 645 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d155.s3.e0" } ] }, { "id": "7268", "type": "Relation_Trigger", "text": [ "suppression" ], "offsets": [ [ 607, 618 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d155.s3.e1" } ] }, { "id": "7269", "type": "Diseases", "text": [ "tumor" ], "offsets": [ [ 601, 606 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d155.s3.e2" } ] }, { "id": "7270", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 778, 783 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d155.s4.e0" } ] }, { "id": "7271", "type": "Relation_Trigger", "text": [ "correlations" ], "offsets": [ [ 757, 769 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d155.s4.e1" } ] }, { "id": "7272", "type": "Diseases", "text": [ "tumor" ], "offsets": [ [ 722, 727 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d155.s4.e2" } ] }, { "id": "7273", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 901, 907 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d155.s5.e0" } ] }, { "id": "7274", "type": "Relation_Trigger", "text": [ "correlations" ], "offsets": [ [ 854, 866 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d155.s5.e1" } ] }, { "id": "7275", "type": "Diseases", "text": [ "primary brain tumor" ], "offsets": [ [ 987, 1006 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d155.s6.e0" } ] }, { "id": "7276", "type": "Species", "text": [ "human" ], "offsets": [ [ 981, 986 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d155.s6.e1" } ] }, { "id": "7277", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1119, 1124 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d155.s7.e0" } ] }, { "id": "7278", "type": "Relation_Trigger", "text": [ "Correlation" ], "offsets": [ [ 1174, 1185 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d155.s8.e0" } ] }, { "id": "7279", "type": "Relation_Trigger", "text": [ "correlations" ], "offsets": [ [ 1279, 1291 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d155.s8.e1" } ] }, { "id": "7280", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1237, 1242 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d155.s8.e2" } ] }, { "id": "7281", "type": "Relation_Trigger", "text": [ "negative correlation" ], "offsets": [ [ 1361, 1381 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d155.s9.e0" } ] }, { "id": "7282", "type": "Non-Specific_miRNAs", "text": [ "microRNAs" ], "offsets": [ [ 1452, 1461 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d155.s10.e0" } ] }, { "id": "7283", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1463, 1469 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d155.s10.e1" } ] }, { "id": "7284", "type": "Relation_Trigger", "text": [ "regulating gene expression" ], "offsets": [ [ 1537, 1563 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d155.s10.e2" } ] }, { "id": "7285", "type": "Non-Specific_miRNAs", "text": [ "microRNA" ], "offsets": [ [ 1581, 1589 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d155.s11.e0" } ] }, { "id": "7286", "type": "Relation_Trigger", "text": [ "target" ], "offsets": [ [ 1670, 1676 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d155.s12.e0" } ] }, { "id": "7287", "type": "Relation_Trigger", "text": [ "inhibited" ], "offsets": [ [ 1685, 1694 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d155.s12.e1" } ] }, { "id": "7288", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1800, 1805 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d155.s13.e0" } ] }, { "id": "7289", "type": "Relation_Trigger", "text": [ "target" ], "offsets": [ [ 1813, 1819 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d155.s13.e1" } ] }, { "id": "7290", "type": "Relation_Trigger", "text": [ "regulation" ], "offsets": [ [ 1767, 1777 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d155.s13.e2" } ] }, { "id": "7291", "type": "Relation_Trigger", "text": [ "binding" ], "offsets": [ [ 1787, 1794 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d155.s13.e3" } ] }, { "id": "7292", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1889, 1894 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d155.s14.e0" } ] }, { "id": "7293", "type": "Relation_Trigger", "text": [ "correlated" ], "offsets": [ [ 1912, 1922 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d155.s14.e1" } ] }, { "id": "7294", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 2047, 2053 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d155.s15.e0" } ] }, { "id": "7295", "type": "Relation_Trigger", "text": [ "inhibitory effects" ], "offsets": [ [ 2025, 2043 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d155.s15.e1" } ] } ]

[]

[]

[ { "id": "7296", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d155.s3.e0", "arg2_id": "miRNA-corp.d155.s3.e2", "normalized": [] }, { "id": "7297", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d155.s4.e0", "arg2_id": "miRNA-corp.d155.s4.e2", "normalized": [] } ]

[ { "id": "7299", "type": "title", "text": [ "A novel microRNA and transcription factor mediated regulatory network in schizophrenia. " ], "offsets": [ [ 0, 89 ] ] }, { "id": "7300", "type": "abstract", "text": [ "Previous studies have suggested that changes in gene expression may play an important role in the etiology of schizophrenia, and that microRNAs (miRNAs) and transcription factors (TFs) are primary regulators of this gene expression. " ], "offsets": [ [ 90, 323 ] ] }, { "id": "7301", "type": "abstract", "text": [ "BACKGROUND: Schizophrenia is a complex brain disorder with molecular mechanisms that have yet to be elucidated. " ], "offsets": [ [ 324, 436 ] ] }, { "id": "7302", "type": "abstract", "text": [ "We hypothesized that miRNAs and TFs might play combinatory regulatory roles for schizophrenia genes and, thus, explored miRNA-TF regulatory networks in schizophrenia. " ], "offsets": [ [ 437, 604 ] ] }, { "id": "7303", "type": "abstract", "text": [ "So far, several miRNA-TF mediated regulatory modules have been verified. " ], "offsets": [ [ 605, 678 ] ] }, { "id": "7304", "type": "abstract", "text": [ "Our evaluation revealed that these observed FFLs were significantly enriched in schizophrenia genes. " ], "offsets": [ [ 679, 780 ] ] }, { "id": "7305", "type": "abstract", "text": [ "RESULTS: We identified 32 feed-forward loops (FFLs) among our compiled schizophrenia-related miRNAs, TFs and genes. " ], "offsets": [ [ 781, 897 ] ] }, { "id": "7306", "type": "abstract", "text": [ "By converging the FFLs and mutual feedback loops, we constructed a novel miRNA-TF regulatory network for schizophrenia. " ], "offsets": [ [ 898, 1018 ] ] }, { "id": "7307", "type": "abstract", "text": [ "Our analysis revealed EGR3 and hsa-miR-195 were core regulators in this regulatory network. " ], "offsets": [ [ 1019, 1111 ] ] }, { "id": "7308", "type": "abstract", "text": [ "We next proposed a model highlighting EGR3 and miRNAs involved in signaling pathways and regulatory networks in the nervous system. " ], "offsets": [ [ 1112, 1244 ] ] }, { "id": "7309", "type": "abstract", "text": [ "It represents the first investigation of a miRNA-TF regulatory network for a complex disease, as demonstrated in schizophrenia. " ], "offsets": [ [ 1245, 1375 ] ] }, { "id": "7310", "type": "abstract", "text": [ "CONCLUSIONS: This study provides many insights on the regulatory mechanisms of genes involved in schizophrenia. " ], "offsets": [ [ 1376, 1488 ] ] }, { "id": "7311", "type": "abstract", "text": [ "Finally, we suggested several single nucleotide polymorphisms (SNPs) located on miRNAs, their target sites, and TFBSs, which may have an effect in schizophrenia gene regulation. " ], "offsets": [ [ 1489, 1667 ] ] } ]

[ { "id": "7312", "type": "Non-Specific_miRNAs", "text": [ "microRNA" ], "offsets": [ [ 8, 16 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d156.s0.e0" } ] }, { "id": "7313", "type": "Diseases", "text": [ "schizophrenia" ], "offsets": [ [ 73, 86 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d156.s0.e1" } ] }, { "id": "7314", "type": "Relation_Trigger", "text": [ "regulatory" ], "offsets": [ [ 51, 61 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d156.s0.e2" } ] }, { "id": "7315", "type": "Non-Specific_miRNAs", "text": [ "microRNAs" ], "offsets": [ [ 224, 233 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d156.s1.e0" } ] }, { "id": "7316", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 235, 241 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d156.s1.e1" } ] }, { "id": "7317", "type": "Diseases", "text": [ "schizophrenia" ], "offsets": [ [ 200, 213 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d156.s1.e2" } ] }, { "id": "7318", "type": "Relation_Trigger", "text": [ "regulators of this gene expression" ], "offsets": [ [ 287, 321 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d156.s1.e3" } ] }, { "id": "7319", "type": "Relation_Trigger", "text": [ "changes in gene expression" ], "offsets": [ [ 127, 153 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d156.s1.e4" } ] }, { "id": "7320", "type": "Diseases", "text": [ "Schizophrenia" ], "offsets": [ [ 336, 349 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d156.s2.e0" } ] }, { "id": "7321", "type": "Diseases", "text": [ "brain disorder" ], "offsets": [ [ 363, 377 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d156.s2.e1" } ] }, { "id": "7322", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 458, 464 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d156.s3.e0" } ] }, { "id": "7323", "type": "Diseases", "text": [ "schizophrenia" ], "offsets": [ [ 517, 530 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d156.s3.e1" } ] }, { "id": "7324", "type": "Diseases", "text": [ "schizophrenia" ], "offsets": [ [ 589, 602 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d156.s3.e2" } ] }, { "id": "7325", "type": "Relation_Trigger", "text": [ "regulatory" ], "offsets": [ [ 566, 576 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d156.s3.e3" } ] }, { "id": "7326", "type": "Relation_Trigger", "text": [ "regulatory" ], "offsets": [ [ 496, 506 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d156.s3.e4" } ] }, { "id": "7327", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 557, 562 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d156.s3.e5" } ] }, { "id": "7328", "type": "Relation_Trigger", "text": [ "regulatory" ], "offsets": [ [ 639, 649 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d156.s4.e0" } ] }, { "id": "7329", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 621, 626 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d156.s4.e1" } ] }, { "id": "7330", "type": "Diseases", "text": [ "schizophrenia" ], "offsets": [ [ 759, 772 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d156.s5.e0" } ] }, { "id": "7331", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 874, 880 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d156.s6.e0" } ] }, { "id": "7332", "type": "Diseases", "text": [ "schizophrenia" ], "offsets": [ [ 852, 865 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d156.s6.e1" } ] }, { "id": "7333", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 971, 976 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d156.s7.e0" } ] }, { "id": "7334", "type": "Diseases", "text": [ "schizophrenia" ], "offsets": [ [ 1003, 1016 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d156.s7.e1" } ] }, { "id": "7335", "type": "Relation_Trigger", "text": [ "regulatory" ], "offsets": [ [ 980, 990 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d156.s7.e2" } ] }, { "id": "7336", "type": "Specific_miRNAs", "text": [ "hsa-miR-195" ], "offsets": [ [ 1050, 1061 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d156.s8.e0" } ] }, { "id": "7337", "type": "Genes/Proteins", "text": [ "EGR3" ], "offsets": [ [ 1041, 1045 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d156.s8.e1" } ] }, { "id": "7338", "type": "Relation_Trigger", "text": [ "core regulators" ], "offsets": [ [ 1067, 1082 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d156.s8.e2" } ] }, { "id": "7339", "type": "Relation_Trigger", "text": [ "regulatory" ], "offsets": [ [ 1091, 1101 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d156.s8.e3" } ] }, { "id": "7340", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1159, 1165 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d156.s9.e0" } ] }, { "id": "7341", "type": "Genes/Proteins", "text": [ "EGR3" ], "offsets": [ [ 1150, 1154 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d156.s9.e1" } ] }, { "id": "7342", "type": "Relation_Trigger", "text": [ "regulatory" ], "offsets": [ [ 1201, 1211 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d156.s9.e2" } ] }, { "id": "7343", "type": "Diseases", "text": [ "schizophrenia" ], "offsets": [ [ 1358, 1371 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d156.s10.e0" } ] }, { "id": "7344", "type": "Relation_Trigger", "text": [ "regulatory" ], "offsets": [ [ 1297, 1307 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d156.s10.e1" } ] }, { "id": "7345", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1288, 1293 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d156.s10.e2" } ] }, { "id": "7346", "type": "Diseases", "text": [ "schizophrenia" ], "offsets": [ [ 1473, 1486 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d156.s11.e0" } ] }, { "id": "7347", "type": "Relation_Trigger", "text": [ "regulatory" ], "offsets": [ [ 1430, 1440 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d156.s11.e1" } ] }, { "id": "7348", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1569, 1575 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d156.s12.e0" } ] }, { "id": "7349", "type": "Diseases", "text": [ "schizophrenia" ], "offsets": [ [ 1636, 1649 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d156.s12.e1" } ] }, { "id": "7350", "type": "Relation_Trigger", "text": [ "regulation" ], "offsets": [ [ 1655, 1665 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d156.s12.e2" } ] }, { "id": "7351", "type": "Relation_Trigger", "text": [ "target" ], "offsets": [ [ 1583, 1589 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d156.s12.e3" } ] } ]

[]

[]

[ { "id": "7352", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d156.s0.e0", "arg2_id": "miRNA-corp.d156.s0.e1", "normalized": [] }, { "id": "7353", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d156.s1.e0", "arg2_id": "miRNA-corp.d156.s1.e2", "normalized": [] }, { "id": "7354", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d156.s1.e1", "arg2_id": "miRNA-corp.d156.s1.e2", "normalized": [] }, { "id": "7355", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d156.s3.e0", "arg2_id": "miRNA-corp.d156.s3.e1", "normalized": [] }, { "id": "7356", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d156.s3.e0", "arg2_id": "miRNA-corp.d156.s3.e2", "normalized": [] }, { "id": "7357", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d156.s3.e5", "arg2_id": "miRNA-corp.d156.s3.e1", "normalized": [] }, { "id": "7358", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d156.s3.e5", "arg2_id": "miRNA-corp.d156.s3.e2", "normalized": [] }, { "id": "7359", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d156.s6.e0", "arg2_id": "miRNA-corp.d156.s6.e1", "normalized": [] }, { "id": "7360", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d156.s7.e0", "arg2_id": "miRNA-corp.d156.s7.e1", "normalized": [] }, { "id": "7361", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d156.s8.e0", "arg2_id": "miRNA-corp.d156.s8.e1", "normalized": [] }, { "id": "7362", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d156.s9.e0", "arg2_id": "miRNA-corp.d156.s9.e1", "normalized": [] }, { "id": "7363", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d156.s10.e2", "arg2_id": "miRNA-corp.d156.s10.e0", "normalized": [] }, { "id": "7364", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d156.s12.e0", "arg2_id": "miRNA-corp.d156.s12.e1", "normalized": [] } ]

[ { "id": "7366", "type": "title", "text": [ "METHODOLOGY/PRINCIPAL FINDINGS: In a screening of MB cell lines, the miRNA miR-199b-5p was seen to be a regulator of the Notch pathway through its targeting of the transcription factor HES1. Down-regulation of HES1 expression by miR-199b-5p negatively regulates the proliferation rate and anchorage-independent growth of MB cells. " ], "offsets": [ [ 0, 331 ] ] }, { "id": "7367", "type": "abstract", "text": [ "MiR-199b-5p over-expression blocks expression of several cancer stem-cell genes, impairs the engrafting potential of MB cells in the cerebellum of athymic/nude mice, and of particular interest, decreases the MB stem-cell-like (CD133+) subpopulation of cells. " ], "offsets": [ [ 332, 591 ] ] }, { "id": "7368", "type": "abstract", "text": [ "In our analysis of 61 patients with MB, the expression of miR-199b-5p in the non-metastatic cases was significantly higher than in the metastatic cases (P = 0.001). " ], "offsets": [ [ 592, 757 ] ] }, { "id": "7369", "type": "abstract", "text": [ "Correlation with survival for these patients with high levels of miR-199b expression showed a positive trend to better overall survival than for the low-expressing patients. " ], "offsets": [ [ 758, 932 ] ] }, { "id": "7370", "type": "abstract", "text": [ "Here we have investigated medulloblastoma tumors (MBs), which arise from an early impairment of developmental processes in the cerebellum, where Notch signaling is involved in many cell-fate-determining stages. " ], "offsets": [ [ 933, 1144 ] ] }, { "id": "7371", "type": "abstract", "text": [ "MBs occur bimodally, with the peak incidence seen between 3-4 years and 8-9 years of age, although it can also occur in adults. " ], "offsets": [ [ 1145, 1273 ] ] }, { "id": "7372", "type": "abstract", "text": [ "Notch regulates a subset of the MB cells that have stem-cell-like properties and can promote tumor growth. " ], "offsets": [ [ 1274, 1381 ] ] }, { "id": "7373", "type": "abstract", "text": [ "On the basis of this evidence, we hypothesized that miRNAs targeting the Notch pathway can regulated these phenomena, and can be used in anti-cancer therapies. " ], "offsets": [ [ 1382, 1542 ] ] }, { "id": "7374", "type": "abstract", "text": [ "BACKGROUND: Through negative regulation of gene expression, microRNAs (miRNAs) can function in cancers as oncosuppressors, and they can show altered expression in various tumor types. " ], "offsets": [ [ 1543, 1727 ] ] }, { "id": "7375", "type": "abstract", "text": [ "MicroRNA-199b-5p impairs cancer stem cells through negative regulation of HES1 in medulloblastoma. " ], "offsets": [ [ 1728, 1828 ] ] }, { "id": "7376", "type": "abstract", "text": [ "To date, this is the first report that expression of a miRNA can deplete the tumor stem cells, indicating an interesting therapeutic approach for the targeting of these cells in brain tumors. " ], "offsets": [ [ 1829, 2023 ] ] }, { "id": "7377", "type": "abstract", "text": [ "CONCLUSIONS/SIGNIFICANCE: Despite advances in our understanding of the pathogenesis of MB, one-third of these patients remain incurable and current treatments can significantly damage long-term survivors. " ], "offsets": [ [ 2024, 2229 ] ] }, { "id": "7378", "type": "abstract", "text": [ "Infection with MB cells in an induced xenograft model in the mouse cerebellum and the use of an adenovirus carrying miR-199b-5p indicate a clinical benefit through this negative influence of miR-199b-5p on tumor growth and on the subset of MB stem-cell-like cells, providing further proof of concept. " ], "offsets": [ [ 2230, 2531 ] ] }, { "id": "7379", "type": "abstract", "text": [ "We further show that in a xenograft model, MB tumor burden can be reduced, indicating the use of miR199b-5p as an adjuvant therapy after surgery, in combination with radiation and chemotherapy, for the improvement of anti-cancer MB therapies and patient quality of life. " ], "offsets": [ [ 2532, 2803 ] ] }, { "id": "7380", "type": "abstract", "text": [ "Here we show that miR-199b-5p expression correlates with metastasis spread, identifying a new molecular marker for a poor-risk class in patients with MB. " ], "offsets": [ [ 2804, 2958 ] ] }, { "id": "7381", "type": "abstract", "text": [ "These data showing the down-regulation of miR-199b-5p in metastatic MBs suggest a potential silencing mechanism through epigenetic or genetic alterations. " ], "offsets": [ [ 2959, 3114 ] ] }, { "id": "7382", "type": "abstract", "text": [ "Furthermore, two cell lines (Med8a and UW228) showed significant up-regulation of miR-199b-5p upon treatment. " ], "offsets": [ [ 3115, 3225 ] ] }, { "id": "7383", "type": "abstract", "text": [ "Upon induction of de-methylation using 5-aza-deoxycytidine, lower miR-199b-5p expression was seen in a panel of MB cell lines, supported an epigenetic mechanism of regulation. " ], "offsets": [ [ 3226, 3402 ] ] } ]

[ { "id": "7384", "type": "Genes/Proteins", "text": [ "HES1" ], "offsets": [ [ 185, 189 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s0.e0" } ] }, { "id": "7385", "type": "Specific_miRNAs", "text": [ "miR-199b-5p" ], "offsets": [ [ 75, 86 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s0.e1" } ] }, { "id": "7386", "type": "Genes/Proteins", "text": [ "HES1" ], "offsets": [ [ 210, 214 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s0.e2" } ] }, { "id": "7387", "type": "Specific_miRNAs", "text": [ "miR-199b-5p" ], "offsets": [ [ 229, 240 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s0.e3" } ] }, { "id": "7388", "type": "Diseases", "text": [ "MB" ], "offsets": [ [ 321, 323 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s0.e4" } ] }, { "id": "7389", "type": "Relation_Trigger", "text": [ "targeting" ], "offsets": [ [ 147, 156 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s0.e5" } ] }, { "id": "7390", "type": "Relation_Trigger", "text": [ "negatively regulates" ], "offsets": [ [ 241, 261 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s0.e6" } ] }, { "id": "7391", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 69, 74 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s0.e7" } ] }, { "id": "7392", "type": "Relation_Trigger", "text": [ "regulator" ], "offsets": [ [ 104, 113 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s0.e8" } ] }, { "id": "7393", "type": "Relation_Trigger", "text": [ "Down-regulation of HES1 expression" ], "offsets": [ [ 191, 225 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s0.e9" } ] }, { "id": "7394", "type": "Specific_miRNAs", "text": [ "MiR-199b-5p" ], "offsets": [ [ 332, 343 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s1.e0" } ] }, { "id": "7395", "type": "Relation_Trigger", "text": [ "blocks expression" ], "offsets": [ [ 360, 377 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s1.e1" } ] }, { "id": "7396", "type": "Diseases", "text": [ "MB" ], "offsets": [ [ 449, 451 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s1.e2" } ] }, { "id": "7397", "type": "Relation_Trigger", "text": [ "over-expression" ], "offsets": [ [ 344, 359 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s1.e3" } ] }, { "id": "7398", "type": "Relation_Trigger", "text": [ "impairs" ], "offsets": [ [ 413, 420 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s1.e4" } ] }, { "id": "7399", "type": "Diseases", "text": [ "MB" ], "offsets": [ [ 540, 542 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s1.e5" } ] }, { "id": "7400", "type": "Diseases", "text": [ "cancer" ], "offsets": [ [ 389, 395 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s1.e6" } ] }, { "id": "7401", "type": "Species", "text": [ "nude mice" ], "offsets": [ [ 487, 496 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s1.e7" } ] }, { "id": "7402", "type": "Diseases", "text": [ "MB" ], "offsets": [ [ 628, 630 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s2.e0" } ] }, { "id": "7403", "type": "Specific_miRNAs", "text": [ "miR-199b-5p" ], "offsets": [ [ 650, 661 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s2.e1" } ] }, { "id": "7404", "type": "Relation_Trigger", "text": [ "expression of miR-199b-5p in the non-metastatic cases was significantly higher" ], "offsets": [ [ 636, 714 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s2.e2" } ] }, { "id": "7405", "type": "Species", "text": [ "patients" ], "offsets": [ [ 614, 622 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s2.e3" } ] }, { "id": "7406", "type": "Specific_miRNAs", "text": [ "miR-199b" ], "offsets": [ [ 823, 831 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s3.e0" } ] }, { "id": "7407", "type": "Relation_Trigger", "text": [ "Correlation" ], "offsets": [ [ 758, 769 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s3.e1" } ] }, { "id": "7408", "type": "Relation_Trigger", "text": [ "high levels of miR-199b expression" ], "offsets": [ [ 808, 842 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s3.e2" } ] }, { "id": "7409", "type": "Species", "text": [ "patients" ], "offsets": [ [ 794, 802 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s3.e3" } ] }, { "id": "7410", "type": "Species", "text": [ "patients" ], "offsets": [ [ 922, 930 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s3.e4" } ] }, { "id": "7411", "type": "Diseases", "text": [ "medulloblastoma tumors" ], "offsets": [ [ 959, 981 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s4.e0" } ] }, { "id": "7412", "type": "Diseases", "text": [ "MBs" ], "offsets": [ [ 983, 986 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s4.e1" } ] }, { "id": "7413", "type": "Relation_Trigger", "text": [ "impairment" ], "offsets": [ [ 1015, 1025 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s4.e2" } ] }, { "id": "7414", "type": "Diseases", "text": [ "tumors" ], "offsets": [ [ 975, 981 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s4.e3" } ] }, { "id": "7415", "type": "Diseases", "text": [ "MBs" ], "offsets": [ [ 1145, 1148 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s5.e0" } ] }, { "id": "7416", "type": "Diseases", "text": [ "MB" ], "offsets": [ [ 1306, 1308 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s6.e0" } ] }, { "id": "7417", "type": "Relation_Trigger", "text": [ "regulates" ], "offsets": [ [ 1280, 1289 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s6.e1" } ] }, { "id": "7418", "type": "Diseases", "text": [ "tumor" ], "offsets": [ [ 1367, 1372 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s6.e2" } ] }, { "id": "7419", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1434, 1440 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s7.e0" } ] }, { "id": "7420", "type": "Relation_Trigger", "text": [ "targeting" ], "offsets": [ [ 1441, 1450 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s7.e1" } ] }, { "id": "7421", "type": "Relation_Trigger", "text": [ "regulated" ], "offsets": [ [ 1473, 1482 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s7.e2" } ] }, { "id": "7422", "type": "Non-Specific_miRNAs", "text": [ "microRNAs" ], "offsets": [ [ 1603, 1612 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s8.e0" } ] }, { "id": "7423", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1614, 1620 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s8.e1" } ] }, { "id": "7424", "type": "Relation_Trigger", "text": [ "regulation of gene expression" ], "offsets": [ [ 1572, 1601 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s8.e2" } ] }, { "id": "7425", "type": "Relation_Trigger", "text": [ "negative regulation" ], "offsets": [ [ 1563, 1582 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s8.e3" } ] }, { "id": "7426", "type": "Relation_Trigger", "text": [ "oncosuppressors" ], "offsets": [ [ 1649, 1664 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s8.e4" } ] }, { "id": "7427", "type": "Relation_Trigger", "text": [ "altered expression" ], "offsets": [ [ 1684, 1702 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s8.e5" } ] }, { "id": "7428", "type": "Diseases", "text": [ "cancers" ], "offsets": [ [ 1638, 1645 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s8.e6" } ] }, { "id": "7429", "type": "Diseases", "text": [ "tumor" ], "offsets": [ [ 1714, 1719 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s8.e7" } ] }, { "id": "7430", "type": "Specific_miRNAs", "text": [ "MicroRNA-199b-5p" ], "offsets": [ [ 1728, 1744 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s9.e0" } ] }, { "id": "7431", "type": "Genes/Proteins", "text": [ "HES1" ], "offsets": [ [ 1802, 1806 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s9.e1" } ] }, { "id": "7432", "type": "Diseases", "text": [ "medulloblastoma" ], "offsets": [ [ 1810, 1825 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s9.e2" } ] }, { "id": "7433", "type": "Relation_Trigger", "text": [ "impairs" ], "offsets": [ [ 1745, 1752 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s9.e3" } ] }, { "id": "7434", "type": "Relation_Trigger", "text": [ "negative regulation" ], "offsets": [ [ 1779, 1798 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s9.e4" } ] }, { "id": "7435", "type": "Diseases", "text": [ "cancer" ], "offsets": [ [ 1753, 1759 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s9.e5" } ] }, { "id": "7436", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1884, 1889 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s10.e0" } ] }, { "id": "7437", "type": "Diseases", "text": [ "brain tumors" ], "offsets": [ [ 2007, 2019 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s10.e1" } ] }, { "id": "7438", "type": "Diseases", "text": [ "tumor" ], "offsets": [ [ 1906, 1911 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s10.e2" } ] }, { "id": "7439", "type": "Relation_Trigger", "text": [ "targeting" ], "offsets": [ [ 1979, 1988 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s10.e3" } ] }, { "id": "7440", "type": "Diseases", "text": [ "MB" ], "offsets": [ [ 2111, 2113 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s11.e0" } ] }, { "id": "7441", "type": "Species", "text": [ "patients" ], "offsets": [ [ 2134, 2142 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s11.e1" } ] }, { "id": "7442", "type": "Specific_miRNAs", "text": [ "miR-199b-5p" ], "offsets": [ [ 2346, 2357 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s12.e0" } ] }, { "id": "7443", "type": "Specific_miRNAs", "text": [ "miR-199b-5p" ], "offsets": [ [ 2421, 2432 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s12.e1" } ] }, { "id": "7444", "type": "Diseases", "text": [ "MB" ], "offsets": [ [ 2470, 2472 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s12.e2" } ] }, { "id": "7445", "type": "Diseases", "text": [ "Infection" ], "offsets": [ [ 2230, 2239 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s12.e3" } ] }, { "id": "7446", "type": "Diseases", "text": [ "MB" ], "offsets": [ [ 2245, 2247 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s12.e4" } ] }, { "id": "7447", "type": "Diseases", "text": [ "tumor" ], "offsets": [ [ 2436, 2441 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s12.e5" } ] }, { "id": "7448", "type": "Species", "text": [ "mouse" ], "offsets": [ [ 2291, 2296 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s12.e6" } ] }, { "id": "7449", "type": "Specific_miRNAs", "text": [ "miR199b-5p" ], "offsets": [ [ 2629, 2639 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s13.e0" } ] }, { "id": "7450", "type": "Diseases", "text": [ "MB" ], "offsets": [ [ 2761, 2763 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s13.e1" } ] }, { "id": "7451", "type": "Diseases", "text": [ "MB tumor" ], "offsets": [ [ 2575, 2583 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s13.e2" } ] }, { "id": "7452", "type": "Diseases", "text": [ "tumor" ], "offsets": [ [ 2578, 2583 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s13.e3" } ] }, { "id": "7453", "type": "Species", "text": [ "patient" ], "offsets": [ [ 2778, 2785 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s13.e4" } ] }, { "id": "7454", "type": "Specific_miRNAs", "text": [ "miR-199b-5p" ], "offsets": [ [ 2822, 2833 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s14.e0" } ] }, { "id": "7455", "type": "Diseases", "text": [ "MB" ], "offsets": [ [ 2954, 2956 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s14.e1" } ] }, { "id": "7456", "type": "Relation_Trigger", "text": [ "expression correlates" ], "offsets": [ [ 2834, 2855 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s14.e2" } ] }, { "id": "7457", "type": "Species", "text": [ "patients" ], "offsets": [ [ 2940, 2948 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s14.e3" } ] }, { "id": "7458", "type": "Specific_miRNAs", "text": [ "miR-199b-5p" ], "offsets": [ [ 3001, 3012 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s15.e0" } ] }, { "id": "7459", "type": "Diseases", "text": [ "MBs" ], "offsets": [ [ 3027, 3030 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s15.e1" } ] }, { "id": "7460", "type": "Relation_Trigger", "text": [ "down-regulation" ], "offsets": [ [ 2982, 2997 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s15.e2" } ] }, { "id": "7461", "type": "Specific_miRNAs", "text": [ "miR-199b-5p" ], "offsets": [ [ 3197, 3208 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s16.e0" } ] }, { "id": "7462", "type": "Relation_Trigger", "text": [ "up-regulation" ], "offsets": [ [ 3180, 3193 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s16.e1" } ] }, { "id": "7463", "type": "Specific_miRNAs", "text": [ "miR-199b-5p" ], "offsets": [ [ 3292, 3303 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s17.e0" } ] }, { "id": "7464", "type": "Relation_Trigger", "text": [ "lower miR-199b-5p expression" ], "offsets": [ [ 3286, 3314 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s17.e1" } ] }, { "id": "7465", "type": "Relation_Trigger", "text": [ "regulation" ], "offsets": [ [ 3390, 3400 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d157.s17.e2" } ] } ]

[]

[]

[ { "id": "7466", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d157.s0.e3", "arg2_id": "miRNA-corp.d157.s0.e4", "normalized": [] }, { "id": "7467", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d157.s0.e3", "arg2_id": "miRNA-corp.d157.s0.e0", "normalized": [] }, { "id": "7468", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d157.s0.e3", "arg2_id": "miRNA-corp.d157.s0.e2", "normalized": [] }, { "id": "7469", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d157.s0.e7", "arg2_id": "miRNA-corp.d157.s0.e4", "normalized": [] }, { "id": "7470", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d157.s0.e7", "arg2_id": "miRNA-corp.d157.s0.e0", "normalized": [] }, { "id": "7471", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d157.s0.e7", "arg2_id": "miRNA-corp.d157.s0.e2", "normalized": [] }, { "id": "7472", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d157.s0.e1", "arg2_id": "miRNA-corp.d157.s0.e4", "normalized": [] }, { "id": "7473", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d157.s0.e1", "arg2_id": "miRNA-corp.d157.s0.e0", "normalized": [] }, { "id": "7474", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d157.s0.e1", "arg2_id": "miRNA-corp.d157.s0.e2", "normalized": [] }, { "id": "7475", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d157.s1.e0", "arg2_id": "miRNA-corp.d157.s1.e2", "normalized": [] }, { "id": "7476", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d157.s1.e0", "arg2_id": "miRNA-corp.d157.s1.e5", "normalized": [] }, { "id": "7477", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d157.s1.e0", "arg2_id": "miRNA-corp.d157.s1.e6", "normalized": [] }, { "id": "7478", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d157.s2.e1", "arg2_id": "miRNA-corp.d157.s2.e0", "normalized": [] }, { "id": "7479", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d157.s8.e0", "arg2_id": "miRNA-corp.d157.s8.e6", "normalized": [] }, { "id": "7480", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d157.s8.e0", "arg2_id": "miRNA-corp.d157.s8.e7", "normalized": [] }, { "id": "7481", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d157.s8.e1", "arg2_id": "miRNA-corp.d157.s8.e6", "normalized": [] }, { "id": "7482", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d157.s8.e1", "arg2_id": "miRNA-corp.d157.s8.e7", "normalized": [] }, { "id": "7483", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d157.s9.e0", "arg2_id": "miRNA-corp.d157.s9.e1", "normalized": [] }, { "id": "7484", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d157.s9.e0", "arg2_id": "miRNA-corp.d157.s9.e2", "normalized": [] }, { "id": "7485", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d157.s9.e0", "arg2_id": "miRNA-corp.d157.s9.e5", "normalized": [] }, { "id": "7486", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d157.s10.e0", "arg2_id": "miRNA-corp.d157.s10.e1", "normalized": [] }, { "id": "7487", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d157.s10.e0", "arg2_id": "miRNA-corp.d157.s10.e2", "normalized": [] }, { "id": "7488", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d157.s12.e0", "arg2_id": "miRNA-corp.d157.s12.e2", "normalized": [] }, { "id": "7489", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d157.s12.e0", "arg2_id": "miRNA-corp.d157.s12.e3", "normalized": [] }, { "id": "7490", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d157.s12.e0", "arg2_id": "miRNA-corp.d157.s12.e4", "normalized": [] }, { "id": "7491", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d157.s12.e0", "arg2_id": "miRNA-corp.d157.s12.e5", "normalized": [] }, { "id": "7492", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d157.s12.e1", "arg2_id": "miRNA-corp.d157.s12.e2", "normalized": [] }, { "id": "7493", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d157.s12.e1", "arg2_id": "miRNA-corp.d157.s12.e3", "normalized": [] }, { "id": "7494", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d157.s12.e1", "arg2_id": "miRNA-corp.d157.s12.e4", "normalized": [] }, { "id": "7495", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d157.s12.e1", "arg2_id": "miRNA-corp.d157.s12.e5", "normalized": [] }, { "id": "7496", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d157.s13.e0", "arg2_id": "miRNA-corp.d157.s13.e1", "normalized": [] }, { "id": "7497", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d157.s13.e0", "arg2_id": "miRNA-corp.d157.s13.e2", "normalized": [] }, { "id": "7498", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d157.s13.e0", "arg2_id": "miRNA-corp.d157.s13.e3", "normalized": [] }, { "id": "7499", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d157.s14.e0", "arg2_id": "miRNA-corp.d157.s14.e1", "normalized": [] }, { "id": "7500", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d157.s15.e0", "arg2_id": "miRNA-corp.d157.s15.e1", "normalized": [] } ]

[ { "id": "7502", "type": "title", "text": [ "Many tools have been developed to help describe the repertoire of miRNAs present at the tissue level in a given sample. " ], "offsets": [ [ 0, 120 ] ] }, { "id": "7503", "type": "abstract", "text": [ "To understand how miRNAs contribute to normal biologic functions and disease states, it is critical to understand the miRNAs that are expressed in particular cell types under a range of conditions. " ], "offsets": [ [ 121, 319 ] ] }, { "id": "7504", "type": "abstract", "text": [ "However, tissue level miRNA profiling is inadequate to pinpoint the cellular and sub-cellular distribution of individual miRNAs. " ], "offsets": [ [ 320, 449 ] ] }, { "id": "7505", "type": "abstract", "text": [ "In situ hybridization is a necessary experimental complement to microRNA (miRNA) expression profiling in the human brain. " ], "offsets": [ [ 450, 573 ] ] }, { "id": "7506", "type": "abstract", "text": [ "MicroRNAs (miRNAs) play fundamental roles in human brain neurochemistry. " ], "offsets": [ [ 574, 647 ] ] }, { "id": "7507", "type": "abstract", "text": [ "Thus, in situ hybridization is an important experimental complement to tissue level miRNA expression profiling. " ], "offsets": [ [ 648, 760 ] ] }, { "id": "7508", "type": "abstract", "text": [ "We have found that in situ hybridization shows important cerebral cortical lamina-specific patterns of miRNA expression that would be lost on most tissue level expression studies, and these lamina-specific patterns can be directly relevant to human brain disease. " ], "offsets": [ [ 761, 1025 ] ] }, { "id": "7509", "type": "abstract", "text": [ "Technical and theoretical aspects of this important technique are described, especially those pertinent to studying the human brain. " ], "offsets": [ [ 1026, 1161 ] ] } ]

[ { "id": "7510", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 66, 72 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d158.s0.e0" } ] }, { "id": "7511", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 139, 145 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d158.s1.e0" } ] }, { "id": "7512", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 239, 245 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d158.s1.e1" } ] }, { "id": "7513", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 342, 347 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d158.s3.e0" } ] }, { "id": "7514", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 441, 447 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d158.s3.e1" } ] }, { "id": "7515", "type": "Non-Specific_miRNAs", "text": [ "microRNA" ], "offsets": [ [ 514, 522 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d158.s4.e0" } ] }, { "id": "7516", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 524, 529 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d158.s4.e1" } ] }, { "id": "7517", "type": "Species", "text": [ "human" ], "offsets": [ [ 559, 564 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d158.s4.e2" } ] }, { "id": "7518", "type": "Non-Specific_miRNAs", "text": [ "MicroRNAs" ], "offsets": [ [ 574, 583 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d158.s6.e0" } ] }, { "id": "7519", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 585, 591 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d158.s6.e1" } ] }, { "id": "7520", "type": "Species", "text": [ "human" ], "offsets": [ [ 619, 624 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d158.s6.e2" } ] }, { "id": "7521", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 732, 737 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d158.s7.e0" } ] }, { "id": "7522", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 864, 869 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d158.s8.e0" } ] }, { "id": "7523", "type": "Relation_Trigger", "text": [ "expression that would be lost" ], "offsets": [ [ 870, 899 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d158.s8.e1" } ] }, { "id": "7524", "type": "Relation_Trigger", "text": [ "lost on most tissue level expression" ], "offsets": [ [ 895, 931 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d158.s8.e2" } ] }, { "id": "7525", "type": "Diseases", "text": [ "human brain disease" ], "offsets": [ [ 1004, 1023 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d158.s8.e3" } ] }, { "id": "7526", "type": "Species", "text": [ "human" ], "offsets": [ [ 1004, 1009 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d158.s8.e4" } ] }, { "id": "7527", "type": "Species", "text": [ "human" ], "offsets": [ [ 1146, 1151 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d158.s9.e0" } ] } ]

[]

[]

[ { "id": "7528", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d158.s8.e0", "arg2_id": "miRNA-corp.d158.s8.e3", "normalized": [] } ]

[ { "id": "7530", "type": "title", "text": [ "However, we report the experience of a patient who inadvertently received live polio vaccine whilst receiving anti-TNF therapy. " ], "offsets": [ [ 0, 128 ] ] }, { "id": "7531", "type": "abstract", "text": [ "International guidelines state that live vaccines are contraindicated in patients on anti-TNF therapy. " ], "offsets": [ [ 129, 232 ] ] }, { "id": "7532", "type": "abstract", "text": [ "Live polio vaccine exposure while receiving anti-TNF therapy for reactive arthritis. " ], "offsets": [ [ 233, 319 ] ] }, { "id": "7533", "type": "abstract", "text": [ "Patients should be counseled regarding the risks of live vaccines prior to treatment with anti-TNF therapy. " ], "offsets": [ [ 320, 430 ] ] }, { "id": "7534", "type": "abstract", "text": [ "However, if we consider adult patients with rheumatic diseases to have altered immunocompetence, it is recommended that they receive the usual inactivated vaccines according to standard schedules, and live vaccines should be avoided in those who are treated with more potent forms of immune suppression. " ], "offsets": [ [ 431, 735 ] ] }, { "id": "7535", "type": "abstract", "text": [ "No clear guidelines are available for all vaccines in patients with specific rheumatic diseases. " ], "offsets": [ [ 736, 833 ] ] }, { "id": "7536", "type": "abstract", "text": [ "Patient did not suffer from any infectious sequel as a result. " ], "offsets": [ [ 834, 897 ] ] } ]

[ { "id": "7537", "type": "Diseases", "text": [ "polio" ], "offsets": [ [ 79, 84 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d159.s0.e0" } ] }, { "id": "7538", "type": "Species", "text": [ "patient" ], "offsets": [ [ 39, 46 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d159.s0.e1" } ] }, { "id": "7539", "type": "Species", "text": [ "patients" ], "offsets": [ [ 202, 210 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d159.s1.e0" } ] }, { "id": "7540", "type": "Diseases", "text": [ "polio" ], "offsets": [ [ 238, 243 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d159.s2.e0" } ] }, { "id": "7541", "type": "Diseases", "text": [ "arthritis" ], "offsets": [ [ 307, 316 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d159.s2.e1" } ] }, { "id": "7542", "type": "Species", "text": [ "Patients" ], "offsets": [ [ 320, 328 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d159.s3.e0" } ] }, { "id": "7543", "type": "Relation_Trigger", "text": [ "suppression" ], "offsets": [ [ 722, 733 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d159.s4.e0" } ] }, { "id": "7544", "type": "Diseases", "text": [ "rheumatic diseases" ], "offsets": [ [ 475, 493 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d159.s4.e1" } ] }, { "id": "7545", "type": "Species", "text": [ "patients" ], "offsets": [ [ 461, 469 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d159.s4.e2" } ] }, { "id": "7546", "type": "Diseases", "text": [ "rheumatic diseases" ], "offsets": [ [ 813, 831 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d159.s5.e0" } ] }, { "id": "7547", "type": "Species", "text": [ "patients" ], "offsets": [ [ 790, 798 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d159.s5.e1" } ] }, { "id": "7548", "type": "Species", "text": [ "Patient" ], "offsets": [ [ 834, 841 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d159.s6.e0" } ] } ]

[]

[]

[]

[ { "id": "7550", "type": "title", "text": [ "Thus we have identified the miRNA expression signature for malignant astrocytoma, in particular glioblastoma, and showed the miRNA involvement and their importance in astrocytoma development. " ], "offsets": [ [ 0, 194 ] ] }, { "id": "7551", "type": "abstract", "text": [ "Inhibition of two glioblastoma-upregulated miRNAs (miR-21 and miR-23a) and exogenous overexpression of two glioblastoma-downregulated miRNAs (miR-218 and miR-219-5p) resulted in reduced soft agar colony formation but showed varying effects on cell proliferation and chemosensitivity. " ], "offsets": [ [ 195, 479 ] ] }, { "id": "7552", "type": "abstract", "text": [ "Among them, glioblastoma is the most common primary brain tumor with dismal responses to all therapeutic modalities. " ], "offsets": [ [ 480, 597 ] ] }, { "id": "7553", "type": "abstract", "text": [ "Malignant astrocytoma includes anaplastic astrocytoma (grade III) and glioblastoma (grade IV). " ], "offsets": [ [ 598, 693 ] ] }, { "id": "7554", "type": "abstract", "text": [ "Genome-wide expression profiling identifies deregulated miRNAs in malignant astrocytoma. " ], "offsets": [ [ 694, 784 ] ] }, { "id": "7555", "type": "abstract", "text": [ "The differential expression pattern of nine miRNAs was further validated by real-time RT-PCR on an independent set of malignant astrocytomas (n=72) and normal samples (n=7). " ], "offsets": [ [ 785, 959 ] ] }, { "id": "7556", "type": "abstract", "text": [ "More importantly, we identified a most discriminatory 23-miRNA expression signature, by using PAM, which precisely distinguished glioblastoma from anaplastic astrocytoma with an accuracy of 95%. " ], "offsets": [ [ 960, 1155 ] ] }, { "id": "7557", "type": "abstract", "text": [ "We identified several differentially regulated miRNAs between these groups, which could differentiate glioma grades and normal brain as recognized by PCA. " ], "offsets": [ [ 1156, 1311 ] ] }, { "id": "7558", "type": "abstract", "text": [ "We performed a large-scale, genome-wide microRNA (miRNA) (n=756) expression profiling of 26 glioblastoma, 13 anaplastic astrocytoma and 7 normal brain samples with an aim to find deregulated miRNA in malignant astrocytoma. " ], "offsets": [ [ 1312, 1535 ] ] } ]

[ { "id": "7559", "type": "Diseases", "text": [ "astrocytoma" ], "offsets": [ [ 69, 80 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d160.s0.e0" } ] }, { "id": "7560", "type": "Diseases", "text": [ "glioblastoma" ], "offsets": [ [ 96, 108 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d160.s0.e1" } ] }, { "id": "7561", "type": "Diseases", "text": [ "astrocytoma" ], "offsets": [ [ 167, 178 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d160.s0.e2" } ] }, { "id": "7562", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 28, 33 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d160.s0.e3" } ] }, { "id": "7563", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 125, 130 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d160.s0.e4" } ] }, { "id": "7564", "type": "Specific_miRNAs", "text": [ "miR-21" ], "offsets": [ [ 246, 252 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d160.s1.e0" } ] }, { "id": "7565", "type": "Specific_miRNAs", "text": [ "miR-23a" ], "offsets": [ [ 257, 264 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d160.s1.e1" } ] }, { "id": "7566", "type": "Specific_miRNAs", "text": [ "miR-219-5p" ], "offsets": [ [ 349, 359 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d160.s1.e2" } ] }, { "id": "7567", "type": "Specific_miRNAs", "text": [ "miR-218" ], "offsets": [ [ 337, 344 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d160.s1.e3" } ] }, { "id": "7568", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 238, 244 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d160.s1.e4" } ] }, { "id": "7569", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 329, 335 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d160.s1.e5" } ] }, { "id": "7570", "type": "Diseases", "text": [ "glioblastoma" ], "offsets": [ [ 213, 225 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d160.s1.e6" } ] }, { "id": "7571", "type": "Diseases", "text": [ "glioblastoma" ], "offsets": [ [ 302, 314 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d160.s1.e7" } ] }, { "id": "7572", "type": "Relation_Trigger", "text": [ "overexpression" ], "offsets": [ [ 280, 294 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d160.s1.e8" } ] }, { "id": "7573", "type": "Relation_Trigger", "text": [ "Inhibition" ], "offsets": [ [ 195, 205 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d160.s1.e9" } ] }, { "id": "7574", "type": "Diseases", "text": [ "glioblastoma" ], "offsets": [ [ 492, 504 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d160.s2.e0" } ] }, { "id": "7575", "type": "Diseases", "text": [ "brain tumor" ], "offsets": [ [ 532, 543 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d160.s2.e1" } ] }, { "id": "7576", "type": "Diseases", "text": [ "anaplastic astrocytoma" ], "offsets": [ [ 629, 651 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d160.s3.e0" } ] }, { "id": "7577", "type": "Diseases", "text": [ "glioblastoma" ], "offsets": [ [ 668, 680 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d160.s3.e1" } ] }, { "id": "7578", "type": "Diseases", "text": [ "astrocytoma" ], "offsets": [ [ 608, 619 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d160.s3.e2" } ] }, { "id": "7579", "type": "Diseases", "text": [ "astrocytoma" ], "offsets": [ [ 770, 781 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d160.s4.e0" } ] }, { "id": "7580", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 750, 756 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d160.s4.e1" } ] }, { "id": "7581", "type": "Relation_Trigger", "text": [ "deregulated" ], "offsets": [ [ 738, 749 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d160.s4.e2" } ] }, { "id": "7582", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 829, 835 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d160.s5.e0" } ] }, { "id": "7583", "type": "Diseases", "text": [ "astrocytomas" ], "offsets": [ [ 913, 925 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d160.s5.e1" } ] }, { "id": "7584", "type": "Relation_Trigger", "text": [ "differential expression" ], "offsets": [ [ 789, 812 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d160.s5.e2" } ] }, { "id": "7585", "type": "Diseases", "text": [ "glioblastoma" ], "offsets": [ [ 1089, 1101 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d160.s6.e0" } ] }, { "id": "7586", "type": "Diseases", "text": [ "astrocytoma" ], "offsets": [ [ 1118, 1129 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d160.s6.e1" } ] }, { "id": "7587", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1017, 1022 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d160.s6.e2" } ] }, { "id": "7588", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1203, 1209 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d160.s7.e0" } ] }, { "id": "7589", "type": "Relation_Trigger", "text": [ "differentially regulated" ], "offsets": [ [ 1178, 1202 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d160.s7.e1" } ] }, { "id": "7590", "type": "Diseases", "text": [ "glioma" ], "offsets": [ [ 1258, 1264 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d160.s7.e2" } ] }, { "id": "7591", "type": "Diseases", "text": [ "glioblastoma" ], "offsets": [ [ 1404, 1416 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d160.s8.e0" } ] }, { "id": "7592", "type": "Diseases", "text": [ "anaplastic astrocytoma" ], "offsets": [ [ 1421, 1443 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d160.s8.e1" } ] }, { "id": "7593", "type": "Diseases", "text": [ "astrocytoma" ], "offsets": [ [ 1522, 1533 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d160.s8.e2" } ] }, { "id": "7594", "type": "Non-Specific_miRNAs", "text": [ "microRNA" ], "offsets": [ [ 1352, 1360 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d160.s8.e3" } ] }, { "id": "7595", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1362, 1367 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d160.s8.e4" } ] }, { "id": "7596", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1503, 1508 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d160.s8.e5" } ] }, { "id": "7597", "type": "Relation_Trigger", "text": [ "deregulated" ], "offsets": [ [ 1491, 1502 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d160.s8.e6" } ] } ]

[]

[]

[ { "id": "7598", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d160.s0.e3", "arg2_id": "miRNA-corp.d160.s0.e0", "normalized": [] }, { "id": "7599", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d160.s0.e3", "arg2_id": "miRNA-corp.d160.s0.e1", "normalized": [] }, { "id": "7600", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d160.s0.e3", "arg2_id": "miRNA-corp.d160.s0.e2", "normalized": [] }, { "id": "7601", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d160.s0.e4", "arg2_id": "miRNA-corp.d160.s0.e0", "normalized": [] }, { "id": "7602", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d160.s0.e4", "arg2_id": "miRNA-corp.d160.s0.e1", "normalized": [] }, { "id": "7603", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d160.s0.e4", "arg2_id": "miRNA-corp.d160.s0.e2", "normalized": [] }, { "id": "7604", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d160.s1.e0", "arg2_id": "miRNA-corp.d160.s1.e6", "normalized": [] }, { "id": "7605", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d160.s1.e0", "arg2_id": "miRNA-corp.d160.s1.e7", "normalized": [] }, { "id": "7606", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d160.s1.e1", "arg2_id": "miRNA-corp.d160.s1.e6", "normalized": [] }, { "id": "7607", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d160.s1.e1", "arg2_id": "miRNA-corp.d160.s1.e7", "normalized": [] }, { "id": "7608", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d160.s1.e2", "arg2_id": "miRNA-corp.d160.s1.e6", "normalized": [] }, { "id": "7609", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d160.s1.e2", "arg2_id": "miRNA-corp.d160.s1.e7", "normalized": [] }, { "id": "7610", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d160.s1.e3", "arg2_id": "miRNA-corp.d160.s1.e6", "normalized": [] }, { "id": "7611", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d160.s1.e3", "arg2_id": "miRNA-corp.d160.s1.e7", "normalized": [] }, { "id": "7612", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d160.s1.e4", "arg2_id": "miRNA-corp.d160.s1.e6", "normalized": [] }, { "id": "7613", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d160.s1.e4", "arg2_id": "miRNA-corp.d160.s1.e7", "normalized": [] }, { "id": "7614", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d160.s1.e5", "arg2_id": "miRNA-corp.d160.s1.e6", "normalized": [] }, { "id": "7615", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d160.s1.e5", "arg2_id": "miRNA-corp.d160.s1.e7", "normalized": [] }, { "id": "7616", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d160.s4.e1", "arg2_id": "miRNA-corp.d160.s4.e0", "normalized": [] }, { "id": "7617", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d160.s5.e0", "arg2_id": "miRNA-corp.d160.s5.e1", "normalized": [] }, { "id": "7618", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d160.s6.e2", "arg2_id": "miRNA-corp.d160.s6.e0", "normalized": [] }, { "id": "7619", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d160.s6.e2", "arg2_id": "miRNA-corp.d160.s6.e1", "normalized": [] }, { "id": "7620", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d160.s7.e0", "arg2_id": "miRNA-corp.d160.s7.e2", "normalized": [] }, { "id": "7621", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d160.s8.e3", "arg2_id": "miRNA-corp.d160.s8.e0", "normalized": [] }, { "id": "7622", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d160.s8.e3", "arg2_id": "miRNA-corp.d160.s8.e1", "normalized": [] }, { "id": "7623", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d160.s8.e3", "arg2_id": "miRNA-corp.d160.s8.e2", "normalized": [] }, { "id": "7624", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d160.s8.e4", "arg2_id": "miRNA-corp.d160.s8.e0", "normalized": [] }, { "id": "7625", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d160.s8.e4", "arg2_id": "miRNA-corp.d160.s8.e1", "normalized": [] }, { "id": "7626", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d160.s8.e4", "arg2_id": "miRNA-corp.d160.s8.e2", "normalized": [] }, { "id": "7627", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d160.s8.e5", "arg2_id": "miRNA-corp.d160.s8.e0", "normalized": [] }, { "id": "7628", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d160.s8.e5", "arg2_id": "miRNA-corp.d160.s8.e1", "normalized": [] }, { "id": "7629", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d160.s8.e5", "arg2_id": "miRNA-corp.d160.s8.e2", "normalized": [] } ]

[ { "id": "7631", "type": "title", "text": [ "Our findings suggest a functional collaboration between the miR-17 approximately 92 cluster and the SHH signaling pathway in the development of MBs in mouse and man. " ], "offsets": [ [ 0, 168 ] ] }, { "id": "7632", "type": "abstract", "text": [ "Analysis of human MBs demonstrated that 3 miR-17 approximately 92 cluster miRNAs (miR-92, miR-19a, and miR-20) were also overexpressed in human MBs with a constitutively activated Sonic Hedgehog (SHH) signaling pathway, but not in other forms of the disease. " ], "offsets": [ [ 169, 428 ] ] }, { "id": "7633", "type": "abstract", "text": [ "To test whether the miR-17 approximately 92 cluster could promote MB formation, we enforced expression of these miRNAs in GNPs isolated from cerebella of postnatal (P) day P6 Ink4c-/-; Ptch1+/- mice. " ], "offsets": [ [ 429, 629 ] ] }, { "id": "7634", "type": "abstract", "text": [ "These, but not similarly engineered cells from Ink4c-/-; p53-/- mice, formed MBs in orthotopic transplants with complete penetrance. " ], "offsets": [ [ 630, 763 ] ] }, { "id": "7635", "type": "abstract", "text": [ "Interestingly, orthotopic mouse tumors ectopically expressing miR-17 approximately 92 lost expression of the wild-type Ptch1 allele. " ], "offsets": [ [ 764, 897 ] ] }, { "id": "7636", "type": "abstract", "text": [ "Because microRNAs regulate numerous aspects of cellular physiology and development, we reasoned that alterations in miRNA expression might contribute to MB. We tested this hypothesis using 2 spontaneous mouse MB models with specific initiating mutations, Ink4c-/-; Ptch1+/- and Ink4c-/-; p53-/-. " ], "offsets": [ [ 898, 1194 ] ] }, { "id": "7637", "type": "abstract", "text": [ "We found that 26 miRNAs showed increased expression and 24 miRNAs showed decreased expression in proliferating mouse GNPs and MBs relative to mature mouse cerebellum, regardless of genotype. " ], "offsets": [ [ 1195, 1386 ] ] }, { "id": "7638", "type": "abstract", "text": [ "Among the 26 overexpressed miRNAs, 9 were encoded by the miR-17 approximately 92 cluster family, a group of microRNAs implicated as oncogenes in several tumor types. " ], "offsets": [ [ 1387, 1553 ] ] }, { "id": "7639", "type": "abstract", "text": [ "The miR-17~92 cluster collaborates with the Sonic Hedgehog pathway in medulloblastoma. " ], "offsets": [ [ 1554, 1642 ] ] }, { "id": "7640", "type": "abstract", "text": [ "Medulloblastomas (MBs) are the most common brain tumors in children. " ], "offsets": [ [ 1643, 1712 ] ] } ]

[ { "id": "7641", "type": "Specific_miRNAs", "text": [ "miR-17" ], "offsets": [ [ 60, 66 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s0.e0" } ] }, { "id": "7642", "type": "Diseases", "text": [ "MBs" ], "offsets": [ [ 144, 147 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s0.e1" } ] }, { "id": "7643", "type": "Species", "text": [ "mouse" ], "offsets": [ [ 151, 156 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s0.e2" } ] }, { "id": "7644", "type": "Species", "text": [ "man" ], "offsets": [ [ 161, 164 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s0.e3" } ] }, { "id": "7645", "type": "Genes/Proteins", "text": [ "SHH" ], "offsets": [ [ 100, 103 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s0.e4" } ] }, { "id": "7646", "type": "Specific_miRNAs", "text": [ "miR-17" ], "offsets": [ [ 211, 217 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s1.e0" } ] }, { "id": "7647", "type": "Specific_miRNAs", "text": [ "miR-92" ], "offsets": [ [ 251, 257 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s1.e1" } ] }, { "id": "7648", "type": "Specific_miRNAs", "text": [ "miR-19a" ], "offsets": [ [ 259, 266 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s1.e2" } ] }, { "id": "7649", "type": "Specific_miRNAs", "text": [ "miR-20" ], "offsets": [ [ 272, 278 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s1.e3" } ] }, { "id": "7650", "type": "Diseases", "text": [ "MBs" ], "offsets": [ [ 313, 316 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s1.e4" } ] }, { "id": "7651", "type": "Relation_Trigger", "text": [ "overexpressed" ], "offsets": [ [ 290, 303 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s1.e5" } ] }, { "id": "7652", "type": "Relation_Trigger", "text": [ "activated" ], "offsets": [ [ 339, 348 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s1.e6" } ] }, { "id": "7653", "type": "Diseases", "text": [ "human MBs" ], "offsets": [ [ 181, 190 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s1.e7" } ] }, { "id": "7654", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 243, 249 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s1.e8" } ] }, { "id": "7655", "type": "Genes/Proteins", "text": [ "Sonic Hedgehog" ], "offsets": [ [ 349, 363 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s1.e9" } ] }, { "id": "7656", "type": "Genes/Proteins", "text": [ "SHH" ], "offsets": [ [ 365, 368 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s1.e10" } ] }, { "id": "7657", "type": "Species", "text": [ "human" ], "offsets": [ [ 181, 186 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s1.e11" } ] }, { "id": "7658", "type": "Species", "text": [ "human" ], "offsets": [ [ 307, 312 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s1.e12" } ] }, { "id": "7659", "type": "Specific_miRNAs", "text": [ "miR-17" ], "offsets": [ [ 449, 455 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s2.e0" } ] }, { "id": "7660", "type": "Diseases", "text": [ "MB" ], "offsets": [ [ 495, 497 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s2.e1" } ] }, { "id": "7661", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 541, 547 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s2.e2" } ] }, { "id": "7662", "type": "Species", "text": [ "mice" ], "offsets": [ [ 623, 627 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s2.e3" } ] }, { "id": "7663", "type": "Genes/Proteins", "text": [ "Ink4c" ], "offsets": [ [ 604, 609 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s2.e4" } ] }, { "id": "7664", "type": "Diseases", "text": [ "MBs" ], "offsets": [ [ 707, 710 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s3.e0" } ] }, { "id": "7665", "type": "Genes/Proteins", "text": [ "p53" ], "offsets": [ [ 687, 690 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s3.e1" } ] }, { "id": "7666", "type": "Genes/Proteins", "text": [ "Ink4c" ], "offsets": [ [ 677, 682 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s3.e2" } ] }, { "id": "7667", "type": "Species", "text": [ "mice" ], "offsets": [ [ 694, 698 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s3.e3" } ] }, { "id": "7668", "type": "Specific_miRNAs", "text": [ "miR-17" ], "offsets": [ [ 826, 832 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s4.e0" } ] }, { "id": "7669", "type": "Genes/Proteins", "text": [ "Ptch1" ], "offsets": [ [ 883, 888 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s4.e1" } ] }, { "id": "7670", "type": "Relation_Trigger", "text": [ "ectopically expressing" ], "offsets": [ [ 803, 825 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s4.e2" } ] }, { "id": "7671", "type": "Relation_Trigger", "text": [ "lost expression" ], "offsets": [ [ 850, 865 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s4.e3" } ] }, { "id": "7672", "type": "Species", "text": [ "mouse" ], "offsets": [ [ 790, 795 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s4.e4" } ] }, { "id": "7673", "type": "Diseases", "text": [ "tumors" ], "offsets": [ [ 796, 802 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s4.e5" } ] }, { "id": "7674", "type": "Diseases", "text": [ "MB" ], "offsets": [ [ 1051, 1053 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s6.e0" } ] }, { "id": "7675", "type": "Diseases", "text": [ "MB" ], "offsets": [ [ 1107, 1109 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s6.e1" } ] }, { "id": "7676", "type": "Non-Specific_miRNAs", "text": [ "microRNAs" ], "offsets": [ [ 906, 915 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s6.e2" } ] }, { "id": "7677", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1014, 1019 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s6.e3" } ] }, { "id": "7678", "type": "Genes/Proteins", "text": [ "Ink4c" ], "offsets": [ [ 1153, 1158 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s6.e4" } ] }, { "id": "7679", "type": "Genes/Proteins", "text": [ "p53" ], "offsets": [ [ 1186, 1189 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s6.e5" } ] }, { "id": "7680", "type": "Genes/Proteins", "text": [ "Ink4c" ], "offsets": [ [ 1176, 1181 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s6.e6" } ] }, { "id": "7681", "type": "Relation_Trigger", "text": [ "regulate" ], "offsets": [ [ 916, 924 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s6.e7" } ] }, { "id": "7682", "type": "Relation_Trigger", "text": [ "alterations in miRNA expression" ], "offsets": [ [ 999, 1030 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s6.e8" } ] }, { "id": "7683", "type": "Species", "text": [ "mouse" ], "offsets": [ [ 1101, 1106 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s6.e9" } ] }, { "id": "7684", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1212, 1218 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s7.e0" } ] }, { "id": "7685", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1254, 1260 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s7.e1" } ] }, { "id": "7686", "type": "Diseases", "text": [ "MBs" ], "offsets": [ [ 1321, 1324 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s7.e2" } ] }, { "id": "7687", "type": "Relation_Trigger", "text": [ "increased expression" ], "offsets": [ [ 1226, 1246 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s7.e3" } ] }, { "id": "7688", "type": "Relation_Trigger", "text": [ "decreased expression" ], "offsets": [ [ 1268, 1288 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s7.e4" } ] }, { "id": "7689", "type": "Species", "text": [ "mouse" ], "offsets": [ [ 1306, 1311 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s7.e5" } ] }, { "id": "7690", "type": "Species", "text": [ "mouse" ], "offsets": [ [ 1344, 1349 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s7.e6" } ] }, { "id": "7691", "type": "Specific_miRNAs", "text": [ "miR-17" ], "offsets": [ [ 1444, 1450 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s8.e0" } ] }, { "id": "7692", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1414, 1420 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s8.e1" } ] }, { "id": "7693", "type": "Non-Specific_miRNAs", "text": [ "microRNAs" ], "offsets": [ [ 1495, 1504 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s8.e2" } ] }, { "id": "7694", "type": "Relation_Trigger", "text": [ "overexpressed" ], "offsets": [ [ 1400, 1413 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s8.e3" } ] }, { "id": "7695", "type": "Diseases", "text": [ "tumor" ], "offsets": [ [ 1540, 1545 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s8.e4" } ] }, { "id": "7696", "type": "Specific_miRNAs", "text": [ "miR-17~92" ], "offsets": [ [ 1558, 1567 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s9.e0" } ] }, { "id": "7697", "type": "Diseases", "text": [ "medulloblastoma" ], "offsets": [ [ 1624, 1639 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s9.e1" } ] }, { "id": "7698", "type": "Genes/Proteins", "text": [ "Sonic Hedgehog" ], "offsets": [ [ 1598, 1612 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s9.e2" } ] }, { "id": "7699", "type": "Diseases", "text": [ "brain tumors" ], "offsets": [ [ 1686, 1698 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s10.e0" } ] }, { "id": "7700", "type": "Diseases", "text": [ "Medulloblastomas" ], "offsets": [ [ 1643, 1659 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s10.e1" } ] }, { "id": "7701", "type": "Diseases", "text": [ "MBs" ], "offsets": [ [ 1661, 1664 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s10.e2" } ] }, { "id": "7702", "type": "Diseases", "text": [ "tumors" ], "offsets": [ [ 1692, 1698 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s10.e3" } ] }, { "id": "7703", "type": "Species", "text": [ "children" ], "offsets": [ [ 1702, 1710 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d161.s10.e4" } ] } ]

[]

[]

[ { "id": "7704", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d161.s0.e0", "arg2_id": "miRNA-corp.d161.s0.e1", "normalized": [] }, { "id": "7705", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d161.s0.e0", "arg2_id": "miRNA-corp.d161.s0.e4", "normalized": [] }, { "id": "7706", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d161.s1.e0", "arg2_id": "miRNA-corp.d161.s1.e4", "normalized": [] }, { "id": "7707", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d161.s1.e0", "arg2_id": "miRNA-corp.d161.s1.e7", "normalized": [] }, { "id": "7708", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d161.s1.e0", "arg2_id": "miRNA-corp.d161.s1.e9", "normalized": [] }, { "id": "7709", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d161.s1.e0", "arg2_id": "miRNA-corp.d161.s1.e10", "normalized": [] }, { "id": "7710", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d161.s1.e1", "arg2_id": "miRNA-corp.d161.s1.e4", "normalized": [] }, { "id": "7711", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d161.s1.e1", "arg2_id": "miRNA-corp.d161.s1.e7", "normalized": [] }, { "id": "7712", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d161.s1.e1", "arg2_id": "miRNA-corp.d161.s1.e9", "normalized": [] }, { "id": "7713", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d161.s1.e1", "arg2_id": "miRNA-corp.d161.s1.e10", "normalized": [] }, { "id": "7714", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d161.s1.e2", "arg2_id": "miRNA-corp.d161.s1.e4", "normalized": [] }, { "id": "7715", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d161.s1.e2", "arg2_id": "miRNA-corp.d161.s1.e7", "normalized": [] }, { "id": "7716", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d161.s1.e2", "arg2_id": "miRNA-corp.d161.s1.e9", "normalized": [] }, { "id": "7717", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d161.s1.e2", "arg2_id": "miRNA-corp.d161.s1.e10", "normalized": [] }, { "id": "7718", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d161.s1.e8", "arg2_id": "miRNA-corp.d161.s1.e4", "normalized": [] }, { "id": "7719", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d161.s1.e8", "arg2_id": "miRNA-corp.d161.s1.e7", "normalized": [] }, { "id": "7720", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d161.s1.e8", "arg2_id": "miRNA-corp.d161.s1.e9", "normalized": [] }, { "id": "7721", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d161.s1.e8", "arg2_id": "miRNA-corp.d161.s1.e10", "normalized": [] }, { "id": "7722", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d161.s1.e3", "arg2_id": "miRNA-corp.d161.s1.e4", "normalized": [] }, { "id": "7723", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d161.s1.e3", "arg2_id": "miRNA-corp.d161.s1.e7", "normalized": [] }, { "id": "7724", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d161.s1.e3", "arg2_id": "miRNA-corp.d161.s1.e9", "normalized": [] }, { "id": "7725", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d161.s1.e3", "arg2_id": "miRNA-corp.d161.s1.e10", "normalized": [] }, { "id": "7726", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d161.s2.e2", "arg2_id": "miRNA-corp.d161.s2.e1", "normalized": [] }, { "id": "7727", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d161.s2.e2", "arg2_id": "miRNA-corp.d161.s2.e4", "normalized": [] }, { "id": "7728", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d161.s2.e0", "arg2_id": "miRNA-corp.d161.s2.e1", "normalized": [] }, { "id": "7729", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d161.s2.e0", "arg2_id": "miRNA-corp.d161.s2.e4", "normalized": [] }, { "id": "7730", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d161.s4.e0", "arg2_id": "miRNA-corp.d161.s4.e1", "normalized": [] }, { "id": "7731", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d161.s4.e0", "arg2_id": "miRNA-corp.d161.s4.e5", "normalized": [] }, { "id": "7732", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d161.s6.e2", "arg2_id": "miRNA-corp.d161.s6.e0", "normalized": [] }, { "id": "7733", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d161.s6.e2", "arg2_id": "miRNA-corp.d161.s6.e1", "normalized": [] }, { "id": "7734", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d161.s6.e2", "arg2_id": "miRNA-corp.d161.s6.e4", "normalized": [] }, { "id": "7735", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d161.s6.e2", "arg2_id": "miRNA-corp.d161.s6.e5", "normalized": [] }, { "id": "7736", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d161.s6.e2", "arg2_id": "miRNA-corp.d161.s6.e6", "normalized": [] }, { "id": "7737", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d161.s6.e3", "arg2_id": "miRNA-corp.d161.s6.e0", "normalized": [] }, { "id": "7738", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d161.s6.e3", "arg2_id": "miRNA-corp.d161.s6.e1", "normalized": [] }, { "id": "7739", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d161.s6.e3", "arg2_id": "miRNA-corp.d161.s6.e4", "normalized": [] }, { "id": "7740", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d161.s6.e3", "arg2_id": "miRNA-corp.d161.s6.e5", "normalized": [] }, { "id": "7741", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d161.s6.e3", "arg2_id": "miRNA-corp.d161.s6.e6", "normalized": [] }, { "id": "7742", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d161.s7.e0", "arg2_id": "miRNA-corp.d161.s7.e2", "normalized": [] }, { "id": "7743", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d161.s7.e1", "arg2_id": "miRNA-corp.d161.s7.e2", "normalized": [] }, { "id": "7744", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d161.s8.e0", "arg2_id": "miRNA-corp.d161.s8.e4", "normalized": [] }, { "id": "7745", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d161.s8.e1", "arg2_id": "miRNA-corp.d161.s8.e4", "normalized": [] }, { "id": "7746", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d161.s8.e2", "arg2_id": "miRNA-corp.d161.s8.e4", "normalized": [] }, { "id": "7747", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d161.s9.e0", "arg2_id": "miRNA-corp.d161.s9.e1", "normalized": [] }, { "id": "7748", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d161.s9.e0", "arg2_id": "miRNA-corp.d161.s9.e2", "normalized": [] } ]

[ { "id": "7750", "type": "title", "text": [ "Autosomal-recessive cerebellar ataxias comprise a clinically and genetically heterogeneous group of neurodegenerative disorders. " ], "offsets": [ [ 0, 129 ] ] }, { "id": "7751", "type": "abstract", "text": [ "In contrast to their dominant counterparts, unraveling the molecular background of these ataxias has proven to be more complicated and the currently known mutations provide incomplete coverage for genotyping of patients. " ], "offsets": [ [ 130, 351 ] ] }, { "id": "7752", "type": "abstract", "text": [ "By combining SNP array-based linkage analysis and targeted resequencing of relevant sequences in the linkage interval with the use of next-generation sequencing technology, we identified a mutation in a gene and have shown its association with autosomal-recessive cerebellar ataxia. " ], "offsets": [ [ 352, 635 ] ] }, { "id": "7753", "type": "abstract", "text": [ "In a Dutch consanguineous family with three affected siblings a homozygous 12.5 Mb region on chromosome 3 was targeted by array-based sequence capture. " ], "offsets": [ [ 636, 788 ] ] }, { "id": "7754", "type": "abstract", "text": [ "Targeted next-generation sequencing of a 12.5 Mb homozygous region reveals ANO10 mutations in patients with autosomal-recessive cerebellar ataxia. " ], "offsets": [ [ 789, 937 ] ] }, { "id": "7755", "type": "abstract", "text": [ "The analysis of ANO10 by Sanger sequencing revealed three additional mutations: a homozygous mutation (c.1150_1151del [p.Leu384fs]) in a Serbian family and a compound-heterozygous splice-site mutation (c.1476+1G>T) and a frameshift mutation (c.1604del [p.Leu535X]) in a French family. " ], "offsets": [ [ 938, 1223 ] ] }, { "id": "7756", "type": "abstract", "text": [ "This variant was a leucine-to-arginine substitution in the DUF 590 domain of a 16K transmembrane protein, a putative calcium-activated chloride channel encoded by anoctamin 10 (ANO10). " ], "offsets": [ [ 1224, 1409 ] ] }, { "id": "7757", "type": "abstract", "text": [ "Moreover, identifying a putative calcium-dependent chloride channel involved in cerebellar ataxia adds another pathway to the list of pathophysiological mechanisms that may cause cerebellar ataxia. " ], "offsets": [ [ 1410, 1610 ] ] } ]

[ { "id": "7758", "type": "Diseases", "text": [ "Autosomal-recessive cerebellar ataxias" ], "offsets": [ [ 0, 38 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d162.s0.e0" } ] }, { "id": "7759", "type": "Diseases", "text": [ "neurodegenerative disorders" ], "offsets": [ [ 100, 127 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d162.s0.e1" } ] }, { "id": "7760", "type": "Diseases", "text": [ "ataxias" ], "offsets": [ [ 219, 226 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d162.s1.e0" } ] }, { "id": "7761", "type": "Species", "text": [ "patients" ], "offsets": [ [ 341, 349 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d162.s1.e1" } ] }, { "id": "7762", "type": "Relation_Trigger", "text": [ "targeted" ], "offsets": [ [ 402, 410 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d162.s2.e0" } ] }, { "id": "7763", "type": "Relation_Trigger", "text": [ "association" ], "offsets": [ [ 579, 590 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d162.s2.e1" } ] }, { "id": "7764", "type": "Diseases", "text": [ "autosomal-recessive cerebellar ataxia" ], "offsets": [ [ 596, 633 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d162.s2.e2" } ] }, { "id": "7765", "type": "Relation_Trigger", "text": [ "targeted" ], "offsets": [ [ 746, 754 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d162.s3.e0" } ] }, { "id": "7766", "type": "Relation_Trigger", "text": [ "Targeted" ], "offsets": [ [ 789, 797 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d162.s4.e0" } ] }, { "id": "7767", "type": "Diseases", "text": [ "autosomal-recessive cerebellar ataxia" ], "offsets": [ [ 897, 934 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d162.s4.e1" } ] }, { "id": "7768", "type": "Genes/Proteins", "text": [ "ANO10" ], "offsets": [ [ 864, 869 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d162.s4.e2" } ] }, { "id": "7769", "type": "Species", "text": [ "patients" ], "offsets": [ [ 883, 891 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d162.s4.e3" } ] }, { "id": "7770", "type": "Genes/Proteins", "text": [ "ANO10" ], "offsets": [ [ 954, 959 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d162.s5.e0" } ] }, { "id": "7771", "type": "Genes/Proteins", "text": [ "ANO10" ], "offsets": [ [ 1401, 1406 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d162.s8.e0" } ] }, { "id": "7772", "type": "Genes/Proteins", "text": [ "anoctamin 10" ], "offsets": [ [ 1387, 1399 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d162.s8.e1" } ] }, { "id": "7773", "type": "Diseases", "text": [ "cerebellar ataxia" ], "offsets": [ [ 1490, 1507 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d162.s9.e0" } ] }, { "id": "7774", "type": "Diseases", "text": [ "cerebellar ataxia" ], "offsets": [ [ 1589, 1606 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d162.s9.e1" } ] } ]

[]

[]

[]

[ { "id": "7776", "type": "title", "text": [ "Since over-expression of human SNCA (hSNCA) leads to death of dopaminergic (DA) neurons in human, rodent and fly brain, hSNCA gene silencing may reduce levels of toxic forms of SNCA and ameliorate degeneration of DA neurons in PD. " ], "offsets": [ [ 0, 231 ] ] }, { "id": "7777", "type": "abstract", "text": [ "Alpha-synuclein (SNCA), an abundantly expressed presynaptic protein, is implicated in Parkinson's disease (PD). " ], "offsets": [ [ 232, 344 ] ] }, { "id": "7778", "type": "abstract", "text": [ "A microRNA embedded AAV alpha-synuclein gene silencing vector for dopaminergic neurons. " ], "offsets": [ [ 345, 434 ] ] }, { "id": "7779", "type": "abstract", "text": [ "Our in vitro data suggest that this miRNA-embedded silencing vector may be ideal for chronic in vivo SNCA gene silencing in DA neurons. " ], "offsets": [ [ 435, 573 ] ] }, { "id": "7780", "type": "abstract", "text": [ "However, the mir30 embedded vector was significantly less toxic to both PC12 and SH-SY5Y cells. " ], "offsets": [ [ 574, 670 ] ] }, { "id": "7781", "type": "abstract", "text": [ "In DA PC12 cells, neither vector decreased expression of rat SNCA, tyrosine hydroxylase (TH), dopamine transporter (DAT) or the vesicular monoamine transporter (VMAT). " ], "offsets": [ [ 671, 839 ] ] }, { "id": "7782", "type": "abstract", "text": [ "The same hSNCA silencing sequence (shRNA) was used in both vectors, but in one vector, the shRNA was embedded in a microRNA backbone and driven by a pol II promoter, and in the other the shRNA was not embedded in a microRNA and was driven by a pol III promoter. " ], "offsets": [ [ 840, 1102 ] ] }, { "id": "7783", "type": "abstract", "text": [ "To begin to develop a gene therapy for PD based on hSNCA gene silencing, two AAV gene silencing vectors were designed, and tested for efficiency and specificity of silencing, as well as toxicity in vitro. " ], "offsets": [ [ 1103, 1308 ] ] } ]

[ { "id": "7784", "type": "Genes/Proteins", "text": [ "SNCA" ], "offsets": [ [ 31, 35 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d163.s0.e0" } ] }, { "id": "7785", "type": "Genes/Proteins", "text": [ "SNCA" ], "offsets": [ [ 177, 181 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d163.s0.e1" } ] }, { "id": "7786", "type": "Diseases", "text": [ "PD" ], "offsets": [ [ 227, 229 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d163.s0.e2" } ] }, { "id": "7787", "type": "Relation_Trigger", "text": [ "over-expression" ], "offsets": [ [ 6, 21 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d163.s0.e3" } ] }, { "id": "7788", "type": "Relation_Trigger", "text": [ "reduce levels" ], "offsets": [ [ 145, 158 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d163.s0.e4" } ] }, { "id": "7789", "type": "Species", "text": [ "human" ], "offsets": [ [ 25, 30 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d163.s0.e5" } ] }, { "id": "7790", "type": "Species", "text": [ "human" ], "offsets": [ [ 91, 96 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d163.s0.e6" } ] }, { "id": "7791", "type": "Genes/Proteins", "text": [ "Alpha-synuclein" ], "offsets": [ [ 232, 247 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d163.s1.e0" } ] }, { "id": "7792", "type": "Genes/Proteins", "text": [ "SNCA" ], "offsets": [ [ 249, 253 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d163.s1.e1" } ] }, { "id": "7793", "type": "Diseases", "text": [ "Parkinson's disease" ], "offsets": [ [ 318, 337 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d163.s1.e2" } ] }, { "id": "7794", "type": "Diseases", "text": [ "PD" ], "offsets": [ [ 339, 341 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d163.s1.e3" } ] }, { "id": "7795", "type": "Relation_Trigger", "text": [ "abundantly expressed" ], "offsets": [ [ 259, 279 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d163.s1.e4" } ] }, { "id": "7796", "type": "Non-Specific_miRNAs", "text": [ "microRNA" ], "offsets": [ [ 347, 355 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d163.s2.e0" } ] }, { "id": "7797", "type": "Genes/Proteins", "text": [ "alpha-synuclein" ], "offsets": [ [ 369, 384 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d163.s2.e1" } ] }, { "id": "7798", "type": "Genes/Proteins", "text": [ "AAV" ], "offsets": [ [ 365, 368 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d163.s2.e2" } ] }, { "id": "7799", "type": "Genes/Proteins", "text": [ "SNCA" ], "offsets": [ [ 536, 540 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d163.s3.e0" } ] }, { "id": "7800", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 471, 476 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d163.s3.e1" } ] }, { "id": "7801", "type": "Specific_miRNAs", "text": [ "mir30" ], "offsets": [ [ 587, 592 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d163.s4.e0" } ] }, { "id": "7802", "type": "Genes/Proteins", "text": [ "SNCA" ], "offsets": [ [ 732, 736 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d163.s5.e0" } ] }, { "id": "7803", "type": "Genes/Proteins", "text": [ "tyrosine hydroxylase" ], "offsets": [ [ 738, 758 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d163.s5.e1" } ] }, { "id": "7804", "type": "Relation_Trigger", "text": [ "decreased expression" ], "offsets": [ [ 704, 724 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d163.s5.e2" } ] }, { "id": "7805", "type": "Genes/Proteins", "text": [ "vesicular monoamine transporter" ], "offsets": [ [ 799, 830 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d163.s5.e3" } ] }, { "id": "7806", "type": "Genes/Proteins", "text": [ "dopamine transporter" ], "offsets": [ [ 765, 785 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d163.s5.e4" } ] }, { "id": "7807", "type": "Species", "text": [ "rat" ], "offsets": [ [ 728, 731 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d163.s5.e5" } ] }, { "id": "7808", "type": "Non-Specific_miRNAs", "text": [ "microRNA" ], "offsets": [ [ 955, 963 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d163.s7.e0" } ] }, { "id": "7809", "type": "Non-Specific_miRNAs", "text": [ "microRNA" ], "offsets": [ [ 1055, 1063 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d163.s7.e1" } ] }, { "id": "7810", "type": "Diseases", "text": [ "PD" ], "offsets": [ [ 1142, 1144 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d163.s8.e0" } ] }, { "id": "7811", "type": "Genes/Proteins", "text": [ "AAV" ], "offsets": [ [ 1180, 1183 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d163.s8.e1" } ] } ]

[]

[]

[ { "id": "7812", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d163.s2.e0", "arg2_id": "miRNA-corp.d163.s2.e1", "normalized": [] }, { "id": "7813", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d163.s2.e0", "arg2_id": "miRNA-corp.d163.s2.e2", "normalized": [] }, { "id": "7814", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d163.s3.e1", "arg2_id": "miRNA-corp.d163.s3.e0", "normalized": [] } ]

[ { "id": "7816", "type": "title", "text": [ "Taken together, induction of microRNA expression in BMC may contribute to the aberrant systemic decline in mRNA levels in sporadic AD. " ], "offsets": [ [ 0, 137 ] ] }, { "id": "7817", "type": "abstract", "text": [ "MicroRNA expression in Alzheimer blood mononuclear cells. " ], "offsets": [ [ 138, 197 ] ] }, { "id": "7818", "type": "abstract", "text": [ "Various coding genes representing multiple functional categories are downregulated in blood mononuclear cells (BMC) of patients with sporadic Alzheimer disease (AD). " ], "offsets": [ [ 198, 364 ] ] }, { "id": "7819", "type": "abstract", "text": [ "Noncoding microRNAs (miRNA) regulate gene expression by degrading messages or inhibiting translation. " ], "offsets": [ [ 365, 467 ] ] }, { "id": "7820", "type": "abstract", "text": [ "Using BMC as a paradigm for the study of systemic alterations in AD, we investigated whether peripheral miRNA expression is altered in this condition. " ], "offsets": [ [ 468, 619 ] ] }, { "id": "7821", "type": "abstract", "text": [ "MicroRNA levels were assessed using the microRNA microarray (MMChip) containing 462 human miRNA, and the results validated by real time PCR. " ], "offsets": [ [ 620, 761 ] ] }, { "id": "7822", "type": "abstract", "text": [ "Sixteen AD patients and sixteen normal elderly controls (NEC) were matched for ethnicity, age, gender and education. " ], "offsets": [ [ 762, 879 ] ] }, { "id": "7823", "type": "abstract", "text": [ "The expression of several BMC miRNAs was found to increase in AD relative to NEC levels, and may differ between AD subjects bearing one or two APOE4 alleles. " ], "offsets": [ [ 880, 1038 ] ] }, { "id": "7824", "type": "abstract", "text": [ "As compared to NEC, miRNAs significantly upregulated in AD subjects and confirmed by qPCR were miR-34a and 181b. " ], "offsets": [ [ 1039, 1152 ] ] }, { "id": "7825", "type": "abstract", "text": [ "Predicted target genes downregulated in Alzheimer BMC that correlated with the upregulated miRNAs were largely represented in the functional categories of Transcription/Translation and Synaptic Activity. " ], "offsets": [ [ 1153, 1357 ] ] }, { "id": "7826", "type": "abstract", "text": [ "Several miRNAs targeting the same genes were within the functional category of Injury response/Redox homeostasis. " ], "offsets": [ [ 1358, 1472 ] ] } ]

[ { "id": "7827", "type": "Non-Specific_miRNAs", "text": [ "microRNA" ], "offsets": [ [ 29, 37 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d164.s0.e0" } ] }, { "id": "7828", "type": "Diseases", "text": [ "sporadic AD" ], "offsets": [ [ 122, 133 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d164.s0.e1" } ] }, { "id": "7829", "type": "Diseases", "text": [ "Alzheimer" ], "offsets": [ [ 161, 170 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d164.s1.e0" } ] }, { "id": "7830", "type": "Non-Specific_miRNAs", "text": [ "MicroRNA" ], "offsets": [ [ 138, 146 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d164.s1.e1" } ] }, { "id": "7831", "type": "Diseases", "text": [ "Alzheimer disease" ], "offsets": [ [ 340, 357 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d164.s2.e0" } ] }, { "id": "7832", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 359, 361 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d164.s2.e1" } ] }, { "id": "7833", "type": "Relation_Trigger", "text": [ "downregulated" ], "offsets": [ [ 267, 280 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d164.s2.e2" } ] }, { "id": "7834", "type": "Species", "text": [ "patients" ], "offsets": [ [ 317, 325 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d164.s2.e3" } ] }, { "id": "7835", "type": "Non-Specific_miRNAs", "text": [ "microRNAs" ], "offsets": [ [ 375, 384 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d164.s3.e0" } ] }, { "id": "7836", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 386, 391 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d164.s3.e1" } ] }, { "id": "7837", "type": "Relation_Trigger", "text": [ "inhibiting translation" ], "offsets": [ [ 443, 465 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d164.s3.e2" } ] }, { "id": "7838", "type": "Relation_Trigger", "text": [ "regulate gene expression" ], "offsets": [ [ 393, 417 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d164.s3.e3" } ] }, { "id": "7839", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 533, 535 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d164.s4.e0" } ] }, { "id": "7840", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 572, 577 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d164.s4.e1" } ] }, { "id": "7841", "type": "Relation_Trigger", "text": [ "expression is altered" ], "offsets": [ [ 578, 599 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d164.s4.e2" } ] }, { "id": "7842", "type": "Non-Specific_miRNAs", "text": [ "MicroRNA" ], "offsets": [ [ 620, 628 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d164.s5.e0" } ] }, { "id": "7843", "type": "Non-Specific_miRNAs", "text": [ "microRNA" ], "offsets": [ [ 660, 668 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d164.s5.e1" } ] }, { "id": "7844", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 710, 715 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d164.s5.e2" } ] }, { "id": "7845", "type": "Species", "text": [ "human" ], "offsets": [ [ 704, 709 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d164.s5.e3" } ] }, { "id": "7846", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 770, 772 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d164.s6.e0" } ] }, { "id": "7847", "type": "Species", "text": [ "patients" ], "offsets": [ [ 773, 781 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d164.s6.e1" } ] }, { "id": "7848", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 992, 994 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d164.s7.e0" } ] }, { "id": "7849", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 942, 944 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d164.s7.e1" } ] }, { "id": "7850", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 910, 916 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d164.s7.e2" } ] }, { "id": "7851", "type": "Relation_Trigger", "text": [ "expression of several BMC miRNAs was found to increase" ], "offsets": [ [ 884, 938 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d164.s7.e3" } ] }, { "id": "7852", "type": "Specific_miRNAs", "text": [ "miR-34a and 181b" ], "offsets": [ [ 1134, 1150 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d164.s8.e0" } ] }, { "id": "7853", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 1095, 1097 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d164.s8.e1" } ] }, { "id": "7854", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1059, 1065 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d164.s8.e2" } ] }, { "id": "7855", "type": "Relation_Trigger", "text": [ "upregulated" ], "offsets": [ [ 1080, 1091 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d164.s8.e3" } ] }, { "id": "7856", "type": "Diseases", "text": [ "Alzheimer" ], "offsets": [ [ 1193, 1202 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d164.s9.e0" } ] }, { "id": "7857", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1244, 1250 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d164.s9.e1" } ] }, { "id": "7858", "type": "Relation_Trigger", "text": [ "downregulated" ], "offsets": [ [ 1176, 1189 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d164.s9.e2" } ] }, { "id": "7859", "type": "Relation_Trigger", "text": [ "correlated" ], "offsets": [ [ 1212, 1222 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d164.s9.e3" } ] }, { "id": "7860", "type": "Relation_Trigger", "text": [ "upregulated" ], "offsets": [ [ 1232, 1243 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d164.s9.e4" } ] }, { "id": "7861", "type": "Relation_Trigger", "text": [ "Predicted target" ], "offsets": [ [ 1153, 1169 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d164.s9.e5" } ] }, { "id": "7862", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1366, 1372 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d164.s10.e0" } ] }, { "id": "7863", "type": "Relation_Trigger", "text": [ "targeting" ], "offsets": [ [ 1373, 1382 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d164.s10.e1" } ] }, { "id": "7864", "type": "Diseases", "text": [ "Injury" ], "offsets": [ [ 1437, 1443 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d164.s10.e2" } ] } ]

[]

[]

[ { "id": "7865", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d164.s0.e0", "arg2_id": "miRNA-corp.d164.s0.e1", "normalized": [] }, { "id": "7866", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d164.s1.e1", "arg2_id": "miRNA-corp.d164.s1.e0", "normalized": [] }, { "id": "7867", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d164.s4.e1", "arg2_id": "miRNA-corp.d164.s4.e0", "normalized": [] }, { "id": "7868", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d164.s7.e2", "arg2_id": "miRNA-corp.d164.s7.e0", "normalized": [] }, { "id": "7869", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d164.s7.e2", "arg2_id": "miRNA-corp.d164.s7.e1", "normalized": [] }, { "id": "7870", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d164.s8.e2", "arg2_id": "miRNA-corp.d164.s8.e1", "normalized": [] }, { "id": "7871", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d164.s8.e0", "arg2_id": "miRNA-corp.d164.s8.e1", "normalized": [] }, { "id": "7872", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d164.s9.e1", "arg2_id": "miRNA-corp.d164.s9.e0", "normalized": [] }, { "id": "7873", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d164.s10.e0", "arg2_id": "miRNA-corp.d164.s10.e2", "normalized": [] } ]

[ { "id": "7875", "type": "title", "text": [ "Despite the small sample available, we can show that this approach permits identification of meaningful structures, in particular two polycistronic miRNA genes related to transcriptional activity and likely to be relevant in the discrimination between gliosarcomas and other brain tumors. " ], "offsets": [ [ 0, 289 ] ] }, { "id": "7876", "type": "abstract", "text": [ "Our intention is to identify structures that contain information from both mRNAs and miRNAs, and that can explain the complexity of the data. " ], "offsets": [ [ 290, 432 ] ] }, { "id": "7877", "type": "abstract", "text": [ "Joint analysis of transcriptional and post- transcriptional brain tumor data: searching for emergent properties of cellular systems. " ], "offsets": [ [ 433, 567 ] ] } ]

[ { "id": "7878", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 148, 153 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d165.s0.e0" } ] }, { "id": "7879", "type": "Diseases", "text": [ "gliosarcomas" ], "offsets": [ [ 252, 264 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d165.s0.e1" } ] }, { "id": "7880", "type": "Diseases", "text": [ "brain tumors" ], "offsets": [ [ 275, 287 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d165.s0.e2" } ] }, { "id": "7881", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 375, 381 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d165.s1.e0" } ] }, { "id": "7882", "type": "Diseases", "text": [ "brain tumor" ], "offsets": [ [ 493, 504 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d165.s7.e0" } ] } ]

[]

[]

[ { "id": "7883", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d165.s0.e0", "arg2_id": "miRNA-corp.d165.s0.e1", "normalized": [] }, { "id": "7884", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d165.s0.e0", "arg2_id": "miRNA-corp.d165.s0.e2", "normalized": [] } ]

[ { "id": "7886", "type": "title", "text": [ "To investigate noncoding tiny microRNA mediated gene regulation, miRanda (version 1.0b) was used to predict human miRNA target sites on selected 29 genes related to PD. To verify output generated from miRanda, a similar analysis was performed only for microRNA target sites in 3'UTR using TargetScan (version 5.1). " ], "offsets": [ [ 0, 315 ] ] }, { "id": "7887", "type": "abstract", "text": [ "Data extracted by miRanda elucidates the mode of microRNA action based on the location of target sites in the Parkinson genes. " ], "offsets": [ [ 316, 443 ] ] }, { "id": "7888", "type": "abstract", "text": [ "Sites prone to action of multiple miRNAs were identified as \"hot spots.\" " ], "offsets": [ [ 444, 517 ] ] }, { "id": "7889", "type": "abstract", "text": [ "Important properties of each miRNA including multiplicity and cooperativity appear to contribute towards a complex interplay between miRNAs and their targets. " ], "offsets": [ [ 518, 677 ] ] }, { "id": "7890", "type": "abstract", "text": [ "Two sets of predicted results were explored for the occurrence of target sites of 112 miRNAs expressed in midbrain. " ], "offsets": [ [ 678, 794 ] ] }, { "id": "7891", "type": "abstract", "text": [ "Overall, convergence of results predicted by two algorithms revealed that 48 target sites for midbrain-specific miRNA occur in close proximity in 9 genes. " ], "offsets": [ [ 795, 950 ] ] }, { "id": "7892", "type": "abstract", "text": [ "This study will pave a way for selection of potential miRNA candidates for Parkinson's disease-related genes for quick therapeutic applications and diagnosis. " ], "offsets": [ [ 951, 1112 ] ] }, { "id": "7893", "type": "abstract", "text": [ "Parkinson's disease (PD) is a complex multigenic neurodisorder frequently occurring in elderly persons. " ], "offsets": [ [ 1113, 1217 ] ] }, { "id": "7894", "type": "abstract", "text": [ "Interaction map and selection of microRNA targets in Parkinson's disease-related genes. " ], "offsets": [ [ 1218, 1307 ] ] } ]

[ { "id": "7895", "type": "Non-Specific_miRNAs", "text": [ "microRNA" ], "offsets": [ [ 30, 38 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d166.s0.e0" } ] }, { "id": "7896", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 114, 119 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d166.s0.e1" } ] }, { "id": "7897", "type": "Non-Specific_miRNAs", "text": [ "microRNA" ], "offsets": [ [ 252, 260 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d166.s0.e2" } ] }, { "id": "7898", "type": "Diseases", "text": [ "PD" ], "offsets": [ [ 165, 167 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d166.s0.e3" } ] }, { "id": "7899", "type": "Relation_Trigger", "text": [ "regulation" ], "offsets": [ [ 53, 63 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d166.s0.e4" } ] }, { "id": "7900", "type": "Relation_Trigger", "text": [ "target" ], "offsets": [ [ 120, 126 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d166.s0.e5" } ] }, { "id": "7901", "type": "Relation_Trigger", "text": [ "target" ], "offsets": [ [ 261, 267 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d166.s0.e6" } ] }, { "id": "7902", "type": "Species", "text": [ "human" ], "offsets": [ [ 108, 113 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d166.s0.e7" } ] }, { "id": "7903", "type": "Non-Specific_miRNAs", "text": [ "microRNA" ], "offsets": [ [ 365, 373 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d166.s1.e0" } ] }, { "id": "7904", "type": "Relation_Trigger", "text": [ "target" ], "offsets": [ [ 406, 412 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d166.s1.e1" } ] }, { "id": "7905", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 478, 484 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d166.s2.e0" } ] }, { "id": "7906", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 547, 552 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d166.s3.e0" } ] }, { "id": "7907", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 651, 657 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d166.s3.e1" } ] }, { "id": "7908", "type": "Relation_Trigger", "text": [ "targets" ], "offsets": [ [ 668, 675 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d166.s3.e2" } ] }, { "id": "7909", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 764, 770 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d166.s4.e0" } ] }, { "id": "7910", "type": "Relation_Trigger", "text": [ "target" ], "offsets": [ [ 744, 750 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d166.s4.e1" } ] }, { "id": "7911", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 907, 912 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d166.s5.e0" } ] }, { "id": "7912", "type": "Relation_Trigger", "text": [ "target" ], "offsets": [ [ 872, 878 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d166.s5.e1" } ] }, { "id": "7913", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1005, 1010 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d166.s6.e0" } ] }, { "id": "7914", "type": "Diseases", "text": [ "Parkinson's disease" ], "offsets": [ [ 1026, 1045 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d166.s6.e1" } ] }, { "id": "7915", "type": "Diseases", "text": [ "Parkinson's disease" ], "offsets": [ [ 1113, 1132 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d166.s7.e0" } ] }, { "id": "7916", "type": "Diseases", "text": [ "PD" ], "offsets": [ [ 1134, 1136 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d166.s7.e1" } ] }, { "id": "7917", "type": "Diseases", "text": [ "neurodisorder" ], "offsets": [ [ 1162, 1175 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d166.s7.e2" } ] }, { "id": "7918", "type": "Non-Specific_miRNAs", "text": [ "microRNA" ], "offsets": [ [ 1251, 1259 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d166.s8.e0" } ] }, { "id": "7919", "type": "Relation_Trigger", "text": [ "targets" ], "offsets": [ [ 1260, 1267 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d166.s8.e1" } ] }, { "id": "7920", "type": "Diseases", "text": [ "Parkinson's disease" ], "offsets": [ [ 1271, 1290 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d166.s8.e2" } ] } ]

[]

[]

[ { "id": "7921", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d166.s0.e0", "arg2_id": "miRNA-corp.d166.s0.e3", "normalized": [] }, { "id": "7922", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d166.s0.e1", "arg2_id": "miRNA-corp.d166.s0.e3", "normalized": [] }, { "id": "7923", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d166.s0.e2", "arg2_id": "miRNA-corp.d166.s0.e3", "normalized": [] }, { "id": "7924", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d166.s6.e0", "arg2_id": "miRNA-corp.d166.s6.e1", "normalized": [] }, { "id": "7925", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d166.s8.e0", "arg2_id": "miRNA-corp.d166.s8.e2", "normalized": [] } ]

[ { "id": "7927", "type": "title", "text": [ "These studies suggest that miRNAs may be important for neuronal survival in the context of human neurodegenerative disease. " ], "offsets": [ [ 0, 124 ] ] }, { "id": "7928", "type": "abstract", "text": [ "These studies provide the foundation to define the miRNAs involved in neurodegenerative disease, and the biological pathways affected. " ], "offsets": [ [ 125, 262 ] ] }, { "id": "7929", "type": "abstract", "text": [ "These studies showed that upregulation of ban mitigates degeneration induced by the pathogenic polyglutamine (polyQ) protein Ataxin-3, which is mutated in the human polyglutamine disease spinocerebellar ataxia type 3 (SCA3). " ], "offsets": [ [ 263, 488 ] ] }, { "id": "7930", "type": "abstract", "text": [ "To address the broader role for miRNAs in neuroprotection, we also showed that loss of all miRNAs, by dicer mutation, dramatically enhances pathogenic polyQ protein toxicity in flies and in human HeLa cells. " ], "offsets": [ [ 489, 697 ] ] }, { "id": "7931", "type": "abstract", "text": [ "A new role for microRNA pathways: modulation of degeneration induced by pathogenic human disease proteins. " ], "offsets": [ [ 698, 806 ] ] }, { "id": "7932", "type": "abstract", "text": [ "MicroRNAs (miRNAs) are small noncoding RNAs that regulate the expression of target transcript mRNAs. " ], "offsets": [ [ 807, 908 ] ] }, { "id": "7933", "type": "abstract", "text": [ "Many miRNAs have been defined, however their roles and the processes influenced by miRNA pathways are still being elucidated. " ], "offsets": [ [ 909, 1035 ] ] }, { "id": "7934", "type": "abstract", "text": [ "A role for miRNAs in development and cancer has been described. " ], "offsets": [ [ 1036, 1100 ] ] }, { "id": "7935", "type": "abstract", "text": [ "We recently isolated the miRNA bantam (ban) in a genetic screen for modulators of pathogenicity of a human neurodegenerative disease model in Drosophila. " ], "offsets": [ [ 1101, 1255 ] ] } ]

[ { "id": "7936", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 27, 33 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d167.s0.e0" } ] }, { "id": "7937", "type": "Diseases", "text": [ "neurodegenerative disease" ], "offsets": [ [ 97, 122 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d167.s0.e1" } ] }, { "id": "7938", "type": "Species", "text": [ "human" ], "offsets": [ [ 91, 96 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d167.s0.e2" } ] }, { "id": "7939", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 176, 182 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d167.s1.e0" } ] }, { "id": "7940", "type": "Diseases", "text": [ "neurodegenerative disease" ], "offsets": [ [ 195, 220 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d167.s1.e1" } ] }, { "id": "7941", "type": "Genes/Proteins", "text": [ "Ataxin-3" ], "offsets": [ [ 388, 396 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d167.s2.e0" } ] }, { "id": "7942", "type": "Relation_Trigger", "text": [ "upregulation" ], "offsets": [ [ 289, 301 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d167.s2.e1" } ] }, { "id": "7943", "type": "Diseases", "text": [ "disease spinocerebellar ataxia type 3" ], "offsets": [ [ 442, 479 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d167.s2.e2" } ] }, { "id": "7944", "type": "Diseases", "text": [ "SCA3" ], "offsets": [ [ 481, 485 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d167.s2.e3" } ] }, { "id": "7945", "type": "Species", "text": [ "human" ], "offsets": [ [ 422, 427 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d167.s2.e4" } ] }, { "id": "7946", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 521, 527 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d167.s3.e0" } ] }, { "id": "7947", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 580, 586 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d167.s3.e1" } ] }, { "id": "7948", "type": "Genes/Proteins", "text": [ "dicer" ], "offsets": [ [ 591, 596 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d167.s3.e2" } ] }, { "id": "7949", "type": "Relation_Trigger", "text": [ "loss of all miRNAs" ], "offsets": [ [ 568, 586 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d167.s3.e3" } ] }, { "id": "7950", "type": "Species", "text": [ "human" ], "offsets": [ [ 679, 684 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d167.s3.e4" } ] }, { "id": "7951", "type": "Non-Specific_miRNAs", "text": [ "microRNA" ], "offsets": [ [ 713, 721 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d167.s4.e0" } ] }, { "id": "7952", "type": "Relation_Trigger", "text": [ "modulation" ], "offsets": [ [ 732, 742 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d167.s4.e1" } ] }, { "id": "7953", "type": "Species", "text": [ "human" ], "offsets": [ [ 781, 786 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d167.s4.e2" } ] }, { "id": "7954", "type": "Non-Specific_miRNAs", "text": [ "MicroRNAs" ], "offsets": [ [ 807, 816 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d167.s5.e0" } ] }, { "id": "7955", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 818, 824 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d167.s5.e1" } ] }, { "id": "7956", "type": "Relation_Trigger", "text": [ "target" ], "offsets": [ [ 883, 889 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d167.s5.e2" } ] }, { "id": "7957", "type": "Relation_Trigger", "text": [ "regulate the expression" ], "offsets": [ [ 856, 879 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d167.s5.e3" } ] }, { "id": "7958", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 914, 920 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d167.s6.e0" } ] }, { "id": "7959", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 992, 997 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d167.s6.e1" } ] }, { "id": "7960", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1047, 1053 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d167.s7.e0" } ] }, { "id": "7961", "type": "Diseases", "text": [ "cancer" ], "offsets": [ [ 1073, 1079 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d167.s7.e1" } ] }, { "id": "7962", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1126, 1131 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d167.s8.e0" } ] }, { "id": "7963", "type": "Relation_Trigger", "text": [ "modulators" ], "offsets": [ [ 1169, 1179 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d167.s8.e1" } ] }, { "id": "7964", "type": "Diseases", "text": [ "neurodegenerative disease" ], "offsets": [ [ 1208, 1233 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d167.s8.e2" } ] }, { "id": "7965", "type": "Species", "text": [ "human" ], "offsets": [ [ 1202, 1207 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d167.s8.e3" } ] } ]

[]

[]

[ { "id": "7966", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d167.s0.e0", "arg2_id": "miRNA-corp.d167.s0.e1", "normalized": [] }, { "id": "7967", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d167.s1.e0", "arg2_id": "miRNA-corp.d167.s1.e1", "normalized": [] }, { "id": "7968", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d167.s3.e0", "arg2_id": "miRNA-corp.d167.s3.e2", "normalized": [] }, { "id": "7969", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d167.s3.e1", "arg2_id": "miRNA-corp.d167.s3.e2", "normalized": [] }, { "id": "7970", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d167.s7.e0", "arg2_id": "miRNA-corp.d167.s7.e1", "normalized": [] }, { "id": "7971", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d167.s8.e0", "arg2_id": "miRNA-corp.d167.s8.e2", "normalized": [] } ]

[ { "id": "7973", "type": "title", "text": [ "CONCLUSIONS/SIGNIFICANCE: We provide a list of ten miRNA loci potentially involved in the development of blood cancer or brain tumors. " ], "offsets": [ [ 0, 135 ] ] }, { "id": "7974", "type": "abstract", "text": [ "There is independent experimental support from other studies for the involvement of miRNAs from at least three CIS-associated miRNA loci in cancer development. " ], "offsets": [ [ 136, 298 ] ] }, { "id": "7975", "type": "abstract", "text": [ "CIS-associated miRNAs on average are more conserved in vertebrates than miRNAs associated with non-CIS inserts and their human homologs are also located in regions perturbed in cancer. " ], "offsets": [ [ 299, 484 ] ] }, { "id": "7976", "type": "abstract", "text": [ "In addition we show that miRNA genes are enriched around promoter and/or terminator regions of RefSeq genes in both mouse and human. " ], "offsets": [ [ 485, 618 ] ] }, { "id": "7977", "type": "abstract", "text": [ "Ten CIS-associated miRNA loci containing 22 miRNAs are located within 10 kb of known CIS insertions. " ], "offsets": [ [ 619, 720 ] ] }, { "id": "7978", "type": "abstract", "text": [ "Only one CIS-associated miRNA locus overlaps a RefSeq protein-coding gene and six loci are located more than 10 kb from any RefSeq gene. " ], "offsets": [ [ 721, 858 ] ] }, { "id": "7979", "type": "abstract", "text": [ "METHODOLOGY/PRINCIPAL FINDINGS: Using a public database of mapped retroviral insertion sites from various mouse models of cancer we demonstrate that MLV-derived retroviral inserts are enriched in close proximity to mouse miRNA loci. " ], "offsets": [ [ 859, 1092 ] ] }, { "id": "7980", "type": "abstract", "text": [ "Clustered inserts from cancer-associated regions (Common Integration Sites, CIS) have a higher association with miRNAs than non-clustered inserts. " ], "offsets": [ [ 1093, 1240 ] ] }, { "id": "7981", "type": "abstract", "text": [ "BACKGROUND: MicroRNAs (miRNAs) are short non-coding RNAs that regulate differentiation and development in many organisms and play an important role in cancer. " ], "offsets": [ [ 1241, 1400 ] ] }, { "id": "7982", "type": "abstract", "text": [ "Orthologous microRNA genes are located in cancer-associated genomic regions in human and mouse. " ], "offsets": [ [ 1401, 1498 ] ] } ]

[ { "id": "7983", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 51, 56 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d168.s0.e0" } ] }, { "id": "7984", "type": "Diseases", "text": [ "brain tumors" ], "offsets": [ [ 121, 133 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d168.s0.e1" } ] }, { "id": "7985", "type": "Diseases", "text": [ "cancer" ], "offsets": [ [ 111, 117 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d168.s0.e2" } ] }, { "id": "7986", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 262, 267 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d168.s1.e0" } ] }, { "id": "7987", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 220, 226 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d168.s1.e1" } ] }, { "id": "7988", "type": "Diseases", "text": [ "cancer" ], "offsets": [ [ 276, 282 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d168.s1.e2" } ] }, { "id": "7989", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 314, 320 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d168.s2.e0" } ] }, { "id": "7990", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 371, 377 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d168.s2.e1" } ] }, { "id": "7991", "type": "Relation_Trigger", "text": [ "associated" ], "offsets": [ [ 378, 388 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d168.s2.e2" } ] }, { "id": "7992", "type": "Diseases", "text": [ "cancer" ], "offsets": [ [ 476, 482 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d168.s2.e3" } ] }, { "id": "7993", "type": "Species", "text": [ "human" ], "offsets": [ [ 420, 425 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d168.s2.e4" } ] }, { "id": "7994", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 510, 515 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d168.s3.e0" } ] }, { "id": "7995", "type": "Species", "text": [ "mouse" ], "offsets": [ [ 601, 606 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d168.s3.e1" } ] }, { "id": "7996", "type": "Species", "text": [ "human" ], "offsets": [ [ 611, 616 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d168.s3.e2" } ] }, { "id": "7997", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 638, 643 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d168.s4.e0" } ] }, { "id": "7998", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 663, 669 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d168.s4.e1" } ] }, { "id": "7999", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 745, 750 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d168.s5.e0" } ] }, { "id": "8000", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1080, 1085 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d168.s6.e0" } ] }, { "id": "8001", "type": "Diseases", "text": [ "cancer" ], "offsets": [ [ 981, 987 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d168.s6.e1" } ] }, { "id": "8002", "type": "Species", "text": [ "mouse" ], "offsets": [ [ 965, 970 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d168.s6.e2" } ] }, { "id": "8003", "type": "Species", "text": [ "mouse" ], "offsets": [ [ 1074, 1079 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d168.s6.e3" } ] }, { "id": "8004", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1205, 1211 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d168.s7.e0" } ] }, { "id": "8005", "type": "Relation_Trigger", "text": [ "higher association" ], "offsets": [ [ 1181, 1199 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d168.s7.e1" } ] }, { "id": "8006", "type": "Diseases", "text": [ "cancer" ], "offsets": [ [ 1116, 1122 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d168.s7.e2" } ] }, { "id": "8007", "type": "Non-Specific_miRNAs", "text": [ "MicroRNAs" ], "offsets": [ [ 1253, 1262 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d168.s8.e0" } ] }, { "id": "8008", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1264, 1270 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d168.s8.e1" } ] }, { "id": "8009", "type": "Relation_Trigger", "text": [ "regulate" ], "offsets": [ [ 1303, 1311 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d168.s8.e2" } ] }, { "id": "8010", "type": "Diseases", "text": [ "cancer" ], "offsets": [ [ 1392, 1398 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d168.s8.e3" } ] }, { "id": "8011", "type": "Non-Specific_miRNAs", "text": [ "microRNA" ], "offsets": [ [ 1413, 1421 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d168.s9.e0" } ] }, { "id": "8012", "type": "Diseases", "text": [ "cancer" ], "offsets": [ [ 1443, 1449 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d168.s9.e1" } ] }, { "id": "8013", "type": "Species", "text": [ "human" ], "offsets": [ [ 1480, 1485 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d168.s9.e2" } ] }, { "id": "8014", "type": "Species", "text": [ "mouse" ], "offsets": [ [ 1490, 1495 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d168.s9.e3" } ] } ]

[]

[]

[ { "id": "8015", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d168.s0.e0", "arg2_id": "miRNA-corp.d168.s0.e1", "normalized": [] }, { "id": "8016", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d168.s0.e0", "arg2_id": "miRNA-corp.d168.s0.e2", "normalized": [] }, { "id": "8017", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d168.s1.e0", "arg2_id": "miRNA-corp.d168.s1.e2", "normalized": [] }, { "id": "8018", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d168.s1.e1", "arg2_id": "miRNA-corp.d168.s1.e2", "normalized": [] }, { "id": "8019", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d168.s2.e0", "arg2_id": "miRNA-corp.d168.s2.e3", "normalized": [] }, { "id": "8020", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d168.s2.e1", "arg2_id": "miRNA-corp.d168.s2.e3", "normalized": [] }, { "id": "8021", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d168.s6.e0", "arg2_id": "miRNA-corp.d168.s6.e1", "normalized": [] }, { "id": "8022", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d168.s7.e0", "arg2_id": "miRNA-corp.d168.s7.e2", "normalized": [] }, { "id": "8023", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d168.s8.e0", "arg2_id": "miRNA-corp.d168.s8.e3", "normalized": [] }, { "id": "8024", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d168.s8.e1", "arg2_id": "miRNA-corp.d168.s8.e3", "normalized": [] }, { "id": "8025", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d168.s9.e0", "arg2_id": "miRNA-corp.d168.s9.e1", "normalized": [] } ]

[ { "id": "8027", "type": "title", "text": [ "MicroRNA expression in ACTH-producing pituitary tumors: up-regulation of microRNA-122 and -493 in pituitary carcinomas. " ], "offsets": [ [ 0, 121 ] ] }, { "id": "8028", "type": "abstract", "text": [ "Real-time RT-PCR and in situ hybridization were used to confirm and independently validate miRNAs that were significantly up-regulated or down-regulated between the pituitary tissues. " ], "offsets": [ [ 122, 306 ] ] }, { "id": "8029", "type": "abstract", "text": [ "We used miRNA profiling with 1,145 probes to study miRNA expression in normal anterior pituitary (6 cases), adrenocorticotropin (ACTH)-producing adenomas (8 cases), and ACTH-producing pituitary carcinomas (two cases). " ], "offsets": [ [ 307, 525 ] ] }, { "id": "8030", "type": "abstract", "text": [ "The expression of miRNAs in pituitary carcinomas has not been previously examined. " ], "offsets": [ [ 526, 609 ] ] }, { "id": "8031", "type": "abstract", "text": [ "MicroRNAs (miRNAs) are involved in cell proliferation, differentiation, and apoptosis, and can function as tumor suppressor genes or oncogenes. " ], "offsets": [ [ 610, 754 ] ] }, { "id": "8032", "type": "abstract", "text": [ "MiRNA-493 was also up-regulated in carcinomas compared to ACTH adenomas. " ], "offsets": [ [ 755, 828 ] ] }, { "id": "8033", "type": "abstract", "text": [ "Analysis of genes that miRNA-493 interacts with included LGALS3 and RUNX2 ( http://microrna.sanger.ac.uk ) both of which have been shown to have roles in pituitary tumor cell growth. " ], "offsets": [ [ 829, 1012 ] ] }, { "id": "8034", "type": "abstract", "text": [ "There were more miRNAs up- (188) or down-regulated (160) between adenomas and normal pituitaries compared to carcinomas and normal pituitaries (92 up- and 91 down-regulated) or between carcinomas and adenomas (46 up- and 52 down-regulated). " ], "offsets": [ [ 1013, 1254 ] ] }, { "id": "8035", "type": "abstract", "text": [ "Both real-time RT-PCR and in situ hybridization showed significant up-regulation of miRNA-122 between pituitary carcinomas and adenomas. " ], "offsets": [ [ 1255, 1392 ] ] }, { "id": "8036", "type": "abstract", "text": [ "These results provide information about marker miRNAs that may lead to further insights into the regulation of pituitary tumor growth and development. " ], "offsets": [ [ 1393, 1546 ] ] } ]

[ { "id": "8037", "type": "Non-Specific_miRNAs", "text": [ "MicroRNA" ], "offsets": [ [ 0, 8 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d169.s0.e0" } ] }, { "id": "8038", "type": "Diseases", "text": [ "pituitary tumors" ], "offsets": [ [ 38, 54 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d169.s0.e1" } ] }, { "id": "8039", "type": "Diseases", "text": [ "pituitary carcinomas" ], "offsets": [ [ 98, 118 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d169.s0.e2" } ] }, { "id": "8040", "type": "Specific_miRNAs", "text": [ "microRNA-122 and -493" ], "offsets": [ [ 73, 94 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d169.s0.e3" } ] }, { "id": "8041", "type": "Relation_Trigger", "text": [ "up-regulation" ], "offsets": [ [ 56, 69 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d169.s0.e4" } ] }, { "id": "8042", "type": "Genes/Proteins", "text": [ "ACTH" ], "offsets": [ [ 23, 27 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d169.s0.e5" } ] }, { "id": "8043", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 213, 219 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d169.s1.e0" } ] }, { "id": "8044", "type": "Relation_Trigger", "text": [ "down-regulated" ], "offsets": [ [ 260, 274 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d169.s1.e1" } ] }, { "id": "8045", "type": "Relation_Trigger", "text": [ "up-regulated" ], "offsets": [ [ 244, 256 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d169.s1.e2" } ] }, { "id": "8046", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 315, 320 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d169.s2.e0" } ] }, { "id": "8047", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 358, 363 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d169.s2.e1" } ] }, { "id": "8048", "type": "Diseases", "text": [ "pituitary carcinomas" ], "offsets": [ [ 491, 511 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d169.s2.e2" } ] }, { "id": "8049", "type": "Diseases", "text": [ "adenomas" ], "offsets": [ [ 452, 460 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d169.s2.e3" } ] }, { "id": "8050", "type": "Genes/Proteins", "text": [ "ACTH" ], "offsets": [ [ 436, 440 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d169.s2.e4" } ] }, { "id": "8051", "type": "Genes/Proteins", "text": [ "adrenocorticotropin" ], "offsets": [ [ 415, 434 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d169.s2.e5" } ] }, { "id": "8052", "type": "Genes/Proteins", "text": [ "ACTH" ], "offsets": [ [ 476, 480 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d169.s2.e6" } ] }, { "id": "8053", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 544, 550 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d169.s3.e0" } ] }, { "id": "8054", "type": "Diseases", "text": [ "pituitary carcinomas" ], "offsets": [ [ 554, 574 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d169.s3.e1" } ] }, { "id": "8055", "type": "Non-Specific_miRNAs", "text": [ "MicroRNAs" ], "offsets": [ [ 610, 619 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d169.s4.e0" } ] }, { "id": "8056", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 621, 627 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d169.s4.e1" } ] }, { "id": "8057", "type": "Relation_Trigger", "text": [ "tumor suppressor" ], "offsets": [ [ 717, 733 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d169.s4.e2" } ] }, { "id": "8058", "type": "Relation_Trigger", "text": [ "up-regulated" ], "offsets": [ [ 774, 786 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d169.s5.e0" } ] }, { "id": "8059", "type": "Specific_miRNAs", "text": [ "MiRNA-493" ], "offsets": [ [ 755, 764 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d169.s5.e1" } ] }, { "id": "8060", "type": "Genes/Proteins", "text": [ "ACTH" ], "offsets": [ [ 813, 817 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d169.s5.e2" } ] }, { "id": "8061", "type": "Diseases", "text": [ "adenomas" ], "offsets": [ [ 818, 826 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d169.s5.e3" } ] }, { "id": "8062", "type": "Diseases", "text": [ "carcinomas" ], "offsets": [ [ 790, 800 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d169.s5.e4" } ] }, { "id": "8063", "type": "Diseases", "text": [ "pituitary tumor" ], "offsets": [ [ 983, 998 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d169.s6.e0" } ] }, { "id": "8064", "type": "Specific_miRNAs", "text": [ "miRNA-493" ], "offsets": [ [ 852, 861 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d169.s6.e1" } ] }, { "id": "8065", "type": "Genes/Proteins", "text": [ "LGALS3" ], "offsets": [ [ 886, 892 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d169.s6.e2" } ] }, { "id": "8066", "type": "Genes/Proteins", "text": [ "RUNX2" ], "offsets": [ [ 897, 902 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d169.s6.e3" } ] }, { "id": "8067", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1029, 1035 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d169.s7.e0" } ] }, { "id": "8068", "type": "Relation_Trigger", "text": [ "down-regulated" ], "offsets": [ [ 1049, 1063 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d169.s7.e1" } ] }, { "id": "8069", "type": "Relation_Trigger", "text": [ "down-regulated" ], "offsets": [ [ 1171, 1185 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d169.s7.e2" } ] }, { "id": "8070", "type": "Relation_Trigger", "text": [ "down-regulated" ], "offsets": [ [ 1237, 1251 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d169.s7.e3" } ] }, { "id": "8071", "type": "Diseases", "text": [ "adenomas" ], "offsets": [ [ 1078, 1086 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d169.s7.e4" } ] }, { "id": "8072", "type": "Diseases", "text": [ "adenomas" ], "offsets": [ [ 1213, 1221 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d169.s7.e5" } ] }, { "id": "8073", "type": "Diseases", "text": [ "carcinomas" ], "offsets": [ [ 1122, 1132 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d169.s7.e6" } ] }, { "id": "8074", "type": "Diseases", "text": [ "carcinomas" ], "offsets": [ [ 1198, 1208 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d169.s7.e7" } ] }, { "id": "8075", "type": "Diseases", "text": [ "pituitary carcinomas" ], "offsets": [ [ 1357, 1377 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d169.s8.e0" } ] }, { "id": "8076", "type": "Relation_Trigger", "text": [ "up-regulation" ], "offsets": [ [ 1322, 1335 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d169.s8.e1" } ] }, { "id": "8077", "type": "Specific_miRNAs", "text": [ "miRNA-122" ], "offsets": [ [ 1339, 1348 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d169.s8.e2" } ] }, { "id": "8078", "type": "Diseases", "text": [ "adenomas" ], "offsets": [ [ 1382, 1390 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d169.s8.e3" } ] }, { "id": "8079", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1440, 1446 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d169.s9.e0" } ] }, { "id": "8080", "type": "Diseases", "text": [ "pituitary tumor" ], "offsets": [ [ 1504, 1519 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d169.s9.e1" } ] }, { "id": "8081", "type": "Relation_Trigger", "text": [ "regulation" ], "offsets": [ [ 1490, 1500 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d169.s9.e2" } ] } ]

[]

[]

[ { "id": "8082", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d169.s0.e0", "arg2_id": "miRNA-corp.d169.s0.e2", "normalized": [] }, { "id": "8083", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d169.s0.e0", "arg2_id": "miRNA-corp.d169.s0.e5", "normalized": [] }, { "id": "8084", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d169.s0.e0", "arg2_id": "miRNA-corp.d169.s0.e1", "normalized": [] }, { "id": "8085", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d169.s0.e3", "arg2_id": "miRNA-corp.d169.s0.e2", "normalized": [] }, { "id": "8086", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d169.s0.e3", "arg2_id": "miRNA-corp.d169.s0.e5", "normalized": [] }, { "id": "8087", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d169.s0.e3", "arg2_id": "miRNA-corp.d169.s0.e1", "normalized": [] }, { "id": "8088", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d169.s2.e0", "arg2_id": "miRNA-corp.d169.s2.e2", "normalized": [] }, { "id": "8089", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d169.s2.e0", "arg2_id": "miRNA-corp.d169.s2.e3", "normalized": [] }, { "id": "8090", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d169.s2.e0", "arg2_id": "miRNA-corp.d169.s2.e4", "normalized": [] }, { "id": "8091", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d169.s2.e0", "arg2_id": "miRNA-corp.d169.s2.e5", "normalized": [] }, { "id": "8092", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d169.s2.e0", "arg2_id": "miRNA-corp.d169.s2.e6", "normalized": [] }, { "id": "8093", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d169.s2.e1", "arg2_id": "miRNA-corp.d169.s2.e2", "normalized": [] }, { "id": "8094", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d169.s2.e1", "arg2_id": "miRNA-corp.d169.s2.e3", "normalized": [] }, { "id": "8095", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d169.s2.e1", "arg2_id": "miRNA-corp.d169.s2.e4", "normalized": [] }, { "id": "8096", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d169.s2.e1", "arg2_id": "miRNA-corp.d169.s2.e5", "normalized": [] }, { "id": "8097", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d169.s2.e1", "arg2_id": "miRNA-corp.d169.s2.e6", "normalized": [] }, { "id": "8098", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d169.s3.e0", "arg2_id": "miRNA-corp.d169.s3.e1", "normalized": [] }, { "id": "8099", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d169.s5.e1", "arg2_id": "miRNA-corp.d169.s5.e2", "normalized": [] }, { "id": "8100", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d169.s5.e1", "arg2_id": "miRNA-corp.d169.s5.e3", "normalized": [] }, { "id": "8101", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d169.s5.e1", "arg2_id": "miRNA-corp.d169.s5.e4", "normalized": [] }, { "id": "8102", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d169.s6.e1", "arg2_id": "miRNA-corp.d169.s6.e0", "normalized": [] }, { "id": "8103", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d169.s6.e1", "arg2_id": "miRNA-corp.d169.s6.e2", "normalized": [] }, { "id": "8104", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d169.s6.e1", "arg2_id": "miRNA-corp.d169.s6.e3", "normalized": [] }, { "id": "8105", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d169.s7.e0", "arg2_id": "miRNA-corp.d169.s7.e4", "normalized": [] }, { "id": "8106", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d169.s7.e0", "arg2_id": "miRNA-corp.d169.s7.e5", "normalized": [] }, { "id": "8107", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d169.s7.e0", "arg2_id": "miRNA-corp.d169.s7.e6", "normalized": [] }, { "id": "8108", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d169.s7.e0", "arg2_id": "miRNA-corp.d169.s7.e7", "normalized": [] }, { "id": "8109", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d169.s8.e2", "arg2_id": "miRNA-corp.d169.s8.e0", "normalized": [] }, { "id": "8110", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d169.s8.e2", "arg2_id": "miRNA-corp.d169.s8.e3", "normalized": [] }, { "id": "8111", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d169.s9.e0", "arg2_id": "miRNA-corp.d169.s9.e1", "normalized": [] } ]

[ { "id": "8113", "type": "title", "text": [ "METHODS: Surgical outcome data were prospectively collected for 2 to 11 years in 161 consecutive patients with MTLE/ HS. Eighty patients underwent an ATL and 81 an SA. Seizure control achieved with each technique was compared using the Engel classification scheme. " ], "offsets": [ [ 0, 265 ] ] }, { "id": "8114", "type": "abstract", "text": [ "Postoperative memory testing was performed in 86 patients (53%). " ], "offsets": [ [ 266, 331 ] ] }, { "id": "8115", "type": "abstract", "text": [ "At the last follow up, 72% of the patients who had undergone an ATL (mean follow up 6.7 years) and 71% of those who had undergone an SA (mean follow up 4.5 years) were seizure free (Engle Class IA). " ], "offsets": [ [ 332, 531 ] ] }, { "id": "8116", "type": "abstract", "text": [ "Estimated survival in patients in Engel Classes I, IA, and I and II combined did not differ between the two surgical techniques. " ], "offsets": [ [ 532, 661 ] ] }, { "id": "8117", "type": "abstract", "text": [ "Preoperatively, 58% of the patients had verbal memory scores one standard deviation (SD) below the normal mean. " ], "offsets": [ [ 662, 774 ] ] }, { "id": "8118", "type": "abstract", "text": [ "One third of the patients with preoperative scores in the normal range worsened after surgery, although this outcome was not related to the surgical technique. " ], "offsets": [ [ 775, 935 ] ] }, { "id": "8119", "type": "abstract", "text": [ "Nine (18%) of the 50 patients whose left side had been surgically treated improved their verbal memory scores by more than one SD. Seven (78%) of these nine underwent an SA (p = 0.05). " ], "offsets": [ [ 936, 1121 ] ] }, { "id": "8120", "type": "abstract", "text": [ "OBJECT: The aim of this study was to compare seizure and memory outcome in patients with medically refractory mesial temporal lobe epilepsy due to hippocampal sclerosis (MTLE/HS) treated using an anterior temporal lobectomy (ATL) or a selective amygdalohippocampectomy (SA). " ], "offsets": [ [ 1122, 1397 ] ] }, { "id": "8121", "type": "abstract", "text": [ "Seizure and memory outcome following temporal lobe surgery: selective compared with nonselective approaches for hippocampal sclerosis. " ], "offsets": [ [ 1398, 1534 ] ] }, { "id": "8122", "type": "abstract", "text": [ "Preliminary data suggest that postoperative verbal memory scores may improve in patients who undergo selective resection of a sclerotic hippocampus in the dominant temporal lobe. " ], "offsets": [ [ 1535, 1716 ] ] }, { "id": "8123", "type": "abstract", "text": [ "CONCLUSIONS: Both ATL and SA can lead to similar favorable seizure control in patients with MTLE/HS. " ], "offsets": [ [ 1717, 1818 ] ] } ]

[ { "id": "8124", "type": "Diseases", "text": [ "MTLE" ], "offsets": [ [ 111, 115 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d170.s0.e0" } ] }, { "id": "8125", "type": "Diseases", "text": [ "HS" ], "offsets": [ [ 117, 119 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d170.s0.e1" } ] }, { "id": "8126", "type": "Diseases", "text": [ "Seizure" ], "offsets": [ [ 168, 175 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d170.s0.e2" } ] }, { "id": "8127", "type": "Species", "text": [ "patients" ], "offsets": [ [ 128, 136 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d170.s0.e3" } ] }, { "id": "8128", "type": "Species", "text": [ "patients" ], "offsets": [ [ 97, 105 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d170.s0.e4" } ] }, { "id": "8129", "type": "Species", "text": [ "patients" ], "offsets": [ [ 315, 323 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d170.s1.e0" } ] }, { "id": "8130", "type": "Diseases", "text": [ "seizure" ], "offsets": [ [ 500, 507 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d170.s2.e0" } ] }, { "id": "8131", "type": "Species", "text": [ "patients" ], "offsets": [ [ 366, 374 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d170.s2.e1" } ] }, { "id": "8132", "type": "Species", "text": [ "patients" ], "offsets": [ [ 554, 562 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d170.s3.e0" } ] }, { "id": "8133", "type": "Species", "text": [ "patients" ], "offsets": [ [ 689, 697 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d170.s4.e0" } ] }, { "id": "8134", "type": "Species", "text": [ "patients" ], "offsets": [ [ 792, 800 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d170.s5.e0" } ] }, { "id": "8135", "type": "Species", "text": [ "patients" ], "offsets": [ [ 957, 965 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d170.s7.e0" } ] }, { "id": "8136", "type": "Diseases", "text": [ "seizure" ], "offsets": [ [ 1167, 1174 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d170.s8.e0" } ] }, { "id": "8137", "type": "Diseases", "text": [ "mesial temporal lobe epilepsy" ], "offsets": [ [ 1232, 1261 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d170.s8.e1" } ] }, { "id": "8138", "type": "Diseases", "text": [ "hippocampal sclerosis" ], "offsets": [ [ 1269, 1290 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d170.s8.e2" } ] }, { "id": "8139", "type": "Diseases", "text": [ "MTLE" ], "offsets": [ [ 1292, 1296 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d170.s8.e3" } ] }, { "id": "8140", "type": "Diseases", "text": [ "HS" ], "offsets": [ [ 1297, 1299 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d170.s8.e4" } ] }, { "id": "8141", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1197, 1205 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d170.s8.e5" } ] }, { "id": "8142", "type": "Diseases", "text": [ "Seizure" ], "offsets": [ [ 1398, 1405 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d170.s9.e0" } ] }, { "id": "8143", "type": "Diseases", "text": [ "hippocampal sclerosis" ], "offsets": [ [ 1510, 1531 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d170.s9.e1" } ] }, { "id": "8144", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1615, 1623 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d170.s10.e0" } ] }, { "id": "8145", "type": "Diseases", "text": [ "seizure" ], "offsets": [ [ 1776, 1783 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d170.s11.e0" } ] }, { "id": "8146", "type": "Diseases", "text": [ "MTLE" ], "offsets": [ [ 1809, 1813 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d170.s11.e1" } ] }, { "id": "8147", "type": "Diseases", "text": [ "HS" ], "offsets": [ [ 1814, 1816 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d170.s11.e2" } ] }, { "id": "8148", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1795, 1803 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d170.s11.e3" } ] } ]

[]

[]

[]

[ { "id": "8150", "type": "abstract", "text": [ "METHOD: A consecutive series of 40 patients who underwent microsurgical clipping for UIA were studied. " ], "offsets": [ [ 0, 103 ] ] }, { "id": "8151", "type": "abstract", "text": [ "Microsurgical clipping in forty patients with unruptured anterior cerebral circulation aneurysms: an investigation into cognitive outcome. " ], "offsets": [ [ 104, 244 ] ] }, { "id": "8152", "type": "abstract", "text": [ "OBJECTIVE: It is a consensus that most unruptured intracranial aneurysms (UIA) can be treated with acceptably low morbidity. " ], "offsets": [ [ 245, 370 ] ] }, { "id": "8153", "type": "abstract", "text": [ "However, some studies recently reported postoperative cognitive impairment, suggesting that it could be attributable to surgical damage. " ], "offsets": [ [ 371, 508 ] ] }, { "id": "8154", "type": "abstract", "text": [ "Our goal is to evaluate cognitive function before and after microsurgical clipping in patients with UIA. " ], "offsets": [ [ 509, 614 ] ] }, { "id": "8155", "type": "abstract", "text": [ "ANOVA did not find independent associations between MMSE scores and age, hypertension, smoking, dyslipidemia, education, aneurysm location, number, laterality or size. " ], "offsets": [ [ 615, 783 ] ] }, { "id": "8156", "type": "abstract", "text": [ "CONCLUSION: The present study suggests that microsurgical clipping for UIA does not result in major cognitive dysfunction as determined by the MMSE. " ], "offsets": [ [ 784, 935 ] ] } ]

[ { "id": "8157", "type": "Species", "text": [ "patients" ], "offsets": [ [ 35, 43 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d171.s2.e0" } ] }, { "id": "8158", "type": "Diseases", "text": [ "aneurysms" ], "offsets": [ [ 191, 200 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d171.s6.e0" } ] }, { "id": "8159", "type": "Species", "text": [ "patients" ], "offsets": [ [ 136, 144 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d171.s6.e1" } ] }, { "id": "8160", "type": "Diseases", "text": [ "intracranial aneurysms" ], "offsets": [ [ 295, 317 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d171.s7.e0" } ] }, { "id": "8161", "type": "Diseases", "text": [ "cognitive impairment" ], "offsets": [ [ 425, 445 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d171.s8.e0" } ] }, { "id": "8162", "type": "Species", "text": [ "patients" ], "offsets": [ [ 595, 603 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d171.s9.e0" } ] }, { "id": "8163", "type": "Relation_Trigger", "text": [ "associations" ], "offsets": [ [ 646, 658 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d171.s10.e0" } ] }, { "id": "8164", "type": "Diseases", "text": [ "aneurysm" ], "offsets": [ [ 736, 744 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d171.s10.e1" } ] }, { "id": "8165", "type": "Diseases", "text": [ "dyslipidemia" ], "offsets": [ [ 711, 723 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d171.s10.e2" } ] }, { "id": "8166", "type": "Diseases", "text": [ "hypertension" ], "offsets": [ [ 688, 700 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d171.s10.e3" } ] }, { "id": "8167", "type": "Diseases", "text": [ "hypertension" ], "offsets": [ [ 688, 700 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d171.s10.e4" } ] }, { "id": "8168", "type": "Diseases", "text": [ "cognitive dysfunction" ], "offsets": [ [ 884, 905 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d171.s11.e0" } ] } ]

[]

[]

[]

[ { "id": "8170", "type": "title", "text": [ "MicroRNA miR-133b is essential for functional recovery after spinal cord injury in adult zebrafish. " ], "offsets": [ [ 0, 101 ] ] }, { "id": "8171", "type": "abstract", "text": [ "MicroRNAs (miRNAs) play important roles during development and also in adult organisms by regulating the expression of multiple target genes. " ], "offsets": [ [ 102, 244 ] ] }, { "id": "8172", "type": "abstract", "text": [ "Here, we studied the function of miR-133b during zebrafish spinal cord regeneration and show upregulation of miR-133b expression in regenerating neurons of the brainstem after transection of the spinal cord. " ], "offsets": [ [ 245, 453 ] ] }, { "id": "8173", "type": "abstract", "text": [ "miR-133b has been shown to promote tissue regeneration in other tissue, but its ability to do so in the nervous system has yet to be tested. " ], "offsets": [ [ 454, 595 ] ] }, { "id": "8174", "type": "abstract", "text": [ "Inhibition of miR-133b expression by antisense morpholino (MO) application resulted in impaired locomotor recovery and reduced regeneration of axons from neurons in the nucleus of the medial longitudinal fascicle, superior reticular formation and intermediate reticular formation. " ], "offsets": [ [ 596, 877 ] ] }, { "id": "8175", "type": "abstract", "text": [ "miR-133b targets the small GTPase RhoA, which is an inhibitor of axonal growth, as well as other neurite outgrowth-related molecules. " ], "offsets": [ [ 878, 1012 ] ] }, { "id": "8176", "type": "abstract", "text": [ "Our results indicate that miR-133b is an important determinant in spinal cord regeneration of adult zebrafish through reduction in RhoA protein levels by direct interaction with its mRNA. " ], "offsets": [ [ 1013, 1201 ] ] }, { "id": "8177", "type": "abstract", "text": [ "While RhoA has been studied as a therapeutic target in spinal cord injury, this is the first demonstration of endogenous regulation of RhoA by a microRNA that is required for spinal cord regeneration in zebrafish. " ], "offsets": [ [ 1202, 1416 ] ] }, { "id": "8178", "type": "abstract", "text": [ "The ability of miR-133b to suppress molecules that inhibit axon regrowth may underlie the capacity for adult zebrafish to recover locomotor function after spinal cord injury. " ], "offsets": [ [ 1417, 1594 ] ] } ]

[ { "id": "8179", "type": "Diseases", "text": [ "spinal cord injury" ], "offsets": [ [ 61, 79 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d172.s0.e0" } ] }, { "id": "8180", "type": "Non-Specific_miRNAs", "text": [ "MicroRNA" ], "offsets": [ [ 0, 8 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d172.s0.e1" } ] }, { "id": "8181", "type": "Specific_miRNAs", "text": [ "miR-133b" ], "offsets": [ [ 9, 17 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d172.s0.e2" } ] }, { "id": "8182", "type": "Species", "text": [ "zebrafish" ], "offsets": [ [ 89, 98 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d172.s0.e3" } ] }, { "id": "8183", "type": "Non-Specific_miRNAs", "text": [ "MicroRNAs" ], "offsets": [ [ 102, 111 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d172.s1.e0" } ] }, { "id": "8184", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 113, 119 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d172.s1.e1" } ] }, { "id": "8185", "type": "Relation_Trigger", "text": [ "regulating the expression" ], "offsets": [ [ 192, 217 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d172.s1.e2" } ] }, { "id": "8186", "type": "Relation_Trigger", "text": [ "target" ], "offsets": [ [ 230, 236 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d172.s1.e3" } ] }, { "id": "8187", "type": "Relation_Trigger", "text": [ "upregulation of miR-133b expression" ], "offsets": [ [ 338, 373 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d172.s2.e0" } ] }, { "id": "8188", "type": "Specific_miRNAs", "text": [ "miR-133b" ], "offsets": [ [ 278, 286 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d172.s2.e1" } ] }, { "id": "8189", "type": "Specific_miRNAs", "text": [ "miR-133b" ], "offsets": [ [ 354, 362 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d172.s2.e2" } ] }, { "id": "8190", "type": "Species", "text": [ "zebrafish" ], "offsets": [ [ 294, 303 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d172.s2.e3" } ] }, { "id": "8191", "type": "Specific_miRNAs", "text": [ "miR-133b" ], "offsets": [ [ 454, 462 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d172.s3.e0" } ] }, { "id": "8192", "type": "Relation_Trigger", "text": [ "Inhibition of miR-133b expression" ], "offsets": [ [ 596, 629 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d172.s4.e0" } ] }, { "id": "8193", "type": "Specific_miRNAs", "text": [ "miR-133b" ], "offsets": [ [ 610, 618 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d172.s4.e1" } ] }, { "id": "8194", "type": "Genes/Proteins", "text": [ "RhoA" ], "offsets": [ [ 912, 916 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d172.s5.e0" } ] }, { "id": "8195", "type": "Relation_Trigger", "text": [ "targets" ], "offsets": [ [ 887, 894 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d172.s5.e1" } ] }, { "id": "8196", "type": "Specific_miRNAs", "text": [ "miR-133b" ], "offsets": [ [ 878, 886 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d172.s5.e2" } ] }, { "id": "8197", "type": "Relation_Trigger", "text": [ "inhibitor" ], "offsets": [ [ 930, 939 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d172.s5.e3" } ] }, { "id": "8198", "type": "Genes/Proteins", "text": [ "RhoA" ], "offsets": [ [ 1144, 1148 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d172.s6.e0" } ] }, { "id": "8199", "type": "Relation_Trigger", "text": [ "reduction in RhoA protein levels" ], "offsets": [ [ 1131, 1163 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d172.s6.e1" } ] }, { "id": "8200", "type": "Specific_miRNAs", "text": [ "miR-133b" ], "offsets": [ [ 1039, 1047 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d172.s6.e2" } ] }, { "id": "8201", "type": "Species", "text": [ "zebrafish" ], "offsets": [ [ 1113, 1122 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d172.s6.e3" } ] }, { "id": "8202", "type": "Diseases", "text": [ "spinal cord injury" ], "offsets": [ [ 1257, 1275 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d172.s7.e0" } ] }, { "id": "8203", "type": "Genes/Proteins", "text": [ "RhoA" ], "offsets": [ [ 1208, 1212 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d172.s7.e1" } ] }, { "id": "8204", "type": "Genes/Proteins", "text": [ "RhoA" ], "offsets": [ [ 1337, 1341 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d172.s7.e2" } ] }, { "id": "8205", "type": "Non-Specific_miRNAs", "text": [ "microRNA" ], "offsets": [ [ 1347, 1355 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d172.s7.e3" } ] }, { "id": "8206", "type": "Relation_Trigger", "text": [ "therapeutic target" ], "offsets": [ [ 1235, 1253 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d172.s7.e4" } ] }, { "id": "8207", "type": "Relation_Trigger", "text": [ "regulation" ], "offsets": [ [ 1323, 1333 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d172.s7.e5" } ] }, { "id": "8208", "type": "Species", "text": [ "zebrafish" ], "offsets": [ [ 1405, 1414 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d172.s7.e6" } ] }, { "id": "8209", "type": "Diseases", "text": [ "spinal cord injury" ], "offsets": [ [ 1572, 1590 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d172.s8.e0" } ] }, { "id": "8210", "type": "Specific_miRNAs", "text": [ "miR-133b" ], "offsets": [ [ 1432, 1440 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d172.s8.e1" } ] }, { "id": "8211", "type": "Relation_Trigger", "text": [ "inhibit" ], "offsets": [ [ 1468, 1475 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d172.s8.e2" } ] }, { "id": "8212", "type": "Relation_Trigger", "text": [ "suppress" ], "offsets": [ [ 1444, 1452 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d172.s8.e3" } ] }, { "id": "8213", "type": "Species", "text": [ "zebrafish" ], "offsets": [ [ 1526, 1535 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d172.s8.e4" } ] } ]

[]

[]

[ { "id": "8214", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d172.s0.e2", "arg2_id": "miRNA-corp.d172.s0.e0", "normalized": [] }, { "id": "8215", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d172.s0.e1", "arg2_id": "miRNA-corp.d172.s0.e0", "normalized": [] }, { "id": "8216", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d172.s5.e2", "arg2_id": "miRNA-corp.d172.s5.e0", "normalized": [] }, { "id": "8217", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d172.s6.e2", "arg2_id": "miRNA-corp.d172.s6.e0", "normalized": [] }, { "id": "8218", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d172.s7.e3", "arg2_id": "miRNA-corp.d172.s7.e0", "normalized": [] }, { "id": "8219", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d172.s7.e3", "arg2_id": "miRNA-corp.d172.s7.e1", "normalized": [] }, { "id": "8220", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d172.s7.e3", "arg2_id": "miRNA-corp.d172.s7.e2", "normalized": [] }, { "id": "8221", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d172.s8.e1", "arg2_id": "miRNA-corp.d172.s8.e0", "normalized": [] } ]

[ { "id": "8223", "type": "title", "text": [ "These findings further support the idea that iron- and aluminum-sulfates induce genotoxicity via a ROS-mediated up-regulation of specific regulatory elements and pathogenic genes that redirect brain cell fate towards progressive dysfunction and apoptotic cell death. " ], "offsets": [ [ 0, 269 ] ] }, { "id": "8224", "type": "abstract", "text": [ "Notably, these same miRNAs are up-regulated in AD brain. " ], "offsets": [ [ 270, 327 ] ] }, { "id": "8225", "type": "abstract", "text": [ "The main finding was that these ROS-generating neurotoxic metal sulfates also up-regulate a specific set of miRNAs that includes miR-9, miR-125b and miR-128. " ], "offsets": [ [ 328, 486 ] ] }, { "id": "8226", "type": "abstract", "text": [ "In this study we have extended our investigations to analyze the expression of micro RNA (miRNA) populations in iron- and aluminum-sulfate treated human neural cells in primary culture. " ], "offsets": [ [ 487, 673 ] ] }, { "id": "8227", "type": "abstract", "text": [ "Notably, iron- and aluminum-sulfate induce genes in cultured human brain cells that exhibit expression patterns similar to those observed to be up-regulated in moderate- to late-stage Alzheimer's disease (AD). " ], "offsets": [ [ 674, 884 ] ] }, { "id": "8228", "type": "abstract", "text": [ "Previous studies have shown that following ROS induction, a family of pathogenic brain genes that promote inflammatory signalling, cellular apoptosis and brain cell death is significantly over-expressed. " ], "offsets": [ [ 885, 1089 ] ] }, { "id": "8229", "type": "abstract", "text": [ "Iron- and aluminum-sulfate together, at nanomolar concentrations, trigger the production of reactive oxygen species (ROS) in cultures of human brain cells. " ], "offsets": [ [ 1090, 1246 ] ] }, { "id": "8230", "type": "abstract", "text": [ "Induction of specific micro RNA (miRNA) species by ROS-generating metal sulfates in primary human brain cells. " ], "offsets": [ [ 1247, 1359 ] ] } ]

[ { "id": "8231", "type": "Relation_Trigger", "text": [ "dysfunction" ], "offsets": [ [ 229, 240 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d173.s0.e0" } ] }, { "id": "8232", "type": "Relation_Trigger", "text": [ "regulatory" ], "offsets": [ [ 138, 148 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d173.s0.e1" } ] }, { "id": "8233", "type": "Relation_Trigger", "text": [ "up-regulation" ], "offsets": [ [ 112, 125 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d173.s0.e2" } ] }, { "id": "8234", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 317, 319 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d173.s1.e0" } ] }, { "id": "8235", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 290, 296 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d173.s1.e1" } ] }, { "id": "8236", "type": "Relation_Trigger", "text": [ "up-regulated" ], "offsets": [ [ 301, 313 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d173.s1.e2" } ] }, { "id": "8237", "type": "Specific_miRNAs", "text": [ "miR-9" ], "offsets": [ [ 457, 462 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d173.s2.e0" } ] }, { "id": "8238", "type": "Specific_miRNAs", "text": [ "miR-125b" ], "offsets": [ [ 464, 472 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d173.s2.e1" } ] }, { "id": "8239", "type": "Specific_miRNAs", "text": [ "miR-128" ], "offsets": [ [ 477, 484 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d173.s2.e2" } ] }, { "id": "8240", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 436, 442 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d173.s2.e3" } ] }, { "id": "8241", "type": "Relation_Trigger", "text": [ "up-regulate" ], "offsets": [ [ 406, 417 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d173.s2.e4" } ] }, { "id": "8242", "type": "Non-Specific_miRNAs", "text": [ "micro RNA" ], "offsets": [ [ 566, 575 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d173.s3.e0" } ] }, { "id": "8243", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 577, 582 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d173.s3.e1" } ] }, { "id": "8244", "type": "Species", "text": [ "human" ], "offsets": [ [ 634, 639 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d173.s3.e2" } ] }, { "id": "8245", "type": "Diseases", "text": [ "Alzheimer's disease" ], "offsets": [ [ 858, 877 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d173.s4.e0" } ] }, { "id": "8246", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 879, 881 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d173.s4.e1" } ] }, { "id": "8247", "type": "Relation_Trigger", "text": [ "up-regulated" ], "offsets": [ [ 818, 830 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d173.s4.e2" } ] }, { "id": "8248", "type": "Species", "text": [ "human" ], "offsets": [ [ 735, 740 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d173.s4.e3" } ] }, { "id": "8249", "type": "Relation_Trigger", "text": [ "over-expressed" ], "offsets": [ [ 1073, 1087 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d173.s5.e0" } ] }, { "id": "8250", "type": "Species", "text": [ "human" ], "offsets": [ [ 1227, 1232 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d173.s6.e0" } ] }, { "id": "8251", "type": "Non-Specific_miRNAs", "text": [ "micro RNA" ], "offsets": [ [ 1269, 1278 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d173.s7.e0" } ] }, { "id": "8252", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1280, 1285 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d173.s7.e1" } ] }, { "id": "8253", "type": "Species", "text": [ "human" ], "offsets": [ [ 1339, 1344 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d173.s7.e2" } ] } ]

[]

[]

[ { "id": "8254", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d173.s1.e1", "arg2_id": "miRNA-corp.d173.s1.e0", "normalized": [] } ]

[ { "id": "8256", "type": "title", "text": [ "As a genetically complex disease, dysregulation of miRNA expression might be a feature of autism spectrum disorders (ASDs). " ], "offsets": [ [ 0, 124 ] ] }, { "id": "8257", "type": "abstract", "text": [ "Using multiplex quantitative polymerase chain reaction (PCR), we compared the expression of 466 human miRNAs from postmortem cerebellar cortex tissue of individuals with ASD (n = 13) and a control set of non-autistic cerebellar samples (n = 13). " ], "offsets": [ [ 125, 371 ] ] }, { "id": "8258", "type": "abstract", "text": [ "microRNAs (miRNAs) are approximately 21 nt transcripts capable of regulating the expression of many mRNAs and are abundant in the brain. " ], "offsets": [ [ 372, 509 ] ] }, { "id": "8259", "type": "abstract", "text": [ "miRNAs have a role in several complex diseases including cancer as well as some neurological diseases such as Tourette's syndrome and Fragile x syndrome. " ], "offsets": [ [ 510, 664 ] ] }, { "id": "8260", "type": "abstract", "text": [ "To validate the finding, we reversed the analysis and compared each non-autism control to a single mean value for each miRNA across all autism cases. " ], "offsets": [ [ 665, 815 ] ] }, { "id": "8261", "type": "abstract", "text": [ "In this analysis, the number of dysregulated miRNAs fell from 28 to 9 miRNAs. " ], "offsets": [ [ 816, 894 ] ] }, { "id": "8262", "type": "abstract", "text": [ "While most miRNAs levels showed little variation across all samples suggesting that autism does not induce global dysfunction of miRNA expression, some miRNAs among the autistic samples were expressed at significantly different levels compared to the mean control value. " ], "offsets": [ [ 895, 1166 ] ] }, { "id": "8263", "type": "abstract", "text": [ "Twenty-eight miRNAs were expressed at significantly different levels compared to the non-autism control set in at least one of the autism samples. " ], "offsets": [ [ 1167, 1314 ] ] }, { "id": "8264", "type": "abstract", "text": [ "Among the predicted targets of dysregulated miRNAs are genes that are known genetic causes of autism such Neurexin and SHANK3. " ], "offsets": [ [ 1315, 1442 ] ] }, { "id": "8265", "type": "abstract", "text": [ "Heterogeneous dysregulation of microRNAs across the autism spectrum. " ], "offsets": [ [ 1443, 1513 ] ] }, { "id": "8266", "type": "abstract", "text": [ "This study finds that altered miRNA expression levels are observed in postmortem cerebellar cortex from autism patients, a finding which suggests that dysregulation of miRNAs may contribute to autism spectrum phenotype. " ], "offsets": [ [ 1514, 1736 ] ] } ]

[ { "id": "8267", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 51, 56 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d174.s0.e0" } ] }, { "id": "8268", "type": "Diseases", "text": [ "autism spectrum disorders" ], "offsets": [ [ 90, 115 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d174.s0.e1" } ] }, { "id": "8269", "type": "Diseases", "text": [ "ASDs" ], "offsets": [ [ 117, 121 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d174.s0.e2" } ] }, { "id": "8270", "type": "Relation_Trigger", "text": [ "dysregulation of miRNA expression" ], "offsets": [ [ 34, 67 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d174.s0.e3" } ] }, { "id": "8271", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 227, 233 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d174.s1.e0" } ] }, { "id": "8272", "type": "Diseases", "text": [ "ASD" ], "offsets": [ [ 295, 298 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d174.s1.e1" } ] }, { "id": "8273", "type": "Species", "text": [ "human" ], "offsets": [ [ 221, 226 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d174.s1.e2" } ] }, { "id": "8274", "type": "Non-Specific_miRNAs", "text": [ "microRNAs" ], "offsets": [ [ 372, 381 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d174.s2.e0" } ] }, { "id": "8275", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 383, 389 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d174.s2.e1" } ] }, { "id": "8276", "type": "Relation_Trigger", "text": [ "regulating the expression" ], "offsets": [ [ 438, 463 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d174.s2.e2" } ] }, { "id": "8277", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 510, 516 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d174.s3.e0" } ] }, { "id": "8278", "type": "Diseases", "text": [ "Tourette's syndrome" ], "offsets": [ [ 620, 639 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d174.s3.e1" } ] }, { "id": "8279", "type": "Diseases", "text": [ "Fragile x syndrome" ], "offsets": [ [ 644, 662 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d174.s3.e2" } ] }, { "id": "8280", "type": "Diseases", "text": [ "cancer" ], "offsets": [ [ 567, 573 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d174.s3.e3" } ] }, { "id": "8281", "type": "Diseases", "text": [ "neurological diseases" ], "offsets": [ [ 590, 611 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d174.s3.e4" } ] }, { "id": "8282", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 784, 789 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d174.s4.e0" } ] }, { "id": "8283", "type": "Diseases", "text": [ "autism" ], "offsets": [ [ 801, 807 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d174.s4.e1" } ] }, { "id": "8284", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 886, 892 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d174.s5.e0" } ] }, { "id": "8285", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 861, 867 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d174.s5.e1" } ] }, { "id": "8286", "type": "Relation_Trigger", "text": [ "dysregulated" ], "offsets": [ [ 848, 860 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d174.s5.e2" } ] }, { "id": "8287", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1024, 1029 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d174.s6.e0" } ] }, { "id": "8288", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1047, 1053 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d174.s6.e1" } ] }, { "id": "8289", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 906, 912 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d174.s6.e2" } ] }, { "id": "8290", "type": "Diseases", "text": [ "autism" ], "offsets": [ [ 979, 985 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d174.s6.e3" } ] }, { "id": "8291", "type": "Relation_Trigger", "text": [ "levels showed little variation" ], "offsets": [ [ 913, 943 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d174.s6.e4" } ] }, { "id": "8292", "type": "Relation_Trigger", "text": [ "dysfunction of miRNA expression" ], "offsets": [ [ 1009, 1040 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d174.s6.e5" } ] }, { "id": "8293", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1180, 1186 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d174.s7.e0" } ] }, { "id": "8294", "type": "Diseases", "text": [ "autism" ], "offsets": [ [ 1298, 1304 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d174.s7.e1" } ] }, { "id": "8295", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1359, 1365 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d174.s8.e0" } ] }, { "id": "8296", "type": "Genes/Proteins", "text": [ "SHANK3" ], "offsets": [ [ 1434, 1440 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d174.s8.e1" } ] }, { "id": "8297", "type": "Relation_Trigger", "text": [ "dysregulated" ], "offsets": [ [ 1346, 1358 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d174.s8.e2" } ] }, { "id": "8298", "type": "Relation_Trigger", "text": [ "predicted targets" ], "offsets": [ [ 1325, 1342 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d174.s8.e3" } ] }, { "id": "8299", "type": "Diseases", "text": [ "autism" ], "offsets": [ [ 1409, 1415 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d174.s8.e4" } ] }, { "id": "8300", "type": "Non-Specific_miRNAs", "text": [ "microRNAs" ], "offsets": [ [ 1474, 1483 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d174.s9.e0" } ] }, { "id": "8301", "type": "Diseases", "text": [ "autism" ], "offsets": [ [ 1495, 1501 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d174.s9.e1" } ] }, { "id": "8302", "type": "Relation_Trigger", "text": [ "dysregulation" ], "offsets": [ [ 1457, 1470 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d174.s9.e2" } ] }, { "id": "8303", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1544, 1549 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d174.s10.e0" } ] }, { "id": "8304", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1682, 1688 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d174.s10.e1" } ] }, { "id": "8305", "type": "Diseases", "text": [ "autism" ], "offsets": [ [ 1618, 1624 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d174.s10.e2" } ] }, { "id": "8306", "type": "Diseases", "text": [ "autism" ], "offsets": [ [ 1707, 1713 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d174.s10.e3" } ] }, { "id": "8307", "type": "Relation_Trigger", "text": [ "dysregulation" ], "offsets": [ [ 1665, 1678 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d174.s10.e4" } ] }, { "id": "8308", "type": "Relation_Trigger", "text": [ "altered miRNA expression levels" ], "offsets": [ [ 1536, 1567 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d174.s10.e5" } ] }, { "id": "8309", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1625, 1633 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d174.s10.e6" } ] } ]

[]

[]

[ { "id": "8310", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d174.s0.e0", "arg2_id": "miRNA-corp.d174.s0.e1", "normalized": [] }, { "id": "8311", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d174.s0.e0", "arg2_id": "miRNA-corp.d174.s0.e2", "normalized": [] }, { "id": "8312", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d174.s1.e0", "arg2_id": "miRNA-corp.d174.s1.e1", "normalized": [] }, { "id": "8313", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d174.s3.e0", "arg2_id": "miRNA-corp.d174.s3.e1", "normalized": [] }, { "id": "8314", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d174.s3.e0", "arg2_id": "miRNA-corp.d174.s3.e2", "normalized": [] }, { "id": "8315", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d174.s3.e0", "arg2_id": "miRNA-corp.d174.s3.e3", "normalized": [] }, { "id": "8316", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d174.s3.e0", "arg2_id": "miRNA-corp.d174.s3.e4", "normalized": [] }, { "id": "8317", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d174.s4.e0", "arg2_id": "miRNA-corp.d174.s4.e1", "normalized": [] }, { "id": "8318", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d174.s6.e2", "arg2_id": "miRNA-corp.d174.s6.e3", "normalized": [] }, { "id": "8319", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d174.s6.e0", "arg2_id": "miRNA-corp.d174.s6.e3", "normalized": [] }, { "id": "8320", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d174.s6.e1", "arg2_id": "miRNA-corp.d174.s6.e3", "normalized": [] }, { "id": "8321", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d174.s7.e0", "arg2_id": "miRNA-corp.d174.s7.e1", "normalized": [] }, { "id": "8322", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d174.s8.e0", "arg2_id": "miRNA-corp.d174.s8.e1", "normalized": [] }, { "id": "8323", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d174.s8.e0", "arg2_id": "miRNA-corp.d174.s8.e4", "normalized": [] }, { "id": "8324", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d174.s9.e0", "arg2_id": "miRNA-corp.d174.s9.e1", "normalized": [] }, { "id": "8325", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d174.s10.e0", "arg2_id": "miRNA-corp.d174.s10.e2", "normalized": [] }, { "id": "8326", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d174.s10.e0", "arg2_id": "miRNA-corp.d174.s10.e3", "normalized": [] }, { "id": "8327", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d174.s10.e1", "arg2_id": "miRNA-corp.d174.s10.e2", "normalized": [] }, { "id": "8328", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d174.s10.e1", "arg2_id": "miRNA-corp.d174.s10.e3", "normalized": [] } ]

[ { "id": "8330", "type": "title", "text": [ "A tight correlation between these miRNAs and APP was found during brain development and in differentiating neurons. " ], "offsets": [ [ 0, 116 ] ] }, { "id": "8331", "type": "abstract", "text": [ "We thus identify miRNAs as novel endogenous regulators of APP expression, suggesting that variations in miRNA expression could contribute to changes in APP expression in the brain during development and disease. " ], "offsets": [ [ 117, 329 ] ] }, { "id": "8332", "type": "abstract", "text": [ "This possibility is further corroborated by the observation that a statistically significant decrease in miR-106b expression was found in sporadic AD patients. " ], "offsets": [ [ 330, 492 ] ] }, { "id": "8333", "type": "abstract", "text": [ "MicroRNA regulation of Alzheimer's Amyloid precursor protein expression. " ], "offsets": [ [ 493, 567 ] ] }, { "id": "8334", "type": "abstract", "text": [ "Gene dosage effects of Amyloid precursor protein (APP) can cause familial AD. Recent evidence suggest that microRNA (miRNA) pathways, implicated in gene transcriptional control, could be involved in the development of sporadic Alzheimer's disease (AD). " ], "offsets": [ [ 568, 821 ] ] }, { "id": "8335", "type": "abstract", "text": [ "We therefore investigated whether miRNAs could participate in the regulation of APP gene expression. " ], "offsets": [ [ 822, 923 ] ] }, { "id": "8336", "type": "abstract", "text": [ "We show that miRNAs belonging to the miR-20a family (that is, miR-20a, miR-17-5p and miR-106b) could regulate APP expression in vitro and at the endogenous level in neuronal cell lines. " ], "offsets": [ [ 924, 1110 ] ] } ]

[ { "id": "8337", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 34, 40 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d175.s0.e0" } ] }, { "id": "8338", "type": "Genes/Proteins", "text": [ "APP" ], "offsets": [ [ 45, 48 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d175.s0.e1" } ] }, { "id": "8339", "type": "Relation_Trigger", "text": [ "correlation" ], "offsets": [ [ 8, 19 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d175.s0.e2" } ] }, { "id": "8340", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 134, 140 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d175.s1.e0" } ] }, { "id": "8341", "type": "Genes/Proteins", "text": [ "APP" ], "offsets": [ [ 175, 178 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d175.s1.e1" } ] }, { "id": "8342", "type": "Genes/Proteins", "text": [ "APP" ], "offsets": [ [ 269, 272 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d175.s1.e2" } ] }, { "id": "8343", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 221, 226 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d175.s1.e3" } ] }, { "id": "8344", "type": "Relation_Trigger", "text": [ "regulators of APP expression" ], "offsets": [ [ 161, 189 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d175.s1.e4" } ] }, { "id": "8345", "type": "Relation_Trigger", "text": [ "variations in miRNA expression" ], "offsets": [ [ 207, 237 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d175.s1.e5" } ] }, { "id": "8346", "type": "Relation_Trigger", "text": [ "changes in APP expression" ], "offsets": [ [ 258, 283 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d175.s1.e6" } ] }, { "id": "8347", "type": "Specific_miRNAs", "text": [ "miR-106b" ], "offsets": [ [ 435, 443 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d175.s2.e0" } ] }, { "id": "8348", "type": "Diseases", "text": [ "sporadic AD" ], "offsets": [ [ 468, 479 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d175.s2.e1" } ] }, { "id": "8349", "type": "Relation_Trigger", "text": [ "significant decrease in miR-106b expression" ], "offsets": [ [ 411, 454 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d175.s2.e2" } ] }, { "id": "8350", "type": "Species", "text": [ "patients" ], "offsets": [ [ 480, 488 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d175.s2.e3" } ] }, { "id": "8351", "type": "Genes/Proteins", "text": [ "Amyloid precursor protein" ], "offsets": [ [ 528, 553 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d175.s3.e0" } ] }, { "id": "8352", "type": "Diseases", "text": [ "Alzheimer's" ], "offsets": [ [ 516, 527 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d175.s3.e1" } ] }, { "id": "8353", "type": "Non-Specific_miRNAs", "text": [ "MicroRNA" ], "offsets": [ [ 493, 501 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d175.s3.e2" } ] }, { "id": "8354", "type": "Relation_Trigger", "text": [ "regulation of Alzheimer's Amyloid precursor protein expression" ], "offsets": [ [ 502, 564 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d175.s3.e3" } ] }, { "id": "8355", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 685, 690 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d175.s4.e0" } ] }, { "id": "8356", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 642, 644 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d175.s4.e1" } ] }, { "id": "8357", "type": "Genes/Proteins", "text": [ "Amyloid precursor protein" ], "offsets": [ [ 591, 616 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d175.s4.e2" } ] }, { "id": "8358", "type": "Genes/Proteins", "text": [ "APP" ], "offsets": [ [ 618, 621 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d175.s4.e3" } ] }, { "id": "8359", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 816, 818 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d175.s4.e4" } ] }, { "id": "8360", "type": "Non-Specific_miRNAs", "text": [ "microRNA" ], "offsets": [ [ 675, 683 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d175.s4.e5" } ] }, { "id": "8361", "type": "Diseases", "text": [ "sporadic Alzheimer's disease" ], "offsets": [ [ 786, 814 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d175.s4.e6" } ] }, { "id": "8362", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 856, 862 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d175.s5.e0" } ] }, { "id": "8363", "type": "Genes/Proteins", "text": [ "APP" ], "offsets": [ [ 902, 905 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d175.s5.e1" } ] }, { "id": "8364", "type": "Relation_Trigger", "text": [ "regulation of APP gene expression" ], "offsets": [ [ 888, 921 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d175.s5.e2" } ] }, { "id": "8365", "type": "Specific_miRNAs", "text": [ "miR-20a" ], "offsets": [ [ 986, 993 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d175.s6.e0" } ] }, { "id": "8366", "type": "Specific_miRNAs", "text": [ "miR-17-5p" ], "offsets": [ [ 995, 1004 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d175.s6.e1" } ] }, { "id": "8367", "type": "Specific_miRNAs", "text": [ "miR-106b" ], "offsets": [ [ 1009, 1017 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d175.s6.e2" } ] }, { "id": "8368", "type": "Genes/Proteins", "text": [ "APP" ], "offsets": [ [ 1034, 1037 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d175.s6.e3" } ] }, { "id": "8369", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 937, 943 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d175.s6.e4" } ] }, { "id": "8370", "type": "Relation_Trigger", "text": [ "regulate APP expression" ], "offsets": [ [ 1025, 1048 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d175.s6.e5" } ] }, { "id": "8371", "type": "Specific_miRNAs", "text": [ "miR-20a" ], "offsets": [ [ 961, 968 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d175.s6.e6" } ] } ]

[]

[]

[ { "id": "8372", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d175.s0.e0", "arg2_id": "miRNA-corp.d175.s0.e1", "normalized": [] }, { "id": "8373", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d175.s1.e3", "arg2_id": "miRNA-corp.d175.s1.e1", "normalized": [] }, { "id": "8374", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d175.s1.e3", "arg2_id": "miRNA-corp.d175.s1.e2", "normalized": [] }, { "id": "8375", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d175.s1.e0", "arg2_id": "miRNA-corp.d175.s1.e1", "normalized": [] }, { "id": "8376", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d175.s1.e0", "arg2_id": "miRNA-corp.d175.s1.e2", "normalized": [] }, { "id": "8377", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d175.s2.e0", "arg2_id": "miRNA-corp.d175.s2.e1", "normalized": [] }, { "id": "8378", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d175.s3.e2", "arg2_id": "miRNA-corp.d175.s3.e1", "normalized": [] }, { "id": "8379", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d175.s3.e2", "arg2_id": "miRNA-corp.d175.s3.e0", "normalized": [] }, { "id": "8380", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d175.s4.e0", "arg2_id": "miRNA-corp.d175.s4.e6", "normalized": [] }, { "id": "8381", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d175.s4.e0", "arg2_id": "miRNA-corp.d175.s4.e1", "normalized": [] }, { "id": "8382", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d175.s4.e0", "arg2_id": "miRNA-corp.d175.s4.e2", "normalized": [] }, { "id": "8383", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d175.s4.e0", "arg2_id": "miRNA-corp.d175.s4.e3", "normalized": [] }, { "id": "8384", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d175.s4.e0", "arg2_id": "miRNA-corp.d175.s4.e4", "normalized": [] }, { "id": "8385", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d175.s4.e5", "arg2_id": "miRNA-corp.d175.s4.e6", "normalized": [] }, { "id": "8386", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d175.s4.e5", "arg2_id": "miRNA-corp.d175.s4.e1", "normalized": [] }, { "id": "8387", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d175.s4.e5", "arg2_id": "miRNA-corp.d175.s4.e2", "normalized": [] }, { "id": "8388", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d175.s4.e5", "arg2_id": "miRNA-corp.d175.s4.e3", "normalized": [] }, { "id": "8389", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d175.s4.e5", "arg2_id": "miRNA-corp.d175.s4.e4", "normalized": [] }, { "id": "8390", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d175.s5.e0", "arg2_id": "miRNA-corp.d175.s5.e1", "normalized": [] }, { "id": "8391", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d175.s6.e0", "arg2_id": "miRNA-corp.d175.s6.e3", "normalized": [] }, { "id": "8392", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d175.s6.e1", "arg2_id": "miRNA-corp.d175.s6.e3", "normalized": [] }, { "id": "8393", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d175.s6.e2", "arg2_id": "miRNA-corp.d175.s6.e3", "normalized": [] }, { "id": "8394", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d175.s6.e4", "arg2_id": "miRNA-corp.d175.s6.e3", "normalized": [] }, { "id": "8395", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d175.s6.e6", "arg2_id": "miRNA-corp.d175.s6.e3", "normalized": [] } ]

[ { "id": "8397", "type": "title", "text": [ "These data suggest a role for HSV-1-induced miRNA-146a in the evasion of HSV-1 from the complement system, and the activation of key elements of the arachidonic acid cascade known to contribute to Alzheimer-type neuropathological change. " ], "offsets": [ [ 0, 240 ] ] }, { "id": "8398", "type": "abstract", "text": [ "A known miRNA-146a target in the brain, complement factor H, was downregulated. " ], "offsets": [ [ 241, 321 ] ] }, { "id": "8399", "type": "abstract", "text": [ "Expression of cytoplasmic phospholipase A2, the inducible prostaglandin synthase cyclooxygenase-2, and the neuroinflammatory cytokine interleukin-1beta were each upregulated. " ], "offsets": [ [ 322, 497 ] ] }, { "id": "8400", "type": "abstract", "text": [ "We report that infection of human primary neural cells with a high phenotypic reactivator HSV-1 (17syn+) induces upregulation of a brain-enriched microRNA (miRNA)-146a that is associated with proinflammatory signaling in stressed brain cells and Alzheimer's disease. " ], "offsets": [ [ 498, 765 ] ] }, { "id": "8401", "type": "abstract", "text": [ "Herpes simplex virus type-1 (HSV-1) infection of human brain cells induces changes in gene expression favorable to the propagation of the infecting agent and detrimental to the function of the host cells. " ], "offsets": [ [ 766, 971 ] ] }, { "id": "8402", "type": "abstract", "text": [ "HSV-1 infection of human brain cells induces miRNA-146a and Alzheimer-type inflammatory signaling. " ], "offsets": [ [ 972, 1072 ] ] } ]

[ { "id": "8403", "type": "Specific_miRNAs", "text": [ "miRNA-146a" ], "offsets": [ [ 44, 54 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d176.s0.e0" } ] }, { "id": "8404", "type": "Relation_Trigger", "text": [ "activation" ], "offsets": [ [ 115, 125 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d176.s0.e1" } ] }, { "id": "8405", "type": "Species", "text": [ "HSV-1" ], "offsets": [ [ 73, 78 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d176.s0.e2" } ] }, { "id": "8406", "type": "Species", "text": [ "HSV-1" ], "offsets": [ [ 30, 35 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d176.s0.e3" } ] }, { "id": "8407", "type": "Diseases", "text": [ "Alzheimer" ], "offsets": [ [ 197, 206 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d176.s0.e4" } ] }, { "id": "8408", "type": "Specific_miRNAs", "text": [ "miRNA-146a" ], "offsets": [ [ 249, 259 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d176.s1.e0" } ] }, { "id": "8409", "type": "Genes/Proteins", "text": [ "complement factor H" ], "offsets": [ [ 281, 300 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d176.s1.e1" } ] }, { "id": "8410", "type": "Relation_Trigger", "text": [ "downregulated" ], "offsets": [ [ 306, 319 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d176.s1.e2" } ] }, { "id": "8411", "type": "Relation_Trigger", "text": [ "target" ], "offsets": [ [ 260, 266 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d176.s1.e3" } ] }, { "id": "8412", "type": "Genes/Proteins", "text": [ "interleukin-1beta" ], "offsets": [ [ 456, 473 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d176.s2.e0" } ] }, { "id": "8413", "type": "Genes/Proteins", "text": [ "prostaglandin synthase cyclooxygenase-2" ], "offsets": [ [ 380, 419 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d176.s2.e1" } ] }, { "id": "8414", "type": "Relation_Trigger", "text": [ "upregulated" ], "offsets": [ [ 484, 495 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d176.s2.e2" } ] }, { "id": "8415", "type": "Specific_miRNAs", "text": [ "microRNA (miRNA)-146a" ], "offsets": [ [ 644, 665 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d176.s3.e0" } ] }, { "id": "8416", "type": "Diseases", "text": [ "Alzheimer's disease" ], "offsets": [ [ 744, 763 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d176.s3.e1" } ] }, { "id": "8417", "type": "Relation_Trigger", "text": [ "upregulation" ], "offsets": [ [ 611, 623 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d176.s3.e2" } ] }, { "id": "8418", "type": "Relation_Trigger", "text": [ "associated" ], "offsets": [ [ 674, 684 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d176.s3.e3" } ] }, { "id": "8419", "type": "Species", "text": [ "HSV-1" ], "offsets": [ [ 588, 593 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d176.s3.e4" } ] }, { "id": "8420", "type": "Diseases", "text": [ "infection" ], "offsets": [ [ 513, 522 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d176.s3.e5" } ] }, { "id": "8421", "type": "Species", "text": [ "human" ], "offsets": [ [ 526, 531 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d176.s3.e6" } ] }, { "id": "8422", "type": "Relation_Trigger", "text": [ "changes in gene expression" ], "offsets": [ [ 841, 867 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d176.s4.e0" } ] }, { "id": "8423", "type": "Species", "text": [ "Herpes simplex virus type-1 (HSV-1" ], "offsets": [ [ 766, 800 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d176.s4.e1" } ] }, { "id": "8424", "type": "Diseases", "text": [ "Herpes simplex virus type-1 (HSV-1) infection" ], "offsets": [ [ 766, 811 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d176.s4.e2" } ] }, { "id": "8425", "type": "Species", "text": [ "human" ], "offsets": [ [ 815, 820 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d176.s4.e3" } ] }, { "id": "8426", "type": "Specific_miRNAs", "text": [ "miRNA-146a" ], "offsets": [ [ 1017, 1027 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d176.s5.e0" } ] }, { "id": "8427", "type": "Species", "text": [ "HSV-1" ], "offsets": [ [ 972, 977 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d176.s5.e1" } ] }, { "id": "8428", "type": "Diseases", "text": [ "HSV-1 infection" ], "offsets": [ [ 972, 987 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d176.s5.e2" } ] }, { "id": "8429", "type": "Diseases", "text": [ "Alzheimer" ], "offsets": [ [ 1032, 1041 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d176.s5.e3" } ] }, { "id": "8430", "type": "Species", "text": [ "human" ], "offsets": [ [ 991, 996 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d176.s5.e4" } ] } ]

[]

[]

[ { "id": "8431", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d176.s0.e0", "arg2_id": "miRNA-corp.d176.s0.e4", "normalized": [] }, { "id": "8432", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d176.s1.e0", "arg2_id": "miRNA-corp.d176.s1.e1", "normalized": [] }, { "id": "8433", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d176.s3.e0", "arg2_id": "miRNA-corp.d176.s3.e5", "normalized": [] }, { "id": "8434", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d176.s3.e0", "arg2_id": "miRNA-corp.d176.s3.e1", "normalized": [] }, { "id": "8435", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d176.s5.e0", "arg2_id": "miRNA-corp.d176.s5.e2", "normalized": [] }, { "id": "8436", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d176.s5.e0", "arg2_id": "miRNA-corp.d176.s5.e3", "normalized": [] } ]

[ { "id": "8438", "type": "title", "text": [ "We concluded that patients with partial recurrent seizures of temporal origin have poor subjective sleep quality that improves significantly after epilepsy surgery. " ], "offsets": [ [ 0, 167 ] ] }, { "id": "8439", "type": "abstract", "text": [ "ESS and PSQI scores were also analyzed by gender, antiepileptic drug class, age, and seizure frequency, with no significant differences. " ], "offsets": [ [ 168, 305 ] ] }, { "id": "8440", "type": "abstract", "text": [ "Two questionnaires were used to assess daytime sleepiness (Epworth Sleepiness Scale [ESS]) and sleep quality (Pittsburgh Sleep Quality Index [PSQI]). " ], "offsets": [ [ 306, 456 ] ] }, { "id": "8441", "type": "abstract", "text": [ "PSQI evaluation revealed higher and statistically significant scores in three components as well as in the global score, when analyzed by predominance of daytime or nocturnal seizures. " ], "offsets": [ [ 457, 642 ] ] }, { "id": "8442", "type": "abstract", "text": [ "Evaluation of sleep quality in patients with refractory seizures who undergo epilepsy surgery. " ], "offsets": [ [ 643, 739 ] ] }, { "id": "8443", "type": "abstract", "text": [ "The aim of the study was to evaluate excessive daytime sleepiness and subjective sleep quality in patients who undergo epilepsy surgery for treatment of refractory partial seizures. " ], "offsets": [ [ 740, 922 ] ] }, { "id": "8444", "type": "abstract", "text": [ "Forty-eight patients were enrolled in this research study. " ], "offsets": [ [ 923, 982 ] ] } ]

[ { "id": "8445", "type": "Diseases", "text": [ "partial recurrent seizures" ], "offsets": [ [ 32, 58 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d177.s0.e0" } ] }, { "id": "8446", "type": "Diseases", "text": [ "epilepsy" ], "offsets": [ [ 147, 155 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d177.s0.e1" } ] }, { "id": "8447", "type": "Species", "text": [ "patients" ], "offsets": [ [ 18, 26 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d177.s0.e2" } ] }, { "id": "8448", "type": "Diseases", "text": [ "seizure" ], "offsets": [ [ 253, 260 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d177.s1.e0" } ] }, { "id": "8449", "type": "Diseases", "text": [ "daytime sleepiness" ], "offsets": [ [ 345, 363 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d177.s3.e0" } ] }, { "id": "8450", "type": "Diseases", "text": [ "nocturnal seizures" ], "offsets": [ [ 622, 640 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d177.s4.e0" } ] }, { "id": "8451", "type": "Diseases", "text": [ "epilepsy" ], "offsets": [ [ 720, 728 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d177.s5.e0" } ] }, { "id": "8452", "type": "Diseases", "text": [ "seizures" ], "offsets": [ [ 699, 707 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d177.s5.e1" } ] }, { "id": "8453", "type": "Species", "text": [ "patients" ], "offsets": [ [ 674, 682 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d177.s5.e2" } ] }, { "id": "8454", "type": "Diseases", "text": [ "excessive daytime sleepiness" ], "offsets": [ [ 777, 805 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d177.s6.e0" } ] }, { "id": "8455", "type": "Diseases", "text": [ "seizures" ], "offsets": [ [ 912, 920 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d177.s6.e1" } ] }, { "id": "8456", "type": "Diseases", "text": [ "epilepsy" ], "offsets": [ [ 859, 867 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d177.s6.e2" } ] }, { "id": "8457", "type": "Species", "text": [ "patients" ], "offsets": [ [ 838, 846 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d177.s6.e3" } ] }, { "id": "8458", "type": "Species", "text": [ "patients" ], "offsets": [ [ 935, 943 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d177.s7.e0" } ] } ]

[]

[]

[]

[ { "id": "8460", "type": "title", "text": [ "Here, we investigated the possibility that IFN-beta may induce or downregulate cellular microRNAs (miRNA) in human neoplasms and thereby use the RNA interference system to show antitumor effects. " ], "offsets": [ [ 0, 196 ] ] }, { "id": "8461", "type": "abstract", "text": [ "Because of its known connection to glioma biology, we focused on miR-21 among seven miRNAs influenced by IFN-beta. " ], "offsets": [ [ 197, 312 ] ] }, { "id": "8462", "type": "abstract", "text": [ "The modulation of microRNAs by type I IFN through the activation of signal transducers and activators of transcription 3 in human glioma. " ], "offsets": [ [ 313, 452 ] ] }, { "id": "8463", "type": "abstract", "text": [ "Type I IFNs are involved in double-stranded RNA responses. " ], "offsets": [ [ 453, 512 ] ] }, { "id": "8464", "type": "abstract", "text": [ "The levels of primary miR-21 gene transcripts, precursor miR-21, and mature miR-21 decreased 6 hours after the addition of IFN-beta, indicating that the reduction in miR-21 levels was due to transcriptional suppression. " ], "offsets": [ [ 513, 733 ] ] }, { "id": "8465", "type": "abstract", "text": [ "We did reporter assays to elucidate the IFN-beta-mediated suppression of miR-21; the addition of signal transducers and activators of transcription 3 (STAT3)-expressing vectors induced the IFN-beta-mediated suppression of miR-21, whereas STAT3-inhibiting agents inhibited the miR-21 suppression. " ], "offsets": [ [ 734, 1030 ] ] }, { "id": "8466", "type": "abstract", "text": [ "We analyzed the effect of IFN-beta treatment on miR-21 expression in glioma cells and intracranial glioma xenografts. " ], "offsets": [ [ 1031, 1149 ] ] }, { "id": "8467", "type": "abstract", "text": [ "IFN-beta treatment reduced miR-21 expression in glioma cells markedly, and IFN-beta administration suppressed the growth of glioma-initiating cell-derived intracranial tumors. " ], "offsets": [ [ 1150, 1326 ] ] }, { "id": "8468", "type": "abstract", "text": [ "Thus, the results of our study show that the downregulation of miR-21 contributes to the antitumor effects of IFN-beta and that miR-21 expression is negatively regulated by STAT3 activation. " ], "offsets": [ [ 1327, 1518 ] ] }, { "id": "8469", "type": "abstract", "text": [ "These results highlight the importance of understanding the transcriptional regulation of the miRNAs involved in oncogenesis. " ], "offsets": [ [ 1519, 1647 ] ] } ]

[ { "id": "8470", "type": "Genes/Proteins", "text": [ "IFN-beta" ], "offsets": [ [ 43, 51 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s0.e0" } ] }, { "id": "8471", "type": "Non-Specific_miRNAs", "text": [ "microRNAs" ], "offsets": [ [ 88, 97 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s0.e1" } ] }, { "id": "8472", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 99, 104 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s0.e2" } ] }, { "id": "8473", "type": "Relation_Trigger", "text": [ "downregulate" ], "offsets": [ [ 66, 78 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s0.e3" } ] }, { "id": "8474", "type": "Diseases", "text": [ "neoplasms" ], "offsets": [ [ 115, 124 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s0.e4" } ] }, { "id": "8475", "type": "Species", "text": [ "human" ], "offsets": [ [ 109, 114 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s0.e5" } ] }, { "id": "8476", "type": "Genes/Proteins", "text": [ "IFN-beta" ], "offsets": [ [ 302, 310 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s1.e0" } ] }, { "id": "8477", "type": "Diseases", "text": [ "glioma" ], "offsets": [ [ 232, 238 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s1.e1" } ] }, { "id": "8478", "type": "Specific_miRNAs", "text": [ "miR-21" ], "offsets": [ [ 262, 268 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s1.e2" } ] }, { "id": "8479", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 281, 287 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s1.e3" } ] }, { "id": "8480", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 281, 287 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s1.e4" } ] }, { "id": "8481", "type": "Diseases", "text": [ "glioma" ], "offsets": [ [ 443, 449 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s2.e0" } ] }, { "id": "8482", "type": "Genes/Proteins", "text": [ "signal transducers and activators of transcription 3" ], "offsets": [ [ 381, 433 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s2.e1" } ] }, { "id": "8483", "type": "Non-Specific_miRNAs", "text": [ "microRNAs" ], "offsets": [ [ 331, 340 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s2.e2" } ] }, { "id": "8484", "type": "Relation_Trigger", "text": [ "modulation" ], "offsets": [ [ 317, 327 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s2.e3" } ] }, { "id": "8485", "type": "Relation_Trigger", "text": [ "activation" ], "offsets": [ [ 367, 377 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s2.e4" } ] }, { "id": "8486", "type": "Genes/Proteins", "text": [ "type I IFN" ], "offsets": [ [ 344, 354 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s2.e5" } ] }, { "id": "8487", "type": "Species", "text": [ "human" ], "offsets": [ [ 437, 442 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s2.e6" } ] }, { "id": "8488", "type": "Genes/Proteins", "text": [ "Type I IFNs" ], "offsets": [ [ 453, 464 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s3.e0" } ] }, { "id": "8489", "type": "Specific_miRNAs", "text": [ "miR-21" ], "offsets": [ [ 535, 541 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s4.e0" } ] }, { "id": "8490", "type": "Specific_miRNAs", "text": [ "miR-21" ], "offsets": [ [ 570, 576 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s4.e1" } ] }, { "id": "8491", "type": "Specific_miRNAs", "text": [ "miR-21" ], "offsets": [ [ 679, 685 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s4.e2" } ] }, { "id": "8492", "type": "Specific_miRNAs", "text": [ "miR-21" ], "offsets": [ [ 589, 595 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s4.e3" } ] }, { "id": "8493", "type": "Genes/Proteins", "text": [ "IFN-beta" ], "offsets": [ [ 636, 644 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s4.e4" } ] }, { "id": "8494", "type": "Relation_Trigger", "text": [ "levels of primary miR-21 gene transcripts, precursor miR-21, and mature miR-21 decreased" ], "offsets": [ [ 517, 605 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s4.e5" } ] }, { "id": "8495", "type": "Relation_Trigger", "text": [ "reduction in miR-21 levels" ], "offsets": [ [ 666, 692 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s4.e6" } ] }, { "id": "8496", "type": "Relation_Trigger", "text": [ "suppression" ], "offsets": [ [ 720, 731 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s4.e7" } ] }, { "id": "8497", "type": "Specific_miRNAs", "text": [ "miR-21" ], "offsets": [ [ 1010, 1016 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s5.e0" } ] }, { "id": "8498", "type": "Specific_miRNAs", "text": [ "miR-21" ], "offsets": [ [ 956, 962 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s5.e1" } ] }, { "id": "8499", "type": "Specific_miRNAs", "text": [ "miR-21" ], "offsets": [ [ 807, 813 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s5.e2" } ] }, { "id": "8500", "type": "Genes/Proteins", "text": [ "IFN-beta" ], "offsets": [ [ 923, 931 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s5.e3" } ] }, { "id": "8501", "type": "Relation_Trigger", "text": [ "suppression" ], "offsets": [ [ 792, 803 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s5.e4" } ] }, { "id": "8502", "type": "Relation_Trigger", "text": [ "suppression" ], "offsets": [ [ 941, 952 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s5.e5" } ] }, { "id": "8503", "type": "Relation_Trigger", "text": [ "inhibited" ], "offsets": [ [ 996, 1005 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s5.e6" } ] }, { "id": "8504", "type": "Genes/Proteins", "text": [ "IFN-beta" ], "offsets": [ [ 774, 782 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s5.e7" } ] }, { "id": "8505", "type": "Relation_Trigger", "text": [ "activators" ], "offsets": [ [ 854, 864 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s5.e8" } ] }, { "id": "8506", "type": "Genes/Proteins", "text": [ "STAT3" ], "offsets": [ [ 885, 890 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s5.e9" } ] }, { "id": "8507", "type": "Genes/Proteins", "text": [ "signal transducers and activators of transcription 3" ], "offsets": [ [ 831, 883 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s5.e10" } ] }, { "id": "8508", "type": "Relation_Trigger", "text": [ "suppression" ], "offsets": [ [ 1017, 1028 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s5.e11" } ] }, { "id": "8509", "type": "Specific_miRNAs", "text": [ "miR-21" ], "offsets": [ [ 1079, 1085 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s6.e0" } ] }, { "id": "8510", "type": "Diseases", "text": [ "glioma" ], "offsets": [ [ 1100, 1106 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s6.e1" } ] }, { "id": "8511", "type": "Genes/Proteins", "text": [ "IFN-beta" ], "offsets": [ [ 1057, 1065 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s6.e2" } ] }, { "id": "8512", "type": "Diseases", "text": [ "intracranial glioma" ], "offsets": [ [ 1117, 1136 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s6.e3" } ] }, { "id": "8513", "type": "Specific_miRNAs", "text": [ "miR-21" ], "offsets": [ [ 1177, 1183 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s7.e0" } ] }, { "id": "8514", "type": "Genes/Proteins", "text": [ "IFN-beta" ], "offsets": [ [ 1150, 1158 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s7.e1" } ] }, { "id": "8515", "type": "Genes/Proteins", "text": [ "IFN-beta" ], "offsets": [ [ 1225, 1233 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s7.e2" } ] }, { "id": "8516", "type": "Diseases", "text": [ "glioma" ], "offsets": [ [ 1198, 1204 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s7.e3" } ] }, { "id": "8517", "type": "Diseases", "text": [ "glioma" ], "offsets": [ [ 1274, 1280 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s7.e4" } ] }, { "id": "8518", "type": "Relation_Trigger", "text": [ "suppressed" ], "offsets": [ [ 1249, 1259 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s7.e5" } ] }, { "id": "8519", "type": "Relation_Trigger", "text": [ "reduced miR-21 expression" ], "offsets": [ [ 1169, 1194 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s7.e6" } ] }, { "id": "8520", "type": "Diseases", "text": [ "intracranial tumors" ], "offsets": [ [ 1305, 1324 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s7.e7" } ] }, { "id": "8521", "type": "Specific_miRNAs", "text": [ "miR-21" ], "offsets": [ [ 1390, 1396 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s8.e0" } ] }, { "id": "8522", "type": "Specific_miRNAs", "text": [ "miR-21" ], "offsets": [ [ 1455, 1461 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s8.e1" } ] }, { "id": "8523", "type": "Genes/Proteins", "text": [ "IFN-beta" ], "offsets": [ [ 1437, 1445 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s8.e2" } ] }, { "id": "8524", "type": "Genes/Proteins", "text": [ "STAT3" ], "offsets": [ [ 1500, 1505 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s8.e3" } ] }, { "id": "8525", "type": "Relation_Trigger", "text": [ "downregulation" ], "offsets": [ [ 1372, 1386 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s8.e4" } ] }, { "id": "8526", "type": "Relation_Trigger", "text": [ "negatively regulated" ], "offsets": [ [ 1476, 1496 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s8.e5" } ] }, { "id": "8527", "type": "Relation_Trigger", "text": [ "activation" ], "offsets": [ [ 1506, 1516 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s8.e6" } ] }, { "id": "8528", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1613, 1619 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s9.e0" } ] }, { "id": "8529", "type": "Relation_Trigger", "text": [ "transcriptional regulation" ], "offsets": [ [ 1579, 1605 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d178.s9.e1" } ] } ]

[]

[]

[ { "id": "8530", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d178.s0.e1", "arg2_id": "miRNA-corp.d178.s0.e0", "normalized": [] }, { "id": "8531", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d178.s0.e1", "arg2_id": "miRNA-corp.d178.s0.e4", "normalized": [] }, { "id": "8532", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d178.s0.e2", "arg2_id": "miRNA-corp.d178.s0.e0", "normalized": [] }, { "id": "8533", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d178.s0.e2", "arg2_id": "miRNA-corp.d178.s0.e4", "normalized": [] }, { "id": "8534", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d178.s1.e3", "arg2_id": "miRNA-corp.d178.s1.e0", "normalized": [] }, { "id": "8535", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d178.s1.e3", "arg2_id": "miRNA-corp.d178.s1.e1", "normalized": [] }, { "id": "8536", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d178.s1.e4", "arg2_id": "miRNA-corp.d178.s1.e0", "normalized": [] }, { "id": "8537", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d178.s1.e4", "arg2_id": "miRNA-corp.d178.s1.e1", "normalized": [] }, { "id": "8538", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d178.s1.e2", "arg2_id": "miRNA-corp.d178.s1.e0", "normalized": [] }, { "id": "8539", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d178.s1.e2", "arg2_id": "miRNA-corp.d178.s1.e1", "normalized": [] }, { "id": "8540", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d178.s2.e2", "arg2_id": "miRNA-corp.d178.s2.e0", "normalized": [] }, { "id": "8541", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d178.s2.e2", "arg2_id": "miRNA-corp.d178.s2.e1", "normalized": [] }, { "id": "8542", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d178.s2.e2", "arg2_id": "miRNA-corp.d178.s2.e5", "normalized": [] }, { "id": "8543", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d178.s4.e2", "arg2_id": "miRNA-corp.d178.s4.e4", "normalized": [] }, { "id": "8544", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d178.s4.e3", "arg2_id": "miRNA-corp.d178.s4.e4", "normalized": [] }, { "id": "8545", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d178.s4.e0", "arg2_id": "miRNA-corp.d178.s4.e4", "normalized": [] }, { "id": "8546", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d178.s4.e1", "arg2_id": "miRNA-corp.d178.s4.e4", "normalized": [] }, { "id": "8547", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d178.s5.e0", "arg2_id": "miRNA-corp.d178.s5.e3", "normalized": [] }, { "id": "8548", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d178.s5.e0", "arg2_id": "miRNA-corp.d178.s5.e7", "normalized": [] }, { "id": "8549", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d178.s5.e0", "arg2_id": "miRNA-corp.d178.s5.e9", "normalized": [] }, { "id": "8550", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d178.s5.e0", "arg2_id": "miRNA-corp.d178.s5.e10", "normalized": [] }, { "id": "8551", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d178.s5.e1", "arg2_id": "miRNA-corp.d178.s5.e3", "normalized": [] }, { "id": "8552", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d178.s5.e1", "arg2_id": "miRNA-corp.d178.s5.e7", "normalized": [] }, { "id": "8553", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d178.s5.e1", "arg2_id": "miRNA-corp.d178.s5.e9", "normalized": [] }, { "id": "8554", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d178.s5.e1", "arg2_id": "miRNA-corp.d178.s5.e10", "normalized": [] }, { "id": "8555", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d178.s5.e2", "arg2_id": "miRNA-corp.d178.s5.e3", "normalized": [] }, { "id": "8556", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d178.s5.e2", "arg2_id": "miRNA-corp.d178.s5.e7", "normalized": [] }, { "id": "8557", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d178.s5.e2", "arg2_id": "miRNA-corp.d178.s5.e9", "normalized": [] }, { "id": "8558", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d178.s5.e2", "arg2_id": "miRNA-corp.d178.s5.e10", "normalized": [] }, { "id": "8559", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d178.s6.e0", "arg2_id": "miRNA-corp.d178.s6.e1", "normalized": [] }, { "id": "8560", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d178.s6.e0", "arg2_id": "miRNA-corp.d178.s6.e2", "normalized": [] }, { "id": "8561", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d178.s6.e0", "arg2_id": "miRNA-corp.d178.s6.e3", "normalized": [] }, { "id": "8562", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d178.s7.e0", "arg2_id": "miRNA-corp.d178.s7.e1", "normalized": [] }, { "id": "8563", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d178.s7.e0", "arg2_id": "miRNA-corp.d178.s7.e2", "normalized": [] }, { "id": "8564", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d178.s7.e0", "arg2_id": "miRNA-corp.d178.s7.e3", "normalized": [] }, { "id": "8565", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d178.s7.e0", "arg2_id": "miRNA-corp.d178.s7.e4", "normalized": [] }, { "id": "8566", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d178.s7.e0", "arg2_id": "miRNA-corp.d178.s7.e7", "normalized": [] }, { "id": "8567", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d178.s8.e0", "arg2_id": "miRNA-corp.d178.s8.e2", "normalized": [] }, { "id": "8568", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d178.s8.e0", "arg2_id": "miRNA-corp.d178.s8.e3", "normalized": [] }, { "id": "8569", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d178.s8.e1", "arg2_id": "miRNA-corp.d178.s8.e2", "normalized": [] }, { "id": "8570", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d178.s8.e1", "arg2_id": "miRNA-corp.d178.s8.e3", "normalized": [] } ]

[ { "id": "8572", "type": "title", "text": [ "This study reveals the occurrence of novel mechanisms of HIF regulation, which might contribute to developing novel strategies for therapeutic intervention of HIF-related pathologies, including heart attack, cancer, and stroke. " ], "offsets": [ [ 0, 230 ] ] }, { "id": "8573", "type": "abstract", "text": [ "One remarkable hit was the argonaute 1 (ago1) gene, a central element of the microRNA (miRNA) translational silencing machinery. " ], "offsets": [ [ 231, 360 ] ] }, { "id": "8574", "type": "abstract", "text": [ "Further studies confirmed the physiological role of the miRNA machinery in HIF-dependent transcription. " ], "offsets": [ [ 361, 465 ] ] }, { "id": "8575", "type": "abstract", "text": [ "After 3 rounds of selection, 30 genes emerged as critical HIF regulators in hypoxia, most of which had not been previously associated with HIF biology. " ], "offsets": [ [ 466, 618 ] ] }, { "id": "8576", "type": "abstract", "text": [ "The list of genes includes components of chromatin remodeling complexes, transcription elongation factors, and translational regulators. " ], "offsets": [ [ 619, 756 ] ] }, { "id": "8577", "type": "abstract", "text": [ "Molecular mechanisms that mediate oxygen-dependent HIF regulation operate at the level of the alpha subunit, controlling protein stability, subcellular localization, and transcriptional coactivator recruitment. " ], "offsets": [ [ 757, 968 ] ] }, { "id": "8578", "type": "abstract", "text": [ "Drosophila genome-wide RNAi screen identifies multiple regulators of HIF-dependent transcription in hypoxia. " ], "offsets": [ [ 969, 1079 ] ] } ]

[ { "id": "8579", "type": "Diseases", "text": [ "heart attack" ], "offsets": [ [ 194, 206 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d179.s0.e0" } ] }, { "id": "8580", "type": "Diseases", "text": [ "cancer" ], "offsets": [ [ 208, 214 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d179.s0.e1" } ] }, { "id": "8581", "type": "Diseases", "text": [ "stroke" ], "offsets": [ [ 220, 226 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d179.s0.e2" } ] }, { "id": "8582", "type": "Relation_Trigger", "text": [ "regulation" ], "offsets": [ [ 61, 71 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d179.s0.e3" } ] }, { "id": "8583", "type": "Genes/Proteins", "text": [ "ago1" ], "offsets": [ [ 271, 275 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d179.s1.e0" } ] }, { "id": "8584", "type": "Non-Specific_miRNAs", "text": [ "microRNA" ], "offsets": [ [ 308, 316 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d179.s1.e1" } ] }, { "id": "8585", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 318, 323 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d179.s1.e2" } ] }, { "id": "8586", "type": "Genes/Proteins", "text": [ "argonaute 1" ], "offsets": [ [ 258, 269 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d179.s1.e3" } ] }, { "id": "8587", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 417, 422 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d179.s2.e0" } ] }, { "id": "8588", "type": "Relation_Trigger", "text": [ "regulators" ], "offsets": [ [ 528, 538 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d179.s3.e0" } ] }, { "id": "8589", "type": "Relation_Trigger", "text": [ "associated" ], "offsets": [ [ 589, 599 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d179.s3.e1" } ] }, { "id": "8590", "type": "Diseases", "text": [ "hypoxia" ], "offsets": [ [ 542, 549 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d179.s3.e2" } ] }, { "id": "8591", "type": "Relation_Trigger", "text": [ "translational regulators" ], "offsets": [ [ 730, 754 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d179.s4.e0" } ] }, { "id": "8592", "type": "Relation_Trigger", "text": [ "regulation" ], "offsets": [ [ 812, 822 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d179.s5.e0" } ] }, { "id": "8593", "type": "Relation_Trigger", "text": [ "regulators of HIF-dependent transcription" ], "offsets": [ [ 1024, 1065 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d179.s7.e0" } ] }, { "id": "8594", "type": "Diseases", "text": [ "hypoxia" ], "offsets": [ [ 1069, 1076 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d179.s7.e1" } ] } ]

[]

[]

[ { "id": "8595", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d179.s1.e1", "arg2_id": "miRNA-corp.d179.s1.e0", "normalized": [] }, { "id": "8596", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d179.s1.e1", "arg2_id": "miRNA-corp.d179.s1.e3", "normalized": [] }, { "id": "8597", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d179.s1.e2", "arg2_id": "miRNA-corp.d179.s1.e0", "normalized": [] }, { "id": "8598", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d179.s1.e2", "arg2_id": "miRNA-corp.d179.s1.e3", "normalized": [] } ]

[ { "id": "8600", "type": "title", "text": [ "In a well-characterized Belgian group of 358 AD patients and 462 controls, we examined whether genetic variability in microRNA (miRNA) binding sites of APP and BACE1 or in associated miRNAs influenced risk for AD. Direct sequencing identified six variants in the 3' untranslated region (UTR) of APP and 29 variants in the 3' UTR of BACE1, of which few variants were restricted to patients: in APP; 4 variants in 6 patients ( approximately 2%) and in BACE1; 7 variants in 11 patients ( approximately 3.5%). " ], "offsets": [ [ 0, 506 ] ] }, { "id": "8601", "type": "abstract", "text": [ "Expression levels of the amyloid precursor protein (APP) and beta-site amyloid (Abeta) cleaving enzyme 1 (BACE1) have been implicated in Alzheimer disease (AD) progression. " ], "offsets": [ [ 507, 680 ] ] }, { "id": "8602", "type": "abstract", "text": [ "APP and BACE1 miRNA genetic variability has no major role in risk for Alzheimer disease. " ], "offsets": [ [ 681, 771 ] ] }, { "id": "8603", "type": "abstract", "text": [ "Further genetic screening of the miR-29 cluster encoding the miR-29a/b-1 genes showed 10 variants in close proximity of this cluster. " ], "offsets": [ [ 772, 906 ] ] }, { "id": "8604", "type": "abstract", "text": [ "Association studies using all common variants detected in the 3' UTR of BACE1 and the miR-29 gene cluster did not identify an association with AD risk. " ], "offsets": [ [ 907, 1059 ] ] }, { "id": "8605", "type": "abstract", "text": [ "However, we did observe statistical interaction between rs535860 (BACE1 3' UTR) and rs34772568 (near miR29a; odds ratio [OR](interaction), 0.4; 95% confidence interval [CI], 0.17-0.96; P=0.033). " ], "offsets": [ [ 1060, 1255 ] ] }, { "id": "8606", "type": "abstract", "text": [ "While the exact role of the patient-specific miRNA variants within the 3' UTR region of APP and BACE1 demands further analyses, this study does not support a major contribution of miRNA genetic variability to AD pathogenesis. " ], "offsets": [ [ 1256, 1484 ] ] } ]

[ { "id": "8607", "type": "Genes/Proteins", "text": [ "BACE1" ], "offsets": [ [ 450, 455 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d180.s0.e0" } ] }, { "id": "8608", "type": "Genes/Proteins", "text": [ "BACE1" ], "offsets": [ [ 332, 337 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d180.s0.e1" } ] }, { "id": "8609", "type": "Genes/Proteins", "text": [ "BACE1" ], "offsets": [ [ 160, 165 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d180.s0.e2" } ] }, { "id": "8610", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 45, 47 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d180.s0.e3" } ] }, { "id": "8611", "type": "Genes/Proteins", "text": [ "APP" ], "offsets": [ [ 152, 155 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d180.s0.e4" } ] }, { "id": "8612", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 210, 212 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d180.s0.e5" } ] }, { "id": "8613", "type": "Genes/Proteins", "text": [ "APP" ], "offsets": [ [ 295, 298 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d180.s0.e6" } ] }, { "id": "8614", "type": "Genes/Proteins", "text": [ "APP" ], "offsets": [ [ 393, 396 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d180.s0.e7" } ] }, { "id": "8615", "type": "Non-Specific_miRNAs", "text": [ "microRNA" ], "offsets": [ [ 118, 126 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d180.s0.e8" } ] }, { "id": "8616", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 128, 133 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d180.s0.e9" } ] }, { "id": "8617", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 183, 189 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d180.s0.e10" } ] }, { "id": "8618", "type": "Relation_Trigger", "text": [ "binding sites" ], "offsets": [ [ 135, 148 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d180.s0.e11" } ] }, { "id": "8619", "type": "Relation_Trigger", "text": [ "associated" ], "offsets": [ [ 172, 182 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d180.s0.e12" } ] }, { "id": "8620", "type": "Species", "text": [ "patients" ], "offsets": [ [ 414, 422 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d180.s0.e13" } ] }, { "id": "8621", "type": "Species", "text": [ "patients" ], "offsets": [ [ 474, 482 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d180.s0.e14" } ] }, { "id": "8622", "type": "Species", "text": [ "patients" ], "offsets": [ [ 48, 56 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d180.s0.e15" } ] }, { "id": "8623", "type": "Species", "text": [ "patients" ], "offsets": [ [ 380, 388 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d180.s0.e16" } ] }, { "id": "8624", "type": "Diseases", "text": [ "Alzheimer disease" ], "offsets": [ [ 644, 661 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d180.s1.e0" } ] }, { "id": "8625", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 663, 665 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d180.s1.e1" } ] }, { "id": "8626", "type": "Genes/Proteins", "text": [ "amyloid precursor protein" ], "offsets": [ [ 532, 557 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d180.s1.e2" } ] }, { "id": "8627", "type": "Genes/Proteins", "text": [ "APP" ], "offsets": [ [ 559, 562 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d180.s1.e3" } ] }, { "id": "8628", "type": "Genes/Proteins", "text": [ "Abeta" ], "offsets": [ [ 587, 592 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d180.s1.e4" } ] }, { "id": "8629", "type": "Genes/Proteins", "text": [ "BACE1" ], "offsets": [ [ 613, 618 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d180.s1.e5" } ] }, { "id": "8630", "type": "Genes/Proteins", "text": [ "APP" ], "offsets": [ [ 681, 684 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d180.s2.e0" } ] }, { "id": "8631", "type": "Genes/Proteins", "text": [ "BACE1" ], "offsets": [ [ 689, 694 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d180.s2.e1" } ] }, { "id": "8632", "type": "Diseases", "text": [ "Alzheimer disease" ], "offsets": [ [ 751, 768 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d180.s2.e2" } ] }, { "id": "8633", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 695, 700 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d180.s2.e3" } ] }, { "id": "8634", "type": "Specific_miRNAs", "text": [ "miR-29" ], "offsets": [ [ 805, 811 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d180.s3.e0" } ] }, { "id": "8635", "type": "Specific_miRNAs", "text": [ "miR-29a/b-1" ], "offsets": [ [ 833, 844 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d180.s3.e1" } ] }, { "id": "8636", "type": "Specific_miRNAs", "text": [ "miR-29" ], "offsets": [ [ 993, 999 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d180.s4.e0" } ] }, { "id": "8637", "type": "Genes/Proteins", "text": [ "BACE1" ], "offsets": [ [ 979, 984 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d180.s4.e1" } ] }, { "id": "8638", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 1050, 1052 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d180.s4.e2" } ] }, { "id": "8639", "type": "Relation_Trigger", "text": [ "association" ], "offsets": [ [ 1033, 1044 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d180.s4.e3" } ] }, { "id": "8640", "type": "Relation_Trigger", "text": [ "Association" ], "offsets": [ [ 907, 918 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d180.s4.e4" } ] }, { "id": "8641", "type": "Specific_miRNAs", "text": [ "miR29a" ], "offsets": [ [ 1161, 1167 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d180.s5.e0" } ] }, { "id": "8642", "type": "Genes/Proteins", "text": [ "BACE1" ], "offsets": [ [ 1126, 1131 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d180.s5.e1" } ] }, { "id": "8643", "type": "Genes/Proteins", "text": [ "BACE1" ], "offsets": [ [ 1352, 1357 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d180.s6.e0" } ] }, { "id": "8644", "type": "Genes/Proteins", "text": [ "APP" ], "offsets": [ [ 1344, 1347 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d180.s6.e1" } ] }, { "id": "8645", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 1465, 1467 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d180.s6.e2" } ] }, { "id": "8646", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1301, 1306 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d180.s6.e3" } ] }, { "id": "8647", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1436, 1441 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d180.s6.e4" } ] }, { "id": "8648", "type": "Species", "text": [ "patient" ], "offsets": [ [ 1284, 1291 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d180.s6.e5" } ] } ]

[]

[]

[ { "id": "8649", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d180.s0.e8", "arg2_id": "miRNA-corp.d180.s0.e3", "normalized": [] }, { "id": "8650", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d180.s0.e8", "arg2_id": "miRNA-corp.d180.s0.e4", "normalized": [] }, { "id": "8651", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d180.s0.e8", "arg2_id": "miRNA-corp.d180.s0.e5", "normalized": [] }, { "id": "8652", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d180.s0.e8", "arg2_id": "miRNA-corp.d180.s0.e6", "normalized": [] }, { "id": "8653", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d180.s0.e8", "arg2_id": "miRNA-corp.d180.s0.e7", "normalized": [] }, { "id": "8654", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d180.s0.e8", "arg2_id": "miRNA-corp.d180.s0.e0", "normalized": [] }, { "id": "8655", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d180.s0.e8", "arg2_id": "miRNA-corp.d180.s0.e1", "normalized": [] }, { "id": "8656", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d180.s0.e8", "arg2_id": "miRNA-corp.d180.s0.e2", "normalized": [] }, { "id": "8657", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d180.s0.e9", "arg2_id": "miRNA-corp.d180.s0.e3", "normalized": [] }, { "id": "8658", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d180.s0.e9", "arg2_id": "miRNA-corp.d180.s0.e4", "normalized": [] }, { "id": "8659", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d180.s0.e9", "arg2_id": "miRNA-corp.d180.s0.e5", "normalized": [] }, { "id": "8660", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d180.s0.e9", "arg2_id": "miRNA-corp.d180.s0.e6", "normalized": [] }, { "id": "8661", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d180.s0.e9", "arg2_id": "miRNA-corp.d180.s0.e7", "normalized": [] }, { "id": "8662", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d180.s0.e9", "arg2_id": "miRNA-corp.d180.s0.e0", "normalized": [] }, { "id": "8663", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d180.s0.e9", "arg2_id": "miRNA-corp.d180.s0.e1", "normalized": [] }, { "id": "8664", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d180.s0.e9", "arg2_id": "miRNA-corp.d180.s0.e2", "normalized": [] }, { "id": "8665", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d180.s0.e10", "arg2_id": "miRNA-corp.d180.s0.e3", "normalized": [] }, { "id": "8666", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d180.s0.e10", "arg2_id": "miRNA-corp.d180.s0.e4", "normalized": [] }, { "id": "8667", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d180.s0.e10", "arg2_id": "miRNA-corp.d180.s0.e5", "normalized": [] }, { "id": "8668", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d180.s0.e10", "arg2_id": "miRNA-corp.d180.s0.e6", "normalized": [] }, { "id": "8669", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d180.s0.e10", "arg2_id": "miRNA-corp.d180.s0.e7", "normalized": [] }, { "id": "8670", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d180.s0.e10", "arg2_id": "miRNA-corp.d180.s0.e0", "normalized": [] }, { "id": "8671", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d180.s0.e10", "arg2_id": "miRNA-corp.d180.s0.e1", "normalized": [] }, { "id": "8672", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d180.s0.e10", "arg2_id": "miRNA-corp.d180.s0.e2", "normalized": [] }, { "id": "8673", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d180.s2.e3", "arg2_id": "miRNA-corp.d180.s2.e0", "normalized": [] }, { "id": "8674", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d180.s2.e3", "arg2_id": "miRNA-corp.d180.s2.e1", "normalized": [] }, { "id": "8675", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d180.s2.e3", "arg2_id": "miRNA-corp.d180.s2.e2", "normalized": [] }, { "id": "8676", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d180.s4.e0", "arg2_id": "miRNA-corp.d180.s4.e1", "normalized": [] }, { "id": "8677", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d180.s4.e0", "arg2_id": "miRNA-corp.d180.s4.e2", "normalized": [] }, { "id": "8678", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d180.s5.e0", "arg2_id": "miRNA-corp.d180.s5.e1", "normalized": [] }, { "id": "8679", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d180.s6.e3", "arg2_id": "miRNA-corp.d180.s6.e2", "normalized": [] }, { "id": "8680", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d180.s6.e3", "arg2_id": "miRNA-corp.d180.s6.e0", "normalized": [] }, { "id": "8681", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d180.s6.e3", "arg2_id": "miRNA-corp.d180.s6.e1", "normalized": [] }, { "id": "8682", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d180.s6.e4", "arg2_id": "miRNA-corp.d180.s6.e2", "normalized": [] }, { "id": "8683", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d180.s6.e4", "arg2_id": "miRNA-corp.d180.s6.e0", "normalized": [] }, { "id": "8684", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d180.s6.e4", "arg2_id": "miRNA-corp.d180.s6.e1", "normalized": [] } ]

[ { "id": "8686", "type": "title", "text": [ "Differential regulation of interleukin-1 receptor-associated kinase-1 (IRAK-1) and IRAK-2 by microRNA-146a and NF-kappaB in stressed human astroglial cells and in Alzheimer disease. " ], "offsets": [ [ 0, 183 ] ] }, { "id": "8687", "type": "abstract", "text": [ "Specific microRNAs (miRNAs), small non-coding RNAs that support homeostatic gene expression, are significantly altered in abundance in human neurological disorders. " ], "offsets": [ [ 184, 349 ] ] }, { "id": "8688", "type": "abstract", "text": [ "In monocytes, increased expression of an NF-κB-regulated miRNA-146a down-regulates expression of the interleukin-1 receptor-associated kinase-1 (IRAK-1), an essential component of Toll-like/IL-1 receptor signaling. " ], "offsets": [ [ 350, 565 ] ] }, { "id": "8689", "type": "abstract", "text": [ "Here we extend those observations to the hippocampus and neocortex of Alzheimer disease (AD) brain and to stressed human astroglial (HAG) cells in primary culture. " ], "offsets": [ [ 566, 730 ] ] }, { "id": "8690", "type": "abstract", "text": [ "In 66 control and AD samples we note a significant up-regulation of miRNA-146a coupled to down-regulation of IRAK-1 and a compensatory up-regulation of IRAK-2. " ], "offsets": [ [ 731, 891 ] ] }, { "id": "8691", "type": "abstract", "text": [ "Using miRNA-146a-, IRAK-1-, or IRAK-2 promoter-luciferase reporter constructs, we observe decreases in IRAK-1 and increases in miRNA-146a and IRAK-2 expression in interleukin-1β (IL-1β) and amyloid-β-42 (Aβ42) peptide-stressed HAG cells. " ], "offsets": [ [ 892, 1130 ] ] }, { "id": "8692", "type": "abstract", "text": [ "NF-κB-mediated transcriptional control of human IRAK-2 was localized to between -119 and +12 bp of the immediate IRAK-2 promoter. " ], "offsets": [ [ 1131, 1261 ] ] }, { "id": "8693", "type": "abstract", "text": [ "The NF-κB inhibitors curcumin, pyrrolidine dithiocarbamate or CAY10512 abrogated both IRAK-2 and miRNA-146a expression, whereas IRAK-1 was up-regulated. " ], "offsets": [ [ 1262, 1415 ] ] }, { "id": "8694", "type": "abstract", "text": [ "Incubation of a protected antisense miRNA-146a was found to inhibit miRNA-146a and restore IRAK-1, whereas IRAK-2 remained unaffected. " ], "offsets": [ [ 1416, 1551 ] ] }, { "id": "8695", "type": "abstract", "text": [ "These data suggest a significantly independent regulation of IRAK-1 and IRAK-2 in AD and in IL-1β+Aβ42 peptide-stressed HAG cells and that an inducible, NF-κB-sensitive, miRNA-146a-mediated down-regulation of IRAK-1 coupled to an NF-κB-induced up-regulation of IRAK-2 expression drives an extensively sustained inflammatory response. " ], "offsets": [ [ 1552, 1886 ] ] }, { "id": "8696", "type": "abstract", "text": [ "The combinatorial use of NF-κB inhibitors with miRNA-146a or antisense miRNA-146a may have potential as a bi-pronged therapeutic strategy directed against IRAK-2-driven pathogenic signaling. " ], "offsets": [ [ 1887, 2080 ] ] }, { "id": "8697", "type": "abstract", "text": [ "The interactive signaling of NF-κB and miRNA-146a further illustrate interplay between inducible transcription factors and pro-inflammatory miRNAs that regulate brain IRAK expression. " ], "offsets": [ [ 2081, 2265 ] ] } ]

[ { "id": "8698", "type": "Relation_Trigger", "text": [ "Differential regulation" ], "offsets": [ [ 0, 23 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s0.e0" } ] }, { "id": "8699", "type": "Genes/Proteins", "text": [ "interleukin-1 receptor-associated kinase-1" ], "offsets": [ [ 27, 69 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s0.e1" } ] }, { "id": "8700", "type": "Genes/Proteins", "text": [ "IRAK-1" ], "offsets": [ [ 71, 77 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s0.e2" } ] }, { "id": "8701", "type": "Genes/Proteins", "text": [ "IRAK-2" ], "offsets": [ [ 83, 89 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s0.e3" } ] }, { "id": "8702", "type": "Specific_miRNAs", "text": [ "microRNA-146a" ], "offsets": [ [ 93, 106 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s0.e4" } ] }, { "id": "8703", "type": "Diseases", "text": [ "Alzheimer disease" ], "offsets": [ [ 163, 180 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s0.e5" } ] }, { "id": "8704", "type": "Species", "text": [ "human" ], "offsets": [ [ 133, 138 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s0.e6" } ] }, { "id": "8705", "type": "Non-Specific_miRNAs", "text": [ "microRNAs" ], "offsets": [ [ 193, 202 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s1.e0" } ] }, { "id": "8706", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 204, 210 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s1.e1" } ] }, { "id": "8707", "type": "Diseases", "text": [ "neurological disorders" ], "offsets": [ [ 325, 347 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s1.e2" } ] }, { "id": "8708", "type": "Species", "text": [ "human" ], "offsets": [ [ 319, 324 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s1.e3" } ] }, { "id": "8709", "type": "Relation_Trigger", "text": [ "increased expression" ], "offsets": [ [ 364, 384 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s2.e0" } ] }, { "id": "8710", "type": "Relation_Trigger", "text": [ "down-regulates expression" ], "offsets": [ [ 418, 443 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s2.e1" } ] }, { "id": "8711", "type": "Specific_miRNAs", "text": [ "miRNA-146a" ], "offsets": [ [ 407, 417 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s2.e2" } ] }, { "id": "8712", "type": "Genes/Proteins", "text": [ "interleukin-1 receptor-associated kinase-1" ], "offsets": [ [ 451, 493 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s2.e3" } ] }, { "id": "8713", "type": "Genes/Proteins", "text": [ "IRAK-1" ], "offsets": [ [ 495, 501 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s2.e4" } ] }, { "id": "8714", "type": "Genes/Proteins", "text": [ "IL-1" ], "offsets": [ [ 540, 544 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s2.e5" } ] }, { "id": "8715", "type": "Diseases", "text": [ "Alzheimer disease" ], "offsets": [ [ 636, 653 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s3.e0" } ] }, { "id": "8716", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 655, 657 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s3.e1" } ] }, { "id": "8717", "type": "Species", "text": [ "human" ], "offsets": [ [ 681, 686 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s3.e2" } ] }, { "id": "8718", "type": "Relation_Trigger", "text": [ "up-regulation" ], "offsets": [ [ 782, 795 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s4.e0" } ] }, { "id": "8719", "type": "Relation_Trigger", "text": [ "down-regulation" ], "offsets": [ [ 821, 836 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s4.e1" } ] }, { "id": "8720", "type": "Relation_Trigger", "text": [ "up-regulation" ], "offsets": [ [ 866, 879 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s4.e2" } ] }, { "id": "8721", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 749, 751 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s4.e3" } ] }, { "id": "8722", "type": "Genes/Proteins", "text": [ "IRAK-2" ], "offsets": [ [ 883, 889 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s4.e4" } ] }, { "id": "8723", "type": "Genes/Proteins", "text": [ "IRAK-1" ], "offsets": [ [ 840, 846 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s4.e5" } ] }, { "id": "8724", "type": "Specific_miRNAs", "text": [ "miRNA-146a" ], "offsets": [ [ 799, 809 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s4.e6" } ] }, { "id": "8725", "type": "Genes/Proteins", "text": [ "interleukin-1β" ], "offsets": [ [ 1055, 1069 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s5.e0" } ] }, { "id": "8726", "type": "Genes/Proteins", "text": [ "IL-1β" ], "offsets": [ [ 1071, 1076 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s5.e1" } ] }, { "id": "8727", "type": "Genes/Proteins", "text": [ "amyloid-β-42" ], "offsets": [ [ 1082, 1094 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s5.e2" } ] }, { "id": "8728", "type": "Genes/Proteins", "text": [ "Aβ42" ], "offsets": [ [ 1096, 1100 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s5.e3" } ] }, { "id": "8729", "type": "Genes/Proteins", "text": [ "IRAK-1" ], "offsets": [ [ 911, 917 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s5.e4" } ] }, { "id": "8730", "type": "Genes/Proteins", "text": [ "IRAK-2" ], "offsets": [ [ 923, 929 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s5.e5" } ] }, { "id": "8731", "type": "Genes/Proteins", "text": [ "IRAK-2" ], "offsets": [ [ 1034, 1040 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s5.e6" } ] }, { "id": "8732", "type": "Genes/Proteins", "text": [ "IRAK-1" ], "offsets": [ [ 995, 1001 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s5.e7" } ] }, { "id": "8733", "type": "Specific_miRNAs", "text": [ "miRNA-146a" ], "offsets": [ [ 1019, 1029 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s5.e8" } ] }, { "id": "8734", "type": "Specific_miRNAs", "text": [ "miRNA-146a" ], "offsets": [ [ 898, 908 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s5.e9" } ] }, { "id": "8735", "type": "Relation_Trigger", "text": [ "increases in miRNA-146a and IRAK-2 expression" ], "offsets": [ [ 1006, 1051 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s5.e10" } ] }, { "id": "8736", "type": "Genes/Proteins", "text": [ "IRAK-2" ], "offsets": [ [ 1179, 1185 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s6.e0" } ] }, { "id": "8737", "type": "Genes/Proteins", "text": [ "IRAK-2" ], "offsets": [ [ 1244, 1250 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s6.e1" } ] }, { "id": "8738", "type": "Species", "text": [ "human" ], "offsets": [ [ 1173, 1178 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s6.e2" } ] }, { "id": "8739", "type": "Relation_Trigger", "text": [ "up-regulated" ], "offsets": [ [ 1401, 1413 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s7.e0" } ] }, { "id": "8740", "type": "Genes/Proteins", "text": [ "IRAK-2" ], "offsets": [ [ 1348, 1354 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s7.e1" } ] }, { "id": "8741", "type": "Genes/Proteins", "text": [ "IRAK-1" ], "offsets": [ [ 1390, 1396 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s7.e2" } ] }, { "id": "8742", "type": "Specific_miRNAs", "text": [ "miRNA-146a" ], "offsets": [ [ 1359, 1369 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s7.e3" } ] }, { "id": "8743", "type": "Relation_Trigger", "text": [ "inhibitors" ], "offsets": [ [ 1272, 1282 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s7.e4" } ] }, { "id": "8744", "type": "Relation_Trigger", "text": [ "inhibit" ], "offsets": [ [ 1476, 1483 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s8.e0" } ] }, { "id": "8745", "type": "Genes/Proteins", "text": [ "IRAK-1" ], "offsets": [ [ 1507, 1513 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s8.e1" } ] }, { "id": "8746", "type": "Genes/Proteins", "text": [ "IRAK-2" ], "offsets": [ [ 1523, 1529 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s8.e2" } ] }, { "id": "8747", "type": "Specific_miRNAs", "text": [ "miRNA-146a" ], "offsets": [ [ 1484, 1494 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s8.e3" } ] }, { "id": "8748", "type": "Specific_miRNAs", "text": [ "miRNA-146a" ], "offsets": [ [ 1722, 1732 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s9.e0" } ] }, { "id": "8749", "type": "Genes/Proteins", "text": [ "NF-κB" ], "offsets": [ [ 1705, 1710 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s9.e1" } ] }, { "id": "8750", "type": "Relation_Trigger", "text": [ "regulation" ], "offsets": [ [ 1599, 1609 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s9.e2" } ] }, { "id": "8751", "type": "Relation_Trigger", "text": [ "down-regulation" ], "offsets": [ [ 1742, 1757 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s9.e3" } ] }, { "id": "8752", "type": "Relation_Trigger", "text": [ "up-regulation" ], "offsets": [ [ 1796, 1809 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s9.e4" } ] }, { "id": "8753", "type": "Genes/Proteins", "text": [ "IRAK-2" ], "offsets": [ [ 1624, 1630 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s9.e5" } ] }, { "id": "8754", "type": "Genes/Proteins", "text": [ "IRAK-1" ], "offsets": [ [ 1613, 1619 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s9.e6" } ] }, { "id": "8755", "type": "Diseases", "text": [ "AD" ], "offsets": [ [ 1634, 1636 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s9.e7" } ] }, { "id": "8756", "type": "Genes/Proteins", "text": [ "IRAK-1" ], "offsets": [ [ 1761, 1767 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s9.e8" } ] }, { "id": "8757", "type": "Genes/Proteins", "text": [ "IRAK-2" ], "offsets": [ [ 1813, 1819 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s9.e9" } ] }, { "id": "8758", "type": "Genes/Proteins", "text": [ "Aβ42" ], "offsets": [ [ 1650, 1654 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s9.e10" } ] }, { "id": "8759", "type": "Genes/Proteins", "text": [ "IL-1" ], "offsets": [ [ 1644, 1648 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s9.e11" } ] }, { "id": "8760", "type": "Specific_miRNAs", "text": [ "miRNA-146a" ], "offsets": [ [ 1934, 1944 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s10.e0" } ] }, { "id": "8761", "type": "Relation_Trigger", "text": [ "inhibitors" ], "offsets": [ [ 1918, 1928 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s10.e1" } ] }, { "id": "8762", "type": "Genes/Proteins", "text": [ "IRAK-2" ], "offsets": [ [ 2042, 2048 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s10.e2" } ] }, { "id": "8763", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 2221, 2227 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s11.e0" } ] }, { "id": "8764", "type": "Specific_miRNAs", "text": [ "miRNA-146a" ], "offsets": [ [ 2120, 2130 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s11.e1" } ] }, { "id": "8765", "type": "Genes/Proteins", "text": [ "IRAK" ], "offsets": [ [ 2248, 2252 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s11.e2" } ] }, { "id": "8766", "type": "Relation_Trigger", "text": [ "regulate brain IRAK expression" ], "offsets": [ [ 2233, 2263 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d181.s11.e3" } ] } ]

[]

[]

[ { "id": "8767", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d181.s0.e4", "arg2_id": "miRNA-corp.d181.s0.e1", "normalized": [] }, { "id": "8768", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d181.s0.e4", "arg2_id": "miRNA-corp.d181.s0.e2", "normalized": [] }, { "id": "8769", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d181.s0.e4", "arg2_id": "miRNA-corp.d181.s0.e3", "normalized": [] }, { "id": "8770", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d181.s0.e4", "arg2_id": "miRNA-corp.d181.s0.e5", "normalized": [] }, { "id": "8771", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d181.s1.e0", "arg2_id": "miRNA-corp.d181.s1.e2", "normalized": [] }, { "id": "8772", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d181.s1.e1", "arg2_id": "miRNA-corp.d181.s1.e2", "normalized": [] }, { "id": "8773", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d181.s2.e2", "arg2_id": "miRNA-corp.d181.s2.e3", "normalized": [] }, { "id": "8774", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d181.s2.e2", "arg2_id": "miRNA-corp.d181.s2.e4", "normalized": [] }, { "id": "8775", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d181.s2.e2", "arg2_id": "miRNA-corp.d181.s2.e5", "normalized": [] }, { "id": "8776", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d181.s4.e6", "arg2_id": "miRNA-corp.d181.s4.e3", "normalized": [] }, { "id": "8777", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d181.s4.e6", "arg2_id": "miRNA-corp.d181.s4.e4", "normalized": [] }, { "id": "8778", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d181.s4.e6", "arg2_id": "miRNA-corp.d181.s4.e5", "normalized": [] }, { "id": "8779", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d181.s5.e8", "arg2_id": "miRNA-corp.d181.s5.e0", "normalized": [] }, { "id": "8780", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d181.s5.e8", "arg2_id": "miRNA-corp.d181.s5.e1", "normalized": [] }, { "id": "8781", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d181.s5.e8", "arg2_id": "miRNA-corp.d181.s5.e2", "normalized": [] }, { "id": "8782", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d181.s5.e8", "arg2_id": "miRNA-corp.d181.s5.e4", "normalized": [] }, { "id": "8783", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d181.s5.e8", "arg2_id": "miRNA-corp.d181.s5.e3", "normalized": [] }, { "id": "8784", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d181.s5.e8", "arg2_id": "miRNA-corp.d181.s5.e5", "normalized": [] }, { "id": "8785", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d181.s5.e8", "arg2_id": "miRNA-corp.d181.s5.e6", "normalized": [] }, { "id": "8786", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d181.s5.e8", "arg2_id": "miRNA-corp.d181.s5.e7", "normalized": [] }, { "id": "8787", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d181.s5.e9", "arg2_id": "miRNA-corp.d181.s5.e0", "normalized": [] }, { "id": "8788", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d181.s5.e9", "arg2_id": "miRNA-corp.d181.s5.e1", "normalized": [] }, { "id": "8789", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d181.s5.e9", "arg2_id": "miRNA-corp.d181.s5.e2", "normalized": [] }, { "id": "8790", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d181.s5.e9", "arg2_id": "miRNA-corp.d181.s5.e4", "normalized": [] }, { "id": "8791", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d181.s5.e9", "arg2_id": "miRNA-corp.d181.s5.e3", "normalized": [] }, { "id": "8792", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d181.s5.e9", "arg2_id": "miRNA-corp.d181.s5.e5", "normalized": [] }, { "id": "8793", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d181.s5.e9", "arg2_id": "miRNA-corp.d181.s5.e6", "normalized": [] }, { "id": "8794", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d181.s5.e9", "arg2_id": "miRNA-corp.d181.s5.e7", "normalized": [] }, { "id": "8795", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d181.s7.e3", "arg2_id": "miRNA-corp.d181.s7.e1", "normalized": [] }, { "id": "8796", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d181.s7.e3", "arg2_id": "miRNA-corp.d181.s7.e2", "normalized": [] }, { "id": "8797", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d181.s8.e3", "arg2_id": "miRNA-corp.d181.s8.e1", "normalized": [] }, { "id": "8798", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d181.s8.e3", "arg2_id": "miRNA-corp.d181.s8.e2", "normalized": [] }, { "id": "8799", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d181.s9.e0", "arg2_id": "miRNA-corp.d181.s9.e5", "normalized": [] }, { "id": "8800", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d181.s9.e0", "arg2_id": "miRNA-corp.d181.s9.e6", "normalized": [] }, { "id": "8801", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d181.s9.e0", "arg2_id": "miRNA-corp.d181.s9.e7", "normalized": [] }, { "id": "8802", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d181.s9.e0", "arg2_id": "miRNA-corp.d181.s9.e1", "normalized": [] }, { "id": "8803", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d181.s9.e0", "arg2_id": "miRNA-corp.d181.s9.e8", "normalized": [] }, { "id": "8804", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d181.s9.e0", "arg2_id": "miRNA-corp.d181.s9.e9", "normalized": [] }, { "id": "8805", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d181.s9.e0", "arg2_id": "miRNA-corp.d181.s9.e10", "normalized": [] }, { "id": "8806", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d181.s9.e0", "arg2_id": "miRNA-corp.d181.s9.e11", "normalized": [] }, { "id": "8807", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d181.s10.e0", "arg2_id": "miRNA-corp.d181.s10.e2", "normalized": [] }, { "id": "8808", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d181.s11.e1", "arg2_id": "miRNA-corp.d181.s11.e2", "normalized": [] }, { "id": "8809", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d181.s11.e0", "arg2_id": "miRNA-corp.d181.s11.e2", "normalized": [] } ]

[ { "id": "8811", "type": "title", "text": [ "MicroRNAs (miRNAs) are short noncoding regulatory RNA molecules that modulate protein expression by inhibiting mRNA translation or promoting mRNA degradation. " ], "offsets": [ [ 0, 159 ] ] }, { "id": "8812", "type": "abstract", "text": [ "miR-34a, a microRNA up-regulated in a double transgenic mouse model of Alzheimer's disease, inhibits bcl2 translation. " ], "offsets": [ [ 160, 280 ] ] }, { "id": "8813", "type": "abstract", "text": [ "During a research for miRNAs that are differentially expressed in cerebral cortex of APPswe/PSDeltaE9 mice (a model for Alzheimer's disease) and age-matched controls, one candidate miRNA that is relatively highly expressed, miR-34a, was studied further because sequence analysis suggested a likely interaction with the 3'-untranslated region of bcl2 mRNA. " ], "offsets": [ [ 281, 637 ] ] }, { "id": "8814", "type": "abstract", "text": [ "However, little is understood about the roles of miRNAs in Alzheimer's disease. " ], "offsets": [ [ 638, 718 ] ] }, { "id": "8815", "type": "abstract", "text": [ "No effect on bcl2 mRNA level was observed. " ], "offsets": [ [ 719, 762 ] ] }, { "id": "8816", "type": "abstract", "text": [ "We show that the expression of miR-34a is inversely correlated with the protein level of bcl2 in APPswe/PSDeltaE9 mice and age-matched controls, and miR-34a expression directly inhibits bcl2 translation in SH-SY5Y cells. " ], "offsets": [ [ 763, 984 ] ] }, { "id": "8817", "type": "abstract", "text": [ "Consistently, miR-34a knockdown through antisense LNA oligonucleotides increased the level of bcl2 protein in SH-SY5Y cells, which was accompanied by a decrease of active caspase-3. " ], "offsets": [ [ 985, 1167 ] ] }, { "id": "8818", "type": "abstract", "text": [ "Western blot analysis of active caspase-3 showed higher levels in APPswe/PSDeltaE9 mice and stable transfecant cell line of miR-34a than in controls. " ], "offsets": [ [ 1168, 1318 ] ] }, { "id": "8819", "type": "abstract", "text": [ "These findings suggested that bcl2 is an important functional target for miR-34a, and the abnormal expression of miR-34a may contribute to the pathogenesis of Alzheimer's disease, at least in part by affecting the expression of bcl2. " ], "offsets": [ [ 1319, 1555 ] ] } ]

[ { "id": "8820", "type": "Non-Specific_miRNAs", "text": [ "MicroRNAs" ], "offsets": [ [ 0, 9 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d182.s0.e0" } ] }, { "id": "8821", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 11, 17 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d182.s0.e1" } ] }, { "id": "8822", "type": "Relation_Trigger", "text": [ "inhibiting mRNA translation" ], "offsets": [ [ 100, 127 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d182.s0.e2" } ] }, { "id": "8823", "type": "Relation_Trigger", "text": [ "regulatory RNA molecules that modulate protein expression" ], "offsets": [ [ 39, 96 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d182.s0.e3" } ] }, { "id": "8824", "type": "Specific_miRNAs", "text": [ "miR-34a" ], "offsets": [ [ 160, 167 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d182.s1.e0" } ] }, { "id": "8825", "type": "Diseases", "text": [ "Alzheimer's disease" ], "offsets": [ [ 231, 250 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d182.s1.e1" } ] }, { "id": "8826", "type": "Genes/Proteins", "text": [ "bcl2" ], "offsets": [ [ 261, 265 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d182.s1.e2" } ] }, { "id": "8827", "type": "Non-Specific_miRNAs", "text": [ "microRNA" ], "offsets": [ [ 171, 179 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d182.s1.e3" } ] }, { "id": "8828", "type": "Relation_Trigger", "text": [ "up-regulated" ], "offsets": [ [ 180, 192 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d182.s1.e4" } ] }, { "id": "8829", "type": "Relation_Trigger", "text": [ "inhibits bcl2 translation" ], "offsets": [ [ 252, 277 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d182.s1.e5" } ] }, { "id": "8830", "type": "Species", "text": [ "mouse" ], "offsets": [ [ 216, 221 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d182.s1.e6" } ] }, { "id": "8831", "type": "Diseases", "text": [ "Alzheimer's disease" ], "offsets": [ [ 401, 420 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d182.s2.e0" } ] }, { "id": "8832", "type": "Specific_miRNAs", "text": [ "miR-34a" ], "offsets": [ [ 505, 512 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d182.s2.e1" } ] }, { "id": "8833", "type": "Genes/Proteins", "text": [ "bcl2" ], "offsets": [ [ 626, 630 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d182.s2.e2" } ] }, { "id": "8834", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 303, 309 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d182.s2.e3" } ] }, { "id": "8835", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 462, 467 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d182.s2.e4" } ] }, { "id": "8836", "type": "Relation_Trigger", "text": [ "highly expressed" ], "offsets": [ [ 487, 503 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d182.s2.e5" } ] }, { "id": "8837", "type": "Relation_Trigger", "text": [ "differentially expressed" ], "offsets": [ [ 319, 343 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d182.s2.e6" } ] }, { "id": "8838", "type": "Relation_Trigger", "text": [ "interaction with the 3'-untranslated region" ], "offsets": [ [ 579, 622 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d182.s2.e7" } ] }, { "id": "8839", "type": "Species", "text": [ "mice" ], "offsets": [ [ 383, 387 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d182.s2.e8" } ] }, { "id": "8840", "type": "Diseases", "text": [ "Alzheimer's disease" ], "offsets": [ [ 697, 716 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d182.s3.e0" } ] }, { "id": "8841", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 687, 693 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d182.s3.e1" } ] }, { "id": "8842", "type": "Genes/Proteins", "text": [ "bcl2" ], "offsets": [ [ 732, 736 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d182.s4.e0" } ] }, { "id": "8843", "type": "Specific_miRNAs", "text": [ "miR-34a" ], "offsets": [ [ 794, 801 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d182.s5.e0" } ] }, { "id": "8844", "type": "Specific_miRNAs", "text": [ "miR-34a" ], "offsets": [ [ 912, 919 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d182.s5.e1" } ] }, { "id": "8845", "type": "Genes/Proteins", "text": [ "bcl2" ], "offsets": [ [ 852, 856 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d182.s5.e2" } ] }, { "id": "8846", "type": "Genes/Proteins", "text": [ "bcl2" ], "offsets": [ [ 949, 953 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d182.s5.e3" } ] }, { "id": "8847", "type": "Relation_Trigger", "text": [ "inversely correlated" ], "offsets": [ [ 805, 825 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d182.s5.e4" } ] }, { "id": "8848", "type": "Relation_Trigger", "text": [ "expression directly inhibits" ], "offsets": [ [ 920, 948 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d182.s5.e5" } ] }, { "id": "8849", "type": "Relation_Trigger", "text": [ "inhibits bcl2 translation" ], "offsets": [ [ 940, 965 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d182.s5.e6" } ] }, { "id": "8850", "type": "Species", "text": [ "mice" ], "offsets": [ [ 877, 881 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d182.s5.e7" } ] }, { "id": "8851", "type": "Genes/Proteins", "text": [ "bcl2" ], "offsets": [ [ 1079, 1083 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d182.s6.e0" } ] }, { "id": "8852", "type": "Specific_miRNAs", "text": [ "miR-34a" ], "offsets": [ [ 999, 1006 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d182.s6.e1" } ] }, { "id": "8853", "type": "Genes/Proteins", "text": [ "caspase-3" ], "offsets": [ [ 1156, 1165 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d182.s6.e2" } ] }, { "id": "8854", "type": "Relation_Trigger", "text": [ "decrease of active" ], "offsets": [ [ 1137, 1155 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d182.s6.e3" } ] }, { "id": "8855", "type": "Relation_Trigger", "text": [ "increased the level of bcl2 protein" ], "offsets": [ [ 1056, 1091 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d182.s6.e4" } ] }, { "id": "8856", "type": "Specific_miRNAs", "text": [ "miR-34a" ], "offsets": [ [ 1292, 1299 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d182.s7.e0" } ] }, { "id": "8857", "type": "Genes/Proteins", "text": [ "caspase-3" ], "offsets": [ [ 1200, 1209 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d182.s7.e1" } ] }, { "id": "8858", "type": "Relation_Trigger", "text": [ "higher levels" ], "offsets": [ [ 1217, 1230 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d182.s7.e2" } ] }, { "id": "8859", "type": "Species", "text": [ "mice" ], "offsets": [ [ 1251, 1255 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d182.s7.e3" } ] }, { "id": "8860", "type": "Specific_miRNAs", "text": [ "miR-34a" ], "offsets": [ [ 1392, 1399 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d182.s8.e0" } ] }, { "id": "8861", "type": "Specific_miRNAs", "text": [ "miR-34a" ], "offsets": [ [ 1432, 1439 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d182.s8.e1" } ] }, { "id": "8862", "type": "Genes/Proteins", "text": [ "bcl2" ], "offsets": [ [ 1349, 1353 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d182.s8.e2" } ] }, { "id": "8863", "type": "Diseases", "text": [ "Alzheimer's disease" ], "offsets": [ [ 1478, 1497 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d182.s8.e3" } ] }, { "id": "8864", "type": "Genes/Proteins", "text": [ "bcl2" ], "offsets": [ [ 1547, 1551 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d182.s8.e4" } ] }, { "id": "8865", "type": "Relation_Trigger", "text": [ "functional target" ], "offsets": [ [ 1370, 1387 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d182.s8.e5" } ] }, { "id": "8866", "type": "Relation_Trigger", "text": [ "abnormal expression" ], "offsets": [ [ 1409, 1428 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d182.s8.e6" } ] }, { "id": "8867", "type": "Relation_Trigger", "text": [ "affecting the expression" ], "offsets": [ [ 1519, 1543 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d182.s8.e7" } ] } ]

[]

[]

[ { "id": "8868", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d182.s1.e0", "arg2_id": "miRNA-corp.d182.s1.e1", "normalized": [] }, { "id": "8869", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d182.s1.e0", "arg2_id": "miRNA-corp.d182.s1.e2", "normalized": [] }, { "id": "8870", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d182.s1.e3", "arg2_id": "miRNA-corp.d182.s1.e1", "normalized": [] }, { "id": "8871", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d182.s1.e3", "arg2_id": "miRNA-corp.d182.s1.e2", "normalized": [] }, { "id": "8872", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d182.s2.e3", "arg2_id": "miRNA-corp.d182.s2.e0", "normalized": [] }, { "id": "8873", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d182.s2.e3", "arg2_id": "miRNA-corp.d182.s2.e2", "normalized": [] }, { "id": "8874", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d182.s2.e4", "arg2_id": "miRNA-corp.d182.s2.e0", "normalized": [] }, { "id": "8875", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d182.s2.e4", "arg2_id": "miRNA-corp.d182.s2.e2", "normalized": [] }, { "id": "8876", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d182.s2.e1", "arg2_id": "miRNA-corp.d182.s2.e0", "normalized": [] }, { "id": "8877", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d182.s2.e1", "arg2_id": "miRNA-corp.d182.s2.e2", "normalized": [] }, { "id": "8878", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d182.s3.e1", "arg2_id": "miRNA-corp.d182.s3.e0", "normalized": [] }, { "id": "8879", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d182.s5.e0", "arg2_id": "miRNA-corp.d182.s5.e2", "normalized": [] }, { "id": "8880", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d182.s5.e0", "arg2_id": "miRNA-corp.d182.s5.e3", "normalized": [] }, { "id": "8881", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d182.s5.e1", "arg2_id": "miRNA-corp.d182.s5.e2", "normalized": [] }, { "id": "8882", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d182.s5.e1", "arg2_id": "miRNA-corp.d182.s5.e3", "normalized": [] }, { "id": "8883", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d182.s6.e1", "arg2_id": "miRNA-corp.d182.s6.e0", "normalized": [] }, { "id": "8884", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d182.s6.e1", "arg2_id": "miRNA-corp.d182.s6.e2", "normalized": [] }, { "id": "8885", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d182.s7.e0", "arg2_id": "miRNA-corp.d182.s7.e1", "normalized": [] }, { "id": "8886", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d182.s8.e0", "arg2_id": "miRNA-corp.d182.s8.e2", "normalized": [] }, { "id": "8887", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d182.s8.e0", "arg2_id": "miRNA-corp.d182.s8.e3", "normalized": [] }, { "id": "8888", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d182.s8.e0", "arg2_id": "miRNA-corp.d182.s8.e4", "normalized": [] }, { "id": "8889", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d182.s8.e1", "arg2_id": "miRNA-corp.d182.s8.e2", "normalized": [] }, { "id": "8890", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d182.s8.e1", "arg2_id": "miRNA-corp.d182.s8.e3", "normalized": [] }, { "id": "8891", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d182.s8.e1", "arg2_id": "miRNA-corp.d182.s8.e4", "normalized": [] } ]

[ { "id": "8893", "type": "title", "text": [ "Therein lies the therapeutic potential of miRNA, as it may now be possible to induce or inhibit RNAi in a given diseased cell population by controlling the cells' miRNA expression profile. " ], "offsets": [ [ 0, 189 ] ] }, { "id": "8894", "type": "abstract", "text": [ "This review outlines the potential of miRNA as a therapeutic strategy against high-grade gliomas, and also the technological hurdles that need to be addressed before this promising technique can be administered in a clinical setting. " ], "offsets": [ [ 190, 426 ] ] }, { "id": "8895", "type": "abstract", "text": [ "Thus, miRNA can be considered the cells' answer to siRNA. " ], "offsets": [ [ 427, 485 ] ] }, { "id": "8896", "type": "abstract", "text": [ "Discovered over a decade ago, miRNA is fast becoming recognized as crucial in regulating gene expression in cancers. " ], "offsets": [ [ 486, 603 ] ] }, { "id": "8897", "type": "abstract", "text": [ "Malignant brain tumors, including high-grade gliomas, are among the most lethal of all cancers. " ], "offsets": [ [ 604, 700 ] ] }, { "id": "8898", "type": "abstract", "text": [ "MicroRNA and brain tumors: a cause and a cure? " ], "offsets": [ [ 701, 749 ] ] }, { "id": "8899", "type": "abstract", "text": [ "MicroRNA (miRNA), an endogenously expressed form of siRNA, not only presents an alternate method to induce RNAi in a given diseased tissue or organ, but also exposes a unique set of diagnostic markers that can be used to identify, and then differentiate between tumor grades. " ], "offsets": [ [ 750, 1026 ] ] }, { "id": "8900", "type": "abstract", "text": [ "However, practical difficulties in tissue- or organ-specific targeting of therapeutic quantities of siRNA still preclude its applicability in a clinical setting. " ], "offsets": [ [ 1027, 1189 ] ] }, { "id": "8901", "type": "abstract", "text": [ "With the discovery of RNA interference (RNAi) for target-specific gene silencing via small interfering RNA (siRNA), a novel method to target malignant gliomas has been exposed, an endeavor that is aggressively being carried out in numerous laboratories. " ], "offsets": [ [ 1190, 1444 ] ] }, { "id": "8902", "type": "abstract", "text": [ "Despite considerable advances, including multi-modal treatments with surgery, radiotherapy, and chemotherapy, the overall prognosis remains dismal for patients diagnosed with these tumors. " ], "offsets": [ [ 1445, 1634 ] ] } ]

[ { "id": "8903", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 42, 47 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d183.s0.e0" } ] }, { "id": "8904", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 163, 168 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d183.s0.e1" } ] }, { "id": "8905", "type": "Relation_Trigger", "text": [ "inhibit" ], "offsets": [ [ 88, 95 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d183.s0.e2" } ] }, { "id": "8906", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 228, 233 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d183.s1.e0" } ] }, { "id": "8907", "type": "Diseases", "text": [ "high-grade gliomas" ], "offsets": [ [ 268, 286 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d183.s1.e1" } ] }, { "id": "8908", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 433, 438 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d183.s2.e0" } ] }, { "id": "8909", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 516, 521 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d183.s3.e0" } ] }, { "id": "8910", "type": "Relation_Trigger", "text": [ "regulating gene expression" ], "offsets": [ [ 564, 590 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d183.s3.e1" } ] }, { "id": "8911", "type": "Diseases", "text": [ "cancers" ], "offsets": [ [ 594, 601 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d183.s3.e2" } ] }, { "id": "8912", "type": "Diseases", "text": [ "brain tumors" ], "offsets": [ [ 614, 626 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d183.s4.e0" } ] }, { "id": "8913", "type": "Diseases", "text": [ "high-grade gliomas" ], "offsets": [ [ 638, 656 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d183.s4.e1" } ] }, { "id": "8914", "type": "Diseases", "text": [ "cancers" ], "offsets": [ [ 691, 698 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d183.s4.e2" } ] }, { "id": "8915", "type": "Non-Specific_miRNAs", "text": [ "MicroRNA" ], "offsets": [ [ 701, 709 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d183.s5.e0" } ] }, { "id": "8916", "type": "Diseases", "text": [ "brain tumors" ], "offsets": [ [ 714, 726 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d183.s5.e1" } ] }, { "id": "8917", "type": "Non-Specific_miRNAs", "text": [ "MicroRNA" ], "offsets": [ [ 750, 758 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d183.s6.e0" } ] }, { "id": "8918", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 760, 765 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d183.s6.e1" } ] }, { "id": "8919", "type": "Diseases", "text": [ "tumor" ], "offsets": [ [ 1012, 1017 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d183.s6.e2" } ] }, { "id": "8920", "type": "Relation_Trigger", "text": [ "targeting" ], "offsets": [ [ 1088, 1097 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d183.s7.e0" } ] }, { "id": "8921", "type": "Diseases", "text": [ "malignant gliomas" ], "offsets": [ [ 1331, 1348 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d183.s8.e0" } ] }, { "id": "8922", "type": "Relation_Trigger", "text": [ "target" ], "offsets": [ [ 1324, 1330 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d183.s8.e1" } ] }, { "id": "8923", "type": "Diseases", "text": [ "tumors" ], "offsets": [ [ 1626, 1632 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d183.s9.e0" } ] }, { "id": "8924", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1596, 1604 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d183.s9.e1" } ] } ]

[]

[]

[ { "id": "8925", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d183.s1.e0", "arg2_id": "miRNA-corp.d183.s1.e1", "normalized": [] }, { "id": "8926", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d183.s3.e0", "arg2_id": "miRNA-corp.d183.s3.e2", "normalized": [] }, { "id": "8927", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d183.s5.e0", "arg2_id": "miRNA-corp.d183.s5.e1", "normalized": [] }, { "id": "8928", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d183.s6.e0", "arg2_id": "miRNA-corp.d183.s6.e2", "normalized": [] }, { "id": "8929", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d183.s6.e1", "arg2_id": "miRNA-corp.d183.s6.e2", "normalized": [] } ]

[ { "id": "8931", "type": "title", "text": [ "The relative expression of miRNAs was measured by real-time PCR using RNU44 and RNU49 as endogenous controls. " ], "offsets": [ [ 0, 110 ] ] }, { "id": "8932", "type": "abstract", "text": [ "Relative quantification of miRNA expression was calculated using the 2(-DeltaDeltaCt) method. " ], "offsets": [ [ 111, 205 ] ] }, { "id": "8933", "type": "abstract", "text": [ "Objective: The aim of the study was to analyze the differential expression of let-7a, miR-15a, miR-16, miR-21, miR-141, miR-143, miR-145, and miR-150 in corticotropinomas and normal pituitary tissue and verify whether their profile of expression correlates with tumor size or remission after treatment. " ], "offsets": [ [ 206, 509 ] ] }, { "id": "8934", "type": "abstract", "text": [ "MATERIAL AND METHODS: ACTH-secreting pituitary tumor samples were obtained during transphenoidal surgery from patients with Cushing disease and normal pituitary tissues from autopsies. " ], "offsets": [ [ 510, 695 ] ] }, { "id": "8935", "type": "abstract", "text": [ "CONCLUSION: Our results support the possibility that altered miRNA expression profile might be involved in corticotrophic tumorigenesis. " ], "offsets": [ [ 696, 833 ] ] }, { "id": "8936", "type": "abstract", "text": [ "RESULTS: We found underexpression of miR-145 (2.0-fold; P = 0.04), miR-21 (2.4-fold; P = 0.004), miR-141 (2.6-fold; P = 0.02), let-7a (3.3-fold; P = 0.003), miR-150 (3.8-fold; P = 0.04), miR-15a (4.5-fold; P = 0.03), miR-16 (5.0-fold; P = 0.004), and miR-143 (6.4-fold; P = 0.004) in ACTH-secreting pituitary tumors when compared to normal pituitary tissues. " ], "offsets": [ [ 834, 1193 ] ] }, { "id": "8937", "type": "abstract", "text": [ "There were no differences between miRNA expression and tumor size as well as miRNA expression and ratio of remission after surgery, except in patients presenting lower miR-141 expression who showed a better chance of remission. " ], "offsets": [ [ 1194, 1422 ] ] }, { "id": "8938", "type": "abstract", "text": [ "MicroRNAs differentially expressed in ACTH-secreting pituitary tumors. " ], "offsets": [ [ 1423, 1495 ] ] }, { "id": "8939", "type": "abstract", "text": [ "More than 50% of miRNA genes are located in cancer-associated genomic regions or in fragile sites of the genome. " ], "offsets": [ [ 1496, 1609 ] ] }, { "id": "8940", "type": "abstract", "text": [ "CONTEXT: MicroRNAs (miRNAs) are small noncoding RNAs, functioning as antisense regulators of gene expression by targeting mRNA and contributing to cancer development and progression. " ], "offsets": [ [ 1610, 1793 ] ] }, { "id": "8941", "type": "abstract", "text": [ "However, the lack of knowledge about miRNA target genes postpones full understanding of the biological functions of down-regulated or up-regulated miRNAs in corticotropinomas. " ], "offsets": [ [ 1794, 1972 ] ] } ]

[ { "id": "8942", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 27, 33 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s0.e0" } ] }, { "id": "8943", "type": "Genes/Proteins", "text": [ "RNU44" ], "offsets": [ [ 70, 75 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s0.e1" } ] }, { "id": "8944", "type": "Genes/Proteins", "text": [ "RNU49" ], "offsets": [ [ 80, 85 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s0.e2" } ] }, { "id": "8945", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 138, 143 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s1.e0" } ] }, { "id": "8946", "type": "Specific_miRNAs", "text": [ "let-7a" ], "offsets": [ [ 284, 290 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s2.e0" } ] }, { "id": "8947", "type": "Specific_miRNAs", "text": [ "miR-15a" ], "offsets": [ [ 292, 299 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s2.e1" } ] }, { "id": "8948", "type": "Specific_miRNAs", "text": [ "miR-16" ], "offsets": [ [ 301, 307 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s2.e2" } ] }, { "id": "8949", "type": "Specific_miRNAs", "text": [ "miR-21" ], "offsets": [ [ 309, 315 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s2.e3" } ] }, { "id": "8950", "type": "Specific_miRNAs", "text": [ "miR-141" ], "offsets": [ [ 317, 324 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s2.e4" } ] }, { "id": "8951", "type": "Specific_miRNAs", "text": [ "miR-143" ], "offsets": [ [ 326, 333 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s2.e5" } ] }, { "id": "8952", "type": "Specific_miRNAs", "text": [ "miR-145" ], "offsets": [ [ 335, 342 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s2.e6" } ] }, { "id": "8953", "type": "Specific_miRNAs", "text": [ "miR-150" ], "offsets": [ [ 348, 355 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s2.e7" } ] }, { "id": "8954", "type": "Diseases", "text": [ "corticotropinomas" ], "offsets": [ [ 359, 376 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s2.e8" } ] }, { "id": "8955", "type": "Relation_Trigger", "text": [ "differential expression" ], "offsets": [ [ 257, 280 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s2.e9" } ] }, { "id": "8956", "type": "Relation_Trigger", "text": [ "expression correlates" ], "offsets": [ [ 441, 462 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s2.e10" } ] }, { "id": "8957", "type": "Diseases", "text": [ "tumor" ], "offsets": [ [ 468, 473 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s2.e11" } ] }, { "id": "8958", "type": "Diseases", "text": [ "Cushing disease" ], "offsets": [ [ 634, 649 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s3.e0" } ] }, { "id": "8959", "type": "Diseases", "text": [ "ACTH-secreting pituitary tumor" ], "offsets": [ [ 532, 562 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s3.e1" } ] }, { "id": "8960", "type": "Species", "text": [ "patients" ], "offsets": [ [ 620, 628 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s3.e2" } ] }, { "id": "8961", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 757, 762 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s4.e0" } ] }, { "id": "8962", "type": "Relation_Trigger", "text": [ "altered miRNA expression profile" ], "offsets": [ [ 749, 781 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s4.e1" } ] }, { "id": "8963", "type": "Specific_miRNAs", "text": [ "miR-145" ], "offsets": [ [ 871, 878 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s5.e0" } ] }, { "id": "8964", "type": "Specific_miRNAs", "text": [ "miR-21" ], "offsets": [ [ 901, 907 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s5.e1" } ] }, { "id": "8965", "type": "Specific_miRNAs", "text": [ "miR-150" ], "offsets": [ [ 991, 998 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s5.e2" } ] }, { "id": "8966", "type": "Specific_miRNAs", "text": [ "let-7a" ], "offsets": [ [ 961, 967 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s5.e3" } ] }, { "id": "8967", "type": "Specific_miRNAs", "text": [ "miR-16" ], "offsets": [ [ 1051, 1057 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s5.e4" } ] }, { "id": "8968", "type": "Specific_miRNAs", "text": [ "miR-15a" ], "offsets": [ [ 1021, 1028 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s5.e5" } ] }, { "id": "8969", "type": "Specific_miRNAs", "text": [ "miR-141" ], "offsets": [ [ 931, 938 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s5.e6" } ] }, { "id": "8970", "type": "Specific_miRNAs", "text": [ "miR-143" ], "offsets": [ [ 1085, 1092 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s5.e7" } ] }, { "id": "8971", "type": "Relation_Trigger", "text": [ "underexpression" ], "offsets": [ [ 852, 867 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s5.e8" } ] }, { "id": "8972", "type": "Diseases", "text": [ "ACTH-secreting pituitary tumors" ], "offsets": [ [ 1118, 1149 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s5.e9" } ] }, { "id": "8973", "type": "Specific_miRNAs", "text": [ "miR-141" ], "offsets": [ [ 1362, 1369 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s6.e0" } ] }, { "id": "8974", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1228, 1233 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s6.e1" } ] }, { "id": "8975", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1271, 1276 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s6.e2" } ] }, { "id": "8976", "type": "Relation_Trigger", "text": [ "lower miR-141 expression" ], "offsets": [ [ 1356, 1380 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s6.e3" } ] }, { "id": "8977", "type": "Diseases", "text": [ "tumor" ], "offsets": [ [ 1249, 1254 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s6.e4" } ] }, { "id": "8978", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1336, 1344 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s6.e5" } ] }, { "id": "8979", "type": "Non-Specific_miRNAs", "text": [ "MicroRNAs" ], "offsets": [ [ 1423, 1432 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s7.e0" } ] }, { "id": "8980", "type": "Relation_Trigger", "text": [ "differentially expressed" ], "offsets": [ [ 1433, 1457 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s7.e1" } ] }, { "id": "8981", "type": "Diseases", "text": [ "ACTH-secreting pituitary tumors" ], "offsets": [ [ 1461, 1492 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s7.e2" } ] }, { "id": "8982", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1513, 1518 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s8.e0" } ] }, { "id": "8983", "type": "Diseases", "text": [ "cancer" ], "offsets": [ [ 1540, 1546 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s8.e1" } ] }, { "id": "8984", "type": "Non-Specific_miRNAs", "text": [ "MicroRNAs" ], "offsets": [ [ 1619, 1628 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s9.e0" } ] }, { "id": "8985", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1630, 1636 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s9.e1" } ] }, { "id": "8986", "type": "Relation_Trigger", "text": [ "regulators of gene expression" ], "offsets": [ [ 1689, 1718 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s9.e2" } ] }, { "id": "8987", "type": "Relation_Trigger", "text": [ "targeting" ], "offsets": [ [ 1722, 1731 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s9.e3" } ] }, { "id": "8988", "type": "Diseases", "text": [ "cancer" ], "offsets": [ [ 1757, 1763 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s9.e4" } ] }, { "id": "8989", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1831, 1836 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s10.e0" } ] }, { "id": "8990", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1941, 1947 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s10.e1" } ] }, { "id": "8991", "type": "Diseases", "text": [ "corticotropinomas" ], "offsets": [ [ 1951, 1968 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s10.e2" } ] }, { "id": "8992", "type": "Relation_Trigger", "text": [ "down-regulated" ], "offsets": [ [ 1910, 1924 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s10.e3" } ] }, { "id": "8993", "type": "Relation_Trigger", "text": [ "up-regulated" ], "offsets": [ [ 1928, 1940 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s10.e4" } ] }, { "id": "8994", "type": "Relation_Trigger", "text": [ "target" ], "offsets": [ [ 1837, 1843 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d184.s10.e5" } ] } ]

[]

[]

[ { "id": "8995", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d184.s0.e0", "arg2_id": "miRNA-corp.d184.s0.e1", "normalized": [] }, { "id": "8996", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d184.s0.e0", "arg2_id": "miRNA-corp.d184.s0.e2", "normalized": [] }, { "id": "8997", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d184.s2.e0", "arg2_id": "miRNA-corp.d184.s2.e8", "normalized": [] }, { "id": "8998", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d184.s2.e0", "arg2_id": "miRNA-corp.d184.s2.e11", "normalized": [] }, { "id": "8999", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d184.s2.e1", "arg2_id": "miRNA-corp.d184.s2.e8", "normalized": [] }, { "id": "9000", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d184.s2.e1", "arg2_id": "miRNA-corp.d184.s2.e11", "normalized": [] }, { "id": "9001", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d184.s2.e2", "arg2_id": "miRNA-corp.d184.s2.e8", "normalized": [] }, { "id": "9002", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d184.s2.e2", "arg2_id": "miRNA-corp.d184.s2.e11", "normalized": [] }, { "id": "9003", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d184.s2.e7", "arg2_id": "miRNA-corp.d184.s2.e8", "normalized": [] }, { "id": "9004", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d184.s2.e7", "arg2_id": "miRNA-corp.d184.s2.e11", "normalized": [] }, { "id": "9005", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d184.s2.e3", "arg2_id": "miRNA-corp.d184.s2.e8", "normalized": [] }, { "id": "9006", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d184.s2.e3", "arg2_id": "miRNA-corp.d184.s2.e11", "normalized": [] }, { "id": "9007", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d184.s2.e4", "arg2_id": "miRNA-corp.d184.s2.e8", "normalized": [] }, { "id": "9008", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d184.s2.e4", "arg2_id": "miRNA-corp.d184.s2.e11", "normalized": [] }, { "id": "9009", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d184.s2.e5", "arg2_id": "miRNA-corp.d184.s2.e8", "normalized": [] }, { "id": "9010", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d184.s2.e5", "arg2_id": "miRNA-corp.d184.s2.e11", "normalized": [] }, { "id": "9011", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d184.s2.e6", "arg2_id": "miRNA-corp.d184.s2.e8", "normalized": [] }, { "id": "9012", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d184.s2.e6", "arg2_id": "miRNA-corp.d184.s2.e11", "normalized": [] }, { "id": "9013", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d184.s5.e3", "arg2_id": "miRNA-corp.d184.s5.e9", "normalized": [] }, { "id": "9014", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d184.s5.e4", "arg2_id": "miRNA-corp.d184.s5.e9", "normalized": [] }, { "id": "9015", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d184.s5.e5", "arg2_id": "miRNA-corp.d184.s5.e9", "normalized": [] }, { "id": "9016", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d184.s5.e6", "arg2_id": "miRNA-corp.d184.s5.e9", "normalized": [] }, { "id": "9017", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d184.s5.e7", "arg2_id": "miRNA-corp.d184.s5.e9", "normalized": [] }, { "id": "9018", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d184.s5.e0", "arg2_id": "miRNA-corp.d184.s5.e9", "normalized": [] }, { "id": "9019", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d184.s5.e1", "arg2_id": "miRNA-corp.d184.s5.e9", "normalized": [] }, { "id": "9020", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d184.s5.e2", "arg2_id": "miRNA-corp.d184.s5.e9", "normalized": [] }, { "id": "9021", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d184.s6.e0", "arg2_id": "miRNA-corp.d184.s6.e4", "normalized": [] }, { "id": "9022", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d184.s6.e1", "arg2_id": "miRNA-corp.d184.s6.e4", "normalized": [] }, { "id": "9023", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d184.s6.e2", "arg2_id": "miRNA-corp.d184.s6.e4", "normalized": [] }, { "id": "9024", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d184.s7.e0", "arg2_id": "miRNA-corp.d184.s7.e2", "normalized": [] }, { "id": "9025", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d184.s8.e0", "arg2_id": "miRNA-corp.d184.s8.e1", "normalized": [] }, { "id": "9026", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d184.s9.e0", "arg2_id": "miRNA-corp.d184.s9.e4", "normalized": [] }, { "id": "9027", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d184.s9.e1", "arg2_id": "miRNA-corp.d184.s9.e4", "normalized": [] }, { "id": "9028", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d184.s10.e0", "arg2_id": "miRNA-corp.d184.s10.e2", "normalized": [] }, { "id": "9029", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d184.s10.e1", "arg2_id": "miRNA-corp.d184.s10.e2", "normalized": [] } ]

[ { "id": "9031", "type": "title", "text": [ "Brain and blood microRNA expression profiling of ischemic stroke, intracerebral hemorrhage, and kainate seizures. " ], "offsets": [ [ 0, 115 ] ] }, { "id": "9032", "type": "abstract", "text": [ "MicroRNAs (miRNAs) regulate gene expression and have a critical role in many biologic and pathologic processes. " ], "offsets": [ [ 116, 228 ] ] }, { "id": "9033", "type": "abstract", "text": [ "The results show the possible use of blood miRNAs as biomarkers for brain injury; that selected blood miRNAs may correlate with miRNA changes in the brain; and that many of the mRNAs, previously shown to be regulated in brain and blood after brain injury, are likely accounted for by changes in miRNA expression. " ], "offsets": [ [ 229, 544 ] ] }, { "id": "9034", "type": "abstract", "text": [ "A few miRNAs (e.g., miR-298, miR-155, and miR-362-3p) were upregulated or downregulated more than twofold in both brain and blood after several different injuries. " ], "offsets": [ [ 545, 709 ] ] }, { "id": "9035", "type": "abstract", "text": [ "Many miRNAs changed more than 1.5-fold in brain and blood after each experimental manipulation, and several miRNAs were upregulated or downregulated in both brain and blood after a given injury. " ], "offsets": [ [ 710, 905 ] ] }, { "id": "9036", "type": "abstract", "text": [ "MicroRNA response profiles were different for each condition. " ], "offsets": [ [ 906, 968 ] ] }, { "id": "9037", "type": "abstract", "text": [ "Brain and whole-blood miRNA expression profiles were assessed 24 h later using TaqMan rodent miRNA arrays. " ], "offsets": [ [ 969, 1076 ] ] }, { "id": "9038", "type": "abstract", "text": [ "Adult, untouched, control rats were compared with rats with sham surgeries, ischemic strokes, brain hemorrhage (lysed blood, fresh blood, or thrombin), and kainate-induced seizures. " ], "offsets": [ [ 1077, 1259 ] ] }, { "id": "9039", "type": "abstract", "text": [ "We hypothesized that miRNA expression profiles in injured brain (hippocampus) would show common as well as unique profiles when compared with those of blood. " ], "offsets": [ [ 1260, 1418 ] ] } ]

[ { "id": "9040", "type": "Diseases", "text": [ "intracerebral hemorrhage" ], "offsets": [ [ 66, 90 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d185.s0.e0" } ] }, { "id": "9041", "type": "Non-Specific_miRNAs", "text": [ "microRNA" ], "offsets": [ [ 16, 24 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d185.s0.e1" } ] }, { "id": "9042", "type": "Diseases", "text": [ "ischemic stroke" ], "offsets": [ [ 49, 64 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d185.s0.e2" } ] }, { "id": "9043", "type": "Diseases", "text": [ "kainate seizures" ], "offsets": [ [ 96, 112 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d185.s0.e3" } ] }, { "id": "9044", "type": "Non-Specific_miRNAs", "text": [ "MicroRNAs" ], "offsets": [ [ 116, 125 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d185.s1.e0" } ] }, { "id": "9045", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 127, 133 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d185.s1.e1" } ] }, { "id": "9046", "type": "Relation_Trigger", "text": [ "regulate gene expression" ], "offsets": [ [ 135, 159 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d185.s1.e2" } ] }, { "id": "9047", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 272, 278 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d185.s2.e0" } ] }, { "id": "9048", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 331, 337 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d185.s2.e1" } ] }, { "id": "9049", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 357, 362 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d185.s2.e2" } ] }, { "id": "9050", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 524, 529 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d185.s2.e3" } ] }, { "id": "9051", "type": "Diseases", "text": [ "brain injury" ], "offsets": [ [ 471, 483 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d185.s2.e4" } ] }, { "id": "9052", "type": "Diseases", "text": [ "brain injury" ], "offsets": [ [ 297, 309 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d185.s2.e5" } ] }, { "id": "9053", "type": "Relation_Trigger", "text": [ "changes in miRNA expression" ], "offsets": [ [ 513, 540 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d185.s2.e6" } ] }, { "id": "9054", "type": "Relation_Trigger", "text": [ "correlate" ], "offsets": [ [ 342, 351 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d185.s2.e7" } ] }, { "id": "9055", "type": "Relation_Trigger", "text": [ "regulated" ], "offsets": [ [ 436, 445 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d185.s2.e8" } ] }, { "id": "9056", "type": "Specific_miRNAs", "text": [ "miR-298" ], "offsets": [ [ 565, 572 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d185.s3.e0" } ] }, { "id": "9057", "type": "Specific_miRNAs", "text": [ "miR-155" ], "offsets": [ [ 574, 581 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d185.s3.e1" } ] }, { "id": "9058", "type": "Specific_miRNAs", "text": [ "miR-362-3p" ], "offsets": [ [ 587, 597 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d185.s3.e2" } ] }, { "id": "9059", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 551, 557 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d185.s3.e3" } ] }, { "id": "9060", "type": "Diseases", "text": [ "injuries" ], "offsets": [ [ 699, 707 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d185.s3.e4" } ] }, { "id": "9061", "type": "Relation_Trigger", "text": [ "upregulated" ], "offsets": [ [ 604, 615 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d185.s3.e5" } ] }, { "id": "9062", "type": "Relation_Trigger", "text": [ "downregulated" ], "offsets": [ [ 619, 632 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d185.s3.e6" } ] }, { "id": "9063", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 715, 721 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d185.s4.e0" } ] }, { "id": "9064", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 818, 824 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d185.s4.e1" } ] }, { "id": "9065", "type": "Relation_Trigger", "text": [ "downregulated" ], "offsets": [ [ 845, 858 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d185.s4.e2" } ] }, { "id": "9066", "type": "Diseases", "text": [ "injury" ], "offsets": [ [ 897, 903 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d185.s4.e3" } ] }, { "id": "9067", "type": "Relation_Trigger", "text": [ "upregulated" ], "offsets": [ [ 830, 841 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d185.s4.e4" } ] }, { "id": "9068", "type": "Non-Specific_miRNAs", "text": [ "MicroRNA" ], "offsets": [ [ 906, 914 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d185.s5.e0" } ] }, { "id": "9069", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1062, 1067 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d185.s6.e0" } ] }, { "id": "9070", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 991, 996 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d185.s6.e1" } ] }, { "id": "9071", "type": "Diseases", "text": [ "brain hemorrhage" ], "offsets": [ [ 1171, 1187 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d185.s7.e0" } ] }, { "id": "9072", "type": "Diseases", "text": [ "ischemic strokes" ], "offsets": [ [ 1153, 1169 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d185.s7.e1" } ] }, { "id": "9073", "type": "Diseases", "text": [ "kainate-induced seizures" ], "offsets": [ [ 1233, 1257 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d185.s7.e2" } ] }, { "id": "9074", "type": "Genes/Proteins", "text": [ "thrombin" ], "offsets": [ [ 1218, 1226 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d185.s7.e3" } ] }, { "id": "9075", "type": "Species", "text": [ "rats" ], "offsets": [ [ 1103, 1107 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d185.s7.e4" } ] }, { "id": "9076", "type": "Species", "text": [ "rats" ], "offsets": [ [ 1127, 1131 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d185.s7.e5" } ] }, { "id": "9077", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1281, 1286 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d185.s8.e0" } ] }, { "id": "9078", "type": "Diseases", "text": [ "injured brain" ], "offsets": [ [ 1310, 1323 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d185.s8.e1" } ] } ]

[]

[]

[ { "id": "9079", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d185.s0.e1", "arg2_id": "miRNA-corp.d185.s0.e0", "normalized": [] }, { "id": "9080", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d185.s0.e1", "arg2_id": "miRNA-corp.d185.s0.e2", "normalized": [] }, { "id": "9081", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d185.s0.e1", "arg2_id": "miRNA-corp.d185.s0.e3", "normalized": [] }, { "id": "9082", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d185.s2.e0", "arg2_id": "miRNA-corp.d185.s2.e4", "normalized": [] }, { "id": "9083", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d185.s2.e0", "arg2_id": "miRNA-corp.d185.s2.e5", "normalized": [] }, { "id": "9084", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d185.s2.e1", "arg2_id": "miRNA-corp.d185.s2.e4", "normalized": [] }, { "id": "9085", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d185.s2.e1", "arg2_id": "miRNA-corp.d185.s2.e5", "normalized": [] }, { "id": "9086", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d185.s2.e2", "arg2_id": "miRNA-corp.d185.s2.e4", "normalized": [] }, { "id": "9087", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d185.s2.e2", "arg2_id": "miRNA-corp.d185.s2.e5", "normalized": [] }, { "id": "9088", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d185.s2.e3", "arg2_id": "miRNA-corp.d185.s2.e4", "normalized": [] }, { "id": "9089", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d185.s2.e3", "arg2_id": "miRNA-corp.d185.s2.e5", "normalized": [] }, { "id": "9090", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d185.s3.e3", "arg2_id": "miRNA-corp.d185.s3.e4", "normalized": [] }, { "id": "9091", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d185.s3.e0", "arg2_id": "miRNA-corp.d185.s3.e4", "normalized": [] }, { "id": "9092", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d185.s3.e1", "arg2_id": "miRNA-corp.d185.s3.e4", "normalized": [] }, { "id": "9093", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d185.s3.e2", "arg2_id": "miRNA-corp.d185.s3.e4", "normalized": [] }, { "id": "9094", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d185.s4.e0", "arg2_id": "miRNA-corp.d185.s4.e3", "normalized": [] }, { "id": "9095", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d185.s4.e1", "arg2_id": "miRNA-corp.d185.s4.e3", "normalized": [] }, { "id": "9096", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d185.s8.e0", "arg2_id": "miRNA-corp.d185.s8.e1", "normalized": [] } ]

[ { "id": "9098", "type": "title", "text": [ "A MicroRNA feedback circuit in midbrain dopamine neurons. " ], "offsets": [ [ 0, 59 ] ] }, { "id": "9099", "type": "abstract", "text": [ "MicroRNAs (miRNAs) are evolutionarily conserved, 18- to 25-nucleotide, non-protein coding transcripts that posttranscriptionally regulate gene expression during development. " ], "offsets": [ [ 60, 234 ] ] }, { "id": "9100", "type": "abstract", "text": [ "miRNAs also occur in postmitotic cells, such as neurons in the mammalian central nervous system, but their function is less well characterized. " ], "offsets": [ [ 235, 379 ] ] }, { "id": "9101", "type": "abstract", "text": [ "We investigated the role of miRNAs in mammalian midbrain dopaminergic neurons (DNs). " ], "offsets": [ [ 380, 465 ] ] }, { "id": "9102", "type": "abstract", "text": [ "We identified a miRNA, miR-133b, that is specifically expressed in midbrain DNs and is deficient in midbrain tissue from patients with Parkinson's disease. " ], "offsets": [ [ 466, 622 ] ] }, { "id": "9103", "type": "abstract", "text": [ "miR-133b regulates the maturation and function of midbrain DNs within a negative feedback circuit that includes the paired-like homeodomain transcription factor Pitx3. " ], "offsets": [ [ 623, 791 ] ] } ]

[ { "id": "9104", "type": "Non-Specific_miRNAs", "text": [ "MicroRNA" ], "offsets": [ [ 2, 10 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d186.s0.e0" } ] }, { "id": "9105", "type": "Non-Specific_miRNAs", "text": [ "MicroRNAs" ], "offsets": [ [ 60, 69 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d186.s1.e0" } ] }, { "id": "9106", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 71, 77 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d186.s1.e1" } ] }, { "id": "9107", "type": "Relation_Trigger", "text": [ "regulate gene expression" ], "offsets": [ [ 189, 213 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d186.s1.e2" } ] }, { "id": "9108", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 235, 241 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d186.s2.e0" } ] }, { "id": "9109", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 408, 414 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d186.s3.e0" } ] }, { "id": "9110", "type": "Specific_miRNAs", "text": [ "miR-133b" ], "offsets": [ [ 489, 497 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d186.s4.e0" } ] }, { "id": "9111", "type": "Diseases", "text": [ "Parkinson's disease" ], "offsets": [ [ 601, 620 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d186.s4.e1" } ] }, { "id": "9112", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 482, 487 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d186.s4.e2" } ] }, { "id": "9113", "type": "Relation_Trigger", "text": [ "specifically expressed" ], "offsets": [ [ 507, 529 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d186.s4.e3" } ] }, { "id": "9114", "type": "Species", "text": [ "patients" ], "offsets": [ [ 587, 595 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d186.s4.e4" } ] }, { "id": "9115", "type": "Specific_miRNAs", "text": [ "miR-133b" ], "offsets": [ [ 623, 631 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d186.s5.e0" } ] }, { "id": "9116", "type": "Genes/Proteins", "text": [ "Pitx3" ], "offsets": [ [ 784, 789 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d186.s5.e1" } ] }, { "id": "9117", "type": "Relation_Trigger", "text": [ "regulates" ], "offsets": [ [ 632, 641 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d186.s5.e2" } ] } ]

[]

[]

[ { "id": "9118", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d186.s4.e0", "arg2_id": "miRNA-corp.d186.s4.e1", "normalized": [] }, { "id": "9119", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d186.s4.e2", "arg2_id": "miRNA-corp.d186.s4.e1", "normalized": [] }, { "id": "9120", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d186.s5.e0", "arg2_id": "miRNA-corp.d186.s5.e1", "normalized": [] } ]

[ { "id": "9122", "type": "title", "text": [ "Our results implicate deregulated synthesis of E2F1/DP caused by the miRNA pathway impairment as a key event in LRRK2 pathogenesis and suggest novel miRNA-based therapeutic strategies. " ], "offsets": [ [ 0, 187 ] ] }, { "id": "9123", "type": "abstract", "text": [ "Further, pathogenic LRRK2 promoted the association of phospho-4E-BP1 with hAgo2. " ], "offsets": [ [ 188, 269 ] ] }, { "id": "9124", "type": "abstract", "text": [ "The molecular mechanism of LRRK2 action is not known. " ], "offsets": [ [ 270, 324 ] ] }, { "id": "9125", "type": "abstract", "text": [ "Here we show that LRRK2 interacts with the microRNA (miRNA) pathway to regulate protein synthesis. " ], "offsets": [ [ 325, 424 ] ] }, { "id": "9126", "type": "abstract", "text": [ "Drosophila e2f1 and dp messenger RNAs are translationally repressed by let-7 and miR-184*, respectively. " ], "offsets": [ [ 425, 530 ] ] }, { "id": "9127", "type": "abstract", "text": [ "Pathogenic LRRK2 antagonizes these miRNAs, leading to the overproduction of E2F1/DP, previously implicated in cell cycle and survival control and shown here to be critical for LRRK2 pathogenesis. " ], "offsets": [ [ 531, 727 ] ] }, { "id": "9128", "type": "abstract", "text": [ "Genetic deletion of let-7, antagomir-mediated blockage of let-7 and miR-184* action, transgenic expression of dp target protector, or replacement of endogenous dp with a dp transgene non-responsive to let-7 each had toxic effects similar to those of pathogenic LRRK2. " ], "offsets": [ [ 728, 996 ] ] }, { "id": "9129", "type": "abstract", "text": [ "Conversely, increasing the level of let-7 or miR-184* attenuated pathogenic LRRK2 effects. " ], "offsets": [ [ 997, 1088 ] ] }, { "id": "9130", "type": "abstract", "text": [ "LRRK2 associated with Drosophila Argonaute-1 (dAgo1) or human Argonaute-2 (hAgo2) of the RNA-induced silencing complex (RISC). " ], "offsets": [ [ 1089, 1216 ] ] }, { "id": "9131", "type": "abstract", "text": [ "In aged fly brain, dAgo1 protein level was negatively regulated by LRRK2. " ], "offsets": [ [ 1217, 1291 ] ] }, { "id": "9132", "type": "abstract", "text": [ "Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression. " ], "offsets": [ [ 1292, 1375 ] ] }, { "id": "9133", "type": "abstract", "text": [ "Gain-of-function mutations in leucine-rich repeat kinase 2 (LRRK2) cause familial as well as sporadic Parkinson's disease characterized by age-dependent degeneration of dopaminergic neurons. " ], "offsets": [ [ 1376, 1567 ] ] } ]

[ { "id": "9134", "type": "Genes/Proteins", "text": [ "LRRK2" ], "offsets": [ [ 112, 117 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d187.s0.e0" } ] }, { "id": "9135", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 149, 154 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d187.s0.e1" } ] }, { "id": "9136", "type": "Relation_Trigger", "text": [ "deregulated" ], "offsets": [ [ 22, 33 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d187.s0.e2" } ] }, { "id": "9137", "type": "Relation_Trigger", "text": [ "impairment" ], "offsets": [ [ 83, 93 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d187.s0.e3" } ] }, { "id": "9138", "type": "Genes/Proteins", "text": [ "E2F1" ], "offsets": [ [ 47, 51 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d187.s0.e4" } ] }, { "id": "9139", "type": "Genes/Proteins", "text": [ "DP" ], "offsets": [ [ 52, 54 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d187.s0.e5" } ] }, { "id": "9140", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 69, 74 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d187.s0.e6" } ] }, { "id": "9141", "type": "Genes/Proteins", "text": [ "LRRK2" ], "offsets": [ [ 208, 213 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d187.s1.e0" } ] }, { "id": "9142", "type": "Genes/Proteins", "text": [ "hAgo2" ], "offsets": [ [ 262, 267 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d187.s1.e1" } ] }, { "id": "9143", "type": "Relation_Trigger", "text": [ "association" ], "offsets": [ [ 227, 238 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d187.s1.e2" } ] }, { "id": "9144", "type": "Genes/Proteins", "text": [ "LRRK2" ], "offsets": [ [ 297, 302 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d187.s2.e0" } ] }, { "id": "9145", "type": "Genes/Proteins", "text": [ "LRRK2" ], "offsets": [ [ 343, 348 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d187.s3.e0" } ] }, { "id": "9146", "type": "Relation_Trigger", "text": [ "regulate" ], "offsets": [ [ 396, 404 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d187.s3.e1" } ] }, { "id": "9147", "type": "Non-Specific_miRNAs", "text": [ "microRNA" ], "offsets": [ [ 368, 376 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d187.s3.e2" } ] }, { "id": "9148", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 378, 383 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d187.s3.e3" } ] }, { "id": "9149", "type": "Genes/Proteins", "text": [ "e2f1" ], "offsets": [ [ 436, 440 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d187.s4.e0" } ] }, { "id": "9150", "type": "Specific_miRNAs", "text": [ "let-7" ], "offsets": [ [ 496, 501 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d187.s4.e1" } ] }, { "id": "9151", "type": "Specific_miRNAs", "text": [ "miR-184" ], "offsets": [ [ 506, 513 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d187.s4.e2" } ] }, { "id": "9152", "type": "Relation_Trigger", "text": [ "translationally repressed" ], "offsets": [ [ 467, 492 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d187.s4.e3" } ] }, { "id": "9153", "type": "Genes/Proteins", "text": [ "LRRK2" ], "offsets": [ [ 542, 547 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d187.s5.e0" } ] }, { "id": "9154", "type": "Genes/Proteins", "text": [ "LRRK2" ], "offsets": [ [ 707, 712 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d187.s5.e1" } ] }, { "id": "9155", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 566, 572 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d187.s5.e2" } ] }, { "id": "9156", "type": "Genes/Proteins", "text": [ "E2F1" ], "offsets": [ [ 607, 611 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d187.s5.e3" } ] }, { "id": "9157", "type": "Genes/Proteins", "text": [ "DP" ], "offsets": [ [ 612, 614 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d187.s5.e4" } ] }, { "id": "9158", "type": "Genes/Proteins", "text": [ "LRRK2" ], "offsets": [ [ 989, 994 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d187.s6.e0" } ] }, { "id": "9159", "type": "Specific_miRNAs", "text": [ "let-7" ], "offsets": [ [ 748, 753 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d187.s6.e1" } ] }, { "id": "9160", "type": "Specific_miRNAs", "text": [ "let-7" ], "offsets": [ [ 786, 791 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d187.s6.e2" } ] }, { "id": "9161", "type": "Specific_miRNAs", "text": [ "miR-184" ], "offsets": [ [ 796, 803 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d187.s6.e3" } ] }, { "id": "9162", "type": "Specific_miRNAs", "text": [ "let-7" ], "offsets": [ [ 929, 934 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d187.s6.e4" } ] }, { "id": "9163", "type": "Relation_Trigger", "text": [ "target" ], "offsets": [ [ 841, 847 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d187.s6.e5" } ] }, { "id": "9164", "type": "Genes/Proteins", "text": [ "LRRK2" ], "offsets": [ [ 1073, 1078 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d187.s7.e0" } ] }, { "id": "9165", "type": "Specific_miRNAs", "text": [ "miR-184" ], "offsets": [ [ 1042, 1049 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d187.s7.e1" } ] }, { "id": "9166", "type": "Specific_miRNAs", "text": [ "let-7" ], "offsets": [ [ 1033, 1038 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d187.s7.e2" } ] }, { "id": "9167", "type": "Relation_Trigger", "text": [ "attenuated" ], "offsets": [ [ 1051, 1061 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d187.s7.e3" } ] }, { "id": "9168", "type": "Relation_Trigger", "text": [ "increasing the level" ], "offsets": [ [ 1009, 1029 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d187.s7.e4" } ] }, { "id": "9169", "type": "Genes/Proteins", "text": [ "LRRK2" ], "offsets": [ [ 1089, 1094 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d187.s8.e0" } ] }, { "id": "9170", "type": "Relation_Trigger", "text": [ "associated" ], "offsets": [ [ 1095, 1105 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d187.s8.e1" } ] }, { "id": "9171", "type": "Genes/Proteins", "text": [ "human Argonaute-2" ], "offsets": [ [ 1145, 1162 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d187.s8.e2" } ] }, { "id": "9172", "type": "Genes/Proteins", "text": [ "hAgo2" ], "offsets": [ [ 1164, 1169 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d187.s8.e3" } ] }, { "id": "9173", "type": "Species", "text": [ "human" ], "offsets": [ [ 1145, 1150 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d187.s8.e4" } ] }, { "id": "9174", "type": "Genes/Proteins", "text": [ "LRRK2" ], "offsets": [ [ 1284, 1289 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d187.s9.e0" } ] }, { "id": "9175", "type": "Relation_Trigger", "text": [ "level was negatively regulated" ], "offsets": [ [ 1250, 1280 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d187.s9.e1" } ] }, { "id": "9176", "type": "Genes/Proteins", "text": [ "LRRK2" ], "offsets": [ [ 1303, 1308 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d187.s10.e0" } ] }, { "id": "9177", "type": "Non-Specific_miRNAs", "text": [ "microRNA" ], "offsets": [ [ 1330, 1338 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d187.s10.e1" } ] }, { "id": "9178", "type": "Relation_Trigger", "text": [ "negatively regulates" ], "offsets": [ [ 1309, 1329 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d187.s10.e2" } ] }, { "id": "9179", "type": "Relation_Trigger", "text": [ "regulates microRNA-mediated translational" ], "offsets": [ [ 1320, 1361 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d187.s10.e3" } ] }, { "id": "9180", "type": "Relation_Trigger", "text": [ "translational repression" ], "offsets": [ [ 1348, 1372 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d187.s10.e4" } ] }, { "id": "9181", "type": "Genes/Proteins", "text": [ "leucine-rich repeat kinase 2" ], "offsets": [ [ 1406, 1434 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d187.s11.e0" } ] }, { "id": "9182", "type": "Genes/Proteins", "text": [ "LRRK2" ], "offsets": [ [ 1436, 1441 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d187.s11.e1" } ] }, { "id": "9183", "type": "Diseases", "text": [ "Parkinson's disease" ], "offsets": [ [ 1478, 1497 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d187.s11.e2" } ] } ]

[]

[]

[ { "id": "9184", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d187.s0.e1", "arg2_id": "miRNA-corp.d187.s0.e0", "normalized": [] }, { "id": "9185", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d187.s0.e1", "arg2_id": "miRNA-corp.d187.s0.e4", "normalized": [] }, { "id": "9186", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d187.s0.e1", "arg2_id": "miRNA-corp.d187.s0.e5", "normalized": [] }, { "id": "9187", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d187.s0.e6", "arg2_id": "miRNA-corp.d187.s0.e0", "normalized": [] }, { "id": "9188", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d187.s0.e6", "arg2_id": "miRNA-corp.d187.s0.e4", "normalized": [] }, { "id": "9189", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d187.s0.e6", "arg2_id": "miRNA-corp.d187.s0.e5", "normalized": [] }, { "id": "9190", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d187.s3.e2", "arg2_id": "miRNA-corp.d187.s3.e0", "normalized": [] }, { "id": "9191", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d187.s3.e3", "arg2_id": "miRNA-corp.d187.s3.e0", "normalized": [] }, { "id": "9192", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d187.s4.e1", "arg2_id": "miRNA-corp.d187.s4.e0", "normalized": [] }, { "id": "9193", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d187.s4.e2", "arg2_id": "miRNA-corp.d187.s4.e0", "normalized": [] }, { "id": "9194", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d187.s5.e2", "arg2_id": "miRNA-corp.d187.s5.e1", "normalized": [] }, { "id": "9195", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d187.s5.e2", "arg2_id": "miRNA-corp.d187.s5.e3", "normalized": [] }, { "id": "9196", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d187.s5.e2", "arg2_id": "miRNA-corp.d187.s5.e4", "normalized": [] }, { "id": "9197", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d187.s5.e2", "arg2_id": "miRNA-corp.d187.s5.e0", "normalized": [] }, { "id": "9198", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d187.s6.e1", "arg2_id": "miRNA-corp.d187.s6.e0", "normalized": [] }, { "id": "9199", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d187.s6.e2", "arg2_id": "miRNA-corp.d187.s6.e0", "normalized": [] }, { "id": "9200", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d187.s6.e3", "arg2_id": "miRNA-corp.d187.s6.e0", "normalized": [] }, { "id": "9201", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d187.s6.e4", "arg2_id": "miRNA-corp.d187.s6.e0", "normalized": [] }, { "id": "9202", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d187.s7.e1", "arg2_id": "miRNA-corp.d187.s7.e0", "normalized": [] }, { "id": "9203", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d187.s7.e2", "arg2_id": "miRNA-corp.d187.s7.e0", "normalized": [] }, { "id": "9204", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d187.s10.e1", "arg2_id": "miRNA-corp.d187.s10.e0", "normalized": [] } ]

[ { "id": "9206", "type": "title", "text": [ "The predicted targets of these miRNAs include those with known or suspected roles in oligodendrocyte development and myelination including C11Orf9, CLDN11, MYTL1, MBOP, MPZL2, and DDR1. " ], "offsets": [ [ 0, 186 ] ] }, { "id": "9207", "type": "abstract", "text": [ "CONCLUSIONS/SIGNIFICANCE: We demonstrate miRNA profiles during distinct stages in oligodendroglial differentiation that may provide key markers of OL maturation. " ], "offsets": [ [ 187, 349 ] ] }, { "id": "9208", "type": "abstract", "text": [ "Principal component analysis revealed four main clusters of miRNA expression corresponding to early, mid, and late progenitors, and mature OLs. These results were supported by correlation analyses between adjacent stages. " ], "offsets": [ [ 350, 572 ] ] }, { "id": "9209", "type": "abstract", "text": [ "Interestingly, the highest differentially-expressed miRNAs demonstrated a similar pattern of expression throughout all stages of differentiation, suggesting that they potentially regulate a common target or set of targets in this process. " ], "offsets": [ [ 573, 812 ] ] }, { "id": "9210", "type": "abstract", "text": [ "Our results reveal pronounced trends in miRNA expression and their potential mRNA target interactions that could provide valuable insight into the molecular mechanisms of differentiation. " ], "offsets": [ [ 813, 1003 ] ] }, { "id": "9211", "type": "abstract", "text": [ "A comparison of miRNAs from our cultured OLs and OL progenitors showed significant similarities with published results from equivalent cells found in the rat and mouse central nervous system. " ], "offsets": [ [ 1004, 1196 ] ] }, { "id": "9212", "type": "abstract", "text": [ "MicroRNA expression profiling of oligodendrocyte differentiation from human embryonic stem cells. " ], "offsets": [ [ 1197, 1296 ] ] }, { "id": "9213", "type": "abstract", "text": [ "MicroRNAs (miRNAs) are considered the \"micromanagers\" of gene expression with suggestive roles in cellular differentiation and maintenance. " ], "offsets": [ [ 1297, 1437 ] ] }, { "id": "9214", "type": "abstract", "text": [ "These cells may provide immense therapeutic potential for lost sensory and motor function in demyelinating conditions, such as spinal cord injury, multiple sclerosis, and transverse myelitis. " ], "offsets": [ [ 1438, 1630 ] ] }, { "id": "9215", "type": "abstract", "text": [ "Total RNA was subjected to miRNA profiling and validations preformed using real-time qRT-PCR. " ], "offsets": [ [ 1631, 1725 ] ] }, { "id": "9216", "type": "abstract", "text": [ "Although unique patterns of miRNA expression in various cell lineages have been characterized, this is the first report documenting their expression during oligodendrocyte maturation from human embryonic stem (hES) cells. " ], "offsets": [ [ 1726, 1948 ] ] }, { "id": "9217", "type": "abstract", "text": [ "Here, we performed a global miRNA analysis to reveal and identify characteristic patterns in the multiple stages leading to OL maturation from hES cells including those targeting factors involved in myelin production. " ], "offsets": [ [ 1949, 2167 ] ] } ]

[ { "id": "9218", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 31, 37 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d188.s0.e0" } ] }, { "id": "9219", "type": "Genes/Proteins", "text": [ "C11Orf9" ], "offsets": [ [ 139, 146 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d188.s0.e1" } ] }, { "id": "9220", "type": "Genes/Proteins", "text": [ "CLDN11" ], "offsets": [ [ 148, 154 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d188.s0.e2" } ] }, { "id": "9221", "type": "Genes/Proteins", "text": [ "MPZL2" ], "offsets": [ [ 169, 174 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d188.s0.e3" } ] }, { "id": "9222", "type": "Genes/Proteins", "text": [ "DDR1" ], "offsets": [ [ 180, 184 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d188.s0.e4" } ] }, { "id": "9223", "type": "Relation_Trigger", "text": [ "predicted targets" ], "offsets": [ [ 4, 21 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d188.s0.e5" } ] }, { "id": "9224", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 228, 233 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d188.s1.e0" } ] }, { "id": "9225", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 410, 415 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d188.s2.e0" } ] }, { "id": "9226", "type": "Relation_Trigger", "text": [ "correlation" ], "offsets": [ [ 526, 537 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d188.s2.e1" } ] }, { "id": "9227", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 625, 631 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d188.s3.e0" } ] }, { "id": "9228", "type": "Relation_Trigger", "text": [ "differentially-expressed" ], "offsets": [ [ 600, 624 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d188.s3.e1" } ] }, { "id": "9229", "type": "Relation_Trigger", "text": [ "regulate" ], "offsets": [ [ 752, 760 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d188.s3.e2" } ] }, { "id": "9230", "type": "Relation_Trigger", "text": [ "target" ], "offsets": [ [ 770, 776 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d188.s3.e3" } ] }, { "id": "9231", "type": "Relation_Trigger", "text": [ "targets" ], "offsets": [ [ 787, 794 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d188.s3.e4" } ] }, { "id": "9232", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 853, 858 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d188.s4.e0" } ] }, { "id": "9233", "type": "Relation_Trigger", "text": [ "potential mRNA target" ], "offsets": [ [ 880, 901 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d188.s4.e1" } ] }, { "id": "9234", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1020, 1026 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d188.s5.e0" } ] }, { "id": "9235", "type": "Species", "text": [ "mouse" ], "offsets": [ [ 1166, 1171 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d188.s5.e1" } ] }, { "id": "9236", "type": "Species", "text": [ "rat" ], "offsets": [ [ 1158, 1161 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d188.s5.e2" } ] }, { "id": "9237", "type": "Non-Specific_miRNAs", "text": [ "MicroRNA" ], "offsets": [ [ 1197, 1205 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d188.s6.e0" } ] }, { "id": "9238", "type": "Species", "text": [ "human" ], "offsets": [ [ 1267, 1272 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d188.s6.e1" } ] }, { "id": "9239", "type": "Non-Specific_miRNAs", "text": [ "MicroRNAs" ], "offsets": [ [ 1297, 1306 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d188.s8.e0" } ] }, { "id": "9240", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1308, 1314 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d188.s8.e1" } ] }, { "id": "9241", "type": "Diseases", "text": [ "spinal cord injury" ], "offsets": [ [ 1565, 1583 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d188.s10.e0" } ] }, { "id": "9242", "type": "Diseases", "text": [ "multiple sclerosis" ], "offsets": [ [ 1585, 1603 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d188.s10.e1" } ] }, { "id": "9243", "type": "Diseases", "text": [ "transverse myelitis" ], "offsets": [ [ 1609, 1628 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d188.s10.e2" } ] }, { "id": "9244", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1658, 1663 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d188.s12.e0" } ] }, { "id": "9245", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1754, 1759 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d188.s13.e0" } ] }, { "id": "9246", "type": "Species", "text": [ "human" ], "offsets": [ [ 1914, 1919 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d188.s13.e1" } ] }, { "id": "9247", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1977, 1982 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d188.s14.e0" } ] }, { "id": "9248", "type": "Relation_Trigger", "text": [ "targeting" ], "offsets": [ [ 2118, 2127 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d188.s14.e1" } ] } ]

[]

[]

[ { "id": "9249", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d188.s0.e0", "arg2_id": "miRNA-corp.d188.s0.e1", "normalized": [] }, { "id": "9250", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d188.s0.e0", "arg2_id": "miRNA-corp.d188.s0.e2", "normalized": [] }, { "id": "9251", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d188.s0.e0", "arg2_id": "miRNA-corp.d188.s0.e3", "normalized": [] }, { "id": "9252", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d188.s0.e0", "arg2_id": "miRNA-corp.d188.s0.e4", "normalized": [] } ]

[ { "id": "9254", "type": "title", "text": [ "Recent evidence indicates that miRNAs can function both as tumor suppressors and as oncogenes. " ], "offsets": [ [ 0, 95 ] ] }, { "id": "9255", "type": "abstract", "text": [ "MicroRNAs (miRNAs) are small noncoding regulatory RNAs that reduce stability and/or translation of fully or partially sequence-complementary target mRNAs. " ], "offsets": [ [ 96, 251 ] ] }, { "id": "9256", "type": "abstract", "text": [ "Expression of miR-21, 221, 128a, 128b, 128c, 181a, 181b, 181c was studied using real-time quantitative reverse transcriptase polymerase chain reaction and northern blotting for human astrocytic tumors with different grade of malignancy. " ], "offsets": [ [ 252, 489 ] ] }, { "id": "9257", "type": "abstract", "text": [ "It has been demonstrated that in glioblastoma multiforme miR-21 and 221 are upregulated whereas miR-128 and 181 are downregulated. " ], "offsets": [ [ 490, 621 ] ] }, { "id": "9258", "type": "abstract", "text": [ "miRNA-21 was hyperexpressed in all tumor samples whereas higher levels of miRNA-221 were found in high-grade gliomas. " ], "offsets": [ [ 622, 740 ] ] }, { "id": "9259", "type": "abstract", "text": [ "miR-21 and 221 were overexpressed in glioma samples, whereas miRNA 181b was downregulated compared with normal brain tissue. " ], "offsets": [ [ 741, 866 ] ] }, { "id": "9260", "type": "abstract", "text": [ "The different expression pattern observed in tumors at different stages of malignancy is probably dependent on the cell-specific repertoire of target genes of tumors sharing different molecular pathways activity and suggests miRNAs may have also a place in diagnosis and staging of brain tumors. " ], "offsets": [ [ 867, 1165 ] ] }, { "id": "9261", "type": "abstract", "text": [ "This study is the first analysis of miRNAs in astrocytic tumor at different stages of malignancy. " ], "offsets": [ [ 1166, 1264 ] ] }, { "id": "9262", "type": "abstract", "text": [ "miR-21 and 221 upregulation and miR-181b downregulation in human grade II-IV astrocytic tumors. " ], "offsets": [ [ 1265, 1362 ] ] } ]

[ { "id": "9263", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 31, 37 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d189.s0.e0" } ] }, { "id": "9264", "type": "Relation_Trigger", "text": [ "tumor suppressors" ], "offsets": [ [ 59, 76 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d189.s0.e1" } ] }, { "id": "9265", "type": "Non-Specific_miRNAs", "text": [ "MicroRNAs" ], "offsets": [ [ 96, 105 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d189.s1.e0" } ] }, { "id": "9266", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 107, 113 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d189.s1.e1" } ] }, { "id": "9267", "type": "Relation_Trigger", "text": [ "regulatory" ], "offsets": [ [ 135, 145 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d189.s1.e2" } ] }, { "id": "9268", "type": "Relation_Trigger", "text": [ "target" ], "offsets": [ [ 237, 243 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d189.s1.e3" } ] }, { "id": "9269", "type": "Diseases", "text": [ "astrocytic tumors" ], "offsets": [ [ 435, 452 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d189.s2.e0" } ] }, { "id": "9270", "type": "Specific_miRNAs", "text": [ "miR-21, 221, 128a, 128b, 128c, 181a, 181b, 181c" ], "offsets": [ [ 266, 313 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d189.s2.e1" } ] }, { "id": "9271", "type": "Species", "text": [ "human" ], "offsets": [ [ 429, 434 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d189.s2.e2" } ] }, { "id": "9272", "type": "Diseases", "text": [ "glioblastoma" ], "offsets": [ [ 523, 535 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d189.s3.e0" } ] }, { "id": "9273", "type": "Specific_miRNAs", "text": [ "miR-21 and 221" ], "offsets": [ [ 547, 561 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d189.s3.e1" } ] }, { "id": "9274", "type": "Specific_miRNAs", "text": [ "miR-128 and 181" ], "offsets": [ [ 586, 601 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d189.s3.e2" } ] }, { "id": "9275", "type": "Relation_Trigger", "text": [ "upregulated" ], "offsets": [ [ 566, 577 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d189.s3.e3" } ] }, { "id": "9276", "type": "Relation_Trigger", "text": [ "downregulated" ], "offsets": [ [ 606, 619 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d189.s3.e4" } ] }, { "id": "9277", "type": "Specific_miRNAs", "text": [ "miRNA-21" ], "offsets": [ [ 622, 630 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d189.s4.e0" } ] }, { "id": "9278", "type": "Specific_miRNAs", "text": [ "miRNA-221" ], "offsets": [ [ 696, 705 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d189.s4.e1" } ] }, { "id": "9279", "type": "Relation_Trigger", "text": [ "hyperexpressed" ], "offsets": [ [ 635, 649 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d189.s4.e2" } ] }, { "id": "9280", "type": "Relation_Trigger", "text": [ "higher levels" ], "offsets": [ [ 679, 692 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d189.s4.e3" } ] }, { "id": "9281", "type": "Diseases", "text": [ "high-grade gliomas" ], "offsets": [ [ 720, 738 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d189.s4.e4" } ] }, { "id": "9282", "type": "Diseases", "text": [ "tumor" ], "offsets": [ [ 657, 662 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d189.s4.e5" } ] }, { "id": "9283", "type": "Specific_miRNAs", "text": [ "miR-21 and 221" ], "offsets": [ [ 741, 755 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d189.s5.e0" } ] }, { "id": "9284", "type": "Specific_miRNAs", "text": [ "miRNA 181b" ], "offsets": [ [ 802, 812 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d189.s5.e1" } ] }, { "id": "9285", "type": "Diseases", "text": [ "glioma" ], "offsets": [ [ 778, 784 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d189.s5.e2" } ] }, { "id": "9286", "type": "Relation_Trigger", "text": [ "overexpressed" ], "offsets": [ [ 761, 774 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d189.s5.e3" } ] }, { "id": "9287", "type": "Relation_Trigger", "text": [ "downregulated" ], "offsets": [ [ 817, 830 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d189.s5.e4" } ] }, { "id": "9288", "type": "Diseases", "text": [ "brain tumors" ], "offsets": [ [ 1149, 1161 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d189.s6.e0" } ] }, { "id": "9289", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1092, 1098 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d189.s6.e1" } ] }, { "id": "9290", "type": "Relation_Trigger", "text": [ "target" ], "offsets": [ [ 1010, 1016 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d189.s6.e2" } ] }, { "id": "9291", "type": "Diseases", "text": [ "tumors" ], "offsets": [ [ 912, 918 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d189.s6.e3" } ] }, { "id": "9292", "type": "Diseases", "text": [ "tumors" ], "offsets": [ [ 1026, 1032 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d189.s6.e4" } ] }, { "id": "9293", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 1202, 1208 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d189.s7.e0" } ] }, { "id": "9294", "type": "Diseases", "text": [ "astrocytic tumor" ], "offsets": [ [ 1212, 1228 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d189.s7.e1" } ] }, { "id": "9295", "type": "Specific_miRNAs", "text": [ "miR-21 and 221" ], "offsets": [ [ 1265, 1279 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d189.s8.e0" } ] }, { "id": "9296", "type": "Specific_miRNAs", "text": [ "miR-181b" ], "offsets": [ [ 1297, 1305 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d189.s8.e1" } ] }, { "id": "9297", "type": "Relation_Trigger", "text": [ "upregulation" ], "offsets": [ [ 1280, 1292 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d189.s8.e2" } ] }, { "id": "9298", "type": "Relation_Trigger", "text": [ "downregulation" ], "offsets": [ [ 1306, 1320 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d189.s8.e3" } ] }, { "id": "9299", "type": "Diseases", "text": [ "grade II-IV astrocytic tumors" ], "offsets": [ [ 1330, 1359 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d189.s8.e4" } ] }, { "id": "9300", "type": "Species", "text": [ "human" ], "offsets": [ [ 1324, 1329 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d189.s8.e5" } ] } ]

[]

[]

[ { "id": "9301", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d189.s2.e1", "arg2_id": "miRNA-corp.d189.s2.e0", "normalized": [] }, { "id": "9302", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d189.s3.e1", "arg2_id": "miRNA-corp.d189.s3.e0", "normalized": [] }, { "id": "9303", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d189.s3.e2", "arg2_id": "miRNA-corp.d189.s3.e0", "normalized": [] }, { "id": "9304", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d189.s4.e0", "arg2_id": "miRNA-corp.d189.s4.e4", "normalized": [] }, { "id": "9305", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d189.s4.e0", "arg2_id": "miRNA-corp.d189.s4.e5", "normalized": [] }, { "id": "9306", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d189.s4.e1", "arg2_id": "miRNA-corp.d189.s4.e4", "normalized": [] }, { "id": "9307", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d189.s4.e1", "arg2_id": "miRNA-corp.d189.s4.e5", "normalized": [] }, { "id": "9308", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d189.s5.e0", "arg2_id": "miRNA-corp.d189.s5.e2", "normalized": [] }, { "id": "9309", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d189.s5.e1", "arg2_id": "miRNA-corp.d189.s5.e2", "normalized": [] }, { "id": "9310", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d189.s6.e1", "arg2_id": "miRNA-corp.d189.s6.e0", "normalized": [] }, { "id": "9311", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d189.s6.e1", "arg2_id": "miRNA-corp.d189.s6.e3", "normalized": [] }, { "id": "9312", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d189.s6.e1", "arg2_id": "miRNA-corp.d189.s6.e4", "normalized": [] }, { "id": "9313", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d189.s7.e0", "arg2_id": "miRNA-corp.d189.s7.e1", "normalized": [] }, { "id": "9314", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d189.s8.e0", "arg2_id": "miRNA-corp.d189.s8.e4", "normalized": [] }, { "id": "9315", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d189.s8.e1", "arg2_id": "miRNA-corp.d189.s8.e4", "normalized": [] } ]

[ { "id": "9317", "type": "title", "text": [ "Not surprisingly, deregulation of REST and ncRNAs are both implicated in the molecular pathophysiology underlying diverse disorders that range from brain cancer and stroke to neurodevelopmental and neurodegenerative diseases. " ], "offsets": [ [ 0, 226 ] ] }, { "id": "9318", "type": "abstract", "text": [ "REST and its primary cofactor, CoREST, dynamically recruit highly malleable macromolecular complexes to widely distributed genomic regulatory sequences, including the repressor element-1/neuron restrictive silencer element (RE1/NRSE). " ], "offsets": [ [ 227, 462 ] ] }, { "id": "9319", "type": "abstract", "text": [ "Through epigenetic mechanisms, such as site-specific targeting and higher-order chromatin remodeling, REST and CoREST can mediate cell type- and developmental stage-specific gene repression, gene activation, and long-term gene silencing for protein-coding genes and for several classes of ncRNAs (e.g. microRNAs [miRNAs] and long ncRNAs). " ], "offsets": [ [ 463, 802 ] ] }, { "id": "9320", "type": "abstract", "text": [ "In turn, these ncRNAs have similarly been implicated in the regulation of chromatin architecture and dynamics, transcription, post-transcriptional processing, and RNA editing and trafficking. " ], "offsets": [ [ 803, 995 ] ] }, { "id": "9321", "type": "abstract", "text": [ "In addition, REST and CoREST expression and function are tightly regulated by context-specific transcriptional and post-transcriptional mechanisms including bidirectional feedback loops with various ncRNAs. " ], "offsets": [ [ 996, 1203 ] ] }, { "id": "9322", "type": "abstract", "text": [ "Regulation of non-coding RNA networks in the nervous system--what's the REST of the story? " ], "offsets": [ [ 1204, 1296 ] ] }, { "id": "9323", "type": "abstract", "text": [ "The repressor element-1 silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) and non-coding RNAs (ncRNAs) are emerging as key regulators that seem to orchestrate almost every aspect of nervous system development, homeostasis, and plasticity. " ], "offsets": [ [ 1297, 1565 ] ] } ]

[ { "id": "9324", "type": "Genes/Proteins", "text": [ "REST" ], "offsets": [ [ 34, 38 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d190.s0.e0" } ] }, { "id": "9325", "type": "Relation_Trigger", "text": [ "deregulation" ], "offsets": [ [ 18, 30 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d190.s0.e1" } ] }, { "id": "9326", "type": "Diseases", "text": [ "brain cancer" ], "offsets": [ [ 148, 160 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d190.s0.e2" } ] }, { "id": "9327", "type": "Diseases", "text": [ "stroke" ], "offsets": [ [ 165, 171 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d190.s0.e3" } ] }, { "id": "9328", "type": "Diseases", "text": [ "neurodegenerative diseases" ], "offsets": [ [ 198, 224 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d190.s0.e4" } ] }, { "id": "9329", "type": "Genes/Proteins", "text": [ "REST" ], "offsets": [ [ 227, 231 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d190.s2.e0" } ] }, { "id": "9330", "type": "Genes/Proteins", "text": [ "CoREST" ], "offsets": [ [ 258, 264 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d190.s2.e1" } ] }, { "id": "9331", "type": "Relation_Trigger", "text": [ "regulatory" ], "offsets": [ [ 358, 368 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d190.s2.e2" } ] }, { "id": "9332", "type": "Relation_Trigger", "text": [ "repressor" ], "offsets": [ [ 394, 403 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d190.s2.e3" } ] }, { "id": "9333", "type": "Non-Specific_miRNAs", "text": [ "microRNAs" ], "offsets": [ [ 765, 774 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d190.s3.e0" } ] }, { "id": "9334", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 776, 782 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d190.s3.e1" } ] }, { "id": "9335", "type": "Genes/Proteins", "text": [ "REST" ], "offsets": [ [ 565, 569 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d190.s3.e2" } ] }, { "id": "9336", "type": "Genes/Proteins", "text": [ "CoREST" ], "offsets": [ [ 574, 580 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d190.s3.e3" } ] }, { "id": "9337", "type": "Relation_Trigger", "text": [ "targeting" ], "offsets": [ [ 516, 525 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d190.s3.e4" } ] }, { "id": "9338", "type": "Relation_Trigger", "text": [ "repression" ], "offsets": [ [ 642, 652 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d190.s3.e5" } ] }, { "id": "9339", "type": "Relation_Trigger", "text": [ "activation" ], "offsets": [ [ 659, 669 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d190.s3.e6" } ] }, { "id": "9340", "type": "Relation_Trigger", "text": [ "regulation" ], "offsets": [ [ 863, 873 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d190.s4.e0" } ] }, { "id": "9341", "type": "Genes/Proteins", "text": [ "REST" ], "offsets": [ [ 1009, 1013 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d190.s5.e0" } ] }, { "id": "9342", "type": "Genes/Proteins", "text": [ "CoREST" ], "offsets": [ [ 1018, 1024 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d190.s5.e1" } ] }, { "id": "9343", "type": "Relation_Trigger", "text": [ "regulated" ], "offsets": [ [ 1061, 1070 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d190.s5.e2" } ] }, { "id": "9344", "type": "Relation_Trigger", "text": [ "Regulation" ], "offsets": [ [ 1204, 1214 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d190.s6.e0" } ] }, { "id": "9345", "type": "Genes/Proteins", "text": [ "repressor element-1 silencing transcription factor" ], "offsets": [ [ 1301, 1351 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d190.s7.e0" } ] }, { "id": "9346", "type": "Genes/Proteins", "text": [ "neuron-restrictive silencing factor" ], "offsets": [ [ 1352, 1387 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d190.s7.e1" } ] }, { "id": "9347", "type": "Genes/Proteins", "text": [ "REST" ], "offsets": [ [ 1389, 1393 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d190.s7.e2" } ] }, { "id": "9348", "type": "Genes/Proteins", "text": [ "NRSF" ], "offsets": [ [ 1394, 1398 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d190.s7.e3" } ] }, { "id": "9349", "type": "Relation_Trigger", "text": [ "regulators" ], "offsets": [ [ 1449, 1459 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d190.s7.e4" } ] } ]

[]

[]

[ { "id": "9350", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d190.s3.e0", "arg2_id": "miRNA-corp.d190.s3.e2", "normalized": [] }, { "id": "9351", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d190.s3.e0", "arg2_id": "miRNA-corp.d190.s3.e3", "normalized": [] }, { "id": "9352", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d190.s3.e1", "arg2_id": "miRNA-corp.d190.s3.e2", "normalized": [] }, { "id": "9353", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d190.s3.e1", "arg2_id": "miRNA-corp.d190.s3.e3", "normalized": [] } ]

[ { "id": "9355", "type": "title", "text": [ "The miRNAs in a whole cell regulate greater than 30% of all protein-coding genes. " ], "offsets": [ [ 0, 82 ] ] }, { "id": "9356", "type": "abstract", "text": [ "MicroRNAs (miRNAs) are a group of small noncoding RNAs that regulate translational repression of multiple target mRNAs. " ], "offsets": [ [ 83, 203 ] ] }, { "id": "9357", "type": "abstract", "text": [ "MicroRNAs and their therapeutic potential for human diseases: aberrant microRNA expression in Alzheimer's disease brains. " ], "offsets": [ [ 204, 327 ] ] }, { "id": "9358", "type": "abstract", "text": [ "This review will briefly summarize recent studies that focus attention on aberrant miRNA expression in Alzheimer's disease brains. " ], "offsets": [ [ 328, 461 ] ] }, { "id": "9359", "type": "abstract", "text": [ "However, at present, the pathological implications of deregulated miRNA expression in neurodegenerative diseases remain largely unknown. " ], "offsets": [ [ 462, 599 ] ] }, { "id": "9360", "type": "abstract", "text": [ "The vast majority of presently identified miRNAs are expressed in the brain in a spatially and temporally controlled manner. " ], "offsets": [ [ 600, 725 ] ] } ]

[ { "id": "9361", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 4, 10 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d191.s0.e0" } ] }, { "id": "9362", "type": "Relation_Trigger", "text": [ "regulate" ], "offsets": [ [ 27, 35 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d191.s0.e1" } ] }, { "id": "9363", "type": "Non-Specific_miRNAs", "text": [ "MicroRNAs" ], "offsets": [ [ 83, 92 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d191.s1.e0" } ] }, { "id": "9364", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 94, 100 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d191.s1.e1" } ] }, { "id": "9365", "type": "Relation_Trigger", "text": [ "translational repression" ], "offsets": [ [ 152, 176 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d191.s1.e2" } ] }, { "id": "9366", "type": "Relation_Trigger", "text": [ "regulate" ], "offsets": [ [ 143, 151 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d191.s1.e3" } ] }, { "id": "9367", "type": "Relation_Trigger", "text": [ "target" ], "offsets": [ [ 189, 195 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d191.s1.e4" } ] }, { "id": "9368", "type": "Non-Specific_miRNAs", "text": [ "MicroRNAs" ], "offsets": [ [ 204, 213 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d191.s2.e0" } ] }, { "id": "9369", "type": "Non-Specific_miRNAs", "text": [ "microRNA" ], "offsets": [ [ 275, 283 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d191.s2.e1" } ] }, { "id": "9370", "type": "Diseases", "text": [ "Alzheimer's disease" ], "offsets": [ [ 298, 317 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d191.s2.e2" } ] }, { "id": "9371", "type": "Relation_Trigger", "text": [ "aberrant microRNA expression" ], "offsets": [ [ 266, 294 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d191.s2.e3" } ] }, { "id": "9372", "type": "Species", "text": [ "human" ], "offsets": [ [ 250, 255 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d191.s2.e4" } ] }, { "id": "9373", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 411, 416 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d191.s3.e0" } ] }, { "id": "9374", "type": "Diseases", "text": [ "Alzheimer's disease" ], "offsets": [ [ 431, 450 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d191.s3.e1" } ] }, { "id": "9375", "type": "Relation_Trigger", "text": [ "aberrant miRNA expression" ], "offsets": [ [ 402, 427 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d191.s3.e2" } ] }, { "id": "9376", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 528, 533 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d191.s4.e0" } ] }, { "id": "9377", "type": "Relation_Trigger", "text": [ "deregulated miRNA expression" ], "offsets": [ [ 516, 544 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d191.s4.e1" } ] }, { "id": "9378", "type": "Diseases", "text": [ "neurodegenerative diseases" ], "offsets": [ [ 548, 574 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d191.s4.e2" } ] }, { "id": "9379", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 642, 648 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d191.s6.e0" } ] } ]

[]

[]

[ { "id": "9380", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d191.s2.e0", "arg2_id": "miRNA-corp.d191.s2.e2", "normalized": [] }, { "id": "9381", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d191.s2.e1", "arg2_id": "miRNA-corp.d191.s2.e2", "normalized": [] }, { "id": "9382", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d191.s3.e0", "arg2_id": "miRNA-corp.d191.s3.e1", "normalized": [] }, { "id": "9383", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d191.s4.e0", "arg2_id": "miRNA-corp.d191.s4.e2", "normalized": [] } ]

[ { "id": "9385", "type": "title", "text": [ "Our studies suggest that ban functions downstream of toxicity of the SCA3 protein, to prevent degeneration. " ], "offsets": [ [ 0, 108 ] ] }, { "id": "9386", "type": "abstract", "text": [ "These findings indicate that miRNA pathways dramatically modulate polyQ- and tau-induced neurodegeneration, providing the foundation for new insight into therapeutics. " ], "offsets": [ [ 109, 279 ] ] }, { "id": "9387", "type": "abstract", "text": [ "To address whether miRNA pathways play a role in neurodegeneration, we tested whether genes critical for miRNA processing modulated toxicity induced by the spinocerebellar ataxia type 3 (SCA3) protein. " ], "offsets": [ [ 280, 482 ] ] }, { "id": "9388", "type": "abstract", "text": [ "MicroRNAs (miRNAs) have been shown to modulate programmed cell death during development. " ], "offsets": [ [ 483, 572 ] ] }, { "id": "9389", "type": "abstract", "text": [ "In parallel genetic screens, we identified the miRNA bantam (ban) as a potent modulator of both polyQ and tau toxicity in flies. " ], "offsets": [ [ 573, 702 ] ] }, { "id": "9390", "type": "abstract", "text": [ "These studies revealed a striking enhancement of polyQ toxicity upon reduction of miRNA processing in Drosophila and human cells. " ], "offsets": [ [ 703, 833 ] ] }, { "id": "9391", "type": "abstract", "text": [ "MicroRNA pathways modulate polyglutamine-induced neurodegeneration. " ], "offsets": [ [ 834, 903 ] ] }, { "id": "9392", "type": "abstract", "text": [ "Nine human neurodegenerative diseases are due to expansion of a CAG repeat- encoding glutamine within the open reading frame of the respective genes. " ], "offsets": [ [ 904, 1054 ] ] } ]

[ { "id": "9393", "type": "Genes/Proteins", "text": [ "SCA3" ], "offsets": [ [ 69, 73 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d192.s0.e0" } ] }, { "id": "9394", "type": "Relation_Trigger", "text": [ "modulate" ], "offsets": [ [ 166, 174 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d192.s1.e0" } ] }, { "id": "9395", "type": "Genes/Proteins", "text": [ "tau" ], "offsets": [ [ 186, 189 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d192.s1.e1" } ] }, { "id": "9396", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 138, 143 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d192.s1.e2" } ] }, { "id": "9397", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 385, 390 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d192.s2.e0" } ] }, { "id": "9398", "type": "Relation_Trigger", "text": [ "modulated" ], "offsets": [ [ 402, 411 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d192.s2.e1" } ] }, { "id": "9399", "type": "Genes/Proteins", "text": [ "SCA3" ], "offsets": [ [ 467, 471 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d192.s2.e2" } ] }, { "id": "9400", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 299, 304 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d192.s2.e3" } ] }, { "id": "9401", "type": "Genes/Proteins", "text": [ "spinocerebellar ataxia type 3 (SCA3) protein" ], "offsets": [ [ 436, 480 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d192.s2.e4" } ] }, { "id": "9402", "type": "Non-Specific_miRNAs", "text": [ "MicroRNAs" ], "offsets": [ [ 483, 492 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d192.s3.e0" } ] }, { "id": "9403", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 494, 500 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d192.s3.e1" } ] }, { "id": "9404", "type": "Relation_Trigger", "text": [ "modulate" ], "offsets": [ [ 521, 529 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d192.s3.e2" } ] }, { "id": "9405", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 620, 625 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d192.s4.e0" } ] }, { "id": "9406", "type": "Relation_Trigger", "text": [ "modulator" ], "offsets": [ [ 651, 660 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d192.s4.e1" } ] }, { "id": "9407", "type": "Genes/Proteins", "text": [ "tau" ], "offsets": [ [ 679, 682 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d192.s4.e2" } ] }, { "id": "9408", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 785, 790 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d192.s5.e0" } ] }, { "id": "9409", "type": "Species", "text": [ "human" ], "offsets": [ [ 820, 825 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d192.s5.e1" } ] }, { "id": "9410", "type": "Relation_Trigger", "text": [ "modulate" ], "offsets": [ [ 852, 860 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d192.s6.e0" } ] }, { "id": "9411", "type": "Non-Specific_miRNAs", "text": [ "MicroRNA" ], "offsets": [ [ 834, 842 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d192.s6.e1" } ] }, { "id": "9412", "type": "Diseases", "text": [ "neurodegenerative diseases" ], "offsets": [ [ 915, 941 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d192.s8.e0" } ] }, { "id": "9413", "type": "Species", "text": [ "human" ], "offsets": [ [ 909, 914 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d192.s8.e1" } ] } ]

[]

[]

[ { "id": "9414", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d192.s1.e2", "arg2_id": "miRNA-corp.d192.s1.e1", "normalized": [] }, { "id": "9415", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d192.s2.e3", "arg2_id": "miRNA-corp.d192.s2.e2", "normalized": [] }, { "id": "9416", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d192.s2.e3", "arg2_id": "miRNA-corp.d192.s2.e4", "normalized": [] }, { "id": "9417", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d192.s2.e0", "arg2_id": "miRNA-corp.d192.s2.e2", "normalized": [] }, { "id": "9418", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d192.s2.e0", "arg2_id": "miRNA-corp.d192.s2.e4", "normalized": [] }, { "id": "9419", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d192.s4.e0", "arg2_id": "miRNA-corp.d192.s4.e2", "normalized": [] } ]

[ { "id": "9421", "type": "title", "text": [ "Western blot was applied to analyze the expression of eiF4E3 in both experimental group and control group. " ], "offsets": [ [ 0, 107 ] ] }, { "id": "9422", "type": "abstract", "text": [ "RESULT: EiF4E3 was the most likely potential targeting protein of microRNA-338. " ], "offsets": [ [ 108, 188 ] ] }, { "id": "9423", "type": "abstract", "text": [ "The potential targeting proteins were then selected according to their secondary structures using RNA structure 4.6 software and their involvement in cerebral ischemia and reperfusion injury was studied. " ], "offsets": [ [ 189, 393 ] ] }, { "id": "9424", "type": "abstract", "text": [ "Dual-luciferase reporter assay was used to testify whether microRNA-338 can recognize the 3'UTR of target protein. " ], "offsets": [ [ 394, 509 ] ] }, { "id": "9425", "type": "abstract", "text": [ "OBJECTIVE: To analyze the interaction between the microRNA-338 and its targeting proteins during the cerebral ischemia and reperfusion injury. " ], "offsets": [ [ 510, 653 ] ] }, { "id": "9426", "type": "abstract", "text": [ "METHODS: TargetScan was used to predict the targets of microRNA-338. " ], "offsets": [ [ 654, 723 ] ] }, { "id": "9427", "type": "abstract", "text": [ "[Interaction of microRNA-338 and its potential targeting protein eiF4E3]. " ], "offsets": [ [ 724, 799 ] ] }, { "id": "9428", "type": "abstract", "text": [ "However, there was no significant difference in the expression of eiF4E3 between these two groups. " ], "offsets": [ [ 800, 899 ] ] }, { "id": "9429", "type": "abstract", "text": [ "The secondary structure of local region of eiF4E3 recognizing microRNA-338 was conservative. " ], "offsets": [ [ 900, 993 ] ] }, { "id": "9430", "type": "abstract", "text": [ "CONCLUSION: MicroRNA-338 can recognize the 3'UTR of eiF4E3 while it has no significant effect on the expression of eiF4E3. " ], "offsets": [ [ 994, 1117 ] ] }, { "id": "9431", "type": "abstract", "text": [ "The post-target-recognizing regulation for miRNA do exist and this mechanism is possibly related to the tertiary structure of target mRNA. " ], "offsets": [ [ 1118, 1259 ] ] } ]

[ { "id": "9432", "type": "Genes/Proteins", "text": [ "eiF4E3" ], "offsets": [ [ 54, 60 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d193.s0.e0" } ] }, { "id": "9433", "type": "Relation_Trigger", "text": [ "potential targeting protein" ], "offsets": [ [ 143, 170 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d193.s1.e0" } ] }, { "id": "9434", "type": "Specific_miRNAs", "text": [ "microRNA-338" ], "offsets": [ [ 174, 186 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d193.s1.e1" } ] }, { "id": "9435", "type": "Genes/Proteins", "text": [ "EiF4E3" ], "offsets": [ [ 116, 122 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d193.s1.e2" } ] }, { "id": "9436", "type": "Diseases", "text": [ "cerebral ischemia" ], "offsets": [ [ 339, 356 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d193.s2.e0" } ] }, { "id": "9437", "type": "Diseases", "text": [ "reperfusion injury" ], "offsets": [ [ 361, 379 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d193.s2.e1" } ] }, { "id": "9438", "type": "Relation_Trigger", "text": [ "targeting" ], "offsets": [ [ 203, 212 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d193.s2.e2" } ] }, { "id": "9439", "type": "Specific_miRNAs", "text": [ "microRNA-338" ], "offsets": [ [ 453, 465 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d193.s3.e0" } ] }, { "id": "9440", "type": "Relation_Trigger", "text": [ "recognize the 3'UTR" ], "offsets": [ [ 470, 489 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d193.s3.e1" } ] }, { "id": "9441", "type": "Relation_Trigger", "text": [ "target" ], "offsets": [ [ 493, 499 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d193.s3.e2" } ] }, { "id": "9442", "type": "Specific_miRNAs", "text": [ "microRNA-338" ], "offsets": [ [ 560, 572 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d193.s4.e0" } ] }, { "id": "9443", "type": "Diseases", "text": [ "cerebral ischemia" ], "offsets": [ [ 611, 628 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d193.s4.e1" } ] }, { "id": "9444", "type": "Diseases", "text": [ "reperfusion injury" ], "offsets": [ [ 633, 651 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d193.s4.e2" } ] }, { "id": "9445", "type": "Relation_Trigger", "text": [ "targeting" ], "offsets": [ [ 581, 590 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d193.s4.e3" } ] }, { "id": "9446", "type": "Specific_miRNAs", "text": [ "microRNA-338" ], "offsets": [ [ 709, 721 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d193.s5.e0" } ] }, { "id": "9447", "type": "Relation_Trigger", "text": [ "targets" ], "offsets": [ [ 698, 705 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d193.s5.e1" } ] }, { "id": "9448", "type": "Relation_Trigger", "text": [ "potential targeting protein" ], "offsets": [ [ 761, 788 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d193.s6.e0" } ] }, { "id": "9449", "type": "Specific_miRNAs", "text": [ "microRNA-338" ], "offsets": [ [ 740, 752 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d193.s6.e1" } ] }, { "id": "9450", "type": "Genes/Proteins", "text": [ "eiF4E3" ], "offsets": [ [ 789, 795 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d193.s6.e2" } ] }, { "id": "9451", "type": "Genes/Proteins", "text": [ "eiF4E3" ], "offsets": [ [ 866, 872 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d193.s7.e0" } ] }, { "id": "9452", "type": "Specific_miRNAs", "text": [ "microRNA-338" ], "offsets": [ [ 962, 974 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d193.s8.e0" } ] }, { "id": "9453", "type": "Genes/Proteins", "text": [ "eiF4E3" ], "offsets": [ [ 943, 949 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d193.s8.e1" } ] }, { "id": "9454", "type": "Relation_Trigger", "text": [ "recognize the 3'UTR" ], "offsets": [ [ 1023, 1042 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d193.s10.e0" } ] }, { "id": "9455", "type": "Specific_miRNAs", "text": [ "MicroRNA-338" ], "offsets": [ [ 1006, 1018 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d193.s10.e1" } ] }, { "id": "9456", "type": "Genes/Proteins", "text": [ "eiF4E3" ], "offsets": [ [ 1046, 1052 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d193.s10.e2" } ] }, { "id": "9457", "type": "Genes/Proteins", "text": [ "eiF4E3" ], "offsets": [ [ 1109, 1115 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d193.s10.e3" } ] }, { "id": "9458", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 1161, 1166 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d193.s11.e0" } ] }, { "id": "9459", "type": "Relation_Trigger", "text": [ "regulation" ], "offsets": [ [ 1146, 1156 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d193.s11.e1" } ] }, { "id": "9460", "type": "Relation_Trigger", "text": [ "target" ], "offsets": [ [ 1244, 1250 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d193.s11.e2" } ] } ]

[]

[]

[ { "id": "9461", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d193.s1.e1", "arg2_id": "miRNA-corp.d193.s1.e2", "normalized": [] }, { "id": "9462", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d193.s4.e0", "arg2_id": "miRNA-corp.d193.s4.e1", "normalized": [] }, { "id": "9463", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d193.s4.e0", "arg2_id": "miRNA-corp.d193.s4.e2", "normalized": [] }, { "id": "9464", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d193.s6.e1", "arg2_id": "miRNA-corp.d193.s6.e2", "normalized": [] }, { "id": "9465", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d193.s8.e0", "arg2_id": "miRNA-corp.d193.s8.e1", "normalized": [] }, { "id": "9466", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d193.s10.e1", "arg2_id": "miRNA-corp.d193.s10.e2", "normalized": [] }, { "id": "9467", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d193.s10.e1", "arg2_id": "miRNA-corp.d193.s10.e3", "normalized": [] } ]

[ { "id": "9469", "type": "title", "text": [ "We conclude that lentiviral expression of anti-ADK miRNA constitutes a versatile tool to generate therapeutically effective adenosine releasing hMSCs, thus representing a model system to generate patient identical autologous adult stem cell grafts. " ], "offsets": [ [ 0, 251 ] ] }, { "id": "9470", "type": "abstract", "text": [ "While mice with control implants expressing a scrambled miRNA sequence or sham treated control animals were characterized by KA-induced status epilepticus and subsequent CA3 neuronal cell loss, animals with therapeutic ADK knockdown implants displayed a 35% reduction in seizure duration and 65% reduction in CA3 neuronal cell loss, when analyzed 24 h after KA-injection. " ], "offsets": [ [ 252, 624 ] ] }, { "id": "9471", "type": "abstract", "text": [ "hMSCs with a knockdown of ADK or cells expressing a scrambled control sequence were transplanted into hippocampi of mice 1 week prior to the intraamygdaloid injection of kainic acid (KA). " ], "offsets": [ [ 625, 813 ] ] }, { "id": "9472", "type": "abstract", "text": [ "Following lentiviral transduction of hMSCs with anti-ADK miRNA expression cassettes we demonstrate up to 80% downregulation of ADK and a concentration of 8.5 ng adenosine per ml of medium after incubating 10(5) cells for 8 h. " ], "offsets": [ [ 814, 1040 ] ] }, { "id": "9473", "type": "abstract", "text": [ "Here we describe a novel approach based on lentiviral RNAi mediated downregulation of adenosine kinase (ADK), the major adenosine-removing enzyme, in human mesenchymal stem cells (hMSCs), which would be compatible with autologous cell grafting in patients. " ], "offsets": [ [ 1041, 1298 ] ] }, { "id": "9474", "type": "abstract", "text": [ "Autologous patient-derived adenosine-releasing cell implants would constitute a major therapeutic advance to avoid both xenotransplantation and immunosuppression. " ], "offsets": [ [ 1299, 1462 ] ] }, { "id": "9475", "type": "abstract", "text": [ "Cell therapies based on focal delivery of the inhibitory neuromodulator adenosine were previously shown to provide potent seizure suppression in animal models of epilepsy. " ], "offsets": [ [ 1463, 1635 ] ] }, { "id": "9476", "type": "abstract", "text": [ "Lentiviral RNAi-induced downregulation of adenosine kinase in human mesenchymal stem cell grafts: a novel perspective for seizure control. " ], "offsets": [ [ 1636, 1776 ] ] } ]

[ { "id": "9477", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 51, 56 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d194.s0.e0" } ] }, { "id": "9478", "type": "Species", "text": [ "patient" ], "offsets": [ [ 196, 203 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d194.s0.e1" } ] }, { "id": "9479", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 308, 313 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d194.s1.e0" } ] }, { "id": "9480", "type": "Diseases", "text": [ "status epilepticus" ], "offsets": [ [ 388, 406 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d194.s1.e1" } ] }, { "id": "9481", "type": "Genes/Proteins", "text": [ "ADK" ], "offsets": [ [ 471, 474 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d194.s1.e2" } ] }, { "id": "9482", "type": "Diseases", "text": [ "seizure" ], "offsets": [ [ 523, 530 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d194.s1.e3" } ] }, { "id": "9483", "type": "Species", "text": [ "mice" ], "offsets": [ [ 258, 262 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d194.s1.e4" } ] }, { "id": "9484", "type": "Genes/Proteins", "text": [ "ADK" ], "offsets": [ [ 651, 654 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d194.s2.e0" } ] }, { "id": "9485", "type": "Species", "text": [ "mice" ], "offsets": [ [ 741, 745 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d194.s2.e1" } ] }, { "id": "9486", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 871, 876 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d194.s3.e0" } ] }, { "id": "9487", "type": "Genes/Proteins", "text": [ "ADK" ], "offsets": [ [ 941, 944 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d194.s3.e1" } ] }, { "id": "9488", "type": "Relation_Trigger", "text": [ "downregulation" ], "offsets": [ [ 923, 937 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d194.s3.e2" } ] }, { "id": "9489", "type": "Relation_Trigger", "text": [ "downregulation" ], "offsets": [ [ 1109, 1123 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d194.s4.e0" } ] }, { "id": "9490", "type": "Genes/Proteins", "text": [ "adenosine kinase" ], "offsets": [ [ 1127, 1143 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d194.s4.e1" } ] }, { "id": "9491", "type": "Genes/Proteins", "text": [ "ADK" ], "offsets": [ [ 1145, 1148 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d194.s4.e2" } ] }, { "id": "9492", "type": "Species", "text": [ "human" ], "offsets": [ [ 1191, 1196 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d194.s4.e3" } ] }, { "id": "9493", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1288, 1296 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d194.s4.e4" } ] }, { "id": "9494", "type": "Species", "text": [ "patient" ], "offsets": [ [ 1310, 1317 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d194.s5.e0" } ] }, { "id": "9495", "type": "Diseases", "text": [ "seizure" ], "offsets": [ [ 1585, 1592 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d194.s7.e0" } ] }, { "id": "9496", "type": "Diseases", "text": [ "epilepsy" ], "offsets": [ [ 1625, 1633 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d194.s7.e1" } ] }, { "id": "9497", "type": "Relation_Trigger", "text": [ "inhibitory" ], "offsets": [ [ 1509, 1519 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d194.s7.e2" } ] }, { "id": "9498", "type": "Relation_Trigger", "text": [ "suppression" ], "offsets": [ [ 1593, 1604 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d194.s7.e3" } ] }, { "id": "9499", "type": "Diseases", "text": [ "seizure" ], "offsets": [ [ 1758, 1765 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d194.s8.e0" } ] }, { "id": "9500", "type": "Relation_Trigger", "text": [ "downregulation" ], "offsets": [ [ 1660, 1674 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d194.s8.e1" } ] }, { "id": "9501", "type": "Genes/Proteins", "text": [ "adenosine kinase" ], "offsets": [ [ 1678, 1694 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d194.s8.e2" } ] }, { "id": "9502", "type": "Species", "text": [ "human" ], "offsets": [ [ 1698, 1703 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d194.s8.e3" } ] } ]

[]

[]

[ { "id": "9503", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d194.s1.e0", "arg2_id": "miRNA-corp.d194.s1.e2", "normalized": [] }, { "id": "9504", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d194.s1.e0", "arg2_id": "miRNA-corp.d194.s1.e3", "normalized": [] }, { "id": "9505", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d194.s1.e0", "arg2_id": "miRNA-corp.d194.s1.e1", "normalized": [] }, { "id": "9506", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d194.s3.e0", "arg2_id": "miRNA-corp.d194.s3.e1", "normalized": [] } ]

[ { "id": "9508", "type": "title", "text": [ "The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo. " ], "offsets": [ [ 0, 111 ] ] }, { "id": "9509", "type": "abstract", "text": [ "Activated oncogenic signaling is central to the development of nearly all forms of cancer, including the most common class of primary brain tumor, glioma. " ], "offsets": [ [ 112, 267 ] ] }, { "id": "9510", "type": "abstract", "text": [ "Recent studies have also demonstrated that microRNAs (miRNAs) may be responsible for the modulation of cancer-implicated genes in tumors. " ], "offsets": [ [ 268, 406 ] ] }, { "id": "9511", "type": "abstract", "text": [ "Here we report the identification miR-26a as a direct regulator of PTEN expression. " ], "offsets": [ [ 407, 491 ] ] }, { "id": "9512", "type": "abstract", "text": [ "We also show that miR-26a is frequently amplified at the DNA level in human glioma, most often in association with monoallelic PTEN loss. " ], "offsets": [ [ 492, 630 ] ] }, { "id": "9513", "type": "abstract", "text": [ "Finally, we demonstrate that miR-26a-mediated PTEN repression in a murine glioma model both enhances de novo tumor formation and precludes loss of heterozygosity and the PTEN locus. " ], "offsets": [ [ 631, 813 ] ] }, { "id": "9514", "type": "abstract", "text": [ "Our results document a new epigenetic mechanism for PTEN regulation in glioma and further highlight dysregulation of Akt signaling as crucial to the development of these tumors. " ], "offsets": [ [ 814, 994 ] ] } ]

[ { "id": "9515", "type": "Diseases", "text": [ "glioma" ], "offsets": [ [ 64, 70 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d195.s0.e0" } ] }, { "id": "9516", "type": "Specific_miRNAs", "text": [ "miR-26a" ], "offsets": [ [ 29, 36 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d195.s0.e1" } ] }, { "id": "9517", "type": "Genes/Proteins", "text": [ "PTEN" ], "offsets": [ [ 4, 8 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d195.s0.e2" } ] }, { "id": "9518", "type": "Non-Specific_miRNAs", "text": [ "microRNA" ], "offsets": [ [ 20, 28 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d195.s0.e3" } ] }, { "id": "9519", "type": "Relation_Trigger", "text": [ "amplified" ], "offsets": [ [ 40, 49 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d195.s0.e4" } ] }, { "id": "9520", "type": "Diseases", "text": [ "glioma" ], "offsets": [ [ 259, 265 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d195.s1.e0" } ] }, { "id": "9521", "type": "Diseases", "text": [ "brain tumor" ], "offsets": [ [ 246, 257 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d195.s1.e1" } ] }, { "id": "9522", "type": "Relation_Trigger", "text": [ "Activated" ], "offsets": [ [ 112, 121 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d195.s1.e2" } ] }, { "id": "9523", "type": "Diseases", "text": [ "cancer" ], "offsets": [ [ 195, 201 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d195.s1.e3" } ] }, { "id": "9524", "type": "Non-Specific_miRNAs", "text": [ "microRNAs" ], "offsets": [ [ 311, 320 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d195.s3.e0" } ] }, { "id": "9525", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 322, 328 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d195.s3.e1" } ] }, { "id": "9526", "type": "Relation_Trigger", "text": [ "modulation" ], "offsets": [ [ 357, 367 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d195.s3.e2" } ] }, { "id": "9527", "type": "Diseases", "text": [ "tumors" ], "offsets": [ [ 398, 404 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d195.s3.e3" } ] }, { "id": "9528", "type": "Diseases", "text": [ "cancer" ], "offsets": [ [ 371, 377 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d195.s3.e4" } ] }, { "id": "9529", "type": "Genes/Proteins", "text": [ "PTEN" ], "offsets": [ [ 474, 478 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d195.s4.e0" } ] }, { "id": "9530", "type": "Specific_miRNAs", "text": [ "miR-26a" ], "offsets": [ [ 441, 448 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d195.s4.e1" } ] }, { "id": "9531", "type": "Relation_Trigger", "text": [ "regulator of PTEN expression" ], "offsets": [ [ 461, 489 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d195.s4.e2" } ] }, { "id": "9532", "type": "Genes/Proteins", "text": [ "PTEN" ], "offsets": [ [ 619, 623 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d195.s5.e0" } ] }, { "id": "9533", "type": "Specific_miRNAs", "text": [ "miR-26a" ], "offsets": [ [ 510, 517 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d195.s5.e1" } ] }, { "id": "9534", "type": "Diseases", "text": [ "glioma" ], "offsets": [ [ 568, 574 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d195.s5.e2" } ] }, { "id": "9535", "type": "Relation_Trigger", "text": [ "amplified" ], "offsets": [ [ 532, 541 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d195.s5.e3" } ] }, { "id": "9536", "type": "Relation_Trigger", "text": [ "association with monoallelic PTEN loss" ], "offsets": [ [ 590, 628 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d195.s5.e4" } ] }, { "id": "9537", "type": "Species", "text": [ "human" ], "offsets": [ [ 562, 567 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d195.s5.e5" } ] }, { "id": "9538", "type": "Genes/Proteins", "text": [ "PTEN" ], "offsets": [ [ 677, 681 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d195.s6.e0" } ] }, { "id": "9539", "type": "Genes/Proteins", "text": [ "PTEN" ], "offsets": [ [ 801, 805 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d195.s6.e1" } ] }, { "id": "9540", "type": "Diseases", "text": [ "glioma" ], "offsets": [ [ 705, 711 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d195.s6.e2" } ] }, { "id": "9541", "type": "Specific_miRNAs", "text": [ "miR-26a" ], "offsets": [ [ 660, 667 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d195.s6.e3" } ] }, { "id": "9542", "type": "Relation_Trigger", "text": [ "repression" ], "offsets": [ [ 682, 692 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d195.s6.e4" } ] }, { "id": "9543", "type": "Diseases", "text": [ "tumor" ], "offsets": [ [ 740, 745 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d195.s6.e5" } ] }, { "id": "9544", "type": "Species", "text": [ "murine" ], "offsets": [ [ 698, 704 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d195.s6.e6" } ] }, { "id": "9545", "type": "Genes/Proteins", "text": [ "PTEN" ], "offsets": [ [ 866, 870 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d195.s7.e0" } ] }, { "id": "9546", "type": "Diseases", "text": [ "glioma" ], "offsets": [ [ 885, 891 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d195.s7.e1" } ] }, { "id": "9547", "type": "Relation_Trigger", "text": [ "regulation" ], "offsets": [ [ 871, 881 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d195.s7.e2" } ] }, { "id": "9548", "type": "Relation_Trigger", "text": [ "dysregulation" ], "offsets": [ [ 914, 927 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d195.s7.e3" } ] }, { "id": "9549", "type": "Diseases", "text": [ "tumors" ], "offsets": [ [ 984, 990 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d195.s7.e4" } ] } ]

[]

[]

[ { "id": "9550", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d195.s0.e1", "arg2_id": "miRNA-corp.d195.s0.e0", "normalized": [] }, { "id": "9551", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d195.s0.e1", "arg2_id": "miRNA-corp.d195.s0.e2", "normalized": [] }, { "id": "9552", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d195.s0.e3", "arg2_id": "miRNA-corp.d195.s0.e0", "normalized": [] }, { "id": "9553", "type": "Non-Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d195.s0.e3", "arg2_id": "miRNA-corp.d195.s0.e2", "normalized": [] }, { "id": "9554", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d195.s3.e0", "arg2_id": "miRNA-corp.d195.s3.e3", "normalized": [] }, { "id": "9555", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d195.s3.e0", "arg2_id": "miRNA-corp.d195.s3.e4", "normalized": [] }, { "id": "9556", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d195.s3.e1", "arg2_id": "miRNA-corp.d195.s3.e3", "normalized": [] }, { "id": "9557", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d195.s3.e1", "arg2_id": "miRNA-corp.d195.s3.e4", "normalized": [] }, { "id": "9558", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d195.s4.e1", "arg2_id": "miRNA-corp.d195.s4.e0", "normalized": [] }, { "id": "9559", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d195.s5.e1", "arg2_id": "miRNA-corp.d195.s5.e2", "normalized": [] }, { "id": "9560", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d195.s5.e1", "arg2_id": "miRNA-corp.d195.s5.e0", "normalized": [] }, { "id": "9561", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d195.s6.e3", "arg2_id": "miRNA-corp.d195.s6.e5", "normalized": [] }, { "id": "9562", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d195.s6.e3", "arg2_id": "miRNA-corp.d195.s6.e0", "normalized": [] }, { "id": "9563", "type": "Specific_miRNAs-Genes/Proteins", "arg1_id": "miRNA-corp.d195.s6.e3", "arg2_id": "miRNA-corp.d195.s6.e1", "normalized": [] }, { "id": "9564", "type": "Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d195.s6.e3", "arg2_id": "miRNA-corp.d195.s6.e2", "normalized": [] } ]

[ { "id": "9566", "type": "title", "text": [ "The research was divided into two studies: the first one the test was adapted, and in order to check its capacity to investigate the deficits of SOM, it has applied in groups of 10 (ten) subjects, one group with patients that have Alzheimer disease and the other one with healthy elderly (p<0.001). " ], "offsets": [ [ 0, 299 ] ] }, { "id": "9567", "type": "abstract", "text": [ "This study had the purpose to adapt a test based in these experiments in order to check the performance of SOM and the participation of hippocampus into SOM in patients with mesial temporal sclerosis (MTS). " ], "offsets": [ [ 300, 507 ] ] }, { "id": "9568", "type": "abstract", "text": [ "Experimental studies have identified pyramidal cells in hippocampus in rats with participation in the spatial orientation memory (SOM), which are named location cells. " ], "offsets": [ [ 508, 676 ] ] }, { "id": "9569", "type": "abstract", "text": [ "[Spatial orientation memory: evaluation in patents with Alzheimer disease and temporal lobe epilepsy]. " ], "offsets": [ [ 677, 781 ] ] }, { "id": "9570", "type": "abstract", "text": [ "The second study has evaluated the participation of hippocampus into SOM in 43 patients (23 with mesial temporal sclerosis (MTS) and 20 submitted to selective amygdala hippocampectomy (SAH)) and 23 healthy volunteers with p<0,05 between MTS and SAH and between controlled and SAH. " ], "offsets": [ [ 782, 1063 ] ] }, { "id": "9571", "type": "abstract", "text": [ "It was shown that the test of SOM is suitable to evaluate deficits, but it seems the SOM is not a specific function of human hippocampus. " ], "offsets": [ [ 1064, 1204 ] ] } ]

[ { "id": "9572", "type": "Diseases", "text": [ "Alzheimer disease" ], "offsets": [ [ 231, 248 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d196.s0.e0" } ] }, { "id": "9573", "type": "Species", "text": [ "patients" ], "offsets": [ [ 212, 220 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d196.s0.e1" } ] }, { "id": "9574", "type": "Diseases", "text": [ "mesial temporal sclerosis" ], "offsets": [ [ 474, 499 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d196.s1.e0" } ] }, { "id": "9575", "type": "Diseases", "text": [ "MTS" ], "offsets": [ [ 501, 504 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d196.s1.e1" } ] }, { "id": "9576", "type": "Species", "text": [ "patients" ], "offsets": [ [ 460, 468 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d196.s1.e2" } ] }, { "id": "9577", "type": "Species", "text": [ "rats" ], "offsets": [ [ 579, 583 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d196.s2.e0" } ] }, { "id": "9578", "type": "Diseases", "text": [ "Alzheimer disease" ], "offsets": [ [ 733, 750 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d196.s3.e0" } ] }, { "id": "9579", "type": "Diseases", "text": [ "temporal lobe epilepsy" ], "offsets": [ [ 755, 777 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d196.s3.e1" } ] }, { "id": "9580", "type": "Diseases", "text": [ "mesial temporal sclerosis" ], "offsets": [ [ 879, 904 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d196.s4.e0" } ] }, { "id": "9581", "type": "Diseases", "text": [ "MTS" ], "offsets": [ [ 906, 909 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d196.s4.e1" } ] }, { "id": "9582", "type": "Diseases", "text": [ "MTS" ], "offsets": [ [ 1019, 1022 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d196.s4.e2" } ] }, { "id": "9583", "type": "Species", "text": [ "patients" ], "offsets": [ [ 861, 869 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d196.s4.e3" } ] }, { "id": "9584", "type": "Species", "text": [ "human" ], "offsets": [ [ 1183, 1188 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d196.s5.e0" } ] } ]

[]

[]

[]

[ { "id": "9586", "type": "title", "text": [ "Potential role of miRNAs and their inhibitors in glioma treatment. " ], "offsets": [ [ 0, 68 ] ] }, { "id": "9587", "type": "abstract", "text": [ "Recent years have seen an intense period of research on the functions of miRNAs, recently discovered key regulators of gene expression that act through suppression of translation of target mRNAs. " ], "offsets": [ [ 69, 265 ] ] }, { "id": "9588", "type": "abstract", "text": [ "Several hundred miRNAs have been identified in humans, and these show characteristic expression patterns, depending on tissue type, cell type or environmental stimuli. " ], "offsets": [ [ 266, 434 ] ] }, { "id": "9589", "type": "abstract", "text": [ "Like other types of cancer, the brain tumor glioblastoma shows a distinct miRNA expression signature, and a number of recent studies have linked these miRNA alterations to key hallmarks of glioblastoma including proliferation, survival, invasion, angiogenesis and stem cell-like behavior. " ], "offsets": [ [ 435, 724 ] ] }, { "id": "9590", "type": "abstract", "text": [ "These studies have opened the door to the possibility of utilizing miRNAs or miRNA antagonists as therapeutic agents for the treatment of brain tumors. " ], "offsets": [ [ 725, 879 ] ] } ]

[ { "id": "9591", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 18, 24 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d197.s0.e0" } ] }, { "id": "9592", "type": "Diseases", "text": [ "glioma" ], "offsets": [ [ 49, 55 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d197.s0.e1" } ] }, { "id": "9593", "type": "Relation_Trigger", "text": [ "inhibitors" ], "offsets": [ [ 35, 45 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d197.s0.e2" } ] }, { "id": "9594", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 142, 148 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d197.s1.e0" } ] }, { "id": "9595", "type": "Relation_Trigger", "text": [ "regulators" ], "offsets": [ [ 174, 184 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d197.s1.e1" } ] }, { "id": "9596", "type": "Relation_Trigger", "text": [ "suppression of translation" ], "offsets": [ [ 221, 247 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d197.s1.e2" } ] }, { "id": "9597", "type": "Relation_Trigger", "text": [ "target" ], "offsets": [ [ 251, 257 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d197.s1.e3" } ] }, { "id": "9598", "type": "Relation_Trigger", "text": [ "expression that act through suppression" ], "offsets": [ [ 193, 232 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d197.s1.e4" } ] }, { "id": "9599", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 282, 288 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d197.s2.e0" } ] }, { "id": "9600", "type": "Species", "text": [ "humans" ], "offsets": [ [ 313, 319 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d197.s2.e1" } ] }, { "id": "9601", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 509, 514 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d197.s3.e0" } ] }, { "id": "9602", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 586, 591 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d197.s3.e1" } ] }, { "id": "9603", "type": "Diseases", "text": [ "brain tumor" ], "offsets": [ [ 467, 478 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d197.s3.e2" } ] }, { "id": "9604", "type": "Diseases", "text": [ "glioblastoma" ], "offsets": [ [ 479, 491 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d197.s3.e3" } ] }, { "id": "9605", "type": "Diseases", "text": [ "glioblastoma" ], "offsets": [ [ 624, 636 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d197.s3.e4" } ] }, { "id": "9606", "type": "Diseases", "text": [ "cancer" ], "offsets": [ [ 455, 461 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d197.s3.e5" } ] }, { "id": "9607", "type": "Non-Specific_miRNAs", "text": [ "miRNAs" ], "offsets": [ [ 792, 798 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d197.s4.e0" } ] }, { "id": "9608", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 802, 807 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d197.s4.e1" } ] }, { "id": "9609", "type": "Diseases", "text": [ "brain tumors" ], "offsets": [ [ 863, 875 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d197.s4.e2" } ] } ]

[]

[]

[ { "id": "9610", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d197.s0.e0", "arg2_id": "miRNA-corp.d197.s0.e1", "normalized": [] }, { "id": "9611", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d197.s3.e0", "arg2_id": "miRNA-corp.d197.s3.e4", "normalized": [] }, { "id": "9612", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d197.s3.e0", "arg2_id": "miRNA-corp.d197.s3.e5", "normalized": [] }, { "id": "9613", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d197.s3.e0", "arg2_id": "miRNA-corp.d197.s3.e2", "normalized": [] }, { "id": "9614", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d197.s3.e0", "arg2_id": "miRNA-corp.d197.s3.e3", "normalized": [] }, { "id": "9615", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d197.s3.e1", "arg2_id": "miRNA-corp.d197.s3.e4", "normalized": [] }, { "id": "9616", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d197.s3.e1", "arg2_id": "miRNA-corp.d197.s3.e5", "normalized": [] }, { "id": "9617", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d197.s3.e1", "arg2_id": "miRNA-corp.d197.s3.e2", "normalized": [] }, { "id": "9618", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d197.s3.e1", "arg2_id": "miRNA-corp.d197.s3.e3", "normalized": [] }, { "id": "9619", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d197.s4.e0", "arg2_id": "miRNA-corp.d197.s4.e2", "normalized": [] }, { "id": "9620", "type": "Non-Specific_miRNAs-Diseases", "arg1_id": "miRNA-corp.d197.s4.e1", "arg2_id": "miRNA-corp.d197.s4.e2", "normalized": [] } ]

[ { "id": "9622", "type": "abstract", "text": [ "RESULTS: Both Pol II and Pol III promoters have been successfully combined with a second expression cassette containing a codon-optimized tetracycline repressor and selectable marker. " ], "offsets": [ [ 0, 184 ] ] }, { "id": "9623", "type": "abstract", "text": [ "We have therefore developed pHUSH, an inducible expression system that allows regulated expression of shRNA, miRNA or cDNA cassettes on a single viral vector. " ], "offsets": [ [ 185, 344 ] ] }, { "id": "9624", "type": "abstract", "text": [ "However, most systems require multiple plasmids that must be independently engineered into the target system, resulting in experimental delay and an increased potential for selection of a cell subpopulation that differs significantly from the parental line. " ], "offsets": [ [ 345, 603 ] ] }, { "id": "9625", "type": "abstract", "text": [ "CONCLUSION: We have successfully developed and employed a single vector system that enables Doxycycline regulated RNAi or transgene expression in a variety of in vitro and in vivo model systems. " ], "offsets": [ [ 604, 799 ] ] }, { "id": "9626", "type": "abstract", "text": [ "We provide examples of how pHUSH has been successfully employed to study the function of target genes in a number of cell types within in vitro and in vivo assays, including conditional gene knockdown in a murine model of brain cancer. " ], "offsets": [ [ 800, 1036 ] ] } ]

[ { "id": "9627", "type": "Relation_Trigger", "text": [ "repressor" ], "offsets": [ [ 151, 160 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d198.s1.e0" } ] }, { "id": "9628", "type": "Non-Specific_miRNAs", "text": [ "miRNA" ], "offsets": [ [ 294, 299 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d198.s2.e0" } ] }, { "id": "9629", "type": "Relation_Trigger", "text": [ "regulated expression" ], "offsets": [ [ 263, 283 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d198.s2.e1" } ] }, { "id": "9630", "type": "Relation_Trigger", "text": [ "target" ], "offsets": [ [ 440, 446 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d198.s3.e0" } ] }, { "id": "9631", "type": "Relation_Trigger", "text": [ "regulated" ], "offsets": [ [ 708, 717 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d198.s6.e0" } ] }, { "id": "9632", "type": "Relation_Trigger", "text": [ "target" ], "offsets": [ [ 889, 895 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d198.s7.e0" } ] }, { "id": "9633", "type": "Diseases", "text": [ "brain cancer" ], "offsets": [ [ 1022, 1034 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d198.s7.e1" } ] }, { "id": "9634", "type": "Species", "text": [ "murine" ], "offsets": [ [ 1006, 1012 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d198.s7.e2" } ] } ]

[]

[]

[]

[ { "id": "9636", "type": "title", "text": [ "SIGNIFICANCE: Our results show for the first time that the R337H TP53 mutation is responsible for 63% of the CPC cases in children, suggesting a higher incidence of CPC in southern Brazil. " ], "offsets": [ [ 0, 191 ] ] }, { "id": "9637", "type": "abstract", "text": [ "Family history of cancer (with 2 or more cancer cases) was exclusively identified on the parental side segregating the R337H mutation, and 50% (7/14) of them were compatible with Li-Fraumeni-like syndrome. " ], "offsets": [ [ 192, 398 ] ] }, { "id": "9638", "type": "abstract", "text": [ "Cure (>5 years survival free of disease) was observed in 18.1% of the CPC cases with the R337H mutation (2/11), 71.4% of the Pp (5/7), and 25% of CPC cases negative for the R337H mutation (2/8). " ], "offsets": [ [ 399, 594 ] ] }, { "id": "9639", "type": "abstract", "text": [ "We found 63.3% (14/22) of the CPC patients positive for the germline R337H mutation; CPC samples were either heterozygous (n = 7), lost only the wild-type (n = 4), or only the R337H copy (n = 2). " ], "offsets": [ [ 595, 791 ] ] }, { "id": "9640", "type": "abstract", "text": [ "The patients, all parents, and some relatives submitted samples for blood DNA analysis. " ], "offsets": [ [ 792, 880 ] ] }, { "id": "9641", "type": "abstract", "text": [ "In addition, we have also examined the presence of the mutation in DNA from paraffin-embedded tumor samples to evaluate loss of heterozygosity. " ], "offsets": [ [ 881, 1025 ] ] }, { "id": "9642", "type": "abstract", "text": [ "BACKGROUND: Choroid plexus carcinomas (CPC) are rare tumors predominantly found in children. " ], "offsets": [ [ 1026, 1119 ] ] }, { "id": "9643", "type": "abstract", "text": [ "Increased incidence of choroid plexus carcinoma due to the germline TP53 R337H mutation in southern Brazil. " ], "offsets": [ [ 1120, 1229 ] ] }, { "id": "9644", "type": "abstract", "text": [ "Blood and/or tumor DNA was extracted and analyzed using PCR-RFLP and results were confirmed by sequencing 240 bp of the TP53 exon 10. " ], "offsets": [ [ 1230, 1364 ] ] }, { "id": "9645", "type": "abstract", "text": [ "Surgical resection was possible in 28 children. " ], "offsets": [ [ 1365, 1413 ] ] }, { "id": "9646", "type": "abstract", "text": [ "METHODOLOGY/PRINCIPAL FINDINGS: The present series included 29 patients that were admitted to the same institution from 1992 to 2010, including 22 children with CPC (0.08-13.6 years of age at diagnosis) and 7 children with papilloma of the choroid plexus (Pp; 0.5-9.8 years of age). " ], "offsets": [ [ 1414, 1697 ] ] }, { "id": "9647", "type": "abstract", "text": [ "Given the high frequency of the germline R337H mutation in the TP53 gene in southern Brazil, we have evaluated the frequency of the R337H mutation in families with CPC in children. " ], "offsets": [ [ 1698, 1879 ] ] } ]

[ { "id": "9648", "type": "Genes/Proteins", "text": [ "TP53" ], "offsets": [ [ 65, 69 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d199.s0.e0" } ] }, { "id": "9649", "type": "Diseases", "text": [ "CPC" ], "offsets": [ [ 109, 112 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d199.s0.e1" } ] }, { "id": "9650", "type": "Diseases", "text": [ "CPC" ], "offsets": [ [ 165, 168 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d199.s0.e2" } ] }, { "id": "9651", "type": "Species", "text": [ "children" ], "offsets": [ [ 122, 130 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d199.s0.e3" } ] }, { "id": "9652", "type": "Diseases", "text": [ "cancer" ], "offsets": [ [ 210, 216 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d199.s1.e0" } ] }, { "id": "9653", "type": "Diseases", "text": [ "Li-Fraumeni-like syndrome" ], "offsets": [ [ 371, 396 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d199.s1.e1" } ] }, { "id": "9654", "type": "Diseases", "text": [ "cancer" ], "offsets": [ [ 233, 239 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d199.s1.e2" } ] }, { "id": "9655", "type": "Diseases", "text": [ "CPC" ], "offsets": [ [ 469, 472 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d199.s2.e0" } ] }, { "id": "9656", "type": "Diseases", "text": [ "CPC" ], "offsets": [ [ 545, 548 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d199.s2.e1" } ] }, { "id": "9657", "type": "Diseases", "text": [ "CPC" ], "offsets": [ [ 680, 683 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d199.s4.e0" } ] }, { "id": "9658", "type": "Species", "text": [ "patients" ], "offsets": [ [ 629, 637 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d199.s4.e1" } ] }, { "id": "9659", "type": "Species", "text": [ "patients" ], "offsets": [ [ 796, 804 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d199.s6.e0" } ] }, { "id": "9660", "type": "Diseases", "text": [ "tumor" ], "offsets": [ [ 975, 980 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d199.s7.e0" } ] }, { "id": "9661", "type": "Diseases", "text": [ "Choroid plexus carcinomas" ], "offsets": [ [ 1038, 1063 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d199.s8.e0" } ] }, { "id": "9662", "type": "Diseases", "text": [ "CPC" ], "offsets": [ [ 1065, 1068 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d199.s8.e1" } ] }, { "id": "9663", "type": "Diseases", "text": [ "tumors" ], "offsets": [ [ 1079, 1085 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d199.s8.e2" } ] }, { "id": "9664", "type": "Species", "text": [ "children" ], "offsets": [ [ 1109, 1117 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d199.s8.e3" } ] }, { "id": "9665", "type": "Diseases", "text": [ "carcinoma" ], "offsets": [ [ 1158, 1167 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d199.s9.e0" } ] }, { "id": "9666", "type": "Genes/Proteins", "text": [ "TP53" ], "offsets": [ [ 1188, 1192 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d199.s9.e1" } ] }, { "id": "9667", "type": "Diseases", "text": [ "tumor" ], "offsets": [ [ 1243, 1248 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d199.s10.e0" } ] }, { "id": "9668", "type": "Genes/Proteins", "text": [ "TP53" ], "offsets": [ [ 1350, 1354 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d199.s10.e1" } ] }, { "id": "9669", "type": "Species", "text": [ "children" ], "offsets": [ [ 1403, 1411 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d199.s11.e0" } ] }, { "id": "9670", "type": "Diseases", "text": [ "papilloma" ], "offsets": [ [ 1637, 1646 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d199.s12.e0" } ] }, { "id": "9671", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1477, 1485 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d199.s12.e1" } ] }, { "id": "9672", "type": "Species", "text": [ "children" ], "offsets": [ [ 1561, 1569 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d199.s12.e2" } ] }, { "id": "9673", "type": "Species", "text": [ "children" ], "offsets": [ [ 1623, 1631 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d199.s12.e3" } ] }, { "id": "9674", "type": "Genes/Proteins", "text": [ "TP53" ], "offsets": [ [ 1761, 1765 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d199.s13.e0" } ] }, { "id": "9675", "type": "Diseases", "text": [ "CPC" ], "offsets": [ [ 1862, 1865 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d199.s13.e1" } ] }, { "id": "9676", "type": "Species", "text": [ "children" ], "offsets": [ [ 1869, 1877 ] ], "normalized": [ { "db_name": "miRNA-corpus", "db_id": "miRNA-corp.d199.s13.e2" } ] } ]

[]

[]

[]